date is show_cat.php
Select an archive month  
July 2025
June 2025
May 2025
April 2025
March 2025
February 2025
January 2025
December 2024
November 2024
October 2024
September 2024
August 2024
July 2024
June 2024
May 2024
April 2024
March 2024
February 2024
January 2024
December 2023
November 2023
October 2023
September 2023
August 2023
July 2023
June 2023
May 2023
April 2023
March 2023
February 2023
January 2023
December 2022
November 2022
October 2022
September 2022
August 2022
July 2022
June 2022
May 2022
April 2022
March 2022
February 2022
January 2022
December 2021
November 2021
October 2021
September 2021
August 2021
July 2021
June 2021
May 2021
April 2021
March 2021
February 2021
January 2021
December 2020
November 2020
October 2020
September 2020
August 2020
July 2020
June 2020
May 2020
April 2020
March 2020
February 2020
January 2020
December 2019
November 2019
October 2019
September 2019
August 2019
July 2019
June 2019
May 2019
April 2019
March 2019
February 2019
January 2019
December 2018
November 2018
October 2018
September 2018
August 2018
July 2018
June 2018
May 2018
April 2018
March 2018
February 2018
January 2018
December 2017
November 2017
October 2017
September 2017
August 2017
July 2017
June 2017
May 2017
April 2017
March 2017
February 2017
January 2017
December 2016
November 2016
October 2016
September 2016
August 2016
July 2016
June 2016
May 2016
April 2016
March 2016
February 2016
January 2016
December 2015
November 2015
October 2015
September 2015
August 2015
July 2015
June 2015
May 2015
April 2015
March 2015
February 2015
January 2015
December 2014
November 2014
October 2014
September 2014
August 2014
July 2014
June 2014
May 2014
April 2014
March 2014
February 2014
January 2014
December 2013
November 2013

Archive, 2025-07

12 A comprehensive EEG dataset for investigating visual touch perception
Smit, S.; Ramirez-Haro, A.; Varlet, M.; Moerel, D.; Quek, G.; Grootswagers, T.
10.1101/2025.07.10.664069 — neuroscience — Posted on 2025-07-16
15 Inhibition of therapy-resistant and metastatic melanoma by targeting the translation initiation complex
Feng, Y.; Diaz Olea, X.; Radaeva, M.; Amiri, M.; Joo, H.; Kim, H.; Ke, X.; Deshpande, A.; Olson, S.; Jovanovic, P.; Pass, I.; Deng, Q.; Lazar, I.; Murad, R.; Molinolo, A.; Sergienko, E.; Villaneuva, J.; Topisirovic, I.; Jackson, M.; Ferrone, C.; Sonenberg, N.; Cherkasov, A.; Ronai, Z. A.
10.1101/2024.11.20.624566 — cancer biology — Posted on 2025-07-16
17 Marker-independent imaging reveals a correlation of fibrotic and epigenetic alterations in endometriosis
Beyer, T.; Becker, L.; Demir, S.; Liebscher, S.; Carvajal Berrio, D. A.; Boesmueller, H.; Rall, K.; Kraemer, B.; Brucker, S. Y.; Schenke-Layland, K.; Weiss, M.; Marzi, J.
10.1101/2025.07.10.664232 — biophysics — Posted on 2025-07-16
20 High-fat circulating nutrients promote growth and invasion in a 3D microfluidic tumor model of triple-negative breast cancer
Kohram, M.; Yuste, C. T.; Brennan-Smith, M. C.; Salazar, E. S. N.; Zhang, P.; Hao, J. E.; Xu, X.; Chavre, B.; Oh, W.; Zhang, S. X.; Leggett, S. E.; Ryseck, R.-P.; Rabinowitz, J. D.; Nelson, C. M.
10.1101/2025.07.10.664224 — bioengineering — Posted on 2025-07-16
21 A Singular Base Editing Platform for Polyfunctional Multiplex Engineering of Immune Cells
Skeate, J. G.; Slipek, N. J.; Lahr, W. S.; Roy, S.; Wick, B. J.; Stelljes, E. M.; Gilkey, A. K.; Thenge, P. P.; Diers, M. D.; Kar, B.; Krueger, J. B.; Niemeyer, E. M.; Lonetree, C.-l.; Kluesner, M. G.; Bell, J. B.; Clement, K.; Provenzano, P.; Moriarity, B. S.; Webber, B. R.
10.1101/2025.07.11.664404 — bioengineering — Posted on 2025-07-16
22 OptoChaperone - A biohybrid tool for regulating protein condensates in cells and in vitro
Tuan, D. T.; Matsusaki, M.; Ota, H.; Kawagoe, S.; Isozumi, N.; Kumeta, H.; Ishimori, K.; Mori, E.; Saio, T.
10.1101/2025.07.15.665009 — biochemistry — Posted on 2025-07-16
23 A versatile enzymatic pathway for modification of peptide C-termini
Dommaraju, S. R.; Kandy, S. K.; Ren, H.; Luciano, D. P.; Fujiki, S.; Sarlah, D.; Zhao, H.; Chekan, J. R.; Mitchell, D. A.
10.1101/2025.07.11.664356 — biochemistry — Posted on 2025-07-16
24 Dynamic convergence of neurodevelopmental disorder risk genes across neurodevelopment
Fernandez Garcia, M.; Retallick-Townsley, K.; Pruitt, A.; Davidson, E.; Balafkan, N.; Warrell, J.; Huang, T.-C.; Kibowen, A.; Chu, Z.; Dai, Y.; Fitzpatrick, S. E.; Meng, R.; Sen, A.; Cohen, S.; Livoti, O.; Khan, S.; Becker, C.; Luiz Teles Silva, A.; Liu, J.; Dossou, G.; Cheung, J.; Liu, S.; Ghorbani, S.; Deans, P. J. M.; DeCiucis, M.; Emani, P.; Gao, H.; Shen, H.; Gerstein, M.; Wang, Z.; Huckins, L.; Hoffman, E.; Brennand, K.
10.1101/2024.08.23.609190 — genetics — Posted on 2025-07-16
25 Estrogens protect bone mass by inhibiting NAD+ metabolism in osteoclasts
Kim, H.-N.; Marques-Carvalho, A.; Adam, G. O.; Chalke, A.; Resende-Coelho, A.; Reyes-Castro, O.; Warren, A.; Grilo, L.; Chini, C. N.; Stronach, B.; Alturkmani, F.; Ambrogini, E.; Chini, E. N.; Almeida, M.
10.1101/2025.07.11.664289 — molecular biology — Posted on 2025-07-16
26 Self-Reactive B Cells in Artery Tertiary Lymphoid Organs Encode Pathogenic High Affinity Autoantibody in Atherosclerosis
Zhang, C.; Zhang, X.; Ran, Y.; Wang, Z.; Li, L.; Wang, S.; Zheng, J.; Zhang, Y.; Sun, T.; Li, Y.; Lu, S.; Hong, M.; Ma, Z.; Steffens, S.; Hristov, M.; Blanchet, X.; Dornmair, K.; Hu, D.; Lahiri, S.; Imhof, A.; Sachs, N.; Maegdefessel, L.; Xiao, J.; Zhang, J.; Wang, Y.; Hong, H.; Habenicht, L.; Weber, C.; Santovito, D.; Bashford-Rogers, R. J. M.; Mohanta, S. K.; Ley, K.; Habenicht, A. J. R.; Yin, C.
10.1101/2025.07.10.664251 — immunology — Posted on 2025-07-16
27 Fully Automated and Scalable Pipeline for Macaque Brain Registration
Zhuo, J.; Zhang, Z.; Xiao, C.; Wang, M.; Bi, S.; Shi, L.; Luo, Q.; Gong, H.; Shen, Z.; Yang, X.; Li, P.
10.1101/2025.07.10.663842 — neuroscience — Posted on 2025-07-16
28 ConvNeXt-Driven Detection of Alzheimers Disease: A Benchmark Study on Expert-Annotated AlzaSet MRI Dataset Across Anatomical Planes
Basereh, M.; Abikenari, M. A.; Sadeghzadeh, S.; Dunn, T.; Freichel, R.; Siddarth, P.; Ghahremani, D.; Lavretsky, H.; Buch, V. P.
10.1101/2025.07.10.664260 — neuroscience — Posted on 2025-07-16
31 Membrane-anchored PrPSc is the trigger for prion synaptotoxicity
Gatdula, J. R. P.; Mercer, R. C. C.; Vultaggio, J. S.; Harris, D. A.
10.1101/2025.07.11.664221 — neuroscience — Posted on 2025-07-16
34 Stabilin levels are related to atherosclerotic plaque burden in type 2 diabetes mellitus individuals
Giannousi, E.; Georgiadou, C.; Kassi, E.; Vlachogiannis, N.; Aggeli, I. K.; Sfikakis, P. P.; Tentolouris, N.; Protogerou, A. D.; Kararigas, G.; Chatzigeorgiou, A.
10.1101/2025.07.10.664255 — physiology — Posted on 2025-07-16
35 PIWIL2 downregulation in colon cancer promotes transposon activity and pro-tumorigenic phenotypes
Risner, A.; Nair-Menon, J.; Cheedipudi, A.; Delaney, J. R.; Gangaraju, V.; Kourtidis, A.
10.1101/2025.05.20.655197 — cancer biology — Posted on 2025-07-16
36 Controlling treatment toxicity in ovarian cancer to prime the patient for tumor extinction therapy
Gallagher, K.; Sousa, R. S.; Gatenbee, C. D.; Schenck, R.; Chen, P.; Citak, T.; Leither, S.; Mazzacurati, L.; Xella, A.; Zhou, Z.; Lemanne, D.; Rodriguez, P.; George, E.; Strobl, M. A. R.
10.1101/2025.07.10.664235 — cancer biology — Posted on 2025-07-16
40 Formulation and Characterization of Primary Tissue-Derived Microfluidic Droplet-Engineered Organoids
Wang, W.; Cai, Y.; Dai, X.; Yang, H.; Khutsishvili, D.; Li, J.; Zhu, Y.; Wang, J.; Yan, X.; Wang, Z.; Ma, S.
10.1101/2025.07.10.664241 — bioengineering — Posted on 2025-07-16
41 UniversalEPI: robust prediction of cell type-specific and differential chromatin interactions from DNA sequence and chromatin accessibility
Grover, A.; Zhang, L.; Muser, T.; Häfliger, S.; Wang, M.; Yates, J.; Indilewitsch, M.-C.; Van Allen, E.; Theis, F. J.; Ibarra, I. L.; Krymova, E.; Boeva, V.
10.1101/2024.11.22.624813 — genomics — Posted on 2025-07-16
42 A mathematical framework for human neutrophil state transitions inferred from single-cell RNA sequence data
Wigerblad, G.; Carruthers, J.; Ray, S.; Finnie, T.; Lythe, G.; Molina-Paris, C.; Pyne, S.; Kaplan, M.
10.1101/2025.06.27.662068 — cell biology — Posted on 2025-07-16
43 Detection of low pre-existing humoral immunity against influenza virus H5N1 clade 2.3.4.4b in unexposed individuals
Daniel, K.; Ullrich, L.; Ruchnewitz, D.; Meijers, M.; Halwe, N. J.; Wild, U.; Eberhardt, J.; Schöne, J.; Stumpf, R.; Schlotz, M.; Wunsch, M.; Girao Lessa, L.; Abd El-Whab, E.-S. M.; Kuryshko, M.; Dietrich, C.; Pinger, A.; Schumacher, A.-L.; Germer, M.; Rohde, M.; Kukat, C.; Gieselmann, L.; Gruell, H.; Hoffmann, D.; Beer, M.; Erren, T.; Lässig, M.; Kreer, C.; Klein, F.
10.1101/2025.01.22.634277 — immunology — Posted on 2025-07-16
44 Spatiotemporal brain complexity quantifies consciousness outside of perturbation paradigms
Breyton, M.; Fousek, J.; Rabuffo, G.; Sorrentino, P.; Kusch, L.; Massimini, M.; Petkoski, S.; Jirsa, V.
10.1101/2023.04.18.537321 — neuroscience — Posted on 2025-07-16
46 Thriving Across Depths: How Blue Light Shapes a Large PSI Supercomplex and Specific Photosynthetic Traits in the seagrass Posidonia oceanica.
Charras Ferroussier, Q.; Mathiot, C.; Semchonok, D. A.; Elias, E.; Bhatti, A. F.; Lebrun, R.; Guillemain, D.; Siponen, M.; Croce, R.; Jungas, C.
10.1101/2025.06.20.660723 — plant biology — Posted on 2025-07-16
48 Delta Marches to autonomously learn histopathology rules by generative latent space traversals
Nguyen, T. H.; Panwar, V.; Jarmale, V.; Perny, A.; Dusek, C.; Cai, Q.; Kapur, P. H.; Danuser, G.; Rajaram, S.
10.1101/2025.03.18.643999 — bioinformatics — Posted on 2025-07-16
55 Mosaic of Somatic Mutations in one of Earth's Largest Organism, Pando
Pineau, R.; Mock, K. E.; Morris, J. L.; Kraklow, V.; Brunelle, A.; Pageot, A.; Ratcliff, W. C.; Gompert, Z.
10.1101/2024.10.19.619233 — evolutionary biology — Posted on 2025-07-16
56 Sterols regulate ciliary membrane dynamics and hedgehog signaling in health and disease
Eguether, T.; Lamaziere, A.; kozlowski, l.; Ayala-Sanmartin, J.; Farhat, M.; Belaid, N.; Certain, A.; Isidor, B.; Besnard, T.; Trugnan, G.; Pazour, G. J.; Despres, G.; Deseille, C.; Moreno, S.
10.1101/2025.07.15.664899 — cell biology — Posted on 2025-07-16
57 Epigenetic delineation of the earliest cardiac lineage segregation by single-cell multi-omics
Xie, P.; Jiang, X.; He, J.; Pan, Q.; Yang, X.; Zheng, Y.; Fan, W.; Wu, C.; Zheng, W.; Fang, K.; Si, S.; Zhu, S.; Yang, Y.; Zhong, T. P.; Yang, Z.; Wei, K.; Xie, W.; Jing, N.; Luo, Z.; Lin, C.
10.1101/2024.05.17.594655 — molecular biology — Posted on 2025-07-16
58 ETS-guided iPSC-endothelial models recapitulate malaria pathogenesis
Korbmacher, F.; Fleckenstein, H.; Long, R. K. M.; Polinski, P.; Piatti, L.; Lopez Gutierrez, B.; Batzilla, A.; Crusius, D.; Trivedi, V.; Ebisuya, M.; Bernabeu, M.
10.1101/2025.07.01.662615 — microbiology — Posted on 2025-07-16
59 Genetic Reinstatement of RIG-I in Chickens Reveals Insights into Avian Immune Evolution and Influenza Interaction
Sid, H.; von Heyl, T.; Schleibinger, S.; Klinger, R.; Heyemelot Nabel, L.; Vikkula, H. K.; Guabiraba, R.; Guillory, V.; Scicluna, R.; Alhussien, M. M.; Boehm, B.; Schade, B.; Elleder, D.; Sives, S.; Vervelde, L.; Trapp, S.; Schusser, B.
10.1101/2023.11.01.564710 — immunology — Posted on 2025-07-16
61 Blood-brain-barrier permeable fluorescent astrocyte probes.
Gunawardhana, N.; Cervasio, D.; Singh, S.; Haputhanthrige-Don, O.; Laughlin, S. T.
10.1101/2025.07.10.664185 — neuroscience — Posted on 2025-07-16
67 Early changes in the properties of CA3 engram cells explored with a novel viral tool
Cupolillo, D.; Grosjean, N.; Marneffe, C.; Viotti, J.; Reynaud, C.; Deforges, S.; Carta, M.; Mulle, C.
10.1101/2024.11.29.625977 — neuroscience — Posted on 2025-07-16
68 Modelling perceptual uncertainty in a thermosensory illusion across the lifespan
Ehmsen, J. F.; Mitchell, A. G.; Kraenge, C. E.; Courtin, A. S.; Simonnet, C.; Fardo, F.
10.1101/2025.07.10.664158 — neuroscience — Posted on 2025-07-16
71 Identification of cellular and molecular risk signatures for progression to late-stage age-related macular degeneration using the 9-step Minnesota Grading System
Huang, C.-L.; Qiu, Y.; Demirs, J. T.; Wu, X.; Twarog, M.; Delgado, O.; Crowley, M.; Buchanan, N.; Vo, N.; Fan, L.; Wang, Y.; Yang, J.; Vollmer, T. R.; Klokman, G.; Jose, S.; Aranda, J.; Prasanna, G.; Poor, S.; Grosskreutz, C. L.; Olsen, T. W.; Wilson, C. W.; Saint-Geniez, M.; Liao, S.-M.
10.1101/2025.07.10.664209 — neuroscience — Posted on 2025-07-16
75 Modelling Inflammatory Endothelial Dysfunction: A Human In Vitro Platform for Translational Research
Cheremkhina, M.; Babendreyer, A.; Neullens, C. T.; Krapp, S.; Pabst, A.; Ohl, K.; Ruetten, S.; Ludwig, A.; Cornelissen, C. G.; Jockenhoevel, S.; Tenbrock, K.; Thiebes, A. L.
10.1101/2023.10.31.564901 — bioengineering — Posted on 2025-07-16
77 Foxi1 regulates multipotent mucociliary progenitors and ionocyte specification through transcriptional and epigenetic mechanisms
Bowden, S.; Brislinger-Engelhardt, M. M.; Hansen, M.; Andricek, A.; Temporal Plo, A.; Weber, D.; Haegele, S. L.; Lorenz, F.; Litwin, T.; Kreutz, C.; Walentek, P.
10.1101/2024.10.27.620464 — developmental biology — Posted on 2025-07-16
80 Proteasome Inhibition Reduces NBR1 Protein Levels in mATG8-Deficient Cells Independently of Lysosomal Degradation and RAB27A
Cerda-Troncoso, C.; Arias-Munoz, E.; Vargas, G.; Gaete-Ramirez, M.; Cereceda, K.; Cavieres, V. A.; Burgos, P. V.
10.1101/2025.07.15.664987 — cell biology — Posted on 2025-07-16
81 Exomer cooperates with Ryh1RAB6 in regulating TORC2 activity
Moscoso-Romero, E. J.; Moro, S.; Shiozaki, K.; Valdivieso, M.- H.
10.1101/2025.07.15.664877 — cell biology — Posted on 2025-07-16
86 Prediction of cellular morphology change under perturbations with transcriptome-guided diffusion model
Wang, X.; Fan, Y.; Guo, Y.; Fu, C.; Lee, K.; Dallakyan, K.; Li, Y.; Yin, Q.; Li, Y.; Song, L.
10.1101/2025.07.16.665106 — cell biology — Posted on 2025-07-16
89 Brain-heart coupling shapes large scale brain dynamics
Sonkusare, S.; Iyer, K. K.; Hearne, L. J.; Phogat, R.; van der Meer, J. N.; Dionisio, S.; Shine, J.; Breakspear, M.
10.1101/2025.07.14.664815 — neuroscience — Posted on 2025-07-16
91 Multi-omics integration reveals sex-based differences in the circulating extracellular vesicle lipidome and miRNome of alcohol use disorder patients
Perpina-Clerigues, C.; Mellado, S.; Galiana-Rosello, C.; Kodikara, S.; Martin-Urdiales, B.; Marcos, M.; Le Cao, K.-A.; Garcia-Garcia, F.; Pascual, M.
10.1101/2025.07.15.664861 — bioinformatics — Posted on 2025-07-16
92 Gene model for the ortholog of tgo in Drosophila pseudoobscura
Lawson, M. E.; Suriaga, J. M.; Rowland, M. B.; Reed, L. K.; Rele, C. P.; Wittke-Thompson, J. K.
10.1101/2025.07.13.664599 — genomics — Posted on 2025-07-16
96 Kandinsky: enabling neighbourhood analysis of spatial omics data for functional insights on cell ecosystems
Andrei, P.; Grieco, M.; Acha-Sagredo, A.; Dhami, P.; Fung, K.; Rodriguez-Justo, M.; Cereda, M.; Ciccarelli, F. D.
10.1101/2025.07.10.664141 — bioinformatics — Posted on 2025-07-16
97 Gut microbiota of dogs with cancer receiving anti-EGFR/HER2 immunization reveals potential biomarkers of patient survival
Rodrigues, R. R.; Karumuru, V.; Nuss, S.; Elliott, M.; Shriver, I.; Chao, C.-M.; Doyle, H. A.; Tripp, C.; Mamula, M. J.; Dzutsev, A.; Morgun, A.; Shulzhenko, N.
10.1101/2025.07.13.663784 — cancer biology — Posted on 2025-07-16
98 piqtree: A Python Package for Seamless Phylogenetic Inference with IQ-TREE
McArthur, R. N.; Wong, T. K. F. N.; Lang, Y.; Morris, R. A.; Caley, K.; Mallawaarachchi, V.; Minh, B. Q.; Huttley, G. A.
10.1101/2025.07.13.664626 — bioinformatics — Posted on 2025-07-16
100 Response to "No evidence that transmissible cancer has shifted from emergence to endemism in Tasmanian devils"
Storfer, A.; Margres, M. J.; Kozakiewicz, C. P.; Hamede, R.; Ruiz-Aravena, M.; Hamilton, D. G.; Comte, S.; Stadler, T.; Leache, A.; McCallum, H.; Jones, M. E.; Hohenlohe, P. A.
10.1101/2025.07.14.664746 — evolutionary biology — Posted on 2025-07-16
101 Investigating the antibacterial and anti-biofilm activity of agave syrup as a traditional wound remedy
Pallett, R.; Pritchard, K.; Wikins, K.; Galleh, R.; Adebisi, O.; Harman, L. A.; Momi, T.; Wilkes, H.; Dodds Pennock, C.
10.1101/2025.07.13.664611 — microbiology — Posted on 2025-07-16
102 Paratyphoid Fever and Relapsing Fever in 1812 Napoleon's Devastated Army
Barbieri, R.; Fumey, J.; Kabral, H.; Scheib, C. L.; Signoli, M.; Costedoat, C.; Rascovan, N.
10.1101/2025.07.12.664512 — microbiology — Posted on 2025-07-16
109 Blastocoel fluid RNA predicts pregnancy outcome in assisted reproduction
Frisendahl, C.; Gemzell-Danielsson, K.; Nair, K.; Koch, F.; Menezes, J.; Sheikhi, M.; Dahlgren, K.; Alnahal, W.; Lindgren, K.; Bohlin, T.; Olofsson, J. I.; Tohonen, V.; Vafaee, F.; Grace, L. P.; Boggavarapu, N. R.; Faridani, O. R.
10.1101/2025.03.09.641486 — molecular biology — Posted on 2025-07-15
112 CDK8 remodels the tumor microenvironment to resist the therapeutic efficacy of targeted KRASG12D inhibition in pancreatic ductal adenocarcinoma
McAndrews, K. M.; Mahadevan, K. K.; Li, B.; Sockwell, A. M.; Morse, S. J.; Kelly, P. J.; Patel, S. I.; Kirtley, M. L.; Diaz, B. A. M.; Lyu, H.; Peng, D. H.; Zhou, X.; Sugimoto, H.; Sthanam, L. K.; Conner, M. R.; Kumbhar, S. V.; Arian, K. A.; Barekatain, Y.; Paradiso, F.; Guerrero, P. A.; Bernard, V.; Sobhani, N.; Camacho-Acevedo, A. N.; Bornes, K. E.; Tran, P. T.; Maitra, A.; Heffernan, T. P.; Kalluri, R.
10.1101/2025.01.29.635543 — cancer biology — Posted on 2025-07-15
114 Does Sequence Clustering Confound AlphaFold2?
Wayment-Steele, H. K.; Ovchinnikov, S.; Colwell, L.; Kern, D.
10.1101/2024.07.29.605333 — biophysics — Posted on 2025-07-15
115 SMURF Reconstructs Single-Cells from Visium HD Data to Reveal Zonation of Transcriptional Programs in the Intestine
Guo, J.; Sarafinovska, S.; Hagenson, R.; Valentine, M.; Dougherty, J.; Mitra, R. D.; Muegge, B. D.
10.1101/2025.05.28.656357 — genomics — Posted on 2025-07-15
117 Human activities drive novel behaviours and transitions in dolphins
Samad, I.; Patil, H.; Cantor, M.; Farine, D.; Sutaria, D.; Shanker, K.
10.1101/2025.07.10.663819 — ecology — Posted on 2025-07-15
121 Synthetic α-synuclein fibrils replicate in mice causing MSA neuropathology
Burger, D.; Kashyrina, M.; van den Heuvel, L.; de La Seigliere, H.; Lewis, A. J.; De Nuccio, F.; Mohammed, I.; Verchere, J.; Feuillie, C.; Berbon, M.; Arotcarena, M.-L.; Retailleau, A.; Bezard, E.; Canron, M.-H.; Meissner, W. G.; Loquet, A.; Bousset, L.; Poujol, C.; Nilsson, P.; Laferriere, F.; Baron, T.; Lofrumento, D. D.; De Giorgi, F.; Stahlberg, H.; Ichas, F.
10.1101/2024.07.01.601498 — neuroscience — Posted on 2025-07-15
124 A Canonical Microcircuit for Estimating Excitation/Inhibition (E/I) Balance
Hauke, D. J.; Rodriguez-Sanchez, J.; Oloye, H.; Berndt, L. C. S.; Pinotsis, D.; Friston, K. J.; Mathalon, D. H.; Adams, R. A.
10.1101/2025.07.10.664116 — neuroscience — Posted on 2025-07-15
125 Benchmarking methods for genome annotation using Nanopore direct RNA in a non-model crop plant
Davis, J. M.; Gagalova, K. K.; Vincis Pereira Sanglard, L. M.; Cuellar, S.; Gibberd, M. R.; Naim, F.
10.1101/2025.07.14.664836 — bioinformatics — Posted on 2025-07-15
128 Learning Universal Representations of Intermolecular Interactions with ATOMICA
Fang, A.; Desgagne, M.; Zhang, Z.; Zhou, A.; Loscalzo, J.; Pentelute, B. L.; Zitnik, M.
10.1101/2025.04.02.646906 — bioinformatics — Posted on 2025-07-15
132 The Tip60 acetylome is a hallmark of the proliferative state in Drosophila
Apostolou, Z.; Venkatasubramani, A. V.; Kopp, L. C.; Kars, G.; Scacchetti, A.; Sparr, A. C.; Schauer, T.; Imhof, A.; Becker, P. B.
10.1101/2025.07.15.664872 — molecular biology — Posted on 2025-07-15
133 Activity-targeted metaproteomics enhances the ecophysiological characterization of cryptic syntrophic metabolisms
Friedline, S.; McDaniel, E.; Scarborough, M.; Madill, M.; Waring, K.; Lin, V. S.; Malmstrom, R. R.; Goudeau, D.; Chrisler, W.; Dueholm, M. K.; Gorham, L. J.; Kombala, C. J.; Griggs, L. H.; Olson, H. M.; Lehmann, S.; Munoz, N.; Trejo, J.; Tolic, N.; Pasa-Tolic, L.; William, S.; Lipton, M.; Hallam, S. J.; Ziels, R.
10.1101/2025.07.15.664484 — microbiology — Posted on 2025-07-15
134 From Colonisation to Invasion: Genomic and Phenotypic Comparison of Faecal and Bloodstream Isolates from the same patients
Khanijau, A.; Allman, E.; Pulmones, R.; Goodman, R. N.; McGalliard, R.; Parry, C. N.; Carrol, E. D.; Roberts, A. P.
10.1101/2025.07.15.664880 — microbiology — Posted on 2025-07-15
135 The dengue virus NS1 protein alters Aedes aegypti midgut permeability and favors virus dissemination
Quezada-Ruiz, E.; Silva-Olivares, A.; Talamas-Lara, D.; Diaz, G.; Alanis-Munoz, S.; Cruz, R.; Betanzos, A.; Hernandez-Martinez, S.; Lanz-Mendoza, H.; Ludert, J. E.
10.1101/2025.07.15.663935 — microbiology — Posted on 2025-07-15
138 Optogenetic stimulation of nigral astrocytes is neuroprotective in a 6-OHDA model of neurodegeneration.
McNeill, J.; Trujillo-Pisanty, I.; Simard, S.; Groulx, C.; Rudyk, C.; Hayley, S.; Faiz, M.; Tomlinson, J.; Schlossmacher, M.; Coppola, G.; Salmaso, N.
10.1101/2025.07.10.664169 — neuroscience — Posted on 2025-07-15
139 A 3D iPSC retina model reveals non-cell-autonomous and non-neuronal mechanism of photoreceptor degeneration in a lysosomal storage disorder.
Han, J.; Foley, N.; Dalvi, S.; Tang, J. A. H.; Chatterjee, A.; Kumar, L. K.; Galloway, C. A.; Singh, K.; Subedi, Y.; Ling, K.; Heffer, A.; LIbby, R. T.; Benoit, D. S. W.; Cook, A. L.; Bonilha, V. L.; Gullapalli, V.; Schuchman, E.; Hunter, J. J.; Singh, R.
10.1101/2025.07.10.664233 — neuroscience — Posted on 2025-07-15
141 Engineering Microbial R- and S- β-Hydroxybutyrate Production
Kizil, B. C.; Ulusan, S.; Torun, A.; Gumustas, M.; Yuksel, S.; Banerjee, S.
10.1101/2025.07.15.664879 — synthetic biology — Posted on 2025-07-15
143 Design of a Multi-Epitope Vaccine using β-barrel Outer Membrane Proteins Identified in Chlamydia trachomatis
Panda, A.; Kapoor, J.; Hareramadas, B.; Naqvi, I.; Ganta, S.; Chhabra, R.; Kumar, S.; Bandyopadhyay, A.
10.1101/2025.07.10.664186 — bioinformatics — Posted on 2025-07-15
145 Structural and enzymatic divergence between human MDH isoforms underlies their specialized regulatory roles in metabolism
Berndsen, C. E.; Kayll, A. J.; Rahman, R.; Tester, J. R.; Beaver, T.; tuck, C.; Neve-Hoversten, S.; Gentile, L.; Mandanis, T.; Provost, J. J.
10.1101/2025.07.15.665002 — biochemistry — Posted on 2025-07-15
147 SETD2 methyltransferase activity aids gene definition by promoting correct transcription initiation and termination
Nakayama, C.; Kopczynska, M.; Stepien, A.; Ito, S.; Imami, K.; Gdula, M. R.; Nojima, T.; Kamieniarz-Gdula, K.
10.1101/2025.07.14.664659 — molecular biology — Posted on 2025-07-15
148 Extracellular vesicles and their RNA cargo facilitate bidirectional cross-kingdom communication between human and bacterial cells
Groeger, L.; Rishik, S.; Ludwig, N.; Beganovic, A.; Koch, M.; Rheinheimer, S.; Hart, M.; Koenig, P.; Trampert, T.; Paul, P.; Boese, A.; Lehr, C.-M.; Becker, S. L.; Fuhrmann, G.; Keller, A.; Meese, E.
10.1101/2025.07.10.664124 — molecular biology — Posted on 2025-07-15
150 Conformations and sequence determinants in the lipid binding of an adhesive peptide derived from Vibrio cholerae biofilm
Huang, X.; Prasad, R.; Saluja, S.; Yang, Y.; Yan, Q.; Shuster, S. O.; Olson, R.; Lin, C.; Davis, C. M.; Jiang, X.; Zhou, H.-X.; Yan, J.
10.1101/2025.07.14.664771 — microbiology — Posted on 2025-07-15
151 Bioluminescent reporter influenza A viruses to track viral infections
Barre, R. S.; Mostafa, A.; Chiem, K.; Pearl, R. L.; Platt, R. N.; Cupic, A.; Anderson, T. J.; Knaus, U. G.; Albrecht, R. A.; Garcia-Sastre, A.; Kobie, J.; Nogales, A.; Martinez-Sobrido, L.
10.1101/2025.07.15.664884 — microbiology — Posted on 2025-07-15
154 Reproducible detection of antigen-specific T cells and Tregs via standardized and automated activation-induced marker assay workflows
Halvorson, T.; Boucher, G.; Yokosawa, D.; Huang, J. Q.; Garcia, R.; Sanderink, L.; Chen, L.; Liu, L.; Fajardo-Despaigne, J. E.; Halvorson, J.; Brinkman, R.; Vercauteren, S.; Lesage, S.; Bramson, J.; Rioux, J. D.; Ivison, S.; Levings, M. K.
10.1101/2025.07.15.664847 — immunology — Posted on 2025-07-15
155 Inactivation of NMDAR and CaMKII signaling within the prelimbic cortex blocks incubated cocaine- and sucrose-craving
Huerta Sanchez, L. L.; Siao, N. M.; Chaudhari, S. R.; Barrios, J. E.; Na, A. Y.; Tadros, M. G.; McConnell, M. L.; Kaplan, R. M.; Lane, C. R.; Doan, H. H. T.; Liger, A. B.; Chou, T. C.; Marcon, S.; Cano, F. J.; Kippin, T. E.; Szumlinski, K. K.
10.1101/2025.07.10.664193 — neuroscience — Posted on 2025-07-15
156 Maternal smoking in early pregnancy disrupts placental function through syncytiotrophoblast and macrophage dysregulation.
Valdes, D. S.; Nimo, J.; Nonn, O.; Ulrich, J.; Forstner, D.; Haider, S.; Ressler, M.; Pignitter, M.; Muller, D. N.; Dechend, R.; Gauster, M.; Coscia, F.; Herse, F.
10.1101/2025.07.10.664172 — systems biology — Posted on 2025-07-15
157 Heterotypic Protein Interactions Modulate the Condensate Dynamics and Aggregation of α-Synuclein
Roychowdhury, S.; Paul, S.; Sojitra, K.; Bhattacharya, S.; Mazumder, A.; Mittal, J.; Chattopadhyay, K.
10.1101/2025.07.10.664163 — biophysics — Posted on 2025-07-15
158 Predicting Future SARS-CoV-2 Mutations using Deep Learning
Ayaz, H.; Ibrahimzada, A. R.; Adebali, O.; Fejzullahu, A.; Azgari, C.; Baysan, M.; Buyukbingol, M. E.; Demir, G.; Karlik, E.; Ozpolat, B.; CAKMAK, A.
10.1101/2025.07.12.664533 — bioinformatics — Posted on 2025-07-15
162 Expression and Purification of Full-Length hnRNPA2B1 for Biophysical Characterization of Liquid-Liquid Phase Separation
Duran-Armenta, L. F.; Meszaros, A.; Pueyo, J. M.; Janvier, S.; Lazar, T.; Maes, D.; Loris, R.; Tompa, P.
10.1101/2025.07.10.664112 — biochemistry — Posted on 2025-07-15
167 α5-GABA-A Receptor Positive Allosteric Modulation prevents neuronal atrophy and cognitive decline independently of p-Tau accumulation in the PS19 mouse model
Dharavath, R. N.; Bernardo, A.; Marceau-Linhares, C.; Marcotte, M.; Mezo-Gonzalez, C. E.; Wong, K.; Pina-Leblanc, C.; Bouchet, A.; Sharmin, D.; Pandey, K. P.; Cook, J.; Pandey, K. P.; Prevot, T. D.; Sibille, E.
10.1101/2024.09.07.611810 — neuroscience — Posted on 2025-07-15
170 Type 2 Deiodinase in Cancer-Associated Fibroblasts is required to sustain growth of poorly and undifferentiated thyroid cancer
De Stefano, M. A.; Luongo, C.; Porcelli, T.; Cervone, C.; Spezia, S.; Misso, C.; Cerbone, V.; Carillo, A. M.; Troncone, G.; Schlumberger, M.; Salvatore, D.
10.1101/2025.07.10.664131 — cancer biology — Posted on 2025-07-15
172 Systemic Inflammation Modulates Clearance and drives Extra-Hepatic Distribution of Extracellular Vesicles
Pavlova, S.; Mamand, D.; Gorgens, A.; Zickler, A.; Zheng, W.; Liang, X.; Wiklander, O.; Abedi-Valugerdi, M.; Wonterghem, E.; Xie, J.; Niu, Z.; Roudi, S.; Yan, D.; Zhou, G.; Imami, K.; Wood, M.; Vanderbroucke, R.; El Andaloussi, S.; Gupta, D.
10.1101/2025.07.10.664102 — bioengineering — Posted on 2025-07-15
173 Comparative clinical transcriptome of pir genes in severe Plasmodium vivax malaria
Boopathi, P. A.; Singh, S.; Roy, P.; Tahbildar, S.; Kochar, S. K.; Kochar, D. K.; Kumar Das, A.
10.1101/2025.07.10.664071 — genomics — Posted on 2025-07-15
174 Newly-identified lentil genotypes adapted to Mediterraneanagro-ecosystems
Rocchetti, L.; Frimponga, A. K.; Vittori, V. D.; Santamarina, C.; Pieri, A.; Tosoroni, A.; Papalini, S.; Francioni, F.; Musari, E.; Bellucci, E.; Nanni, L.; Marzario, S.; Logozzo, G.; Gioia, T.; Bett, K.; Arlotti, G.; Silvestri, M.; Papa, R.; Bitocchi, E.
10.1101/2025.07.10.664142 — genetics — Posted on 2025-07-15
180 Unravelling hidden trophic interactions among sea urchin juveniles and macroinvertebrates by DNA amplification
Sutera, A.; Bonaviri, C.; Di Trapani, F.; La Bella, F.; Macic, V.; Markovic, O.; Hereu, B.; De Michele, R.
10.1101/2025.07.10.664104 — ecology — Posted on 2025-07-15
183 Autonomous Reef Monitoring Structures (ARMS) Reveal Human-Induced Biodiversity Shifts in Urban Coastal Ecosystems
WAN, Z.; Guibert, I.; Chung, W. Y. H.; Ho, C.; Au, W. C. R.; Brennan, J. B.; Chan, L. F. M.; Chei, E.; Conti-Jerpe, I.; Corley, A.; Cybulski, J. D.; Hayden, R.; Lee, S. Y. J.; McLeod, W.; Tompson, P.; McIlroy, S. E.; Baker, D. M.
10.1101/2025.07.11.664282 — ecology — Posted on 2025-07-15
184 Spatial overlap of sea ice-associated predators and prey in western Hudson Bay
Warret Rodrigues, C.; Derocher, A. E.; Roth, J. D.; McGeachy, D.; Pilfold, N. W.
10.1101/2025.07.11.664287 — ecology — Posted on 2025-07-15
186 An immunobiliary single-cell atlas resolves crosstalk of type 2 cDCs and γδT cells in cholangitis
Thomann, S.; Hemmer, H.; Agrawal, A.; Basu, S.; Schaf, J.; Sagar, S.; Imdahl, F.; Poth, T.; Toth, M.; Zielinski, C. E.; Poch, T.; Krause, J.; Rosenwald, A.; Breitkopf-Heinlein, K.; Rahbari, N.; Grün, D.
10.1101/2025.07.10.664083 — immunology — Posted on 2025-07-15
189 MrgD Receptor Modulates Neurotransmission in the Nigrostriatal Pathway
Rodrigues-Ribeiro, L. R. A.; Oliveira, B. d. S.; Santos, K. S. B.; Machado, C. A.; Nawrocki, A.; dos Santos, M. J. C.; de Miranda, A. S.; Guatimosim, C.; Larsen, M. R.; dos Santos, R. A. S.; Verano-Braga, T.
10.1101/2025.07.10.664011 — neuroscience — Posted on 2025-07-15
191 Bridging laboratory and field research: method adjustments to manipulate field-derived Aedes aegypti
Gendrin, M.; Epelboin, Y.; Ortega-Lopez, L. D.; Balthazar, E.; Cornement, A.; Guidez, A.; Dusfour, I.
10.1101/2025.07.10.664070 — zoology — Posted on 2025-07-15
201 Vascularized Bioengineered Kidney Using Decellularized Scaffold Recellularized with human Placenta-Derived Angiogenic stem Cells and Kidney Organoids
Liu, H.; Wen, X.; Shi, Y.; Zhou, Y.; Chen, X.; Song, W.; Zhang, X.; Wang, Y.; Hao, J.; Ma, Y.; Zhang, J.; Cai, Y.; Gong, Y.; Lin, F.; Du, X.; XU, J.
10.1101/2025.07.10.664023 — bioengineering — Posted on 2025-07-15
205 Phylogenetic analysis of paired breast carcinomas identifies genetic events associated with clonal recurrence and invasive progression
Kader, T.; Zethoven, M.; Mahale, S.; Saunders, H.; Tjoeka, L.; Lehmann, R.; Jayawardane, M.; Pang, J.-M.; Lesche, D.; Rajan, N.; Semple, T.; Lee, J. E. A.; Lupat, R.; Byrne, D. J.; Hughes, S.; Nguyen, H.; Lai, S.; Pechlivanis, M.; Craig, O.; Devereux, L.; House, E.; Jayasinghe, S. I.; Kaufmann, T. L.; Schwarz, R. F.; Green, A. R.; Miligy, I.; Cummings, M.; Lakhani, S.; Campbell, I. G.; Rakha, E.; Fox, S. B.; Mann, G. B.; Gorringe, K. L.
10.1101/2024.05.19.594731 — cancer biology — Posted on 2025-07-15
206 Blue-shifted ancyromonad channelrhodopsins for multiplex optogenetics
Govorunova, E. G.; Sineshchekov, O. A.; Li, H.; Gou, Y.; Chen, H.; Yang, S.; Wang, Y.; Mitchell, S.; Palmateer, A.; S. Brown, L. S.; St-Pierre, F.; Xue, M. G.; Spudich, J. L.
10.1101/2025.02.24.639930 — biochemistry — Posted on 2025-07-15
207 Functional impact of pathogenic Runt domain mutations in Runx2 on skeletal and dental development in cleidocranial dysplasia
Ogawa, S.; Higuchi, S.; Yoshimoto, Y.; Hoshino, M.; Miura, S.; Hamada, A.; Watanabe, H.; Sakuma, T.; Hu, K.; Ogata, S.; Uchibe, K.; Fujimoto, K.; Yamamoto, T.; Okamoto, T.; Kunimatsu, R.; Sotomaru, Y.; Tanimoto, K.; Kondoh, G.; Komori, T.; Docheva, D.; Shukunami, C.
10.1101/2025.06.18.660258 — genetics — Posted on 2025-07-15
209 Ribosomal RNA synthesis by RNA polymerase I is subject to premature termination of transcription.
Azouzi, C.; Schwank, K.; Queille, S.; Kwapisz, M.; Aguirrebengoa, M.; Henras, A.; Lebaron, S.; Tschochner, H.; Lesne, A.; Beckouet, F.; Gadal, O.; DEZ, c.
10.1101/2023.11.27.568781 — molecular biology — Posted on 2025-07-15
210 Whole-body connectome of a segmented annelid larva
Veraszto, C.; Jasek, S.; Gühmann, M.; Bezares-Calderon, L. A.; Williams, E.; Shahidi, R.; Jekely, G.
10.1101/2024.03.17.585258 — neuroscience — Posted on 2025-07-15
214 Hair cell population integrity necessary to preserve vestibular function
Schenberg, L.; Simon, F.; Palou, A.; Dijan, C.; Tagliabue, M.; Llorens, J.; Beraneck, M.
10.1101/2025.03.19.644154 — neuroscience — Posted on 2025-07-15
215 Transcriptomic assessment of the Black Judaicus scorpion (Hottentotta judaicus) toxin arsenal and its potential bioeconomic value
Lueddecke, T.; Dresler, J.; Hurka, S.; Wang, Y.; Pohler, T.; Simone, Y.; Kraemer, J.; Vilcinskas, A.; Herzig, V.
10.1101/2025.07.09.664027 — zoology — Posted on 2025-07-15
217 The role of Platelet-derived growth factor (PDGF) in uremic vascular calcification.
Yesilyurt Ozturk, B.; Zhang, L.; von Stillfried, S.; Klinkhammer, B. M.; Mollmann, J.; Droste, P.; Buhl, E. M.; Hohl, M.; Noels, H.; Jankowski, V.; Jankowski, J.; Goettsch, C.; Marx, N.; Olson, L.; Jurgen, F.; Wong, D. W. L.; Boor, P.
10.1101/2025.07.09.664016 — systems biology — Posted on 2025-07-15
219 Dynamic of the transcriptomic landscape of OsHV-1 replication in haemocytes of Pacific oyster
Dotto-Maurel, A.; Le Luyer, J.; Faury, N.; Degremont, L.; Tragin, M.; Renault, T.; MORGA, B.; Chevignon, G.
10.1101/2025.07.11.664376 — bioinformatics — Posted on 2025-07-15
220 Tracking breast cancer progression using Methylscape
Zhang, Z.; Ahmed, E.; Constantin, N.; Lu, J.; Korbie, D.; Wuethrich, A.; Sina, A.; Trau, M.
10.1101/2025.07.09.664004 — bioengineering — Posted on 2025-07-15
221 Harnessing P450 enzyme plasticity for generalizable peptide biaryl macrocyclization
Liu, R.; Pang, C.; Wu, G.; He, B.; Huang, B.; Ren, H.; Shen, Z.; Liu, J.; Zhiman, S.; Zhou, J.; Li, Y.-x.
10.1101/2024.10.06.616194 — biochemistry — Posted on 2025-07-15
222 Spatial Ecology of Jaguars in a Coastal Amazon Island Ecosystem
Silveira, L.; Jacomo, A. T. A.; Silveira, T. J.; de Araujo, G. R.; Moreira, R. A.; Palmeira, F. B. L.; Ferraz, M. d. A. M. M.; Noonan, M. J.
10.1101/2025.07.10.664043 — ecology — Posted on 2025-07-15
223 Interaction of HS1BP3 with cortactin modulates TKS5 localisation and cancer malignancy
Lochen, A. A.; Soreng, K.; Veroni, C.; Trachsel-Moncho, L.; Asp, N.; Gaupset, R.; Knaevelsrud, H.; Eftang, L.; Simonsen, A.
10.1101/2025.07.14.664640 — cell biology — Posted on 2025-07-15
224 Paralemmin-3 sustains the integrity of the lateral plasma membrane and subsurface cisternae of auditory hair cells
Halim, V. C.; Bahader, I.; Derstroff, D.; Ullrich, C.; Kuwabara, M.; Hultqvist, G.; Kusch, K.; Slitin, L.; Becker, L.; Hrabe de Angelis, M.; Wichmann, C.; Oliver, D.; Strenzke, N.; Vogl, C.; Kilimann, M.
10.1101/2025.07.11.664127 — cell biology — Posted on 2025-07-15
227 A chemically defined medium to support the growth of food-relevant Bacillus species
Canoy, T. S.; Wiedenbein, E. S.; McPhillips, C.; Jespersen, L.; Roder, H. L.; Nielsen, D. S.
10.1101/2025.07.14.664712 — microbiology — Posted on 2025-07-15
238 Refining sequence-to-activity models by increasing model resolution
Chandra, N. A.; Hu, Y.; Buenrostro, J.; Mostafavi, S.; Sasse, A.
10.1101/2025.01.24.634804 — genomics — Posted on 2025-07-15
243 Beta burst waveform extraction using novel 4He-OPMs
Gutteling, T. P.; Szul, M. J.; Daligault, S.; Labyt, E.; Jung, J.; Bonaiuto, J. J.; Schwartz, D. P.
10.1101/2025.07.10.663870 — neuroscience — Posted on 2025-07-15
246 Preserved cerebellar functions despite structural degeneration in older adults
de Witte, A.; Matthijs, A.; Parrell, B.; Mantini, D.; Gooijers, J.; Orban de Xivry, J.-J.
10.1101/2025.06.18.660418 — neuroscience — Posted on 2025-07-15
248 Fishexplorer: A multimodal cellular atlas platform for neuronal circuit dissection in larval zebrafish
Vohra, S. K.; Eberle, M.; Boulanger-Weill, J.; Petkova, M. D.; Schuhknecht, G. F. P.; Herrera, K. J.; Kämpf, F.; Ruetten, V. M. S.; Lichtman, J. W.; Engert, F.; Randlett, O.; Bahl, A.; Isoe, Y.; Hege, H.-C.; Baum, D.
10.1101/2025.07.14.664689 — neuroscience — Posted on 2025-07-15
249 Proteome profiling of plant Cajal bodies uncovers kingdom-specific components
Zhou, Y.; Tan, H.; Vicente-Luque, A.; Weis, M.; Wehinger, L.; Schreidl, M.; Droste-Borel, I.; Macek, B.; Berendzen, K. W.; Lozano-Duran, R.
10.1101/2025.07.10.664108 — plant biology — Posted on 2025-07-15
253 mamp-ml: A deep learning approach to epitope immunogenicity in plants
Stevens, D. M.; Yang, D.; Liang, T. J.; Li, T.; Vega, B.; Coaker, G.; Krasileva, K.
10.1101/2025.07.11.664399 — immunology — Posted on 2025-07-15
255 Role of the 5HT2C receptor in anxiety-like behavior in zebrafish (Danio rerio)
Oliveira, L. N.; Souza, L. V. X. d. B.; Bozi, B. S.; Costa, B. P. D.; Pantoja, A. R. B.; Lima-Maximino, M.; Ripardo, R. C.; Maximino, C.
10.1101/2025.07.11.664334 — neuroscience — Posted on 2025-07-15
260 Scalable human neuronal models of tauopathy producing endogenous seed-competent 4R tau
Tsefou, E.; Bez, S.; Birkle, T. J. Y.; Foiani, M.; Watamura, N.; Bourdenx, M.; Gavriouchkina, D.; Turkes, E.; Crawford, S.; Coneys, R.; Isaacs, A.; Duff, K.
10.1101/2025.07.11.664346 — neuroscience — Posted on 2025-07-15
261 Modular dynamics of conscious and unconscious states in marmoset cortex
Standage, D. I.; Hori, Y.; Nashed, J. Y.; Gale, D. J.; Menon, R. S.; Everling, S.; Gallivan, J. P.
10.1101/2025.07.09.663972 — neuroscience — Posted on 2025-07-15
262 Pde10a gates light responses in the SCN to regulate circadian photoentrainment
Komal, R.; Thomsen, M.; Wang, H.; Yang, S.; Tang, Q.; Zhao, H.; Hattar, S.
10.1101/2025.07.14.664763 — neuroscience — Posted on 2025-07-15
263 Honey bees (Apis mellifera) exhibit seasonal variation in their tolerance to viral infection
Payne, A. N.; St. Clair, A. L.; Harwood, G. P.; Prayugo, V.; Taylor, L. N.; Shapiro, M.; Dolezal, A. G.
10.1101/2025.07.11.664207 — pathology — Posted on 2025-07-15
268 RACLET: the Ramp Above Critical Level Endurance Test to evaluate critical force in isometric task.
Morel, B.; Bowen, M.; Vonderscher, M.; Blervaque, L.; Di Domenico, H.; Pernot, J.; Samozino, P.
10.1101/2025.07.11.664330 — biophysics — Posted on 2025-07-15
269 Mapping human cerebral blood flow with high-density, multi-channel speckle contrast optical spectroscopy
Kim, B.; Howard, A. C.; Cheng, T. Y.; Anderson, J. E.; Zimmermann, B.; Hazen, E.; Carlton, L.; Robinson, M.; Renna, M.; Yucel, M. A.; Carp, S.; Franceschini, M. A.; Boas, D. A.; Cheng, X.
10.1101/2025.03.03.638332 — bioengineering — Posted on 2025-07-15
272 Integrative Species Delimitation in a Speciation Continuum: Phylogenomics, Cryptic Diversity, Diversification and Historical Biogeography of Sinocyclocheilus Cavefish
Liu, Y.; Mao, T.; Zhou, J.; Zhou, S.; Peng, Y.; Sudasinghe, H.; Pethiyagoda, R.; Vasconcellos, M. M.; Pie, M. R.; Yang, J.; Meegaskumbura, M.
10.1101/2025.07.09.664015 — evolutionary biology — Posted on 2025-07-15
273 Implications of source-sink feedbacks for modelling tree carbon assimilation and growth
Friend, A. D.; Chen, Y.; Eckes-Shephard, A. H.; Fonti, P.; Hellmann, E.; Rademacher, T. T.; Richardson, A. D.; Thomas, P. R.
10.1101/2024.09.27.615358 — plant biology — Posted on 2025-07-15
276 Pharmacological inhibition of CXCR4 increases the anti-tumor activity of conventional and targeted therapies in B-cell lymphoma models
Barnabei, L.; Arribas, A. J.; Cascione, L.; Guidetti, F.; Spriano, F.; Tarantelli, C.; Di Cristofano, S.; Raniolo, S.; Rinaldi, A.; Stathis, A.; Rossi, D.; Zucca, E.; Limongelli, V.; Zimmermann, J.; Bertoni, F.
10.1101/2025.07.10.664047 — cancer biology — Posted on 2025-07-15
279 Task-specific topographic maps of neural activity in the primate lateral prefrontal cortex
Xiang, J. D.; Roussy, M.; Corrigan, B.; Gulli, R. A.; Luna, R.; Mofrad, M. H.; Muller, L.; Diedrichsen, J.; Schmitz, T. W.; Martinez-Trujillo, J.; Mur, M.
10.1101/2024.05.10.591729 — neuroscience — Posted on 2025-07-15
282 The SAFE Labs Handbook: Community-Driven Commitments for Group Leaders to Improve Lab Culture
Dona, E.; Gahan, J. M.; Lau, P.; Jeschke, J.; Ott, T.; Reinhard, K.; Sinigaglia, C.; Treur, J. L.; Vogl, T.; Bugeon, S.; Mariotti, L.; Rossi, F. F.; Coen, P.
10.1101/2025.05.27.655799 — scientific communication and education — Posted on 2025-07-15
287 Human airway organoids as a versatile model to study BSL-4 virus replication and pathogenesis
Wälzlein, J.-H.; Reusch, S.; Ospina-Garcia, J.; Olmer, R.; Schneider, M.; Klotz, L. V.; Klotz, C.; Kummer, S.
10.1101/2025.03.20.644281 — cell biology — Posted on 2025-07-15
288 RNA Polymerase II-mediated transcription is required for repair of ribosomal DNA breaks in nucleolar caps, guarding against genomic instability
Checa-Rodriguez, C.; Suarez-Quintero, B.; Contreras, L.; Korsholm, L.; Payne-Larsen, D. H.; de la Cruz Diaz, J.; Bartek, J.; Gomez-Cabello, D.
10.1101/2023.10.20.563274 — molecular biology — Posted on 2025-07-15
290 Circulating Chlamydia trachomatis-specific T Cell Immunity Reflects Widespread Exposure in South African Adolescents and Young Women
Bunjun, R.; Lurie, M.; Dabee, S.; Barnabas, S.; Maseko, V.; Jaumdally, S. Z.; Gamieldien, H.; Lewis, D. A.; Jaspan, H. B.; Gill, K.; Becker, L.-G.; Passmore, J.-A. S.
10.1101/2025.07.10.664075 — immunology — Posted on 2025-07-15
291 Connectomic reconstruction from hippocampal CA3 reveals spatially graded mossy fiber inputs and selective feedforward inhibition to pyramidal cells
Zheng, Z.; Park, C.; Hammerschmith, E. W.; Lu, R.; Yu, S.-C.; Sorek, M.; Silverman, B.; Jordan, C. S.; Sterling, A. R.; Silversmith, W. M.; Collman, F.; Seung, H. S.; Tank, D. W.
10.1101/2025.07.09.663979 — neuroscience — Posted on 2025-07-15
292 ALG13 loss-of-function alters glycosylation, impairs neuronal maturation, and drives network hypoactivity in a cortical organoid model of CDG
Shah, R.; Budhraja, R.; Radenkovic, S.; Preston, G.; King, A. T.; Sabry, S.; Bleukx, C.; Shammas, I.; Young, L.; Chandran, J.; Byeon, S. K.; Hrstka, R.; Smith, D. Y.; Staff, N. P.; Drake, R.; Sloan, S. A.; Pandey, A.; Morava, E.; Kozicz, T.
10.1101/2025.07.09.663964 — neuroscience — Posted on 2025-07-15
293 Reduced inter-subject functional connectivity during movies in autism: Replicability across cross-national fMRI datasets
Lin, F.; Albantakis, L.; Noppari, T.; Santavirta, S.; Brandi, M.-L.; Sun, L.; Lukkarinen, L.; Tani, P.; Salmi, J.; Nummenmaa, L.; Dukart, J.; Schilbach, L.; Lahnakoski, J. M.
10.1101/2025.02.04.636405 — neuroscience — Posted on 2025-07-15
294 Spatial probabilistic patterns of joint heat and water stress of chickpea in Australia
Lake, L. S.; Manson, J. B.; Severini, A. D.; Chauhan, Y.; Chenu, K. S.; Smith, M. R.; Sadras, V.
10.1101/2025.07.09.664009 — physiology — Posted on 2025-07-15
295 SH2scan: Mapping SH2 domain-ligand binding selectivity for inhibitors and degraders
Lira, L. M. G.; Wolfe-Demarco, J. K.; Clifford, A. M.; Le, T. D.; Khasawneh, G. M.; Kidane, M.; Nguyen, M.; Najera, J. A.; Pallares, G.; Servant, N. B.; Bernatchez, J. A.
10.1101/2025.07.09.663991 — pharmacology and toxicology — Posted on 2025-07-15
296 Tumor-initiating genetics and therapy drive divergent molecular evolution in IDH-mutant gliomas
Chowdhury, T.; Tesileanu, C. M. S.; Kocakavuk, E.; Johnson, K. C.; Lee, J.; Erson-Omay, Z.; Heo, C.; Aldape, K.; Amin, S. B.; Anderson, K. J.; Ashley, D. M.; Barnholtz-Sloan, J. S.; Brat, D. J.; Brodbelt, A. R.; Castro, A. V.; Claus, E. B.; Connelly, J. M.; Costello, J.; Datta, I.; Elliott, C.; Finocchiaro, G.; French, P. J.; Gan, H. K.; Garofano, L.; Ghospurkar, P. L.; Golebiewska, A.; Gundla, P. S.; Hermes, B.; Hong, C.; Hoogstrate, Y.; Horbinski, C.; Huse, J. T.; Iavarone, A.; Karadag, C.; Khasraw, M.; Kouwenhoven, M. C.; LaViolette, P. S.; Li, K.; Lowman, A.; McCortney, K.; Moon, H.-E.; Na
10.1101/2025.07.11.664189 — cancer biology — Posted on 2025-07-15
299 Expanding the DNA Motif Lexicon of the Transcriptional Regulatory Code
Fan, J.; Chaudhri, V. K.; Bisht, D.; Pease, N. A.; Hall, D. R.; Gerges, P.; Yi, V. F.; Kales, S.; Ho, C.-H.; Das, J.; Ray, J. P.; Tewhey, R.; Meyer, C. A.; Sahni, N.; Singh, H.
10.1101/2025.07.09.662874 — genomics — Posted on 2025-07-15
301 RIF1 orchestrates a multi-step restoration of post-replicative H3K9me3
Chen, N.; Bandau, S.; Ravindran Nair Pushkala Kumari, R.; Prevo, B.; Sasaki, T.; Web, S.; di Sanzo, S.; Shapira, D.; Völker-Albert, M.; Gilbert, D. M.; Alabert, C.; Buonomo, S. C. B.
10.1101/2025.07.14.664777 — cell biology — Posted on 2025-07-15
302 Dengue infection elicits skin tissue-resident and circulating CD8+ T-cells associated with protection from hospitalization.
Hamis, N. Z. B.; Ooi, J.; Cheung, K. W.; Chew, V. S. Y.; Gregorova, M.; Ong, E. Z.; Chan, K. R.; Thein, T. L.; Leo, Y.-S.; Lye, D. C. B.; Ooi, E. E.; Rivino, L.
10.1101/2025.07.11.664360 — immunology — Posted on 2025-07-15
304 Proximity to an SGC-DLPFC Individualized Functional Target and outcomes in large rTMS clinical trials for Treatment-Resistant Depression
Gregory, E.; Siddiqi, S. H.; Fox, M.; Blumberger, D. M.; Downar, J.; Daskalakis, Z. J.; Dunlop, K.; Vila-Rodriguez, F.
10.1101/2025.07.09.662866 — neuroscience — Posted on 2025-07-15
308 Exploiting an Epigenetic Resistance Mechanism to PI3 Kinase Inhibition in Leukemic Stem Cells
Glushakow-Smith, S. G.; Kaur, I.; Sidoli, S.; Hemmati, S.; Angeles, E.; Sinclair, T.; Chakraborty, S.; Battle, A.; Ames, K.; Narayanagari, S.-R.; Hyka, R.; Soto, M.; Tracy, M.; Vankudoth, J.; Kitamura, S.; Miles, L. A.; Steidl, U.; Shastri, A.; Verma, A.; Gritsman, K.
10.1101/2025.07.11.663968 — cancer biology — Posted on 2025-07-15
309 Metabolic Collapse in Pancreatic Cancer via Combined Inhibition of Lactate Export and Thioredoxin Reductase
Zygmunt, A.; Turlej, E.; Cichon, T.; Golec, M.; Zaremba-Czogalla, M.; Olczak, E.; Markowski, A.; Rakus, D.; Gubernator, J.
10.1101/2025.07.09.663998 — cancer biology — Posted on 2025-07-15
313 Architecture and Function of Holocentric CENP-A-Independent Kinetochores
Yu, C.; Sankaranarayanan, S. R.; Cornilleau, G.; Howes, A. C.; Azumaya, C.; Zilberleyb, I.; Brillantes, B.; Cheung, T. K.; Dec, L.; Loew, D.; Tran, P.; Rose, C. M.; Drinnenberg, I. A.; Ciferri, C.; Yatskevich, S.
10.1101/2025.07.14.664805 — cell biology — Posted on 2025-07-15
314 Easy and interactive taxonomic profiling with Metabuli App
Lee, S.; Kim, J.; Mirdita, M.; Gilchrist, C.; Steinegger, M.
10.1101/2025.03.10.642298 — bioinformatics — Posted on 2025-07-14
316 Transcriptomic response to different heme sources in Trypanosoma cruzi
Tevere, E.; Mediavilla, M. G.; Di Capua, C. B.; Merli, M. L.; Robello, C.; Berna, L.; Cricco, J. A.
10.1101/2025.07.14.664770 — biochemistry — Posted on 2025-07-14
317 Genome shuffling enables quantitative trait locus mapping in Bacillus subtilis
Vasileva, D. P.; Chhetri, H. B.; Hochanadel, L. H.; Streich, J. C.; Lagergren, J. H.; Lane, M. J.; Oksuz, E.; Carper, D. L.; Rubino, B.; Chitwood, S.; Schmitz, Z. D.; Klingeman, D. M.; Abraham, P. E.; Giannone, R. J.; Jacobson, D. A.; Michener, J. K.
10.1101/2025.07.14.664384 — microbiology — Posted on 2025-07-14
318 Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth
Letian, A.; Young, K.; Pi, A.; Gonzatti, M. B.; Volk, R. F.; Sharma, I.; Baker, C.; Benayoun, B. A.; Zaro, B. W.; Stratman, A. N.; Goldberg, E. L.
10.1101/2025.07.09.663961 — immunology — Posted on 2025-07-14
320 Cell-type-specific plasticity in synaptic, intrinsic, and sound response properties of deep-layer auditory cortical neurons after noise trauma
Zhao, Y.; Kouvaros, S.; Schneider, N. A.; Krall, R. F.; Lam, S.; Arnold, M. P.; Williamson, R. S.; Tzounopoulos, T.
10.1101/2025.07.09.663954 — neuroscience — Posted on 2025-07-14
322 AAV NRF2 Gene Therapy Preserves Retinal Structure and Function in Rodent Models of Oxidative Damage
Gardner, A.; Wang, S.; Daniels, A.; Li, D.; Wu, C.; Lin, L.; Hong, C.; Zhao, S.; Kruczek, K.; Weist, G.; Real, L. B.; Haurigot, V.; Born, R.; Cepko, C.
10.1101/2025.07.09.663952 — pharmacology and toxicology — Posted on 2025-07-14
326 Amino Acid Substitutions in the Na+/K+-ATPase May Contribute to Salinity Tolerance in Insects
Achi, P.; Iglesias, V.; Christensen, P.; Adrianza, R.; Bavier, L.; Pena, R.; McCarthy, C.; Baniya, A.; Collison, W. N.; Groen, S. C.; Dillman, A. R.
10.1101/2025.03.27.645771 — genetics — Posted on 2025-07-14
327 Evolutionary genomics reveals plant origins of acetic acid bacteria in fermented food
Cuesta-Mate, A.; Bret, T. P.; Duchene, D. A.; Oliverio, A. M.; Shik, J. Z.; Andersen, S. B.; Dunn, R. R.; Rodriguez, J. A.; Sinotte, V. M.
10.1101/2025.07.09.663944 — evolutionary biology — Posted on 2025-07-14
328 5' untranslated regions tune Toxoplasma translation
Peters, M. L.; Shukla, A.; Gotthold, Z. A.; McCormick, D. M.; Xiang, K.; Bartel, D. P.; Lourido, S.
10.1101/2025.07.14.664749 — molecular biology — Posted on 2025-07-14
329 SETD2 suppresses tumorigenesis in a KRASG12C-driven lung cancer model and its catalytic activity is regulated by histone acetylation
Mack, R.; Flores, N. M.; Fox, G. C.; Dong, H.; Cebeci, M.; Hausmann, S.; Chasan, T.; Dowen, J.; Strahl, B. D.; Mazur, P. K.; Gozani, O.
10.1101/2025.05.16.654513 — molecular biology — Posted on 2025-07-14
331 Increased proportion of growth-arrested bacilli in acidic pH adaptation promotes Mycobacterium tuberculosis treatment survival
Chung, E. S.; Johnson, W. C.; Kamkaew, M.; McNellis, M. E.; Smith, T. C.; Srinivasan, V.; Thuong, N. T. T. C.; Tan, S.; Aldridge, B. B.
10.1101/2025.07.14.664820 — microbiology — Posted on 2025-07-14
334 The energetic stress cytokine GDF15 is elevated in the context of chronic and acute psychosocial stress
Huang, Q.; Monzel, A. S.; Rausser, S.; Haahr, R.; Indik, C. E.; Savin, M. J.; Bobba-Alves, N.; Liu, C. C.; Devine, J.; Thompson, E.; Kelly, C.; Kurade, M. S.; Michelson, J.; Li, S.; Engelstad, K.; Lauriola, V.; Marsland, A. L.; Kaufman, B. A.; St-Onge, M.-P.; Sloan, R.; Juster, R.-P.; Gouspillou, G.; Hirano, M.; Picard, M.; Belsky, D. W.; Trumpff, C.
10.1101/2024.04.19.590241 — physiology — Posted on 2025-07-14
335 Constraints and adaptations in crocodyliform skull evolution
Srinivas, A.; Bright, J.; Cunningham, J.; Simionato Tavares, S. A.; Ricardi-Branco, F.; Carvalho, I. d. S.; Vidoi Iori, F.; Rayfield, E.
10.1101/2025.07.09.663933 — paleontology — Posted on 2025-07-14
336 EVOLUTIONARY ASSEMBLY OF CROWN REPTILE ANATOMY CLARIFIED BY LATE PALEOZOIC RELATIVES OF NEODIAPSIDA
Jenkins, X.; Benson, R. B. J.; Ford, D. P.; Browning, C.; Fernandez, V.; Dollman, K.; Gomes, T.; Griffiths, E.; Choiniere, J. N.; Peecook, B. R.
10.1101/2024.11.25.625221 — paleontology — Posted on 2025-07-14
337 Influential landmarks
Dujardin, J.-P.; Sriwichai, P.; Samung, Y.; Ruangsittichai, J.; Sumruayphol, S.; Dujardin, S.
10.1101/2025.07.14.664645 — bioinformatics — Posted on 2025-07-14
341 Mechanistic pathways of tick exposure risk in native and invaded plant communities
Hiatt, D.; Dillon, W.; Gardner, A.; Cabrera, S.; Dietze, M.; Allan, B.; Flory, S. L.
10.1101/2024.11.19.624319 — ecology — Posted on 2025-07-14
342 Multi-seasonal eDNA metabarcoding highlights a resurgence in fish diversity across a severely impacted estuarine ecosystem
Jackman, J. M.; Sales, N. G.; Benvenuto, C.; Drewitt, A.; Wolfenden, A.; Robins, P. E.; Coscia, I.; McDevitt, A. D.
10.1101/2025.07.09.663915 — ecology — Posted on 2025-07-14
345 Sertraline enhances bacterial control by improving the pharmacodynamic -pharmacokinetic properties of frontline TB drugs
Bisht, K.; Yadav, M.; Madan, M.; Biswas, L.; Pradhan, R.; Taliyan, R.; Singh, M.; Verma, A. K.; Rao, V. K.
10.1101/2025.07.13.664629 — microbiology — Posted on 2025-07-14
347 Early warning signals of emerging infectious diseases
Zhao, Q.; Moniz, N.; van Nes, E. H.; Scheffer, M.; Korotasz, A.; Barbera, C.; Rohr, J. R.
10.1101/2025.03.03.641350 — microbiology — Posted on 2025-07-14
350 Integrated Systems Vaccinology Reveals Distinct Metabolic Responses to SARS-CoV-2 Infection and DNA-Based Vaccines in Ferrets
Ahlen, G.; Ambikan, A.; Mikaeloff, F.; Rezene, S.; Yan, J.; Nikouyan, N.; Revanna, C. B.; Appelberg, S.; Mirazimi, A.; Sallberg, M.; Neogi, U.; Gupta, S.
10.1101/2025.07.11.664150 — immunology — Posted on 2025-07-14
352 The impact of a psychedelic drug on olfactory search behavior by mice
Welch, A. C.; Gonzales-Hess, N.; Tarvin, T. A.; Connor, J.; Smear, M. C.
10.1101/2025.07.09.663970 — neuroscience — Posted on 2025-07-14
356 MerQuaCo: a computational tool for quality control in image-based spatial transcriptomics
Martin, N. X.; Olsen, P.; Quon, J.; Campos, J.; Valera Cuevas, N. J.; Nagra, J.; VanNess, M.; Maltzer, Z.; Gelfand, E.; Oyama, A.; Gary, A.; Wang, Y.; Alaya, A.; Ruiz, A.; Reynoldson, C.; Bielstein, C.; Pom, C. A.; Huang, C.; Slaughterback, C.; Liang, E.; Alexander, J.; Ariza, J.; Malone, J.; Melchor, J.; Colbert, K.; Brouner, K.; Shulga, L.; Reding, M.; Latimer, P.; Sanchez, R.; Barta, S.; Egdorf, T.; Madigan, Z.; Pagan, C.; Close, J.; Long, B.; Kunst, M.; Lein, E.; Zeng, H.; McMillen, D. A.; Waters, J.
