bioRxiv directory

Boyd, A. I.; Kafer, L. A.; F. Escapa, I.; Kambal, A.; Tariq, H.; Hilsenbeck, S. G.; Nguyen-Phuc, H.; Rajan, A.; Lensmire, J. M.; Patras, K. A.; Piedra, P. A.; Blutt, S. E.; Lemon, K. P.

10.1101/2024.09.25.614934 — microbiology — Posted on 2025-04-30

3 A bacterial regulatory uORF senses multiple classes of ribosome-targeting antibiotics

Baniulyte, G.; Wade, J.

10.1101/682021 — microbiology — Posted on 2025-04-30

4 On pathogenicity with varying microbial virulence and host resistance

Gupta, A.; Unckless, R.

10.1101/2024.10.02.616271 — immunology — Posted on 2025-04-30

5 How Bacterial Vesicles Trigger Hearing Loss: The Role of Pyroptosis in Cochlear Damage

Xu, T.; Zhang, J.; Zhao, H.; Nong, H.; Yang, Q.; Yuan, Y.; Zhao, J.; Zhang, X.; Li, Y.; Tun, Z. M. M.; Bekale, L.; Cao, Z.

10.1101/2025.04.28.650954 — immunology — Posted on 2025-04-30

6 Dendritic synaptic integration modes under in vivo-like states

Ceballos, C. C.; Pena, R. F.

10.1101/2024.11.18.624129 — neuroscience — Posted on 2025-04-30

7 Controlling the taxonomic composition of biological information storage in 16S ribosomal RNA

Gamas, K. R.; Seamons, T.; Dysart, M.; Fang, L.; Chappell, J.; Stadler, L.; Silberg, J.

10.1101/2025.04.29.651329 — synthetic biology — Posted on 2025-04-30

8 Actin Depolymerization Factors (ADFs) Moonlighting: Nuclear Immune Regulation by Interacting with WRKY Transcription Factors and Shaping the Transcriptome

Li, P.; Kelley, B.; Li, Z.; Procter, B.; Corrion, A.; Xie, X.; Sheick, R.; Lu, Y.-j.; Nomoto, M.; Wei, C.-i.; Tada, Y.; He, S.-Y.; Xiao, S.; Day, B.

10.1101/2025.04.29.651294 — plant biology — Posted on 2025-04-30

9 Comparative Analysis of the Effects of PSPH and PHGDH Inhibitors on Tumor Cell Proliferation

wang, y.; sha, l.

10.1101/2025.04.28.650903 — cancer biology — Posted on 2025-04-30

10 IsoBayes: a Bayesian approach for single-isoform proteomics inference

BOLLON, J.; SHORTREED, M. R.; JORDAN, B. T.; MILLER, R.; JEFFERY, E.; CAVALLI, A.; SMITH, L. M.; DEWEY, C.; SHEYNKMAN, G. M.; Tiberi, S.

10.1101/2024.06.10.598223 — bioinformatics — Posted on 2025-04-30

11 F.O.R.W.A.R.D: A Data-Driven Framework for Network-Based Target Prioritization in Drug Discovery

Sinha, S.; McLaren, E. G.; Mullick, M.; Penrose, H. M.; Tindle, C.; Singh, S.; Boland, B. S.; Ghosh, P.

10.1101/2024.07.16.602603 — bioinformatics — Posted on 2025-04-30

12 FlatProt: 2D visualization eases protein structure comparison

Olenyi, T.; Carl, C.; Senoner, T.; Koludarov, I.; Rost, B.

10.1101/2025.04.22.650077 — bioinformatics — Posted on 2025-04-30

13 Genetic variants linked to neurodevelopmental disorders within the β3-β4 loop of the TRIO PH2 domain release autoinhibition of GEF2 activity.

Carrizales, M. G.; Boulton, A.; Koleske, A. J.

10.1101/2025.04.14.648796 — biochemistry — Posted on 2025-04-30

14 Dynamic convergence of autism disorder risk genes across neurodevelopment

Fernandez Garcia, M.; Retallick-Townsley, K.; Balafkan, N.; Pruitt, A.; Davidson, E.; Dai, Y.; Fitzpatrick, S. E.; Huang, T.-C.; Kibowen, A.; Warrell, J.; Meng, R.; Chu, Z.; Sen, A.; Cohen, S.; Livoti, O.; Khan, S.; Becker, C.; Luiz Teles Silva, A.; Liu, J.; Dossou, G.; Cheung, J.; Ghorbani, S.; Deans, P. J. M.; DeCiucis, M.; Shen, H.; Gerstein, M.; Gao, H.; Wang, Z.; Huckins, L.; Hoffman, E.; Brennand, K.

10.1101/2024.08.23.609190 — genetics — Posted on 2025-04-30

15 Behavioral variation across multiple phases of intravenous cocaine self-administration among genetically diverse mouse populations

Dickson, P. E.; Datta, U.; Wilcox, T. D.; Auth, A. A.; Ball, R. L.; Dunn, M.; Fisher, H. S.; Klein, A.; Leonardo, M. R.; Roy, T. A.; Saul, M. C.; Bubier, J. A.; Gagnon, L. H.; Philip, V. M.; Tarantino, L. M.; Jentsch, J. D.; Chesler, E. J.

10.1101/2025.04.23.650259 — genetics — Posted on 2025-04-30

16 Core gene set of the species Saccharomyces cerevisiae

Dietrich, F. S.; Magwene, P. M.; McCusker, J. H.

10.1101/2023.09.07.545205 — genetics — Posted on 2025-04-30

17 Parallel evolution of X chromosome-specific SMC complexes in two nematode lineages

Aharonoff, A.; Kim, J.; Washington, A.; Ercan, S.

10.1101/2024.05.21.595224 — evolutionary biology — Posted on 2025-04-30

18 Cuticular collagens mediate cross-kingdom predator-prey interactions between nematodes and trapping fungi

Chang, H.-W.; Lin, H.-C.; Yang, C.-T.; Tay, R. J.; Chang, D.-M.; Tung, Y.-C.; Hsueh, Y.-P.

10.1101/2025.04.28.650945 — evolutionary biology — Posted on 2025-04-30

19 The major histocompatibility complex: a double-edged sword in fungal disease susceptibility

FU, M.; Eimes, J. A.

10.1101/2024.12.13.628321 — ecology — Posted on 2025-04-30

20 Chronic broadband noise increases the fitness of a laboratory-raised freshwater zooplankton

Prosnier, L.; Rojas, E.; Valero, O.; Medoc, V.

10.1101/2022.11.19.517212 — ecology — Posted on 2025-04-30

21 Temporal dynamics of gene expression during metamorphosis in two distant Drosophila species

Ozerova, A. M.; Kulikova, D. A.; Evgen'ev, M. B.; Gelfand, M. S.

10.1101/2024.06.17.599350 — developmental biology — Posted on 2025-04-30

22 Random UV Mutagenesis for the production of Chlorella vulgaris mutants with low chlorophyll content for the food industry

Ivanov, I. N.; Kopecky, J.; Sterbova, K.; Hrouzek, P.; Lukes, M.; Bisova, K.; Kurniawan, S. B.

10.1101/2025.04.28.651037 — cell biology — Posted on 2025-04-30

23 Close-Up of vesicular ER Exit Sites by Volume Electron Imaging using FIB-SEM

Nair, A.; Nair, A.; Stock, P.; Jain, A.; Somerville, E.; Sanyal, A.; Kirchhausen, T.

10.1101/2025.04.23.650353 — cell biology — Posted on 2025-04-30

24 Opposing Regulation of TNF Responses by IFN-γ and a PGE2-cAMP Axis that is Apparent in Rheumatoid and Immune Checkpoint Inhibitor-induced Arthritis IL-1β+ Macrophages

Sokhi, U. K.; Yuan, R.; Mishra, B.; Chinenov, Y.; Singaraju, A.; Chan, K. K.; Bass, A.; Bell, R. D.; Donlin, L.; Ivashkiv, L. B.

10.1101/2024.11.11.623039 — immunology — Posted on 2025-04-30

25 Diverse perceptual biases emerge from Hebbian plasticity in a recurrent neural network model

Schönsberg, F.; Giana, D.; Chopra, Y.; Diamond, M. E.; Goldt, S.

10.1101/2024.05.30.596641 — neuroscience — Posted on 2025-04-30

26 Exploring GPCR-mediated optogenetic modulation of seizure network in a pig model of Temporal Lobe Epilepsy

Chang, S.-y.; Bar-Or, K. L.; Mivalt, F.; Maltais, D.; Kfir, Y.; Kim, J.; Kim, I.; Hershko, M.; Daily, J.; Swissa, E.; Levi, O.; Yizhar, O.; Eldar, Y.; Worrell, G.

10.1101/2025.01.23.634545 — neuroscience — Posted on 2025-04-30

27 An enteric neuron-expressed variant ionotropic receptor detects ingested salts to regulate salt stress resistance

Yeon, J.; Chen, L.; Krishnan, N.; Bates, S.; Porwal, C.; Sengupta, P.

10.1101/2025.04.11.648259 — neuroscience — Posted on 2025-04-30

28 Large-scale infra-slow dynamics of extracellular potentials linked to synchronous states revealed by graphene neural probes

Garcia-Cortadella, R.; Cisneros-Fernandez, J.; Schwesig, G.; Shahidi, A.; Umurzakova, A.; Schaefer, N.; Aguilar, J.; Masvidal-Codina, E.; Del Corro, E.; Mohrlok, R.; Kurnoth, M.; Paetzold, J.; Jeschke, C.; Loeffler, H.; Meents, J.; Illa, X.; Serra-Graells, F.; Guimera-Brunet, A.; Garrido, J. A.; Sirota, A.

10.1101/2024.12.20.629545 — neuroscience — Posted on 2025-04-30

29 Partial Correlation as a Tool for Mapping Functional-Structural Correspondence in Human Brain Connectivity

Santucci, F.; Jimenez-Marin, A.; Gabrielli, A.; Bonifazi, P.; Ibanez-Berganza, M.; Gili, T.; Cortes, J. M.

10.1101/2024.10.16.618230 — neuroscience — Posted on 2025-04-30

30 Control of leaflet movement pattern by a novel PP2C phosphatase DLM1 in Medicago truncatula

Zhou, D.; Guo, S.; Yang, W.; Zhao, B.; Zhao, W.; Zhou, S.; Mao, Y.; Zhang, H.; Fang, Y.; He, L.; Yang, L.; Liu, C.; Chen, J.; Bai, Q.

10.1101/2025.04.28.650909 — plant biology — Posted on 2025-04-30

31 NCR13 peptide protects soybean against Cercospora sojina by multiple modes of action and additive interaction with chemical fungicides

Pokhrel, A.; Nath, V. S.; Godwin, J.; Kalunke, R.; TETORYA, M.; Czymmek, K. J.; Shah, D. M.

10.1101/2025.04.29.651315 — plant biology — Posted on 2025-04-30

32 The Building Blocks of Early Land Plants: Glycosyltransferases and Cell Wall Architecture in the model liverwort Marchantia polymorpha

Kang, H. S. F.; Tong, X.; Mariette, A.; Leong, M.; Beahan, C.; Flores-Sandoval, E.; Pedersen, G.; Rautengarten, C.; Bowman, J. L.; Ebert, B.; Bacic, A.; Doblin, M.; Persson, S.; Lampugnani, E. R.

10.1101/2025.04.30.651426 — plant biology — Posted on 2025-04-30

33 Molecular dynamics analyses of CLDN15 pore size and charge selectivity

McGuinness, S.; Li, P.; Li, Y.; Fuladi, S.; Konar, S.; Bafghi, S. S.; Sidahmed, M.; Li, Y.; Shen, L.; Khalili-Araghi, F.; Weber, C. R.

10.1101/2023.08.16.553400 — physiology — Posted on 2025-04-30

34 PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP

Wang, J.; Shi, Y.; Wang, Y.; Shen, Y.; Liu, H.; Sun, S.; Wang, Y.; Zhou, X.; Zhou, Y.; Zeng, X.; Li, J.; Chen, Q.

10.1101/2024.07.23.604769 — cancer biology — Posted on 2025-04-30

35 Prolonged Crowding Initiates Tumor Invasion with Mechanomemory by Pressure-Sensation of Membrane Domains

Zhao, X.; Tan, M.; Li, L.; Lin, X.; Li, Z.; Wang, X.; Song, B.; Guo, Z.; Chen, T.; Hou, S.; Fan, J.; Wang, S.; Zhang, Y.; Fan, Y.; Du, J.

10.1101/2024.07.28.605413 — cancer biology — Posted on 2025-04-30

36 Plasma exosomes from individuals with type 2 diabetes drive breast cancer aggression in patient-derived organoids

Ennis, C. S.; Seen, M.; Chen, A.; Kang, H.; Ilinski, A.; Mahdaviani, K.; Ko, N. Y.; Monti, S.; Denis, G. V.

10.1101/2024.09.13.612950 — cancer biology — Posted on 2025-04-30

37 Expanding Automated Multiconformer Ligand Modeling to Macrocycles and Fragments

Flowers, J.; Echols, N.; Correy, G.; Jaishankar, P.; Togo, T.; Renslo, A. R.; van den Bedem, H.; Fraser, J. S.; Wankowicz, S. A.

10.1101/2024.09.20.613996 — biophysics — Posted on 2025-04-30

38 Maximal Efficacy of Alternative Splicing is Ensured by Balanced Efficiency of U1 and U2AF

Hu, J.; Douek, D. C.

10.1101/2025.04.24.650448 — bioinformatics — Posted on 2025-04-30

39 MTBseq-nf: Enabling Scalable Tuberculosis Genomics "Big Data" Analysis through a User-Friendly Nextflow Wrapper for MTBseq pipeline

Sharma, A.; Marcon, D. J.; Loubser, J.; Batista Lima, K. V.; van der Spuy, G.; Costa Conceicao, E.

10.1101/2025.04.17.649337 — bioinformatics — Posted on 2025-04-30

40 Tumor-targeted hydroxyapatite nanoparticles for dual-mode diagnostic imaging and near-infrared light-triggered photothermal cancer therapy

Palanikumar, L.; Yasin, F. M.; Munkhjargal, I.; Boitet, M.; Ali, L.; Ali, M. S.; Straubinger, R.; Barrera, F. N.; Magzoub, M.

10.1101/2025.02.20.639217 — bioengineering — Posted on 2025-04-30

41 Genome-wide association study in European beech (Fagus sylvatica L.) for drought stress traits

Tost, M.; Grigoriadou-Zormpa, O.; Wilhelmi, S.; Targem, M. B.; Mueller, M.; Wildhagen, H.; Curtu, A. L.; Beissinger, T.; Gailing, O.

10.1101/2025.04.08.647712 — genetics — Posted on 2025-04-30

42 Large effect life-history genomic regions are associated with functional morphological traits in Atlantic salmon

Aykanat, T.; Debes, P. V.; Jansouz, S.; Gueguen, L.; House, A. H.; Ruokolainen, A.; Erkinaro, J.; Pritchard, V. L.; Primmer, C. R.; Bolstad, G. H.

10.1101/2024.12.05.627014 — ecology — Posted on 2025-04-30

43 Computationally Designed RNA Aptamers Enable Selective Detection of FUS Pathology in ALS

Zacco, E.; Gilodi, M.; Armaos, A.; Waldron, F.; Rupert, J.; Schneider, N.; Gregory, J.; Tartaglia, G. G.

10.1101/2025.04.30.651570 — biochemistry — Posted on 2025-04-30

44 Best practices for improving alignment and variant calling on human sex chromosomes

Oill, A. M. T.; Plaisier, S. B.; Phung, T. N.; Wilson, M. A.

10.1101/2025.04.29.651297 — genomics — Posted on 2025-04-30

45 Piwi and piRNAs repress transcription of aberrant rRNA genes containing retrotransposon fragments

Fefelova, E. A.; Shatskikh, A. S.; Mikhaleva, E. A.; Abramov, Y. A.; Lavrov, S. A.; Pirogov, S. A.; Poltorachenko, V. A.; Ilin, A. A.; Zamore, P. D.; Klenov, M. S.

10.1101/2025.04.30.651568 — molecular biology — Posted on 2025-04-30

46 PASTA: Versatile Tyramine-oligonucleotide Amplification for Multi-modal Spatial Biology

Michel, H. A.; McCallum, P.; Wu, W.; Lee, J. L.; Luo, S.; Chan, C. N.; Schaffenrath, J.; Yeo, Y. Y.; Yiu, S. P. T.; Wang, Y.; Parmelee, L.; Wang, H.; Burgess, M.; El Ahmar, N.; Zhang, Z. X.; Keane, C.; Lim, T.; Signoretti, S.; Del Rincon, S. V.; Zhao, B.; McIlwain, D. R.; Bai, Y.; Chen, F.; Jiang, S.

10.1101/2025.04.30.651463 — molecular biology — Posted on 2025-04-30

47 In-cell proximity target validation methods for heterobifunctional molecules with CRBN- or VHL-binder using AirID

Yamada, K.; Yamanaka, S.; Yamakoshi, H.; Kohyama, A.; Iwabuchi, Y.; Kosako, H.; Sawasaki, T.

10.1101/2025.04.29.651368 — molecular biology — Posted on 2025-04-30

48 High frequency body site translocation of nosocomial Pseudomonas aeruginosa

Fisher, L. W. S.; Thorpe, H. A.; Sassera, D.; Corander, J.; Bryant, J. M.

10.1101/2025.04.30.651244 — microbiology — Posted on 2025-04-30

49 Competition with Pseudomonas aeruginosa induces Staphylococcus aureus in an antibiotic-tolerant viable but non culturable state

Lapinska, U.; Chandran, G.; Tunstall, t.; Zborowsky, S.; Tolle, G.; Verderosa, A.; Garcia Castillo, M.; ONeill, P. A.; Farbos, A.; Jeffries, A. R.; Young, A. R.; Canton, R.; Caboni, P.; Blaskovich, M.; Warris, A.; Tsaneva-Atanasova, K.; Pagliara, S.

10.1101/2025.04.30.651255 — microbiology — Posted on 2025-04-30

50 Gut bacteria gatekeep host-specific colonization of a commensal fungus that boosts type 2 immunity

Han, G.; Yunker, R.; Hasan, M. H.; Bruce, A.; Baldaro, K.; Pacia, J.; Lockwood, O.; Miralles, D. M.; Jarjour, N. N.; Chellappa, K.; Vaishnava, S.; Beura, L. K.

10.1101/2025.04.30.651489 — microbiology — Posted on 2025-04-30

51 High-resolution phenotypic screen in zebrafish identifies novel regulators of CNS axon diameter growth

Eichel-Vogel, M. A.; Soong, D.; Sequeira, M. N.; Marshall-Phelps, K. L.; Bin, J. M.; Lyons, D. A.

10.1101/2025.04.29.651302 — neuroscience — Posted on 2025-04-30

52 Ivermectin binds to the allosteric site (site 2) and inhibits allosteric integrin activation by pro-inflammatory cytokines.

Takada, Y. K.; Takada, Y.

10.1101/2025.04.30.651550 — biochemistry — Posted on 2025-04-30

53 Design of an orally bioavailable small molecule that modulates the microtubule-associated protein tau's pre-mRNA splicing

Zhang, P.; Taghavi, A.; Abe, M.; Aikawa, H.; Akahori, Y.; Chen, J. L.; Tong, Y.; Baisden, J. T.; Cameron, M. D.; childs-disney, J. L.; Disney, M. D.

10.1101/2025.04.30.651234 — biochemistry — Posted on 2025-04-30

54 Reduced heparan sulfate levels in cerebrospinal fluid reflect brain neuron correction in Sanfilippo B mice

Le, S. Q.; Sorensen, A.; Sukupolvi, S.; Jewhurst, G.; Austin, G.; Doray, B.; Cooper, J. D.; Dickson, P.

10.1101/2025.04.30.651515 — biochemistry — Posted on 2025-04-30

55 RNase H1 levels dramatically affect mitochondrial genome maintenance with little impact on nuclear R-loops in murine B cells

Sakhuja, K.; Hartono, S. R.; Sanz, L. A.; Ijiri, E.; Darling, C.; Dye, L.; Iben, J. R.; Chon, H.; Cerritelli, S.; Crouch, R.; Chedin, F.

10.1101/2025.04.30.651504 — genomics — Posted on 2025-04-30

56 Dissecting regulatory syntax in human development with scalable multiomics and deep learning

Liu, B. B.; Jessa, S.; Kim, S. H.; Ng, Y. T.; Higashino, S. i.; Marinov, G. K.; Chen, D. C.; Parks, B. E.; Li, L.; Nguyen, T. C.; Wang, S. K.; Wang, A. T.; Tan, S. Y.; Kosicki, M.; Pennacchio, L. A.; Ben-David, E.; Pasca, A. M.; Kundaje, A.; Farh, K. K. H.; Greenleaf, W. J.

10.1101/2025.04.30.651381 — genomics — Posted on 2025-04-30

57 Exploring MicroRNA Strand Selection: Insights into Gene Regulation and Development

Meadows, D.; Hargis, H. L.; Ellis, A.; Mangone, M.

10.1101/2025.04.30.651563 — molecular biology — Posted on 2025-04-30

58 Molecular surface mimicry enables CRBN to target G3BP2 for degradation

Annunziato, S.; Quan, C.; Donckele, E. J.; Lamberto, I.; Bunker, R. D.; Zlotosch, M.; Schwander, L.; Murthy, A.; Wiedmer, L.; Staehly, C.; Matysik, M.; Gilberto, S.; Kapsitidou, D.; Wible, D.; De Donatis, G. M.; Trenh, P.; SriRamaratnam, R.; Strande, V.; Almeida, R.; Dolgikh, L.; DeMarco, B.; Tsai, J.; Sadok, A.; Zarayskiy, V.; Walter, M.; Tiedt, R.; Lumb, K. J.; Bonenfant, D.; Fasching, B.; Castle, J. C.; Townson, S. A.; Gainza, P.; Petzold, G.

10.1101/2025.04.30.651496 — molecular biology — Posted on 2025-04-30

59 Epigenetic motifs distinguishing endogenous from exogenous retroviral integrants

LaMere, S.; Xiong, H.; Wang, W.; LaMere, B.; Moshiri, N.

10.1101/2025.04.30.651506 — microbiology — Posted on 2025-04-30

60 Precise regulation of gene expression through transcriptional repression is essential for Plasmodium asexual blood stage development

Nishi, T.; kaneko, i.; Iwanaga, S.; Yuda, M.

10.1101/2025.04.30.651575 — microbiology — Posted on 2025-04-30

61 Resistance screening of uncharacterized Lupinus angustifolius accessions towards Fusarium oxysporum f. sp. lupini

Rayo, C.; Messner, E.; Tokina, K.; Svoboda, T.

10.1101/2025.04.30.651460 — microbiology — Posted on 2025-04-30

62 Cryo-EM structure of a type VI secretion system delivered membrane-depolarizing toxin involved in bacterial antagonism

Colautti, J.; Shatskiy, D.; Bates, E.; Bullen, N. P.; Belyy, A.; Whitney, J. C.

10.1101/2025.04.30.651342 — microbiology — Posted on 2025-04-30

63 Viral Infection Depends on Host's Metabolism

Marantos, A.; Sneppen, K.; Brown, S.; Mitarai, N.

10.1101/2025.04.30.651438 — microbiology — Posted on 2025-04-30

64 Murine model of antibiotic-associated S. aureus gastrointestinal infections (SAGII) and colonization

Niamba, M.; Yang, S.; Blank, L.; Watanabe, L.; Heredia, E.; Abel-Santos, E.

10.1101/2025.04.30.651547 — microbiology — Posted on 2025-04-30

65 Ciliated cells promote high infectious potential of influenza A virus through the efficient intracellular activation of hemagglutinin

Guo, Z.; Banas, V. S.; He, Y.; Weiland, E.; Xu, J.; Tan, Y.; Xiao, Z.; Brody, S. L.; Boon, A. C. M.; Janetka, J. W.; Vahey, M. D.

10.1101/2025.04.30.651529 — microbiology — Posted on 2025-04-30

66 Deriving microbial food web structure by maximizing entropy production over variable timescales

Vallino, J. J.; Ahern, O. M.; Huber, J. A.

10.1101/2025.04.30.651452 — microbiology — Posted on 2025-04-30

67 Imbalance in gut microbial interactions as a marker of health and disease

Lopez, R. C.; Bonachela, J.; Bello, M. G. D.; Manhart, M.; Levin, S.; Blaser, M.; Munoz, M. A.

10.1101/2025.04.30.651474 — microbiology — Posted on 2025-04-30

68 Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases

Burgener, S.; Milner, M. T.; Dey, S.; Morgan, P.; Blackmore, D. G.; Frampton, E.; Miller, G.; Durate de Oliveira, M.; Kenney, K. M.; Bajracharya, R.; Baumgartner, U.; Collins, T. T. J. C.; Xiong, Z.; Nguyen, Q.; Meikle, P.; Bodea, L.-G.; Clouston, A.; Boucher, D.; Goetz, J.; Murphy, A. J.; Kaye, P. J.; Schroder, K.

10.1101/2025.04.28.651119 — immunology — Posted on 2025-04-30

69 GBP1 drives lysosomal activity against cytosol-invading mycobacteria in macrophages

Aguirre-Garcia, M. A.; Portelli, S. M.; Varela, M.; Meijer, A.

10.1101/2025.04.28.650982 — immunology — Posted on 2025-04-30

70 Passive muscle forces in Drosophila are large but insufficient to support a flys weight

Wang, N.; Babski, H.; Perdomo, J. E.; McMahan, S. B.; Ramakrishnan, A.; Biswas, T.; Bhandawat, V.

10.1101/2025.04.29.651225 — neuroscience — Posted on 2025-04-30

71 RECUR: Identifying recurrent amino acid substitutions from multiple sequence alignments

Robbins, E. H.; Liu, Y.; Kelly, S.

10.1101/2025.04.29.651261 — bioinformatics — Posted on 2025-04-30

72 Kozak sequence libraries for characterizing transgenes across expression levels

Shukla, N.; Kamath, N. D.; Snell, J. C.; Bruchez, A. M.; Matreyek, K. A.

10.1101/2025.04.28.651141 — genetics — Posted on 2025-04-30

73 A CARF-HAD phosphatase effector provides immunity during the type III-A CRISPR-Cas response

Stella, G.; Ye, L.; Brady, S. F.; Marraffini, L. A.

10.1101/2025.04.30.651354 — microbiology — Posted on 2025-04-30

74 Anoxia activates CRISPR-Cas immunity in the intestine

Campbell, I. W.; Basta, D. W.; Zingl, F. G.; Sullivan, E. J.; Doranga, S.; Waldor, M. K.

10.1101/2025.04.30.651551 — microbiology — Posted on 2025-04-30

75 MAVS Orchestrates a Potent IFN-independent Antiviral Immunity by Preserving Mitochondrial Integrity

Sah, V.; Potharaju, P. S.; Nair, K. S.; Sahoo, P. P.; Pooja, A. R.; Basu, D.; Tandel, D.; Varadarajan, K. S.; Chauhan, S.; Patel, A. B.; Harshan, K. H.

10.1101/2025.04.28.651145 — immunology — Posted on 2025-04-30

76 Genetic differentiation in Anopheles stephensi from India and Ethiopia: insights from mitochondrial genome analysis

Gupta, B.; Sumitha, M. K.; Kalimuthu, M.; Pandiyan, G. N.; Natarajan, R.; Gopalakrishnan, S.; Paramasivan, R.; Rahi, M.; Kumar, A.

10.1101/2025.04.28.650555 — zoology — Posted on 2025-04-30

77 Whole-genome sequencing reveals the molecular basis of sex determination in the dioecious wild yam Dioscorea tokoro

Kudoh, A.; Natsume, S.; Sugihara, Y.; Kato, H.; Abe, A.; Oikawa, K.; Shimizu, M.; Itoh, K.; Tsujimura, M.; Takano, Y.; Sakai, T.; Adachi, H.; Ohta, A.; Ohtsu, M.; Ishizaki, T.; Terachi, T.; Terauchi, R.

10.1101/2025.04.28.650915 — plant biology — Posted on 2025-04-30

78 SARS-CoV-2 variants exhibit differential gut tropism and dysbiosis in Syrian golden hamsters.

Nagraj, S. K.; Joy, C. M.; Narayan, R.; Shiraz, R.; Kaur, S.; Khatun, O.; Dubey, S.; Ng, J.; MISHRA, N.; Tripathi, S.

10.1101/2023.06.19.545534 — pathology — Posted on 2025-04-30

79 Cation-controlled assembly, activity, and organisation of biomimetic DNA receptors in synthetic cell membranes

Peters, E.; Tanase, D. A.; Di Michele, L.; Rubio-Sanchez, R.

10.1101/2025.04.27.650532 — biophysics — Posted on 2025-04-30

80 Small molecule bioactivity benchmarks are often well-predicted by counting cells

Seal, S.; Dee, W.; Shah, A.; Zhang, A.; Titterton, K.; Cabrera, A. A.; Boiko, D.; Beatson, A.; Puigvert, J. C.; Singh, S.; Spjuth, O.; Bender, A.; Carpenter, A. E.

10.1101/2025.04.27.650853 — bioinformatics — Posted on 2025-04-30

81 PepSeek: Universal Functional Peptide Discovery with Cooperation Between Specialized Deep Learning Models and Large Language Model

Gong, H.; Wang, Y.; Kong, Q.; Li, X.; Li, L.; Wan, B.; Zhao, Y.; Chen, G.; Chen, J.; Zhang, J.; Yu, Y.; Yang, X.; Zuo, X.; Li, Y.

10.1101/2025.04.29.641945 — bioinformatics — Posted on 2025-04-30

82 Cryptic intronic transcriptional initiation generates efficient endogenous mRNA templates for C9orf72-associated RAN translation

Miller, S. L.; Green, K. M.; Crone, B.; Switzenberg, J. A.; Tank, E. M.; Krans, A.; Jansen-West, K.; Wieland, C.; Ji, E.; Petrucelli, L.; Barmada, S.; Boyle, A. P.; Todd, P.

10.1101/2025.04.27.650888 — neuroscience — Posted on 2025-04-30

83 Whey Protein Phospholipid Concentrate Supplementation Prevents High-Fat Diet Induced Cognitive Impairment in Wistar Rats by Promoting Brain Neuronal Connectivity and Sphingolipid Clearance

Sylvestre, D. A.; Liang, N.; Galan, J. G.; Safar, A. M.; Souza, F. D.; Bancks, M. C.; Sundaram, V. S.; Scott, B. W.; Schalich, K.; Goodson, M. L.; Rutkowsky, J. M.; Galang, K. G.; Ozturk, G.; Mills, D. A.; Barile, D.; Taha, A. Y.

10.1101/2025.04.29.647813 — neuroscience — Posted on 2025-04-30

84 Normal breast tissue classifiers assess large-scale tissue compartments with high accuracy

Chen, S.; Parreno-Centeno, M.; Booker, G.; Verghese, G.; Mohamed, F. S.; Arslan, S.; Pandya, P.; Oozeer, A.; D'Angelo, M.; Barrow, R.; Nelan, R.; Sobral-Leite, M.; Martino, F. d.; Brisken, C.; Smalley, M. J.; Lips, E.; Gillett, C.; Jones, L. J.; Banerji, C. R. S.; Pinder, S. E.; Grigoriadis, A.

10.1101/2025.04.27.649481 — pathology — Posted on 2025-04-30

85 Tumor-specific draining lymph node CD8 T cells orchestrate an anti-tumor response to neoadjuvant PD-1 immune checkpoint blockade

Honigsberg, R.; Cruz, T. D.; Yoffe, L.; Tang, M. S.; Ozgenel, D. O.; Markowitz, G.; Micheal, M.; Singh, A.; Altorki, N. K.; Elemento, O.; Villena-Vargas, J.

10.1101/2025.04.27.650862 — cancer biology — Posted on 2025-04-30

86 Increasing Stemness Drives Prostate Cancer Progression, Plasticity, Therapy Resistance and Poor Patient Survival

Liu, X.; Cortes, E.; Ji, Y.; Zhao, K.; Ho, J.; Liu, Y. S.; Davicioni, E.; Feng, F. Y.; Alumkal, J. J.; Spratt, D. E.; Sweeney, C. J.; Yu, H.; Hu, Q.; Cheng, Z.; Zhang, D.; Chatta, G.; Nastiuk, K. L.; Goodrich, D. W.; Rycaj, K.; Jamroze, A.; Kirk, J. S.; Puzanov, I.; Liu, S.; Wang, J.; Tang, D. G.

10.1101/2025.04.27.650697 — cancer biology — Posted on 2025-04-30

87 Surface-immobilized fibronectin conformation drives synovial fluid adsorption and film formation

Ahmed, S. T.; Honey, U.; Vitkova, L.; Pinto, D. R. J.; Flores, W.; Cutter, K. A.; Lunny, K. L.; Wen, Y.; De France, K.; Eguiluz, R. C. A.

10.1101/2025.04.27.650860 — biophysics — Posted on 2025-04-30

88 DiffPIE: Guiding Deep Generative Models to Explore Protein Conformations under External Interactions

Wang, Y.; Chen, M.

10.1101/2025.04.27.650875 — biophysics — Posted on 2025-04-30

89 SGCRNA: Spectral Clustering-Guided Co-Expression Network Analysis Without Scale-Free Constraints for Multi-Omic Data

Osone, T.; Takao, T.; Otake, S.; Takarada, T.

10.1101/2025.04.27.650628 — bioinformatics — Posted on 2025-04-30

90 Genome-wide identification and expression analysis of CDPK proteins in agarwood-producing Aquilaria agallocha trees

Begum, K.; Das, A.; Ahmed, R.; Akthar, S.; Banu, S.

10.1101/2025.04.27.650281 — bioinformatics — Posted on 2025-04-30

91 TransAgent: Dynamizing Transcriptional Regulation Analysis via Multi-omics-Aware AI Agent

Zhang, G.; Song, C.; Liu, L.; Wang, Q.; Li, C.

10.1101/2025.04.27.650826 — bioinformatics — Posted on 2025-04-30

92 Photobiological Hydrogen Production at Scale: Integrating Bioprocess Optimization and Techno-Economic Modeling

Elman, T.; Isaac, S.; Yacoby, I.

10.1101/2025.04.27.650233 — bioengineering — Posted on 2025-04-30

93 A Single Population Approach to Modeling Growth and Decay in Batch Bioreactors

Martinez, C.; Pere, M.

10.1101/2025.04.27.650866 — bioengineering — Posted on 2025-04-30

94 Early-life Helicobacter pylori infection worsens metabolic state in mice receiving a high-fat diet

Klove, S.; Graversen, K. B.; Agerbo Rasmussen, J.; Assis, J.; Schluter, J.; Blaser, M. J.; Andersen, S. B.

10.1101/2025.04.27.650497 — evolutionary biology — Posted on 2025-04-30

95 Beneficial fungi are major drivers of root fungal microbiome assembly and network robustness

Mosca, S.; Francomano, E.; Aci, M. M.; Mohamed, N. Z.; Schena, L.; Malacrino, A.

10.1101/2025.04.27.650865 — ecology — Posted on 2025-04-30

96 Forecasting Extinction Risk using Thermal Performance Curves and Population Dynamic Modeling

Vasseur, D. A.; Bieg, C.; Kummel, M.; Robey, A. J.

10.1101/2025.04.27.650737 — ecology — Posted on 2025-04-30

97 Dimethyl fumarate reprograms cervical cancer cells to enhance antitumor immunity by activating mtDNA-cGAS-STING pathway

Jiang, H.; Liu, L.; He, S.; Qu, S.; Yang, Y.; Kang, G.; Wu, M.; Liu, H.; Zhang, Y.; Chen, Y.; Wang, Z.; Wang, L.; Wang, Q.; Tian, W.; Ye, T.; Han, J.; Wang, H.; Huang, Y.

10.1101/2025.04.27.650830 — immunology — Posted on 2025-04-30

98 Sleep patterns predicting stress resilience are dependent on sex

Bush, B. J.; Mohamed, A.; Andrews, E.-J.; Cain, G.; Fawole, A.; Johnson, H.; Arocho, A.; Qiao, Z.; Paul, K. N.; Ehlen, J. C.

10.1101/2024.12.30.630808 — neuroscience — Posted on 2025-04-30

99 From Genes to Glands: Unraveling the Pivotal Influence of NtAGL66, an AGAMOUS-like Transcription Factor, on Glandular Trichome Development in Nicotiana tabacum

Berhin, A.; Walckiers, G.; Peeters, M.; El Amraoui, B.; Hachez, C.

10.1101/2025.04.27.650782 — plant biology — Posted on 2025-04-30

100 Dexamethasone-Induced p57-Mediated Quiescence Drives Chemotherapy Resistance in Sonic Hedgehog Medulloblastoma

Sharma, A.; Ellis, L.; Andrews, K.; Brown, A. S.; Fuller, M. T.; Scott, M. P.; Purzner, T.; Purzner, J.

10.1101/2025.04.27.650711 — cancer biology — Posted on 2025-04-30

101 Emergent Effect of Mixed Crowders on Protein Dimerization

Rath, R.; Biswas, M.

10.1101/2025.04.27.650838 — biophysics — Posted on 2025-04-30

102 The non-thermogenic function of opossum UCP1 is independent of its cytoplasmic binding network.

Roticiani, G.; Kreiter, J.; Pohl, E. E.

10.1101/2025.04.27.650829 — biophysics — Posted on 2025-04-30

103 SCRIPT: predicting single-cell long-range cis-regulation based on pretrained graph attention networks

Zhang, Y.; Jiao, Y.; Liu, Y.; Guo, X.; Wu, Y.; Li, J.; Han, L.; Xu, Y.; Gao, X.; Qi, Y.; Cheng, Y.; He, Y.

10.1101/2025.04.27.650894 — bioinformatics — Posted on 2025-04-30

104 MPI-Guided Photothermal Therapy of Prostate Cancer using Stem Cell Delivery of Magnetotheranostic Nanoflowers

Ghamei, B.; Rosu, A.; Kuddannaya, S.; Laurent, G.; Bazzi, R.; Roux, S.; Sakeri-Zadeh, A.; Bulte, J.

10.1101/2025.04.27.650870 — bioengineering — Posted on 2025-04-30

105 The pharmacodynamic inoculum effect from the perspective of bacterial population modeling

Baeder, D. Y.; Regoes, R. R.

10.1101/550368 — pharmacology and toxicology — Posted on 2025-04-30

106 Matrix Stiffness Regulates Mechanotransduction and Vascular Network Formation of hiPSC-Derived Endothelial Progenitors Encapsulated in 3D Hydrogels

Han, J.; Halwachs, K. N.; West, T.; Larsen, B. V.; Sacks, M. S.; Rosales, A.; Zoldan, J.

10.1101/2025.04.11.648340 — bioengineering — Posted on 2025-04-30

107 CISH, a novel intracellular immune checkpoint, in comparison and combination to existing and emerging cancer immune checkpoints

Cano, F.; Bravo Blas, A.; Colombe, M.; Cerrato, C.; Venegalla, R.; Preham, O.; Burns, E.; Mortimer, P.; Slipek, N.; Johnson, M. J.; Webber, B. R.; Moriarity, B. S.; Lou, E.; Choudhry, M.; Klebanoff, C. A.; Henley, T.

10.1101/2025.04.26.650767 — cancer biology — Posted on 2025-04-30

108 Packing of apolar amino acids is not a strong stabilizing force in transmembrane helix dimerization.

Loiseau, G. J.; Senes, A.

10.1101/2025.04.26.649789 — biophysics — Posted on 2025-04-30

109 Sludge liquefaction and stratification enable ultra-high digestion rate and resource recovery for waste activated sludge treatment

Wang, S.; Lu, Q.; Liang, Z.; Wang, C.; Shi, J.; Jia, B.; Liang, Y.; Jiang, D.; Liang, D.; Zhang, Y.; Dolfing, J.; Wang, P.; Wang, L.; Qiu, R.

10.1101/2025.04.27.650825 — bioengineering — Posted on 2025-04-30

110 A new clustering approach identifies tumor-specific common TCRs with pan-cancer reactivity

Hennig, S.; Gennermann, K.; Elezkurtaj, S.; Seitz, V.; Hirsch, B.; Droege, A.; Schaper, S.; Bents, D.; Eggeling, S.; Beushausen, C.; Herbst, H.; Genzel, N.; Gloekler, J.; Lennerz, V.; Woelfel, C.; Doppler, C.; Hammer, R.

10.1101/2025.04.26.650660 — immunology — Posted on 2025-04-30

111 Environmental enrichment selectively restores brain metabolic activity during cocaine abstinence

Belujon, P.; Lardeux, V.; Dugast, E.; Serriere, S.; Busson, J.; Bodard, S.; Tauber, C.; Galineau, L.; Solinas, M.

10.1101/2025.04.26.650753 — neuroscience — Posted on 2025-04-30

112 Single-dose DMT reverses anhedonia and cognitive deficits via restoration of neurogenesis in a stress-induced depression model.

Lima-da-Cruz, R. V.; Costa, R. B.; Queiroz, G. M.; Stojanovic, T.; Moulin, T.; LEAO, R. N.

10.1101/2025.04.26.650765 — neuroscience — Posted on 2025-04-30

113 Power-law memory governs bacterial adaptation and learning in fluctuating environments

Kratz, J.; Wang, H.; Si, F.; Banerjee, S.

10.1101/2025.04.26.650739 — systems biology — Posted on 2025-04-30

114 Reducing the CAV1-dependent trafficking of G6PC1 in the liver protects against the development of type 2 diabetes

Da Costa, L.; Saint-Beat, C.; Bron, C.; Lang, A.; Duchampt, A.; Micoud, M.; Evrard, F.; Mithieux, G.; Stein, A. G.

10.1101/2025.04.26.650768 — physiology — Posted on 2025-04-30

115 Immunotherapy for ovarian cancer is improved by tumor targeted delivery of a neoantigen surrogate

Scanlon, L. R.; Gabor, L.; Khouri, O. R.; Ahmad, S.; Levy, E.; Buckley, E.; Ouedraogo, A.; Kuo, D. Y.-S.; Lin, K.; Nevadunsky, N.; Isani, S.; Sun, S.; Gravekamp, C.

10.1101/2023.10.11.561944 — cancer biology — Posted on 2025-04-30

116 Investigating the prognostic value of KCNN4 gene expression in human pancreatic adenocarcinoma by bioinformatic analysis

Islam, S. S.; Tushar, M. M. H.; Sarkar, B.; Moni, R.; Zohora, U. S.; Rahman, M. S.

10.1101/2025.04.26.650766 — bioinformatics — Posted on 2025-04-30

117 The status of human goal-directed actions after manipulations of the action-outcome contingency

Perez, O. D.; Merlo, E.; Oh, S.; Arenas, J.; Dickinson, A.

10.1101/2025.04.26.650713 — animal behavior and cognition — Posted on 2025-04-30

118 Neural dynamics encoding risky choices during deliberation reveal separate choice subspaces

Peters, L.; Roadarmel, A.; Overton, J. A.; Stickle, M.; Lin, J.; Kong, Z.; Saez, I.; Moxon, K. A.

10.1101/2025.04.29.651314 — neuroscience — Posted on 2025-04-30

119 The human glucocorticoid receptor variant rs6190 promotes blood cholesterol and atherosclerosis

Durumutla, H. B.; Haller, A.; Noble, G.; Prabakaran, A. D.; McFarland, K.; Latimer, H.; Rajput, A.; Akinborewa, O.; Khales, B. N.; Hui, D. Y.; Quattrocelli, M.

10.1101/2024.11.27.625727 — physiology — Posted on 2025-04-30

120 SNX-2112 inhibits the ERBB3high tumor population in Plexiform Neurofibromas

Khan, S.; Aina, O.; Veneklasen, X.; Bruckert, B.; Njoya, K.; Alson, D.; Sun, L.; Zyaed, H.; Sun, D.

10.1101/2025.04.26.650740 — cancer biology — Posted on 2025-04-30

121 Plasma protein biomarkers for the early detection of gastric preneoplasia and cancer: a prospective study

Gianetto, Q. G.; Michel, V.; Douche, T.; Nozeret, K.; Zaanan, A.; Colussi, O.; Trouilloud, I.; Pernot, S.; Ungeheuer, M.-N.; Julie, C.; Jolly, N.; Taieb, J.; Lamarque, D.; Matondo, M.; Touati, E.

10.1101/2025.04.29.651246 — cancer biology — Posted on 2025-04-30

122 Characterizing structural and kinetic ensembles of intrinsically disordered proteins using writhe

Sisk, T. R.; Olsson, S.; Robustelli, P.

10.1101/2025.04.26.650781 — biophysics — Posted on 2025-04-30

123 Singe cell RNA sequencing data processing using cloud-based serverless computing

Hung, L.-H.; Nasam, N.; Lloyd, W.; Yeung, K. Y.

10.1101/2025.04.26.650787 — bioinformatics — Posted on 2025-04-30

124 On learning functions over biological sequence space: relating Gaussian process priors, regularization, and gauge fixing

Petti, S.; Marti-Gomez, C.; Kinney, J. B.; Zhou, J.; McCandlish, D. M.

10.1101/2025.04.26.650699 — bioinformatics — Posted on 2025-04-30

125 Brain-computer interface training fosters perceptual skills to detect errors

Liu, D. H.; Iwane, F.; Zhang, M.; Cohen, L.; Millan, J. d. R.

10.1101/2025.04.26.650792 — bioengineering — Posted on 2025-04-30

126 Characterizing Plasmodium falciparum genetic diversity and complexity of infections in clinical malaria infections in Western and Coastal Kenya using the poly-alpha microsatellite marker

Kimenyi, K. M.; Achieng, N.; Mgawe, C.; Ndwiga, L.; Oyier, L.

10.1101/2025.04.26.650801 — genetics — Posted on 2025-04-30

127 Nutritional stress adaptation shapes host microbiome stability and life history dynamics

Warren, P. K.; Miller, G.; Kandlikar, G. S.; Ng'oma, E.

10.1101/2025.04.26.650496 — evolutionary biology — Posted on 2025-04-30

128 Chromosome-level genome assembly of the lemon sole Microstomus kitt (Pleuronectiformes: Pleuronectidae)

Nebenfuehr, M.; Prochotta, D.; Nilsson, M. A.; de Jong, M. J.; Yasici, T. D.; Langefeld, F.; Wokoeck, H.; Jilg, J.; Bender, S. C.; Zangl, M. M.; Williams, K.; Janke, A.; Sonnewald, M.; Muloongo, M.; Ortega Guatame, J. M.

10.1101/2025.04.29.651060 — evolutionary biology — Posted on 2025-04-30

129 Subways, zoning and social factors influence the dispersal and genetic connectivity of an iconic urban pest, the brown rat (Rattus norvegicus) across a complex cityscape

Combs, M.; Munshi-South, J.

10.1101/2025.04.26.650778 — evolutionary biology — Posted on 2025-04-30

130 Habitat structural complexity increases age-class coexistence and population growth rate through relaxed cannibalism in a freshwater fish

Edeline, E.; Bennevault, Y.; Rozen-Rechels, D.

10.1101/2023.07.18.549540 — ecology — Posted on 2025-04-30

131 Coordinated Discordance: Strategic Nest Attendance for Chick Rearing in Monogamous Seabird

Ochi, D.; Oka, N.; Watanuki, Y.

10.1101/2025.04.26.650791 — ecology — Posted on 2025-04-30

132 Targeting Regulatory Factors Associated with the Drosophila Myc cis-Elements by Reporter Expression, Gel Shift Assay, and Mass Spectrometric Protein Identification

Kharazmi, J.; Brody, T.; Moshfegh, C.

10.1101/2025.04.04.647281 — molecular biology — Posted on 2025-04-30

133 Case study: Genomic characteristics of the gut microbiome, Campylobacter and Salmonella genotypes in three cases of gastroenteritis co-infections

Djeghout, B.; Rudder, S. J.; Le Viet, T.; Elumogo, N.; Langridge, G.; Janecko, N.

10.1101/2025.04.29.651233 — microbiology — Posted on 2025-04-30

134 Optimizing canine T cell activation, expansion, and transduction

Davis, T. W.; Holmes, J. C.; He, A.; Hess, P. R.; Mariani, C. L.; Brudno, Y.

10.1101/2025.04.26.650803 — immunology — Posted on 2025-04-30

135 Upper Airway Gene Expression in Hospitalized Children with Rhinovirus-induced Respiratory Illnesses

Kreger, J. E.; Sliwicki, A. L.; Essoh, S. N.; Li, Y.; Jayachandran, C.; Czapla, J. A.; Lewis, T. C.; Kirkham, E. M.; Vergotine, R. J.; Popova, A. P.; Flori, H. R.; Hershenson, M. B.

10.1101/2025.04.29.651288 — immunology — Posted on 2025-04-30

136 Proprioceptive and visual motion detection acuity contribute to children dynamic postural control

Iannotta, A.; Mongold, S. J.; Yldran Carlak, E.; Georgiev, C.; Cabaraux, P.; Van Dyck, D.; Naeije, G.; Van Der Ghinst, M.; Foucart, J.; Deconinck, N.; Bourguignon, M.

10.1101/2025.04.29.651175 — neuroscience — Posted on 2025-04-30

137 Comparative multi-omics profiling of Gossypium hirsutum and Gossypium barbadense fibers at high temporal resolution reveals key differences in polysaccharide composition and associated glycosyltransferases

Swaminathan, S.; Lee, Y.; Grover, C. E.; DeTemple, M. F.; Mugisha, A. S.; Sichterman, L. E.; Yang, P.; Xie, J.; Wendel, J. F.; Szymanski, D. B.; Zabotina, O. A.

10.1101/2025.04.26.650795 — plant biology — Posted on 2025-04-30

138 Salivary flow rate and prevalence of subjective halitosis in major depressive disorder patients

Althabhawee, A. A. H.; Zaidan, T. F.

10.1101/2025.04.26.650815 — physiology — Posted on 2025-04-30

139 A systematic review of the factors affecting sperm binding and release from the oviduct using in vitro experimental animal models

Sitali, M. C.; Chelenga, M.

10.1101/2025.02.03.636345 — physiology — Posted on 2025-04-30

140 SegMantX: a novel tool for detecting DNA duplications uncovers prevalent duplications in plasmids

Hanke, D. M.; Dagan, T.

10.1101/2025.03.14.643293 — bioinformatics — Posted on 2025-04-30

141 Robust Prediction of Multiple Protein Conformations with Entropy Guidance

Wu, D.; Feng, L.

10.1101/2025.04.26.650728 — bioinformatics — Posted on 2025-04-30

142 HIF-1α promotes osteogenic-angiogenic coupling response of BMSCs cell sheets

Zhang, D.; Teng, Y.; Huang, Y.; Liu, W.

10.1101/2025.04.26.650808 — bioengineering — Posted on 2025-04-30

143 Devising reliable and accurate epigenetic clocks: choosing the optimal computational solution

Vavourakis, C. D.; Herzog, C. M.; Widschwendter, M.

10.1101/2023.10.13.562187 — genomics — Posted on 2025-04-30

144 Latent dimensions in neural representations predict choice context effects

Madar, A.; Zemer, T.; Tavor, I.; Levy, D. J.

10.1101/2025.04.15.648989 — neuroscience — Posted on 2025-04-30

145 Regulation of sensorimotor serial learning in vocal pitch production for speech by motor compensation rather than sensory error

Lu, Y.; Tang, X.; Xiao, Z.; Xu, A.; Chen, J.; Tian, X.

10.1101/2024.10.27.620480 — neuroscience — Posted on 2025-04-30

146 SlimVar: rapid in vivo single-molecule tracking of chromatin regulators in plants

Payne-Dwyer, A.; Jang, G.-J.; Dean, C.; Leake, M. C.

10.1101/2024.05.17.594710 — plant biology — Posted on 2025-04-30

147 Expanding and applying reactivity-based protein profiling (RBPP) in Arabidopsis

Mooney, B. C.; Lyu, J.; Kaschani, F.; Kaiser, M.; van der Hoorn, R. A. L.

10.1101/2025.04.28.651067 — plant biology — Posted on 2025-04-30

148 The MpCAFA gene encodes a ciliary protein required for spermatozoid motility in the liverwort Marchantia polymorpha

MORITA, M.; Yamato, K. T.

10.1101/2025.04.26.650577 — plant biology — Posted on 2025-04-30

149 The cytochrome P450 enzyme MpCYP78E1 inhibits meristem initiation and activity in Marchantia polymorpha

Spencer, V.; Casey, C.; Mosiolek, M.; Jandrasits, K.; Edelbacher, N.; Dolan, L.

10.1101/2025.04.28.651025 — plant biology — Posted on 2025-04-30

150 Simultaneous stabilizing feedback control of linear and angular momentum in human walking

van Dieen, J. H.; Bruijn, S. M.; Lemaire, K. K.; Kistemaker, D. A.

10.1101/2025.01.09.632072 — biophysics — Posted on 2025-04-30

151 300 billion years of angiosperm evolution at risk of extinction

Forest, F.; Brown, R.; Buerki, S.; Colville, J. F.; Moat, J.; Lughadha, E. N.; Owen, N. R.; Raimondo, D. C.; Rivers, M.; Rosindell, J.; Walker, B. E.; Bachman, S. P.; Pipins, S.; Gumbs, R.; Brown, M. J. M.

10.1101/2025.04.29.651190 — evolutionary biology — Posted on 2025-04-30

152 Microglia Mitochondria Drive Neuronal Maturation via Metabolic and Transcriptional Reprogramming

Sterben, S. P.; Anamala, C. C.; Koduri, V.; Kansakar, S. B.; Liaudanskaya, V.

10.1101/2025.04.29.651306 — developmental biology — Posted on 2025-04-30

153 Mechanism of biomimetic virus-like nanoparticles in triggering immune response elucidated by proteomics

Wang, J.; Montaser, A.; Sivonen, M.; Leinonen, H.; Hepojoki, J.; Ma, L.; Lehto, V.-p.; Xu, W.

10.1101/2025.02.27.640536 — immunology — Posted on 2025-04-30

154 Calcium-permeable AMPAR in hippocampal parvalbumin-expressing interneurons protect against memory interference

Cooper, M.; Moniri, M.; Abuelem, M.; Bannerman, D. M.; Mann, E. O.

10.1101/2025.04.29.651201 — neuroscience — Posted on 2025-04-30

155 Neuroanatomical and behavioral characterization of corticotropin releasing factor-expressing lateral Habenula neurons in mice

Flerlage, W. J.; Gouty, S. C.; Thomas, E. H.; Simmons, S. C.; Tsuda, M. C.; Rujan, O.; Iyer, L.; Petrus, E. S.; Cox, B. M.; Wu, T. J.; Nugent, F. S.

10.1101/2025.04.29.651264 — neuroscience — Posted on 2025-04-30

156 Spatial Dynamics and Functional Connectivity in EEG: Insights from Lexical Processing

Aguilar, O. M. H.; Grullon, R.

10.1101/2025.04.29.651245 — neuroscience — Posted on 2025-04-30

157 Safety learning induces postsynaptic potentiation of direct pathway spiny projection neurons in the tail of the striatum

Stanley, A. T.; Choi, S. J.; Frank, A.; Makowicz, E.; Cataldi, S.; Shashaank, N.; Mosharov, E. V.; Lacefield, C.; Miniaci, M.; Sulzer, D.

10.1101/2025.04.29.651089 — neuroscience — Posted on 2025-04-30

158 Platelet concentrate-derived extracellular vesicles promote adult hippocampal neurogenesis

NyamErdene, A.; Thao Ngoc Lec, N.; Nebie, O.; Faivre, E.; Delila, L.; Chou, M. L.; Lowe, J.; Bantubungi, K.; BUEE, L.; Walker, T.; Blum, D.; Burnouf, T.

10.1101/2025.04.29.651163 — neuroscience — Posted on 2025-04-30

159 Functional Insights into Dispensable Genes using Genome-Wide Loss-of-Function Burden Tests in Arabidopsis

Zhao, K.; Lensink, M.; Monroe, J. G.

10.1101/2025.04.30.651390 — plant biology — Posted on 2025-04-30

160 A transcriptional atlas of early Arabidopsis seed development suggests mechanisms for inter-tissue coordination

Martin, C. A.; Cogdill, K. R.; Pusey, A. L.; Gehring, M.

10.1101/2025.04.29.651360 — plant biology — Posted on 2025-04-30

161 High-coverage, massively parallel sequencing of single-cell genomes with CAP-seq

Li, M.; Zhai, X.; Li, J.; Li, S.; Du, Y.; Zhang, J.; Zhang, R.; Luo, Y.; Wei, W.; Liu, Y.

10.1101/2024.09.10.612220 — genomics — Posted on 2025-04-30

162 Disentangling complex language contact and admixture in the broad Gansu-Qinghai region

Jin, H.; Tao, Y.; Yang, C.; Yang, S.; Sun, W.; Linguistic Silk Road Research Consortium, ; Xu, D.; Zhang, M.

10.1101/2025.04.28.650932 — evolutionary biology — Posted on 2025-04-30

163 Goblet cells mechanically breach the epithelial barrier in gut homeostasis

Creff, J.; He, Y.; Bernat-Fabre, S.; Buscail, E.; Neuvendel, S.; Krishnakumar, V.; Mangeat, T.; Xue, S.-L.; Krndija, D.

10.1101/2025.04.01.646617 — cell biology — Posted on 2025-04-30

164 Periventricular Diffusivity Reflects APOE4-modulated Amyloid Accumulation and Cognitive Impairment in Alzheimers Continuum

Chen, C.-L.; Son, S. J.; Schweitzer, N.; Jin, H.; Li, J.; Wang, L.; Yang, S.; Hong, C. H.; Roh, H. W.; Park, B.; Choi, J. W.; An, Y.-S.; Seo, S. W.; Cho, Y. H.; Hong, S.; Nam, Y. J.; Minhas, D. S.; Laymon, C. M.; Stetten, G. D.; Tudorascu, D. L.; Aizenstein, H. J.; Wu, M.; Mayo Clinic Study of Aging,

10.1101/2025.04.28.651021 — neuroscience — Posted on 2025-04-30

165 Predicting clinical phage therapy outcomes in vitro: results using mixed versus single isolates from an MRSA case study

Castledine, M.; Esom, C.; Van Nieuwenhuyse, B.; Djebara, S.; Merabishvili, M.; Pirnay, J.-P.; Buckling, A.

10.1101/2025.04.28.650979 — pathology — Posted on 2025-04-30

166 Pneumo-Typer: integrated genomic surveillance tool for capsule genotype, serotype and sequence type in Streptococcus pneumoniae informs vaccine strategies

Li, X.; Zhang, H.; Zhu, Y.; Yang, Z.; Wang, X.; Zhang, G.; Zhao, X.; Huang, Y.; Li, B.; Ma, Z.

10.1101/2025.02.13.638184 — bioinformatics — Posted on 2025-04-29

167 Transcriptomic analysis reveals immune signatures associated with specific cutaneous manifestations of lupus in systemic lupus erythematosus

Lee, E. Y.; Patterson, S.; Cutts, Z.; Lanata, C. M.; Dall'Era, M.; Yazdany, J.; Criswell, L. A.; Haemel, A.; Katz, P.; Ye, C. J.; Langelier, C.; Sirota, M.

10.1101/2025.04.27.649460 — bioinformatics — Posted on 2025-04-30

168 Estimation of total mediation effect for a binary trait in a case-control study for high-dimensional omics mediators

Kang, Z.; Chen, L.; Wei, P.; Xu, Z.; Li, C.; Yang, T.

10.1101/2025.01.28.635396 — genomics — Posted on 2025-04-29

169 Diverse Genomic Landscape of Swine Influenza A Virus in England (2014 - 2021)

Mollett, B. C.; Byrne, A. M. P.; Everett, H. E.; Reid, S. M.; Williamson, S.; Anderson, T. K.; James, J.; Banyard, A. C.; Brown, I. H.; Lewis, N. S.

10.1101/2025.04.28.650978 — genomics — Posted on 2025-04-30

170 Comparative Virome Profiling and Discovery of Novel Viruses in Managed and Wild Bees using RNA-seq

Li-Byarlay, H.

10.1101/2025.04.27.650873 — genomics — Posted on 2025-04-30

171 Immune Pressure is Key to Understanding Observed Patterns of Respiratory Virus Evolution in Prolonged Infections

Coats, A.; Wang, Y. R.; Koelle, K.

10.1101/2025.04.28.651059 — evolutionary biology — Posted on 2025-04-30

172 Alteration of long and short-term hematopoietic stem cell ratio causes myeloid-biased hematopoiesis

Nishi, K.; Sakamaki, T.; Nagasaka, A.; Kao, K. S.; Sadaoka, K.; Asano, M.; Yamamoto, N.; Takaori-Kondo, A.; Miyanishi, M.

10.1101/2024.01.18.576239 — developmental biology — Posted on 2025-04-29

173 Fluphenazine, an antipsychotic compound, ameliorates Alzheimer's disease by clearing amyloid beta accumulation in C. elegans

Devare, M. N.; Le, V.; Chung, V.; Vu, T.; Kaeberlein, M.

10.1101/2025.04.24.650484 — molecular biology — Posted on 2025-04-29

174 Impact of dupilumab and upadacitinib treatment on epigenetic and transcriptomic alterations in skin-homing T cells of atopic dermatitis patients

Elfiky, A. M. I.; Smits, H. M.; van der Wal, M.; Dekkers, C.; Boesjes, C. M.; Drylewicz, J.; de Bruin-Weller, M.; van Wijk, F.

10.1101/2025.04.28.650924 — immunology — Posted on 2025-04-30

175 The reward positivity is insensitive to reinforcer devaluation

Shaffer, L. S.; Crowder, H. D.; Kakalec, P. A.; Duong, L. T.; McDonald, C. G.; Thompson, J. C.

10.1101/2025.03.27.645774 — neuroscience — Posted on 2025-04-29

176 Temporal evolution of color representations measured with MEG reveals a 'coarse to fine' dynamic

Goddard, E.; Mullen, K. T.

10.1101/2024.12.19.629529 — neuroscience — Posted on 2025-04-29

177 Implantable Bioelectronics for Gut Electrophysiology

Boys, A. J.; Güemes, A. J.; Ma, L.; Gupta, R. A.; Lu, Z.; Lee, C.; El-Hadwe, S.; Carnicer Lombarte, A.; Naegele, T. E.; Uhlig, F. H.; Barone, D. G.; Bulmer, D. C.; Gelinas, J. N.; Hyland, N. P.; Khodagholy, D.; Malliaras, G. G.; Owens, R. M.

10.1101/2024.03.22.586292 — neuroscience — Posted on 2025-04-29

178 Genetic Foundations of Inter-individual Neurophysiological Variability

da Silva Castanheira, J.; Poli, J.; Hansen, J. Y.; Misic, B.; Baillet, S.

10.1101/2024.07.19.604292 — neuroscience — Posted on 2025-04-29

179 Digital Twin Brain Predicts rTMS Effects on Brain State Dynamics in Chronic Tinnitus

Zhang, J.; Han, S.; Shen, Y.; Wu, X.; Zhao, Y.; Wu, Z.; Luo, N.; Yang, Z.; Li, D.; Song, M.; Wu, P.; Tao, D.-d.; Liu, J.; Li, Y.; Jiang, T.

10.1101/2025.04.27.650883 — neuroscience — Posted on 2025-04-30

180 Functional connectivity patterns as an early indicator of later very early preterm outcomes

Gozdas, E.; Parikh, N.; He, L.; Hosseini, H.

10.1101/2025.04.27.650837 — neuroscience — Posted on 2025-04-30

181 Reservoir Computing with Bacteria

Ahavi, P.; Hoang, A.; Meyer, P.; Berthier, S.; Fiorini, F.; Castelli, F.; Epaulard, O.; Le Gouellec, A.; Faulon, J.-L.

10.1101/2024.09.12.612674 — systems biology — Posted on 2025-04-29

182 Prenatal exposure to dietary levels of glyphosate disrupts metabolic, immune, and behavioral markers across generations in mice.

Barnett, J. A.; Josephson, J. K.; Haskey, N. A.; Hart, M. M.; Soma, K. K.; Verdugo, A.; McComb, C. J.; Bandy, M. L.; Ghosh, S.; Letef, C.; Copp, A.; Ishida, R.; Yuzbashian, E.; Gibon, J.; Ye, J.; Giebelhaus, R. T.; Murch, S. J.; Jung, M. M.; Gibson, D. L.

10.1101/2024.08.27.609990 — pharmacology and toxicology — Posted on 2025-04-29

183 Longitudinal single-cell RNA sequencing of a neuroendocrine transdifferentiation model reveals transcriptional reprogramming in treatment-induced neuroendocrine prostate cancer

Sar, F.; Chung, H. C.; Lin, Y.-Y.; Lin, D.; Morova, T.; Haegert, A.; Volik, S.; Bell, R.; LeBihan, S.; Ozturan, D.; Xue, H.; Dong, X.; Wu, R.; Li, J.; Kung, H.-J.; Gleave, M. E.; Lack, N. A.; Wang, Y.; Collins, C. C.

10.1101/2025.04.25.650369 — cancer biology — Posted on 2025-04-29

184 Supervised learning of protein melting temperatures: cross-species vs species-specific prediction

Garcia Lopez, S.; Salomon, J.; Boomsma, W.

10.1101/2024.10.12.617972 — bioinformatics — Posted on 2025-04-29

185 Incorporating multi-scale module kernel for disease-gene identification in biological networks

Xiang, J.; Zeng, K.; Chen, S.; Meng, X.; Zheng, R.; Zheng, Y.; Long, Y.; Li, M.

10.1101/2022.07.28.501869 — bioinformatics — Posted on 2025-04-29

186 Structure-enabled enzyme function prediction unveils elusive terpenoid biosynthesis in archaea

Samusevich, R.; Hebra, T.; Bushuiev, R.; Engst, M.; Kulhanek, J.; Bushuiev, A.; Smith, J. D.; Calounova, T.; Smrckova, H.; Molineris, M.; Schwartz, R.; Tajovska, A.; Perkovic, M.; Chatpatanasiri, R.; Kampranis, S. C.; Major, D. T.; Sivic, J.; Pluskal, T.

10.1101/2024.01.29.577750 — biochemistry — Posted on 2025-04-29

187 Additive and substitutable prey responses to feral and native predator combinations.

St. Juliana, J. R.; Bleicher, S. S.; Mukherjee, S.; Sundararaj, V.; Brown, J. S.; Kotelr, B. P.

10.1101/2024.09.09.612031 — animal behavior and cognition — Posted on 2025-04-29

188 Detection of sex chromosomes in Tephritid pests using R-CQ and KAMY, two computational methods to enable species specific control.

Rallis, D.; Tsoumani, K. T.; Krsticevic, F.; Papathanos, P. A.; Gouvi, G.; Meccariello, A.; Mathiopoulos, K. D.; Papanicolaou, A.

10.1101/2023.10.27.564325 — genomics — Posted on 2025-04-29

189 Sexual reproduction is controlled by successive transcriptomic waves in Podospora anserina

Bidard, F.; Grognet, P.; Lelandais, G.; Imbeaud, S.; Mucchielli-Giorgi, M. H.; Debuchy, R.; Berteaux-Lecellier, V.; Malagnac, F.

10.1101/2024.12.09.627484 — genomics — Posted on 2025-04-29

190 Joint profiling of cell morphology and gene expression during in vitro neurodevelopment

Sundaresh, A.; Meistermann, D.; Lampela, R.; Yang, Z.; Woldegebriel, R.; Ganna, A.; Costa, P. P.; Kilpinen, H.

10.1101/2023.12.03.569583 — genomics — Posted on 2025-04-29

191 Platform-dependent effects of genetic variants on plasma APOL1

Wang, Q. S.; Huang, J.; Chan, L.; Haste, N.; Olsson, N.; Gaun, A.; McAllister, F.; Madhireddy, D.; Baruch, A.; Cardone, K. M.; Kumar, R.; Ritchie, M.; Susztak, K.; Melamud, E.; Baryshnikova, A.

10.1101/2025.01.30.635763 — genetics — Posted on 2025-04-29

192 Mechanisms of host exploitation by a microsporidian parasite

Silva, L. M.; Vallat, A.; Koella, J. C.

