Channel:  Aligning Science Across Parkinson's (ASAP)

526 Articles

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LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development
Adami, A., Garza, R., Gerdes, P., Johansson, P. A., Dorazehi, F., Koutounidou, S., Castilla-Vallmanya, L., Atacho, D. A. M., Sharma, Y., Johansson, J. G., Tam, O., Kirkeby, A., Barker, R. A., Gale Hammell, M., Douse, C. H., Jakobsson, J.
10.1101/2025.01.17.633315 — Posted: 2025-01-17
Alpha-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation
Sitron, C. S., Trinkaus, V. A., Galesic, A., Garhammer, M., Yuste Checa, P., Dransfeld, U., Feigenbutz, D., Zhang, J., Dudanova, I., Harper, J. W., Hartl, F. U.
10.1101/2025.01.13.632710 — Posted: 2025-01-15
Experimental and Computational Methods for Allelic Imbalance Analysis from Single-Nucleus RNA-seq Data
Simmons, S. K., Adiconis, X., Haywood, N., Parker, J., Lin, Z., Liao, Z., Tuncali, I., Al'Khafaji, A., Shin, A., Jagadeesh, K., Gosik, K., Gatzen, M., Smith, J. T., El Kodsi, D. N., Kuras, Y., Baecher-Allan, C., Serrano, G. E., Beach, T. G., Garimella, K., Rozenblatt-Rosen, O., Regev, A., Dong, X., Scherzer, C., Levin, J. Z.
10.1101/2024.08.13.607784 — Posted: 2025-01-15
Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease
Chou, C.-C., Vest, R., Prado, M. A., Wilson-Grady, J., Paulo, J. A., Shibuya, Y., Moran-Losada, P., Lee, T.-T., Luo, J., Gygi, S. P., Kelly, J. W., Finley, D., Wernig, M., Wyss-Coray, T., Frydman, J.
10.1101/2023.03.27.534444 — Posted: 2025-01-13
State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson's disease
Zhai, S., Cui, Q., Wokosin, D., Sun, L., Tkatch, T., Crittenden, J. R., Graybiel, A. M., Surmeier, D. J.
10.1101/2025.01.02.631090 — Posted: 2025-01-07
GPNMB is a biomarker for lysosomal dysfunction and is secreted via LRRK2-modulated lysosomal exocytosis
Bogacki, E. C., Longmore, G., Lewis, P. A., Herbst, S.
10.1101/2025.01.01.630988 — Posted: 2025-01-01
Neuronal alpha-Synuclein Disease stage progression over five years
Simuni, T., Gochanour, C., Nair, A. R., Brumm, M. C., Coffey, C., Poston, K. L., Chahine, L. M., Weintraub, D., Tanner, C. M., Gonzalez-Latapi, P., Kopil, C. M., Xiao, Y., Chowdhury, S., Dam, T., Pagano, G., Stephenson, D., Siderowf, A., Dunn, B., Marek, K., on behalf of the Parkinsons Progression Markers Initiative
10.1101/2024.12.17.24319172 — Posted: 2024-12-23
Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson's disease
Gaertner, Z., Oram, C., Schneeweis, A., Schonfeld, E., Bolduc, C., Chen, C., Dombeck, D. A., Parisiadou, L., Poulin, J. F., Awatramani, R.
10.1101/2024.06.06.597807 — Posted: 2024-12-22
Anxa1+ dopamine neuron vulnerability defines prodromal Parkinson's disease bradykinesia and procedural motor learning impairment
Mantas, I., Contestabile, A., Skara, V., Loiseau, C., Santos, I., Cramb, K., Filograna, R., Wade-Martins, R., Magill, P., Meletis, K.
10.1101/2024.12.22.629963 — Posted: 2024-12-22
The gut microbiome promotes mitochondrial respiration in the brain of a Parkinson's disease mouse model
Morais, L. H., Stiles, L., Freeman, M., Oguienko, A. D., Hoang, J. D., Jones, J., Quan, B., Devine, J., Bois, J. S., Chou, T.-F., Trinh, J., Picard, M., Gradinaru, V., Mazmanian, S. K.
10.1101/2024.12.18.629251 — Posted: 2024-12-21

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