10.1101/2024.12.04.626766 — bioinformatics — Posted on 2025-07-14
359 Rational design of tertiary coordination sphere of a heme-based sensor for two-orders enhanced oxygen affinity
Damodaran, A. R.; Yee, E.; Khade, R. L.; Williams, M.; Apiche, E. A.; Wilson, R. H.; Hoey, E.; Larson, G.; Shi, K.; Aihara, H.; Zhang, Y.; Bhagi-Damodaran, A.
10.1101/2025.05.27.656425 — biochemistry — Posted on 2025-07-14
362 Identifying rare spontaneous mutations through wildtype E. coli population sequencing
Green, R.; Bawn, M.; Angus-Whiteoak, A.; Jago, M.; Whelan, F. J.; Lagator, M.; Hall, N.; Knight, C. G.; Krasovec, R.
10.1101/2025.07.08.663732 — evolutionary biology — Posted on 2025-07-14
363 Disentangling urbanisation, climate effects and their interaction on ornamental colourations
Sandmeyer, L.; Lopez-Idiaquez, D.; Fargevieille, A.; Giovannini, P.; Perret, S.; Del Rey, M.; Charmantier, A.; Doutrelant, C.; Gregoire, A.
10.1101/2025.02.19.639098 — ecology — Posted on 2025-07-14
364 Epigenetic remodeling via HDAC6 inhibition amplifies anti-tumoral immune responses in myeloid leukemia cells
Schliehe-Diecks, J.; Tu, J.-W.; Stachura, P.; Schaal, K.; Kemkes, M.; Vasileiou, E.; Ruechel, N.; Brandes, D.; Vogt, M.; Lenz, T.; Nair, A.; Scheu, S.; Dominguez, P.; Pastorczak, A.; Nebral, K.; Stuehler, K.; Fischer, U.; Pandyra, A.; Borkhardt, A.; Bhatia, S.
10.1101/2025.05.30.654805 — cell biology — Posted on 2025-07-14
365 A mutation in vesicular acetylcholine transporter increases tubulin acetylation compromising axonal transport
Kuo, C.-S.; Ruckmani, V. M.; Khawaja, M. S.; Wang, M.-C.; Bayansan, O.; Barmaver, S. N.; Bhan, P.; Wagner, O. I.
10.1101/2024.06.06.597842 — cell biology — Posted on 2025-07-14
366 Functional genomics reveals strain-specific genetic requirements conferring hypoxic growth in Mycobacterium intracellulare
Tateishi/Yoshitaka, Y.; Ozeki, Y.; Nishiyama, A.; Morishige, Y.; Minato, Y.; Baughn, A.; Matsumoto, S.
10.1101/2024.05.12.593797 — microbiology — Posted on 2025-07-14
367 TDP-43 pathology induces CD8+ T cell activation through cryptic epitope recognition
Chizari, S.; Zanovello, M.; Kong, S.; Saigal, V.; Brown, A.-L.; Turchetti, V.; Zampedri, L.; Skorupinska, I.; Minicuci, G. M.; Paron, F.; Tonin, P.; Marchetto, G.; Li, Z.; Colon-Mercado, J.; Dattilo, D.; Barattucci, S.; Gatt, A.; Qi, Y.; Hanna, M.; Ward, M.; Petrucelli, L.; Romano, M.; Vattemi, G.; Buratti, E.; Malaspina, A.; Merve, A.; Machado, P.; Soraru, G.; Fratta, P.; Jiang, N.
10.1101/2025.06.22.660773 — immunology — Posted on 2025-07-14
368 The Lab Streaming Layer for Synchronized Multimodal Recording
Kothe, C.; Shirazi, S. Y.; Stenner, T.; Medine, D.; Boulay, C.; Grivich, M. I.; Artoni, F.; Mullen, T.; Delorme, A.; Makeig, S.
10.1101/2024.02.13.580071 — neuroscience — Posted on 2025-07-14
369 Improved transfection methods of primary cultured astrocytes for observation of cytoskeletal structures
IKOMA, C.; INOUE, K.; KASAI, K.; TSUKUDA, S.; TAMURA, A.; NAKATA, S.; IWATA, Y.; TAMAGAWA, T.; NAKAYAMA, A.; TAKANO, K.; SHIGETOMI, E.; KOIZUMI, S.; NAKAGAWA, H.; TERASAKI, A. G.
10.1101/2025.01.27.635031 — neuroscience — Posted on 2025-07-14
371 Mechanical stress and caveolin-1 control the release of extracellular vesicles with increased tumorigenic properties
Saquel, C.; Bochler, L.; MacDonald, E.; Gracia, C.; Viaris de Lesegno, C.; Verweij, F.; Urena-Martin, C.; Masson, V.; Loew, D.; Raposo, G.; GOETZ, J. G.; Hyenne, V.; Lamaze, C.
10.1101/2024.09.05.611225 — cancer biology — Posted on 2025-07-14
373 The blobulator: a toolkit for identification and visual exploration of hydrophobic modularity in protein sequences
Pitman, C.; Santiago-McRae, E.; Lohia, R.; Lamb, R.; Bassi, K.; Riggs, L.; Joseph, T. T.; Hansen, M. E. B.; Brannigan, G.
10.1101/2024.01.15.575761 — bioinformatics — Posted on 2025-07-14
374 CREB drives acinar cells to ductal reprogramming and promotes pancreatic cancer progression in preclinical models of alcoholic pancreatitis
Srinivasan, S.; Mehra, S.; Jinka, S.; Bianchi, A.; Singh, S.; Dosch, A. R.; Amirian, H.; Krishnamoorthy, V.; Silva, I. D. C.; Patel, M.; Box, E. W.; Garrido, V.; Totiger, T. M.; Zhou, Z.; Ban, Y.; Datta, J.; VanSaun, M.; Merchant, N.; Nagathihalli, N.
10.1101/2024.01.05.574376 — cancer biology — Posted on 2025-07-14
379 Multi-omics analysis highlights the link of aging-related cognitive decline with systemic inflammation and alterations of tissue-maintenance
Flor, S.; Dost, T.; Haase, M.; Simon, R.; Ederer, S.; Kadibalban, S.; Taubenheim, J.; Olecka, M.; Walker, A.; Zimmermann, J.; Marinos, G.; Franzenburg, S.; Schmitt-Kopplin, P.; Baines, J.; Riege, K.; Hoffmann, S.; Best, L.; Frahm, C.; Kaleta, C.
10.1101/2025.07.13.662751 — systems biology — Posted on 2025-07-14
382 Granulin+ macrophages promote lineage plasticity in prostate cancer through paracrine signaling loops
Zhu, Z.; Zhang, M.; Song, Y.; Jiang, W.; Cao, F.; Yao, Y.; Yu, X.; Zhao, H.; Baiyin, H.; Chang, D.; Wu, D.; Zhao, X.; Wu, G.; Li, K.; Mao, F.
10.1101/2025.07.09.663835 — cancer biology — Posted on 2025-07-14
385 A 3D in vitro model of the human hepatobiliary junction
Westerfield, A. D.; Grzelak, K. A.; Katsuyama, K.; Kumar, V.; Miller, B. M.; Yun, J.; Kirkpatrick, J.; Mankus, D.; Bisher, M. E.; Lytton-Jean, A. K.; Jiang, Z. G.; Lee, D. D.; Chen, C. S.; Bhatia, S. N.
10.1101/2025.07.11.664464 — bioengineering — Posted on 2025-07-14
387 Biohybrid tendons enhance the power-to-weight ratio and modularity of muscle-powered robots
Castro, N.; Bawa, M.; Aymon, B.; Wu, S.; Marschner, A.; Kohli, S.; Rosado, L.; Culpepper, M.; Zhao, X.; Raman, R.
10.1101/2025.07.10.664167 — bioengineering — Posted on 2025-07-14
389 Evaluating long-term stool preservation methods for maximizing the recovery of viable human fecal microbiota
Teo, Y.; Lavrinienko, A.; Albertos Torres, D.; Asare, P. T.; Ruder, A.; Dominguez-Bello, M. G.; Adrian, E.; Bokulich, N.; Vonaesch, P.
10.1101/2025.07.11.664436 — microbiology — Posted on 2025-07-14
390 A nuclear CobW/WW-domain factor represses the CO2-concentrating mechanism in the green alga Chlamydomonas reinhardtii
Shimamura, D.; Yasuda, J.; Yamahara, Y.; Nakano, H.; Ozawa, S.-I.; Tokutsu, R.; Yamagami, A.; Matsushita, T.; Takahashi, Y.; Nakano, T.; Fukuzawa, H.; Yamano, T.
10.1101/2025.07.09.663896 — plant biology — Posted on 2025-07-14
392 Immune cells regulate circulating adipocyte extracellular vesicle levels in response to metabolic shifts
Tiash, S.; Russo, M.; Pai, Y.-L.; Jia, W.; Field, R. L.; Pietka, T.; Abumrad, N. A.; Smith, G. I.; Klein, S.; Brestoff, J. R.; Crewe, C.
10.1101/2025.07.11.664236 — physiology — Posted on 2025-07-14
398 Aerosolized ApoA1 Nanoparticles Synthesized by Microfluidics Cross the Lung Barrier and Modulate Inflammation
Apalama, M. L.; Givran, L.; Navarette, B.; Bringart, M.; Giraud, P.; Rondeau, P.; Meilhac, O.; Allard, B.
10.1101/2025.07.09.663869 — bioengineering — Posted on 2025-07-14
399 Orthogonal chemical genomics approaches reveal genomic targets for increasing anaerobic chemical tolerance in Zymomonas mobilis
Eckmann, J.; Enright, A. L.; Davies, M.; Whelan, E.; Myers, K. S.; Robinson, M. L.; Banta, A. B.; Lal, P. B.; Coon, J. J.; Sato, T. K.; Kiley, P. J.; Peters, J. M.
10.1101/2025.07.09.663894 — genomics — Posted on 2025-07-14
400 Telomere-to-telomere assemblies reveal complex adaptive variation of 3-ketoacyl-CoA-synthases in Populus trichocarpa likely driven by helitrons
Kainer, D.; Martin, S.; Hopp, D.; Mosher, S.; Tschaplinski, T. J.; Hyatt, P. D.; Martin, M. Z.; Leboldus, J. M.; Sondreli, K. L.; Busby, P. E.; Shu, M.; Barry, K.; Schmutz, J.; Furches, A.; Zhao, N.; Jacobson, D.; Chen, J.-G.; Pavicic, M.; Ranjan, P.; Muchero, W.; Tuskan, G. A.; Garvin, M. R.
10.1101/2025.07.10.664019 — genomics — Posted on 2025-07-14
402 Implications of future change scenarios for mosquito-borne disease transmission in the Netherlands
de Wit, M. M.; Dellar, M.; Geerling, G.; Boelee, E.; De Jong, M. C. M.; ten Bosch, Q.
10.1101/2025.07.09.663836 — ecology — Posted on 2025-07-14
403 Macropinocytosis inhibition attenuates pro-fibrotic responses in lung fibroblasts and pulmonary fibrosis
Rosas, I.; McDowell-Sanchez, A.; Sanchez, S.; Cala-Garcia, J.; Cohen, A. W.; Echartea, M.; Ochsner, S. A.; Kraushaar, D.; Celada, L. J.; Sun, D.; Polverino, F.; Coarfa, C.; McKenna, N.; Tsoyi, K.
10.1101/2025.07.09.663937 — molecular biology — Posted on 2025-07-14
404 The mevalonate pathway of isoprenoid biosynthesis supports metabolic flexibility in Mycobacterium marinum
Qabar, C.; Baidoo, E. E.; Akyuz Turumtay, E.; Qayum, T.; Keasling, J. D.; Madigan, C.; Portnoy, D. A.; Cox, J. S.
10.1101/2025.07.11.664281 — microbiology — Posted on 2025-07-14
406 IL-33 promotes transcriptional and metabolic adaptations of tissue-resident Th2 cells
Kania, A. K.; Sanin, D. E.; Gu, X.; Kokosinski, E.; Smith, A.; Pearce, E. L.; Pearce, E. J.
10.1101/2025.07.09.663905 — immunology — Posted on 2025-07-14
407 Foveated metamers of the early visual system
Broderick, W. F.; Rufo, G.; Winawer, J.; Simoncelli, E.
10.1101/2023.05.18.541306 — neuroscience — Posted on 2025-07-14
408 A bistable circuit regulates miRNA-155 levels in human macrophage inflammatory transitions
Mora-Rodriguez, R. M.; Guevara-Coto, J.; Acon, M. S.; Torres-Calvo, J.; Oviedo, G.; Regnier-Vigouroux, A.; Geiss, C.
10.1101/2025.07.09.663909 — systems biology — Posted on 2025-07-14
409 Fragment-Guided New Therapeutic Molecule Discovery and Mapping of Clinically Relevant Interactomes
Kanapeckaite, A.; Okuyan, S.; Wagg, D. J.; Koster, J.; Jancoriene, L.; Sakalauskaite, I.; Brasiuniene, B.; Townsend-Nicholson, A.
10.1101/2025.07.09.663848 — pharmacology and toxicology — Posted on 2025-07-14
414 Learned Geometry, Predicted Binding: Structurally-BasedPrediction of Peptide:MHC Binding Using AlphaFold 3 EnablesCD4 T Cell Epitope Prediction
Lahouel, K.; Mulazimuglu, M.; Soria-Bustos, J.; Bates, K.; Kelley, E. J.; Woods, L. J.; Upadhyaya, K. M.; Acevedo, G. R.; Penisson, S.; Munini, M.; Variani, E.; Feeney, M. E.; Altin, J.; Tomasetti, C.
10.1101/2025.07.10.664203 — bioinformatics — Posted on 2025-07-14
418 Lysine acetylation plays a role in RNA binding protein-regulated alternative pre-mRNA splicing.
Keppetipola, N. M.; Nunez, C.; Salgado, G.; Tran, U.; Horani, A.; Dreyer, S.; Luchko, T.
10.1101/2025.07.11.664476 — biochemistry — Posted on 2025-07-14
419 Comparing analytical protocols for identifying causes of population changes
Malinowska, K.; Wawrzynowicz, M.; Markowska, K.; Chodkiewicz, T.; Butler, S.; Kuczynski, L.
10.1101/2025.05.17.654658 — ecology — Posted on 2025-07-14
426 A multiplex extracellular interactome screening method employing high-avidity nanoparticles
Anaya, M.; Wang, M. L.; Gonzalez, E.; Lam, A. W.; Vasnarungruengkul, P.; Vielmetter, J.; Wojtowicz, W. M.; Zinn, K.
10.1101/2025.07.09.663943 — molecular biology — Posted on 2025-07-14
427 Pharmacokinetics and In vivo Efficacy of Epetraborole against Burkholderia pseudomallei
Cummings, J. E.; Flores, D.; Guglielmi, V. E.; Dooley, G.; Alley, M. R. K.; Slayden, R. A.
10.1101/2025.07.10.664055 — microbiology — Posted on 2025-07-14
428 B cell/adipocyte crosstalk drives pro-fibrotic macrophage migration and polarisation in Crohn`s disease-associated, inflamed adipose tissue
Goess, M. C.; Heinze, J. M.; Hofmann, J. N.; Buck, A.; Gadjalova, I.; Weber, M.-C.; Ring, S.; Buescher, J. M.; Villa, M.; Neumann, P.-A.; Ruland, J.; Keppler, S. J.
10.1101/2025.07.11.664132 — immunology — Posted on 2025-07-14
430 Dynamic extracellular interactions with AMPA receptors
Merrion, H. G.; Barber, C. N.; Renuse, S. S.; Cutler, J.; Kreimer, S.; Bygrave, A. M.; Meyers, D. J.; Hale, W. D.; Pandey, A.; Huganir, R. L.
10.1101/2025.07.11.664166 — neuroscience — Posted on 2025-07-14
433 A comparison of adiponectin-deficient mice reveals the fundamental role of intracellular adiponectin
Onodera, T.; Kim, D.-S.; Wang, M.-Y.; Virostek, M.; Chen, S.; Kipp, Z. A.; Bates, E. A.; Li, Y.; Crewe, C.; Li, C.; Sun, X.-N.; Zhang, Q.; Shao, M.; Shin, J.; Kusminski, C. M.; Gordillo, R.; Gupta, R. K.; Hinds, T. D.; Shimomura, I.; Scherer, P. E.
10.1101/2025.07.12.664095 — physiology — Posted on 2025-07-14
434 SOX2 is a dispensable modulator of NUT carcinoma oncogenesis in mouse
Gu, B.; Luo, C.; Zheng, D.; Elnegiry, A.; Bhatara, S.; Mias, G. I.; Tsoi, M. F.; Yu, J.
10.1101/2025.07.09.664010 — cancer biology — Posted on 2025-07-14
435 Optimized large-scale longitudinal biorepository of gastroesophageal adenocarcinoma patient-derived organoids: High-fidelity models for personalized treatment to overcome resistance.
Kong, M.; Pal, S.; Wang, S.; Berube, J.; Ma, R.; Yan, Y.; Zeng, W.; Bourdeau, F.; Giannias, B.; Zhao, H.; Osman, N.; Nevo, Y.; Tai, K.; Kuasne, H.; Tankel, J.; Everisto, G.; Fiset, P.; Su, X.; Bailey, S.; Park, M.; Bertos, N.; Sangwan, V.; Ferri, L.
10.1101/2025.07.09.663874 — cancer biology — Posted on 2025-07-14
438 A Hierarchical Robust Linear Model for Cryo-EM Map Analysis
Tu, I.-P.; Zheng, S.-C.; Lien, Y.-H.; Lin, S. H.; Lin, P.-C.; Chang, W.-H.
10.1101/2025.07.10.664269 — bioinformatics — Posted on 2025-07-14
439 Protein Abundance Inference via Expectation Maximization in Fluorosequencing
Kipen, J.; Smith, M. B.; Blom, T.; Zhou, S. B.; Marcotte, E. M.; Jalden, J.
10.1101/2025.07.10.664057 — bioinformatics — Posted on 2025-07-14
446 Conformational asymmetry of replicated human chromosomes
Corsi, F.; Kolesnikova, S.; Steinacker, T. L.; Takacs, Z.; Batty, P.; Mitter, M.; Gerlich, D. W.; Goloborodko, A.
10.1101/2025.07.09.663929 — molecular biology — Posted on 2025-07-14
450 Neurophysiological correlates of passive movements are speed- and type-dependent
Veldman, M. P.; Kwant, J. Z.; Lommerse, J.; Feenstra, M.; Lamoth, C. J. C.; Volkers, A. H. M.; Drenth, H.; Zuidema, S.; Bautmans, I.; Hobbelen, H.
10.1101/2025.07.09.663910 — neuroscience — Posted on 2025-07-14
453 Deep mapping of the endomembrane system of cerebellar Purkinje neurons
Haberl, M. G.; Viana da Silva, S.; Phan, S.; Bushong, E.; Deerinck, T.; Ellisman, M. H.
10.1101/2025.07.08.663701 — neuroscience — Posted on 2025-07-14
456 The Magnaporthe oryzae MAX effector AVR-Pia binds a novel group of rice HMA domain-containing proteins
Maidment, J. H.; Saile, S. C.; Bocquet, A.; Thivolle, C.; Bourcet, L.; Planel, L.-F.; Gelin, M.; Kroj, T.; Padilla, A.; De Guillen, K.; Cesari, S.
10.1101/2025.07.11.664054 — plant biology — Posted on 2025-07-14
458 Heat Stress and Soil Microbial Disturbance Influence Soybean Root Metabolite, Microbiome Profiles, and Nodulation
Elango, D.; Van der Laan, L.; Gholizadeh, S.; Premarathne, M. D. G. P.; Dutter, C. R.; DePew, C.; McDaniel, M.; Singh, A. K.
10.1101/2025.07.13.664636 — plant biology — Posted on 2025-07-14
459 Hypoxia-Induced Metabolic Reprogramming and Markings of Cell Fate in Concentric Arterial Hypertrophy
Ferreira de Almeida, L.; Smith, J. P.; Yamaguchi, M.; Medrano, S.; Martini, A.; Matsuoka, D.; Juskiewicz, Z. J.; Isakson, B. E.; Yamaguchi, H.; Trevisan-Silva, D.; Wagamon, T.; Sequeira-Lopez, M. L. S.; Gomez, R. A.
10.1101/2025.07.09.663881 — physiology — Posted on 2025-07-14
461 Activating RET Mutations Promotes Osteoblastic Bone Metastases in Medullary Thyroid Cancer
Yarmand, R. B.; Pagnotti, G. M.; Kidd, J. L.; Ramirez, D. A.; Trivedi, T.; Guerra, L.; Wang, Z.; Cruz, L. M.; Moehle, J. M.; Jebaraj, Y. S.; Wan, X.; Song, J. H.; Bassett, R.; Lin, S.-H.; Hu, M. I.; Sherman, S. I.; Hofmann, M.-C.; Guise, T.
10.1101/2025.07.09.663851 — cancer biology — Posted on 2025-07-14
462 Decomposing Predictive Information in Social Dynamics
Kawano, A.; O'Shaughnessy, L.; Neiman, R.; Deligkaris, K.; Rodriguez, L. C.; Masai, I.; Stephens, G. J.
10.1101/2025.05.16.654393 — biophysics — Posted on 2025-07-14
463 smDeepFLUOR: Single-Molecule Deep Learning Fluorescence Classification
Lee, J.; Kim, B.; Bu, G.; Tehseen, M.; Raducanu, V.-S.; Hamdan, S. M.; Lee, J.-B.
10.1101/2025.07.09.663809 — biophysics — Posted on 2025-07-14
467 Systematic cross-study assessment of RNA-Seq experimental workflows for plasma cell-free transcriptome profiling
Tuni, C.; Asole, G.; Monteagudo-Mesas, P.; Rusu, E. C.; Cabus, L.; Gonzalez, L.; Sanchez, L.; Neto, B.; Sanders, P.; Weber, M.; Lagarde, J.
10.1101/2025.07.10.664092 — bioinformatics — Posted on 2025-07-14
468 Mammal placental phenotypes are predictable from microRNA repertoires.
Fenn, J.; Edge, J. C.; Ovchinnikov, V.; Amelkina, O.; Sinclair, M.; De Bem, T. H. C.; Bridi, A.; Malo-Estepa, I.; Tinning, H.; Gonella-Diaza, A.; Perecin, F.; da Silveira, J. C.; Pugliesi, G.; Meirelles, F. V.; Butt, Z.; Fromm, B.; McInerney, J. O.; Forde, N.; O'Connell, M. J.
10.1101/2025.06.27.660101 — genomics — Posted on 2025-07-14
472 Multiannual environmental forcing shapes breeding phenology and success in a subantarctic seabird
Bardon, G.; Barracho, T.; Durant, J.; Lecomte, N.; Le Maho, Y.; Stenseth, N. C.; Cristofari, R.; Le Bohec, C.
10.1101/2025.07.09.663721 — ecology — Posted on 2025-07-14
475 Determining the core bacterial and fungal genera in table olive fermentations.
Ricciardi, A.; Lopez, F. N. A.; Giavalisco, M.; Pietrafesa, R.; Parente, E.
10.1101/2025.03.16.643505 — microbiology — Posted on 2025-07-14
480 IsoDGR-Induced Endothelial Cytoskeletal Disruption Drives Age-Related Blood-Brain Barrier Breakdown
Patel, R.; Kalailingam, P.; Ngan, S. C.; Iyappan, R.; Nwaeze, J.; D'Amore, B.; Katoueezadeh, M.; Thinakaran, Y.; Laein, M. H.; Faught, B. E.; MacPherson, R. E.; Tsiani, E. L.; Klentrou, P.; De Kleijn, D.; Kalaria, R. N.; McCarthy, N. E.; Sze, S. K.
10.1101/2025.07.08.663800 — neuroscience — Posted on 2025-07-14
481 Host-adapted enzymatic deconstruction of acetylated xylan enables mutualistic colonization of monocot roots
Brands, M.; Ramirez, V.; Armbruster, L.; Eichfeld, R.; Endeshaw, A. B.; Pauly, M.; Zuccaro, A.
10.1101/2025.07.11.663926 — plant biology — Posted on 2025-07-14
483 A plant pathogen effector blocks stepwise assembly of a helper NLR resistosome
Seager, B. A.; Harant, A.; Contreras, M. P.; Hou, L.-Y.; Wu, C.-H.; Kamoun, S.; Madhuprakash, J.
10.1101/2025.07.14.664264 — plant biology — Posted on 2025-07-14
484 Targeting the 3D genome by anthracyclines for chemotherapeutic effects
Tan, M.; Sun, S.; Liu, Y.; Perreault, A. A.; Phanstiel, D. H.; Dou, L.; Pang, B.
10.1101/2024.10.15.614434 — cancer biology — Posted on 2025-07-14
487 Shifting Beyond Classical Drug Synergy in Combinatorial Therapy through Solubility Alterations
Gholizadeh, E.; Zangene, E.; Vadadokhau, U.; Ritz, D.; Soliymani, R.; Miettinen, J. J.; Baumann, M.; Wilhelm, M.; Heckman, C. A.; Saei, A. A.; Jafari, M.
10.1101/2024.11.08.618644 — biochemistry — Posted on 2025-07-14
494 Stem cells actively suppress regenerative plasticity in human colon
Hageman, J. H.; Yalcin, D.; Buissant des Amorie, J. R.; Brunner, S. R.; Kluiver, T. A.; Balwierz, A.; Langner, F. L.; Puschhof, M. C.; Bollen, Y.; Margaritis, T.; Snippert, H. J. G.
10.1101/2025.07.13.664589 — cell biology — Posted on 2025-07-14
496 Multimodal Validation of the Existence of Transitional Cerebellar Progenitors in the Human Fetal Cerebellum
Luo, Z.; Xia, M.; Zhang, F.; Xin, D.; Rao, R.; Kiang, K.; Berry, K.; Xiong, Y.; Liu, H.; Lin, Y.; Hu, M.; Xin, M.; Ma, J.; Li, H.; Taylor, M. D.; Zhou, W.; Lu, Q. R.
10.1101/2025.06.01.657310 — developmental biology — Posted on 2025-07-14
497 Salmonella Effector SteE Reprogrammes the Macrophage Regulatory Network to Drive Specific Hyperactivation of STAT3 Target Genes
Diaz-del-Olmo, I.; O'Sullivan, P. A.; Shizukuishi, S.; Stypulkowska, A.; Panagi, I.; Grzymajlo, K.; Ogawa, M.; Hill, P. W. S.; Thurston, T. L. M.
10.1101/2025.07.11.664171 — cell biology — Posted on 2025-07-14
499 Thioredoxin-1 inhibits granulosa cell ferroptosis to rescue ovarian aging through mitophagy-dependent activation of BNIP3L
Yang, W.; Zhang, X.; Xu, R.; Huang, Z.; Ma, Y.; Yang, J.; Lin, Z.; Ma, G.; Xu, J.; Qiao, Y.; Xiao, Z.; Cao, J.; Li, S.; Zhang, X.; Hutchins, A.; Tong, G.
10.1101/2025.07.12.664497 — cell biology — Posted on 2025-07-14
500 A Human Angelman Syndrome Class II Pluripotent Stem Cell line with Fluorescent Paternal UBE3A Reporter
Kelkar, G. R.; Stuppy, S. R.; Sen, D.; Yagci, Z. B.; Han, L.; Land, L.; Hartman, J. K.; Keung, A. J.
10.1101/2025.07.12.664539 — cell biology — Posted on 2025-07-14
501 Linguistic coupling between neural systems for speech production and comprehension during real-time dyadic conversations
Zada, Z.; Nastase, S. A.; Speer, S.; Mwilambwe-Tshilobo, L.; Tsoi, L.; Burns, S.; Falk, E.; Hasson, U.; Tamir, D.
10.1101/2025.02.14.638276 — neuroscience — Posted on 2025-07-14
502 State-specific Peptide Design Targeting G Protein-coupled Receptors
Xue, Y.; Wang, H.; Li, J.; Hu, J.; Chen, Z.; Zheng, Z.; Liu, L.; Zhu, K.; He, J.; Gong, H.; Li, X.; Zhang, X.; Fang, X.
10.1101/2024.11.27.625792 — bioinformatics — Posted on 2025-07-14
503 Nucleotide dependency analysis of DNA language models reveals genomic functional elements
Tomaz da Silva, P.; Karollus, A.; Hingerl, J.; Galindez, G.; Wagner, N.; Hernandez-Alias, X.; Incarnato, D.; Gagneur, J.
10.1101/2024.07.27.605418 — genomics — Posted on 2025-07-13
504 CROPseq-multi: a universal solution for multiplexed perturbation in high-content pooled CRISPR screens
Walton, R. T.; Qin, Y.; Kirby, B.; Andrews, J. O.; Taipale, M.; Kang, B.; Blainey, P. C.
10.1101/2024.03.17.585235 — genomics — Posted on 2025-07-13
510 Quantifying the varying harvest of fermentation products from the human gut microbiota
Arnoldini, M.; Sharma, R.; Moresi, C.; Chure, G.; Chabbey, J.; Slack, E.; Cremer, J.
10.1101/2024.01.05.573977 — microbiology — Posted on 2025-07-13
515 A novel motif in calcimembrin/C16orf74 dictates multimeric dephosphorylation by calcineurin
Bradburn, D. A.; Reis, J. C.; Moreno, R. Y.; Qayyum, S.; Viennet, T.; Arthanari, H.; Cyert, M. S.
10.1101/2024.05.12.593783 — biochemistry — Posted on 2025-07-13
517 Surface-enhanced Raman spectroscopy on the membranes for antimicrobial resistance testing
Mushenkov, V.; Andreev, E.; Nechaev, A.; Poddubikov, A.; Kukushkin, V.; Zavyalova, E.
10.1101/2025.07.12.664554 — microbiology — Posted on 2025-07-13
520 Uncovering bacterial pseudaminylation with pan-specific antibody tools
Karlic, K. I.; Tang, A. H.; Madiedo Soler, N.; Corcilius, L.; Lehmann, C.; Debowski, A.; Dale, A. L.; Zavan, L.; Cielesh, M.; Adewale, A. P.; Moulton, K. D.; Li, L.; Guan, C.; Kaparakis-Liaskos, M.; Howden, B. P.; Wei, R.; Li, X.; Dube, D. H.; Cordwell, S. J.; Larance, M.; Stubbs, K. A.; Carter, G. P.; Scott, N.; Goddard-Borger, E. D.; Payne, R. J.
10.1101/2025.07.13.664564 — biochemistry — Posted on 2025-07-13
521 Production and evaluation of fluorophore-doped polymer substrates to screen for plastic-degrading enzymes
Stepnov, A. A.; Norton-Baker, B.; Lopez-Tavera, E.; Chowreddy, R. R.; Eijsink, V. G. H.; Beckham, G. T.; Vaaje-Kolstad, G.
10.1101/2025.07.13.664576 — biochemistry — Posted on 2025-07-13
522 Amyloid-beta fibrils induce calcium phosphate crystallization via catalysis of ATP hydrolysis
mambram kunnath, s.; arad, e.; slavsky, e.; friedlander, l.; rapaport, h.; jelinek, r.
10.1101/2025.07.12.664505 — biochemistry — Posted on 2025-07-13
524 Co-circulation of distinct high pathogenicity avian influenza virus (HPAIV) subtypes in a mass mortality event in wild seabirds and co-location with dead seals
Falchieri, M.; Bentley, E.; Coombes, H. A.; Mollett, B. C.; Terrey, J.; Holland, S.; Stubbings, E.; McGinn, N.; Cooper, J.; Ahmad, S.; Lewis, J.; Clifton, B.; Collison, N.; Aegerter, J.; Venkatesh, D.; Russell, D.; James, J.; Reid, S. M.; Banyard, A. C.
10.1101/2025.07.11.664278 — genetics — Posted on 2025-07-13
525 Coexistence of Photosynthetic Marine Microorganisms, Viruses, and Grazers: Toward Integration in Ocean Ecosystem Models
Fremont, P.; Beckett, S. J.; Demory, D.; Carr, E.; Follett, C. L.; Talmy, D.; Dutkiewicz, S.; Weitz, J. S.
10.1101/2025.07.11.664470 — ecology — Posted on 2025-07-13
526 Cortical organoids reveal human-specific roles of METTL5 in neurodevelopment via regulation of CHCHD2
Turkalj, E. M.; Kuljanishvili, M.; Kang, G.; Liu, I.; Ghent, C.; Waltier Soriano, C.; Keyhanvar, N.; Brody, D.; Oldham, M.; Vissers, C.
10.1101/2025.07.13.664555 — molecular biology — Posted on 2025-07-13
533 An Automated End-to-End Workflow for Production of Secreted Proteins in Transfected Mammalian Cells
Vasnarungruengkul, P.; Anaya, M. A.; Lam, A. W.; Gonzalez, E.; Zhang, A.; Wang, M. L.; Wojtowicz, W.; Zinn, K.; Vielmetter, J.
10.1101/2025.07.13.664612 — biochemistry — Posted on 2025-07-13
534 KIF5A downregulation in spinal muscular atrophy links axonal regeneration defects with ALS
Akiyama, T.; Zeng, Y.; Guo, C.; Gautier, O.; Koepke, L. S.; Bombosch, J.; Sianto, O.; Ross, J. P.; Hoang, P. T.; Zhao, L. Y.; Spencer, C.; Monje, M.; Day, J. W.; Gitler, A. D.
10.1101/2025.07.11.664426 — neuroscience — Posted on 2025-07-13
535 Impact of sex and glial tau expression on heat shock protein induction in a Drosophila model of tauopathy
Whitmore, M.; Coughlin, M.; Kahlson, M.; Alvarez, J.; Zebrowski, L.; Colodner, K. J.; McMenimen, K. A.
10.1101/2025.07.10.664197 — neuroscience — Posted on 2025-07-13
536 High-Throughput Tracking of Freely Moving Drosophila Reveals Variations in Aggression and Courtship Behaviors
Sengupta, S.; Chen, Z.; Efromson, J.; Begue, A.; Harfouche, M.; Adegbesan, A. S.; Urquhart, A. E.; Chan, Y. B.; Yang, S.; Henry, S. A.; Palavicino-Maggio, C. B.
10.1101/2025.07.10.663947 — neuroscience — Posted on 2025-07-13
540 Single-cell analysis of a salmonid immune system (brown trout Salmo trutta) reveals evolutionary divergence and hatchery-induced transcriptional reprogramming
Ord, J.; Martinez, H. S.; Solbakken, M. H.; Berezenko, A.; Oberhaensli, S.; Talker, S. C.; Schmidt-Posthaus, H.; Adrian-Kalchhauser, I.
10.1101/2025.05.04.652114 — immunology — Posted on 2025-07-13
542 Long term trend and short-term dynamics of a willow grouse population
Willebrand, T.; Hornell-Willebrand, M.; Brittas, R.; Kleiven, E.
10.1101/2023.05.03.539219 — ecology — Posted on 2025-07-13
543 Cell atlas of the developing human meninges reveals a dura origin of meningioma
Vinsland, E.; Marco Salas, S.; Kapustova, I.; Hu, L.; Webb, S.; Li, X.; He, X.; Nilsson, M.; Haniffa, M.; Barker, R. A.; Persson, O.; Raleigh, D. R.; Sundström, E.; Lönnerberg, P.; Linnarsson, S.
10.1101/2025.07.08.663122 — developmental biology — Posted on 2025-07-13
544 Identifying regulators of associative learning using a protein-labelling approach in C. elegans
Rahmani, A.; McMillen, A.; Allen, E.; Ansaar, R.; Green, R.; Johnson, M. E.; Poljak, A.; Chew, Y. L.
10.1101/2024.02.19.580416 — neuroscience — Posted on 2025-07-13
545 Non-lytic replicating viral delivery of an IL15 superagonist enhances antitumor immunity and extends survival in glioblastoma
Haddad, A. F.; Saha, A.; Spatz, J.; Collins, S.; Lovalvo, I.; Gill, S.; Montoya, M. L.; Shukla, P.; Hong, J.; Wang, E.; Chuntova, P.; Lad, M.; Osorio, R.; Chen, J.-S.; Jain, S.; Chalif, E.; Kasahara, N.; Aghi, M. K.
10.1101/2024.10.14.618095 — cancer biology — Posted on 2025-07-13
546 Proteomic Analysis of Breast Cancer Subtypes Identifies Stromal Protein Profiles that Contribute to Aggressive Malignant Behavior
Burton, J. B.; Gascard, P.; Pan, D.; Bons, J.; Bai, R.; Chen-Tanyolac, C.; Caruso, J. A.; Hunter, C.; Schilling, B.; Tlsty, T. D.
10.1101/2025.01.21.634187 — cancer biology — Posted on 2025-07-13
547 Idiosyncratic and generic single nuclei and spatial transcriptional patterns in papillary and anaplastic thyroid cancers
Tourneur, A.; Rodrigues Vitoria, J.; Saiselet, M.; Craciun, L.; Larsimont, D.; Lefort, A.; Libert, F.; Maenhaut, C.; Costagliola, S.; Tarabichi, M.; Romitti, M.; Detours, V.
10.1101/2024.02.15.580495 — cancer biology — Posted on 2025-07-12
551 Targeting NEDD9-SH3 with a Covalent Peptide Controls Endothelial Phenotype
Samokhin, A. O.; Seo, H.-S.; Leed, A.; Hajiian, B.; Bird, G. H.; McKinney, D. C.; Saha, P.; Daum, J.; Moroco, J. A.; Yehl, J.; Kornfilt, D.; Sczceniowski, A.; Petrunak, E.; Horner, S.; Kaylin, J. H.; Leymarie, N.; Kaushik, V. K.; Walensky, L. D.; Cole, P. A.; Oldham, W. M.; Steinhauser, M. L.; Dhe-Paganon, S.; Maron, B. A.
10.1101/2025.07.10.663547 — molecular biology — Posted on 2025-07-12
552 3D-super-enhancers are condensate-associated cis-regulatory communities
Lv, J.; Maher, K. A.; Dong, L.; Valentine, V.; Veluchamy, A.; Tian, L.; Kim, Y.; Ju, B.; Valentine, M.; Easton, J.; Burden, S.; Pounds, S. B.; Abraham, B.
10.1101/2024.02.01.578210 — molecular biology — Posted on 2025-07-12
558 From paleness to albinism: Contribution of OCA2 exon 10 skipping to hypopigmentation
Mercier, E.; Tregouët, D.-A.; Campagne, S.; Michaud, V.; Green, D. J.; Mesdaghi, S.; Le Gallais, O.; Jouannigot-Castano, O.; Rigden, D. J.; Estay-Ahumada, C.; Hicks, D.; Sergouniotis, P. I.; Arveiler, B.; Javerzat, S.
10.1101/2025.07.10.664067 — genetics — Posted on 2025-07-12
560 Resource landscape shapes the composition and stability of the human vaginal microbiota
Kamiya, T.; Sofonea, M. T.; France, M.; Tessandier, N.; Bravo, I. G.; Murall, C. L.; Ravel, J.; Alizon, S.
10.1101/2024.11.12.622464 — microbiology — Posted on 2025-07-12
562 Structural basis for size-selective perception of chitin in plants
Gysel, K.; Hansen, S. B.; Rübsam, H.; Alsarraf, H. M. A. B.; Madland, E.; Cheng, J. X. J.; Baadegaard, C.; Poulsen, E. C.; Vinther, M.; Fort, S.; Stougaard, J.; Andersen, K. R.
10.1101/2025.07.09.663820 — plant biology — Posted on 2025-07-12
568 Closing the loop: Teaching single-cell foundation models to learn from perturbations
Pershad, Y.; Nandi, T. N.; Van Amburg, J. C.; Parker, A. C.; Ostrowski, L. H.; Giannini, H. K.; Ong, D. A.; Heimlich, J. B.; Obeng, E.; Ericson, K.; Agarwal, A.; Madduri, R. K.; Bick, A. G.
10.1101/2025.07.08.663754 — bioinformatics — Posted on 2025-07-12
569 Hydrogel microdroplet based glioblastoma drug screening platform
Payan, B. A.; De Leon, A. C. D.; Anand, T.; Thompson, G. B.; Boza, A. M.; Krishnamurthy, V. V.; Garcia, A. J.; Harley, B. A. C.
10.1101/2025.07.08.663758 — bioengineering — Posted on 2025-07-12
572 Translation initiation by the Kozak mRNA sequence is based on a conformational readout on the ribosome
von Loeffelholz, O.; Barchet, C.; Holvec, S.; Abou Ramadan, A.; MAGLOTT-ROTH, A.; de Silva, S. N. T.; Hazemann, I.; Klaholz, B.
10.1101/2025.07.11.664391 — biochemistry — Posted on 2025-07-12
577 (-)-Englerin A binds a conserved lipid site of TRPC5 and exposes a Met-aromatic motif in channel activation
Porav, S. A.; Ptakova, A.; Bauer, C. A.; Hammond, k. L. R.; Beech, D. J.; Vlachova, V.; Muench, S. P.; Bon, R. S.
10.1101/2025.07.09.663840 — molecular biology — Posted on 2025-07-12
579 Mechanistic Insights into Keratin Degradation by Onygena corvina
Pavale, S.; Isembart, C.; Shapaval, V.; Tuveng, T. R.; La Rosa, S. L.; Eijsink, V. G. H.
10.1101/2025.07.09.663871 — molecular biology — Posted on 2025-07-12
581 Structural modeling reveals viral proteins that manipulate host immune signaling
Tal, N.; Hadari, R.; Chang, R. B.; Osterman, I.; Jacobson, R.; Yirmiya, E.; Bechon, N.; Hochhauser, D.; Rivera, M. L.; Madhala, B.; Garb, J.; Wein, T.; Kranzusch, P.; Amitai, G.; Sorek, R.
10.1101/2025.07.12.664507 — microbiology — Posted on 2025-07-12
583 Phosphorylation by the PknB serine/threonine kinase stimulates dimer formation by WalR
Suppi, M.; Monk, I. R.; Sharkey, L. K. R.; Scott, N. E.; Goswami, D.; Natarajan, A.; Tan, S.; Myler, K.; Pimentel-Elardo, S. M.; Stinear, T. P.; Pidot, S. J.; Nodwell, J. R.
10.1101/2025.07.12.664526 — microbiology — Posted on 2025-07-12
584 Homozygous kinase-dead Csf1r mutation in outbred mice reveals essential and redundant functions of tissue resident macrophages
Jacquelin, S.; Maxwell, E.; Taylor, I.; Green, E.; O'Brien, C.; Ranpura, G.; Guo, J.; Nooru-Mohamed, F.; Liu, Y.; Keshvari, S.; Huang, S.; Cooper, E.; Lane, S. W.; Flegg, C.; Sokolowski, K.; Pettit, A.; Hume, D. A.; Irvine, K. M.
10.1101/2025.07.08.663807 — immunology — Posted on 2025-07-12
587 Individual differences in learning and decision-making: the role of COMT Val158Met polymorphism in transitive inference
Paul, A.; Segreti, M.; Marc, I. B.; Fiorenza, M. T.; Canterini, S.; Ramawat, S.; Bardella, G.; Pani, P.; Ferraina, S.; Brunamonti, E.
10.1101/2025.07.09.663879 — neuroscience — Posted on 2025-07-12
588 Modulating Cardiac-Gut Microbiome Interaction Post-Myocardial Infarction with Engineered Bacteria
Madaan, T.; Nieman, M.; Rakheja, T.; Siddiqui, N.; Gherardini, D.; Sertorio, M.; Kamble, N.; Thomas, S.; Hartman, A.; Koch, S.; Knipper, L.; Marino, V. A.; Sadayappan, S.; Lorenz, J. N.; Konhilas, J. P.; Kotagiri, N.
10.1101/2025.07.10.664025 — synthetic biology — Posted on 2025-07-12
592 Unraveling the Folding Dynamics of DNA Origami Structures
Mohammadi-Zerankeshi, M.; Houston, J.; Elisha-Wigwe, O. K. U.; Sachi, A.; Marras, A. E.
10.1101/2025.07.11.664431 — bioengineering — Posted on 2025-07-12
595 Structure-activity Relationship for Diarylpyrazoles as Inhibitors of the Fungal Kinase Yck2
Shirley, D. J.; Yiu, B.; Mancera-Ortiz, I.; Stogios, P. J.; Liu, Z.; Robbins, N.; Whitesell, L.; Cowen, L. E.; Drewry, D. H.; Willson, T. M.
10.1101/2025.07.12.664496 — microbiology — Posted on 2025-07-12
596 Mycobacterial cell division arrest and smooth-to-rough envelope transition using CRISPRi-mediated genetic repression systems
Point, V.; Achache, W.; Laudouze, J.; Sepulveda Ramos, E.; Maziero, M.; Crauste, C.; Canaan, S.; Santucci, P.
10.1101/2025.07.12.664508 — microbiology — Posted on 2025-07-12
599 Identifying rare spontaneous mutations through wildtype E. coli population sequencing
Green, R.; Bawn, M.; Angus-Whiteoak, A.; Jago, M.; Whelan, F. J.; Lagator, M.; Hall, N.; Krasovec, R.; Knight, C. G.
10.1101/2025.07.08.663732 — evolutionary biology — Posted on 2025-07-12
600 A new phylogeny and phylogenetic classification for Solanaceae
Deanna, R.; Barboza, G. E.; Bohs, L.; Dodsworth, S.; Gagnon, E.; Giacomin, L.; Knapp, S.; Orejuela, A.; Poczai, P.; Sarkinen, T.; Smith, S. D.; Olmstead, R. G.
10.1101/2025.07.10.663745 — evolutionary biology — Posted on 2025-07-12
601 Protection against reinfection with Mycobacterium tuberculosis extends across heterologous Mtb lineages
Simonson, A. W.; Chao, M. C.; Hood, L. E.; Donlan, R.; Hopkins, F.; Chase, M. R.; Vickers, A. J.; Klein, E.; Borish, H. J.; Malin, M.; Maiello, P.; Scanga, C. A.; Lin, P. L.; Fortune, S. M.; Flynn, J. L.
10.1101/2025.07.08.663727 — immunology — Posted on 2025-07-12
602 Tumor-infiltrating CD27-IgD- regulatory B cells suppress cytotoxic CD8+T cell responses in renal cell carcinoma
Baig, Z.; Withnell, I.; Ng, J. C. F.; Piper, C. J. M.; Bradford, H. F.; Rullan, A.; Arbe-Barnes, E. H.; de Brito, C. G. X.; Di Tullio, A.; Mitchell, T. J.; Stauss, H. J.; Tran, M. G. B.; Fraternali, F.; Mauri, C.
10.1101/2025.07.08.663720 — immunology — Posted on 2025-07-12
603 Cellular basis for cortical network aging in primates
Tsotras, M.; Charbonneau, J. A.; Lepage, C.; Bennett, J. L.; Veraart, J.; Evans, A. C.; Bliss-Moreau, E.; Raven, E. P.
10.1101/2025.07.08.663725 — neuroscience — Posted on 2025-07-12
605 Deep Learning for Sorghum Yield Forecasting using Uncrewed Aerial Systems and Lab-Derived Imagery
Bari, M. A.; Bakshi, A.; Choton, J. C. A.; Pramanik, S.; Witt, T. D.; Caragea, D.; Bean, S.; Jagadish, K.; Felderhoff, T.
10.1101/2025.07.11.663520 — plant biology — Posted on 2025-07-12
608 Convergent Evolution of Sociality Causes Reduction of Mutation Rates in Spiders
Ma, J.; Bechsgaard, J.; Aagaard, A.; Kovacic, I.; Mak, S.; Nesme, J.; P.Gilbert, M. T.; Villesen, P.; Bilde, T.; Schierup, M. H.
10.1101/2025.07.09.663850 — evolutionary biology — Posted on 2025-07-12
610 Map simulator of tick abundance in heterogeneous agricultural landscapes
Vourc'h, G.; Abrial, D.; Agoulon, A.; McCoy, K.; Butet, A.; Verheyden, H.; Loche, R.; Lebert, I.; Perez, G.; Quillery, E.; Chastagner, A.; Leger, E.; Rantier, Y.; Hewison, A. J. M.; Morrelet, N.; Bastian, S.; Hoch, T.; Plantard, O. G. N.
10.1101/2025.07.08.663759 — ecology — Posted on 2025-07-12
613 Exploring the genetic landscape of ciprofloxacin-induced DNA supercompaction in Escherichia coli
Vikedal, K.; Berges, N.; Riisnaes, I. M. M.; Raeder, S. B.; Bjornholt, J. V.; Bjoras, M.; Skarstad, K.; Helgesen, E.; Booth, J. A.
10.1101/2025.07.12.663469 — microbiology — Posted on 2025-07-12
615 Pluripotent stem cell-derived siTNK cells attack tumors via a synthetic CD8-CD28 TCR complex
Zheng, X.; Zhang, F.; Lin, Y.; Hu, F.; Weng, Q.; Liu, P.; Wang, Z.; Zhang, C.; Liu, Y.; Liu, L.; Zhu, Y.; Xiao, Z.; Wang, Y.; Zhang, L.; Qi, H.; Shen, Y.; Chen, Y.; Wu, J.; Xu, J.; Zhao, Y.; Wang, T.; Huang, D.; Xia, C.; Wang, J.; Zhang, M.
10.1101/2025.07.11.663392 — immunology — Posted on 2025-07-12
617 Cell-resolved high-dimensional imaging analysis, therapeutic modeling, and a Phase Ib clinical study validate BCL-2 as a target across heterogeneous CRPC subtypes
Jamroze, A.; Liu, X.; Hou, S.; Li, W.; Yu, H.; Tracz, A.; Li, Q.; Nastiuk, K. L.; Chen, X.; Huang, J.; Lin, K.; Lu, Y.; Puzanov, I.; Kirk, J. S.; Chatta, G.; Tang, D. G.
10.1101/2025.07.08.663739 — cancer biology — Posted on 2025-07-12
619 Targeting DNA-LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity
Marzolini, N.; Brysgel, T. V.; Essien, E.-O.; Rahman, R. J.; Wu, J.; Majumder, A.; Patel, M. N.; Tiwari, S.; Espy, C. L.; Shuvaev, V. V.; Hood, E. D.; Chase, L. S.; Katzen, J. B.; Frank, D. B.; Bennett, M. L.; Marcos-Contreras, O. A.; Myerson, J. W.; Muzykantov, V. R.; Reyes-Esteves, S.; Brenner, J. S.
10.1101/2025.07.09.663747 — bioengineering — Posted on 2025-07-12
623 Accelerating protein engineering with fitness landscape modeling and reinforcement learning
Sun, H.; He, L.; Deng, P.; Liu, G.; Zhao, Z.; Jiang, Y.; Cao, C.; Ju, F.; Wu, L.; Liu, H.; Qin, T.; Liu, T.-Y.
10.1101/2023.11.16.565910 — synthetic biology — Posted on 2025-07-12
627 Directing cellular transitions on gene graph-enhanced cell state manifold
Wang, T.; Pan, Y.; Ju, F.; Zheng, S.; Liu, C.; Min, Y.; Jiang, Q.; Liu, X.; Xia, H.; Liu, G.; Liu, H.; Deng, P.
10.1101/2024.10.27.620174 — cell biology — Posted on 2025-07-12
628 Perineuronal Net and Inhibitory Synapse Remodeling on Striatal Fast-spiking Interneurons by Chronic Alcohol Exposure
Patton, M. S.; Sheats, S. H.; Wulff, A. B.; McKeon, P. N.; VanRyzin, J.; Patton, M. H.; Heckman, M.; Siclair, A. N.; Iffland, P. H.; Mathur, B. N.
10.1101/2025.07.08.663744 — neuroscience — Posted on 2025-07-12
629 Spatially resolved mapping of monoacylglycerol lipase activity in the brain
van der Vliet, D.; Klinkenberg, A. X. Y.; Platte, R.; Higgins, K.; Prokop, S.; Huizenga, M. C. W.; Kraaijevanger, L.; van Egmond, N.; Straub, V. M.; Kole, M. H. P.; Pacher, P.; Katona, I.; Huitinga, I.; van der Stelt, M.
10.1101/2025.07.08.663730 — neuroscience — Posted on 2025-07-12
635 Norepinephrine acts through radial astrocytes in the developing optic tectum to enhance threat detection and escape behavior
Benfey, N. J.; Cookson, F.; Foubert, D.; Cianfarano, E.; Ruge, O.; Benfey, A. T.; Schohl, A.; Ruthazer, E. S.
10.1101/2025.07.10.664211 — neuroscience — Posted on 2025-07-12
637 Uncertainty in Deep Learning for EEG under Dataset Shifts
Tveter, M.; Tveitstoel, T.; Hatlestad-Hall, C.; Hammer, H. L.; Haraldsen, I. R. J. H.
10.1101/2025.07.09.663220 — neuroscience — Posted on 2025-07-12
638 Structural variability of apolipoprotein A-I amyloid fibrils across organs, mutations, and clinical presentations, revealed by cryo-EM
Nguyen, B. A.; Fernandez Ramirez, M. d. C.; Bassett, P. T.; Singh, V.; Singh, P.; Pekala, M.; Villalon, L.; Ahmed, Y.; Lemoff, A.; Evers, B. M.; Lopez, C.; Kluve-Beckerman, B.; Saelices, L.
10.1101/2025.07.08.663734 — biophysics — Posted on 2025-07-12
639 Identification of novel protective loci for executive function using the trail making test part B in the Long Life Family Study
Wang, L.; Tanner, K.; Andersen, S. L.; Cosentino, S.; Moghaddam, V. A.; Daw, E. W.; Anema, J. A.; Lin, S. J.; Acharya, S.; Province, M.; Wojczynski, M. K.
10.1101/2025.07.08.663708 — genomics — Posted on 2025-07-12
642 Refate identifies chemical compounds to target trans-regulatory networks for cellular conversion
Xiao, D.; Sahadevan, S.; Mangala, M. M.; Kim, H. J.; Fredericks, A.; Huang, H.; Jothi, R.; Tam, P.; Gonzalez-Cordero, A.; Zyner, K. G.; Yang, P.
10.1101/2025.07.09.664003 — developmental biology — Posted on 2025-07-12
644 Choice of lipid supplementation for in vitro erythroid cell culture impacts reticulocyte yield and characteristics
Freire, C. M.; King, N. R.; Dzieciatkowska, M.; Stephenson, D.; Dobbe, j. G.; Streekstra, G. J.; D'Alessandro, A.; Satchwell, T. J.; Toye, A. M.
10.1101/2025.07.11.664344 — cell biology — Posted on 2025-07-12
645 Paralemmin-3 sustains the integrity of the lateral plasma membrane and subsurface cisternae of auditory hair cells
Halim, V. C.; Bahader, I.; Derstroff, D.; Ullrich, C.; Kuwabara, M.; Hultqvist, G.; Kusch, K.; Slitin, L. C.; Becker, L.; Hrabe de Angelis, M.; Wichmann, C.; Oliver, D.; Strenzke, N.; Vogl, C.; Kilimann, M.
10.1101/2025.07.11.664127 — cell biology — Posted on 2025-07-12
646 Deletion of the scavenger receptor Scarb1 in osteoblast progenitors and myeloid cells does not affect bone mass
Palmieri, M.; Joseph, T. E.; Gomez-Acevedo, H.; Kim, H.-n.; Manolagas, S. C.; O'Brien, C. A.; Ambrogini, E.
10.1101/2025.07.09.663826 — cell biology — Posted on 2025-07-12
648 Regnase-1 Promotes Tumor-Initiating Activity in Non-Small Cell Lung Cancer
Okazaki, K.; Kawaguchi, M.; Murakami, S.; Takeda, H.; Sekine, H.; Takeuchi, O.; Motohashi, H.
10.1101/2025.07.08.663650 — cancer biology — Posted on 2025-07-11
649 Exploring CDK4/6-Dependencies in ex vivo Ovarian Cancer Models
Mcdonald-Pike, J.; Coulson-Gilmer, C.; Littler, S.; Barnes, B. M.; Altringham, J.; Tighe, A.; McGrail, J. C.; Taylor, S. S.
10.1101/2025.07.11.664318 — cancer biology — Posted on 2025-07-12
651 Expanding the repertoire of chemically induced covalent neoantigens
Zhou, C.; Huang, W.; Jin, X.; Wu, H.; McGregor, L. M.; Schirle, M.; Zhang, C.; Zhang, X.
10.1101/2025.07.08.663715 — biochemistry — Posted on 2025-07-12
652 Renin Cells Drive Kidney Neurovascular Development and Arterial Remodeling when Renin Activity is Deficient
Yamaguchi, M.; Yamaguchi, H.; Smith, J. P.; Ferreira de Almeida, L.; Matsuoka, D.; Martini, A. G.; Wilmsen, S. M.; Hao, S.; Tainaka, K.; Medrano, S.; Sequeira-Lopez, M. L. S.; Gomez, R. A.
10.1101/2025.07.08.663706 — developmental biology — Posted on 2025-07-12
653 A complex of MAST1 and 14-3-3 regulates Tau phosphorylation in the developing cortex
Antonioli, S.; Heisterkamp, P.; Chen, W.; Anrather, D.; Hartl, M.; Martinez-Reza, M.-F.; Tripathy, R.; Schutzbier, M.; Mechtler, K.; Keays, D. A.; Leonard, T. A.
10.1101/2025.07.09.663707 — molecular biology — Posted on 2025-07-11
658 Domain-General Brain Networks Support Language Development
Zhou, Z.; Yang, X.; Ju, P.; Rong, M.; Jefferies, E.; Zuo, X.-N.
10.1101/2025.07.10.663607 — neuroscience — Posted on 2025-07-12
660 Liver FGF21 mediates sex-specific adaptation to juvenile protein malnutrition
Joly, A.; Rebiffe, L.; Lambert, A.; Caillon, E.; Hughes, S.; Gillet, B.; Rahioui, I.; Da Silva, P.; Bruse, J.; Fougerat, A.; De Vadder, F.; Leulier, F.
10.1101/2025.07.09.663702 — physiology — Posted on 2025-07-11
661 Conformational plasticity of LptC regulates lipopolysaccharide transportby the LptB2FGC complex
Klausnitzer, A.; Kaur, J.; Rath, T.; Seidl, S.; Becker-Baldus, J.; Morgner, N.; Glaubitz, C.
10.1101/2025.07.09.663713 — biophysics — Posted on 2025-07-11
663 Synthesis errors in oligonucleotides are propagated into the genome by homology-directed repair
Wyman, S. K.; Romero, Z.; Heo, S.-J.; Navarrete, M.; Krishnappa, N.; Kohn, D. B.; Martin, D. I.; Walters, M. C.; Boffelli, D.
10.1101/2025.07.08.663753 — genomics — Posted on 2025-07-11
668 Elucidating continental-wide phylogeographic and adaptive processes shaping the genome-wide diversity of North America's most widely distributed tree
Goessen, R.; isabel, n.; Wehenkel, C.; Hernandez-Velasco, J.; Mendoza-Maya, E.; Saenz-Romero, C.; Blanco-Garcia, A.; Bousquet, J.; Porth, I.
10.1101/2025.07.08.663217 — evolutionary biology — Posted on 2025-07-11
672 Higher-order epistasis drives evolutionary unpredictability toward novel antibiotic resistance
Gaszek, I. K.; Yildiz, M. S.; Meng, Z.; de la Paz, J. A.; Alvarez, S. M.; Morcos, F.; Lin, M. M.; Toprak, E.
10.1101/2025.07.08.663783 — evolutionary biology — Posted on 2025-07-11
673 Developmental system drift in the patterning of the arthropod tarsus
Klementz, B. C.; Neu, S. M.; Laumer, E. M.; Setton, E. V. W.; Hinne, I. A.; Barnett, A. A.; Hämmerle, M.; Brenneis, G.; Gulia-Nuss, M.; Sharma, P. P.
10.1101/2025.07.08.663771 — evolutionary biology — Posted on 2025-07-11
675 Pre-Sequencing Assessment of RNA-Seq Library Quality Using Real-Time qPCR
Kottapalli, K.; Chao, H.; Jiang, Q.; Donelson, J.; Emerick, N.; Bhamidipati, S. V.; Momin, Z.; Mathew, T.; Khan, Z.; Korchina, V.; Gingras, M.-C.; muzny, d. m.; Gibbs, R. A.; Doddapaneni, H. V.
10.1101/2025.07.08.663710 — molecular biology — Posted on 2025-07-11
677 Deep mapping of the endomembrane system of cerebellar Purkinje neurons
Haberl, M. G.; Viana da Silva, S.; Phan, S.; Bushong, E.; Deerinck, T.; Ellisman, M. H.
10.1101/2025.07.08.663701 — neuroscience — Posted on 2025-07-11
679 A novel, evolutionarily conserved inhibitory circuit selectively regulates dentate gyrus mossy cell function.
Vargish, G. A.; Rice, H.; Yuan, X.; Hunt, S.; Hines, B. E.; Plotnikova, A.; Mohanty, A.; Furlanis, E.; Wang, Y.; Dai, M.; Garcia, B. L.; Cummins, A. C.; Eldridge, M. A. G.; Averbeck, B. B.; Zaghloul, K. A.; Dimidschstein, J.; Fishell, G.; Pelkey, K. A.; McBain, C. J.
10.1101/2025.07.09.663808 — neuroscience — Posted on 2025-07-11
681 An efficient beet severe curly top virus-based VIGS vector in Beta vulgaris
Nie, Z.; Guo, Z.; Qin, X.; Liu, Q.; Zhou, M.; Ye, J.; Zhang, Z.; Han, C.; Wang, Y.
10.1101/2025.07.11.663803 — plant biology — Posted on 2025-07-11
682 A Comprehensive Toxicological Safety Evaluation of Anaerostipes caccae
Modica, V.; Glavits, R.; Clewell, A.; Endres, J. R.; Hirka, G.; Vertesi, A.; Beres, E.; Szakonyine, I. P.
10.1101/2025.07.08.663675 — pharmacology and toxicology — Posted on 2025-07-11
683 Histone methyl-transferase G9a inhibition boosts the efficacy of immune checkpoint inhibitors in experimental hepatocellular carcinoma
Adan-Villaescusa, E.; Castello-Uribe, B.; Uriarte, I.; Santamaria, E.; Barbero, R.; Belzunce, M.; Lopez-Pascual, A.; Latasa, M. U.; Elurbide, J.; Valbuena-Goiricalaya, E.; Vespasiani-Gentilucci, U.; Prosper, F.; Pineda-Lucena, A.; Sangro, B.; Argemi, J.; Berraondo, P.; Sarobe, P.; Arechederra, M.; Berasain, C.; Cocozaki, A.; Gibaja, V.; Avila, M. A.; Fernandez-Barrena, M. G.
10.1101/2025.07.08.663670 — pharmacology and toxicology — Posted on 2025-07-11
684 Temporal foundation model unveils ancient HepatitisB virus evolution
Qi, J.; Sun, B.; Liu, Y.; Xiao, X.; Zhou, M.; Herbig, A.; Yang, C.; Han, X.; Cui, Y.; Guan, R.
10.1101/2025.07.09.663843 — paleontology — Posted on 2025-07-11
688 A Microfluidic Blood Vessel-On-Chip Model of Thrombosis
Jansson-Edqvist, J.; Mencarini, T.; Peghaire, C.; Dibble, M.; Ahnstroem, J.; Pericleous, C.; Redaelli, A.; van Batenburg-Sherwood, J.; Randi, A. M.
10.1101/2025.07.10.663679 — bioengineering — Posted on 2025-07-11
690 Convergent DNA Methylation Abnormalities at Bivalent Chromatin in Human Growth Disorders
Strauss, M. E.; Takahashi, Y.; Lee, J.; Perez, C.; Chen, X.; Lee, Y.; Pope, Z. S.; Yun, H.; Weirauch, M. T.; Byun, M.
10.1101/2025.07.08.663614 — genomics — Posted on 2025-07-11
692 Patterns of compensatory mutations in rpoA/B/C genes of multidrug resistant M. tuberculosis in Uganda
Kateete, D. P.; Namakula, S.; Kigozi, E.; Katabazi, F. A.; Kasule, G. W.; Musisi, K.; Wampande, E.; Lukoye, D.; Joloba, M. L.
10.1101/2025.07.11.664293 — microbiology — Posted on 2025-07-11
696 Improved Source Localization of Auditory Evoked Fields using Reciprocal BEM-FMM
Drumm, D. A.; Nunez Ponasso, G. C.; Linke, A.; Noetscher, G. M.; Maess, B.; Knösche, T. R.; Haueisen, J.; Lewine, J. D.; Abbott, C. C.; Makaroff, S. N.; Deng, Z.-D.
10.1101/2025.05.09.653081 — neuroscience — Posted on 2025-07-11
699 Weighted sliced inverse regression for scalable supervised dimensionality reduction of spatial transcriptomics data
Woollard, M.; Panwar, P.; Harland, L.; Mo, J.; Zhang, H.; Swarbrick, A.; Gottgens, B.; Ghazanfar, S.; Nghiem, L.
10.1101/2025.07.08.663651 — genomics — Posted on 2025-07-11
700 A Cell Type Enrichment Analysis Tool for Brain DNA Methylation Data (CEAM)
Muller, J.; Laroche, V.; Imm, J.; Weymouth, L.; Harvey, J.; Smith, A. R.; van den Hove, D.; Lunnon, K.; Cavill, R.; Pishva, E.
10.1101/2025.07.08.663671 — genomics — Posted on 2025-07-11
702 Enhanced cleavage of genomic CCR5 using CASX2Max
Hodge, C. A.; Donegan, N. P.; Armstrong, D. A.; Howell, A. L.; Hayden, M. S.
10.1101/2025.07.08.663680 — molecular biology — Posted on 2025-07-11
703 Genes on the Move: Exploring the Resistome of Viable Isolates from a First Nation Community in Manitoba
Patel, R.; Zambrano-Alvarado, J.; Rudin, N.; Zhang, K.; Adeniji, A.; Moniruzzaman, M.; Uyaguari, M. I.
10.1101/2025.07.11.664311 — microbiology — Posted on 2025-07-11
704 The gut microbiota and sleep in infants: a focus on diurnal rhythmicity patterns
Kerff, F.; Muehlematter, C.; Adamov, A.; Fast, D.; Pluess, S.; Zimmermann, P.; Kurth, S.; Bokulich, N. A.
10.1101/2025.07.11.664337 — microbiology — Posted on 2025-07-11
705 Tissue destruction during food spoilage is associated with the formation of biofilms by Pseudomonas species
Nolan, L. M.; Lazenby, J. J.; Sweet, R.; Wickham, G. J.; Al-Khanaq, H.; Bloomfield, S. J.; Mather, A. E.; Whitchurch, C. B.
10.1101/2025.07.11.664243 — microbiology — Posted on 2025-07-11
706 Synergy between HA cleavage site sequence and NA-mediated plasminogen recruitment as a virulence mechanism for low pathogenic avian influenza
Lee, H. M.; Sutton, K.; Harvey, W.; Pinto, R. M.; Gaunt, E. R.; Lycett, S. J.; de Wit, S.; Vervelde, L.; Digard, P.
10.1101/2025.07.11.664276 — microbiology — Posted on 2025-07-11
707 Development of enterovirus trans-encapsidation assays as tools to understand viral entry.
Hall, P. K.; Cassani, N.; Jardim, A. C. G.; Rowlands, D. J.; Kingston, N. J.; Stonehouse, N. J.
10.1101/2025.07.11.664324 — microbiology — Posted on 2025-07-11
717 Substituent-based Modulation of Self-Assembly and Immunogenicity of Amphipathic Peptides
Das, A.; Pramanik, U.; Brown, E. M.; Liu, C.-Y.; Gong, H.; Fascetti, J.; Gibson, M.; Stealey, S.; Zustiak, S. P.; Berkland, C.; Jackrel, M. E.; White, M. A.; Rudra, J. S.
10.1101/2025.07.08.663637 — bioengineering — Posted on 2025-07-11
718 From Smartphone Images to Musculoskeletal Models: Personalized Inertial Parameter Estimation
Gambietz, M.; Azam, P. Q.; Amon, P.; Wechsler, I.; Hille, E. M.; Menzel, T.; Ott, T.; Botsch, M.; Braun, M.; Miehling, J.; McMahon, K. L.; Koelewijn, A. D.
10.1101/2025.07.08.663673 — bioengineering — Posted on 2025-07-11
721 Confounding Fuels Misinterpretation in Human Genetics
Benning, J. W.; Carlson, J.; Smith, O.; Shaw, R.; Harpak, A.
10.1101/2023.11.01.565061 — genetics — Posted on 2025-07-11
722 Targeting NEDD9-SH3 with a Covalent Peptide Controls Endothelial Phenotype
Samokhin, A.; Seo, H.-S.; Leed, A.; Hajiian, B.; McKinney, D.; Saha, P.; Daum, J.; Moroco, J.; Yehl, J.; Kornfilt, D.; Sczceniowski, A.; Petrunak, E.; Horner, S.; Kaylin, J.; Leymarie, N.; Kaushik, V.; Cole, P.; Oldham, W.; Steinhauser, M.; Dhe-Paganon, S.; Maron, B.; Bird, G.; Walensky, L.
10.1101/2025.07.10.663547 — molecular biology — Posted on 2025-07-11
726 c-di-GMP-Dependent Regulation of Motility by comFB and comFC
Hahn, J.; Celma, L.; El-shereef, A.; Samir, S.; Dubnau, E.; Selim, K. K.; DUBNAU, D.
10.1101/2025.07.11.664319 — microbiology — Posted on 2025-07-11
727 Metabolic reprogramming of methylthioadenosine-dependent sulfur recycling is a major driver of CHIKV infection
Muema, J. M.; Friemelt, M.; Overwin-Moser, H.; Beutling, U.; Franke, R.; Broenstrup, M.; Sandner, P.; Bilitewski, U.
10.1101/2025.07.11.664323 — microbiology — Posted on 2025-07-11
730 Combinatorial pathway engineering using multiplex Serine recombinase-Assisted Genome Engineering (mSAGE)
Huenemann, J. D.; Carroll, A. L.; Elmore, J. R.; Dexter, G.; Mand, T.; Klingeman, D. M.; Alexander, W.; Guss, A. M.
10.1101/2025.07.11.664204 — microbiology — Posted on 2025-07-11
732 Temporal regulation of metabolic processes in the marine diazotroph Crocosphaera watsonii WH 8501
Gauglitz, J. M.; Inomura, K.; Bittremieux, W.; Moran, D. M.; McIlvin, M. M.; Saito, M. A.
