Channel:  Francis Crick Institute

1,183 Articles

C9orf72 polyGA knock-in mice exhibit mild motor and proteomic changes consistent with ALS/FTD
Milioto, C., Carcole, M., Zanovello, M., Ahmed, M., Nirujogi, R. S., Biggs, D., Katona, E., Glaria, I., Santos, A., Devoy, A., Fratta, P., Alessi, D. R., Davies, B., Greensmith, L., Fisher, E., Isaacs, A. M.
10.1101/2025.05.30.656994 — Posted: 2025-06-02
Lysosomal stress induces amyloid-β aggregate release and reactive transformation in human astrocytes
Goldsworthy, S., Fertan, E., Dyal, P., Domoney, S., Livesey, F., Klenerman, D., Patani, R., Hung, C.
10.1101/2025.05.27.656416 — Posted: 2025-06-01
Beneficial and detrimental consequences of AHR activation in intestinal infection
Diaz, O. P., zhou, L., Barrington, C., Lindquist, D., Graelmann, F., Wincent, E., Stockinger, B.
10.1101/2025.05.28.656570 — Posted: 2025-06-01
The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis
Roeselova, A., Shivakumaraswamy, S., Jurkeviciute, G., He, J.-Z., Auburger, J., Schmitt, J., Kramer, G., Bukau, B., Enchev, R. I., Balchin, D.
10.1101/2025.05.27.656346 — Posted: 2025-05-30
The penetrant chordoid glioma PRKCA mutation is an oncogenic gain-of-function kinase inactivation eliciting early onset chondrosarcoma in mice.
Calleja, v., Henry, J. C., Cobbaut, M., Sewell, J., Rizzoti, K., Houghton, F., Boeing, S., Anyanwu, N., Varsani-Brown, S., Snoeks, T., Suarez-Bonnet, A., Priestnall, S. L., McDonald, N. Q., Cameron, A. J., Parker, P. J.
10.1101/2025.05.28.656646 — Posted: 2025-05-29
Gene network architecture, mutation and selection collectively drive developmental pattern evolvability and predictability
Booth, H., Hadjivasiliou, Z.
10.1101/2024.12.23.630099 — Posted: 2025-05-29
Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data
Fontaine, M., Vives, M. J. D., Saez, M., Maizels, R., Finnie, E., Briscoe, J., Rand, D. A.
10.1101/2025.05.28.656648 — Posted: 2025-05-28
RAD51AP1 is a versatile RAD51 modulator
Kuhlen, L., Argunhan, B., Liang, P., Zhong, J., Masino, L., Zhang, X.
10.1101/2025.05.24.655746 — Posted: 2025-05-24
Protein Kinase C δ: a critical hub regulating macrophage immunomodulatory functions during Mycobacterium tuberculosis infection
Hazra, R., Ozturk, M., Peton, N., Ganief, T., Poswayo, S. K., Rousseau, R. P., Naidoo, S., Jones, S.-S., Savulescu, A. F., Moseki, R., Abhimanyu, A., Plessis, N. D., Blackburn, J., Mhlanga, M. M., Kahn, C. R., Brombacher, F., Wilkinson, R. J., Parihar, S. P.
10.1101/2025.05.19.653976 — Posted: 2025-05-23
CRITICAL ROLE OF ADULT-BORN DENTATE GRANULE NEURONS IN PATTERN COMPLETION
roullet, p., Koehl, M., Delage, P., Guillemot, F., Abrous, N.
10.1101/2025.05.15.654267 — Posted: 2025-05-20

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