Channel:  Impact of Genomic Variation on Function (IGVF)

232 Articles

Gene regulatory network structure informs the distribution of perturbation effects
Aguirre, M., Spence, J. P., Sella, G., Pritchard, J. K.
10.1101/2024.07.04.602130 — Posted: 2024-10-22
SPLENDID incorporates continuous genetic ancestry in biobank-scale data to improve polygenic risk prediction across diverse populations
Chen, T., Zhang, H., Mazumder, R., Lin, X.
10.1101/2024.10.14.618256 — Posted: 2024-10-17
BIT: Bayesian Identification of Transcriptional Regulators from Epigenomics-Based Query Region Sets
Lu, Z., Xu, L., Wang, X.
10.1101/2024.06.02.597061 — Posted: 2024-10-08
Optimizing and benchmarking polygenic risk scores with GWAS summary statistics
Zhao, Z., Gruenloh, T., Yan, M., Wu, Y., Sun, Z., Miao, J., Wu, Y., Song, J., Lu, Q.
10.1101/2022.10.26.513833 — Posted: 2024-09-25
Calibration of additional computational tools expands ClinGen recommendation options for variant classification with PP3/BP4 criteria
Bergquist, T., Stenton, S. L., Nadeau, E. A. W., Byrne, A. B., Greenblatt, M. S., Harrison, S. M., Tavtigian, S. V., O'Donnell-Luria, A., Biesecker, L. G., Radivojac, P., Brenner, S. E., Pejaver, V., ClinGen Sequence Variant Interpretation Working Group
10.1101/2024.09.17.611902 — Posted: 2024-09-21
CRISPR-CLEAR: Nucleotide-Resolution Mapping of Regulatory Elements via Allelic Readout of Tiled Base Editing
Becerra, B., Wittibschlager, S., Patel, Z. M., Kutschat, A., Delano, J., Karjalainen, A., Wu, T., Starrs, M., Jankowiak, M., Bauer, D., Seruggia, D., Pinello, L.
10.1101/2024.09.09.612085 — Posted: 2024-09-09
Mutagenesis Sensitivity Mapping of HumanEnhancers In Vivo
Kosicki, M., Zhang, B., Pampari, A., Akiyama, J. A., Playzer-Frick, I., Novak, C. S., Tran, S., Zhu, Y., Kato, M., Hunter, R. D., von Maydell, K., Barton, S., Beckman, E., Kundaje, A., Dickel, D. E., Visel, A., Pennacchio, L. A.
10.1101/2024.09.06.611737 — Posted: 2024-09-08
Characterization and bioinformatic filtering of ambient gRNAs in single-cell CRISPR screens using CLEANSER
Liu, S., Hamilton, M. C., Cowart, T. N., Barrera, A., Bounds, L. R., Nelson, A. C., Doty, R. W., Allen, A. S., Crawford, G. E., Majoros, W. H., Gersbach, C. A.
10.1101/2024.09.04.611293 — Posted: 2024-09-04
BayeSMART: Bayesian Clustering of Multi-sample Spatially Resolved Transcriptomics Data
Guo, Y., Zhu, B., Tang, C., Rong, R., Ma, Y., Xiao, G., Xu, L., Li, Q.
10.1101/2024.08.30.610571 — Posted: 2024-09-01
Parallel genome-scale CRISPR-Cas9 screens uncouple human pluripotent stem cell identity versus fitness
Rosen, B. P., Li, Q. V., Cho, H. S., Liu, D., Yang, D., Graff, S., Yan, J., Luo, R., Verma, N., Damodaran, J. R., Kale, H. T., Kaplan, S. J., Beer, M. A., Sidoli, S., Huangfu, D.
10.1101/2023.05.03.539283 — Posted: 2024-09-01

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