10.1101/2025.07.11.664471 — microbiology — Posted on 2025-07-11
733 Neuronal migration depends on blood flow in the adult brain
Ogino, T.; Saito, A.; Sawada, M.; Takemura, S.; Hara, Y.; Yoshimura, K.; Nagase, J.; Kawase, H.; Sato, T.; Inada, H.; Herranz-Perez, V.; Mukouyama, Y.-S.; Ema, M.; Garcia-Verdugo, J. M.; Nabekura, J.; Sawamoto, K.
10.1101/2024.05.16.594485 — neuroscience — Posted on 2025-07-11
734 The cryo-EM-delineated mechanism underlying mimicry of CXCR4 agonism enables widespread stem cell neuroprotection in a mouse model of ALS
Sang, X.; Jiao, H.; Meng, Q.; Fang, X.; Sundaram, K. S.; Zhou, J.; Xu, Y.; Alvarado, A. I. W.; Nuryyev, R. L.; Ourenik, J.; Ourednik, V.; Huang, I. S.; Liu, X.; Mei, Y.; Qian, T.; Ciechanover, A.; Pizzo, D. P.; Lane, M. A.; Zholudeva, L. V.; An, J.; Snyder, E. Y.; Hu, H.; Huang, Z.
10.1101/2025.07.08.663251 — neuroscience — Posted on 2025-07-11
735 Proteomic and in silico dissection of MetaAggregates in amyotrophic lateral sclerosis brains
Murakami, K.; Nguyen, T. H. V.; Fujita, N.; Nagao, C.; Mizuguchi, K.; Nishiuchi, T.; Sakashita, Y.; Noguchi-Shinohara, M.; Ono, K.
10.1101/2025.07.09.663594 — neuroscience — Posted on 2025-07-11
736 Motor Cortex Modulates Ipsilateral Limb Movement Through a Direct Cortico-Cerebellar Circuit
Schaefer, C. B.; Oliveira Silva, R.; Hasanbegovic, H.; Adolfs, Y.; Pasterkamp, J.; Li, X.; Li, A.; Gong, H.; De Zeeuw, C.; Hoebeek, F.; Gao, Z.
10.1101/2025.07.08.663625 — neuroscience — Posted on 2025-07-11
738 Constructing the first comorbidity networks in companion dogs in the Dog Aging Project
Fang, A.; Kumar, L.; Creevy, K. E.; Dog Aging Project Consortium, ; Promislow, D. E. L.; Ma, J.
10.1101/2024.12.18.629088 — physiology — Posted on 2025-07-11
740 Collective Gene Expression Fluctuations Encode the Regulatory State of Cells
Olmeda, F.; Dang, Y.; Rost, F.; Schimmenti, V. M.; Di Terlizzi, I.; Rulands, S.
10.1101/2025.07.09.663203 — biophysics — Posted on 2025-07-11
743 Modeling Hepatocellular Carcinoma and its microenvironment on a chip
Mocellin, O.; Treillard, S.; Robinson, A.; Olczyk, A.; Olivier, T.; Ng, C. P.; Stok, A.; van Tienderen, G.; Verstegen, M. M. A.; Heijmans, J.; Kurek, D.; Trietsch, S. J.; Lanz, H.; Vulto, P.; Joore, J.; Queiroz, K.
10.1101/2025.07.10.663127 — bioengineering — Posted on 2025-07-11
745 Early-life stress as a potential resilience factor in king penguins
Fernandes, F. A. N.; Bardon, G.; Paris, J. R.; Ancona, L.; Cristofari, R.; Obiol, J. F.; Greco, S.; Gerdol, M.; Vallas, B.; Carette, P.; Le Bohec, C.; Trucchi, E.
10.1101/2025.07.10.663151 — genomics — Posted on 2025-07-11
746 Beyond the transcript: chromatin implications in trans-splicing in Trypanosomatids
Zambrano Siri, R. T.; Beati, P.; Inchausti, L.; Smircich, P.; Alonso, G. D.; Ocampo, J.
10.1101/2025.07.08.663533 — genomics — Posted on 2025-07-11
749 Longitudinal dynamics of ethanol-resistant microbes and sporulation in the human gut
Miklavcic, U.; Mahnic, A.; Shoemaker, W. R.; Grilli, J.; Janezic, S.; Rupnik, M.
10.1101/2025.07.08.663423 — ecology — Posted on 2025-07-11
750 Cell atlas of the developing human meninges reveals a dura origin of meningioma
Vinsland, E.; Marco Salas, S.; Kapustova, I.; Hu, L.; Webb, S.; Li, X.; He, X.; Nilsson, M.; Hanifa, M.; Barker, R. A.; Persson, O.; Raleigh, D. R.; Sundstrom, E.; Lonnerberg, P.; Linnarsson, S.
10.1101/2025.07.08.663122 — developmental biology — Posted on 2025-07-11
752 Scar-associated endothelial-stellate cellular crosstalk drives fibrosis resolution in MASH
Li, K.; Kumar, V.; To, T.; Yu, M.; Cogliati, B.; Chittampalli, Y. N.; Miller, M.; Branch, A. D.; Giotti, B.; Tsankov, A. M.; Chen, L.; Petitjean, M.; Lu, C.; Li, Y.; Bhatia, S. N.; Friedman, S. L.; Wang, S.
10.1101/2025.07.08.663293 — molecular biology — Posted on 2025-07-11
753 Twitching motility suppressors reveal a role for FimX in type IV pilus extension dynamics
Roberge, N.; Yuen, N.; Harvey, H.; Ellison, T. J.; Ellison, C. K.; Burrows, L. L.
10.1101/2025.07.10.664058 — microbiology — Posted on 2025-07-11
757 Astrocytic mGluR5 signaling tunes emotional and cognitive processing in the adult brain
Viana, J. F.; Dias, J. D.; Gonzalez-Arias, C.; Alves, L. S.; Veiga, A.; Abreu, D. S.; Machado, J. L.; Barsanti, S.; Nobre, R. J.; Pereira de Almeida, L.; Perea, G.; Oliveira, J. F.
10.1101/2025.07.07.663457 — neuroscience — Posted on 2025-07-11
758 The somatosensory barrel cortex controls the spindlethalamocortical oscillation by frequency locking
Guevara, R.; Tambaro, M.; Maschietto, M.; Leparulo, A.; Checchetto, C.; Nicoletti, G.; Mariani, B.; Suweis, S.; Vassanelli, S.
10.1101/2025.07.09.662963 — neuroscience — Posted on 2025-07-11
759 Prevenying vision loss in a mouse model of Leber Congenital Amaurosis by engineered tRNA
Pattnaik, B. R.; Akyuz, E.; Shahi, P. K.; Gissot, L.; Saneh, A. A.; Sinha, D.; Hanstad, G.; Kabra, M. R.; Zepeda, M. A.; Gamm, D. M.; Young, S. M.; Ahern, C. A.
10.1101/2025.07.10.660754 — physiology — Posted on 2025-07-11
760 Borna disease virus 1 infection causing fatal meningoencephalomyelitis in wild European hedgehogs in known endemic areas, Germany, 2022 to 2024
Michelakaki, E.; Schade, B.; Boehm, B.; Kappe, E.; Suchowski, M.; Kupca, A.; Schumacher, M.; Gager, A. M.; Liesche-Starnecker, F.; Bago, Z.; Blutke, A.; Beer, M.; Rubbenstroth, D.; Matiasek, K.
10.1101/2025.07.08.663648 — pathology — Posted on 2025-07-11
762 Selective Sensitivity of Ph-like B-ALL to BRG1 Inhibition Reveals a Novel Targeted Therapy Strategy
Ayyadevara, V. S. S. A.; Gaur, S.; Paik, A.; Perencsik, R.; Toma, M. M.; Wertheim, G.; Geng, H.; Skorski, T.; Swaminathan, S.; Hurtz, C.
10.1101/2025.07.08.661805 — cancer biology — Posted on 2025-07-11
769 Quantitative Economon Model of Transactions for Drugs and Other Commodities
Haynes, J. M.; Correa da Rosa, J. M.; Butelman, E.; Hursh, S. R.; Negus, S. S.
10.1101/2025.07.08.663082 — bioinformatics — Posted on 2025-07-11
770 Deep-learning-assisted SICM for enhanced real-time imaging of nanoscale biological dynamics
Ayar, Z.; Penedo, M.; Drake, B.; Shi, J.; Mendes Leitao, S.; Krawczuk, I.; Miljkovic, H.; Radenovic, A.; Ban, J.; Cevher, V.; Fantner, G. E.
10.1101/2025.07.08.663539 — bioengineering — Posted on 2025-07-11
773 Human emotional odours influence horses' behaviour and physiology
Jardat, P.; Destrez, A.; Damon, F.; Tanguy-Guillo, N.; Laine, A.-L.; Parias, C.; Reigner, F.; Ferreira, V. H. B.; Calandreau, L.; Lansade, L.
10.1101/2025.07.08.663503 — animal behavior and cognition — Posted on 2025-07-11
774 UVA irradiation promotes ROS-mediated formation of the common deletion in mitochondrial DNA
Fontana, G. A.; Singh, N. K.; Rotankova, N.; Eichelberg, A.; Di Filippo, M.; Macarthur, M.; Heldmaier, S.; Wandrey, F.; Beer, H.-D.; Sturla, S. J.; Gahlon, H.
10.1101/2025.07.09.663484 — genomics — Posted on 2025-07-11
780 Tmbim5 and Slc8b1 cooperate in tissue-specific mitochondrial calcium regulation in zebrafish
Wasilewska, I.; Adamek-Urbanska, D.; Baranykova, S.; Majewski, L.; Macias, M.; Szybinska, A.; Methner, A.
10.1101/2024.12.03.626543 — cell biology — Posted on 2025-07-11
781 Epigenetic remodeling via HDAC6 inhibition amplifies anti-tumoral immune responses in myeloid leukemia cells
Schliehe-Diecks, J.; Tu, J.-W.; Stachura, P.; Schaal, K.; Kemkes, M.; Vasileiou, E.; Ruechel, N.; Brandes, D.; Vogt, M.; Lenz, T.; Nair, A.; Scheu, S.; Dominguez, P.; Pastorczak, A.; Nebral, K.; Stuehler, K.; Fischer, U.; Pandyra, A.; Borkhardt, A.; Bhatia, S.
10.1101/2025.05.30.654805 — cell biology — Posted on 2025-07-11
782 Selective silencing of antibiotic-tethered ribosomes as a resistance mechanism against aminoglycosides
Ghosh Dastidar, N.; Freyer, N. S.; Petrychenko, V.; Schwarzer, A. C.; Peng, B.-Z.; Samatova, E.; Kothe, C.; Schmidt, M.; Peske, F.; Politi, A.; Urlaub, H.; Fischer, N.; Rodnina, M. V.; Wohlgemuth, I.
10.1101/2025.07.08.660097 — molecular biology — Posted on 2025-07-11
783 Spatial mapping of proteins and their activity states in cancer models by multiplex in situ PLA
Lof, L.; Xu, B.; Sinha, T. K.; Dahlstrom, C. M.; Vennberg, J.; Larsson Forssen, T.; Klaesson, A.; Clausson, C.-M.; Wang, X.; Kamali-Moghaddam, M.; Avenel, C.; Wahlby, C.; Zieba-Wicher, A.; Landegren, U.
10.1101/2025.07.11.662357 — molecular biology — Posted on 2025-07-11
784 Unravelling the role of epigenetic regulators during embryonic development of Rhipicephalus micropolus
Amarante, A. d. M.; de Oliveira, D. M.; de Souza, M. P. N. C.; Oliveira, M. F.; Galina, A.; Rosignoli, S.; Arcanjo, A. F.; Moraes, B.; Paiardini, A.; Li Yasumura, J. D. d. P.; Henaut-Jacobs, S.; Venancio, T. M.; Uhl, M.; da Fonseca, R. N.; Parizi, L. F.; Vaz Junior, I. d. S.; Mermelstein, C. d. S.; Tirloni, L.; Logullo, C.; Fantappie, M. R.
10.1101/2025.07.11.662657 — molecular biology — Posted on 2025-07-11
787 3D co-cultures of primary human hepatocytes and Kupffer-like cells to address innate immune responses to rAAV
Gal, I. R.; Arez, F.; Correia, I. P.; Domenici, G.; Fernandes, S.; Silva, G.; Saldanha, I.; Duarte, N.; Freitas, C.; Alves, P. M.; Maier, U.; Coroadinha, A. S.; Du Plessis, F.; Brito, C.
10.1101/2025.07.08.663523 — immunology — Posted on 2025-07-11
788 Selective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity
Castillo, J. G.; Silveria, S.; Sauquet, A.; Schirokauer, L.; Hendricks, J.; Olzmann, J.; Sul, H. S.; DuPage, M.
10.1101/2025.07.06.663397 — immunology — Posted on 2025-07-11
789 Colitis-primed circulating T cells drive small intestinal barrier function through Nod2, microbiota and myosin light chain kinase-dependent mechanisms
Mauduit, A.; Nabhani, T.; Morelli, L.; Cherrier, F.; Abdoul Ahad, R.; Nabhani, N.; Singh, G.; Roy, M.; Dietrich, G.; Turner, J. R.; Hugot, J.-P.; Macpherson, A.; Mas, E.; Barreau, F.; Al Nabhani, Z.
10.1101/2025.07.10.663215 — immunology — Posted on 2025-07-11
790 Immunosuppressants Rewire the Gut Microbiome-Alloimmune Axis Through Time-Dependent and Tissue-Specific Mechanisms
Wu, L.; Kensiski, A.; Gavzy, S.; Song, Y.; Lwin, H. W.; France, M.; Kong, D.; Li, L.; Lakhan, R.; Saxena, V.; Piao, W.; WillsonShirkey, M.; Mas, V.; Lohmsr, B.; Bromberg, J. S.; Ma, B.
10.1101/2025.01.02.631100 — immunology — Posted on 2025-07-11
791 Individuality across environmental context in Drosophila melanogaster
Mathejczyk, T.; Knief, C.; Haidar, M. A.; Freitag, F.; McClary, T.; Wernet, M. F.; Linneweber, G. A.
10.1101/2023.11.26.568741 — neuroscience — Posted on 2025-07-11
792 A non-invasive approach to awake mouse fMRI compatible with multi-modal techniques
Laxer, S.; Eed, A.; Bellyou, M.; Zeman, P.; Gilbert, K. M.; Naderi, M.; Menon, R. S.
10.1101/2025.01.23.634586 — neuroscience — Posted on 2025-07-11
793 Uncertainty in Deep Learning for EEG under Dataset Shifts
Tveter, M.; Tveitstoel, T.; Hatlestad-Hall, C.; Hammer, H. L.; Haraldsen, I. R. J. H.
10.1101/2025.07.09.663220 — neuroscience — Posted on 2025-07-11
795 Dysregulated nuclear Lamin B1 in DYT1 dystonia thickens the nuclear lamina and disrupts 14-3-3 proteins
Duan, Y.; Sepehrimanesh, M. L.; Hosain, M. A.; Cui, H.; Stagray, J.; Shen, X.; Xiao, Y.; Li, Y.; Zhang, C.-L.; Ding, B.
10.1101/2025.07.09.662391 — neuroscience — Posted on 2025-07-11
801 MCWs (MiCroWire sorter): A new framework for automated and reliable spike sorting in human intracerebral recordings.
Brahma, T.; Khani, M.; Chaure, F. J.; Hauder, C.; Mathew, S.; Dominguez Zesati, A. S.; Lew, S.; Gupta, K.; Rey, H. G.
10.1101/2025.07.09.663285 — neuroscience — Posted on 2025-07-11
802 Ploidy alters root anatomy and shapes the evolution of wheat polyploids
Sidhu, J. S.; Gill, H. S.; Walker, S.; Rangarajan, H.; Lopez-Valdivia, I.; Singh, M.; Sawers, R. J.; Sehgal, S.; Lynch, J.
10.1101/2025.07.11.663263 — plant biology — Posted on 2025-07-11
803 Evolutionarily conserved temperature dependency leads to loss of protein O-GlcNAc in mammalian hypothermia
Upadhyay, D.; Kietz, C.; Sultana, N.; Banerjee, R.; Kankare, M.; Fellman, V.; Purhonen, J.; Kallijarvi, J.
10.1101/2025.07.08.660373 — physiology — Posted on 2025-07-11
804 A Fibroblast State Choreographs an Epithelial YAP-dependent Regenerative Program Essential to (Pre)malignancy via ECM-mediated Mechanotransduction
Pan, D.; Gascard, P.; Caruso, J. A.; Chen-Tanyolac, C.; Sangwan, V.; Bertos, N.; Camilleri-Broet, S.; Berube, J.; Oikonomopoulos, S.; Strasser, M. K.; Gibbs, D. L.; Bons, J.; Burton, J. B.; Rose, J. P.; Shah, S.; Bai, R.; Lee, S.; Fels-Elliott, D. R.; Miyara, S.; Alon, U.; Urisman, A.; Ragoussis, I.; Huang, S.; Schilling, B.; Ferri, L. E.; Tlsty, T. D.
10.1101/2025.07.11.661192 — cancer biology — Posted on 2025-07-11
806 In situ protein crystallography: a single-crystal electron diffraction pipeline for structure determination inside living cells.
Bila, S.; Pinkas, D.; Khakurel, K.; Boger, J.; Bily, T.; Hajdu, J.; Franta, Z.; Tuma, R.; Redecke, L.; Polovinkin, V.
10.1101/2025.07.08.663504 — biophysics — Posted on 2025-07-11
809 f-BGM enables fungi-specific genome mining in high accuracy and interpretability
Zhou, Y.; Liu, D.; Huang, Z.; Xie, X.; Lin, W.; Zhang, L.; Fan, A.; Liu, Z.
10.1101/2025.07.08.662937 — bioinformatics — Posted on 2025-07-11
810 Prediction and functional interpretation of inter-chromosomal genome architecture from DNA sequence with TwinC
Jha, A.; Hristov, B.; Wang, X.; Wang, S.; Greenleaf, W.; Kundaje, A.; Aiden, E. L.; Bertero, A.; Noble, W. S.
10.1101/2024.09.16.613355 — bioinformatics — Posted on 2025-07-11
813 Context-dependent regulatory variants in Alzheimer's disease
Chen, Z.; Liu, Y.; Brown, A. R.; Sestili, H.; Ramamurthy, E.; Xiong, X.; Prokopenko, D.; Phan, B. N.; Gadey, L.; Hu, P.; Tsai, L.-H.; Bertram, L.; Hide, W.; Tanzi, R. E.; Kellis, M.; Pfenning, A. R.
10.1101/2025.07.11.659973 — genomics — Posted on 2025-07-11
814 A stress-dependent postembryonic role for the core CPA factor CFIM-1 in germline integrity
Sathaseevan, A.; Ahluwalia, R.; Yu, B.; Makhenko-Tang, C.; Nishimura, H.; Leong, A.; Kwan, K. N. N.; Derry, B.
10.1101/2025.07.01.662614 — developmental biology — Posted on 2025-07-11
819 From paleness to albinism: Contribution of OCA2 exon 10 skipping to hypopigmentation
Mercier, E.; Tregouët, D.-A.; Campagne, S.; Michaud, V.; Green, D. J.; Mesdaghi, S.; Le Gallais, O.; Jouannigot-Castano, O.; Rigden, D. J.; Estay-Ahumada, C.; Hicks, D.; Sergouniotis, P. I.; Arveiler, B.; Javerzat, S.
10.1101/2025.07.10.664067 — genetics — Posted on 2025-07-11
820 Implementation and Evaluation of Support Vector Machine-Based Models for Cancer Detection Using Multi-Omic Data: A Systematic Review
Mohamadi, Z.; Abtahi, E.; Shayegh, Z. S.; Ataei Kachouei, M.; Fakhar, A.; Shirani, M. M.; Malekian, M.; Zinatshoar, A.; Biglari, M.; Rezaei, F.; ZarinKhat, A.; Mohammadi, R.
10.1101/2025.07.10.664049 — cell biology — Posted on 2025-07-11
822 Pure CD32+ CD4+ Cells Are Cytotoxic Memory CD4+ T Lymphocytes Highly Enriched for HIV-1 DNA
Adams, P.; Herrera-Carrillo, E.; Vujkovic, A.; Jongejan, A.; Moerland, P.; El Moussaoui, M.; Darcis, G.; Berkhout, B.; Pasternak, A. O.
10.1101/2025.07.09.663884 — immunology — Posted on 2025-07-11
823 Beyond Static Screens: A High-Throughput Pooled Imaging CRISPR Platform for Dynamic Phenotype Discovery
Mukherjee, S.; van Tooren, M.; Zanetti, G.; Sfakianakis, D.; Kemps, D.; Klarenbeek, J.; Kuiken, H. J.; Lieftink, C.; van den Broek, B.; Beijersbergen, R. L.; Jalink, K.
10.1101/2025.07.11.664338 — cell biology — Posted on 2025-07-11
824 Single-cell dissection of cervix and placenta reveal both novel and overlapping cell types
van Riel, M.; Lannoo, L.; Pexsters, A.; Tsuiko, O.; Parijs, I.; Claes, I.; Voet, T.; Timmerman, D.; Vermeesch, j.
10.1101/2025.07.09.663838 — cell biology — Posted on 2025-07-11
826 Is Language a Mechanical Signal? Cytoskeletal Responses to Speech in Yeast
Shirzadian, M.; Gollob, E.; Reiter, C.; Rauter, U.; Paschinger, M.; Caballero, C.; Rinnerthaler, M.; Spiess, K.
10.1101/2025.07.08.663738 — microbiology — Posted on 2025-07-11
828 FLYWCH transcription factors act in a LIN-42/Period autoregulatory loop during gonad migration in C. elegans
Kinney, B.; Menjivar-Hernandez, J.; Koitz, F.; Grinevich, D.; Madonna Baselios, M.; Hammell, C. M.; Gordon, K. L.
10.1101/2025.07.10.664215 — developmental biology — Posted on 2025-07-11
829 Conserved roles of GATA4 and its target gene TBX2 in regulation of human cardiogenesis
Graham, N.; Kirilenko, P.; Patrushev, I.; Fowler, E. D.; Kille, P.; Gilchrist, M.; Owens, N. D. L.; Latinkic, B.
10.1101/2025.07.11.664341 — developmental biology — Posted on 2025-07-11
832 STHELAR, a multi-tissue dataset linking spatial transcriptomics and histology for cell type annotation
Giraud-Sauveur, F.; Blampey, Q.; Benkirane, H.; Marinello, A.; Cournede, P.-H.; Christodoulidis, S.
10.1101/2025.07.11.664123 — cell biology — Posted on 2025-07-11
835 Regulation of the transcriptome, miRNAs, and alternative splicing in a FSGS zebrafish injury model
Mattias, F.; Tsoy, O.; Iervolino, A.; Simm, S.; Hammer, E.; Gress, A.; Lange, T.; Siegerist, F.; Ameling, S.; Kacprowski, T.; List, M.; Kalinina, O.; Franzenburg, S.; Capasso, G.; Endlich, K.; Baumbach, J.; Völker, U.; Endlich, N.; Kliewe, F.
10.1101/2025.07.09.663814 — cell biology — Posted on 2025-07-11
839 Measure Sodium Transport in Cells with NMR
Xia, J.; Yin, Y.; Chen, Y.; Wu, X.; Li, H.; Liu, Y.; He, Q.; Ji, Y.; Ma, K.; Dai, B.; Bai, H.; Yang, F.; Bai, R.; Kong, X.
10.1101/2025.07.08.663659 — cell biology — Posted on 2025-07-11
842 H2 dependent modulation of Mtr activity by small protein MtrR in Methanosarcina mazei
Habenicht, T.; Hastedt, B.; Cassidy, L.; Kiessling, C.; Tholey, A.; Schuller, J. M.; Schmitz, R. A.
10.1101/2025.05.30.657017 — microbiology — Posted on 2025-07-11
843 TAF1-dependent transcriptional dysregulation underlies multiple sclerosis
Rodriguez-Lopez, C.; Hernandez, I. H.; Terron-Bautista, J.; Agirre, E.; Pose-Utrilla, J.; Lozano-Munoz, D.; Ruiz-Blas, I.; Arroyo, A. M.; Garcia-Ortiz, I.; Lucas-Santamaria, M.; Gonzalez-Bermejo, M.; Ortega, M. C.; Machin-Diaz, I.; Chara, J. C.; Morrema, T. H. J.; Zheng, C.; Martinez, Z.; Perez-Cerda, F.; Martinez-Jimenez, M.; Sancho-Gonzalez, B.; Perez-Samartin, A.; Kabbe, M.; Casado-Barbero, M.; Santos-Galindo, M.; Borroto, A.; Alarcon, B.; Paradela, A.; De Castro, F.; Fransen, N. L.; Hoozemans, J.; Toma, C.; Matute, C.; Clemente, D.; Cortes-Ledesma, F.; Castelo-Branco, G.; Lucas, J. J.
10.1101/2024.08.23.609325 — neuroscience — Posted on 2025-07-11
845 NuMA promotes constitutive heterochromatin compaction by stabilizing linker histone H1 on chromatin
Wang, Y.; Zhao, W.; Niu, J.; Liu, C.; Wang, X.; Yuan, W.; Ai, S.; Baumeister, W.; Li, G.; He, A.; Xu, P.; Li, C.; Sun, Y.
10.1101/2025.07.08.663620 — biophysics — Posted on 2025-07-11
846 Extracellular Vesicles Mediate Glucose Regulation by GLUT4-Overexpressing Engineered Muscle Tissue in T2D Mice
Shoyhet, H.; Cohen, Y.; Bachinsky, Y. H.; Rosenhek-Goldian, I.; Kamyshinsky, R.; Hornstein, E.; Levenberg, S.
10.1101/2025.07.08.663248 — bioengineering — Posted on 2025-07-11
847 A phrenic-sparing cephalic reanastomosis model: Acute effects and implications
Lebenstein-Gumovski, M.; Zharchenko, A.; Rasueva, T.; Sobol, E.; Petrov, P.; Eskov, K.
10.1101/2025.05.06.652103 — bioengineering — Posted on 2025-07-11
849 SMCHD1 compacts DNA directly in an ATP-regulated manner
Ng, J.; Zhao, X.; Liu, X.; Soman, A.; Nordenskiöld, L.; Yan, J.; Xue, S.
10.1101/2025.07.08.663435 — molecular biology — Posted on 2025-07-11
852 Maize mutant hybrids with improved drought tolerance and increased yield in a field experimental setting
Belen, F.; Garnero Patat, P.; Jaime, C.; Walker, S.; Dellaferrera, I.; Maiztegui, J.; Dunger, G.; Dotto, M. C.
10.1101/2025.07.10.664191 — plant biology — Posted on 2025-07-11
856 Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking
Bosch, J. A.; Beltran, P. M. J.; Cavers, C.; LaGraff, J. T.; Melanson, R.; Singh, A.; Chen, W.; Hu, Y.; Tattikota, S. G.; Liu, Y.; Hashmi, Y.; Asara, J. M.; Branon, T.; Ting, A. Y.; Carr, S. A.; Perrimon, N.
10.1101/2025.07.09.659702 — genomics — Posted on 2025-07-11
858 MitoPerturb-Seq identifies common and gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmy
Burr, S. P.; Auckland, K.; Glynos, A.; Dhawanjewar, A.; Wei, W.; Ryall, C.; Hynes-Allen, A.; Prater, M.; Sczaniecka-Clift, M.; Prudent, J.; Chinnery, P. F.; van den Ameele, J.
10.1101/2025.07.08.663208 — genomics — Posted on 2025-07-11
859 Development of convolutional neural networks for automated brain-wide histopathological analysis in mouse models of synucleinopathies
Barber Janer, A.; Van Acker, E.; Vonck, E.; Plessers, D.; Rosada, F.; Van den Haute, C.; Baekelandt, V.; Peelaerts, W.
10.1101/2025.07.08.663490 — neuroscience — Posted on 2025-07-11
860 GPR17 modulates oligodendrocyte precursor cell maturation during development but has limited impact on myelin regeneration following demyelinating insults
Puorro-Radzwill, K.; Pang, P.; Giera, S.; Sheng, G.; Farley, J. E.; Garron, C.; Danthi, S.; Gans, J.; Kumar, D.; Agrawal, R.; Bangari, D. S.; Ryan, S.; Pande, N.; Samad, T. A.; Gratzer, S.; Pedraza, C.
10.1101/2025.07.08.659146 — neuroscience — Posted on 2025-07-11
861 SND3 is the membrane insertase within a fungal multipass translocon
Yang, T.-J.; Mukherjee, S.; Langer, J. D.; Hummer, G.; McDowell, M. A.
10.1101/2025.07.08.663624 — biophysics — Posted on 2025-07-11
862 AlphaGenome: advancing regulatory variant effect prediction with a unified DNA sequence model
Avsec, Z.; Latysheva, N.; Cheng, J.; Novati, G.; Taylor, K. R.; Ward, T.; Bycroft, C.; Nicolaisen, L.; Arvaniti, E.; Pan, J.; Thomas, R.; Dutordoir, V.; Perino, M.; De, S.; Karollus, A.; Gayoso, A.; Sargeant, T.; Mottram, A.; Wong, L. H.; Drotar, P.; Kosiorek, A.; Senior, A.; Tanburn, R.; Applebaum, T.; Basu, S.; Hassabis, D.; Kohli, P.
10.1101/2025.06.25.661532 — bioinformatics — Posted on 2025-07-11
863 Neural Connectome of the Ctenophore Statocyst
Jokura, K.; Jasek, S.; Niederhaus, L.; Burkhardt, P.; Jekely, G.
10.1101/2025.06.26.661250 — animal behavior and cognition — Posted on 2025-07-11
866 Targeting the 3D genome by anthracyclines for chemotherapeutic effects
Tan, M.; Sun, S.; Liu, Y.; Perreault, A. A.; Phanstiel, D. H.; Dou, L.; Pang, B.
10.1101/2024.10.15.614434 — cancer biology — Posted on 2025-07-11
869 Stabilized D2R G-protein coupled receptor oligomers identify multi-state β-arrestin complexes
Sharrocks, K. L.; Fanelli, F.; Milner, A. J.; Liu, Y.; Yining, W.; Byrne, B.; Hanyaloglu, A.
10.1101/2024.07.16.603735 — cell biology — Posted on 2025-07-11
870 AI-Driven Knowledge Synthesis for Food WebParameterisation
Spillias, S.; Fulton, E. A.; Boschetti, F.; Bulman, C.; Strzelecki, J.; Trebilco, R.
10.1101/2025.05.18.654761 — ecology — Posted on 2025-07-11
872 Wave succession in the pandemic clone of Vibrio parahaemolyticus driven by gene loss
Yang, C.; Qiu, H.; Svensson, S. L.; Ni, C.; Gao, S.; Jia, Z.; Wen, H.; Xie, L.; Xu, W.; Qin, Y.; Lin, S.; Wang, J.; Zhang, Y.; Li, Y.; Jiang, M.; Shi, X.; Hu, Q.; Zhou, Z.; Chao, Y.; Yang, R.; Cui, Y.; Martinez-Urtaza, J.; Wang, H.; Falush, D.
10.1101/2024.06.03.596356 — microbiology — Posted on 2025-07-11
873 Mafb Deficiency in Myeloid Cells Increases Susceptibility to Mycobacterium tuberculosis Infection in Mice
Hikichi, H.; Nakamura, H.; Omori, S.; Seto, S.; Hijikata, M.; Hamada, M.; Takahashi, S.; Keicho, N.
10.1101/2025.07.06.663407 — immunology — Posted on 2025-07-11
875 Thalamic Network Controllability Predicts Cognitive Impairment in Multiple Sclerosis
Yang, Y.; Woollams, A.; Lipp, I.; Zhuo, Z.; Litwinczuk, M. C.; Tomassini, V.; Liu, Y.; Trujillo-Barreto, N. J.; Muhlert, N.
10.1101/2023.11.29.568586 — neuroscience — Posted on 2025-07-11
879 ODFormer: a Virtual Organoid for Predicting Personalized Therapeutic Responses in Pancreatic Cancer
Xu, J.; Yang, X.; LI, Y.; Wang, H.; Li, Y.; Tang, S.; Guo, S.; Zou, J.; Shi, X.; Chen, Z.; Zhong, C.; Li, P.; Jing, W.; Zheng, K.; Wu, X.; Gao, D.; Chen, L.; Jin, G.
10.1101/2025.07.08.663664 — bioinformatics — Posted on 2025-07-11
881 3D Bioprinted Cell-laden GrooveNeuroTube: A Multifunctional Platform for Ex Vivo Neural Cell Migration and Growth Studies
Litowczenko, J.; Richter, Y.; Ismael, H.; Popenda, L.; Ostrowski, A.; Fiedorowicz, K.; Cabello, J. C. R.; Wychowaniec, J. K.; Tadyszak, K.
10.1101/2025.02.19.639097 — bioengineering — Posted on 2025-07-11
882 Large-scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of α-synuclein aggregation
Neupane, S.; Nikolic, L.; Maraio, L.; Goiran, T.; Karpilovsky, N.; Sellitto, S.; Bouris, V.; Yin, J.-A.; Melki, R.; Fon, E. A.; De Cecco, E.; Aguzzi, A.
10.1101/2025.06.10.658866 — neuroscience — Posted on 2025-07-11
885 Light-up nanostructures with allosteric DNA mimics of GFP
Zhang, T.; Qian, X.; Zhang, J.; Cui, H.; Bai, T.; Wang, W.; Wang, Y.; Gao, Z.; Han, D.; Zeng, W.; Wei, B.
10.1101/2025.07.10.664110 — synthetic biology — Posted on 2025-07-10
887 O-GlcNAcylation-Ubiquitin Crosstalk of METTL1 Drives m7G Epitranscriptomic Collapse and Lipid Metabolic Reprogramming in Diabetic Cardiomyopathy
Gu, X.; Meng, H.; Liu, J.; Liang, Y.; Li, B.; Wang, F.; Liu, Q.; Zhang, Z.; Liang, J.; Zhang, X.; Sun, J.; Li, J.; Liu, F.; Xiao, W.; Huang, G.; Gu, T.; Peng, S.; Huang, X.; Zhuang, R.; Zhang, J.; Li, Y.; Ye, J.; Lu, L.; Wang, X.; Yuan, F.; Ge, J.; Du, Y.
10.1101/2025.07.07.663452 — pathology — Posted on 2025-07-10
892 FishProx: Proximate conspecific interaction of Atlantic salmon (Salmo salar) for behavioural analysis through instance segmentation masks
Chen, I.-H.; Belbachir, N.; Ebbesson, L. O. E.; Munthe-Kaas, A.; Solberg, L. E.; Helberg, G. A. N.; Izquierdo-Gomez, D.; Kumaran, S. K.; Kolarevic, J.; Noble, C.
10.1101/2025.07.07.659286 — animal behavior and cognition — Posted on 2025-07-10
893 Rule-based sequences in sooty mangabey vocal communication
Le Floch, A.; Girard-Buttoz, C.; Souha Azaiez, T.; Bande, N.; Wittig, R. M.; Moran, S.; Zuberbuehler, K.; Crockford, C.
10.1101/2025.07.07.663462 — animal behavior and cognition — Posted on 2025-07-10
894 Stage- and tissue-specific gene editing using 4-OHT inducible Cas9 in whole organism
Li, Y.; Zhang, W.; Wei, Z.; Li, H.; Liu, X.; Zheng, T.; Aziz, T.; Xing, C.; Meng, A.; Wu, X.
10.1101/2025.07.07.663418 — developmental biology — Posted on 2025-07-10
895 Acinetobacter phages use distinct strategies to breach the capsule barrier
McCalla, A. J.; Walker, F. C.; Bisaro, F.; Rodriguez-Anavitate, M.; Johannesman, A.; Di Venanzio, G.; Feldman, M. F.; LeRoux, M.
10.1101/2025.07.10.664161 — microbiology — Posted on 2025-07-10
897 Twitching motility suppressors reveal a role for FimX in type IV pilus extension dynamics
Roberge, N.; Yuen, N.; Harvey, H.; Ellison, T. J.; Ellison, C. K.; Burrows, L. L.
10.1101/2025.07.10.664058 — microbiology — Posted on 2025-07-10
900 In silico design and computational characterization of novel chimeric multiepitope antigens for Mpox serosurveillance
Ghogomu, S.; Akwelle, R. N.; Shey, R. A.; Teke, M. E.; Acha, N. L.; Nchanji, G. T.; Stong, T. Y. A.; Chick, J. A.; Ntang, E. Y.; Shintouo, C. M.; Yengo, B. N.; Ayuk, A. B.; Engarimbi, J. E.; Gwei, K. Y.; Tebo, B. T.; Nebangwa, D. N.; Tamnjong, B. M.; Vanhamme, L.; Souopgui, J.; Titanji, V. P. K.
10.1101/2025.07.09.663824 — immunology — Posted on 2025-07-10
902 Astrocytic mGluR5 signaling tunes emotional and cognitive processing in the adult brain
Viana, J. F.; Dias, J. D.; Gonzalez-Arias, C.; Alves, L. S.; Veiga, A.; Abreu, D. S.; Machado, J. L.; Barsanti, S.; Pereira de Almeida, L.; Nobre, R. J.; Perea, G.; Oliveira, J. F.
10.1101/2025.07.07.663457 — neuroscience — Posted on 2025-07-10
906 Spatial tumour-immune ecosystems shape the efficacy of anti-PD1 immunotherapy in primary cutaneous melanoma
Pham, F.; Dufeu, M.; Benboubker, V.; Grimont, M.; LHORISSON, A.; Berthet, J.; Donzel, M.; Schneider, R.; Tonon, L.; Doffin, A.-C.; Boivin, F.; Durand, S.; Dubois, B.; Lopez, J.; Caux, C.; Valladeau-Guilemond, J.; Eberhardt, A.; Dalle, S.; CARAMEL, J.
10.1101/2025.07.07.661465 — cancer biology — Posted on 2025-07-10
909 Benchmarking Large Language Models for Predictive Modeling in Biomedical Research With a Focus on Reproductive Health
Sarwal, R.; Tarca, V.; Kalavros, N.; Bhatti, G.; Bhattacharya, S.; Butte, A. J.; Romero, R. J.; Stolovitzky, G.; Oskotsky, T. T.; Tarca, A. L.; Sirota, M.
10.1101/2025.07.07.663529 — bioinformatics — Posted on 2025-07-10
911 Chromosome-level assembly of the octoploid cloudberry(Rubus chamaemorus)
Strand, M. A.; To, T.-H.; Torresen, O. K.; Fullmer, S. E.; Skage, M.; Tooming-Klunderud, A.; Sandve, S. R.; Jakobsen, K. S.
10.1101/2025.07.07.663483 — genomics — Posted on 2025-07-10
912 Genetic load proxies do not predict fitness better than inbreeding does in a wild population
Robledo-Ruiz, D. A.; Sunnucks, P.; Quin, B.; Magrath, M. M. J. L.; Harley, D.; Pavlova, A.
10.1101/2025.07.07.663445 — genomics — Posted on 2025-07-10
915 Highly modular genomic architecture underlies combinatorial mechanism of speciation and adaptive radiation
Singh, P.; Tschanz-Lischer, H.; Ford, K.; Ahi, E. P.; Haesler, M.; Mwaiko, S.; Meier, J. I.; Marques, D. A.; Bruggmann, R.; Kishe, M.; Seehausen, O.
10.1101/2025.07.07.663194 — evolutionary biology — Posted on 2025-07-10
918 Targeting Aurora kinases as essential cell cycle regulators to deliver multi-stage antimalarials against Plasmodium falciparum
Langeveld, H.; Maepa, K.; Maree, M.; Thibaud, J. L.; Salomane, N.; Bridgwater, R.; Famodimu, M. T.; Godoy, L. C.; Pasaje, C. F. A.; Boonyalai, N.; de Souza, M. L.; Fong, J.; Rabie, T.; Theart, R. P.; Ghidelli-Disse, S.; Niles, J. C.; Lee, M. C. S.; Winzeler, E. A.; Delves, M. J.; Chibale, K.; Wicht, K. J.; Coulson, L. B.; Birkholtz, L.-M.
10.1101/2025.07.10.663886 — molecular biology — Posted on 2025-07-10
920 Metabolic role of the LutACB operon in Neisseria gonorrhoeae resistance to neutrophil-mediated clearance
Rawal, R.; Schmidt, J.; Schmitz, W.; Heydarian, M.; Klepsch, M.; Rudel, T.; Kozjak-Pavlovic, V.
10.1101/2025.07.10.664078 — microbiology — Posted on 2025-07-10
921 Nuclease-NTPase systems use shared molecular features to controlbacterial anti-phage defense
Ragucci, A. E.; Antine, S. P.; Leviss, E. M.; Mooney, S. E.; Garcia, J. M.; Shyrokova, L.; Hauryliuk, V.; Lee, A. S. Y.; Kranzusch, P. J.
10.1101/2025.07.10.664194 — microbiology — Posted on 2025-07-10
923 A new typing scheme demonstrates high discriminatory power for Treponema pallidum subspecies
Pla-Diaz, M.; Giacani, L.; Tantalo, L. C.; Bose, M.; Reid, T.; Marra, C.; Smajs, D.; PospIsilova, P.; Janeckova, K.; Kawahata, T.; Banno, F.; Vilfort, K.; Cao, W.; Pillay, A.; Noda, A. A.; Bosshard, P. P.; Chen, M.; Mitja, O.; Schuenemann, V.; Hackl, S. T.; Nieselt, K.; Hernandez-Bel, P.; Ocete, M. D.; Arora, N.; Gonzalez-Candelas, F.
10.1101/2025.07.10.664125 — microbiology — Posted on 2025-07-10
925 T6SS4 is heterogeneously expressed in Y. pseudotuberculosis and is a target for transcriptional and post-transcriptional regulation
Kerwien, A.; Körner, B.; Meyer, I.; Teschke, Y.; Köster, C. S.; Salto, I. P.; Dersch, P.; Herbrüggen, A.-S.
10.1101/2025.07.10.664076 — microbiology — Posted on 2025-07-10
926 Translational repression of viral RNA mediates arbovirus persistence in mosquitoes
Tallo-Parra, M.; Puig-Torrents, M.; Perez-Vilaro, G.; Ribo Pons, S.; Hernandez-Alias, X.; Mantica, F.; Irimia, M.; Serrano, L.; Diez, J.
10.1101/2025.07.10.664053 — microbiology — Posted on 2025-07-10
933 MuSHIN: A multi-way SMILES-based hypergraph inference network for metabolic model reconstruction
Zhao, Y.; Chen, Y.; Yu, Y.; Liu, X.; Du, J.; Wen, J.; Liao, C.; Sun, Q.; Wang, R.; Chen, C.
10.1101/2025.07.07.663526 — bioinformatics — Posted on 2025-07-10
938 Decoding Lymphangioleiomyomatosis (LAM) Niche Environment via Integrative Analysis of Single Cell Multiomics and Spatial Transcriptomics
Chen, K.; Zhao, S.; Guo, M.; Reza, H.; Wagner, A.; Cakar, A. C.; Jiang, C.; Zhang, E.; Green, J.; Martin, E.; Wikenheiser-Brokamp, K.; Perl, A.-K. T.; Sinner, D. I.; Yu, J. J.; Xu, Y.
10.1101/2025.07.07.663390 — genomics — Posted on 2025-07-10
939 Lipid-mediated GPR32 signaling reprograms macrophage metabolism to impair anti-tuberculous immunity
Barros, J.; Maio, M.; Ledesma, M. M.; Boix, M. E.; Faivre, N.; Monard, S.; Franco, J. L. M.; Metais, A.; Sabbione, F.; Fuentes, F.; Grosso, T. M.; Errea, A. J.; Aragone, X.; Cunto, M. S.; Palmero, D.; Matteo, M.; Ostrowski, M.; ARGUELLO, R. J.; Nanda, R.; Layre, E.; Neyrolles, O.; Verolle, C.; Lugo-Villarino, G.; Balboa, L.
10.1101/2025.07.07.663524 — immunology — Posted on 2025-07-10
940 A tumor suppressor role of the miR-15b/16-2 cluster in T-cell acute lymphoblastic leukemia
Gonzalez-Garcia, S.; Garcia-Leon, M. J.; Garcia-Peydro, M.; Fuentes, P.; Alcain, J.; Martin-Gayo, E.; Croce, C. M.; Garzon, R.; Toribio, M. L.
10.1101/2025.07.07.663472 — immunology — Posted on 2025-07-10
947 Altered lysosomal biology impairs motor neuron survival via TFEB dysregulation in spinal muscular atrophy
Rosignol, I.; Dokuzluoglu, Z.; Caldarelli, A.; Oprisoreanu, A.-M.; Ushakova, S.; Siddiqui, T.; Grover, R.; Guerlich, H.; Falkenburger, B.; Diez, S.; Grass, T.; Becker, C. G.; Rodriguez-Muela, N.
10.1101/2025.07.07.663525 — neuroscience — Posted on 2025-07-10
950 SCLC-TumorMiner: A Directly Accessible Genomics Resource for Precision Oncology: Big Data for Small Cells
Elloumi, F.; Dhall, A.; Taniyama, D.; Luna, A.; Yasuhiro, A.; Varma, S.; Wang, J.; Tehim, A.; Raffeld, M.; Aldape, K.; Redon, C.; Shresta, R.; Reinhold, W.; Aladjem, M. I.; Del Rivero, J.; Roper, N.; Thomas, A.; Pommier, Y.
10.1101/2025.07.07.663501 — cancer biology — Posted on 2025-07-10
951 AmyloGram Reveals Amyloidogenic Potential in Stroke Thrombus Proteomes
Kell, D. B.; Doyle, K. M.; Salcedo-Sora, E.; Sekhar, A.; Walker, M.; Pretorius, E.
10.1101/2025.07.07.663482 — bioinformatics — Posted on 2025-07-10
952 Innate immunocompetent iNSpheroids: A hiPSC-derived 3D model to study the central nervous system captures an early CNS response to rAAV
Gomes, C. M.; Silva, G.; Aleixo, M. M.; Simao, D.; Holtkamp, S. J.; Lobo, D. D.; Harish, P.; Jenkins, R.; Dahal, L. N.; Nobre, R. J.; Pereira de Almeida, L.; Trautwein, M.; Alves, P. M.; Brito, C.
10.1101/2025.07.07.662807 — bioengineering — Posted on 2025-07-10
953 Deciphering the altered conformational states of bifunctional thaumarchaeal crotonyl-CoA hydratase and 3-hydroxypropionyl-CoA dehydratase from Nitrosopumilus maritimus
Destan, E.; Kang, J.; Tosha, T.; Yabashi, M.; Yapici, I.; Tolar, B. B.; Kulakman, C.; Nergiz, Z.; Matsuura, H.; Kawano, Y.; Deutsch, S.; Yoshikuni, Y.; Francis, C. A.; Wakatsuki, S.; DeMirci, H.
10.1101/2025.07.07.663511 — biochemistry — Posted on 2025-07-10
954 Sex chromosome identification and genome curation, at scale, from a single individual with SCINKD
Pinto, B. J.; Gable, S. M.; Keating, S. E.; Smith, C. H.; Gamble, T.; Nielsen, S. V.; Wilson, M. A.
10.1101/2025.07.07.660342 — genomics — Posted on 2025-07-10
963 Administration of barcoded AAV capsid library to the putamen of non-human primates identifies variants with efficient retrograde transport
Dzhashiashvili, Y.; McBride, J. L.; Fabyanic, E.; Huang, X.; Kelly, B. M.; Walton-Gibbs, G. D.; Nayal, M.; Hippen, A. A.; Yu, Z.; Raman, P.; Ramsburg, E.; Davidsson, M.; Engel, E. A.; Bjorklund, T.
10.1101/2025.07.07.663544 — neuroscience — Posted on 2025-07-10
964 Calbindin Stratifies Midbrain Dopaminergic Neurons Governing Distinct Aspects of Locomotion
Bolduc, C.; Oram, C.; Donovan, S.; Bach, H.; Liu, M.; Marier, R.; Sharpe, M.; Campeau, C.; Spencer, C. D.; Martin, S. A.; Awatramani, R.; Poulin, J.-F.
10.1101/2025.07.07.663227 — neuroscience — Posted on 2025-07-10
965 Precision Functional Mapping of the Individual Human Brain Near Birth
Labonte, A. K.; Moser, J.; Camacho, M. C.; Tu, J. C.; Wheelock, M.; Laumann, T. O.; Gordon, E. M.; Fair, D. A.; Sylvester, C.
10.1101/2025.07.07.663543 — neuroscience — Posted on 2025-07-10
966 Myocyte Damage and Mass Loss Drives Increasing Water Content, Compliance, and Survival in Septic Cardiomyopathy
Ford, V. J.; Solomon, S. B.; Sun, J.; Applefeld, W. N.; Feng, J.; Wang, J.; Cortes-Puch, I.; Li, Y.; Solomon, M. A.; Safiullah, Z.; Danner, R. L.; Chen, M. Y.; Torabi-Parizi, P.; Klein, H. G.; Yu, Z.-X.; Natanson, C.
10.1101/2025.07.07.663608 — physiology — Posted on 2025-07-10
970 EED Maintains the Small Cell Lung Cancer Neuroendocrine Phenotype and Drives Lung Cancer Histological Transformation
Li, Y.; Laimon, Y. N.; Cho, H.; Vivero, M.; De Oliveira, G. R.; Delcea, A.; Savla, V.; Chen, Y.; Durmaz, Y. T.; Qiu, X.; Kukreja, S.; Li, R.; El Zarif, T.; Lu, W.; Van Orden, M.; Berchuck, J. E.; Bronson, R. T.; Li, S.; Ji, H.; Politi, K.; Freedman, M. L.; Long, H. W.; Signoretti, S.; Oser, M. G.
10.1101/2025.07.07.663486 — cancer biology — Posted on 2025-07-10
975 Direct binding of TDP-43 and Tau drives their co-condensation, but suppresses Tau fibril formation and seeding
Simonetti, F.; Zhong, W.; Hutten, S.; Uliana, F.; Schifferer, M.; Rezaei, A.; Ramirez, L. M.; Hochmair, J.; Sankar, R.; Gopalan, A.; Kielisch, F.; Riemenschneider, H.; Ruf, V.; Simons, M.; Zweckstetter, M.; Wegmann, S.; Lashley, T.; Polymenidou, M.; Edbauer, D.; Dormann, D.
10.1101/2025.07.07.662960 — biochemistry — Posted on 2025-07-10
978 Chytrid fungal infections in alpine toads proliferate during winter dormancy
Daversa, D. R.; Grasso, R.; Posta, M.; Lloyd-Smith, J. O.; Shaffer, H. B.
10.1101/2025.07.07.663599 — ecology — Posted on 2025-07-10
979 H2AK119ub Safeguards Against Ectopic Transcription Factor Mediated Gene Activation in the Developing Forebrain
Doyle, L. A.; Derrien, A.; Sengupta, D.; Unlu Bektas, F.; Lawson, J.; Pednekar, C.; von Kriegsheim, A.; Adams, I. R.; Illingworth, R. S.
10.1101/2025.07.07.663591 — molecular biology — Posted on 2025-07-10
985 Co-expression of Bovine leukemia virus and Bovine foamy virus-derived miRNAs in naturally infected cattle
Petersen, M. I.; Suarez Archilla, G.; Perez, C. V.; Gonzalez, D. D.; Trono, K. G.; Mongini, C.; Jaworski, J. P.; Carignano, H. A.
10.1101/2025.02.21.639540 — microbiology — Posted on 2025-07-10
987 Differences in immune cell profiles around the time of islet autoimmunity seroconversion in children with and without type 1 diabetes
Hohsfield, K. R.; Carry, P. M.; Slack, S. D.; Repaci, C. T.; Vanderlinden, L. A.; Kechris, K.; Rewers, M.; Norris, J. M.; Johnson, R. K.
10.1101/2025.06.23.661117 — immunology — Posted on 2025-07-10
988 Selective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity
Castillo, J. G.; Olzmann, J.; DuPage, M.; Silveria, S.; Sauquet, A.; Schirokauer, L.; Hendricks, J.; Sul, H. S.
10.1101/2025.07.06.663397 — immunology — Posted on 2025-07-10
989 Title Mafb Deficiency in Myeloid Cells Increases Susceptibility to Mycobacterium tuberculosis Infection in Mice
Hikichi, H.; Nakamura, H.; Omori, S.; Seto, S.; Hijikata, M.; Hamada, M.; Takahashi, S.; Keicho, N.
10.1101/2025.07.06.663407 — immunology — Posted on 2025-07-10
990 Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output
Marshall, J. J.; Xu, J.; Yeh, N.-H.; Yun, S.; Nomura, T.; Armstrong, J. N.; Parker, J. G.; Contractor, A.
10.1101/2023.12.20.572676 — neuroscience — Posted on 2025-07-10
994 WaveSeekerNet: Accurate Prediction of Influenza A Virus Subtypes and Host Source Using Attention-Based Deep Learning
Nguyen, H.-H.; Rudar, J.; Lesperance, N.; Vernygora, O.; Taylor, G. W.; Laing, C.; Lapen, D.; Leung, C. K.; Lung, O.
10.1101/2025.02.25.639900 — bioinformatics — Posted on 2025-07-10
996 Enhanced prediction of breast cancer patient response to chemotherapy by integrating deconvolved expression patterns of immune, stromal and tumor cells
Dhruba, S. R.; Sahni, S.; Wang, B.; Wu, D.; Rajagopal, P. S.; Schmidt, Y.; Shulman, E. D.; Sinha, S.; Sammut, S.-J.; Caldas, C.; Wang, K.; Ruppin, E.
10.1101/2024.06.14.598770 — bioinformatics — Posted on 2025-07-10
997 The open-source Masala software suite: Facilitating rapid methods development for synthetic heteropolymer design
Zaborniak, T.; Azadvari, N.; Zhu, Q.; Turzo, S. M. B. A.; Hosseinzadeh, P.; Renfrew, P. D.; Mulligan, V. K.
10.1101/2025.07.02.662756 — biochemistry — Posted on 2025-07-10
998 Gene loss associated with plasticity-first evolution in Heliconius butterflies
Pinheiro de Castro, E. C.; Cicconardi, F.; Warren, I. A.; Rueda-M, N.; Salazar, C.; Bak, S.; Montgomery, S. H.; Jiggins, C. D.
10.1101/2025.06.22.660914 — evolutionary biology — Posted on 2025-07-10
1000 PILS-Nir1 is a novel phosphatidic acid biosensor that reveals mechanisms of lipid production
Weckerly, C. C.; Rahn, T. A.; Ehrlich, M.; Wills, R. C.; Pemberton, J. G.; Airola, M. V.; Hammond, G. R.
10.1101/2024.02.28.582557 — cell biology — Posted on 2025-07-10
1001 Orderly mitosis shapes interphase genome organization
Guin, K.; Keikhosravi, A.; Chari, R.; Pegoraro, G.; Misteli, T.
10.1101/2025.06.03.657645 — cell biology — Posted on 2025-07-10
1003 Protective efficacy of mutant strains of Borrelia burgdorferi as potential reservoir host-targeted biologics against Lyme disease
Kumaresan, V.; Smith, T.; Lumbreras, M.; MacMackin-Ingle, T.; Kilgore, N.; Starling-Lin, J.; Horn, E. J.; Seshu, J.
10.1101/2025.07.09.663885 — microbiology — Posted on 2025-07-10
1004 Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegeneration
Buck, S. A.; Rubin, S. A.; Kunkhyen, T.; Treiber, C. D.; Xue, X.; Fenno, L. E.; Mabry, S. J.; Sundar, V. R.; Yang, Z.; Shah, D.; Ketchesin, K. D.; Becker-Krail, D. D.; Vasylieva, I.; Smith, M. C.; Weisel, F. J.; Wang, W.; Erickson-Oberg, M. Q.; O'Leary, E. I.; Aravind, E.; Ramakrishnan, C.; Kim, Y. S.; Wu, Y.; Quick, M.; Coleman, J. A.; MacDonald, W. A.; Elbakri, R.; Olsen, A. L.; Rocha, E. M.; Miller, G. W.; De Miranda, B. R.; Palladino, M. J.; McCabe, B. D.; Fish, K. N.; Seney, M. L.; Rayport, S.; Mingote, S.; Deisseroth, K.; Hnasko, T. S.; Awatramani, R.; Watson, A. M.; Waddell, S.; Cheetha
10.1101/2023.10.02.560584 — neuroscience — Posted on 2025-07-10
1005 Sensory responses of visual cortical neurons are not prediction errors
Westerberg, J. A.; Xiong, Y. S.; Sennesh, E.; Nejat, H.; Ricci, D.; Durand, S.; Hardcastle, B.; Cabasco, H.; Belski, H.; Bawany, A.; Gillis, R.; Loeffler, H.; Peene, C. R.; Han, W.; Nguyen, K.; Ha, V.; Johnson, T.; Grasso, C.; Young, A.; Swapp, J.; Ouellette, B.; Caldejon, S.; Williford, A.; Groblewski, P. A.; Olsen, S. R.; Kiselycznyk, C.; Koch, C.; Lecoq, J. A.; Maier, A.; Bastos, A. M.
10.1101/2024.10.02.616378 — neuroscience — Posted on 2025-07-10
1006 Time-resolved functional connectivity during visuomotor graph learning
Loman, S.; Caciagli, L.; Patankar, S. P.; Kahn, A. E.; Szymula, K. P.; Nyema, N.; Bassett, D. S.
10.1101/2024.07.04.602005 — neuroscience — Posted on 2025-07-10
1010 Wnt signaling promotes inflammation and EMT-associated gene expression in mesenchymal TNBC
Garcia-Areas, R.; Girard, E.; Lasla, H.; Raynal, V.; Pandey, A. K.; Servant, N.; Jezequel, P.; Dubois, T.
10.1101/2025.07.04.663027 — bioinformatics — Posted on 2025-07-10
1011 Emergence of tipping points and transient dynamics in finite observations
Cobo-Lopez, S.; Carbajal, L. J.; Witt, M.; Rohwer, F. L.; Luque, A.
10.1101/2023.12.27.573307 — ecology — Posted on 2025-07-10
1013 Metabolic Adaptations of Prostate Cancer Cells Under Chronic Fructose Stimulation
Echeverria, C. E.; Oyarzun, V. I.; Jara, C.; Flores-Faundez, E.; Ramirez, C.; Torres-Estay, V.; Tapia-Rojas, C.; Diaz, J.; Meneses, M.; Cancino, J.; Pinilla, A.; San Martin, A.; Rosario, S.; Godoy, A. S.
10.1101/2025.07.07.663510 — cell biology — Posted on 2025-07-10
1016 A naturally occurring urinary collagen type I alpha 1-derived peptide inhibits collagen type I-induced endothelial cell migration at physiological concentrations
Devos, H.; Mina, I. K.; Paradeisi, F.; Makridakis, M.; Tserga, A.; Mokou, M.; Zoidakis, J.; Mischak, H.; Vlahou, A.; Latosinska, A.; Roubelakis, M. G.
10.1101/2025.07.08.663687 — cell biology — Posted on 2025-07-10
1017 Structural remodeling of target-SNARE protein complexes by NSF enables synaptic transmission
White, K. I.; Khan, Y. A.; Qiu, K.; Balaji, A.; Couoh-Cardel, S.; Esquivies, L.; Pfuetzner, R. A.; Diao, J.; Brunger, A. T.
10.1101/2024.10.11.617886 — neuroscience — Posted on 2025-07-10
1021 Fetal reversion from diverse lineages sustains the intestinal stem cell pool and confers stress resilience
Kirino, S.; Uefune, F.; Miyake, K.; Ogasawara, N.; Kobayashi, S.; Watanabe, S.; Hiraguri, Y.; Ito, G.; Akahoshi, K.; Ban, D.; ES, J. v.; Clevers, H.; Watanabe, M.; Okamoto, R.; Yui, S.
10.1101/2025.07.08.663108 — cell biology — Posted on 2025-07-10
1022 Identification of transporters essential for survival of Leishmania promastigotes in the digestive tract of sand flies
Sadlova, J.; Vojtkova, B.; Becvar, T.; Dobramysl, U.; Moeri, S.; Alagoez, C.; Wheeler, R. J.; Volf, P.; Gluenz, E.; Albuquerque-Wendt, A.
10.1101/2025.07.07.663555 — cell biology — Posted on 2025-07-10
1026 Transcutaneous auricular vagus nerve stimulation during movement modulates motor neural circuitry without widespread cortical or autonomic activation
Perrin, C.; Pallotti, F.; Weilenmann, T.; Lhoste, C.; Potok-Szybinska, W.; Zhang, X.; Wenderoth, N.; Lambercy, O.; Donegan, D.; Viskaitis, P.
10.1101/2025.07.07.663419 — neuroscience — Posted on 2025-07-10
1029 Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2
Chen, S.; Basiashvili, T.; Hutchings, J.; Murillo, M. S.; Suarez, A. V.; Xiong, E.; Louro, J. A.; Leschziner, A. E.; Villa, E.
10.1101/2024.06.18.599606 — biophysics — Posted on 2025-07-10
1032 Fifteenth century CE Bolivian maize reveals genetic affinities with ancient Peruvian maize
Chen, H.; Baetsen-Young, A.; Thompson, A.; Day, B.; Madzima, T.; Wasef, S.; Rivera Casanovas, C.; Lovis, W.; Wrobel, G.
10.1101/2025.03.31.646424 — plant biology — Posted on 2025-07-10
1036 First Comprehensive Examination of the Molecular Phylogenetics of Saki Monkeys, Genus Pithecia Desmarest, 1804, Reveals an Unexpectedly Low Taxonomic Diversity
Boubli, J. P.; Silva, F. E.; Senna, P. S.; Batista, R.; Costa-Araujo, R.; Miranda, C.; Rossi, R.; Gordo, M.; Badrock, P.; Mittermeier, R.; Valsechi, J.; Silva, M. N. F.; Messias, M.; van Heteren, A. H.; Rossi, C.; Figueiredo, W.; Rylands, A. B.; Hrbek, T.; Farias, I. P.
10.1101/2025.07.06.663372 — zoology — Posted on 2025-07-10
1040 Resorbable Poly-(D,L)-Lactide Anchorage of Nanoparticulate Mineralized Collagen Materials Maximizes In Vivo Skull Regeneration
Bedar, M.; Ren, X.; Chen, W.; Kang, Y.; Moghadam, S.; Huang, K. X.; Shariati, K.; Harley, B. A. C.; Lee, J. C.
10.1101/2025.07.06.663409 — bioengineering — Posted on 2025-07-10
1041 Modular Assembly of Biohybrid Machines Using Force-Enhanced Skeletal Muscle Actuators
Yang, H.; Williamson, A. S.; Seok, J. M.; Ranke, D.; McGee, D.; Trotto, E.; Chin, K.; Patel, D. K.; Feinberg, A. W.; Cohen-Karni, T.; Webster-Wood, V.
10.1101/2025.07.06.663299 — bioengineering — Posted on 2025-07-10
1044 BrainBeacon: A Cross-Species Foundation Model for Single-cell Resolved Brain Spatial Transcriptomics
Zhang, C.; Yang, Y.; Jiao, Y.; Yang, Q.; Guo, X.; Xu, J.; Li, J.; Zhou, Y.; Liu, Z.; Wu, Y.; Zhang, Y.; Jiang, C.; Ma, J.; Liu, Y.; Zhang, Y.; Xiao, K.; Sun, Y.; Liu, C.; Han, L.; Qi, Y.; Aihara, K.; Li, C.; Cheng, Y.; Chen, L.; Wei, W.
10.1101/2025.07.08.663729 — bioinformatics — Posted on 2025-07-10
1045 MHC-IIB disassortative mate choice in a genetically monogamous seabird
Thel, L.; Pineaux, M.; Ribeiro, L.; Danchin, E.; Whelan, S.; Hatch, S. A.; Blanchard, P.; Leclaire, S.
10.1101/2024.12.19.629314 — animal behavior and cognition — Posted on 2025-07-10
1046 Gene model for the ortholog of Glys in Drosophila ananassae
Gruys, M. L.; Myers, A. R.; Kiser, C. A.; Laskowski, L. F.; Richardson, A. M.; Romo, I.; Youngblom, J. J.; Rele, C. P.; Reed, L. K.
10.1101/2025.07.09.662856 — genomics — Posted on 2025-07-10
1048 A Novel FNDC1-NAMPT-NAD axis is Implicated in Small and Large-vessel Arterial Disease and Drives Vascular Calcification
Lee, S.; Guo, Y.; Kajuluri, L. P.; Roh, K.; Singh, K.; Jiang, W.; Moore, E.; Tattersfield, H.; Ostrom, K.; Birchenough, C.; Johnson, A. L.; Krinsky, S.; Bouchouari, H.; Mahamdeh, M.; Lee, L. Y.; Wyant, G.; Rich, S. S. S.; Rotter, J. I. I.; Taylor, K. D.; Malik, S.; Gerszten, R. E.; Cruz, D. E.; Tracy, R. P.; Wu, H.; Zhang, H.; Lu, H.; Kavousi, M.; Shanahan, C. M.; Duer, M. J.; Kramann, R.; Nazarian, R. M.; Eagleton, M. J.; Chen, Y.; Miller, C. L.; Nigwekar, S. U.; Malhotra, R.
10.1101/2025.07.08.663801 — cell biology — Posted on 2025-07-10
1049 Matrix-associated extracellular vesicles modulate smooth muscle cell adhesion and directionality by presenting collagen VI.
Kapustin, A. N.; Tsakali, S. S.; Whitehead, M.; Chennell, G.; Wu, M.-Y.; Molenaar, C.; Kutikhin, A.; Chen, Y.; Ahmad, S.; Bogdanov, L.; Sinitsky, M.; Rubina, K.; Clayton, A.; Verweij, F. J.; Pegtel, D. M.; Zingaro, S.; Lobov, A.; Zainullina, B.; Owen, D.; Parsons, M.; Cheney, R. E.; Warren, D.; Humphries, M. J.; Iskratsch, T.; Holt, M.; Shanahan, C. M.
10.1101/2023.08.17.551257 — cell biology — Posted on 2025-07-10
1051 Causal disconnectomics of motion perception: insights from TMS-induced BOLD responses
Raffin, E.; Salamanca-Giron, R. F.; Huxlin, K. R.; Reynaud, O.; Mattera, L.; Martuzzi, R.; Hummel, F.
10.1101/2022.03.03.482512 — neuroscience — Posted on 2025-07-10
1054 Avoidance engages dopaminergic punishment in Drosophila
Amin, F.; Stone, J. T.; Koenig, C.; Mancini, N.; Murakami, K.; Bidaye, S. S.; Heim, M.-M.; Owald, D.; Majumder, U.; Grunwald Kadow, I. C.; Pierzchlinska, A.; Litwin-Kumar, A.; Barnstedt, O.; Gerber, B.
10.1101/2025.07.07.663268 — neuroscience — Posted on 2025-07-10
1055 HER2; p53 Co-mutated Cancers Show Increased Histone Acetylation and are Sensitive to Neratinib plus Trastuzumab Deruxtecan.
Cheng, X.; Hsia, J.; Iraheta, J.; Gongora, J.; Highkin, M.; Jin, X.; Guo, Z.; Prior, J. L.; Edwards, J. R.; Li, S.; Hagemann, I. S.; Ma, C. X.; Lin, Z.; Garcia, B. A.; Bose, R.
10.1101/2025.07.06.663368 — cancer biology — Posted on 2025-07-10
1058 Why they occur here but not there - a case study of Great Spotted Woodpeckers in the city of Munich
Weisser, W. W.; Fairbairn, A.; Muehlbauer, M.; Guthmann, L.; Arndt, A.; Bauer, Y.; Caravitis, L.; Fischer, F.; Herre, V.; Kaucher, J.; Klein, K.; Kleinschroth, I.; Niederlechner, S.; Peters, I.; Schwering, L.; Zeller, A.; Meyer, S. T.
10.1101/2025.07.06.663361 — ecology — Posted on 2025-07-10
1060 APEX2 proximity labeling of RNA in bacteria
Yassine, H.; Sirotkin, E.; Goldberger, O.; Lawal, V.; Kearns, D. B.; Schrader, J. M.
10.1101/2024.09.18.612050 — microbiology — Posted on 2025-07-10
1063 Acinar-Derived VEGF-A Orchestrates Blood Vascular Remodeling and Preserves Microvessels During Acute Pancreatitis
Aajja, E.; Lefort, H.; Mahibullah, S.; Frederic, D.; Vandooren, L.; Henriet, P.; Tyteca, D.; Pierreux, C. E.
10.1101/2025.07.06.663280 — pathology — Posted on 2025-07-10
1065 Population genomics reveals an ancient origin of heartworms in canids
Power, R. I.; Abdullah, S.; Walden, H. S.; Verocai, G. G.; Sanders, T. L.; Luksovsky, J. L.; Moorhead, A. R.; Dzimianski, M. T.; Foster, J. M.; Michalski, M. L. L.; Rojas, A.; Chacon, S. C.; Deak, G.; Mihalca, A. D.; Danesi, P.; Papadopoulos, E.; Taweethavonsawat, P.; Thi Buip, D.; Do Ngoc, A.; Sharma, R. S. K.; Ho, S. Y. W.; Doyle, S. R.; Slapeta, J.
10.1101/2024.12.26.630432 — evolutionary biology — Posted on 2025-07-10
1067 Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression
Li, T.; Lu, L.; Qiu, J.; Dong, X.; Yang, L.; He, K.; Gu, Y.; Zhou, B.; Jia, T.; Lawrence, T.; Malissen, M.; Wang, G.; Huang, R.; Wang, H.; Malissen, B.; Liang, Y.; Zhang, L.
10.1101/2025.05.23.655779 — immunology — Posted on 2025-07-10
1069 Behavioural separation of face memory and face perception
Kadlec, J.; Walsh, C. R.; Wilf, M.; Rissman, J.; Ramot, M.
10.1101/2025.02.17.638018 — neuroscience — Posted on 2025-07-10
1070 Shared and individual tuning curves for social vision
Varrier, R. S.; Su, Z.; Liang, Q.; Benson, T. G.; Jolly, E.; Finn, E. S.
10.1101/2025.01.19.633772 — neuroscience — Posted on 2025-07-10
1071 Target engagement studies and kinetic live-cell degradation assays enable the systematic characterization of HDAC6 PROTACs
Hanl, M.; Feller, F.; Honin, I.; Tan, K.; Miranda, M.; Schaeker-Huebner, L.; Bueckreiss, N.; Schiedel, M.; Guetschow, M.; Bendas, G.; Hansen, F. K.
