Channel:  Harvard Program in Therapeutic Sciences

127 Articles

Spatially organized lymphocytic microenvironments in high grade primary prostate tumors
Amiryousefi, A., Wala, J., Lin, J.-R., Labadie, B. W., Atmakuri, A., Maliga, Z., Toye, E., Chaudagar, K., Torcasso, M. S., Coy, S., Fanelli, G. N., Kobs, B., Socciarelli, F., Gagne, A., Van Allen, E., Patnaik, A., Sorger, P. K.
10.1101/2025.09.21.677465 — Posted: 2025-09-21
SEAL: Spatially-resolved Embedding Analysis with Linked Imaging Data
Warchol, S., Guo, G., Knittel, J., Freeman, D., Bhalla, U., Muhlich, J. L., Sorger, P. K., Pfister, H.
10.1101/2025.07.19.665696 — Posted: 2025-07-28
Antigen reactivity defines tissue-resident memory and exhausted T cells in tumours
Burn, T. N., Schroeder, J., Gandolfo, L. C., Osman, M., Wainwright, E. N., Lam, E. Y. N., McDonald, K. M., Evans, R. B., Lee, S., Rawlinson, D., Dryburgh, L., Zaid, A., Maliga, Z., Schienstock, D., Meiser, P., Lee, H. J., Lai, H., Moreira, M. L., Zareie, P., Lee, H.-Y., Huq, L., Christo, S. N., Seow, J. J. W., Ching, K. A., Guillaume, S. M., Knezevic, K., Park, S. L., Evrard, M., Waithman, J., Gebhardt, T., Mueller, S. N., Riddiough, G. E., Perini, M. V., Tsao, S. C. H., Speed, T. P., Sorger, P., Loi, S., Carbone, F. R., Gras, S., Fisher, T. S., Baaten, B. J., Dawson, M. A., Mackay, L. K.
10.1101/2025.07.23.666465 — Posted: 2025-07-23
Highly Multiplexed 3D Profiling of Cell States and Immune Niches in Human Tumours
Yapp, C., Nirmal, A. J., Zhou, F. Y., Wong, A. Y. H., Tefft, J., Lu, Y. D., Shang, Z., Maliga, Z., Montero Llopis, P., Murphy, G. F., Lian, C., Danuser, G., Santagata, S., Sorger, P. K.
10.1101/2023.11.10.566670 — Posted: 2025-04-11
Universal consensus 3D segmentation of cells from 2D segmented stacks
Zhou, F. Y., Marin, Z., Yapp, C., Zou, Q., Nanes, B. A., Daetwyler, S., Jamieson, A., Islam, M. T., Jenkins, E., Gihana, G. M., Lin, J., Borges, H. M., Chang, B.-J., Weems, A., Morrison, S. J., Sorger, P. K., Fiolka, R. P., Dean, K. M., Danuser, G.
10.1101/2024.05.03.592249 — Posted: 2025-03-20
Dynamic Modeling of Cell Cycle Arrest Through Integrated Single-Cell and Mathematical Modelling Approaches
Cortes-Rios, J., Rodriguez-Fernandez, M., Sorger, P. K., Fröhlich, F.
10.1101/2025.02.20.639240 — Posted: 2025-02-26
Transitions in the proteome and phospho-proteome during early embryonic development in Xenopus
Van Itallie, E., Sonnett, M., Kalocsay, M., Wuhr, M., Peshkin, L., Kirschner, M. W.
10.1101/2021.08.05.455309 — Posted: 2025-02-17
Longitudinal and multimodal auditing of tumor adaptation to CDK4/6 inhibitors in HR+ metastatic breast cancers
Creason, A. L., Egger, J., Watson, C., Sivagnanam, S., Chin, K., MacPherson, K., Lin, J.-R., Chen, Y.-A., Johnson, B. E., Feiler, H. S., Galipeau, D., Navin, N. E., Demir, E., Chang, Y. H., Corless, C. L., Mitri, Z. I., Thomas, G., Sorger, P. K., Adey, A. C., Coussens, L. M., Gray, J. W., Mills, G. B., Goecks, J.
10.1101/2023.09.27.557464 — Posted: 2025-01-06
Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma
Kader, T., Lin, J.-R., Hug, C., Coy, S., Chen, Y.-A., de Bruijn, I., Shih, N., Jung, E., Pelletier, R. J., Leon, M. L., Mingo, G., Omran, D. K., Lee, J. S., Yapp, C., Satravada, B. A., Kundra, R., Xu, Y., Chan, S., Tefft, J., Muhlich, J. L., Kim, S., Gysler, S. M., Agudo, J., Heath, J. R., Schultz, N., Drescher, C., Sorger, P. K., Drapkin, R., Santagata, S.
10.1101/2024.09.25.615007 — Posted: 2024-09-27
Integrating spatial profiles and cancer genomics to identify immune-infiltrated mismatch repair proficient colorectal cancers
Wala, J., de Bruijn, I., Coy, S., Gagne, A., Chan, S., Chen, Y.-A., Hoffer, J., Muhlich, J., Schultz, N., Santagata, S., Sorger, P.
10.1101/2024.09.24.614701 — Posted: 2024-09-26

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