Channel:  Francis Crick Institute

1,153 Articles

Combining RASG12C(ON) inhibitor with SHP2 inhibition sensitises immune excluded lung tumours to immune checkpoint blockade: a strategy for turning cold tumours hot
Anastasiou, P., Moore, C., Rana, S., de Castro, A., Tomaschko, M., Boumelha, J., Mugarza, E., Blaj, C., de Carne Trecesson, S., Goldstone, R., Smith, J., Quintana, E., Molina-Arcas, M., Downward, J.
10.1101/2024.01.15.575765 — Posted: 2024-01-30
The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir
Dinh, T., Tber, Z., Rey, J. S., Mengshetti, S., Annamalai, A. S., Haney, R., Briganti, L., Amblard, F., Fuchs, J. R., Cherepanov, P., Kim, K., Schinazi, R. F., Perilla, J. R., Kim, B., Kvaratskhelia, M.
10.1101/2024.01.26.577387 — Posted: 2024-01-26
Smad4 is essential for epiblast scaling and morphogenesis after implantation, but nonessential prior to implantation in the mouse
Kruger, R., Frum, T., Brumm, A. S., Hickey, S. L., Niakan, K., Aziz, F., Shammami, M., Roberts, J., Ralston, A.
10.1101/2024.01.23.576717 — Posted: 2024-01-24
Mechanism of chaperone coordination during cotranslational protein folding in bacteria
Roeselova, A., Maslen, S. L., Shivakumaraswamy, S., Pellowe, G. A., Howell, S., Joshi, D., Redmond, J., Kjaer, S., Skehel, M., Balchin, D.
10.1101/2024.01.22.576655 — Posted: 2024-01-23
Deciphering the diversity and sequence of extracellular matrix and cellular spatial patterns in lung adenocarcinoma using topological data analysis
Yoon, I. H. R., Jenkins, R., Colliver, E., Zhang, H., Novo, D., Moore, D., Ramsden, Z., Rullan, A., Fu, X., Yuan, Y., Harrington, H. A., Swanton, C., Byrne, H. M., Sahai, E.
10.1101/2024.01.05.574362 — Posted: 2024-01-17
Four-Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage
Panten, J., Del Prete, S., Cleland, J. P., Saunders, L. M., van Riet, J., Schneider, A., Ginno, P. A., Schneider, N., Koch, M.-L., Gerstung, M., Stegle, O., Turner, J. M. A., Heard, E., Odom, D. T.
10.1101/2023.12.04.569933 — Posted: 2024-01-17
Single cell RNA-seq reveals protracted germ line X chromosome reactivation dynamics directed by a PRC2 dependent mechanism
Liu, Y., Lau, X., Munusamy, P., Sanchez, C. A. S., Snell, D., Sangrithi, M.
10.1101/2023.11.06.565813 — Posted: 2024-01-16
A scaleable inducible knockout systemfor studying essential gene function inthe malaria parasite
Ramaprasad, A., Blackman, M.
10.1101/2024.01.14.575607 — Posted: 2024-01-15
Quantifying spectral information about source separation in multisource odour plumes
Tootoonian, S., True, A. C., Crimaldi, J. P., Schaefer, A. T.
10.1101/2024.01.14.575605 — Posted: 2024-01-15
Targeting the Plasmodium falciparum UCHL3 ubiquitin hydrolase using chemically constrained peptides
King, H. R., Bycroft, M., Nguyen, T.-B., Kelly, G., Vinogradov, A. A., Rowling, P. J., Stott, K., Ascher, D. B., Suga, H., Itzhaki, L. S., Artavanis-Tsakonas, K.
10.1101/2024.01.11.575158 — Posted: 2024-01-13

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