10.1101/2025.03.31.646177 — pharmacology and toxicology — Posted on 2025-07-10
1074 Depletion of endomembrane reservoirs drives phagocytic appetite exhaustion in macrophages
Fountain, A.; Mansat, M.; Lackraj, T.; Gimenez, M. C.; Moussaoui, S.; Ezzo, M.; Soffiaturo, S.; Urdaneta, E.; Verdawala, M. B.; Fung, K.; Lancaster, C.; Somerville, E.; Hinz, B.; Terebiznik, M.; Botelho, R. J.
10.1101/2024.07.31.605905 — cell biology — Posted on 2025-07-10
1075 Compost bacteria as a promising new solution for degradation of diclofenac and related pharmaceuticals for water treatment processes
Demaria, F.; Blattner, R.; Puorger, C.; Kolvenbach, B.; Cretoiu, M. S.; Corvini, P.; Lipps, G.; Suleiman, M.
10.1101/2025.07.09.663875 — microbiology — Posted on 2025-07-10
1077 Reconstructing Voice Identity from Noninvasive Auditory Cortex Recordings
Lamothe, C.; Thoret, E.; Trapeau, R.; Giordano, B. L.; Sein, J.; Takerkart, S.; Ayache, S.; Artieres, T.; Belin, P.
10.1101/2024.02.27.582302 — neuroscience — Posted on 2025-07-10
1080 Predicting cellular responses to perturbation across diverse contexts with STATE
Adduri, A. K.; Gautam, D.; Bevilacqua, B.; Imran, A.; Shah, R.; Naghipourfar, M.; Teyssier, N.; Ilango, R.; Nagaraj, S.; Ricci-Tam, C.; Carpenter, C.; Subramanyam, V.; Winters, A.; Dong, M.; Tirukkovalur, S.; Sullivan, J.; Plosky, B. S.; Eraslan, B.; Youngblut, N. D.; Leskovec, J.; Gilbert, L. A.; Konermann, S.; Hsu, P. D.; Dobin, A.; Burke, D. P.; Goodarzi, H.; Roohani, Y. H.
10.1101/2025.06.26.661135 — systems biology — Posted on 2025-07-10
1081 Reversible and reusable compartmentalized microfluidic chip for coculture of dorsal root ganglion neurons
Moreau, S.; Berdines, R. F.; El Jalkh, T.; Simon, A.; Taret, G.; Fomina, A.; Becker, C.; Estevez-Torres, A.; Bernard, S.; Salmon, H.
10.1101/2024.12.10.627139 — biophysics — Posted on 2025-07-10
1082 MOTL: enhancing multi-omics matrix factorization with transfer learning
Hirst, D.; Terezol, M.; Cantini, L.; Villoutreix, P.; Vignes, M.; Baudot, A.
10.1101/2024.03.22.586210 — bioinformatics — Posted on 2025-07-10
1083 APOBEC3A, not APOBEC3B, drives deaminase mutagenesis in human gastric epithelium
An, Y.; Lee, J.-H.; Lim, J.; Youk, J.; Park, S.; Park, J.-H.; Yi, K.; Kim, T.; Nam, C. H.; Lee, W. H.; Oh, S. A.; Bae, Y. J.; Lee, J.; Park, J. W.; Kim, J.-H.; Kim, H.; Snippert, H.; Koo, B.-K.; Ju, Y. S.
10.1101/2024.10.28.620744 — genomics — Posted on 2025-07-10
1084 Multi-omics discovery of hallmark protein and lipid features of circulating small extracellular vesicles in humans
Rai, A.; Huynh, K.; Poh, Q. H.; Fang, H.; Claridge, B.; Cross, J.; Duong, T.; Duarte, C.; Shaw, J.; Marwick, T.; Meikle, P.; Greening, D. W.
10.1101/2024.03.16.585131 — cell biology — Posted on 2025-07-10
1085 Targeted degradation of GSPT1 and NEK7 by a molecular glue prodrug for treatment of HCC
Glaza, P.; Pluta, R.; Odrzywoł, K. E.; Klejnot, M.; Wieczorek, M.; Cottens, S.; Coppen, D.; Dobrzanski, P.; Drmota, T.; Lis-Grzesniak, J.; Sniezewska, A.; Majkut, J.; Mianowska, M.; Rozborska, P.; Jarmuszkiewicz, M.; Kaczanowska, K.; Adamska, A.; Takagi, T.; Sawicka, A.; Serwotka-Suszczak, A.; Makowska, O.; Gajewska, D.; Jurczak, K.; Leszkowicz, K.; Mankiewicz, M.; Przytulski, K.; Wisniewski, J.; Szlachcic, A.; Walczak, M. J.
10.1101/2025.06.25.661504 — molecular biology — Posted on 2025-07-10
1087 Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression
Li, T.; Lu, L.; Qiu, J.; Dong, X.; Yang, L.; He, K.; Gu, Y.; Zhou, B.; Jia, T.; Lawrence, T.; Malissen, M.; Wang, G.; Huang, R.; Wang, H.; Malissen, B.; Liang, Y.; Zhang, L.
10.1101/2025.05.23.655779 — immunology — Posted on 2025-07-10
1089 Executive Resources Shape the Impact of Language Predictability Across the Adult Lifespan
Schuckart, M. M.; Martin, S.; Tune, S.; Schmitt, L.-M.; Hartwigsen, G.; Obleser, J.
10.1101/2024.05.08.592872 — neuroscience — Posted on 2025-07-10
1090 Astrocytic modulation of population encoding in mouse visual cortex via GABA transporter 3 revealed by multiplexed CRISPR/Cas9 gene editing
Park, J.; Sipe, G. O.; Tang, X.; Ojha, P.; Fernandes, G.; Leow, Y. N.; Zhang, C.; Osako, Y.; Natesan, A.; Drummond, G. T.; Jaenisch, R.; Sur, M.
10.1101/2024.11.06.622321 — neuroscience — Posted on 2025-07-10
1098 Changes in gene expression in eukaryotic phytoplankton at the Atlantic-Arctic polar front
Fremont, P.; Pelletier, E.; Da Silva, C.; Oziel, L.; Campese, L.; Villar, E.; Vannier, T.; Rastogi, A.; Aury, J.-M.; Karp-Boss, L.; Babin, M.; Wincker, P.; Bowler, C.; Gehlen, M.; Iudicone, D.; Jaillon, O.
10.1101/2022.11.01.514737 — genomics — Posted on 2025-07-10
1099 Flexible foraging effort shapes Adelie penguin reproductive success across Antarctica and sea ice conditions
Barracho, T.; Bardon, G.; Houstin, A.; Beaulieu, M.; Blanchard, P.; Cristofari, R.; Lenourry, L.; Raclot, T.; Tabillon, C.; Zitterbart, D.; Lecomte, N.; Le Bohec, C.
10.1101/2025.07.05.663228 — ecology — Posted on 2025-07-10
1100 Leveraging Light Detection and Ranging (LiDAR) to Elucidate Forest Structural Conditions that Influence Eastern Whip-poor-will Abundance
Larkin, J. T.; Itter, M. S.; Fiss, C. J.; Chronister, L. M.; Kitzes, J.; Larkin, J. L.; Larkin, H. P.; McNeil, D. J.; D'Amato, A. W.; Akresh, M. E.; King, D. I.
10.1101/2025.06.26.661842 — ecology — Posted on 2025-07-10
1102 Influence of the broadly neutralizing antibody VRC01 on HIV breakthrough virus populations in antibody-mediated prevention trials
Williamson, C.; Moodley, C.; Magaret, C. A.; Giorgi, E. E.; Rolland, M.; Westfall, D. H.; Yssel, A.; Deng, W.; Rossenkhan, R.; Mkhize, N. N.; Chen, L. H.; Zhao, H.; Bhattacharya, T.; Pankow, A.; Murrell, B.; York, T.; Gwashu-Nyangiwe, A.; Ndabambi, N.; Thebus, R.; Cohen, P.; Lambson, B. E.; Kaldine, H.; Bhebhe, S.; Juraska, M.; Bai, H.; deCamp, A. C.; Miner, M.; Ludwig, J.; Molitor, C.; Beaume, N.; Matten, D.; Huang, Y.; Zhang, L.; Reeves, D. B.; Mayer, B.; Karuna, S. T.; Hural, J. A.; Morris, L.; Montefiori, D.; Bumgarner, R. E.; Moore, P.; Edlefsen, P. T.; Edupuganti, S.; Mgodi, N.; McElrath
10.1101/2025.07.01.659979 — molecular biology — Posted on 2025-07-10
1104 Recon8D: A metabolic regulome network from oct-omics and machine learning
Schildcrout, R.; Smith, K.; Bhowmick, R.; Lu, Y.; Menon, S.; Kapadia, M.; Kurtz, E.; Coffeen-Vandeven, A.; Nelakuditi, S.; Chandrasekaran, S.
10.1101/2024.08.17.608400 — systems biology — Posted on 2025-07-10
1105 Clinical and molecular characterisation of primary refractoriness to atezolizumab plus bevacizumab in patients with unresectable hepatocellular carcinoma.
Lombardi, P.; Ramon-Gil, E.; Brunetti, L.; Manfredi, G. F.; Merces, G.; Fulgenzi, C. A. M.; DAlessio, A.; Torkpour, A.; Celsa, C.; Stefanini, B.; Yang, H.; Crowley, F.; Marron, T. U.; Saeed, A.; Pinter, M.; Scheiner, B.; Huang, Y.-H.; Lee, P.-C.; Nishida, N.; Po-Ting Lin, R.; Dalbeni, A.; Vivaldi, C.; Masi, G.; Rohlen, N.; von Felden, J.; Kaseb, A.; Galle, P. R.; Kudo, M.; Hsu, W.-F.; Rimassa, L.; Parisi, A.; Kelley, R. K.; Toyoda, H.; Pirisi, M.; Jabar, R. F.; Rakaee, M.; Cabibbo, G.; Camma, C.; Piscaglia, F.; Hwang, S.; Shin, D. J.; Li, M.; Daniele, G.; Mann, D.; Chon, H. J.; Leslie, J.; Pin
10.1101/2025.07.08.663653 — cancer biology — Posted on 2025-07-10
1106 ODFormer: a Virtual Organoid for Predicting Personalized Therapeutic Responses in Pancreatic Cancer
Xu, J.; Yang, X.; LI, Y.; Wang, H.; Li, Y.; Tang, S.; Guo, S.; Zou, J.; Shi, X.; Chen, Z.; Zhong, C.; Li, P.; Jing, W.; Zheng, K.; Wu, X.; Gao, D.; Chen, L.; Jin, G.
10.1101/2025.07.08.663664 — bioinformatics — Posted on 2025-07-10
1109 Integrated metagenome-resolved profiling of the resistome, virulome, and mobilome in the gut microbiota of wild birds
Su, J.; Gao, Y.-Q.; Elsheikha, H. M.; Lei, C.-C.; Xie, H.-L.; Nan, F.-L.; Ma, H.; Yang, M.-T.; Wang, H.-T.; Ni, H.-B.; Sun, H.-T.; Hongchao, S.; Zhang, X.-X.
10.1101/2025.07.09.663844 — microbiology — Posted on 2025-07-09
1110 Nonsense-mediated decay masks cryptic splicing events caused by TDP-43 loss
Zeng, Y.; Sianto, O.; Lovchykova, A.; Liu, C.; Akiyama, T.; Petrucelli, L.; Gitler, A. D.
10.1101/2025.07.09.664014 — neuroscience — Posted on 2025-07-09
1111 5-hydroxymethylcytosine deposition mediates Polycomb Repressive Complex 2 function in MYCN-amplified neuroblastoma
Chennakesavalu, M.; Lopez, G. L.; Gupta, V.; Moore, K.; Xue, Y.; Majowka, J.; Veeravalli, S.; Borchert, R.; Pomaville, M.; Chlenski, A.; He, C.; Piunti, A.; Applebaum, M.
10.1101/2025.07.05.663256 — cancer biology — Posted on 2025-07-09
1112 A microfluidic model to recapitulate pH and oxygen gradients in solid tumors
Li, Y.-F.; Dos Santos, L.; Chara, M. R.; Auxillos, J.; Sandelin, A.; Pedersen, S. F.; Marie, R.
10.1101/2025.07.05.663284 — cancer biology — Posted on 2025-07-09
1114 PromptBio: A Multi-Agent AI Platform for Bioinformatics Data Analysis
Yang, X.; Shashidhar, K.; Zhang, M.; Gu, W.; Han, B.; Guo, V.; Zheng, J.; Lin, X.; Addoni, C.; Zheng, Y.; Chen, J.; Li, K.; Wang, J.; Yu, L.; Wu, L.; Shi, S.; Wang, W.; Leng, Y.; Ma, Y.
10.1101/2025.07.05.663295 — bioinformatics — Posted on 2025-07-09
1118 Chemical clues to infection: Metabolome differentiation underlies host colonization of potential biocontrol agents from the entomopathogenic genus Cordyceps
Charria Giron, E.; Toshe, R.; Khonsanit, A.; Kobmoo, N.; Kwanthong, P.; Gorelik, T. E.; Luangsa-ard, J. J.; Ebada, S. S.; Stadler, M.
10.1101/2025.07.06.659992 — ecology — Posted on 2025-07-09
1120 Compost bacteria as a promising new solution for degradation of diclofenac and related pharmaceuticals for water treatment processes
Suleiman, M.; Demaria, F.; Blattner, R.; Puorger, C.; Kolvenbach, B.; Cretoiu, M. S.; Corvini, P.; Lipps, G.
10.1101/2025.07.09.663875 — microbiology — Posted on 2025-07-09
1121 A Fitness Entropy Compensation effect set the trade-off between growth and gene expression in cell populations
Delvenne, M.; Vandenbroucke, V.; Henrion, L.; Sehrt, M.; Martinez, J. A.; Sloodts, A.; Telek, S.; Zicler, A.; Delvigne, F.
10.1101/2025.07.05.663304 — systems biology — Posted on 2025-07-09
1122 A coupled fluorescence assay for high-throughput screening of polyurethane-degrading enzymes
yang, l.; DENG, X.; LIU, R.; LI, J.; ZHAI, J.; MA, X.; LIN, A. K. L.; SHAO, Z.; LU, H.
10.1101/2025.07.09.663332 — synthetic biology — Posted on 2025-07-09
1123 Derivation of cardiomyocyte-propelled motile aggregates from stem cells
Ho, C.; Glykofrydis, F.; Godage, G.; Poon, K.; Kunnan, M.; Swedlund, B.; Murillo, S.; Morsut, L.
10.1101/2025.07.09.663178 — synthetic biology — Posted on 2025-07-09
1125 Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model
Urbaniak, A. J.; Heflin, B.; Siegel, E.; Reed, M.; Nix, J. S.; Yee, E. U.; Jedrzejczyk, M.; Klejborowska, G.; Stepczynska, N.; Huczynski, A.; Nagalo, M. B.; Chambers, T. C.; Post, S.; Eoff, R. L.; MacNicol, M. C.; Tiwari, A.; Kelly, T.; Tackett, A. J.; MacNicol, A. M.
10.1101/2025.07.05.663311 — pharmacology and toxicology — Posted on 2025-07-09
1126 The effect of PEGylation on surface tethering of liposomes via DNA nanotechnology.
Gaston, J.; Meepat, S.; Islam, M. S.; Daljit Singh, J. K.; Booth, M. J.; Wickham, S. F. J.; Baker, M. A.
10.1101/2025.07.07.663613 — biophysics — Posted on 2025-07-09
1132 Revalidation of Manis aurita, based on integrative morphological and genomic evidence
Koju, N. P. P.; Zeng, Z.; Zhang, G.; Huang, X.; Yao, Z.; Wang, X.; Hawkins, M. T. R.; Hinckley, A.; Flores, M. F. C.; Guo, C.; Li, J.; Maharjan, D.; Huang, L.; Yu, W.; Leng, L.; He, K.; Feijo, A.; Hua, Y.
10.1101/2025.07.05.663294 — evolutionary biology — Posted on 2025-07-09
1133 Interdisciplinary Study on Drug-Induced-Phospholipidosis of Repurposing Libraries through Machine Learning and Experimental Evaluation in Different Cell Lines
Kuzikov, M.; Kalman, A.; Reinshagen, J.; Huchting, J.; Qian, K.; Axelsson, H.; Oestling, P.; Seashore-Ludlow, B.; Gadiya, Y.; Gribbon, P.; Zaliani, A.
10.1101/2025.07.08.663638 — molecular biology — Posted on 2025-07-09
1134 Morphological plasticity of endophytic Chitinophaga pinensis
Liedtke, J.; Rodenburg, F.; Du, C.; Zhang, L.; van Wezel, G.; Briegel, A.
10.1101/2025.07.09.663833 — microbiology — Posted on 2025-07-09
1135 Metagenomic analysis of antimicrobial resistance, virulence, and mobile genetic elements in the gut microbiota of Caprinae species
Su, J.; Elsheikha, H. M.; Guo, L.; Liu, R.; Shang, K.-M.; Yu, H.-L.; Ma, H.; Ni, H.-B.; Chen, B.-N.; Zhang, X.-X.; Yang, X.
10.1101/2025.07.09.663846 — microbiology — Posted on 2025-07-09
1136 An orally available PfPKG inhibitor blocks sporozoite infection of the liver
BHANOT, P.; Dhiyebi, H.; Mbaye, A.; Thaniana, A.; Gilleran, J.; Eck, T.; Ashraf, K.; Fan, H.; Seibold, S.; Battaile, K.; Siekierka, J.; Johnson, E.; Roth, A.; De Rocher, A.; Lovell, S.; Miller, E.; Roberge, J. Y.
10.1101/2025.07.09.663303 — microbiology — Posted on 2025-07-09
1137 Multi-omics characterization of the skin microbiota reveals the anti-aging roles of Stenotrophomonas maltophilia
Guo, D.; Chen, Y.; Wu, Y.; Cheng, J.; Lai, W.; Ma, W.; Yang, H.; Han, L.; Ma, L.; Jia, H.; Liu, X.
10.1101/2025.07.09.663908 — microbiology — Posted on 2025-07-09
1138 Simple sequence repeats power Staphylococcus aureus adaptation
Guerillot, R.; Hayes, A.; Hachani, A.; Giulieri, S. G.; Donovan, L.; Judd, L. M.; Sharkey, L. K.; Goncalves da Silva, A.; Seemann, T.; Stinear, T. P.; Howden, B. P.
10.1101/2025.07.08.663602 — microbiology — Posted on 2025-07-09
1140 Activating and inhibiting nucleotide signals coordinate bacterial anti-phage defense
Yamaguchi, S.; Fernandez, S. G.; Wassarman, D. R.; Luders, M.; Schwede, F.; Kranzusch, P. J.
10.1101/2025.07.09.663793 — microbiology — Posted on 2025-07-09
1141 A developmental program of early residency promotes the differentiation of divergent uterine NK cell subsets in humans
Greene, M. E. C.; Asiimwe, R.; Wright, E. D.; Bell, M.; Epstein, D.; Knott, B.; Fry, S.; Clevenger, S.; Richter, H. E.; Freud, A. G.; Little, S. C.; Porrett, P. M.
10.1101/2025.07.05.663267 — immunology — Posted on 2025-07-09
1142 A Bioelectrochemical Crossbar Architecture Screening Platform (BiCASP) for Extracellular Electron Transfer
Suresh, H.; Bird, P.; Saha, K.; Devaraj, S. V.; Asci, C.; Truong, A.; Wallman, C.; Patel, R. S.; Sharma, A.; Carpenter, M.; Bontapalle, S.; Verduzco, R.; Silberg, J.; Sonkusale, S.
10.1101/2025.07.09.663982 — synthetic biology — Posted on 2025-07-09
1147 Flexible foraging effort shapes Adelie penguin reproductive success across Antarctica and sea ice conditions
Barracho, T.; Bardon, G.; Houstin, A.; Beaulieu, M.; Blanchard, P.; Cristofari, R.; Lenourry, L.; Raclot, T.; Tabillon, C.; Zitterbart, D.; Lecomte, N.; Le Bohec, C.
10.1101/2025.07.05.663228 — ecology — Posted on 2025-07-09
1148 APEX2 proximity labeling of RNA in bacteria
Yassine, H.; Sirotkin, E.; Goldberger, O.; Lawal, V.; Kearns, D. B.; Schrader, J. M.
10.1101/2024.09.18.612050 — microbiology — Posted on 2025-07-09
1149 Germline polymorphism in the immunoglobulin kappa and lambda loci explain variation in the expressed light chain antibody repertoire
Engelbrecht, E.; Rodriguez, O. L.; Lees, W.; Vanwinkle, Z.; Shields, K.; Schultze, S.; Gibson, W. S.; Smith, D. R.; Jana, U.; Saha, S.; Peres, A.; Yaari, G.; Smith, M. L.; Watson, C. T.
10.1101/2025.05.28.656470 — immunology — Posted on 2025-07-09
1155 JAK2 signalling to HNRNPA1 represses retrotransposon activity in haematopoietic stem cells
Deuel, J. W.; Mararovs, A.; Goosheh, S.; Winder, G.; Mohammed, H.; Carroll, J.; Chapman, M. S.; Kapadia, C. D.; Campbell, P.; Nangalia, J.; Schneider, C.; Oellerich, T.; Green, A. R.; Loughran, S. J.
10.1101/2025.07.07.663405 — cell biology — Posted on 2025-07-09
1159 Epidermal Resident Memory T Cell Fitness Requires Antigen Encounter in the Skin
Weiss, E. S.; Hirai, T.; Li, H.; Liu, A.; Baker, S.; Magill, I.; Gillis, J.; Zhang, Y. R.; Ramcke, T.; Kurihara, K.; The ImmGen Consortium OpenSource T cell Project, ; Masopust, D.; Anandasabapathy, N.; Singh, H.; Zemmour, D.; Mackay, L. K.; Kaplan, D. H.
10.1101/2025.03.31.646438 — immunology — Posted on 2025-07-09
1162 GREmLN: A Cellular Regulatory Network-Aware Transcriptomics Foundation Model
Zhang, M.; Swamy, V.; Cassius, R.; Dupire, L.; Kanatsoulis, C.; Paull, E.; AlQuraishi, M.; Karaletsos, T.; Califano, A.
10.1101/2025.07.03.663009 — bioinformatics — Posted on 2025-07-09
1163 The human immunoglobulin heavy chain constant gene locus is enriched for large complex structural variants and coding polymorphisms that vary in frequency among human populations
Jana, U.; Rodriguez, O. L.; Lees, W.; Engelbrecht, E.; Vanwinkle, Z.; Peres, A.; Gibson, W.; Shields, K.; Schultze, S.; Dorgham, A. G.; Emery, M.; Deikus, G.; Sebra, R.; Eichler, E. E.; Yaari, G.; Smith, M. L.; Watson, C. T.
10.1101/2025.02.12.634878 — genomics — Posted on 2025-07-09
1164 Boundary-guided cell alignment drives mouse epiblast maturation
Ichikawa, T.; Guruciaga, P. C.; Hu, S.; Plunder, S.; Makino, M.; Hamaji, M.; Stokkermans, A.; Yoshida, S.; Erzberger, A.; Hiiragi, T.
10.1101/2025.04.28.650859 — developmental biology — Posted on 2025-07-09
1165 Contrasting Effects of SARS-CoV-2 Vaccination vs. Infection on Antibody and TCR Repertoires
Braun, J.; Hill, E. D.; Contreras, E.; Yasuda, M.; Morgan, A.; Ditelberg, S.; Winter, E.; Callahan, C.; Mazzoni, G.; Kirmaier, A.; Mirebrahim, H.; Asgharian, H.; Telman, D.; Collier, A.-R. Y.; Barouch, D. H.; Riedel, S.; Dutta, S.; Rubelt, F.; Arnaout, R.
10.1101/2023.09.08.556703 — immunology — Posted on 2025-07-09
1167 Cognition-centric brain activity across diverse imaging tasks constrains the representation of mental health in brain function data
Korponay, C.; Cohen-Gilbert, J. E.; Kumar, P.; Harnett, N. G.; Medina, A. A.; Cheng, Y.; Forester, B. P.; Ressler, K. J.; Demsar, J.; Frederick, B. B.; Beckmann, C. F.; Harper, D. G.; Nickerson, L. D.
10.1101/2025.06.11.659091 — neuroscience — Posted on 2025-07-09
1168 The transcription factor AP-2β defines active enhancers conferring molecular apocrine cell identity in breast cancer
Mustafa, E.; Laven-Law, G.; Kikhtyak, Z.; Bergeron, A.; MacGrogan, G.; Winter, J.; Dwyer, A.; Pederson, S.; Tilley, W. D. D.; Iggo, R. D.; Hickey, T.
10.1101/2025.07.05.663274 — cancer biology — Posted on 2025-07-09
1169 A transient mechanical crosstalk between Adherens Junctions and Focal Adhesions sustains cell proliferation in premalignant breast epithelial cells
Faria, L.; Goncalves, C. M.; Fidalgo, I.; Lopes, C. S.; Rodrigues, V.; Azevedo, M. M.; Paula Sampaio, P.; Tavares, S.; Mahajan, V.; Taubenberger, A.; Janody, F.
10.1101/2025.07.05.663275 — cancer biology — Posted on 2025-07-09
1170 Fast, Bright and Reversible Rhodamine Tags for Live-Cell Imaging
Kompa, J.; Dornfeld, L. J.; Porzberg, N.; Jang, S.; Lilje, S. H.; Catapano, C.; Jocher, D.; Merk, L.; Zedlitz, S.; Mao, R.; Wilhelm, J.; Dietz, M. S.; Tarnawski, M.; Hiblot, J.; Heilemann, M.; Johnsson, K.
10.1101/2025.07.06.663254 — bioengineering — Posted on 2025-07-09
1172 A quantitative pipeline for whole-mount deep imaging and analysis of multi-layered organoids across scales
Gros, A.; Vanaret, J.; Dunsing-Eichenauer, V.; Rostan, A.; Roudot, P.; Lenne, P.-F.; Guignard, L.; Tlili, S.
10.1101/2024.08.13.607832 — biophysics — Posted on 2025-07-09
1175 A Prelude to Conservation Genomics: First Chromosome-Level Genome Assembly of a Flying Squirrel (Pteromyini: Pteromys volans)
Wehrenberg, G.; Kiebler, A.; Greve, C.; Beltran-Sanz, N.; Ben Hamadou, A.; Meissner, R.; Winter, S.; Prost, S.
10.1101/2025.03.20.644356 — genomics — Posted on 2025-07-09
1176 The Oscarella sponge genus: a hidden yet colorful diversity
Guiollot, E.; Guillemain, D.; Renard, E.; Borchiellini, C.; Schenkelaars, Q.
10.1101/2024.10.26.620226 — evolutionary biology — Posted on 2025-07-09
1177 Tor1 dysfunction promotes phenotypic diversity in the asexual fungus Candida albicans
Zacchi, L. F.; Rohling, J.; Johnson, N.; Anderson, M. T.; Southern, P. J.; Davis, D. A.
10.1101/2023.05.12.539650 — genetics — Posted on 2025-07-09
1178 Spatial and longitudinal tracking of enhancer-AAV vectors that target transgene expression to injured mouse myocardium
Wolfson, D.; Hull, J.; Li, Y.; Gonzalez, T.; Jayaram, M.; Devlin, G.; Cigliola, V.; Oonk, K.; Rosales, A.; Bursac, N.; Asokan, A.; Poss, K. D.
10.1101/2025.04.28.651096 — developmental biology — Posted on 2025-07-09
1181 PKA regulates stress granule maturation to allow timely recovery after prolonged starvation
Kroschwald, S.; Uliana, F.; Wilson-Zbinden, C.; Timofiiva, A.; Zhou, J.; Lee, S. S.; Gillet, L.; Zanella, M.; Othman, A.; Mezzenga, R.; Peter, M.
10.1101/2025.07.06.663161 — cell biology — Posted on 2025-07-09
1183 Liquid-like transcription condensates locally constrain chromatin in living human cells
Semeigazin, A.; Minami, K.; Shimazoe, M. A.; Khochbin, S.; Panne, D.; Ide, S.; Maeshima, K.
10.1101/2025.07.05.663270 — cell biology — Posted on 2025-07-09
1184 A direct RNA-seq-based EBV Latency Transcriptome Offers Insights into the Biogenesis of EBV Gene Products.
Mamane-Logsdon, A.; Zane, I.; Chong, J. S.; Chou, O. H. I.; Rawal, M.; Gillman, A. C. T.; Wongwiwat, W.; Saleban, M.; Donovan-Banfield, I.; Matthews, D. A.; White, R. E.
10.1101/2025.04.23.648900 — microbiology — Posted on 2025-07-09
1185 N-glycosylation engineering in chimeric antigen receptor T cells enhances anti-tumor activity
De Bousser, E.; Festjens, N.; Plets, E.; Meuris, L.; Vuylsteke, L.; Fijalkowska, D.; Van Hecke, A.; Wyseure, E.; Goossens, M.; De Pryck, L.; Van den Bosch, S.; De Munter, S.; Vandekerckhove, B.; Callewaert, N.
10.1101/2023.01.23.525164 — immunology — Posted on 2025-07-09
1187 Whole-brain meso-vein imaging in living humans using fast 7 T MRI
Gulban, O. F.; Stirnberg, R.; Tse, D. H. Y.; Pizzuti, A.; Koiso, K.; Archila-Melendez, M. E.; Huber, R.; Bollmann, S.; Goebel, R.; Kay, K.; Ivanov, D.
10.1101/2025.03.23.644588 — neuroscience — Posted on 2025-07-09
1188 A retrospective analysis of 400 publications reveals patterns of irreproducibility across an entire life sciences research field
Lemaitre, J.; Polpeka, D.; Ribotta, B.; Westlake, H.; Chakrabarti, S.; Xiaoxue, L.; Hanson, M. A.; Jiang, H.; Di Cara, F.; Kurant, E.; David, F.; Lemaitre, B.
10.1101/2025.07.07.663460 — scientific communication and education — Posted on 2025-07-09
1189 Exploiting the polypharmacology of alectinib for synergistic RNA splicing disruption with RBM39 degraders
Ma, Y.; Poon, E.; Jin, C.; Martins da Costa, B.; Xu, Y.; Quazi, S.; Zourdoumis, N.; Wickremesinghe, C.; Chesler, L.; Keun, H. C.; Nijhuis, A.
10.1101/2025.03.28.644532 — cancer biology — Posted on 2025-07-09
1191 Intestinal LKB1 loss drives a pre-malignant program along the serrated cancer pathway
Plugge, S. F.; Ma, H.; van der Vaart, J. Y.; Sprangers, J.; Morsink, F. H. M.; Xanthakis, D.; Jamieson, C.; Stroot, K. B. W.; Keijzer, A. R.; Margaritis, T.; Candelli, T.; Straver, R.; de Ridder, J.; Holstege, F. C. P.; de Leng, W. W. J.; Offerhaus, G. J. A.; Merenda, A.; Maurice, M. M.
10.1101/2023.07.17.548873 — cancer biology — Posted on 2025-07-09
1192 Lumen charge governs gated ion transport in β-barrel nanopores
Mayer, S. F.; Mitsioni, M.; Robin, P.; van den Heuvel, L.; Ronceray, N.; Marcaida, M. J.; Abriata, L. A.; Krapp, L. F.; Anton, J. S.; Soussou, S.; Jeanneret-Grosjean, J.; Fulciniti, A.; Moller, A.; Vacle, S.; Feletti, L.; Brinkerhoff, H.; Laszlo, A. H.; Gundlach, J. H.; Emmerich, T.; Dal Peraro, M.; Radenovic, A.
10.1101/2024.09.26.615172 — biophysics — Posted on 2025-07-09
1194 Expanded gut microbial genomes from Chinese populations reveal population-specific genomic features related to human physiological traits
Dong, Q.; Ma, B.; Zhou, X.; Huang, P.; Gao, M.; Yang, S.; Jiao, Y.; Zhou, Y.; Shi, Z.; Deng, Q.; Hua, D.; Wang, X.; Liu, L.; Zhang, C.; Zhang, C.; Kong, M.; He, C.; Wu, T.; Zou, H.; Shi, J.; Sheng, Y.; Wang, Y.; Tang, L.; Hu, S.; Zhong, H.; Sun, W.; Chen, W.; Zhai, Q.; Kong, X.; Zheng, Y.; Chen, L.
10.1101/2024.10.19.618999 — genomics — Posted on 2025-07-09
1195 scooby: Modeling multi-modal genomic profiles from DNA sequence at single-cell resolution
Hingerl, J. C.; Martens, L. D.; Karollus, A.; Manz, T.; Buenrostro, J. D.; Theis, F. J.; Gagneur, J.
10.1101/2024.09.19.613754 — genomics — Posted on 2025-07-09
1198 Spatial control of secretory vesicle targeting by the Ync13-Rga7-Rng10 complex during cytokinesis
Zhang, S.; Singh, D.; Zhu, Y.-H.; Zhang, K. J.; Melero, A.; Martin, S. G.; Wu, J.-Q.
10.1101/2025.05.13.653810 — cell biology — Posted on 2025-07-09
1199 Understanding the mechanism of facilitation in hoverfly TSDNs
Ghosh, A.; Nicholas, S.; Nordström, K.; Nowotny, T.; Knight, J.
10.1101/2025.03.24.644907 — neuroscience — Posted on 2025-07-09
1200 Nissolia brasiliensis as a non-nodulating model legume
Girou, C.; Keller, J.; Libourel, C.; van Beveren, F.; Bianconi, M.; Dufau, I.; Cravero, C.; Callot, C.; Rodde, N.; Coriton, O.; Huteau, V.; Delaux, P.-M.; Vernie, T.
10.1101/2025.07.08.663655 — plant biology — Posted on 2025-07-09
1203 β-sheet stabilization of the island domain underlies ligand-induced LRR-RP activation of plant immune signaling
Snoeck, S.; Zhang, L.; Studer, V.; Kim, G.; Fernandez-Fernandez, A. D.; Nuernberger, T.; zipfel, c.
10.1101/2025.07.07.663532 — plant biology — Posted on 2025-07-09
1206 High-performance genetically-encoded green and red fluorescent biosensors for pyruvate
Imai, S.; Hario, S.; Suerte, C.; Yamaguchi, I.; Sakoi, K.; Thuen, A.; Meznarich, B.; Drobizhev, M.; Terai, T.; Takahashi-Yamashiro, K.; Campbell, R. E.
10.1101/2025.04.17.649293 — molecular biology — Posted on 2025-07-09
1207 Unraveling fungal endolysosomal network as a potential target for effective disease control
Chen, X.; Chen, X.; Long, Y.; Tian, X.; Fang, Z.; Abubakar, Y. S.; Zheng, H.; Wang, Z.; Zheng, W.
10.1101/2024.08.02.606287 — microbiology — Posted on 2025-07-09
1212 A retrospective analysis of 400 publications reveals patterns of irreproducibility across an entire life sciences research field
Lemaitre, J.; Polpeka, D.; Ribotta, B.; Westlake, H.; Chakrabarti, S.; Xiaoxue, L.; Hanson, M. A.; Jiang, H.; Di Cara, F.; Kurant, E.; David, F.; Lemaitre, B.
10.1101/2025.07.07.663460 — scientific communication and education — Posted on 2025-07-09
1213 The secreted redox sensor roGFP2-Orp1 reveals oxidative dynamics in the plant apoplast
Ingelfinger, J.; Zander, L.; Seitz, P. L.; Trentmann, O.; Tiedemann, S.; Sprunck, S.; Dresselhaus, T.; Meyer, A. J.; Müller-Schüssele, S. J.
10.1101/2025.01.10.632316 — plant biology — Posted on 2025-07-09
1214 Machine Learning Guided Differentiation Therapy Targets Cancer Stem Cells in Colorectal Cancers
Sinha, S.; Alcantara, J.; Perry, K.; Castillo, V.; Ondersma, A.; Banerjee, S.; McLaren, E.; Espinoza, C. R.; Taheri, S.; Vidales, E.; Tindle, C.; Adel, A.; Amirfakhri, S.; Sawires, J. R.; Yang, J.; Bouvet, M.; Ghosh, P.
10.1101/2023.09.13.557628 — cancer biology — Posted on 2025-07-09
1215 Prediction of Gemcitabine sensitivity in resectable Pancreatic Cancer using a Glycation Stress Transcriptomic Signature
Senar, O. A.; Stosic, K.; Bouchart, C.; Navez, J.; Tarfouss, J.; Crake, R.; Verset, L.; Demetter, P.; Mauduit, M.; Conroy, T.; Cros, J.; Nicolle, R.; Detours, V.; Bellahcene, A.; Arsenijevic, T.; Van Laethem, J.-L.
10.1101/2025.07.07.663493 — cancer biology — Posted on 2025-07-09
1216 Robust conformational space exploration of cyclic peptides by combining different MD protocols and force fields
Murail, S.; Sawmynaden, J.; Zemirli, A.; Jusot, M.; Pietrucci, F.; Chomilier, J.; Tuffery, P.; Stratmann, D.
10.1101/2025.03.31.646350 — biophysics — Posted on 2025-07-09
1219 Genome editing of phylogenetically distinct bacteria using portable retron-mediated recombineering
Gonzalez-Delgado, A.; Bonillo-Lopez, L.; Johnson, M. S.; Knoedlseder, N.; Ko, C.-C.; Lekbach, Y.; Oh, J.-H.; Selvakumar, H.; Wold, M. C.; Yu, Z.; Aragon, V.; Gralnick, J. A.; Guell, M.; Hatfull, G.; Keitz, B. K.; Koskella, B.; Mutalik, V. K.; van Pijkeren, J. P.; Shipman, S.
10.1101/2025.06.16.660010 — bioengineering — Posted on 2025-07-09
1221 Reproducibility of Scientific Claims in Drosophila Immunity: A Retrospective Analysis of 400 Publications
Westlake, H.; David, F.; Tian, Y.; Krakovic, K.; Dolgikh, A.; Juravlev, L.; Esmangart de Bournonville, T.; Carboni, A.; Melcarne, C.; Shan, T.; Wang, Y.; Mu, Y.; Kotwal, A.; Pirko, N.; Boquete, J. P.; Schupfer, F.; Rommelaere, S.; Poidevin, M.; Liu, Z.; Kondo, S.; Ratnaparkhi, G. S.; Chakrabarti, S.; Liu, G.; Masson, F.; Li, X.; Hanson, M. A.; Jiang, H.; Di Cara, F.; Kurant, E.; Lemaitre, B.
10.1101/2025.07.07.663442 — genetics — Posted on 2025-07-09
1222 Male gut microbiome mediates post-mating sexual selection in Drosophila
Maggu, K.; Meena, A.; De Nardo, A. N.; Sbilordo, S. H.; Roy, J.; Lüpold, S.
10.1101/2025.05.23.655737 — evolutionary biology — Posted on 2025-07-09
1224 Independent origins of spicules reconcile palaeontological and molecular evidence of sponge evolutionary history
Rossi, M. E.; Keating, J. N.; Kenny, N. J.; Giacomelli, M.; Alvarez-Carretero, S.; Schuster, A.; Cardenas, P.; Taboada, S.; Koutsouveli, V.; Donoghue, P.; Riesgo, A.; Pisani, D.
10.1101/2024.06.24.600355 — evolutionary biology — Posted on 2025-07-09
1230 Autophagy Cargo Profiles in Skeletal Muscle during Starvation and Exercise
Farhan, M.; Lyu, S.; Nguyen, T. P.; Zhang, D.; Liang, H.; Zhou, Y.; An, Y. A.; Yang, H.; Du, G.; Liu, Y.
10.1101/2024.09.29.615610 — cell biology — Posted on 2025-07-09
1231 T cell protrusions enable fast, localised initiation of CAR signalling
Rodilla-Ramirez, C.; Carai, G.; Fox, E.; Zehtabian, A.; Adam, H.; Dallio, K.; Ewers, H.; Su, X.; Bottanelli, F.
10.1101/2025.07.08.662959 — cell biology — Posted on 2025-07-09
1232 Dynamic Monomer-Dimer Transition in Ligand-induced Apelin Receptor Activation
Ji, S.; Wang, W.; Yang, Y.; Xu, P.; Zhang, J.; Zhao, X.; Xi, K.; Zang, S.; Shen, D.; Mao, C.; Shen, Q.; Zhang, Y.
10.1101/2025.02.19.639188 — molecular biology — Posted on 2025-07-09
1233 Structural basis of DNA N6-adenine methylation in eukaryotes
Nan, B.; Yang, W.; Wang, D.; Nie, L.; Wang, Y.; Xu, M.; Guan, W.; Chen, Z.; Zhuang, G.; Gao, S.; Liu, Y.
10.1101/2025.07.08.663716 — molecular biology — Posted on 2025-07-09
1235 AI Discovery of Mechanisms of Consciousness, Its Disorders, and Their Treatment
Toker, D.; Zheng, Z. S.; Thum, J.; Guang, J.; Annen, J.; Miyamoto, H.; Yamakawa, K.; Vespa, P. M.; Laureys, S.; Schnakers, C.; Bari, A.; Hudson, A.; Pouratian, N.; Monti, M. M.
10.1101/2024.10.16.618720 — neuroscience — Posted on 2025-07-09
1240 Topological Analysis of the Human Lymph Node Reticular Network Predicts Outcome in Breast Cancer
Llewellyn, A.; D'Costa, S.; Lam, R.; Gore, J.; Lachina, V.; Shewring, D.; Acton, S. E.; Naidoo, K.
10.1101/2025.07.07.663481 — pathology — Posted on 2025-07-09
1243 Characterization of a core fungal community and captivity-induced "mycobiome" change in Fowler's Toad (Anaxyrus fowleri)
Bradshaw, A. J.; Poo, S.; Malter, T. E.; Strasbaugh, R. M.; Bodner, B.; Hincher, M. R.; Devan-Song, A.; Tabima, J. F.
10.1101/2025.07.08.659677 — microbiology — Posted on 2025-07-08
1244 A shotgun approach for highly multiplexed mammalian metabolic engineering
Trolle, J.; Sessa, S.; Rodrick, T.; Jones, D. R.; Fenyo, D.; Pinglay, S.; Boeke, J. D.
10.1101/2025.07.08.663766 — synthetic biology — Posted on 2025-07-08
1247 A conserved long-range RNA interaction in SARS-CoV-2 recruits ADAR1 to enhance virus proliferation
Yang, S. L.; DeFalco, L.; Wang, S.; Wong, Y. H.; Han, J.; Mok, C. K.; Tan, K. Y.; Lim, S. Y.; Zhao, Z.; Zhang, Y.; Lim, J. J. A.; Xiang, J. S.; Sobota, R.; Wang, L.-f.; Chu, J. J. H.; Merits, A.; Huber, R. G.; Wan, Y.
10.1101/2025.07.07.663401 — genomics — Posted on 2025-07-08
1250 Structural basis of DNA N6-adenine methylation in eukaryotes
Nan, B.; Yang, W.; Wang, D.; Nie, L.; Wang, Y.; Xu, M.; Guan, W.; Chen, Z.; Zhuang, G.; Gao, S.; Liu, Y.
10.1101/2025.07.08.663716 — molecular biology — Posted on 2025-07-08
1251 RNA structural heterogeneity in a eukaryotic cell influences its heat shock response
Wan, Y.; Nagarajan, N.; Wang, J.; Han, J.; Tan, W.; Cheng, A. Y.; Aw, J. G. A.; Wang, Y.; Zeng, G.
10.1101/2025.07.06.663400 — molecular biology — Posted on 2025-07-08
1252 Recruitment of Mre11 to recombination sites during meiosis
Priyadarshini, P.; Survi, M.; Mouloud, W. E. Y.; Bohn, R.; Ballet, S.; Hunter, N.; Volkov, A. N.; Bouuaert, C. C.
10.1101/2025.07.08.663703 — molecular biology — Posted on 2025-07-08
1253 A periplasmic protein complex mediates cell envelope integrity and intrinsic multidrug resistance in Mycobacterium tuberculosis
Klevorn, T.; Brown, C.; Hardy, C. D.; Cuthbert, B. D.; Spencer, A.; Jinich, A.; Chan, L.; Mendoza, J.; de Miranda, R.; Kim, H.; Schnappinger, D.; Rhee, K.; Goulding, C.; Ehrt, S.
10.1101/2025.07.08.663683 — microbiology — Posted on 2025-07-08
1257 Respiratory viral infection is associated with increased Pseudomonas abundance in cystic fibrosis airways
Hilliam, Y.; Armbruster, C. R.; Atteih, S. E.; Rapsinski, G. J.; Moore, J.; Koirala, J.; Krainz, L.; Gaston, J. R.; Williams, J.; Cooper, V. S.; Lee, S. E.; Bomberger, J. M.
10.1101/2025.07.08.663034 — microbiology — Posted on 2025-07-08
1258 Microbial Scl1 Activates TGFBR1 receptor kinase signalling to Drive Fibrosis-Inflammation Axis in Alcohol-Associated Liver Disease
Yadav, M.; Tripathi, G.; Nandi, A.; Shabnam, S.; Sewak, J. K.; Bindal, V.; Sharma, N.; Yadav, S.; Sharma, V.; Sharma, N.; Mathew, B.; Magar, Y.; Deepanshu, D.; Pandey, S.; Saif, R.; Das, S.; Gupta, A.; Parasar, A.; Sehgal, D.; Sharma, S.; Sarin, S. K.; Maras, J. S.
10.1101/2025.07.08.663677 — microbiology — Posted on 2025-07-08
1260 Impact of Bacterial Membrane Vesicles on Cellular Responses in Leishmania amazonensis-Infected Macrophages In Vitro
Francisco, P. H. G.; Jorge, G. P.; Roque, G. A. S.; e Silva, M. F.; da Silva, N. S.; Fagundes, C. C.; Oliveira, A. L. R.; Almeida, F. B.; Brocchi, M.; Giorgio, S.
10.1101/2025.07.08.663775 — microbiology — Posted on 2025-07-08
1261 TDP-43 promotes efficient HSV-1 replication in human DRG-derived neurons
Braspenning, S. E.; Ohnezeit, D.; DeGulis, O. A.; Wilson, A. C.; Mohr, I. J.
10.1101/2025.07.08.662712 — microbiology — Posted on 2025-07-08
1263 Novel midgut smooth muscle necrosis (MSMN) in translucent or glass post-larvae of whiteleg shrimp
Srisala, J.; Sanguanrut, P.; Pawtongsook, S.; Khemayan, K.; Sritunyalucksana, K.; FLEGEL, T. W.
10.1101/2025.07.05.663262 — zoology — Posted on 2025-07-08
1265 Expression of nano-engineered RNA organelles in bacteria
Ng, B.; Fan, C.; Dordevic, M.; Knirsch, A.; Malouf, L.; Fabrini, G.; Nuccio, S. P.; Rubio-Sanchez, R. M.; Christie, G.; Takinoue, M.; Cicuta, P.; Di Michele, L.
10.1101/2025.07.08.663582 — synthetic biology — Posted on 2025-07-08
1267 Discovery of Niclosamide Analogs with Potent Mitochondrial Uncoupling Activity with reduced toxicity
Jiang, H.; Macorano, A.; Xing, E.; Jedoui, M.; Mohammed, S.; Lee, V.; Cheng, J.; McDonough, L.; Cheng, X.; Ye, J.; Li, P.-K.
10.1101/2025.07.04.663252 — pharmacology and toxicology — Posted on 2025-07-08
1269 CAPTAIN: A multimodal foundation model pretrained on co-assayed single-cell RNA and protein
Ji, B.-Y.; Hu, T.-T.; Wang, J.-W.; Liu, M.-M.; Xu, L.-W.; Zhang, Q.-H.; Zhong, S.-Y.; Qiao, L.-B.; Zhang, Y.; Peng, S.-L.; Yu, F.-L.
10.1101/2025.07.07.663366 — bioinformatics — Posted on 2025-07-08
1274 Replication of SARS-CoV-2 Omicron lineages is defined by TMPRSS2 use in environments where ACE2 is complexed with solute carriers SLC6A19 and SLC6A20.
Aggarwal, A.; Ognenovska, S.; Ison, T.; Fichter, C.; Milogiannakis, V.; Afzal, M.; Ospina Stella, A.; Waters, S.; Esneau, C.; Bartlett, N.; Pöhlmann, S.; Hoffmann, M.; Burrell, L. M.; Patel, S.; Ellis, S.; Wehrhahn, M.; Ginn, A.; Martinez, E.; Churchill, M.; Angelovich, T.; Rawlinson, W. D.; Yeang, M.; Kok, J.; Sintchenkov, V.; Parry, R.; Sng, J. D.; Neely, G. G.; Moreno, C. L.; Loo, L.; Kelleher, A. D.; Brilot, F.; Khromykh, A.; Turville, S. G.
10.1101/2025.07.07.663433 — microbiology — Posted on 2025-07-08
1275 Molecular basis for anti-jumbo phage immunity by AVAST Type 5
Muralidharan, A.; Martins Costa, A. R.; Fierlier, D.; van den Berg, D. F.; van den Bossche, H.; Zoumaro-Djayoon, A. D.; Pabst, M.; Pacesa, M.; Correia, B.; Brouns, S. J.
10.1101/2025.07.08.663546 — microbiology — Posted on 2025-07-08
1276 Staphylococcus aureus exhibits spatiotemporal heterogeneity in Sae activity during kidney abscess development
Anil, A.; Braza, R. E.; Liu, B.; Altouma, V.; Adedeji, C.; Welling, A.; Ellison, A. L.; Check, M. H.; Irnov, I.; Prescott, R.; Torres, V. J.; Davis, K. M.
10.1101/2025.07.08.663646 — microbiology — Posted on 2025-07-08
1278 Shedding of mitochondrial Voltage-Dependent Anion Channel-1 (VDAC1) Reflects COVID-19 Severity and Reveals Macrophage Dysfunction
Sjogren, M.; Duner, P.; De Marinis, Y.; Neumann, A.; Leandersson, K.; Rasmussen, M.; Wollheim, C. B.; Salehi, A.
10.1101/2025.07.07.663218 — pathology — Posted on 2025-07-08
1279 Lysosomal Enhancement Prevents Infection with PrPSc, α-Synuclein & Tau Prions
Mercer, R. C. C.; Le, N. T.; Mirza-Romero, N.; Flaherty, E.; Lavigna, G.; Orbe, I. C.; Gatdula, J. R. P.; Fraser, D. G.; Sundaravadivelu, A.; Vultaggio, J. S.; Beeler, A. B.; Chiesa, R.; Telling, G. C.; Harris, D. A.
10.1101/2025.06.24.661349 — neuroscience — Posted on 2025-07-08
1281 Dichotomous transcriptome divergence at the cell-type level between the Drosophila male and female germlines
Hariyani, I. E.; Das, S.; Le, E. M.; Gamero-Castano, C.; Soroudi, T.; Choi, J.; Swarup, V.; Ranz, J. M.
10.1101/2025.07.04.663238 — evolutionary biology — Posted on 2025-07-08
1283 Disentangling urbanisation, climate effects and their interaction on ornamental colourations
Sandmeyer, L.; Lopez-Idiaquez, D.; Fargevieille, A.; Giovannini, P.; Perret, S.; Del Rey, M.; Charmantier, A.; Doutrelant, C.; Gregoire, A.
10.1101/2025.02.19.639098 — ecology — Posted on 2025-07-08
1284 Sox9 prevents retinal degeneration and is required for limbal stem cell differentiation in the adult mouse eye
Hurtado, A.; Lopez-Soriano, V.; Lao, M.; Celis-Barroso, M. A.; Lazuen, P.; Chacon-de-Castro, A.; Ramirez-Casas, Y.; Alaminos, M.; Collinson, J. M.; Burgos, M.; Jimenez, R.; Carmona, F. D.; Barrionuevo, F. J.
10.1101/2024.09.19.613969 — developmental biology — Posted on 2025-07-08
1285 Multiscale radiobiological assessment of laser-driven very high energy electrons versus conventional electrons
Giaccaglia, C.; Bayart, E.; Dubail, M.; Varma, C.; Heinrich, S.; Gautier, J.; Tafzi, A.; Kononenko, O.; Goddet, J.-p.; Lamarre-Jouenne, I.; Fouillade, C.; Flacco, A.
10.1101/2025.05.27.656200 — cell biology — Posted on 2025-07-08
1289 A wireless, 60-channel, AI-enabled neurostimulation platform
Rizzuto, D. S.; Herrema, H. G.; Hu, Z.; Utin, D.; Kahn, J.; Ho, C.; Smiles, A.; Gross, R. E.; Lega, B. C.; Das, S. R.; Kahana, M. J.
10.1101/2025.02.04.635298 — neuroscience — Posted on 2025-07-08
1290 NRCAM variant defined by microexon skipping is a targetable cell surface proteoform in high-grade gliomas
Sehgal, P.; Naqvi, A. S.; Higgins, M.; Liu, J.; Harvey, K.; Jarroux, J.; Kim, T.; Mankaliye, B.; Mishra, P.; Watterson, G.; Fine, J.; Davis, J.; Hayer, K. E.; Castro, A.; Mogbo, A.; Drummer, C.; Martinez, D.; Koptyra, M. P.; Ang, Z.; Wang, K.; Farrel, A.; Quesnel-Vallieres, M.; Barash, Y.; Spangler, J. B.; Rokita, J. L.; Resnick, A. C.; Tilgner, H. U.; DeRaedt, T.; Powell, D. J.; Thomas-Tikhonenko, A.
10.1101/2025.01.09.631916 — cancer biology — Posted on 2025-07-08
1291 High-Resolution Spatial Proteomics Characterises Colorectal Cancer Consensus Molecular Subtypes
Kisakol, B.; Sturrock, A.; Cho, S.; Azimi, M.; Lindner, A.; Salvucci, M.; McDonough, E.; Fay, J.; O'Grady, T.; McCawley, N.; Burke, J. P.; McNamara, D.; Graf, J.; McDade, S.; Longley, D. B.; Ginty, F.; Prehn, J. H.
10.1101/2025.05.07.652478 — cancer biology — Posted on 2025-07-08
1292 Nucleosome wrapping energy in CpG islands and the role of epigenetic base modifications
Giniunaite, R.; Sharma, R.; Maddocks, J. H.; Kriaucionis, S.; Petkeviciute-Gerlach, D.
10.1101/2024.04.06.588401 — biophysics — Posted on 2025-07-08
1294 Graphical and Interactive Spatial Proteomics Image Analysis Workflow
Singh, P.; Wright, J. H.; Smythe, K. S.; Fukuda, B. N.; Hung, L.-H.; Yeung, C. C.; Yeung, K. Y.
10.1101/2025.05.23.655879 — bioinformatics — Posted on 2025-07-08
1295 A novel subtyping method for TNBC with implications for prognosis and therapy
Mesrizadeh, Z.; Mukund, K.; Zabaleta, J.; Valle, L. D.; Tomsic, J.; Neuhausen, S. L.; Ding, Y. C.; Seewaldt, V.; Ochoa, A.; Miele, L.; Subramaniam, S.
10.1101/2025.07.04.663242 — bioinformatics — Posted on 2025-07-08
1297 Cellular function of the GndA microprotein during heat shock
Mohsen, J. J.; Mohsen, M. G.; Jiang, K.; Quinto, L.; Landajuela, A.; Karatekin, E.; Isaacs, F. J.; Slavoff, S. A.
10.1101/2024.06.29.601336 — biochemistry — Posted on 2025-07-08
1299 Genome reorganization and its functional impact during breast cancer progression
Reed, K. S. M.; Fritz, A.; Greenyer, H.; Heselmeyer-Haddad, K.; Frietze, S.; Stein, J.; Stein, G.; Misteli, T.
10.1101/2025.05.14.654144 — genomics — Posted on 2025-07-08
1300 Museum genomics reveals temporal genetic stasis and global genetic diversity in Arabidopsis thaliana
Lopez, L.; Lang, P. L. M.; Marciniak, S.; Kistler, L.; Latorre, S. M.; Haile, A.; Vasquez Cerda, E.; Gamba, D.; Xu, Y.; Woods, P.; Yifru, M.; Kerby, J.; McKay, J. K.; Oakley, C. G.; Agren, J.; Wondimu, T.; Bulafu, C.; Perry, G. H.; Burbano, H. A.; Lasky, J. R.
10.1101/2025.02.06.636844 — evolutionary biology — Posted on 2025-07-08
1301 Multiplexed neuromodulatory-type-annotated whole-brain EM-reconstruction of larval zebrafish
Li, F.-n.; Liu, J.-z.; Shi, C.; Yuan, J.-b.; Lv, Y.-n.; Liu, J.; Zhang, L.-n.; Li, L.-l.; Shen, L.-j.; Chen, X.; Zhai, H.; Chen, B.-h.; Zhang, Y.-c.; Guo, J.-y.; Chen, H.-r.; Yan, H.-y.; Chang, S.; Ma, H.-t.; Zhou, F.-x.; Xin, T.; Dong, X.-h.; Lin, L.-m.; Zhao, X.-h.; Xie, Q.-W.; Fang, Z.-h.; Zu, J.-l.; Tao, R.-k.; Hu, H.-y.; Qian, C.-y.; Wang, Y.-s.; Zhang, C.-m.; Xiang, P.-s.; Yang, Y.-x.; Qian, Y.; Gong, Y.-c.; Du, X.-f.; Han, H.; Du, J.-l.
10.1101/2025.06.12.659365 — neuroscience — Posted on 2025-07-08
1302 Anticipatory Eye Gaze as a Marker of Memory
Schmidig, F. J.; Yamin, D.; Sharon, O.; Nadu, Y.; Nir, J.; Ranganath, C.; Nir, Y.
10.1101/2024.08.14.607869 — neuroscience — Posted on 2025-07-08
1303 Autophagy activators normalize aberrant Tau proteostasis and rescue synapses in human familial Alzheimer's disease iPSC-derived cortical organoids
Labra, S. R.; Compher, J.; Prabhavalkar, A.; Almaraz, M.; Cedeno Kwong, C.; Baal, C.; Talantova, M.; Dolatabadi, N.; Pina-Sanz, J.; Wang, Y.; Yoon, L.; Ghatak, S.; Gao, Z.; Zhang, Y.; Trudler, D.; Massey, L.; Lin, W.; Balistreri, A.; Bula, M.; Mondala, T. S.; Schork, N. J.; Head, S. R.; Kelly, J. W.; Lipton, S. A.
10.1101/2025.06.25.661453 — neuroscience — Posted on 2025-07-08
1304 The nucleus accumbens shell regulates hedonic feeding via a rostral hotspot
Marinescu, A.-M.; Kamal, E.; Leary, P.; Navarro I Batista, K.; Klug, M.; Savic, N.; Le Foll, C.; Labouesse, M. A.
10.1101/2025.05.24.655907 — neuroscience — Posted on 2025-07-08
1305 Accurately Programming Complex Light Regimes with Multi-channel LEDs
Vong, G. Y. W.; Scott, P.; Claydon, W.; Daff, J.; Denby, K.; Ezer, D.
10.1101/2025.06.06.658293 — plant biology — Posted on 2025-07-08
1307 KLF5 controls subtype-independent highly interactive enhancers in pancreatic cancer to regulate cell survival
Ekstrom, T. L.; Dai, Z.; Thiel, J.; Manjunath, M.; Schacherer, N.; Saha, B. J.; Souto, Y.; Abdelrahman, A. M.; Essmann, F.; Beyes, S.; Truty, M. J.; Dong, M.; Johnsen, S. A.
10.1101/2025.06.30.662301 — cancer biology — Posted on 2025-07-08
1308 Bioelectronic Modulation of Glioblastoma via Wireless Carbon Nanotube Porin Interfaces
Groualle, F. E.; Onion, D.; Watts, J.; Rance, G. A.; Noy, A.; Coyle, B.; Rawson, F. J.
10.1101/2025.07.04.663176 — biophysics — Posted on 2025-07-08
1309 OMIDIENT: Multiomics Integration for Cancer by Dirichlet Auto-Encoder Networks
Safinianaini, N.; Valimaki, N.; Bresson, R.; Gorbonos, A.; Rajamaki, K.; Aaltonen, L. A.; Marttinen, P.
10.1101/2025.07.02.662608 — bioinformatics — Posted on 2025-07-08
1317 Branched actin networks mediate macrophage-dependent host microbiota homeostasis.
Vasconcellos, L. R.; Huang, S. C. M.; Suarez-Bonnet, A.; Priestnall, S.; Chakravarty, P.; Varsani-Brown, S.; Winder, M. L.; Shah, K.; Kogata, N.; Stockinger, B.; Way, M.
10.1101/2024.07.18.604111 — immunology — Posted on 2025-07-08
1318 Multimodal induction of fulminant HLH by IL-18 includes virus-specific NK immunodeficiency
Varghese, J. A.; Landy, E.; Huang, L.; Frank-Kamenetskii, A.; Klinghoffer, H.; Morrissette, J.; Dang, V.; Carro, S.; Eisenlohr, L. C.; Canna, S. W.
10.1101/2025.07.04.663237 — immunology — Posted on 2025-07-08
1319 Probabilistic migration events drive transient tissue residency of lymphocytes during homeostasis
Gergelits, V.; Burton, O. T.; Dooley, J.; Roca, C. P.; Bricard, O.; Ghodsinia, A.; Pasciuto, E.; Sunkara, V.; Liston, A.
10.1101/2025.07.04.663225 — immunology — Posted on 2025-07-08
1323 Salmonids exhibit an acute behavioral response to heterothermal environments
Naudascher, R.; Brizzolara, S.; Slomka, J.; Boes, R. M.; Holzner, M.; Silva, L. G. M.; Stocker, R.
10.1101/2024.05.03.592389 — biophysics — Posted on 2025-07-08
1326 A Wearable Brain--Computer Interface for Mitigating Car Sickness via Attention Shifting
Zhu, J.; Bao, X.; Huang, Q.; Wang, T.; Huang, L.; Han, Y.; Huang, H.; Zhu, J.; Qu, J.; Li, K.; Chen, D.; Jiang, Y.; Xu, K.; Wang, Z.; Wu, W.; Li, Y.
10.1101/2024.09.25.614936 — bioengineering — Posted on 2025-07-08
1328 Bringing TB genomics to the clinic: A comprehensive pipeline to predict antimicrobial susceptibility from genomic data, validated and accredited to ISO standards.
Horan, K.; Viberg, L.; Ballard, S.; Globan, M.; Wirth, W.; Bond, K.; Webb, J.; Dorji, T.; Williamson, D.; Sait, M.; Tay, E. L.; Denholm, J.; Seemann, T.; Howden, B.; Sherry, N.
10.1101/2023.11.04.565651 — genomics — Posted on 2025-07-08
1329 Historical Contingency Shapes Toxin Resistance in a Specialist Avian Predator
Mohammadi, S.; Pradhan, S.; Hoffmann, F. G.; Herrera-Alvarez, S.; Deng, Y.; Eacock, A.; Dobler, S.; Storz, J. F.; Rowland, H. M.
10.1101/2025.07.04.662692 — evolutionary biology — Posted on 2025-07-08
1333 TRIM28 regulates pre-mRNA splicing via phosphorylation and SUMOylation networks
Matkovic, V.; Prieto-Garcia, C.; Mosler, T.; Wagner, K.; Hotz, P.; Haidle, F.; Schimmel, J.; Blumel, N.; Galej, W. P.; Vertegaal, A. C. O.; Muller-McNicoll, M.; Zarnack, K.; Muller, S.; Dikic, I.
10.1101/2025.07.07.663440 — cell biology — Posted on 2025-07-08
1334 Lipid packing contributes to the confinement of caveolae to the plasma membrane
Larsson, E.; Kabedev, A.; Pace, H.; Lindwall, J.; Bano, F.; Parton, R. G.; Bergstrom, C. A. S.; Parmryd, I.; Bally, M.; Lundmark, R.
10.1101/2025.03.13.643064 — cell biology — Posted on 2025-07-08
1335 Community Socioeconomic Disadvantage relates to White Matter Hyperintensity Burden in Mid-to-Late Life Adults
Marsland, A. L.; Wu, M.; DeCataldo, M. K.; Aizenstein, H. J.; Li, J.; Ibrahim, T. S.; Manuck, S. B.; Gianaros, P.
10.1101/2025.07.01.662674 — neuroscience — Posted on 2025-07-08
1336 HyperCas12a enables multiplexed CRISPRi screens
Melore, S. M.; McRoberts Amador, C.; Hamilton, M. C.; Gersbach, C. A.; Reddy, T. E.
10.1101/2024.07.08.602263 — genomics — Posted on 2025-07-08
1338 Cortico-striatal dynamics across working memory stages
Villet, M.; Azoulay, B.; Barik, J.; Marie, H.; Bethus, I.
10.1101/2025.07.04.663202 — neuroscience — Posted on 2025-07-08
1341 Musculoskeletal architecture of the shoulder: A comparative anatomy study in bats and mice informing human rotator cuff function
Kurtaliaj, I.; Kunes, J.; Li, S.; Rowley, M.; Forrester, L. A.; Golman, M.; Swartz, S. M.; Levine, W. N.; Genin, G. M.; Thomopoulos, S.
10.1101/2025.07.04.663211 — physiology — Posted on 2025-07-08
1343 Endogenous Nitroalkene Exploits Dependence on Autophagy-Lysosome Pathway in PARPi-Resistant TNBC
Hong, L.; Lee, S.; frisbie, L.; Zhao, Y.; Skoko, J. J.; Merkel, C.; Kataura, T.; Korolchuk, V. I.; Coffman, L.; Lee, A.; Freeman, B. A.; Schopfer, F. J.; Neumann, C. A.
10.1101/2025.07.04.663201 — pharmacology and toxicology — Posted on 2025-07-08
1344 Labile iron pool dynamics do not drive ferroptosis potentiation in colorectal cancer cells
Ponnusamy, V.; Randall, D. R.; Lee, Z. H.; Das, N. K.; Zhao, L.; Buscher, K.; Solanki, S.; Renslo, A. R.; Hsu, P. P.; Shah, Y. M.
10.1101/2025.07.01.662602 — cancer biology — Posted on 2025-07-08
1345 Dynamic convergence of neurodevelopmental disorder risk genes across neurodevelopment
Fernandez Garcia, M.; Retallick-Townsley, K.; Pruitt, A.; Davidson, E.; Balafkan, N.; Warrell, J.; Huang, T.-C.; Kibowen, A.; Chu, Z.; Dai, Y.; Fitzpatrick, S. E.; Meng, R.; Sen, A.; Cohen, S.; Livoti, O.; Khan, S.; Becker, C.; Luiz Teles Silva, A.; Liu, J.; Dossou, G.; Cheung, J.; Liu, S.; Ghorbani, S.; Deans, P. J. M.; DeCiucis, M.; Emani, P.; Gao, H.; Shen, H.; Gerstein, M.; Wang, Z.; Huckins, L.; Hoffman, E.; Brennand, K.
10.1101/2024.08.23.609190 — genetics — Posted on 2025-07-08
1346 Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue
Aakhte, M.; Mueller, G. F.; Roos, L.; Li, J.; Goepel, T.; Weiss, K. R.; Diniz, A. M.; Wenzel, J.; Schwaninger, M.; Moser, T.; Huisken, J.
10.1101/2025.02.21.639411 — developmental biology — Posted on 2025-07-08
1348 A mechanism for telomere-specific telomere length regulation
Teplitz, G. M.; Pasquier, E.; Bonnell, E.; De Laurentiis, E.; Bartle, L.; Lucier, J.-F.; Dawson, D. S.; Wellinger, R. J.
10.1101/2024.06.12.598646 — molecular biology — Posted on 2025-07-08
1350 Metabolic engineering and late-stage functionalization expand the chemical space of the antimalarial premarineosin A
McBride, C. M.; McCauley, M.; Harris, N. R.; Amin, S.; Curtis, B. J.; Verhey-Henke, L.; Teklemichael, A. A.; Oliphant, E. N.; Dranchak, P.; Lev, K. L.; Qu, F.; Snodgrass, H. M.; Lewis, J. C.; Inglese, J.; Su, X.-z.; Pereira, F.; Sherman, D. H.
10.1101/2025.01.28.635342 — microbiology — Posted on 2025-07-08
1351 GPR30 in spinal cholecystokinin-positive neurons modulates neuropathic pain
Chen, Q.; Wu, H.; Xie, S.; Zhu, F.; Xu, F.; Xu, Q.; Sun, L.; Yang, Y.; Xie, L.; Xie, J.; Li, H.; Dai, A.; Zhang, W.; Wang, L.; Jiao, C.; Zhang, H.; Zhou, X.; Xu, Z.-Z.; Chen, X.
10.1101/2024.09.24.614834 — neuroscience — Posted on 2025-07-08
1353 Reconstructing Voice Identity from Noninvasive Auditory Cortex Recordings
Lamothe, C.; Thoret, E.; Trapeau, R.; Giordano, B. L.; Sein, J.; Takerkart, S.; Ayache, S.; Artieres, T.; Belin, P.
10.1101/2024.02.27.582302 — neuroscience — Posted on 2025-07-08
1355 Ulk1(S555) inhibition alters nutrient stress response by prioritizing amino acid metabolism
Willoughby, O. S.; Nichenko, A. S.; Brisendine, M. H.; Amiri, N.; Henry, S. N.; Braxton, D. S.; Brown, J. R.; Jenkins, K. S.; Addington, A. K.; Zaitsev, A. V.; Burrows, S. T.; McMillan, R. P.; Zhang, H.; Tye, S. A.; Najt, C. P.; Craige, S. E.; Rhoads, T. W.; Warren, J. S.; Drake, J. C.
10.1101/2025.06.30.662412 — physiology — Posted on 2025-07-08
1357 Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response
Ruger-Herreros, C.; Svoboda, L.; Male, G.; Srivastava, A.; Höpfner, M.; Jetzinger, K.; Koubek, J.; Kramer, G.; den Brave, F.; Mogk, A.; Gross, D. S.; Bukau, B.
10.1101/2025.04.14.648540 — molecular biology — Posted on 2025-07-08
1358 Cell splitting in Staphylococcus aureus is controlled by an adaptor protein facilitating degradation of a peptidoglycan hydrolase
Barbuti, M. D.; Skjennum, E. F.; Mebus, V. H.; Morales Angeles, D.; Hustad, M.; Marli, M. T.; Frees, D.; Kjos, M.
10.1101/2025.05.11.653310 — microbiology — Posted on 2025-07-08
1359 Glycogen phase separation drives macromolecular rearrangement and asymmetric division in Escherichia coli
Thappeta, Y.; Canas-Duarte, S. J.; Wang, H.; Kallem, T.; Fragasso, A.; Xiang, Y.; Gray, W.; Lee, C.; Hardo, G.; Cegelski, L.; Jacobs-Wagner, C.