10.1101/2024.12.13.628237 — evolutionary biology — Posted on 2025-04-29

193 Genomics and reproductive biology of Leptopilina n. sp. Buffington, Lue, Davis & Tracey sp. nov. (Hymenoptera: Figitidae): An asexual parasitoid of Caribbean Drosophila

Lindsey, A. R.; Lue, C.-H.; Davis, J. S.; Borjon, L. J.; Mauthner, S. E.; Fricke, L. C.; Eads, L.; Murphy, M.; Drown, M. K.; Faulk, C.; Buffington, M. L.; Tracey, W. D.

10.1101/2025.03.28.645512 — evolutionary biology — Posted on 2025-04-29

194 Family-based Selection: An Efficient Method for Increasing Phenotypic Variability

Lall, S.; Milton, C.; de Bivort, B. L.

10.1101/2025.02.28.640850 — evolutionary biology — Posted on 2025-04-29

195 BABAPPA: A Bash-Based Automated Pipeline for Codeml-Mediated Selection Analysis Integrating PRANK and IQ-TREE2

Sinha, K.

10.1101/2025.04.27.650835 — evolutionary biology — Posted on 2025-04-29

196 Sample size considerations for species co-occurrence models.

Cowans, A.; Bonet Bigata, A.; Sutherland, C.

10.1101/2024.09.20.614180 — ecology — Posted on 2025-04-29

197 A Mechanistically Integrated Model of Exploitative and Interference Competition over a Single Resource Produces Widespread Coexistence

Smith, D. J. B.; Masel, J.

10.1101/2023.09.27.559600 — ecology — Posted on 2025-04-29

198 Divergence of germ cell-less roles in germ line development across insect species

Kao, J.; Ewen-Campen, B.; Extavour, C. G.

10.1101/2025.03.26.645619 — developmental biology — Posted on 2025-04-29

199 Distinct waves of ovarian follicles contribute to mouse oocyte production

Yin, Q.; Spradling, A. C.

10.1101/2024.05.30.596686 — developmental biology — Posted on 2025-04-29

200 CCDC32 stabilizes clathrin-coated pits and drives their invagination

Yang, Z.; Yang, C.; Huang, Z.; Xu, P.; Li, Y.; Han, L.; Peng, L.; Wei, X.; Pak, J.; Svitkina, T.; Schmid, S. L.; Chen, Z.

10.1101/2024.06.26.600785 — cell biology — Posted on 2025-04-29

201 The C-terminal regions of TRAK proteins contain MIRO-independent mitochondrial outer membrane binding domains

Mitchell, L.; Reda, K. E.; Fatima, H.; Vasquez, C. E.; Quintero-Carmona, O. A.

10.1101/2021.06.03.446977 — cell biology — Posted on 2025-04-29

202 Transcriptional antitermination integrates the expression of loci of diverse phage origin in the chimeric Bartonella Gene Transfer Agent BaGTA

Korotaev, A.; Niggli, Q.; Congedi, V.; Dehio, C.

10.1101/2024.11.20.624540 — microbiology — Posted on 2025-04-29

203 Universal rules govern plasmid copy number

Ramiro-Martinez, P.; de Quinto, I.; Gama, J. A.; Rodriguez-Beltran, J.

10.1101/2024.10.04.616648 — microbiology — Posted on 2025-04-29

204 Dual-format attentional template during preparation in human visual cortex

Chen, Y.; Liu, T.; Jia, K.; Theeuwes, J.; Gong, M.

10.1101/2024.09.12.602176 — neuroscience — Posted on 2025-04-29

205 ABCA7 Loss-of-Function Variants Impact Phosphatidylcholine Metabolism in the Human Brain

von Maydell, D.; Wright, S.; Pao, J.; Staab, C.; King, O.; Spitaleri, A.; Bonner, J. M.; Liu, L.; Yu, C. J.; Chiu, C.-C.; Leible, D.; Scannail, A. N.; Li, M.; Boix, C. A.; Mathys, H.; Leclerc, G.; Menchaca, G. S.; Welch, G.; Graziosi, A.; Leary, N.; Samaan, G.; Kellis, M.; Tsai, L.-H.

10.1101/2023.09.05.556135 — neuroscience — Posted on 2025-04-29

206 Striatal cholinergic interneuron pause response requires Kv1 channels, is absent in dyskinetic mice, and is restored by dopamine D5 receptor inverse agonism

Tubert, C.; Paz, R. M.; Stahl, A. M.; Sanchez Armijos, K.; Rela, L.; Murer, M. G.

10.1101/2024.05.31.596877 — neuroscience — Posted on 2025-04-29

207 Interrupting ELMSAN1 repression of nuclear Acetyl-CoA production therapeutically reprograms cancer cells

Zhao, T.; He, L.; Wong, L. P.; Mei, S.; Xia, J.; Xu, Y.; Van Vranken, J.; Mazzola, M.; Chen, L.; Rhee, C.; Fang, T.; Fukushima, T.; Sayles, L.; Diaz, M.; Gibbons, J. A. B.; Mostoslavsky, R.; Gygi, S. P.; Dou, Z.; Sykes, D. B.; Sadreyev, R.; Sweet-Cordero, A.; Scadden, D. T.

10.1101/2025.04.25.650293 — cancer biology — Posted on 2025-04-29

208 Inhibition Of One-Carbon Metabolism In Ewing Sarcoma Results In Profound And Prolonged Growth Suppression Associated With Purine Depletion

Zirpoli, S.; Copperman, N.; Patel, S.; Forrest, A.; Hou, Z.; Matherly, L. H.; Loeb, D. M.; Di Cristofano, A.

10.1101/2025.04.13.647987 — cancer biology — Posted on 2025-04-29

209 Osmotic Volume Flow in a Donnan System with PermeantIons

Manning, G. S.

10.1101/2024.07.22.604593 — biophysics — Posted on 2025-04-29

210 Deep contrastive learning enables genome-wide virtual screening

Jia, Y.; Gao, B.; Tan, J.; Zheng, J.; Hong, X.; Zhu, W.; Tan, H.; Xiao, Y.; Tan, L.; Cai, H.; Huang, Y.; Deng, Z.; Wu, X.; Jin, Y.; Yuan, Y.; Tian, J.; He, W.; Ma, W.; Zhang, Y.; Zhang, W.; Liu, L.; Yan, C.; Lan, Y.

10.1101/2024.09.02.610777 — bioinformatics — Posted on 2025-04-29

211 Massively parallel characterization of RNA G-quadruplex stability and molecular recognition

Martyr, J. G.; Guzman, B. B.; Hu, Y.; Rothacher, R. L.; Mustoe, A. M.; Aleman, M. M.; Dominguez, D.

10.1101/2025.04.29.651304 — biochemistry — Posted on 2025-04-29

212 Differential effects of chronic restraint stress on two active avoidance tasks in rats

Lopez-Moraga, A.; De Ceuninck, M.; Van der Heyden, Y.; Vercammen, L.; Palme, R.; Vervliet, B.; Beckers, T.; Luyten, L.

10.1101/2025.02.28.640742 — animal behavior and cognition — Posted on 2025-04-29

213 DeePosit: an AI-based tool for detecting mouse urine and fecal depositions from thermal video clips of behavioral experiments

Peles, D.; Netser, S.; Ray, N.; Suliman, T.; Wagner, S.

10.1101/2024.06.24.600419 — animal behavior and cognition — Posted on 2025-04-29

214 Transposable elements are vectors of recurrent transgenerational epigenetic inheritance in nature

Baduel, P.; De Oliveira, L.; Caillieux, E.; Bohl-Viallefond, G.; Xu, C.; El Messaoudi, M.; Barois, M.; Singh, V.; Sarazin, A.; Teixeira, F. K.; Boccara, M.; Gilbault, E.; de France, A.; Quadrana, L.; Loudet, O.; Colot, V.

10.1101/2024.09.20.614076 — genomics — Posted on 2025-04-29

215 Demographic history explains mitochondrial genome capture and mitonuclear discordance among South American collared Tropidurus lizards

Salles, M. M. A.; Carvalho, A. L. G.; Leache, A. D.; Martinez, N.; Bauer, F.; Motte, M.; Espinola, V.; Rodrigues, M. T.; Piantoni, C.; Pie, M. R.; Olivotto, A.; Colli, G. R.; Choueri, E. L.; Werneck, F. P.; Domingos, F. M. C. B.

10.1101/2025.04.25.650633 — genomics — Posted on 2025-04-29

216 Mutational signature catalogue (MUSIC) of DNA double-strand break repair

Barazas, M.; van Schendel, R.; Tijsterman, M.

10.1101/2025.04.29.650617 — genetics — Posted on 2025-04-29

217 Exogenous dsRNA made accessible to Dicer by two eukaryotic RNA-dependent RNA polymer-ases

Pirritano, M.; Buescher, J.; Staubach, P.; Tacken, T.; Yakovleva, Y.; Sabura, M.; Shehu, K.; Franzenburg, S.; Schneider, M.; Simon, M.

10.1101/2025.04.26.650694 — genetics — Posted on 2025-04-29

218 The absence of the ompA and type VI secretion system in the successful lineage of Acinetobacter baumannii ST19

Valcek, A.; Strachinaru, I.; Nesporova, K.; Soentjens, P.; Stoefs, A.; Van der Henst, C.

10.1101/2025.04.29.651177 — microbiology — Posted on 2025-04-29

219 An AINTEGUMENTA phospho-switch controls bilateral stem cell activity during secondary growth

Xiao, W.; Yang, L.; Ji, H.; Molina, D.; Chen, H.; Yu, S.; Miao, Y.; Ripper, D.; Deng, S.; Bayer, M.; De Rybel, B.; Ragni, L.

10.1101/2024.06.20.599823 — plant biology — Posted on 2025-04-29

220 A Functional Assay For Mining Non-Inhibitory Enzyme Ligands From One Bead One Compound Libraries: Application to E3 Ubiquitin Ligases

Gui, W.; Goss, A.; Kodadek, T.

10.1101/2025.04.29.651224 — biochemistry — Posted on 2025-04-29

221 Phosphorus fertility regulates microbial carbon use efficiency and SOM decomposition in non-allophanic Andosols

KOIZUMI, W.; CLOUGH, T. J.; KOJIMA, S.; MAKINO, T.; SUGIHARA, S.; TAJIMA, R.; UCHIDA, Y.; HAMAMOTO, T.

10.1101/2025.04.29.651165 — biochemistry — Posted on 2025-04-29

222 Impact of temperature on vector competence of Culex pipiens molestus: implications for Usutu virus transmission in temperate regions

Seechurn, N.; Pilgrim, J.; Sherlock, K.; Tanianis-Hughes, J.; Blagrove, M.; Hughes, G.; Johnson, N.; Baylis, M.

10.1101/2025.04.29.651192 — molecular biology — Posted on 2025-04-29

223 Typhoid toxin of Salmonella enterica induces ISG15 response mediating host cell survival and bacterial dissemination

Stark, D. S.; King, M.; Ibler, A. E.; Baseer, N.; Vernon, E. G.; Zhang, Y.; Staples, C.; Radoshevich, L.; Humphreys, D.

10.1101/2025.04.29.649991 — microbiology — Posted on 2025-04-29

224 Linking Oxygen-Induced Oxidative Stress to Resource Recovery by Enhancing the Production of Extracellular Polymeric Substances in Activated Sludge Microbial Communities

Zhou, X.; Manna, B.; Lyu, B.; Singhal, N.

10.1101/2025.04.29.651171 — microbiology — Posted on 2025-04-29

225 Effects of Willow and Pine tree growth in bacterial abundance, interactions and metabolic profile in a copper mine tailing

Ortega, J.; Galvez, G.; Serrano, G.; Torres, J.; Aliaga-Tobar, V.; Vilches, E.; Reyes, A.; Maracaja-Coutinho, V.; Parra, V.; Di Genova, A.; Pizarro, L.; Latorre, M.

10.1101/2025.04.28.651128 — microbiology — Posted on 2025-04-29

226 Responses of Soil Bacterial Community and Its Resistome to Short-term Exposure to Macrolide Antibiotic Macrolactin A: Metagenomic analysis

Poshvina, D. V.; Balkin, A. S.; Dilbaryan, D. S.; Vasilchenko, A. S.

10.1101/2025.04.29.651243 — microbiology — Posted on 2025-04-29

227 CertPrime: a new oligonucleotide design tool for gene synthesis

Luna-Cerralbo, D.; Serrano, A.; Blasco-Machin, I.; Hamdan, F.; Martinez-Olivan, J.; Broset, E.; Bruscolini, P.

10.1101/2025.04.29.650686 — synthetic biology — Posted on 2025-04-29

228 Controlling the taxonomic composition of biological information storage in 16S ribosomal RNA

Gamas, K. R.; Seamons, T.; Dysart, M.; Fang, L.; Chappell, J.; Stadler, L.; Silberg, J.

10.1101/2025.04.29.651329 — synthetic biology — Posted on 2025-04-29

229 Robust and Reliable de novo Protein Design: A Flow-Matching-Based Protein Generative Model Achieves Remarkably High Success Rates

Yan, J.; Cui, Z.; Yan, W.; Chen, Y.; Pu, M.; Li, S.; Ye, S.

10.1101/2025.04.29.651154 — bioengineering — Posted on 2025-04-29

230 A mutation at the dimer interface regulates catalysis

Hatton, C. E.; Falkenburg, L.; Mehrabi, P.

10.1101/2025.04.29.650001 — biochemistry — Posted on 2025-04-29

231 Widespread promiscuous alkaline phosphatases underscore early microbial phosphite utilization

Sakuma, M.; Konno, N.; Gholipour, S.; Chen, J. Z.; Tokuriki, N.

10.1101/2025.04.29.651336 — biochemistry — Posted on 2025-04-29

232 SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

Lehmkuhl, I.; Amin, K.; Hampel, N.; Iram, A.; Hesse, J.; Wiek, C.; Nguyen, J. T. V.; Hanenberg, H.; Scheller, J.; Ahmadian, M. R.; Stork, B.; Floss, D. M.; Piekorz, R. P.

10.1101/2025.04.29.649368 — biochemistry — Posted on 2025-04-29

233 Macromolecular Crowding-Affected Mobility of Bcnt/Cfdp1, a Disordered Component of the Srcap Complex, from the Nucleus to Cytosol in Subcellular Fractionation

Iwashita, S.; Suzuki, T.; Nishimura, K.; Onishi, A.; Tsukuda, K.; Kakihara, Y.; Kiriyama, Y.; Ohoka, Y.; Nakashima, K.

10.1101/2025.04.28.651124 — biochemistry — Posted on 2025-04-29

234 Genomic comparison of highly related pairs of E. coli and K. pneumoniae isolated from faeces and blood of the same neonatal patients hospitalized with fever in Dar es Salaam, Tanzania

Goodman, R. N.; Moyo, S. J.; Memelis, I.; Khanijau, A.; Manyahi, J.; Kibwana, U. O.; Aboud, S.; Blomberg, B.; Langeland, N.; Roberts, A. P.

10.1101/2025.04.28.650962 — genomics — Posted on 2025-04-29

235 MYC and AP-1 oncogenes synergistically bind enhancers to rewire transcription

Kalyan Sundaram, R.; Radhakrishnan, R.; Lim, B.

10.1101/2025.04.28.650480 — genomics — Posted on 2025-04-29

236 A Y-linked duplication of anti-Mullerian hormone is the sex determination gene in threespine stickleback

Treaster, M. J.; McCann, J.; Solovei, K. S.; Palmieri, R. J.; White, M. A.

10.1101/2025.04.28.650899 — genetics — Posted on 2025-04-29

237 Genetic Modulation of Lifespan: Dynamic Effects, Sex Differences, and Body Weight Trade-offs

Arends, D.; Ashbrook, D. G.; Roy, S.; Lu, L.; Sloan, Z. A.; Centeno, A. G.; Lamour, K. H.; de Magalhaes, J. P. W.; Prins, P.; Broman, K. W.; Sen, S.; Mitchell, S. J.; MacArthur, M. R.; Akin, O. A.; Auwerx, J.; Bajwa, A.; Harrison, D. H.; Strong, R.; Nelson, J. F.; Mozhui, K.; Williams, E. G.; Miller, R. A.; Williams, R. W.; Diaz, V.

10.1101/2025.04.27.649857 — genetics — Posted on 2025-04-29

238 Pleiotropic functions of an antenna-specific odorant binding protein linking xenobiotic adaptation and olfaction in the Colorado potato beetle, Leptinotarsa decemlineata

Abendroth, J. A.; Moural, T. W.; Cruse, C.; Hernandez, J. A.; Wolfin, M. S.; Baker, T. C.; Alyokhin, A.; Zhu, F.

10.1101/2025.04.29.651160 — molecular biology — Posted on 2025-04-29

239 Derepression of a single microRNA target causes female infertility in mice

Stefano, J.; Elcavage, L. E.; Hong, S.-J.; Bartel, D. P.; Kleaveland, B.

10.1101/2025.04.29.651088 — molecular biology — Posted on 2025-04-29

240 mRNA-delivered neutralizing antibodies confer protection against SARS-CoV-2 variant in the lower and upper respiratory tract

Hazell, N. C.; Reyna, R. A.; Bonam, S. R.; Bei, J.; Kumar, N.; Nguyen, T. N.; Plante, J. A.; Walker, D. H.; Wang, T.; Plante, K. S.; Hu, H.

10.1101/2025.04.28.650951 — microbiology — Posted on 2025-04-29

241 Highly potent antiviral drug candidates targeting SARS-CoV-2 nsp3 and nsp5

Galais, M.; HERLEM, G.; HAIDAR AHMAD, S.; Pasquereau, S.; EL BABA, R.; BELLEFROID, M.; PLANT, E.; MOROT-BIZOT, S.; PICAUD, F.; HERBEIN, G.; Van Lint, C. M.

10.1101/2025.04.28.650947 — microbiology — Posted on 2025-04-29

242 Mapping the transcriptional landscape of algal resistance to viral infection reveals a core expression program

Shaler, T.; Fromm, A.; Schatz, D.; Ben-dor, S.; Feldmesser, E.; Vardi, A.

10.1101/2025.04.29.650402 — microbiology — Posted on 2025-04-29

243 Methylene Blue-Photodynamic Therapy Effectively Kills Antibiotic-Resistant Bacteria from Pediatric Patients with Perforated Appendicitis

Wirth, K. T.; Wang, E. Y.; Hawryluk, D. S.; Byrne, M. M.; Arca, M. J.; Wakeman, D. S.; Pegoli, W.; Darcy, D. G.; Pavelka, M. S.; Wilson, N. A.; Baran, T. M.

10.1101/2025.04.29.651230 — microbiology — Posted on 2025-04-29

244 Cryo-EM structure of a cell-free synthesized full-length human β1-adrenergic receptor in complex with Gs

Merino, F.; Koeck, Z.; Ermel, U. H.; Dahlhaus, P.; Grimm, A.; Seybert, A.; Kubicek, J.; Frangakis, A. S.; Doetsch, V.; Hilger, D.; Bernhard, F.

10.1101/2025.04.29.651181 — biochemistry — Posted on 2025-04-29

245 Nucleosome context regulates chromatin reader preference

Marunde, M. R.; Popova, I. K.; Hall, N. W.; Vaidya, A.; Bone, J. R.; Boone, B. A.; Brown, P. J.; Ezell, R. J.; Firestone, T. M.; Fuchs, H. A.; Gibson, E.; Gillespie, Z. B.; Gloor, S. L.; Hickman, A. R.; Howard, S. A.; Husby, N. L.; Hsiung, V. T.; Johnstone, A. L.; Khan, L. F.; Krajewski, K.; Lee, A. S.; McAnarney, E. T.; Maier, K. E.; Maryanski, D. N.; Noll, K. E.; Novitzky, K.; Patteson, E. F.; Rodriguez, K. L.; Sanchez, J. C.; Schachner, L. F.; Smith, C. E.; Sun, L.; Taylor, H. F.; Watson, R.; Willis, H. E.; Musselman, C. A.; Venters, B. J.; Cheek, M. A.; Meiners, M. J.; Sun, Z.-W.; Kelleher

10.1101/2025.04.29.651129 — biochemistry — Posted on 2025-04-29

246 miR-631 targets the oncogene RAB11A: implications for oral squamous cell carcinoma pathogenesis and therapeutics

Pulakkat Muralidharan, H.; Mishra, R.; Gopal, C.; Kumar, A.

10.1101/2025.04.26.650806 — cancer biology — Posted on 2025-04-29

247 Discovery of a tRNA-regulatory transcription factor that suppresses breast cancer metastasis

Chen, S.; Markett, D.; Karimzadeh, M.; Luo, Y.; Khoroshkin, M. S.; Boyraz, B.; Lee, S.; Carpenter, C.; Nguyen, P.; Garcia, K.; Joshi, T.; Martin, C.; Hanisch, B.; Molina, H.; Tavazoie, S.; Ramani, V.; Navickas, A.; Goodarzi, H.

10.1101/2025.04.26.650725 — genomics — Posted on 2025-04-29

248 Extrachromosomal DNA Gives Cancer a New Evolutionary Pathway

Wang, Y.; Cope, O.; Chen, J.; Mehta, A.; Fleifel, D.; Ford, C.; Benhamie, P.; Haase, S.; Gulec, S.; Elston, T.; Spanheimer, P. M.; Tomblin, C. A.; Rojas, A.; Tate, T.; Purvis, J.; Wang, J. R.; Dahl, J. M.; Wolff, S. C.; Cook, J.; Brunk, E. C.

10.1101/2025.04.26.650733 — genomics — Posted on 2025-04-29

249 Actin cytoskeletal deregulation, caused by RhoGEF2 overexpression, induces cell competition dependent on Ptp10D, Crumbs, and the Hippo signaling pathway.

Fahey-Lozano, N.; Portela, M.; La Marca, J. E.; Richardson, H. E.

10.1101/2025.04.26.650750 — developmental biology — Posted on 2025-04-29

250 Type I interferons enhance human dorsal root ganglion nociceptor excitability and induce TRPV1 sensitization

Franco-Enzastiga, U.; Natarajan, K.; Espinosa, F.; Granja-Vazquez, R.; Mydugolam, H.; Price, T. J.

10.1101/2025.04.22.650068 — neuroscience — Posted on 2025-04-29

251 Degraded mapping of disparity tuning in visual cortex explains deficits in binocular depth perception

Brown, T. C.; Barr, C.; Antin, M.; Nguyen, V.; McGee, A. W.; Samonds, J. M.

10.1101/2025.04.22.649872 — neuroscience — Posted on 2025-04-29

252 Thalamic NRXN1-Mediated Input to Human Cortical Progenitors Drives Upper Layer Neurogenesis

Nguyen, C. V.; Martija, A.; Nano, P. R.; Soto, J. A.; Jaklic, D. C.; Mil, J.; White, R.; Martin, J. M.; Rana, D.; Geschwind, D. H.; Bhaduri, A.

10.1101/2025.04.25.650717 — neuroscience — Posted on 2025-04-29

253 Characterizing semantic compositions in the brain: A model-driven fMRI re-analysis

Ciapparelli, M.; Marelli, M.; Graves, W.; Reverberi, C.

10.1101/2025.04.25.650708 — neuroscience — Posted on 2025-04-29

254 Effect of Transcranial Light Stimulation on the Neurovascular Unit in the Human Brain

Zhao, C.; Li, Z.; Ding, Z.; Zhang, K.; Li, Y.; Zhang, L.; Zou, Q.; Gao, Z.; Cui, Z.; Li, X.

10.1101/2025.04.23.649937 — neuroscience — Posted on 2025-04-29

255 Separable Dorsal Raphe Dopamine Projections Mimic the Facets of a Loneliness-like State

Lee, C. R.; Matthews, G. A.; Lemieux, M. E.; Wasserlein, E. M.; Borio, M.; Miranda, R. L.; Keyes, L. R.; Schneider, G. P.; Jia, C.; Tran, A.; Aloboudi, F.; Chan, M. G.; Peroni, E.; Pereira, G. S.; Lopez-Moraga, A.; Palle, A.; Kimchi, E. Y.; Padilla-Coreano, N.; Wichmann, R.; Tye, K. M.

10.1101/2025.02.03.636224 — neuroscience — Posted on 2025-04-29

256 Computing the effects of excitatory-inhibitory balance on neuronal input-output properties

Reyes, A.

10.1101/2025.03.09.642210 — neuroscience — Posted on 2025-04-29

257 A Cross-Species Generative Cell Atlas Across 1.5 Billion Years ofEvolution: The TranscriptFormer Single-cell Model

Pearce, J. D.; Simmonds, S. E.; Mahmoudabadi, G.; Krishnan, L.; Palla, G.; Istrate, A.-M.; Tarashansky, A.; Nelson, B.; Valenzuela, O.; Li, D.; Quake, S. R.; Karaletsos, T.

10.1101/2025.04.25.650731 — systems biology — Posted on 2025-04-29

258 Orbitofrontal Cortex Influences Dopamine Dynamics Associated with Alloparental Behavioral Acquisition in Female Mice

Tasaka, G.-i.; Hagihara, M.; Irie, S.; Kobayashi, H.; Inada, K.; Kobayashi, K.; Kato, S.; Kobayashi, K.; Miyamichi, K.

10.1101/2023.02.03.527077 — neuroscience — Posted on 2025-04-29

259 Non-duality in brain and experience of advanced meditators - Key role for Intrinsic Neural Timescales

Malipeddi, S.; Sasidharan, A.; Ventura, B.; Venugopal, R.; Bauer, C. C.; Tewarie, P. K. B.; Ravindra, P. N.; Mehrotra, S.; John, J. P.; Subramaniam, B.; Laureys, S.; Kutty, B. M.; Northoff, G.

10.1101/2025.04.21.649758 — neuroscience — Posted on 2025-04-29

260 Heparan sulfate glycosaminoglycans mediate CXCL4 (PF4) transport across the blood-brain barrier and effects on neurogenesis

Weaver, R. R.; Gray, A. L.; Mateus-Gomes, S.; Ridley, A. J.; Giblin, S. P.; Birchenough, H. L.; Peterson, F. C.; Mulholland, I. Z.; Lowe, K. O.; Schiessl, I.; Jowitt, T. A.; Pease, J. E.; Banks, W. A.; Rua, R.; Erickson, M. A.; Dyer, D. P.

10.1101/2025.04.23.650173 — neuroscience — Posted on 2025-04-29

261 Hypothalamic deiodinase type-3 establishes the period of circannual interval timing in mammals

Stewart, C.; Liddle, T. A.; Tolla, E.; Lewis, J. E.; Marshall, C.; Evans, N. P.; Morgan, P. J.; Ebling, F. J.; Stevenson, T. J.

10.1101/2025.04.22.650143 — neuroscience — Posted on 2025-04-29

262 Spatiotemporal Analysis of Remyelination Reveals a Concerted Interferon-Responsive Glial State That Coordinates Immune Infiltration

Dolan, M.-J.; Rakosi-Schmidt, R.; Garcia, E.; Lin, Y.; Nadaf, N. M.; Dixon, J.; Guo, S.; Morshed, N.; Depp, C.; Doman, J.; Xia, J.; Jäntti, H.; Stevens, B.; Macosko, E. Z.

10.1101/2025.04.22.649486 — neuroscience — Posted on 2025-04-29

263 Neural trajectories reveal orchestration of cortical coding underlying natural language composition

Tang, X.; Booth, J. R.; Zhang, Y.; Wang, S.; Ding, G.

10.1101/2025.04.24.650382 — neuroscience — Posted on 2025-04-29

264 Organization of brainwide inputs to discrete lateral septum projection populations

Isaac, J.; Karkare, S.; Balasubramanian, H.; Murugan, M.

10.1101/2025.04.23.650257 — neuroscience — Posted on 2025-04-29

265 Quantum Magnetization Exchange through Transient Hydrogen Bond Matrix Defines Magnetic Resonance Signal Relaxation and Anisotropy in Central Nervous System

Yablonskiy, D. A.; Sukstanskii, A. L.

10.1101/2025.04.22.650086 — neuroscience — Posted on 2025-04-29

266 Survival of Transplanted Retinal Ganglion Cell in Human Donor Eyes under Elevated Pressure

Hameed, S. S.; Gupta, S. J.; Ho, K. K.; Sharma, T. P.

10.1101/2025.04.22.650064 — neuroscience — Posted on 2025-04-29

267 Cell type-specific contributions to impaired blood-brain barrier and cerebral metabolism in presymptomatic 5XFAD mice

Yao, M.; Sun, N.; Linville, R.; Wei, Z.; Kakazu, A.; Ouyang, Y.; Li, R.; Du, L.; Wang, H.; Zhou, Y.; Jiang, Y.; Zhang, Z.; Li, A.; Lu, H.; Xu, J.; Kellis, M.; Heiman, M.; Duan, W.

10.1101/2025.04.23.650260 — neuroscience — Posted on 2025-04-29

268 Telmisartan and Lisinopril Show Potential Benefits in Rescuing Cognitive-Behavioral Function Despite Limited Improvements in Neuropathological Outcomes in Tg-SwDI Mice

Motzko Noto, N.; Restrepo, Y. M.; Hernandez, A.; Vogel, C.; Pulido-Correa, V.; Moen, S.; Bonetti, J.; Chiduruppa, V.; Speth, R. C.; Robison, L. S.

10.1101/2025.04.23.650226 — neuroscience — Posted on 2025-04-29

269 Stochastic activity in low-rank recurrent neural networks

Mastrogiuseppe, F.; Carmona, J.; Machens, C.

10.1101/2025.04.22.649933 — neuroscience — Posted on 2025-04-29

270 Mapping Grip Force to Muscular Activity Towards Understanding Upper Limb Musculoskeletal Intent using a Novel Grip Strength Model

Lai, Y.; Abdel-messih, E.; Carmichael, M.; Paul, G.

10.1101/2024.12.30.630841 — physiology — Posted on 2025-04-29

271 Telomerase RNA gene duplications drive telomeric repeatdiversity and evolution in Andrena bees

Klapproth, C.; Israel, E.; Ahmed, A.; Remmel, A.; Kaether, K.-K.; Reinhardt, F.; Chen, J. J. L.; Prohaska, S. J.; Steidle, J.; Lemke, S.; Stadler, P. F.; Findeiss, S.

10.1101/2025.04.29.651168 — bioinformatics — Posted on 2025-04-29

272 Demographic history explains mitochondrial genome capture and mitonuclear discordance among South American collared Tropidurus lizards

10.1101/2025.04.25.650633 — genomics — Posted on 2025-04-29

273 LOSS OF ROR2 TYROSINE KINASE RECEPTOR IS ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION IN PAH VIA INAPPROPRIATE INTEGRIN BETA 1 ACTIVATION

Mitra, A.; Chakraborty, A.; Zhong, B.; Heo, L.; Agarwal, S.; Pacheco, A.; Auer, N.; Dunn, A.; Chelladurai, P.; Jain, A.; Matos, J.; Bankar, A.; Guardado, E.; YI, D.; Zhao, H.; Wai Dede Man, K.; Nair, R. V.; Guenat, O. T.; Dai, Z.; de Jesus Perez, V. A.

10.1101/2025.04.28.651135 — cell biology — Posted on 2025-04-29

274 Random UV Mutagenesis for the production of Chlorella vulgaris mutants with low chlorophyll content for the food industry

Ivanov, I. N.; Kopecky, J.; Sterbova, K.; Hrouzek, P.; Lukes, M.; Bisova, K.; Kurniawan, S. B.

10.1101/2025.04.28.651037 — cell biology — Posted on 2025-04-29

275 Estimating fMRI Timescale Maps

Riegner, G.; Davenport, S.; Voytek, B.; Schwartzman, A.

10.1101/2025.04.23.650300 — neuroscience — Posted on 2025-04-29

276 Pitfalls of mapping functional and molecular human brain imaging data from separate cohorts

Fisher, P. M.; Larsen, K.; Plaven-Sigray, P.; Knudsen, G. M.; Ozenne, B.

10.1101/2025.04.22.650037 — neuroscience — Posted on 2025-04-29

277 In Utero Exposure to Anti-Caspr2 Antibody Disrupts Parvalbumin Interneuron Function in the Hippocampus

Bagnall-Moreau, C.; Strohl, J.; Spielman, B.; Cruz, C.; Huerta, P.; Brimberg, L.

10.1101/2025.04.25.650362 — neuroscience — Posted on 2025-04-29

278 Bridging Stem Cell Models and Medicine: Integrated 3D Human Cerebral Organoids and Pediatric Serum Reveal Mechanisms and Biomarkers of Anesthetic-Induced Neurotoxicity

Pant, T.; Jiang, C.; Yan, Y.; Schultz, B.; Laws, D.; Logan, S.; Bedrat, A.; Juric, M.; Berens, R. J.; Taylor, S. P.; Henry, A. M.; Bosnjak, Z. J.; Bai, X.

10.1101/2025.04.23.650256 — neuroscience — Posted on 2025-04-29

279 Characterization of the functional and clinical impacts of CACNA1A missense variants found in neurodevelopmental disorders

Kurganov, E.; Cui, L.; Budnik, N.; Chen, S.; Olivares, E.; Baez-Nieto, D.; Lusk, L.; Smith, L.; Jo, S.; Mullegama, S. V.; Lindy, A.; George, A. L.; Poduri, A.; Helbig, I.; Daly, M.; Pan, J. Q.

10.1101/2025.04.23.650298 — neuroscience — Posted on 2025-04-29

280 Excitation-Inhibition Balance and Fronto-Limbic Connectivity Drive TMS Treatment Outcomes in Refractory Depression

Momi, D.; Wang, Z.; Oveisi, M. P.; Kadak, K.; Bastiaens, S. P.; Lissemore, J. I.; Noda, Y.; Downar, J.; Vila Rodriguez, F.; Strafella, R.; Daskalakis, Z. J.; Zrenner, C.; Zomorrodi, R.; Rolle, C. E.; Saggar, M.; Williams, N.; Keller, C. J.; Blumberger, D. M.; Voineskos, D.; Griffiths, J. D.

10.1101/2025.04.23.648963 — neuroscience — Posted on 2025-04-29

281 Early visual signatures and benefits of intra-saccadic motion streaks

Schweitzer, R.; Seel, T.; Raisch, J.; Rolfs, M.

10.1101/2025.04.23.650153 — neuroscience — Posted on 2025-04-29

282 A New Serological Autoantibody Signature Associated with Multiple Sclerosis

Abdesselem, H. B.; Van Benthem, A. D.; Bensmail, I.; Elbashir, I. E.; Tan, T.-M.; Abylova, B.; Koon, L.; Anuar, D.; Blackburn, J. M.; Malik, R. A.; Petropoulos, I. N.

10.1101/2025.04.23.650160 — neuroscience — Posted on 2025-04-29

283 Hypoxia Exacerbates Kir2.1 Channel Dysfunction in an Andersen-Tawil Syndrome Variant Through a SUMO-Dependent Mechanism

Chandrashekar, A.; Xu, Y.; Ma, X.; Yauch, A. K.; Scholl, E.; Yang, Y.; Gada, K. D.; Kawano, T.; Cui, M.; Plant, L. D.

10.1101/2025.04.25.650734 — physiology — Posted on 2025-04-29

284 Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females.

Patton, M. E.; Kelekar, S.; Taylor, L. J.; Dean, A. E.; Zuo, Q.; Thakare, R. N.; Lee, S. H.; Gentry, E.; Panitchpakdi, M.; Dorrestein, P.; Alnouti, Y.; Madak-Erdogan, Z.; Lee, J.-S.; Finegold, M. J.; Anakk, S.

10.1101/2020.06.25.172635 — cancer biology — Posted on 2025-04-29

285 NOTCH1 Acts as a Tumor Suppressor That Induces Early Differentiation in Head and Neck Cancer

Huang, C.; Moorthy, S.; Li, Q.; Ahmed, K. M.; Deng, D.; Wang, J.; Rao, X.; Zhang, J.; Xi, Y.; Wang, J.; Liu, Z.; Tanaka, N.; Wheeler, D. A.; Shibrot, E.; Saade, R.; Pickering, C. R.; Xie, T.-X.; El-Naggar, A. K.; Osman, A. A.; Rai, K.; Zweidler-McKay, P. A.; Heymach, J. V.; Byers, L. A.; Johnson, F. M.; Sandulache, V. C.; Myers, J. N.; Yadollahi, P.; Frederick, M. J.

10.1101/2025.04.25.650710 — cancer biology — Posted on 2025-04-29

286 Division of labor in cargo and membrane recognition by SNX1-SNX5: Insights from multiscale modelling

Duggisetty, S. C.; Kumar, G.; Baratam, K.; Srivastava, A.

10.1101/2025.04.27.650847 — biophysics — Posted on 2025-04-29

287 Anchors for Homology-Based Scaffolding

Kaether, K.-K.; Lemke, S.; Stadler, P. F.

10.1101/2025.04.28.650980 — bioinformatics — Posted on 2025-04-29

288 Microengineered transplantation of human solid tumors for in vitro studies of CAR T immunotherapy

Liu, H.; Noguera-Ortega, E.; Dong, X.; Lee, W. D.; Chang, J.; Aydin, S. A.; Li, Y.; Shin, Y.; Shi, X.; Liousia, M.; Martinez, M.; Brotman, J.; Kim, S.; Chen, Z.; Wang, A.; Ou, Z.; Paek, J.; Park, J. Y.; Liu, A.; Hu, H.; Xiao, Z.; Racca, D. M.; Kim, S.-j.; Worthen, G. S.; Guo, W.; Pure, E.; Kang, T.; Rabinowitz, J.; Wherry, E. J.; Moon, E.; Albelda, S.; Huh, D. D.

10.1101/2025.04.25.650709 — bioengineering — Posted on 2025-04-29

289 The Latentverse: An Open-Source Benchmarking Toolkit for Evaluating Latent Representations

Turura, Y.; Friedman, S. F.; Cremer, A.; Maddah, M.; Tonekaboni, S.

10.1101/2025.04.25.650676 — bioengineering — Posted on 2025-04-29

290 Modulating cell-free transcription electrolytically with switchable DNA triplexes

Speakman, A. J.; Dunn, K. E.

10.1101/2025.04.25.650642 — bioengineering — Posted on 2025-04-29

291 Bioprinting Taurine-Incorporated Gelatin Methacrylate Hydrogels for Enhanced Muscle Tissue Regeneration

Tabatabaei Rezaei, N.; Dixit, K.; Shrivas, S.; Kumar, H.; Kim, K.

10.1101/2025.04.25.650478 — bioengineering — Posted on 2025-04-29

292 Enhanced Temporal-Resolution CEST Imaging method for reliable mapping of muscle OXPHOS

Burman, R.; Finkel, R. S.; Ness, K. K.; Bag, A.; Pang, Y.; Bagga, P.

10.1101/2025.04.25.650537 — bioengineering — Posted on 2025-04-29

293 Functional Dissection of the Zdhhc5-GOLGA7 Protein Palmitoylation Complex

Kahlson, M. A.; Ritho, J.; Gomez, J. V.; Wang, H.; Butterwick, J.; Dixon, S. J.

10.1101/2025.04.28.651057 — biochemistry — Posted on 2025-04-29

294 A large global soil carbon sink informed by repeated soil samplings

Jia, R.; Fricke, E.; Malhotra, A.; Bar-On, Y. M.; Deng, J.; Pineiro, G.; Bazzoni, B.; Alvarez, R.; Findlay, N.; te Beest, M.; Zhou, Y.; Boutton, T. W.; Dar, J. A.; Kothandaraman, S.; MacDougall, A. S.; Eisenhauer, N.; Peri, P. L.; Zheng, J.; Power, S. A.; Reed, S. C.; Macek, P.; Haider, S.; Sitch, S.; O'Sullivan, M.; Friedlingstein, P.; Bond-Lamberty, B.; Hungate, B.; Jackson, R. B.; Subramanian, M.; Patel, K.; Terrer, C.

10.1101/2025.04.25.650716 — ecology — Posted on 2025-04-29

295 VGLL1 contributes to both the transcriptome and epigenome of the developing trophoblast compartment

Calderon, R. I.; Sah, N.; Huang, M.; Kittle, R. H.; Shaik, W.; Chousal, J. N.; Kallol, S.; Bui, T.; Morey, R.; Mitre, A.; Fogarty, N. M. E.; Gerri, C.; Zheng, C.; DeHoff, P. M.; Home, P.; Niakan, K.; Cook-Andersen, H.; Fisch, K. M.; Paul, S.; Soncin, F.

10.1101/2025.04.25.650693 — developmental biology — Posted on 2025-04-29

296 Microneedle delivery of stem cell derived retinal pigment epithelial cells

Ching, J.; Hinako, I.; Kitahata, S.; Morrow, L.; Kadonosono, K.

10.1101/2025.04.29.651158 — cell biology — Posted on 2025-04-29

297 High-throughput peptide-centric local stability assay extends protein-ligand identification to membrane proteins, tissues, and bacteria

Li, K.; Potel, C. M.; Becher, I.; Huettmann, N.; Garrido-Rodriguez, M.; Schwarz, J. J.; Savitski, M.

10.1101/2025.04.28.650974 — cell biology — Posted on 2025-04-29

298 Myo1e/f at the podosome base regulate podosome dynamics and promote macrophage migration

Cervero, P.; Barger, S. R.; Verdys, P.; Herzog, R.; Paul, T.; Palmieri, M.; Poincloux, R.; Linder, S.; Krendel, M.

10.1101/2025.04.28.651090 — cell biology — Posted on 2025-04-29

299 Basement Membrane Structural Integrity Dictates Trans-Tissue Deposition of Laminin in Mammals

Miner, J. H.; Omachi, K.; Yurchenco, P.; McKee, K. K.; Lin, M.-H.; Fujiwara, H.; Puapatanakul, P.

10.1101/2025.04.28.650774 — cell biology — Posted on 2025-04-29

300 ARAP2 regulates responses to interferon-gamma by restricting SOCS1

Keating, N.; Doggett, K.; Bidgood, G.; Guzman, L. G. M.; Dagley, L.; Li, K.; Gabrielyan, A.; Alvarado, C.; Williams, B.; Broomfield, B.; Duckworth, B.; Hockings, C.; Youssef, J.; Leong, E.; Morris, R.; Kueh, A.; Garnham, A.; Casanova, J.-L.; Boisson-Dupuis, S.; Babon, J.; Linossi, E.; Tate, M. D.; Groom, J. R.; Nicholson, S.

10.1101/2025.04.28.650977 — cell biology — Posted on 2025-04-29

301 Condensin I confers Stiffness and Centromeric Cohesion to Mitotic Chromosomes

Nielsen, C. F.; Witt, H.; Ridolfi, A.; Kempers, B.; Chameau, E. M. J.; van der Smagt, S.; Barisic, M.; Peterman, E. J. G.; Wuite, G. J. L.; Hickson, I. D.

10.1101/2025.04.29.651176 — cell biology — Posted on 2025-04-29

302 A genome-scale CRISPR deletion screen in Chinese Hamster Ovary cells reveals essential regions of the coding and non-coding genome

De Marco, F.; Sebastian, I. R.; Napoleone, A.; Molin, A.; Riedl, M.; Bydlinski, N.; Motheramgari, K.; Hussein, M.; Kramer, L.; Kelly, T.; Jostock, T.; Borth, N.

10.1101/2025.04.28.650989 — cell biology — Posted on 2025-04-29

303 Representational dynamics during extinction of fear memories in the human brain

Pacheco-Estefan, D.; Bouyeure, A.; Jacobs, G.; Fellner, M.- C.; Lehongre, K.; Lambrecq, V.; Frazzini, V.; Navarro, V.; Gunturkun, O.; Shen, L.; Yang, J.; Han, B.; Chen, Q.; Axmacher, N.

10.1101/2025.04.26.650560 — neuroscience — Posted on 2025-04-29

304 SnRK1.1 Coordinates Organ-Specific Growth-Defense Programs via Transcriptomic Rewiring in Arabidopsis thaliana

Kalachova, T.; Muller, K.; Lacek, J.; Pree, S.; Antonova, A.; Bondarenko, O.; Burketova, L.; Retzer, K.; Weckwerth, W.

10.1101/2025.04.25.650715 — plant biology — Posted on 2025-04-29

305 Wearable Assessment of Level and Uphill Running at Critical Intensity

Kirner, N. D. A.; Hoogkamer, W.

10.1101/2025.04.25.650654 — physiology — Posted on 2025-04-29

306 Cortical reactive microglia activate astrocytes, increasing neurodegeneration in human alcohol use disorder

Crews, F.; Qin, L.; Coleman, L.; Vetreno, R.

10.1101/2025.04.25.650687 — pharmacology and toxicology — Posted on 2025-04-29

307 Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment

Zhang, Y.; Xu, M.; Yuan, J.; Hu, Z.; Jiang, J.; Sun, Y.; Huang, J.; Wang, Y.; Wang, B.; Shen, J.; Long, M.; Fan, Y.; Montone, K. T.; Tanyi, J.; Kim, S. H.; Tavana, O.; Vonderheide, R. H.; Chan, H. M.; Domchek, S. M.; Hu, X.; Zhang, L.

10.1101/2024.05.21.595159 — cancer biology — Posted on 2025-04-29

308 Distinct druggable biological processes in early-onset prostate cancer

Schmidt, S.; Jarai, Z.; Larkeryd, A.; Ozer, B.; Karlsson, Q.; Campbell, J.; Merson, S.; Dennis, N.; Hazell, S.; Mitsopoulos, C.; Cooper, C.; ICGC-UK, T.; Consortium, T.; Russell, K.; Workman, P.; Eeles, R.; Al-Lazikani, B.

10.1101/2025.04.25.650707 — cancer biology — Posted on 2025-04-29

309 Overcoming effects of heterogeneous binding on BLI analysis

Sherer, N.; Cho, J.-H.

10.1101/2025.04.25.650696 — biophysics — Posted on 2025-04-29

310 Identification of the Best Filter-based Feature Selection Techniques for Microarray Datasets

Islam, A.; Bhadra, T.; Mali, K.; Giri, J.; Aurangzeb, K.; Budhathoki, R. K.; Mallik, S.

10.1101/2025.04.25.650719 — bioinformatics — Posted on 2025-04-29

311 Robotic performance is comparable to human operators for cell therapy manufacturing tasks

Sadhu, S.; Schmittlein, B.; Lares, A.; Nayak, S.; Uboldi, M.; Yu, Y.; Wang, J.; Zhang, W.; Bhanap, P. P.; Ji, Y.; Scheffler, A.; Wilson, J.; Welch, D.; Gkitsas-Long, N.; Retherford, A. J.; Melocchi, A.; Parietti, F.; Feldman, S. A.; Esensten, J. H.

10.1101/2025.04.25.650551 — bioengineering — Posted on 2025-04-29

312 Young Asian elephant calves show differentiated social relationships with conspecifics

Revathe, T.; Vidya, T. N. C.

10.1101/2025.04.27.650831 — animal behavior and cognition — Posted on 2025-04-29

313 Tulp3 quantitative alleles titrate requirements for viability, brain development, and kidney homeostasis but do not suppress Zfp423 mutations in mice.

McCoy, C. A.; Concepcion, D.; Mezody, M. G.; Lara, R. Z.; Deshpande, O.; Liang, C.; Long, R.; Hamilton, B. A.

10.1101/2025.04.25.650726 — genetics — Posted on 2025-04-29

314 Short-term gonadal cultures are sufficient for germline transmission in a songbird

Biegler, M. T.; Harter, E.; Sidhu, A. V.; Szialta, C.; Durham, G.; Tchernichovski, L.; Collier, P.; Luo, J.-D.; Wang, W.; MacIsaac, R.; Belay, K.; Carroll, T.; Keyte, A. L.; Jarvis, E. D.

10.1101/2025.04.25.650428 — developmental biology — Posted on 2025-04-29

315 Backpropagation through time training of an unrolled Hodgkin Huxley model for automatic conductance estimation

Li, Y.

10.1101/2025.04.27.650871 — neuroscience — Posted on 2025-04-29

316 Continuous theta-burst stimulation of the prefrontal cortex in the macaque monkey: no evidence for within-target inhibition or cross-hemisphere disinhibition of neural activity

Lehmann, S. J.; Corneil, B. D.

10.1101/2025.04.28.651079 — neuroscience — Posted on 2025-04-29

317 Brainstem sensing of multiple body signals during food consumption

Essner, R. A.; Ruda, K.; Choh, H. J.; Kucukdereli, H.; Amsalem, O.; Edelhaus, J.; Grodem, S.; Lensjo, K. K.; Lever, T. E.; Andermann, M. L.

10.1101/2025.04.28.651046 — neuroscience — Posted on 2025-04-29

318 Early visual experience elicits cellular and functional plasticity in the retina and alters behaviour

Reynolds, P.; Marchi, D.; Ling, Y. T.; Slangewal, K.; Capelle, M.; Chalakova, Z.; Bahl, A.; Hindges, R.

10.1101/2025.04.29.651180 — neuroscience — Posted on 2025-04-29

319 Achieving cell-type specific transduction with adeno-associated viral vectors in pigeons

Tuff, J. M.; Haselhuhn, K.; Surdin, T.; Herlitze, S.; Ziegler, M.; Guentuerkuen, O.; Rook, N.

10.1101/2025.04.29.651184 — neuroscience — Posted on 2025-04-29

320 PIBE: Parallel ion beam etching of sections collected on wafer for ultra large-scale connectomics

Ma, H.; Lv, Y.; Wang, M.; Zhao, Z.; Zhang, L.; Chang, S.; Liu, J.; Chen, B.; Dong, X.; Zhang, Y.; Guo, J.; Chen, H.; Zhai, H.; Li, L.; Chen, X.; Han, H.

10.1101/2025.04.25.650569 — neuroscience — Posted on 2025-04-29

321 Cardiac interoception impacts behavior and brain-wide neuronal dynamics

Herrera, K. J.; Zarghani-Shiraz, A.; Ahrens, M. B.; Engert, F.; Fishman, M. C.

10.1101/2025.04.25.650721 — neuroscience — Posted on 2025-04-29

322 Analysing the Role of KIN10 in Directional Root Growth Regulation in Arabidopsis thaliana

Retzer, K.; Garcia-Gonzalez, J.; Muller, K.; Lacek, J.; Pree, S.; Friedl, N.; Weckwerth, W.

10.1101/2025.04.25.650732 — plant biology — Posted on 2025-04-29

323 Probe-Free Multiplexed RPA Detection Via Single-Molecule Nanopore Sensing and Deep Learning Classification

Ahamed, M. A.; Khalid, M. A. U.; Politza, A. J.; Zaman, W. U.; Guan, W.

10.1101/2025.04.24.650542 — molecular biology — Posted on 2025-04-25

324 In-cell discovery and characterization of a non-canonical bacterial protein translocation-folding complex

Jensen, R. K.; Xue, L.; Marotta, F.; Somody, J. C.; Selkrig, J.; Lenz, S.; Rappsilber, J.; Savitski, M. M.; Kosinski, J.; Typas, A.; Zimmermann-Kogadeeva, M.; Bork, P.; Mahamid, J.

10.1101/2025.04.25.650208 — molecular biology — Posted on 2025-04-25

325 Deaminase-based RNA recording enables high throughput mutational profiling of protein-RNA interactions

Bakker, R. A.; Nicholson, O. B.; Park, H.; Xiao, Y.-L.; Tang, W.; Subramaniam, A. R.; Lapointe, C. P.

10.1101/2025.04.11.648485 — molecular biology — Posted on 2025-04-25

326 Sex-lethal is recruited to chromatin to promote neuronal tRNA synthesis in males through RNA Polymerase III regulation

Storer, F.; McClure, C. D.; Estacio Gomez, A.; Wong, T. L.; Minkley, L. J.; Southall, T. D.

10.1101/2025.04.25.650657 — molecular biology — Posted on 2025-04-25

327 eRNAkit: Expanding the Functional Atlas of human Enhancer RNAs Beyond the Nucleus

Benova, N.; Kuklinkova, R.; Eldahshoury, M. K.; Anene, C. A.

10.1101/2025.04.25.650683 — molecular biology — Posted on 2025-04-25

328 The spliceosome component U1-70k loads nascent transcripts onto FVE/SGS3 via co-condensation to embark on RNA silencing

Oh, T.; Liu, K.; Li, N.; Li, C.; Zhong, S.; Zhu, J.; Laubinger, S.; Zhang, X.

10.1101/2025.04.22.650084 — molecular biology — Posted on 2025-04-26

329 Separating anorexia-dependent and -independent effects in cancer cachexia

Liang, Y.; Kwon, Y.-Y.; Hui, S.

10.1101/2025.04.24.650538 — molecular biology — Posted on 2025-04-26

330 A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia

Lange, S. M.; Eisert, R. J.; Brown, A.

10.1101/2025.04.24.650332 — molecular biology — Posted on 2025-04-26

331 Protein-mediated stabilization and nicking of the non-template DNA strand dramatically affect R-loop formation in vitro

Holleman, E. T.; Catley, T.; Sereiva, T.; Hartono, S.; Pyne, A. L. B.; Chedin, F.

10.1101/2025.04.24.649451 — molecular biology — Posted on 2025-04-26

332 Suppression of nonsense mutations by small, cyclic peptides

Birkmose, N.; Bhat, S. Y.; Bhatthacharya, A.; Hansen, P. R.; Andersen, T. G.; Hunter, S.; Larsen, E. T.; Goldman, Y.; Cooperman, B. S.; Knudsen, C. R.

10.1101/2025.04.25.650553 — molecular biology — Posted on 2025-04-26

333 A drug combinational therapy consisting of toxin phospholipase A2 and metalloproteinase inhibitors provides preclinical protection against North American Crotalid snakebite envenoming

Dawson, C. A.; Marriott, A. E.; Crittenden, E.; Westhorpe, A.; Stars, E.; Edge, R. J.; Hall, S. R.; Menzies, S. K.; Clare, R. H.; Casewell, N. R.

10.1101/2025.04.25.648899 — molecular biology — Posted on 2025-04-26

334 Fluphenazine, an antipsychotic compound, ameliorates Alzheimer's disease by clearing amyloid beta accumulation in

Devare, M. N.; Le, V.; Chung, V.; Vu, T.; Kaeberlein, M.

10.1101/2025.04.24.650484 — molecular biology — Posted on 2025-04-26

335 Cellular and Molecular Resolution of Focal Segmental Glomerulosclerosis Recurrence in Human Allografts

Gallon, L.; Zubair, H.; Rousselle, T. V.; Shetty, A. C.; Azim, S.; Bardhi, E.; Forte, E.; Drachenberg, C. B.; Akalin, E.; Talwar, M.; Bromberg, J. S.; Maluf, D. G.; Mas, V. R.

10.1101/2025.04.24.650454 — molecular biology — Posted on 2025-04-26

336 Phage lysis protein LysM acts as a wedge to block MurJ conformational changes

Kohga, H.; Lertpreedakorn, N.; Miyazaki, R.; Wu, S.; Tanaka, H.; Takahashi, Y. S.; Hosoda, K.; Yoshikaie, K.; Kuruma, Y.; Shigematsu, H.; Mori, T.; Tsukazaki, T.

10.1101/2025.04.26.650401 — molecular biology — Posted on 2025-04-26

337 Identification of HIV Tat and NF-κB binding proteins associated with semen-derived extracellular vesicles

Okeoma, B. C.; Kaddour, H.; Naushad, W.; Paromov, V.; Chaudhary, A.; Noghero, A.; Stapleton, J. T.; Okeoma, C. M.

10.1101/2025.04.25.650599 — molecular biology — Posted on 2025-04-26

338 Single cell mapping of the human endometrium and first trimester decidua identifies distinct epithelial and stromal cell contributions to fertility

Burns, G. W.; Paul, E.; Persaud, M.; Zhao, Q.; Li, R.; Blackledge, K.; Garcia de Paredes, J.; Shukla, P.; Arora, R.; Chemerinski, A.; Douglas, N.

10.1101/2025.04.24.650488 — molecular biology — Posted on 2025-04-26

339 Trichostatin A Treatment Has Little Impact on Nuclear compartments in Cells Depleted of H3K9me, H3K27me3, and uH2A

Fukuda, K.; Shimura, C.; Shinkai, Y.

10.1101/2025.04.26.646718 — molecular biology — Posted on 2025-04-26

340 Characterization of a crustacean hyperglycemic hormone of the horsehair crab Erimacrus isenbeckii

Toyota, K.; Kajimoto, A.; Ando, Y.; Takeuchi, K.; Ohira, T.

10.1101/2025.04.26.650751 — molecular biology — Posted on 2025-04-26

341 mmu-miR-1291 Alleviates Oxidative Damage in Myocytes by Modulating the Process of Gene-Mediated Ubiquitination

Shen, J.; Bo, D.; Wang, Y.; Bai, Y.

10.1101/2025.04.25.649032 — molecular biology — Posted on 2025-04-27

342 Mouse Bio-behavioral Phenotyping Using a Digital Homecage Framework for Long-timescale, High-resolution, and Multi-factor Data Collection and Analytics

Ognjanovski, N.; Ghimire, A.; Hale, P.; Kim, D.; Cerda, I. H.; Goldiez, E.; Marino, S.; Green, A.; Fitzgerald, P.; Vijayakumar, P.; Kirca, D.; Tong, M.; Muscat, N.; Cook, M.; Knopf, K.; Tang, M.; Chen, Y.; Bueno-Junior, L. S.; Weston, R.; Liu, T.-Y.; Hartner, J.; Dinov, I.; Watson, B. O.

10.1101/2025.04.25.650637 — animal behavior and cognition — Posted on 2025-04-29

343 Endogenous CGRP activates NRF2 signaling via non-electrophilic mechanisms

Powell, K.; Wadolowski, S.; Tambo, W.; Chang, E. H.-Y.; Kim, D.; Varghese, A.; Sciubba, D.; al-Abed, Y.; Wang, P.; Li, C.

10.1101/2025.04.25.650677 — molecular biology — Posted on 2025-04-27

344 Pervanadate-induced oxidation relieves autoinhibition of SRC protein tyrosine kinase

Mulholland, K. E.; Bourguet, M.; Cheng, N.; Rahman, O.; Ezerina, D.; Daly, L. A.; Lai, T.; Casanova, S. A.; Creixell, P.; Eyers, C.; Eyers, P.; Messens, J.; Byrne, D.; Sharpe, H.

10.1101/2025.04.27.650842 — molecular biology — Posted on 2025-04-27

345 The WAC-downWAC domain in the yeast ISW2 nucleosome remodeling complex forms a structural module essential for ISW2 function but not cell viability

Singh, A. K.; Grunert, S. I.; Pfaller, L.; Mueller-Planitz, F.

10.1101/2025.04.27.650761 — molecular biology — Posted on 2025-04-27

346 Multiplexed Deep Visual Proteomics Unveils Spatial Heterogeneity and Rare Endocrine States in Human Adult Pancreatic Islets

Mardamshina, M.; Dorka, N.; Thielert, M.; Bjoerklund, F.; Navarro, F. B.; Casals, A. M.; Kovacs, F.; Fox, J. E. M.; Horvath, P.; Macdonald, P. E.; Mann, M.; Lundberg, E.

10.1101/2025.04.27.650857 — molecular biology — Posted on 2025-04-27

347 Embryonic stem cell factors DPPA2/4 facilitate a unique chromatin state in non-small cell lung cancer

Seneviratne, J. A.; Crisp, C. L.; Glancy, E.; Choy, N.; Tan, W.; Neve, M.; Stammers, M.; Wang, T.; Johnstone, R.; Kaur, A.; Fennell, K. A.; Burr, M.; Parker, B.; Shakeel, S.; Eckersley-Maslin, M.

10.1101/2025.04.27.650876 — molecular biology — Posted on 2025-04-27

348 Exercise Conditioning Enhances Insulin Sensitivity with Metabolic and Glycemic Control Driven by Hepatic Silencing of HMGB1 in Type 2 Diabetic Mice

Bravo, G. M.; Paramasivam, P.; Jacquez, Q.; Sandoval, G.; Beason, H.; Ramirez, E. B.; Chi, J.; Gu, H.; Magalhaes, F. D. C.; Alvidrez, R. I. M.

10.1101/2025.04.27.650052 — molecular biology — Posted on 2025-04-27

349 PLAMseq enables the proteo-genomic characterization of chromatin-associated proteins and protein interactions in a single experimental workflow.

Gonzalez-Vinceiro, L.; Espejo-Serrano, C.; Soler-Oliva, M. E.; Mateos-Martin, M. L.; Rico, D.; Gonzalez-Aguilera, C.; Gonzalez Prieto, R.

10.1101/2025.04.27.650851 — molecular biology — Posted on 2025-04-27

350 ADAR1 regulates alternative splicing through an RNA editing-independent mechanism.

Sagredo, E. A.; Karlstrom, V.; Blanco, A.; Moraga, P.; Vergara, M.; Jarvelin, A. I.; Visa, N.; Marcelain, K.; Castello, A.; Armisen, R.

10.1101/2025.03.12.642916 — molecular biology — Posted on 2025-04-28

351 Targeting Regulatory Factors Associated with the Drosophila Myc cis-Elements by Reporter Expression, Gel Shift Assay, and Mass Spectrometric Protein Identification

Kharazmi, J.; Brody, T.; Moshfegh, C.

10.1101/2025.04.04.647281 — molecular biology — Posted on 2025-04-28

352 Discovery and therapeutic exploitation of Master Regulatory miRNAs in Glioblastoma

Saha, S.; Zhang, Y.; Gibert, M. K.; Dube, C.; Hanif, F.; Mulcahy, E.; Bednarek, S.; Marcinkiewicz, P.; Wang, X.; Kwak, G.; Hudson, K.; Sun, Y.; Dinda, M.; Saha, T.; Guessous, F.; Cruickshanks, N.; Colon, R. R.; Dell'Olio, L. G.; Anbu, R.; Kefas, B.; Kumar, P.; Klibanov, A. L.; Schiff, D.; Suk, J. S.; Hanes, J.; Mata, J.; Hafner, M.; Abounader, R.

10.1101/2025.04.01.646663 — cancer biology — Posted on 2025-04-25

353 Bypass of Blocking Lesions by RNAPII Impairs the Transcriptional DNA Damage Response

Banuelos, C. P.; Caeiro, L. D.; Cingaram, P. R.; Beckedorff, F.; Morey, L.; Cortes, D. B.; Shiekhattar, R.; Verdun, R. E.

10.1101/2025.04.28.651040 — molecular biology — Posted on 2025-04-28

354 c-MYC can Form Phase Condensates via its DNA Binding Domain

Vijayakumar, U.; Choudhary, R.; Chng, W. J.; Fullwood, M. J.

10.1101/2025.04.22.650002 — cancer biology — Posted on 2025-04-25

355 Mapping Architecture of Protein complexes in Arabidopsis using XL-MS

Trinh, C. S.; Shrestha, R.; Conner, W. C.; Reyes, A. V.; Karunadasa, S. S.; Liu, G.; Hu, K.; Xu, S.-L.

10.1101/2025.04.28.651104 — molecular biology — Posted on 2025-04-28

356 PCSK9 dependent cholesterol acquisition and utilization underlies metastatic organ preference in pancreatic cancer.

Perera, R. M.; Rademaker, G.; Hernandez, G.; Dahal, S.; Miller-Phillips, L.; Li, A. L.; Luan, C.; Qiu, L.; Liegeois, M. A.; Wang, B.; Wen, K. W.; Kim, G. E.; Collisson, E. A.; Kruger, S. F.; Boeck, S.; Ormanns, S.; Guenther, M.; Heinemann, V.; Haas, M.; Yeh, J. J.; Zoncu, R.

10.1101/2025.04.22.649912 — cancer biology — Posted on 2025-04-25

357 A 36-base hairpin within lncRNA DRAIC, which is modulated by alternative splicing, interacts with the IKKα coiled-coil domain and inhibits NF-κB and tumor cell phenotypes

Hao, X.; Chen, Y.; Sahu, D.; Przanowska, R. K.; Aaiyas, M.; Weidmann, C. A.; Nardi, I.; Weeks, K. M.; Dutta, A.

10.1101/2024.12.23.629241 — molecular biology — Posted on 2025-04-29

358 Variation in Natural Infection Outcomes and Cancer Cell Release from Soft-Shell Clams (Mya arenaria) with Bivalve Transmissible Neoplasia

Giersch, R. M.; Sevigny, J. K.; Weinandt, S. A.; Mayo, C.; Garrett, F. E.; Tindbaek, K.; Yonemitsu, M. A.; Hart, S. F.; Metzger, M. J.

10.1101/2025.04.22.650102 — cancer biology — Posted on 2025-04-26

359 A comprehensive benchmark for multiple highly efficient base editors with broad targeting scope

Wang, X.; Cheng, X.; Li, Z.; Ma, S.; Zhang, H.; Chen, Z.; Yao, Y.; Li, Z.; Zhong, C.; Li, Y.; Zhang, Y.; Menon, V.; Chao, L.; Li, W.; Fei, T.

10.1101/2024.12.17.628899 — molecular biology — Posted on 2025-04-29

360 CREB5 promotes immunotherapy resistance via tumor-intrinsic collagenmatrix deposition

Tiwari, P.; Colvin, K. J.; Kim, S. Y.; Kammula, A. V.; Chinai, J. M.; Alfaiate, N.; Revach, O.-Y.; Kistler, E.; Heo, S.; Anderson, S.; Moyer, S. M.; Sun, Z.; Cicerchia, A. M.; Palin, C. A.; Vyas, M.; Chuong, C. L.; Talamas, J. A.; Sade-Feldman, M.; Freeman, S. S.; Boland, G. M.; Yates, K. B.; Hacohen, N.; Demehri, S. W.; Doench, J. G.; Jenkins, R. W.; Hahn, W. W.; Manguso, R. T.

10.1101/2025.04.22.649109 — cancer biology — Posted on 2025-04-26

361 Targeting mTORC2 in lung squamous cell carcinoma improves anti-tumor immunity through the PSGL-1-VISTA axis

Ngwa, V. M.; Hwang, Y.; Song, W.; Edwards, D. M.; Chen, J.

10.1101/2025.04.23.650229 — cancer biology — Posted on 2025-04-26

362 From Transcripts to Cells: Dissecting Sensitivity, Signal Contamination, and Specificity in Xenium Spatial Transcriptomics

Bilous, M.; Buszta, D.; Bac, J.; Kang, S.; Dong, Y. E.; Tissot, S.; Andre, S.; Alexandre-Gaveta, M.; Voize, C.; Peters, S.; Homicsko, K.; Gottardo, R.

10.1101/2025.04.23.649965 — cancer biology — Posted on 2025-04-26

363 The Role of c-Jun Signaling in Cytidine Analog-Induced Cell Death in Melanoma

Sensenbach, S.; Ngo, H. G.; Ghosh, S.; Karki, P.; Angardi, V.; Orman, M. A.

10.1101/2025.04.23.650054 — cancer biology — Posted on 2025-04-26

364 Modulating populational variance of methyl-guanine methyl transferase expression through miR-181d degradation: a novel mechanism of temozolomide resistance

Singh, G.; Singh, S.; Mohapatra, I.; Kim, S.; Sharma, M.; Akers, J.; Nguyen, T.; Wong, E.; Moreno, M. M.; Kokkoli, E.; Vasudevan, S.; Lawler, S. E.; El-Deiry, W. S.; Gokaslan, Z.; Chen, C. C.

10.1101/2025.04.22.650094 — cancer biology — Posted on 2025-04-26

365 Unique epigenomic signatures identify biologically significant subtypes of MDS and predict response to azacitidine

Yang, Q.; Torres-Martin, M.; Taguchi, M.; Brogi, A.; Casalin, I.; Ceneri, E.; Halene, S.; DeZern, A. E.; Griffiths, E. A.; Follo, M. Y.; Finelli, C.; Radich, J. P.; Rauh, M. J.; Bejar, R.; Sekeres, M. A.; Santini, V.; Figueroa, M. E.

10.1101/2025.04.23.650336 — cancer biology — Posted on 2025-04-26

366 (p)ppGpp-dependent activation of gene expression during nutrient limitation

Nagarajan, S. N.; Rosenthal, A. Z.; Dworkin, J.

