Channel:  Impact of Genomic Variation on Function (IGVF)

232 Articles

cellSTAAR: Incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of non-coding regions
Van Buren, E., Zhang, Y., Li, X., Selvaraj, M. S., Li, Z., Zhou, H., Palmer, N. D., Arnett, D. K., Blangero, J., Boerwinkle, E., Cade, B. E., Carlson, J. C., Carson, A. P., Chen, Y.-D. I., Curran, J., Duggirala, R., Fornage, M., Franceschini, N., Graff, M., Gu, C., Guo, X., He, J., Heard-Cosa, N., Hou, L., Hung, Y.-J., Kalyani, R. R., Kardia, S. L. R., Kooperberg, C., Kral, B. G., Lange, L., Li, C., Liu, S., Lloyd-Jones, D., Loos, R. J. F., Manichaikul, A. W., Martin, L. W., Mathias, R., Minster, R., Mitchell, B. D., Mychaleckyj, J. C., Naseri, T., North, K., O'Connell, J., Perry, J. A., Peyse
10.1101/2025.04.23.650307 — Posted: 2025-04-26
Systematic cell-type resolved transcriptomes of 8 tissues in 8 lab and wild-derived mouse strains captures global and local expression variation
Rebboah, E., Weber, R., Abdollahzadeh, E., Swarna, N. P., Sullivan, D. K., Trout, D., Reese, F., Liang, H. Y., Filimban, G., Mahdipour, P., Duffield, M., Mojaverzargar, R., Taghizadeh, E., Fattahi, N., Mojgani, N., Zhang, H., Loving, R. K., Carilli, M., Booeshaghi, A. S., Kawauchi, S., Hallgrimsdottir, I. B., Williams, B. A., MacGregor, G., Pachter, L., Wold, B., Mortazavi, A.
10.1101/2025.04.21.649844 — Posted: 2025-04-24
Defining effective strategies to integrate multi-sample single-nucleus ATAC-seq datasets via a multimodal-guided approach
Weinand, K., Langan, E. M., Curtis, M., Raychaudhuri, S.
10.1101/2025.04.02.646871 — Posted: 2025-04-03
Redirecting cytotoxic lymphocytes to breast cancer tumors via metabolite-sensing receptors
Kim, Y. M., Akana, R., Sun, C., Laveroni, O., Jerby, L.
10.1101/2025.03.21.644686 — Posted: 2025-03-25
Landscapes of missense variant impact for human superoxide dismutase 1
Axakova, A., Ding, M. X., Cote, A. G., Subramaniam, R., Senguttuvan, V., Zhang, H., Weile, J., Douville, S. V., Gebbia, M., Al-Chalabi, A., Wahl, A., Reuter, J., Hurt, J., Mitchell, A., Fradette, S., Andersen, P. M., van Loggerenberg, W., Roth, F. P.
10.1101/2025.02.25.640191 — Posted: 2025-02-28
Geospatially informed representation of spatial genomics data with SpatialFeatureExperiment
Moses, L., Huseynov, A., Rich, J., Pachter, L.
10.1101/2025.02.24.640007 — Posted: 2025-02-27
Early and late RNA eQTL are driven by different genetic mechanisms
Sakaue, S., Accelerating Medicines Partnership: RA/SLE Network, , Raychaudhuri, S.
10.1101/2025.02.24.639351 — Posted: 2025-02-26
SpaFun: Discovering Domain-specific Spatial Expression Patterns and New Disease-Relevant Genes using Functional Principal Component Analysis
Jiang, X., Guo, Y., Guo, L., Zhong, L., Wang, J., Xiao, G., Li, Q., Xu, L.
10.1101/2025.02.17.638766 — Posted: 2025-02-21
Mapping the regulatory effects of common and rare non-coding variants across cellular and developmental contexts in the brain and heart
Marderstein, A. R., Kundu, S., Padhi, E. M., Deshpande, S., Wang, A., Robb, E., Sun, Y., Yun, C. M., Pomales-Matos, D., Xie, Y., Nachun, D., Jessa, S., Kundaje, A., Montgomery, S. B.
10.1101/2025.02.18.638922 — Posted: 2025-02-20
Clonal memory of colitis accumulates and promotes tumor growth
Nagaraja, S., Ojeda-Miron, L., Zhang, R., Oreskovic, E., Hu, Y., Zeve, D., Sharma, K., Hyman, R. R., Zhang, Q., Castillo, A., Breault, D. T., Yilmaz, O. H., Buenrostro, J. D.
10.1101/2025.02.13.638099 — Posted: 2025-02-17

RSS  Channel RSS