10.1101/2024.04.19.590186 — microbiology — Posted on 2025-07-08
1361 The olfactory organ is a site for neuroendocrine modulation of reproduction in zebrafish
Whitlock, K. E.; Tine, E.; Pinto-Borguero, I.; Aguirre-Campos, C.; Escobar P., M.; Fuentes, R.; Ewer, J.
10.1101/2025.07.07.663467 — neuroscience — Posted on 2025-07-08
1362 PolyRNN: A time-resolved model of polyphonic musical expectations aligned with human brain responses
Robert, P.; Van Cang, M. P.; Mercier, M.; Trebuchon, A.; Bartolomei, F.; Arnal, L. H.; Morillon, B.; Doelling, K.
10.1101/2024.11.27.625704 — neuroscience — Posted on 2025-07-08
1363 Projection-specific integration of convergent thalamic and retrosplenial signals in the presubicular head direction cortex
Richevaux, L.; Lim, D.; Nassar, M.; Dias Rodrigues, L.; Mauthe, C.; Cohen, I.; Sol-Foulon, N.; Fricker, D.
10.1101/2023.03.16.533014 — neuroscience — Posted on 2025-07-08
1365 Palbociclib CDK4/6- and Crizotinib MET/ALK/ROS1-inhibitors Synergize to Enhance Senescence and Immune Recognition in Melanoma Cells Independently of BRAF/NRAS Status
Zhang, F.; Boutin, L.; Das, I.; Melief, J.; Singh, M.; Stantic, M.; Alzrigat, M.; Azimi, A.; Baldran, L.; Bazzar, W.; Da Silva Liberio, M.; Goodwin, J.; Tuominen, R.; Höiom, V.; Jerhammar, F.; Egyhazi Brage, S.; Hansson, J.; Kiessling, R.; Selivanova, G.; Wiman, K. G.; Wilhelm, M. T.; Larsson, L.-G.
10.1101/2025.07.04.663080 — cancer biology — Posted on 2025-07-08
1367 High-throughput multi-camera array microscope platform for automated 3D behavioral analysis of freely swimming zebrafish larvae
Chen, H.; Li, K.; Kreiss, L.; Reamey, P.; Pierce, L. X.; Zhang, R.; Da Luz, R.; Chaware, A.; Kim, K.; Cook, C. B.; Yang, X.; Lerner, J. F.; Doman, J.; Begue, A.; Efromson, J.; Harfouche, M.; Horstmeyer, G.; McCarroll, M. N.; Horstmeyer, R.
10.1101/2025.07.07.661868 — animal behavior and cognition — Posted on 2025-07-08
1369 An effector from the potato late blight pathogen bridges ENTH-domain protein TOL9a to an activated helper NLR to suppress immunity
Madhuprakash, J.; Toghani, A.; Pai, H.; Harvey, M.; Bentham, A. R.; Seager, B. A.; Yuen, E. L. H.; De la Concepcion, J. C.; Lawson, D. M.; Stevenson, C. E. M.; Vergara-Cruces, A.; Derevnina, L.; Bozkurt, T. O.; Banfield, M. J.; Kamoun, S.; Contreras, M. P.
10.1101/2025.07.06.663370 — plant biology — Posted on 2025-07-08
1372 mRNABench: A curated benchmark for mature mRNA property and function prediction
Shi, R.; Dalal, T.; Fradkin, P.; Koyyalagunta, D.; Chhabria, S.; Jung, A.; Tam, C. L.; Ceyhan, D.; Lin, J.; Laverty, K. U.; Baali, I.; Wang, B.; Morris, Q.
10.1101/2025.07.05.662870 — genomics — Posted on 2025-07-08
1374 Navigating parasite antigen genetic diversity in the design of Plasmodium vivax serological exposure markers for malaria
Bareng, P.; Wu, K. W.; Takashima, E.; Argyropoulos, D.; Smith, L.; Naung, M.; Mazhari, R.; Schoffer, K.; Kiernan-Walker, N.; Abraham, A.; Lamont, M.; Mehra, S.; Lim, P.; Sattabongkot, J.; Monteiro, W. M.; Lacerda, M. V. G. d.; Healer, J.; Chitnis, C. E.; Tham, W.-H.; Tsuboi, T.; Mueller, I.; Barry, A. E.; Longley, R. J.
10.1101/2025.07.07.663616 — microbiology — Posted on 2025-07-08
1377 Image-based leaf SPAD value and chlorophyll measurement using a mobile phone: enabling accessible and sustainable crop management
Anderson, J.; Boonyaves, K.; Okamoto, H.; Karaket, N.; Chuekong, W.; Garvie, M.; Chabang, N.; Osorio, D.; Supaibulwatana, K.
10.1101/2025.07.08.663527 — plant biology — Posted on 2025-07-08
1378 A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito
Goldman, O. V.; DeFoe, A. E.; Qi, Y.; Jiao, Y.; Weng, S.-C.; Houri-Zeevi, L.; Lakhiani, P.; Morita, T.; Razzauti, J.; Rosas-Villegas, A.; Tsitohay, Y. N.; Walker, M.; Hopkins, B. R.; Mosquito Cell Atlas Consortium, ; Joshua X D Ang, ; Igor Antoshechkin, ; Yu Cai, ; Fangying Chen, ; Yen-Chung Chen, ; Julien Devilliers, ; Linhan Dong, ; Roberto Feuda, ; Paolo Gabrieli, ; Artyom Kopp, ; Hyeogsun Kwon, ; Hsing-Han Li, ; Tzu-Chiao Lu, ; Thalita Lucio, ; Joao T Marques, ; Marcus F Oliveira, ; Roenick P Olmo, ; Umberto Palatini, ; Zeaan M Pithawala, ; Julien Pompon, ; Yan Reis,
10.1101/2025.02.25.639765 — genomics — Posted on 2025-07-08
1379 Decoding functional genes across species with annotation-independent machine learning
Xie, Y.; Li, L.; Zhu, G.; Lu, P.; Ma, J.; Tao, W.; Tang, J.; Wang, C.; Han, G.
10.1101/2025.07.04.662730 — genomics — Posted on 2025-07-08
1380 GAME: Genomic API for Model Evaluation
Luthra, I.; Priyadarshi, S.; Guo, R.; Mahieu, L.; Kempynck, N.; Dooley, D.; Penzar, D.; Vorontsov, I.; Sheng, Y.; Tu, X.; Klie, A.; Drusinsky, S.; Floren, A.; Armand, E.; Alasoo, K.; Seelig, G.; Tewhey, R.; Koo, P.; Agarwal, V.; Gosai, S.; Pinello, L.; White, M. A.; Lal, A.; Zeitlinger, J.; Pollard, K. S.; Libbrecht, M.; Carter, H.; Mostafavi, S.; Kulakovskiy, I.; Hsiao, W.; Aerts, S.; Zhou, J.; de Boer, C. G.
10.1101/2025.07.04.663250 — bioinformatics — Posted on 2025-07-08
1381 Brain-epigenome wide association study (BEWAS) on the effects of two emerging psychedelics: ketamine & MDMA
Semple, M. G.; Mennenga, S. E.; Smith, R.; Dwaraka, V. B.; Cahn, B. R.; Tafur, J.; Rabin, D. M.; Yazar-Klosinski, B.; Lewis, C. R.
10.1101/2025.07.03.663007 — genomics — Posted on 2025-07-08
1382 Allelic Variation in CYP3A4 and PLB1 Drives Feed Efficiency and Immunometabolic Resilience in Beef Cattle
Morenikeji, O. B.; Taiwo, G.; Idowu, M.; Gratz, L. M.; Olabosoye, B.; King, R. E.; Andrews, N. D.; Saccoh, F.; Grytsay, A.; Ogunade, I.
10.1101/2025.07.02.662800 — genetics — Posted on 2025-07-08
1383 Taurine is a Natural Host Cytoadhesion Inhibitor in Asymptomatic Malaria Cases
Diffendall, G.; Millot, P.; Chen, P.; Dorin-Semblat, D.; Aprahamian, F.; Durand, S.; Gamain, B.; Claessens, A.; Scherf, A.
10.1101/2025.07.06.663375 — microbiology — Posted on 2025-07-08
1384 Antibody Responses to Salmonella Typhi Antigens among Typhoid Recovered Individuals in an Endemic Region
Athavale, A.; Subramaniam, A.; Hussain, A.; Rani, I.; Rathore, D. K.; Upadhyay, S. K.; Pandey, A. K.; Malik, P. K.; Awasthi, A.; Rai, R. C.
10.1101/2025.07.04.663140 — immunology — Posted on 2025-07-08
1387 Striatal dopamine modulates reward-reinforced temporal learning in humans.
DiMarco, E. K.; Jiang, A.; Shipp, A. R.; Tatter, S. B.; Laxton, A. W.; Kishida, K. T.
10.1101/2025.07.03.662974 — neuroscience — Posted on 2025-07-08
1389 The neuroimaging correlates of depression established across six large-scale datasets
Hamilton, K. M.; Luo, X. D.; Easley, T. O.; Ahmad, F.; Guo, T.; Jarukasemkit, S.; Modi, H.; Rincon, S. N.; Shelton, C.; Stahl, L.; Wang, Z.; Zhu, Y.; Lenzini, P.; Hannon, K.; Bijsterbosch, J. D.
10.1101/2025.07.02.660888 — neuroscience — Posted on 2025-07-08
1390 Modulation of predictive coding in auditory paradigms of varying complexity in children with Specific Language Impairment.
Martinez, F. J. R.; Martinez, E. I. R.; Ruiz, B. A.; Trevino, A. G.; Pradas, R. M.; Gonzalez, C. M. G.
10.1101/2025.07.02.662722 — neuroscience — Posted on 2025-07-08
1394 Integrative Multi-Omics Analysis Reveals Stress-Specific Molecular Architectures in Soybean under Drought and Rust Infection
Husein, G.; Castro-Moretti, F. R.; Prado, M.; Amorim, L.; Mazzafera, P.; Canales, J.; Monteiro-Vitorello, C. B.
10.1101/2025.07.07.663534 — plant biology — Posted on 2025-07-08
1395 Introducing furanocoumarin biosynthetic genes in tomato results in coumarins accumulation and impacted growth
Bouille, A.; Villard, C.; Galati, G.; Roumani, M.; Fauvet, A.; Grosjean, J.; Hoengenaert, L.; Boerjan, W.; Ralph, J.; Hilliou, F.; Robin, C.; Hehn, A.; Larbat, R.
10.1101/2025.07.07.663522 — plant biology — Posted on 2025-07-08
1398 The pleuroparenchymal fibroelastosis atlas reveals aberrant cell states and their zonation as an alternate roadmap to lung fibrosis
Ruwisch, J.; Cazes, A.; Leiber, L. M.; Borie, R.; Neubert, L.; Christian, L.; De Montpreville, V. T.; Szmul, A.; Moussa, F.; Verleden, S.; Gaedcke, S.; Hegermann, J.; Fuge, J.; Ballmaier, M.; Kamp, J. C.; Greer, M.; Braubach, P.; Werlein, C.; Ius, F.; Graalmann, T.; Aburahma, K.; de Sadaleer, L.; Egashira, R.; Ackermann, M.; Yamda, D.; Hoeper, M.; Falk, C.; Gottlieb, J.; Schiller, H.; Vanaudenaerde, B.; Seeliger, B.; Debray, M.-P.; Bernaudin, J. F.; Knudsen, L.; Bergot, E.; Jacob, J.; Mal, H.; Jonigk, D.; Dettmer, S.; Mordant, P.; Prasse, A.; Fadel, E.; Wuyts, W.; Crestani, B.; Kaminski, N.; J
10.1101/2025.07.06.663336 — cell biology — Posted on 2025-07-08
1401 New Swiss-knife activities of GroEL/Hsp60 proteins
Zhou, Z.; Yang, D.; Lambert, I.; Decroo, C.; Mascolo, C.; Heidig, S.-L.; Karasiewicz, T.; Flot, J.-F.; Prevost, M.; Wattiez, R.; Vandenbussche, G.; Fontaine, V.
10.1101/2025.07.07.663466 — biochemistry — Posted on 2025-07-07
1405 Vertical Transmission of Bovine H5N1 during Pregnancy and Lactation in Mice
Seibert, B. A.; Parish, M. A.; Talukdar, S. N.; Zhang, T.; Chaulagain, S.; Liu, J. A.; Sachithanandham, J.; Schneider, C.; Coughlan, L.; Bowman, A.; Webby, R. J.; Harkema, J. R.; Pekosz, A.; Klein, S. L.
10.1101/2025.07.07.663583 — microbiology — Posted on 2025-07-07
1406 Supplementation with effective microorganisms in earthen ponds affects common carp growth but not overall microbial communities
Jakimowicz, M.; Sidorczuk, K.; Huyben, D.; Hildebrand, F.; Napora-Rutkowski, Łukasz; Hajduk, P.; Sztuka, M.; Mielczarek, M.; Słomian, D.; Szulc, U.; Jarosz, L.; Szyda, J.
10.1101/2025.07.07.663436 — microbiology — Posted on 2025-07-07
1407 AI-powered Deep Visual Proteomics reveals critical molecular transitions in pancreatic cancer precursors
Min, J.; Schweizer, L.; Zonderland, G.; Selvanesan, B. C.; Oldenburg, L.; Bae, S.-W.; Kim, B. J.; Swanson, B. J.; Klute, K. A.; Caffrey, T. C.; Grandgenett, P. M.; Hollingsworth, M. A.; Ummat, I.; Strauss, M. T.; Mund, A.; Maitra, A.
10.1101/2025.07.07.663528 — cancer biology — Posted on 2025-07-07
1411 Genomic and morphometric evidence for Austronesian-mediated pig translocation in the Pacific
Stanton, D. W. G.; Manin, A.; Evin, A.; Tabbada, K.; Linderholm, A.; Drinkwater, R.; Thalmann, O.; Ng'ang'a, S. I.; Amano, N.; Anderson, A.; Barnett, R.; Barriere, P.; Bedford, S.; Bellwood, P.; Brumm, A.; Tien, T. C.; Clark, G.; Crooijmans, R.; Cucchi, T.; Eusebio, M.; Girdland-Flink, L.; Galbusera, P.; Groenen, M.; Hakim, B.; Hawkins, S.; Heiniger, H.; Helgen, K. M.; Herrera, M. J.; Hunt, T.; Kitchener, A. C.; Lee, C.; Macdonald, A. A.; Megens, H.-J.; Meijaard, E.; Mitchell, K. J.; Moran, C.; Mudar, K.; Nidup, K.; Oxenham, M.; Pem, R.; Piper, P. J.; Schachtschneider, K.; Schook, L.; Silva, P
10.1101/2025.07.07.663491 — evolutionary biology — Posted on 2025-07-07
1412 Translation of numerous upstream open reading frames rather than their products is essential for proliferation of human cells of distinct origin
Shepelev, N.; Razumova, E.; Lavrov, A.; Kiniry, S. J.; Makaryuk, A.; Bibisheva, R.; Dontsova, O.; Baranov, P.; Rubtsova, M.
10.1101/2025.07.07.663426 — molecular biology — Posted on 2025-07-07
1415 Small siphophage binding to an open state of the LptDE outer membrane lipopolysaccharide translocon
van den Berg, B.; Dunbar, E.; Clark, R.; Basle, A.; Allyjaun, S.; Newman, H.; Hubbard, J.; Khalid, S.
10.1101/2025.07.07.663478 — microbiology — Posted on 2025-07-07
1417 Lenacapavir-induced capsid damage exposes HIV-1 genomes from nuclear speckles.
Mueller, T. G.; Klaus, S.; Zila, V.; Nopper, S. L.; Golani, G.; Sonntag-Buck, V.; Heuser, A.-M.; Anders-Oesswein, M.; Schwarz, U. S.; Laketa, V.; Mueller, B.; Kraeusslich, H.-G.
10.1101/2025.07.07.663551 — microbiology — Posted on 2025-07-07
1421 UCL-MetIsoLib: A Public High-Resolution Tandem Mass Spectrometry Library for HILIC-Based Isomer-Resolved Profiling of Glycolysis, Central Carbon Metabolism, and Beyond in Urine, Plasma, Tissues, Cells, and Patient-Derived Organoids
Serafimov, K.; Giolito, M. V.; Ibanez, S.; Renoult, O.; Srhir, S.; Rugeles, P. V.; Laloux-Morris, F.; Corbet, C.; Pierrard, J.; Van den Eynde, M.; Lämmerhofer, M.; Feron, O.
10.1101/2025.07.04.663184 — systems biology — Posted on 2025-07-07
1422 Blocking Osteoprotegerin Reprograms Cancer Associated Fibroblast to Promotes Immune Infiltration into the Tumor Microenvironment
Wang, Y.; Apostolopoulou, H.; Sun, I. H.; Bains, A.; Gibbs, D.; Huang, S.; Alliston, T.; Maker, A.; Tlsty, T.; Ntranos, V.; Gardner, J. M.; Bhushan, A.
10.1101/2025.07.04.663190 — cancer biology — Posted on 2025-07-07
1423 A Sulfotransferase from a Gut Microbe Acts on Diverse Phenolic Sulfate Compounds, Including Acetaminophen Sulfate
Close, R.; Kremer, S.; Mitchem, M.; Bellinghiere, A.; Nirmalkar, K.; Borges, C. R.; Krajmalnik-Brown, R.; Shah, D. D.
10.1101/2025.07.07.663557 — biochemistry — Posted on 2025-07-07
1424 Structural and Evolutionary Constraints of Organophosphate Resistance in Dipteran Carboxylesterases
Frkic, R.; Giang, A.; Liu, J.-W.; Esmaeily, M.; Carr, P. D.; Fraser, N. J.; Hopkins, D.; Oakeshott, J. G.; Batterham, P.; Mabbitt, P. D.; Jackson, C. J.
10.1101/2025.07.07.663592 — biochemistry — Posted on 2025-07-07
1429 Diet, Climatic Conditions, and Sex Affect the Mycobiome of Wild Common Marmosets (Callithrix jacchus)
Gombash, B. J.; Garber, P. A.; Finnegan, P. M.; McKenney, A. C.; Bicca-Marques, J. C.; De la Fuente, M. F.; Abreu, F.; Souto, A.; Schiel, N.; Amato, K. R. J.; Mallott, E. K.
10.1101/2025.07.06.663406 — microbiology — Posted on 2025-07-07
1430 Hypoosmolarity inhibits archaeal ammonia oxidation
Gwak, J.-H.; Olabisi, A.; Lee, U.-J.; Abiola, C.; Lee, S.; Do, H.; Choi, Y. J.; Lee, J.-J.; Jung, M.-Y.; Jehmlich, N.; von Bergen, M.; Wagner, M.; Awala, S. I.; Quan, Z.-X.; Rhee, S.-K.
10.1101/2025.07.07.663500 — microbiology — Posted on 2025-07-07
1431 Identification of Viral Activators of the HSV-2 UL13 Protein Kinase
Koyanagi, N.; Takeshima, K.; Shio, S.; Maruzuru, Y.; Kato, A.; Kawaguchi, Y.
10.1101/2025.07.06.663391 — microbiology — Posted on 2025-07-07
1433 Trade-off between branching and polarity controls decision-making during cell migration
Liu, J.; Boix-Campos, J.; Ron, J. E.; Kux, J. M.; Oremek, M. E. M.; Rossi, A. G.; Gov, N.; Saez, P. J.
10.1101/2024.03.29.585638 — biophysics — Posted on 2025-07-07
1437 Pan-cancer analysis in the real-world setting uncovers immunogenomic drivers of acquired resistance post-immunotherapy
Keddar, M. R.; Carrasco Pro, S.; Rabbie, R.; Kalender Atak, Z.; Camelo Stewart, A.; Hammond, S. A.; Douglas C. Palmer, D. C.; Stewart, R.; Burke, K.; Sidders, B.; Davies, J.; Dry, J.; Martincorena, I.; khosla, S.; Schoenfeld, A. J.; Miller, M. L.
10.1101/2025.07.04.663141 — cancer biology — Posted on 2025-07-07
1439 SHLD2 loss is a synthetic vulnerability to Polθ inhibition combined with radiotherapy
Rodriguez-Berriguete, G.; Thambiayah, P.; Cicconi, A.; Machado, N.; Gotorbe, C.; Nderitu, D.; Cheng, W.-C.; Boursier, M. L.; Cerutti, A.; Grinkevich, V.; Hill, B. R.; Koler, K.; Langdon, S. A.; Majithiya, J. B.; Menon, S.; Moore, S.; Neves, J.; Palmer-Deverill, N. M.; Rajendra, E.; Roy-Luzarraga, M.; Thapa, A.; Heald, R. A.; Smith, G. C. M.; Robinson, H. M. R.; Ranzani, M.; Higgins, G. S.
10.1101/2025.07.04.662969 — cancer biology — Posted on 2025-07-07
1443 Genetic basis of traits and local adaptation in UK silver birch
Carleial, R.; Charters, M.; Finzgar, D.; Swift, P.; Anthoney, E.; Sahlstedt, E.; Rinne-Garmston, K.; Clark, J.; Cottrell, J.; Whittet, R.; Buggs, R.
10.1101/2025.07.04.662749 — genomics — Posted on 2025-07-07
1444 Population differences of chromosome 22q11.2 duplication structure predispose differentially to microdeletion and inversion.
Porubsky, D.; Yoo, D.; Dishuck, P. C.; Koundinya, N.; Souche, E.; Harvey, W. T.; Munson, K. M.; Hoekzema, K.; Chan, D. D.; Leung, T. Y.; Santos, M. S.; Meynants, S.; Swillen, A.; Breckpot, J.; Tsapalou, V.; Hasenfeld, P.; Korbel, J. O.; Lansdorp, P. M.; Vermeesch, J. R.; Eichler, E. E.
10.1101/2025.07.04.662981 — genomics — Posted on 2025-07-07
1445 Virulence on Pm4 kinase-based resistance is determined by two divergent wheat powdery mildew effectors
Bernasconi, Z.; Herger, A. G.; Caro, M. d. P.; Kunz, L.; Mueller, M. C.; Stirnemann, U.; Outram, M. A.; Widrig, V.; Neidhart, M.; Isaksson, J.; Schudel, S.; Roesli, S.; Wicker, T.; Bender, K. W.; Zipfel, C.; Dodds, P. N.; Figueroa, M.; Sanchez-Martin, J.; Keller, B.
10.1101/2025.07.04.663163 — genetics — Posted on 2025-07-07
1446 Transgenerational transmission of an environmental modification in quails: changes in phenotypic variance components across three generations
Rousse, S.; Leroux, S.; Gourichon, D.; Calandreau, L.; David, I.; Rau, A.; lagarrigue, S.; Zerjal, T.; Pitel, F.; Eynard, S. E.
10.1101/2025.07.04.663137 — genetics — Posted on 2025-07-07
1447 Historical Contingency Shapes Toxin Resistance in a Specialist Avian Predator
Mohammadi, S.; Pradhan, S.; Hoffmann, F. G.; Herrera-Alvarez, S.; Deng, Y.; Eacock, A.; Dobler, S.; Storz, J. F.; Rowland, H. M.
10.1101/2025.07.04.662692 — evolutionary biology — Posted on 2025-07-07
1449 Warm-loving species perform well under limiting resources:trait combinations for future climate
Levasseur, S. A. Y.; Weber de Melo, V.; Hille Ris Lambers, J.; Klausmeier, C. A.; Kremer, C. T.; Litchman, E.; Reyes, M.; Thomas, M. K.; Narwani, A.
10.1101/2025.07.04.662912 — ecology — Posted on 2025-07-07
1453 Freshwater snail faecal metagenomes reveal environmental reservoirs of antimicrobial resistance genes across two continents
O'Ferrall, A. M.; Juhasz, A.; Jones, S.; Makaula, P.; Namacha, G.; Ame, S.; Oguttu, D.; Foo, A.; Kayuni, S. A.; LaCourse, J. E.; Musaya, J.; Stothard, R.; Roberts, A. P.
10.1101/2025.02.26.640299 — microbiology — Posted on 2025-07-07
1454 Isolation of genetically diverse influenza antibodies highlights the role of IG germline gene variation and informs the design of population-comprehensive vaccine strategies
Fischer, A. A.; Corcoran, M.; Brouwer, P. J. M.; Chernyshev, M.; Gillespie, R. A.; Nicoletto, A.; Loeffler, J. R.; Ferguson, J. A.; Rodriguez, A. J.; Narang, S.; van Gils, M. J.; Castro Dopico, X.; Kanekiyo, M.; Ward, A. B.; Han, J.; Karlsson Hedestam, G. B.
10.1101/2025.07.04.663145 — immunology — Posted on 2025-07-07
1456 DANSE: a pipeline for dynamic modelling of time-series multi-omics data
Jansen Klomp, L. F.; Yan, X.; Snabel, R. R.; Veenstra, G. J. C.; Meijer, H. G. E.; Post, J. N.
10.1101/2025.07.04.663170 — systems biology — Posted on 2025-07-07
1457 Developmental PBDE exposure impairs histamine release from mast cells by altering granule maturation and calcium signaling in adult male and female mice
Franges, J.; Malinowski, L.; De Alwis, C.; Doolittle, T.; Dixon, H.; Tang, Y.; Watson, H.; Peace, J.; Jima, D.; Sombers, L.; McCarthy, G.; Patisaul, H.; Stapleton, H.; Duque-Wilckens, N.
10.1101/2025.06.28.661534 — pharmacology and toxicology — Posted on 2025-07-07
1461 Bioelectronic Modulation of Glioblastoma via Wireless Carbon Nanotube Porin Interfaces
Groualle, F. E.; Onion, D.; Watts, J.; Rance, G. A.; Noy, A.; Coyle, B.; Rawson, F. J.
10.1101/2025.07.04.663176 — biophysics — Posted on 2025-07-07
1468 Functional gene embeddings improve rare variant polygenic risk scores
Londhe, S.; Lindner, J.; Chen, Z.; Holtkamp, E.; Holzlwimmer, F. R.; Casale, F. P.; Brechtmann, F.; Gagneur, J.
10.1101/2024.07.22.604535 — genetics — Posted on 2025-07-07
1470 Integrated landscape genomics reveals biogeography and climate-driven local adaptation in high-altitudes
Wang, N.; Ghimire, P.; Chhetri, P.; Dahal, N.; Yi, C.; Zhang, T.; Zhuoga, S.; Jiangyong, Z.; Lamichhaney, S.
10.1101/2025.07.02.662798 — evolutionary biology — Posted on 2025-07-07
1473 Genetic and plastic effects on trait variability in two major tree species: insights from common garden experiments across Europe
Martinez-Sancho, E.; Christian, R.; Fonti, P.; Benito-Garzon, M.; Bigler, C.; Miranda, J. C.; Argelich, M.; Chmura, D. J.; Clark, J.; Kjaer, E. D.; Hansen, J. K.; Karopka, M.; Liziniewicz, M.; Notzli, M.; Palsson, A.; Richardson, L.; Sahan, E.; Verstege, A.; Whittet, R.; Vitasse, Y.
10.1101/2025.07.04.662556 — ecology — Posted on 2025-07-07
1475 Exploration of chemical probes and conformational flexibility of GID4 - the substrate receptor of human CTLH E3 ligase complex
Kotlarek, D.; Dudek, K.; Wozniak, B.; Pastok, M. W.; Shishov, D.; Cottens, S.; Bista, M.; Krzywiecka, E.; Gorecka-Minakowska, K.; Jurczak, K.; Drmota, T.; Adamczyk, J.; Falinski, S. P.; Gajewska, D.; Klejnot, M.; Krol, A.; Cuprych-Belter, M.; Mames, I.; Mathieu, A.; Podkowka, A.; Przytulski, K.; Skowron, A. N.; Sypien, M.; Takagi, T.; Wanat, W.; Wierzbicki, I. H.; Wisniewski, J.; Szlachcic, A.; Pokladek, Z.; Walczak, M. J.
10.1101/2025.07.01.662521 — molecular biology — Posted on 2025-07-07
1476 Translation-specific disruption of Col1a1 expression in multiple models of Spinal Muscular Atrophy can be rescued by Risdiplam.
Sharma, G.; Paganin, M.; Huang, Y.-T.; Perenthaler, E.; Signoria, I.; Faller, K.; Maniscalco, F.; Perrucci, C.; Donzel, D.; Chaytow, H.; Basso, M.; Lauria, F.; Kothary, R.; Van Der Pol, L.; Claus, P.; Groen, E. J.; Gillingwater, T. H.; Viero, G.
10.1101/2025.06.03.657600 — molecular biology — Posted on 2025-07-07
1477 A chimeric Ad5-Envp-VLP vaccine platform confers broad-spectrum immunity against emerging and re-emerging pathogens
Zhao, L.; Zhang, Y.; Wang, C.; Zheng, Y.; Chen, F.; Feng, Y.; Fang, L.; Wang, Z.; Fu, Z. F.; Zhou, M.
10.1101/2025.07.03.663092 — immunology — Posted on 2025-07-07
1478 Removal of developmentally regulated microexons has a minimal impact on larval zebrafish brain morphology and function
Calhoun, C. C. S.; Capps, M. E. S.; Muya, K.; Gannaway, W. C.; Martina, V.; Conklin, C. L.; Klein, M. C.; Webster, J. M.; Torija-Olson, E. G.; Thyme, S.
10.1101/2024.08.19.608697 — neuroscience — Posted on 2025-07-07
1479 Decoding menopause-induced tissue fibrosis using pan-tissue network inference
Iijima, H.; Yamashita, A.; Galloway, J. L.; Vo, N.; Choi, H. S.; Ambrosio, F.
10.1101/2025.07.03.663094 — systems biology — Posted on 2025-07-07
1481 Cardiomyocyte-specific expression of HIF-1α mediates the cardioprotective effects of Growth Hormone-Releasing Hormone (GHRH)
Takeuchi, R. M. K.; Takeuchi, L. M.; Balkan, W.; Wanschel, A.; Hatzistergos, K. E.; Kulandavelu, S.; Saltzman, R. G.; Shehadeh, L. A.; Sha, W.; Schally, A. V.; Kurtenbach, S.; Hare, J. M.
10.1101/2025.07.03.662389 — physiology — Posted on 2025-07-07
1482 High-throughput analysis of membrane order unveils a hidden dimension in immune cell states
Andronico, L. A.; Gurdap, C. O.; Arora, A.; Sandoz, P. A.; Jiang, Y.; Giatrellis, S.; de Boer, L.; Carannante, V.; Iskrak, S.; Mikes, J.; Buggert, M.; Osterborg, A.; Onfelt, B.; Klymchenko, A. S.; Brodin, P.; Sezgin, E.
10.1101/2024.01.15.575649 — biophysics — Posted on 2025-07-07
1488 The growth-promoting protein TMEM263 is an ER resident that controls early stages of lipid droplet biogenesis
Yalci, K.; Chala, N.; Moss, J.; Zakrzewski, P.; Sevil, R.; Willoughby, L.; Wonklyn, S.; Andrews, T.; Hammond, C. L.; Corey, R. A.; Carroll, B.
10.1101/2025.07.04.663055 — cell biology — Posted on 2025-07-07
1489 CARM1-mediated methylation controls interactions of ALIX with key partners important for cytokinesis
Huard, S.; Suresh, S.; Vayr, J.; Ruggiero, S.; Dakroub, R.; Masson, V.; Petrovic, A.; Dibsy, R.; Thomsen, J.; Hajj Younes, Y.; Vissotsky, C.; Amara, L.; Belmudes, L.; Chatellard, C.; Sadoul, R.; El Marjou, A.; Coute, Y.; Loew, D.; Guerois, R.; Reynoird, N.; Echard, A.; Dubois, T.
10.1101/2025.07.06.663356 — cell biology — Posted on 2025-07-07
1490 In situ Structure of the Human Gap Junction
Eshriew, E.; Kumpula, E.-P.; Sah-Teli, S. K.; Abettan, A.; Djurabekova, A.; Sharma, V.; Huiskonen, J. T.
10.1101/2025.07.04.663179 — cell biology — Posted on 2025-07-07
1491 Surveillance of Japanese Encephalitis Virus in Piggery Effluent and Environmental Samples: A Complementary Tool for Outbreak Detection
Ahmed, W.; Gebrewold, M.; Williams, D. T.; Wang, J.; Smith, W.; Starick, L. G.; Fogarty, R. M.; Richards, K.; Simpson, S.
10.1101/2025.03.27.645166 — molecular biology — Posted on 2025-07-07
1492 Repurposing Host-Derived RNA-seq Data for Microbial Taxonomic and Functional Profiling in Aquaculture Settings
Harding, A.; Diblasi, C.; Manousi, D.; Soung Kwak, J.; Hazlerigg, D. G.; Morkore, T.; Snippen, L. G.; de Leon, A. V.-P.; Saitou, M.
10.1101/2025.04.15.648526 — microbiology — Posted on 2025-07-07
1493 MitoTracker transfers from astrocytes to neurons independently of mitochondria
Hole, K. L.; Norkett, R.; Russell, E.; Strom, M.; Howden, J. H.; Corbett, N. J.; Brownlees, J.; Devine, M. J.
10.1101/2025.05.27.655523 — neuroscience — Posted on 2025-07-07
1495 Phylogenomics of Plasmopara halstedii reveals genomic regions associated with the breakdown of sunflower downy mildew resistance genes
PECRIX, Y.; Dvorak, E.; Labbe, F.; Legrand, L.; CARRERE, S.; Gouzy, J.; Delmotte, F.; Besnard, G.; Godiard, L.
10.1101/2025.06.18.660304 — plant biology — Posted on 2025-07-07
1496 Cholesterol Metabolism in a Murine Model of Vertical Sleeve Gastrectomy
Whang, E.; Ferrari, A.; Kennelly, J. P.; Gao, Y.; Xiao, X.; Jarrett, K.; Bedard, A.; de Aguiar Vallim, T. Q.; Tontonoz, P.
10.1101/2025.07.03.659993 — physiology — Posted on 2025-07-07
1502 CALIPERS: Cell cycle-aware live imaging for phenotyping experiments and regeneration studies
Di Sante, M.; Pezzotti, M.; Zimmermann, J.; Enrico, A.; Deschamps, J.; Balmas, E.; Becca, S.; Solito, S.; Reali, A.; Bertero, A.; Jug, F.; Pasqualini, F.
10.1101/2024.12.19.629259 — bioengineering — Posted on 2025-07-07
1503 Long-Term Potentiation and Closed-Loop Learning in Paired Brain Organoids for CNS Drug Discovery
Rountree, C.; Schmidt, E.; Coungeris, N.; Alstat, V.; LaCroix, A. S.; Morris, M.; Moore, M. J.; Curley, J. L.
10.1101/2025.07.03.663054 — bioengineering — Posted on 2025-07-07
1504 Multiple-testing corrections in case-control studies using identity-by-descent segments
Temple, S. D.; Chapman, N. H.; Choi, S. H.; DeStefano, A. L.; Thornton, T. A.; Wijsman, E. M.; Blue, E. E.
10.1101/2025.07.03.663057 — genetics — Posted on 2025-07-07
1507 Long-range chemical signalling in vivo is regulated by mechanical signals
Pillai, E. K.; Mukherjee, S.; Gampl, N.; McGinn, R. J.; Mooslehner, K. A.; Becker, J.; Winkel, A.; Thompson, A. J.; Franze, K.
10.1101/2024.02.15.580459 — developmental biology — Posted on 2025-07-07
1510 Metabolic and Population Profiles of Active Subseafloor Autotrophs in Young Oceanic Crust at Deep-Sea Hydrothermal Vents
Elkassas, S. M.; Fortunato, C. S.; Grim, S.; Butterfield, D. A.; Holden, J. F.; Vallino, J. J.; Algar, C.; Zeigler Allen, L.; Larson, B.; Proskurowski, G.; Reddington, E.; Stewart, L.; Topcuoglu, B.; Huber, J. A.
10.1101/2025.04.25.650746 — microbiology — Posted on 2025-07-07
1511 A stress-NRF2 response axis polarises tumor macrophages and undermines immunotherapy
Schaer, D. J.; Schulthess-Lutz, N.; Baselgia, L.; Kunasingam, K.; Humar, R.; Hansen, K.; Vallelian, F.
10.1101/2025.07.02.662726 — immunology — Posted on 2025-07-07
1512 Sex differences in the regulation and function of cellular immunity in Drosophila
Dvoskin, A. D.; Allara, M.; Ho, K. Y.; Janz, N.; Rideout, E.; Girard, J. R.; Tanentzapf, G.
10.1101/2025.03.03.641076 — immunology — Posted on 2025-07-07
1513 Lead optimization against drug-resistant Leishmania donovani infection: Semi-synthetic derivatives of ethyl linoleate isolated from Indian edible mushroom Meripilus giganteus.
Nath, S.; Chhetri, K.; Hussain, A.; Chaudhuri, A.; Ghosh, J.; Chakraborty, S.; Mukherjee, D.; Karan, M.; Raychaudhury, B.; Acharya, K.; Chakrabarti, S.; Roy, B. G.; Pal, C.
10.1101/2025.07.03.663049 — immunology — Posted on 2025-07-07
1514 Echinococcus granulosus antigen B acts as an LPS-scavenging lipoprotein in vitro preventing TLR4-mediated activation of dendritic cells
Lagos Magallanes, S.; Beasley Lomazzi, A.; Zamarreno, F.; Carrion, F.; Flo, M.; Dutto, J.; Julve, J.; Costabel, M.; Maccioni, M.; Folle Lopez, A. M.; Ferreira Vazquez, A. M.
10.1101/2025.07.02.662828 — immunology — Posted on 2025-07-07
1516 Cortex-Wide, Cellular-Resolution Volumetric Imaging with a Modular Two-Photon Imaging Platform
Hu, J.; Zhu, Y.; Liu, S.; Li, C.; Zhang, M.; Gu, X.; Wu, J.; Xu, F.; Mao, Y.; Li, B.
10.1101/2025.07.03.662899 — neuroscience — Posted on 2025-07-07
1519 Mechanism and Structure-Guided Optimization of SLC1A1/EAAT3-Selective Inhibitors in Kidney Cancer
Koochaki, P.; Qiu, B.; Coker, J. A.; Earsley, A.; Wang, N. S.; Romigh, T.; Goins, C. M.; Stauffer, S. R.; Boudker, O.; Chakraborty, A. A.
10.1101/2025.07.03.663021 — cancer biology — Posted on 2025-07-07
1522 A scRNA-seq Reference Contrasting Living and Early Post-Mortem Human Retina Across Diverse Donor States
Yang, L.; Tao, Y.; Pan, Q.; Cai, T.; Ye, Y.; Liu, J.; Zhou, Y.; Shao, Y.; Yi, Q.; Lu, Z. H.; Chen, L.; McKay, G.; Rankin, R.; Meng, W.
10.1101/2024.09.13.612968 — bioinformatics — Posted on 2025-07-07
1523 Deep and Quantitative Proteomic Profiling of Low Volume Mouse Serum Across the Lifespan
Dey, A. K.; Olinger, B.; Boroumand, M.; Fernandez, M. E.; SLAM investigators, ; Camandola, S.; Price, N. L.; de Cabo, R.; Basisty, N.
10.1101/2025.06.24.661372 — biochemistry — Posted on 2025-07-07
1528 Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish
Lopez-Blanch, L.; Rodriguez-Marin, C.; Mantica, F.; Iniguez, L. P.; Permanyer, J.; Kita, E. M.; Mackensen, T.; Codina-Tobias, M.; Romero-Ferrero, F.; Fernandez-Albert, J.; Cuadrado, M.; Bustelo, X. R.; de Polavieja, G.; Irimia, M.
10.1101/2024.10.23.619860 — molecular biology — Posted on 2025-07-07
1529 The ParA-like ATPase PldP influences the TatA dynamics in Corynebacterium glutamicum
Karnaukhova, E.; Alwardt, D.; Böhm, K.; Weiss, M.; Meyer, F. M.; Giacomelli, G.; Mehner-Breitfeld, D.; Brüser, T.; Bramkamp, M.
10.1101/2025.07.02.662783 — microbiology — Posted on 2025-07-07
1530 Keratin degradation reflects a starvation survival strategy in Fervidobacterium islandicum AW-1
Sung, J.-Y.; Kim, J.-Y.; Jin, H.-S.; Baek, J.-H.; Kim, N. E.; Song, H. H.; Bong, S.-H.; Lee, Y.-J.; Kim, B.-C.; Lee, D. Y.; Lee, D.-W.
10.1101/2025.07.04.663136 — microbiology — Posted on 2025-07-07
1531 The cryo-EM structure of an adaptor-effector complex reveals the mechanism of a widespread pore-forming toxin family
Velazquez, C.; Zabala-Zearreta, M.; Paredes, C.; Civantos, C.; Altuna-Alvarez, J.; Bernal, P.; Albesa-Jove, D.
10.1101/2025.07.04.663240 — microbiology — Posted on 2025-07-07
1532 Identification and Evaluation of Benzimidazole- Agonists of Innate Immune Receptor NOD2
Wittle, L.; Ocius, K.; Chordia, M.; Van Wagoner, C.; Bullock, T. N.; Pires, M. M.
10.1101/2025.07.03.661155 — immunology — Posted on 2025-07-07
1534 BetaII-Spectrin Gaps and Patches Emerge from the Patterned Assembly of the Actin/Spectrin Membrane Skeleton in Human Motor Neuron Axons
Gazal, N. G.; Castellanos-Montiel, M. J.; Bruno, G.; Franco-Flores, A. K.; Lepine, S.; Gursu, L.; Haghi, G.; Maussion, G.; Anastasia, A.; Bisbal, M.; Gorostiza, E. A.; Durcan, T. M.; Unsain, N.
10.1101/2025.05.09.653215 — neuroscience — Posted on 2025-07-07
1535 The nucleus accumbens shell regulates hedonic feeding via a rostral hotspot
Marinescu, A.-M.; Kamal, E.; Leary, P.; Navarro I Batista, K.; Klug, M.; Savic, N.; Le Foll, C.; Labouesse, M. A.
10.1101/2025.05.24.655907 — neuroscience — Posted on 2025-07-07
1536 Paired and solitary ionocytes in the zebrafish olfactory epithelium
Peloggia, J.; Cheung, K. Y.; Petkova, M.; Schalek, R.; Boulanger-Weill, J.; Wu, Y.; Wang, S.; van Hateren, N. J.; Januszewski, M.; Jain, V.; Lichtman, J. W.; Engert, F.; Piotrowski, T.; Whitfield, T. T.; Jesuthasan, S.
10.1101/2024.11.08.620918 — neuroscience — Posted on 2025-07-07
1537 Accelerating Natural Product Discovery with Linked MS-Genomics and Language/Transformer-Based Models
Tay, D. W. P.; Koh, W.; Ang, S. J.; Wong, Z. M.; Lim, Y. W.; Heng, E.; Yeo, N. Z. X.; Adaikkappan, K.; Wong, F. T.; Lim, Y. H.
10.1101/2025.01.20.633932 — synthetic biology — Posted on 2025-07-07
1538 The ASNS inhibitor ASX-173 potentiates L-asparaginase anticancer activity
Tatarskiy, V.; Chan, W.-K.; Tan, L.; Khamidullina, A.; Mahmud, I.; Kumar, S. V.; Nuzhina, J.; Martinez, S. A.; Tran, B. Q.; Skwarska, A.; Pavlenko, N.; Dorofeeva, A.; Konopleva, M.; Genis, D.; Weinstein, J. N.; Kombarov, R.; Lorenzi, P. L.
10.1101/2025.07.03.662851 — cancer biology — Posted on 2025-07-07
1540 Phaeochromocytomas and paragangliomas harbour tumour-initiating SOX2+ stem cells
Kemkem, Y.; Quinn, M.; Kover, B.; Santambrogio, A.; Kaufman-Cook, J.; Sherwin, O.; Scriba, L. D.; Brempou, D.; Segoviano, M. V.; Cameron, D.; Berger, I.; Ng, W.; Nonaka, D.; Theodoropoulou, M.; Pamporaki, C.; Carroll, P. V.; Izatt, L.; Chapple, J. P.; Bornstein, S. R.; Bechmann, N.; Steenblock, C.; Oakey, R. J.; Andoniadou, C. L.
10.1101/2025.07.03.663006 — cancer biology — Posted on 2025-07-07
1542 Aggresomes protect mRNA under stress in Escherichia coli
Pei, L.; Xian, Y.; Yan, X.; Schaefer, C.; Syeda, A. H.; Howard, J.; Zhang, W.; Liao, H.; Bai, F.; Leake, M. C.; Pu, Y.
10.1101/2024.04.27.591437 — biophysics — Posted on 2025-07-07
1550 An Enhancement of Extrachromosomal Circular DNA Enrichment and Amplification to Address the Extreme Low Overlap Between Replicates
Burnham, C. M.; Kurilung, A.; Wanchai, V.; Regenberg, B.; Delgado-Calle, J.; Basnakian, A. G.; Nookaew, I.
10.1101/2025.06.28.662146 — genomics — Posted on 2025-07-07
1554 Speed Matters: Accelerated Pharmacokinetics Reduce Persisters in Escherichia coli
Ali, K. M.; Murphy, R.; Zanchi, C.; Zunk-Parras, S. A.; Rodriguez-Rojas, A.; Rolff, J.
10.1101/2025.04.25.650648 — evolutionary biology — Posted on 2025-07-07
1556 A non-canonical role for Jagged1 in endothelial mechanotransduction
Suarez Rodriguez, F.; Virtanen, N.; Kiviluoto, E.; Driessen, R. C. H.; Zhao, F.; Bouten, C. V. C.; Stassen, O. M. J. A.; Sahlgren, C. M.
10.1101/2024.11.14.623558 — cell biology — Posted on 2025-07-07
1557 PRMT5 activity sustains histone production to maintain genome integrity
Roth, J. S.; DeAngelo, J. D.; Young, D. L.; Maron, M. I.; Saha, A.; Pinto, H.; Gupta, V.; Jacobs, N.; Hegde, S.; Aguilan, J. T.; Basken, J.; Azofeifa, J.; Query, C. C.; Sidoli, S.; Skoultchi, A.; Shechter, D.
10.1101/2025.07.03.663002 — cell biology — Posted on 2025-07-07
1561 Restoration of locomotor function following stimulation of the A13 region in Parkinson's mouse models
Kim, L. H.; Lognon, A.; Sharma, S. S.; Tran, M. A.; Badenhorst, C.; Chomiak, T.; Tam, S.; McPherson, C.; Stang, T. E.; Eaton, S. E.; Kiss, Z. H.; Whelan, P.
10.1101/2023.08.03.551564 — neuroscience — Posted on 2025-07-07
1563 The transcription factor CLAMP is required for neurogenesis in Drosophila melanogaster.
Tsiarli, M. A.; Kentro, J. A.; Conard, A. M.; Xu, L.; Nguyen, E.; O'Connor-Giles, K. M.; Larschan, E. N.
10.1101/2020.10.09.333831 — neuroscience — Posted on 2025-07-07
1564 Robustness of high-throughput prediction of leaf ecophysiological traits using near infra-red spectroscopy and poro-fluorometry
Coindre, E.; Boulord, R.; Chir, L.; Freitas, V.; Ryckewaert, M.; Laisne, T.; Bouckenooghe, V.; Lis, M.; Cabrera-Bosquet, L.; Doligez, A.; Simonneau, T.; Pallas, B.; Coupel-Ledru, A.; Segura, V.
10.1101/2025.02.07.636194 — plant biology — Posted on 2025-07-07
1566 From sequence to signature: Uncovering multiscale AMR features across bacterial pathogens with supervised machine learning
Ghosh, A.; Brenner, E. P.; Vang, C. K.; Wolfe, E. P.; Burke, J. T.; Lesiyon, R. L.; Manpearl, K. R.; Sridhar, V.; Krol, J. D.; Boyer, E.; Bilodeaux, J. M.; Jongnarangsin, K.; Majlessi, E. J.; Ravi, J.
10.1101/2025.07.03.663053 — bioinformatics — Posted on 2025-07-07
1579 Strip cropping shows promising increases in ground beetle community diversity compared to monocultures
Croijmans, L.; Cuperus, F.; van Apeldoorn, D. F.; Bianchi, F. J. J. A.; Rossing, W. A. H.; Poelman, E.
10.1101/2024.11.02.621655 — ecology — Posted on 2025-07-07
1582 One-step induction of human GABAergic neurons promotes presynaptic development & synapse maturation
van Voorst, T. W.; van boven, M. A.; Marinus, K. I.; Colon-Mercado, J. M.; Schretzmeir, J.; Haag, C.; Toonen, R. F.; Koopmans, F.; Ward, M.; Smit, A. B.; van Kesteren, R. E.; Verhage, M.; Cornelisse, L. N.
10.1101/2025.06.30.662293 — neuroscience — Posted on 2025-07-07
1583 Neural Alpha Oscillations and Auditory Steady State Responses During Adaptation to a Cochlear Implant
Woestmann, M.; Meineke, H. M.; Schoenweiler, R.; Hollfelder, D.; Bruchhage, K.-L.; Leichtle, A.; Obleser, J.
10.1101/2025.02.17.638598 — neuroscience — Posted on 2025-07-07
1585 TS2CG as a membrane builder
Schuhmann, F.; Stevens, J. A.; Rahmani, N.; Lindahl, I.; Brown, C. M.; Brasnett, C.; Anastasiou, D.; Bravo Vidal, A.; Geiger, B. J.; Marrink, S.-J.; Pezeshkian, W.
10.1101/2025.04.16.649160 — biophysics — Posted on 2025-07-07
1588 Ultrasound imaging of in situ transcriptional activity in opaque tissue
Shivaei, S.; Cheung, K. Y. M.; Yadav, A.; Hurvitz, I. U.; Lee, S.; Revilla, J.; Rabut, C.; Criado-Hidalgo, E.; Zhang, R. J.; Shapiro, M. G.
10.1101/2025.07.06.663365 — bioengineering — Posted on 2025-07-07
1589 Giant genome of the vampire squid reveals the derived state of modern octopod karyotypes
Yoshida, M.-a.; Toth, E.; Kon-Nanjo, K.; Kon, T.; Hirota, K.; Toyoda, A.; Toh, H.; Miyazawa, H.; Terauchi, M.; Noguchi, H.; Setiamarga, D. H.; Simakov, O.
10.1101/2025.05.16.652989 — genomics — Posted on 2025-07-07
1590 Coral genetic structure in the Western Indian Ocean mirrors ocean circulation and thermal stress
Guillaume, A. S.; Joost, S.; Curpen, S.; Dumur Neelayya, D.; Harree-Somah, L.; Sadasing, O.; Saponari, L.; Dale, C.; Barret, L.; Andrews, N.; Leckraz, S. K.; Francois, R.; Seetapah, V.; Munusami, V.; Bacha Gian, S.; Jhangeer-Khan, R.; Mahoune, T.; Chumun, P. K.; Poretti, M.; Berteaux-Lecellier, V.; Lecellier, G.; Selmoni, O.
10.1101/2025.06.16.659828 — evolutionary biology — Posted on 2025-07-07
1591 Experimental Test of Evolutionary Safety of a CRISPR-Cas9 Gene-Drive Element
Overton, M. S.; Guy, S. E.; Chen, X.; Martsul, A.; Carolino, K.; Akbari, O.; Meyer, J. R.; Kryazhimskiy, S.
10.1101/2023.11.28.569142 — evolutionary biology — Posted on 2025-07-07
1593 iGABASnFR2: Improved genetically encoded protein sensors of GABA
Kolb, I.; Hasseman, J. P.; Matsumoto, A.; Jensen, T. P.; Kopach, O.; Arthur, B. J.; Zhang, Y.; Tsang, A.; Reep, D.; Tsegaye, G.; Zheng, J.; Patel, R. H.; Looger, L. L.; Marvin, J. S.; Korff, W. L.; Rusakov, D. A.; Yonehara, K.; GENIE Project Team, ; Turner, G. C.
10.1101/2025.03.25.644953 — neuroscience — Posted on 2025-07-07
1594 Fructose-2,6-bisphosphate restores TDP-43 pathology-driven genome repair deficiency in motor neuron diseases
Chakraborty, A.; Mitra, J.; Malojirao, V. H.; Kodavati, M.; Mandal, S. M.; Gill, S. K.; Sreenivasmurthy, S. G.; Vasquez, V.; Mankevich, M.; Bosch, L. V. D.; Garruto, R. M.; Robey, I. F.; Krishnan, B.; Ghosh, G.; Hegde, M.; Hazra, T.
10.1101/2024.11.13.623464 — neuroscience — Posted on 2025-07-07
1595 Inhibitory neurons marked by the connectivity molecule Kirrel3 regulate memory precision
Tunon-Ortiz, A. B. N.; Trankner, D.; Peterson, C. M.; Shennib, O.; Ye, F.; Shi, J.; Brockway, S. N.; Raines, O. K.; Mahnke, A.; Grega, M.; Kim, K.-Y.; Ellisman, M.; Heys, J. G.; Zelikowsky, M.; Williams, M. E.
10.1101/2024.07.05.602304 — neuroscience — Posted on 2025-07-07
1596 Psilocybin has no immediate or persistent analgesic effect in acute and chronic mouse pain models
Gregory, N. S.; Girard, T. E.; Ram, A.; Casey, A. B.; Malenka, R. C.; Tawfik, V. L.; Heifets, B. D.
10.1101/2025.07.06.663398 — neuroscience — Posted on 2025-07-07
1597 Human TDP-43 overexpression in zebrafish motor neurons triggers MND-like phenotypes through gain-of-function mechanism
Hogan, A. L.; Kane, M.; Chiu, P.; Ritcher, G.; Maurel, C.; Wu, S.; Scherer, N. M.; Don, E. K.; Lee, A.; Blair, I.; Chung, R.; Morsch, M.
10.1101/2025.07.06.663393 — neuroscience — Posted on 2025-07-07
1598 LCK-targeting molecular glues overcome resistance to inhibitor-based therapy in T-cell acute lymphoblastic leukemia
Yang, J. J.; Nishiguchi, G.; Yoshimura, S.; Actis, M.; Seffernick, J. T.; Jarusiewicz, J. A.; Aggarwal, A.; Li, A.; Li, Y.; Lee, D.; Yang, L.; Mayasundari, A.; Rankovic, Z.; Fischer, M.
10.1101/2025.07.03.663042 — cancer biology — Posted on 2025-07-07
1600 A pan-cancer atlas of therapeutic T cell targets
Li, G.; Guzman-Bringas, O. U.; Sharma, A.; Dellacherie, M.; Sekhri, P.; Yamin, R.; Stepec, D.; Burq, M.; Clotea, I.; Tardio, E.; Natarajan, A.; Harpaz, Z.; Liu, X.; Requena, D.; Taylor, D.; Ueberheide, B.; Krogsgaard, M.; Cruz, C. R.; Cimermancic, P.; Yarmarkovich, M.
10.1101/2025.01.22.634237 — cancer biology — Posted on 2025-07-07
1601 Electron diffraction captures high-resolution structures from in vivo protein nanocrystals of Bacillus thuringiensis
Gallagher-Jones, M.; Buecker, R.; Delaunay, Q.; Coquelle, N.; Andreeva, E.; Smith, A.; Zala, N.; Montmayeul, P.; Miller, R. J. D.; Kim, J. S.; Kirkland, A. I.; Colletier, J.-P.
10.1101/2025.06.24.661318 — biophysics — Posted on 2025-07-07
1602 The systematic assessment of completeness of public metadata accompanying omics studies in the Gene Expression Omnibus
Huang, Y.-N.; Jaiswal, P. V.; Rajesh, A.; Yadav, A.; Yu, D.; Liu, F.; Scheg, G.; Shih, E.; Boldirev, G.; Nakashidze, I.; Mehta, J. H.; Wang, K.; Patel, K. K.; Sarkar, A.; Mirza, M. A. B.; Hu, J.; Peng, Q.; Hapani, K. C.; Ayyala, R.; Guo, R.; Wong, M. Y.; Kapur, S.; Ramesh, T.; Ciorba, D.; Munteanu, V.; Bostan, V.; Dimian, M.; Abedalthagafi, M. S.; Mangul, S.
10.1101/2021.11.22.469640 — bioinformatics — Posted on 2025-07-07
1604 Development of circulating cell-free DNA reduced representation bisulfite sequencing for clinical methylomics diagnostics
De Koker, A.; Raman, L.; Van Paemel, R.; Van der Linden, M.; Van de Velde, S.; Van der Leest, P.; Van Gaever, B.; Zaka, A.; Vermaelen, K.; Demedts, I.; Surmont, V.; Himpe, U.; Dedeurwaerdere, F.; Ferdinande, L.; Claes, K.; De Wilde, J.; Timens, W.; De Jager, V.; Hiltermann, J.; De Wilde, B.; Menten, B.; De Preter, K.; Schuuring, E.; Van Dorpe, J.; Callewaert, N.
10.1101/663195 — genomics — Posted on 2025-07-07
1605 Genomic and morphological characterization of Trichuris incognita n. sp., a Human-Infecting Trichuris species
Baer, M. A.; Kouame, N. A.; Toure, S.; Coulibaly, J. T.; Schneeberger, P. H. H.; Keiser, J.
10.1101/2024.06.11.598441 — genomics — Posted on 2025-07-07
1606 Phylogeny, systematics and evolution of mimicry patterns in Neotropical limenitidine butterflies
Paez, E.; Kergoat, G. J.; Chazot, N.; Benmesbah, M.; Briscoe, A. D.; Finkbeiner, S. D.; Freitas, A. V. L.; Guralnick, R. P.; Hill, R. I.; Kronforst, M. R.; Moraes Magaldi, L.; Mullen, S. P.; Nakamura, I.; Owens, H. L.; Wahlberg, N.; Woodbury, M.; Elias, M.; Willmott, K. R.
10.1101/2025.07.03.662938 — evolutionary biology — Posted on 2025-07-07
1610 The evolution of high-order genome architecture revealed from 1,000 species
Che, Y.; Stephen, B.; Lin, H.; Yang, X.; Xie, Q.; Liu, Y.; Meng, D.; Ye, K.
10.1101/2025.07.05.663309 — evolutionary biology — Posted on 2025-07-07
1611 Role of collagen-like protein BclA3 in the assembly of the exosporium layer of Clostridioides difficile spores.
Pizarro-Guajardo, M.; Ortega-Lizarraga, C.; Inostroza-Mora, A.; Cid-Rojas, F.; Paredes-Sabja, D.
10.1101/2021.06.21.449304 — microbiology — Posted on 2025-07-07
1612 INTEROCEPTIVE INFORMATION OF PHYSICAL VIGOR THROUGH CIRCULATING INSULIN-LIKE GROWTH FACTOR 1
Zegarraa Valdivia, J. A.; Khan, M. Z.; Fernandes, J.; Esparza, J.; Suda, K.; Fernandez de Sevilla, M. E.; Diaz-Pacheco, S.; Aleman, I. T.
10.1101/2021.05.25.445442 — neuroscience — Posted on 2025-07-07
1613 An expanded reference catalog of translated open reading frames for biomedical research
Chothani, S.; Ruiz-Orera, J.; Tierney, J. A. S.; Clauwaert, J.; Deutsch, E. W.; Alba, M. M.; Aspden, J. L.; Baranov, P. V.; Bazzini, A. A.; Bruford, E. A.; Brunet, M. A.; Cardon, T.; Carvunis, A.-R.; Casola, C.; Choudhary, J. S.; Dean, K.; Faridi, P.; Fierro-Monti, I.; Fournier, I.; Frankish, A.; Gerstein, M.; Hubner, N.; Jiang, Y.; Kellis, M.; Kok, L. W.; Martinez, T. F.; Menschaert, G.; Ni, P.; Orchard, S.; Roucou, X.; Rozowsky, J.; Salzet, M.; Siragusa, M.; Slavoff, S.; Swirski, M. I.; Valen, E.; Vizcaino, J. A.; Wacholder, A.; Wu, W.; Xie, Z.; Yang, Y. T.; Moritz, R. L.; Mudge, J.; van Hee
10.1101/2025.07.03.662928 — genomics — Posted on 2025-07-07
1617 Seroprevalence and risk factors for Toxoplasma gondii transmission in wild, domestic and companion animals in urban informal settlements from Salvador, Brazil
Bazan, L.; Argibay, H. D.; Borges-Silva, W.; Pita Gondim, L. F.; dos Santos Mattos, T. A.; Oliveira Santana, J.; Mendes da Silva, E.; Begon, M.; Khalil, H.; Costa, F.; de Oliveira Carneiro, I.
10.1101/2025.07.01.662552 — ecology — Posted on 2025-07-07
1618 High-dimensional Immune Profiling Following Autologous Hematopoietic Stem Cell Transplantation in Relapsing-Remitting Multiple Sclerosis
Gavasso, S.; Haugsoen, J. B.; Kleftogiannis, D.; Gerking, Y.; Anandan, S.; Herdlevaer, I.; Olsen, H.; Brun, M.; Blaser, N.; Gjertsen, B. T.; Olsnes, A. M.; Kristoffersen, E. K.; Myhr, K.-M.; Torkildsen, O. F. G.; Bo, L.; Lehmann, A. K.
10.1101/2025.07.01.662494 — immunology — Posted on 2025-07-07
1619 Education Shapes the Link Between EEG Aperiodic Components and Cognitive Aging
Lago, S.; Zago, S.; Montemurro, S.; Calabro, R. S.; Maggio, M. G.; Dattola, S.; Casetta, I.; Arcara, G.
10.1101/2025.07.02.662700 — neuroscience — Posted on 2025-07-07
1621 Neural Timescale of Adolescents Major Depressive Disorder
Gao, Y.; Wang, S.; Wei, H.; He, J.; Liu, G.; Liu, L.; Liu, X.; Xiao, L.; Guo, X.; Liu, X.
10.1101/2025.07.01.662431 — neuroscience — Posted on 2025-07-07
1622 Long-term independent use of an intracortical brain-computer interface for speech and cursor control
Card, N. S.; Singer-Clark, T.; Peracha, H.; Iacobacci, C.; Hou, X.; Wairagkar, M.; Fogg, Z.; Offenberg, E. C.; Hochberg, L. R.; Brandman, D. M.; Stavisky, S. D.
10.1101/2025.06.26.661591 — neuroscience — Posted on 2025-07-07
1623 Towards Precision Functional Brain Network Mapping in Parkinsons Disease
Chernicky, J.; Dworetsky, A.; Grossen, S.; Carr, E.; Eid, A.; Campbell, M. C.; Gratton, C.
10.1101/2025.07.01.662626 — neuroscience — Posted on 2025-07-07
1625 High precision fluorescence tomography-guided system for pre-clinical radiation research: system design and validation
Xu, X.; Tseng, Y.; Deghhani, H.; Hardy, L.; Tong, Z.; Guo, G.; Habib, A.; Iordachita, I.; Wong, J.; Wang, K. K.-H.
10.1101/2025.07.03.662589 — bioengineering — Posted on 2025-07-06
1626 Fubylation as a Druggable Ubiquitin-Like Conjugation System Controlling Hippo Pathway Activity
Bulos, M. L.; Grzelak, E. M.; Nutsch, K.; Elshan, N. G. R. D.; Chatterjee, A. K.; Bollong, M. J.
10.1101/2025.07.06.663376 — biochemistry — Posted on 2025-07-06
1628 Trypanosoma brucei from pigs in sleeping sickness foci from Cote Ivoire is structured into clonal and strongly subdivided populations
NDJETCHI, M. K.; DE MEEUS, T.; TRAORE, B.; RAVEL, S.; SEGARD, A.; KABORE, J.; ABE, A.; KABA, D.; DJAKARIDJA, B.; KONAN, T.; COULIBALY, B.; GREBAUT, P.; BOSSARD, G.; BUCHETON, B.; KOFFI, M.; JAMONNEAU, V.
10.1101/2025.07.03.662103 — genetics — Posted on 2025-07-06
1629 Phagosome Maturation in Macrophages is Enhanced by p38α MAPK Signaling
Shah, M.; Kirthivasan, N.; Chakraborty, S.; Krishnan, Y.; Jhunjhunwala, S.
10.1101/2025.07.03.662985 — cell biology — Posted on 2025-07-06
1631 DIA-PASEF Proteomic Profiling Reveals MpkA-Dependent Iron Stress Responses and Siderophore Biosynthesis in Aspergillus nidulans
Lee, J.; West, O. K.; Huso, W.; Doan, A. G.; Gray, K. J.; Edwards, H.; Tran, J. T.; Carman, D. R.; Betenbaugh, M.; Srivastava, R.; Harris, S.; Marten, M. R.
10.1101/2025.07.03.662993 — systems biology — Posted on 2025-07-06
1632 Zero-shot antibody design in a 24-well plate
Chai Discovery, ; Boitreaud, J.; Dent, J.; Geisz, D.; McPartlon, M.; Meier, J.; Qiao, Z.; Rogozhnikov, A.; Rollins, N.; Wollenhaupt, P.; Wu, K.
10.1101/2025.07.05.663018 — synthetic biology — Posted on 2025-07-06
1633 Transient YAP/TAZ inhibition exposes therapeutic vulnerabilities in advanced cancers
Jessen, M.; Kim, K.; Tollot-Wegner, M.; Vranesic, A. C.; Doenmez, C.; Junker, C.; Lehmann, T.; Khandelwal, A.; Kurlishchuk, Y.; Huenniger, T.; Ritter, C.; Di Napoli, E.; Krishnan, M. S.; Buck, V.; Muth, S.; Tang, T.; Rosenwald, A.; Inverso, D.; Radsak, M.; Paciello, O.; von Eyss, B.
10.1101/2025.07.03.662986 — cancer biology — Posted on 2025-07-06
1636 Multi-omics time-series analysis in microbiome research: a systematic review
Sherwani, M. K.; Ruuskanen, M.; Feldner-Busztin, D.; Firbas, P. N.; Boza, G.; Moreh, A.; Borman, T.; Erawijantari, P. P.; Scheuring, I.; Gopalakrishnan, S.; Lahti, L.
10.1101/2025.07.03.659054 — bioinformatics — Posted on 2025-07-06
1638 Why do some predicted protein structures fold poorly? Benchmarking AlphaFold, ESMFold, and Boltz in maize
Haley, O. C.; Tibbs-Cortes, L.; Hayford, R. K.; Harding, S.; Woodhouse, M. R.; Cannon, E. K.; Gardiner, J. M.; Portwood, J. L.; Sen, T. Z.; Kim, H.-S.; Andorf, C. M.
10.1101/2025.07.05.663230 — bioinformatics — Posted on 2025-07-06
1639 Product-stabilized filamentation by human glutamine synthetase allosterically tunes metabolic activity
Greene, E.; Muniz, R.; Yamamura, H.; Hoff, S. E.; Bajaj, P.; Lee, D. J.; Thompson, E. M.; Arada, A.; Lee, G. M.; Bonomi, M.; Kollman, J. M.; Fraser, J. S.
10.1101/2025.07.04.663231 — bioinformatics — Posted on 2025-07-06
1641 Microtubule end stabilisation by cooperative oligomers of Ska and Ndc80 complexes
Radhakrishnan, R. M.; Stokes, L.; Day, M.; Huis in 't Veld, P. J.; Volkov, V. A.
10.1101/2025.07.06.663352 — biochemistry — Posted on 2025-07-06
1642 Molecular Basis for Asynchronous Chain Elongation During Rifamycin Antibiotic Biosynthesis
Liu, C.; West, R. C.; Chen, M.; Cohn, W.; Wang, G.; Mandot, A. M.; Kim, S.; Cogan, D. P.
10.1101/2025.07.05.663307 — biochemistry — Posted on 2025-07-06
1646 An Epigenomic Roadmap Primes Non-Growing Oocytes for Maturation and Early Embryogenesis
Hu, M.; Munakata, Y.; Yeh, Y.-H.; Wang, H.; Hunter, N.; Schultz, R. M.; Namekawa, S. H.
10.1101/2025.07.06.663377 — developmental biology — Posted on 2025-07-06
1647 The proximal proteome of FLOWERING LOCUS T LIKE 1 during rice panicle development suggests cell-to-cell mobility features
Chirivi, D.; Bono, G. A.; de Keijzer, J.; Dreni, L.; Faoro, F.; Giaume, F.; Ferrandiz, C.; Fornara, F.; Betti, C.
10.1101/2025.07.06.662997 — developmental biology — Posted on 2025-07-06
1651 Extracellular RNA drives Electromethanogenesis in a Methanogenic Archaeon
Kotoky, R.; Ajunwa, O. M.; Kawaichi, S.; Meyer, R. L.; Rotaru, A.-E.
10.1101/2025.07.06.663362 — microbiology — Posted on 2025-07-06
1652 Endogenous glucocorticoids moderate the gastric inflammatory response to Helicobacter infection and protect from autoimmunity.
Druffner, S. R.; Duncan, B. C.; Morris, M. T.; Pascoe, J. L.; Abner, T. M.; Hussain, S.; Piazuelo, M. B.; Peek, R. M.; Zhang, M.; DiPaolo, R. J.; Busada, J. T.
10.1101/2025.07.03.662976 — immunology — Posted on 2025-07-06
1655 Repetition-related reductions in neural activity support improved behavior through increases in oscillatory power
Gilmore, A. W.; Claudino, L.; Levesque, C. M.; Agron, A. M.; Molfese, P. J.; Roopchansingh, V.; Rugg, M. D.; Gotts, S. J.; Martin, A.
10.1101/2025.07.06.663291 — neuroscience — Posted on 2025-07-06
1658 Cortico-striatal dynamics across working memory stages
Villet, M.; Azoulay, B.; Barik, J.; Marie, H.; Bethus, I.
10.1101/2025.07.04.663202 — neuroscience — Posted on 2025-07-06
1662 Intravital Multimodal Imaging of Human Cortical Organoids for Chronic Stroke Treatment in Mice
Wang, J.; Qiao, G.; Tan, H.; Li, M.; Wang, K.; Xu, J.; Janowski, M.; Fu, T.-M.; Walczak, P.; Liang, Y.
10.1101/2025.07.05.663297 — neuroscience — Posted on 2025-07-06
1663 Progressive Remodeling of Global Protein Interaction Networks in a Mouse Model of Tauopathy
Lin, W.; Phanse, S.; van der Spek, S.; Lampl, N.; Stephens, M. C.; Rondon Ortiz, A.; Taylor, A.; Hekman, R.; Jiang, L.; Havugimana, P.; Botas, J.; Emili, A.; Wolozin, B.