10.1101/2025.04.25.650602 — microbiology — Posted on 2025-04-25

367 Niche Macrophages Recycle Iron to Tumor Cells and Foster Erythroblast Mimicry to Promote Bone Metastasis and Anemia

Han, Y.; Sarkar, H.; Xu, Z.; Darwin, S. L.-; Wei, Y.; Hang, X.; Liu, F.; Tran, K.; Wang, W.; Miller, J. M.; DeCoste, C. J.; Blohm, D. S.; Satcher, R. L.; Zhang, X. H.- F.; Kang, Y.

10.1101/2025.04.23.650120 — cancer biology — Posted on 2025-04-26

368 TlyA is a 23S and 16S 2'-O-methylcytidine methyltransferase important for ribosome assembly in Bacillus subtilis

Hibma, J. L.; Munson, L. M.; Jones, J. D.; Nye, T. M.; Koutmou, K. S.; Simmons, L. A.

10.1101/2025.04.21.649808 — microbiology — Posted on 2025-04-25

369 SNHG10 promote tumorigenesis via miR-150/VEGFA/EGFR/AKT/ERK/mTOR axis and gemcitabine resistance in PDAC

Pandya, G.; Singh, A.; Sourav, S.; Raju, S.; Kumari, R.; Sharma, R.; Goyal, V.; Das, B. C.; Sethi, G.; Pandey, A. K.; Pandita, D.; Motiani, R. K.; Garg, M.

10.1101/2025.04.24.650424 — cancer biology — Posted on 2025-04-26

370 Pseudomonas virulence factor SaxA detoxifies plant glucosinolate hydrolysis products, rescuing a commensal that suppresses virulence gene expression

Unger, K.; Ruiter, R.; Reichelt, M.; Gershenzon, J.; Agler, M. T.

10.1101/2025.04.25.650564 — microbiology — Posted on 2025-04-25

371 Neoantigens and Stochastic Fluctuations Regulate T Cell Proliferation in Primary and Metastatic Malignant Brain Tumors

Poudel, M.; Stewart, W. C.; Jayaprakash, C.; Das, J.

10.1101/2025.04.23.650340 — cancer biology — Posted on 2025-04-26

372 Lysine Decarboxylation aids in UPEC intracellular survival in the early stages of urinary tract infection

Reasoner, S. A.; Wiebe, M. A.; Bermudez, T.; Brannon, J. R.; Morales, G. H.; Guice, F.; Jennings, E. Q.; Rathmell, J.; Hadjifrangiskou, M.

10.1101/2025.04.25.650641 — microbiology — Posted on 2025-04-25

373 Capacity for compensatory cyclin D2 response confers trametinib resistance in canine mucosal melanoma

Wei, B.-R.; Verdi, V.; Zhang, S.; Mock, B. A.; Shive, H. R.; Simpson, R. M.

10.1101/2025.04.24.650512 — cancer biology — Posted on 2025-04-26

374 STRAIN-SPECIFIC VIRULENCE SIGNATURES OF CAMPYLOBACTER JEJUNI ASSOCIATED WITH WATERY VERSUS BLOODY DIARRHEA IN NEONATAL PIGLET MODEL

Bosquez, J. M.; Pascoe, B.; Parker, C. T.; Cooper, K. K.

10.1101/2025.04.25.650680 — microbiology — Posted on 2025-04-25

375 Dual targeting of RET and SRC synergizes in RET fusion-positive cancer cells

Son, J.; Rix, L. L. R.; Fang, B.; Welsh, E. A.; Bremer, N. V.; Foglizzo, V.; Roa, P.; Sigcha-Coello, N.; Haura, E.; Drilon, A.; Koomen, J. M.; Cocco, E.; Rix, U.

10.1101/2025.04.24.650465 — cancer biology — Posted on 2025-04-26

376 Flow cytometry-based isolation combined with ultra-sensitive proteomics of Salmonella-containing phagosomes reveals novel insights into host-pathogen interactions

Chatterjee, R.; Marin-Rubio, J. L.; Cianfanelli, F. R.; Frey, A. M.; Raymond, B. B. A.; Meng, M.; Dannoura, A.; Heunis, T.; Li, M.; Filby, A.; Trost, M.

10.1101/2025.04.25.650444 — microbiology — Posted on 2025-04-25

377 Stable isotope tracing in human plasma-like medium reveals metabolic and immune modulation of the glioblastoma microenvironment

Savani, M. R.; El Shami, M.; Gattie, L. C.; Smith, B. C.; Hicks, W. H.; Oken, S. S.; Zacharias, L. G.; Martin-Sandoval, M. S.; Montgomery, E. Y.; Xiao, Y.; Shi, D. D.; Rich, J. N.; Richardson, T. E.; Zinn, P. O.; Lega, B. C.; Mathews, T. P.; DeBerardinis, R. J.; McBrayer, S. K.; Abdullah, K. G.

10.1101/2023.05.29.542774 — cancer biology — Posted on 2025-04-26

378 The expanding avian influenza panzootic: skua die-off in Antarctica

Iervolino, M.; Günther, A.; Begeman, L.; Aguado, B.; Bestebroer, T. M.; Bellido-Martin, B.; Coerper, A.; Fornillo, M. V.; Fusaro, B.; Ibanez, A. E.; Leijten, L. M.; Lisovski, S.; Manez, M. B.; Reade, A.; van Run, P.; Soto, F.; Wallis, B.; Dewar, M.; Alcami, A.; Beer, M.; Vanstreels, R. E. T.; Kuiken, T.

10.1101/2025.04.25.650384 — microbiology — Posted on 2025-04-25

379 The landscape of structural variation in pediatric cancer

Greenhalgh, R.; Yang, W.; Brady, S. W.; Flasch, D. A.; Liu, Y.; Szlachta, K. A.; Tian, L.; Kolekar, P.; Wang, J.; Zhou, X.; Gerhard, D. S.; Ma, X.; Zhang, J.

10.1101/2025.04.24.650284 — cancer biology — Posted on 2025-04-26

380 Microfluidic Droplet-Assisted Single-Cell Raman Sorting for High-Throughput Screening of Functional Lignin-Degrading Microbes

Jia, T.; Zhang, M.; Chen, H.; Lu, L.; Wang, L.; Wang, Y.; Zheng, G.

10.1101/2025.04.25.650636 — microbiology — Posted on 2025-04-25

381 Novel biomarkers in mutation-specific gene profiles highlight the involvement of COL9A3 in cancer cell plasticity in uveal melanoma

Brosens, E.; van den Bosch, Q.; Verdijk, R.; van den Bosch, T.; Owens, S.; Kennedy, S.; Fadlelseed, H.; Kilic, E.

10.1101/2025.04.24.650445 — cancer biology — Posted on 2025-04-27

382 Evaluation of anti-noroviral compounds on human norovirus replication using 2D monolayers of human intestinal organoids

Hayashi, T.; Fujii, Y.; Hirano, J.; Kobayashi, S.; Murakami, K.

10.1101/2025.04.25.650600 — microbiology — Posted on 2025-04-25

383 Dual MYC and GSPT1 Protein Degrader for MYC-Driven Cancers

Nishida, Y.; Impedovo, V.; Ayoub, E.; Baran, N.; Scruggs, D. A.; Mizuno, H.; Khazaei, S.; Ostermann, L. B.; SIngh, S.; Bedoy, A.; Mak, P. Y.; Carter, B. Z.; Sugihara, E.; Takimoto, T.; Tong, Y.; Zhou, Q.; Yang, Z.; Yan, H.; Chen, D.; Maiti, A.; Sasaki, K.; Boettcher, S.; Haferlach, T.; Tiziani, S.; Ma, L.; Andreeff, M.

10.1101/2025.04.24.650490 — cancer biology — Posted on 2025-04-27

384 Globally prevalent Kelch13 mutations increase partial artemisinin resistance and fitness in Bangladeshi Plasmodium falciparum parasites

Nima, M. K.; Bhattacharyya, N.; Shoue, D.; Park, J.; Phru, C. S.; Sazed, S. A.; Kumar, S.; Alam, M. S.; Ferdig, M. T.; Mukherjee, A.

10.1101/2025.04.25.650672 — microbiology — Posted on 2025-04-25

385 Oral Intake of Deuterated Choline at Clinical Dose for Metabolic Imaging of Brain Tumors

Osoliniec, V. E.; Thomas, M. A.; de Graaf, R. A.; De Feyter, H. M.

10.1101/2025.04.24.650452 — cancer biology — Posted on 2025-04-27

386 Growth rates and Metabolic Traits Differentiate Campylobacter jejuni Strains by Diarrheal Manifestation

Bosquez, J. M.; Parker, C. T.; Pascoe, B.; Cooper, K. K.

10.1101/2025.04.24.650550 — microbiology — Posted on 2025-04-25

387 ADAR1 Regulates Lipid Remodeling to Dictate Ferroptosis Sensitivity

Kung, C.-P.; Terzich, N. D.; Ilagan, M. X. G.; Prinsen, M. J.; Kaushal, M.; Kladney, R. D.; Weber, J. H.; Mabry, A. R.; Torres, L. S.; Bramel, E. R.; Freeman, E. C.; Sabloak, T.; Ryu, S.; Weber, W. M.; Cottrell, K. A.; Maggi, L.; Shriver, L. P.; Patti, G. J.; Weber, J. D.

10.1101/2025.01.16.633410 — cancer biology — Posted on 2025-04-27

388 Bacterial diversity turnover estimates in a continental river system

Demeter, K.; Savio, D.; Kirschner, A.; Reischer, G. H.; Kolarevic, S.; Parajka, J.; Derx, J.; Jakwerth, S.; Wurzbacher, C.; Blaschke, A. P.; Mach, R. L.; Bloeschl, G.; Farnleitner, A. H.; Eiler, A.

10.1101/2025.04.25.650558 — microbiology — Posted on 2025-04-25

389 Tumor Landscape Analysis: An Ecologically Informed Framework to Understand Tumor Microenvironments

Cisneros, L.; Toruner, M. D.; Fernandez-Zapico, M. E.; Maley, C. C.; Carr, R. M.

10.1101/2025.04.22.646608 — cancer biology — Posted on 2025-04-27

390 Pfs48/45 nanobodies block Plasmodium falciparum transmission

Lyons, F.; Chmielewski, J.; Gabriela, M.; Chan, L.-J.; Tong, J.; Adair, A.; Zeglinski, K.; Gouil, Q.; Dietrich, M.; Tham, W.-H.

10.1101/2025.04.24.650534 — microbiology — Posted on 2025-04-25

391 APOE genotype and sex drive microbiome divergence after microbiome standardization in APOE-humanized mice

Aries Marchington, M.; Gasvoda, H.; Michelotti, M.; Rodriguez-Caro, F.; Gooman, A.; Perez, A.; Hensley-McBain, T.

10.1101/2025.04.25.650741 — microbiology — Posted on 2025-04-26

392 Inclusion of JNK-independent drugs within multi-agent chemotherapy improves response in relapsed high-risk neuroblastoma

Han, J. Z.; Phimmachanh, M.; Hastings, J. F.; Leong, K. H.; Ng, B. H.; Fontaine-Titley, A.; Cadell, A. L.; O'Donnell, Y. E.; Clearwater, M.; Kamili, A.; Haber, M.; Norris, M.; Timpson, P.; Trahair, T. N.; Fletcher, J. I.; Fey, D.; Kolch, W.; Latham, S. L.; Croucher, D. R.

10.1101/2025.04.26.650760 — cancer biology — Posted on 2025-04-27

393 Exploiting the CXCR3/CXCL10 pathway to override tumor immune suppression by enhancing immune trafficking and effector cell priming in head and neck squamous cell carcinoma

Shinn, C. K.; Saddawi-Konefka, R.; Salanga, C.; Schokrpur, S.; Gutkind, J. S. K.; Handel, T. M.

10.1101/2025.04.24.650529 — cancer biology — Posted on 2025-04-28

394 Antibiotic Resistance in Staphylococcus aureus: Effects of Quorum Sensing Inhibition and DNA Fragmentation

Kurup, S. S.; Taylor, P. K.; Assogba, B. D.; Adams, P. J.

10.1101/2025.04.26.649666 — microbiology — Posted on 2025-04-26

395 Fecal Microbial and Metabolic Signatures in VEO-IBD: Implications for Unique Pathophysiology

Kvitne, K. E.; Zuffa, S.; Charron-Lamoureux, V.; Mohanty, I.; Patan, A.; Mannochio-Russo, H.; Zemlin, J.; Burnett, L.; Zhang, L. S.; Cecala, M. C.; Ersoz, C.; Connelly, J. A.; Halasa, N.; Nicholson, M.; Dorrestein, P. C.; Tsunoda, S. M.; Markle, J.

10.1101/2025.04.26.650779 — microbiology — Posted on 2025-04-26

396 Multi-cellular phenotypic dynamics during the progression of breast tumors

Gsell, L.; Watson, S. S.; Sutevski, I.; Massara, M.; Soukup, K.; Eroglu, A.; Mold, J. E.; Joyce, J. A.; Hausser, J.

10.1101/2025.04.16.649085 — cancer biology — Posted on 2025-04-28

397 Antifungal biosynthesis by root-associated Streptomyces and Pseudomonas is elicited upon plant colonization

Tigani, W.; Du, C.; Elsayed, S. S.; Innocenti, P.; Carrion-Bravo, V.; Rimboi, I.; Martin, N. I.; Raaijmakers, J. M.; van Wezel, G. P.

10.1101/2025.04.26.650784 — microbiology — Posted on 2025-04-26

398 Single-cell transcriptomic analysis of HPV-related multiphenotypic sinonasal carcinoma uncovers MYB-HPV association

Wizel, A.; Spence, M. D. A.; Mints, M.; Britton, W.; Okolo, O.; Yu, V.; Cioffi, I.; Caruana, S.; Troob, S. H.; Faquin, W. C.; Lin, D. T.; Tirosh, I.; Puram, S. V.; Parikh, A. S.; Drier, Y.

10.1101/2025.04.21.649795 — cancer biology — Posted on 2025-04-28

399 Identification of Raptor and GLI1 as USP37 substrates highlight its context-specific function in medulloblastoma cells.

Singh, A.; Cheng, D.; Haltom, A.; Yang, Y.; Dobson, T.; Hatcher, R.; Rajaram, V.; Gopalakrishnan, V.

10.1101/2025.04.22.650057 — cancer biology — Posted on 2025-04-28

400 Metabolic and Population Profiles of Active Subseafloor Autotrophs in Young Oceanic Crust at Deep-Sea Hydrothermal Vents

Elkassas, S. M.; Fortunato, C. S.; Grim, S.; Butterfield, D. A.; Holden, J. F.; Vallino, J. J.; Algar, C.; Zeigler Allen, L.; Larson, B.; Proskurowski, G.; Reddington, E.; Stewart, L.; Topcuoglu, B.; Huber, J. A.

10.1101/2025.04.25.650746 — microbiology — Posted on 2025-04-27

401 Metabolic and Population Profiles of Active Subseafloor Autotrophs in Young Oceanic Crust at Deep-Sea Hydrothermal Vents

10.1101/2025.04.25.650746 — microbiology — Posted on 2025-04-27

402 Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment

Zhang, Y.; Xu, M.; Yuan, J.; Hu, Z.; Jiang, J.; Sun, Y.; Huang, J.; Wang, Y.; Wang, B.; Shen, J.; Long, M.; Fan, Y.; Montone, K. T.; Tanyi, J. L.; Kim, S. H.; Tavana, O.; Vonderheide, R. H.; Chan, H. M.; Domchek, S. M.; Hu, X.; Zhang, L.

10.1101/2024.05.21.595159 — cancer biology — Posted on 2025-04-28

403 Role of Thioredoxin Reductase (TrxB) in Oxidative Stress Response of Francisella tularensis Live Vaccine Strain

Higgs, M. G.; Ma, Z.; Centone, A.; Bakshi, C. S.; MALIK, M.

10.1101/2025.04.27.650861 — microbiology — Posted on 2025-04-27

404 Specific degrader for fusion oncokinase kills tumors and is augmented by bimodal degrader-siRNA

Shirani, M.; Bowie, R. S.; Tomasini, M.; Hook, R.; Ng, D.; Shebl, B.; Lyons, B.; Coffino, P.; Simon, S. M.

10.1101/2025.04.24.650501 — cancer biology — Posted on 2025-04-28

405 Phage biocontrol reduces the burden on plant immunity through suppression of bacterial virulence

Erdrich, S. H.; Zupunski, M.; Schurr, U.; Grossmann, G.; Frunzke, J.; Arsova, B.

10.1101/2025.04.26.650785 — microbiology — Posted on 2025-04-27

406 A microRNA-based Therapy against Human Medulloblastoma Validated in a Xenotransplant Model using Wild-Type Mouse Embryos

Spattini, C.; La Rosa, L.; Pereira, R. C.; Giantomasi, L.; Pelizzoli, R.; Tuntevski, K.; Battaglia, G.; Di Fonzo, A.; Armirotti, A.; De Pietri Tonelli, D.

10.1101/2025.04.25.650572 — cancer biology — Posted on 2025-04-28

407 Leveraging the subgenus category to address genus over-splitting exemplified with Prescottella and other recently proposed Mycobacteriales genera.

Val-Calvo, J.; Scortti, M.; Vazquez-Boland, J. A.

10.1101/2025.04.27.650868 — microbiology — Posted on 2025-04-27

408 Longitudinal single-cell RNA sequencing of a neuroendocrine transdifferentiation model reveals transcriptional reprogramming in treatment-induced neuroendocrine prostate cancer

Sar, F.; Chung, H. C.; Lin, Y.-Y.; Lin, D.; Morova, T.; Haegert, A.; Volik, S.; Bell, R.; LeBihan, S.; Ozturan, D.; Xue, H.; Dong, X.; Wu, R.; Kung, H.-J.; Gleave, M. E.; Lack, N. A.; Wang, Y.; Collins, C. C.

10.1101/2025.04.25.650369 — cancer biology — Posted on 2025-04-28

409 Circular 23S rRNA within archaeal ribosomes

Shi, L.-D.; Penev, P.; Nissley, A. J.; Nayak, D. D.; Sachdeva, R.; Cate, J. H. D.; Banfield, J.

10.1101/2025.04.27.650855 — microbiology — Posted on 2025-04-27

410 Adipocytes in tumour microenvironment promote chemoresistance in TNBC through oxysterols

Websdale, A.; Al-Hilali, Y.; Kim, B.; Williams, B. J.; Wastall, L.; Roberg-Larsen, H.; Hughes, T. A.; Cioccoloni, G.; Thorne, J. L.

10.1101/2025.04.24.650225 — cancer biology — Posted on 2025-04-28

411 Mechanisms of resistance to active state selective tri-complex RAS inhibitors

Sang, B.; Ye, L. F.; Hu, F.; Pourfarjam, Y.; Cuevas-Navarro, A.; Fan, S.; Fu, Z.; Washington, A.; Rodriguez, D. J.; Vides, A.; Kar, S.; Ahler, E.; Lin, K. K.; Hegde, A.; Smith, J. A.; Wolpin, B. M.; Punekar, S. R.; Spira, A. I.; Garrido-Laguna, I.; Hong, D. S.; Dar, A. C.; Yaeger, R.; Arbour, K. C.; Lito, P.

10.1101/2025.04.24.649345 — cancer biology — Posted on 2025-04-28

412 Comparative phenotypic, genomic and transcriptomic characterisation of two Salmonella Typhimurium strains for a first-in-human challenge model

Smith, C.; Bzami, A.; Zhu, X.; White, J. A.; Roa, N.; Suvarnapunya, A. E.; Smith, E.; Rydlova, A.; Varro, R.; Killidar, Z.; Luo, L.; Perez Sepulveda, B.; Gordon, M. A.; Cooke, G. S.; Choy, R. K. M.; Hinton, J. C. D.; Gibani, M. M.

10.1101/2025.04.24.650425 — microbiology — Posted on 2025-04-28

413 The Landscape of Prostate Tumour Methylation

Arbet, J.; Yamaguchi, T. N.; Shiah, Y.-J.; Hugh-White, R.; Wiggins, A.; Oh, J.; Gebo, T.; Foucal, A.; Lesurf, R.; Jung, C.-H.; Dang, R. M. A.; Agrawal, R.; Livingstone, J.; Salcedo, A.; Yao, C. Q.; Espiritu, S. M. G.; Houlahan, K. E.; Yousif, F.; Heisler, L. E.; Papenfuss, A. T.; Fraser, M.; Pope, B.; Kishan, A.; Berlin, A.; Chua, M. L.; Corcoran, N. M.; van der Kwast, T.; Hovens, C. M.; Bristow, R. G.; Boutros, P. C.

10.1101/2025.02.07.637178 — cancer biology — Posted on 2025-04-29

414 Bactericidal activity of ZnO nanoparticles-anti TB drugs combination towards H37Rv strain and multidrug-resistant isolates of Mycobacterium tuberculosis via SufB splicing inhibition

Ojha, D. K.; Mehra, A.; Rout, S. S.; Giri, S.; Nayak, S.

10.1101/2025.03.13.643114 — microbiology — Posted on 2025-04-28

415 Pancreatic cancer patient-derived organoids capture therapy response and tumor evolution

Gout, J.; Perkhofer, L.; Lindenmayer, J.; Resheq, Y. J.; Schwab, J. D.; Kraus, J. M.; Roger, E.; Srinivasan, D.; Zimmer, E.; Mayer, B.; Marienfeld, R.; Gaisa, N. T.; Kühlwein, J. K.; Hänle, M.; Ettrich, T. J.; Danzer, K. M.; Beutel, A. K.; Kong, B.; Michalski, C.; Mihaljevic, A. L.; Rahbari, N. N.; Kornmann, M.; Kestler, H. A.; Seufferlein, T.; Kleger, A.

10.1101/2025.04.24.650216 — cancer biology — Posted on 2025-04-29

416 A horizontally acquired cyclic di-GMP phosphodiesterase regulated by zinc and quorum sensing

Anandhi Rangarajan, A.; Ok, K.; Malleck, M.; Ferrell, M.; O'Halloran, T.; Waters, C. M.

10.1101/2025.04.25.650742 — microbiology — Posted on 2025-04-28

417 A nuclear branched-chain amino acid catabolism pathway controls histone propionylation in pancreatic cancer

Demetriadou, C.; Noji, M.; Good, A. L.; Mitchell-Velasquez, E.; Venkatesh, S.; Kantner, D. S.; Pennise, J.; Costa-Pinheiro, P.; Pinheiro, L. V.; Harada, T.; Nguyen, P. T. T.; Chatoff, A.; Megill, E.; Crispim, C. V. D. S.; Marcinkiewicz, M. M.; Meier, J. L.; Arany, Z.; Asangani, I.; Furth, E. E.; Stanger, B. Z.; Snyder, N. W.; Wellen, K. E.

10.1101/2025.04.23.650241 — cancer biology — Posted on 2025-04-29

418 Targeted metagenomics using probe capture detect a larger diversity of nitrogen and methane cycling genes in complex microbial communities than traditional metagenomics

Siljanen, H. M. P.; Manoharan, L.; Hilts, A. S.; Bagnoud, A.; Alves, R. J. E.; Jones, C. M.; Kerou, M.; Sousa, F. L.; Hallin, S.; Biasi, C.; Schleper, C.

10.1101/2022.11.04.515048 — microbiology — Posted on 2025-04-28

419 Oncogene SETDB1s Dual Role in Endometrial Cancer: Driving Tumor Progression and Immune Escape

Salari, K.; Hao, J.; Jilek, R.; Wells, M.; Li, T.; Johnson, E.; Meng, W.; Zibble, E.; Allen, A.; Gilbert, J.; McLerran, R.; Schuett, E.; Oliva, C.; Griguer, C. E.; Meyerholz, D. K.; Yates, M.; Keen, H. L.; Meng, X.; Xiong, Y.; Li, B.; Yang, S.

10.1101/2025.04.23.650291 — cancer biology — Posted on 2025-04-29

420 The infection cycle of the haloarchaeal virus HFTV1 is tightly regulated and strongly inhibits motility of its host

Schwarzer, S.; Bäcker, L. E.; Nijland, J. G.; Hayani Aji, I.; de Jong, A.; Moraru, C.; Steglich, C.; Quax, T. E.

10.1101/2025.04.24.650469 — microbiology — Posted on 2025-04-28

421 Glutamine transporters regulate prostate cancer radiosensitivity through NUPR1-mediated stress response

Kahya, U.; Lukiyanchuk, V.; Gorodetska, I.; Weigel, M. M.; Köseer, A. S.; Alkan, B.; Savic, D.; Linge, A.; Löck, S.; Peitzsch, M.; Skvortsova, I.-I.; Krause, M.; Dubrovska, A.

10.1101/2025.04.22.650063 — cancer biology — Posted on 2025-04-29

422 The antifungal and other bioactive properties of the volatilome of Streptomyces scabiei

Stulanovic, N.; Bensaada, D.; Belde, L.; Adam, D.; Hanikenne, M.; Focant, J.-F.; Stefanuto, P.-H.; Rigali, S.

10.1101/2025.04.24.650436 — microbiology — Posted on 2025-04-28

423 Interrupting Elmsan1 repression of nuclear Acetyl-CoA production therapeutically reprograms cancer cells

10.1101/2025.04.25.650293 — cancer biology — Posted on 2025-04-29

424 CASTOR1: A Novel Tumor Suppressor Linking mTORC1 and KRAS Pathways in Tumorigenesis and Resistance to KRAS-Targeted Therapies in Non-Small Cell Lung Cancer

Wang, X.; Ding, L.; Sun, S.; Loo, S. K.; Chen, L.; Li, T.; Wang, M.-T.; Pennathur, A.; Huang, Y.; Gao, S.-J.

10.1101/2025.04.23.650349 — cancer biology — Posted on 2025-04-29

425 The microbiome interacts with the circadian clock and dietary composition to regulate metabolite cycling in the Drosophila gut

Zhang, Y.; Noya, S. B.; Li, Y.; chao, F. J.; Sehgal, A.

10.1101/2024.02.29.582770 — microbiology — Posted on 2025-04-28

426 The anti-metabolite KAT/3BP has in vitro and in vivo anti-tumor activity in lymphoma models

Tarantelli, C.; Spriano, F.; Civanelli, E.; Aresu, L.; Risi, G.; Cannas, E.; Kayali, O.; Cascione, L.; Arribas, A. J.; Stathis, A.; Ko, Y. H.; Bertoni, F.

10.1101/2025.04.23.650181 — cancer biology — Posted on 2025-04-29

427 Multiplexed PCR to measure in situ growth rates of uropathogenic E. coli during experimental urinary tract infection.

Paudel, S.; Severin, G. B.; Pirani, A.; Anderson, M. T.; Snitkin, E. S.; Mobley, H. L. T.

10.1101/2024.11.21.624689 — microbiology — Posted on 2025-04-28

428 A light-induced microprotein triggers regulated intramembrane proteolysis to promote photo sensing in a pathogenic bacterium.

Manias, D.; Winkelman, J. D.; Chen, G.; Mukherjee, S.

10.1101/2025.04.28.651061 — microbiology — Posted on 2025-04-28

429 Towards robust machine olfaction: debiasing GC-MS data enhances prostate cancer diagnosis from urine volatiles

Rotteveel, A.; Lee, W.-Y.; Kountouri, Z.; Stefanou, N.; Kivell, H.; Gluck, C.; Zhang, S.; Mershin, A.

10.1101/2024.11.19.624273 — cancer biology — Posted on 2025-04-29

430 Generation of a recombinant mimivirus by direct transfection of a PCR amplicon

Hikida, H.; Ogata, H.

10.1101/2025.04.28.651011 — microbiology — Posted on 2025-04-28

431 Inulin reduces Ralstonia invasion by promoting cooperation between Lysinibacillus sphaericus and Pseudoarthrobacter spp.

Yan, T.; Guan, Y.; Mei, X.; Zhang, Z.; Zhu, T.; Gao, Y.; Xu, Y.; Shen, Q.; Wei, Z.; Yang, T.

10.1101/2025.04.28.650914 — microbiology — Posted on 2025-04-28

432 Microbiome dynamics associated with the infection of grey field slugs by the biocontrol nematode Phasmarhabditis hermaphrodita

Ha, A. D.; Howe, D. K.; Colton, A. J.; McDonnell, R. J.; Denver, D.

10.1101/2025.04.27.650856 — microbiology — Posted on 2025-04-28

433 Microbial model communities reveal widespread auxotrophies in abundant bacteria

Pacheco-Valenciana, A.; Tausch, A.; Dharamshi, J. E.; Bergland, F.; Delgado Zambrano, L. F.; Rodriguez-Gijon, A.; Andersson, A. F.; Garcia, S. L.

10.1101/2025.04.28.650956 — microbiology — Posted on 2025-04-28

434 Global lessons from antibiotic resistance: metformin-hydrolyzing genes in transposable elements, a new threat for type II diabetic patients?

Vo, T.; Merhej, V.; Isber, C.; pontarotti, P.; Bittar, F.; Rolain, J.-M.

10.1101/2025.04.28.651035 — microbiology — Posted on 2025-04-28

435 Genetic mutations disrupt the coordinated mode of tyrosinase's intra-melanosomal domain.

Toay, S.; Sergeev, Y. V.

10.1101/2025.04.21.649833 — biophysics — Posted on 2025-04-25

436 Human cytomegalovirus triggered necroptosis is suppressed by sequestration of MLKL in the nucleus of infected monocytes

Geiler, B. W.; Moradpour, S.; Chauder, B. B.; Akter, D.; Chan, G. C.

10.1101/2025.04.28.651015 — microbiology — Posted on 2025-04-28

437 An Order of Magnitude Signal-to-Noise Improvement of Magnetic Resonance Spectra using a Segmented-Overlap Fourier-Filtering and Averaging (SOFFA) Approach.

Sidabras, J. W.

10.1101/2025.04.21.649794 — biophysics — Posted on 2025-04-25

438 Mechanism of bacterial outer membrane exchange revealed by quantitative microscopy

Topo, E. J.; Basurto De Santiago, C.; Cao, P.; Wall, D.; Nan, B.

10.1101/2025.04.25.650704 — microbiology — Posted on 2025-04-28

439 Volatile anaesthetics modulate voltage-gated sodium channel function at a site critical for gating

Hollingworth, D.; Herold, K. F.; Kelly, G.; Mykhaylyk, V. B.; Zhang, D.; Wallace, B. A.; Hemmings, H. C.

10.1101/2024.11.04.621342 — biophysics — Posted on 2025-04-25

440 A Multi-Organ Murine Metabolomics Atlas Reveals Molecular Dysregulations in Alzheimer's Disease

Zuffa, S.; Allaband, C.; Charron-Lamoureux, V.; Caraballo-Rodriguez, A. M.; Patan, A.; Mohanty, I.; Agongo, J.; Bostick, J. W.; Connerly, T.; Thron, T.; Needham, B.; de Castro Fonseca, M.; Salido, R.; Hansen, L.; Tubb, H.; Cao, J.; Kalecky, K.; Bottiglieri, T.; MahmoudianDehkordi, S.; Schimmel, L.; Kueider-Paisley, A.; Graham, S.; Siegel, D.; Wang, M.; Knight, R.; Kaddurah-Daouk, R.; Dorrestein, P. C.; Mazmanian, S.

10.1101/2025.04.28.651123 — microbiology — Posted on 2025-04-28

441 Aligned collagen fibers drive distinct traction force signatures to regulate contact guidance

Niraula, G.; Foroozandehfar, A.; Namanda, F. R.; Schneider, I.

10.1101/2025.04.22.650031 — biophysics — Posted on 2025-04-26

442 Mapping a Toxoplasma gondii interactome by crosslinking mass spectrometry and machine learning

Tomita, T.; Weyer, E.; Guevara, R.; Sidoli, S.; Aguilan, J.; Weiss, L. M.

10.1101/2025.04.28.651050 — microbiology — Posted on 2025-04-28

443 High-throughput discovery of transmembrane helix dimers from human single-pass membrane proteins with TOXGREEN sort-seq

Anderson, S. M.; Choi, J.; Cushman, E. M.; Leander, M.; Raman, S.; Senes, A.

10.1101/2025.04.22.650048 — biophysics — Posted on 2025-04-26

444 Atypical collective oscillatory activity in cardiac tissue uncovered by optogenetics

Teplenin, A. S.; Kudryashova, N. N.; Majumder, R.; de Vries, A. A. F.; Panfilov, A. V.; Pijnappels, D. A.; De Coster, T.

10.1101/2025.04.22.650000 — biophysics — Posted on 2025-04-26

445 A chromosome-scale genome assembly of the flax rust fungus reveals the two unusually large effector proteins, AvrM3 and AvrN

Sperschneider, J.; Chen, J.; Anderson, C.; Morin, E.; Zhang, X.; Lewis, D.; Henningsen, E.; Grigoriev, I. V.; Rathjen, J.; Jones, D.; Duplessis, S.; Dodds, P.

10.1101/2025.04.28.651126 — microbiology — Posted on 2025-04-28

446 Putting a lid on it: The N-terminal helix of Arf1 inhibits switching via stabilization of the overall native state

Peters, E. V. A.; Koduru, T.; Hantman, N. A.; McCallum, S. A.; Huang, Q.; Cherfils, J.; Royer, C. A.

10.1101/2025.04.22.650101 — biophysics — Posted on 2025-04-26

447 Interleukin-27 is antiviral at the maternal-fetal interface.

Merlino, M.; Barksdale, B.; Negatu, S. G.; Clements, R. L.; Miller-Ensminger, T.; Lopez, A. H.; Mani, S.; Mainigi, M.; Hunter, C.; Jurado, K.

10.1101/2025.04.28.651113 — microbiology — Posted on 2025-04-28

448 Structural basis for proton inhibition of the two-pore domain K+ channel TASK-1

Docter, T.; Reid, M. S.; Lee, N. S.; Brohawn, S. G.

10.1101/2025.04.23.650279 — biophysics — Posted on 2025-04-26

449 Could microalgae serve as an alternative to replace unsustainable palm oil?

Sterbova, K. x.; Bisova, K. x.; Manoel, J. A. C.; Masojidek, J. x.

10.1101/2025.04.28.651004 — microbiology — Posted on 2025-04-28

450 Genome-wide modeling of DNA replication in space and time confirms the emergence of replication specific patterns in vivo in eukaryotes

D'Asaro, D.; Arbona, J.-M.; Piveteau, V.; Piazza, A.; Vaillant, C.; Jost, D.

10.1101/2025.04.23.650322 — biophysics — Posted on 2025-04-26

451 Horizontal transfer of a 180-kbp genomic fraction among the largest viral genomes

Hikida, H.; Zhang, R.; Chen, J.; Okazaki, Y.; Ogata, H.

10.1101/2025.04.28.650931 — microbiology — Posted on 2025-04-28

452 Structural, Thermodynamic, and Dynamic Descriptors for Differential Mechanism of HIF-2 Activity Modulators

Punia, R.; Goel, G.

10.1101/2025.04.23.650354 — biophysics — Posted on 2025-04-26

453 Antiviral activity of the non-steroidal anti-inflammatory drug indomethacin against Respiratory Syncytial Virus

Tramontozzi, C.; Riccio, A.; La Frazia, S.; Svicher, V.; Santoro, M. G.

10.1101/2025.04.28.650844 — microbiology — Posted on 2025-04-28

454 Deep Learning-Based 3D Leukocyte Differentiation Using Label-Free Higher Harmonic Generation Microscopy

Zhou, M.; Gonzalez, P. J.; Dekker, T.; Zhang, S.; Boers, L. S.; van den Heuvel, H. B.; Dijkhuis, A.; Simons, I. A.; Duitman, J. W. W.; Groot, M. L.

10.1101/2025.04.24.650417 — biophysics — Posted on 2025-04-26

455 Genome sequencing and physiological characterization of three Neoarthrinium moseri strains

Hochenegger, N. J.; Vignolle, G. A.; Schmal, M.; Mach, R. L.; Mach-Aigner, A. R.; Rahimi, M. J.; Chan, C. M.; Cai, F. M.; Druzhinina, I. S.; Zimmermann, C.

10.1101/2025.04.28.650913 — microbiology — Posted on 2025-04-28

456 High-throughput discovery of transmembrane helix dimers from human single-pass membrane proteins with TOXGREEN sort-seq

Anderson, S. M.; Choi, J.; Cushman, E. M.; Leander, M.; Raman, S.; Senes, A.

10.1101/2025.04.22.650048 — biophysics — Posted on 2025-04-26

457 Intracellular Acinetobacter baumannii Acts as a Reservoir in Lung Infection via a 'Persist and Resist' Strategy

Janet-Maitre, M.; Di Venanzio, G.; Jackson-Litteken, C. D.; Scott, N. E.; Feldman, M. F.

10.1101/2025.04.28.651116 — microbiology — Posted on 2025-04-28

458 Boltz-1: Democratizing Biomolecular Interaction Modeling

Wohlwend, J.; Corso, G.; Passaro, S.; Getz, N.; Reveiz, M.; Leidal, K.; Swiderski, W.; Atkinson, L.; Portnoi, T.; Chinn, I.; Silterra, J.; Jaakkola, T.; Barzilay, R.

10.1101/2024.11.19.624167 — biophysics — Posted on 2025-04-26

459 Bactericidal Membrane Attack Complex formation initiates at the new pole of E. coli

van 't Wout, M. F. L.; Hauser, F.; Holzapfel, P. I. P.; Bardoel, B. W.; de Haas, C. J. C.; Jacak, J.; Rooijakkers, S. H. M.; Heesterbeek, D. A. C.

10.1101/2025.04.25.650575 — microbiology — Posted on 2025-04-29

460 Quantitative pharmacology methods for bispecific T cell engagers

Sadeghi, M.; Kareva, I.; Pogudin, G.; Sontag, E. D.

10.1101/2025.04.23.650214 — systems biology — Posted on 2025-04-26

461 Proportional modulation of proliferation and motility under 2D compressive stress depends on mesenchymal phenotype

Ben Meriem, Z.; Meksassi, M. B.; Denais, C.; Guillermet-Guibert, J.; Delarue, M.

10.1101/2025.04.24.650079 — biophysics — Posted on 2025-04-26

462 Organ-specific filtering by abiotic and biotic environmental factors shapes distinct yet overlapping microbial communities across Lotus corniculatus roots, shoots, flowers, and seeds

Lutap, K.; Bossdorf, O.; Kemen, E.

10.1101/2025.04.25.650623 — microbiology — Posted on 2025-04-29

463 Spatial μProBe: a correlative multimodal imaging approach for spatial profiling of biological micro-environments

C. Marques, F.; Mathavan, N.; Ohs, N.; Goenczoel, C.; J. Kendall, J.; Singh, A.; Yilmaz, D.; Kuhn, G. A.; A. Schulte, F.; Wehrle, E.; Müller, R.

10.1101/2025.04.23.650252 — systems biology — Posted on 2025-04-26

464 Recognition of unique cell surface glycopolymers by diversified lectin domains specifies umbrella toxin targeting

Zhao, Q.; Vlach, J.; Park, Y.-J.; Tan, Y.; Bertolli, S. K.; Srinivas, P.; Liao, P.; Fitzpatrick, C. R.; Dangl, J. L.; Azadi, P.; DiMaio, F.; Peterson, S. B.; Zhang, D.; Veesler, D.; Mougous, J. D.

10.1101/2025.04.24.650519 — microbiology — Posted on 2025-04-29

465 Coral anthozoan-specific opsins employ a novel chloride counterion for spectral tuning

Sakai, Y.; Sen, S.; Sugihara, T.; Kakeyama, Y.; Iwasaki, M.; Schertler, G.; Deupi, X.; Koyanagi, M.; Terakita, A.

10.1101/2024.12.12.628111 — biophysics — Posted on 2025-04-27

466 On the Impact of Smoking on The Oral-brain Axis: The Microbiome-Metabolism-Brain Interactions

Ulyah, S. M.; Savvopoulos, S. V.; Albataineh, M. T.; Jelinek, H. F.; Hatzikirou, H.

10.1101/2025.04.23.650308 — systems biology — Posted on 2025-04-26

467 Plant host identity drives Andropogon gerardii rhizobiome assembly strategies under increasing abiotic stress

Vogt, B.; Kazarina, A.; Sytsma, J.; Adams, B.; Rodela, L.; Clouse, D.; Keller, R.; Thompson, D.; Winters, H.; Wagner, M.; Jumpponen, A.; Johnson, L.; Lee, S. T. M.

10.1101/2025.04.12.648431 — microbiology — Posted on 2025-04-29

468 Cryo-EM reveals the structural heterogeneity and conformational flexibility of multidrug efflux pumps MdtB and MdtF

Padmanabhan, S.; Rencilin, C. F.; Biswas, R.; Dutta, S.

10.1101/2025.04.25.650598 — biophysics — Posted on 2025-04-27

469 Metabolites associated with type 2 diabetes and Alzheimer's disease trigger differential intracellular signaling responses in mouse primary neurons

Ball, B. K.; Kuhn, M. K.; Fleeman Bechtel, R. M.; Proctor, E. A.; Brubaker, D. K.

10.1101/2025.04.23.650328 — systems biology — Posted on 2025-04-26

470 Chemical propulsion of hemozoin crystal motion in malaria parasites

Hastings, E. M.; Skora, T.; Carney, K. R.; Fu, H. C.; Bidone, T. C.; Sigala, P. A.

10.1101/2025.04.25.650681 — biophysics — Posted on 2025-04-27

471 Myosin light chain 3 serves as a receptor for nervous necrosis virus entry into host cells via the macropinocytosis pathway

Yao, L.; Zhang, W.; Yang, X.; Yi, M.; Jia, K.

10.1101/2024.10.17.618790 — microbiology — Posted on 2025-04-29

472 A Hit Prioritization Strategy for Compound Library Screening Using LiP-MS and Molecular Dynamics Simulations Applied to KRas G12D Inhibitors

Absar, F.; Novy, B. C.; Nagy, E.; Petrotchenko, E. V.; Popov, K. I.; Cross, J. B.; Thapar, R.; Borchers, C. H.

10.1101/2025.04.22.650081 — biophysics — Posted on 2025-04-28

473 Mass spectrometry-based quantification of proteins and post-translational modifications in dried blood: longitudinal sampling of patients with sepsis in Tanzania

Foster, M. W.; McMahon, T. J.; Ngocho, J. S.; Kipengele, A. H.; Violette, M.; Chen, Y.; Madut, D. B.; Plumb, R. S.; Wong, A. I.; Chen, L.; Lee, G. M.; Sakasaka, P. A.; Mmbaga, B. T.; Crump, J. A.; McClain, M. T.; Woods, C. W.; Maro, V. P.; Rubach, M. P.

10.1101/2025.04.22.650109 — systems biology — Posted on 2025-04-26

474 Mechanism of bacterial outer membrane exchange revealed by quantitative microscopy

Topo, E. J.; De Santiago, C. B.; Cao, P.; Wall, D.; Nan, B.

10.1101/2025.04.25.650704 — microbiology — Posted on 2025-04-29

475 Deep dynamical models of single-cell multiomic velocities predict loss-of-function and rescue perturbations in B cells

Karbalayghareh, A.; Barisic, D.; Chin, C. R.; Melnick, A.; Leslie, C. S.

10.1101/2025.04.24.650458 — systems biology — Posted on 2025-04-26

476 Characterization of the KRas G12D-inhibitor interactions by HDX-MS and molecular dynamics simulations

Petrotchenko, E. V.; Novy, B. C.; Nagy, E.; Popov, K. I.; Cross, J. B.; Thapar, R.; Borchers, C. H.

10.1101/2025.04.22.650091 — biophysics — Posted on 2025-04-28

477 Gut bacteria degrade purines via the 2,8-dioxopurine pathway

Liu, Y.; Zhou, Z.; Bryce Jarman, J.; Chen, H.; Miranda-Velez, M.; Terkeltaub, R.; Dodd, D.

10.1101/2025.04.24.650524 — microbiology — Posted on 2025-04-29

478 A surrogate workflow for virtual population development: designing an amenable proxy for a hypothesis-test inspired nonlinear goodness-of-fit

Huang, L.; Chen, Y.; Suryawanshi, S.; Molavi, A.; Sison, E.; Schmidt, B. J.

10.1101/2025.04.26.649406 — systems biology — Posted on 2025-04-27

479 A novel shared mechanism for Bacteroidota protein transport and gliding motility

Liu, X.; Avramova, M.; Deme, J. C.; Jones, R. L.; Lundgren, C. A.; Lea, S. M.; Berks, B. C.

10.1101/2025.03.12.642685 — microbiology — Posted on 2025-04-29

480 Correlations among hydrogen bond fluctuations in the apo state are enough to reveal allosteric networks in proteins

Sarkar, S.; Dhibar, S.; Jana, B.

10.1101/2025.04.23.650155 — biophysics — Posted on 2025-04-28

481 Delaying Cancer Progression by Integrating Toxicity Constraints in a Model of Adaptive Therapy

Gevertz, J. L.; Jain, H. V.; Kareva, I.; Wilkie, K. P.; Brown, J.; Huang, Y. P.; Sontag, E.; Vinogradov, V.; Davies, M.

10.1101/2025.04.24.650205 — systems biology — Posted on 2025-04-27

482 Multivalent interaction induces phase separation and formation of more toxic aggregates of α-syn in a yeast model of Parkinsons disease

Jain, R.; Sharavanakkumar, S.; Chattopadhyay, K.

10.1101/2025.04.14.648683 — biophysics — Posted on 2025-04-28

483 Bulk-level maps of pioneer factor binding dynamics during Drosophila maternal-to-zygotic transition

Dima, S. S.; Reeves, G. T.

10.1101/2024.09.06.611749 — systems biology — Posted on 2025-04-27

484 Evolution of a fuzzy ribonucleoprotein complex in viral assembly

Zhao, H.; Li, T.; Hassan, S. A.; Nguyen, A.; Datta, S. A.; Zhang, G.; Trent, C.; Czaja, A. M.; Wu, D.; Aronova, M. A.; Lai, K. K.; Piszczek, G.; Leapman, R. D.; Yewdell, J. W.; Schuck, P.

10.1101/2025.04.26.650775 — biophysics — Posted on 2025-04-28

485 Mass spectrometry-based quantification of proteins and post-translational modifications in dried blood: longitudinal sampling of patients with sepsis in Tanzania

10.1101/2025.04.22.650109 — systems biology — Posted on 2025-04-28

486 Polyphosphate Discriminates Protein Conformational Ensembles More Efficiently than DNA Promoting Diverse Assembly and Maturation Behaviors

Goyal, S.; Rajendran, D.; Mani, A. K.; Naganathan, A. N.

10.1101/2024.10.21.619443 — biophysics — Posted on 2025-04-28

487 A mathematical model for ketosis-prone diabetes suggests the existence of multiple pancreatic β-cell inactivation mechanisms

Ridout, S. A.; Vellanki, P.; Nemenman, I.

10.1101/2024.06.04.597343 — systems biology — Posted on 2025-04-28

488 Interpretable Protein-DNA Interactions Captured by Structure-Sequence Optimization

Zhang, Y.; Silvernail, I.; Lin, Z.; Lin, X.

10.1101/2024.05.26.595895 — biophysics — Posted on 2025-04-28

489 Inside-Out: Modeling the link between Zika virus viral dynamics within hosts and transmission to vectors across host species and virus strains

Cecilia, H.; Althouse, B. M.; Azar, S. R.; Rossi, S. L.; Vasilakis, N.; Hanley, K. A.

10.1101/2025.04.23.650178 — systems biology — Posted on 2025-04-29

490 CryoDRGN-AI: Neural ab initio reconstruction of challenging cryo-EM and cryo-ET datasets

Levy, A.; Raghu, R.; Feathers, J. R.; Grzadkowski, M.; Poitevin, F.; Vallese, F.; Clarke, O. B.; Wetzstein, G.; Zhong, E. D.

10.1101/2024.05.30.596729 — biophysics — Posted on 2025-04-28

491 Super-resolving particle diffusion heterogeneity in porous hydrogels via high-speed 3D active-feedback single-particle tracking microscopy

Lin, Y.; Lin, H.; Welsher, K.

10.1101/2025.03.13.643103 — biophysics — Posted on 2025-04-28

492 Mass spectrometry-based quantification of proteins and post-translational modifications in dried blood: longitudinal sampling of patients with sepsis in Tanzania

10.1101/2025.04.22.650109 — systems biology — Posted on 2025-04-29

493 Electric Field Induces Dewetting Transitions in Amphiphilic Crystalline Domains of Chitosan-Based Hydrogels

Romany, A.; Payne, G. F.; Shen, J.

10.1101/2025.04.25.650622 — biophysics — Posted on 2025-04-28

494 Preclinical Proof of Concept for a personalized SNAPTM-TIL (Specific Neo-Antigen Peptides -TIL) therapy platform

Halder, T. G.; Kelley, E.; Soria-Bustos, J.; Thode, T.; NG, S.; Bargenquast, T.; Weston, A.; Rodriguez del Villar, R.; Kaadige, M.; Borazanci, E.; Gordon, M.; Moser, J.; Tsai, F.; Priceman, S. J.; Forman, S. J.; Xing, Y.; Altin, J.; Soldi, R.; Sharma, S.

10.1101/2024.12.12.628191 — immunology — Posted on 2025-04-25

495 An approach to produce thousands of single-chain antibody variants on a SPR biosensor chip for measuring target binding kinetics and for deep characterization of antibody paratopes

Cook, R. L.; Martelly, W.; Agu, C. V.; Gushgari, L. R.; Moreno, S.; Kesiraju, S.; Mohan, M.; Takulapalli, B.

10.1101/2025.01.11.632576 — immunology — Posted on 2025-04-25

496 Understanding the impact of blast-induced traumatic brain injury on brain cellular differentiation and mechanics at nanoscale

Masud, N.; Fonder, C.; McGovern, B.; Hasib, M. H. H.; Jackson, W. J.; Resendiz, D. C.; Rivers, C.; Bentil, S. A.; Sakaguchi, D. S.; Sarkar, A.

10.1101/2025.04.25.650643 — biophysics — Posted on 2025-04-28

497 De novo Design of a Peptide Modulator to Reverse Sodium Channel Dysfunction Linked to Cardiac Arrhythmias and Epilepsy

Mahling, R.; Hegyi, B.; Cullen, E. R.; Cho, T.; Rodriques, A. R.; Fossier, L.; Yehya, M.; Yang, L.; Chen, B.-X.; Katchman, A. N.; Chakouri, N.; Ji, R.; Wan, E. Y.; Kushner, J. S.; Marx, S. O.; Ovchinnikov, S.; Makinson, C. D.; Bers, D. M.; Ben-Johny, M.

10.1101/2025.04.25.649609 — biophysics — Posted on 2025-04-28

498 Mice Mucosal Leishmaniasis model shown high parasite load, increased cytotoxicity and impaired IL-10+ cells response

de-Matos-Guedes, H. L.; Da-Rocha, A. A.; Dos-Santos, J. S.; Bittencourt, I. S.; De-Almeida, D. B.; Manhaes, N. C. S.; Praxedes, H.; Romano, J. V. P.; Silva-Junior, E. B.; Silva-Goncalves, A. J.; Oliveira, M. P. L.; Covre, L. P.; Oliveira-Gomes, D. C.; Da-Cruz, A. M.; da Fonseca-Martins, A. M.

10.1101/2025.04.22.650112 — immunology — Posted on 2025-04-26

499 Acquired tick resistance in Peromyscus leucopus alters Ixodes scapularis infection

Fisk, E. A.; Leonard, C. J.; Rosche, K. L.; Ramirez-Zepp, E.; Abbott, J. R.; Owen, J. P.; Shaw, D. K.

10.1101/2025.04.22.650070 — immunology — Posted on 2025-04-26

500 Complex cooperativity in DNA origami revealed via design dependent defectivity

Majikes, J.; Hasni, A.; Haridas, S.; Robertson, J.; Pintar, A.; Zwolak, M.; Liddle, J. A.

10.1101/2025.04.23.650292 — biophysics — Posted on 2025-04-29

501 GM-CSF production by immune cells in steady state and autoimmune neuroinflammation mapped using fate reporting mice

Azizi, G.; Rasouli, J.; Naziri, H.; Gonzalez, M. V.; Garifallou, J.; Zhang, G.-X.; Ciric, B.; Rostami, A.

10.1101/2025.04.23.650273 — immunology — Posted on 2025-04-26

502 BIOPOINT: A particle-based model for probing nuclear mechanics and cell-ECM interactions via experimentally derived parameters

Chattaraj, S.; Zimmermann, J.; Pasqualini, F. S.

10.1101/2025.04.22.650069 — biophysics — Posted on 2025-04-29

503 IL-18 produced by pregnant uterus promotes essential inflammatory responses and fetoplacental growth

Ino, H.; Negishi, Y.; Horii, Y.; Koike, E.; Flavell, R. A.; Suzuki, S.; Morita, R.

10.1101/2025.04.23.649615 — immunology — Posted on 2025-04-26

504 Mapping the free energy landscape of K-Ras4B dimerization

Koukos, P. I.; Lesgidou, N.; Dehghani-Ghahnaviyeh, S.; Velez-Vega, C.; Duca, J. S.; Cournia, Z.

10.1101/2025.04.22.650040 — biophysics — Posted on 2025-04-29

505 Large-scale HLA immunopeptidome and interactome profiling in microglia

Klaisner, S.; Hao, Y.; Beilina, A.; Park, J.-H.; Li, Z.; Iba, M.; Tindall, C.; Jin, B.; Epstein, J.; Kowal, I.; Pantazis, C. B.; Carmiol, N.; Jarreau, P.; Washecka, N.; Weller, C.; Nalls, M. A.; Keuren-Jensen, K. V.; Singleton, A. B.; Cookson, M. R.; Qi, Y. A.

10.1101/2025.04.23.650327 — immunology — Posted on 2025-04-26

506 Observing Grazing Behavior Transitions in Cafeteria roenbergensis with Video-Rate Two-Photon Microscopy

Rahaman, A.; Chacon, M.; Xian, Y.; Xiao, C.; Li, C.

10.1101/2025.04.23.650267 — biophysics — Posted on 2025-04-29

507 ML-driven design of 3' UTRs for mRNA stability

Morrow, A. K.; Thornal, A.; Flynn, E. D.; Hoelzli, E.; Shan, M.; Garipler, G.; Kirchner, R.; Reddy, A. J.; Tabchouri, S.; Gupta, A.; Michel, J.-B.; Laserson, U.

10.1101/2024.10.07.616676 — synthetic biology — Posted on 2025-04-25

508 PTPN22 Regulates T Cell Synapse Formation through PSTPIP1-Dependent Actin Remodeling

Joseph, M. D.; Zaza, C.; Dalby, O.; Dustin, M.; Cope, A.; Simoncelli, S.

10.1101/2025.04.24.650379 — immunology — Posted on 2025-04-26

509 Membrane-enhanced repulsive interactions regulate protein diffusion in cell-size space

Sakuta, H.; Kanakubo, Y.; Takada, S.; Yanagisawa, N.; Oda, T.; Mayumi, K.; Sadakane, K.; Fujiwara, K.; Yanagisawa, M.

10.1101/2025.04.22.650139 — biophysics — Posted on 2025-04-29

510 Chronic Inflammation Induced Immature Neutrophils Drive Immunopathology During Subsequent Inflammatory Events

Alakesh, A.; Dorai, V. K.; Guttapadu, R.; Sagar, S. K.; Valakatte, M.; Vijaya Raghavan, J.; Mohandas, M.; S. R., K.; Chandra, N.; Jhunjhunwala, S.

10.1101/2025.04.24.650544 — immunology — Posted on 2025-04-26

511 Network-Based Kidney Allocation Simulation: Evaluating Organ Matching Strategies in Variable Hospital Networks

Ananthanarayanan, A.; Hu, B.; Sha, A.

10.1101/2025.04.22.650043 — synthetic biology — Posted on 2025-04-25

512 A toolkit to characterize protein polymerization from cryo-electron tomography data

Lee, F.; Aguilar, V. M. F.; Lawrence, T.; Mancino, P.; Lin, S.; Rochon, K.; Metskas, L. A.

10.1101/2025.04.22.650024 — biophysics — Posted on 2025-04-29

513 Generation of iPSC-derived CD4+ Th1 cells enhancing chimeric antigen receptor-T cell cytotoxicity

Furukawa, Y.; Ishii, M.; Kinoshita, S.; Goto, A.; Izumi, N.; Matsuzaki, K.; Yanashima, K.; Toyota, T.; Tachibana, K.; Ando, J.; Nakauchi, H.; Ando, M.

10.1101/2025.04.24.650471 — immunology — Posted on 2025-04-26

514 Lessons Learned from a Ligand-Unbinding Stress Test for Weighted Ensemble Simulations

Bogetti, A. T.; Yang, D. T.; Piston, H. E.; LeBard, D. N.; Chong, L. T.

10.1101/2025.04.23.650329 — biophysics — Posted on 2025-04-29

515 A Versatile Marker-Free Genome Engineering Platform to Overcome Homologous Recombination Bias in Microbes: A Case Study in Synechococcus elongatus UTEX 2973

Li, S.; Sun, T.; Liu, D.; Zhang, T.; Chen, L.; Zhang, W.

10.1101/2025.04.27.650839 — synthetic biology — Posted on 2025-04-27

516 Scalable TCR synthesis and screening enables antigen reactivity mapping in vitiligo

Gagliione, S. A.; Mukkamala, R. S.; Krishna, C.; Smith, B. E.; Wadsworth, M. H.; Jelinsky, S. A.; Perez, C. R.; Schmidt-Hong, L.; Katz, E. L.; Gellatly, K. J.; Ali, L. R.; Shen, J.; Holec, P. V.; Zhao, Q. H.; Chan, A. O.; Xu, E. J.; Kravarik, K. M.; Guzova, J. A.; Dobson, C. S.; Singh, H.; Garber, M.; Dougan, M.; Dougan, S. K.; Harris, J. E.; Winkler, A.; Birnbaum, M. E.

10.1101/2025.04.24.649726 — immunology — Posted on 2025-04-26

517 Quantifying the Cooperativity of Backbone Hydrogen Bonding

Xu, Y.; Huang, J.

10.1101/2025.03.29.646135 — biophysics — Posted on 2025-04-29

518 MARQO pipeline resolves multiparametric cellular and spatial organization in cancer tissue lesions

Buckup, M.; Figueiredo, I.; Ioannou, G.; Ozbey, S.; Cabal, R.; Tabachnikova, A.; Troncoso, L.; Le Berichel, J.; Zhao, Z.; Ward, S. C.; Hennequin, C.; Akturk, G.; Hamel, S.; Fiel, M. I.; Brody, R.; Schwartz, M.; Marron, T. U.; Kim-Schulze, S.; Gonzalez-Kozlova, E.; Roudko, V.; Hamon, P.; Merad, M.; Gnjatic, S.

10.1101/2025.04.24.650539 — immunology — Posted on 2025-04-26

519 Synthetic Cytosolic Splicing Enables Programmable mRNA-Encoded Receptors

Lampis, M.; Benenson, Y.

10.1101/2025.04.27.650769 — synthetic biology — Posted on 2025-04-27

520 Homeostatic neuroimmune rhythms are linked to priming of olfactory bulb responses to an intranasal inflammatory challenge

Pearson, G.; Baca, B.; Wang, J.; Gottwals, S.; Santos, N.; Burnside, A.; Denaroso, G.; Akli, S.; Karatsoreos, I.

10.1101/2025.04.24.647555 — immunology — Posted on 2025-04-26

521 Comparative analysis of convergent and divergent T7 RNA polymerase promoters for the synthesis of dsRNA in vivo and in vitro

Ross, S. J.; Ray, J.; Kilby, P. M.; Dickman, M. J.

10.1101/2025.04.28.650997 — synthetic biology — Posted on 2025-04-28

522 Mice Mucosal Leishmaniasis model shown high parasite load, increased cytotoxicity and impaired IL-10+ cells response

de Matos Guedes, H. L.; Da-Rocha, A. A.; Dos-Santos, J. S.; Bittencourt, I. S.; De-Almeida, D. B.; Manhaes, N. C. S.; Praxedes, H.; Romano, J. V. P.; Silva-Junior, E. B.; Silva-Goncalves, A. J.; Oliveira, M. P. L.; Covre, L. P.; Oliveira-Gomes, D. C.; Da-Cruz, A. M.; da Fonseca-Martins, A. M.

10.1101/2025.04.22.650112 — immunology — Posted on 2025-04-26

523 Immunometabolic Reprogramming of Monocytes in Tuberculosis Infection and Disease

Jameson, G.; Batten, I.; Dyer, A. H.; Geoghegan, C.; Murray, M.; McDonnell, N.; Murphy, D. M.; Connolly, S. A.; McLaughlin, A. M.; O Maoldomhnaigh, C.; Gleeson, L. E.; Keane, J.; Basdeo, S. A.

10.1101/2025.04.24.650431 — immunology — Posted on 2025-04-26

524 Predictive genome-wide CRISPR-mediated gene downregulation for enhanced bioproduction

Yunus, I. S.; Carruthers, D. N.; Chen, Y.; Gin, J. W.; Baidoo, E. E. K.; Petzold, C. J.; Garcia Martin, H.; Adams, P. D.; Mukhopadhyay, A.; Lee, T. S.

10.1101/2025.04.25.650723 — synthetic biology — Posted on 2025-04-29

525 Granuloma Dual RNA-Seq Reveals Composite Transcriptional Programs Driven by Neutrophils and Necrosis within Tuberculous Granulomas

Viswanathan, G.; Hughes, E. J.; Gan, M.; Xet-Mull, A. M.; Alexander, G.; Swain Lenz, D.; Liu, Q.; Tobin, D. M.

10.1101/2025.04.26.650783 — immunology — Posted on 2025-04-27

526 Resource competition shapes CRISPR-mediated gene activation

Manoj, K. A.; Del Vecchio, D.

10.1101/2024.07.03.601429 — synthetic biology — Posted on 2025-04-29

527 Antigen avidity drives the durability of the vaccine immune response.

Weidner, N. G.; Padilla, M. V.; Pruitt, L.; Cottrell, C. A.; Gonzales, K.; Kalyuzhniy, O.; Kubitz, M.; Alavi, N.; Phelps, N.; Weglarz, M.; Schief, W. R.; Abbott, R. K.

10.1101/2025.04.18.649567 — immunology — Posted on 2025-04-27

528 A Minimal Genetic Circuit for Cellular Anticipation

Pla-Mauri, J.; Sole, R.

10.1101/2025.04.22.649979 — synthetic biology — Posted on 2025-04-29

529 Inference and visualization of multi-scale cell tree for decoding functional diversity with scMustree

Xu, Y.; Wang, S.; Ding, L.; Li, H.-D.; Wang, J.

10.1101/2025.04.22.649953 — bioinformatics — Posted on 2025-04-26

530 Secondary lymphoid organ stroma activate and elaborate regulatory T cells to suppress autoantibody production in a novel model of systemic autoimmunity

Brodeur, T. Y.; Marshak-Rothstein, A.

10.1101/2025.04.21.649586 — immunology — Posted on 2025-04-28

531 Aurora kinase A promotes trained immunity via regulation of endogenous S-adenosylmethionine metabolism

Li, M.; Jin, H.; Liu, Y.; Wang, Z.; Li, L.; Wang, T.; Wang, X.; Zhang, H.; Huo, B.; Yu, T.; Wang, S.; Zhao, W.; Liu, J.; Huang, P.; Cui, J.; Xia, X.

10.1101/2024.11.11.622956 — immunology — Posted on 2025-04-28

532 scTransMIL Bridges Patient-Level Phenotypes and Single-Cell Transcriptomics for Cancer Screening and Heterogeneity Inference

Tang, Z.; Wang, F.; Yang, F.; Song, J.; Chen, C. Y.-C.; Yao, J.

10.1101/2025.04.22.649948 — bioinformatics — Posted on 2025-04-26

533 FlatProt: 2D visualization eases protein structure comparison

Olenyi, T.; Carl, C.; Senoner, T.; Koludarov, I.; Rost, B.

10.1101/2025.04.22.650077 — bioinformatics — Posted on 2025-04-26

534 A novel TIRAP-MyD88 inhibitor blocks TLR7- and TLR8-induced type I IFN responses

Nilsen, K. E.; Stenvik, J.; Skjesol, A.; Mestvedt, I. B.; Bakke, S. S.; Giambelluca, M. S.; Gravastrand, C. S.; Elamurugan, K.; Ryan, L.; Espevik, T.; Yurchenko, M.

10.1101/2025.04.25.650557 — immunology — Posted on 2025-04-28

535 A novel computational framework to identify translational potential of genetic mouse models in rare genetic obesity

Lefebvre, N.; Polosukhina, A.; Barata, A. C.; Leibovici, M.; Le Quere, P.; Paez-Pereda, M.; Saha, S.; Oury, F.

10.1101/2025.04.22.649931 — bioinformatics — Posted on 2025-04-26

536 Sialoglycans Modulate Siglec-5 - TLR4 Interactions in Osteoarthritis

Raberg, L.; Jia, F.; von Mentzer, U.; Venkatakrishnan, V.; Karlsson, N. G.; Stubelius, A.

10.1101/2025.03.18.643878 — immunology — Posted on 2025-04-28

537 Robust Bayesian Integrative Modeling of Single Cell and Spatially Resolved Transcriptomics Data

Li, H.; Zhu, B.; Jiang, X.; Ma, Y.; Xu, L.; Li, Q.

10.1101/2025.04.22.650087 — bioinformatics — Posted on 2025-04-26

538 makeTCR: a Flexible Platform for Rapid, Scalable, Single-Step T Cell Receptor Synthesis

Hamberger, M.; Neuhoff, M.-T.; Torres, C. M.; Tan, C. L.; Boschert, T.; Errerd, A.; Lindner, J. M.; Platten, M.; Green, E. W.

10.1101/2025.04.27.647198 — immunology — Posted on 2025-04-28

539 ReCellTy: Domain-specific knowledge graph retrieval-augmented LLMs workflow for single-cell annotation

Han, D.; Jia, Y.; Chen, R.; Han, W.; Guo, S.; Wang, J.

10.1101/2025.04.23.650201 — bioinformatics — Posted on 2025-04-26

540 Immunogenicity and Structural Features of a Stabilized Clade-C HIV-1 Env Derived from a Pediatric Elite-neutralizer

Singh, S.; Kumar, S.; Chatterjee, A.; Malhotra, L.; Rahman, A.; Andrabi, I.; Mondal, B.; Katpara, S.; Sharma, S.; Bhakri, H.; Gaur, A.; Bansal, T.; Pervez, M.; Iyer, V.; Hussain, A. W.; Ahmed, S.; Kumar, R.; Ethayathulla, A. S.; Lodha, R.; Dutta, S.; Luthra, K.

10.1101/2025.04.26.649701 — immunology — Posted on 2025-04-28

541 STING: A Graph Neural Network Approach for Computational Inference of Spatial Transcriptomic Profiles

Karambelkar, K. M.; Rao, A.; Baranwal, M.

10.1101/2025.04.23.650236 — bioinformatics — Posted on 2025-04-26

542 The ontogeny of immune tolerance: a model of early-life secretory IgA - gut microbiome interactions

Tepekule, B.; Lim, A. I.; Metcalf, C. J. E.

10.1101/2024.05.20.594845 — immunology — Posted on 2025-04-28

543 N-Orbit: towards a universal model and metric for comparing tissue microenvironments

Xiong, B.; Hu, Y.; Tan, K.

10.1101/2025.04.23.650192 — bioinformatics — Posted on 2025-04-26

544 Molecular Basis of Ionic Suppression of ZAP-70 Dependent T Cell Receptor Activation

Das, R.; Mallick, A. I.; Roy, S.; SenGupta, S.; Gangopadhyay, K.; Das, J.; Sinha, A.; Majumder, S.; Das, P. K.; Chakraborty, M. P.; Mondal, S.; Sinha, B.

10.1101/2025.04.25.650559 — immunology — Posted on 2025-04-28

545 A mechanistic model in sheep incorporating energy allocation trade-offs between the ewe and her lambs

Hiltpold, M.; Trepos, R.; Douhard, F.

10.1101/2025.04.23.650166 — bioinformatics — Posted on 2025-04-26

546 Stochastic LASSO for extremely high-dimensional genomic data

Baek, B.; Jo, J.; Kang, M.; Kim, Y.

