Channel:  Francis Crick Institute

1,190 Articles

Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome
Bacic, L., Gaullier, G., Sabantsev, A., Lehmann, L., Brackmann, K., Dimakou, D., Halic, M., Hewitt, G., Boulton, S. J., Deindl, S.
10.1101/2021.06.18.448936 — Posted: 2021-06-18
Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243A>G mtDNA mutation
Chung, C.-Y., Singh, K., Kotiadis, V. N., Valdebenito, G. E., Ahn, J. H., Topley, E., Tan, J., Andrews, W. D., Bilanges, B., Pitceathly, R. D. S., Szabadkai, G., Yuneva, M., Duchen, M. R.
10.1101/2020.06.18.159103 — Posted: 2021-06-14
Principles of ecDNA random inheritance drive rapid genome change and therapy resistance in human cancers
Lange, J. T., Chen, C. Y., Pichugin, Y., Xie, F., Tang, J., Hung, K. L., Yost, K. E., Shi, Q., Erb, M. L., Rajkumar, U., Wu, S., Swanton, C., Liu, Z., Huang, W., Chang, H. Y., Bafna, V., Henssen, A. G., Werner, B., Mischel, P. S.
10.1101/2021.06.11.447968 — Posted: 2021-06-11
Tumor cell total mRNA expression shapes the molecular and clinical phenotype of cancer
Cao, S., Wang, J. R., Ji, S., Yang, P., Montierth, M. D., Guo, S., Shen, J. P., Zhao, X., Chen, J., Lee, J. J., Guerrero, P. A., Spetsieris, N., Engedal, N., Taavitsainen, S., Yu, K., Livingstone, J., Bhandari, V., Hubert, S. M., Daw, N. C., Futreal, A., Efstathiou, E., Lim, B., Viale, A., Zhang, J., Nykter, M., Czerniak, B. A., Msaouel, P., Maitra, A., Kopetz, S., Campbell, P., Speed, T. P., Boutros, P. C., Zhu, H., Urbanucci, A., Demeulemeester, J., Van Loo, P., Wang, W.
10.1101/2020.09.30.306795 — Posted: 2021-06-09
Eosinophils are an integral component of the pulmonary granulocyte response in Tuberculosis and promote host resistance in mice
Bohrer, A. C., Castro, E., Hu, Z., Queiroz, A. T. L., Tocheny, C. E., Assmann, M., Sakai, S., Nelson, C., Baker, P. J., Ma, H., Wang, L., Zilu, W., du Bruyn, E., Riou, C., Kauffman, K. D., Tuberculosis Imaging Program, , Moore, I. N., Del Nonno, F., Petrone, L., Goletti, D., Martineau, A. R. R., Lowe, D. M., Cronan, M. R., Wilkinson, R. J., Barry, C. E., Via, L. E., Barber, D. L., Klion, A. D., Andrade, B. B., Song, Y., Wong, K.-W., Mayer-Barber, K. D.
10.1101/2021.05.29.446277 — Posted: 2021-05-31
Mechanistic insights into RNA binding and RNA-regulated RIG-I ubiquitination by TRIM25
Haubrich, K., Augsten, S., Alvarez, L., Huppertz, I., Simon, B., Perez, K., Masiewicz, P., Lethier, M., Rittinger, K., Gabel, F., Hentze, M. W., Cusack, S., Hennig, J.
10.1101/2020.05.04.070177 — Posted: 2021-05-30
Neural stem cells alter nucleocytoplasmic partitioning and accumulate nuclear polyadenylated transcripts during quiescence
Rossi, A., Coum, A., Madelenat, M., Harris, L., Miedzik, A., Strohbuecker, S., Chai, A., Fiaz, H., Chaouni, R., Faull, P., Grey, W., Bonnet, D., Hamid, F., Makeyev, E. V., Snijders, A. P., Kelly, G., Guillemot, F., Sousa-Nunes, R.
10.1101/2021.01.06.425462 — Posted: 2021-05-29
Notch controls the cell cycle to define leader versus follower identities during collective cell migration.
Alhashem, Z., Feldner-Busztin, D., Revell, C., Alvarez-Garcillan Portillo, M., Richardson, J., Rocha, M., Gauert, A., Corbeaux, T., Prince, V. E., Bentley, K., Linker, C.
10.1101/2021.05.27.445572 — Posted: 2021-05-27
Automatic instance segmentation of mitochondria in electron microscopy data
Nightingale, L., de Folter, J., Spiers, H., Strange, A., Collinson, L. M., Jones, M. L.
10.1101/2021.05.24.444785 — Posted: 2021-05-24
SMCHD1 has separable roles in chromatin architecture and gene silencing that could be targeted in disease
Tapia del Fierro, A., den Hamer, B., Jansz, N., Chen, K., Beck, T., Vanyai, H., Benetti, N., Gurzau, A. D., Daxinger, L., Xue, S., Nguyen Ly, T. T., Wanigasuriya, I., Breslin, K., Oey, H., Krom, Y., van der Hoorn, D., Bouwman, L. F., Ritchie, M. E., Reversade, B., Prin, F., Mohun, T., van der Maarel, S. M., McGlinn, E., Murphy, J. M., Keniry, A., de Greef, J. C., Blewitt, M. E.
10.1101/2021.05.12.443934 — Posted: 2021-05-18

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