10.1101/2025.07.05.663296 — neuroscience — Posted on 2025-07-06
1665 Cerebrospinal fluid-driven ependymal motile cilia defects are implicated in multiple sclerosis pathophysiology
Bigotte, M.; Groh, A. M. R.; Afanasiev, E.; Wong, V.; Lancon, K.; Yaqubi, M.; Creeggan, F.; Moore, C. S.; Harroud, A.; Schneider, R.; Seguela, P.; Charabati, M.; Tea, F.; Fournier, A. P.; Wang, Y. C.; Ragoussis, J.; Prat, A.; Thebault, S.; Zandee, S.; Stratton, J. A.
10.1101/2025.07.06.663378 — neuroscience — Posted on 2025-07-06
1667 Discourse Focus and Memory Encoding: The Role of Trial-Level Alpha Power
Beier, E. J.; Breska, A.; Miller, L.; Oganian, Y.; Mangun, G. R.; Swaab, T. Y.
10.1101/2025.07.05.663298 — neuroscience — Posted on 2025-07-06
1668 Eccentric cycling enhances primary motor cortex excitability
Youssef, L.; O'Farrell, A.; Harroum, N.; Bakhta, Y.; Cohen, L.; Pageaux, B.; Neva, J. L.
10.1101/2025.07.04.663236 — neuroscience — Posted on 2025-07-06
1669 CloneCoordinate: Open-source software for collaborative DNA construction
Jeon, E.; Shen, Z.; Christ, S.; Qi, E.; Fan, I.; Lee, N.; Morgan, O.; Ohl, M.; Millson, D.; Laker, M.; Pierson, A.; Villegas Garcia, E.; Zhang, Y.; Choi, A.; Iyengar, A.; Kim, R.; Lee, J.; Niedeck, L.; Oeien, V.; Rashid, M.; Seetharaman, N.; Singh, A.; Soble, D.; Yu, J.; Yu, K.; Berdy, S.; Chang, E.; Kitazono, R.; Ortiz, S.; Taylor, D.; Thuronyi, B. W.
10.1101/2025.07.04.663221 — synthetic biology — Posted on 2025-07-06
1672 Secretory carrier membrane proteins assist with aquaporin trafficking in Arabidopsis.
Jiang, Q.; Vandorpe, M.; fox, a. R.; Vermeersch, M.; Mylle, E.; Cuadrado, A. F.; Kraus, J.; Liu, H.; Eeckhout, D.; Navarre, C.; Courtoy, A.; Jacobs, T. B.; Dragwidge, J. M.; De Smet, I.; Pleskot, R.; Chaumont, F.; Van Damme, D.
10.1101/2025.07.03.662988 — plant biology — Posted on 2025-07-06
1673 ERAD machinery controls the conditional turnover of PIN-LIKES in plants
Noura, S.; Ferreira Da Silva Santos, J.; Feraru, E.; Hoernstein, S. N. W.; Feraru, M. I.; Montero-Morales, L.; Roessling, A.-K.; Scheuring, D.; Strasser, R.; Huesgen, P. F.; Waidmann, S.; Kleine-Vehn, J.
10.1101/2025.07.05.663279 — plant biology — Posted on 2025-07-06
1674 Evidence for plastome loss in the holoparasitic Mystropetalaceae
Yu, R.; Jost, M.; Wanke, S.; Bruy, D.; Li, P.; Nickrent, D. L.; Zhou, R.
10.1101/2025.07.03.662983 — plant biology — Posted on 2025-07-06
1675 Multipartite coevolution shapes plant apoplastic immunity against rice blast fungus
Takeda, T.; Shimizu, M.; Kodan, A.; Utsushi, H.; Kanzaki, E.; Natsume, S.; Imai, T.; Oikawa, K.; Abe, A.; Terauchi, R.
10.1101/2025.07.03.663104 — plant biology — Posted on 2025-07-06
1692 Rad51, Rad54, and ZMM proteins antagonize the mismatch repair system to promote fertility of budding yeast intraspecies hybrid zygotes
Hung, Y.-L.; Chuang, C.-N.; Kim, H.-X.; Liu, H.-C.; Yao, J.-S.; Jovanska, L.; Hsueh, Y.-P.; Chen, R.-S.; Wang, T.-F.
10.1101/2025.02.08.636946 — genetics — Posted on 2025-07-06
1694 RBMX2: A Pivotal Regulator Linking Mycobacterium bovis Infection to Epithelial-Mesenchymal Transition and Lung Cancer Progression
Wang, C.; Peng, Y.; Yang, H.; Jiang, Y.; Khalid, A. K.; Zhang, K.; Xie, S.; Bermudez, L.; Yang, Y.; Zhang, L.; Chen, H.; Guo, A.; Chen, Y.
10.1101/2025.04.15.648920 — microbiology — Posted on 2025-07-06
1698 Population differences of chromosome 22q11.2 duplication structure predisposes differentially to microdeletion and inversion.
Porubsky, D.; Yoo, D.; Dishuck, P. C.; Koundinya, N.; Souche, E.; Harvey, W. T.; Munson, K. M.; Hoekzema, K.; Chan, D. D.; Leung, T. Y.; Santos, M. S.; Meynants, S.; Swillen, A.; Breckpot, J.; Tsapalou, V.; Hasenfeld, P.; Korbel, J. O.; Lansdorp, P. M.; Vermeesch, J. R.; Eichler, E. E.
10.1101/2025.07.04.662981 — genomics — Posted on 2025-07-05
1699 Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects
Pendyala, S.; Partington, K.; Bradley, N.; McEwen, A. E.; Straub, G.; Kim, H.-J.; Fayer, S.; Holmes, D. L.; Sitko, K. A.; Vandi, A. J.; Powell, R. L.; Friedman, C. E.; McDermot, E.; Kishore, N.; Roth, F. P.; Rubin, A. F.; Yang, K.-C.; Starita, L. M.; Noble, W. S.; Fowler, D. M.
10.1101/2025.07.03.663081 — genomics — Posted on 2025-07-05
1700 A comparison of long-read single-cell transcriptomic approaches
Scoones, A. L. A.; Lan, Y.; Utting, C.; Pouncey, L.; Lister, A.; Kudasheva, S.; Mehta, N.; Irish, N.; Swarbreck, D.; Gharbi, K.; Haerty, W.; Cribbs, A. P.; Wright, D. J.; Macaulay, I. C.
10.1101/2025.07.03.662955 — cell biology — Posted on 2025-07-05
1704 Functional insights into a peculiar tetra-modular LPMO from the human pathogen Enterobacter cloacae
Bardhan, K.; Mukherjee, S.; Vandhana, T. M.; Munzone, A.; Posbeyikian, A.; Grisel, S.; Duhsaki, L.; Berrin, J.-G.; Bissaro, B.; Madhuprakash, J.
10.1101/2025.07.04.663164 — biochemistry — Posted on 2025-07-05
1705 Interwoven DNA-MOF crystals for multi-millennial data storage
Liu, B.; Li, Z.; Li, Z.; Li, M.; Liu, Y.; Wei, Z.; Shi, Q.; Zhou, L.; Kong, H.; Xia, K.; Song, H.; Liu, X.; Fan, C.; Wang, F.
10.1101/2025.07.03.662672 — biochemistry — Posted on 2025-07-05
1706 Non-living respiration: another breath in the soil?
Bouquet, C.; Keraval, B.; Traïkia, M.; Alvarez, G.; Perriere, F.; Le Jeune, A.-H.; Billard, H.; Colombet, J.; Revaillot, S.; Fontaine, S.; Lehours, A.-C.
10.1101/2025.07.03.662961 — ecology — Posted on 2025-07-05
1708 Transient Poly(ADP-Ribose) Triggers FUS Condensation Hysteresis via a Prion-Like Mechanism
Liu, H.; Cai, Y.; Shi, L.; Pillai, M.; Das, N.; Tarbox, H. E.; Ge, Y.; Yue, K.; Yang, X.; Rath, P.; Badiee, M.; Fabilane, C. S.; Spangler, J. B.; Bedford, M. T.; Myong, S.; Fried, S. D.; Ding, X.; Leung, A. K. L.
10.1101/2025.07.03.659157 — molecular biology — Posted on 2025-07-05
1715 Ambient Proteins: Training Diffusion Models on Low Quality Structures
Daras, G.; Ouyang-Zhang, J.; Ravishankar, K.; Daspit, W.; Daskalakis, C.; Liu, Q.; Klivans, A. R.; Diaz, D. J.
10.1101/2025.07.03.663105 — bioengineering — Posted on 2025-07-05
1717 Expanding the Global Map of Protein Post Translational Modifications with Immunoaffinity Enrichment and nDIA Analysis on the Orbitrap Astral Mass Spectrometer
Kumar, M.; Possemato, A. P.; Zee, B. M.; Subramanian, S.; Ren, J. M.; Nelson, A. J.; Zhang, B.; Landry, S.; Silva, J. C.; Larsen, B.; Hart, T. P.; Stokes, M. P.; Beausoleil, S. A.
10.1101/2025.07.03.662636 — biochemistry — Posted on 2025-07-05
1718 Deciphering the Role of Acetate in Metabolic Adaptation and Drug Resistance in Non-Small Cell Lung Cancer
Maroni, G.; Cabrera San Millan, E.; Campanella, B.; Onor, M.; Cercignani, G.; Muscatello, B.; Braccini, G.; Mercatelli, R.; Chiodi, A.; Mosca, E.; Levantini, E.; Bramanti, E.
10.1101/2025.07.04.663159 — biochemistry — Posted on 2025-07-05
1726 Remodeling Activity of ChAHP Restricts Transcription Factor Access to Chromatin
Ahel, J.; Mohn, F.; Schwaiger, M.; Kaaij, L.; Steiner, J.; Moreno, E.; Hess, D.; Buhler, M.
10.1101/2025.07.03.662926 — molecular biology — Posted on 2025-07-05
1730 Mid-Infrared Photothermal Imaging of Fatty Acid Desaturation Reaction in Cancer Cells
Teng, X.; Xia, T.; Yin, J.; Li, M.; Ao, J.; Ding, G.; Prabhu Dessai, C. V.; Isac, A. M.; Matei, D.; He, H.; Cheng, J.-X.
10.1101/2025.07.02.662881 — biochemistry — Posted on 2025-07-05
1731 RNA liquid biopsy via nanopore sequencing for novel biomarker discovery and cancer early detection
Peddu, V.; Hill, A.; Velandi Maroli, S. L.; Mattingly, C.; Gardner, J. M. V.; Miga, K. H.; Fitzgerald, R. C.; Kim, D. H.
10.1101/2025.07.02.662774 — genomics — Posted on 2025-07-05
1732 Evidence supporting the first secondary chromosome in actinobacteria as a hallmark of the Embleya genus
Gomez-Escribano, J. P.; Dorai-Raj, S.; Baker, D.; Lacey, E.; Wilkinson, B.; Booth, T. J.
10.1101/2025.07.03.662523 — genomics — Posted on 2025-07-05
1733 Epigenetic adaptation of beta cells across lifespan and disease: age-related demethylation is advanced in type 2 diabetes
Manduchi, E.; Descamp, H.; Liu, J.; Schug, J.; Da, T.; Lahori, D.; El-Mekkoussi, H.; Lee, M.; Feleke, E.; Liu, C.; Naji, A.; Glaser, B.; Kaestner, K. H.; Avrahami, D.
10.1101/2025.07.02.662814 — genomics — Posted on 2025-07-05
1738 CD300e Controls Macrophage Lipid Handling and Safeguards Adipose Tissue Function in Obesity
Coletta, S.; Pizzini, S.; Vassallo, S.; Trevellin, E.; Barizza, A.; Giacometti, S.; Sales, G.; Carli, F.; Gastaldelli, A.; Vettor, R.; de Bernard, M.
10.1101/2025.07.02.662518 — immunology — Posted on 2025-07-05
1740 Comparative evaluation on the fermentative potential of single and assorted fruit and vegetable waste for production of bioethanol
Bera, S.; Kundu, S.; Mondal, S.; Bhattacharyya, S.; Banerjee, A.; Das, A.; Rahaman, T.; Ghorai, P.; De, S.; Ganguly, J.; Banik, A.; Das, M.
10.1101/2025.07.03.662480 — plant biology — Posted on 2025-07-05
1741 Nutrient excess remodels islet autonomic innervation via pancreatic schwann cells
Hampton, R.; Jimenez-Gonzalez, M.; Kang, R.; Alvarsson, A.; Espinoza, D.; Carty, J. R. E.; Seibold, F.; Lambertini, L.; Alexeyev, L.; Li, R.; Devarakonda, K.; Lu, G.; Agyapong, B.; Choudhury, J.; Krispil-Alon, M.; Scott, D. K.; Stewart, A. F.; Garcia-Ocana, A.; Stanley, S. A.
10.1101/2025.07.01.662442 — physiology — Posted on 2025-07-05
1743 Sperm hyperactivation drives a circling-and-wandering migration strategy
Zaferani, M.; Baouche, Y.; Lago-Alvarez, Y.; Pandya, A.; Cheong, S. H.; Petry, S.; Kurzthaler, C.; Stone, H. A.
10.1101/2025.07.03.662809 — biophysics — Posted on 2025-07-05
1744 In Situ Inference of Copy Number Variations in Image-Based Spatial Transcriptomics
Jensen, A. E. V.; Crowell, H.; Pascual Reguant, A.; Ruano, I.; Tejpar, S.; Heyn, H.; Nilsson, M.; Marco Salas, S.
10.1101/2025.07.02.662761 — bioinformatics — Posted on 2025-07-05
1745 OMIDIENT: Multiomics Integration for Cancer by Dirichlet Auto-Encoder Networks
Safinianaini, N.; Valimaki, N.; Bresson, R.; Gorbonos, A.; Rajamaki, K.; Aaltonen, L. A.; Marttinen, P.
10.1101/2025.07.02.662608 — bioinformatics — Posted on 2025-07-05
1746 Screening of a pooled library of chimeric antigen receptor T cells based on secretory function
Soemardy, C.; Mei, A.; Castellanos-Rueda, R.; Espinoza, N. G.; Kizerwetter, M.; Spangler, J. B.; Reddy, S. T.; Di Carlo, D.
10.1101/2025.07.02.662376 — bioengineering — Posted on 2025-07-05
1748 Long-acting hydrogel-based depot formulations of tirzepatide and semaglutide for the management of type 2 diabetes and weight
d'Aquino, A. I.; Dong, C.; Nguyen, L. T.; Yan, J.; Jons, C. K.; Saouaf, O. M.; Song, Y. E.; Eckman, N.; Kapasi, S.; Williams, C. M.; Doulames, V. M.; Sen, S.; Manna, M. K.; Alakesh, A.; Lu, K.; Hall, I.; Appel, E. A.
10.1101/2025.07.02.662867 — bioengineering — Posted on 2025-07-05
1750 De novo design of high-affinity miniprotein binders targeting Francisella tularensis virulence factor
Gokce-Alpkilic, G.; Huang, B.; Liu, A.; Kreuk, L. S. M.; Wang, Y.; Adebomi, V.; Bueso, Y. F.; Bera, A.; Kang, A.; Gerben, S. R.; Rettie, S.; Vafeados, D. K.; Roullier, N.; Goreshnik, I.; Li, X.; Baker, D.; Woodward, J. J.; Mougous, J. D.; Bhardwaj, G.
10.1101/2025.07.02.662053 — biochemistry — Posted on 2025-07-05
1752 Can music modulate gene expression involved in traumatic brain injury? An integrative transcriptomic and epigenomic proof of concept
Gomez-Carballa, A.; Pischedda, S.; Mallah, N. E. Z.; Nowak, W. D.; Martinon-Torres, F.; Navarro, L.; Salas, A.
10.1101/2025.07.02.662815 — genomics — Posted on 2025-07-05
1755 A deep population stratification and ongoing local adaptations of the range-expanding lovebug Plecia longiforceps
Kim, D.; Choi, J.; Kim, D.; Cossette, M.-L.; Kim, S.; Tsai, C.-L.; Baek, M. J.; Park, S.-J.; Borzee, A.; Shin, S.; Jeong, C.
10.1101/2025.07.02.662813 — evolutionary biology — Posted on 2025-07-05
1756 Structural similarities reveal an expansive conotoxin family with a two-finger toxin fold
Khilji, M. S.; Hackney, C. M.; Koch, T. L.; Hone, A. J.; Rogalski, A.; Watkins, M.; Tun, J.; McIntosh, J. M.; Olivera, B.; Safavi-Hemami, H.; Teilum, K.; Ellgaard, L.
10.1101/2025.07.03.662903 — evolutionary biology — Posted on 2025-07-05
1757 Genetic mapping in the red mason bee Osmia bicornis implicates ANTSR as an ancient sex-determining locus in bees and ants
Rönneburg, T.; Taliadoros, D.; Olsson, A.; Magnusson, S.; Huser, L.; Fuad, M. N. I. B. N.; Everitt, T.; Martin-Hernandez, G. C.; Cederberg, B.; Paxton, R.; Seidelmann, K.; Webster, M. T.
10.1101/2025.07.03.662907 — evolutionary biology — Posted on 2025-07-05
1760 PDL1 CHECKPOINT BLOCKADE SYNERGIZES WITH NILOTINIB BUT NOT DASATINIB TO PREVENT LEUKEMIA RELAPSE
Morgan, E. C.; Venkatesh, H.; Centenos, E. G.; Heltemes-Harris, L. M.; Hubbard, G.; Maiers, T. L.; Dileepan, T.; Tracy, S. I.; Farrar, M. A.
10.1101/2025.07.02.662848 — immunology — Posted on 2025-07-05
1761 Peripheral T Helper Cells Dominate the Synovial CD4⁺ T Cell Compartment in Systemic Juvenile Idiopathic Arthritis and Are Shaped by IL-1β and IL-18
Dirks, J.; Fischer, J.; Harrer, L.; Bracaglia, C.; Prencipe, G.; Pardeo, M.; Magni-Manzoni, S.; Caiello, I.; Holl Wieden, A.; Girschick, H.; Kessel, C.; Morbach, H.
10.1101/2025.07.03.661735 — immunology — Posted on 2025-07-05
1766 Extracorporeal Placental Support in a Sheep's Gravid Uterus
Salazar, J. H.; Schuh, J. M.; Morelos, A.; Monroy, I.; Abebrese, E.; Stocke, N.; Starkey, N.; Jones, D.; Konduri, G. G.
10.1101/2025.07.02.662865 — physiology — Posted on 2025-07-05
1767 Aerobic scope is sustained through a heatwave in juvenile Atlantic salmon
Cotgrove, L.; Morozov, S.; Raitakivi, M.; Sala, E.; Prokkola, J. M.
10.1101/2025.07.03.662906 — physiology — Posted on 2025-07-05
1768 Preclinical Study of Cannflavins A and B Action Against Glioblastoma Cells
Holborn, J.; Robeson, H.; Chartley, E.; Gluscevic, T.; Borenstein, A.; Perrin, C.; Alural, B.; Perera, H.; Akhtar, T. A.; Jones, N.; Lalonde, J.
10.1101/2025.07.02.662823 — pharmacology and toxicology — Posted on 2025-07-05
1769 Large Language Model Agent for Modular Task Execution in Drug Discovery
Ock, J.; Meda, R. S.; Badrinarayanan, S.; Aluru, N. S.; Chandrasekhar, A.; farimani, A. B.
10.1101/2025.07.02.662875 — pharmacology and toxicology — Posted on 2025-07-05
1771 Copper-Containing ROS-Scavenging Nanozyme Paradoxically Drives Alpha-Synucleinopathy by Amplifying Nitrosative Stress
Li, S.; Mao, Y.; Wang, N.; Zhang, J.; Zhi, X.; Chen, Y.; Si, J.; Yang, Q.; Kumbhar, R.; Joeng, D.; Song, J.-Y.; Yang, X.; Kang, B. G.; Khandekar, A.; Park, J.; Gao, Y.; Yu, S.; Chen, R.; Zhang, S.; Han, J.; Dawson, V. L.; Liu, P.; Han, S.; Dawson, T.; He, W.; Mao, X.
10.1101/2025.07.01.661317 — pathology — Posted on 2025-07-05
1772 Cannabidiol (CBD) as a novel inhibitor of HLA-G expression in human choriocarcinoma cell line (JEG-3)
Martinez, K. I.; Palma, M. B.; Sepulveda, F. J.; Moavro, D. E.; Carosella, E. D.; Garcia, M. N.; Riccillo, F. L.
10.1101/2025.07.02.662795 — cancer biology — Posted on 2025-07-05
1776 Mechanistic modeling and machine learning identifies optimum radiotherapy schedules to prevent treatment-induced metastasis
Graser, C.; Zhou, Z.; Schürch, M.; Moorhead, G.; Dean, J.; Lin, C.; Dean, J.; Kozono, D.; Lahav, G.; Michor, F.
10.1101/2025.07.02.662373 — bioinformatics — Posted on 2025-07-05
1780 Scale-Specific Viscoelastic Characterization of Hydrogels: Integrated AFM and Finite Element Modeling
Fertala, N.; Uhlmann, K.; Grigoryev, E.; Seth, P.; Friedrichs, J.; Werner, C.; Balzani, D.
10.1101/2025.07.02.662292 — bioengineering — Posted on 2025-07-05
1782 Phased affinity-controlled delivery of vascular endothelial growth factor, fibroblast growth factor-2, and platelet derived growth factor enhances in vitro angiogenesis
Svendsen, J. E.; Asnes, C. L.; Nightheart, S. R.; Ford, M. R.; Hajarizadeh, A.; Oh, S. C.; Hochstatter, H. B.; O'Hara-Smith, J. R.; Guldberg, R. E.; Hettiaratchi, M. H.
10.1101/2025.07.01.662647 — bioengineering — Posted on 2025-07-05
1783 A Compact Two-Photon Module for Simultaneous Dual-Depth, Multi-Region in vivo Brain Imaging
Zhao, Y.; Gu, X.; Kong, C.; Liu, S.; Zhu, Y.; Su, J.; Wu, J.; Xu, F.; Chen, L.; Mao, Y.; Li, B.
10.1101/2025.07.02.662755 — bioengineering — Posted on 2025-07-05
1785 Genetic affinities between an ancient Greek colony and its metropolis: the case of Amvrakia in western Greece
Psonis, N.; Tabakaki, E.; Vassou, D.; Papadantonakis, S.; Souleles, A.; Nafplioti, A.; Kousis Tsampazis, G.; Papadopoulou, A.; Xanthopoulos, K.; Panailidis, P.; Georgiadou, A.; Papakosta, D.; Koursioti, S.; Evangelinou, M.; Papadopoulou, V.; Evaggeloglou, P.; Korka, E.; Christidis, I.; Ioannou, M.; Kontogianni, T.; Arkoumanis, A.; Stamatakis, A.; Poulakakis, N.; Papageorgopoulou, C.; Pavlidis, P.
10.1101/2025.07.01.662689 — evolutionary biology — Posted on 2025-07-05
1786 Establishment, conservation, and innovation of dorsal determination mechanisms during the evolution of vertebrate paired appendages
Hawkins, M. B.; Zdral, S.; Naranjo, S.; Julia, M.; Sanchez-Martin, M.; Daane, J. M.; Cumplido, N.; Jandzik, D.; Medeiros, D. M.; McMenamin, S.; Harris, M. P.; Tena, J. J.; Ros, M.
10.1101/2025.07.02.662459 — evolutionary biology — Posted on 2025-07-05
1787 Contemporary hybridization among Arabis floodplain species creates opportunities for adaptation
Rahnamae, N.; Metzger, L.; Hoerdemann, L.; Korfmann, K.; Khan, A. S.; Dent, C. I.; Amar, S.; Wijfjes, R.; Ali, T.; Schmitz, G.; Stich, B.; Tellier, A.; de Meaux, J.
10.1101/2025.07.03.662201 — evolutionary biology — Posted on 2025-07-05
1793 DNA-protein interactions in Meloidogyne incognita
Bournaud, C.; Tollec, A.; Danchin, E. G. J.; Coute, Y.; Eves-van den Akker, S.
10.1101/2025.07.02.662738 — molecular biology — Posted on 2025-07-05
1794 REGULATORY T CELLS PROTECT AGAINST ABERRANT REMODELING IN A MOUSE MODEL OF PULMONARY FIBROSIS
Murthy, A.; Rodriguez, L. R.; Barboza, W. R.; Tomer, Y.; Bui, S.; Carson, P.; Dimopoulos, T.; Iyer, S.; Chavez, K.; Cooper, C. H.; Katzen, J. B.; Beers, M. F.
10.1101/2025.07.02.662777 — molecular biology — Posted on 2025-07-05
1795 Pulmonary macrophage subsets display distinct metabolic responses to polarising stimuli in vivo
Hughes, J. J.; Colombo, S. A.; Booty, L.; Ridley, A. J.; Harrop, B. J.; Mallet, G.; Argüello, R. J.; Phythian-Adams, A.; MacDonald, A. S.
10.1101/2025.07.02.662727 — immunology — Posted on 2025-07-05
1796 T cell AIM2 Exacerbates Lung Inflammation in OVA-LPS and HDM-induced Asthma Models
Chou, W.-C.; Hsu, M.; Jania, C. M.; Guthrie, E. H.; Wrobel, J. A.; Liang, K.; Livraghi-Butrico, A.; Tilley, S. L.; Wan, Y.; Ting, J. P.- Y.
10.1101/2025.07.02.662837 — immunology — Posted on 2025-07-05
1797 Common Signatures of Neutrophils in Diverse Disease Conditions
Wu, D.; Cao, Y.; Chen, H.; Du, M.; Wang, T.; Zhao, J. Z.; Li, M.; Wu, W.; Zhang, H.; Yang, E.; Yang, J.; Chen, J.
10.1101/2025.07.02.662891 — immunology — Posted on 2025-07-05
1798 SHIP1 regulates TREM2 signalling and macrophage functions in a hiPSC-derived model
Martin, C. S.; Obst, J.; Ibarra, S.; Murphy, E.; Gospodinova, K. O.; Mead, E.
10.1101/2025.07.02.662745 — immunology — Posted on 2025-07-05
1802 Prenatal cannabis smoke exposure alters placental development in a murine model of pregnancy
Podinic, T.; Sunil, M.; MacAndrew, A.; Monaco, C.; Lee, G.; Lockington, C.; Lucas, A.-M.; Tomy, T.; Kasinska, J.; Jamshed, L.; Holloway, A.; Petrik, J.; Tomy, G.; Ratcliffe, E.; Raha, S.
10.1101/2025.06.28.662155 — physiology — Posted on 2025-07-05
1803 Morning Elevation in Insulin Enhances Afternoon Postprandial Insulin Action and Glucose Effectiveness
Waterman, H. L.; Smith, M.; Farmer, B.; Yankey, K.; Howard, T.; Kraft, G.; Cherrington, A.; Edgerton, D.
10.1101/2025.07.01.662587 — physiology — Posted on 2025-07-05
1805 Liver Kinome Profiling Identifies PS1145 as a Potential Therapeutic molecule for amelioration of Systemic Inflammation in Alcohol-related Liver Disease
Maras, J. S.; Yadav, M.; Gupta, A. c.; Rao, S.; Sharma, V.; Magar, Y.; Deepanshu, D.; Khan, T.; SHARMA, N.; Yadav, K.; Sharma, N.; Bindal, V.; Pandey, S.; Tripathi, G.; Saif, R.; Mathew, B.; Tripathi, D. M.; Parasar, A.; Sarin, S. K.
10.1101/2025.07.02.662754 — pharmacology and toxicology — Posted on 2025-07-05
1806 Spatial and spectral mapping of traffic-related air pollution (TRAP) nanoparticles in relation to plaques and inflammatory markers in an Alzheimer disease model
O'Toole, H. J.; James, A.; Nasim, N.; Hadley, D. J.; Hale, E. J.; He, Q.; Bein, K. J.; Valenzuela, A. E.; Rojalin, T.; Dugger, B. N.; Wexler, A. S.; Lein, P. J.; Carney, R. P.
10.1101/2025.07.01.662638 — pharmacology and toxicology — Posted on 2025-07-05
1807 The PTPN1 and PTPN2 phosphatases are Cooperative Regulators of Cancer Cell Immune Evasion
Poirier, A.; Walback, E.; Su, R.; Aubry, I.; Wu, C.; St-Laurent, E.; Uttam, S.; Hincapie, A. M.; Colalillo, B.; Hardy, S.; Dore, S.; Tremblay, M. L.
10.1101/2025.07.02.662801 — cancer biology — Posted on 2025-07-05
1808 Labile iron pool dynamics do not drive ferroptosis potentiation in colorectal cancer cells
Ponnusamy, V.; Randall, D. R.; Lee, Z.; Das, N. K.; Zhao, L.; Buscher, K.; Solanki, S.; Renslo, A.; Shah, Y. M.; Hsu, P. P.
10.1101/2025.07.01.662602 — cancer biology — Posted on 2025-07-05
1812 PULPO: Pipeline of understanding large-scale patterns of oncogenomic signatures
Portasany-Rodriguez, M.; Soria-Alcaide, G.; G.Sanchez, E.; Ivanova, M.; Gomez, A.; Gimenez, R.; Lalchandani, J.; Garcia-Aguilera, G.; Aleman-Arteaga, S.; Saiz-Ladera, C.; Ramirez-Orellana, M.; Garcia-Martinez, J.
10.1101/2025.07.02.661487 — bioinformatics — Posted on 2025-07-05
1816 Optical Coherence Tomography with Fluorescein Optical Clearing for Transscleral Image Guidance
Trout, R. M.; Narawane, A.; Viehland, C.; Ownagh, V.; Draelos, M.; Dhalla, A.-H.; Kuo, A.; Toth, C.
10.1101/2025.07.01.661162 — bioengineering — Posted on 2025-07-05
1818 Buffer Valency Engineering Enables High-concentration and Shelf-stable DNA Transfection Particles for Viral Vector Production
Lin, J.; Hu, Y.; Pial, T. H.; Goodier, K. D.; Yu, D.; Guise, M.; Brailsford, P.; Choi-Ali, M.; Li, S.; Zhu, Y.; Ma, J.; Cheng, L.; Lu, X.; Korinetz, N.; Wang, J.; Curk, T.; Mao, H.-Q.
10.1101/2025.07.02.662322 — biochemistry — Posted on 2025-07-05
1821 KIMMDY: a biomolecular reaction emulator
Hartmann, E.; Buhr, J.; Riedmiller, K.; Ulanov, E.; Schuepp, B.; Kiesewetter, D.; Sucerquia, D.; Aponte-Santamaria, C.; Graeter, F.
10.1101/2025.07.02.662624 — biochemistry — Posted on 2025-07-05
1822 Socioeconomic predictors of knockdown resistance in Aedes albopictus (Diptera: Culicidae)
Butler, C. D.; Ding, J. Y.; Baltzegar, J. F.; Brown, Z. S.; Burford Reiskind, M. O.; Reiskind, M. H.
10.1101/2025.07.01.662680 — evolutionary biology — Posted on 2025-07-05
1826 Feeding activity of soil oligochaetes under different soil moisture regimes assessed by the bait-lamina test.
Dell'Ambrogio, G.; Campiche, S.; Wong, J. M. Y.; Renaud, M.; Lüthi, C.; Werner, I.; Ferrari, B. J. D.
10.1101/2025.07.02.662706 — ecology — Posted on 2025-07-05
1827 CASZ1 regulates the rate at which outer hair cells mature and is required for hearing
Nakano, Y.; Driver, E. C.; Wiechert, S. C.; Peguero, B.; Boger, E. T.; Allamargot, C.; Hipp, R.; Doetzlhofer, A.; Morell, R. J.; Kelley, M. W.; Banfi, B.
10.1101/2025.07.04.663233 — developmental biology — Posted on 2025-07-05
1828 The ParA-like ATPase PldP influences the TatA dynamics in Corynebacterium glutamicum
Karnaukhova, E.; Alwardt, D.; Böhm, K.; Weiss, M.; Meyer, F. M.; Giacomelli, G.; Mehner-Breitfeld, D.; Brüser, T.; Bramkamp, M.
10.1101/2025.07.02.662783 — microbiology — Posted on 2025-07-05
1829 Stable coexistence of Citrobacter rodentium with a lytic bacteriophage during in vivo murine infection
Frankel, G.; Peters, A.; Shareefdeen, H.; Sanchez-garrido, J.; Chohen, E.; Denise, R.; Wong, J.; Beeby, M.; Hill, C.
10.1101/2025.07.03.662908 — microbiology — Posted on 2025-07-05
1831 Differential Assembly of Mouse and Human Tumor Microenvironments
Courau, T.; Jaszczak, R. G.; Samad, B.; Flynn, E.; Reeder, G. C.; Chew, N. W.; Tsui, J.; Ray, A.; Wismer, H.; Bunis, D.; Lupin-Jimenez, L.; Gavil, N. V.; Masopust, D.; Graham, J. P.; Skelly, D. A.; Vesco, X.; Liu, E. T.; Fragiadakis, G. K.; Combes, A. J.; Krummel, M. F.
10.1101/2025.07.01.661217 — immunology — Posted on 2025-07-05
1834 Electrocorticographic Detection of Speech Networks in Glioma-infiltrated Cortex
Ambati, V. S.; Persad, A. S.; Kaur, J.; Herr, S.; Cunningham, E.; Dada, A.; Ekert, J. O.; Greicius, Q.; Silva, A.; McMillan Villalobos, P.; Olshausen, N.; Sibih, Y.; Oten, S.; Yamada, H. S.; Umbach, G.; Aabedi, A. A.; Al-Holou, W.; Young, J.; Sushil, M.; Chang, E. F.; Berger, M. S.; Brang, D.; Hervey-Jumper, S. L.
10.1101/2025.07.04.663249 — neuroscience — Posted on 2025-07-05
1835 Seed fossil record of Solanaceae revisited
Deanna, R.; Hvalj, A. V.; Martinetto, E.; Knapp, S.; Sadowski, E.-M.; Manchester, S.; Campos, A.; Fernandez, V.; Barboza, G. E.; Sauquet, H.; Dean, E.; Sarkinen, T.; Chiarini, F. E.; Bernardello, G.; Smith, S. D.
10.1101/2025.07.03.662944 — paleontology — Posted on 2025-07-05
1838 Nuclear Myosin 1 links genomic architecture to adipose tissue remodeling, metabolic inflammation and obesity in mice
Khalaji, S.; Venit, T.; Lukacova, Z.; Fambri, V.; Shrestha, R.; Kaluarachchi, S.; Boitet, M.; Fagny, M.; Saldi, G.; Percipalle, P.
10.1101/2025.06.30.662298 — cell biology — Posted on 2025-07-05
1840 Progressive Supranuclear Palsy PERK haplotype B selectively translates DLX1 promoting tau toxicity
Lessard, C. B.; Rubio-Rubio, D.; Tolton, S.; Criado-Marrero, M.; Ravi, S.; Garza, T. N.; Koren, J.; Phillips, J.; Bagchi, P.; McFarland, K. N.; Chhangani, D.; Golde, T.; Giasson, B. I.; Lewis, J.; Chakrabarty, P.; LaVoie, M. J.; Borchelt, D. R.; Seyfried, N. T.; Prokop, S.; Rincon-Limas, D. E.; Abisambra, J.
10.1101/2025.06.30.662315 — neuroscience — Posted on 2025-07-05
1842 Integrated landscape genomics reveals biogeography and climate-driven local adaptation in high-altitudes
Wang, N.; Ghimire, P.; Chhetri, P.; Ghimire, N.; Yi, C.; Zhang, T.; Zhuoga, S.; Jiangyong, Z.; Lamichhaney, S.
10.1101/2025.07.02.662798 — evolutionary biology — Posted on 2025-07-05
1845 Two parallel lineage-committed progenitors contribute to the developing brain
Dundes, C. E.; Jokhai, R. T.; Ahsan, H.; Kang, R. S.; Salomon-Shulman, R. E. A.; Rajan, A.; Kim, Y. S.; Stanton, L. J.; Xu, C.; Do, S.; McDonald, B. D.; Lopez, J. M. A.; Urrutia, H. A.; Greenfeld, H.; Wong, A.; Qu, Y.; Petkovic, A. S.; Miao, Y.; Garcia, K. C.; Monje, M.; Wagner, D. E.; Bronner, M. E.; Lowe, C. J.; Loh, K. M.
10.1101/2025.07.02.662771 — developmental biology — Posted on 2025-07-05
1846 Extracting Reproducible Components from Electroencephalographic Responses to Transcranial Magnetic Stimulation with Group Task-Related Component Analysis
Couto, B. A. N.; Fecchio, M.; Russo, S.; De Martino, E.; Parmigiani, S.; Sarasso, S.; Graven-Nielsen, T.; de Andrade, D. C.; Massimini, M.; Rosanova, M.; Casali, A. G.
10.1101/2025.06.02.657489 — neuroscience — Posted on 2025-07-05
1847 Multi-task machine learning reveals the functional neuroanatomy fingerprint of mental processing
Wang, Z.; Chen, Y.; Yan, J.; Pan, Y.; Mao, W.; Xiao, Z.; Cao, G.; Toussaint, P.-J.; Guo, W.; Zhao, B.; Sun, H.; Zhang, T.; Evans, A. C.; Jiang, X.
10.1101/2023.11.30.569385 — neuroscience — Posted on 2025-07-05
1848 Two residues reprogram immunity receptor kinases to signal in nitrogen-fixing symbiosis
Tsitsikli, M.; Simonsen, B. W.; Luu, T.-B.; Larsen, M. M.; Andersen, C. G.; Gysel, K.; Lironi, D.; Kronauer, C.; Rubsam, H.; Hansen, S. B.; Baerentsen, R.; Wulf, J. L.; Johansen, S. H.; Kaya, G.; Stougaard, J.; Andersen, K. R.; Radutoiu, S.
10.1101/2024.08.22.609144 — plant biology — Posted on 2025-07-05
1849 Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1
Thatavarthy, S.; Abriata, L.; Meireles, F.; Zuccaro, K. E.; Iragavarapu, A. G.; Sullivan, G. M.; Moss, F. R.; Frost, A.; Dal Peraro, M.; Aydin, H.
10.1101/2024.05.21.595226 — biophysics — Posted on 2025-07-05
1850 Assembly of Macromolecular Complexes in the Whole-Cell Model of a Minimal Cell
Fu, E.; Thornburg, Z. R.; Brier, T. A.; Wei, R.; Bo, Y.; Gilbert, B. R.; Wang, S.; Luthey-Schulten, Z.
10.1101/2025.07.02.662439 — biophysics — Posted on 2025-07-05
1852 Direct from the Seed: An Atomic-Resolution Protein Structure by Ab Initio MicroED
Vasireddy, P. C. R.; Low-Beer, T.; Spoth, K. A.; Acehan, D.; Crawley, M. R.; Martynowycz, M. W.
10.1101/2025.07.03.663097 — biophysics — Posted on 2025-07-05
1854 Spread of a single superclone drives insecticide resistance in Acyrthosiphon kondoi across an invasive range
Thia, J. A.; Hunt, B. J.; Wang, S.; Troczka, B. J.; Chirgwin, E.; Brown, C. J.; Sakamoto, R.; Stelmach, M.; Richardson, K.; Arinanto, L. S.; Dorai, A. P.; Joglekar, C.; Yang, Q.; Babineau, M.; Bass, C.; Umina, P. A.; Hoffmann, A. A.
10.1101/2024.12.16.628636 — evolutionary biology — Posted on 2025-07-05
1855 Environmental controls on crenarchaeol distributions in hydrothermal springs
Calhoun, A. N.; Blewett, J.; Colman, D.; Amenabar, M. J.; Harris, C. M.; Boyd, E.; Pearson, A.; Leavitt, W. D.
10.1101/2024.07.09.602736 — microbiology — Posted on 2025-07-05
1856 Strengthening Medial Olivocochlear Feedback Reduces the Developmental Impact of Early Noise Exposure
Castagna, V. C.; Boero, L. E.; Di Guilmi, M. N.; Catalano Di Meo, C.; Ballestero, J. A.; Fuchs, P. A.; Lauer, A. M.; Elgoyhen, A. B.; Gomez-Casati, M. E.
10.1101/2025.01.03.631257 — neuroscience — Posted on 2025-07-05
1857 Cortex-Wide, Cellular-Resolution Volumetric Imaging with a Modular Two-Photon Imaging Platform
Hu, J.; Zhu, Y.; Liu, S.; Li, C.; Zhang, M.; Gu, X.; Wu, J.; Xu, F.; Mao, Y.; Li, B.
10.1101/2025.07.03.662899 — neuroscience — Posted on 2025-07-05
1859 Ligand-dependent G protein dynamics underlying opioid signaling efficacy
Deutsch, J.; Hilger, D.; Janetzko, J.; Schroeder, C. M.; Chu, S.; Kobilka, B.; Shivnaraine, R. V.
10.1101/2025.06.30.662233 — biophysics — Posted on 2025-07-05
1863 Cannibalism Shapes Biofilm Structure and Composition in Bacillus subtilis
Friebel, L.; Knepper, J.-P.; Becker, N. S.; Abbaszade, G.; Stueckrath, K.; Soltwisch, J.; Mueller, S.; Dreisewerd, K.; Mascher, T.
10.1101/2025.03.21.644447 — microbiology — Posted on 2025-07-05
1867 High-performance genetically-encoded green and red fluorescent biosensors for pyruvate
Imai, S.; Hario, S.; Suerte, C.; Yamaguchi, I.; Sakoi, K.; Thuen, A.; Meznarich, B.; Drobizhev, M.; Terai, T.; Takahashi-Yamashiro, K.; Campbell, R. E.
10.1101/2025.04.17.649293 — molecular biology — Posted on 2025-07-05
1868 The effect of environmental enrichment on immune cell DNA methylation profiles depends on the parity of sows.
Lopes, M. M.; Monteiro Moreira, G. C.; Chaulot-Talmon, A.; Frambourg, A.; Costes, V.; Demars, J.; MERLOT, E.; JAMMES, H.
10.1101/2025.07.01.662510 — genomics — Posted on 2025-07-04
1870 Thermogenic Adipose ADH5 Counteracts Age-related Metabolic Decline
Sebag, S. C.; Neff, T.; Qian, Q.; Asghari, A.; Wang, Z.; Zhang, Z.; Li, M.; Hao, M.; Lira, V.; Sun, H.; Potthoff, M. J.; Yang, L.
10.1101/2025.07.01.662628 — physiology — Posted on 2025-07-04
1873 Multi-omics integration uncovers host-microbiota crosstalk underlying sexual differentiation in the shortfin eel Anguilla bicolor pacifica
Brandon-Mong, G.-J.; Lee, T.-H.; Chen, Y.-L.; Hsiao, T.-H.; Wu, G.-L.; Lai, Y.-L.; Weng, C.-Y.; Gicana, R. G.; Yen, Y.-T.; Xu, Y.-F.; Wang, T.-Y.; Chiang, Y.-R.
10.1101/2025.07.03.663112 — microbiology — Posted on 2025-07-04
1874 Keratin degradation reflects a starvation survival strategy in Fervidobacterium islandicum AW-1
Lee, D.-W.; Sung, J.-Y.; Kim, J.-Y.; Jin, H.-S.; Baek, J.-H.; Kim, N. E.; Song, H. H.; Bong, S.-H.; Lee, Y.-J.; Kim, B.-C.; Lee, D. Y.
10.1101/2025.07.04.663136 — microbiology — Posted on 2025-07-04
1875 Inhibition of NLRP3 by a CNS-penetrating indazole scaffold
Torp, J.; Ferber, D.; Buthmann, H.; Hagelueken, G.; Deshpande, A.; Hartman, G.; Hughes, R. E.; Salazar, T.; Tronnes, S.; Duisembekova, A.; Marleaux, M.; Hochheiser, I. V.; Coll, R. C.; Montgomery, R.; Fortney, K.; Py, B. F.; Wilhelmsen, K.; Geyer, M.
10.1101/2025.07.01.662566 — immunology — Posted on 2025-07-04
1876 Two closed systems for long-term propagation of the marine tunicate Botryllus schlosseri isolated from natural seawater
Hamar, J. C.; Dong, W.; Luu, B.; Lin, M.; Enriquez, I.; Lepretre, M.; Gardell, A. M.; Rinkevich, B.; Kültz, D.
10.1101/2025.07.01.662663 — zoology — Posted on 2025-07-04
1882 Mesoscale Transport of Enveloped Viruses
Moreno-Chaparro, D.; Balboa Usabiaga, F.; Ellero, M.; Moreno, N.
10.1101/2025.07.02.662892 — biophysics — Posted on 2025-07-04
1883 mRNA interactions promote cotranslational association of heteromeric membrane proteins
Flores-Aldama, L.; Hoth, A. S.; de Carvalho, L.; Seim, I.; Gladfelter, A. S.; Robertson, G.
10.1101/2025.07.01.662506 — biophysics — Posted on 2025-07-04
1885 An Intrinsic-hoc Framework for Heterogeneous Cellular Senescence Elucidation Using Deep Graph Representation Learning and Experimental Validation
Ma, A.; Cheng, H.; Vanegas, N. D. P.; Ghobashi, A.; Chen, H.; Rodriguez, J.; Rosas, L.; Wang, C.; Shao, J.; Jiang, Y.; Wang, X.; Rahman, I.; Lugo-Martinez, J.; Li, D.; Pryhuber, G. S.; Bar-Joseph, Z.; Eickelberg, O.; Konigshoff, M.; Chung, D.; Chen, R.; Finkel, T.; Mora, A.; Rojas, M.; Ma, Q.
10.1101/2025.07.01.662364 — bioinformatics — Posted on 2025-07-04
1887 Automodification of N-terminal serine residues in PARP2 impacts PARP2 release from DNA damage sites
Dhakar, S. S.; Galera-Prat, A.; Cai, J.; Preisser, J.; Kiema, T.-R.; Ladurner, A.; Lehtiö, L.
10.1101/2025.07.01.662498 — biochemistry — Posted on 2025-07-04
1889 PGM1 deficiency disrupts sarcomere and mitochondrial function in a stem-cell cardiomyocyte model
Radenkovic, S.; Preston, G.; Budhraja, R.; Muffels, I.; Ligezka, A. N.; Hrstka, R.; Staff, N. P.; Balakrishan, B.; Shah, R.; Verberkmoes, S.; Shammas, I.; Bosnyak, I.; Stiers, K. M.; Lai, K.; Beamer, L. J.; Pandey, A.; Morava, E.; Kozicz, T.
10.1101/2025.07.01.662580 — biochemistry — Posted on 2025-07-04
1892 Gamete release in Ciona robusta: roles of gonadotropin-releasing hormone and the photoreception system
Osugi, T.; Matsubara, S.; Shiraishi, A.; Wada, A.; Miyamoto, Y.; Shimada, I. S.; Sasakura, Y.; Kusakabe, T. G.; Satake, H.
10.1101/2025.07.01.661410 — evolutionary biology — Posted on 2025-07-04
1895 ZFHX4 is necessary for dopaminergic neuron differentiation and controls cell cycle by regulating LIN28A
Valceschini, E.; Gomez-Ramos, B.; Ohnmacht, J.; Ginolhac, A.; Catillon, M.; Gerard, D.; Gaigneaux, A.; Kyriakis, D.; Grzyb, K.; Glaab, E.; Grunewald, A.; Skupin, A.; Sauter, T.; Kruger, R.; Sinkkonen, L.
10.1101/2025.07.03.662987 — molecular biology — Posted on 2025-07-04
1897 Linking genomic evolutionary transitions to ecological phenotypic adaptations in Spirochaetes
HUETE, S. G.; COULLIN, K.; CHAPEAUBLANC, E.; TORCHET, R.; BENAROUDJ, N.; PICARDEAU, M.
10.1101/2025.07.04.663154 — microbiology — Posted on 2025-07-04
1898 Variability in intrinsic drug tolerance in Mycobacterium tuberculosis corresponds with phylogenetic lineage
March, V. F. A.; Zwyer, M.; Loiseau, C.; Brites, D.; Goig, G. A.; Bouaouina, S.; Dötsch, A.; Reinhardt, M.; Kalkan, S.; Gagneux, S.; Borrell Farnov, S.
10.1101/2025.07.04.663131 — microbiology — Posted on 2025-07-04
1903 Immune-deficient bacteria serve as gateways to genetic exchange and microbial evolution
Figueroa, W.; Sabnis, A.; Ibarra-Chavez, R.; Gorzynski, J.; Fitzgerald, R.; Penades, J. R.
10.1101/2025.07.04.663135 — microbiology — Posted on 2025-07-04
1904 Tmem127-mediated immune receptor degradation regulates T cell homeostasis through the common gamma chain
Hasiuk, M.; Negraschus, A.; Seyres, D.; Marone, R.; Jankevicius, G.; Siewert, L.; Schultheiss, C.; Blazquez, A. M.; Binder, M.; Proebstel, A.-K.; Hiller, S.; Heissmeyer, V.; Jeker, L. T.
10.1101/2025.07.01.662281 — immunology — Posted on 2025-07-04
1906 Establishment of menthol bleaching protocols for six stony coral species
Bauer, L.; Ferrara, E. F.; Puntin, G.; Paulus, A.-L.; Reiser, M.; Schmidt, F.; Zeh, M.; Ziegler, M.
10.1101/2025.07.01.662491 — systems biology — Posted on 2025-07-04
1907 DIFFERENTIAL ROLES OF RAD18 IN REPRESSING CARCINOGEN- AND ONCOGENE-DRIVEN MUTAGENESIS IN VIVO
Anand, J.; Brown, B. W.; Lou, J.; Gu, Q.; Yang, Y.; Droby, G. N.; Wu, D.; Jena, A.; Xie, J.; Fedoriw, Y.; Weissman, B.; Williams, S. E.; Vaziri, C.
10.1101/2025.06.30.662411 — cancer biology — Posted on 2025-07-04
1908 Rapid Assessment of Size, Shape, and Chemical Complementarity of Ligands for Computational Protein Design
Petrenas, R.; Ozga, K.; Chubb, J. J.; Romanyuk, A. V.; McManus, J. J.; Leggett, G. J.; Scrutton, N. S.; Oliver, T. A. A.; Woolfson, D. N.
10.1101/2025.06.30.662286 — biophysics — Posted on 2025-07-04
1910 Construction of recombinant Bacillus subtilis spores surface-displaying PRRSV ORF1b, GP5, M, and N proteins in tandem and evaluation of their immunogenicity in mice
Yang, Y.; Li, J.; Fang, P.; Chen, B.; Tang, Y.; Dai, X.; Fei, L.; Xiao, Y.; Shi, C.; Dong, Y.; Ni, X.; Jing, B.; Zen, Y.; PAN, K.
10.1101/2025.07.01.662551 — immunology — Posted on 2025-07-04
1911 The systemic JIA synovial fluid environment supports development and prevalence of specific inflammatory T helper cell phenotypes
Schleifenbaum, S.; Swoboda, A.; Dirks, J.; Bracaglia, C.; Caiello, I.; Hinze, T.; Hardt, S.; Prencipe, G.; Tarantino, G.; Pardeo, M.; Fuehner, S.; Park, C.; Hinze, C.; Wittkowski, H.; Windschall, D.; Foell, D.; Morbach, H.; Kessel, C.
10.1101/2025.07.01.661738 — immunology — Posted on 2025-07-04
1912 Distinct systemic and gut IgA responses to bacteria of the human upper gastrointestinal tract
Vaz, F.; Lindeman, I.; Hoffmann, H. H.; Skagen, C.; Steffensen, A. K.; Bjornholt, J. V.; Tjonnfjord, G. E.; Lundin, K. E. A.; Sollid, L. M.; Iversen, R.
10.1101/2025.07.01.662496 — immunology — Posted on 2025-07-04
1914 Molecular Dynamics in the Ventral Tegmental Area during Chronic Pain-Induced Negative Affect
Diezel, C. C.; Majuta, L. A.; Bahramnejad, E.; Karlage, K. L.; Partin, J. L.; Barbour, S. M.; Peterson, I. L.; Flowers, M.; von Hippel, S. T.; Haveman, R.; Villarroel, E.; Villarroel, I.; Langlais, P. R.; Largent-Milnes, T. M.; Vanderah, T. W.; Riegel, A. C.
10.1101/2025.07.01.662604 — neuroscience — Posted on 2025-07-04
1915 Stool Dynamics and the Developing Gut Microbiome During Infancy
Al-Andoli, M.; Schoch, S.; Markovic, A.; Muhlematter, C.; Beaugrand, M.; Jenni, O.; Liamlahi, R.; Walser, J.-C.; Nielsen, D. S.; Kurth, S.
10.1101/2025.06.30.662361 — systems biology — Posted on 2025-07-04
1916 Understanding the kinetics of macrophage uptake and the metabolic fate of iron-carbohydrate complexes used for iron deficiency anemia treatment
Eitner, S.; Kissling, V. M.; Rippl, A.; Krupnik, L.; Buergi, J.; Gaechter, S.; Hast-Sribike, K.; Gogos, A.; Bottone, D.; Bossart, J.; Riudavets Puig, R.; Digigow, R.; Alston, A. E.; Fluehmann, B.; Wick, P.; Ayala-Nunez, V.
10.1101/2025.07.01.662524 — pharmacology and toxicology — Posted on 2025-07-04
1917 OmniCorr: An R-package for visualizing putative host-microbiota interactions using multi-omics data
Gupta, S.; Lai, W.; Kobel, C. M.; Aho, V. T. E.; Vera-Ponce de Leon, A.; La Rosa, S. L.; Sandve, S. R.; Pope, P. B.; Hvidsten, T. R.
10.1101/2025.07.01.662509 — bioinformatics — Posted on 2025-07-04
1919 NANOME: A Nextflow pipeline for haplotype-aware allele-specific consensus DNA methylation detection by nanopore long-read sequencing
Liu, Y.; Taha, H. B.; Zhang, Q.; Pan, Z.; Chatzipantsiou, C.; Wade, E.; Slocum, T.; Karuturi, L.; Zhao, Y.; Karmakar, S.; Li, S.
10.1101/2025.06.29.662079 — bioinformatics — Posted on 2025-07-04
1922 Evolution and comparative genomics of tick-associated endosymbionts: insights into metabolic pathways and historical biogeographic patterns
Echeverry-Perez, J. S.; Castelli, M.; Munoz-Leal, S.; Nava, S.; Sassera, D.; Sanchez-Vialas, A.; Olmeda, A. S.; Valcarcel, F.; Uribe, J. E.
10.1101/2025.07.01.660216 — evolutionary biology — Posted on 2025-07-04
1926 SpatioEv: Spatial evolution of protein and morphological features reveals development dynamics of cells and spatial neighbourhoods
Wu, S.; Amin, S.; Lee, C.; Richard, J.-B.; Merali, N.; Morrell, C.; Overend, L.; Gao, W.; Tucci, F.; Gordon-Weeks, A.; Framton, A.; Annels, N.; Culver, E.; Dustin, M.; Midwood, K.; Bashford-Rogers, R.
10.1101/2025.06.30.662328 — systems biology — Posted on 2025-07-04
1928 Phenology of Hyalomma marginatum in a site in southern French
STACHURSKI, F.; DUHAYON, M.; Appelgren, A.; BALANCA, G.; POLLET, T.; Vial, L.
10.1101/2025.06.30.662279 — pathology — Posted on 2025-07-04
1930 Spatial Proteomics of the Normal Breast Collagen Stroma: Links to BI-RADS Categories and Body Mass Index
Dunne, J. B.; Rujchanarong, D.; Park, Y.; Macdonald, J. K.; Hulahan, T. S.; Taylor, H. B.; Spruill, L.; Jensen-Smith, H.; Hollingsworth, M. A.; Sandusky, G. E.; Mehta, A. S.; Drake, R. R.; Ford, M. E.; Nakshatri, H.; Angel, P. M.
10.1101/2025.07.01.660922 — cancer biology — Posted on 2025-07-04
1931 Discovery of Light-Powered Organic Ion Transport by a Natural Protein
Shen, S.; Akita, S.; Wada, J.; Eguchi, M.; Tsukamoto, T.; Jung, K.-H.; Sudo, Y.; Kikukawa, T.
10.1101/2025.07.01.658226 — biophysics — Posted on 2025-07-04
1934 Uncertainty-Aware Discrete Diffusion Improves Protein Design
Mahbub, S.; Feinauer, C.; Ellington, C. N.; Song, L.; Xing, E. P.
10.1101/2025.06.30.662407 — bioinformatics — Posted on 2025-07-04
1935 Rapid and Reproducible Multimodal Biological Foundation Model Development with AIDO.ModelGenerator
Ellington, C. N.; Li, D.; Zou, S.; Cole, E.; Sun, N.; Addagudi, S.; Song, L.; Xing, E. P.
10.1101/2025.06.30.662437 — bioinformatics — Posted on 2025-07-04
1936 Targeted degradation of USP7 in solid cancer cells reveals disparate effects of deubiquitinase inhibition vs. acute protein depletion
Klink, N.; Urban, S.; Seier, J. A.; Adhikari, B.; Schwalm, M. P.; Müller, J.; Dorsch, M.; Kaschani, F.; Koch, J.; Führer, S.; Kaiser, M.; Schulze, N.; Knapp, S.; Wolf, E.; Paschen, A.; Grüner, B. M.; Gersch, M.
10.1101/2025.07.01.662351 — biochemistry — Posted on 2025-07-04
1940 Recombinase Polymerase Amplification of Forensic Short Tandem Repeat Loci
Skevin, S.; De Keyzer, L.; De Waele, L.; Tytgat, O.; Van Hoofstat, D.; Deforce, D.; Van Nieuwerburgh, F.
10.1101/2025.07.01.662531 — genomics — Posted on 2025-07-04
1943 Single-cell RNA sequencing in Hirschsprungs disease tissues reveals lack of neuronal differentiation in the aganglionic colon segment
Tarapcsak, S.; Huang, X.; Qiao, Y.; Farrell, A.; Mammen, L.; Lovichik, A.; Khanderao, G. D.; Musci, T.; Moos, P. J.; Firpo, M. A.; Rollins, M. D.; Marth, G. T.
10.1101/2025.07.01.662516 — genomics — Posted on 2025-07-04
1944 Multi-Tissue Profiling Reveals tissue-specific protein regulation and relationships Between Protein Quantitative Trait Loci (pQTLs) and Cardiometabolic Disease
Hartley, A. E.; Sukhavasi, K.; Hu, S.; Traylor, M.; Gonzalez-Ramirez, M.; Hanghoj, K. E.; Talukdar, H.; Ruusalepp, A.; Bjorkegren, E.; Bjorkegren, J.; Howson, J. M.; Jamshidi, Y.
10.1101/2025.06.30.662294 — genetics — Posted on 2025-07-04
1947 Comparative genomics and phylogenomics of the Mustelinae lineage (Mustelidae, Carnivora)
Totikov, A. A.; Tomarovsky, A. A.; Perelman, P. L.; Bulyonkova, T. M.; Serdyukova, N. A.; Yakupova, A. R.; Mohr, D.; Foerster, D. W.; Grau Jipoulou, J. H.; Beklemisheva, V. R.; Sidorov, M.; Miranda, I.; Farelo, L.; Abramov, A. V.; Krasheninnikova, K.; Mukhacheva, A. S.; Panov, V. V.; Balanovska, E.; Cherkasov, N.; Zub, K.; Scott, A. F.; Melo-Ferreira, J.; Okhlopkov, I. M.; Zhuk, A.; Koepfli, K.-P.; Kliver, S.
10.1101/2025.07.01.662473 — evolutionary biology — Posted on 2025-07-04
1952 Deep learning-based photo-identification for non-invasive monitoring of animal populations: Application to penguins and tortoises
Durr, N.; Rodriguez-Olmos, M.; Courtecuisse, J.; Gilbert, C.; Laidebeure, S.; Lecu, A.; Nord, A. L.; Pedaci, F.; Whittington, J. D.; Le Maho, Y.; Planas-Bielsa, V.
10.1101/2025.07.01.661353 — ecology — Posted on 2025-07-04
1955 Exploration of chemical probes and conformational flexibility of GID4 - the substrate receptor of human CTLH E3 ligase complex
Kotlarek, D.; Dudek, K.; Pokladek, Z.; Pastok, M. W.; Shishov, D.; Cottens, S.; Bista, M.; Krzywiecka, E.; Gorecka-Minakowska, K.; Jurczak, K.; Drmota, T.; Adamczyk, J.; Falinski, S. P.; Gajewska, D.; Klejnot, M.; Krol, A.; Cuprych-Belter, M.; Mames, I.; Mathieu, A.; Podkowka, A.; Przytulski, K.; Skowron, A. N.; Sypien, M.; Takagi, T.; Wanat, W.; Wierzbicki, I. H.; Wisniewski, J.; Szlachcic, A.; Wozniak, B.; Walczak, M. J.
10.1101/2025.07.01.662521 — molecular biology — Posted on 2025-07-04
1957 Single cell functional immunogenomics of the fallopian tube reveals a precursor immune surveillance network for ovarian cancer prevention
Wang, L.; Roskams-Hieter, B.; Hussain, N.; Nulsen, J.; Aggarwal, A.; Sallam, M.; Wang, L.; Rai, L.; Ahmed-Ebbiary, A.; Al-deka, A.; Takeda, T.; Artibani, M.; majd, H. S.; Yap, J.; Yau, C.; Zaarour, N.; Ahmed, A. A.
10.1101/2025.06.30.662408 — immunology — Posted on 2025-07-04
1958 Recognizing EEG responses to active TMS vs. sham stimulations in different TMS-EEG datasets: a machine learning approach
Keihani, A.; Donati, F. L.; Russo, S.; Parmigiani, S.; Solbiati, M.; Casali, A. G.; Fecchio, M.; Chaichian, O.; Rothwell, J.; Massimini, M.; Rocchi, L.; Rosanova, M.; Ferrarelli, F.
10.1101/2025.06.29.662189 — neuroscience — Posted on 2025-07-04
1959 TMC1 and TMC2 are cholesterol-dependent scramblases that regulate membrane homeostasis in auditory hair cells
Lee, H.; Park, Y. C.; Wen, H.; Smith, H. E.; Balaraman, J.; Cui, R.; Sotomayor, M.; Ballesteros, A.
10.1101/2025.07.03.663083 — neuroscience — Posted on 2025-07-04
1962 Targeted ablation and regeneration of enteric nervous system neurons in zebrafish
Shah, M. A.; Moran, K. K.; Rueckert, H.; Sharrock, A. V.; Ackerley, D. F.; Mumm, J. S.; Ganz, J.
10.1101/2025.07.01.660701 — neuroscience — Posted on 2025-07-04
1963 Low and high frequency signatures of impaired consciousness in temporal lobe seizures
Yadav, T.; Litvinov, B. P.; Culler, G. W.; Kumar, A.; Khalaf, A.; Song, Y.; Brinkmann, B. H.; Joseph, B.; Ahmad, Z.; Gunawardane, N.; Ramirez, V. C.; Quraishi, I. H.; START Clinical Trial Research Consortium, ; Jobst, B. C.; Worrell, G.; Blumenfeld, H.
10.1101/2025.07.01.662627 — neuroscience — Posted on 2025-07-04
1964 Adaptive changes of cholinergic projections to the nucleus accumbens bidirectionally mediate cocaine reinforcing effects
Aguiar, L. A.; Royon, L.; Bastos- Goncalves, R.; Carvalho, T. T.; Teixeira, E.; Faria, A. C.; Vasconcelos, N. A.; Pinto, L.; Fernandez, S. S.; Barik, J.; Coimbra, B.; Rodrigues, A. J.
10.1101/2025.06.30.662309 — neuroscience — Posted on 2025-07-04
1966 Ulk1(S555) inhibition alters nutrient stress response by prioritizing amino acid metabolism
Willoughby, O. S.; Nichenko, A. S.; Brisendine, M. H.; Amiri, N.; Henry, S. N.; Braxton, D. S.; Brown, J. R.; Specht, K. S.; Addington, A. K.; Zaitsev, A. V.; Burrows, S. T.; McMillan, R. P.; Zhang, H.; Tye, S. A.; Najt, C. P.; Craige, S. E.; Rhoads, T. W.; Warren, J. S.; Drake, J. C.
10.1101/2025.06.30.662412 — physiology — Posted on 2025-07-04
1968 Vascular transcriptional and metabolic changes precede progressive intra-renal microvascular rarefaction in autosomal dominant polycystic kidney disease
Yilmaz, G.; Singha, S. K.; Savaliya, B.; Abdelfattah, A.; Elsekaily, W.; Xu, X.; Zhang, Y.; Hanna, C.; Hogan, M. C.; Chade, A. R.; Eirin, A.; Irazabal, M. V.
10.1101/2025.06.30.662386 — physiology — Posted on 2025-07-04
1970 Acute cold exposure in humans shifts the circulating proteome to a cardioprotective and anti-aging profile
Plucinska, K.; Chen, Z.-Z.; Xiang, R.; Zaman, S.; Yan, L.; Hurson, C.; Peterson, C.; Fredrickson, K.; Farrell, L.; Walker, J.; Kars, M. E.; Tiwari, G.; Pourquie, O.; Itan, Y.; Carroll, T.; Chen, K. Y.; Cypess, A. M.; Gerszten, R. E.; Cohen, P.
10.1101/2025.06.30.662436 — physiology — Posted on 2025-07-04
1971 The Effects of Oral Contraceptives on Grip Strength and Neuromuscular Activation During Short-Term Immobilization and Rehabilitation of the Wrist/Hand
Stock, M. S.; Bauerlein, H. M.; Edwards, M. F.; Stambaugh, K. E.; Parsowith, E. J.; Carr, J. C.; Smith-Ryan, A. E.; Richardson, R. M.
10.1101/2025.07.01.662432 — physiology — Posted on 2025-07-04
1975 Coupling between acid-sensing ion channel 1a and the monocarboxylate transporter family shapes cellular pH response
Poulsen, M. H.; Ritter, N.; Maurya, S.; Xue, F.; Haider, S. S.; Usher, S. G.; Heusser, S. A.; Chua, H. C.; Fisker-Andersen, J.; Kickinger, S.; Schramek, D.; Wellendorph, P.; Lundby, A.; Pless, S. A.
10.1101/2025.06.30.651016 — biophysics — Posted on 2025-07-04
1976 Systematic DNA nicking reveals the structural logic of protein recognition
Yao, Y. M.; O'Hagan, M. P.; Onoon, K.; Givon, L.; Hamer-Rogotner, S.; Salinas, R.; Kessler, N.; Dym, O.; Pipatpolkai, T.; Schumacher, M. A.; Afek, A.
10.1101/2025.06.30.662289 — biophysics — Posted on 2025-07-04
1979 Structural and Functional Mechanisms Underlying Activation Gate Dynamics and IFM Motif Accessibility in Human Nav1.5
Biswas, R.; Lopez-Serrano, A. L.; Purohit, A.; Ramirez-Navarro, A.; Huang, H.-L.; Cheng, X.; Heissler, S. M.; Deschenes, I.; Chinthalapudi, K.
10.1101/2025.06.29.662239 — biophysics — Posted on 2025-07-04
1981 MarkerMatch: A Proximity-Based Probe-Matching Algorithm for Joint Analysis of Copy-Number Variants from Different Genotyping Arrays
Ivankovic, F.; Yu, D.; Shen, J.; Zhan, L.; Niarchou, M.; Kaylor, A.; Domenech, L.; Miller-Fleming, T. W.; Porras, L. M.; Giusti-Rodriguez, P.; Ophoff, R. A.; Scharf, J. M.; Mathews, C. A.
10.1101/2025.06.30.662249 — bioinformatics — Posted on 2025-07-04
1982 CENTRA: Knowledge-Based Gene Contexuality Graphs Reveal Functional Master Regulators by Centrality and Fractality
Hause, F.; Wedler, A.; Keil, R.; Schian, L.; Glass, M.; Guenther, W.; Sorokin, O.; Hoehenwarter, W.; Sinz, A.; Huettelmaier, S.
10.1101/2025.06.30.662180 — bioinformatics — Posted on 2025-07-04
1985 Unbiased whole genome comparison of Pan paniscus (bonobo) and Homo sapiens (human) through a novel sequence match-based approach
Rosler, C.; DuFriend, D.; Annor, E.; Njoroge, R.; Davis, E.; Anthem, Y. L.; Velasquez, C.; Ranahan, W. P.; Goelzer, M. H.; Wheat, S.; Goelzer, J. A.
10.1101/2025.06.30.659717 — bioinformatics — Posted on 2025-07-04
1988 The enduring advantages of the SLOW5 file format for raw nanopore sequencing data
Gamaarachchi, H.; Jenner, S.; Samarakoon, H.; Ferguson, J. M.; Deveson, I. W.
10.1101/2025.06.30.662478 — bioinformatics — Posted on 2025-07-04
1991 Cryopreservation of siRNA-treated cells is feasible
Sauer, M.; Segarra-Visent, X.; Breuer, L.; Tzirtziganis, V.; Ryaykenen, T.; Cooper, D. A.; Echeverria, D.; Kremer, A.; Haraszti, R. A.
10.1101/2025.07.01.662546 — bioengineering — Posted on 2025-07-04
1994 High-Quality PacBio Genome Assembly of Populus alba L. Villafranca
Sarfraz, I.; Zuccolo, A.; Celii, M.; Francini, A.; Wing, R. A.; Sebastiani, L.
10.1101/2025.06.30.661909 — genomics — Posted on 2025-07-04
1995 Investigations into genetic control of six spike traits with a focus on breeding for terminal heat stress tolerance in common wheat
Kumar, S.; Kumar, S.; Singh, V. P.; Sharma, H.; Rawale, K. S.; Bhatt, S. K.; Vairamani, R.; Gill, K. S.; Balyan, H. S.
10.1101/2025.06.30.662399 — genetics — Posted on 2025-07-04
1998 Bi-allelic mutations in KCTD11 cause a new form of autosomal recessive intermediate Charcot-Marie-Tooth disease
Gadacha, J.; Haidar, Z.; Roeckel-Trevisiol, N.; Pauset, A.; Castro, C.; Provost, C.; Hamze, Z.; Humbert, C.; Bertaux, K.; Lenfant, N.; Masingue, M.; de Becdelievre, A.; Konyukh, M.; Bonello, N.; Lia, A.-S.; Delmont, E.; Bertini, A.; Quartesan, I.; Facchini, S.; Cortese, A.; Reilly, M.; Houlden, H.; Pareyson, D.; Pisciotta, C.; Attarian, S.; Urtizberea, A.; Megarbane, A.; Jabbour, R.; Bernard-Marissal, N.; Delague, V.