10.1101/2025.04.22.650135 — bioinformatics — Posted on 2025-04-26

547 CryptoBank: A Resource for the Identification and Prediction of Cryptic Sites in Proteins

Febrer Martinez, P.; Borsatto, A.; Frohlking, T.; Gervasio, F. L.

10.1101/2025.04.23.650184 — bioinformatics — Posted on 2025-04-26

548 Breakthrough infection elicits synergistic broadly neutralizing antibodies targeting non-dominant epitopes on RBD and NTD in an individual of inactivated SARS-CoV-2 vaccine

Wang, Z.; Feng, H.; Ling, L.; Li, Y.; Lu, M.; Chen, X.; Hu, L.; Sun, Y.; Du, R.; Qin, R.; Chen, X.; Jiang, L.; Zuo, T.

10.1101/2025.04.27.650832 — immunology — Posted on 2025-04-28

549 IL4Pred2: Prediction of Interleukin-4 Inducing Peptides in Human and Mouse

Tomer, R.; Mehta, N. K.; Malik, S.; Jain, S.; Raghava, G. P. S.

10.1101/2025.04.23.650150 — bioinformatics — Posted on 2025-04-26

550 STCRpy: a software suite for T cell receptor structure parsing, interaction profiling and machine learning dataset preparation

Quast, N. P.; Deane, C. M.; Raybould, M. I. J.

10.1101/2025.04.25.650667 — immunology — Posted on 2025-04-28

551 Estimating the replicability of Brazilian biomedical science

Amaral, O. B.; Carneiro, C. F. D.; Neves, K.; Sampaio, A. P. W.; Gomes, B. V.; Abreu, M. B. d.; Tan, P. B.; Mota, G. P. S.; Goulart, R. N.; Fernandes, N. R. d. S.; Linhares, J. H.; Ibelli, A. M. G.; Sebollela, A.; Andricopulo, A. D.; Carvalho, A. A. V. d.; Silva, A. P. e.; Souza, A. S. O.; Lima, A. C. C. d.; Sousa, A. M. d.; Birbrair, A.; Borbely, A. U.; Machado, A. M.; Costa, A. d. C.; Vasconcelos, A. P. d.; Silva, A. H. B. d. L.; Souza, A. d.; Herrmann, A. P.; Bastos, A. P. A.; Nunes, A. C. C.; Castrucci, A. M. d. L.; Paula, A. B. R.; Waltrick, A. P. F.; Macedo, A. G. F. d.; Mecawi, A. S.; R

10.1101/2025.04.02.645026 — scientific communication and education — Posted on 2025-04-25

552 DeepSAP: Improved RNA-Seq Alignment by Integrating Transcriptome Guidance with Transformer-Based Splice Junction Scoring

Berakdar, F.; Wu, T. D.; Zhu, T.; Samadi, M.; Vats, P.

10.1101/2025.04.23.650072 — bioinformatics — Posted on 2025-04-26

553 DYNAMIC CHANGES TO THE INTESTINAL ENVIRONMENT OCCUR THROUGHOUT RECOVERY FROM EXPERIMENTAL ISCHAEMIC STROKE

Martin, R. M. L.; Mouat, I. C.; Whelan, R.; Hegarty, L. M.; Anderson, C. J.; Dockrell, D. H.; Bain, C. C.; Ho, G.-T.; McCulloch, L.

10.1101/2025.04.25.650631 — immunology — Posted on 2025-04-28

554 Giant endogenous viral elements in the genome of the model protist Euglena gracilis reveal past interactions with giant viruses

Jivaji, A. M.; Karki, S.; Franken, E.; Erazo-Garcia, M. P.; Barth, Z.; Aylward, F. O.

10.1101/2025.04.23.650285 — bioinformatics — Posted on 2025-04-26

555 Modeling human phenotypes in the nematode C. elegans during an undergraduate developmental biology course

The Augsburg BIO474 Consortium, ; Aburaide, S.; Ahmed, S.; Chamberlain, M.; Deleon, Y.; Elewa, A.; Hookom, A.; Juen, E.; Katasi, D.; Lee, B.; Meyer, S.; Millan, L.; Shaw, M.; Smith, D.; Vassallo, A.; Wangmo, T.; Wolfson, D.; Xiong, P.; Yaeger, L.

10.1101/2025.04.23.650323 — scientific communication and education — Posted on 2025-04-26

556 Interleukin-22 in enteroendocrine cells controls early-life gut motility through interactions with the microbiota

Rabahi, S.; Marachlian, E.; Guendel, F.; Mikdache, A.; Quintero-Castillo, K.; Maurin, L.; Di Donato, V.; Janardhana Kurup, A.; Salloum, Y.; Diabangouaya, P.; Gros, G.; Garcia Baudino, C.; Medina-Yanez, I.; Levraud, J.-P.; Lutfalla, G.; Del Bene, F.; Boekhorst, J.; Feijoo, C.; Eberl, G.; Brugman, S.; Sumbre, G.; Hernandez, P. P.

10.1101/2025.04.25.650580 — immunology — Posted on 2025-04-28

557 Enhancing Structure-aware Protein Language Models with Efficient Fine-tuning for Various Protein Prediction Tasks

Zhang, Y.; Qin, Y.; Pourmirzaei, M.; Shao, Q.; Wang, D.; Xu, D.

10.1101/2025.04.23.650337 — bioinformatics — Posted on 2025-04-26

558 T cell development from expanded hematopoietic progenitors reveals progression control by Lmo2, Erg, Spi1, Hoxa9, and Meis1

Shin, B.; Chang, S. J.; MacNabb, B. W.; Sidwell, T.; Williams, B. A.; Rothenberg, E. V.

10.1101/2025.04.22.649893 — immunology — Posted on 2025-04-28

559 Influenza virus infection in the lungs leads to pancytopenia and defective immune cell differentiation program in the thymus and bone marrow

Shinde, P.; Silvestri, G.; Kuppusamy, P.; Stamatos, N.; Rathinam, C. V.

10.1101/2025.04.22.650071 — immunology — Posted on 2025-04-28

560 Maximal Efficacy of Alternative Splicing is Ensured by Balanced Efficiency of U1 and U2AF

Hu, J.; Doueck, D. C.

10.1101/2025.04.24.650448 — bioinformatics — Posted on 2025-04-26

561 Microbiota Modulation Induces Elevated Duodenal Eosinophils Upon Gluten Exposure in Mice: Implications for Non-Coeliac Gluten Sensitivity

Pryor, J. C.; Hoedt, E. C.; Soh, W. S.; Fowler, S.; Caban, S.; Minahan, K.; Sherwin, S.; Nieva, C.; McCarthy, H.; Horvat, J.; Hedley, K. E.; Duncanson, K.; Talley, N. J.; Burns, G. L.; Keely, S.

10.1101/2025.04.22.649964 — immunology — Posted on 2025-04-29

562 Memorization Bias Impacts Modeling of Alternative Conformational States of Symmetric Solute Carrier Membrane Proteins with Methods from Deep Learning

Swapna, G. V. T.; Dube, N.; Roth, M. J.; Montelione, G. T.

10.1101/2024.07.15.603529 — bioinformatics — Posted on 2025-04-26

563 Heterologous immunization modulates B-cell epitope competition between helper peptides and the MPER segment in MPER/liposome vaccines

Khan, R. A.; Chen, J.; Donius, L.; Reinherz, E. L.; Kim, M.

10.1101/2025.04.23.650289 — immunology — Posted on 2025-04-29

564 Controlling False Discovery in CRISPR Screens

Dempster, J.; de Kegel, B.; Kalinka, A.; Vazquez, F.; Campbell, C. D.

10.1101/2025.04.24.650434 — bioinformatics — Posted on 2025-04-26

565 Structural insights into FOXP2 multimerization and interactions from AlphaFold3 modeling

Hassan, R. A.; Al-Fatlawi, A.

10.1101/2025.04.25.650520 — bioinformatics — Posted on 2025-04-27

566 Harnessing systemic glycolysis-TCA cycle axis to boost the host defense against newborn infection

Wu, Z.; Tien, N. T. N.; Klabunde, B.; Aasmul-Olsen, K.; Offersen, S. M.; Yen, N. T. H.; Muk, T.; Thysen, A. H.; Brix, S.; Brustad, N.; Wang, T.; Stokholm, J.; Bonnelykke, K.; Brunse, A.; Long, N. P.; Chawes, B.; Baek, O.; Nguyen, D. N.

10.1101/2025.04.23.650144 — immunology — Posted on 2025-04-29

567 Convergence and constraint in glucosinolate evolution across the Brassicaceae

Agosto Ramos, A.; Bird, K.; Jain, A.; Okegbe, O.; Holland, L.; Kliebenstein, D. J.

10.1101/2025.04.23.650103 — plant biology — Posted on 2025-04-25

568 Variational Autoencoders for Metabolomics: Data Imputation, Deconfounding, and Correlation Discovery

Lin, H.; Zhang, L.; Aksenov, A. A.; Jarmusch, A.; Lee, I.; Morton, J.

10.1101/2025.04.26.649581 — bioinformatics — Posted on 2025-04-27

569 GeomeTRe: accurate calculation of geometrical descriptors of tandem repeat proteins

Osmanli, Z.; Ferrero, E.; Monzon, A. M.; Tosatto, S. C. E.; Piovesan, D.

10.1101/2025.04.24.650440 — bioinformatics — Posted on 2025-04-27

570 DNA repair under heat: DNA Polymerase {lambda} modulates heat stress-induced mutagenesis in plants

Wootan, C. M.; Lutterman, J.; Springer, N. M.; Xu, X.; Zhang, F.

10.1101/2025.04.24.650460 — plant biology — Posted on 2025-04-26

571 Small-molecule perturbation profiling reveals a mechanistic link between STING signaling and lipid metabolism in macrophages and dendritic cells

Gmyrek, L.; Zhang, J.; Andrade, M.; Hillette, K. R.; Wu, X.; Park, J. M.

10.1101/2025.04.25.650730 — immunology — Posted on 2025-04-29

572 Enhanced semantic classification of microbiome sample origins using Large Language Models (LLMs)

Gaio, D.; Tackmann, J.; Perez-Molphe-Montoya, E.; Napflin, N.; Patsch, D.; Malfertheiner, L.; von Mering, C.

10.1101/2025.04.24.650461 — bioinformatics — Posted on 2025-04-27

573 Two genetically linked Arabidopsis TIR-type NLRs are required for immunity and interact with NLRs encoded in a segmentally duplicated genomic region

Luedke, D.; Yan, Q.; Zirngibl, M.-E.; Roth, C.; Klenke, M.; Gunkel, A.; Wiermer, M.

10.1101/2025.04.25.650432 — plant biology — Posted on 2025-04-26

574 Label-Free In-Line Characterization of Immune Cell Culture using Quantitative Phase Imaging

Serafini, C. E.; Gorti, V.; Casteleiro Costa, P.; Silva Trenkle, A. D.; Kanwar, B.; Wang, B.; Wicker, B.; Kippner, L. E.; LeCompte, I.; Chen, R. Q.; Joffe, B.; Li, Y.; Bowles-Welch, A. C.; Li, J.; Brown, C. E.; Kwong, G. A.; Balakirsky, S.; Roy, K.; Robles, F. E.

10.1101/2025.04.22.649403 — immunology — Posted on 2025-04-29

575 Understanding the selectivity of lysine negatively charged acyl modifications by OsCobB and its link with different plant stress condition

Roy, A. K.; Khan, S.; Dey, S.

10.1101/2025.04.25.649731 — plant biology — Posted on 2025-04-26

576 Parsing GTF and FASTA files using the eccLib Library

Chady, T.; Filutowska, Z. K.

10.1101/2025.04.24.650481 — bioinformatics — Posted on 2025-04-27

577 Herring roe oil exerts anti-psoriatic and immunomodulatory effects on the IL-17/23 signaling axis in macrophages, T-cells and a keratinocyte and fibroblast co-culture

Mildenberger, J.; Solberg, N. T.; Ostbye, T.-K. K.; Host, V.; Petrucelli, F.; Gammelsaeter, R.; Ronning, S. B.; Pedersen, M. E.

10.1101/2025.04.22.650092 — immunology — Posted on 2025-04-29

578 TOW links TIR1/AFB-mediated signalling with Receptor-Like Kinases in auxin canalization

Li, M.; Rydza, N.; Mazur, E.; Molnar, G.; Nodzynski, T.; Friml, J.

10.1101/2025.04.25.650570 — plant biology — Posted on 2025-04-28

579 High-throughput prediction of peptide structural conformations with AlphaFold2

Ille, A. M.; Markosian, C.; Burley, S. K.; Whitford, P. C.; Onuchic, J. N.; Pasqualini, R.; Arap, W.

10.1101/2024.12.03.626727 — bioinformatics — Posted on 2025-04-28

580 Memory T and B cells with recognition of avian influenza hemagglutinins are poorly responsive to existing seasonal influenza vaccines

Gonelli, C. A.; Koutsakos, M.; Esterbauer, R.; Zheng, M. Z. M.; Liu, Y.-C.; Zin, A.; Schwab, L. S. U.; Tilmanis, D.; Aban, M.; Hurt, A.; Kent, S. J.; Juno, J. A.; Wheatley, A. K.

10.1101/2025.04.28.651131 — immunology — Posted on 2025-04-29

581 Root exudation facilitate water infiltration and rewetting of dry soil

Gomez, E.; Mair, A.; Martin, I.; de las Heras Martinez, G.; Ptashnyk, M.; Dupuy, L. X.

10.1101/2025.03.26.645447 — plant biology — Posted on 2025-04-28

582 Learning copy number dependent variation in single tumour cell transcriptomes with deep generative models

Selega, A.; Maan, H.; Yu, C.; Tan, T. J.; Campbell, K. R.

10.1101/2025.04.21.649842 — bioinformatics — Posted on 2025-04-28

583 Comparison of CD4 T cell response in Plasmodium falciparum and vivax malaria

Nalubega, M.; Soon, M. S.; Andrew, D.; Dooley, N.; Loughland, J.; Engwerda, C.; Kenangalem, E.; Price, R. N.; Minigo, G.; Anstey, N. M.; Oyong, D.; Boyle, M. J.

10.1101/2025.04.28.651092 — immunology — Posted on 2025-04-29

584 Root exudation facilitates water infiltration and rewetting of dry soil

Gomez, E.; Mair, A.; Martin, I.; de las Heras Martinez, G.; Ptashnyk, M.; Dupuy, L. X.

10.1101/2025.03.26.645447 — plant biology — Posted on 2025-04-28

585 Optimal sequencing depth for measuring the concentrations of molecular barcodes

Ocari, T.; Zin, E. A.; Tekinsoy, M.; Van Meter, T.; Cammarota, C.; Dalkara, D.; Nemoto, T.; Ferrari, U.

10.1101/2024.06.02.596943 — bioinformatics — Posted on 2025-04-28

586 GPAT2 plays a role in the root cap cuticle formation of Arabidopsis that is not redundant to GPAT4 and GPAT8

Berhin, A.; Guerault, A.; De Bellis, D.; Nawrath, C.

10.1101/2025.04.25.650743 — plant biology — Posted on 2025-04-28

587 SPAED: Harnessing AlphaFold Output for Accurate Segmentation of Phage Endolysin Domains

Boulay, A.; Cremelie, E.; Galiez, C.; Briers, Y.; Rousseau, E.; Vazquez, R.

10.1101/2025.04.25.650745 — bioinformatics — Posted on 2025-04-28

588 Breeding for durable resistance in crops: defeated loci may act as Trojan horses compromising the effectiveness of major resistance genes.

Possamai, T.; Wiedemann-Merdinoglu, S.; Lacombe, M.-C.; Dorne, M.-A.; Griem, E.; Fuchs, R.; Bogs, J.; Baltenweck, R.; Avia, K.; Merdinoglu, D.; Hugueney, P.

10.1101/2025.04.25.650562 — plant biology — Posted on 2025-04-28

589 Reimagined Microphone-Free Acoustic Volumetry: An Open, DIY Platform for Global Phenotyping

Haghshenas, A.; Emam, Y.

10.1101/2025.04.25.650573 — plant biology — Posted on 2025-04-28

590 OrfViralScan 3.0: An intuitive tool for the identification and tracking of open reading frames in viral genomes

Reinosa, R.

10.1101/2025.04.26.650794 — bioinformatics — Posted on 2025-04-28

591 Defender or accomplice? Dual roles of plant vesicle trafficking in restricting and enabling geminiviral systemic infection.

Cana-Quijada, P.; Morales-Martinez, P.; Rosas-Diaz, T.; Jimenez-Gongora, T.; Navarro, J. A.; Lozano-Duran, R.; Castillo, A. G.; Pallas, V.; Bejarano, E.

10.1101/2025.04.25.650579 — plant biology — Posted on 2025-04-28

592 Assessment of Reported Error Rates in Crosslinking Mass Spectrometry

Rappsilber, J.; Fischer, L.; Lenz, S.; Kolbowski, L.; bruce, j. e.; Chalkley, R. J.; Hoopmann, M. R.; Keller, A.; Moritz, R. L.; Shteynberg, D.; Trnka, M.; Viner, R.

10.1101/2025.04.27.649519 — bioinformatics — Posted on 2025-04-28

593 A global survey of intramolecular isopeptide bonds

Costa, F.; Riziotis, I.; Andreeva, A.; Kalwan, D.; de Jong, J.; Hinchliffe, P.; Parmeggiani, F.; Race, P. R.; Burston, S. G.; Bateman, A.; Barringer, R.

10.1101/2025.04.25.650565 — bioinformatics — Posted on 2025-04-28

594 Replicated repurposing of an ancestral transcriptional complex in land plants

Kongsted, T. E.; Romani, F.; Airoldi, C. A.; Haseloff, J.; Glover, B. J.

10.1101/2025.04.25.650595 — plant biology — Posted on 2025-04-28

595 A real-time detection and non-destructive warning method for zebrafish body surface anomalies based on improved YOLOv8 framework

Cao, D.; Yang, H.; Guo, C.; Cheng, Y.; Zhang, W.; Shi, M.; Xia, X.-Q.

10.1101/2025.04.28.649888 — bioinformatics — Posted on 2025-04-28

596 Insight into the genetic network governing long-stalked glandular trichome development in Nicotiana tabacum

Berhin, A.; Ramirez, A.; Peeters, M.; Vannieuwenhuyze, M.; Legay, S.; El Amraoui, B.; Hachez, C.

10.1101/2025.04.25.650498 — plant biology — Posted on 2025-04-28

597 Systematic discovery of single-cell protein networks in cancer with Shusi

Zhang, T.; Yu, J.; Lou, S.; Liang, Z.; Liang, Y.; Li, Z.; Wang, H.; Pei, S.; Shen, N.

10.1101/2025.04.27.649905 — bioinformatics — Posted on 2025-04-28

598 Bayesian phylodynamic inference of multi-type population trajectories using genomic data

Vaughan, T. G.; Stadler, T.

10.1101/2024.11.26.625381 — bioinformatics — Posted on 2025-04-28

599 Breaking the Phalanx: Overcoming Bacterial Drug Resistance with Quorum Sensing Inhibitors that Enhance Therapeutic Activity of Antibiotics

Beasley, J.-M.; Dorjsuren, D.; Jain, S.; Rath, M.; Scheufen Tieghi, R.; Tropsha, A.; Simeonov, A.; Zakharov, A. V.; Muratov, E.

10.1101/2025.01.17.633658 — bioinformatics — Posted on 2025-04-28

600 SCassist: An AI Based Workflow Assistant for Single-Cell Analysis

Nagarajan, V.; Shi, G.; Arunkumar, S.; Liu, C.; Gopalakrishnan, J.; Nath, P. R.; Jang, J.; Caspi, R.

10.1101/2025.04.22.650107 — bioinformatics — Posted on 2025-04-28

601 Learning to Estimate Sample-specific Transcriptional Networks for 7000 Tumors

Ellington, C. N.; Lengerich, B. J.; Watkins, T. B.; Yang, J.; Adduri, A.; Mahbub, S.; Xiao, H.; Kellis, M.; Xing, E. P.

10.1101/2023.12.01.569658 — bioinformatics — Posted on 2025-04-28

602 SIMIT-seq: a bead-free, scalable microfluidic platform for single cell mRNA sequencing with ultrahigh cell-indexing rate

Duan, M.; Gao, W.; Li, G.; Cai, Y.; Zhao, Z.; Lan, X.; Wang, D.; Xing, X.; Luo, Y.

10.1101/2025.04.23.650129 — bioinformatics — Posted on 2025-04-28

603 Impact of Population Pressure on Forest Resources Depletion in Yayo coffee forest Biosphere Reserve, Ilubabor Zone, Oromia Regional State, Southwest Ethiopia

Hunde, F. M.; Benti, A. A.; Kepula, T. J.

10.1101/2025.04.26.650807 — plant biology — Posted on 2025-04-29

604 Facilitating User Interaction with the Tuberculosis Mutation Catalogue using AI Tools

Moreno-Molina, M.; Suresh, A.; Colman, R. E.; Rodwell, T. C.

10.1101/2025.04.25.650567 — bioinformatics — Posted on 2025-04-28

605 Nitrogen nutrition impacts grapevine esca leaf symptom incidence, physiology and metabolism

DellAcqua, N.; Gambetta, G. A.; Comont, G.; Ferrer, N.; Rochepeau, A.; Petriacq, P.; Delmas, C. E. L.

10.1101/2024.08.31.610625 — plant biology — Posted on 2025-04-29

606 CS-Fold: Advancing RNA Structure Predictions through Phylogenetic Modelling of Compensatory Mutations in Deep Neural Networks

Zhou, J.; Xu, J.; Wen, J.; Parker, B. J.

10.1101/2025.04.27.650904 — bioinformatics — Posted on 2025-04-28

607 A citrullination-ubiquitination pathway controls pre-meiotic H1 eviction and is essential for gametogenesis in Arabidopsis

Li, Y.; Fei, D.; Schubert, J.; Rutowicz, K.; Kaczmarska, Z.; Linares, A.; Giraldo-Fonseca, A.; Bischof, S.; Grossniklaus, U.; Baroux, C.

10.1101/2025.04.18.649492 — plant biology — Posted on 2025-04-29

608 WITHDRAWN: A gall-forming insect manipulates hostplant phytohormone synthesis, concentrations, and signaling

Body, M. J.; Appel, H. M.; Edger, P. P.; Schultz, J. C.

10.1101/658823 — plant biology — Posted on 2025-04-29

609 Quantum algorithm for identifying RNA 3D motifs by processing RNA secondary structure graphs

Fang, J.-K.; Guo, F.; Ma, T.; Zhang, Y.; Wang, O.; Huang, J.-H.; Li, Y.

10.1101/2025.04.25.650554 — bioinformatics — Posted on 2025-04-28

610 Tumor Microenvironment in Ovarian Cancer through Spatial Transcriptomics and Identification of Key Gene Expression Profiles

Kırboga, K. K.; Kücüksille, E. U.; Rudrapal, M.; Aktas, E.; Achar, R. R.; Deshpande, G.; Stupin, V.; Silina, E.

10.1101/2025.04.25.650590 — bioinformatics — Posted on 2025-04-28

611 Gut microbial ecosystems differ across metabolic and obesity phenotypes

Lacruz-Pleguezuelos, B.; Bazan, G. X.; Romero-Tapiador, S.; Freixer, G.; Fernandez-Cabezas, J.; Aguilar-Aguilar, E.; Martin-Segura, A.; Fernandez, L. P.; Espinosa-Salinas, I.; Ramirez de Molina, A.; Morales, A.; Tolosana, R.; Ortega-Garcia, J.; Pancaldi, V.; Marcos-Zambrano, L. J.; Carrillo de Santa Pau, E.

10.1101/2025.04.25.650405 — bioinformatics — Posted on 2025-04-28

612 Machine Learning Prediction of HIV1 Drug Resistance against Integrase Strand Transfer Inhibitors

Chui, C. Y.; Chan, A. W. E.

10.1101/2025.04.25.650610 — bioinformatics — Posted on 2025-04-28

613 Software and pipelines for registration and analyses of rodent brain image data in reference atlas space

Puchades, M. A.; Yates, S. C.; Csucs, G.; Carey, H.; Balkir, A.; Leergaard, T. B.; Bjaalie, J. G.

10.1101/2025.04.25.650563 — bioinformatics — Posted on 2025-04-28

614 TARPON - a Telomere Analysis and Research Pipeline Optimized for Nanopore

Deimler, N.; Ho, D.; Baumann, P.

10.1101/2025.04.22.649940 — bioinformatics — Posted on 2025-04-29

615 Assemblies of long-read metagenomes suffer from diverse errors

Trigodet, F.; Sachdeva, R.; Banfield, J. F.; Eren, A. M.

10.1101/2025.04.22.649783 — bioinformatics — Posted on 2025-04-29

616 Integrating population-level and cell-based signatures for drug repositioning

He, C.; Xu, Y.; Zhou, Y.; Fan, J.; Cheng, C.; Meng, R.; Wu, L.; Pan, R.; Shah, R. V.; Gamazon, E. R.; Zhou, D.

10.1101/2023.10.25.564079 — bioinformatics — Posted on 2025-04-29

617 Plasticity and genetics shape thermal tolerance in non-native populations of the European green crab (Carcinus maenas)

Venkataraman, Y. R.; Kelso, J. C.; Payne, C.; Freitas, H. L.; Kohler, J.; Tepolt, C. K.

10.1101/2025.04.22.650023 — physiology — Posted on 2025-04-26

618 A low protein diet drives short- and long-term improvements in metabolic health in a mouse model of sleeve gastrectomy

Illiano, J.; Green, C. L.; Chao, A.; Lopez, L.; Schaepkens, O.; Jang, C.; Lamming, D.; Harris, D. A.

10.1101/2025.04.23.650310 — physiology — Posted on 2025-04-26

619 UniScore, a unified and universal measure for peptide identification by multiple search engines

Tabata, T.; Yoshizawa, A. C.; Ogata, K.; Chang, C.-H.; Araki, N.; Sugiyama, N.; Ishihama, Y.

10.1101/2024.10.09.617445 — bioinformatics — Posted on 2025-04-29

620 Metapipeline-DNA: A Comprehensive Germline & Somatic Genomics Nextflow Pipeline

Patel, Y.; Zhu, C.; Yamaguchi, T. N.; Wang, N. K.; Wiltsie, N.; Zeltser, N.; Gonzalez, A. E.; Winata, H. K.; Pan, Y.; Mootor, M. F. E.; Sanders, T.; Fitz-Gibbon, S. T.; Kandoth, C.; Livingstone, J.; Liu, L. Y.; Carlin, B.; Holmes, A.; Oh, J.; Sahrmann, J.; Tao, S.; Eng, S.; Hugh-White, R.; Pashminehazar, K.; Park, A.; Beshlikyan, A.; Jordan, M.; Wu, S.; Tian, M.; Arbet, J.; Neilsen, B.; Haas, R.; Bugh, Y. Z.; Kim, G.; Salmingo, J.; Zhang, W.; Anand, A.; Hwang, E.; Neiman-Golden, A.; Steinberg, P.; Zhao, W.; Anand, P.; Agrawal, R.; Tsai, B. L.; Boutros, P. C.

10.1101/2024.09.04.611267 — bioinformatics — Posted on 2025-04-29

621 Decoupling of plastid and endomembrane homeoviscous response to low temperature and darkness in Phaeodactylum tricornutum

Sérès, Y.; Serbutoviez-Verville, C.; Bonnarde, R.; Schilling, M.; Simon, M.; Salvaing, J.; Jouhet, J.; Marechal, E.; Amato, A.

10.1101/2025.04.24.650388 — physiology — Posted on 2025-04-26

622 PPI-ID: Streamlining Protein-Protein Interaction Prediction through Domain and SLiM Mapping

Goodwin, H. V.; Atkinson, N. S.

10.1101/2025.04.22.649917 — bioinformatics — Posted on 2025-04-29

623 Red Blood Cells Serve as a Primary Glucose Sink to Improve Glucose Tolerance at Altitude

Marti-Mateos, Y.; Midha, A. D.; Huynh, H.; Flanigan, W. R.; Blume, S. Y.; Jain, I. H.

10.1101/2025.04.24.650365 — physiology — Posted on 2025-04-26

624 PNPLA3 I148M Reduces Hepatic Triacylglycerol Secretion and Mitigates Left Ventricular Diastolic Dysfunction in MASH Diet Mice

Butcko, A. J.; Kamali, P.; Tiwari, N.; Rahman, A. A.; Teskey, G.; Adeshina, K. A.; Singh, N. K.; Granneman, J. G.; Mottillo, E. P.

10.1101/2025.04.24.650494 — physiology — Posted on 2025-04-27

625 Automating the Curation of DNA Barcode Databases for Vascular Plants

Kolter, A.; Hebert, P.

10.1101/2025.04.22.650100 — bioinformatics — Posted on 2025-04-29

626 Understanding Protein Language Model Scaling on Mutation Effect Prediction

Hou, C.; Liu, D.; Zafar, A.; Shen, Y.

10.1101/2025.04.25.650688 — bioinformatics — Posted on 2025-04-29

627 Accumulation of Dietary and Non-Enzymatic Oxysterols in Preeclamptic Placentas: Insights into Cholesterol Dynamics in Pregnancy Complications

Zou, L.; Maldonado-Pereira, L.; Ticiani, E.; Sethuraman, V.; Olomu, N.; Long, R.; Veiga-Lopez, A.; Medina-Meza, I. G.

10.1101/2024.11.13.623499 — physiology — Posted on 2025-04-28

628 Metagenomic-scale analysis of the predicted protein structure universe

Yeo, J.; Han, Y.; Bordin, N.; Lau, A. M.; Kandathil, S. M.; Kim, H.; Karin, E. L.; Mirdita, M.; Jones, D. T.; Orengo, C.; Steinegger, M.

10.1101/2025.04.23.650224 — bioinformatics — Posted on 2025-04-29

629 Shear Stress Regulates ABCA1-dependent Membrane Cholesterol Content in Endothelial Cells Facilitating H2S-dependent Vasodilation

Anderson, J. R.; Kanagy, N. L.; Gonzalez Bosc, L. V.; Naik, J. S.

10.1101/2025.04.21.649801 — physiology — Posted on 2025-04-28

630 Association of ulcerative colitis with atopic dermatitis: identification of shared and unique mechanisms by construction and computational analysis of disease maps

Lopata, O.; Acencio, M. L.; Wang, X.; Hemedan, A. A.; Chao, M. J.; Jelinsky, S. A.; Tran, F.; Rosenstiel, P.; Li Yim, A. Y. F.; Schneider, R.; Satagopam, V.; Ostaszewski, M.

10.1101/2025.04.23.650149 — bioinformatics — Posted on 2025-04-29

631 Humidity as a zeitgeber for circadian entrainment of insect systems

Chen, S.-C.; Goodhart, G.; Eaton, D.; Catlett, N.; Cady, T.; Tran, H.; Lutz, L. E.; Wang, L.; Girard, E.; Savino, J.; Perry, J.; Hall, L.; Bidiwala, A.; Tarter, E.; Tompkin, J.; Greene, N.; Benoit, J.

10.1101/2024.09.04.611265 — physiology — Posted on 2025-04-28

632 Particular sequence characteristics induce bias in the detection of polymorphic transposable element insertions

Verneret, M.; Le, V. A.; Faraut, T.; Turpin, J.; Lerat, E.

10.1101/2024.09.25.614865 — bioinformatics — Posted on 2025-04-29

633 Mechanical unloading coupled with coronary reperfusion reduces fibrosis and stimulates cardiomyocyte proliferation after myocardial infarction

Bello, S. O.; Singh, C.; Perbellini, F.; Punjabi, P. P.; Terracciano, C. M.

10.1101/2025.04.25.650549 — physiology — Posted on 2025-04-28

634 HGTs are not SPRs: In the presence of ghost lineages, series of Horizontal Gene Transfers do not result in series of Subtree Pruning and Regrafting

Tannier, E.; Tricou, T.; Benali, S.; de Vienne, D. M.

10.1101/2024.11.22.624805 — bioinformatics — Posted on 2025-04-29

635 The response of the skeletal muscle transcriptome to exercise in chronic kidney disease

Baker, L.; Graham-Brown, M.; Wilkinson, T.; Smith, A.; Watson, E.

10.1101/2025.04.25.650585 — physiology — Posted on 2025-04-28

636 Post activation potentiation is greater in human triceps brachii versus triceps surae muscles

Zoughaib, W. S.; Fry, M. J.; Singhal, A.; Hoffman, R. L.; Coggan, A. R.

10.1101/2025.04.23.650262 — physiology — Posted on 2025-04-29

637 MBD2/3 lost its methyl-CpG binding ability in multiple families of Holometabola

Israel, E.; Länger, Z. M.; Heckenhauer, J.; Kurtz, J.; Prohaska, S.

10.1101/2025.04.22.650097 — bioinformatics — Posted on 2025-04-29

638 EGFR activation in cholangiocytes promotes extrahepatic bile duct regeneration after injury

Calder, A. N.; Sakaguchi, T.; Peter, M.; Tobias, J.; Frankel, T.; Razumilava, N.

10.1101/2025.04.22.649788 — physiology — Posted on 2025-04-29

639 Tile-X: A vertex reordering approach for scalable long read assembly

Bhowmik, O.; Kalyanaraman, A.

10.1101/2025.04.21.649853 — bioinformatics — Posted on 2025-04-29

640 General Theory of Metabolism related to Animal's Taxonomy and Size

Pelz, P. F.

10.1101/2025.04.08.647784 — physiology — Posted on 2025-04-29

641 Quantification and differential analysis of mass spectrometry proteomics data with probabilistic recovery of information from missing values

Li, M.; Cobbold, S. A.; Smyth, G. K.

10.1101/2025.04.28.651125 — bioinformatics — Posted on 2025-04-29

642 Modulation of neurofluid fluctuation frequency by baseline carbon dioxide in awake humans: the role of the autonomic nervous system

Zhong, X. Z.; Chang, C.; Jean Chen, J.

10.1101/2024.06.05.597472 — physiology — Posted on 2025-04-29

643 Zero-shot design of drug-binding proteins via neural selection-expansion

Fry, B. P.; Slaw, K.; Polizzi, N. F.

10.1101/2025.04.22.649862 — bioengineering — Posted on 2025-04-25

644 Cerebral Organoids with Integrated Endothelial Networks Emulate the Neurovascular Unit and Mitigate Core Necrosis

Fumado Navarro, J.; Crilly, S.; Chan, W. K.; Browne, S.; Mason, J.; Giraldo, C. V.; Pandit, A.; Lomora, M.

10.1101/2025.04.23.650161 — bioengineering — Posted on 2025-04-26

645 Effects of Electrocardiograms QRS Detection Algorithms in Heart Rate Variability Metrics

Weinstein, A.; Otero, M.; Rodino, J.

10.1101/2025.04.23.650299 — bioengineering — Posted on 2025-04-26

646 An Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity

Ramalingam, M. B.; Oh, H. J.; Sears, J. D.; Chen, C.-H.; Vala, A.; Liu, S.; Talbot, K. M.; Hossain, M. A.; Brown, P. J.; Houliston, S.; Garcia Perez, J.; Li, F.; Amare, M. G.; Halfmann, P.; Smith, J.; Hirsch, A.; Arrowsmith, C. H.; Halabelian, L.; Vargason, A. M.; Counago, R. M.; Arnold, J. J.; Cameron, C. E.; Moorman, N. J.; Heise, M. T.; Willson, T. M.

10.1101/2025.04.24.650479 — pharmacology and toxicology — Posted on 2025-04-28

647 Collagen Nanofiber Reinforced Alginate Hydrogel Tube Microbioreactors for Cell Culture

Wu, X.; Yang, Y.; Pan, Y.; Wang, Y.; Lian, X.; Dong, C.; Wang, S.; Wang, A.; Lei, Y.

10.1101/2025.04.23.650245 — bioengineering — Posted on 2025-04-26

648 Nanotechnology-Driven Synergy: Research Effects of Curcumin Nanosuspension and Fluconazole Combination in Overcoming Azole Resistance in Candida Albicans

Zhang, C.; Liu, J.; Sun, S.

10.1101/2025.04.25.650561 — pharmacology and toxicology — Posted on 2025-04-28

649 Closed-loop sonothermogenetic control of CAR T cells for metronomic brain cancer therapy

Zamat, A.; Kim, C.; Sridhar, S.; Fabrega, S.; Sen, R.; Campbell, N.; Oliver, S. A.; Zha, Z.; Thiveaud, C.; Kulaksizoglu, E.; Brienen, M.; Woodworth, G.; Arvanitis, C.; Kwong, G. A.

10.1101/2025.04.23.650339 — bioengineering — Posted on 2025-04-26

650 Engineering nanoparticles that target fibroblast activation protein in cardiac fibrosis

Maduka, C. V.; Rodriguez-Rivera, G. J.; Garay-Sarmiento, M.; Perry, A. R.; Boyd, S.; Worthington, K.; Obenreder, M.; Rydahl-Kim, S.; Spinale, F. G.; Burdick, J. A.

10.1101/2025.04.23.650330 — bioengineering — Posted on 2025-04-26

651 Exploring Phage-Staphylococcus aureus Host Dynamics Through Innovative In Vitro Experiment and Pharmacokinetic/pharmacodynamic Modeling

Royet, K.; Blazere, L.; Helluin, E.; Coignet, L.; Plumet, L.; Bonhomme, M.; Kolenda, C.; Garreau, R.; Valour, F.; Medina, M.; Laurent, F.; Goutelle, S.

10.1101/2025.04.25.650594 — pharmacology and toxicology — Posted on 2025-04-29

652 RSPO2-based peptibodies conjugated with pyrrolobenzodiazepine dimer or camptothecin analogs demonstrate potent anti-tumor activity by targeting the three receptors LGR4/5/6

Toh, Y.; Tu, J.; Wu, L.; Aldana, A.; Wen, J. J.; Li, L.; Pan, S.; Liu, Q. J.

10.1101/2025.04.25.650662 — pharmacology and toxicology — Posted on 2025-04-29

653 Precision Breathing: Asthma Phenotyping via Machine Learning

Churcher, N. K. M.; Ganguly, A.; Ayisi-Boateng, N. K.; Adankwah, E. K.; Ansah, M. K.; Phillips, R. O.; Prasad, S.

10.1101/2025.04.24.650383 — bioengineering — Posted on 2025-04-26

654 Site-Specific Noninvasive Delivery of Retrograde Viral Vectors to the Brain

Harb, M.; Nouraein, S.; Szablowski, J. O.

10.1101/2025.04.24.650522 — bioengineering — Posted on 2025-04-26

655 Homology-Based Enzymatic Assembly of Modular T7 Phage Genome

Vu, J.; Chan, Z.; Murphy, N.; Shirali, A.; Han, K.; Averesch, N. J.; Kyriakakis, P.

10.1101/2025.04.24.650493 — bioengineering — Posted on 2025-04-26

656 Human Plasma-Like Medium Promotes Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes

Zhange, X.; Simmons, A. D.; Huggler, K. S.; Feeney, A. K.; Cantor, J. R.; Skala, M. C.; Palecek, S. P.

10.1101/2025.04.24.650456 — bioengineering — Posted on 2025-04-26

657 Role of GLP1-receptor-mediated α-β-cell communication in functional β-cell heterogeneity.

Balasenthilkumaran, N. V.; Bombek, L. K.; Ramirez, D.; Klemen, M. S.; Leitgeb, E. P.; Kercmar, J.; Kopecky, J.; Zhang, Y.; Sethiya, A.; Takaoglu, A.; Prabhu, D.; Fan, A.; Vitalapuram, S.; Dolensek, J.; Gosak, M.; Benninger, R. K.; Stozer, A.; Kravets, V.

10.1101/2025.04.25.650736 — bioengineering — Posted on 2025-04-27

658 Personalized CRISPR Knock-In Cytokine Gene Therapy to Remodel the Tumor Microenvironment and Enhance CAR T Cell Therapy in Solid Tumors

Launspach, M.; Macos, J.; Afzal, S.; Hohmann, J.; Beez, S.; Pilgram, M.; van der Ven, C.; Lachiheb, C.; Andersch, L.; Jens, M.; Appis, M. L.; Zirngibl, F.; Kath, J.; Stecklum, M.; Anders, K.; Wagner, D. L.; Kuehn, R.; Eggert, A.; Kuenkele, A.

10.1101/2025.04.25.650703 — bioengineering — Posted on 2025-04-27

659 3D Chemotaxis Chip for Investigating Natural Killer Cell Migration Mechanisms

Temples, M. N.; Lightsey, S.; Conklin, T.; Phelps, E. A.; Sharma, B.

10.1101/2025.04.21.649825 — bioengineering — Posted on 2025-04-28

660 CRISPR-Edited DPSCs, Constitutively Expressing BDNF Enhance Dentin Regeneration in Injured Teeth

Kim, J. H.; Irfan, M.; Sreekumar, S.; Phimon, A.; Chung, S.

10.1101/2024.12.11.627879 — bioengineering — Posted on 2025-04-28

661 Barley disease screening: a multiplex digital droplet PCR approach for the detection of Ramularia collo-cygni, Rhynchosporium graminicola and Pyrenophora teres

Zia, R.; Popper, Z. A.; Kildea, S.

10.1101/2024.12.18.629171 — pathology — Posted on 2025-04-28

662 Predicting Savings in the Metabolic Cost of Running With an Exotendon

Stingel, J.; Bianco, N. A.; Ong, C.; Hicks, J. L.; Delp, S.

10.1101/2025.04.15.648814 — bioengineering — Posted on 2025-04-28

663 spRefine Denoises and Imputes Spatial Transcriptomics with a Reference-Free Framework Powered by Genomic Language Model

Liu, T.; Huang, T.; Jin, W.; Chu, T.; Ying, R.; Zhao, H.

10.1101/2025.04.22.649977 — genomics — Posted on 2025-04-25

664 Topology Determines DNA Origami Diffusion in Intestinal Mucus

Tollemeto, M.; Paffen, L. J. M. M.; Thamdrup, L. H. E.; Boisen, A.; Van Hest, J.; Patino Padial, T.

10.1101/2025.04.25.650571 — bioengineering — Posted on 2025-04-28

665 AI-driven computational pathology for recurrence risk assessment in early-stage breast cancer

Yan, C.; Li, L.; Qian, X.; Ou, Y.; Huang, Z.; Ruan, Z.; Xiang, W.; Liu, H.; Liu, J.

10.1101/2025.04.26.648504 — pathology — Posted on 2025-04-29

666 Resolving the molecular niche of pulmonary fibrosis using cryopreserved human precision cut lung slices

Sivankutty, I.; Arava, M.; Kim, J. H.; An, Z.; Matsui, E.; Sahu, D.; Cai, C.; Behrsing, H.; Gerlovin, K.; Paul, L. M.; Suki, B.; Krishnan, R.; Choudhury, S.

10.1101/2025.04.22.649643 — genomics — Posted on 2025-04-26

667 Hydrophobic Ion Pairing for Simple, Non-Toxic Transfection

Gray, M. A.; Seeler, M.; Montoya, C.; Park, J.; Mai, L. D.; Whitehead, K. A.; Champion, J. A.

10.1101/2025.04.25.650611 — bioengineering — Posted on 2025-04-28

668 Genome-wide association mapping and predictive modeling of wet bean mass in a diverse cacao collection

Bhatt, J.; Baek, I.; Lim, S.; Lee, D.; Jang, J. H.; Cohen, S. P.; Lovelace, A. H.; Kim, M. S.; Meinhardt, L. W.; Park, S.; Ahn, E.

10.1101/2025.04.23.650203 — genomics — Posted on 2025-04-26

669 Mesoscopic SCAPE Microscope with a Rescanned, Super-oblique Illumination Plane

Cao, Z.; Jiapeng, Z.; Zhang, C.; Wang, Q.; Huang, Y.; Liu, W.; Shen, B.; Chai, Y.; Zhong, Z.; Li, H.; Wen, Q.; Wang, H.; Liang, W.

10.1101/2025.04.25.650616 — bioengineering — Posted on 2025-04-28

670 Extensive modulation of a conserved cis-regulatory code across 589 grass species

Hale, C. O.; Hsu, S.-K. O.; Zhai, J.; Schulz, A. J.; AuBuchon-Elder, T.; Costa-Neto, G. M. F.; Gelfond, A.; El-Walid, M. Z.; Hufford, M.; Kellogg, E. A.; La, T.; Marand, A. P.; Seetharam, A. S.; Stitzer, M. C.; Scheben, A.; Wrightsman, T.; Romay, C.; Buckler, E. S.

10.1101/2025.04.23.650228 — genomics — Posted on 2025-04-26

671 Bioassembly of region-specific fibrocartilage microtissues to engineer zonally defined meniscal grafts

Kronemberger, G. S.; Chattahy, K.; Spagnuolo, F. D.; Karam, A. S.; Kelly, D. J.

10.1101/2025.04.25.650568 — bioengineering — Posted on 2025-04-28

672 Large-scale skin metagenomics reveals extensive prevalence, coordination, and functional adaptation of skin microbiome dermotypes across body sites

Li, C.; Ravikrishnan, A.; Wijaya, I.; Naim, A. N. M.; Gounot, J.-S.; Wearne, S.; On, Y. Y.; Ho, E. X. P.; Ang, Q. Y.; Chia, M.; Amanda, N. H. Q.; Ramaswami, S.; Yew, Y. W.; Loh, M.; Ong, R. Y.; Ng, F.; Lee, S. H.; Chan, J.; The HELIOS Study team, ; Regina, V. R.; Dawson, T.; Chambers, J.; Common, J.; Nagarajan, N.

10.1101/2025.04.24.650393 — genomics — Posted on 2025-04-26

673 Nuclear Mitochondrial Sequences in Great Ape Telomere-to-Telomere Genomes

Torres-Gonzalez, E.; Cremona, M. A.; Storer, J. M.; Ventura, M.; O'Neill, R. J.; Makova, K. D.

10.1101/2025.04.24.650511 — genomics — Posted on 2025-04-26

674 Optogenetic translocation to subcellular compartments through regulation of protein avidity

Huang, Z.; Gu, Y.; Gao, Y.; Byrd, A.; Bader, H.; Bugaj, L. J.

10.1101/2025.04.23.650348 — bioengineering — Posted on 2025-04-28

675 From Fragmentation to Resolution: High-Fidelity Genome Assembly of Zancudomyces culisetae through Comparative Insights from PacBio, Nanopore, and Illumina Sequencing

Yang, H.; Wang, Y.

10.1101/2025.04.24.650499 — genomics — Posted on 2025-04-26

676 Improving Targeting Specificity of Transcranial Focused Ultrasound in Humans Using a Random Array Transducer: A k-Wave Simulation Study

Li, Z.; Yu, K.; Kosnoff, J.; He, B.

10.1101/2025.04.25.650630 — bioengineering — Posted on 2025-04-28

677 Trans-homologous interactions identified in Hi-C data are associated with embryonic development

Machnicka, M. A.; Jankowski, A.

10.1101/2025.04.25.648339 — genomics — Posted on 2025-04-26

678 IN4MER Bioink: A Phosphorescent Biosensing Bio-ink for Multiple Analytes (Glucose, Lactate, Oxygen) Measurements and Temperature Sensing Applications

Saleem, W.; Chimene, D.; White, B. P.; Deo, K. A.; Thomas, J. L.; Chidambara, N.; Mandrona, C.; Landsgaard, K.; Ko, B.; Kaunas, R.; Gaharwar, A. K.; McShane, M. J.

10.1101/2025.04.22.650078 — bioengineering — Posted on 2025-04-29

679 Genome evolution in parthenogenetic nematodes shaped by chromosome rearrangements and rare sex

Chung, G.; Stevens, L.; Dai, X.; Hickey, S.; Kiontke, K.; Rughani, P.; Kieninger, M. R.; Collins, J. C.; Juul, S.; Piano, F.; Fitch, D. H. A.; Blaxter, M.; Gunsalus, K. C.

10.1101/2025.04.24.650375 — genomics — Posted on 2025-04-27

680 Plasmonic imaging of living pancreatic beta-cell networks

Abayzeed, S.; Galvis, D.; Medel, K. R.; Gonzalez, O. B.; Setchfield, K.; Somekh, M. G.; Wedgwood, K. C. A.; Smith, P.

10.1101/2025.04.22.649945 — bioengineering — Posted on 2025-04-29

681 Neighborhood nonnegative matrix factorization identifies patterns and spatially-variable genes in large-scale spatial transcriptomics data

Laursen, R.; Chen, H.; Demaray, J.; Pelka, K.; Engelhardt, B. E.

10.1101/2025.04.26.650724 — genomics — Posted on 2025-04-27

682 Body reconstruction and size estimation of plesiosaurs:enlightenment on the ribcage restoration of extinct amniotes in2D environments

Zhao, R. J.

10.1101/2024.02.15.578844 — paleontology — Posted on 2025-04-28

683 Scalable Culture of Mammalian Cells in RGD Peptide-Modified Alginate Hydrogel Microtubes

Wang, O.; Han, L.; Dong, C.; Xie, L.; Wang, A.; Wang, S.; Lei, Y.

10.1101/2025.04.22.650014 — bioengineering — Posted on 2025-04-29

684 Ancient DNA Reveals Hominoid Evolution: Intermediate DNA Sequences and Advances in Molecular Paleontology

Zhao, L.; Zhang, S.; Guo, Z.; Zhong, Q.; Zheng, Y.; Cai, Y.; Jia, C.; Zhang, S.; Mao, R.; Hong, C.; Wu, M.; Wang, Y.; Zheng, Z.; Zhang, Y.; Jin, Y.; Zhao, W.

10.1101/2025.04.27.650833 — paleontology — Posted on 2025-04-29

685 Chromosome-Specific Aneuploidy Engineering via dCas9-Induced Centromeric Chromatin Relaxation

FENG, H.; Deng, D.; Dahiya, R.; Wang, L.; Zeng, J.; Tan, B. J. Y.; Byrne, F.; Shepherd, S. T. C.; Wang, J.; Johnson, S. C.; Harrod, A.; Lane, K. A.; Fendler, A.; Cattin, A.-L.; Tippu, Z.; Nie, M.; Zhao, Y.; Wang, R.; Ai, W.; Bouricha, O.; Barber, T.; Dovga, Y.; Xu, Y.; Xu, Y.; Devito, L. G.; Healy, L.; Sun, Z.; Shen, W.; Wang, H.; Lim, E. S.; OToole, S. M.; Akker, S.; Drake, W. M.; Jin, H.; Downs, J. A.; McClelland, S. E.; Diffley, J. F. C.; Ly, P.; Turajlic, S.

10.1101/2025.04.25.650684 — genomics — Posted on 2025-04-27

686 In vivo generation of chimeric antigen receptor T cells using optimally retargeted and functionalized lentiviral vectors with reduced immune clearance

Mears, K. S.; Ibrahim, K.; Allen, P. M.; Chinai, J. M.; Avila, O. I.; Muscato, A. J.; Lane-Reticker, S. K.; Rojas, A.; Knudsen, N. H.; Chao, C.-C.; Yates, K. B.; Manguso, R. T.

10.1101/2025.04.23.645810 — bioengineering — Posted on 2025-04-29

687 Genomic in vitro transcription and Nanopore direct RNA sequencing of a human B-Lymphocyte cell line

Tzadikario, T.; Akeson, S.; Esfahani, N. G.; Stein, A.; Choudhary, U.; Amar, K.; Jain, M.

10.1101/2025.04.25.650674 — genomics — Posted on 2025-04-27

688 Intrahost dynamics, together with genetic and phenotypic effects predict the success of viral mutations

Tan, C. C. S.; Escalera-Zamudio, M.; Yavlinsky, A.; van Dorp, L.; Balloux, F.

10.1101/2024.10.18.619070 — genomics — Posted on 2025-04-28

689 Nanopore-Based Whole-Genome Sequencing Reveals a Bioluminescent and Non-Bioluminescent Bacterium Isolated from the Squid Loligo forbesi in the Red Sea.

Hassan, M. A.; Radwan, A. A.; Shawki, H. H.; Khattb, A. E.-N. A.

10.1101/2025.04.27.649427 — genomics — Posted on 2025-04-28

690 Immortalization and Characterization of Schwann Cell Lines Derived from NF1 Associated Cutaneous Neurofibromas

Li, H.; Pemov, A.; Allaway, R. J.; Muir, D. F.; Chang, L.-J.; Banerjee, J.; Scott, A. J.; Nagy, J. M.; Liu, J.; Carrio, M.; Mazuelas, H.; Yachnis, A.; Lee, S. Y.; Zhang, X.; Lyu, Y.; Stewart, D. R.; Hirbe, A.; Blakeley, J. O.; Serra, E.; Wallis, D.; Wallace, M. R.

10.1101/2025.03.19.643702 — genomics — Posted on 2025-04-28

691 Septin7 is essential in early hematopoiesis, but redundant at later stages

Ronkina, N.; Verheyden, N.; Gambhir, P.; Laass, K.; Yakovleva, T.; Doerrie, A.; Abbey, M.; Menon, M. B.; Selich, A.; Galla, M.; Rothe, M.; Schambach, A.; Krueger, A.; Kotlyarov, A.; Gaestel, M.

10.1101/2025.04.22.649981 — biochemistry — Posted on 2025-04-25

692 Early feature extraction drives model performance in high-resolution chromatin accessibility prediction: A systematic evaluation of deep learning architectures

Grover, A.; Muser, T.; Kasak, L.; Zhang, L.; Krymova, E.; Boeva, V.

10.1101/2025.03.01.641000 — genomics — Posted on 2025-04-28

693 Extensive modulation of a conserved cis-regulatory code across 589 grass species

10.1101/2025.04.23.650228 — genomics — Posted on 2025-04-28

694 pH-Controlled Regioselective Rapid Ene-type Reaction (RRER) Enables Bioconjugation of Histone Serotonylation

Wu, J.; Li, H.; Lovato, A.; Symasek, A.; Zheng, Q.

10.1101/2025.04.22.650073 — biochemistry — Posted on 2025-04-25

695 Spatially-resolved molecular sex differences at single cell resolution in the adult human ventromedial and arcuate hypothalamus

Mulvey, B.; Wang, Y.; Divecha, H. R.; Bach, S. V.; Montgomery, K. D.; Cinquemani, S.; Chandra, A.; Du, Y.; Miller, R. A.; Kleinman, J. E.; Page, S. C.; Hyde, T. M.; Martinowich, K.; Hicks, S. C.; Hansen, K. D.; Maynard, K. R.

10.1101/2024.12.07.627362 — genomics — Posted on 2025-04-28

696 Structurally distinct manganese-sensing riboswitch aptamers regulate different expression platform architectures

Stephen, C.; Palmer, D.; Bautista, C.; Mishanina, T.

10.1101/2024.12.14.628514 — biochemistry — Posted on 2025-04-25

697 Optimization of 13C stable isotope labeling for the study of tricarboxylic cycle intermediates in mouse models

Laro, J. A.; Ness, M.; Godinho, J.; Coats, R.; McCall, L.-I.

10.1101/2025.04.22.649802 — biochemistry — Posted on 2025-04-25

698 Passive and active demethylation in immune diseases with proliferation driving global hypomethylation

Shimada, M.; Omae, Y.; Hitomi, Y.; Honda, Y.; Kodama, T.; Honda, M.; Tokunaga, K.; Miyagawa, T.

10.1101/2025.04.25.650620 — genomics — Posted on 2025-04-29

699 Enhanced Identifications and Quantification through Retention Time Down-Sampling in Fast-Cycling diagonal-PASEF Methods

Below, C. R.; Bernhardt, O. M.; Kaspar-Schoenefeld, S.; Willems, S.; Coronado-Barrientos, E.; Karemaker, I. D.; Streckenbach, B.; Raess, L.; Schaer, S.; Trede, D.; Krieger, J. R.; Gandhi, T.; Bruderer, R. M.; Reiter, L.

10.1101/2025.04.23.650190 — biochemistry — Posted on 2025-04-26

700 Single nucleotide polymorphisms and structural variants reveal complex and variable ploidy in the amoebozoan Acanthamoeba castellanii

Colp, M. J.; Archibald, J. M.

10.1101/2025.04.25.650682 — genomics — Posted on 2025-04-29

701 Chip (Ldb1) is a new cofactor of Zelda forming a functional bridge to CBP during zygotic genome activation

Galouzis, C. C.; Kherdjemil, Y.; Forneris, M.; Viales, R. R.; Marco-Ferreres, R.; Furlong, E. E. M.

10.1101/2025.04.24.650404 — genomics — Posted on 2025-04-29

702 Visualisation of translating ribosomes reveals the earliest steps of protein misfolding in human disease

Plessa, E.; Chu, L. P.; Hornby, C. R.; Streit, J. O.; Mitropoulou, A. N.; Chan, S. H. S.; Irving, J. A.; Lomas, D. A.; Christodoulou, J.; Cabrita, L. D.

10.1101/2025.04.25.650147 — biochemistry — Posted on 2025-04-26

703 Manual validation finds only ultra-long long-read sequencing enables faithful, population-level structural variant calling in Drosophila melanogaster euchromatin

Hemker, J. A.; Gellert, H. R.; Smiley-Rhodes, J. A.; Kim, B. Y.; Petrov, D. A.

10.1101/2025.04.21.649852 — genomics — Posted on 2025-04-29

704 Impact of protein degradation and cell growth on mammalian proteomes

Leduc, A.; Zheng, S.; Saxena, P.; Slavov, N.

10.1101/2025.02.10.637566 — biochemistry — Posted on 2025-04-26

705 HaploExplore, first software specifically designed for the detection of minor allele (MiA-) Haploblocks

Manetti, M.; Hiet, S.; Rahmouni, M.; Spadoni, J.-L.; Dobiecki, A.; Lamanda, M.; Tison, M.; Labib, T.; Giuliani, C.; Le Clerc, S.; Zagury, J.-F.

10.1101/2025.04.23.650206 — genomics — Posted on 2025-04-29

706 Nucleic acid sequence determinants oftranscriptional pausing by human mitochondrialRNA polymerase (POLRMT)

Hsieh, A. H.; Mishanina, T. V.

10.1101/2025.04.25.650729 — biochemistry — Posted on 2025-04-26

707 Characterization of nick binding and sealing by LIG1 Huntington's disease-asssociated K845N variant at biochemical, structural, and single-molecule levels

Ratcliffe, J. E.; Balu, K. E.; Chatterjee, S.; Lee, K. M.; Caglayan, M.

10.1101/2025.04.26.650789 — biochemistry — Posted on 2025-04-26

708 Transposons accelerate chromosomal speciation by centromere expansion and chromosome fission

Tai, J.-H.; Wang, T.-Y.; Ma, G.-C.; Wu, Y.-W.; Yu, T.-H.; Wang, C.-F.; Liao, T.-Y.; Huang, S.-P.; Wang, F.-Y.; Terai, Y.; Wu, T.-H.; Hsu, C.-H.; Yu, H.-T.; Shao, K.-T.; Chaw, S.-M.; Wang, H.-Y.

10.1101/2025.02.13.638213 — genomics — Posted on 2025-04-29

709 Single-molecule multimodal timing of in vivo mRNA synthesis

Sethi, A. J.; Guarnacci, M.; Bilal, M.; Krishnan, K. S.; Hayashi, A.; Kanchi, M.; Nojima, T.; Preiss, T.; Eyras, E.; Hayashi, R.

10.1101/2025.04.27.650906 — genomics — Posted on 2025-04-29

710 Systematic evaluation of blood contamination in nanoparticle-based plasma proteomics

Gao, H.; Zhan, Y.; Liu, Y.; Zhu, Z.; Zheng, Y.; Qian, L.; Xue, Z.; Cheng, H.; Nie, Z.; Ge, W.; Ruan, S.; Liu, J.; Zhang, J.; Sun, Y.; Zhou, L.; Xun, D.; Wang, Y.; Xu, H.; Miao, H.; Zhu, Y. J.; Guo, T.

10.1101/2025.04.26.650757 — biochemistry — Posted on 2025-04-26

711 CES1 DEFICIENCY IS ASSOCIATED WITH METABOLIC REPROGRAMING AND ENDOTHELIAL DYSFUNCTION IN PULMONARY ARTERIAL HYPERTENSION

Agarwal, S.; Heo, L.; Chakraborty, A.; Mitra, A.; Liu, L.; Auer, N.; Swaminathan, G.; Huang, F.; Chelladurai, P.; Guardado, E.; Matos, J.; Bankar, A.; Le, C.; West, J.; Suresh, K.; Nair, R. V.; Rabinovitch, M.; Hammock, B. D.; Morisseau, C.; Wu, J. C.; Arany, Z.; Nicolls, M. R.; de Jesus Perez, V. A.

10.1101/2025.04.25.650735 — biochemistry — Posted on 2025-04-26

712 Fluorescence analysis of serum lipoproteins using a histidine-imidazole polyacrylamide slab gel electrophoresis method

Takenaka, Y.; Inoue, I.; Ikeda, M.; Kakinuma, Y.

10.1101/2025.04.26.650752 — biochemistry — Posted on 2025-04-26

713 Enhanced protein precipitation with ammonia enables rapid, universal extraction of oligonucleotides for bioanalysis

Kamali, A.; Shelke, J. D.; Sanford, E. J.; Hayashi, M. M.; Chaisakhon, N.; Kolakowski, R. V.; Puri, S.; Zhang, G.

10.1101/2025.04.24.650521 — biochemistry — Posted on 2025-04-27

714 Engineering NIR-Sighted Bacteria

Meier, S. S. M.; Hörzing, M.; Böhm, C.; Düthorn, E. L. R.; Takala, H.; Uebe, R.; Moeglich, A.

10.1101/2025.04.25.650650 — biochemistry — Posted on 2025-04-27

715 Probing How Anti-Huntingtin Antibodies Bind The Fibrillar Fuzzy Coat Using Solid-State NMR

van der Wel, P. C. A.; Parlato, R.; Lasorsa, A.; Jain, G.

10.1101/2025.04.25.650083 — biochemistry — Posted on 2025-04-27

716 Evidence that genome editing is preferable to transgenesis forenhancing animal traits

Wang, J.

10.1101/2025.04.25.650727 — genetics — Posted on 2025-04-25

717 Spatial control of myosin regulatory light chain phosphorylation modulates cardiac thick filament mechano-sensing

Squarci, C.; Koch, D.; Anaya, P.; Campbell, K.; Kampourakis, T.

10.1101/2025.04.25.650613 — biochemistry — Posted on 2025-04-27

718 Empirical Simulation and In Silico Evaluation of an Ethically Governed, AI-Enhanced CRISPR Prime Editing Framework for TOR1A Mutation Correction in Dystonia

Thiong'o, G. M.; Ogundokun, A.

10.1101/2025.04.22.650096 — genetics — Posted on 2025-04-26

719 Sex-Dependent Responses in Mice to Indomethacin-Induced Injury and Gut Microbiome-Targeted Alleviation

Zhang, J.; Sekela, J. J.; Yang, J.; Sellers, R. S.; Bhatt, A. P.; Redinbo, M. R.

10.1101/2025.04.25.650491 — biochemistry — Posted on 2025-04-27

720 cellSTAAR: Incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of non-coding regions

Van Buren, E.; Zhang, Y.; Li, X.; Selvaraj, M. S.; Li, Z.; Zhou, H.; Palmer, N. D.; Arnett, D. K.; Blangero, J.; Boerwinkle, E.; Cade, B. E.; Carlson, J. C.; Carson, A. P.; Chen, Y.-D. I.; Curran, J.; Duggirala, R.; Fornage, M.; Franceschini, N.; Graff, M.; Gu, C.; Guo, X.; He, J.; Heard-Cosa, N.; Hou, L.; Hung, Y.-J.; Kalyani, R. R.; Kardia, S. L. R.; Kooperberg, C.; Kral, B. G.; Lange, L.; Li, C.; Liu, S.; Lloyd-Jones, D.; Loos, R. J. F.; Manichaikul, A. W.; Martin, L. W.; Mathias, R.; Minster, R.; Mitchell, B. D.; Mychaleckyj, J. C.; Naseri, T.; North, K.; O'Connell, J.; Perry, J. A.; Peyse

10.1101/2025.04.23.650307 — genetics — Posted on 2025-04-26

721 Discovery and characterisation of gene by environment and epistatic genetic effects in a vertebrate model

Welz, B.; Pierotti, S.; Fitzgerald, T. W.; Thumberger, T.; Suzuki, R.; Watson, P.; Fuss, J.; Cordeiro da Trindade, T.; Defranoux, F.; Ferreira, M.; Naruse, K.; Gierten, J.; Loosli, F.; Wittbrodt, J.; Birney, E.

10.1101/2025.04.24.650462 — genetics — Posted on 2025-04-26

722 TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome

von Känel, C.; Aeschlimann, S.; Husova, M.; Oeljeklaus, S.; Stettler, P.; Schnaufer, A.; Warscheid, B.; Zikova, A.; Schneider, A.

10.1101/2025.04.25.650624 — biochemistry — Posted on 2025-04-27

723 Effects of rescaling forward-in-time population genetic simulations

Marsh, J.; Kaushik, S.; Johri, P.

10.1101/2025.04.24.650500 — genetics — Posted on 2025-04-26

724 Metadynamics Simulations for Rational Ligand Design in the Reversible Inhibition of Human Peroxiredoxin 5

Troussicot, L.; Blanc, F. E. C.; Pascal, Y.; Vidal, S.; Lancelin, J.-M.; Guilliere, F.

10.1101/2025.04.25.650576 — biochemistry — Posted on 2025-04-27

725 Behavioral variation across multiple phases of intravenous cocaine self-administration among genetically diverse mouse populations

10.1101/2025.04.23.650259 — genetics — Posted on 2025-04-27

726 The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator

Giandomenico, S. L.; Mueller, M.; van Oostrum, M.; Desch, K.; Krause, B.; Tushev, G.; Ciirdaeva, E.; Langer, J. D.; Alvarez-Castelao, B.; Schuman, E. M.

10.1101/2025.04.25.650603 — biochemistry — Posted on 2025-04-27

727 RNA-coupled CRISPR Screens Reveal ZNF207 as a Regulator of LMNA Aberrant Splicing in Progeria

Behera, A. K.; Kim, J. J.; Kordale, S.; Damodaran, A. P.; Kumari, B.; Vidak, S.; Dickson, E.; Xiao, M.-S.; Duncan, G.; Andersson, T.; Misteli, T.; Gonatopoulos-Pournatzis, T.

10.1101/2025.04.25.648738 — genetics — Posted on 2025-04-27

728 High-throughput chemical proteomics workflow for profiling protein citrullination dynamics

Meelker Gonzalez, R.; Laposchan, S.; Riedel, E.; Fürst, A.; O'Sullivan, N.; Gabriel, W.; Wilhelm, M.; Knolle, P. A.; Medard, G.; Kuster, B.; Lee, C.-Y.

10.1101/2025.04.25.650601 — biochemistry — Posted on 2025-04-27

729 A fractal pattern of hierarchical genetic population structure in mixed stocks across fish segregated by dams revealed by genomic resources for curimba Prochilodus lineatus

Yazbeck, G. M.; Nascimento, G. A. S.; Carvalho, L. C.; Graciano, R. C. D.; Santos, R.; Oliveira, R. S.

10.1101/2025.03.14.643328 — genetics — Posted on 2025-04-27

730 Hierarchical small molecule inhibition of MYST acetyltransferases

Chen, X.; Castroverde, A.; Perez, M.; Holewinksi, R.; Suazo, K. F.; Karki, R.; Andresson, T.; Garcia, B.; Meier, J. L.

10.1101/2025.04.25.650653 — biochemistry — Posted on 2025-04-27

731 Splicing variants in MYRF cause partial loss of function in the retinal pigment epithelium

Rozumek, G. M.; Brinkmeier, M. L.; Guan, B.; Wang, S. Q.; Tower, C.; Yang, N. T.; Lim, R.; Dong, L.; Hannum, D. F.; Moroi, S. E.; Richards, J. E.; Hufnagel, R. B.; Prasov, L.

10.1101/2025.04.21.649840 — genetics — Posted on 2025-04-28

732 Unique Gluing Effect of ASXL1 K351 Monoubiquitination Stimulates PR-DUB-Mediated Nucleosomal H2AK119Ub Deubiquitination

Zhang, T.; Zheng, J.; Tong, Z.; Deng, Z.; He, Z.; Wu, X.; Wang, M.; Du, Y.; Xu, Z.; Tao, S.; Tian, X.; Deng, H.; Pan, M.; Ai, H.; Liu, L.

