Channel:  Harvard Program in Therapeutic Sciences

119 Articles

A tool for browsing the Cancer Dependency Map reveals functional connections between genes and helps predict the efficacy and selectivity of candidate cancer drugs
Shimada, K., Muchlich, J. L., Mitchison, T. J.
10.1101/2019.12.13.874776 — Posted: 2019-12-18
Robustness and parameter geography in post-translational modification systems
Nam, K.-M., Gyori, B. M., Amethyst, S. V., Bates, D. J., Gunawardena, J.
10.1101/862003 — Posted: 2019-12-02
Systemic immune response profiling with SYLARAS implicates a role for CD45R/B220+ CD8+ T cells in glioblastoma immunology
Baker, G. J., Muhlich, J. L., Palaniappan, S. K., Moore, J. K., Davis, S. H., Santagata, S., Sorger, P. K.
10.1101/555854 — Posted: 2019-10-22
Sporadic ERK pulses drive non-genetic resistance in drug-adapted BRAFV600E melanoma cells
Gerosa, L., Chidley, C., Froehlich, F., Sanchez, G., Lim, S. K., Muhlich, J., Chen, J.-Y., Baker, G. J., Schapiro, D., Shi, T., Yi, L., Nicora, C. D., Claas, A., Lauffenburger, D. A., Qian, W.-J., Wiley, H. S., Sorger, P. K.
10.1101/762294 — Posted: 2019-09-08
GeneWalk identifies relevant gene functions for a biological context using network representation learning
Ietswaart, R., Gyori, B. M., Bachman, J. A., Sorger, P. K., Churchman, L. S.
10.1101/755579 — Posted: 2019-09-05
Inferring reaction network structure from single-cell, multiplex data, using toric systems theory
Wang, S., Lin, J.-r., Sontag, E. D., Sorger, P. K.
10.1101/731018 — Posted: 2019-08-09
Rapid heuristic inference of antibiotic resistance and susceptibility by genomic neighbor typing
Brinda, K., Callendrello, A., Ma, K. C., MacFadden, D. R., Charalampous, T., Lee, R. S., Cowley, L., Wadsworth, C. B., Grad, Y. H., Kucherov, G., O'Grady, J., Baym, M., Hanage, W. P.
10.1101/403204 — Posted: 2019-08-07
Opposing immune and genetic forces shape oncogenic programs in synovial sarcoma
Jerby, L., Neftel, C., Shore, M. E., McBride, M. J., Haas, B., Izar, B., Weissman, H. R., Volorio, A., Boulay, G., Cironi, L., Richman, A. R., Broye, L. C., Gurski, J. M., Luo, C. C., Mylvaganam, R., Nguyen, L., Mei, S., Melms, J. c., Georgescu, C., Cohen, O., Buendia-Buendia, J. E., Cuoco, M. S., Labes, D., Zollinger, D. R., Beechem, J. M., Nielsen, P., Chebib, I., Cote, G., Choy, E., Letovanec, I., Cherix, S., Wagle, N., Sorger, P. K., Haynes, A. B., Mullen, J. T., Stamenkovic, I., Rivera, M. N., Kadoch, C., Rozenblatt-Rosen, O., Suva, M. L., Riggi, N., Regev, A.
10.1101/724302 — Posted: 2019-08-04
Facetto: Combining Unsupervised and Supervised Learning for Hierarchical Phenotype Analysis in Multi-Channel Image Data
Krueger, R., Beyer, J., Jang, W.-D., Kim, N. W., Sokolov, A., Sorger, P. K., Pfister, H.
10.1101/722918 — Posted: 2019-08-02
Highly multiplexed immunofluorescence images and single-cell data of immune markers in tonsil and lung cancer
Rashid, R., Gaglia, G., Chen, Y.-A., Lin, J.-R., Du, Z., Maliga, Z., Schapiro, D., Yapp, C., Muhlich, J., Sokolov, A., Sorger, P., Santagata, S.
10.1101/704114 — Posted: 2019-07-17

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