10.1101/2025.06.30.661538 — genetics — Posted on 2025-07-04
1999 A reference panel for linkage disequilibrium and genotype imputation using whole-genome sequencing data from 2,680 participants across India
Li, Z.; Zhao, W.; Zhou, X.; Leung, Y. Y.; Schellenberg, G. D.; Wang, L.-S.; Dey, S.; Lee, J.; Smith, J. A.; Dey, A. B.; Kardia, S.
10.1101/2025.06.30.662450 — genetics — Posted on 2025-07-04
2001 Genomic approaches to build de novo elite breeding gene pools from locally-adapted landraces
Fall, S. T.; Kena, A.; Rice, B. R.; Kanfany, G.; Diatta, C.; Kane, N.; Fritz, A. K.; Morris, G. P.
10.1101/2025.06.30.662425 — genetics — Posted on 2025-07-04
2002 Rapid spread of knockdown resistance allele frequencies in a suburban population of Aedes albopictus
Baltzegar, J. F.; Butler, C.; Beeson, C.; Reed, E. M.; Ding, J. Y.; Reiskind, M. H.; Reiskind, M. O. B.
10.1101/2025.06.30.662396 — evolutionary biology — Posted on 2025-07-04
2009 Do heatwaves impact mosquitoes? Multi-level analyses across developmental stages in Aedes albopictus
Alfaro, C.; Lozada Chavez, A. N.; Khorramnejad, A.; Kropf, A.; Catapano, P. L.; Cappelli, A.; Damiani, C.; Favia, G.; Bonizzoni, M.
10.1101/2025.07.01.662530 — ecology — Posted on 2025-07-04
2013 T-bet expressing Tr1 cells driven by dietary signals dominate the small intestinal immune landscape
Ansaldo, E.; Yong, D.; Carrillo, N.; McFadden, T.; Abid, M.; Corral, D.; Farley, T.; Bouladoux, N.; Gribonika, I.; Belkaid, Y.
10.1101/2025.06.30.662190 — immunology — Posted on 2025-07-04
2014 Crosstalk Between ALPK1 and STING: A Synergistic Axis in Innate Immune Activation and Human Inflammatory Disease
Shi, C.-S.; Kozycki, C.; Huang, N.-N.; Hwang, I.-Y.; Hammoud, D. A.; Kastner, D. L.; Kehrl, J. H.
10.1101/2025.06.30.662363 — immunology — Posted on 2025-07-04
2015 Peptide-Specific CAR T cells Recognize WT1 Promiscuously Presented by Diverse HLA Class II Alleles
Wang, C.-H.; Zheng, E. Y. F.; Ochi, T.; Ohashi, Y.; Ihara, F.; Fukao, S.; Boukhaled, G. M.; Wang, B. X.; Han, D.-H.; Wei, X.; Burt, B. D.; Saso, K.; Matsunaga, Y.; Ly, D.; Kagoya, Y.; Butler, M. O.; Minden, M.; Hirano, N.
10.1101/2025.06.30.660492 — immunology — Posted on 2025-07-04
2016 WaveLimit: An optimal spike sorting inclusion boundary
Scherschligt, X.; Lee, W.-H.; Dallimore, C. A.; Schrader, E.; Liu, Z.; Rouse, A. G.
10.1101/2025.07.01.662629 — neuroscience — Posted on 2025-07-04
2017 Methodological determinants of signal quality in electrobulbogram recordings
Norden, F.; Zanettin, I.; Olsson, T.; Arshamian, A.; Lundqvist, M.; Darki, F.; Lundström, J. N.
10.1101/2025.07.01.662502 — neuroscience — Posted on 2025-07-04
2019 FREQ-NESS reveals age-related differences in frequency-resolved brain networks during auditory recognition and resting state
Malvaso, C.; Fernandez-Rubio, G.; Rosso, M.; Serra, E.; Rudi, V.; Vuust, P.; Kringelbach, M. L.; Testa, C.; Bonetti, L.
10.1101/2025.06.30.662094 — neuroscience — Posted on 2025-07-04
2021 Reading specific memories from human neurons before and after sleep
Ding, Y.; Dunn, S. L. S.; Sakon, J. J.; Duan, C.; Zhang, Y.; Berger, J. I.; Rhone, A. E.; Nourski, K. V.; Kawasaki, H.; Howard, M. A.; Roychowdhury, V. P.; Fried, I.
10.1101/2025.07.01.662486 — neuroscience — Posted on 2025-07-04
2022 Attention robustly dissociates objective performance and subjective visibility reports
Tian, K. J.; Maniscalco, B.; Epstein, M. L.; Shen, A.; Castaneda, O. G.; Kurosawa, T.; Motzer, J. A.; Olsson, E.; Russell, E. E.; Walsh, M. E.; Wang, J.; Zeb, T. B. A.; Brown, R.; Lamme, V. A.; Lau, H.; He, B. J.; Brascamp, J. W.; Block, N.; Chalmers, D.; Peters, M. A.; Denison, R. N.
10.1101/2025.07.03.661972 — neuroscience — Posted on 2025-07-04
2025 Denoising 7T Structural MRI with Conditional Generative Diffusion Models
Wang, Y.; Li, B.; Liang, Y.; Carlson, M.; DiGiacomo, P.; Taghavi, H. M.; Maclaren, J.; Bell, M.; Pham, N.; Decker, J. H.; lv, M.; Liang, T.; Wong, J.; Mormino, E.; Henderson, V. W.; Zaharchuk, G.; Rutt, B.; Shao, W.; Georgiadis, M.; Zeineh, M. M.
10.1101/2025.07.03.663033 — neuroscience — Posted on 2025-07-04
2026 Hypermyelination Improves Strength and Detection of Neuronal Activity in the CA1 Hippocampus and Facilitates Neuroprotection in FusOLcKO Mice
Wellman, S.; Guzman, K.; Suematsu, N.; Thai, T.; Tung, T.-H.; Padilla, C. G.; Sridhar, S.; Chen, K.; Cambi, F.; Kozai, T. D. Y.
10.1101/2025.06.30.662453 — neuroscience — Posted on 2025-07-04
2027 Perception of first and second pain during offset analgesia
Poehlmann, J.; von Lemm, B.; Luebke, L.; Adamczyk, W. M.; Luedtke, K.; Szikszay, T.
10.1101/2025.06.30.662291 — neuroscience — Posted on 2025-07-04
2028 Stress-induced plasminogen activator inhibitor-1 (PAI-1) as a blood biomarker and brain risk factor for PTSD
Mennesson, M.; Abdelkaoui, S.; Roullot-Lacarriere, V.; Tronel, S.; Cathala, A.; Lalanne, V.; Raux, P.-L.; Makrini, L.; Valjent, E.; Duffaud, A.; Claverie, D.; Vallee, M.; Desmedt, A.; Trousselard, M.; Revest, J.-M.
10.1101/2025.07.02.661922 — neuroscience — Posted on 2025-07-04
2029 Complementary Structural and Chemical Biology Methods Reveal the Basis for Selective Radioligand Binding to α-Synuclein in MSA Tissue
Sanchez, J. C.; Perez, R. M.; Guarino, D. S.; Dhavala, D.; Baumgardt, J. K.; Shaffer, K. D.; Kotzbauer, P.; Mach, R. H.; Petersson, E. J.; Wright, E. R.
10.1101/2025.06.30.662461 — neuroscience — Posted on 2025-07-04
2031 The chloride cotransporter NKCC1 regulates self-renewal of hippocampal neural stem cells via the transcription factor Sox11
Blank, A.; Adhikarla, S.; Broesske, J.; Kaiser, L.; Rippe, M.; Haase, M.; Groth, M.; Stein, G.; Andrae, T.; Mesterheide, J.; Fleischer, A.-L.; Flossmann, T.; Schaeffner, I.; Sock, E.; Kirmse, K.; Huebner, C. A.; Holthoff, K.; Schmeer, C.; Lie, D. C.; Keiner, S.
10.1101/2025.07.01.662334 — neuroscience — Posted on 2025-07-04
2039 Functional characterization of Ixodes neuropeptide receptors
Knox, C. A.; Kyle, L. L.; Szczesniak, L. M.; Reks, S. E.; Wojcikiewicz, R. J.; Knox, B. E.
10.1101/2025.06.30.662206 — neuroscience — Posted on 2025-07-04
2041 Human induced pluripotent stem cell-derived microglia with a CX3CR1-V249I genetic variant exhibit dysfunctional phenotypes and modulate neuronal growth and function
Tutrow, K. D.; Harkin, J.; Varghese, L. D.; Hernandez, M.; Huang, K.-C.; Fang, Y.; Wilcox, P.; Bedford, L. M.; Lin, T.-Y.; Zhang, C.; Gomes, C.; Puntambekar, S. S.; Bissel, S. J.; Lamb, B. T.; Meyer, J. S.
10.1101/2025.07.01.662163 — neuroscience — Posted on 2025-07-04
2042 Functionalization of lipid nanoemulsions with humanized antibodies using plug-and-play cholesterol anchor for targeting cancer cells
Boide-Trujillo, V. J.; Mittelheisser, V.; Liu, F.; Lefebvre, O.; Andreiuk, B.; Anton, N.; Goetz, J. G.; Klymchenko, A. S.
10.1101/2025.06.29.662210 — pharmacology and toxicology — Posted on 2025-07-04
2043 N-Alkyl Sulfamates as a New Class of nsP2 Cysteine Protease Inhibitors with Broad Spectrum Antialphaviral Activity
Ghosal, A.; Sears, J. D.; Hossain, M. A.; Tse, E.; Howell, S.; Burdick, J. E.; Morales, N. L.; Martinez, S. A.; Law, I.; Streblow, Z. J.; Streblow, D. N.; Counago, R. M.; Moorman, N. J.; Heise, M. T.; Willson, T. M.
10.1101/2025.06.30.662352 — pharmacology and toxicology — Posted on 2025-07-04
2046 Accurate Protein-Protein Interactions Modeling through Physics-informed Geometric Invariant Learning
Rao, J.; Liu, D.; Zhou, X.; Yuan, Q.; Wei, W.; Lu, W.; Zhang, J.; Rong, Y.; Yang, Y.; Zheng, S.
10.1101/2025.07.01.662544 — bioinformatics — Posted on 2025-07-04
2048 Rational design of oxidation-resistant antibodies through local electrostatic modulation
Lenka, S.; Mehta, S.; Stephens, N.; Seeger, F.; Liang, W.-C.; Watkins, A.; Zarzar, J.; Jafari, N.; Puno, R.; Azumaya, C.; Kelly, R.; Wu, S.; Chiu, C.; Hazen, M.; Wu, Y.; Irudayanathan, F. J.; Alavattam, S.; Kelley, B.; Izadi, S.
10.1101/2025.06.29.662139 — biochemistry — Posted on 2025-07-04
2050 Alizarin red perturbs skeletal patterning and biomineralization via Catalase inhibition
Descoteaux, A. E.; Radulovic, M.; Ghogale, M.; Chandragiri, S.; Shrestha, B. D.; Abayawardena, D.; Wikramanayake, A.; Prakash, V. N.; Bradham, C. A.
10.1101/2025.07.03.663060 — developmental biology — Posted on 2025-07-04
2055 CaMKII monomers are sufficient for GluN2B binding, co-condensation, and synaptic potentiation
Brown, C. N.; Barker, C. M.; Miller, C. N.; Aoto, J.; Coultrap, S. J.; Bayer, K. U.
10.1101/2025.07.04.663188 — neuroscience — Posted on 2025-07-04
2056 AAV-mediated gene therapy for SLC13A5 citrate transporter disorder rescues epileptic and metabolic phenotypes
Bailey, L. E.; Schackmuth, M. K.; Adams, R. M.; Garza, I. T.; Knight, K.; Holmes, S. K.; Eller, M. M.; Lee, M.; Bailey, R. M.
10.1101/2025.07.03.663044 — neuroscience — Posted on 2025-07-04
2058 The difficulty in numerical computation impacts motor decisions in a Stop Signal task
Marc, I. B.; Giuffrida, V.; Segreti, M.; Paul, A.; Fagioli, S.; Pani, P.; Ferraina, S.; Brunamonti, E.
10.1101/2025.07.01.662562 — neuroscience — Posted on 2025-07-04
2061 Multiplexed BOLD oscillations reveal the interplay of normalization and attention
Rafeh, R. W.; Ngo, G. N.; Muller, L. E.; Khan, A. R.; Menon, R. S.; Mur, M.; Schmitz, T. W.
10.1101/2025.07.01.662576 — neuroscience — Posted on 2025-07-04
2063 A human pluripotent stem cell tri-culture platform to elucidate microglial regulation of retinal ganglion cells in neuroinflammation
Harkin, J.; Gomes, C.; Tutrow, K. D.; Afify, R.; Patil, S. V.; Pena, K. H.; Baker, A.; Lavekar, S. S.; Huang, K.-C.; Meyer, J. S.
10.1101/2025.07.01.662573 — neuroscience — Posted on 2025-07-04
2066 An Early Olfactory Transcriptomic Signature of Tauopathy: Gbp2b Emerges as a Candidate Biomarker of Tau-Driven Neuroinflammation
Dourte, M.; Bouloki, A.; Dieu, M.; Magomadov, M.; Paitre, E.; Suelves, N.; Renard, P.; Kienlen-Campard, P.
10.1101/2025.07.01.662324 — neuroscience — Posted on 2025-07-04
2067 XBP1s as a Therapeutic Target to Preserve Retinal Function During Aging and Neurodegeneration
Medina, L. E.; Barria, J.; Chacon, M.; Orellana, M.; Ponce, D.; Neira, D.; Miqueles, F.; Duran-Aniotz, C.; Araya-Arriagada, J.; Cerda, B.; Hetz, C.; Rojas, C.; Palacios, A. G.
10.1101/2025.07.03.662890 — neuroscience — Posted on 2025-07-04
2068 Polarity-dependent modulation of sleep oscillations and cortical excitability in aging
Dikici, B.; Malinowski, R.; Kordass, J.-B.; Obermayer, K.; Ladenbauer, J.; Floeel, A.
10.1101/2025.07.03.662520 — neuroscience — Posted on 2025-07-04
2070 In vivo selection and glymphatic delivery of AAV5 capsids engineered to target human glial progenitor cells
Cona, A.; Newbold, E.; Kesmen, D.; Snape, R.; Danner, J.; White, N.; Borden, W.; Iseson, A.; Schanz, S. J.; Chandler-Militello, D.; Li, X.; Cano, J. C.; Mariani, J. N.; Nedergaard, M.; Benraiss, A.; Goldman, S. A.
10.1101/2025.07.03.662612 — neuroscience — Posted on 2025-07-04
2071 Predicting therapeutic windows for synaptic intervention in ALS
Strohmer, B.; Montanana-Rosell, R.; Mora, S.; Ausborn, J.; Allodi, I.
10.1101/2025.06.30.662290 — neuroscience — Posted on 2025-07-04
2074 Age-dependent remodeling of the sciatic proteome in 5xFAD mice can be attenuated by exercise or donepezil treatment to maintain neuromuscular function
Brisendine, M. H.; Nieves-Esparcia, D. Q.; Willoughby, O. S.; Brown, J. R.; Braxton, D. S.; Henry, S. N.; McCoin, C.; Thyfault, J.; Morris, J. K.; Poelzing, S.; Grange, R. W.; Najt, C. P.; Drake, J. C.
10.1101/2025.07.01.662603 — neuroscience — Posted on 2025-07-04
2078 Single-Domain Antibody-Based Autophagosome-Targeting Chimera for Tau Clearance and Motor Function Restoration in Tauopathies
Sigurdsson, E.; Jiang, Y.; Tetlow, A. M.; Lin, Y.; Ji, C.; Laborc, K. F.; Mar, A. C.; Pan, R.; Kong, X.-P.; Congdon, E. E.
10.1101/2025.06.30.662446 — neuroscience — Posted on 2025-07-04
2082 Internal phase separation in synthetic DNA condensates
Tanase, D. A.; Osmanovic, D.; Rubio-Sanchez, R. M.; Malouf, L.; Franco, E.; Di Michele, L.
10.1101/2025.03.19.644034 — biophysics — Posted on 2025-07-04
2086 Lesions in the cerebellum impact cross-modal temporal predictions
Criscuolo, A.; Knolle, F.; Schwartze, M.; Schröger, E.; Ivry, R.; Kotz, S. A.
10.1101/2025.07.04.663130 — neuroscience — Posted on 2025-07-04
2087 Obesogenic diet impairs memory consolidation via the hippocampal endocannabinoid system
Ducourneau, E. G.; Janthakhin, Y.; Oliveira da Cruz, J. F.; Artinian, J.; Alfos, S.; Helbling, J.-C.; Matias, I.; Bakoyiannis, I.; N'Diaye, M.; Bosch-Bouju, C.; Potier, M.; Bellocchio, L.; Busquets-Garcia, A.; Trifilieff, P.; Marsicano, G.; Ferreira, G.
10.1101/2025.07.04.663181 — neuroscience — Posted on 2025-07-04
2092 MagPiezo: a Magnetogenetic Platform for Remote Activation of Endogenous Piezo1 Channels in Endothelial Cells
Del Sol-Fernandez, S.; De Simone, M.; Fernandez-Afonso, Y.; Garcia-Gonzalez, D.; Martinez-Vicente, P.; van Zanten, T. S.; Fratila, R. M.; Moros, M.
10.1101/2025.06.30.661957 — bioengineering — Posted on 2025-07-04
2093 Antimicrobial Loaded Graft-Copolymer Nanoparticles for Treatment of Pseudomonas aeruginosa Infections
Soler, Y. V.; Xu, W.; Lima, M. R. N.; McDonald, J.; Jagpal, S. K.; Kirn, T. J.; Hussain, S.; Devore, D. I.; Roth, C. M.
10.1101/2025.07.03.663093 — bioengineering — Posted on 2025-07-04
2095 Altered cognitive processes shape tactile perception in autism.
Semelidou, O.; Tortochot-Megne Fotso, M.; Winderickx, A.; Frick, A.
10.1101/2025.06.25.661477 — neuroscience — Posted on 2025-07-04
2096 Using a Bacterial Protein to Selectively Target Bacterial Biofilms: Treatment of S. epidermidis Biofilms with Targeted Photothermal Gold Nanoparticles
Shaikh, T.; Amarasekara, D. L.; Somarathne, R. P.; Hulugalla, K.; Hejny, M. A.; McCaffrey, E. R.; Werfel, T.; Fitzkee, N. C.
10.1101/2024.09.03.610983 — biophysics — Posted on 2025-07-04
2098 Research on crop phenotype prediction using SNP context and whole-genome feature embedding
Huan, L.; peng, C. Y.; Zhen, C.; Ting, W.; Chao, W.; bo, B. W.; Juan, L.; Mo, W.; Li, C.; ming, W. J.
10.1101/2025.04.08.647762 — genetics — Posted on 2025-07-04
2099 Functional characterization of specialized immune cells in a cnidarian reveals an ancestral antiviral program
Kozlovski, I.; Sharoni, T.; Levy, S.; Jaimes-Becerra, A.; Talice, S.; Kwak, H.-J.; Aleshkina, D.; Aharoni, R.; Grau-Bove, X.; Karmi, O.; Rosental, B.; Sebe-Pedros, A.; Moran, Y.
10.1101/2025.01.24.634691 — evolutionary biology — Posted on 2025-07-04
2100 Evolution of hunt, kill, devour in a Vibrio ecospecies
Svensson, S. L.; Wen, H.; Jia, Z.; Xie, Z.; Xu, W.; Fu, H.; Yang, C.; Chao, Y.; Falush, D.
10.1101/2025.06.27.661923 — microbiology — Posted on 2025-07-04
2101 A single cell multi-omic analysis identifies molecular and gene-regulatory mechanisms dysregulated in the developing Down syndrome neocortex
Vuong, C. K.; Weber, A.; Seong, P.; Matoba, N. K.; Shafie, B.; Salinda, A.; Zhang, P.; Chen, Y.-J.; Nichterwitz, S.; Younesi, S.; Qi, L.; Gandal, M. J.; Geschwind, D. H.; Stein, J. L.; de la Torre-Ubieta, L.
10.1101/2025.06.30.662136 — genomics — Posted on 2025-07-04
2106 Sex effects on gene expression across the human cerebral cortex at single cell resolution
DeCasien, A. R.; Auluck, P.; Liu, S.; Marenco, S. R.; Cookson, M. R.; Raznahan, A.
10.1101/2025.06.30.661781 — neuroscience — Posted on 2025-07-04
2107 One-step induction of human GABAergic neurons promotes presynaptic development & synapse maturation
van Voorst, T. W.; van boven, M. A.; Marinus, K. I.; Colon-Mercado, J. M.; Schretzmeir, J.; Haag, C.; Toonen, R. F.; Koopmans, F.; Ward, M.; Smit, A. B.; van Kesteren, R. E.; Verhage, M.; Cornelisse, L. N.
10.1101/2025.06.30.662293 — neuroscience — Posted on 2025-07-04
2108 CB1 receptor inhibition in fragile X syndrome mice impacts alternative splicing alterations in hippocampal synaptoneurosomal transcriptome
de los Reyes-Ramirez, L.; Ciaran-Alfano, L.; Reixachs-Sole, M.; Bergada-Martinez, A.; Galera-Lopez, L.; Martinez-Torres, S.; Navarro-Romero, A.; Maldonado, R.; Eyras, E.; Ozaita, A.
10.1101/2025.07.01.662539 — neuroscience — Posted on 2025-07-04
2109 Subtype-Specific Roles of Nigrostriatal Dopaminergic Neurons in Motor and Associative Learning
Habib, A.; Riccobono, G. T.; Tian, L.; Basu, D.; Sun, L.; Chang, L.; Martinez-Smith, V.; Wang, L.; Le, W.; Cai, H.
10.1101/2025.07.03.663035 — neuroscience — Posted on 2025-07-04
2110 Robust Production of Parvalbumin Cortical Interneurons and Fast-Spiking Neurons from Human Medial Ganglionic Eminence Organoids
Varela, M. C.; Walker, M. P.; Bok, J.; Crespo, E. L.; Thenstedt, T.; Goldstein, L.; Tidball, A. M.; Li, J. Z.; Yuan, Y.; Isom, L.; Fu, J.; Uhler, M.; Parent, J. M.
10.1101/2025.07.01.662594 — neuroscience — Posted on 2025-07-04
2111 Molecular and cellular processes disrupted in the early postnatal Down syndrome prefrontal cortex
Risgaard, R. D.; Arachchilage, K. H.; Knaack, S. A.; Hosseini, M.; Chen, R. J.; Kumarage, P.; Schmidt, D. K.; Huang, X.; Sheng, J.; Wang, C. J.; Giusti, E.; Liu, S.; Zhang, S.-C.; Wang, D.; Bhattacharyya, A.; Sousa, A. M. M.
10.1101/2025.06.30.662385 — neuroscience — Posted on 2025-07-04
2112 Cell Type-Specific Changes in Dendritic Spines Across Adolescence Within Mouse Medial Prefrontal Cortex
Klappenbach, C.; Wang, Q.; Lenkersdorfer, K.; Buursma, J.; Acuna, J.; Chu, J.; Chen, W.; Richards, K.; Touretsky, K.; Herrera, X.; Delevich, K. M.
10.1101/2025.07.03.663087 — neuroscience — Posted on 2025-07-04
2114 Continental-scale integration of soil metagenomes and metabolomes reveals ubiquitous microbial capacity for recalcitrant carbon decomposition.
Song, Y. C.; Shi, C.; Stratton, K. G.; Stohel, I.; Freire-Zapata, V.; Tfaily, M. M.; Eloe-Fadrosh, E. L.; Graham, E. B.
10.1101/2025.07.03.663048 — microbiology — Posted on 2025-07-03
2118 PROFET Predicts Continuous Gene Expression Dynamics from scRNA-seq Data to Elucidate Heterogeneity of Cancer Treatment Responses
Cheng, Y.-C.; Gu, H.; McDonald, T. O.; Wu, W.; Tripathi, S.; Guarducci, C.; Russo, D.; Abravanel, D. L.; Bailey, M.; Wang, Y.; Zhang, Y.; Pantazis, Y.; Levine, H.; Jeselsohn, R.; Katsoulakis, M. A.; Michor, F.
10.1101/2025.06.27.662030 — bioinformatics — Posted on 2025-07-03
2121 Developmental PBDE exposure impairs histamine release dynamics in adult male and female mice via disrupted granule maturation and calcium mobilization
Franges, J.; Malinowski, L.; De Alwis, C.; Doolittle, T.; Dixon, H.; Tang, Y.; Watson, H.; Peace, J.; Jima, D.; Sombers, L.; McCarthy, G.; Patisaul, H.; Stapleton, H.; Duque-Wilckens, N.
10.1101/2025.06.28.661534 — pharmacology and toxicology — Posted on 2025-07-03
2125 Human protein interactome structure prediction at scale with Boltz-2
Ille, A. M.; Markosian, C.; Burley, S. K.; Pasqualini, R.; Arap, W.
10.1101/2025.07.03.663068 — bioinformatics — Posted on 2025-07-03
2127 Mapping the Fascicular Morphology and Organization of the Human Sciatic Nerve via High-Resolution MicroCT Imaging
Zhang, J.; Lam, V. H.; Nuzov, N. B.; Brunsman, B. A. S.; Pascol, T.; Onabiyi, A.; Prince, R.; Kalpatthi, H.; Gustafson, K.; Triolo, R.; Pelot, N. A.; Crofton, A.; Shoffstall, A. J.
10.1101/2025.06.28.662133 — bioengineering — Posted on 2025-07-03
2128 An Enhancement of Extrachromosomal Circular DNA Enrichment and Amplification to Address the Extreme Low Overlap Between Replicates
Burnham, C. M.; Kurilung, A.; Wanchai, V.; Regenberg, B.; Delgado-Calle, J.; Basnakian, A. G.; Nookaew, I.
10.1101/2025.06.28.662146 — genomics — Posted on 2025-07-03
2129 Microbial N2O reduction in sulfidic waters:Implications for Proterozoic oceans
Buessecker, S.; Klos, A. S.; Quan, M. E.; Finch, A. H.; Sobol, M. S.; Evans, G. N.; Anbar, A. D.; Kacar, B.; Dekas, A. E.
10.1101/2025.06.28.662143 — ecology — Posted on 2025-07-03
2130 Drone-Based Monitoring of Reproductive Potential in a Foundational Shrub Species
Wickersham, R.; Cattau, M. E.; Forbey, J. S.; Marie, V.; Zaiats, A.; Delparte, D.; Caughlin, T. T.
10.1101/2025.06.27.662010 — ecology — Posted on 2025-07-03
2133 Intra-host genomic variation of Haemophilus influenzae isolates from asymptomatic nasopharyngeal carriers involves genes encoding proteins with diverse inferred functions
Olsen, R.; Long, S. W.; Vedaraju, Y.; Tomasdottir, S.; Erlendsdottir, H.; Haraldsson, A.; Kristinsson, K.; Musser, J. M.; Haraldsson, G.
10.1101/2025.07.03.663008 — microbiology — Posted on 2025-07-03
2135 Monitoring Candida albicans Biofilm Formation by Impedance Using Passive RFID
Makarovaite, V.; A.J.R. Hillier, A. J. R.; Holder, S. J.; Gourlay, C.; Batchelor, J. C.
10.1101/2025.07.03.662933 — microbiology — Posted on 2025-07-03
2137 Modulation of Transferrin receptor by HIV-2
Al-Muffti, A. S.; Kiarie, I. W.; Tozser, J.; Mahdi, M.
10.1101/2025.07.03.663036 — microbiology — Posted on 2025-07-03
2138 Enterococcus faecalis persists and replicates intracellularly within neutrophils
Stocks, C. J.; Goncalves da Silva, R. A.; Antypas, H.; Jeyabalan, N.; Wong, S. L.; Kline, K. A.
10.1101/2025.07.03.662968 — immunology — Posted on 2025-07-03
2140 Orthorexia is associated with a paradoxical appetitive gastric response to unhealthy foods
Gumussoy, M.; Anisimova, E.; Lee, S.; Velummylum, A.; Cox, S.; Bagley, E.; Nord, C. L.; Dalmaijer, E. S.
10.1101/2025.06.27.661259 — physiology — Posted on 2025-07-03
2141 Optimizing automated sleep stage scoring of 5-second mini-epochs: a transfer learning study
Follin, L. F.; Christensen, J. A. E.; Vevelstad, J.; Juvodden, H. T.; Viste, R.; Hansen, B. H.; Perslev, M.; Kaufmann, T.; Zahid, A. N.; Knudsen-Heier, S.
10.1101/2025.06.28.661238 — bioengineering — Posted on 2025-07-03
2143 A 4D Bio-Kirigami Strategy for Engineering Complex Tissue Curvatures
Gasvoda, K. L.; Ding, A.; Sterenberg, A.; Jeon, O.; Alsberg, E. L.
10.1101/2025.06.28.662122 — bioengineering — Posted on 2025-07-03
2146 Gempipe: a tool for drafting, curating and analyzing pan and multi-strain genome-scale metabolic models.
Lazzari, G.; Felis, G. E.; salvetti, E.; Calgaro, M.; Di Cesare, F.; Teusink, B.; Vitulo, N.
10.1101/2025.07.03.662949 — microbiology — Posted on 2025-07-03
2147 Microbiota discovered in scorpion venom
Murdoch, B.; Kleinschmit, A. J.; Santibanez-Lopez, C. E.; Graham, M. R.
10.1101/2025.07.03.662918 — microbiology — Posted on 2025-07-03
2155 AxoMetric: A Rapid and Unbiased Tool for Automated Quantification of Axon Regeneration in Tissue Sections
Finneran, M. C.; Rhamani, T.; Salioski, I. V.; Schmitd, L. B.; Passino, R.; Johnson, C. N.; Giger, R.
10.1101/2025.07.02.662816 — neuroscience — Posted on 2025-07-03
2161 Timing, movement, and reward contributions to prefrontal and striatal ramping activity
Bova, A.; Weber, M. A.; Spicer, M. M.; Khandelwal, V.; Volkman, R. A.; McMurrin, M.; Kryca, J.; Sivakumar, K.; Kirkpatrick, B.; Zhang, Q.; Narayanan, N.
10.1101/2025.07.02.662841 — neuroscience — Posted on 2025-07-03
2162 Prior Information Shapes Perceptual Evidence Accumulation Dynamics Differentially in Psychosis
Franzen, L.; Eickhoff, S.; Andreou, C.; Delis, I.; Erb, J.; Kreitewolf, J.; Lencer, R.; Lange, C.; Schmitt, L.-M.; Schewe, H.; Kloosterman, N.; Tune, S.; Borgwardt, S.; Obleser, J.
10.1101/2025.07.03.662942 — neuroscience — Posted on 2025-07-03
2163 REMI: Reconstructing Episodic Memory During Intrinsic Path Planning
Wang, Z.; Morris, G.; Derdikman, D.; Chaudhari, P.; Balasubramanian, V.
10.1101/2025.07.02.662824 — neuroscience — Posted on 2025-07-03
2166 Characterization of mice with cell type-specific Gnal loss of function provides insights on GNAL-linked dystonia
LONGUEVILLE, S.; YUAN, R.; NAON, C.; VALJENT, E.; PELOSI, A.; ROZE, E.; MARIANI, L.-L.; GIRAULT, J.-A.; HERVE, D.
10.1101/2025.07.02.662743 — neuroscience — Posted on 2025-07-03
2167 MoMo - Combining Neuron Morphology and Connectivity forInteractive Motif Analysis in Connectomes
Shewarega, M. F.; Troidl, J.; Rodriguez, O. A.; Dindoost, M.; Harth, P.; Haberkern, H.; Stegmaier, J.; Bader, D.; Pfister, H.
10.1101/2025.07.02.662847 — neuroscience — Posted on 2025-07-03
2168 Neural trajectories improve motor precision
Lee, W.-H.; Scherschligt, X.; Nishimoto, M.; Rouse, A. G.
10.1101/2025.07.01.662682 — neuroscience — Posted on 2025-07-03
2172 Connectome analysis of a cerebellum-like circuit for sensory prediction
Perks, K. E.; Petkova, M. D.; Muller, S. Z.; Genecin, M.; Ghatare, A.; Schalek, R.; Wu, Y.; Januszewski, M.; Jain, V.; Lichtman, J. W.; Abbott, L.; Sawtell, N. B.
10.1101/2025.07.03.662989 — neuroscience — Posted on 2025-07-03
2179 Parkinsons disease microglia induce endogenous alpha-Synuclein pathology in patient-specific midbrain organoids.
Zuccoli, E.; Kurniawan, H.; Rosety, I.; Zagare, A.; Sabate-Soler, S.; Zimmermann, A.-S.; Schwamborn, J. C.
10.1101/2025.07.01.662685 — neuroscience — Posted on 2025-07-03
2181 Comparison of AAV9-driven motor neuron transduction following different CNS-directed delivery methods in mice
Mole, A. J.; Sander, C. F.; Parmar, A. R.; Williams, A. J.; Azzouz, M.; Hautbergue, G. M.; Shaw, P. J.; Ferraiuolo, L.; Mead, R. J.
10.1101/2025.07.01.662642 — neuroscience — Posted on 2025-07-03
2184 Accurate and Interpretable Prediction of Antidepressant Treatment Response from Receptor-informed Neuroimaging
Tolle, H. M.; Luppi, A. I.; Lawn, T.; Roseman, L.; Nutt, D.; Carhart-Harris, R. L.; Mediano, P. A. M.
10.1101/2025.07.02.662710 — neuroscience — Posted on 2025-07-03
2188 Cortex-Wide, Cellular-Resolution Volumetric Imaging with a Modular Two-Photon Imaging Platform
Li, B.; Hu, J.; Zhu, Y.; Liu, S.; Li, C.; Zhang, M.; Gu, X.; Wu, J.; Xu, F.; Mao, Y.
10.1101/2025.07.03.662899 — neuroscience — Posted on 2025-07-03
2189 White adipose tissue undergoes pathological dysfunction in the TDP-43A315T mouse model of amyotrophic lateral sclerosis (ALS)
Benito-Casado, C.; Duran-Mateos, E.; Ferrer-Donato, A.; Barroso Garcia, G.; Dominguez-Rubio, R.; Povedano, M.; Fernandez-Martos, C. M.
10.1101/2025.07.03.662925 — neuroscience — Posted on 2025-07-03
2195 A technical semi-field methodology to measure the effect of nutrition on honeybee brood rearing
Goncalves, R. F. d. S.; De Sousa, R. T.; Stabler, D.; Pinto, D. M. S.; Wright, G. A.; Shafir, S.
10.1101/2025.07.01.662504 — animal behavior and cognition — Posted on 2025-07-03
2197 Better Safe Than Sorry: Leg Amputations as a Prophylactic Wound Care Behaviour in Carpenter Ants
Fujimoto, S.; Oviedo, J. J. L.; Seibel, F.; Puille, L.; Hausmann, R.; Corcoran, E.; Schmitt, T.; Frank, E. T.
10.1101/2025.06.29.662171 — animal behavior and cognition — Posted on 2025-07-03
2199 Linking host personality and parasitic infection: a meta-analysis
Piscitelli, A. P.; Messina, S.; Wauters, L. A.; Santicchia, F.; Matthysen, E.; Leirs, H.; Vanden Broecke, B.
10.1101/2025.06.30.662423 — animal behavior and cognition — Posted on 2025-07-03
2203 Seasonality, land use, and diversity shape microbiome-pathogen interactions in wild populations of Arabidopsis thaliana
Henry, L. P.; Rat, A.; Laderman, E.; Lion, R.; Mayjonade, B.; TEAM PATHOCOM, ; Roux, F.; Weigel, D.; Bergelson, J.
10.1101/2025.06.29.662221 — ecology — Posted on 2025-07-03
2205 Disruption of hemocyte differentiation and distribution in Drosophila Ptr23c mutants
Parada, C.; Silvera, M. C.; de los Campos, T.; Cantera, R.; Bolatto, C.; Prieto, D.
10.1101/2025.07.03.662979 — developmental biology — Posted on 2025-07-03
2206 Autism-associated oxysterol regulates GABAergic neurogenesis and subtype fates
Cruz-Santos, M.; Kidd, E.; Li, Z.; De la Fuente, D. C.; Davies, S.; Vinh, N.-N.; Fjodorova, M.; Li, M.
10.1101/2025.07.01.662540 — developmental biology — Posted on 2025-07-03
2208 Neural Synchrony in Parent-Child Dyads: Profiles Associated with Interparental Conflict and Internalizing Symptoms
Alvarado, C.; Panlilio, C. C.; Perez-Edgar, K.; Thompsom, K. I.; Schaedig, D.; Melhem, N.; Perlman, S. B.
10.1101/2025.07.02.662817 — developmental biology — Posted on 2025-07-03
2209 Integration of auxin and cytokinin signalling in Arabidopsis root meristem maintenance through the secreted peptide CLE40
Thiele, M.; Wink, R.; Stahl, Y.; Narasimhan, M.; Augustin, S.; Schlegel, J.; Breiden, M.; Soltanzadah, S.; Pallakies, H.; Pinto, K. G.; Schön, J.; Zurbriggen, M. D.; Simon, R.
10.1101/2025.07.01.662337 — developmental biology — Posted on 2025-07-03
2210 CD4+ T cells promote fibrosis during metabolic dysfunction-associated steatohepatitis
Valenzuela-Perez, L.; Kim Lee, H. S.; Bayer, R. L.; Mishra, S. K.; Washington, A. M.; Guo, Q.; Herman, A.; Graham, R. P.; Sidahmed, M. M.; Ssali, E.; Hassan, A. A.; Dinc, E. J.; Pavelko, K. D.; Gores, G. J.; Starlinger, P.; Revelo, X. S.; Ibrahim, S. H.; Kostallari, E.; Bamidele, A. O.; Hirsova, P.
10.1101/2025.06.27.660220 — immunology — Posted on 2025-07-03
2211 Morphogenesis-on-chip: A minimal in vitro assay for cell intercalation highlights the importance of interfacial tension and migratory forces
Ruppel, A.; Misiak, V.; Arzash, S.; Herrador, D. S.; Cappello, G.; Boudou, T.; Manning, L.; Fagotto, F.; Balland, M.
10.1101/2025.06.30.662274 — biophysics — Posted on 2025-07-03
2212 Sealable capped nanovials for high-throughput screening of cell growth and function
Mellody, M. P.; Nakagawa, Y.; Arnheim, A.; Shang, L.; Soo, C.; Tsubamoto, N.; Taylor, S.; Shastry, S.; Luk, W.; Morales, I.; James, R.; Di Carlo, D.
10.1101/2025.06.29.662236 — bioengineering — Posted on 2025-07-03
2214 Integrating microfluidic automation into thermoplastic devices for analysis of small volumes of blood
Revzin, A.; Hernandez, J. A.; Suarez, A. G.; Stybayeva, G.; Robledo, G. C.; Garcia-Cordero, J.
10.1101/2025.06.28.662160 — bioengineering — Posted on 2025-07-03
2215 A Membrane-Disruptive Action of VBIT-4 Challenges Its Role as a Widely Used VDAC Oligomerization Inhibitor
Ravishankar, V.; Borges-Araujo, L.; Lafargue, E.; Byrne, D.; Buzhinsky, N.; Wolfe, M.; Bautista, N.; Beyene, B.; Larimi, M.; Duneau, J.-P.; Sturgis, J.; Rajendran, M.; Bezrukov, S.; Casuso, I.; Rostovtseva, T. K.; Bergdoll, L.
10.1101/2025.06.30.661942 — biochemistry — Posted on 2025-07-03
2216 Quantitative ethology of schistosome miracidia characterizes a conserved snail peptide that inhibits penetration
Horejsi, R. V.; Nelson, C. N.; De Ruyter, A.; Gensch, H.; Maasz-Seawright, S.; Weber, C.; Willett, S.; Olson, S. A.; Wheeler, N. J.
10.1101/2025.07.02.662618 — animal behavior and cognition — Posted on 2025-07-03
2217 Megabase-scale detachment of genome-nuclear lamina interactions is required for efficient repair of double stranded breaks
Vergara, X.; Manjon, A. G.; Novais-Cruz, M.; de Haas, M.; Ouchene, A.; van Schaik, T.; Manzo, S. G.; Cardoso da Silva, R.; Baubec, T.; van Steensel, B.; Medema, R. H.
10.1101/2025.07.03.662902 — cell biology — Posted on 2025-07-03
2218 Beyond the ink: cellular and molecular effects of iron-based pigments on macrophages
Vitipon, M.; Akingbagbohun, E.; Devime, F.; Diemer, H.; Hirschler, A.; Fenel, D.; Ravanel, S.; CARAPITO, C.; Rabilloud, T.
10.1101/2025.06.30.662256 — immunology — Posted on 2025-07-03
2220 A scalable organoid model of urothelial aging for metabolic interrogation, infection modeling, and reversal of age-associated changes
Parab, A. R.; Salazar, A. M.; Bark, S. J.; Divenko, M.; Putluri, V.; Lieu, D.; Singh, A.; Putluri, N.; Mysorekar, I. U.
10.1101/2025.06.27.662009 — bioengineering — Posted on 2025-07-03
2221 A Patient-Specific 3D Printed Carotid Artery Model Integrating Vascular Structure, Flow and Endothelium Responses
Amaya Catano, J. A.; Ong, L. J. Y.; Yuan, M.; Qu, Y.; Benitez, J.; Yarlagadda, P. K.; Toh, Y.-C.; Li, Z.
10.1101/2025.06.29.661865 — bioengineering — Posted on 2025-07-03
2222 QUANTITATIVE PROTEOMICS OF PLASMA EXTRACELLULAR VESICLES REVEALS A TTR - PLASMINOGEN NETWORK IN ATTR CARDIAC AMYLOIDOSIS
Zaroui, A.; Habert, D.; Vallee, B.; Kharoubi, M.; Fellahi, S.; Vingert, B.; Seve, M.; Cascone, I.; Audard, V.; Itti, E.; Abroud, H.; Galat, A.; Damy, T.; Bourgoin-Voillard, S.; Molinier-Frenkel, V.
10.1101/2025.06.28.662124 — biochemistry — Posted on 2025-07-03
2224 Symbiotic entrenchment through ecological Catch-22
Naragon, T. H.; Viliunas, J. W.; Yousefelahiyeh, M.; Bruckner, A.; Wagner, J. M.; Ryon, H. M.; Collinson, D.; Kitchen, S. A.; Wijker, R. S.; Sessions, A. L.; Parker, J.
10.1101/2025.07.02.662832 — evolutionary biology — Posted on 2025-07-03
2225 Mechanical Coordination of Intestinal Cell Extrusion by Supracellular 3D Force Patterns
Matejcic, M.; Wang, M.; Lopez Serrano, E.; Perez-Gonzalez, C.; Houtekamer, R.; Ceada, G.; Roca-Cusachs, P.; Gloerich, M.; Trepat, X.
10.1101/2025.07.03.661686 — cell biology — Posted on 2025-07-03
2226 Isolation Methods of Tumor Endothelial Cells Impact AngiomiR Profiles
Pecot, C. V.; Edatt, L.; Dixit, G.; Azam, S. H.; Tsai, Y. S.; Dudley, A. C.
10.1101/2025.06.25.661572 — molecular biology — Posted on 2025-07-03
2227 Bedaquiline Amplifies Proteasome Inhibitor Efficacy and Overcomes Resistance in Multiple Myeloma
Cumerlato, M.; Maccagno, M.; Labrador, M.; Luciano, B.; Mereu, E.; Porro, M.; Bandini, C.; Maisano, D.; D'Agostino, M.; Larocca, A.; Gay, F. M.; Tamburrini, A.; Anselmi, F.; Porporato, P. E.; Oliviero, S.; Bruno, B.; Morelli, E.; Munshi, N.; PIVA, R.
10.1101/2025.06.29.661768 — cancer biology — Posted on 2025-07-03
2228 Foundation Model Attributions Reveal Shared Inflammatory Program Across Diseases
Gold, M. P.; Reyes, M.; Diamant, N.; Kuo, T.; Hajiramezanali, E.; Newburger, J. W.; Son, M. B. F.; Lee, P. Y.; Scalia, G.; BenTaieb, A.; Kapadia, S. B.; Tripathi, A.; Corrada Bravo, H.; Heimberg, G.; Biancalani, T.
10.1101/2025.06.14.659567 — bioinformatics — Posted on 2025-07-03
2237 Deconstructing the common anteroposterior organisation of adult bilaterian guts
Vianello, S. D.; Lin, C.-Y.; Pinem, W. C.; Li, H.-R.; Li, K.-L.; Sonia, G.; Lee, S.-H.; Wu, S.-K.; Laudet, V.; Su, Y.-H.; Yu, J.-K.; Schneider, S. Q.
10.1101/2025.07.02.662275 — developmental biology — Posted on 2025-07-03
2238 Genetics of growth rate in induced pluripotent stem cells
Lee, B. N.; Taylor, H. J.; Cipriani, F.; Narisu, N.; Robertson, C. C.; Swift, A. J.; Sinha, N.; Yan, T.; Bonnycastle, L. L.; Dale, N.; Butt, A.; Parsaud, H.; Semrau, S.; NYSCF Global Stem Cell Array Team, ; GENESiPS Consortium, ; iPSCORE Consortium, ; Knowles, J. W.; Carcamo-Orive, I.; D'Antonio-Chronowska, A.; Frazer, K. A.; Biesecker, L. G.; Noggle, S.; Erdos, M. R.; Paull, D.; Collins, F. S.; Taylor, D. L.
10.1101/2025.07.02.662844 — developmental biology — Posted on 2025-07-03
2239 Epidermal Stem Cells Control Periderm Injury Repair via Matrix-Driven Specialization of Intercellular Junctions
He, H. M.; Boraas, L. C.; Bell, J. M.; Gong, X.; Iannaccone, S. L.; Wen, Z.; Carson, M.; Mak, M.; Sumigray, K.; Nicoli, S.
10.1101/2025.07.02.662640 — developmental biology — Posted on 2025-07-03
2240 12-Hydroxystearic acid induces epidermal keratinocytes to secrete antimicrobial peptides that are potent inhibitors of viral infection.
Gangte, O. M.; Nandy, K.; Bhatt, T.; Grewall, A.; Kulkarni, A.; Garg, V.; Ashok, A.; Mukherjee, S.; Wasker, M.; Pathak, S.; Kumar, N.; Sanzgiri, V.; Jayasekera, H.; Ghatlia, N.; Majumdar, A.; Jamora, C.
10.1101/2025.07.01.662536 — cell biology — Posted on 2025-07-03
2241 Preliminary Evidence for Anxiety-Linked Neural Sensitivity to Emotional Faces Using Fast Periodic Visual Stimulation
Vandenheever, D.; Davidson, H.; Kemp, J.; Murphy, Z.; Kujawa, A.; Shi, C.; Nadorff, M. R.; Bates-Brantley, K.; Sidwell, M.
10.1101/2025.02.15.638321 — neuroscience — Posted on 2025-07-03
2242 A compendium of nonredundant short Polymerase III promoters for CRISPR applications
Deguchi, M.; Sinclair, K. M.; Patel, A.; Coile, M.; Ortega, M. A.; Bewg, W. P.; Tsai, C.-J.
10.1101/2024.12.25.630128 — plant biology — Posted on 2025-07-03
2244 CIT tumor lines: A novel series of immunogenic cutaneous squamous cell carcinoma cell lines derived from chemical carcinogenesis
Letchworth, R.; Tanaka, M.; Barnes, A. A.; Lum, L.; Hughes, S.; Schlauderaff, G.; Chaudhary, P.; Ng, K. M.; Superville, D.; Martinez Luna, C.; Gonzalez, M.; Deacon, D. C.; Grossman, A.; Reeves, M.
10.1101/2025.04.03.647071 — cancer biology — Posted on 2025-07-03
2245 Multimodal Validation of the Existence of Transitional Cerebellar Progenitors in the Human Fetal Cerebellum
Luo, Z.; Xia, M.; Zhang, F.; Xin, D.; Rao, R.; Kiang, K.; Berry, K.; Xiong, Y.; Liu, H.; Lin, Y.; Hu, M.; Xin, M.; Ma, J.; Li, H.; Taylor, M. D.; Zhou, W.; Lu, Q. R.
10.1101/2025.06.01.657310 — developmental biology — Posted on 2025-07-03
2246 Membrane binding properties of the cytoskeletal protein bactofilin
Liu, Y.; Karmakar, R.; Billini, M.; Steinchen, W.; Mukherjee, S.; Hernandez-Tamayo, R.; Heimerl, T.; Bange, G.; Schafer, L. V.; Thanbichler, M.
10.1101/2024.06.14.599034 — microbiology — Posted on 2025-07-03
2251 MORC2 directs transcription-dependent CpG methylation of human LINE-1 transposons in early neurodevelopment
Dorazehi, F.; Francesconi, C.; Pandiloski, N.; Castilla-Vallmanya, L.; Albecka, A.; Koutounidou, S.; Mohan, S. B.; Adami, A.; Katsikas, A.; Matijevic, J.; Karlsson, O.; Davis-Hansson, C.; Johansson, J. G.; Modis, Y.; Jakobsson, J.; Douse, C. H.
10.1101/2025.06.11.658943 — molecular biology — Posted on 2025-07-03
2253 Resistance of E2F4DN to p38MAPK phosphorylation attenuates DNA damage-induced neuronal death via Cited2
Llabres-Mas, A. M.; Lopez-Sanchez, N.; Garrido-Garcia, A.; Cano-Daganzo, V.; Frade, J. M.
10.1101/2024.10.29.620791 — neuroscience — Posted on 2025-07-03
2254 Jaxley: Differentiable simulation enables large-scale training of detailed biophysical models of neural dynamics
Deistler, M.; Kadhim, K. L.; Pals, M.; Beck, J.; Huang, Z.; Gloeckler, M.; Lappalainen, J. K.; Schröder, C.; Berens, P.; Goncalves, P. J.; Macke, J. H.
10.1101/2024.08.21.608979 — neuroscience — Posted on 2025-07-03
2255 Addressing cultural and knowledge barriers to enable preclinical sex inclusive research
Gaskill, B. N.; Phillips, B.; Ho, J.; Rafferty, H.; Olajide Onada, O.; Rooney, A.; Ahluwalia, A.; Karp, N. A.
10.1101/2025.03.18.643949 — scientific communication and education — Posted on 2025-07-03
2258 Social hierarchy and behavioral individuality in colonies of isogenic female mice
Conabady, E.; Vernochet, C.; Gulmez, A.; Marti, F.; Faure, P.; Parnaudeau, S.; Tronche, F.
10.1101/2025.06.25.660781 — animal behavior and cognition — Posted on 2025-07-03
2259 NewtCap: an efficient target capture approach to boost genomic studies in Salamandridae (True Salamanders and Newts)
de Visser, M. C.; France, J.; McCartney-Melstad, E.; Bucciarelli, G. M.; Theodoropoulos, A.; Shaffer, H. B.; Wielstra, B.
10.1101/2024.10.25.620290 — genomics — Posted on 2025-07-03
2263 Mind the Gap: An Embedding Guide to Safely Travel in Sequence Space
Wu, A.; Trolliet, Q.; Rajendran, A.; Lala, J.; Angioletti-Uberti, S.
10.1101/2025.06.19.660524 — synthetic biology — Posted on 2025-07-03
2265 Structure and quenching of a bundle-shaped phycobilisome
Burtseva, A. D.; Slonimskiy, Y. B.; Baymukhametov, T. N.; Sinetova, M. A.; Gvozdev, D. A.; Tsoraev, G. V.; Cherepanov, D. A.; Maksimov, E. G.; Popov, V. O.; Boyko, K. M.; Sluchanko, N. N.
10.1101/2025.06.10.658930 — biochemistry — Posted on 2025-07-03
2266 Redundant prefrontal hemispheres adapt storage strategy to working memory demands
Tschiersch, M.; Umakantha, A.; Williamson, R. C.; Smith, M. A.; Barbosa, J.; Compte, A.
10.1101/2025.01.15.633176 — animal behavior and cognition — Posted on 2025-07-03
2268 Antagonism between bacteriophages and macrophages decreases efficacy of a phage cocktail and increases bacteriophage resistance
Castledine, M.; Szczutkowska, Z.; Matthews, A.; Walsh, S. K.; Lewis, R.; Kay, S.; Willment, J. A.; Brown, G. D.; Buckling, A.
10.1101/2025.05.16.654446 — evolutionary biology — Posted on 2025-07-03
2269 No association between metabolic rate and an exaggerated sexually selected trait
Matsumura, K.; Noda, T.; Sharma, M. D.; Okada, K.; Miyatake, T.; Hosken, D. J.
10.1101/2025.04.29.651352 — ecology — Posted on 2025-07-03
2271 Multi-task machine learning reveals the functional neuroanatomy fingerprint of mental processing
Wang, Z.; Chen, Y.; Pan, Y.; Yan, J.; Mao, W.; Xiao, Z.; Cao, G.; Toussaint, P.-J.; Guo, W.; Zhao, B.; Sun, H.; Zhang, T.; Evans, A. C.; Jiang, X.
10.1101/2023.11.30.569385 — neuroscience — Posted on 2025-07-03
2276 Divergence between transcriptomes and chromatin accessibility during differentiation from a bipotential progenitor cell population to erythroblasts and megakaryocytes
Mishra, T.; Giardine, B. M.; Morrissey, C. S.; Keller, C. A.; Heuston, E. F.; Anderson, S. M.; Paralkar, V. R.; Pimkin, M.; Weiss, M. J.; Bodine, D. M.; Hardison, R. C.
10.1101/2025.06.30.662383 — genomics — Posted on 2025-07-03
2277 Hybridization load introduced by Alpine ibex hybrid swarms
Cilingir, F. G.; Landuzzi, F.; Brambilla, A.; Charrance, D.; Furia, F.; Trova, S.; Peracino, A.; Camenisch, G.; Waldvogel, D.; Howard-McCombe, J.; Castillo De Spelorzi, Y. C.; Henzen, E.; Bernagozzi, A.; Coppe, A.; Christille, J. M.; Vecchi, M.; Vozzi, D.; Cavalli, A.; Bassano, B.; Gustincich, S.; Croll, D.; Pandolfini, L.; Grossen, C.
10.1101/2024.06.24.599926 — evolutionary biology — Posted on 2025-07-03
2278 Altered basal forebrain regulation of intrinsic brain networks in depressive and anxiety disorders
Jamieson, A. J.; Steward, T.; Davey, C. G.; Ince, S.; Agathos, J. A.; Moffat, B. A.; Glarin, R. K.; Felmingham, K. L.; Harrison, B. J.
10.1101/2024.11.06.622349 — neuroscience — Posted on 2025-07-03
2279 CLONEID: A Framework for Longitudinal Integration of Phenotypic and Genotypic Data to Monitor and Steer Subclonal Dynamics
Veith, T.; Beck, R. J.; Tagal, V.; Li, T.; Alahmari, S.; Cole, J.; Hannaby, D.; Kyei, J.; Yu, X.; Maksin, K.; Schultz, A.; Lee, H.; El Naqa, I.; Eschrich, S. A.; Ji, H.; Diaz, A.; Andor, N.
10.1101/2025.05.07.652202 — bioinformatics — Posted on 2025-07-03
2281 Decoding cnidarian cell type gene regulation
Elek, A.; Iglesias, M.; Mahieu, L.; Zolotarov, G.; Grau-Bove, X.; Aerts, S.; Sebe-Pedros, A.
10.1101/2025.07.01.662323 — genomics — Posted on 2025-07-03
2286 Phototactic Decision-Making by Micro-Algae
Raikwar, S.; Al-Kassem, A.; Gov, N. S.; Pesci, A.; Jeanneret, R.; Goldstein, R. E.
10.1101/2025.07.02.662716 — biophysics — Posted on 2025-07-03
2288 Two parallel lineage-committed progenitors contribute to the developing brain
Dundes, C. E.; Jokhai, R. T.; Ahsan, H.; Kang, R. S.; Salomon-Shulman, R. E. A.; Rajan, A.; Kim, Y. S.; Stanton, L. J.; Xu, C.; Do, S.; McDonald, B. D.; Lopez, J. M. A.; Urrutia, H. A.; Greenfeld, H.; Wong, A.; Qu, Y.; Petkovic, A. S.; Miao, Y.; Garcia, K. C.; Monje, M.; Wagner, D. E.; Bronner, M. E.; Lowe, C. J.; Loh, K. M.
10.1101/2025.07.02.662771 — developmental biology — Posted on 2025-07-03
2289 Elimination of senescent cells with senolytic host-directed therapy reduces tuberculosis progression in mice
Bishai, W.; Shee, S.; Martinez-Martinez, Y. B.; Koleske, B.; Yabaji, S. M.; Kobzik, L.; Kramnik, I.
10.1101/2025.03.28.645957 — microbiology — Posted on 2025-07-03
2290 Mitochondrial fission controls astrocyte morphogenesis and organization in the cortex
Salazar, M. P. R.; Kolanukuduru, S.; Ramirez, V.; Lyu, B.; Manigault, G.; Sejourne, G.; Sesaki, H.; Yu, G.; Eroglu, C.
10.1101/2024.10.22.619706 — cell biology — Posted on 2025-07-03
2291 Oxytocin neurons signal state-dependent transitions from rest to thermogenesis and behavioral arousal in social and non-social settings
Vandendoren, M.; Landen, J. G.; Rogers, J. F.; Killmer, S.; Alimiri, B.; Pohlman, C.; Tattersall, G. J.; Bedford, N. L.; Nelson, A. C.
10.1101/2024.10.22.619715 — neuroscience — Posted on 2025-07-03
2292 Soleus H-Reflex Up-Conditioning during Sciatic Nerve Regeneration in Rats Improves Recovery of Locomotion
Chen, Y.; Wang, Y.; Chen, L.; Yang, X.; Gemoets, D. E.; Carp, J. S.; Chen, X. Y.; Wolpaw, J. R.
10.1101/2024.12.09.627519 — neuroscience — Posted on 2025-07-03
2294 Hair Bundle Degeneration is a Key Contributor to Age-Related Vestibular Dysfunction
Kulasooriya, S.; Liu, H.; Vijayakumar, S.; Bloom, C.; Tu, S.; Borgmeier, B.; Zhou, M.; Tao, L.; Kachar, B.; He, D. Z.
10.1101/2025.02.02.636113 — neuroscience — Posted on 2025-07-03
2295 Quantifying food competition between two demersal fish species from spatiotemporal stomach content data
Lindmark, M.; Maioli, F.; Anderson, S. C.; Gogina, M.; Bartolino, V.; Skold, M.; Ohlsson, M.; Eklof, A.; Casini, M.
10.1101/2024.04.22.590538 — ecology — Posted on 2025-07-03
2296 A stress-dependent postembryonic role for the core CPA factor CFIM-1 in germline integrity
Sathaseevan, A.; Ahluwalia, R.; Yu, B.; Makhenko-Tang, C.; Nishimura, H.; Leong, A.; Kwan, K. N. N.; Derry, B.
10.1101/2025.07.01.662614 — developmental biology — Posted on 2025-07-03
2297 From Development to Regeneration: Insights into Flight Muscle Adaptations from Bat Muscle Cell Lines
Deng, F.; Pena, V.; Morales-Sosa, P.; Bernal-Rivera, A.; Yang, B.; Ghosh, S.; Castellano, L.; Katt, M.; Huang, S.; Maddera, C.; Yu, Z.; Rohner, N.; zhao, c.; Camacho, J.
10.1101/2025.07.01.662643 — cell biology — Posted on 2025-07-03
2300 Single-oocyte transcriptional profile of early-stage human oocytes reveals differentially expressed genes in the primordial and transitioning stages.
Machlin, J. H.; Hannum, D. F.; Jones, A. S.; Schissel, T.; Potosky, K.; Marsh, E.; Hammoud, S.; Padmanabhan, V.; Li, J.; Shikanov, A.
10.1101/2025.07.01.662667 — cell biology — Posted on 2025-07-03
2301 Cholesteryl esters and high protein-to-lipid ratios distinguish Non-Vesicular Extracellular Particles from Extracellular Vesicles
Ghosal, S.; Leporati, R.; Varga, A.; Susanszki, P.; Fekete, N.; Laszlo, T.; Barkai, T.; Grebecz, F. K.; Khamari, D.; Magyar, T. Z.; Hoering, M.; Vukman, K. V.; Bodnar, B. R.; Kestecher, B. M.; Fattah, M. A.; Bodor, C.; Maleth, J.; Liebisch, G.; Orso, E.; Buzas, E. I.; Osteikoetxea, X.
10.1101/2025.07.01.662358 — cell biology — Posted on 2025-07-03
2305 cPLA2α Targeting to Exosomes Connects Nuclear Deformation to LTB4-Signaling During Neutrophil Chemotaxis
Arya, S. B.; Jordan-Javed, F.; Loesel, K.; Choi, Y.; Collie, S. P.; Hein, L. E.; Baker, B.; Yoon, E.; Parent, C.
10.1101/2025.07.02.662855 — cell biology — Posted on 2025-07-03
2307 Spatio-temporal mass spectrometry in living cells reveals regulators of cuproptosis
Yang, X.; Wei, C.; Lu, Y.; Liu, X.; Shao, G.; Zhang, S.; Zheng, K.; Dai, X.; Kang, J.; Sha, C.; Zhang, Q.; Fu, C.
10.1101/2025.07.01.662679 — cell biology — Posted on 2025-07-03
2308 Hierarchical Coordination of Polymerase Theta and RAD51 Resolves Clustered Replication Fork Collapse
Smith, C.; Simpson, D. A.; Guerra, P.; Feng, W.; Ellington, S. W.; Lu, D.; Fijen, C.; Boylston, N. M.; Chriuevella, K. K.; El-Shiekh, I.; Lee, R.; Wozny, A.-S.; Pregnall, A. M.; Eckenroth, B. E.; El-Sagheer, A. H.; Brown, T.; Doublie, S.; Ramsden, D. A.; Rothenberg, E.; Nik-Zainal, S.; Gupta, G. P.
10.1101/2025.07.02.662846 — cell biology — Posted on 2025-07-03
2310 High-fat diet ablates an insulin-responsive pool of GLUT4 glucose transporters in skeletal muscle
Hu, Y.; Brown, S. N.; Nasiri, A.; Li, D. T.; Wang, H.; Cartee, G. D.; Shulman, G. I.; Bogan, J. S.
10.1101/2025.06.29.662135 — physiology — Posted on 2025-07-03
2311 Multiparametric Correlative Topographical and Volumetric Fluorescence Microscopy
Hong, W.; Zhang, Z.; Li, A.; Sun, T.; Wu, Y.; Vadukul, D. M.; Jones, D.; Li, B.; Liu, F.; Aprile, F. A.; Gorelik, J.; Klenerman, D.; Shevchuk, A.
10.1101/2025.07.01.662543 — biophysics — Posted on 2025-07-03
2313 Why are so many fusogens rod-shaped?
Butu, I. C.; Zeng, J.; An, D.; McDargh, Z. A.; Duan, K.; O'Shaughnessy, B.
10.1101/2025.06.30.662463 — biophysics — Posted on 2025-07-03
2314 Multiscale wrinkling dynamics in epithelial shells
Chahare, N.; Ouzeri, A.; Wilson, T.; Bal, P. K.; Golde, T.; Vilanova, G.; Pujol-Vives, P.; Roca-Cusachs, P.; Trepat, X.; Arroyo, M.
10.1101/2025.06.30.662426 — biophysics — Posted on 2025-07-03
2315 PCNA is a Nucleotide Exchange Factor for the Clamp Loader ATPase Complex
Pajak, J.; Landeck, J. T.; Liu, X.; Anand, K.; Litvak, S.; Kelch, B. A.
10.1101/2025.07.02.662830 — biochemistry — Posted on 2025-07-03
2318 Preclinical Efficacy of Tasquinimod in Myelodysplastic Neoplasms: Restoring Erythropoiesis and Mitigating Bone Loss
Wobus, M.; Weidner, H.; Wehner, R.; Baumann, A.-L.; Moebus, K.; Balaian, E.; Toerngren, M.; Vahtola, E.; Eriksson, H.; Winter, S.; Platzbecker, U.; Chavakis, T.; Hofbauer, L. C.; Rauner, M.; Bornhaeuser, M.; Sockel, K.
10.1101/2025.07.01.660147 — cell biology — Posted on 2025-07-03
2320 A GCN1-independent activator of the kinase GCN2
Zhu, J.; Emanuelli, G.; Masson, G.; Vinciauskaite, V.; Willems, H.; Lim, A.; Brown, C. A.; Winpenny, D.; Clarke, M.; Gilley, R.; Preston, F.; Wilson, J.; Bader, A.; Rahman, T.; Chambers, J. E.; Skidmore, J.; Morrell, N.; Marciniak, S. J.
10.1101/2025.06.29.662197 — cell biology — Posted on 2025-07-03
2321 Activation of the impaired NAMPT/SIRT7/SOD2 axis restores alveolar progenitor cell homeostasis in idiopathic pulmonary fibrosis and reverses pulmonary fibrosis in mice
Zhang, X.; Liu, X.; Qiao, Y.; Rabata, A.; Liu, N.; Yao, C.; Parimon, T.; Chen, D.; Chen, P.; Stripp, B.; Gardell, S. J.; Jiang, D.; Noble, P.; Liang, C. J.
10.1101/2025.06.30.662456 — cell biology — Posted on 2025-07-03
2322 Human Urine-derived SIX2-positive renal progenitor cells improve kidney injury in an IRI mouse model
Kordes, C.; Spitzhorn, L. S.; Bohndorf, M.; Ncube, A.; Thimm, C.; Erichsen, L.; Wruck, W.; Adjaye, J.
10.1101/2025.07.02.662781 — cell biology — Posted on 2025-07-03
2326 Metabolic control of enteroendocrine cell fate through a redox state sensor CtBP
Rovenko, B. M.; Moisio, K.; Biehler, C.; Girych, M.; Hallasaari, A.; Deniz, O.; Bluhm, S.; Viitanen, A.; Kokki, K.; Fabris, G.; Yang, Y.; Cracan, V.; Miguel-Aliaga, I.; Hietakangas, V.
10.1101/2025.06.30.662346 — physiology — Posted on 2025-07-02
2336 Aqueous two-phase bioinks for discrete packing and compartmentalisation of 3D bioprinted cells
Marcotulli, M.; Iacomino, A.; Serpe, F.; Iafrate, L.; Bastioli, M.; Montalbano, G.; Palmisano, B.; Franco, S.; Angelini, R.; Corsi, A.; Riminucci, M.; Ruocco, G.; Scognamiglio, C.; Barbetta, A.; Cidonio, G.
10.1101/2025.06.27.661968 — bioengineering — Posted on 2025-07-02
2337 Development of a Clinically Relevant Rabbit Model of Acute Laryngeal Injury
Stepp, R.; Ali, N.; Rodriguez, A. A.; Nicklow, E.; Thornton, N.; Reddy, A.; Kenney, H.; Cottler, P. S.; Griffin, D. R.; Daniero, J. J.
10.1101/2025.06.27.662000 — bioengineering — Posted on 2025-07-02
2338 Structural basis for TORC2 activation
Zou, L.; Tettamanti, M. G.; Bergmann, A.; Loewith, R.; Tafur, L.
10.1101/2025.07.02.662585 — biochemistry — Posted on 2025-07-02
2340 Human mitochondrial DNA variants influence telomere length: evidence from a transmitochondrial cybrid model
Mahieu, M.; Defour, J.-P.; Mathieu, B.; Richiardone, E.; Heremans, I.; Levy, G.; Le Berre, G.; Scheers, I.; Brichard, B.; Arnould, T.; Bommer, G.; Gallez, B.; Corbet, C.; Decottignies, A.
10.1101/2025.06.27.661964 — cell biology — Posted on 2025-07-02
2349 Microbiome evolution plays a secondary role in host rapid adaptation
Shahmohamadloo, R. S.; Gabidulin, A. R.; Andrews, E. R.; Rudman, S. M.
10.1101/2025.06.27.661976 — evolutionary biology — Posted on 2025-07-02
2350 Distribution patterns of invasive alien plant species in mainland Portugal
Fernandes, R.; Castro, A.; Marchante, H.; Marchante, E.; Capinha, C.
10.1101/2025.06.27.661711 — ecology — Posted on 2025-07-02
2352 ChAHP Silences SINE Retrotransposons by Inhibiting TFIIIB Recruitment
Schnabl-Baumgartner, J.; Mohn, F.; Schwaiger, M.; Ahel, J.; Steiner, J.; Shimada, Y.; Aluri, S.; Buhler, M.
10.1101/2025.07.02.662776 — molecular biology — Posted on 2025-07-02
2354 Multiplexed single-cell transcriptomics reveals diverse phenotypic outcomes for pathogenic SHP2 variants
van Vlimmeren, A. E.; Giglio, R. M.; Jiang, Z.; Lee, M.; McFaline-Figueroa, J. L.; Shah, N. H.
10.1101/2025.06.30.662374 — molecular biology — Posted on 2025-07-02
2357 Sub-clinical exposure to Streptococcus pyogenes drives the development of immunity
Lepletier, A.; Vedis, D.; Ozberk, V.; Anugraham, M.; Bassette, D.; Calcutt, A.; Frost, H.; Azzopardi, K. I.; Steer, A. C.; Kalarich, D.; Osowicki, J.; Good, M. F.; Pandey, M.
10.1101/2025.07.02.662868 — microbiology — Posted on 2025-07-02
2358 Mycelium of mushroom-producing fungi as high-quality protein source
Zwinkels, J.; van de Koolwijk, P.; van der Wielen, N.; van Mastrigt, O.; Smid, E. J.
10.1101/2025.07.02.662711 — microbiology — Posted on 2025-07-02
2359 Anthrax toxin receptor 2 is the Receptor for Clostridium perfringens NetF: Structural Insights into Toxin Binding and Pore Formation
Chang, W.; Cattalani, F.; Iacovache, I.; Naguleswaran, A.; Farhoosh, F.; Franzen, J.; Abrami, L.; van der Goot, F. G.; Posthaus, H.; Zuber, B.
10.1101/2025.07.02.662835 — microbiology — Posted on 2025-07-02
2360 ETS-guided iPSC-endothelial models recapitulate malaria pathogenesis
Korbmacher, F.; Fleckenstein, H.; Long, R. K. M.; Polinski, P.; Piatti, L.; Lopez Gutierrez, B.; Batzilla, A.; Crusius, D.; Trivedi, V.; Ebisuya, M.; Bernabeu, M.
10.1101/2025.07.01.662615 — microbiology — Posted on 2025-07-02
2362 Nodamuravirus protein B2 boosts self-amplifying mRNA efficacy by overcoming innate immune barriers.
Sanchez-David, R. Y.; Le, H. D.; Nemegeer, J.; Goncalves, A.; Merits, A.; Maillard, P. V.