10.1101/2025.04.25.650627 — biochemistry — Posted on 2025-04-27

733 Interventionally targeting somatic CAG expansions can be a rapid disease-modifying therapeutic avenue: Preclinical evidence.

Gall-Duncan, T.; Ko, S. Y.; Quick, I. K.; Khan, M.; Feng, K.; Kelley, C. P.; Coleman, A.; Touze, A.; Tang, S.; Mehkary, M.; Yokoi, K.; Herrington, C. R.; You, J.; Lambie, S. C.; Prasolava, T. K.; Panigrahi, G. B.; Park, J.; Nakatani, K.; Byrne, L. M.; Wang, P.; Schneekloth, J. S.; Nakamori, M.; Frankland, P. W.; Pearson, C. E.

10.1101/2025.04.25.650652 — genetics — Posted on 2025-04-28

734 Exploring the C(2)M Cohesin Complex: Structure, Dynamics, and Ability to Facilitate Assembly of the Synaptonemal Complex

Howland, M.; Nguyen, H.; Mitri, D.; Mathew, J.; Patel, N.; Gyuricza, M. R.; Jang, J. K.; McKim, K. S.

10.1101/2025.04.21.649846 — genetics — Posted on 2025-04-28

735 One-carbon metabolism enzyme Ahcy is a redox sensor that modulates gene expression to protect against light stress-induced retinal degeneration

Stanhope, S. C.; Singhal, K.; Morato, N. M.; Feng, Y.; Meng, G.; Marlin, M. N.; Kotanko, C. C.; Jarrett, M. M.; Mesecar, A. D.; Cooks, R. G.; Weake, V. M.

10.1101/2025.04.25.650714 — biochemistry — Posted on 2025-04-27

736 Structure of active methyl-CoM reductase, Earth's main methane producer

Ohmer, C. J.; Abernathy, M. J.; Marchany-Rivera, D.; Villareal, D. G.; Simon, P. S.; Lyubimov, A.; Bhowmick, A.; Chatterjee, K.; Makita, H.; Tiwari, V.; Dasgupta, M.; Keable, S.; Mittan-Moreau, D.; Paley, D. W.; Moriarty, N. W.; Sanchez, H.; Rosenberg, D. J.; Gee, L. B.; Alonso-Mori, R.; Sauter, N. K.; Brewster, A. S.; Bergmann, U.; Yachandra, V. K.; Cohen, A. E.; Yano, J.; Kern, J.; Sarangi, R.; Ragsdale, S. W.

10.1101/2025.04.26.650772 — biochemistry — Posted on 2025-04-27

737 Codon-Optimized Base Editors Enable Efficient Base Substitution in Non-model Animals

Wang, J.

10.1101/2025.04.25.650635 — genetics — Posted on 2025-04-29

738 Triple gene disruption confers genetic resistance to infectious salmon anaemia virus in Atlantic salmon (Salmo salar)

Wang, J.

10.1101/2025.04.25.650625 — genetics — Posted on 2025-04-29

739 The temperature dependence of binding entropy is a selective pressure in protein evolution

Georgelin, R.; Bott, H.; Kaczmarski, J.; Frkic, R.; Tan, L. L.; Tokuriki, N.; Spence, M. A.; Jackson, C.

10.1101/2025.03.23.644840 — biochemistry — Posted on 2025-04-28

740 CREPE (CREate Primers and Evaluate): a computational tool for large-scale primer design and specificity analysis

Pitsch, J. W.; Wirth, S. A.; Costantino, N. T.; Mejia, J.; Doss, R. M.; Warren, A. V. A.; Yang, X.; Breuss, M. W.

10.1101/2025.03.28.646040 — genetics — Posted on 2025-04-29

741 Unravelling the Enantioselective Mechanism of Benzylsuccinate Synthase: Insights into Anaerobic Hydrocarbon Degradation Through Multiscale Modelling and Kinetics

Szaleniec, M.; Oleksy, G.; Aleksic, I.; Kramer, K.; Borowski, T.; Heider, J.

10.1101/2024.10.11.617960 — biochemistry — Posted on 2025-04-28

742 Maintenance of polymorphism in spatially heterogeneous environments

Sakamoto, T.; Yeaman, S.

10.1101/2025.04.25.650679 — genetics — Posted on 2025-04-29

743 Bringing the Ends together: Cryo-EM structures of mycobacterial Ku in complex with DNA define its role in NHEJ synapsis

Baral, J.; Ang, C.-S.; McMillan, P.; Shobhana, K.; Hinde, E.; Das, A. K.; Rouiller, I.

10.1101/2025.04.28.650930 — biochemistry — Posted on 2025-04-28

744 Anks3 mediates cilia dependent polycystin signaling and is essential for adult kidney homeostasis

Wei, Z.; Rehman, M.; Gu, J.; Lerner, G.; Dong, K.; Roy, K.; Cordido, A.; Cai, Y.; Tian, X.; Tham, M. S.; Kanyo, J.; Lam, T. T.; Zhao, H.; Somlo, S.

10.1101/2025.04.22.649832 — genetics — Posted on 2025-04-29

745 Identification of uranyl-binding proteins in Arabidopsis thaliana cells exposed to uranium: Insights from a metalloproteomic analysis and characterization of Glycine-Rich RNA-binding Protein 7 (GRP7)

Revel, B. H.; Favier, A.; Martin-Laffon, J.; Vallet, A.; Przybyla-Toscano, J.; Brugiere, S.; Coute, Y.; Diemer, H.; Cianferani, S.; Rabilloud, T.; Bourguignon, J.; Brutscher, B.; Ravanel, S.; Alban, C.

10.1101/2025.04.28.650916 — biochemistry — Posted on 2025-04-28

746 SAM-AMP lyases in CRISPR defence and anti-defence

Chi, H.; McMahon, S.; Daniel-Pedersen, L.; Graham, S.; Gloster, T. M.; White, M. F.

10.1101/2025.04.28.651013 — biochemistry — Posted on 2025-04-28

747 Predicting pose distribution of protein domains connected by flexible linkers is an unsolved problem

McBride, A. C.; Yu, F.; Cheng, E. H.; Mpouli, A.; Soe, A. C.; Hammel, M.; Montelione, G. T.; Oas, T. G.; Tsutakawa, S. E.; Donald, B. R.

10.1101/2025.04.27.650885 — biochemistry — Posted on 2025-04-28

748 Azadiradione regulates Heat Shock Factor 1 function by interacting with its DNA-binding domain independent of the oligomerization domain

Manna, A.; Basak, P.; MAJUMDER, C.; Hazra, N.; Jana, K.; Mukhopadhyay, J.; Mandal, S. C.; Pal, M.

10.1101/2025.04.28.650926 — biochemistry — Posted on 2025-04-28

749 GTEx_Pro: A robust and accurate preprocessing pipeline for GTEx data: TMM+CPM normalization and SVA batch correction for enhanced multi-tissue analysis

Jothi, D.

10.1101/2025.04.26.650748 — biochemistry — Posted on 2025-04-29

750 DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders

Orr, L. M.; Tomlinson, S. J.; Grupe, H. R.; Lim, M.; Ho, E.; Yilmaz, H.; Zhou, G.; Leon, B.; Olzmann, J. A.; Nomura, D. K.

10.1101/2025.04.25.650514 — biochemistry — Posted on 2025-04-29

751 Ebselen protects XPC deficient cells through a potentially mitohormetic mechanism

Freire, T. S.; Martins, M. S.; Sima, N.; de Souza-Pinto, N. C.

10.1101/2025.04.22.650012 — biochemistry — Posted on 2025-04-29

752 Increased rates of hybridization in swordtail fish are associated with water pollution

Moran, B. M.; Ramirez-Duarte, W. F.; Powell, D. L.; Yang, T. T.; Gunn, T. R.; Jofre-Rodriguez, G. I.; Payne, C. Y.; Iverson, E. N.; Preising, G. E.; Banerjee, S. M.; Donny, A. E.; Sood, R.; Baczenas, J. J.; Vazquez Adame, G. M.; Gutierrez-Rodriguez, C.; Rochman, C. M.; Schumer, M.; Rosenthal, G. G.

10.1101/2025.04.22.649978 — evolutionary biology — Posted on 2025-04-26

753 Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain

Taber, C. C.; He, W.; Gasmi-Seabrook, G. M. C.; Hubert, M.; Ferens, F. G.; Ikura, M.; Lee, J. E.; Ohh, M.

10.1101/2025.04.22.650142 — biochemistry — Posted on 2025-04-29

754 State Space Misspecification in Morphological Phylogenetics: A Pitfall for Models and Parsimony Alike

Huang, E.

10.1101/2025.04.22.650124 — evolutionary biology — Posted on 2025-04-26

755 A re-evaluation of Muller's sheltering hypothesis for the evolution of sex chromosome gene content

Mrnjavac, A.; Vicoso, B.; Connallon, T.

10.1101/2025.04.24.650552 — evolutionary biology — Posted on 2025-04-26

756 Emergence of a Cell-Guided Multivalent Ligand of Enzymes on Cancer Cells Triggered by Click Reaction between Hetero Nano-Assemblies

Sakamoto, R.; Koba, Y.; Nakamoto, M.; Fukuta, T.; Kadota, K.; Matsusaki, M.

10.1101/2025.04.24.649770 — biochemistry — Posted on 2025-04-29

757 Gene drive dynamics in plants: the role of seedbanks

Kim, I. K.; Tian, L.; Chaffee, R.; Haller, B. C.; Champer, J.; Messer, P. W.; Kim, J.

10.1101/2025.04.24.649389 — evolutionary biology — Posted on 2025-04-26

758 Fabrication of microcompartments with controlled size and shape for encapsulating active matter

Vianay, B.; Guerin, C.; Gressin, L.; Orhant-Prioux, M.; Blanchoin, L.; Thery, M.; Colin, A.

10.1101/2025.04.23.650156 — biochemistry — Posted on 2025-04-29

759 From head to tail: does habitat use drive morphological variation in snakes?

Hudry, D.; Herrel, A.

10.1101/2025.04.25.648294 — evolutionary biology — Posted on 2025-04-26

760 Stereochemical Insights into Sarpagan and Akuammiline Alkaloid Biosynthesis

Mann, S. G. A.; Paz-Galeano, M.; Shahsavarani, M.; Perley, J. O.; Guo, J.; Garza-Garcia, J. J. O.; Qu, Y.

10.1101/2024.12.19.629490 — biochemistry — Posted on 2025-04-29

761 Timing the initiation of sex: Delay mechanisms alter fitness outcomes in a rotifer population model

Stevens, B. L. F.; van Daalen, S. F.; Blomquist, T. J.; Gribble, K. E.; Neubert, M. G.

10.1101/2025.04.25.650506 — evolutionary biology — Posted on 2025-04-26

762 Proteomic study for the prediction of μCT imaging with iodine

Wesp, V.; Barf, L.-M.; Stark, H.

10.1101/2025.04.22.649994 — biochemistry — Posted on 2025-04-29

763 Hybrid incompatibility emerges at the one-cell stage in interspecies Caenorhabditis embryos

Bloom, J.; Green, R. A.; Desai, A.; Oegema, K.; Rifkin, S. A.

10.1101/2024.10.19.619171 — evolutionary biology — Posted on 2025-04-27

764 Tentative evidence that aging is caused by a small number of interacting processes

Kowald, A.; Kirkwood, T. B. L.

10.1101/2025.04.22.649947 — biochemistry — Posted on 2025-04-29

765 The kinase domain of RIPK3 tunes its scaffolding functions

Chiou, S.; Patel, K. M.; Preaudet, A.; Rickard, J. A.; Horne, C. R.; Young, S. N.; Garnish, S. E.; Hempel, A.; Hall, C.; Hildebrand, J.; Kueh, A. J.; Putoczki, T. L.; Hawkins, E. D.; Samson, A. L.; Murphy, J. M.

10.1101/2025.04.29.651198 — biochemistry — Posted on 2025-04-29

766 Computer Simulations and Analyses of Coupling Among Reproductive Barriers in Late-Stage Sympatric Speciation

Lin, J.; Sultana, Z.; Heyda, C.; Gieck, L.; Lin, J.

10.1101/2025.04.21.649836 — evolutionary biology — Posted on 2025-04-28

767 Genealogical analysis of replicate flower colour hybrid zones in Antirrhinum

Pal, A.; Shipilina, D.; Moan, A. L.; McNairn, A. J.; Grenier, J. K.; Kucka, M.; Coop, G.; Chan, Y. F.; Barton, N. H.; Field, D.; Stankowski, S.

10.1101/2025.04.27.649910 — evolutionary biology — Posted on 2025-04-28

768 Evidence that human skill level is more reactive to developmental history than to genes or environment

Gonzalez-Forero, M.; Gomez-Robles, A.

10.1101/2025.03.17.643651 — evolutionary biology — Posted on 2025-04-28

769 Detecting cryptic ghost lineage introgression in four-taxon genomic datasets

Forsythe, E. S.; Pappa, B. S.; Clavette, D. A.; Mendoza, D. Y.

10.1101/2025.04.28.651118 — evolutionary biology — Posted on 2025-04-29

770 BABAPPA: An Automated Pipeline for Codeml Mediated Selection Analysis Integrating PRANK and IQ-TREE2

Sinha, K.

10.1101/2025.04.27.650835 — evolutionary biology — Posted on 2025-04-29

771 Speed Matters: Accelerated Pharmacokinetics Reduce Persisters in Escherichia coli

Ali, K. M.; Murphy, R.; Zanchi, C.; Zunk-Parras, S. A.; Rodriguez-Rojas, A.; Rolff, J.

10.1101/2025.04.25.650648 — evolutionary biology — Posted on 2025-04-29

772 Recently evolved, stage-specific genes are enriched at life stage transitions in flies

Remmel, A.; Kaether, K.-K.; Stadler, P. F.; Lemke, S.

10.1101/2025.04.28.650992 — evolutionary biology — Posted on 2025-04-29

773 Motor deficits in the McGill-R-Thy1-APP transgenic rat model of Alzheimers Disease

Roddick, K.; Schellinck, H. M.; Brown, R. E.

10.1101/2025.04.24.650385 — animal behavior and cognition — Posted on 2025-04-26

774 Proteomic characterisation of Japanese quails unique seminal foam

Mason, C.; Garlovsky, M.; Vedder, O.; Pham, T. K.; George, R.; Tschirren, B.; Hemmings, N.

10.1101/2025.04.23.650219 — evolutionary biology — Posted on 2025-04-29

775 Peering into the world of wild passerines with 3D-SOCS: synchronized video capture and posture estimation

Chimento, M.; Chan, A. H. H.; Aplin, L. M.; Kano, F.

10.1101/2024.06.30.601375 — animal behavior and cognition — Posted on 2025-04-26

776 Increased clonality, decreased allele diversity and high genetic structure in tetraploid sea anemone Aulactinia stella populations from North Pacific to Atlantic across the Arctic Ocean

Bocharova, E.; Volkov, A.; Stoeckel, S.

10.1101/2025.04.24.650399 — evolutionary biology — Posted on 2025-04-29

777 Random and non-random variation in flower color along an urban-rural gradient in the introduced mustard Hesperis matronalis

Maunder, K. G.; Dawson, K.; Joslin, L.; Eckert, L.; Kraml, M. M.; Dean-Moore, C.; Eckert, C. G.

10.1101/2025.04.22.650098 — evolutionary biology — Posted on 2025-04-29

778 Neural dynamics of emergent social roles in collective foraging by mice

Lee, J.; Lee, G.-H.; Kim, S.; Jung, D.; Kim, J.; Choi, J. H.

10.1101/2025.04.24.650547 — animal behavior and cognition — Posted on 2025-04-26

779 Dissecting Cold Tolerance in Drosophila ananassae: A Multi-Phenotypic and Bulk Segregant Analysis

Yılmaz, V. M.; Kara, F. T.; Grath, S.

10.1101/2025.04.23.650207 — evolutionary biology — Posted on 2025-04-29

780 Motor deficits in the McGill-R-Thy1-APP transgenic rat model of Alzheimer's Disease

Roddick, K.; Schellinck, H. M.; Brown, R. E.

10.1101/2025.04.24.650385 — animal behavior and cognition — Posted on 2025-04-26

781 Joint estimation of paternity, sibships and pollen dispersal in a snapdragon hybrid zone

Ellis, T. J.; Field, D. L.; Barton, N. H.

10.1101/2024.01.05.574354 — evolutionary biology — Posted on 2025-04-29

782 Asian elephants (Elephas maximus) recognise human visual attention from body and face orientation

Jim, H.-L.; Yamamoto, S.; Bansiddhi, P.; Plotnik, J. M.

10.1101/2025.04.27.650167 — animal behavior and cognition — Posted on 2025-04-27

783 Tissue heterogeneity is associated with phenotypic but not genomic diversity in Wolbachia endosymbionts

Pigeault, R.; Dussert, Y.; Jorge, R.; Ulve, T.; Panza, M.; Raimond, M.; Delaunay, C.; Aucher, W.; Berges, T.; Ogereau, D.; Moumen, B.; Peccoud, J.; Cordaux, R.

10.1101/2024.06.20.599863 — evolutionary biology — Posted on 2025-04-29

784 Dogs' behaviour is more similar to that of children than to that of cats in a prosocial problem situation

Csepregi, M.; Moravcsik, A. A.; Miklosi, A.; Gacsi, M.

10.1101/2025.04.27.650646 — animal behavior and cognition — Posted on 2025-04-27

785 Age-related Inhibitory Decline: Examining Inhibition Sub-Components and their Impact on Sustained Attention in Healthy Ageing

Treacy, C.; Andrews, S. C.; Levenstein, J. M.

10.1101/2025.02.19.638971 — animal behavior and cognition — Posted on 2025-04-28

786 Testing bottom-up cuing effects on target detection and discrimination in Bumblebees

Robert, T.; Callendret, M.; Sowels, C.; Nityananda, V.

10.1101/2025.04.23.650250 — animal behavior and cognition — Posted on 2025-04-28

787 A Novel Microsurgical Rat Model of Cervical Lymph Node-to-Vein Anastomosis (LNVA) for Studying Brain Lymphatic Outflow

Fang, R.; Jin, L.; Lu, H.; Xie, Q.; Yang, X.; Kueckelhaus, M.

10.1101/2025.03.15.643475 — animal behavior and cognition — Posted on 2025-04-29

788 Prolonged exposure treatment following chronic social defeat stress in mice reduces behavioral stress responses and social avoidance.

Kim, J.; Kim, C. S.

10.1101/2025.04.28.651027 — animal behavior and cognition — Posted on 2025-04-29

789 To Peck or Not To Peck: The influence of early-life social environment on response inhibition and impulsive aggression in Japanese quails

Vernouillet, A.; Willcox, K.; Allaert, R.; Dewulf, A.; Zhang, W.; Troisi, C. A.; Knoch, S.; Martel, A.; Lens, L.; Verbruggen, F.

10.1101/2024.12.20.629368 — animal behavior and cognition — Posted on 2025-04-29

790 Detecting infection-related mortality using dynamical statistical indicators of high-resolution activity time series

Kutzer, M. A. M.; Abdullateef, S.; Cano, A. V.; Soare-Nguyen, I. L.; Montieth, K. M.; Escudero, J.; Dakos, V.; Vale, P. F.

10.1101/2025.04.21.649753 — ecology — Posted on 2025-04-25

791 Cognitive strategy accounts for failure on a hippocampal relational memory task in non-human primates

Vanderlip, C. R.; Dunn, S. R.; Asch, P. A.; Glavis-Bloom, C.

10.1101/2025.04.23.650325 — animal behavior and cognition — Posted on 2025-04-29

792 Host genetics and the Skin Microbiome Independently Predict Parasite Resistance

Kramp, R. D.; Janecka, M.; Tardent, N.; Jokela, J.; Kohl, K. D.; Stephenson, J. F.

10.1101/2024.10.19.619196 — ecology — Posted on 2025-04-25

793 Big Data, Sound Science, Lasting Impact: a framework for passive acoustic monitoring

Wall, C. C.; McKenna, M.; Hatch, L. T.; Van Parijs, S. M.; Bochenek, R.; Dugan, P.; Parcerisas, C.; Ryan, J.; Anderson, C. D.; Becker, K.; Berchok, C.; Biddle, M.; Boebel, O.; Canino, A.; Canonico, G.; Cline, D.; Davis, G. E.; Frasier, K.; Gedamke, J.; Haver, S. M.; Khazmutdinova, K.; Kinneging, N.; Kumar, A.; Marian, A.; Miksis-Olds, J.; Montie, E. W.; Ponirakis, D.; Rice, A. N.; Rowell, T. J.; Rueda, C.; Shumchenia, E.; Shyka, T.; Staaterman, E.; Thomisch, K.

10.1101/2025.04.22.650104 — ecology — Posted on 2025-04-26

794 Ecological Toxicity Effects of Marine Pollutants Based on Microalgal Locomotory Behavior

Xie, Z.; Wang, L.; Zheng, G.

10.1101/2025.04.23.650213 — ecology — Posted on 2025-04-26

795 What makes a society dead: accumulation of uric acid increases infectious disease risk in termites

Konishi, T.; Nakashima, M.; Nozaki, T.; Tasaki, E.; Takata, M.; Matsuura, K.

10.1101/2025.04.23.650172 — ecology — Posted on 2025-04-26

796 Environmental heterogeneity plays a bigger role than diet quality in driving divergent California sea lion population trends

Pozas Franco, A. L.; ROSEN, D. A. S.; Trites, A. W.; Hernandez-Camacho, C. J.; Garcia-Rodriguez, F. J.

10.1101/2025.04.23.650199 — ecology — Posted on 2025-04-26

797 Plant species and floral traits shape arthropod communities in restored prairies more than neonicotinoid contamination

Tetlie, J.; Harmon-Threatt, A.

10.1101/2025.04.23.650261 — ecology — Posted on 2025-04-26

798 Estimating dead fish quantities dropping out of gillnets when direct observations are impossible.

Benoit, H.; Chamberland, J.-M.; Allard, J.

10.1101/2025.04.23.650286 — ecology — Posted on 2025-04-26

799 Long term hybrid zone dynamics in red- and yellow-bellied toads estimated from environmental data at allopatric and parapatric scales

Arntzen, J. W.

10.1101/2025.04.24.650419 — ecology — Posted on 2025-04-26

800 Tree Growth, Contraction, and Recovery: Disentangling Soil and Atmospheric Drought Effects

Feuer, E.; Preisler, Y.; Rotenberg, E.; Yakir, D.; Mau, Y.

10.1101/2025.04.24.650406 — ecology — Posted on 2025-04-26

801 Quantifying the net effect of biodiversity on stability

Kunze, C.; Bahlburg, D.; Striebel, M.; Schott, T.; Donohue, I.; Hillebrand, H.

10.1101/2025.04.24.650410 — ecology — Posted on 2025-04-26

802 Hidden Diversity of Threatened Sharks and Rays in the Global Meat Trade

MacNeil, M. A.; Mull, C.; Martins, A.; Babcock, E.; Tyabji, Z.; Andorra, A.; Clarke, S.; Jabado, R.; Sant, G.; Cinner, J.; Gephart, J.; Dulvy, N.; Oakley-Cogan, A.; Kasana, D.; Warwick, L.; Simpfendorfer, C.; Fowler, S.; de Araujo Freire, M.; Bariche, M.; Beaufort, O.; Bizzarro, J.; del Pilar Blanco, M.; Braccini, M.; Barullio de Luna Sales, J.; Bustamante, C.; Carlson, J.; Charvet, P.; Cuevas, J.; Fernandes, C.; Fernando, D.; Finucci, B.; Garcia Rodriguez, E.; Gonzalez-Pestana, A.; Cardoso, L.; Hauser-Davis, R.; Muttaqin, E.; Polo-Silva, C.; Ready, J.; Ruiz-Garcia, D.; Saldana Ruiz, L.; Seidu

10.1101/2025.04.24.650194 — ecology — Posted on 2025-04-26

803 Rapid sexual reproduction in a mixotrophic dinoflagellate revealed through temporal partitioning of cellular processes

Sung-Clarke, S.; Ayache, N.; Zhang, W.; Tong, M.; Smith, J.; Brosnahan, M.

10.1101/2025.04.24.649572 — ecology — Posted on 2025-04-26

804 Assessment of environmental variables for species distribution modelling: insights from the mosaic distribution of red- and yellow-bellied toads

Arntzen, J. W.; Harmos, K.; Voros, J.

10.1101/2025.04.24.650429 — ecology — Posted on 2025-04-26

805 Consistent covariation of dispersal, life history and thermal niches across terrestrial arthropods

Logghe, G.; Batsleer, F.; Fandos, G.; Maes, D.; Bonte, D.

10.1101/2025.01.10.632369 — ecology — Posted on 2025-04-27

806 Global Stability and Tipping Point Prediction in a Coral-Algae Model Using Landscape-Flux Theory

Xu, L.; Patterson, D.; Levin, S. A.; Wang, J.

10.1101/2024.12.17.627631 — ecology — Posted on 2025-04-28

807 Genome scale metabolic modelling of human gut microbes to inform rational community design

Ortiz, J. P. M.; McClure, D. D.; Holmes, A.; Rice, S. A.; Read, M. N.; Shanahan, E. R.

10.1101/2024.05.28.596116 — ecology — Posted on 2025-04-28

808 On the quest for novelty in ecology

Ottaviani, G.; Martinez, A.; Petit Bon, M.; Mammola, S.

10.1101/2023.02.27.530333 — ecology — Posted on 2025-04-28

809 A theoretical framework linking the effective number of breeders to demographic stochasticity in iteroparous species

Akita, T.

10.1101/2024.06.05.597532 — ecology — Posted on 2025-04-28

810 Trait-environment interactions influence tree planting success in Peruvian tropical dry forests

Goossens, W.; Fremout, T.; Muys, B.; Soto Quispe, J. C.; Van Meerbeek, K.; Maes, S. L.

10.1101/2025.02.21.639418 — ecology — Posted on 2025-04-28

811 Long-term effects of early-life adversity on DNA methylation in zebra finches

Tangili, M.; Jimeno, B.; Briga, M.; Palsboll, P. J.; Verhulst, S.

10.1101/2025.04.23.649997 — ecology — Posted on 2025-04-28

812 Unfeasible expectations: why simple predictors outperform structural stability measures for understanding community assembly

Terry, C.

10.1101/2025.04.24.650476 — ecology — Posted on 2025-04-28

813 Differential regulation of apoptosis, autophagy and Symbiodiniaceae energy transfer mediate the link between bleaching and disease in Exaiptasia diaphana

Diaz de Villegas, S. C.; Abdelbaki, P. Y.; Fuess, L. E.

10.1101/2025.04.21.649845 — ecology — Posted on 2025-04-28

814 Symbiotic solutions for colony nutrition: conserved nitrogen recycling within the bacterial pouch of Tetraponera ants

Ma, M.; Zhu, B.; Zhang, D.; Lukasik, P.; Hu, Y.

10.1101/2025.03.13.643113 — ecology — Posted on 2025-04-28

815 Highly Dynamic Population of Owned Dogs and Implications for Zoonosis Control

Diaz, E. W.; Sila, S.; Raynor, B. B.; De la Puente-Leon, M.; Levy, M. Z.; Castillo-Neyra, R.

10.1101/2025.04.23.650047 — ecology — Posted on 2025-04-28

816 Fitness effects of adult crowding in Drosophila: more than just overall density

Rao, M.; Temura, C.; Bindya, R. S.; Joshi, A.

10.1101/2025.04.24.650416 — ecology — Posted on 2025-04-29

817 Forest biogeochemical monitoring indicates altered microbial communities, macronutrient availability, CO2 emissions and litter chemistry in root zone soil of oak trees with Acute Decline symptoms

Dhandapani, S.; McNeil, T.; Lu, B.; Booth, O.; Corbett, L.; Lunn, J.; Nightingale, A.; Niu, X.; Roose, T.; John, J.; Lin, H.; Adekanmbi, A. A.; Shaw, L. J.

10.1101/2025.04.22.650028 — ecology — Posted on 2025-04-29

818 On the edge of extinction: Delayed plant genetic response to forest edge dynamics

Hostens, L.; Metsu, C.; Van Acker, K.; Peeters, G.; de Beer, S.; Gansemans, Y.; Kupcinskiene, E.; Jociene, L.; Krokaite-Kudakiene, E.; Paulssen, J.; Mazalla, L.; Diekmann, M.; Conradi, T.; Plössner, S.; Deak, B.; Valko, O.; Fekete, R.; Orczewska, A.; Hedwall, P.-O.; Brunet, J.; Huang, S.; Feigs, J. T.; Naaf, T.; Wulf, M.; Plue, J.; Liira, J.; Deforce, D.; Van Nieuwerburgh, F.; De Frenne, P.; Vandelook, F.; Van Meerbeek, K.; Honnay, O.; De Kort, H.

10.1101/2025.04.23.649530 — ecology — Posted on 2025-04-29

819 Abrupt versus gradual application of pesticides: effects on soil bacterial and fungal communities

Riedo, J.; Duenas, J. F.; Mbedi, S.; Sparmann, S.; Rillig, M. C.

10.1101/2025.03.24.644867 — ecology — Posted on 2025-04-29

820 Mitochondrial iron transport via MFRN1 is required for erythroid cell cycle progression

Perfetto, M.; Danoff, A.; Ishfaq, M.; Monroe, H.; Mohideen, A.; Chen, M.; Stratman, A. N.; Okawa, S.; Yien, Y. Y.

10.1101/2022.08.22.504833 — developmental biology — Posted on 2025-04-25

821 NSD2 links developmental plasticity to mitochondrial function in muscle and lymphocyte differentiation

Martinez-Cano, J.; Sagrera, A.; Estrada, B. S.; Cogliati, S.; Martinez-Martin, N.; Cobaleda, C.

10.1101/2025.04.26.648922 — developmental biology — Posted on 2025-04-26

822 Life-cycle-related gene expression patterns in the brown algae

Ratchinski, P.; Godfroy, O.; Noel, B.; Aury, J.-M.; Cock, J. M.

10.1101/2025.04.25.649966 — developmental biology — Posted on 2025-04-26

823 Embryonic Durotaxis: A Mechanical Framework for Understanding Cesarean Scar Pregnancy

Cao, J.; You, H.; Li, J.; Yue, S.; Song, B.; Li, H.; Wei, J.; Guan, D.; Zu, Y.; Zheng, X.; Wang, Y.; Fan, Y.; Du, J.

10.1101/2025.04.24.650347 — developmental biology — Posted on 2025-04-26

824 Integrin promotes basement membrane crossing and branching of an invading intracellular tube

Meyer, L. N.; Hertel, M.; Nance, J.

10.1101/2025.04.24.650450 — developmental biology — Posted on 2025-04-26

825 Global maps of transcription factor properties reveal threshold-based formation of DNA-bound and mobile clusters

Dima, S. S.; Turner, M. A.; Garcia, H. G.; Reeves, G. T.

10.1101/2025.04.24.650477 — developmental biology — Posted on 2025-04-27

826 Inhibiting SOX18 with propranolol restores vascular integrity in NR2F2-driven malformations

Graus, M. S.; Jha, S. K.; Lou, J.; Holm, A.; Wong, Y. Y.; Davidson, T.; Coleman, P.; Sugo, E.; Luu, W.; Karnezis, T.; Gamble, J.; McCaughan, G.; Nightingale, S.; Bischoff, J.; Maruyama, K.; Hinde, E.; Red-Horse, K.; Francois, M.

10.1101/2025.04.25.650344 — developmental biology — Posted on 2025-04-27

827 Planar cell polarity signaling controls cell division symmetry to promote termination of adult tissue regeneration

Hack, S. J.; Beane, W. S.

10.1101/2025.04.27.650884 — developmental biology — Posted on 2025-04-28

828 p63 co-opts the skin Krt8-to-Krt5 transition for enamel organ development

Tang, Q.; Lee, J.-M.; Li, L.; Cai, C.; Jung, H.; Kwon, H.-J.

10.1101/2025.02.11.637463 — developmental biology — Posted on 2025-04-28

829 ImplantoMetrics - Multidimensional trophoblast invasion assessment by combining 3D-in-vitro modeling and deep learning analysis

Gyunesh, A. A.; Rezk-Fuereder, M.; Kapper, C.; Mor, G.; Shebl, O.; Oppelt, P.; Stelzl, P.; Arbeithuber, B.

10.1101/2025.04.25.650556 — developmental biology — Posted on 2025-04-28

830 A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the Drosophila Ventral Nerve Cord.

Soffers, J. H.; Beck, E.; Sytkowski, D. J.; Maughan, M. E.; Devarakonda, D.; Zhu, Y.; Wilson, B.; David Chen, Y.-C.; Erclik, T.; Truman, J. W.; Skeath, J. B.; Lacin, H.

10.1101/2024.11.27.625713 — developmental biology — Posted on 2025-04-28

831 Signaling scaffold Shoc2 regulates lymphangiogenesis by suppressing mTORC1-mediated IFN responses.

Wilson, P.; Vishwakarma, V.; Norcross, R.; Khaire, K. S.; Pham, V. N.; Jung, H. M.; Weinstein, B. M.; Galperin, E.

10.1101/2025.03.26.645567 — developmental biology — Posted on 2025-04-28

832 TCA cycle rewiring underpins implantation and histone acetylation programming

Kafkia, E.; Pladevall-Morera, D.; Argemi-Muntadas, L.; Wang, G.; Noberini, R.; Bages-Arnal, S.; Anagho-Mattanovich, M.; Silverio-Alves, R.; Bonaldi, T.; Rabelink, T. J. J.; Moritz, T.; Zylicz, J. J.

10.1101/2025.04.25.650409 — developmental biology — Posted on 2025-04-28

833 SoxB1 family members inhibit Wnt signaling to promote maturation and deposition of stable neuromasts by the zebrafish Posterior Lateral Line primordium

Palardy, G.; Yoo, K.-w.; Fatma, S.; Mukherjee, A.; Wang, C.; Ravi, P.; Chitnis, A. B.

10.1101/2025.04.23.650055 — developmental biology — Posted on 2025-04-28

834 Characterisation of spinal ligaments in the embryonic chick

Hennigan, S.; Talak Basturkmen, E.; Rolfe, R. A.

10.1101/2025.04.22.650009 — developmental biology — Posted on 2025-04-29

835 Interactions between the Bone Morphogenetic Protein and the Planar Cell Polarity Pathways lead to distinctive ethanol-induced facial defects

Gray, R.; Llyod, A.; Lovely, C. B.

10.1101/2025.04.23.650288 — developmental biology — Posted on 2025-04-29

836 Brain dopamine imbalance causes follicle death and underlies negative effect of high sugar diet during Drosophila oogenesis

Nunes, R. D.; Drummond-Barbosa, D.

10.1101/2025.04.25.650701 — developmental biology — Posted on 2025-04-29

837 Life-cycle-related gene expression patterns in the brown algae

Ratchinski, P.; Godfroy, O.; Noel, B.; Aury, J.-M.; Cock, J. M.

10.1101/2025.04.25.649966 — developmental biology — Posted on 2025-04-29

838 JNK MAPK Regulates IFN-Stimulated Genes and Cell Adhesion in Chemoresistant, Quiescent Leukemic Cells

Lee, S.; Baradar, A. A.; Buitrago, P. A. S.; Puente, E.; Kilinc, Z.; Cox, O.; Vasudevan, S.

10.1101/689570 — cell biology — Posted on 2025-04-25

839 High-throughput DNA repair monitoring in Saccharomyces cerevisiae reveals SSB- and DSB-induced chromatin reconfiguration

Shalev Ezra, Y.; Saguy, A.; Levin, G.; Weiss, L. E.; Alalouf, O.; Shechtman, Y.

10.1101/2024.08.23.609327 — cell biology — Posted on 2025-04-27

840 Human formin FHOD3-mediated actin elongation is required for sarcomere integrity in cardiomyocytes

Valencia, D. A.; Koeberlein, A. N.; Nakano, H.; Rudas, A.; Patel, A. A.; Harui, A.; Spencer, C.; Nakano, A.; Quinlan, M. E.

10.1101/2024.10.13.618125 — cell biology — Posted on 2025-04-27

841 The biophysical mechanism of mitochondrial pearling

Sturm, G.; Hake, K.; Lefebvre, A. E. Y. T.; Rux, C. J.; Ivanova, D.; Millett-Sikking, A.; Tharp, K. M.; Rao, B.; Closser, M.; Waite, A. J.; Precido-Lopez, M.; Ritter, A. T.; Dumont, S.; Lu, W.; Manley, S.; Landoni, J. C.; Marshall, W. F.

10.1101/2024.12.21.629509 — cell biology — Posted on 2025-04-27

842 Diabetes-associated MYT1 and MYT3 regulate human beta-cell insulin secretion and survival via other diabetes-risk genes

Hu, R.; Yagan, M.; Wang, Y.; Tong, X.; Hamilton, N.; Doss, T.; Liu, J.-H.; Xu, Y.; Simmons, A.; Lau, K.; stein, r.; Kaverina, I.; Coate, K. C.; Liu, Q.; Gu, G.

10.1101/2025.02.24.639737 — cell biology — Posted on 2025-04-27

843 Muscle regeneration can be rescued in a telomerase deficient zebrafish model of ageing by MMP inhibition

Yuan, Y.; Dyer, C.; Knight, R. D.

10.1101/2025.04.25.650659 — cell biology — Posted on 2025-04-28

844 Mitochondrial Dysfunction Induces Hepatic Lipid Accumulation and Inflammatory Responses in mtDNA Mutator Mice

Ross, J. M.; Kim, A.; Berthod, K.; Mamede-Branca, R.; Olin, M.; Pichardo-Casas, I.; Lehtio, J.; Bjorkhem, I.; Sinclair, D. A.; Olson, L.; Coppotelli, G.

10.1101/2025.04.25.650453 — cell biology — Posted on 2025-04-28

845 Mono-Ubiquitylation-Dependent Rap2 Activation Regulates Lamellipodia Dynamics During Cell Migration

Neumann, A. N. J.; Sampath, r.; Mayerhofer, E.; Mikalayeva, V.; Skeberdis, V. A.; Sarapiniene, I.; Prekeris, R.

10.1101/2025.04.25.650668 — cell biology — Posted on 2025-04-28

846 Outer Kinetochore Proteins form Linear Elements to Regulate Vesicle Transport

Kowaleski, S. J.; Bridgewater, A.; Saraceno, C.; Dudek, M.; Pelisch, F.; Bembenek, J.

10.1101/2025.04.25.650656 — cell biology — Posted on 2025-04-28

847 Condensation of Sidekick at tricellular junctions organizes mechanical forces for cell-cell adhesion remodeling

Uechi, H.; Sun, D.; Saeki, Y.; Hiraiwa, T.; Honigmann, A.; Hyman, A. A.; Kuranaga, E.

10.1101/2025.04.25.650632 — cell biology — Posted on 2025-04-28

848 The V-ATPase/ATG16L1 axis drives membrane remodeling during epithelial morphogenesis

Baonza, G.; Alfonso, T.; Herranz, G.; Quintana-Quintana, C.; Gordillo-Vazquez, C.; El Mazjoub, Y.; Escudero, L. M.; Miguez, D. G.; Marti, E.; Martinez-Martin, N.; Martin-Belmonte, F.

10.1101/2025.04.28.650675 — cell biology — Posted on 2025-04-28

849 Deep Learning-coupled Proximity Proteomics to Deconvolve Kinase Signaling In Vivo

Jha, K.; Shonai, D.; Parekh, A.; Uezu, A.; Fugiyama, T.; Yamamoto, H.; Parameswaran, P.; Yanagisawa, M.; Singh, R.; Soderling, S. H.

10.1101/2025.04.27.650849 — cell biology — Posted on 2025-04-28

850 Mitotic phosphorylation of Lamin B1 rod domain by ULK1 and Aurora A/PLK1 promotes spindle function.

Mendiburo, M. J.; Kalus, C.; Berleth, N.; Berning, L.; Sun, Y.; Hu, Z.; Shahba, A.; Naren, P.; Kasof, G.; Dengjel, J.; Stork, B.

10.1101/2025.04.25.650690 — cell biology — Posted on 2025-04-28

851 SSNA1 organizes the distal luminal centriolar network and promotes ciliogenesis without microtubule association

Huang, Y.-C.; Chong, X.-J.; Chang, T.-J. B.; van Grinsven, E.; Chen, W.-J.; Hsu, W.-B.; Beekman, J. M.; Tang, T. K.; Akhmanova, A.; Yang, T. T.; Wei, J.-H.

10.1101/2025.04.28.648957 — cell biology — Posted on 2025-04-28

852 Novel Fatigue Profiling Approach Highlights Temporal Dynamics of Human Sperm Motility

Sergounioti, A.; Alonaris, E.; Rigas, D.

10.1101/2025.04.27.650828 — cell biology — Posted on 2025-04-28

853 Fucoidans are senotherapeutics that enhance SIRT6-dependent DNA repair

Zhang, L. J.; Elsallabi, O.; Soto-Palma, C.; Bartz, J.; Salekeen, R.; Nunes, A.; Xu, W.; Lee, K.; Hughes, B.; Zhang, B.; Mohamed, A.; Mcgowan, S.; Angelini, L.; O'Kelly, R.; Biashad, S. A.; Hillpot, E.; Morandini, F.; Seluanov, A.; Gorbunova, V.; Dong, X.; Niedernhofer, L. J.; Robbins, P. D.

10.1101/2025.04.27.650852 — cell biology — Posted on 2025-04-28

854 Disruption of Plasma Membrane Lipid Asymmetry Alters Cellular Energetics

Nadler, A.; Barahtjan, P.; Cook, K. C.; Bocan, V.; Lennartz, H. M.; Jumel, T.; Schuhmann, K.; Traikov, S.; Bölig, K.; Kuhn, S. M.; Jimenez-Lopez, C.; Alves, T. C.; Shevchenko, A.; Rodenfels, J.

10.1101/2025.04.27.650841 — cell biology — Posted on 2025-04-28

855 The ferroptosis inhibitor NUPR1 coordinates the mitochondrial response to oxidative stress and cell metabolism during COPD pathogenesis in the lung

Siller, S. S.; Yang, T.; Nouws, J.; Kim, S.-J.; Kim, S.-H.; Santofimia-Castano, P.; Iovanna, J.; McDonough, J. E.; Sauler, M.

10.1101/2025.04.27.650854 — cell biology — Posted on 2025-04-28

856 N-Acetyl-l-Leucine (NALL) rescues inter-organelle communication in Niemann-Pick disease type-C patient cells.

Kiraly, S.; Martello, A.; Platt, F. M.; Eden, E. R.

10.1101/2025.04.27.650877 — cell biology — Posted on 2025-04-28

857 The Infraslow Fluctuation of Sigma Power During Sleep in Young Individuals with Schizophrenia

Dimitriades, M. E.; Schumacher, E.; Arudchelvam, J.; Fattinger, S.; Kurth, S.; Pugin, F.; Wehrle, F.; Jaramillo, V.; Volk, C.; Leach, S.; Buckley, A.; Driver, D.; Markovic, A.; Rapoport, J. L.; Tarokh, L.; Huber, R.; Gerstenberg, M.

10.1101/2025.04.23.650209 — neuroscience — Posted on 2025-04-26

858 Neuronal processes contain the essential components for the late steps of ribosome biogenesis

Fusco, C. M.; Staab, A.; Bourke, A. M.; Tushev, G.; Desch, K.; Moreto Lins, E.; Ciirdaeva, E.; tom Dieck, S.; Kaltenschnee, N.; Heckel, A.; Langer, J. D.; Schuman, E. M.

10.1101/2025.04.28.650935 — cell biology — Posted on 2025-04-28

859 Shape-Shifting Conotoxins Reveal Divergent Pore-Targeting Mechanisms in Nicotinic Receptors

Bhattacharjee, B.; Noviello, C. M.; Rahman, M. M.; Mayer, J. P.; Gajewiak, J.; McIntosh, J. M.; Hibbs, R. E.; Stowell, m. H. B.

10.1101/2025.04.23.650119 — neuroscience — Posted on 2025-04-26

860 Increased in vivo transduction of AAV-9 cargo in Alport podocytes

Williams, E.; Fresquet, M.; Bolas, G.; Kaseda, S.; Goncalves, K.; Steinsapir, A.; Adamson, A. D.; Sherwood, D. R.; Lennon, R.

10.1101/2025.04.28.650965 — cell biology — Posted on 2025-04-28

861 Structural dynamics of mixed-subunit CaMKIIα/β heterododecamers filmed by high-speed AFM

Matsushima, K.; Sumikama, T.; Suzuki, T.; Ito, M.; Nagasawa, Y.; Sumino, A.; Flechsig, H.; Ogoshi, T.; Umeda, K.; Kodera, N.; Murakoshi, H.; Shibata, M.

10.1101/2025.04.24.650392 — neuroscience — Posted on 2025-04-26

862 NAMPT activity plays a key role in driving autoimmune processes that characterize type 1 diabetes development in mice

Egbase, D.; Sayers, S.; Haq, N.; Varghese, J.; Gesheva, V.; Bhattacharya, S.; Kynaston, J.; Hubber, E.; Smith, L.; Pullen, T.; Gerdes, H.; Lee, V.; Hopkins, D.; Zhao, M.; Cheah, Y.; Greally, J.; Butterworth, S.; Pearson, J. A.; Bewick, G. A.; Persaud, S.; Caton, P.

10.1101/2025.01.14.632985 — cell biology — Posted on 2025-04-28

863 Neural microexons modulate arousal states via cAMP signalling in zebrafish

Mackensen, T.; Iniguez, L. P.; Mullen, T. S.; Rodriguez-Marin, C.; Kroll, F.; Zuccarini, G.; Fernandez-Albert, J.; Sancho-Vila, L.; Permanyer, J.; Bianco, I. H.; Orger, M. B.; Rihel, J.; Irimia, M.

10.1101/2025.04.24.650407 — neuroscience — Posted on 2025-04-26

864 Maturation stage-specific V-ATPase disassembly can explain neutral pH of lysosome-related organelles

Pradhan, A.; Tadasare, N.; Sarkar, D.; Maurya, V.; Bansal, L. K.; Turkewitz, A. P.; Kumar, S.

10.1101/2025.01.13.632790 — cell biology — Posted on 2025-04-28

865 Does slow oscillation-spindle coupling contribute to sleep-dependent memory consolidation? A Bayesian meta-analysis

Ng, T.; Noh, E.; Spencer, R. M. C.

10.1101/2024.08.28.610060 — neuroscience — Posted on 2025-04-26

866 SON-dependent nuclear speckle rejuvenation alleviates proteinopathies

Dion, W.; Tao, Y.; Chambers, M.; Zhao, S.; Arbuckle, R. K.; Sun, M.; Kubra, S.; Schaich, M.; Nie, Y.; Ye, M.; Jamal, I.; Larsen, M. B.; Camarco, D.; Ickes, E.; Wang, H.; DuPont, C.; Wang, B.; Liu, S.; Pi, S.; Van Houten, B.; Chen, B. B.; Chen, Y.; Chen, X.; Zhu, B.

10.1101/2024.04.18.590103 — cell biology — Posted on 2025-04-28

867 Complement receptor C3ar1 deficiency does not alter brain structure or functional connectivity across early life development

Lemmik, H.; Kim, E.; MacNicol, E.; Maselli, D.; Bernanos, M.; Li, Z.; Abdullahi, D.; Walters, E.; Serrano Navacerrada, M. E.; Zhou, W.; Ivetic, A.; Cash, D.; Westacott, L.

10.1101/2025.04.24.650541 — neuroscience — Posted on 2025-04-26

868 The DNA damage response in myogenic C2C7 cells depends on the characteristics of ionizing particles

Sutcu, H. H.; Thomas-Joyeux, A.; Cardot-Martin, M.; Dugue, D.; Vianna, F.; Perrot, Y.; Benadjaoud, M. A.; Benderitter, M.; Baldeyron, C.

10.1101/2024.06.24.600399 — cell biology — Posted on 2025-04-28

869 Disruption of Plasma Membrane Lipid Asymmetry Alters Cellular Energetics

Barahtjan, P.; Cook, K. C.; Bocan, V.; Lennartz, H. M.; Jumel, T.; Schuhmann, K.; Traikov, S.; Bölig, K.; Kuhn, S. M.; Jimenez-Lopez, C.; Alves, T. C.; Shevchenko, A.; Rodenfels, J.; Nadler, A.

10.1101/2025.04.27.650841 — cell biology — Posted on 2025-04-28

870 One model to rule them all: unification of voltage-gated potassium channel models via deep non-linear mixed effects modelling

Linkevicius, D.; Chadwick, A.; Stefan, M. I.; Sterratt, D. C.

10.1101/2025.04.24.650426 — neuroscience — Posted on 2025-04-26

871 Quantification of morphological, functional, and biochemical features of H9c2 rat cardiomyoblast retinoic acid differentiation

York, N. S.; Rivera, J. E.; Manesh, M. R.; Lynes-Ford, K. W.; Smith, R.; Wicki-Stordeur, L. E.; Arbour, L. T.; Swayne, L. A.

10.1101/2024.12.10.627787 — cell biology — Posted on 2025-04-29

872 Integrative Gene Co-expression Network Analysis Reveals Protein-Coding and lncRNA Genes Associated with Alzheimer's Disease Pathology

Zebardast, F.; Riethmueller, M. P. S.; Nowick, K.

10.1101/2025.01.19.633755 — neuroscience — Posted on 2025-04-26

873 Isolating the Contribution of the Koniocellular Visual Pathway in Aversive Learning in Human Visual Cortex

McCain, K. J.; Petro, N. M.; Keil, A.

10.1101/2025.04.24.650318 — neuroscience — Posted on 2025-04-26

874 Attentional inhibition by alpha power is modulated by faster theta rhythm and audio-visual congruency during natural speech perception

Byczynski, G. E.; Park, H.

10.1101/2024.02.25.581860 — neuroscience — Posted on 2025-04-26

875 More running causes more ocular dominance plasticity in mouse primary visual cortex: new gated running wheel setup allows to quantify individual running behaviour of group-housed mice

Schoene, C.; Sathiyamani, J. S.; Guranda, M.; Schnurbusch, N.; Loewel, S.

10.1101/2025.04.25.647197 — neuroscience — Posted on 2025-04-26

876 Head-Direction Cells in Postsubiculum Show Systematic Parallax Errors During Visual Anchoring

Krausse, S.; Neftci, E.; Sommer, F. T.; Renner, A.

10.1101/2025.04.25.650191 — neuroscience — Posted on 2025-04-26

877 Reading ahead: Localized neural signatures of parafoveal word processing and skipping decisions

Flick, G.; Pylkkänen, L.

10.1101/2025.04.25.650296 — neuroscience — Posted on 2025-04-27

878 Intrinsic rewards guide visual resource allocation via reinforcement learning

Tomic, I.; Raimundo, R.; Bays, P. M.

10.1101/2025.04.25.650663 — neuroscience — Posted on 2025-04-27

879 Spontaneously emerging patterns in human motor cortex code for somatotopic specific movements

Zhang, L.; Pini, L.; Shulman, G. L.; Corbetta, M.

10.1101/2025.04.26.650747 — neuroscience — Posted on 2025-04-27

880 GABAergic neurons are major contributors of network inhibition in the neonatal hippocampus in-vivo

Mortet, S.; Carayon, R.; Baude, A.; Brustlein, S.; Cossart, R.; Lenck-Santini, P.-P.

10.1101/2025.04.26.650764 — neuroscience — Posted on 2025-04-27

881 Early Emergence of Perceptual Biases in Working Memory

Serrano-Fernandez, L.; Romo, R.; Parga, N.

10.1101/2025.04.26.650749 — neuroscience — Posted on 2025-04-27

882 Identification of a Thermogenic Target in the Dorsal Raphe Nucleus for Weight Management

Moura-Assis, A.; Plucinska, K.; Baleisyte, A.; David, D.; Pellegrino, K.; Parolari, L.; Shaked, P. T.; Page, K. J.; Douglas, D. W.; Carrol, T. S.; Grajales-Reyes, J. G.; Na, D.; Schiffer, H. H.; Chen, Y.; Sun, H.; Cohen, N.; Monenschein, H.; Barker, D. F.; Ortuno, M. J.; Renier, N.; Cohen, P.; Carlton, M.; Heintz, N.; Brice, N. L.; Friedman, J. M.; Schneeberger, M.

10.1101/2025.04.24.650283 — neuroscience — Posted on 2025-04-27

883 Attractive and repulsive history effects in categorical and continuous estimates of orientation perception

Can, M.; Collins, T.

10.1101/2025.04.24.650437 — neuroscience — Posted on 2025-04-27

884 Modelling Fragile X-Associated Neuropsychiatric Disorders in Young Inducible 90CGG Premutation Mice

Caliskan, G.; Lacalle, S. E.; Kul, E.; Angel, M. d.; Zambrano, A. L.; Hukema, R.; Santos, M.; Stork, O.

10.1101/2025.04.24.650447 — neuroscience — Posted on 2025-04-27

885 Inferring macroscopic intrinsic neural timescales using optimal control theory

Kim, J. Z.; Betzel, R. F.; Beyh, A.; Howell, A.; Kuceyeski, A.; Larsen, B.; Seguin, C.; Zhang, X.-H.; Holmes, A.; Parkes, L.

10.1101/2025.04.24.650287 — neuroscience — Posted on 2025-04-27

886 High-level visual cortex representations are organized along visual rather than abstract principles.

Shoham, A.; Broday-Dvir, R.; Malach, R.; Yovel, G.

10.1101/2024.11.12.623145 — neuroscience — Posted on 2025-04-27

887 Eye movement patterns under exposure to spatial disorientation illusions during simulated flight

Harel, M.; Nakdimon, I.; Ben-Ari, O.; Schonberg, T.

10.1101/2025.01.28.635199 — neuroscience — Posted on 2025-04-27

888 Natural scene and object perception based on statistical image features: psychophysics and EEG

Orima, T.; Kurosawa, F.; Sekimoto, T.; Motoyoshi, I.

10.1101/2025.04.23.650126 — neuroscience — Posted on 2025-04-27

889 Combined CSF1R Inhibition and Sensory Gamma Stimulation Provide Protective Effects in a Mouse Model of Alzheimers Disease

Adaikkan, C.; Islam, M. R.; Bozzelli, P. L.; Sears, M.; Parro, C.; Pao, P.-C.; Sun, N.; Kim, T.; Abdelaal, K.; Sedgwick, M.; Kellis, M.; Tsai, L.-H.

10.1101/2025.04.27.648471 — neuroscience — Posted on 2025-04-28

890 Hypothalamic deiodinase type-3 establishes the period of circannual interval timing in mammals

Stewart, C.; Liddle, A.; Tolla, E.; Lewis, J. E.; Marshall, C. J.; Evans, N.; Morgan, P.; Ebling, F.; Stevenson, T.

10.1101/2025.04.22.650143 — neuroscience — Posted on 2025-04-28

891 Temporal variation in the acoustic dynamic range is a confounding factor in EEG-based tracking of absolute auditory attention to speech

Li, T.; Geirnaert, S.; Van den Broek, D.; Bellon, E.; De Smedt, B.; Bertrand, A.

10.1101/2025.03.04.641391 — neuroscience — Posted on 2025-04-28

892 Hippocampal ripples initiate cortical dimensionality expansion for memory retrieval

Kerren, C.; Michelmann, S.; Doeller, C. F.

10.1101/2025.04.22.649929 — neuroscience — Posted on 2025-04-28

893 No Disconnection Syndrome after Near-Complete Callosotomy

Bekir, S.; Hopf, J. L.; Paul, T.; Wiemer, V. M.; Santander, T.; Skinner, H. E.; Rada, A.; Woermann, F. G.; Kalbhenn, T.; Giesbrecht, B.; Bien, C. G.; Sporns, O.; Gazzaniga, M. S.; Volz, L. J.; Miller, M. B.

10.1101/2025.02.16.638524 — neuroscience — Posted on 2025-04-28

894 Lussac: a fully-automated consensus method that increasesthe yield and quality of spike-sorting analyses

Wyngaard, A. J. G.; Llobet, V.; Barbour, B.

10.1101/2022.02.08.479192 — neuroscience — Posted on 2025-04-28

895 Cortical state contributions to response variability in the early visual cortex: A system identification approach

Sooriyaarachchi, J.; Zhan, C.; Baker, C.

10.1101/2024.09.17.613530 — neuroscience — Posted on 2025-04-28

896 Cortical substrates of perceptual confusion between pitch and timbre

Ou, Y.; Allen, E. J.; Kay, K. N.; Oxenham, A. J.

10.1101/2025.02.19.639197 — neuroscience — Posted on 2025-04-28

897 Circuit-specific selective vulnerability in the DMN persists in the face of widespread amyloid burden.

Brunwasser, S. J.; McGregor, J. N.; Farris, C.; Elmore, H.; Dyer, E. L.; Nair, K. B.; Whitesell, J. D.; Harris, J. A.; Hengen, K. B.

10.1101/2022.11.14.516510 — neuroscience — Posted on 2025-04-28

898 Developmental dynamics and axonal transport of cerebral cortex projection neuron mRNAs in vivo

Veeraraghavan, P.; Tillman, D. E.; Ross, M. I.; Macklis, J. D.

10.1101/2025.04.23.650263 — neuroscience — Posted on 2025-04-28

899 Toward Unified Biomarkers for Focal Epilepsy

Wang, S. H.; Ferrari, P.; Arnulfo, G.; Marzulli, M.; Degras, D.; Myrov, V.; Palva, S.; Nobili, L.; Ciuciu, P.; Palva, M.

10.1101/2025.04.15.647522 — neuroscience — Posted on 2025-04-28

900 Region-specific modulation and predictive potential of the oscillatory dynamics in an ex vivo model of ictogenesis in the CA1, CA3 and dentate gyrus

Vagiaki, L.-E.; Xydias, D.; Kefalogianni, M.; Psilodimitrakopoulos, S.; Stratakis, E.; Sidiropoulou, K.

10.1101/2024.08.23.609340 — neuroscience — Posted on 2025-04-28

901 Neuroinflammation driven by TLR7 activation in mice results in a global inflammatory response driving circuit-specific changes in neuronal gene expression

Gardner-Steven, K.; Carvajal-Quisilema, R.; Andrianova, L.; McGonigal, R.; Sharma, D.; Barrie, J.; Saathoff, M.; Cole, J. J.; Jamieson, N. B.; Craig, M. T.; Cavanagh, J. T.

10.1101/2025.04.25.650583 — neuroscience — Posted on 2025-04-28

902 An updated catalogue of split-GAL4 driver lines for descending neurons in Drosophila melanogaster

Zung, J. L.; Namiki, S.; Meissner, G. W.; Cheong, H. S. J.; Costa, M.; Eichler, K.; Stürner, T.; Jefferis, G. S. X. E.; Managan, C.; FlyLight Project Team, ; Korff, W.; Card, G. M.

10.1101/2025.02.22.639679 — neuroscience — Posted on 2025-04-28

903 Dynamic estimation of the attentional field from visual cortical activity

Bloem, I. M.; Bakst, L.; McGuire, J. T.; Ling, S.

10.1101/2024.09.05.611383 — neuroscience — Posted on 2025-04-28

904 Are online corrections to visual targets really a distinct class of movement?

Mekhaiel, D. Y.; Goodale, M. A.; Corneil, B. D.

10.1101/2025.03.14.643316 — neuroscience — Posted on 2025-04-28

905 Central infusion of prostaglandin E2 reveals a unified representation of sickness in the mouse insular cortex

Kamm, G. B.; Boffi, J. C.; Abd El Hay, M.; Rajot, D.; Cukic, A.; Havenith, M.; Scholvinck, M.; Renier, N.; Asari, H.; Prevedel, R.

10.1101/2025.04.28.651028 — neuroscience — Posted on 2025-04-28

906 Key genes and pathways in asparagine metabolism in Alzheimers Disease: a bioinformatics approach

Zhong, L.; Lan, X.; Feng, G.; Li, Q.; Shi, Y.; Qin, S.

10.1101/2025.04.25.650586 — neuroscience — Posted on 2025-04-28

907 Preclinical assay of the effects of lacosamide, pregabalin and tapentadol on the rat N1 spinal somatosensory evoked potential.

Steel, K. A. J.; Dunham, J. P.; Leone, C.; Truini, A.; Treede, R.-D.; Phillips, K. G.; Krajewski, J.; Blockeel, A.; Pickering, A. E.

10.1101/2025.04.25.650582 — neuroscience — Posted on 2025-04-28

908 The Interplay of Bottom-Up Arousal and Attentional Capture during Auditory Scene Analysis: Evidence from Ocular Dynamics

Huviyetli, M.; Chait, M.

10.1101/2025.04.25.650619 — neuroscience — Posted on 2025-04-28

909 The Interplay of Bottom-Up Arousal and Attentional Capture during Auditory Scene Analysis: Evidence from Ocular Dynamics

Huviyetli, M.; Chait, M.

10.1101/2025.04.25.650619 — neuroscience — Posted on 2025-04-28

910 Imaging traumatic brain injuries in mice with potassium channel PET tracer 3F4AP

Ramos-Torres, K. M.; Takahashi, K.; Radomski, K. L.; Mandeville, E. T.; Zhang, L.; Zhou, Y.-P.; Lo, E. H.; Armstrong, R. C.; Brugarolas, P.

10.1101/2025.04.23.650093 — neuroscience — Posted on 2025-04-28

911 Imaging traumatic brain injuries in mice with potassium channel PET tracer 3F4AP

Ramos-Torres, K. M.; Takahashi, K.; Radomski, K. L.; Mandeville, E. T.; Zhang, L.; Zhou, Y.-P.; Lo, E. H.; Armstrong, R. C.; Brugarolas, P.

10.1101/2025.04.23.650093 — neuroscience — Posted on 2025-04-28

912 Spatiotemporal biases in localization and interception: common underlying mechanisms?

Schroeger, A.; Merz, S.

10.1101/2025.04.25.650604 — neuroscience — Posted on 2025-04-28

913 Spatiotemporal biases in localization and interception: common underlying mechanisms?

Schroeger, A.; Merz, S.

10.1101/2025.04.25.650604 — neuroscience — Posted on 2025-04-28

914 Ayahuasca Shifts Brain Dynamics Toward Higher Entropy: Persistent Elevation of Ising Temperature Correlates with Acute Subjective Effects

Cabral-Carvalho, R. d. M.; Palhano-Fontes, F.; de Araujo, D. B.; Sato, J. R.

10.1101/2025.04.25.650509 — neuroscience — Posted on 2025-04-28

915 Spatially resolved transcriptomics reveals a unique disease signature and potential biomarkers for chronic traumatic encephalopathy

Suter, C. M.; Cropley, J. E.; Affleck, A.; Lee, M.; Hammond, K.; Gloss, B.; Buckland, M. E.

10.1101/2025.04.23.650359 — neuroscience — Posted on 2025-04-28

916 Optimizing electrode placement and information capacity for local field potentials in cortex

Willis, J. A.; Wright, C. E.; Zhu, R.; Ruan, Y.; Stallings, J.; Abrego, A. M.; Joshi, A. A.; Leahy, R. M.; Tandon, N.; Seymour, J. P.

10.1101/2025.04.25.650658 — neuroscience — Posted on 2025-04-28

917 Vasoactive Neuropeptide Dysregulation: A Novel Mechanism of Microvascular Dysfunction in Vascular Cognitive Impairment

Tambo, W.; Powell, K.; Wadolowski, S.; Unadkhat, P.; Chang, E. H.-Y.; Ledoux, C.; Sciubba, D.; Wang, P.; Huerta, P.; Li, C.

10.1101/2025.04.25.650644 — neuroscience — Posted on 2025-04-28

918 Metabolic Origins of Neurotoxic 1-deoxySphingolipids in Type 2 Diabetes

Majcher, A.; Bjorklund, P.; Holfeld, A.; Cinakova, A.; Zurcher, A.; Malagola, E.; Yusifov, E.; Kakava, S.; Robert, J.; Hardfeldt, J.; Hadova, K.; Kralova, E.; Levkau, B.; Othman, A.; Belgard, B.; Lauria, G.; Angelin, B.; Hornemann, T.

10.1101/2025.04.25.650588 — neuroscience — Posted on 2025-04-28

919 Mapping the functional differentiation and interactions among the inferior, medial frontal and posterior temporal cortex in semantic control

Liu, J.; Wang, X.; Zhang, H.; Yang, J.; Gao, X.; Li, Z.; Wang, Y.; Hu, Z.; Li, J.; Li, W.; Huang, Y.; Chen, J.; Zeng, L.; Weng, X.; Yuan, B.

10.1101/2025.04.28.650132 — neuroscience — Posted on 2025-04-28

920 Multi-modal screening for synergistic neuroprotection of extremely preterm brain injury

Jin, Z. R.; Corry, K. A.; Brandon, O. C.; Magoon, M. J.; Helmbrecht, H.; Moralejo, D. H.; Bassett, R.; Kolnik, S. E.; Boyle, P. M.; Juul, S. E.; Nance, E.; Wood, T. R.

10.1101/2025.04.25.650638 — neuroscience — Posted on 2025-04-29

921 Association between high-frequency hearing sensitivity and visual cross-modal plasticity in typical-hearing adults

Paul, B. T.; Srikanthanathan, A.; Chen, J.; Le, T.; Lin, V.; Dimitrijevic, A.

10.1101/2025.04.28.648945 — neuroscience — Posted on 2025-04-29

922 Multivariate white matter microstructure alterations in older adults with coronary artery disease

Tremblay, S. A.; Potvin-Jutras, Z.; Sabra, D.; Rezaei, A.; Sanami, S.; Gagnon, C.; Intzandt, B.; Mainville-Berthiaume, A.; Wright, L.; Leppert, I. R.; Tardif, C. L.; Steele, C. J.; Iglesies-Grau, J.; Nigam, A.; Bherer, L.; Gauthier, C. J.

10.1101/2025.04.25.650626 — neuroscience — Posted on 2025-04-29

923 PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation

Wang, S.; Baumert, R.; Sejourne, G.; Sivadasan Bindu, D.; Dimond, K.; Sakers, K.; Vazquez, L.; Moore, J. L.; Tan, C. X.; Takano, T.; Rodriguez, M. P.; Brose, N.; Bradley, L.; Lessing, R.; Soderling, S. H.; La Spada, A. R.; Eroglu, C.

10.1101/2023.04.09.536178 — neuroscience — Posted on 2025-04-29

924 β-adrenergic receptor activation modulates the induction of complex spike burst-dependent LTP by regulating multiple forms of heterosynaptic plasticity

O'Dell, T. J.

10.1101/2025.04.28.651102 — neuroscience — Posted on 2025-04-29

925 Persistent Light-Induced Reduction of Neuronal Excitability: Implications for Non-Optogenetic control of Brain Actvity

Lightning, A.; Di Rocco, F.; Guenot, M.; Kuczewski, N.

10.1101/2025.04.25.650615 — neuroscience — Posted on 2025-04-29

926 Sharpened visual memory representations are reflected in inferotemporal cortex

Jannuzi, B. G. L.; Hacker, C. M.; Bohn, S.; Meyer, T.; Hay, M. L.; Rust, N. C.

10.1101/2025.04.28.651105 — neuroscience — Posted on 2025-04-29

927 Resting State Functional Connectivity of the Marmoset Claustrum

Holzscherer, E.; Zanini, A.; Liu, C. Y.; Everling, S.; Seminowicz, D. A.

10.1101/2025.04.25.650655 — neuroscience — Posted on 2025-04-29

928 Cellular and molecular underpinnings of functional networks in the human brain

Feng, G.; Chen, J.; Sui, J.; Calhoun, V. D.

10.1101/2025.04.28.651051 — neuroscience — Posted on 2025-04-29

929 Maternal Immune Activation Disrupts Epigenomic and Functional Maturation of Cortical Excitatory Neurons

Lai, C.-Y.; Arzavala, J.; Duarte, A. P.; Wang, S.; Li, J.; Liu, H.; Osteen, J.; Castanon, R. G.; Nery, J. R.; Powell, S. B.; Ecker, J. R.; Mukamel, E. A.; Behrens, M. M.

