Channel:  Harvard Program in Therapeutic Sciences

126 Articles

Spatial determinants of tumor cell dedifferentiation and plasticity in primary cutaneous melanoma
Vallius, T., Shi, Y., Novikov, E., Pant, S. M., Pelletier, R., Chen, Y.-A., Tefft, J. B., Nirmal, A. J., Maliga, Z., Wan, G., DeSimone, M., Murphy, G., Santagata, S., Semenov, Y., Liu, D., Lian, C. G., Sorger, P. K.
10.1101/2025.06.21.660851 — Posted: 2026-01-20
Ribosome-associated quality control of aberrant protein production during amino acid limitation
Darnell, A. M., Chidley, C., Paradise, V., Cui, D. S., Davidsen, K., Lincoln, S. C., Abbott, K. L., Elbashir, R., Vander Heiden, C. P., Sorger, P. K., Sullivan, L. B., Davis, J. H., Vander Heiden, M. G.
10.64898/2026.01.14.699605 — Posted: 2026-01-15
In vivo evidence for bleb-induced survival signaling in metastatic melanoma
Weems, A. D., Islam, M. T., Borges, H., Yapp, C., Perez-Castro, L., Nogueira, P., Lin, J., Maliga, Z., Lewis, A. J., Kutter, C., Mannino, M., Vallius, T., Santagata, S., Sorger, P. K., Conacci-Sorrell, M., Dean, K. M., Danuser, G. M.
10.64898/2026.01.05.697601 — Posted: 2026-01-05
Mechanisms of tumor persistence in metastatic melanoma following successful immunotherapy
Shi, Y., Maliga, Z., Vallius, T., Pant, S. M., Pelletier, R., Kobs, B., Solanky, P., He, Y., Van Allen, E., Santagata, S., Ott, P., Lian, C. G., Buchbinder, E., Liu, D., Sorger, P. K.
10.64898/2025.12.11.692633 — Posted: 2025-12-15
Morphology-Aware Profiling of Highly Multiplexed Tissue Images using Variational Autoencoders
Baker, G. J., Novikov, E., Coy, S., Chen, Y.-A., Hug, C. B., Ahmed, Z., Ordonez, S. A. C., Huang, S., Yapp, C., Joshi, G. N., Yanagawa, F., Sokolov, A., Pfister, H., Santagata, S., Sorger, P. K.
10.1101/2025.06.23.661064 — Posted: 2025-12-08
Integrative single-cell and spatial mapping of oxidative stress response uncovers GCLC+ mesenchymal tumor cell state linked with favorable outcomes in triple negative breast cancer
Girnius, N., Vallius, T., Chen, W., Launonen, I.-M., Palomino-Echeverria, S., Lin, J.-R., Mills, C. E., Kauppila, S., Kronqvist, P., Ellonen, A., Perala, M., Withnell, E., Chen, Y.-A., Secrier, M., Santagata, S., Sorger, P. K., Farkkila, A.
10.1101/2025.11.06.686771 — Posted: 2025-11-07
Multiomic profiling of a unique in-transit melanoma cohort identifies melanoma differentiation as predictor of tumor progression and therapy response
Tarantino, G., Zaremba, A., Vallius, T., Woodnorth, M., Hua, Y., Pelletier, R., Lopez Leon, M., Shi, Y., Maliga, Z., Makhzami, S., Aprati, T. J., Karlas, B., Glutsch, V., Schilling, B., Hassel, J., Berking, C., Utikal, J., Meier, F., Meiss, F., Heinzerling, L., Kahler, K., Chen, J., Zimmer, L., Sucker, A., Livingstone, E., Hadaschik, E., Lian, C., Murphy, G., Semenov, Y. R., Boland, G. M., Sorger, P. K., Rambow, F., Liu, D., Schadendorf, D.
10.1101/2025.10.01.679282 — Posted: 2025-10-02
Spatially organized lymphocytic microenvironments in high grade primary prostate tumors
Amiryousefi, A., Wala, J., Lin, J.-R., Labadie, B. W., Atmakuri, A., Maliga, Z., Toye, E., Chaudagar, K., Torcasso, M. S., Coy, S., Fanelli, G. N., Kobs, B., Socciarelli, F., Gagne, A., Van Allen, E., Patnaik, A., Sorger, P. K.
10.1101/2025.09.21.677465 — Posted: 2025-09-21
SEAL: Spatially-resolved Embedding Analysis with Linked Imaging Data
Warchol, S., Guo, G., Knittel, J., Freeman, D., Bhalla, U., Muhlich, J. L., Sorger, P. K., Pfister, H.
10.1101/2025.07.19.665696 — Posted: 2025-07-28
Antigen reactivity defines tissue-resident memory and exhausted T cells in tumours
Burn, T. N., Schroeder, J., Gandolfo, L. C., Osman, M., Wainwright, E. N., Lam, E. Y. N., McDonald, K. M., Evans, R. B., Lee, S., Rawlinson, D., Dryburgh, L., Zaid, A., Maliga, Z., Schienstock, D., Meiser, P., Lee, H. J., Lai, H., Moreira, M. L., Zareie, P., Lee, H.-Y., Huq, L., Christo, S. N., Seow, J. J. W., Ching, K. A., Guillaume, S. M., Knezevic, K., Park, S. L., Evrard, M., Waithman, J., Gebhardt, T., Mueller, S. N., Riddiough, G. E., Perini, M. V., Tsao, S. C. H., Speed, T. P., Sorger, P., Loi, S., Carbone, F. R., Gras, S., Fisher, T. S., Baaten, B. J., Dawson, M. A., Mackay, L. K.
10.1101/2025.07.23.666465 — Posted: 2025-07-23

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