Channel:  Impact of Genomic Variation on Function (IGVF)

232 Articles

Monod: model-based discovery and integration through fitting stochastic transcriptional dynamics to single-cell sequencing data
Gorin, G., Chari, T., Carilli, M., Vastola, J. J., Pachter, L.
10.1101/2022.06.11.495771 — Posted: 2025-11-06
Large-scale discovery of neural enhancers for cis-regulation therapies
McDiarmid, T. A., Page, N. F., Chardon, F. M., Daza, R. M., Chen, G. T., Kosicki, M., James, L. M., Nourie, H. C., Laboy-Cintron, D., Lee, A. S., Vij, P., Calderon, D., Lalanne, J.-B., Martin, B. K., Fink, K., Talkowski, M. E., Muotri, A. R., Philpot, B. D., Pennacchio, L. A., Geschwind, D. H., Sanders, S. J., Ahituv, N., Shendure, J.
10.1101/2025.11.04.686611 — Posted: 2025-11-05
RELB Reprograms Exhausted Tumor-Infiltrating Lymphocytes for Improved Adoptive Cell Therapy
McRoberts Amador, C. D., Conover, R. E., Brown, M. C., Lyniv, L. S., Noldner, P. K., Zhou, Y., Gao, A. R., McCutcheon, S. R., Antonia, S. J., Gersbach, C. A.
10.1101/2025.10.11.681829 — Posted: 2025-10-12
Comprehensive profiling of transcription factors for reprogramming human astrocytes to neuronal cells through endogenous CRISPR-based gene activation
Reisman, S. J., Halabi, D., Miller, S. E., Song, L., Geraghty, S., Sangvai, N., Rice, G., Safi, A., Crawford, G. E., Gersbach, C. A.
10.1101/2025.10.11.681828 — Posted: 2025-10-12
Inherent instability of simple DNA repeats shapes an evolutionarily stable distribution of repeat lengths
McGinty, R. J., Balick, D. J., Mirkin, S. M., Sunyaev, S. R.
10.1101/2025.01.09.631797 — Posted: 2025-10-09
Base-editing a single missense mutation in A20 enhances CAR-T cell efficacy
Blaisdell, A., Bachl, S., Sandoval, L. R., Ching, C., Bowman, C. J., Kale, N., Prabandham, M., Diolaiti, M., Havig, C., Advincula, R., Lenci, N., Li, Z., Yamashita, E., Wang, C. H., Zhang, S., Liu, Q., Achacoso, P., Stibor, D., Oynebraten, I., Seo, J., Ashworth, A., Marson, A., Ye, C. J., Malynn, B. A., Eyquem, J., Carnevale, J., Ma, A.
10.1101/2025.10.05.680562 — Posted: 2025-10-06
Gradient-aware modeling advances AI-driven prediction of genetic perturbation effects
Jerby, L., Zhu, D.
10.1101/2025.10.03.680360 — Posted: 2025-10-05
Segregating DNA lesions point to high selective advantage of tumor initiating cells
Seplyarskiy, V., Shady, M., Andrianova, M. A., Chapman, M. S., Van Allen, E., Sunyaev, S. R.
10.1101/2025.10.02.680094 — Posted: 2025-10-04
Uniform processing and analysis of IGVF massively parallel reporter assay data with MPRAsnakeflow
Rosen, J. D., Vasanthakumari, A. D., Salomon, K., de Lange, N., Dash, P. M., Keukeleire, P., Hassan, A., Barrera, A., Kircher, M., Love, M. I., Schubach, M.
10.1101/2025.09.25.678548 — Posted: 2025-09-29
Sensitive, direct detection of non-coding off-target base editor unwinding and editing in primary cells
Wang, T., Jessa, S., Marinov, G. K., Klemm, S., Kundaje, A., Greenleaf, W. J.
10.1101/2025.09.25.678665 — Posted: 2025-09-25

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