10.1101/2025.04.28.651094 — neuroscience — Posted on 2025-04-29

930 Dysregulation of Multiple Solute Carrier genes and Metabolic Deficits in SLC1A4-Mutant Human iPSC-Derived Hippocampal Neurons

Nayak, R.; sharma, O.; Mizrahi, L.; Shemen, A.; Tripathi, U.; Hussein, Y.; Rike, W. A.; Rosh, I.; Radzishevsky, I.; Mandel, H.; Ladewig, J.; Zaccai, T. F.; Wolosker, H.; Stern, S.

10.1101/2025.04.25.650669 — neuroscience — Posted on 2025-04-29

931 Miniaturized and accessible functional ultrasound imaging system for freely moving mice

Yang, J.; Zhou, E.; Zhu, J.; Zhu, T.; Zhao, J.; Lin, X.; Cao, Z.; Chen, Z.; An, Z.; Sun, L.; Wu, W.; Qiu, Z.

10.1101/2025.04.24.650351 — neuroscience — Posted on 2025-04-29

932 Logarithmic coding leads to adaptive stabilization in the presence of sensorimotor delays

Demarchi, L.; Coraggioso, M.; Hubert, A.; Panier, T.; Morvan-Dubois, G.; Bormuth, V.; Debregeas, G.

10.1101/2025.04.28.650940 — neuroscience — Posted on 2025-04-29

933 GABAergic network from AVP neurons to VIP neurons in the suprachiasmatic nucleus sets the activity/rest time of the circadian behavior rhythm

Peng, Y.; Tsuno, Y.; Maejima, T.; Wang, M.; Matsui, A.; Mieda, M.

10.1101/2025.04.28.650944 — neuroscience — Posted on 2025-04-29

934 Alcohol Attenuates CRF-Induced Excitatory Effects from the Extended Amygdala to Dorsostriatal Cholinergic Interneurons

Essoh, A.; Gangal, H.; Huang, Z.; Chen, R.; Xie, X.; Wang, X.; Vierkant, V.; Garza, M.; Ugartemendia, L.; Secci, M. E.; Gilpin, N. W.; Justice, N. J.; Messing, R. O.; Wang, J.

10.1101/2025.04.23.650346 — neuroscience — Posted on 2025-04-29

935 Specialized parallel pathways for adaptive control of visual object pursuit

Collie, M. F.; Jin, C.; Kellogg, E.; Vanderbeck, Q. X.; Hartman, A. K.; Holtz, S. L.; Wilson, R. I.

10.1101/2025.04.23.650240 — neuroscience — Posted on 2025-04-29

936 Fetal magnetoencephalography based on optically pumped magnetometers

Corvilain, P.; Capparini, C.; Wens, V.; Fourdin, L.; Ferez, M.; Feys, O.; Delbaere, A.; Lejeune, R.; Goldman, D.; De Coninck, C.; De Tiege, X.; Bertels, J.

10.1101/2025.04.23.650121 — neuroscience — Posted on 2025-04-29

937 Alpha-synuclein phosphorylation is abundant in the non-synucleinopathy human brain

Choi, S.; Duvernay, J.; Bahrami, A.; Tittle, T.; Sani, S.; Kordower, J.; Muller, S.; Killinger, B.

10.1101/2025.04.22.649861 — neuroscience — Posted on 2025-04-29

938 Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels.

Weir, K.; Lyu, P.; Kandoi, S.; An, R.; Pannullo, N.; Palaxxo, I.; Tangeman, J.; Shi, J.; DeVries, S.; Merriman, D.; Qian, J.; Blackshaw, S.

10.1101/2025.04.25.650540 — neuroscience — Posted on 2025-04-29

939 Dynamic neural representations of scene beauty are relatively unaffected by stimulus timing and task

Nara, S.; Becker, L.; Hillebrand, L.; Xiang, R.; Kaiser, D.

10.1101/2025.04.22.649954 — neuroscience — Posted on 2025-04-29

940 Uncovering the Neural Fingerprint of Akinetic States in a Parkinsons Disease Rodent Model

Garulli, E. L.; Merk, T.; El Hasbani, G.; Kabaoglu, B.; De Sa, R.; Behrsing, R.; Doll, D.; Schellenberger, M.; Vogt, A.; Neumann, W.-J.; Peng, Y.; Endres, M.; Harms, C.; Wenger, N.

10.1101/2025.04.22.650006 — neuroscience — Posted on 2025-04-29

941 Comparison of Neural Tracking and Spectral Entropy in Patients with Disorders of Consciousness

Sonck, R.; Laureys, S.; Diels, P.; Francart, T.; Vanthornhout, J.

10.1101/2025.04.21.649509 — neuroscience — Posted on 2025-04-29

942 Repeated Binge-Like Alcohol Drinking Heightens Aggression in Mice

Frier, M. D.; Biggi, N. P.; Babb, J. A.; Newman, E. L.; Covington, H. E.; Weera, M. M.

10.1101/2025.04.22.650080 — neuroscience — Posted on 2025-04-29

943 Multi-cohort, multi-sequence harmonisation for cerebrovascular brain age

Dijsselhof, M. B. J.; Moore, C.; Amiri, S.; Tee, M.; Hilal, S.; Chen, C.; van den Born, B.-J. H.; Nordhoy, W.; Andreassen, O. A.; Westlye, L. T.; Chaturvedi, N.; Hughes, A. D.; Cash, D. M.; Schott, J. M.; Sudre, C. H.; Barkhof, F.; Kuijer, J. P. A.; Biondo, F.; Cole, J. H.; Mutsaerts, H. J. M. M.; Petr, J.

10.1101/2025.04.22.649344 — neuroscience — Posted on 2025-04-29

944 Base exchange inhibitors of SARM1 form mononucleotide adducts and activate SARM1 in vivo

Reardon, H. T.; Guijas, C.; Clapper, J. R.; Callender, J. A.; Kozina, E. M.; Sarabia, F. J.; Hutton, C.; Herbst, D. M.; Andalis, T.; Perehinets, L.; Henry, C. L.; Lebold, T. P.; Kummer, D. A.; Blankman, J. L.; Wiener, J. J. M.; Simonsen, K. B.; Samad, T. A.

10.1101/2025.04.22.649875 — neuroscience — Posted on 2025-04-29

945 The ciliary kinesin KIF7 controls the development of the cerebral cortex by acting differentially on SHH-signaling in dorsal and ventral forebrain

PEDRAZA, M.; GRAMPA, V.; SCOTTO-LOMASSESE, S.; PUECH, J.; MUZERELLE, A.; MOHAMMAD, A.; Lebon, S.; RENIER, N.; METIN, C.; MASSON, J.

10.1101/2024.03.21.586159 — neuroscience — Posted on 2025-04-29

946 Immediately following the onset of active whisking, the input layer of barrel cortex exhibits a transient period of increased excitability that depends on prior experience

Shallow, M. C.; Tian, L.; Higashikubo, B. T.; Lin, H.; Lefton, K. B.; Chen, S.; Dougherty, J. D.; Culver, J. P.; Lambo, M. E.; Hengen, K. B.

10.1101/2024.06.04.597353 — neuroscience — Posted on 2025-04-29

947 UBE3C links ubiquitin signaling to epitranscriptomic control of cortical neurogenesis

Borisova, E.; Cuthill, K. J.; Dannenberg, R.; Koch, J.; Nowaczyk, J.; Schaub, T.; Schwark, M.; Kastelic, N.; Kupryianchyk-Schultz, I.; Kirchner, M.; Pentimalli, T. M.; Fokkens, T. J.; Stein, F.; Dietrich, C.; Quedenau, C.; Borodina, T.; Schwefel, D.; Conrad, T.; Rybak-Wolf, A.; Rajewsky, N.; Mertins, P.; Haberkant, P.; Lorenz, S.; Brose, N.; Kawabe, H.; Tarabykin, V.; Ambrozkiewicz, M. C.

10.1101/2025.04.09.646620 — neuroscience — Posted on 2025-04-29

948 Anaesthesia disrupts mesoscale signal propagation in spite of enhanced responsivity in frontal but not in parietal cortex

Dwarakanath, A.; Khalili-Ardali, M.; Gay, M.; HV, R.; Roustan, M.; Dehaene, S.; Jarraya, B.; Panagiotaropoulos, T.

10.1101/2025.04.15.648923 — neuroscience — Posted on 2025-04-29

949 Disentangling Arousal and Attentional Contributions to Pupil Size: Toward Simultaneous Estimation of Emotional and Cognitive States

Tsutsumi, T.; Kanari, K.

10.1101/2025.04.22.649972 — neuroscience — Posted on 2025-04-29

950 Familial Alzheimer disease mutation identifies novel role of SORLA in release of neurotrophic exosomes

Juul-Madsen, K.; Rudolph, I.-M.; Gomes, J. P.; Meyer, K.; Ovesen, P. L.; Gorniak-Walas, M. J.; Kokoli, M.; Telugu, N. S.; Sivertsen, M. v. T.; Sutherland, D. S.; Palmfeldt, J.; Diecke, S.; Andersen, O. M.; Selbach, M.; Willnow, T. E.

10.1101/2025.04.22.649924 — neuroscience — Posted on 2025-04-29

951 Hippocampal ripples initiate cortical dimensionality expansion for memory retrieval

Kerren, C.; Michelmann, S.; Doeller, C. F.

10.1101/2025.04.22.649929 — neuroscience — Posted on 2025-04-29

952 Natural scene and object perception based on statistical image feature: psychophysics and EEG

Orima, T.; Kurosawa, F.; Sekimoto, T.; Motoyoshi, I.

10.1101/2025.04.23.650126 — neuroscience — Posted on 2025-04-29

953 Towards individualized deep brain stimulation: A stereoencephalography-based workflow for unbiased neurostimulation target identification

Saal, J.; Kadlec, K.; Allawala, A. B.; Johnston, L.; Leriche, R.; Vatsyayan, R.; Han, Y.; Kist, A.; Di Ianni, T.; Dawes, H. E.; Chang, E. F.; Lee, A. M.; Krystal, A. D.; Moussawi, K.; Shirvalkar, P.; Sellers, K. K.

10.1101/2025.04.22.649607 — neuroscience — Posted on 2025-04-29

954 Cell-type specific projection patterns promote balanced activity in cortical microcircuits

Kurth, A. C.; Albers, J.; Diesmann, M.; van Albada, S. J.

10.1101/2024.10.03.616539 — neuroscience — Posted on 2025-04-29

955 Fast 3D imaging in the auditory cortex of awake mice reveals that astrocytes control neurovascular coupling responses at arteriole-capillary junctions.

Lind, B. L.; Volterra, A.

10.1101/2024.06.28.601145 — neuroscience — Posted on 2025-04-27

956 Neuralace: Manufacture, Parylene-C Coating, and Mechanical Properties

Botero Torres, J. P.; Roberts, S. M.; Mackowiak, P.; Witham, N.; Selzer, L.; Srikanthan, B.; Negi, S.; Zoschke, K.; Solzbacher, F.

10.1101/2025.04.24.650335 — neuroscience — Posted on 2025-04-27

957 Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release

Emperador-Melero, J.; Del Signore, S. J.; De Leon Gonzalez, K. M.; Kaeser, P. S.; Rodal, A. A.

10.1101/2025.04.23.650151 — neuroscience — Posted on 2025-04-27

958 The impact of nerve injury on the immune system across the lifespan is sexually dimorphic

Zhou, W. S.; Shi, X. Q.; Zhang, A. P.; Millecamps, M.; Mogil, J.; Zhang, J.

10.1101/2025.04.24.650472 — neuroscience — Posted on 2025-04-27

959 Consolidation of sequential experience into a deep generative network explains human memory, prediction and planning

Spens, E.; Burgess, N.

10.1101/2024.11.04.621950 — neuroscience — Posted on 2025-04-27

960 Hippocampal ripples initiate cortical dimensionality expansion for memory retrieval

Kerren, C.; Doeller, C. F.; Michelmann, S.

10.1101/2025.04.22.649929 — neuroscience — Posted on 2025-04-27

961 Structure-Function Mapping of Olfactory Bulb Circuits with Synchrotron X-ray Nanotomography

Zhang, Y.; Bosch, C.; Ackels, T.; Laugros, A.; Bonnin, A.; Livingstone, J.; Waltenberg, C.; Berning, M.; Tootoonian, S.; Kollo, M.; Nathansen, A.; Rzepka, N.; Cloetens, P.; Pacureanu, A.; Schaefer, A.

10.1101/2025.04.24.650439 — neuroscience — Posted on 2025-04-27

962 Slow Mechanical Filtering by Outer Hair Cells Enhances Rather than Limits Receptor Potential Kinetics

Sahlin Pettersen, H.; Fridberger, A.; Hakizimana, P.

10.1101/2025.04.24.650391 — neuroscience — Posted on 2025-04-27

963 Atypical cortical feedback underlies failure to process contextual information in the superior colliculus of Scn2a+/- autism model mice

Ferrarese, L.; Asari, H.

10.1101/2023.10.31.564905 — neuroscience — Posted on 2025-04-27

964 Anaesthesia disrupts mesoscale signal propagation in spite of enhanced responsivity in frontal but not in parietal cortex

Dwarakanath, A.; Khalili-Ardali, M.; Gay, M.; HV, R.; Roustan, M.; Dehaene, S.; Jarraya, B.; Panagiotaropoulos, T.

10.1101/2025.04.15.648923 — neuroscience — Posted on 2025-04-27

965 Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer's disease

Xiao, Y.; Spotorno, N.; An, L.; Bazinet, V.; Hansen, J. Y.; Strandberg, O.; Shafiei, G.; Behjat, H. H.; Funck, T.; Salvado, G.; Stomrud, E.; Smith, R.; Palmqvist, S.; Ossenkoppele, R.; Mattsson-Carlgren, N.; Palomero-Gallagher, N.; Dagher, A.; Misic, B.; Hansson, O.; Vogel, J. W.

10.1101/2025.04.17.648358 — neuroscience — Posted on 2025-04-27

966 Parametric modulation of a shared midbrain circuit drives distinct vocal modes in a singing mouse

Zheng, X. M.; Harpole, C. E.; Davis, M. B.; Banerjee, A.

10.1101/2025.04.04.647309 — neuroscience — Posted on 2025-04-27

967 Patient-derived Brain Organoids Reveal Divergent Neuronal Activity Across Subpopulations of Autism Spectrum Disorder

Perets, N.; Kerem, L.; Waiskopf, N.; Horesh, N.; Goldman, I.; Avichzer, J.; Tobelaim, W.; Barashi, M.; David, L.; Tenenbaum, A.

10.1101/2025.04.27.650821 — neuroscience — Posted on 2025-04-27

968 Cortical interneurons require JNK signaling for migration regardlessof substrate and topographical environment

Smith, S.

10.1101/2025.04.22.650074 — neuroscience — Posted on 2025-04-28

969 Hippocampal ripples initiate cortical dimensionality expansion for memory retrieval

Kerren, C.; Michelmann, S.; Doeller, C. F.

10.1101/2025.04.22.649929 — neuroscience — Posted on 2025-04-28

970 Neural Alpha Oscillations and Auditory Temporal Coding Reveal Dual Mechanisms of Adaptation to a Cochlear Implant

Woestmann, M.; Meineke, H. M.; Schoenweiler, R.; Hollfelder, D.; Bruchhage, K.-L.; Leichtle, A.; Obleser, J.

10.1101/2025.02.17.638598 — neuroscience — Posted on 2025-04-28

971 The representational geometry of out-of-distribution generalization in primary visual cortex and artificial neural networks

Ye, Z.; Wessel, R.

10.1101/2025.04.23.650305 — neuroscience — Posted on 2025-04-28

972 Tanycyte Bmal1 sex-specifically regulates weight gain and hypothalamic neurogenesis in female mice

Iascone, D. M.; Pivarshev, P.; Yang, J.; Lopez Valencia, M.; Noya, S. B.; Lin, H.; Anafi, R. C.; Bedont, J. L.; Sehgal, A.

10.1101/2025.04.21.649851 — neuroscience — Posted on 2025-04-28

973 Dorso-ventral hippocampus neural assemblies reactivate during sleep following an aversive experience

Morici, J.; Paiva-Lima, I.; Silva, A.; Pronier, E.; Girardeau, G.

10.1101/2024.06.13.598918 — neuroscience — Posted on 2025-04-28

974 Differential changes in the effective neural drive following new motor skill acquisition between vastus lateralis and medialis

Cosentino, C.; Cabral, H. V.; A. dos Santos, M.; Pourreza, E.; Inglis, J. G.; Negro, F.

10.1101/2025.04.23.650243 — neuroscience — Posted on 2025-04-28

975 Molecular signature and functional properties of human pluripotent stem cell-derived brain pericytes

Rust, R.; Sagare, A. P.; Kisler, K.; Kim, Y.; Zhang, M.; Griffin, C.; Wang, Y.; Clementel, V.; Torres-Sepulveda, C.; TCW, J.; Zlokovic, B.; Coba, M.

10.1101/2023.06.26.546577 — neuroscience — Posted on 2025-04-28

976 Pathogenic O-GlcNAc dyshomeostasis associated with cortical malformations and hyperactivity

Authier, F.; Jan, A.; Faress, I.; Skoven, C. S.; Esperon-Abril, I.; Tharmakulasingam Balasubramaniam, S.; Coquelin, K.-S.; Nyengaard, J. R.; Scavenius, C.; Attianese, B.; Sevillano-Quispe, O. G.; Eskildesen, S. F.; Thomsen, J. S.; Hansen, B.; van Aalten, D. M.

10.1101/2025.04.27.650822 — neuroscience — Posted on 2025-04-28

977 Amitraz Toxicity in Resistant Varroa Mites Can Be Increased by Inhibiting ABCB1 Transporters

Fine, J. D.; Truong, T. T.; Lucadello, M. C.; Litsey, E. M.; Lamas, Z.; Rinkevich, F.; Nicklisch, S. C.

10.1101/2025.04.23.650251 — pharmacology and toxicology — Posted on 2025-04-26

978 Overcoming acquired doxorubicin resistance of ovarian carcinoma cells by verapamil-mediated promotion of DNA damage-driven cell death

Mukinovic, E.; Federmann, S.; Messling, L.; Sekeres, M.; Mann, J.; Abbey, L.; Kassack, M. U.; Fritz, G.

10.1101/2025.04.23.650268 — pharmacology and toxicology — Posted on 2025-04-26

979 Targeted chelation therapy decreases NLRP3 expression by vascular cells and acts as senomorphic in Chronic Kidney Disorder induced Vascular Calcification.

Arora, S.; Halsey, G.; Tuj-Zohora, F.; Swiss, A.; Vyavahare, N.

10.1101/2025.04.23.650230 — pharmacology and toxicology — Posted on 2025-04-26

980 Biomass-derived Lignin Nanoparticles for the Sustained Delivery of Vascular Endothelial Growth Factor-C

Mavali Zadeh, A.; Gatto, E.; Lettieri, R.; Bokharaie, H.; Caravella, A.; D'Ottavi, C.; di Bartolomeo, E.; Domenici, F.; Sima, S.; Correia, A.; Rauniyar, K.; Klose, A.; Gounani, Z.; Laaksonen, T.; Künnapuu, J.; Jeltsch, M.

10.1101/2025.04.23.649697 — pharmacology and toxicology — Posted on 2025-04-26

981 An Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity

10.1101/2025.04.24.650479 — pharmacology and toxicology — Posted on 2025-04-27

982 Enantioselective Protein Affinity Selection Mass Spectrometry (E-ASMS)

Wang, X.; Sun, J.; Ahmad, S.; Yang, D.; Li, F.; Chan, U. H.; Zeng, H.; Simoben, C. V.; Green, S. R.; Silva, M.; Houliston, S.; Dong, A.; Bolotokova, A.; Gibson, E.; Kutera, M.; Ghiabi, P.; Kondratov, I.; Matviyuk, T.; Chuprina, A.; Mavridi, D.; Lenz, C.; Joerger, A. C.; Brown, B. D.; Heath, R. B.; Yue, W. W.; Robbie, L. K.; Beyett, T. S.; Müller, S.; Knapp, S.; Harding, R.; Schapira, M.; Brown, P. J.; Santhakumar, V.; Ackloo, S.; Arrowsmith, C. H.; Edwards, A. M.; Peng, H.; Halabelian, L.

10.1101/2025.01.17.633682 — pharmacology and toxicology — Posted on 2025-04-28

983 Forecasting Seizure Duration from Neural Connectivity Patterns in a Neural Mass Model

Zarei Eskikand, P.; Cook, M.; Burkitt, A. N.; Grayden, D. B.

10.1101/2025.04.23.650361 — pathology — Posted on 2025-04-26

984 Quantitative 3D imaging of mouse and human intrahepatic bile ducts in homeostasis and liver injury

Hrncir, H. R.; Goodloe, B.; Bombin, S.; Zhang, Z.; Madabhushi, A.; Gracz, A. D.

10.1101/2025.04.21.649839 — pathology — Posted on 2025-04-28

985 The small Canidae from Cuvieri Cave (Quaternary, Pleistocene), Lagoa Santa, eastern Brazil

Chahud, A.

10.1101/2025.04.22.650051 — paleontology — Posted on 2025-04-26

986 Ancient DNA in Lycoptera Fossils: Key Discoveries for Evolution and Methodological Reassessment

Zhao, W.; Guo, Z.; Tian, Z.; Su, T.; Cao, G.; Qi, Z.; Qin, T.; Zhou, W.; Yang, J.; Chen, M.; Zhang, X.; Zhou, C.; Zhu, C.; Tang, M.; Tang, M.; Wu, D.; Song, M.; Guo, Y.; Qiu, L.; Liang, F.; Li, M.-J.; Geng, J.-H.; Zhao, L.-J.; Zhang, S.-J.

10.1101/2023.06.18.545504 — paleontology — Posted on 2025-04-27

987 Unveiling the Mystery of the Petroleum Genome Archive: Paleofauna Activities, Geological History, and aDNA Identification Methods in Nanyang Oilfield

Zhao, W.-Q.; Guo, Z.-Y.; Guo, Y.-Q.; Li, M.-J.; Cao, G.-Q.; Tian, Z.-Y.; Chai, R.; Qiu, L.-Y.; Zeng, J.-H.; Zhang, X.-G.; Qin, T.-C.; Yang, J.-Y.; Chen, M.-J.; Song, M.-R.; Liang, F.; Geng, J.-H.; Zhou, C.-Y.; Zhang, S.-J.; Zhao, L.-J.

10.1101/2024.12.24.630223 — paleontology — Posted on 2025-04-28

988 Evolution of stable reciprocity

Roberts, G.

10.1101/2024.12.17.628959 — evolutionary biology — Posted on 2025-04-25

989 Remote-control meiotic drive of sex chromosomes

Greenberg, N. L.; Patten, M. M.; Schenkel, M. A.

10.1101/2024.11.18.624228 — evolutionary biology — Posted on 2025-04-25

990 Empirical validation of the nearly neutral theory at divergence and population genomic scale across 150 placental mammal genomes

Bastian, M.; Enard, D.; lartillot, n.

10.1101/2025.04.17.649326 — evolutionary biology — Posted on 2025-04-25

991 Transgenerational effects impact the vulnerability of a host-parasitoid system to rising temperatures.

Bright, N. L.; Chen, J.; Terry, C.

10.1101/2024.08.16.608228 — ecology — Posted on 2025-04-25

992 Step-by-step protocol for making a knock-in Xenopus laevis to visualize endogenous gene expression

Kagawa, N.; Umesono, Y.; Suzuki, K.-i. T.; Mochii, M.

10.1101/2025.03.05.640691 — developmental biology — Posted on 2025-04-25

993 Cranial suture integrity is maintained by Fgfr3 in zebrafish

Pereur, R.; Marc, Y.; Lim, Y.; Schmitt, A.; Malbouyres, M.; Chessel, A.; Ruggiero, F.; Schanne-Klein, M.-C.; Legeai-Mallet, L.; Dambroise, E.

10.1101/2025.04.09.647929 — developmental biology — Posted on 2025-04-25

994 The triad interaction of ULK1, ATG13, and FIP200 is required for ULK complex formation and autophagy

Hama, Y.; Fujioka, Y.; Yamamoto, H.; Mizushima, N.; Noda, N. N.

10.1101/2024.08.02.606296 — cell biology — Posted on 2025-04-25

995 Subtle Cellular Phenotypes Inform Pathological and Benign Genetic Mutants in the Iduronidase-2 Sulfatase Gene

Viswanathan, A.; Elia, S. N.; Le, S. Q.; Hurt, S. C.; Doray, B.; Waligorski, J. E.; Kelley, K.; Buchser, W. J.; Dickson, P. I.

10.1101/2025.04.17.649412 — cell biology — Posted on 2025-04-25

996 Cannabidiol Reduces Oxycodone Self-Administration While Preserving Its Analgesic Efficacy in a Rat Model of Neuropathic Pain

Bruijnzeel, A.; Behnood-Rod, A.; Chellian, R.; Malphurs, W.; Caudle, R.; Febo, M.; Setlow, B.; Murphy, N.; Neubert, J.

10.1101/2025.04.21.649778 — pharmacology and toxicology — Posted on 2025-04-25

997 Shiny-Calorie: A context-aware application for indirect calorimetry data analysis and visualization using R

Grein, S.; Elschner, T.; Kardinal, R.; Bruder, J.; Strohmeyer, A.; Gunasekaran, K.; Witt, J.; Hermannsdottir, H.; Behrens, J.; U-Din, M.; Yu, J.; Heldmaier, G.; Schreiber, R.; Rozman, J.; Heine, M.; Scheja, L.; Worthmann, A.; Heeren, J.; Wachten, D.; Wilhelm-Juengling, K.; Pfeifer, A.; Hasenauer, J.; Klingenspor, M.

10.1101/2025.04.24.648116 — bioinformatics — Posted on 2025-04-25

998 Back to Basics: Spectrum and Peptide Sequence are Sufficient for Top-tier Mass Spectrometry Proteomics Identification

Burq, M.; Stepec, D.; Restrepo, J.; Zbontar, J.; Urazbakhtin, S.; Crampton, B.; Chinoy, R.; Tiwary, S.; Miao, M.; Cox, J.; Cimermancic, P.

10.1101/2024.08.19.606805 — bioinformatics — Posted on 2025-04-25

999 Herring roe PLs promote SPM biosynthesis in macrophages and a keratinocyte/fibroblast co-culture as model of psoriasis

Ringheim-Bakka, T. A.; Saliani, A.; Ostbye, T.-K. K.; Mildenberger, J.; Dooley, M.; Busygina, M.; Pedersen, M. E.; Solberg, N. T.; Dalli, J.; Gammelsaeter, R.

10.1101/2025.02.20.639253 — biochemistry — Posted on 2025-04-25

1000 BACE1 regulates sleep-wake cycle through both enzymatic and non-enzymatic actions.

Heininger, H.; Feng, X.; Altunkaya, A.; Zheng, F.; Stockinger, F.; Wefers, B.; Müller, S. A.; Giesbertz, P.; Tschirner, S. K.; Shqau, D.; Adelsberger, H.; Ponomarenko, A.; Fenzl, T.; Alzheimer, C.; Lichtenthaler, S. F.; Huth, T.

10.1101/2025.04.17.648898 — animal behavior and cognition — Posted on 2025-04-25

1001 A genome-guided atlas to the composition, activity, and β-bungarotoxin dimerization in many-banded krait venom inferred by functional venomics

Uhrig, L.; Avella, I.; Schulte, L.; Hurka, S.; Dersch, L.; Eichberg, J.; Schiffmann, S.; Henke, M.; Kuch, U.; Cabrera-Orefice, A.; Hardes, K.; Vilcinskas, A.; Damm, M.; Lueddecke, T.

10.1101/2025.04.22.649985 — molecular biology — Posted on 2025-04-25

1002 Immunity and bacterial recruitment in plant leaves are parallel processes that together shape sensitivity to temperature stress

Jose, J.; Teutloff, E.; Mayer, T.; Naseem, S.; Barth, E. T.; Halitschke, R.; Marz, M.; Agler, M. T.

10.1101/2024.06.10.598336 — microbiology — Posted on 2025-04-25

1003 Covalent anti-HIV compound that induces HIV-1 capsid multimerization and degradation decomposes the viral core

Nakamura, T.; Takamune, N.; Okumura, M.; Yasunaga, J.-i.; Sugiura, M.; Amano, M.

10.1101/2025.04.19.649630 — microbiology — Posted on 2025-04-25

1004 Tissue damage-induced axon injury-associated responses in sensory neurons: requirements, prevention, and potential role in persistent post-surgical pain

Rau, K. K.; Harrison, B. J.; Venkat, G.; Petruska, S. E.; Taylor, B.; Hill, C. E.; Petruska, J. C.

10.1101/2025.02.11.637320 — neuroscience — Posted on 2025-04-25

1005 Large-scale cortical networks are organised in structured cycles

van Es, M. W. J.; Higgins, C.; Gohil, C.; Quinn, A. J.; Vidaurre, D.; Woolrich, M. W.

10.1101/2023.07.25.550338 — neuroscience — Posted on 2025-04-25

1006 Human deep sleep facilitates faster cerebrospinal fluid dynamics linked to brain oscillations for sleep homeostasis and memory

Uji, M.; Li, X.; Saotome, A.; Katsumata, R.; Waggoner, R. A.; Suzuki, C.; Ueno, K.; Aritake, S.; Tamaki, M.

10.1101/2024.08.30.610454 — neuroscience — Posted on 2025-04-25

1007 Higher-order and distributed synergistic functional interactions encode information gain in goal-directed learning

Combrisson, E.; Basanisi, R.; Neri, M.; Auzias, G.; Petri, G.; Marinazzo, D.; Panzeri, S.; Brovelli, A.

10.1101/2024.09.23.614484 — neuroscience — Posted on 2025-04-25

1008 The inherent fragility of collective proliferative control

Caldwell, M. G.; Lander, A. D.

10.1101/2024.01.23.576783 — cancer biology — Posted on 2025-04-25

1009 PTEN neddylation aggravates CDK4/6 inhibitor resistance in breast cancer

Liu, F.; Liu, W.; Tan, Y.; Shang, Y.; Ling, S.; Jiang, X.; Zhang, Z.; Sun, S.; Xie, P.

10.1101/2024.08.06.606911 — cancer biology — Posted on 2025-04-25

1010 A Dual-Fluorescence Assay for Gene Delivery Vehicle Screening in Macrophages with an Inflammation-Inducible Reporter Construct

Ivy, A.; Bess, S. N.; Agrawal, S.; Kochar, V.; Stokes, A. L.; Muldoon, T. J.; Nelson, C. E.

10.1101/2024.08.05.606664 — bioengineering — Posted on 2025-04-25

1011 Biomechanical Evaluation of Temporomandibular Joint Implants and Periprosthetic Bone under Unilateral and Bilateral Clenching

Ghosh, R.; Chandra, G.; Verma, V.; Kaur, K.; Roychoudhury, A.; Mukherjee, S.; Chawla, A.; Mukherjee, K.

10.1101/2024.08.26.609607 — bioengineering — Posted on 2025-04-25

1012 Intracortical Microstimulation Induces Rapid Microglia Process Convergence

Williams, N. P.; Kelly, A. M.; Zheng, X. S.; Vazquez, A. L.; Cui, X. T.

10.1101/2025.03.13.643075 — bioengineering — Posted on 2025-04-25

1013 Directing stem cell differentiation by chromatin state approximation

Montano-Gutierrez, L. F.; Mueller, S.; Kutschat, A. P.; Seruggia, D.; Halbritter, F.

10.1101/2025.04.24.650451 — genomics — Posted on 2025-04-25

1014 A Single-Cell Atlas Of Human Pediatric Liver Reveals Age-Related Hepatic Gene Signatures

Edgar, R. D.; Nakib, D.; Camat, D.; Chung, S.; Lumanto, P.; Atif, J.; Perciani, C. T.; Ma, X. Z.; Thoeni, C.; Selvakumaran, N.; Manuel, J.; Sayed, B.; Huysentruyt, K.; Ricciuto, A.; McGilvray, I.; Avitzur, Y.; Bader, G. D.; MacParland, S. A.

10.1101/2025.04.16.649149 — genomics — Posted on 2025-04-25

1015 Genomics of freshwater adaptation in threespine stickleback from eastern Canada

Garcia-Elfring, A.; Salamon, M.; Paccard, A.; Barrett, R. D. H.

10.1101/2025.04.18.649616 — genomics — Posted on 2025-04-25

1016 DNA Methylation Dynamics of Dose-dependent Acute Exercise, Training Adaptation, and Detraining

Hariharan, M.; Patel, S.; Song, H.; Rehman, A.; Barragan, C.; Bartlett, A.; Castanon, R.; Nery, J.; Rothenberg, V.; Chen, H.; Tian, W.; Ding, W.; Wang, W.; McAdam, J.; Graham, Z.; Lavin, K.; Bamman, M.; Broderick, T.; Ecker, J.

10.1101/2025.04.22.650067 — genomics — Posted on 2025-04-25

1017 Ancient co-option of LTR retrotransposons as yeast centromeres

Haase, M. A. B.; Lazar-Stefanita, L.; Baudry, L.; Wudzinska, A.; Zhou, X.; Rokas, A.; Hittinger, C. T.; Musacchio, A.; Boeke, J. D.

10.1101/2025.04.25.647736 — evolutionary biology — Posted on 2025-04-25

1018 Adaptations in wing morphology rather than wingbeat kinematics enable flight in small hoverfly species

Le Roy, C.; Tervelde, N.; Engels, T.; Muijres, F.

10.1101/2024.04.08.588585 — evolutionary biology — Posted on 2025-04-25

1019 Chromatin regulator HELLS mediates SSB repair and responses to DNA alkylation damage.

Joseph, J. T.; Wright, C. M.; Peixoto, E.; Khan, A.; Li, Y.; Neidigk, J. S. R.; Decker, O.; Kadali, K. R.; Imtiaz, A.; Jones, B. A.; Zhang, Y.; Shibata, E.; Gradilone, S.; Lewis, Z. A.; Contreras, R.; Sen, A.; Dutta, A.; Czaja, W.

10.1101/2024.12.19.629292 — molecular biology — Posted on 2025-04-25

1020 Specific origin selection and excess functional MCM2-7 loading in ORC-deficient cells.

Shibata, Y.; Peycheva, M.; Shibata, E.; Malzl, D.; Pavri, R.; Dutta, A.

10.1101/2024.10.30.621095 — molecular biology — Posted on 2025-04-25

1021 Malnutrition drives infection susceptibility and dysregulated myelopoiesis that persists after refeeding intervention

Sukhina, A.; Queriault, C.; Roy, S.; Hall, E.; Rome, K.; Aggarwal, M.; Nunn, E.; Weiss, A.; Nguyen, J.; Bennett, F. C.; Bailis, W.

10.1101/2024.08.19.608575 — immunology — Posted on 2025-04-25

1022 Accumbal acetylcholine signals associative salience during learning

Zhang, Z.; Costa, K. M.; Zhuo, Y.; Li, G.; Li, Y.; Schoenbaum, G.

10.1101/2025.01.06.631529 — neuroscience — Posted on 2025-04-25

1023 Neural evidence that humans reuse strategies to solve new tasks

Hall-McMaster, S.; Tomov, M. S.; Gershman, S. J.; Schuck, N. W.

10.1101/2024.06.10.598294 — neuroscience — Posted on 2025-04-25

1024 Heterogeneous therapy-resistant cancer cells have distinct and exploitable drug sensitivity profiles

Busch, G. T.; Boe, R. H.; Li, J.; Gruener, R. F.; Arnett, M. J.; Ravindran, P. T.; Herlyn, M.; Huang, R. S.; Raj, A.

10.1101/2025.04.25.650475 — systems biology — Posted on 2025-04-25

1025 A microbiome-derived nutrient underlies tyrosine metabolism and predator avoidance in mosquito larvae

Kelley, M.; Rathore, S.; Chandrasegaran, K.; Herbert, C.; Sabile, C. E. G.; Wood, T.; Joves, J.; Palacios, A.; Susanto, E.; Uhran, M.; Ramirez, A. L.; Chen, S.-C.; Tompkin, J.; Singh, K.; Khalid, M. S.; Vinauger, C.; Buschbeck, E.; Limbach, P. A.; Benoit, J. B.

10.1101/2025.04.02.646203 — physiology — Posted on 2025-04-25

1026 Deep visual multi-omics profiling reveals mechanisms that underlie cancer cell differentiation and aggressiveness in clear cell renal cell carcinoma

Bolck, H. A.; Migh, E.; Kriston, A.; Zajac, N.; Kreutzer, S.; Totu, T.; Leary, P.; Kovacs, F.; Rutishauser, D.; Pfammatter, S.; Grossmann, J.; Litchfield, C.; Buljan, M.; Rupp, N. J.; Horvath, P.; Moch, H.

10.1101/2025.01.31.635927 — cancer biology — Posted on 2025-04-25

1027 Coral anthozoan-specific opsins employ a novel chloride counterion for spectral tuning

Sakai, Y.; Sen, S.; Sugihara, T.; Kakeyama, Y.; Iwasaki, M.; Schertler, G.; Deupi, X.; Koyanagi, M.; Terakita, A.

10.1101/2024.12.12.628111 — biophysics — Posted on 2025-04-25

1028 Predicting Biological Age Using an Accumulated Neurotoxicity Biomarker for Amyloid Beta Oligomers

Kuznetsov, A. V.

10.1101/2025.02.28.640920 — biophysics — Posted on 2025-04-25

1029 A benchmark for large language models in bioinformatics

Sarwal, V.; Andreoletti, G.; Munteanu, V.; Suhodolschi, A.; Ciorba, D.; Bostan, V.; Dimian, M.; Eskin, E.; Wang, W.; Mangul, S.

10.1101/2023.12.19.572483 — bioinformatics — Posted on 2025-04-25

1030 BindCraft: one-shot design of functional protein binders

Pacesa, M.; Nickel, L.; Schellhaas, C.; Schmidt, J.; Pyatova, E.; Kissling, L.; Barendse, P.; Choudhury, J.; Kapoor, S.; Alcaraz-Serna, A.; Cho, Y.; Ghamary, K. H.; Vinue, L.; Yachnin, B. J.; Wollacott, A. M.; Buckley, S.; Westphal, A. H.; Lindhoud, S.; Georgeon, S.; Goverde, C. A.; Hatzopoulos, G. N.; Gonczy, P.; Muller, Y. D.; Schwank, G.; Swarts, D. C.; Vecchio, A. J.; Schneider, B. L.; Ovchinnikov, S.; Correia, B. E.

10.1101/2024.09.30.615802 — bioinformatics — Posted on 2025-04-25

1031 HybriSeq: Probe-based Device-free Single-cell RNA Profiling

Foyt, D.; Brown, D.; Zhou, S.; Moser, B.; Zhu, Q.; Gartner, Z. J.; Huang, B.

10.1101/2023.09.27.559406 — bioengineering — Posted on 2025-04-25

1032 Subcellular proteomics of Paramecium tetraurelia reveals mosaic localization of glycolysis and gluconeogenesis

Jirsova, D.; Licknack, T.; Poh, Y.-P.; Qiu, Y.; Quan, N.; Karr, T.; Chou, T.-F.; Lynch, M.; Wideman, J. G.

10.1101/2025.04.24.650466 — cell biology — Posted on 2025-04-25

1033 A Dual Homeostatic Regulation of Dry Mass and Volume Defines a Target Density in Proliferating Mammalian Cells

Srivastava, N.; Calabrese, L.; Plancke, C.; Rollin, R.; Venkova, L.; Havas, K.; Cosentino Lagomarsino, M.; Piel, M.

10.1101/2025.04.24.650395 — cell biology — Posted on 2025-04-25

1034 Elevated GLUT4 Levels in Human Skeletal Muscle Microtissues is Accompanied by Functional Insulin Dependence

Tiper, Y.; Ni, J.; Krawetz, R.; Gilbert, P. M.

10.1101/2025.04.24.650438 — cell biology — Posted on 2025-04-25

1035 Aging changes the underlying mechanism of JAK2 modulation in neutrophil function

Feldmann, J. W.; Kays, M.; McGinnis, F.; Herron, E.; Sati, N.; Woods, C.; Coulibaly, A.

10.1101/2025.04.21.649782 — immunology — Posted on 2025-04-25

1036 Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy

Kapoor, R.; Kim, H.; Garlick, E.; Lima, M. A. d. R. B. F.; Ruhwedel, T.; Moebius, W.; Wolf, F.; Moser, T.

10.1101/2025.04.22.649963 — neuroscience — Posted on 2025-04-25

1037 Personalized Biomarkers of Multiscale Functional Alterations in Temporal Lobe Epilepsy

Xie, K.; Sahlas, E.; Ngo, A.; Chen, J.; Arafat, T.; Royer, J.; Zhou, Y.; Rodriguez-Cruces, R.; Dascal, A.; Caldairou, B.; Fadaie, F.; Barnett, A.; Audrain, S.; Lariviere, S.; Caciagli, L.; Pana, R.; Weil, A. G.; Grova, C.; Frauscher, B.; Schrader, D. V.; Zhang, Z.; Concha, L.; Bernasconi, A.; Bernasconi, N.; Bernhardt, B. C.

10.1101/2025.04.24.650457 — neuroscience — Posted on 2025-04-25

1038 The representation of mood in primate anterior insular cortex

Rust, N. C.; Yang, Y.-P. C.; Hacker, C. M.; Stuphorn, V.

10.1101/2025.04.22.650010 — neuroscience — Posted on 2025-04-25

1039 Modeling dynamic inflow effects in fMRI to quantify cerebrospinal fluid flow

Ashenagar, B.; Gomez, D. E. P.; Lewis, L. D.

10.1101/2025.04.03.647027 — neuroscience — Posted on 2025-04-25

1040 A modelling assessment for the impact of control measures on highly pathogenic avian influenza transmission in poultry in Great Britain

Davis, C. N.; Hill, E. M.; Jewell, C. P.; Rysava, K.; Thompson, R. N.; Tildesley, M. J.

10.1101/2025.04.24.650264 — systems biology — Posted on 2025-04-25

1041 Modeling human phenotypes in the nematode C. elegans during an undergraduate developmental biology course

The Augsburg BIO474 Consortium, ; Aburaide, S.; Ahmed, S.; Chamberlain, M.; Deleon, Y.; Elewa, A.; Millan, L.; Hookom, A.; Juen, E.; Katasi, D.; Lee, B.; Meyer, S.; Shaw, M.; Smith, D.; Vassallo, A.; Wangmo, T.; Wolfson, D.; Xiong, P.; Yaeger, L.

10.1101/2025.04.23.650323 — scientific communication and education — Posted on 2025-04-25

1042 On-cell Saturation Transfer Difference (STD) NMR on ion channels: characterizing negative allosteric modulator binding interactions of P2X7.

Monaco, S.; Browne, J.; Wallace, M.; Angulo, J.; Stokes, L.

10.1101/2025.04.22.649959 — pharmacology and toxicology — Posted on 2025-04-25

1043 TIGIT expression dictates the immunosuppressive reprogramming of myeloid cells in glioblastoma

Asad, M.; Inocencio, J.; Mitrasinovic, S.; Aoki, M.; Crisman, C.; Lasala, P.; Eskandar, E.; Guha, C.; Zang, X.; Parney, I. F.; Himes, B. T.

10.1101/2025.04.24.648993 — cancer biology — Posted on 2025-04-25

1044 Repurposing Quetiapine as an Adjuvant Therapeutic Agent for Triple-Negative Breast Cancer

He, L.; Joshi, P.; Ioannidis, A.; Kathiravan, A.; Saki, M.; Pajonk, F.

10.1101/2025.04.24.650517 — cancer biology — Posted on 2025-04-25

1045 Fluorescence Characterization of Extracellular Vesicles using Single-Molecule Confocal Microscopy

Zhao, T.; Pelegrina-Hidalgo, N.; Edwards, D. C.; Bak, K. M.; Karmakar, U.; Fernando, A. J.; Vendrell, M.; Rossi, A. G.; Kunath, T.; Cockroft, S. L.; Saleeb, R. S.; Horrocks, M. H.

10.1101/2025.04.21.649767 — biophysics — Posted on 2025-04-25

1046 MiT4SL: multi-omics triplet representation learning for cancer cell line-adapted prediction of synthetic lethality

Tao, S.; Feng, Y.; Yang, Y.; Wu, M.; Zheng, J.

10.1101/2025.04.20.649694 — bioinformatics — Posted on 2025-04-25

1047 Epithelial fusion is mediated by a partial epithelial-mesenchymal transition

Tamilkumar, V. N.; Purushothama, H.; Ladher, R. K.

10.1101/2025.04.21.649757 — developmental biology — Posted on 2025-04-25

1048 Tumour-derived Ilp8 and Upd3 control intestinal progenitor cells depletion during cachexia in Drosophila larvae

Falconi, J.; Rodriguez-Vazquez, M.; Strobel, K.; Jahannault-Talignani, C.; Heron-Milhavet, L.; Lassus, P.; Geminard, C.; Djiane, A.

10.1101/2025.04.21.649791 — developmental biology — Posted on 2025-04-25

1049 OCT4 Negatively Regulates the Transcriptional Programming of the Early Region 3 Immune Evasion Genes of Human Adenovirus

Ismail, A. M.; Saha, A.; Morrissey, K. A.; Lundquist, D.; Garcia, E.; Balne, P.; Cannon, J. L.; Chodosh, J.; Rajaiya, J.

10.1101/2025.04.23.650321 — cell biology — Posted on 2025-04-25

1050 Dystrophin Dp71 is essential for the development and function of macrophages

Chira, N.; Swatler, J.; Manousopoulou, A.; Rumney, R. M. H.; Hajto, J.; Oksiejuk, A.; Garay Baquero, D. J.; Rog, J.; White, C. H.; Hinz, S.; Alnassar, N.; Young, C.; Arkle, S.; Korostynski, M.; Kozlowska, E.; Garbis, S. D.; Gorecki, D. C.

10.1101/2025.04.24.650386 — cell biology — Posted on 2025-04-25

1051 Integrins and tetraspanins mediate CD36-actin coupling and regulate CD36 organization and signaling

Jana, S.; Ngo, H.-T.; Guerrero, J.; Vega-Lugo, J.; Dasgupta, A.; Jaqaman, K.

10.1101/2025.04.24.650515 — cell biology — Posted on 2025-04-25

1052 Abnormal Lipid Metabolism and Altered Neuronal Support by Astrocytes Lacking Akap11, a Risk Gene for Schizophrenia and Bipolar Disorder

Liu, X.-M.; Pribiag, H.; Misri, D.; Kim, K.; Mandell, K. P.; Song, B. J.; Graykowski, D.; Seidel, O.; Hartley, N. D.; Herrera, M.; Xu, H. J.; Tegtmeyer, M.; Zhang, Y.-L.; Cui, L.; Clark, N.; Huang, W.-C.; Adeleye, J.; Dennis, C.; Dailey, L.; Deik, A.; Inunciaga, L.; Mashin, E.; Simmons, S. K.; Pan, J. Q.; Nehme, R.; Keshishian, H.; Carr, S. A.; Fu, Z.; Levin, J. Z.; Clish, C. B.; Sheng, M.

10.1101/2025.04.25.650548 — cell biology — Posted on 2025-04-25

1053 The cytokinesis associated proteins CITK and ASPM-1 regulate neuronal microtubule dynamics and polarity in C. elegans

Sharma, S.; Ponniah, K.; Ghosh-Roy, A.

10.1101/2025.04.24.650367 — cell biology — Posted on 2025-04-25

1054 Targeting ROCK Signaling Mitigates Influenza Virus-Induced Fibrogenesis in Human Airway Organoids

ROTHAN, H.; Mostafa, A.; Bayoumi, M.; Ye, C.; Barre, R.; Allue Guardia, A.; Nogales, A.; Torrelles, J. B.; Martinez-Sobrido, L. B.

10.1101/2025.04.21.649854 — microbiology — Posted on 2025-04-25

1055 Familial Alzheimers disease mutations impair neutrophil phagocytosis and release of immune modulators

Kays, M.; Kelly, A.; McGinnis, F.; Woods, C.; Brown, C.; Coulibaly, A.

10.1101/2025.04.21.649766 — immunology — Posted on 2025-04-25

1056 Immune Composition of the Mononuclear Cell Fraction of Human Umbilical Cord Blood

Kikuta, K.; Lee, E.; Menezes, T.; Fung, H. F.; Amorin, A.; Agrawal, A.; Roth, T.; Porteus, M.

10.1101/2025.04.21.649733 — immunology — Posted on 2025-04-25

1057 Neural trajectories reveal orchestration of cortical coding underlying natural language composition

Tang, X.; Booth, J. R.; Zhang, Y.; Wang, S.; Ding, G.

10.1101/2025.04.24.650382 — neuroscience — Posted on 2025-04-25

1058 G protein-coupled receptor 35 (GPR35) stimulation reduces osteoclast activity in primary human bone cells

Price, M.; Wyatt, R.; Crastin, A.; Jamaluddin, A.; Hardy, R.; Frost, M.; Gorvin, C. M.

10.1101/2025.04.21.649743 — pharmacology and toxicology — Posted on 2025-04-25

1059 WITHDRAWN: Streptococcus mutans inhibits the growth of Enterococcus via the non-ribosomal cyclic peptide mutanobactin

Willett, J.; Robertson, E. B.

10.1101/2023.09.12.557362 — microbiology — Posted on 2025-04-25

1060 Abundant Recurrent Mitochondrial Mutations and Widespread Mitonuclear Epistasis in Caenorhabditis elegans

Nguyen, T. H.; Klein, D. A.; Weklar, O. S.; Wengrow, E. R.; Rockman, M. V.

10.1101/2025.04.22.650036 — evolutionary biology — Posted on 2025-04-25

1061 Modulation of aperiodic EEG activity provides sensitive index of cognitive state changes during working memory task

Frelih, T.; Matkovic, A.; Mlinaric, T.; Bon, J.; Repovs, G.

10.1101/2024.05.13.593835 — neuroscience — Posted on 2025-04-25

1062 Genomic erosion through the lens of comparative genomics

Wang, X.; Fontsere, C.; Caballero, X. A.; Nielsen, S. D.; Groombridge, J.; Hansson, B.; van Oosterhout, C.; Pacheco, C.; Morales, H. E.

10.1101/2025.03.28.645899 — genomics — Posted on 2025-04-24

1063 Diverging transposon activity among polar bear sub-populations inhabiting different climate zones

Godden, A. M.; Rix, B. T.; Immler, S.

10.1101/2024.12.04.626794 — evolutionary biology — Posted on 2025-04-24

1064 Systematic analysis of CDR contacts and sequence constraints between T cell receptor αβ chains.

Milighetti, M.; Nagano, Y.; Henderson, J.; Hershberg, U.; Tiffeau-Mayer, A.; Bitbol, A.-F.; Chain, B.

10.1101/2024.05.24.595718 — immunology — Posted on 2025-04-24

1065 Hebb's Vision: The Structural Underpinnings of Hebbian Assemblies

Wagner-Carena, J. A.; Kate, S.; Riordan, T.; Abbasi-Asl, R.; Aman, J.; Amster, A.; Bodor, A. L.; Brittain, D.; Buchanan, J.; Buice, M. A.; Bumbarger, D. J.; Collman, F.; da Costa, N. M.; Denman, D. J.; de Vries, S. E.; Joyce, E.; Kapner, D.; King, C. W.; Larkin, J. D.; Lecoq, J.; Mahalingam, G.; Millman, D.; Molter, J.; Morrison, C.; Reid, R. C.; Schneider-Mizell, C. M.; Daniel, S.; Suckow, S.; Takasaki, K. T.; Torres, R.; Vumbaco, D.; Waters, J.; Wyrick, D. G.; Yin, W.; Zhuang, J.; Takeno, M.; Mihalas, S.; Berteau, S.

10.1101/2025.04.24.649900 — neuroscience — Posted on 2025-04-24

1066 Cortex-wide voltage imaging in a sensory cued reaching task reveals fast subnetwork dynamics

Wang, Y.; Kim, S. H.; He, E. J.; Le Chatelier, B.; Choi, H.; Jaeger, D.

10.1101/2025.04.24.650533 — neuroscience — Posted on 2025-04-24

1067 Early synaptic changes and reduced brain connectivity in PD-like mice with depressive phenotype

Bortolozzi, A.; Miquel Rio, L.; Jerico-Escolar, J.; Sarries-Serrano, U.; Yanes-Castilla, C.; Paz, V.; Torres-Lopez, M.; Argibay, U.; Munoz, E.; Lopez-Gil, X.

10.1101/2025.04.24.650442 — neuroscience — Posted on 2025-04-24

1068 Dopamine Dynamics in the Nucleus Accumbens Reflect Confidence in Detecting the Occurrence and Non-Occurrence of Visual Signals in Perceptual Decision-Making

Wilod Versprille, L. J. F.; McKenzie, C.; Amorim, F. E.; Yano, K.; Dalley, J. W.; Robbins, T. W.

10.1101/2025.04.24.650502 — neuroscience — Posted on 2025-04-24

1069 Tracking neural representations of attended and unattended features in multisensory working memory over time

Arslan, C.; Schneider, D.; Getzmann, S.; Wascher, E.; Klatt, L.-I.

10.1101/2025.04.24.650418 — neuroscience — Posted on 2025-04-24

1070 Characterization of Human Anterior Neural Organoids as a Model for Investigating Cohen Syndrome

Prasad, R.; Lee, J.-H.; Lee, D.-Y.; Lee, Y.; Lee, J.; Park, S.-H.; Ryu, J. R.; Lee, B.; Choi, S.; Choi, J.; Cho, I.-J.; An, J.-Y.; Vacca, F.; Ansar, M.; Kim, H. J.; Kim, M.; Sun, W.

10.1101/2025.04.23.650357 — neuroscience — Posted on 2025-04-24

1071 Activity deprivation modulates the Shank3/Homer1/mGluR5 signaling pathway to enable synaptic upscaling

Guerrero, A. A.; Turrigiano, G.

10.1101/2025.04.24.650518 — neuroscience — Posted on 2025-04-24

1072 Influence of social and semantic contexts on phonetic encoding in naturalistic conversations

Abassi, E.; Zatorre, R.

10.1101/2024.01.10.575068 — neuroscience — Posted on 2025-04-24

1073 PS Poly: A chain tracing algorithm to determine persistence length and categorize complex polymers by shape

Conley, E. A.; Lisowski, C. M.; Schaefer, K. G.; Davison, H. C.; Baguio, J.; Kosztin, I.; King, G.

10.1101/2024.05.06.592664 — biophysics — Posted on 2025-04-24

1074 Reference-guided genome assembly at scale using ultra-low-coverage high-fidelity long-reads with HiFiCCL

Jiang, Z.; Pan, W.; Gao, R.; Hu, H.; Gao, W.; Zhou, M.; Yin, Y.-H.; Qian, Z.; Jin, S.; Wang, G.

10.1101/2025.04.20.649739 — bioinformatics — Posted on 2025-04-24

1075 K5 polysaccharides inhibit SARS-CoV-2 infection by preventing spike-proteolytic priming

Milanesi, M.; Urbinati, C.; Zimmermann, L.; Oreste, P.; Zani, A.; Caruso, A.; Caccuri, F.; Laketa, V.; Chlanda, P.; Wade, R. C.; Rusnati, M.; Paiardi, G.

10.1101/2025.04.23.650164 — biochemistry — Posted on 2025-04-24

1076 Targeted long-read RNA sequencing reveals the complexity of CLN3 transcription and the consequences of the most common 1-kb deletion in patients with juvenile CLN3 disease

Minnis, C. J.; Zhang, H.-Y.; Gustavsson, E.; Lee, J.; Anderson, C.; Gardner, E.; Schulz, A.; Nickel, M.; Arno, G.; Jurkute, N.; Webster, A. R.; Gammaldi, N.; Santorelli, F. M.; Gissen, P.; Mills, P.; Ryten, M.; Mole, S. E.

10.1101/2025.04.24.650398 — genetics — Posted on 2025-04-24

1077 Parallel evolution of full-length genomes in a long-term evolution experiment with phage ΦX174

Bons, E.; Chabas, H.; MacDonald, H.; Escalera Ledermann, A.; Ochsner, N.; Angst, D. C.; Bonhoeffer, S.; Regoes, R. R.

10.1101/2025.04.22.649699 — evolutionary biology — Posted on 2025-04-24

1078 Effects of priority on strain-level composition of the honey bee gut community

Jones, K. R.; Song, Y.; Rinaldi, S. S.; Moran, N. A.

10.1101/2025.04.21.649814 — ecology — Posted on 2025-04-24

1079 Group size influences behavioral plasticity in responses to thermoregulation-foraging trade-offs by a socially cohesive bird

Rozen-Rechels, D.; Papageorgiou, D.; Ogino, M.; Nyaguthii, B.; Buschhausen, N.; Hansen Wheat, C.; Klarevas-Irby, J. A.; Njoroge, P.; Farine, D. R.

10.1101/2025.04.24.650232 — ecology — Posted on 2025-04-24

1080 Complementary cortical and striatal encoding of locomotor preparation and performance

Singla, D.; Yang, L.; Weakley, A. S.; Davidoff, D.; Kao, J. C.; Masmanidis, S. C.

10.1101/2025.04.24.650464 — neuroscience — Posted on 2025-04-24

1081 A genome-guided atlas to the composition, activity, and β-bungarotoxin dimerization in many-banded krait venom inferred by functional venomics

Uhrig, L.; Avella, I.; Schulte, L.; Hurka, S.; Dersch, L.; Eichberg, J.; Schiffmann, S.; Henke, M.; Kuch, U.; Cabrera-Orefice, A.; Hardes, K.; Vilcinskas, A.; Damm, M.; Lueddecke, T.

10.1101/2025.04.22.649985 — molecular biology — Posted on 2025-04-24

1082 The receptor binding properties of H5Nx influenza A viruses have evolved to promiscuously bind to avian-type mucin-like O-glycans

Weber, J.; Ponse, N. L. D.; Zhu, X.; Rios Carrasco, M.; Han, A. X.; Funk, M.; Lin, T.-H.; Gabarroca Garcia, A.; Spruit, C. M.; Yu, W.; Zhang, D.; Wilson, I. A.; Richard, M.; Boons, G.-J.; de Vries, R. P.

10.1101/2025.04.24.650378 — microbiology — Posted on 2025-04-24

1083 A refined low-dose murine model of Mycobacterium ulcerans infection to assess integrated immune networks in Buruli ulcer pathogenesis

Muhi, S.; Foo, I. J. H.; Kedzierski, L.; Porter, J. L.; McQuilten, H. A.; Howden, B.; Kedzierska, K.; Buultjens, A. H.; Chua, B. Y.; Stinear, T. P.

10.1101/2025.04.23.650345 — microbiology — Posted on 2025-04-24

1084 COVID-19 in Space: Possible Health Risks and Preparedness Guidelines

Vashishat, I.; Han, E.; Assogba, B. D.

10.1101/2025.04.23.650113 — microbiology — Posted on 2025-04-24

1085 Cell cycle-coupled transcriptional network orchestrates human B cell fate bifurcation

Pease, N. A.; Fan, J.; Keshari, S.; Stratton, J.; Gerges, P.; Ann Varghese, B.; Nampoothiri VP, N.; McGinnnis, C. S.; Zhang, W.; Geirlack, S. B.; Swaminathan, T.; Sachan, A.; Manakkat Vijay, G.; Mena Hernandez, L.; Heidari Rarani, Z.; Macedo, C.; Metes, D.; Satpathy, A. T.; Jain, A. K.; Sahni, N.; Stallaert, W.; Das, J.; Singh, H.

10.1101/2025.04.23.649973 — immunology — Posted on 2025-04-24

1086 Large Language Models Reveal the Neural Tracking of Linguistic Context in Attended and Unattended Multi-Talker Speech

Puffay, C.; Mischler, G.; Choudhari, V.; Vanthornhout, J.; Bickel, S.; Mehta, A. D.; Schevon, C. A.; McKhann, G. M.; Van hamme, H.; Francart, T.; Mesgarani, N.

10.1101/2025.04.24.648897 — neuroscience — Posted on 2025-04-24

1087 Engineering microbial consortia for distributed signal processing

Duncker, K. E.; Shende, A. R.; Shyti, I.; Ruan, A.; D'Cunha, R.; Ma, H. R.; Venugopal Lavanya, H.; Liu, S.; Gottel, N.; Anderson, D. J.; Gunsch, C. K.; You, L.

10.1101/2025.04.23.650302 — synthetic biology — Posted on 2025-04-24

1088 Engineered isoprene production from Chlamydomonas reinhardtii using herbicide selection markers and CO2-fed cultivation optimization through multi-parallel photobioreactor headspace gas analysis

Yahya, R. Z.; Overmans, S.; Wellman, G. B.; Lauersen, K. J.

10.1101/2025.04.22.649625 — bioengineering — Posted on 2025-04-24

1089 Structural insight into the substrate binding of the AMT complex via an inhibitor-trapped state

Shao, Z.; Yoon, S.; Lu, J.; Athavale, P.; Liu, Y.; Song, J.

10.1101/2025.04.24.650485 — biochemistry — Posted on 2025-04-24

1090 Effects of NAD⁺ Repletion with Nicotinamide Riboside on Obesity-Induced Chronic Kidney Disease and Renal Cell Lipotoxicity

Decarnoncle, M.; Pierre, L.; Rouze, P.; Jadot, I.; Decleves, A.-E.; Juszczak, F.

10.1101/2025.04.22.649334 — biochemistry — Posted on 2025-04-24

1091 The co-receptors Orco and Ir8a are required for coordinated expression of chemosensory genes in the antennae of the yellow fever mosquito, Aedes aegypti.

Cooke, M. M.; Chembars, M. S.; Pitts, R. J.

10.1101/2025.04.23.650034 — molecular biology — Posted on 2025-04-24

1092 Deciphering ESR1-driven transcription in human endometrial stromal cells via transcriptome, cistrome, and integration with chromatin landscape

Montague Redecke, S. G.; Bell-Hensley, A.; Li, S.; Jain, A.; Massri, A. J.; DeMayo, F. J.

10.1101/2025.04.23.650343 — molecular biology — Posted on 2025-04-24

1093 Global mapping of thioredoxin interacting proteins in Neurospora crassa

Bidondo, L.; Drula, E.; GAILLARD, j.-c.; Armengaud, J.; Berrin, J.-G.; Rosso, M.-N.; Tarrago, L.

10.1101/2025.04.24.650474 — microbiology — Posted on 2025-04-24

1094 Rapid Assembly and Functional Differentiation of the Soil Surface Microbiome in Temperate Agricultural soil

O'Grady, C. J.; Hilton, S.; Picot, E.; Raguideau, S.; Quince, C.; van der Gast, C.; Bending, G. D.

10.1101/2025.04.24.650463 — microbiology — Posted on 2025-04-24

1095 Farmed oyster mortality follows consistent Vibrio community reorganization

Smith, S.; Ciesielski, M.; Clerkin, T.; Ben-Horin, T.; Noble, R. T.

10.1101/2025.04.24.650482 — microbiology — Posted on 2025-04-24

1096 Harnessing machine learning to predict antibiotic susceptibility in Pseudomonas aeruginosa biofilms

Vergauwe, F.; De Waele, G.; Sass, A.; Highmore, C.; Hanrahan, N.; Cook, Y.; Lichtenberg, M.; Cnockaert, M.; Vandamme, P.; Mahajan, S.; Webb, J.; Van Nieuwerburgh, F.; Bjarnsholt, T.; Waegeman, W.; Coenye, T.

10.1101/2025.04.24.650389 — microbiology — Posted on 2025-04-24

1097 Undecaprenyl Pyrophosphate Phosphatase (UppP) is a pivotal element in Salmonella Intramacrophage Survival

Vij, R.; Mukherjee, D.; Parmar, K.; Chakravortty, D.

10.1101/2025.04.24.650467 — microbiology — Posted on 2025-04-24

1098 Rab11B is required for binding and entry of recent H3N2, but not H1N1, influenza A isolates

Turner, A. H.; Jaffrani, S. A.; Kubinski, H. C.; Ajayi, D. P.; Owens, M. B.; McTigue, M. P.; Fanuele, C. D.; Appenzeller, C. L.; Despres, H. W.; Schmidt, M. M.; Crothers, J. W.; Bruce, E. A.

10.1101/2025.04.23.650275 — microbiology — Posted on 2025-04-24

1099 Improving Seedling Survival for Forest Restorations: A Novel Screening Method to Identify Microbial Allies Against Drought Stress

Magosch, S.; Barrera, C.; Boelz, A.; Pritsch, K.; Rothballer, M.; Benz, J. P.

10.1101/2025.04.24.650507 — microbiology — Posted on 2025-04-24

1100 Positive cooperativity between RAS-binding and cysteine-rich domains regulates RAF membrane binding kinetics via lateral rebinding

Jimenez Salinas, A.; Tevdorashvili, K.; Grim, J.; Morales, A.; Chakhrakia, A.; Lee, Y. K.

10.1101/2025.04.23.650295 — biochemistry — Posted on 2025-04-24

1101 Nickel-NTA lipid-monolayer affinity grids allow for high-resolution structure determination by cryo-EM

Skrajna, A.; Robinson, E.; Cannon, K.; Sarsam, R.; Ouellette, R. G.; Brennwald, P.; McGinty, R. K.; Strauss, J. D.; Baker, R. W.

10.1101/2025.04.24.650495 — biochemistry — Posted on 2025-04-24

1102 Giardia duodenalis: Base excision repair pathway enzyme FEN1 carries out catalytic activities pertaining to NER pathway

Garcia-Lepe, U. O.; Tomas-Morales, S. G.; Izaguirre-Hernandez, M. T.; Bazan-Tejeda, M. L.; Bermudez-Cruz, R. M.

10.1101/2025.04.23.650334 — biochemistry — Posted on 2025-04-24

1103 Ancestral evolution of oxidase activity in a class of (S)-nicotine and (S)-6-hydroxynicotine degrading flavoenzymes

Zhang, Z.; Bandivadekar, P.; Gaunt, A.; Ahn, S.-H.; Barkman, T.; Stull, F.

10.1101/2025.04.24.649827 — biochemistry — Posted on 2025-04-24

1104 Structural Genomic Variation Underlying Deer Speciation

Azimi Chetabi, F.; Shafer, A.

10.1101/2025.04.23.650217 — evolutionary biology — Posted on 2025-04-24

1105 Hangover regulates gene expression by limiting NSL-mediated H4K16 acetylation

Lenz, J.; Schmelzer, L.; Forne, I.; Nist, A.; Imhof, A.; Stiewe, T.; Brehm, A.

10.1101/2025.04.22.649938 — molecular biology — Posted on 2025-04-24

1106 The architecture of membrane structures involved in hepatitis C virus genome replication revealed in close-to-native conditions by cryo-electron tomography

Sykora, U.; O'Sullivan, T. J.; Halfon, Y.; Fontana, J.; Harris, M.

10.1101/2025.04.24.650446 — microbiology — Posted on 2025-04-24

1107 Impact of Species and Cell-type on the RNA Replication Kinetics of Seoul Virus

LaPointe, A. T.; Klimaj, S. D.; Kell, A. M.

10.1101/2025.04.24.650411 — microbiology — Posted on 2025-04-24

1108 Discovery of a novel antibiotic class targeting the enolase of Acinetobacterbaumannii

Molina Panadero, I.; Moreno Rodriguez, A.; de la Cruz, M.; Sanchez, P.; Tomas Gallardo, L.; Samernate, T.; Sencanski, M.; Glisic, S.; Genilloud, O.; Nonejuie, P.; Perez Pulido, A. J.; Hmadcha, A.; Smani, Y.

10.1101/2025.04.23.650324 — microbiology — Posted on 2025-04-24

1109 Apparent cooperativity between human CMV virions introduces errors in conventional methods of calculating multiplicity of infection

Peterson, C.; Miller, J.; Ryckman, B. J.; Ganusov, V. V.

10.1101/2025.04.23.650360 — microbiology — Posted on 2025-04-24

1110 AI-Based Antibody Design Targeting Recent H5N1 Avian Influenza Strains

Santolla, N. F.; Ford, C. T.

