Channel:  Harvard Program in Therapeutic Sciences

127 Articles

A Web-based Software Resource for Interactive Analysis of Multiplex Tissue Imaging Datasets
Creason, A. L., Watson, C., Gu, Q., Persson, D., Sargent, L. L., Chen, Y.-A., Lin, J.-R., Sivagnanam, S., Wünnemann, F., Nirmal, A. J., Chin, K., Feiler, H. S., Holly, H., Coussens, L. M., Schapiro, D., Grüning, B. A., Sorger, P. K., Sokolov, A., Goecks, J.
10.1101/2022.08.18.504436 — Posted: 2026-06-07
Volumetric Cyclic Immunofluorescence for 3D Spatial Profiling of Immune Structures in Human FFPE Tissue
Wong, A. Y. H., Lu, Y. D., Zhao, Z., Zhou, F., Park, H., Maliga, z., Anang, Y., Coy, S., Danuser, G., Santagata, S., Yapp, C., Sorger, P. K.
10.64898/2026.05.17.725158 — Posted: 2026-05-27
Multiomic analysis identifies suppressive myeloid cell populations in human TB granulomas.
Jain, N., Ogbonna, E. C., Maliga, Z., Jacobson, C. A., Zhang, L., Shih, A. R., Rosenberg, J. M., Kalam, H., Gagne, A., Solomon, I. H., Santagata, S., Sorger, P. K., Aldridge, B. B., Martinot, A. J.
10.1101/2025.03.10.642376 — Posted: 2026-04-18
Spatial determinants of tumor cell dedifferentiation and plasticity in primary cutaneous melanoma
Vallius, T., Shi, Y., Novikov, E., Pant, S. M., Pelletier, R., Chen, Y.-A., Tefft, J. B., Nirmal, A. J., Maliga, Z., Wan, G., DeSimone, M., Murphy, G., Santagata, S., Semenov, Y., Liu, D., Lian, C. G., Sorger, P. K.
10.1101/2025.06.21.660851 — Posted: 2026-01-20
Ribosome-associated quality control of aberrant protein production during amino acid limitation
Darnell, A. M., Chidley, C., Paradise, V., Cui, D. S., Davidsen, K., Lincoln, S. C., Abbott, K. L., Elbashir, R., Vander Heiden, C. P., Sorger, P. K., Sullivan, L. B., Davis, J. H., Vander Heiden, M. G.
10.64898/2026.01.14.699605 — Posted: 2026-01-15
In vivo evidence for bleb-induced survival signaling in metastatic melanoma
Weems, A. D., Islam, M. T., Borges, H., Yapp, C., Perez-Castro, L., Nogueira, P., Lin, J., Maliga, Z., Lewis, A. J., Kutter, C., Mannino, M., Vallius, T., Santagata, S., Sorger, P. K., Conacci-Sorrell, M., Dean, K. M., Danuser, G. M.
10.64898/2026.01.05.697601 — Posted: 2026-01-05
Mechanisms of tumor persistence in metastatic melanoma following successful immunotherapy
Shi, Y., Maliga, Z., Vallius, T., Pant, S. M., Pelletier, R., Kobs, B., Solanky, P., He, Y., Van Allen, E., Santagata, S., Ott, P., Lian, C. G., Buchbinder, E., Liu, D., Sorger, P. K.
10.64898/2025.12.11.692633 — Posted: 2025-12-15
Morphology-Aware Profiling of Highly Multiplexed Tissue Images using Variational Autoencoders
Baker, G. J., Novikov, E., Coy, S., Chen, Y.-A., Hug, C. B., Ahmed, Z., Ordonez, S. A. C., Huang, S., Yapp, C., Joshi, G. N., Yanagawa, F., Sokolov, A., Pfister, H., Santagata, S., Sorger, P. K.
10.1101/2025.06.23.661064 — Posted: 2025-12-08
Integrative single-cell and spatial mapping of oxidative stress response uncovers GCLC+ mesenchymal tumor cell state linked with favorable outcomes in triple negative breast cancer
Girnius, N., Vallius, T., Chen, W., Launonen, I.-M., Palomino-Echeverria, S., Lin, J.-R., Mills, C. E., Kauppila, S., Kronqvist, P., Ellonen, A., Perala, M., Withnell, E., Chen, Y.-A., Secrier, M., Santagata, S., Sorger, P. K., Farkkila, A.
10.1101/2025.11.06.686771 — Posted: 2025-11-07
Multiomic profiling of a unique in-transit melanoma cohort identifies melanoma differentiation as predictor of tumor progression and therapy response
Tarantino, G., Zaremba, A., Vallius, T., Woodnorth, M., Hua, Y., Pelletier, R., Lopez Leon, M., Shi, Y., Maliga, Z., Makhzami, S., Aprati, T. J., Karlas, B., Glutsch, V., Schilling, B., Hassel, J., Berking, C., Utikal, J., Meier, F., Meiss, F., Heinzerling, L., Kahler, K., Chen, J., Zimmer, L., Sucker, A., Livingstone, E., Hadaschik, E., Lian, C., Murphy, G., Semenov, Y. R., Boland, G. M., Sorger, P. K., Rambow, F., Liu, D., Schadendorf, D.
10.1101/2025.10.01.679282 — Posted: 2025-10-02

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