Channel:  Francis Crick Institute

1,351 Articles

A combined program of induced stemness and differentiation in response to interferon gamma drives acute myeloid leukaemia growth
Pospori, C., Donada, A., Boutzen, H., Grey, W., Rabas, N., Kassara, N., Sun, W., Birch, F., Georgiou, C., Gibson, S., Yong, A. A., Karoutas, A., Rizou, T., Vassiliadis, D., Stevens, G., Williams, T. J., Khorshed, R., Haltalli, M., Murison, A., Skoufou, M.-N., Sloan, K., Encabo, H., Hopkins, J., Christodoulidou, C., Rondriguez-Hernandez, I., Chakravarty, P., Stampoulis, D., Atkinson, S., Hearn-Yeates, F., Polizou, K., Trompouki, E., Burt, R., Innes, A., Stauss, H., Chakraverty, R., Xie, S. Z., Dawson, M., Dick, J., Malanchi, I., Bonnet, D., Lo Celso, C.
10.64898/2026.09.09.750099 — Posted: 2026-09-10
Multi-Species, Genome-Wide Metabolic Network Reconstructions Reveal the Basis for Metabolic Versatility in Mycobacteria
Cancino Aguirre, I., Priya, M., Garza-Garcia, A., de Carvalho, L. P. S., de Jong, H., Ropers, D.
10.64898/2026.09.02.748904 — Posted: 2026-09-04
Cholesterol and p53 promote senescence and systemic fibrosis in metabolic dysfunction-associated steatohepatitis
Wittke, C. I., Watt, D. M., Butler, L., Lyons, A. M., Clarke, C. J., Mullen, C., Clements, N., Lawlor, A., Athineos, D., Young, A., Strathdee, D. J., Nixon, C., Nelson, L. J., Bird, T. G., Vousden, K. H., Blyth, K., Crowe, J., Humpton, T. J.
10.64898/2026.09.02.748892 — Posted: 2026-09-03
iClima: a ratiometric genetically encoded sensor for optical imaging of fast GABAergic chloride currents in vitro and in vivo
Pasquini, G., Giubbolini, S., Nardi, G., Brondi, M., Beyene, E., Balsi, C., Egidi, A., Tsushima Semini, H., Landi, S., Stancampiano, M., Beale, A. D., Watson, E. M., Edgar, R. S., ONeill, J. S., Arosio, D., Santi, M., Fassio, A., Lodovichi, C., Ratto, G. M.
10.64898/2026.05.27.728254 — Posted: 2026-09-02
A COJEC-chemotherapy resistant model of Th-ALK(F1174L)/MYCN neuroblastoma offers insights into tumour immune evasion and development of the bone marrow metastatic niche
Tucker, E. R., Lampis, A., Househam, J., Roberts, D., Barker, K., Martins da Costa, B., Greenslade, K., Mayfield, S., Lorenzi, F., Thorley, E., Tandon, V., Han, N. S., Emanuelli, G., Bourdim, M., Martin, G., Willumsen, N., Pannone, M., Pryce, J., Angelini, P., Yuneva, M., Graham, T., George, S. L., Chesler, L.
10.64898/2026.09.01.743331 — Posted: 2026-09-02
Thymic keratin76 shapes skin-specific central tolerance
Gelmetti, M., Tomas, I. M., Ragazzini, R., Campinoti, S., Soon, M. S. F., Cautela, M., Vietri Rudan, M., Torre, M., Sumaria, N., Saldanha, I., Pereira, D., Yap, N., Efremova, M., Tuong, Z. K., Watt, F. M., Bonfanti, P., Pennington, D. J., Sequeira, I.
10.64898/2026.08.27.747460 — Posted: 2026-08-31
Single-cell mapping of the fallopian tube reveals a genomically unstable secretory cell state enriched in carriers of germline BRCA1/2 mutations
Eyal-Lubling, Y., Vias, M. D., Kania, K., Kaludova, D., Hall, J., Crawford, R., Nyagumbo, R., Ward, S., Khoronenkova, S., Aparicio, S., Swanton, C., Jimenez Linan, M., Brenton, J. D., Correia Martins, F.
10.64898/2026.08.26.746998 — Posted: 2026-08-27
Piezo1 balances focal and reticular adhesions to enable EGFR clathrin-mediated endocytosis
Bagudanch, O., Zoroa, O., Ayala, V., Midyan, R., Bagley, D. C., Moparthi, S. B., Hakanpää, L., Lenaerts, A.-S., Almeida-Souza, L., Munoz, F. J., Valverde, M. A., Vassilopoulos, S., Rosenblatt, J., Pardo-Pastor, C.
10.64898/2026.08.21.746250 — Posted: 2026-08-24
Symbolic regression enables coarse-grained model discovery of intracellular signalling dynamics
de Pomereu, T., Fröhlich, F.
10.64898/2026.08.20.745973 — Posted: 2026-08-21
Chromosomal instability shapes spatial and temporal phenotypic diversity in a malignant peripheral nerve sheath tumour
Yan, H., Demeulemeester, J., Verfaillie, A., Cheng, Y., Pan, Y., Cotobal Martin, C., Ward, S., Stein, A., Lesluyes, T., Kaufmann, T., Schwarz, R. F., Voet, T., Swanton, C., Zaccaria, S., Flanagan, A. M., Tarabichi, M., Van Loo, P.
10.64898/2026.08.13.744699 — Posted: 2026-08-21

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