10.1101/2025.04.24.650061 — synthetic biology — Posted on 2025-04-24

1111 Lipid flip flop regulates the shape of growing and dividing synthetic cells

Lira, R. B.; Dekker, C.

10.1101/2025.04.23.650179 — synthetic biology — Posted on 2025-04-24

1112 High-throughput engineering and modification of non-ribosomal peptide synthetases based on Golden Gate assembly

Podolski, A.; Lindeboom, T. A.; Praeve, L.; Kranz, J.; Schindler, D.; Bode, H. B.

10.1101/2025.04.23.650154 — synthetic biology — Posted on 2025-04-24

1113 Conformation-specific Design: a New Benchmark and Algorithm with Application to Engineer a Constitutively Active MAP Kinase

Stern, J.; Alharbi, S.; Sandholu, A.; Arold, S. T.; Della Corte, D.

10.1101/2025.04.23.650138 — synthetic biology — Posted on 2025-04-24

1114 Harnessing Coding Sequence Cleavage: Theophylline Aptazymes as Portable Gene Regulators in Bacteria

Yurdusev, E.; Nicole, Y.; Pan Du, F.; Suslu, N. E.; Perreault, J.

10.1101/2025.04.24.650125 — synthetic biology — Posted on 2025-04-24

1115 In Vitro and Viral Evolution Convergence Reveal the Selective Pressures Driving Omicron Emergence

Shoshany, A.; Tian, R.; Blanco, M. P.; Hruska, A.; Konar, A.; Baxova, K.; Zoler, E.; Mokrejs, M.; Schreiber, G.; Zahradnik, J.

10.1101/2025.04.23.650148 — evolutionary biology — Posted on 2025-04-24

1116 A novel host-encoded protein, ETP2, plays an important role in endosymbiont division in the trypanosomatid Angomonas deanei

Maurya, A. K.; Cadena, L. R.; Ehret, G.; Nowack, E. C. M.

10.1101/2025.04.22.649992 — evolutionary biology — Posted on 2025-04-24

1117 Characterization of betacoronavirus HKU-1 and OC43 internal proteins using a prototypic coronavirus

Gunawardene, C. D.; Pandey, I.; Chatterjee, S.; Penaflor-Tellez, Y.; Odle, A.; Messyasz, A.; Rajsbaum, R.; Sariol, A.; Wong, L.-Y. R.

10.1101/2025.04.23.650176 — microbiology — Posted on 2025-04-24

1118 Activation of complement protein C3 depicts the dynamic tissue damage of the cochlea after noise trauma.

Guo, Z.; Seicol, B. J.; Shenouda, M.; Wang, A.; Garrity, K.; Lin, S.; Xie, R.

10.1101/2025.04.20.649717 — neuroscience — Posted on 2025-04-24

1119 Horizontal saccade bias results from combination of saliency anisotropies and egocentric biases

Reeves, S. M.; Otero-Millan, J.

10.1101/2025.04.21.648827 — neuroscience — Posted on 2025-04-24

1120 A whole genomic CRISPR-Cas9 screen identifies the amino acid transporter SLC43A1 (LAT3) as a major determinant of oxaliplatin sensitivity in colorectal cancer cells

Pawar, N. R.; Wade, H. M.; Jackson, Z.; Poungpeth, N.; Mitchell, A. V.; Jewell, C. P.; Chan, D.; Robey, R. W.; Batista, P. J.; Jenkins, L. M.; Gottesman, M. M.

10.1101/2025.04.21.649594 — cancer biology — Posted on 2025-04-24

1121 Tube feet dynamics drive adaptation in sea star locomotion

Deridoux, A.; Heydari, S.; Gorb, S.; Kanso, E.; Flammang, P.; Gabriele, S.

10.1101/2025.04.22.649740 — biophysics — Posted on 2025-04-24

1122 Attention-Based Solution for Synergistic Virus Combination Therapy

Majidifar, S.; Hooshmand, M.

10.1101/2025.04.22.649915 — bioinformatics — Posted on 2025-04-24

1123 Task Splitting and Prompt Engineering for Cypher Query Generation in Domain-Specific Knowledge Graphs

Soleymani, S.; Gravel, N. M.; Kochut, K.; Kannan, N.

10.1101/2025.04.23.649790 — bioinformatics — Posted on 2025-04-24

1124 Comparative analysis of genomic prediction approaches for multiple time-resolved traits in maize

Hobby, D.; Lindner, R.; Mbebi, A. J.; Tong, H.; Nikoloski, Z.

10.1101/2025.04.22.649925 — bioinformatics — Posted on 2025-04-24

1125 The essential co-chaperone Sgt1 regulates client dwell time in the Hsp90 chaperone cycle

Engler, S.; Delhommel, F.; Dodt, C.; Lopez, A.; Faust, O.; Napolitano, V.; Popowicz, G. M.; Rosenzweig, R.; Sattler, M.; Buchner, J.

10.1101/2025.04.24.648904 — biochemistry — Posted on 2025-04-24

1126 Wild raccoons are more innovative but not bolder than another ecological generalist, the Virginia opossum, on a pull-string task

Adaway, K. A.; Snider, M. H.; Vinciguerra, C.; Kupferman, C. A.; Beasley, J. C.; Morton, B.

10.1101/2025.04.21.649439 — animal behavior and cognition — Posted on 2025-04-24

1127 Amniotic fluid extracellular vesicle properties evolve with gestational age and reflect fetal development

Atukorala, I.; Beard, S.; Ang, C.-S.; Brown, H. G.; Raghavan, S.; de Alwis, N.; Fato, B.; Binder, N.; Hannan, N.; Hui, L.

10.1101/2025.04.23.649052 — developmental biology — Posted on 2025-04-24

1128 Dpp Scaling is Not the Key to Robust Wing Patterning in Drosophila

Ghag, B. A.; Shingleton, A. W.

10.1101/2025.04.22.649574 — developmental biology — Posted on 2025-04-24

1129 Characterization of iGABASnFR2 for in vivo mesoscale imaging of intracortical GABA dynamics

Rezaei, E.; Tohidi, S.; Nazari-Ahangarkolaee, M.; Karimi Abadchi, J.; Michelson, N. J.; Murphy, T. H.

10.1101/2025.04.22.649661 — neuroscience — Posted on 2025-04-24

1130 Profiling the secretome: maternal obesity impacts redox and adipogenix signaling molecules during neonatal mesenchymal stem cells' adipogenesis

Bellalta, S.; Pinheiro-Machado, E.; Prins, J.; Casanello, P.; Faas, M.; Plosch, T.

10.1101/2025.04.21.649774 — physiology — Posted on 2025-04-24

1131 Inter-Spheroid Proximity and Matrix Remodeling Determine CAF-Mediated Cancer Cell Invasion

Mehta, P. P.; Bordoloi, A. D.; Ravensbergen, C.; David, K.; Liefers, G.-J.; Mesker, W.; ten Dijke, P. P.; Boukany, P.

10.1101/2025.04.24.648914 — cancer biology — Posted on 2025-04-24

1132 Cell state transitions drive the evolution of disease progression in B-lymphoblastic leukemia

Gravenmier, C.; Marzban, S.; Tang, Y.-H.; Gillis, N.; Shah, B. D.; Moscinski, L.; Zhang, L.; West, J.

10.1101/2025.04.21.649796 — cancer biology — Posted on 2025-04-24

1133 2H MRI-based quantification of leucine uptake in glioblastoma multiforme

McClendon, S.; Ge, X.; Song, K.-H.; Grief, D.; Fortin Ensign, S. P.; Kodibagkar, V. D.; Hu, L. S.; Garbow, J. R.; Beeman, S. C.

10.1101/2025.04.23.648848 — cancer biology — Posted on 2025-04-24

1134 BioMiner: A Multi-modal System for Automated Mining of Protein-Ligand Bioactivity Data from Literature

Yan, J.; Zhu, J.; Yang, Y.; Liu, Q.; Zhang, K.; Zhang, Z.; Liu, X.; Zhang, B.; Gao, K.; Xiao, J.; Chen, E.

10.1101/2025.04.22.648951 — bioinformatics — Posted on 2025-04-24

1135 Assemblies of long-read metagenomes suffer from diverse errors

Trigodet, F.; Sachdeva, R.; Banfield, J. F.; Eren, A. M.

10.1101/2025.04.22.649783 — bioinformatics — Posted on 2025-04-24

1136 High-quality metagenome assembly from nanopore reads with nanoMDBG

Benoit, G.; James, R.; Raguideau, S.; Alabone, G.; Goodall, T.; Chikhi, R.; Quince, C.

10.1101/2025.04.22.649928 — bioinformatics — Posted on 2025-04-24

1137 Advancing Pediatric and Longitudinal DNA Methylation Studies with CellsPickMe, an Integrated Blood Cell Deconvolution Method

Fu, M. P.; Edwards, K.; Navarro-Delgado, E. I.; Merrill, S. M.; Kitaba, N. T.; Konwar, C.; Mandhane, P.; Simons, E.; Subbarao, P.; Moraes, T. J.; Holloway, J. W.; Turvey, S. E.; Kobor, M. S.

10.1101/2025.04.22.649907 — bioinformatics — Posted on 2025-04-24

1138 Chromosome-scale genome assembly of the European common cuttlefish Sepia officinalis

Rencken, S.; Tushev, G.; Hain, D.; Ciirdaeva, E.; Simakov, O.; Laurent, G.

10.1101/2025.04.22.649952 — genomics — Posted on 2025-04-24

1139 Gene turnover and contingency facilitated the repeated evolution of C4 photosynthesis in grasses

Pereira, L.; Alenazi, A. S.; Mian, S.; Leitch, I. J.; Christin, P.-A.; Osborne, C. P.; Dunning, L. T.

10.1101/2025.04.23.650007 — evolutionary biology — Posted on 2025-04-24

1140 Biased estimates of phylogenetic branch lengths resulting from the discretised Gamma model of site rate heterogeneity

Ferretti, L.; Golubchik, T.; Di Lauro, F.; Ghafari, M.; Villabona-Arenas, J.; Atkins, K. E.; Fraser, C.; Hall, M. D.

10.1101/2024.08.01.606208 — evolutionary biology — Posted on 2025-04-24

1141 A large-scale phylogeny of replication initiation proteins illuminates plasmid macroevolutionary landscape

Nishimura, Y.; Kaneko, K.; Kamijo, T.; Isogai, N.; Tokuda, M.; Xie, H.; Tsuda, Y.; Hirabayashi, A.; Moriuchi, R.; Dohra, H.; Kimbara, K.; Suzuki-Minakuchi, C.; Nojiri, H.; Suzuki, H.; Suzuki, M.; Shintani, M.

10.1101/2024.09.03.610885 — microbiology — Posted on 2025-04-24

1142 Gut-Germline Axis: A Reproductive Endosymbiont's Adaptation is Modulated by the Gut Microbiome

Imchen, M.; Kaur, R.; Luo, D. H. Z.; Bitman, M. W.; Lefoulon, E.; McGarry, A.; Bordenstein, S. R.; Bordenstein, S. R.

10.1101/2024.09.10.611936 — microbiology — Posted on 2025-04-24

1143 Stability and Adaptability in Balance: A Dual Mechanism for Metaplasticity in Cortical Networks

Tompos, T.; Zeldenrust, F.; Celikel, T.

10.1101/2025.04.02.646896 — neuroscience — Posted on 2025-04-24

1144 A universal spectrum annotator for complex peptidoforms in mass spectrometry-based proteomics

Schulte, D.; Leuvenink, R.; Jager, S.; Heck, A. J. R.; Snijder, J.

10.1101/2025.01.18.633732 — bioinformatics — Posted on 2025-04-24

1145 Bioengineering of the implantable vascularized endocrine constructs for insulin delivery suitable for clinical upscaling

Bellofatto, K.; Lebreton, F.; Hassany, M.; Hanna, R.; Bignard, J.; Marteyn, A.; Mar Fonseca, L.; Campo, F.; Olgasi, C.; Wolf-van Buerck, L.; Honarpisheh, M.; MARTINEZ DE TEJADA WEBER, B.; Follenzi, A.; Citro, A.; Piemonti, L.; THAUNAT, O.; Seissler, J.; COMPAGNON, P.; cohen, m.; BERISHVILI, E.; VANGUARD consortium,

10.1101/2025.04.19.647461 — bioengineering — Posted on 2025-04-24

1146 A highly stable engineered disulfide bond in the dimer interface of E. coli orotate phosphoribosyl transferase measures cytosolic redox conditions in yeast

Kurauskas, V.; Albrechtsen, S. P.; Gersing, S.; Johansson, K. E.; Hartmann-Petersen, R.; Willemoes, M.; Winther, J. R.

10.1101/2025.01.14.632917 — biochemistry — Posted on 2025-04-24

1147 Comparison of whole-genome assemblies of European river lamprey (Lampetra fluviatilis) and brook lamprey (Lampetra planeri)

Torresen, O. K.; Garmann-Aarhus, B.; Hoff, S. N. K.; Jentoft, S.; Svensson, M.; Schartum, E.; Tooming-Klunderud, A.; Skage, M.; Krabberod, A.; Vollestad, L. A.; Jakobsen, K. S.

10.1101/2024.12.06.627158 — genomics — Posted on 2025-04-24

1148 The Deubiquitinase USP36 Regulates Growth and Spermatogenesis Through Catalytic-Dependent and -Independent Mechanisms in Drosophila

Coirry, C.; Manessier, J.; Clot, C.; Mortier, M.; Fauvarque, M.-O.; Taillebourg, E.

10.1101/2025.03.25.644999 — genetics — Posted on 2025-04-24

1149 Dual transcranial electromagnetic stimulation of the precuneus-hippocampus network boosts human long-term memory

Borghi, I.; Mencarelli, L.; Maiella, M.; Casula, E. P.; Ferraresi, M.; Candeo, F.; Savastano, E.; Assogna, M.; Bonni, S.; Koch, G.

10.1101/2024.10.25.620008 — neuroscience — Posted on 2025-04-24

1150 INSIGHT: In Silico Drug Screening Platform using Interpretable Deep Learning Network

Shi, X.; Ramathal, C.; Dezso, Z.

10.1101/2025.04.21.649855 — bioinformatics — Posted on 2025-04-24

1151 In vivo generation of chimeric antigen receptor T cells using optimally retargeted and functionalized lentiviral vectors with reduced immune clearance

Mears, K.; Ibrahim, K.; Allen, P. M.; Chinai, J. M.; Avila, O. L.; Muscato, A. J.; Late-Reticker, S. K.; Rojas, A.; Knudson, N. H.; Chao, C.-C.; Yates, K. B.; Manguso, R. T.

10.1101/2025.04.23.645810 — bioengineering — Posted on 2025-04-24

1152 Illuminating the Unconscious: Physical and Perceived Brightness in Cognitive Processing

Martinsen, M. M.; Senda, H.; Tamura, H.; Nakauchi, S.; Minami, T.

10.1101/2025.04.20.649724 — biochemistry — Posted on 2025-04-24

1153 Navigating sampling bias in discrete phylogeographic analysis: assessing the performance of an adjusted Bayes factor

Gambaro, F.; Layan, M.; Baele, G.; Vrancken, B.; Dellicour, S.

10.1101/2025.04.23.650183 — evolutionary biology — Posted on 2025-04-24

1154 Lymphatic dissemination drives systemic invasion by diverse clinically relevant extracellular bacterial pathogens

Siggins, M. K.; Kwong Li, H.; Huse, K. K.; Pearson, M.; Openshaw, P. J.; Jackson, D. G.; Sriskandan, S.

10.1101/2025.04.21.649860 — immunology — Posted on 2025-04-24

1155 Structural insights into allosteric mechanism of glycine transporter-mediated analgesia

Cantwell Chater, R. P.; Peiser-Oliver, J.; Pati, T. K.; Quinn, A. S.; Lotsaris, I.; Frangos, Z. J.; Tischer, A. E.; Williams-Noonan, B. J.; O'Mara, M. L.; Michaelides, M.; Mohammadi, S. A.; Cioffi, C. L.; Vandenberg, R. J.; Shahsavar, A.

10.1101/2025.04.21.649698 — neuroscience — Posted on 2025-04-24

1156 BRCA2 reversion mutation-independent resistance to PARP inhibition in prostate cancer through loss of function perturbations in the DNA pre-replication complex

Pappas, K. J.; Ferrari, M.; Smith, P.; Nandakumar, S.; Khan, Z.; Young, S. B.; LaClair, J.; Russo, M. V.; Huang-Hobbs, E.; Schultz, N.; Abida, W.; Karthaus, W.; Jasin, M.; Sawyers, C.

10.1101/2025.04.20.649668 — cancer biology — Posted on 2025-04-24

1157 Chromosomal Aneuploidy in Normal, Non-Neuronal Brain Nuclei of Glioblastoma Patients is Not a Cancer Driver

Montagna, C.; Albert, O.; Sun, S.; Lin, J.-R.; Lee, M.; Chan, C.; Maslov, A. Y.; Ellerby, L.; Huttner, A.; Zhang, Z.; Vijg, J. V.

10.1101/2025.04.22.649812 — cancer biology — Posted on 2025-04-24

1158 SIMIT-seq: a bead-free, scalable microfluidic platform for single cell mRNA sequencing with ultrahigh cell-indexing rate

Duan, M.; Gao, W.; Li, G.; Cai, Y.; Zhao, Z.; Lan, X.; Wang, D.; Xing, X.; Luo, Y.

10.1101/2025.04.23.650129 — bioinformatics — Posted on 2025-04-24

1159 SCassist: An AI Based Workflow Assistant for Single-Cell Analysis

Nagarajan, V.; Shi, G.; Arunkumar, S.; Liu, C.; Gopalakrishnan, J.; Nath, P. R.; Jang, J.; Caspi, R.

10.1101/2025.04.22.650107 — bioinformatics — Posted on 2025-04-24

1160 Shiny-Calorie: A context-aware application for indirect calorimetry data analysis and visualization using R

10.1101/2025.04.24.648116 — bioinformatics — Posted on 2025-04-24

1161 SieveAI: Development of an Automated extensible and customisable drug discovery pipeline and its validation

Sahu, V. K.; Sand, A.; Ballav, S.; Raman, V.; Nagar, S.; Ranjan, A.; Basu, S.

10.1101/2025.04.20.648820 — bioinformatics — Posted on 2025-04-24

1162 Meta-AlignNN: A meta-learning framework for stable brain-computer interface performance across subjects, time, and tasks

Zou, Y.; Liu, K.; Zhang, C.; Ling, Y.; Wang, F.; Li, M.; Chen, Y.; Li, M.; Guan, S.; He, Z.; Li, C. T.

10.1101/2025.04.20.649482 — bioengineering — Posted on 2025-04-24

1163 Mesoscopic whole-brain T2*-weighted and associated quantitative MRI in healthy humans at 10.5 T

Liu, J.; Van Gelderen, P.; de Zwart, J. A.; Duyn, J. H.; Huang, Y.; Grant, A.; Auerbach, E.; Waks, M.; Lagore, R. L.; Delabarre, L.; Tarakameh, A. S.; Eryaman, Y.; Adrian, G.; Ugurbil, K.; Wu, X.

10.1101/2025.04.21.649819 — bioengineering — Posted on 2025-04-24

1164 Advancing the understanding of the Bombyx mori genome through satellite DNA analysis: low strain differentiation and relationship with transposable elements

Rico-Porras, J. M.; Mora Ruiz, P.; Palomeque, T.; Lorite, P.; Cabral-de-Mello, D. C.

10.1101/2025.04.21.649856 — genomics — Posted on 2025-04-24

1165 Experimental galactose-1 phosphate uridylyltransferase (GALT) mRNA therapy improves motor-related phenotypes in a mouse model of Classic Galactosemia

Bellagamba, O. S.; Guo, A.; Yan, X.; Sarkis, J.; Balakrishan, B.; Lai, K.

10.1101/2025.04.21.649843 — genetics — Posted on 2025-04-24

1166 Utilizing CNNs for classification and uncertainty quantification for 15 families of European fly pollinators

Stark, T.; Wurm, M.; Stefan, V.; Wolf, F.; Taubenböck, H.; Knight, T. M.

10.1101/2025.04.22.649975 — ecology — Posted on 2025-04-24

1167 Large Animal Epilepsy Model Platform: Kainic Acid Porcine Model of Mesial Temporal Lobe Epilepsy

Mivalt, F.; Maltais, D.; Kim, I.; Kim, J.; Began, P.; Duque Lopez, A.; Krakorova, V.; Winter, B.; Gregg, N. M.; Montonye, D.; Gow, C.; Miller, K. J.; Van Gompel, J.; Leyde, K.; Kremen, V.; Worrell, G. A.

10.1101/2025.01.22.634312 — neuroscience — Posted on 2025-04-24

1168 Dissociating stimulus encoding and task demands in ECoG responses from human visual cortex

Qadir, Z.; Huang, H.; Ozker, M.; Yoshor, D.; Beauchamp, M. S.; Kay, K.; Hermes, D.

10.1101/2025.04.23.648016 — neuroscience — Posted on 2025-04-24

1169 Heme-NO dilates arteries via mobilization of NO moieties from a vascular intracellular NO store

Liu, T.; Zhang, M.; Zhu, L.; Ke, H.; Souza, A. d.; Li, Q.; Castella, D.; Lehnert, N.; Zhang, L.; Blood, A. B.

10.1101/2025.04.22.650128 — physiology — Posted on 2025-04-24

1170 DeltaBreed: A BrAPI-centric breeding data information system

Yarnes, S. C.; Palladino, N.; Meidlinger, D. J.; Philips, D. R.; Sweeney, H. M.; Mustafa, S.; Mandych, M. L.; Bouabane, S.; Parsons, T. E.; Slonecki, T. J.; Zhao, D.; Rife, T. W.; Ellerbrock, B. J.; Courtney, C.; Selby, P.; Flores-Gonzalez, M.; Mueller, L. A.; Aparicio, J. S.; Al-Sham'aa, K.; Raubach, S.; Beil, C. T.; Sheehan, M. J.; Meng Lin, Edwin Reidel, Tyr Wiesner-Hanks, Arlyn J Ackerman, Alexandra M Casa, Alexander M Sandercoc,

10.1101/2025.04.23.650200 — bioinformatics — Posted on 2025-04-24

1171 Integration of parallel pathways for flight control in a hawkmoth reflects prevalence and relevance of natural visual cues

Stoeckl, A.; Bigge, R.; Grittner, R.

10.1101/2024.08.24.609346 — animal behavior and cognition — Posted on 2025-04-24

1172 Transcription-based identification of uncharacterized genes in the human immune response

Vorsteveld, E. E.; Kersten, S.; Kaffa, C.; Simons, A.; 't Hoen, P. A. C.; Netea, M. G.; Hoischen, A.

10.1101/2025.04.22.646545 — genomics — Posted on 2025-04-24

1173 The search for Lake Superior ciscoes as described by W. Koelz in 1929 yields a surprising discovery: Shortnose Cisco (Coregonus reighardi), a presumed extinct species

Gorman, O. T.; Ackiss, A. S.; Pratt, T. C.; Lyons, J. F.; Renauer-Bova, R.; Siegel, J. V.; J, R. A.; Kao, Y.-C.

10.1101/2025.04.20.649663 — evolutionary biology — Posted on 2025-04-24

1174 Close-Up of vesicular ER Exit Sites by Volume Electron Imaging using FIB-SEM

Nair, A.; Nair, A.; Stock, P.; Jain, A.; Somerville, E.; Sanyal, A.; Kirchhausen, T.

10.1101/2025.04.23.650353 — cell biology — Posted on 2025-04-24

1175 The influence of similarity, sensitivity and bias on letter identification

Barhoom, H.; Joshi, M. R.; Schmidtmann, G.

10.1101/2025.04.20.649714 — neuroscience — Posted on 2025-04-24

1176 Differential memory enrichment of cytotoxic CD4 T cells in Parkinson's disease patients reactive to α-synuclein

Freuchet, A.; Johansson, E.; Frazier, A.; Litvan, I.; Goldman, J. G.; Alcalay, R. N.; Sulzer, D.; Lindestam Arlehamn, C. S.; Sette, A.

10.1101/2025.04.21.649867 — neuroscience — Posted on 2025-04-24

1177 Behavioral deficits and exacerbated hemodynamics during lifespan of a mouse model of late onset Alzheimer's disease expressing humanized APOEϵ4 and Trem2*R47H

izydorczak, M.; Oumov, M.; Udhwani, M. V.; Fostok, F.; Coronas-Samano, G.; Sanganahalli, B. G.; Herman, P.; Hyder, F.; Verhagen, J. V.

10.1101/2025.04.20.649712 — neuroscience — Posted on 2025-04-24

1178 T cell responses towards PINK1 and α-synuclein are elevated in prodromal Parkinson's disease

Johansson, E.; Freuchet, A.; Williams, G. P.; Michealis, T.; Frazier, A.; Litvan, I.; Goldman, J. G.; Alcalay, R. N.; Standaert, D. G.; Amara, A. W.; Stover, N.; Fon, E. A.; Postuma, R. B.; Sidney, J.; Sulzer, D.; Lindestam Arlehamn, C. S.; Sette, A.

10.1101/2025.04.21.649871 — neuroscience — Posted on 2025-04-24

1179 Translatome profiling reveals opposing alterations in inhibitory and excitatory neurons of Fragile X mice and identifies EPAC2 as a therapeutic target.

Suresh, A.; Kourdougli, N.; Buth, J. E.; Sanchez-Leon, C. A.; Wall, L. T.; Tran, A. T.; Miranda-Rottmann, S.; Araya, R.; Gandal, M. J.; Portera-Cailliau, C.

10.1101/2025.04.21.649817 — neuroscience — Posted on 2025-04-24

1180 Proteomic profiling of bacterial extracellular vesicles for exploring ovarian cancer biomarkers

Asano-Inami, E.; Yokoi, A.; Yoshida, K.; Taki, K.; Kitagawa, M.; Suzuki, K.; Uekusa, R.; Nagao, Y.; Yoshikawa, N.; Niimi, K.; Yamamoto, Y.; Kajiyama, H.

10.1101/2025.04.20.649473 — cancer biology — Posted on 2025-04-24

1181 Spatial control of karyopherin binding avidity within NPC mimics revealed by designer FG-Nucleoporins

de Vries, H. W.; Barth, A.; Fragasso, A.; Otto, T. A.; van der Graaf, A.; van der Sluis, E. O.; van der Giessen, E.; Veenhoff, L. M.; Dekker, C.; Onck, P. R.

10.1101/2025.04.21.649908 — biophysics — Posted on 2025-04-24

1182 Dynamic Contrastive Learning with Pretrained Deep Language Model Enhances Metagenome Binning for Contigs

Zou, B.; Zhang, Z.; Tao, R.; Gu, N.; Zhang, L.

10.1101/2025.04.20.649691 — bioinformatics — Posted on 2025-04-24

1183 An interpretable alphabet for local protein structure search based on amino acid neighborhoods

Zerefa, S.; Cool, J.; Singh, P.; Petti, S.

10.1101/2025.04.21.649886 — bioinformatics — Posted on 2025-04-24

1184 Label-free quantification in the Crux toolkit

Acquaye, F. L. N. A.; Wen, B.; Grant, C. E.; Noble, W. S.; Kertesz-Farkas, A.

10.1101/2025.04.21.649897 — bioinformatics — Posted on 2025-04-24

1185 NewroBus for the brain: humanized TfR1-targeting nanobodies with high BBB permeability and cargo transport capacity

Yin, T.; Yesiltepe, M.; Metkar, S.; Ramon, A. E.; Greening, M.; Sormanni, P.; D'Adamio, L.

10.1101/2025.04.20.649139 — bioengineering — Posted on 2025-04-24

1186 A Continuously Oxygenated Macroencapsulation System Enables High-Density Packing and Delivery of Insulin-Secreting Cells

Pham, T. T.; Tran, P. L.; Tempelman, L. A.; Stone, S. G.; Piccirillo, C.; Li, A.; Flanders, J. A.; Ma, M.

10.1101/2025.04.21.649806 — bioengineering — Posted on 2025-04-24

1187 Systemic trafficking of mRNA lipid nanoparticle vaccine following intramuscular injection generates potent tissue-specific T cell response

Wei, C.; Zhu, Y.; Lu, X.; Goodier, K. D.; Yu, D.; Liu, X.; Choy, J.; Tellez Calderon, A.; Ma, J.; Su, Y.; Lin, J.; Li, S.; Schneck, J. P.; Murphy, S. C.; Mao, H.-Q.

10.1101/2025.04.21.649878 — bioengineering — Posted on 2025-04-24

1188 Mind the corner: Fillets in cryo-FIB lamella preparation to minimise sample loss caused by stress concentration and lamella breakage

Gorelick, S.; Velamoor, S.; Cleeve, P.; Trepout, S.; Ying, L.; Naranbhai, V.; Ramm, G.

10.1101/2025.04.21.649880 — biochemistry — Posted on 2025-04-24

1189 Genomic and Immunogenomic Profiling of Extramedullary Acute Myeloid Leukemia Reveals Actionable Clonal Branching and Frequent Immune Editing

Collignon, C.; Hansen, T.; Hercus, C.; Ruzinova, M. B.; Guepin, G. R.; Bonmati, C.; Rubio, M. T.; Feugier, P.; Gaudfrin, M.; Sartelet, H.; Divoux, M.; Muller, M.; Heath, S.; Uy, G.; Spencer, D.; Chen, D.; Pagliuca, S.; Ferraro, F.

10.1101/2025.04.18.649610 — genomics — Posted on 2025-04-24

1190 A novel transgenic reporter to study vertebrate epigenetics

Marvel, M.; Gore, A. V.; Taimatsu, K.; Castranova, D.; Margolin, G.; Goldstein, A.; Swearer, A. A.; Carpinello, O.; Combs, J.; Detels, M.; Greenspan, L. J.; Parker, A.; Kim, Y. A.; Khor, J. M.; Davis, A. E.; Kenton, M. I.; Prevedel, J.; Barnes, K.; Iben, J. R.; Li, T.; Faucz, F. R.; Dale, R.; Weinstein, B. M.

10.1101/2025.04.21.649821 — genomics — Posted on 2025-04-24

1191 Evolutionary Consequences of Unusually Large Pericentric TE-rich Regions in the Genome of a Neotropical Fig Wasp

Zhao, Z.; Quinteros, K.; Machado, C. A.

10.1101/2025.04.20.649723 — genomics — Posted on 2025-04-24

1192 Sexually Dimorphic Circadian Regulation of Eclosion and Clock Gene Expression in a Migratory Moth Spodoptera frugiperda

Lv, C.; Ren, Y.; Krylov, V. V.; Wang, Y.; Li, Y.; Pan, W.; Hu, G.; Chen, F.; Wan, G.

10.1101/2025.04.21.649798 — ecology — Posted on 2025-04-24

1193 Beige fat appearance during lipoatrophy reveals trade-offs between metabolic homeostasis and female fertility

Anaya, E. S.; Dion, W.; Saha, P.; Cox, A. R.; de Groot, E.; Ahmed, A.; Felix, J. B.; Zhu, B.; Pangas, S. A.; Hartig, S. M.

10.1101/2025.04.21.649835 — cell biology — Posted on 2025-04-24

1194 The C. elegans gustatory receptor homolog LITE-1 is a chemoreceptor required for diacetyl avoidance

Koh, A.; Bokman, E.; Gavrikov, A.; Rodriguez, J.; Chen, C.; Zaslaver, A.; Brown, A. E. X.

10.1101/2025.04.20.649642 — neuroscience — Posted on 2025-04-24

1195 FGF21 signals through KLB-expressing glutamatergic neurons in the hindbrain to mediate the effects of dietary protein restriction

Spann, R. A.; Kim, S. Q.; Khan, M. S. H.; Albarado, D. A.; Fernandez-Kim, S. O.; Berthoud, H.-R.; McDougal, D. H.; Münzberg, H.; He, Y.; Yu, S.; Morrison, C. D.

10.1101/2025.04.19.649640 — neuroscience — Posted on 2025-04-24

1196 Aperiodic neural timescales in prefrontal cortex dilate with increased task abstraction

Cellier, D.; Riddle, J.; Hammonds, R.; Frohlich, F.; Voytek, B.

10.1101/2025.04.21.649913 — neuroscience — Posted on 2025-04-24

1197 TDP-43 toxic gain of function links ALS/FTLD-TDP and Alzheimer's Disease through splicing

Van Zuiden, W.; Meimoun, T. D.; Bar, C.; Siany, A.; Moshe, L.; Yacovzada, N. S.; Weizman, E.; Neumann, M.; Buchman, A. S.; Wang, Y.; Bennett, D. A.; Glass, J. D. G. D.; Trautwig, A. N.; Seyfried, N.; Cooper-Knock, J.; Hornstein, E.

10.1101/2025.04.20.648873 — neuroscience — Posted on 2025-04-24

1198 Temporal Synchronization Analysis: A Model-Free Method for Detecting Robust and Nonlinear Brain Activation in fMRI Data

Fialoke, S.; Deb, A.; Rode, K.; Tripathi, V.; Garg, R.

10.1101/2025.04.21.649810 — neuroscience — Posted on 2025-04-24

1199 Identifying Networks within an fMRI Multivariate Searchlight Analysis

Sharma, M.; Coutanche, M. N.

10.1101/2025.04.21.649903 — neuroscience — Posted on 2025-04-24

1200 Lipid Mediated Formation of Antiparallel Aggregates in Cerebral Amyloid Angiopathy

Pacheco de Oliveira, A.; Baghel, D.; Holcombe, B.; Chase, W. E.; Ward, T.; Wang, S.-H. J.; Ghosh, A.

10.1101/2025.04.21.649887 — neuroscience — Posted on 2025-04-24

1201 Maturation of GABAergic signalling times the opening of a critical period in Drosophila melanogaster

Corke, J.; Huertas Radi, M.; Landgraf, M.; Baines, R.

10.1101/2025.04.24.650400 — neuroscience — Posted on 2025-04-24

1202 Evidence of elemental encoding at the olfactory periphery

Raps, D. A.; Pierce, G. M.; Papiani, G.; Wu, L.; Arroyave, R.; Brann, J. H.; Pfister, P.

10.1101/2025.04.21.649882 — neuroscience — Posted on 2025-04-24

1203 Plasma lipidome dysregulation in frontotemporal dementia reveals shared, genotype-specific, and severity-linked alterations

Ambaw, Y. A.; Ljubenkov, P. A.; Singh, S.; Hamed, A.; Boland, S.; Boxer, A. L.; Walther, T. C.; Farese, R.

10.1101/2025.04.20.649464 — systems biology — Posted on 2025-04-24

1204 Prevalence and risk factors of ovine and caprine fasciolosis in Ethiopia: a systematic review and meta-analysis

Endalamew, S. G.; Wassie, A. T.; Assefa, A. Y.; Ambaw, Y. G.; Ayalew, S. M.; Assefa, S. K.

10.1101/2025.04.23.650175 — scientific communication and education — Posted on 2025-04-24

1205 Convergence and constraint in glucosinolate evolution across the Brassicaceae

Agosto Ramos, A.; Bird, K.; Jain, A.; Okegbe, O.; Holland, L.; Kliebenstein, D. J.

10.1101/2025.04.23.650103 — plant biology — Posted on 2025-04-24

1206 An updated sulfate transporter phylogeny uncovers a perennial-specific subgroup associated with lignification

Surber, S. M.; Hsieh, C.; Harding, S. A. A.; Tsai, C.-J.

10.1101/2025.04.23.650276 — plant biology — Posted on 2025-04-24

1207 High resolution diel transcriptomes of autotetraploid potato reveal expression and sequence conservation among rhythmic genes

Feke, A.; Vaillancourt, B.; Acheson, K.; Brose, J.; Hamilton, J. P.; Martin, D.; Wang, Y.-W.; Wood, J. C.; Buell, C. R.; Farre, E. M.

10.1101/2025.04.22.650056 — plant biology — Posted on 2025-04-24

1208 Genomic insights and breeding strategies for nixtamalization moisture content in hybrid maize

Burns, M. J.; Berry, S. P.; Loftus, M.; Gilbert, A. M.; Hirsch, C. N.

10.1101/2025.04.23.650239 — plant biology — Posted on 2025-04-24

1209 An approach to enhance symbiotic nitrogen fixation

Gavrin, A.; Batista, M. B.; Evangelisti, E.; Dixon, R.; Schornack, S.

10.1101/2025.04.23.649995 — plant biology — Posted on 2025-04-24

1210 Prevention and reversal of hypertension-induced coronary microvascular dysfunction by a plant-based diet

Najjar, R. S.; Hekmatyar, K.; Wang, Y.; Ngo, V. L.; Lail, H.; Tejada, J. P.; Danh, J. P.; Wanders, D.; Feresin, R. G.; Mehta, P. K.; Gewirtz, A.

10.1101/2025.04.19.649660 — physiology — Posted on 2025-04-24

1211 Heat stress disrupts early development and photosymbiosis in Cassiopea jellyfish

Robinson, C.; Li, J.; Li, R.; Avila-Magana, V.

10.1101/2025.04.19.649683 — physiology — Posted on 2025-04-24

1212 Titin cleavage impairs cardiac mechanical connectivity to drive diastolic failure and fibrosis

Freundt, J. K.; Hartmann, P.; Loescher, C. M.; Unger, A.; Koser, F.; Klotz, A. J.; Wachsmuth, L.; Hille, S.; Door, M. M.; Helfen, A.; Holtmeier, R.; Faber, C.; Kirk, J. A.; Hoerr, V.; Mueller, O. J.; Linke, W. A.

10.1101/2025.04.21.649485 — physiology — Posted on 2025-04-24

1213 Peptide-functionalized fluorescent polymeric nanoparticles: polysarcosine length defines stealth properties

Gupta, T.; Bui, Q. A.; Manirakiza, H.; El Hajji, L.; Humbert, N.; Mouhamad, A. W.; Reisch, A.; Gautier, A.; Klymchenko, A. S.

10.1101/2025.04.20.649688 — pharmacology and toxicology — Posted on 2025-04-24

1214 STPath: A Generative Foundation Model for Integrating Spatial Transcriptomics and Whole Slide Images

Huang, T.; Liu, T.; Babadi, M.; Ying, R.; Jin, W.

10.1101/2025.04.19.649665 — pathology — Posted on 2025-04-24

1215 TGFb Regulated Small GTPase RHOV interact with PEAK1 and drive MYC Expression to Promote Cellular Proliferation, Migration and Etoposide resistance

Chatterjee, A.; Acharya, D.; Bhandari, N.; Bhat, P.; Chaube, B. K.; Shukla, S.

10.1101/2025.04.18.649622 — cancer biology — Posted on 2025-04-24

1216 Spatiotemporal Simulation of Radiotherapy Impact on Stage III Sigmoid Colon Cancer Using a Metabolically Coupled Agent-Based Model

Panchagnula, S. D. K.; Jonnala, P.

10.1101/2025.04.19.649627 — cancer biology — Posted on 2025-04-24

1217 ProtHGT: Heterogeneous Graph Transformers for Automated Protein Function Prediction Using Biological Knowledge Graphs and Language Models

Ulusoy, E.; Dogan, T.

10.1101/2025.04.19.649272 — bioinformatics — Posted on 2025-04-24

1218 Label-Free Live-Cell Imaging improves Mode of Action Classification

Forsgren, E.; Rietdijk, J.; Holmberg, D.; Johansson, M. M.; Carreras-Puigvert, J.; Trygg, J.; Lovell, G.; Spjuth, O.; Jonsson, P.

10.1101/2025.04.22.649936 — bioinformatics — Posted on 2025-04-24

1219 TARRAGON: Therapeutic Target Applicability Ranking and Retrieval-Augmented Generation Over Networks

Beasley, J.-M.; Schatz, K.; Ding, E.; DeLuca, M.; Abu Zaid, N.; Tucker, N.; Chirkova, R.; Crona, D.; Tropsha, A.; Muratov, E.

10.1101/2025.04.19.649662 — bioinformatics — Posted on 2025-04-24

1220 Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain

Taber, C. C.; He, W.; Gasmi-Seabrook, G. M. C.; Hubert, M.; Ferens, F. G.; Ikura, M.; Lee, J.; Ohh, M.

10.1101/2025.04.22.650142 — biochemistry — Posted on 2025-04-24

1221 Domoic acid biosynthesis and genome expansion in Nitzschia navis-varingica

Wood-Rocca, S. M.; Allsing, N.; Ashida, Y.; Mochizuki, M.; Moore, M. L.; Füssy, Z.; Kotaki, Y.; Puilingi, C.; Maeno, Y.; Beattie, A. W.; Allen, A. E.; Yotsu-Yamashita, M.; Michael, T. P.; Moore, B. S.

10.1101/2025.04.19.649686 — genomics — Posted on 2025-04-24

1222 High-density genome-wide association study points out major candidate genes for resistance to infectious pancreatic necrosis in rainbow trout

D'Ambrosio, J.; Francois, Y.; Morin, T.; Courant, S.; Desgranges, A.; Haffray, P.; Collet, B.; Boudinot, P.; Phocas, F.

10.1101/2025.04.19.649654 — genetics — Posted on 2025-04-24

1223 Local trade-offs shape flower size evolution across Arabidopsis thaliana distribution.

Sartori, K. F.; Fernandez Mestre, C.; Hossain, M. J.; Estarague, A. F.; Gaignon, E.; Lasky, J. R.; Vile, D.; Vasseur, F.; Violle, C.; Sicard, A.

10.1101/2025.04.19.649637 — evolutionary biology — Posted on 2025-04-24

1224 C. elegans SAS-1 ensures centriole integrity and ciliary function, and operates with SSNA-1

Gönczy, P.; Jha, K.; Woglar, A.; Busso, C.; Hatzopoulos, G.; Favez, T.

10.1101/2025.04.22.650004 — cell biology — Posted on 2025-04-24

1225 A pre-loaded and assembled human Ago2-miRISC orchestrates Shigella-induced vacuolar rupture through the targeting of RhoGDIα

Navarro, L.; Schiavolin, L.; Filopon, D.; Bonnet, M.; Perez-Quintero, A. L.; Charvin, M.; Sperandio, B.; Sansonetti, P. J.; TRAN VAN NHIEU, G.

10.1101/2025.04.23.650266 — molecular biology — Posted on 2025-04-24

1226 Induction of TFEB promotes Kupffer cell survival and reduces lipid accumulation and inflammation in MASLD

Chan, M. M.; Daemen, S.; Beatty, W.; Byrnes, K.; Cho, K.; Ferguson, D.; Park, A. C.; Fu, C. F.; Guo, Z.; Feldstein, N.; Park, C.; Florczak, K. L.; He, L.; Yang, B. Q.; Javaheri, A.; Patti, G.; Finck, B.; Razani, B.; Schilling, J. D.

10.1101/2025.04.19.649650 — immunology — Posted on 2025-04-24

1227 IL-18 metabolically reprograms CAR-expressing natural killer T cells and enhances their antitumor activity against neuroblastoma

Barragan, G. A.; de la Cerda, D. A.; Landoni, E.; Dholakia, K.; Humeniuk, P.; Caraballo, L. D.; Wang, Y.; Tian, G.; Yang, B.; Guo, L.; Wood, M.; Rios, X.; Xu, X.; Courtney, A. N.; Dotti, G.; Metelitsa, L. S.

10.1101/2025.04.18.649551 — immunology — Posted on 2025-04-24

1228 Pre-exposure to time-restricted feeding reduces tissue CD4+ T cells with limited effect on Mycobacterium tuberculosis clearance

Gupta, A.; Yadav, N.; Nanda, R.

10.1101/2025.04.18.649546 — immunology — Posted on 2025-04-24

1229 Single cell analysis of ovarian immune cells during homeostasis and hormonal flux reveals dynamic changes in NK and B cell populations in the periovulatory phase

Brodeur, T. Y.; Lanser, T.; Salter, L.; Sessions, K.; Hogan, T.; Bonney, E. A.; McGee, E.; Frietze, S.; Krementsov, D. N.

10.1101/2025.04.18.649580 — immunology — Posted on 2025-04-24

1230 Sleep firing rate homeostasis is disrupted in mild parkinsonism

Nandakumar, B.; Verma, A. K.; Yu, Y.; Marshall, E.; DeNicola, A.; Wang, J.; MacKinnon, C. D.; Howell, M. J.; Vitek, J. L.; Johnson, L. A.

10.1101/2025.04.18.649592 — neuroscience — Posted on 2025-04-24

1231 Hierarchical whole-brain modeling of critical synchronization dynamics in human brain

Myrov, V.; Suleimanova, A.; Knapic, S.; Liu, W.; Partanen, P.; Vesterinen, M.; Palva, S.; Palva, J. M.

10.1101/2024.05.08.593146 — neuroscience — Posted on 2025-04-24

1232 Designing Novel Solenoid Proteins with In Silico Evolution

Pretorius, D.; Nikov, G. I.; Washio, K.; Florent, S.-W.; Taunt, H.; Ovchinnikov, S.; Murray, J. W.

10.1101/2025.04.23.646631 — synthetic biology — Posted on 2025-04-24

1233 An ERF transcription factor StPTI5, a novel regulator of endophyte community maintenance in potato

Lukan, T.; Kraigher, B.; Pogacar, K.; Stare, K.; Grubar Kovacic, T.; Zagorscak, M.; Petek, M.; Stefanic, P.; Vozelj, A.; Levak, V.; Mahkovec Povalej, T.; Garcia, J. M.; Pozo, M. J.; Mandic-Mulec, I.; Gruden, K.

10.1101/2025.04.24.650297 — plant biology — Posted on 2025-04-24

1234 Spatial heterogeneity of disease infection attributable to neighbor genotypic identity in barley cultivars

Akram, I.; Rohr, L.; Shimizu, K. K.; Shimizu-Inatsugi, R.; Sato, Y.

10.1101/2025.04.22.650038 — plant biology — Posted on 2025-04-24

1235 Pseudomonas syringae pv. tomato and the fall armyworm modulate the morpho-physiology and the metabolome of potato plants

Maluleke, S.; Ogugua, U. V.; Madala, N. E.; Sibisi, P.; Mazibuko, M. P.; Nofemela, S. R.; Udeh, E. L.; Ntushelo, K.

10.1101/2025.04.23.650202 — plant biology — Posted on 2025-04-24

1236 A role of villin-dependent F-actin organization in peroxisome motility in Arabidopsis cells

Huang, C.; Koenig, A.; Lee, Y.-R. J.; Shi, Y.; Hu, J.; Liu, B.

10.1101/2025.04.23.650090 — plant biology — Posted on 2025-04-24

1237 Auto-downregulation of the florigen FT production prevents precocious flowering in plants

Tian, S.; Luo, X.; Cui, B.; He, Y.

10.1101/2025.04.24.650415 — plant biology — Posted on 2025-04-24

1238 Wave-like SnRK1 Activation and Tre6P-Sucrose Imbalance Shape Early Salt Stress Response in Growing Alfalfa Leaves

Barbieri, G.; Parola, R.; Feil, R.; Rodriguez, M. S.

10.1101/2025.04.23.650249 — plant biology — Posted on 2025-04-24

1239 Single cell omics extends metabolic regulon via orthologous transcription factors from a pair of medicinal plant species

Bui, V.-H.; Wood, J. C.; Vaillancourt, B.; Hamilton, J. P.; Jones, S. L.; Carlton, L. H.; Vu, A. H.; Buell, C. R.; Caputi, L.; Dang, T.-T. T.; Li, C.

10.1101/2025.04.22.650021 — plant biology — Posted on 2025-04-24

1240 Poplar CLE peptides stimulating ectomycorrhizal symbiosis uncovered by genome-wide identification of ectomycorrhizal-responsive small secreted peptides

Bonnot, C.; Morin, E.; Henocq, A.; Chartoire, A.; Da Silva Machado, E.; Veneault-Fourrey, C.; Kohler, A.; Martin, F. M.

10.1101/2025.04.22.649968 — plant biology — Posted on 2025-04-24

1241 Deciphering the Sequence Basis and Application of Transcriptional Initiation Regulation in Plant Genomes Through Deep Learning

Gao, P.; Lian, L.; Feng, W.; Ma, Y.; Lin, J.; Qin, L.; Hao, S.; Zhao, H.; Liu, X.; Yuan, J.; Lin, Z.; Li, X.; Guan, Y.; Wang, X.

10.1101/2025.04.22.649999 — plant biology — Posted on 2025-04-24

1242 Exploring Effective Ingredients and Potential Mechanisms of Stem Cell-derived Dendrobium Officinale Extract in Treatment of Allergic Rhinitis

ZHANG, J.; Li, J.

10.1101/2025.04.18.649518 — pharmacology and toxicology — Posted on 2025-04-24

1243 A Lipid Prodrug Strategy Enhances Targeted Protein Degrader CNS Pharmacokinetics

Leconte, G.; Gadbois, G. E.; Sepulveda, Y.; Schwarz, A.; Chang, E.; Suhandynata, R. T.; Momper, J. D.; Ferguson, F.

10.1101/2025.04.18.649560 — pharmacology and toxicology — Posted on 2025-04-24

1244 Neoantigens drive adoptively transferred CD8 T cells to long-lived effectors mediated by lymph node trafficking

Wittling, M. C.; Rivera Reyes, A. M.; Wyatt, M. M.; Smith, A. S.; Cole, A. C.; Rangel Rivera, G. O.; Ware, M. B.; Ruffin, A. T.; Kumaresan, S.; Bennett, F. J.; Lesinski, G. B.; Paulos, C. M.; Knochelmann, H. M.

10.1101/2025.04.18.649565 — cancer biology — Posted on 2025-04-24

1245 ZMS-6659, a selective Polθ helicase inhibitor, demonstrates anti-tumor activity as monotherapy and synergy effect with PARP inhibitors and topoisomerase inhibitors

jiang, l.; Li, J.; Liu, L.; Li, M.; Li, W.; Li, Z.; Qian, S.; Shi, M.; Dai, J.; Ao, C.; Qu, Y.; Li, Z.; Zhou, L.; Yang, C.; Wang, X.; Tang, R.; Zhou, F.; Liu, G.; Xue, L.

10.1101/2025.04.19.649634 — cancer biology — Posted on 2025-04-24

1246 Local collective memory from ratiometric signaling outperforms cellular gradient sensing limits

Ghose, D.; Nolen, J.; Guan, K.; Elston, T.; Lew, D. J.

10.1101/2025.04.18.649595 — biophysics — Posted on 2025-04-24

1247 One-Hot News: Drug Synergy Models Take a Shortcut

Candir, E. B.; Kuru, H. I.; Rattray, M.; Cicek, A. E.; Tastan, O.

10.1101/2025.04.18.649584 — bioinformatics — Posted on 2025-04-24

1248 Ontology-aware DNA methylation classification with a curated atlas ofhuman tissues and cell types

Kim, M.; Dannenfelser, R.; Cui, Y.; Allen, G.; Yao, V.

10.1101/2025.04.18.649618 — bioinformatics — Posted on 2025-04-24

1249 Characterization of active kinase signaling pathways in astrocytes and microglia

Ryan, W. G.; Eby, H. M.; Bearss, N. R.; Imami, A. S.; Hamoud, A.-r.; Pulvender, P.; Bollinger, J. L.; Wohleb, E. S.; McCullumsmith, R. E.

10.1101/2025.04.18.649617 — bioinformatics — Posted on 2025-04-24

1250 Norbornene homopolymerization limits cell spreading in thiol-ene photoclick hydrogels

Gentry, J. L.; Caliari, S. R.

10.1101/2025.04.18.648735 — bioengineering — Posted on 2025-04-24

1251 Neophilia in wolves and dogs

Rivas-Blanco, D.; Gonnet-dit-Revel, L.; Range, F.; Tebbich, S.; Marshall-Pescini, S.

10.1101/2025.04.24.650376 — animal behavior and cognition — Posted on 2025-04-24

1252 Cell type- and chromosome-specific chromatin landscapes and DNA replication programs of Drosophila testicular stem cells

Urban, J.; Ringwalt, D.; Urban, J.; Xue, W.; Gleason, R.; Zhao, K.; Chen, X.

10.1101/2025.04.19.649648 — genomics — Posted on 2025-04-24

1253 Systematic cell-type resolved transcriptomes of 8 tissues in 8 lab and wild-derived mouse strains captures global and local expression variation

Rebboah, E.; Weber, R.; Abdollahzadeh, E.; Swarna, N. P.; Sullivan, D. K.; Trout, D.; Reese, F.; Liang, H. Y.; Filimban, G.; Mahdipour, P.; Duffield, M.; Mojaverzargar, R.; Taghizadeh, E.; Fattahi, N.; Mojgani, N.; Zhang, H.; Loving, R. K.; Carilli, M.; Booeshaghi, A. S.; Kawauchi, S.; Hallgrimsdottir, I. B.; Williams, B. A.; MacGregor, G.; Pachter, L.; Wold, B.; Mortazavi, A.

10.1101/2025.04.21.649844 — genomics — Posted on 2025-04-24

1254 Identifiability of Phylogenetic Level-2 Networks under the Jukes-Cantor Model

Englander, A. K.; Frohn, M.; Gross, E.; Holtgrefe, N.; van Iersel, L.; Jones, M.; Sullivant, S.

10.1101/2025.04.18.649493 — evolutionary biology — Posted on 2025-04-24

1255 Soil heterogeneity and pleiotropy contribute to polygenic soil adaptation during postglacial range expansion in an alpine plant

Lipanova, V.; Griepentrog, M.; Reutimann, O.; Kussmann, J.; Luqman, H.; Dötterl, S.; Fior, S.; Widmer, A.

10.1101/2025.04.20.649708 — evolutionary biology — Posted on 2025-04-24

1256 Multispecies coexistence emerges from pairwise exclusions in communities with competitive hierarchy

Miller, Z. R.; Max, D.

10.1101/2025.04.22.649899 — ecology — Posted on 2025-04-24

1257 Midbrain organoids with an SNCA gene triplication display dopamine-dependent alterations in network activity

Deyab, G.; Thomas, R. A.; Ding, X. E.; Li, J.; Sirois, J.; Al Azzawi, Z.; Niu, S.; Durcan, T.; Fon, E. A.

10.1101/2025.04.23.650231 — neuroscience — Posted on 2025-04-24

1258 Neural oscillatory dynamics in joint action: distinct contributions of entrainment and beta modulation to self/other integration

Rosso, M.; van Kerrebroeck, B.; Keller, P. E.; Leman, M.; Maes, P.-J.; Vuust, P.

10.1101/2025.04.23.650255 — neuroscience — Posted on 2025-04-24

1259 Iron deposition and functional connectivity alterations in the right substantia nigra of adult males with autism

Itahashi, T.; Tanji, K.; Shikauchi, Y.; Naoe, T.; Okimura, T.; Nakamura, M.; Ohta, H.; Hashimoto, R.-i.

10.1101/2025.04.18.649491 — neuroscience — Posted on 2025-04-24

1260 Neuronal Hyperexcitability: A Key to Unravelling Hippocampal Synaptic Dysfunctions in Lafora Disease

Costa, C.; Bellingacci, L.; Canonichesi, J.; Imperatore, V.; Taddei, A. A.; Zafra-Puerta, L.; Iglesias-Cabeza, N.; Prontera, P.; Mancini, A.; Di Filippo, M.; Tozzi, A.; Barzasi, M.; Gardoni, F.; Sanchez, M. P.; Serratosa, J. M.; Parnetti, L.; Sciaccaluga, M.

10.1101/2025.04.23.650182 — neuroscience — Posted on 2025-04-24

1261 Cognitive Graphs of Latent Structure in Rostral Anterior Cingulate Cortex

Manakov, M.; Proskurin, M.; Wang, H.; Kuleshova, E.; Lustig, A.; Behnam, R.; Druckmann, S.; Tervo, D. G. R.; Karpova, A.

10.1101/2025.04.18.649507 — neuroscience — Posted on 2025-04-24

1262 Circulating tumor cells shed shearosome extracellular vesicles in capillary bifurcations that activate endothelial and immune cells

Vrynas, A.; Bazban-Shotorbani, S.; Arfan, S.; Satia, K.; Cunningham, B.; Sagindykova, G.; Ashna, M.; Zhang, A.; Visan, D.; Chen, A.; Carter, M.; Matthews-Palmer, T.; Blackhall, F.; Simpson, K.; Dive, C.; Huang, P. H.; Au, S. H.

10.1101/2024.04.17.589880 — cancer biology — Posted on 2025-04-24

1263 Refining sperm quality assessment by high-throughput nuclear morphometric analysis

Mandawala, A. A.; Perry, J. C.; Skinner, B. M.; Walling, G. A.; Harvey, S. C.; Harvey, K. E.

10.1101/314708 — developmental biology — Posted on 2025-04-24

1264 Integrated tumour-immune cell response modelling of Luminal A breast cancer details malignant signalling and ST3Gal1 inhibitor induced reversal

Kaya, H. E.; Naidoo, K. J.

10.1101/2025.04.03.647001 — systems biology — Posted on 2025-04-24

1265 Evolutionary dynamics of FoxQ2 transcription factors across metazoans: A tale of three ancient paralogs

Gattoni, G.; Lin, C.-Y.; York, J. R.; Keitley, D.; LaBonne, C.; Yu, J.-K.; Gillis, A.; Benito-Gutierrez, E.

10.1101/2025.04.23.650082 — evolutionary biology — Posted on 2025-04-24

1266 Emergence of coordinated cell division during the evolution of multicellularity

Cedeno Perez, L. F.; Pineau, R.; Day, T. C.; Ratcliff, W. C.; Conlin, P. L.

10.1101/2025.04.23.650085 — evolutionary biology — Posted on 2025-04-24

1267 DAR1: A Flexible Framework for Ecosystem Model Exploration

Duckworth, B.; Dutkiewicz, S.; Jahn, O.; Hill, C. N.; Follett, C. L.

10.1101/2023.11.23.568480 — ecology — Posted on 2025-04-24

1268 Absence of a prolonged macrophage and B cell response inhibits heart regeneration in the Mexican cavefish

Sengul, E.; Potts, H. G.; Stockdale, W. T.; Carter, R. D.; Bevan, L.; Nozdrina, M.; Alonaizan, R.; Hu, Z.; Goodship, A.; Ying, J.; Lekkos, K.; O Byrne, L.; Lemieux, M. E.; Richardson, R.; Mommersteeg, M. T. M.

10.1101/2025.04.24.650152 — developmental biology — Posted on 2025-04-24

1269 Atomic resolution structures of the methane-activating enzyme in anaerobic methanotrophy reveal extensive post-translational modifications.

Müller, M.-C.; Wissink, M.; Mukherjee, P.; Von Possel, N.; Laso-Perez, R.; Engilberge, S.; Carpentier, P.; Kahnt, J.; Wegener, G.; Welte, C.; Wagner, T.

10.1101/2025.01.10.632498 — microbiology — Posted on 2025-04-24

1270 Segregation, Finite Time Elastic Singularities and Coarsening in Renewable Active Matter

Roychowdhury, A.; Dasgupta, S.; Rao, M.

10.1101/2024.09.05.611571 — biophysics — Posted on 2025-04-24

1271 Benchmarking cellular segmentation methods against Cellpose

Stringer, C.; Pachitariu, M.

10.1101/2024.04.06.587952 — bioinformatics — Posted on 2025-04-24

1272 Optimizing drug synergy prediction through categorical embeddings in Deep Neural Networks

Gonzalez Lastre, M.; Gonzalez de Prado Salas, P.; Guantes, R.

10.1101/2024.06.12.598611 — bioinformatics — Posted on 2025-04-24

1273 Tracking butterfly flight in the field from an unmanned aerial vehicle (UAV): a methodological proof of principle.

de Margerie, E.; Monmasson, K.

10.1101/2024.07.17.603869 — animal behavior and cognition — Posted on 2025-04-24

1274 Evaluating a Standard Benchmark for Gene Prioritization: The InheriNext(R) Algorithm's Integration of Genomic and Phenotypic Information

Chang, J.-Y.; Li, K.-T.; Kubal, M.; Tsai, Y.-S.; Hamby, A. M.; Thomson, N.; Sheridan, J.; Barfield, S.; Rutz, R.; Ong, F. S.; Feliciano, R.; Kahn, S.; Wu, S.-M.

10.1101/2025.02.25.640147 — genomics — Posted on 2025-04-24

1275 Inferring context-specific site variation with evotuned protein language models

Lytras, S.; Strange, A.; Ito, J.; Sato, K.

10.1101/2025.02.19.639211 — evolutionary biology — Posted on 2025-04-24

1276 GLOWORM-META: Modelling gastrointestinal nematode metapopulation dynamics to inform cattle biosecurity research

Ingle, O. K.; Melville, L.; Beechener, S.; Hardy, C.; Howell, A.; Hobbs, N. P.; Mahon, N.; Morgan, E. R.; Bartley, D.; Rose Vineer, H.

10.1101/2025.02.21.639461 — ecology — Posted on 2025-04-24

1277 PRDM16 functions as a co-repressor in the BMP pathway to suppress neural stem cell proliferation

He, L.; Wen, J.; Dai, Q.

10.1101/2023.01.13.523917 — developmental biology — Posted on 2025-04-24

1278 Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features

Shayler, D. W. H.; Stachelek, K.; Cambier, L.; Lee, S.; Bai, J.; Bhat, B.; Reid, M. W.; Weisenberger, D. J.; Aparicio, J. G.; Kim, Y.; Singh, M.; Bay, M.; Thornton, M. E.; Doyle, E. K.; Fouladian, Z.; Erberich, S. G.; Grubbs, B. H.; Bonaguidi, M. A.; Craft, C. M.; Singh, H. P.; Cobrinik, D.

10.1101/2023.02.28.530247 — developmental biology — Posted on 2025-04-24

1279 Mesenchymal Stromal Cells regulate human Hematopoietic Stem Cell survival, engraftment and regeneration via PGE2/cAMP signaling pathway

MUDDINENI, S. S. N. A.; Katz-Even, C.; Zipin-Roitman, A.; Rasoulouniriana, D.; Roy, D. S.; Aborgies, R.; Weizman, E.; Beider, K.; Chen, R.; Hershkovitz, G.; Shulman, Y.; Solomon, N.; Raz, Y.; Waskow, C.; Nagler, A.; Milyavsky, M.

10.1101/2023.11.09.566361 — cell biology — Posted on 2025-04-24

1280 Wnt10b signaling regulates replication stress-induced chromosomal instability in human cancer

Haas, A.; Wenz, F.; Wesslowski, J.; Davidson, G.; Voloshanenko, O.; Boutros, M.; Perez Acebron, S.; Bastians, H.

10.1101/2025.04.23.650265 — cell biology — Posted on 2025-04-24

1281 Contributions of β-lactamase substrate specificity and outer membrane permeability to the antibiotic sheltering of β-lactam-susceptible bacteria

Mora Ochomogo, M.; Jeffs, M.; Liu, J. L.; Lohans, C. T.

10.1101/2025.04.22.649001 — microbiology — Posted on 2025-04-24

1282 Aspergillus dsRNA virus drives fungal fitness and pathogenicity in the mammalian host

Rocha, M.; Lerer, V.; Adeoye, J.; Hayby, H.; Fabre, M. L.; Barber, A. E.; Shlezinger, N.

10.1101/2024.02.16.580674 — microbiology — Posted on 2025-04-24

1283 Activation dynamics and assembly of root zone soil bacterial communities in response to stress-associated phytohormones

Bandopadhyay, S.; Bagchi, O.; Shade, A.

10.1101/2025.04.23.650272 — microbiology — Posted on 2025-04-24

1284 Ultrastructural features of bacterial calcite unveil ubiquitous organics occlusion and clues on biomineralization

Grosso Giordano, F.; Purino, M.; Boon, N.; De Belie, N.; Rodriguez-Navarro, C.

10.1101/2025.04.15.648918 — microbiology — Posted on 2025-04-24

1285 3D directional tuning in the orofacial sensorimotor cortex during natural feeding and drinking

Hosack, V. B.; Arce-McShane, F. I.

10.1101/2024.07.02.601741 — neuroscience — Posted on 2025-04-24

1286 Establishing synthetic ribbon-type active zones in a heterologous expression system

Kapoor, R.; Do, T. T.; Schwenzer, N.; Petrovic, A.; Dresbach, T.; Lehnart, S.; Fernandez-Busnadiego, R.; Moser, T.

10.1101/2024.03.18.585517 — neuroscience — Posted on 2025-04-24

1287 Aberrant pace of cortical neuron development in brain organoids from patients with 22q11.2 deletion syndrome-associated schizophrenia

Sneha, R. B.; Brundu, F.; Chen, Y.; Sun, Y.; Zhu, H.; Shprintzen, R. J.; Tomer, R.; Rabadan, R.; Leong, K. W.; Markx, S.; Xu, B.; Gogos, J. A.; Kushner, S. A.

10.1101/2023.10.04.557612 — neuroscience — Posted on 2025-04-24

1288 Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer's disease

Xiao, Y.; Spotorno, N.; An, L.; Bazinet, V.; Hansen, J. Y.; Strandberg, O.; Shafiei, G.; Bejhat, H. H.; Funck, T.; Salvado, G.; Stomrud, E.; Smith, R.; Palmqvist, S.; Ossenkoppele, R.; Mattsson-Carlgren, N.; Palomero-Gallagher, N.; Dagher, A.; Misic, B.; Hansson, O.; Vogel, J. W.

10.1101/2025.04.17.648358 — neuroscience — Posted on 2025-04-24

1289 Stimulus-specificity of surround-induced responses in primary visual cortex

Cuevas, N.; Sotomayor-Gomez, B.; Tzanou, A.; Onorato, I.; Rummell, B.; Uran, C.; Broggini, A.; Vinck, M.

10.1101/2024.06.03.597080 — neuroscience — Posted on 2025-04-24

1290 Electroencephalography signals in a female Fragile X Syndrome mouse model

Ahmed, A.; Rasheva, V.; Bae, M.; Murari, K.; Cheng, N.

10.1101/2024.04.04.588163 — neuroscience — Posted on 2025-04-24

1291 Online reinforcement learning of state representation in recurrent network: the power of random feedback and biological constraints

Tsurumi, T.; Kato, A.; Kumar, A.; Morita, K.

10.1101/2024.08.22.609100 — neuroscience — Posted on 2025-04-24

1292 Dynamic Multiday Seizure Cycles in a Tetanus Toxin Rat Model of Epilepsy: Evolving Rhythms and Implications for Prediction

Zarei Eskikand, P.; Cook, M. J.; Burkitt, A. N.; Grayden, D. B.

10.1101/2024.10.15.618613 — neuroscience — Posted on 2025-04-24

1293 Cycles in Seizure Duration and Their Underlying Dynamics in the Tetanus Toxin Rat Model

Zarei Eskikand, P.; Kazemi, S.; Cook, M.; Burkitt, A. N.; Grayden, D. B.

10.1101/2024.11.27.625789 — neuroscience — Posted on 2025-04-24

1294 The Energetic Stress Marker GDF15 is Induced by Acute Psychosocial Stress

Huang, Q.; Monzel, A. S.; Rausser, S.; Haahr, R.; Bobba-Alves, N.; Devine, J.; Liu, C. C.; Kelly, C.; Thompson, E.; Kurade, M. S.; Michelson, J.; Li, S.; Engelstad, K.; Tanji, K.; Lauriola, V.; Wang, T.; Wang, S.; Marsland, A. L.; Kaufman, B. A.; St-Onge, M.-P.; Sloan, R.; Juster, R.-P.; Gouspillou, G.; Hirano, M.; Picard, M.; Trumpff, C.

10.1101/2024.04.19.590241 — physiology — Posted on 2025-04-24

1295 From climate warming to accelerated cellular ageing: an experimental study in a wild passerine bird

STIER, A.; Hsu, B.-Y.; Cossin-Sevrin, N.; Garcin, N.; Ruuskanen, S.

10.1101/2021.12.21.473625 — physiology — Posted on 2025-04-24

1296 Inferring the cell type-specific functional roles of nucleic acid-binding proteins using deep learning on co-expression networks

Osato, N.

10.1101/2025.03.03.641203 — bioinformatics — Posted on 2025-04-24

1297 Biophysics-based protein language models for protein engineering

Gelman, S.; Johnson, B.; Freschlin, C.; Sharma, A.; D'Costa, S.; Peters, J.; Gitter, A.; Romero, P. A.