10.1101/2025.06.27.661928 — immunology — Posted on 2025-07-02
2364 PD-L1 ligation on NK cells induces a metabolic shift from glycolysis to fatty acid oxidation, enhancing tumor infiltration and control
Srpan, K.; Lupo, K.; Sottile, R.; Scarno, G.; Lawry, C.; Kolk, G.; Shaffer, B.; Patel, S. G.; Al-Niaimi, A.; Lau, C. M.; Sun, J.; Hsu, K. C.
10.1101/2025.06.27.661921 — immunology — Posted on 2025-07-02
2365 Tissue architecture dynamics underlying immune development and decline in the thymus
Liu, S.; Friedrich, M. J.; Raichur, R.; Gong, D.; Kehl, N.; Gong, Q.; Chen, B.; Gustafsson, K.; Ma, L. L.; Scadden, D. T.; Macrae, R. K.; Zhang, F.; Chen, F.
10.1101/2025.06.28.662120 — immunology — Posted on 2025-07-02
2366 Transcriptomic signatures of nine high-risk neuropsychiatric copy number variants in human brain cells
Dugan, G.; Akula, N.; Marenco, S.; Auluck, P.; Raznahan, A.; Liu, S.; DeCasien, A. R.; Xu, Q.; Feng, N.; Kolachana, B.; Jiang, X.; Gregory, M.; Berman, K.; Hoffman, G.; Roussos, P.; McMahon, F.; Schulmann, A.
10.1101/2024.09.19.613680 — genetics — Posted on 2025-07-02
2367 Molecular Subtyping Based on Hippocampal Cryptic Exon Burden Reveals Proteome-wide Changes Associated with TDP-43 Pathology across the Spectrum of LATE and Alzheimer's Disease
Trautwig, A. N.; Shantaraman, A.; Chung, M.; Dammer, E. B.; Ping, L.; Duong, D. M.; Petrucelli, L.; Ward, M. E.; Glass, J. D.; Nelson, P. T.; Levey, A. I.; McEachin, Z. T.; Seyfried, N. T.
10.1101/2025.05.30.656396 — neuroscience — Posted on 2025-07-02
2368 Foveated metamers of the early visual system
Broderick, W. F.; Rufo, G.; Winawer, J.; Simoncelli, E.
10.1101/2023.05.18.541306 — neuroscience — Posted on 2025-07-02
2369 ATG8i Autophagy activation is mediated by cytosolic Ca2+ under osmotic stress in Arabidopsis thaliana
Castillo-Olamendi, L.; Gutierrez-Martinez, J.; Jimenez-Nopala, G.; Galindo, A.; Barrera-Ortiz, S.; Rosas-Santiago, P.; Cordoba, E.; Leon, P.; Porta, H.
10.1101/2025.07.02.662772 — plant biology — Posted on 2025-07-02
2370 Visible traits demonstrate that crispant founder mice can be used for phenotypic assessment
Tillotson, R.; Gertsenstein, M.; Chang, L.-H.; Ruston, J.; Bellido Molias, F.; Lintott, L. G.; Taylor, C.; Gautier, P.; Nutter, L. M.; Justice, M. J.
10.1101/2025.06.27.661753 — genetics — Posted on 2025-07-02
2375 Lonafarnib Partially Reverses Cardiac Senescence in Human and Mouse Progeria Models via Autophagy Activation
Monteiro, L. M.; Pitrez, P. R.; Correira-Santos, S.; Dark, N.; Santinha, D.; Aveleira, C.; Townsend, M.; Taylor, J.; Nissan, X.; Sardao, V.; Cortes, L.; Mitter, R.; Marino, A.; Sousa-Soares, C.; Ribeiro, R.; Smith, J. C.; Logarinho, E.; Ori, A.; Bernardo, A. S.; Ferreira, L.
10.1101/2025.06.27.661680 — cell biology — Posted on 2025-07-02
2376 Dexamethasone impairs glycolysis but improves mycobacterial killing in primary human macrophages
Thong, L.; Sandby Thomas, O.; O Gallchobhair, O.; Duffin, E.; Yennemadi, A. S.; Leisching, G.; Murphy, D. M.; Nadarajan, P.; O Connell, F.; O Sullivan, M. P.; Basdeo, S. A.; Cox, D. J.; Keane, J.
10.1101/2025.06.27.661762 — immunology — Posted on 2025-07-02
2378 Tinnitus perception is linked to arousal system dysfunction
Hobeika, L.; Masson, R.; Dupont, S.; Londero, A.; Samson, S.
10.1101/2025.07.01.662596 — neuroscience — Posted on 2025-07-02
2379 A global genetic interaction map of a human cell reveals conserved principles of genetic networks
Billmann, M.; Costanzo, M.; Zhang, X.; Hassan, A. Z.; Rahman, M.; Brown, K. R.; Chan, K. S.; Tong, A. H.; Pons, C.; Ward, H. N.; Ross, C.; van Leeuwen, J.; Aregger, M.; Lawson, K. A.; Mair, B.; Roth, A. F.; Sen, N. E.; Forster, D. T.; Tan, G.; Merro, P.; Masud, S. N.; Lee, Y.; Aguilera-Uribe, M.; Usaj, M.; Almeida, S. M.; Aulakh, K.; Bhojoo, U.; Birkadze, S.; Budijono, N.; Cai, X.; Caumanns, J. J.; Chandrashekhar, M.; Chang, D.; Clinie, R.; Dasgupta, K.; Drazic, A.; Rojas Echenique, J. I.; Gacesa, R.; Granda Farias, A.; Habsid, A.; Horecka, I.; Kantautas, K.; Ji, F.; Kim, D.-K.; Lee, S. Y.; Li
10.1101/2025.06.30.662193 — systems biology — Posted on 2025-07-02
2380 Resolving the Foliar Calcium Mobility Paradox: Enhancing Foliar Calcium Transport in Tomato Using Osmotic Regulators
Santos, E.; Montanha, G. S.; da Silva, H. J. F. A.; da Silva, N. G. d. C.; Franco, F. S.; Brandao, J. R.; Huatatoca, K. A. C.; Virgilio, A.; Karunakaran, C.; Tanino, K. K.; Lavres, J.; Pereira De Carvalho, H. W.
10.1101/2025.07.02.662739 — plant biology — Posted on 2025-07-02
2381 Mechanical loading reveals cell type-specific responses and role of PHGDH in endothelial cell growth
Mäntyselkä, S.; Niemi, E.; Ylä-Outinen, L.; Kolari, K.; Uusitalo-Kylmälä, L.; Ortega-Alonso, A.; Liimatainen, R.-M.; Fachada, V.; Permi, P.; Kalenius, E.; Hulmi, J.; Kivelä, R.
10.1101/2025.06.27.661962 — physiology — Posted on 2025-07-02
2382 KLF5 controls subtype-independent highly interactive enhancers in pancreatic cancer to regulate cell survival
Ekstrom, T. L.; Saha, B. J.; Thiel, J.; Dai, Z.; Manjunath, M.; Schacherer, N.; Souto, Y.; Abdelrahman, A. M.; Essmann, F.; Truty, M. J.; Dong, M.; Johnsen, S. A.
10.1101/2025.06.30.662301 — cancer biology — Posted on 2025-07-02
2383 KAT6A/B inhibition synergizes with retinoic acid and enhances the efficacy of GD2-targeted immunotherapy in neuroblastoma
Weichert-Leahey, N.; Berezovskaya, A.; Zimmerman, M. W.; Alvarez-Caldero, F.; Winschel, M.; Salhotra, S.; Mabe, N. W.; Perez-Atayde, A.; Vitorino, F. N. d. L.; Garcia, B.; Gerdemann, U.; Stegmaier, K.; Durbin, A.; Oldridge, D.; Abraham, B.; Look, A. T.
10.1101/2025.07.01.662644 — cancer biology — Posted on 2025-07-02
2384 Glioblastoma cells taste temozolomide via TAS2R43
Costa, A. R.; Duarte, A. C.; Goncalves, I.; Preissner, R.; Cascalheira, J. F.; Marcelino, H.; Santos, C. R. A.
10.1101/2025.06.27.661979 — cancer biology — Posted on 2025-07-02
2387 Multimodal profiling of proinflammatory protease activity identifies caspase-1 as a target for lung cancer interception
Wang, C. S.; Zhong, Q.; Wang, S.-T.; Alonso, M. C. M.; Neaher, S.; Patel, S.; Parisi, T.; Kirkpatrick, J. D.; Sequist, L. V.; Jacks, T. E.; Bhatia, S.
10.1101/2025.07.01.662195 — bioengineering — Posted on 2025-07-02
2390 Persistent Activation of Endothelial Cells is Linked to Thrombosis and Inflammation in Cerebral Cavernous Malformation Disease
Gallego-Gutierrez, H.; Frias-Anaya, E.; Bui, C.; Zhao, L.; Hsu, E.; Indralingam, H. S.; Korbelin, J.; Trejo, J.; Steinberg, J.; Zemke, N. R.; Lopez-Ramirez, M. A.
10.1101/2025.06.29.662238 — genomics — Posted on 2025-07-02
2391 A genome-wide MAGIC kit for recombinase-independent mosaic analysis in Drosophila
Shen, Y.; Yeung, A. T.; Ditchfield, P.; Korn, E.; Clements, R.; Chen, X.; Wang, B.; Sheen, M.; Jarman, P.; Han, C.
10.1101/2025.06.30.662354 — genetics — Posted on 2025-07-02
2394 Pulsatile flow dynamics determine pulmonary arterial architecture
Spurgin, S. B.; Thai, L.; Wan, T.; Chaney, C.; Cowdin, M. A.; VERRAM REDDY, S. R.; Hussain, T.; Fares, M.; Spearman, A. D.; Cleaver, O.
10.1101/2025.06.30.662470 — cell biology — Posted on 2025-07-02
2396 Intergenerational Conditioning via Intermittent Parental Hypoxia Confers Stroke Resilience in Offspring
Caglayan, A. B.; Beker, M. C.; Felix-Ilemhenbhio, F.; Altunay, S.; Yelkenci, H. E.; Caglayan, A.; Dogan, E.; Ates, N.; Bae, O.-N.; Burrows, D. J.; Ali, A.; De Felice, M.; Kilic, E.; Majid, A.
10.1101/2025.07.02.662697 — neuroscience — Posted on 2025-07-02
2397 Cytokine control of systemic hypoxia tolerance in Drosophila.
Ding, K.; Bodkhe, P.; Lee, B.; Polan, D.; Wycislik, A.; Cheung, T.; Wu, S.; Grewal, S. S.
10.1101/2025.06.30.661614 — physiology — Posted on 2025-07-02
2401 Conformational flexibility of tubulin dimers regulates the transitions of microtubule dynamic instability
Shred, M.; Vangos, N. E.; Bayne, A. N.; Tetlalmatzi, S. C.; Peng, W.; Trempe, J.-F.; Sept, D.; Cianfrocco, M. A.; Brouhard, G.
10.1101/2025.06.30.662375 — biophysics — Posted on 2025-07-02
2403 Multi-season analysis reveals hundreds of drought-responsive genes in sorghum
Cole, B.; Zhang, W.; Shi, J.; Wang, H.; Baker, C.; Varoquaux, N.; Hollingsworth, J.; Hutmacher, R.; Dahlberg, J.; Pierroz, G.; Barry, K. W.; Singan, V.; Yoshinaga, Y.; Daum, C.; Zane, M.; Blow, M.; OMalley, R.; Shu, S.; Jenkins, J. W.; Lovell, J. T.; Schmutz, J.; Taylor, J. W.; Coleman-Derr, D.; Visel, A.; Lemaux, P. G.; Purdom, E.; Vogel, J. P.
10.1101/2025.06.27.662006 — genomics — Posted on 2025-07-02
2404 Multi-omic identification of key transcriptional regulatory programs during endurance exercise training in rats
Smith, G. R.; Zhao, B.; Lindholm, M. E.; Raja, A.; Viggars, M. R.; Pincas, H.; Gay, N. R.; Sun, Y.; Ge, Y.; Nair, V. D.; Sanford, J. A.; Amper, M. A. S.; Vasoya, M.; Smith, K. S.; Montgomery, S. B.; Zaslavsky, E.; Bodine, S. C.; Esser, K. A.; Walsh, M. J.; Snyder, M.; Sealfon, S. C.
10.1101/2023.01.10.523450 — genomics — Posted on 2025-07-02
2405 Assemblatron: An Automated Workflow for High-Throughput Assembly of Big-DNA Libraries
Gartner, A. V.; Quispe, L. F.; Ruehmann, K.-P.; Martin, J. A.; Welker, J. M.; Li, M. K.; Coelho, C.; Zhao, Y.; Brosh, R.; Boeke, J. D.
10.1101/2025.06.30.662359 — genetics — Posted on 2025-07-02
2409 Secretion and signaling properties of Wnt11 and Wnt3 are determined by their N-terminus
Voloshanenko, O.; Dhonnar, N.; Aponte-Santamaria, D.; Seidl, C.; Wolf, L.; Kranz, D.; Ivanova, A.; Figueroa Marquez, E. J.; Pokrandt, B.; Augustin, I.; Port, F.; Sinning, I.; Niehrs, C.; Bruegger, B.; Boutros, M.
10.1101/2025.07.02.662750 — cell biology — Posted on 2025-07-02
2411 SF3B1K700E rewires splicing of cell-cycle regulators
Baker, M.; Sharma, A.; Engal, E.; Petasny, M.; Jaffe-Herman, S.; Geminder, O.; Su, M.; Bentata, M.; Kay, G.; Salton, M.
10.1101/2025.05.08.652831 — molecular biology — Posted on 2025-07-02
2413 Intra- and intercellular immune responses across diverse in vitro stimuli and inflammatory disease
Wood, O.; Braithwaite, A. T.; Fisher, J.; Li, L.; Murray, L.; Paluch, C.; Jackson-Wood, M. A.
10.1101/2025.06.27.661918 — immunology — Posted on 2025-07-02
2414 Foveated metamers of the early visual system
Broderick, W. F.; Rufo, G.; Winawer, J.; Simoncelli, E.
10.1101/2023.05.18.541306 — neuroscience — Posted on 2025-07-02
2416 Barley resistance and susceptibility to fungal cell entry involve the interplay of ROP signaling with phosphatidylinositol-monophosphates
Weiss, L. S.; Bradai, M.; Bartram, C.; Heilmann, M.; Mergner, J.; Kuster, B.; Hensel, G.; Kumlehn, J.; Engelhardt, S.; Heilmann, I.; Huckelhoven, R.
10.1101/2024.11.19.624325 — plant biology — Posted on 2025-07-02
2417 The gut microbiome shapes pharmacology and treatment outcomes for a key anti-inflammatory therapy
Villa Soto, V. S.; Degraeve, A. L.; Heath, C. M.; Orellana, D. A.; Reilly, E. R.; Mukherjee, M. F.; Brockert, J. G.; Dumlao, D. S.; Blank, R. B.; Perlmutter, N.; Yu, S.; Ashouri, J.; Scher, J. U.; Patterson, A. D.; Turnbaugh, P. J.; Nayak, R. R.
10.1101/2025.06.26.661733 — pharmacology and toxicology — Posted on 2025-07-02
2418 Structure and quenching of a bundle-shaped phycobilisome
Burtseva, A. D.; Slonimskiy, Y. B.; Baymukhametov, T. N.; Sinetova, M. A.; Gvozdev, D. A.; Tsoraev, G. V.; Cherepanov, D. A.; Maksimov, E. G.; Popov, V. O.; Boyko, K. M.; Sluchanko, N. N.
10.1101/2025.06.10.658930 — biochemistry — Posted on 2025-07-02
2419 Socio-acoustic co-selection? Vocal encoding of sociability prevails over emotions in sheep bleats
Villain, A. S.; Boissy, A.; Bonnafe, G.; Durand, C. S.; Douls, S.; Renaud-Goud, P.; Mialon, M.-M.; Hazard, D.; Briefer, E. F.
10.1101/2025.06.28.662115 — animal behavior and cognition — Posted on 2025-07-02
2421 Pcbp1 constrains Oct4 expression in the context of pluripotency
Bakhmet, E. I.; Zinovyeva, A. S.; Kuzmin, A. A.; Smirnova, D. V.; Gordeev, M. N.; Petrenko, E. E.; Aksenov, N. D.; Tomilin, A. N.
10.1101/2024.09.07.611681 — cell biology — Posted on 2025-07-02
2424 Title: KymoTip: High-throughput Characterization of Tip-growth Dynamics in Plant Cells
Kang, Z.; Kimata, Y.; Nonoyama, T.; Ikeuchi, T.; Kuchitsu, K.; Satoru, T.; Ueda, M.
10.1101/2025.06.27.661917 — bioinformatics — Posted on 2025-07-02
2426 Perplexity as a Metric for Isoform Diversity in the Human Transcriptome
Schertzer, M. D.; Park, S. H.; Su, J.; Sheynkman, G. M.; Knowles, D. A.
10.1101/2025.07.02.662769 — genomics — Posted on 2025-07-02
2427 Reduced size of larvae and small fish linked to warming and reduced prey density
Lindmark, M.; Werner, M.; Thor, P.; Maioli, F.; Quesada, E.; Bartolino, V.; Jacobson, P.
10.1101/2025.06.27.661664 — ecology — Posted on 2025-07-02
2428 Polyamines buffer labile iron to suppress ferroptosis
Sharma, P.; Keys, H. R.; Müller, S.; Pires, I. S.; Mansell, R.; Imada, S.; Kunchok, T.; Waite, M.; Ausler, C.; Yuan, B.; Deik, A. A.; Hammond, P. T.; Rodriguez, R.; Henry, W. S.; Jain, A.
10.1101/2025.06.30.662349 — cell biology — Posted on 2025-07-02
2431 Intra- and intercellular immune responses across diverse in vitro stimuli and inflammatory disease
Wood, O.; Murray, L.; Fisher, J.; Braithwaite, A. T.; Paluch, C.; Jackson-Wood, M. A.; Li, L.
10.1101/2025.06.27.661918 — immunology — Posted on 2025-07-02
2437 A mathematical framework for human neutrophil state transitions inferred from single-cell RNA sequence data
Wigerblad, G.; Carruthers, J.; Ray, S.; Finnie, T.; Lythe, G.; Molina-Paris, C.; Pyne, S.; Kaplan, M.
10.1101/2025.06.27.662068 — cell biology — Posted on 2025-07-02
2438 Multiple sclerosis-associated HLA demarcates EBV-specific CD8+ T cells with an exhausted and brain residency phenotype
Reijm, S.; Marques, A. M.; Rip, J.; Corsten, C. E. A.; Wierenga-Wolf, A. F.; de Wit, H.; Melief, M.-J.; van Hasselt, Y.; van Langelaar, J.; Neuteboom, R.; Wokke, B. H. A.; Mueller, Y. M.; Smolders, J.; van Luijn, M. M.
10.1101/2025.06.27.661912 — immunology — Posted on 2025-07-02
2439 Cell-type-specific execution of effector-triggered immunity
Chhillar, H.; Jo, L.; Redkar, A.; Kajala, K.; Jones, J. D.; Ding, P.
10.1101/2025.06.28.662111 — plant biology — Posted on 2025-07-02
2440 cIAP1 inhibitor of apoptosis is a tumor suppressor in Ewing sarcoma
Cidre-Aranaz, F.; Geyer, F. H.; Hoelting, T. L.; Faehling, T.; Ritter, A.; Zimmermann, M.; Mao, L.; Alonso, J.; Sastre, A.; Jayavelu, A. K.; Knott, M. M.; Musa, J.; Gruenewald, T. G. P.
10.1101/2025.06.27.661947 — cancer biology — Posted on 2025-07-02
2444 Microtubule curling as an efficient readout to uncover fundamental concepts of axonal cell biology
Voelzmann, A.; Owens, M.; Beaven, R.; Cairns, W.; Elliot, A.; Feng, S.-H.; Goncaves-Pimentel, C.; Hahn, I.; Jones, E.; Norris, K.; Murphy, T.; Liew, Y.-T.; Lorenzo-Cisneros, L.; Fuelle, J.; Pinho-Correia, L. M.; Qu, Y.; Sharma, T.; Sanchez-Soriano, N.; Prokop, A.
10.1101/2025.06.27.662005 — cell biology — Posted on 2025-07-02
2445 Natural Product-Like Fragments Unlock Novel Chemotypes for a Kinase Target - Exploring Options beyond the Flatland
Santura, A.; Mueller, J.; Wolter, M.; Tutzschky, I.-C.; Ruf, M.; Metz, A.; Sandner, A.; Merkl, S.; Klebe, G.; Glinca, S.; Czodrowski, P.
10.1101/2025.06.11.659015 — molecular biology — Posted on 2025-07-02
2446 Structural and functional characterization of the antigenicity of influenza A virus hemagglutinin subtype H15
Bhavsar, D.; Leon, A. N.; Hsu, W.-L.; Puente-Massaguer, E.; Ferguson, J.; Han, J.; Wilson, P.; Ward, A.; Krammer, F.
10.1101/2025.07.01.662631 — microbiology — Posted on 2025-07-02
2447 Human gloss perception reproduced by tiny neural networks
Morimoto, T.; Akbarinia, A.; Storrs, K. R.; Cheeseman, J. R.; Smithson, H. E.; Gegenfurtner, K. R.; Fleming, R. W.
10.1101/2025.05.09.653112 — neuroscience — Posted on 2025-07-02
2449 Exosomal cargo genes as biomarkers and potential mediators of exosome-driven cell communication in Pleural Mesothelioma
Kraft, A.; Toenz, A.; Schlaepfer, F.; Ronner, M.; Orlowski, V.; Kirschner, M. B.; Felley-Bosco, E.; Bein, J.; Wild, P. J.; Boeva, V.; Opitz, I.; Meerang, M.
10.1101/2025.04.04.647264 — cancer biology — Posted on 2025-07-02
2450 Direct RNA sequencing (RNA004) allows for improved transcriptome assessment and near real-time tracking of methylation for medical applications
Hewel, C.; Wierczeiko, A.; Miedema, J.; Hofmann, F.; Weissbach, S.; Dietrich, V.; Friedrich, J.; Holthoefer, L.; Haug, V.; Muendnich, S.; Schartel, L.; Jenson, K.; Diederich, S.; Sys, S.; Butto, T.; Paul, N.; Koch, J.; Lyko, F.; Kraft, F.; Schweiger, S.; Lemke, E. A.; Helm, M.; Linke, M.; Gerber, S.
10.1101/2024.07.25.605188 — bioinformatics — Posted on 2025-07-02
2451 Characterisation of changes in the gut microbiota associated with eating disorders
Achamrah, N.; Breton, J.; Galmiche, M.; Demangeat, T.; Quillard, M.; Grigioni, S.; Folope, V.; Lelandais, H.; Coëffier, M.; Bindels, L. B.; Dechelotte, P.; Tavolacci, M.-P.; Ribet, D.
10.1101/2025.06.30.662422 — microbiology — Posted on 2025-07-02
2452 Structural Connectome Dimension Shapes Brain Dynamics in Health and Disease
Barzon, G.; Allegra, M.; Aarabi, M. H.; Pini, L.; De Domenico, M.; Corbetta, M.; Suweis, S.
10.1101/2025.06.30.662336 — neuroscience — Posted on 2025-07-02
2455 Transdiagnostic Profiles of BOLD Signal Variability in Autism and Schizophrenia Spectrum Disorders: Associations with Cognition and Functioning
Secara, M. T.; Khan, Z.; Rashidi, A.; Oliver, L. D.; Yu, J.-C.; Foussias, G.; Dickie, E. W.; Szatmari, P.; Desarkar, P.; Lai, M.-C.; Baracchini, G.; Malhotra, A. K.; Buchanan, R. W.; Voineskos, A. N.; Ameis, S. H.; Hawco, C.
10.1101/2025.06.30.662421 — neuroscience — Posted on 2025-07-02
2456 Circulating tumor cell heterogeneity and MMP9 expression in clinical correlation with breast cancer
Yi, M.; Sun, C.; Liang, M.; Liu, J.; Wei, J.; Long, J.; Zhao, H.; Liu, S.; Tang, M.; Mo, Z.; Li, X.; Yin, Y.
10.1101/2025.06.30.662312 — cancer biology — Posted on 2025-07-02
2458 Functional assessments of short-term spatial memory in the Dog Aging Project identify strong associations with age that are not moderated by body mass
Hargrave, S. H.; Keyser, A. J.; Kristal, E.; Alexander, G. E.; Block, T. A.; Bray, E. E.; Douglas, L. E. L. C.; Kennedy, B. S.; Promislow, D.; Raichlen, D. A.; Dog Aging Project Consortium, ; MacLean, E. L.
10.1101/2025.06.30.662397 — animal behavior and cognition — Posted on 2025-07-02
2459 The ciliary kinesin KIF7 controls the development of the cerebral cortex by acting differentially on SHH-signaling in dorsal and ventral forebrain
PEDRAZA, M.; GRAMPA, V.; SCOTTO-LOMASSESE, S.; PUECH, J.; MUZERELLE, A.; MOHAMMAD, A.; Lebon, S.; RENIER, N.; METIN, C.; MASSON, J.
10.1101/2024.03.21.586159 — neuroscience — Posted on 2025-07-02
2462 MOTL: enhancing multi-omics matrix factorization with transfer learning
Hirst, D.; Terezol, M.; Cantini, L.; Villoutreix, P.; Vignes, M.; Baudot, A.
10.1101/2024.03.22.586210 — bioinformatics — Posted on 2025-07-02
2465 hoodscanR: profiling single-cell neighborhoods in spatial transcriptomics data
Liu, N.; Martin, J.; Bhuva, D. D.; Chen, J.; Li, M.; Lee, S. C.; Kharbanda, M.; Cheng, J.; Mohamed, A.; Kulasinghe, A.; Polo, J. M.; Chen, Y.; Tan, C. W.; Davis, M. J.
10.1101/2024.03.26.586902 — bioinformatics — Posted on 2025-07-02
2467 Aggregation of HAPLN2, a component of the perinodal extracellular matrix, is a hallmark of physiological brain aging in mice
Watanabe, A.; Hirayama, S.; Kominato, I.; Marchese, S.; Esposito, P.; Metodieva, V.; Kimura, T.; Kameda, H.; Sano, T.; Takatori, S.; Takao, M.; Koike, M.; Varela, J. A.; Tomita, T.; Murata, S.
10.1101/2025.01.09.632092 — biochemistry — Posted on 2025-07-02
2468 A mathematical model of metacarpal subchondral bone adaptation, microdamage, and repair in racehorses
Pan, M.; Malekipour, F.; Pivonka, P.; Morrice-West, A. V.; Flegg, J. A.; Whitton, C.; Hitchens, P. L.
10.1101/2025.04.06.646486 — animal behavior and cognition — Posted on 2025-07-02
2471 An optimised computational approach for the identification of somatic structural variants in cancer
Waise, S.; Mensah, N.; Lesluyes, T.; Demeulemeester, J.; Flanagan, A. M.; Pillay, N.; Van Loo, P.
10.1101/2025.07.01.662575 — genomics — Posted on 2025-07-02
2473 Haplotype-Resolved DNA Methylation at the APOE Locus identifies Allele-Specific Epigenetic Signatures Relevant to Alzheimer's Disease Risk
Genner, R. M.; Meredith, M.; Moller, A.; Weller, C.; Daida, K.; Ayuketah, A.; Jerez, P. A.; Akeson, S.; Malik, L.; Baker, B.; Kouam, C.; Paquette, K.; Marenco, S.; Auluck, P.; Mandal, A.; Paten, B.; Reed, X.; Jain, M.; Cookson, M. R.; Singleton, A. B.; Nalls, M. A.; Blauwendraat, C.; Billingsley, K. J.
10.1101/2025.07.01.662592 — genomics — Posted on 2025-07-02
2474 Hi-reComb: constructing recombination maps from bulk gamete Hi-C sequencing
Malinsky, M.; Talbi, M.; Zhou, C.; Maurer, N. W.; Sacco, S.; Shapiro, B.; Peichel, C. L.; Seehausen, O.; Salzburger, W.; Weber, J. N.; Bolnick, D. I.; Green, R. E.; Durbin, R.
10.1101/2025.03.06.641907 — genetics — Posted on 2025-07-02
2475 SETD6 Mediates Selective Interaction and Genomic Occupancy of BRD4 and MITF in Melanoma cells
Biton, T. E.; Feldman, M.; Davidy, T.; Moskovitz, N. T.; Levin, L.; Sevilla, D.; Goding, C.; Bernstein, E.; Levy, D.
10.1101/2025.06.29.662016 — molecular biology — Posted on 2025-07-02
2476 Proteobacteria with chemosynthetic potential are highly enriched in the gills of Hypoplectrus reef fishes
Abdelghany, S.; Helmkampf, M.; Schechter, M. S.; Veseli, I. A.; Leray, M.; Eren, A. M.; Puebla, O.
10.1101/2025.07.01.662686 — microbiology — Posted on 2025-07-02
2479 The Association Between SLIT2 in Human Vitreous Humor and Plasma and Neurocognitive Test Scores
Shoushtari, S. I.; Liaw, E.; Alluri, S.; Sheikh, Z.; Kumar, S.; Huynh, C.; Schmidt, I. M.; Ness, S.; Chen, X.; Siegel, N. H.; Waikar, S. S.; Stein, T. D.; Lu, W.; Subramanian, M. L.
10.1101/2025.05.03.652072 — neuroscience — Posted on 2025-07-02
2480 Learning Place Cells and Remapping by Decoding the Cognitive Map
Pettersen, M. B.; Schoyen, V. S.; Malthe-Sorenssen, A.; Lepperod, M. E.
10.1101/2024.03.14.585049 — neuroscience — Posted on 2025-07-02
2482 Light-directed evolution of dynamic, multi-state, and computational protein functionalities
Gligorovski, V.; Labagnara, M.; Scutteri, L.; Blackholm, M.; Moglich, A.; Mansouri, N.; Rahi, S. J.
10.1101/2024.02.28.582517 — synthetic biology — Posted on 2025-07-02
2483 Cell-type-specific execution of effector-triggered immunity
Chhillar, H.; Jo, L.; Redkar, A.; Kajala, K.; Jones, J. D.; Ding, P.
10.1101/2025.06.28.662111 — plant biology — Posted on 2025-07-02
2484 Medicago truncatula CORYNE modulates inflorescence meristem branching, nutrient signaling, and arbuscular mycorrhizal symbiosis
Orosz, J.; Lin, E. X.; Torres Ascurra, Y. C.; Kappes, M.; Lindsay, P. L.; Bashyal, S.; Everett, H.; Gautam, C. K.; Jackson, D.; Mueller, L. M.
10.1101/2024.09.20.614181 — plant biology — Posted on 2025-07-02
2486 Global analysis of membrane protein S-acylation in the model plant Arabidopsis thaliana
Zhou, L.; Su, L.; Zhou, M.; Gritsenko, M. A.; Wan, J.; Ma, Y.; Zhao, Y.; Pasa-Tolic, L.; Xu, D.; Stacey, G.
10.1101/2025.07.01.658617 — plant biology — Posted on 2025-07-02
2489 Blood pressure variability compromises vascular function in middle-aged mice
Mendiola, P. J.; O'Herron, P.; Xie, K.; Brands, M. W.; Bush, W.; Patterson, R. E.; DiStefano, V.; Filosa, J.
10.1101/2024.10.21.619509 — physiology — Posted on 2025-07-02
2491 Sideroflexins enable mitochondrial transport of polar neutral amino acids
Block, S.; Chi, F.; Rosen, P. C.; Pineda, S. S.; Darnell, A. M.; Abbott, K. L.; Pena, I. A.; Heiman, M.; Yilmaz, O. H.; Kory, N.; Vander Heiden, M. G.
10.1101/2025.06.18.660357 — biochemistry — Posted on 2025-07-02
2492 Avoidance of hydrogen sulfide is modulated by external and internal states in C. elegans
Pu, L.; Zhao, L.; Wang, J.; Deleuze, C.; Nilsson, L.; Henriksson, J.; Laurent, P.; Chen, C.
10.1101/2023.10.09.561535 — animal behavior and cognition — Posted on 2025-07-02
2493 Opposing roles for iron transport systems in gallium tolerance in extraintestinal pathogenic Escherichia coli
Parveen, N.; Durrant, S.; Olson, M. A.; Shakespear, E. P.; Jones, T.; Wilson, E.; Erickson, D. L.
10.1101/2025.07.01.662525 — microbiology — Posted on 2025-07-01
2497 Monitoring tropical forests with light drones: ensuring spatial and temporal consistency in stereophotogrammetric products
BARBIER, N.; Ploton, P.; Tulet, H.; Viennois, G.; Leblanc, H.; Burban, B.; Rejou-Mechain, M.; Verley, P.; Ball, J. G.; Feurer, D.; Vincent, G.
10.1101/2025.06.27.661894 — ecology — Posted on 2025-07-01
2500 Microbially-competent skin organotypics reveal dysregulated AhR signalling in microbial dysbiosis
McPolin-Hall, E. P.; Stephen, A. S.; Pardieu, C.; Allaker, R. P.; Bhogal, R. K.; Pople, J. E.; Philpott, M. P.; Hannen, R. F.
10.1101/2025.07.01.662505 — microbiology — Posted on 2025-07-01
2501 Subtle variations in a client protein determine bacterial Hsp90 dependence
Corteggiani, M.; Chaouche, A. A.; Bahun, M.; Honore, F. A.; Byrne, D.; Dementin, S.; Rebeaud, M. E.; GENEST, O.
10.1101/2025.07.01.662558 — microbiology — Posted on 2025-07-01
2502 HIF isoforms contribute distinctly during human NK cell activation
De Waele, J.; Verhezen, T.; Lau, H. W.; Melis, J.; Brants, L.; de Beukelaar, J.; Gevaerts, C.; Van Audenaerde, J.; Lardon, F.; Wouters, A.; Smits, E.
10.1101/2025.06.27.661904 — immunology — Posted on 2025-07-01
2503 AdSI-MIMO: Adaptive stain imputation with multi-input and multi-output learning for multiplex immunofluorescence imaging
Li, X.; Rana, P.; Gide, T. N.; Adegoke, N. A.; Mao, Y.; Berkovsky, S.; Coiera, E.; Wilmott, J. S.; Liu, S.
10.1101/2025.06.27.661891 — bioinformatics — Posted on 2025-07-01
2505 Towards the Development of Isoenergetic Peptide Nucleic Acid Based Probes Targeting Double-Stranded RNAs Through Enhancing Sequence-Specific Stacking Interactions
Lu, R.; Xi, K.; Lin, R.; Krishna, M. S.; Chen, Y.; Zhan, X.; zeng, h.; Li, X.; Fan, S.; Zhou, H.; Wu, W.; Lian, Y.; Dai, Y.; Zhu, L.; Li, G.; Chen, G.
10.1101/2025.06.28.662161 — biochemistry — Posted on 2025-07-01
2506 Ser500 phosphorylation acts as a conformational switch to prime eEF-2K for activation
Bohanon, A. L.; Browning, L. S.; Sammons, R. M.; Piserchio, A.; Tavares, C. D. J.; Cho, E. J.; Ghose, R.; DALBY, K. N.
10.1101/2025.06.30.662482 — biochemistry — Posted on 2025-07-01
2508 Temperature and predation alter metabolic scaling without changing size-based structure community in freshwater macroinvertebrates
Gjoni, V.; Glazier, D.; Pomeranz, J.; Junker, J.; Smith, A.; Woelber, J.; Reynolds, S.; Welch, T.; Wesner, J.
10.1101/2025.06.27.661898 — ecology — Posted on 2025-07-01
2510 Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
LaVigne, C. A.; Han, J.; Zhang, H.; Cho, S.; Kim, M.; Sethia, K.; Evers, B. M.; Acharya, A.; Chang, T.-C.; Mendell, J. T.
10.1101/2025.06.30.662380 — molecular biology — Posted on 2025-07-01
2511 Structural and functional characterization of the antigenicity of influenza A virus hemagglutinin subtype H15
Bhavsar, D.; Leon, A. N.; Hsu, W.-L.; Puente-Massaguer, E.; Ferguson, J.; Han, J.; Wilson, P.; Ward, A.; Krammer, F.
10.1101/2025.07.01.662631 — microbiology — Posted on 2025-07-01
2514 Bacterial Hsp90 promotes virulence factor production through maintenance of NRPS megaenzymes
Fratacci, A.; Chaouche, A. A.; Corteggiani, M.; Honore, F. A.; Berbar, M. K.; Bossuet-Greif, N.; Dementin, S.; Bleves, S.; Belghazi, M.; Lebrun, R.; Nougayrede, J.-P.; Oswald, E.; Ize, B.; Genest, O.
10.1101/2025.07.01.662645 — microbiology — Posted on 2025-07-01
2518 Continuous Directed Evolution of a Plant Histidinol Dehydrogenase to Extend Lifespan
Oliveira-Filho, E. R.; Gayen, A. K.; Leong, B. J.; Belt, K.; Millar, H.; Hanson, A. D.
10.1101/2025.07.01.662441 — synthetic biology — Posted on 2025-07-01
2519 Sweet taste receptor regulates proliferation and glucose uptake in glioblastoma cells
Costa, A. R.; Duarte, A. C.; Jorge, A. C.; Goncalves, I.; Lucas, C.; Matos, I. R.; Santos, C. R. A.
10.1101/2025.06.27.661813 — cancer biology — Posted on 2025-07-01
2523 Estimating anisotropy of single cells using a compliant biaxial stretcher
Marwah, H.; Bhatt, H.; Fartyal, N. S.; Nautiyal, R.; Veer, S.; Pullarkat, P. A.; Balakrishnan, S.
10.1101/2025.06.27.661720 — bioengineering — Posted on 2025-07-01
2527 Back-projection improves inference from sparsely sampled genomic surveillance data
Finney, E. E.; Lee, B.; Ahmed, S. F.; Sohail, M. S.; Quadeer, A. A.; McKay, M. R.; Barton, J. P.
10.1101/2025.06.29.662219 — evolutionary biology — Posted on 2025-07-01
2531 Emergence of zoonotic and multi-drug resistant Streptococcus suis
Brizuela, J.; Murray, G. G. R.; Boueroy, P.; Balmer, A. J.; Wongsurawat, T.; Jenjaroenpun, P.; Chopjitt, P.; Hatrongjit, R.; Weinert, L. A.; Kerdsin, A.; Schultsz, C.
10.1101/2025.06.30.662319 — microbiology — Posted on 2025-07-01
2532 Katydids Shift to Higher-Stability Gaits When Climbing Inclined Substrates
Riiska, C. A.; Harrison, J. S.; Thompson, R. D.; Nina, J. Q.; Gallice, G. R.; Rieser, J. M.; Bhamla, S.
10.1101/2025.04.04.647231 — animal behavior and cognition — Posted on 2025-07-01
2533 Mapping the GDF15 Arm of the Integrated Stress Response in Human Cells and Tissues
Smith, J. L. M.; Tanner, K.; Devine, J.; Monzel, A. S.; Batjargal, T.; Wilson, M. Z.; Cohen, A. A.; Picard, M.
10.1101/2025.01.31.635929 — cell biology — Posted on 2025-07-01
2535 Disruption of the spinal cord-gut axis alters gut microbial dynamics and carbohydrate cross-feeding
Mohssen, M.; Zayed, A. A.; Kigerl, K.; Du, J.; Smith, G. J.; Schwab, J. M.; Sullivan, M. B.; Popovich, P. G.
10.1101/2025.05.27.656368 — microbiology — Posted on 2025-07-01
2536 Phylogenomic analysis of the collagen-like BclA proteins in Clostridioides difficile
Cid-Rojas, F.; Guerrero-Araya, E.; Brito-Silva, C.; Pizarro-Guajardo, M.; Rodriguez-Sanchez, C.; Paredes-Sabja, D.
10.1101/2025.06.24.661383 — microbiology — Posted on 2025-07-01
2537 Nonsense-mediated decay controls a negative feedback loop in innate immune sensing
Boudreault, S.; Rivera-Lopez, Y.; Ferretti, M. B.; Bonner, J.; Jacobs, B.; Lynch, K. W.
10.1101/2025.05.09.652687 — immunology — Posted on 2025-07-01
2538 Foveated metamers of the early visual system
Broderick, W. F.; Rufo, G.; Winawer, J.; Simoncelli, E.
10.1101/2023.05.18.541306 — neuroscience — Posted on 2025-07-01
2540 Predicting Brain Volumes from Anthropometric and Demographic Features: Insights from UK Biobank Neuroimaging Data
Nazarzadeh, K.; Eickhoff, S. B.; Antonopoulos, G.; Hensel, L.; Tscherpel, C.; Komeyer, V.; Raimondo, F.; Grefkes, C.; Patil, K. R.
10.1101/2025.06.22.660902 — neuroscience — Posted on 2025-07-01
2542 A canonical chloroplast unfolded protein response triggered by misfolded polypeptides
Cantoia, A.; Bertero, F.; Berrocal, R.; Ceccarelli, E. A.; Blanco, N. E.; Rosano, G. L.
10.1101/2025.06.11.659047 — plant biology — Posted on 2025-07-01
2543 Spatiotemporal mapping of the contractile and adhesive forces sculpting early C. elegans embryos
Yamamoto, K.; Ichbiah, S.; Perez, M.; Borrego-Pinto, J.; Delbary, F.; Goehring, N.; Turlier, H.; Charras, G.
10.1101/2023.03.07.531437 — biophysics — Posted on 2025-07-01
2548 Snapshot of in-cell protein contact sites reveals new host factors and hijacking of paraspeckles during influenza A virus infection
Kotova, I.; Muehlberg, L.; Gilep, K.; Yu, D.; Ziemianowicz, D.; Stanelle-Bertram, S.; Beck, S.; Baeg, K.; Duss, O.; Gabriel, G.; Liu, F.; Bogdanow, B.; Kosinski, J.
10.1101/2025.03.09.642134 — microbiology — Posted on 2025-07-01
2550 Spontaneous Dynamics Predict the Effects of Targeted Intervention in Hippocampal Neuronal Cultures
Tentori, E.; Kastellakis, G.; Maschietto, M.; Leparulo, A.; Poirazi, P.; Mazzucato, L.; Allegra, M.; Vassanelli, S.
10.1101/2025.04.29.651327 — neuroscience — Posted on 2025-07-01
2551 Single neurons act as a memory buffer for space
Saber Marouf, B.; Reboreda, A.; Theissen, F.; Kaushik, R.; Sauvage, M.; Dityatev, A.; Yoshida, M.
10.1101/2025.06.27.661493 — neuroscience — Posted on 2025-07-01
2552 Paired and solitary ionocytes in the zebrafish olfactory epithelium
Peloggia, J.; Cheung, K. Y.; Petkova, M.; Schalek, R.; Boulanger-Weill, J.; Wu, Y.; Wang, S.; van Hateren, N. J.; Januszewski, M.; Jain, V.; Lichtman, J. W.; Engert, F.; Piotrowski, T.; Whitfield, T. T.; Jesuthasan, S.
10.1101/2024.11.08.620918 — neuroscience — Posted on 2025-07-01
2553 Using an Ordinary Differential Equation model to separate Rest and Task signals in fMRI
Kashyap, A.; Geenjaar, E. P. T.; Bey, P.; Dhindsa, J.; Glomb, K.; Plis, S.; Keilholz, S.; Ritter, P.
10.1101/2023.10.23.563564 — neuroscience — Posted on 2025-07-01
2555 Spatial μProBe: a correlative multimodal imaging approach for spatial profiling of biological micro-environments
C. Marques, F.; Mathavan, N.; Ohs, N.; Goenczoel, C.; J. Kendall, J.; Singh, A.; Yilmaz, D.; Günther, D.; Kuhn, G. A.; A. Schulte, F.; Wehrle, E.; Müller, R.
10.1101/2025.04.23.650252 — systems biology — Posted on 2025-07-01
2556 Microneedle-based precision payload delivery in plants
Li, M.; Poonam, A. D.; Singh, D.; Whitfield, A. E.; Wei, Q.
10.1101/2025.06.04.657704 — plant biology — Posted on 2025-07-01
2557 CD300e is a driver of the immunosuppressive tumor microenvironment and colorectal cancer progression via macrophage reprogramming
Barizza, A.; Vassallo, S.; Masatti, L.; Laffranchi, M.; Giacometti, S.; Lonardi, S.; Bugatti, M.; Coletta, S.; Pizzini, S.; Vermi, W.; Fassan, M.; Spolverato, G.; Sozzani, S.; Calura, E.; Codolo, G.
10.1101/2024.09.01.610700 — cancer biology — Posted on 2025-07-01
2558 Structure and iron-transporting mechanism of brain organic cation transporter 1
Chen, J.; Zhang, S.; Wei, W.; Teng, L.; Tao, L.; Gao, K.; Li, B.; Edwards, A.; Fan, H.; Liu, X.; Chen, L.
10.1101/2025.06.28.662014 — biophysics — Posted on 2025-07-01
2561 Nanopore- and AI-empowered microbial viability inference
Uerel, H.; Benassou, S.; Marti, H.; Reska, T.; Sauerborn, E.; Pinheiro Alves De Souza, Y.; Perlas, A.; Rayo, E.; Biggel, M.; Kesselheim, S.; Borel, N.; Martin, E. J.; Venegas, C. B.; Schloter, M.; Schroeder, K.; Mittelstrass, J.; Prospero, S.; Ferguson, J. M.; Urban, L.
10.1101/2024.06.10.598221 — bioinformatics — Posted on 2025-07-01
2562 Synchrotron Tomography-Based Inversion Pipeline for Estimating Elastic Properties of Rat Vertebral Endplate Finite Element Models
Chen, J.; Parmenter, A. L.; Sharma, A.; Newham, E.; Bele, E.; Marussi, S.; Pitsillides, A. A.; Terrill, N. J.; Mitchell, C.; Gupta, H. S.; Lee, P. D.
10.1101/2024.09.03.610954 — bioengineering — Posted on 2025-07-01
2563 Single-Cell Protein Interactomes by the Proximity Network Assay
Karlsson, F.; Simonetti, M.; Galonska, C.; Karlsson, M. J.; van Ooijen, H.; Kallas, T.; Thiagarajan, D.; Schweitzer, M.; Larsson, L.; van Hoef, V.; Tajvar, P.; Dahlberg, J.; De Temmerman, F.; Leijonancker, L.; Trombin, V.; Geny, S.; Forlin, R.; Negrini, E.; Petkov, S.; Franzen, L.; Bunz, J.; Moge, C.; Everberg, H.; Brodin, P.; Martinez Barrio, A.; Fredriksson, S.
10.1101/2025.06.19.660329 — bioengineering — Posted on 2025-07-01
2564 Climate and predation drive variation of diel activity patterns in chacma baboons (Papio ursinus) across southern Africa
Dzingwena, L.; Thel, L.; Choisy, M.; Garbett, R.; Wilkinson, A.; Venter, J.; Fritz, H.; Huchard, E.; Prugnolle, F.; Rougeron, V.
10.1101/2024.11.05.622068 — animal behavior and cognition — Posted on 2025-07-01
2565 Nanopore-based analysis unravels the genetic landscape and phylogenetic relationships of human-infecting Trichuris incognita and Trichuris trichiura in Cote d'Ivoire, Uganda, Tanzania, and Laos
Rahman, N.; Bär, M. A.; Dommann, J.; Hürlimann, E.; Coulibaly, J. T.; Ali, S.; Sayasone, S.; Beinamaryo, P.; Keiser, J.; Schneeberger, P. H. H.
10.1101/2024.07.31.605962 — genomics — Posted on 2025-07-01
2566 A high-quality reference genome for the Ural Owl (Strix uralensis) enables investigations of cell cultures as a genomic resource for endangered species
Chrysostomakis, I.; Mozer, A.; Bruno Di-Nizo, C.; Fischer, D.; Sargheini, N.; von der Mark, L.; Huettel, B.; Astrin, J. J.; Toepfer, T.; Boehne, A.
10.1101/2025.01.22.633903 — genomics — Posted on 2025-07-01
2568 Long term trend and short-term dynamics of a willow grouse population
Willebrand, T.; Hornell-Willebrand, M.; Brittas, R.; Kleiven, E.
10.1101/2023.05.03.539219 — ecology — Posted on 2025-07-01
2569 Tiger diet in Ranthambore Tiger Reserve: how do metabarcoding and mechanical sorting compare?
Mishrikotkar, S. K.; Yadav, N.; Harihar, A.; Goswami, V. R.; Ramakrishnan, U.; Ghosh-Harihar, M.
10.1101/2025.06.18.660266 — ecology — Posted on 2025-07-01
2570 RAD18 Methylation by the Methyltransferase SETD6 Attenuates DNA Breaks
Weil, L. E.; Feldman, M.; Duine, J. V.; Qiu, J.; LaBaer, J.; Levy, D.
10.1101/2025.06.27.662082 — molecular biology — Posted on 2025-07-01
2572 FCRLs and atypical transcriptional pattern in tumor infiltrating B cells from lung and renal cancer
Bryushkova, E. A.; Shchoka, E. V.; Lukyanov, D. K.; Gikalo, M. B.; Mushenkova, N.; Laktionov, K. K.; Kazakov, A. M.; Khalmurzaev, O. A.; Matveev, V. B.; Chudakov, D. M.; Serebrovskaya, E. O.
10.1101/2024.11.29.626090 — immunology — Posted on 2025-07-01
2573 Alpha and Beta Oscillations Mediate the Effect of Motivation on Neural Coding of Cognitive Flexibility
Delgado, J. M. C.; Ison, M. J.; Muhle-Karbe, P. S.; Stokes, M. G.; Hall-McMaster, S.; Myers, N. E.
10.1101/2025.03.11.642697 — neuroscience — Posted on 2025-07-01
2575 Common Neural Choice Signals reflect Accumulated Evidence, not Confidence
Desender, K.; Smet, A.; Erdil, D.; Gunay, E. M.; Visser, Y. F.; Le Denmat, P.; Van Marcke, H.
10.1101/2025.02.13.638046 — neuroscience — Posted on 2025-07-01
2577 GRASP: a modular toolkit for synthetic pentatricopeptide repeat RNA-binding proteins
Dennis, M. L.; Low, S. Y.; Viljoen, A.; Pullakhandam, A.; Colas des Francs-Small, C.; Campbell-Clause, L.; Bond, C. S.; Small, I.; Kwok van der Giezen, F. M.
10.1101/2025.06.29.661641 — synthetic biology — Posted on 2025-07-01
2578 A TNL receptor mediates microbiome feedbacks in Arabidopsis
Janse van Rensburg, H.; Schandry, N.; Waelchli, J.; Stengele, K.; Cadot, S.; Adachi, H.; Jandrasits, K.; Becker, C.; Schlaeppi, K.
10.1101/2025.02.25.640125 — plant biology — Posted on 2025-07-01
2579 omnideconv: a unifying framework for using and benchmarking single-cell-informed deconvolution of bulk RNA-seq data
Dietrich, A.; Merotto, L.; Pelz, K.; Eder, B.; Zackl, C.; Reinisch, K.; Edenhofer, F.; Marini, F.; Sturm, G.; List, M.; Finotello, F.
10.1101/2024.06.10.598226 — bioinformatics — Posted on 2025-07-01
2581 Chromosomal-level genome of the Pinus massoniana 'Minlin WY36'
Sun, W.-H.; Zhang, F.; Zhao, X.; Li, Z.; Liu, K.-W.; Wu, S.; Guo, Y.; Hu, X.; Zeng, M.; Wang, L.; Zhou, C.-Y.; Chen, D.; Zheng, R.; Wu, X.; Peng, D.-H.; Ma, L.; Wang, Z.-W.; Lan, W.; Chen, H.; Zou, S.; Tsai, W.-C.; Van de Peer, Y.; Liu, Z.-J.; Lan, S.
10.1101/2025.06.23.660646 — genomics — Posted on 2025-07-01
2586 Niche exclusion of a lung pathogen in mice with designed probiotic communities
Hern, K. E.; Phillips, A. M. E.; Mageeney, C. M.; Williams, K. P.; Sinha, A.; Carlson, H. K.; Poorey, K.; Collette, N. M.; Branda, S. S.; Arkin, A. P.
10.1101/2024.02.02.578711 — microbiology — Posted on 2025-07-01
2587 Thienopyrimidine amide analogs target MmpL3 in Mycobacterium tuberculosis
Baldin, V. P.; Harding, C. L.; Quach, D.; Sugie, J.; Pogliano, J.; Parish, T.
10.1101/2025.06.26.661674 — microbiology — Posted on 2025-07-01
2589 Yellow Fever Virus Interactomes Reveal Common and Divergent Strategies of Replication and Evolution for Mosquito-borne Flaviviruses
Kenaston, M. W.; Cherkashchenko, L.; Skawinski, C. L. S.; Fishburn, A. T.; Peddamallu, V.; Florio, C. J.; Robertson, A. E.; Bhattacharya, T.; Young, J. M.; Malik, H. S.; Shah, P. S.
10.1101/2025.06.14.659623 — systems biology — Posted on 2025-07-01
2590 Exact-match search with functional variant prediction enables automated DNA screening
Gretton, D.; Wang, B.; Edison, R.; Foner, L.; Berlips, J.; Vogel, T.; Kysel, M.; Chen, W.; Sage-Ling, F.; Van Hauwe, L.; Wooster, S.; Cozzarini, H.; Weinstein-Raun, B.; DeBenedictis, E. A.; Liu, A. B.; Chory, E.; Cui, H.; Li, X.; Dong, J.; Fabrega, A.; Dennison, C.; Don, O.; Ye, C. T.; Uberoy, K.; Rivest, R. L.; Gao, M.; Yu, Y.; Baum, C.; Damgard, I.; Yao, A. C.; Esvelt, K. M.
10.1101/2024.03.20.585782 — synthetic biology — Posted on 2025-07-01
2592 Inferring cell dynamics in stress-induced neuroblastoma cell cultures
Hafiichuk, K.; Hamis, S.; Karlsson, J.; Gisselsson, D.; Chattopadhyay, S.
10.1101/2025.03.17.643601 — cancer biology — Posted on 2025-07-01
2593 Single-cell morphodynamical trajectories enable prediction of gene expression accompanying cell state change
Copperman, J.; McLean, I. C.; Gross, S. M.; Singh, J.; Murthy, V.; Chang, Y. H.; Davies, A. E.; Zuckerman, D. M.; Heiser, L. M.
10.1101/2024.01.18.576248 — cell biology — Posted on 2025-07-01
2595 The gut microbiome shapes pharmacology and treatment outcomes for a key anti-inflammatory therapy
Villa Soto, V. S.; Degraeve, A. L.; Heath, C. M.; Orellana, D. A.; Reilly, E. R.; Mukherjee, M.; Brockert, J. G.; Dumlao, D. S.; Blank, R. B.; Perlmutter, N.; Yu, S.; Ashouri, J.; Scher, J. U.; Patterson, A. D.; Turnbaugh, P. J.; Nayak, R. R.; Mukherjee, M. F.
10.1101/2025.06.26.661733 — pharmacology and toxicology — Posted on 2025-07-01
2596 Computed Tomography-Derived Elastic Modulus as a Noninvasive Marker of Aortic Wall Integrity: Correlation with Histopathology in the Ascending Aorta
Yamana, F.; Shimamura, K.; Kawamura, T.; Shirakawa, T.; Yokota, J.; Kido, K.; Sakaniwa, R.; Saito, S.; Yamashita, K.; Harada, A.; Watanabe, Y.; Sakakibara, S.; Yoshioka, D.; Morii, E.; MIYAGAWA, S.
10.1101/2025.06.27.662075 — pathology — Posted on 2025-07-01
2597 Early adipose tissue wasting in a novel preclinical model of human lung cancer cachexia
Snoke, D. B.; van der Velden, J. L.; Bellefleur, E. R.; Dearborn, J. S.; Lenahan, S. M.; Beal, A. E.; Aboushousha, R.; Heininger, S. C. J.; Ather, J. L.; Mank, M. M.; Sarausky, H.; Stephenson, D.; Reisz, J. A.; D'Alessandro, A.; Majumdar, D.; Ahern, T. P.; Sandler, K. L.; Landman, B. A.; Janssen-Heininger, Y. M. W.; Poynter, M. E.; Seward, D. J.; Toth, M. J.
10.1101/2024.09.27.615385 — cancer biology — Posted on 2025-07-01
2598 KDM5 demethylases suppress R-loop-mediated viral mimicry and DNA damage in breast cancer cells
Lau, L.; Henderson, K.; Turkoz, A.; Linker, S.; Schlessinger, D.; Townsley, B.; Egan, B.; Ragunathan, S.; Rollins, R.; Bi, X.; Chen, Z. J.; Brodsky, O.; Restaino, C.; Murali, G.; Jensen-Pergakes, K.; Maaarstig, A.; Kermi, C.; Moore, P.; Classon, M.
10.1101/2025.02.26.640279 — cancer biology — Posted on 2025-07-01
2602 Ovarian germline stem cell dedifferentiation is cytoneme-dependent
Sutcliffe, C.; Nandy, N.; Revici, R.; Johnson, H.; Habib, S. J.; Ashe, H. L.; Wilcockson, S. G.
10.1101/2024.11.19.624350 — developmental biology — Posted on 2025-07-01
2604 Structure and function of a cross-neutralizing influenza neuraminidase antibody that accommodates recent N2 NA Asn245 glycosylation
Zhu, X.; Khalil, A. M.; Piepenbrink, M. S.; Yu, W.; Ma, Y.; Martinez-Sobrido, L.; Wilson, I. A.; Kobie, J. J.
10.1101/2025.06.30.662356 — immunology — Posted on 2025-07-01
2605 Influenza A Virus infection is associated with TDP-43 pathology and neuronal damage in the brain
Jeon, M.-T.; Kim, D.-H.; Cogill, S. A.; Kim, K.; Park, I. Y.; Kim, J.-H.; Nam, M.; Kim, D.-G.; Choi, I.-S.
10.1101/2025.06.30.662477 — neuroscience — Posted on 2025-07-01
2606 Neural xenografts contribute to long-term recovery in stroke via molecular graft-host crosstalk
Weber, R. Z.; Achon Buil, B.; Rentsch, N. H.; Perron, P.; Halliday, S.; Bosworth, A.; Zhang, M.; Kisler, K.; Bodenmann, C.; Zurcher, K. J.; Uhr, D.; Meier, D.; Peter, S. L.; Generali, M.; Lin, S.; Ruegg, M. A.; Nitsch, R. M.; Tackenberg, C.; Rust, R.
10.1101/2024.04.03.588020 — neuroscience — Posted on 2025-07-01
2611 Transcriptional response to Phytophthora root rot in raspberry identifies RiABP19, a Germin-like protein (GLP) gene with a putative role in resistance
Osama, R.; Ogilvie, C. E.; Fisher, S. R.; Welsh, L.; Fuller, J.; Smith, K.; Bezanger, A.; Milne, L.; McLellan, H.; Simpson, C. G.; Gilroy, E. M.; Grant, M. R.
10.1101/2025.07.01.662284 — plant biology — Posted on 2025-07-01
2614 Polystyrene and polyethylene terephthalate nanoplastics differentially impact mouse ovarian follicle function
Alahmadi, H.; Nadeem, M.; Pujols, A. M.; Reynolds, R.; Islam, M. S.; Gupta, I.; Potts, C.; Harbolic, A.; Lafontant, G.; Mitra, S.; Warner, G. R.
10.1101/2025.06.27.662011 — pharmacology and toxicology — Posted on 2025-07-01
2616 Machine learning enables de novo multi-epitope design of plasmodium falciparum circumsporozoite protein to target trimeric L9 antibody
Nelson, J. A. D.; Garfinkle, S. E.; Lin, Z. J.; Park, J.; Kim, A. J.; Bayruns, K.; McCanna, M. E.; Konrath, K. M.; Agostino, C. J.; Kulp, D. W.; John, A. R. O.; Pallesen, J.
10.1101/2025.06.29.662177 — biophysics — Posted on 2025-07-01
2617 Cryo-EM of cardiac AL-224L amyloid reveals shared features in {lambda}6 light chain fibril folds
Hicks, C. W.; Prokaeva, T.; Spencer, B.; Jayaraman, S.; Huda, N.; Wong, S.; Chen, H.; Sanchorawala, V.; Lavatelli, F.; Gursky, O.
10.1101/2025.06.25.661559 — biophysics — Posted on 2025-07-01
2618 β-arrestin recruitment facilitates a direct association with G proteins
Lee, C. Y.; Smith, J. S.; Kohlmann, T.; Meara, E. M.; Pham, U.; Kwarcinski, F.; Dates, A. N.; Choi, I.; Hilibrand, A. S.; Gillikin, A.; Blacklow, S. C.; Tall, G. G.; Kruse, A. C.; Rajagopal, S.
10.1101/2025.06.24.661366 — biochemistry — Posted on 2025-07-01
2621 Organization of the apical extracellular matrix during tubular organ formation
Woodward, J. L.; Matthew, J.; Joshi, R.; Vishwakarma, V.; Xiao, Y.; Chung, S.
10.1101/2024.11.20.624565 — developmental biology — Posted on 2025-07-01
2623 Side-by-side systematic characterization of novel FPs in budding yeast
Botman, D.; de Groot, D. H.; Wehrens, M.; van Rossum, K.; Yska, S.; van der Kieft, B.; Albert, V.; Minghetti, N.; Goedhart, J.; Teusink, B.
10.1101/2025.06.27.661975 — molecular biology — Posted on 2025-07-01
2625 A systematic protocol to identify 'clinical controls' for pediatric neuroimaging research from clinically acquired brain MRIs
Zimmerman, D.; Mandal, A. S.; Jung, B.; Buczek, M. J.; Schabdach, J. M.; Karandikar, S.; Kafader, E.; Mercedes, L.; Kohler, S.; Abdel-Qader, L.; Gur, R. E.; Roalf, D.; Satterthwaite, T. D.; Schmitt, J. E.; Williams, R.; Padmanabhan, V.; Seidlitz, J.; White, L. K.; Sotardi, S.; Vossough, A.; Alexander-Bloch, A.
10.1101/2025.06.25.661530 — neuroscience — Posted on 2025-07-01
2626 Biological Database Mining for LLM-Driven Alzheimer's Disease Drug Repurposing
Schmitt, R. A.; Buelau, K.; Martin, L.; Huettl, C. V. M.; Schirner, M.; Stefanovski, L.; Ritter, P.
10.1101/2024.12.04.626255 — neuroscience — Posted on 2025-07-01
2629 Cell-type-specific execution of effector-triggered immunity
Chhillar, H.; Jo, L.; Redkar, A.; Kajala, K.; Jones, J. D.; Ding, P.
10.1101/2025.06.28.662111 — plant biology — Posted on 2025-07-01
2632 Molecular mechanisms of 10-Butyl Ether Minocycline (BEM), a novel non-antibiotic tetracycline, as a potential treatment for inflammatory and neuroimmune-related disorders.
Shaik, A. A.; Panthagani, P.; Liu, X.; Navarro-Turk, S.; Garza, J.; Aguilera, M.; Sanchez, J.; Gupta, K.; Hamood, A.; Reid, T. W.; Blough, B.; Pauli, E.; Bailoo, J. D.; Bergeson, S. E.
10.1101/2025.06.23.661183 — pharmacology and toxicology — Posted on 2025-07-01
2635 Micron-scale protein transport along microtubules by kinesin-driven shepherding
Farhadi, L.; Fiorenza, S.; Wijeratne, S.; Nakos, K.; Yue, Y.; Pimm, M.; Keya, J. J.; Verhey, K.; Subramanian, R.; Betterton, M.
10.1101/2025.06.28.662138 — biophysics — Posted on 2025-07-01
2637 RNAGenesis: A Generalist Foundation Model for Functional RNA Therapeutics
Zhang, Z.; Jin, R.; Chao, L.; Xu, G.; Zhang, Y.; Zhou, G.; Yin, D.; Guo, Y.; Fu, Y.; Yang, Y.; Huang, K.; Wang, X.; Zhang, J.; Yang, Y.; Yang, Q.; Xu, Z.; E, W.; Zhou, R.; Zhang, X.; Wang, M.; Cong, L.
10.1101/2024.12.30.630826 — bioinformatics — Posted on 2025-07-01
2638 Generation, characterization and exploiting caprine herpesvirus 1 secreted glycoprotein D
Minesso, S.; Odigie, A. E.; Franceschi, V.; Taddei, S.; Madia, V.; Tempesta, M.; Donofrio, G.
10.1101/2025.06.30.662481 — microbiology — Posted on 2025-07-01
2639 Fusion of Complement Fragment C3d Enhances Germinal Center Responses to HIV-1 Envelope Glycoproteins
de Gast, M.; Hernandez-Perez, S.; Pradhan, A.; Kruijer, S.; Olijhoek, W.; Baken, I. J. L.; Matti, C.; Breeuwsma, M.; Tean, Z. S.; van Keizerswaard, W. J. C.; Zoomer, S.; Burger, J. A.; Caniels, T. G.; Sliepen, K.; Derking, R.; Thapa, M.; Grakoui, A.; Heesters, B. A.; Claireaux, M. A. F.; Sanders, R. W.; Tolar, P.; Kasturi, S. P.; van Gils, M. J.
10.1101/2025.06.28.661730 — immunology — Posted on 2025-07-01
2640 Growing Minds, Integrating Senses: Neural and Computational Insights into Age-related Changes in Audio-Visual and Tactile-Visual Learning in Children
Raduner, N.; Providoli, C.; Di Pietro, S.; Schneebeli, M.; Karipidis, I. I.; Casimiro, E.; Bedi, S.; von Rhein, M.; Raschle, N. M.; Ruff, C. C.; Brem, S.
10.1101/2025.03.04.639748 — neuroscience — Posted on 2025-07-01
2643 A Transcriptomic Atlas of Macauba Palm Reveals Organ-Specific Gene Expression and Stress-Related Pathways
de Carvalho, L. M.; Bazzo, B. R.; Shanley, C. C.; Colombo, C. A.; Pereira, G. A. G.; Carazzolle, M. F.
10.1101/2025.06.27.661789 — plant biology — Posted on 2025-07-01
2649 Floral innovation through modifications in stem cell peptide signaling.
Jones, D. S.; Selby, R.; Jimenez-Sandoval, P.; Willoughby, A. C.; Yaklich, E.; DiBattista, A. T.; Baczynski, J.; Wang, F.; Zhang, T.; Gurung, V.; Crook, A. D.; Roman, A.-O.; Moore-Pollard, E.; Schuld, R.; Mandel, J. R.; Elomaa, P.; Burke, J. M.; Santiago, J.; Nimchuk, Z. L.
10.1101/2025.06.27.661788 — plant biology — Posted on 2025-07-01
2651 Fabry-Perot Microscopy for Improved Contrast Enhancement and 3D Cellular Imaging
Pittrich, J.; von Koeller, G.; Dillitzer, C.; Sandner, D.; Emken, E.; Sistermanns, J.; Wolf, Z.; Schlegel, M.; Weirich, G.; Kienberger, R.; Hayden, O.; Iglev, H.
10.1101/2025.06.26.661870 — biophysics — Posted on 2025-07-01
2652 Ligand-dependent G protein dynamics underlying opioid signaling efficacy
Deutsch, J.; Hilger, D.; Janetzko, J.; Schroeder, C. M.; Chu, S.; Kobilka, B.; Shivnaraine, R. V.
10.1101/2025.06.30.662233 — biophysics — Posted on 2025-07-01
2653 De novo designed 3-helix bundle peptides and proteins with controlled topology and stability
Leng, X.; Albanese, K. I.; Golub, L. R.; Norman, A. A.; Clayden, J.; Woolfson, D. N.
10.1101/2025.06.30.662276 — biophysics — Posted on 2025-07-01
2654 Interaction of Wnt and SHH gradients synchronizes cell cycle exit and differentiation
Li, R.; Jiang, Y.; Platt, S.; Peterson, K. A.; Lam, H.; Van, S.; Lim, C. H.; Levinsohn, J.; Barber, E.-L.; Wang, D.; Taketo, M. M.; Kluger, Y.; Myung, P. S.
10.1101/2025.06.29.660399 — developmental biology — Posted on 2025-07-01
2655 Fluctuation structure predicts genome-wide perturbation outcomes
Kuznets-Speck, B.; Schwartz, L.; Sun, H.; Melzer, M. E.; Kumari, N.; Haley, B.; Prashnani, E.; Vaikuntanathan, S.; Goyal, Y.
10.1101/2025.06.27.661814 — systems biology — Posted on 2025-07-01
2656 High-throughput High Content Quantification of HIV-1 Viral Infectious Output
Brantly, A.; Lupone, T.; Oteju, O.; Matt, S. M.; Nickoloff-Bybel, E. A.; Runner, K.; Nonnemacher, M.; Gaskill, P. J.
10.1101/2025.06.28.662157 — microbiology — Posted on 2025-07-01
2657 Pathogenic fungus exploits the lateral root regulators to induce pluripotency in maize shoots
Khan, M.; Nagarajan, N.; Schneewolf, K.; Marcon, C.; Wang, D.; Hochholdinger, F.; Yu, P.; Djamei, A.
10.1101/2025.06.30.662278 — plant biology — Posted on 2025-07-01
2660 Single-cell-resolved calcium and organelle dynamics in resistosome-mediated cell death
Chen, Y.-F.; Lin, K.-Y.; Huang, C.-Y.; Hou, L.-Y.; Yuen, E. L. H.; Sun, W.-C. J.; Chiang, B.-J.; Chang, C.-W.; Wang, H.-Y.; Bozkurt, T. O.; Wu, C.-H.
10.1101/2025.06.27.662017 — plant biology — Posted on 2025-07-01
2661 Whole-genome sequencing in Galicia reveals male-biased pre-Islamic North African ancestry, subtle population structure, and micro-geographic patterns of disease risk
Pardo-Seco, J.; Camino-Mera, A.; Bello, X.; Gomez-Carballa, A.; Castelo-Martinez, L.; Martinez-Cadenas, C.; Martinon-Torres, F.; Salas, A.
10.1101/2025.06.27.662083 — genomics — Posted on 2025-07-01
2663 Genetically encoded mechano-sensors with versatile readouts and compact size
Ren, Y.; Yang, J.; Saito, T.; Glomb, O.; Kumar, A.; Mousavi, S. I.; Naughton, B.; de Fontnouvelle, C.; Fujita, B.; Schlieker, C.; Yogev, S.; Zhang, Y.; Berro, J.
10.1101/2025.01.16.633409 — cell biology — Posted on 2025-07-01