Channel:  Francis Crick Institute

1,302 Articles

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Topology-aware reconstruction of cellular state landscapes from microscopy using self-supervised learning
Messori, E., Taha, D. M., Fournier, L., Foix Romero, A., Uhlmann, V., Frossard, P., Vincent-Cuaz, C., Patani, R., Luisier, R.
10.64898/2026.05.30.728966 — Posted: 2026-06-03
HKDC1 contributes to aberrant lysosome-mitochondria contact in Niemann-Pick disease type C
Pastore, R., Stanley, J., Kiraly, S., Dubois, C., Monfregola, J., de Luca, A., Guerra, G., Skehel, M., Ballabio, A., Platt, F. M., Eden, E. R.
10.64898/2026.06.01.729255 — Posted: 2026-06-02
CDKL5 phosphorylates neuronal ELAVL proteins to promote mRNA binding, protein synthesis and visual cortex development
Mihaylov, S. R., Lopes, A. T., Silvestre, M., Bianchini, G., Flynn, H. R., Huseynova, A., Strohbuecker, S., Griffith, L., Militti, C., Baltussen, L. L., Yuan, X., Morel, G., Claxton, S., Dempster, K., Lee, F. C. Y., Kanca, O., Köhn, M., Skehel, M., Ule, J., Iacaruso, F., Ultanir, S. K.
10.64898/2026.04.07.716766 — Posted: 2026-05-29
GROQ-seq Datasets Across Transcription Factors (LacI, RamR, VanR), T7 RNA Polymerase and TEV Protease
Spinner, A., Sreenivasan, S., McLellan, J. R., Ikonomova, S. P., Cortade, D. L., dOelsnitz, S., Sheldon, K., Vasilyeva, O. B., Alperovich, N. Y., Chadha, A., Nematollahi, L., Dhroso, A., Sisson, Z., Densmore, D., Hudson, C. M., DeBenedictis, E., Kelly, P. J., Reider Apel, A., Ross, D., Baranowski, C.
10.64898/2026.04.15.718744 — Posted: 2026-05-29
Lineage-specific retrotransposon co-option reveals a conserved ASH2L isoform as an epigenetic primer of developmental gene promoters
Elgood Hunt, E., Vivori, C., Mitter, R., Hannah Johnkingsly Jebaraj, J., Agnadottir, V., Delas, J., Serna Morales, E., Frith, T., Skehel, M., Elosegui-Artola, A., Briscoe, J., van Werven, F.
10.64898/2026.02.25.707914 — Posted: 2026-05-27
Endolysosomal damage promotes intraluminal protein condensate formation that limits cytosolic leakage
LI, X., Zhang, Y., ZHAO, K., Chen, G., Cui, D., Nikan, M., Young, S., Bennett, F., Seth, P. P., Ni, T., Gutierrez, M. G., Jiang, H.
10.64898/2026.05.25.726725 — Posted: 2026-05-25
Mitochondrial Optic Atrophy (OPA)1 expression regulates the injury response to neonatal hypoxia-ischaemia.
Curel, C., Jones, A., Crawford, A. H., Goikolea Vives, A., Chabrier, G., Gil, G., Oregioni, A., Southworth, R., Eykyn, T. R., Stolp, H. B., Nobeli, I., Thornton, C.
10.64898/2026.05.21.726935 — Posted: 2026-05-23
Asymmetric Contrastive Objectives for Efficient Phenotypic Screening
Nightingale, L., Tuersley, J., Warchal, S., Cairoli, A., Howes, J., Shand, C., Powell, A., Green, D., Strange, A., Howell, M.
10.1101/2024.04.19.590313 — Posted: 2026-05-22
A long-chain heparan sulfate capture mechanism directs paracrine GDNF-GFRα1 signalling through RET
Zol-Hanlon, M. I., Rix, B., Bodet-Lefevre, S., Zamora Porras, M., Briggs, D. C., Nans, A., Borg, A. C., Maslen, S. L., Di Maio, A., Feizi, T., Liu, Y., Chopra, P., Boons, G.-J. P., Pavljuk, J., Richter, R. P., Schumann, B., McDonald, N. Q.
10.64898/2026.05.20.726209 — Posted: 2026-05-21
Discovery of a sulfotyrosine-motif in the human TrkB extracellular domain required for agonist activation
Briggs, D. C., Duffy, R. T., Ateaque, S., Maslen, S., Naharaj, H., Barde, Y.-A., DiStefano, P. S., Lindsay, R. M., Armstrong, P. C., Peach, C. J., McDonald, N. Q.
10.64898/2026.05.19.725324 — Posted: 2026-05-21

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