10.1101/2024.03.15.585128 — bioinformatics — Posted on 2025-04-24

1298 MutBERT: Probabilistic Genome Representation Improves Genomics Foundation Models

Long, W.; Su, H.; Xiong, J.; Zhang, Y.

10.1101/2025.01.23.634452 — bioinformatics — Posted on 2025-04-24

1299 Crowdsourced Protein Design: Lessons From the Adaptyv EGFR Binder Competition

Cotet, T.-S.; Krawczuk, I.; Stocco, F.; Ferruz, N.; Gitter, A.; Kurumida, Y.; Machado, L. d. A.; Paesani, F.; Calia, C. N.; Challacombe, C. A.; Haas, N.; Qamar, A.; Correia, B. E.; Pacesa, M.; Nickel, L.; Subr, K.; Castorina, L. V.; Campbell, M. J.; Ferragu, C.; Kidger, P.; Hallee, L.; Wood, C. W.; Stam, M. J.; Kluonis, T.; Unal, S. M.; Belot, E.; Naka, A.; Adaptyv Competition Organizers,

10.1101/2025.04.17.648362 — bioengineering — Posted on 2025-04-24

1300 The gut contractile organoid: a novel model for studying the gut motility regulated by coordinating signals between interstitial cells of Cajal and smooth muscles

Yagasaki, R.; Nakamura, R.; Shikaya, Y.; Tadokoro, R.; Hao, R.; Wang, Z.; Eiraku, M.; Inaba, M.; Takahashi, Y.

10.1101/2024.03.12.584544 — developmental biology — Posted on 2025-04-24

1301 Detection of bacteria through taste receptors primes the cellular immune response

Mazariegos, A. N.; Maniere, G.; Sillon, L.; Milleville, R.; Berthelot-Grosjean, M.; Aruci, E.; Camp, D.; Alves, G.; Khaul, R.; Duval, C. J.; Chauvel, I.; Royet, J.; Grosjean, Y.; Musso, P.-y.; Tanentzapf, G.

10.1101/2024.09.26.615243 — immunology — Posted on 2025-04-24

1302 The Neural Underpinnings of Aphantasia: A Case Study of Identical Twins

Megla, E.; Prasad, D.; Bainbridge, W. A.

10.1101/2024.09.23.614521 — neuroscience — Posted on 2025-04-24

1303 Individual differences in sequential decision-making

Abbaszadeh, M.; Ozanick, E.; Magen, N.; Darrow, D. P.; Yan, X.; Grissom, N.; Herman, A.; Ebitz, B.

10.1101/2025.04.04.647306 — neuroscience — Posted on 2025-04-24

1304 Sialoglycoconjugate Profiling of Human Choroid, Retinal Pigment Epithelium, and Macular Degeneration Related Lesions

Navratil, E. M.; Wenzel, P. A.; Flamme-Wiese, M. J.; Miller, J. E. B.; Wiley, L. A.; Stone, E. M.; Tucker, B. A.; Mullins, R. F.

10.1101/2025.04.23.650306 — cell biology — Posted on 2025-04-23

1305 Hyperosmotic Stress of HL-60/S4 Cells: Gene Set Enrichment Analysis and Microscopy Changes

Olins, A. L.; Mark Welch, D. B.; Prudovsky, I.; Olins, D. E.

10.1101/2025.04.22.649232 — cell biology — Posted on 2025-04-23

1306 Treacle and MDC1 coordinate rDNA break repair by homologous recombination

Haenel, A.; Leyrer, J.; Stucki, M.

10.1101/2025.04.21.649841 — cell biology — Posted on 2025-04-23

1307 Salmonella SteD and mammalian SUSD6 use TMEM127 to co-disinhibit the WWP2 E3 ubiquitin ligase

Blundell, S. V.; Liu, M.; Tocci, R.; Majstorovic, A.; Tsang, S.; Holden, D. W.

10.1101/2025.04.23.650309 — cell biology — Posted on 2025-04-23

1308 Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins

Carloni, R.; Devlin, T.; Tong, P.; Auchynnikava, T.; Spanos, C. R.; Rappsilber, J.; Matthews, K. R.; Allshire, R. C.

10.1101/2025.04.22.649942 — cell biology — Posted on 2025-04-23

1309 The regulation of Protein Phosphatase 4 by FBXO42 is required for cancer cell survival.

Spangenberg, S. H.; Garaffo, N.; Alcindor, E. M. C.; Lusk, B.; Pandey, V.; Longhurst, A.; Bolech, E.; Fu, B. X. H.; Gilbert, L. A.; Wohlschlegel, J. A.; Toczyski, D. P.

10.1101/2025.04.22.649889 — cell biology — Posted on 2025-04-23

1310 Hierarchical cross-entropy loss improves atlas-scale single-cell annotation models

Cultrera di Montesano, S.; D'Ascenzo, D.; Raghavan, S.; Amini, A. P.; Winter, P.; Crawford, L.

10.1101/2025.04.23.650210 — cell biology — Posted on 2025-04-23

1311 A Comprehensive Workflow for Imaging Live Insulin Secretion Events and Granules in Intact Islets

Fye, M. A.; Sharma, R.; Myat, P. S. M.; Regan, P.; McKinney, H.; Gu, G.; Kaverina, I.

10.1101/2025.04.22.650066 — cell biology — Posted on 2025-04-23

1312 Parallel CRISPR screens reveal pathways controlling the cell surface levels of the attractant receptor FPR1

Akdogan, E.; Lundgren, S. M.; Kamber, R. A.; Bassik, M. C.; Collins, S. R.

10.1101/2025.04.21.649864 — cell biology — Posted on 2025-04-23

1313 Curvature-dependent morphological reorganization of the endoplasmic reticulum determines the mode of epithelial migration

Rawal, S.; Keshavanarayana, P.; Manoj, D.; Khuntia, P.; Banerjee, S.; Thurakkal, B.; Marwaha, R.; Spill, F.; Das, T.

10.1101/2025.04.22.650137 — cell biology — Posted on 2025-04-23

1314 A Novel No-Wash (Homogenous) High-Throughput Toxicity Assay on Primary Cells

Cheng, Y.; Yang, V.; Zhu, Z.; Yang, G.; Lu, J.

10.1101/2025.04.21.649658 — cell biology — Posted on 2025-04-23

1315 Characterization of a COQ8A-ataxia mouse model with E548K single-site mutation: distinct and comparable findings relative to a loss-of-function mutation

Goncalves, D.; Broyer, N.; Carret Pierrat, M.; Sarzi Campillo, E.; Reutenauer, L.; Puccio, H.

10.1101/2025.04.23.650169 — cell biology — Posted on 2025-04-23

1316 Efficiency and localisation of AURKA degradation by PROTACs is modulated by deubiquitinases UCHL5 and target-selective OTUD6A

Cardno, A.; Roberts, K.; Lindon, C.

10.1101/2025.04.23.650020 — cell biology — Posted on 2025-04-23

1317 Oncogenic mutations disrupt lineage differentiation via epigenetic perturbations

Meng, L.; Plevritis, S. K.; Yu, A.; Meng, J.; Yoo, Y.; Janas, J.; Knowles, D. A.; Huang, H.; Schaukowitch, K. M.

10.1101/2025.04.22.649974 — cell biology — Posted on 2025-04-23

1318 Stress tolerance of multiple Salmonella enterica strains associated with foodborne outbreaks

Martin, A.; Patch, C.; Vanarsdall, V. A.; Pham, R.; Whitney, G.; Markus, S.; Lunna, A.; Etter, A. J.

10.1101/2025.04.23.649775 — microbiology — Posted on 2025-04-24

1319 Tsbrowse: an interactive browser for Ancestral Recombination Graphs

Karthikeyan, S.; Jeffery, B.; Mbuli-Robertson, D.; Kelleher, J.

10.1101/2025.04.23.649987 — genomics — Posted on 2025-04-23

1320 Ploidy and neuron size impact nervous system development and function in Xenopus

Liu, X.; Wan, C.; Shah, S. A.; Heald, R.

10.1101/2025.04.22.650131 — cell biology — Posted on 2025-04-23

1321 CTHRC1 is a new therapeutic target and serum diagnostic biomarker for aortic dissection

Chen, J.; Ji, L.; Lu, J.; Zhou, J.; Wang, C.; Tian, W.; Wang, X.

10.1101/2025.04.19.649636 — cell biology — Posted on 2025-04-23

1322 Wnt10b signaling regulates replication stress-induced chromosomal instability in human cancer

Bastians, H.; Haas, A.; Wenz, F.; Wesslowski, J.; Davidson, G.; Voloshanenko, O.; Boutros, M.; Perez Acebron, S.

10.1101/2025.04.23.650265 — cell biology — Posted on 2025-04-23

1323 An evolutionarily conserved laterally acquired toolkit enables microbiota targeting by Trichomonas

Hart, A. J.; Mpeyako, L.; Bailey, N. P.; Merces, G.; Gray, J.; Biboy, J.; Banzhaf, M.; Vollmer, W.; Hirt, R. P.

10.1101/2025.04.21.649813 — molecular biology — Posted on 2025-04-23

1324 The genetic driver of Acute Necrotizing Encephalopathy, RANBP2, regulates the inflammatory response to Influenza A virus infection

Desgraupes, S.; Perrin, S.; Gouy, B.; Decorsiere, A.; Wang, Y. E.; Palazzo, A. F.; Munier, S.; Arhel, N. J.

10.1101/2025.03.23.644734 — immunology — Posted on 2025-04-23

1325 Differential effects of neurodegenerative disorders on verbal creative idea generation and its cognitive cornerstones

Chan, M. M. Y.; O'Sullivan, J. D.; Adam, R.; Mosley, P. E.; Breakspear, M.; Robinson, G. A.

10.1101/2025.04.22.650134 — neuroscience — Posted on 2025-04-23

1326 Neuroanatomy Reflects Individual Variability In Impulsivity in Youth

Dhamala, E.; Christensen, E.; Hanson, J. L.; Ricard, J. A.; Arcaro, N.; Bhola, S.; Wiersch, L.; Brosch, K.; Yeo, B. T. T.; Holmes, A.; Yip, S.

10.1101/2025.04.23.650222 — neuroscience — Posted on 2025-04-23

1327 Developmental dynamics and axonal transport of cerebral cortex projection neuron mRNAs in vivo

Veeraraghavan, P.; Tillman, D. E.; Ross, M. I.; Macklis, J. D.

10.1101/2025.04.23.650263 — neuroscience — Posted on 2025-04-23

1328 PACS1 syndrome variant alters proteomic landscape of developing cortical organoids

Gomez Maqueo Bribiesca, X.; Rylaarsdam, L.; Woo, A.; Schroder, A. L.; Rakotomamonjy, J.; Ruiz, S.; Gilardi, J.; Klei, L.; Devlin, B.; MacDonald, M. L.; Guemez-Gamboa, A.

10.1101/2025.04.23.650290 — neuroscience — Posted on 2025-04-23

1329 Linking Oestradiol (E2) Timing and Tempo, Brain Development, and Mental Health in Adolescent Females

Khetan, M.; Vijayakumar, N.; Tian, Y. E.; Whittle, S.

10.1101/2025.04.23.650187 — neuroscience — Posted on 2025-04-23

1330 SYNAPTIC INTERACTIONS IN PRIMATE MOTOR CORTEX: RELATIONS BETWEEN CONNECTIVITY AND INTRACORTICAL LOCATION

Matsumura, M.; Chen, D.-f.; Fetz, E. E.

10.1101/2025.04.22.650058 — neuroscience — Posted on 2025-04-23

1331 Ubiquitous systems drift in the evolution of development

van der Jagt, P. L.; Oud, S.; Vroomans, R. M. A.

10.1101/2025.04.23.650280 — systems biology — Posted on 2025-04-23

1332 Non-DNA-damaging DNA-PK activation improving hearing and prolonging life due to NAD+ and SIRT upregulation

Honkura, Y.; Suzuki, T.; Kujirai, R.; Kanno, S.; Matsumoto, Y.; Tanaka, Y.; Kowit, H.; Nagatoishi, S.; Tyshkovskiy, A.; Kasahara, T.; Tongu, Y.; Bohan, Z.; Kashiwagi, H.; Saegusa, C.; Fujioka, M.; Usami, R.; Chikuma, S.; Tokifuji, Y.; Matsuhashi, T.; Oikawa, Y.; Komatsu, H.; Murayama, K.; Sugasawa, T.; Nanto-Hara, F.; Taguchi, K.; Saigusa, D.; Suzuki, C.; Sato, T.; Suzuki, J.; Owada, Y.; Niizuma, K.; Endo, H.; Hashimoto, K.; Toyohara, T.; Tsumoto, K.; Anderson, P.; Gladyshev, V. N.; Hayashi, K.-i.; Katori, Y.; Tomioka, Y.; Abe, T.

10.1101/2025.04.18.649305 — cell biology — Posted on 2025-04-23

1333 Editing of the polyubiquitin architecture on the collided ribosome maintains persistent RQC activity

Tomomatsu, S.; Matsuo, Y.; Ohtake, F.; Tomita, T.; Saeki, Y.; Inada, T.

10.1101/2025.04.23.650188 — molecular biology — Posted on 2025-04-23

1334 Investigating Factors Driving Shifts in Subtype Dominance within H5Nx Clade 2.3.4.4b High-Pathogenicity Avian Influenza viruses

Billington, E.; Di Genova, C.; Warren, C. J.; Thomas, S. S.; Johnson, S.; Riccio, S.; Temperton, N. J.; da Costa, K.; Byrne, A. M. P.; Airey, M.; Schlachter, A.-L.; Yang, J.; Nunez, A.; Iqbal, M.; Slomka, M. J.; Brown, I. H.; Banyard, A. C.; James, J.

10.1101/2025.04.23.650244 — microbiology — Posted on 2025-04-23

1335 STING agonists drive recruitment and intrinsic type I interferon responses in monocytic lineage cells for optimal anti-tumor immunity

Girard, M.; Yu, T.; Batista, N. V.; Yeung, K. K.; Lamorte, S.; Gao, W.; Liu, M.; McGaha, T. L.; Watts, T. H.

10.1101/2024.12.08.627385 — immunology — Posted on 2025-04-23

1336 3D spatial transcriptomics reveals the molecular structure of input and output pathways in the mouse olfactory bulb

Klimpert, N.; Kollo, M.; Brann, D. H.; Tan, C.; Barry, D.; Ma, Y.; Schaefer, A. T.; Fleischmann, A.

10.1101/2025.02.19.639192 — neuroscience — Posted on 2025-04-23

1337 Cell cycle follows pause and play mechanism in environment stress recovery in diverse plant species

Hazelwood, O. S.; Diehl, K. A.; Hollenbeck, V.; Herb, D.; Gallagher, J. P.; Ashraf, A.

10.1101/2025.04.02.646900 — plant biology — Posted on 2025-04-23

1338 Drosophila SA1 expression prevents brain tumorigenesis and PARP-mediated cell elimination

Totaro, S.; Lettieri, A.; Castiglioni, S.; Lavezzari, F.; Gervasini, C.; Massa, V.; vaccari, t.

10.1101/2025.04.18.649500 — cancer biology — Posted on 2025-04-23

1339 Learning tissue representation by identification of persistent local patterns in spatial omics data

Tanevski, J.; Vulliard, L.; Ibarra-Arrelano, M. A.; Schapiro, D.; Hartmann, F.; Saez-Rodriguez, J.

10.1101/2024.03.06.583691 — bioinformatics — Posted on 2025-04-23

1340 A comprehensive pipeline for genome annotation across species: a case study on Schmidtea mediterranea

Zaremba, A.; Marszalek-Zenczak, M.; Dutta, A.; Samelak-Czajka, A.; Jackowiak, P.

10.1101/2025.04.16.649076 — bioinformatics — Posted on 2025-04-23

1341 CRISPR/Cas9-mediated mutagenesis of the white-eye gene in the tephritid pest Bactrocera zonata

Nazarov, A.; Partosh, T.; krsticevic, f.; Rallis, D.; arien, y.; Ostrovsky, G.; Kramer, R. M.; Halon, E.; Handler, A.; Baxter, S.; Gazit, Y.; Mathiopoulos, K.; Pines, G.; Papathanos, P. A.

10.1101/2025.04.22.650062 — bioengineering — Posted on 2025-04-23

1342 HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis

Ikeda, T.; Hong, S.; Yoshida, S.; Kunamneni, A.; Srivastava, S. P.; Yao, Y.; Basrur, V.; Kuang, H.; Kachman, M.; Baum, H.; Joshi, A.; Swaroop, V.; Thurman, A.; Kopasz-Gemmen, O.; Kandukuri, S.; Khuperkar, O.; Pradeepa, F.; Yonekura, H.; Lin, J. D.; Inoki, K.

10.1101/2025.04.22.650033 — biochemistry — Posted on 2025-04-23

1343 Optimised genome editing for precise DNA insertion and substitution using Prime Editors in zebrafish

Ono, Y.; Peterka, M.; Love, M.; Bhandari, A.; Gordon, E.; Ball, J. S.; Tyler, C. R.; Rees, S.; Bohlooly-Y, M.; Maresca, M.; Scholpp, S.

10.1101/2025.04.23.650248 — molecular biology — Posted on 2025-04-23

1344 How does Mycoplasma pneumoniae steal lipids from its host membranes?

Manger, S.; Arghittu, S. M.; Sprankel, L.; Meier-Credo, J.; Wieland, K.; Bublak, D.; Langer, J.; Covino, R.; Frangakis, A. S.

10.1101/2023.10.24.563710 — molecular biology — Posted on 2025-04-23

1345 United States PRRSV 1-4-4 L1C.5 isolate demonstrates similar pathogenicity to a historic Chinese highly pathogenic PRRSV

Wiarda, J. E.; Anderson, S. J.; Kim, H.; Chang, T.; Tidgren Hanson, L.; Zanella, E. L.; Arruda, B.; Wymore Brand, M.; Hau, S. J.; Zhang, J.; Buckley, A. C.

10.1101/2025.04.23.648216 — microbiology — Posted on 2025-04-23

1346 Structural Dissection of Vaccinia G9 Identifies Residues Essential for Membrane Fusion and Complex Assembly

Chiu, H.-J.; Chang, W.; Wang, H.-C.

10.1101/2025.04.22.650039 — microbiology — Posted on 2025-04-23

1347 A single valine to leucine switch disrupts Plasmodium falciparum AP2-G DNA binding and reveals the role of GDV1 in ap2-g activation.

Prajapati, S. K.; Dong, J. X.; Morahan, B. J.; Dotrang, T.; Barbeau, M. C.; Williams, A. E.; Hupalo, D.; Wilkerson, M. D.; Dalgard, C. L.; Kafsack, B. F. C.; Llinas, M.; Williamson, K. C.

10.1101/2025.04.22.648970 — microbiology — Posted on 2025-04-23

1348 Dietary Protein Sources Shape Gut Microbiome: Insights from Meta-analysis and Machine Learning

ADEJUMO, S. A.; Das, P.; Ghimire, S.; Kin Yun Lim, C.; Malas, J.; Allen, J.; Hampton-Marcell, J. A.

10.1101/2025.04.23.650130 — microbiology — Posted on 2025-04-23

1349 Quantitative insights into the efficacy of genome-resolved surveys of microbial communities through ribosomal protein phylogeography and EcoPhylo

Schechter, M. S.; Trigodet, F.; Veseli, I. A.; Miller, S. E.; Klein, M. L.; Sever, M.; Maignien, L.; Delmont, T. O.; Light, S. H.; Eren, A. M.

10.1101/2025.01.15.633187 — microbiology — Posted on 2025-04-23

1350 The effect of different milk pretreatment methods on microbiome community development during Herrgards cheese production and ripening.

Rodriguez, J. A.; Santos-Bay, L.; Narechania, A.; Caroe, C.; Siren, K.; Mak, S. S. T.; Broman Nielsen, I.; Ramsoe, M.; Ponten, T. S.; Lillevang, S.; Tranberg Andersen, L.; Gilbert, M. T. P.

10.1101/2025.04.23.648337 — microbiology — Posted on 2025-04-23

1351 Activation dynamics and assembly of root zone soil bacterial communities in response to stress-associated phytohormones

Bandopadhyay, S.; Bagchi, O.; Shade, A.

10.1101/2025.04.23.650272 — microbiology — Posted on 2025-04-23

1352 Antigen avidity drives the durability of the vaccine immune response.

Weidner, N. G.; Padilla, M. V.; Pruitt, L.; Cottrell, C. A.; Gonzales, K.; Kalyuzhniy, O.; Kubitz, M.; Alavi, N.; Phelps, N.; Weglarz, M.; Schief, W. R.; Abbott, R. K.

10.1101/2025.04.18.649567 — immunology — Posted on 2025-04-23

1353 A temporally restricted function of the Dopamine receptor Dop1R2 during memory formation

Kaldun, J. C.; Calia, E.; Bangalore Mukunda, G. C.; Fritsch, C.; Komarov, N.; Sprecher, S. G.

10.1101/2024.05.29.594954 — neuroscience — Posted on 2025-04-23

1354 Pan-cancer Analysis Identified Ectopic RUNX1T1 Associated with Lineage Plasticity

Jiang, Y.; Cheng, S.; Kim, I. Y.; Deng, S.; Mu, P.

10.1101/2025.04.18.649575 — cancer biology — Posted on 2025-04-23

1355 Discovery of Novel Trypanothione Reductase Inhibitors through Pharmacophore Modeling, virtual Screening and Molecular Dynamics Simulations. New insights for Human African Trypanosomiasis

EVANS, E. M.; Taofeek, O. O.; Gwira, T. M.; Morang'a, C. M.; Musyoka, T. M.; Nyanjom, S. G.

10.1101/2025.04.18.649577 — bioinformatics — Posted on 2025-04-23

1356 The structure, folding kinetics and dynamics of long poly(UG) RNA

Petersen, R. J.; Vivek, R.; Tonelli, M.; Roschdi, S.; Butcher, S. E.

10.1101/2025.04.22.650042 — biochemistry — Posted on 2025-04-23

1357 Quantified Dynamics-Property Relationships: Data-Efficient Protein Engineering with Machine Learning of Protein Dynamics

Burgin, T. E.

10.1101/2025.04.23.650227 — biochemistry — Posted on 2025-04-23

1358 Septin7 is essential in early hematopoiesis, but redundant at later stages

Ronkina, N.; Verheyden, N.; Gambhir, P.; Laass, K.; Yakovleva, T.; Doerrie, A.; Abbey, M.; Menon, M. B.; Selich, A.; Galla, M.; Rothe, M.; Schambach, A.; Krueger, A.; Kotlyarov, A.; Gaestel, M.

10.1101/2025.04.22.649981 — biochemistry — Posted on 2025-04-23

1359 Ecologically Significant Genetic Loci of P. allii: Contributions to Pathogenesis and Competition

Shin, G. Y.; De Armas, S.; Galvan, G. A.; Siri, M. I.; vinatzer, B. A.; Asselin, J. A. E.; Stodghill, P.; Zhao, M.; Dutta, B.; Tambong, J.; Kvitko, B. H.

10.1101/2025.04.23.650278 — genomics — Posted on 2025-04-23

1360 Aviadenovirus structure: a highly thermostable capsid in the absence of stabilizing proteins

Perez-Illana, M.; Schachner, A.; Hernando-Perez, M.; Condezo, G.; Paradela, A.; Martinez, M.; Marabini, R.; Hess, M.; San Martin, C.

10.1101/2025.04.23.650237 — molecular biology — Posted on 2025-04-23

1361 MotorBench: A Cryo-Electron Tomography Dataset of Bacterial Flagellar Motors for Testing Detection Algorithms

Owens, C. B.; Morse, B. S.; Darley, A. J.; Hart, T. J.; Webb, R.; Maggi, S.; Jensen, G. J.; Ward, M. M.; Reade, W. C.; Kaplan, M.; Hart, G. L. W.

10.1101/2025.04.23.650258 — molecular biology — Posted on 2025-04-23

1362 Mechanistic insights and clinical implications of cross-reactive anti-prophage antibodies and bacterial heteroresistance on phage therapeutic failure

Gordillo Altamirano, F. L.; Subedi, D.; Beiers, M.; Bucher, M. J.; Dahlman, S.; Patel, D. M.; Parker, M.; Korneev, D.; Pragastis, K.; Wisniewski, J.; Rees, C.; Ramshaw, H.; Khan, S.; Gardiner, B.; Hammerschlag, Y.; Keating, D.; Kotsimbos, T.; Hawkey, J.; Barr, J. J.; Peleg, A. Y.

10.1101/2025.04.22.650118 — microbiology — Posted on 2025-04-23

1363 Isolation and characterization of TayeBlu, a novel bacteriophage of Azotobacter vinelandii

Akanbi, T. M.; Labat, M.; Sun, T.; Smith, D. A.; Bagby, S. C.

10.1101/2025.04.23.650044 — microbiology — Posted on 2025-04-23

1364 Starvation drives co-existence in cross-feeding bacterial populations

McLaughlin, W. F.; Behringer, M. G.

10.1101/2025.04.22.650053 — microbiology — Posted on 2025-04-23

1365 Structural modeling reveals the allosteric switch controlling the chitin utilization program of Vibrio cholerae

Anderson, H. S.; Dalia, A. B.

10.1101/2025.04.22.650076 — microbiology — Posted on 2025-04-23

1366 Cultivating Future Materials: Artificial Symbiosis for Bulk Production of Bacterial Cellulose Composites

Yu, K.; Chua, S. T.; Smith, A.; Smith, A. G.; Ellis, T.; Vignolini, S.

10.1101/2025.04.23.650277 — microbiology — Posted on 2025-04-23

1367 Function-Based Selection of Synthetic Communities Enables Mechanistic Microbiome Studies

Hitch, T. C. A.; Bosch, J.; Bolsega, S.; Deschamps, C.; Etienne-Mesmin, L.; Treichel, N. S.; Blanquet-Diot, S.; Ocvirk, S.; Basic, M.; Clavel, T.

10.1101/2025.04.23.650235 — microbiology — Posted on 2025-04-23

1368 Gut Microbiota Dysbiosis and Short-chain Fatty Acid alterations in Pediatric New-Onset Type 1 diabetes with Ketoacidosis

Liu, Y.; Lin, H.; Zhu, M.; Chen, X.; Yu, Z.; Dong, G.; Ni, Y.; Fu, J.

10.1101/2025.04.22.650027 — microbiology — Posted on 2025-04-23

1369 Modeling simian immunodeficiency virus (SIV) latency in primary rhesus macaque CD4+ T cells

Matschke, L. M.; Reynolds, M. R.

10.1101/2025.04.22.650029 — immunology — Posted on 2025-04-23

1370 Mesoscale Imaging of Cortical Sensorimotor Integration in Huntington's Disease Mice During Reward-Guided Behaviour

Trappenberg, K.; Ramandi, D.; Mackay, J.; Murphy, T. H.; Raymond, L.

10.1101/2025.04.23.648272 — neuroscience — Posted on 2025-04-23

1371 Time-series RNA-Seq and data-driven network inference unveil dynamics of cell activation, survival and crosstalk in Chronic Lymphocytic Leukaemia in vitro models

Marku, M.; Chenel, H.; Bordenave, J.; Hurtado, M.; Domagala, M.; Raynal, F.; Poupot, M.; Ysebaert, L.; Zinovyev, A.; Pancaldi, V.

10.1101/2025.04.20.649300 — systems biology — Posted on 2025-04-23

1372 Parameter Estimation and Model Selection for the Quantitative Analysis of Oncolytic Virus Therapy in Zebrafish

Liu, Y.; Pathirana, D.; Hasenauer, J.

10.1101/2025.04.23.649270 — systems biology — Posted on 2025-04-23

1373 VasoTracker 2: An Open-source Platform for Quantitative Analysis of Vascular Reactivity and Function

Lee, M. D.; Osborne, C.; Stevenson, R.; MacDonald, A.; Ebner, G.; Jeffrey, D. A.; MacDonald, M. A.; Zhang, X.; Buckley, C.; Dabertrand, F.; Machin, D. R.; Au, J.; Harraz, O. F.; Tykocki, N.; McCarron, J. G.; Wilson, C.

10.1101/2025.04.23.648411 — physiology — Posted on 2025-04-23

1374 Enhanced efficacy of a specific HDAC3 inhibitor in combination with 5-Azacitidine against diffuse large B-cell lymphoma

Calaud, C.; Serrano-Lopez, E.; Cluse, L.; Todorovski, I.; Mardivirin, T.; Teater, M.; Maarad, A.; Tawfic, N.; Rutaquio, S.; Fraser, P. J.; Guiraud, K.; Yoannidis, D.; Kerreneur, E.; Jacquel, A.; Melnick, A. M.; Johnstone, R. W.; Dominguez, P. M.

10.1101/2025.04.21.648509 — cancer biology — Posted on 2025-04-23

1375 Co-phagocytosis of VEGFA with HER2-overexpressing cancer cells induced by HER2-VEGFA BsAb improves antitumor responses

Lu, Y.; Qiu, S.; Fan, Z.

10.1101/2025.04.22.648615 — cancer biology — Posted on 2025-04-23

1376 A flaw in using pre-trained pLLMs in protein-protein interaction inference models

Szymborski, J.; Emad, A.

10.1101/2025.04.21.649858 — bioinformatics — Posted on 2025-04-23

1377 AOP-helpFinder 3.0: from text mining to network visualization of key event relationships, and knowledge integration from multi-sources.

Jaylet, T.; Jornod, F.; Capdet, Q.; Armant, O.; Audouze, K.

10.1101/2025.04.22.648318 — bioinformatics — Posted on 2025-04-23

1378 rnaends: an R package targeted to study the exact RNA ends at the nucleotide resolution

Caetano, T.; Redder, P.; Fichant, G.; Barriot, R.

10.1101/2025.04.18.649472 — bioinformatics — Posted on 2025-04-23

1379 Development a computational framework for risk evaluation of emerging flu viruses based on genomic sequences and AI

Li, H.; Feng, Y.; Lu, C.; Fu, P.; Wang, X.; Yang, L.; Shu, Y.; Jiang, T.; Wang, D.; Peng, Y.

10.1101/2025.04.18.649608 — bioinformatics — Posted on 2025-04-23

1380 Chimeric Reference Panels for Genomic Imputation

Zhou, M.; James, M.; Engelstaedter, J.; Ortiz-Barrientos, D.

10.1101/2025.04.22.648973 — bioinformatics — Posted on 2025-04-23

1381 Bioengineering of the implantable vascularized endocrine constructs for insulin delivery suitable for clinical upscaling

10.1101/2025.04.19.647461 — bioengineering — Posted on 2025-04-23

1382 Single-Cell Epigenomics Uncovers Heterochromatin Instability and Transcription Factor Dysfunction during Mouse Brain Aging

Amaral, M. L.; Mamde, S.; Miller, M.; Hou, X.; Arzavala, J.; Osteen, J.; Walker Smoot, E.; Yang, Q.; Eisner, E.; Zeng, Q.; Baez-Becerra, C. T.; Olness, J.; Kern, J. C.; Rink, J.; Johnson, N.; Barcoma, A.; Cho, S.; Cao, S.; Emerson, N.; Lee, J.; Willier, J.; Loe, T.; Jiao, H.; Zu, S.; Zhu, Q.; Preissl, S.; Wang, A.; Ecker, J.; Behrens, M. M.; Ren, B.

10.1101/2025.04.21.649585 — genomics — Posted on 2025-04-23

1383 Azurify integrates cancer genomics with machine learning to classify the clinical significance of somatic variants

Bigdeli, A.; Chandrashekar, D. S.; Chitturi, A.; Rushton, C.; Mackinnon, A. C.; Segal, J.; Harada, S.; Sacan, A.; Faryabi, R. B.

10.1101/2025.04.18.649588 — genomics — Posted on 2025-04-23

1384 Biodiversity temporal trends are reshaping food web structure and redundancy in riverine ecosystems

Danet, A.; El Madouri, L.; Bonnaffe, W.; Beckerman, A. P.; Mouchet, M.; Fontaine, C.; Thebault, E.

10.1101/2025.04.23.649202 — ecology — Posted on 2025-04-23

1385 Effects of food availability on larval development during ontogenetic niche shift in a marine annelid

Randel, N.

10.1101/2025.04.20.649073 — ecology — Posted on 2025-04-23

1386 Targeting RhoA activity rejuvenates aged hematopoietic stem cells

Mejia-Ramirez, E.; Ianez-Picazo, P.; Walter, B.; Montserrat-Vazquez, S.; Affuso, F.; Wieser, S.; Pezzano, F.; Reymond, L.; Castillo-Robles, J.; Matteini, F.; Mularoni, L.; Macia, D.; Raya, A.; Ruprecht, V.; Zheng, Y.; Petrone, P.; Florian, M. C.

10.1101/2025.04.23.647902 — cell biology — Posted on 2025-04-23

1387 Codon-dependent regulation of mRNA translation and stability by ZC3H7A and ZC3H7B RNA-binding proteins

Harris Snell, P. L.; Naeli, P.; Garzia, A.; Waldron, J. A.; Chatterjee, S.; McGirr, T.; Ladak, R. J.; Choi, J.-H.; Luo, J.; Leino, S.; Jess, N.; Shariati, A.; Soto Rodriguez, X.; Gkogkas, C. G.; Sonenberg, N.; Tuschl, T.; Maguire, S.; Jafarnejad, S. M.

10.1101/2025.04.21.649502 — cell biology — Posted on 2025-04-23

1388 Harnessing the Power of Single-Cell Large Language Models with Parameter Efficient Fine-Tuning using scPEFT

He, F.; Fei, R.; Krull, J. E.; Zhang, X.; Gao, M.; Su, L.; Chen, Y.; Yu, Y.; Li, J.; Jin, B.; Chang, Y.; Ma, A.; Ma, Q.; Xu, D.

10.1101/2025.04.21.649754 — cell biology — Posted on 2025-04-23

1389 SARS-CoV-2 causes chronic lung inflammation and impaired respiratory capacity in aged Roborovski dwarf hamsters

Karimi, A.; Lieber, C. M.; Sakamoto, K.; Plemper, R. K.

10.1101/2025.04.23.650177 — microbiology — Posted on 2025-04-23

1390 Interprotomer Crosstalk in Mosaic Viral Glycoprotein Trimers Provides Insight into Polyvalent Immunogen Co-assembly

Chen, C.; Lovendahl, K.; Overbaugh, J.; Lee, K. K.

10.1101/2025.04.22.649918 — microbiology — Posted on 2025-04-23

1391 A direct RNA-seq-based EBV Latency Transcriptome Offers Insights into the Biogenesis of EBV Gene Products.

Mamane-Logsdon, A.; Zane, I.; Chong, C. S.; Chou, O. H. I.; Rawal, M.; Gillman, A. C. T.; Wongwiwat, W.; Donovan-Banfield, I.; Matthews, D. A.; White, R. E.

10.1101/2025.04.23.648900 — microbiology — Posted on 2025-04-23

1392 Proviruses in CD4+ T cells reactive to autologous antigens contribute to nonsuppressible HIV-1 viremia

Wu, F.; Moskovjlevic, M.; Dragoni, F.; Jayaraman, S.; Board, N. L.; Camilo-Contreras, A.; Bernal, S.; Hariharan, V.; Zhang, H.; Lai, J.; Singhal, A.; Poulin, S.; Chano, F.; Chamberland, A.; Tremblay, C.; Zoltik, M.; Hoffmann, C. J.; Jones, J. L.; Larman, H. B.; Montaner, L. J.; Siliciano, J. D.; Siliciano, R. F.; Simonetti, F. R.

10.1101/2025.04.19.649587 — immunology — Posted on 2025-04-23

1393 Attention induced perceptual traveling waves in binocular rivalry

Cardoso, J. V. X.; Li, H.-H.; Heeger, D. J.; Dugue, L.

10.1101/2025.04.18.649496 — neuroscience — Posted on 2025-04-23

1394 FMed-Diffusion Federated Learning on Medical Image Diffusion

Perumal, M.; Srinivas, M.

10.1101/2025.04.22.649958 — neuroscience — Posted on 2025-04-23

1395 Short Report: A Meta-Analysis of the Effects of Sleep Deprivation on the Cortical Transcriptome in Animal Models

Rhoads, C. A.; Hagenauer, M. H.; Xiong, J.; Hernandez, E.; Nguyen, D. M.; Saffron, A.; Flandreau, E. I.; Watson, S.; Akil, H.

10.1101/2025.04.21.648791 — neuroscience — Posted on 2025-04-23

1396 Resolving Oligomeric States of Photoactivatable Proteins in Live Cells via Photon Counting Histogram Analysis

Camp, T.; Li, Z.; Li, Y.; Oh, T.-J.; Zhang, K.

10.1101/2025.04.18.649599 — biophysics — Posted on 2025-04-23

1397 Novel AI-based approach for cell type deconvolution in Visium datasets when reference scRNA-seqs include multiple minor cell types

Taguchi, Y.-h.; Turki, T.

10.1101/2025.04.18.649484 — bioinformatics — Posted on 2025-04-23

1398 The Drosophila G protein-coupled receptor, GulpR, is essential for lipid mobilization in response to nutrient-limitation

Barraza, D.; Ding, X.; Wang, Z.; Jugder, B.-E.; Watnick, P. I.

10.1101/2025.04.19.649675 — genetics — Posted on 2025-04-23

1399 Essential Role of Protein Kinase R in the Pathogenesis of Pulmonary Veno-occlusive Disease

Prabhakar, A.; Kumar, R.; Wadhwa, M.; Barpanda, A.; Lyons, J.; Gowda, A.; Gupta, S.; Arvind, A.; Ghatpande, P.; Wiita, A.; Graham, B. B.; Lagna, G.; Hata, A.

10.1101/2025.04.18.649514 — cell biology — Posted on 2025-04-23

1400 Monitoring the poroelastic response of collagen gels with embedded senescent fibroblasts reveals tissue softening associated with collagen network reorganization

Cacheux, J.; Quenan, T.; Alcaide, D.; Ordonez-Miranda, J.; Jalabert, L.; Nakano, S.; Nakanishi, M.; Cordelier, P.; Bancaud, A.; Matsunaga, Y. T.

10.1101/2025.04.18.649513 — biophysics — Posted on 2025-04-23

1401 Sex-dimorphic effects of neuromelanin buildup in rodent nigral dopamine neurons: implications for sex-biased vulnerability in Parkinson's disease

D'Addario, S. L.; Massaro Cenere, M.; Cossa, F.; Scaricamazza, S.; Nesci, V.; D'Ottavio, G.; Caprioli, D.; Ferri, A.; Vila, M.; Ledonne, A.; Mercuri, N. B.

10.1101/2025.04.18.649338 — neuroscience — Posted on 2025-04-23

1402 Synergistic roles of Aquaporin 5 and Intra- and Extracellular Carbonic Anhydrases in promoting CO2 Diffusion across the Xenopus Oocyte Plasma Membrane

Wang, D.; Moss, F. J.; Boron, W. F.

10.1101/2025.04.08.647833 — physiology — Posted on 2025-04-23

1403 Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Vascular Endothelial Dysfunction: Translational Evidence of Prevention with Senolytic Treatment

Venkatasubramanian, R.; Mahoney, S. A.; Hutton, D. A.; VanDongen, N. S.; Brunt, V. E.; Greenberg, N. T.; Longtine, A. G.; Brandt, L.; Beyer, A. M.; Melov, S.; Campisi, J.; Rossman, M. J.; Seals, D. R.; Clayton, Z. S.

10.1101/2025.04.19.649672 — physiology — Posted on 2025-04-23

1404 GOALS: Gene Ontology Analysis with Layered Shells for Enhanced Functional Insight and Visualization

Yue, Z.; Welner, R. S.; Willey, C. D.; Amin, R.; Chen, J. Y.

10.1101/2025.04.22.650095 — bioinformatics — Posted on 2025-04-23

1405 ShinyCell2: An extended library for simple and sharable visualisation of spatial, peak-based and multi-omic single-cell data

Chen, B. J.; Lim, Y. Y.; Yang, X.; Wang, L.; Rackham, O. J.; Ouyang, J. F.

10.1101/2025.04.22.650045 — bioinformatics — Posted on 2025-04-23

1406 GAT-HiC: Efficient Reconstruction of 3D Chromosome Structure via Residual Graph Attention Neural Networks

Kaya, B.; Sefer, E.

10.1101/2025.04.18.649477 — bioinformatics — Posted on 2025-04-23

1407 Adaptations in wing morphology rather than wingbeat kinematics enable flight in small hoverfly species

Le Roy, C.; Tervelde, N.; Engels, T.; Muijres, F.

10.1101/2024.04.08.588585 — evolutionary biology — Posted on 2025-04-23

1408 An Epidemic Diversity conceptual model explains how host genetic diversity affects variation in parasite success

Paplauskas, S.; Duthie, A. B.; Tinsley, M.

10.1101/2024.05.28.596150 — ecology — Posted on 2025-04-23

1409 An animal-free bioprocess to synthesize 3D human matrix scaffolds using mesenchymal stromal cells

Stein, S.; Braid, L.

10.1101/2025.04.17.649452 — cell biology — Posted on 2025-04-23

1410 TNIP1 and Autophagy Receptors Regulate STING Signaling

Bunker, E. N.; Fischer, T. D.; Zhu, P.-P.; Le Guerroue, F.; Youle, R. J.

10.1101/2025.04.21.649822 — cell biology — Posted on 2025-04-23

1411 Cross-reactive sarbecovirus antibodies induced by mosaic RBD-nanoparticles

Fan, C.; Keeffe, J. R.; Malecek, K. E.; Cohen, A. A.; West, A. P.; Baharani, V. A.; Rorick, A. V.; Gao, H.; Gnanapragasam, P. N. P.; Rho, S.; Alvarez, J.; Segovia, L. N.; Hatziioannou, T.; Bieniasz, P. D.; Bjorkman, P. J.

10.1101/2025.01.02.631145 — immunology — Posted on 2025-04-23

1412 A neuroprotective tetrapeptide for treatment of acute traumatic brain injury

Mann, A. P.; Hussain, S.; Scodeller, P.; Moore, H. N. B.; Sherazee, E.; Russo, R. M.; Ruoslahti, E.

10.1101/2025.04.17.649010 — neuroscience — Posted on 2025-04-23

1413 Small-world scale-free brain graphs from EEG

Khalili, M. D.; Abootalebi, V.; Saeedi-Sourck, H.; Santoro, A.; Behjat, H. H.

10.1101/2025.04.17.649421 — neuroscience — Posted on 2025-04-23

1414 How the visual brain can learn to parse images using a multiscale, incremental grouping process

Mollard, S.; Bohte, S.; Roelfsema, P.

10.1101/2024.06.17.599272 — neuroscience — Posted on 2025-04-23

1415 A Context-Free Model of Savings in Motor Learning

Shahbazi, M.; Codol, O.; Michaels, J. A.; Gribble, P. L.

10.1101/2025.03.26.645562 — neuroscience — Posted on 2025-04-23

1416 Rigidity transitions in a 3D active foam model of cell monolayers with frictional contact interactions

Vangheel, J.; Ramon, H.; Smeets, B.

10.1101/2025.04.17.649329 — biophysics — Posted on 2025-04-23

1417 AT vs. GC binding of protamine-template: A microscopic understanding through molecular dynamics and binding free energies

Mandal, S.; Chhetri, K. B.; Jang, Y. H.; Lansac, Y.; Maiti, P. K.

10.1101/2025.04.17.649418 — biophysics — Posted on 2025-04-23

1418 EpitopeTransfer: a Phylogeny-aware transfer learning framework for taxon-specific linear B-cell epitope prediction

Leite, L. P.; de Campos, T. E.; Lobo, F. P.; Campelo, F.

10.1101/2025.04.17.649425 — bioinformatics — Posted on 2025-04-23

1419 Mechanistic Insights into Proteomic Mutation-Phenotype Linkages from Tiling Mutagenesis Screens

He, W.; Huang, J.-W.; Wang, Y.; Hayward, S. B.; Leuzzi, G.; Fu, R.; Wang, S.; Vaitsiankova, A.; Bedford, M. T.; Guerois, R.; Ciccia, A.; Xu, H.

10.1101/2025.04.17.649336 — bioinformatics — Posted on 2025-04-23

1420 Fine-Tuning Protein Language Models Unlocks the Potential of Underrepresented Viral Proteomes

Sawhney, R.; Ferrell, B. D.; Dejean, T.; Schreiber, Z.; Harrigan, W.; Polson, S. W.; Wommack, K. E.; Belcaid, M.

10.1101/2025.04.17.649224 — bioinformatics — Posted on 2025-04-23

1421 Measurement and prediction of unmixing-dependent spreading in spectral flow cytometry panels

Mage, P. L.; Konecny, A. J.; Mair, F.

10.1101/2025.04.17.649396 — bioinformatics — Posted on 2025-04-23

1422 Fibroblasts regulate lymphatic barrier functions in a tissue dependent manner

Ejazi, S. A.; Abdulkarimu, A.; Hsiao, T.; Garcia-Vivas, R. D.; Maisel, K.

10.1101/2025.04.17.649442 — bioengineering — Posted on 2025-04-23

1423 Exploring non-invasive sexing of early chick embryos in intact eggs using Laser Speckle Contrast Imaging (LSCI) and Deep Neural Network (DNN)

Mahler, S.; Arora, A.; Readhead, C.; Yin, S.; Hari, S. N.; Wang, E.; Moxley, C. I.; Adeboye, A. A.; Dong, Z.; Zhou, H.; Chen, X.; Bronner, M.; Yang, C.

10.1101/2025.04.17.649355 — bioengineering — Posted on 2025-04-23

1424 Polysomal profiling coupled to allele-specific proteomics reveals an EIF4H tranSNP allele possessing higher mRNA translation potential.

Hamadou, M. H.; Alunno, L.; Peroni, D.; Pancher, M.; Venturelli, T.; Belli, R.; Dassi, E.; Romanel, A.; Inga, A.

10.1101/2025.04.17.649328 — genetics — Posted on 2025-04-23

1425 Fitness landscapes for an FMN riboswitch in S. pneumoniae reveals complex interplay between antibiotic inhibitors and the native ligand as well as insights into the mechanism of action

Korn, R. J.; Meyer, M. M.

10.1101/2025.04.17.649428 — genetics — Posted on 2025-04-23

1426 Uev1A counteracts oncogenic Ras stimuli in both polyploid and diploid cells

Zhang, Q.; Wang, Y.; Fu, X.; Wang, Z.; Zhang, Y.; Yan, L.; Wang, Y.; Yang, M.; Song, D.; Zhang, R.; Zhang, H.; Wu, S.; Zhao, S.

10.1101/2025.04.17.649440 — cell biology — Posted on 2025-04-23

1427 Subtle Cellular Phenotypes Inform Pathological and Benign Genetic Mutants in the Iduronidase-2 Sulfatase Gene

Viswanathan, A.; Elia, S. N.; Le, S. Q.; Doray, B.; Waligorski, J. E.; Kelley, K.; Buchser, W. J.; Dickson, P. I.

10.1101/2025.04.17.649412 — cell biology — Posted on 2025-04-23

1428 Acyl-coA binding protein AcbdA regulates peroxisome hitchhiking on early endosomes

Driscoll, B.; Fountain, M. B.; Gates, I. N.; Abdollahi, R.; Langley, A. M.; Owens, M. B.; Christensen, J. R.; Salogiannis, J.

10.1101/2025.04.17.649231 — cell biology — Posted on 2025-04-23

1429 SynGAP forms biocondensates at sub-micromolar concentrations and recruits PSD95 and receptor oligomers, functioning as a key initiator of PSD formation

Acharya, S.; Tsunoyama, T. A.; Hoffmann, C.; Aguilar, P. G.; Meshcheryakova, I.; Nakamura-Norimoto, A.; Mastro, T.; Walkup, W. G.; Fujiwara, T. K.; Kennedy, M. B.; Milovanovic, D.; Kusumi, A.

10.1101/2025.04.22.649955 — neuroscience — Posted on 2025-04-23

1430 Saccades orchestrate intraocular glucose to shape visual responses in birds

Xu, X.; Xiao, T.; Chen, Y.; Song, L.; Wu, C.; Wang, Q.; Zhang, T.; Yang, Y.

10.1101/2025.04.17.649318 — neuroscience — Posted on 2025-04-23

1431 Adolescent Binge Ethanol Exposure Confers Lasting Alcohol Tolerance across a Cumulative Ethanol Challenge in Adulthood: Involvement of Proinflammatory HMGB1 Signaling

Crews, F. T.; Vetreno, R.

10.1101/2025.04.17.649339 — neuroscience — Posted on 2025-04-23

1432 M-ECG: Extracting Heart Signals with a Novel Computational Analysis of Magnetoencephalography Data

Izadysadr, A.; Bagherzadeh, H. S.; Stapleton-Kotloski, J.; Popli, G.; O`Donovan, C.; Godwin, D.

10.1101/2025.04.17.649325 — neuroscience — Posted on 2025-04-23

1433 Mixing features of transcription factors and genes enables accurate prediction of gene regulation relationships for unknown transcription factors

Okubo, R.; Morikura, T.; Hiki, Y.; Tokuoka, Y.; Kobayashi, T. J.; Yamada, T. G.; Funahashi, A.

10.1101/2025.04.17.649264 — systems biology — Posted on 2025-04-23

1434 Exploring the mechanism of kaji-ichigoside F1 on bacterial pneumonia based on the network pharmacology and transcriptome

Yang, J.; Yang, X.; Wu, L.; Min, C.

10.1101/2025.04.17.649383 — pharmacology and toxicology — Posted on 2025-04-23

1435 A single vesicle fluorescence microscopy platform to quantify phospholipid scrambling

Veit, S.; Dearden, G. I.; Menon, K. M.; Noor, F.; Menon, A. K.; Pomorski, T. G.

10.1101/2025.04.17.649308 — biophysics — Posted on 2025-04-23

1436 Structural Insights into Kainate Receptor Desensitization

zhou, c.; Tajima, N.; Segura-Covarrubias, G.

10.1101/2025.03.27.645769 — biophysics — Posted on 2025-04-23

1437 Mechanistic Insights into Crossover-Dependent Stability and Exceptional Resistance of PX/JX Nanostructures to DNase I using Enhanced Sampling

Mandal, S.; Chandrasekaran, A. R.; Maiti, P. K.

10.1101/2025.04.17.649409 — biophysics — Posted on 2025-04-23

1438 scStudio: A User-Friendly Web Application Empowering Non-Computational Users with Intuitive scRNA-seq Data Analysis

Bica, M.; Serre, K.; Barbosa-Morais, N. L.

10.1101/2025.04.17.649161 — bioinformatics — Posted on 2025-04-23

1439 MTBseq-nf: Enabling Scalable Tuberculosis Genomics "Big Data" Analysis through a User-Friendly Nextflow Wrapper for MTBseq pipeline

Sharma, A.; Marcon, D. J.; Loubser, J.; Batista Lima, K. V.; van der Spuy, G.; Costa Conceicao, E.

10.1101/2025.04.17.649337 — bioinformatics — Posted on 2025-04-23

1440 Crowdsourced Protein Design: Lessons From the Adaptyv EGFR Binder Competition

Cotet, T.-S.; Krawczuk, I.; Pacesa, M.; Nickel, L.; Correia, B. E.; Haas, N.; Qamar, A.; Challacombe, C. A.; Kidger, P.; Ferragu, C.; Naka, A.; Castorina, L. V.; Subr, K.; Kluonis, T.; Stam, M. J.; Unal, S. M.; Wood, C. W.; Stocco, F.; Ferruz, N.; Kurumida, Y.; Calia, C. N.; Paesani, F.; Machado, L. d. A.; Belot, E.; Gitter, A.; Campbell, M. J.; Hallee, L.; Adaptyv Competition Organizers,

10.1101/2025.04.17.648362 — bioengineering — Posted on 2025-04-23

1441 Probing mycelium mechanics and taste: The moist and fibrous signature of fungi steak

Vervenne, T.; St. Pierre, S. R.; Famaey, N.; Kuhl, E.

10.1101/2025.04.17.649423 — bioengineering — Posted on 2025-04-23

1442 The ISW1 and CHD1 chromatin remodelers suppress global nucleosome dynamics in living yeast cells

Xu, Z.; Prajapati, H. K.; Eriksson, P. R.; Clark, D. J.

10.1101/2025.04.17.649351 — genomics — Posted on 2025-04-23

1443 Trans-ancestry Mendelian Randomization Discovers Novel Causal Genes for Autoimmune Disease Traits

Chen, S.; Wang, C.; Taylor, K.; Rotter, J.; Guo, X.; Rich, S. S.; Manichaikul, A. W.; Liu, D.

10.1101/2025.04.17.649410 — genetics — Posted on 2025-04-23

1444 Loss of direct binding of Leishmania profilin with actin adversely affected its functions and interactions with other cellular proteins

Raja, S.; Rai, P. K.; S, H. K.; Thiyagarajan, S.; Gupta, C. M.

10.1101/2025.04.17.649292 — cell biology — Posted on 2025-04-23

1445 Characterisation of Marteilia cocosarum in the Wash Estuary, UK, linked to mass mortalities of cockles (Cerastoderma edule), and its relationship to closely related species

Tidy, A. M.; Jessop, R.; Ward, G. M.; Green, M. J.; Bateman, K. S.; Bass, D.; Hunt, J. E.; Ross, S. H.; Hooper, C.

10.1101/2025.02.13.638039 — molecular biology — Posted on 2025-04-23

1446 Neuropilin 2 functions as a co-inhibitory receptor to regulate antigen-induced inflammation and allograft rejection

Wedel, J.; Kochupurakkal, N.; Kong, S. W.; Bose, S.; Lee, J.-W.; Maslyar, M.; Alsairafi, B.; Macleod, K.; Liu, K.; Zhang, H.; Komatsu, M.; Nakayama, H.; Bielenberg, D. R.; Briscoe, D.

10.1101/2025.04.17.648233 — immunology — Posted on 2025-04-23

1447 Respiration shapes the neural dynamics of successful remembering in humans.

Bullon Tarraso, E.; Schwimmbeck, F.; Petzka, M.; Staudigl, T.; Staresina, B. P.; Schreiner, T.

10.1101/2025.04.17.649286 — neuroscience — Posted on 2025-04-23

1448 Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer's disease

10.1101/2025.04.17.648358 — neuroscience — Posted on 2025-04-23

1449 DAGLα/β, 2-AG release, and Parkinson's Disease: Exploring a causal link.

DOHERTY, P.; Williams, G.

10.1101/2025.04.17.649373 — neuroscience — Posted on 2025-04-23

1450 Single-cell and spatial detection of senescent cells using DeepScence

Qu, Y.; Ji, B.; Dong, R.; Gu, L.; Chan, C.; Xie, J.; Glass, C.; Wang, X.-F.; Nixon, A.; Ji, Z.

10.1101/2023.11.21.568150 — bioinformatics — Posted on 2025-04-23

1451 Benchmarking circRNA Detection Tools from Long-Read Sequencing Using Data-Driven and Flexible Simulation Framework

Rusakovich, A.; CORRE, S.; Cadieu, E.; Fraboulet, R.-M.; Galibert, M.-D.; Derrien, T.; Blum, Y.

10.1101/2025.04.17.649290 — bioinformatics — Posted on 2025-04-23

1452 EasyMultiProfiler: An Efficient Multi-Omics Data Integration and Analysis Workflow for Microbiome Research

Liu, B.; Liu, Y.; Xu, S.; Wu, Q.; Wu, D.; Zhan, L.; Liao, Y.; Mai, Y.; Zheng, M.; Wang, S.; Chen, Y.; Huang, Z.; Luo, X.; Xie, Z.; Pan, X.; Yu, G.; Xie, L.

10.1101/2025.04.17.649266 — bioinformatics — Posted on 2025-04-23

1453 Thermal cycling resets the irreversible liquid-to-solid transition of peptide condensates during aging

Anwar, A. K.; Li, T.; Shen, Y.

10.1101/2025.04.16.649229 — bioengineering — Posted on 2025-04-23

1454 VARS-fUSI: Variable Sampling for Fast and Efficient Functional Ultrasound Imaging using Neural Operators

Tolooshams, B.; Lin, L.; Callier, T.; Wang, J.; Pal, S.; Chandrashekar, A.; Rabut, C.; Li, Z.; Blagden, C.; Norman, S. L.; Azizzadenesheli, K.; Liu, C.; Shapiro, M. G.; Andersen, R. A.; Anandkumar, A.

10.1101/2025.04.16.649237 — bioengineering — Posted on 2025-04-23

1455 Apremilast improves cardiomyocyte cohesion and arrhythmia in different models for arrhythmogenic cardiomyopathy

Stangner, K.; Dervishi, O.; Kuhnert, J.; Wendt, C.; Pathak, S.; Shoykhet, M.; Olivares Florez, S.; Moztarzadeh, S.; Opsteen, J.; Suniasih Wohlfarth, N. L. C.; Biller, R.; Graf, E.; Westphal, D. S.; Williams, T.; Gerull, B.; Saric, T.; Yeruva, S.; Waschke, J.

10.1101/2025.04.17.649297 — cell biology — Posted on 2025-04-23

1456 Optogenetic control of mechanotransduction based on light-induced homodimerization of talin

Nishimura, R.; Barnett, S. F. H.; Jain, K.; Huang, Z.; Goult, B. T.; Kanchanawong, P.

10.1101/2025.04.17.649301 — cell biology — Posted on 2025-04-23

1457 CD4 T cells acquire innate capability upon classical T cell activation

Yassini, N.; Goljat, E.; Panetti, C.; Rath, M.; Joller, N.

10.1101/2025.04.17.649269 — immunology — Posted on 2025-04-23

1458 Exogenous Thyroxine Increases Cardiac Nrf2-TRX in Insulin Resistant OLETF Rats

Mendez, D. A.; Hernandez Garcia, J.; Sonanez-Organis, J. G.; Hernandez Garcia, M.; Vazquez-Anaya, G.; Nishiyama, A.; Vazquez-Medina, J. P.; Ortiz, R. M.

10.1101/2025.04.16.649239 — physiology — Posted on 2025-04-23

1459 Viscoelastic characterization of cells in microfluidic channels with 3D hydrodynamic focusing

Hartmann, B.; Reichel, F.; Moeckel, C.; Guck, J.

10.1101/2025.04.17.649258 — biophysics — Posted on 2025-04-23

1460 Quantification of individual dataset contributions to prediction accuracy in cooperative learning

Dechantsreiter, D.; Kelly, R.; Lange, C.; Lasky-Su, J. A.; Hahn, G.

10.1101/2025.04.16.649215 — bioinformatics — Posted on 2025-04-23

1461 Face photo-based age acceleration predicts all-cause mortality and differs among occupations

Kiraly, B.; Fejes, I.; Kerepesi, C.

10.1101/2025.04.16.649078 — bioinformatics — Posted on 2025-04-23

1462 Modulation of viral replication, autophagy and apoptosis by induction and mutual regulation of transcription factors EB and E3 during coronavirus infection

Yang, B.; Fung, T. S.; Yuan, L.; Chen, R.; Liu, D.

10.1101/2025.04.21.648309 — microbiology — Posted on 2025-04-23

1463 Sequence variability of BamA and FadL candidate vaccinogens suggests divergent evolutionary paths of Treponema pallidum outer membrane proteins

Bettin, E. B.; Aghakhanian, F.; Hennelly, C.; Chen, W.; Davenport, T.; Hackl, S. T.; Grassmann, A. A.; Vargas-Cely, F.; Silva, S.; Garcia-Luna, J. A.; Ramirez, L. G.; Jiang, Y.; Yang, L.-G.; Zheng, h.; Yang, B.; Pospisilova, P.; ?majs, D.; Matoga, M. M.; Hoffman, I.; Lopez-Medina, E.; Nieselt, K.; Moody, M. A.; Sena, A. C.; Salazar, J. C.; Parr, J. B.; Caimano, M. J.; Hawley, K. L.; Radolf, J. D.

10.1101/2025.04.21.649848 — microbiology — Posted on 2025-04-23

1464 Conjugative transfer inhibition of IncA and IncC plasmids by pervasive SGI1-like elements via relaxosome assembly interference

Deschenes, F.; Durand, R.; Huguet, K. T.; Rivard, N.; Chagnon, C.; Planez, D.; Burrus, V.

10.1101/2025.04.21.649884 — microbiology — Posted on 2025-04-23

1465 Complete Protection Against Lethal Crimean-Congo Hemorrhagic Fever Virus (CCHFV) Challenge in Mice Afforded by Immunization with Modified mRNA Encoding the Nucleocapsid Protein (NP) Alone

Keskin, S.; Pavel, S. T. I.; Sak, R.; Bahadori, F.; Aslan, A. F.; Aktas, M.; Karakecili, F.; Kalkan, A.; Özdarendeli, A.; Doymaz, M. Z.

10.1101/2025.04.21.649815 — immunology — Posted on 2025-04-23

1466 The Effects of Antidepressants on the Hippocampus: A Meta-Analysis of Public Transcriptional Profiling Data

Geoghegan, E. M.; Hagenauer, M. H.; Hernandez, E.; Espinoza, S.; Flandreau, E. I.; Nguyen, P. T.; Bhuiyan, M. R.; Mensch, S.; Watson, S. J.; Akil, H.

10.1101/2025.04.21.648805 — neuroscience — Posted on 2025-04-23

1467 Exploration of Novel Biomarkers through a Precision Medicine Approach Using Multi-omics and Brain Organoids in Patients with Atypical Depression and Psychotic Symptoms

Ahn, I.; Chang, S.; Choi, S. H.; Han, J.; Kim, Y.

10.1101/2025.04.21.649748 — neuroscience — Posted on 2025-04-23

1468 Cryptovaranoides is not a squamate

Caldwell, M. W.; Brownstein, C. D.; Meyer, D. L.; Scarpetta, S. G.; Lee, M. S. Y.; Simoes, T. R.

10.1101/2025.04.18.649532 — paleontology — Posted on 2025-04-23

1469 Three-row stereocilia model predicts mammalian hair bundle behavior

Goyal, V.; Grosh, K.

10.1101/2025.04.17.649156 — biophysics — Posted on 2025-04-23

1470 Comparing Linear and Nonlinear Finite Element Models of Vertebral Strength Across the Thoracolumbar Spine: A Benchmark from Density-Calibrated Computed Tomography

Walle, M.; Matheson, B. E.; Boyd, S. K.

10.1101/2025.04.19.649449 — bioengineering — Posted on 2025-04-23

1471 Whole-Proteome Screening and Multi-Modal Profiling of Antigen-Specific CD4+ T Cells at Single-Cell Resolution

Zhang, R.; Qi, J.; McKasson, M.; Choi, J.; Gutierrez, V.; Brennan, C.; Hong, S.; Chour, W.; Ng, R. H.; Xie, J.; Yuan, D.; Webster, A.; Sidhu, S. K.; Anderson, A.; Chen, D.; Edmark, R.; Murray, K. M.; Li, S.; McDonald, C.; Rowen, L.; Wang, S.; Rasheed, Y.; Su, Y.; Wagner, J. R.; Chen, J.; Narwaly, K.; Fu, J.; Duven, A.; Forman, S. J.; Song, M.; Priceman, S.; Brown, C. E.; Ribas, A.; Wong, D.; Paulson, K. G.; Drescher, C. W.; Puig-Saus, C.; Goldman, J. D.; Trimble, C. L.; Heath, J. R.

10.1101/2025.04.21.649828 — bioengineering — Posted on 2025-04-23

1472 Activity of lysosomal exoglycosidases in blood serum and urine of patients with tick-borne and other lymphocytic meningitis.

Szajda, S. D.; Snarska, J.; Kepka, A.; Krzyzak, M.; Pancewicz, S.; Zwierz, K.; Minarowska, A. M.

10.1101/2025.04.22.649922 — biochemistry — Posted on 2025-04-23

1473 Theoretical origins of extreme cell differentiation irreversibility: a dynamic model of organismal size effects

Gao, Y.; Zhao, X.; Li, C.

10.1101/2025.04.20.649670 — evolutionary biology — Posted on 2025-04-23

1474 Daphnia-associated bacterial communities correlate with diet quantity, environmental conditions and epidemic size across natural outbreaks

Rajarajan, A.; Wolinska, J.; Walser, J.-C.; Tardent, N.; Kaeser, S.; Keller, E.; Spaak, P.

10.1101/2024.06.10.598240 — ecology — Posted on 2025-04-23

1475 Bigger is not always better: size-dependent fitness effects of adult crowding in Drosophila melanogaster

Rao, M.; Temura, C.; Mital, A.; Anvitha, S.; Joshi, A.

10.1101/2025.04.21.649761 — ecology — Posted on 2025-04-23

1476 Step-by-step protocol for making a knock-in Xenopus laevis to visualize endogenous gene expression

Kagawa, N.; Umesono, Y.; Suzuki, K.-i. T.; Mochii, M.

10.1101/2025.03.05.640691 — developmental biology — Posted on 2025-04-23

1477 Ketamine reverses chronic stress-induced behavioral changes via Ca2+-permeable AMPA receptors in mice

Flowers, J. C.; Vetter, P. E.; Wiles, M. J.; Roh, S. H.; Black, E. R.; Bouckova, E.; Wustrau, M. H.; Lee, R.; Lee, S.-H.; Kim, S.

10.1101/2024.10.07.616991 — neuroscience — Posted on 2025-04-23

1478 Investments in photoreceptors compete with investments in optics to determine eye design

Heras, F. J. H.; Laughlin, S. B.

10.1101/2024.01.21.576511 — zoology — Posted on 2025-04-23

1479 From Flies to Humans: A Conserved Role of CEBPZ, NOC2L, and NOC3L in rRNA Processing and Tumorigenesis.

Rambaldelli, G.; Manara, V.; Vutera Cuda, A.; Bertalot, G.; Penzo, M.; bellosta, p.

10.1101/2025.01.11.632529 — cancer biology — Posted on 2025-04-23

1480 Single cell spatial transcriptomics identifies coordinated cellular programs associated with good prognosis in microsatellite stable colorectal cancer

Karlsen, V. T.; Majid, U.; Lindholm, H. T.; Umu, S. U.; Vander-Elst, K. R.; Beitnes, A.-C. R.; Merok, M. A.; Hagen, K. T.; Nilsen, H. R.; Yaqub, S.; Baekkevold, E. S.; Domanska, D.; Jahnsen, F. L.

10.1101/2025.03.31.646286 — cancer biology — Posted on 2025-04-23

1481 Radiation-Induced Autophagy Regulates the Fibroblast Mitochondrial Stress Response and Crosstalk with Triple-Negative Breast Cancer Cells

Corn, K. C.; Martello, S. E.; Menon, V. K.; Britto, L. S.; Simmons, K. K.; Mohamed, Y. K.; Ivanova, Y. I.; Ghelmansaraei, A. A.; Weidenbach, S. A.; Zhu, T.; Krystofiak, E.; Young, J. D.; Gama, V.; Rafat, M.

10.1101/2022.05.17.492249 — cancer biology — Posted on 2025-04-23

1482 In vivo assessment of kinematic relationships for epithelial morphogenesis

Namba, T.; Sugimura, K.; Ishihara, S.

10.1101/2025.02.11.637562 — biophysics — Posted on 2025-04-23

1483 Panalyze: automated virus pangenome variation graph construction and analysis

Tennakoon, C.; Freville, T.; Downing, T.

10.1101/2025.04.10.646565 — bioinformatics — Posted on 2025-04-23

1484 X-CRISP: Domain-Adaptable and Interpretable CRISPR Repair Outcome Prediction

Seale, C.; Goncalves, J. P.

10.1101/2025.02.06.636858 — bioinformatics — Posted on 2025-04-23

1485 Self-supervised learning enables unbiased patient characterization from multiplexed cancer tissue microscopy images

Atarsaikhan, G.; Mogollon, I.; Valimaki, K.; iCAN, ; Mirtti, T.; Pellinen, T.; Paavolainen, L.

10.1101/2025.03.05.640729 — bioinformatics — Posted on 2025-04-23

1486 Graph Autoencoder and StrNN based Causal Analysis of Mortality in Heart Failure Patients

Kim, D.

10.1101/2024.11.11.622921 — bioengineering — Posted on 2025-04-23

1487 Social Context Restructures Behavioral Syntax in Mice

Ritter, M.; Shipley, H.; Deiana, S.; Hengerer, B.; Wotjak, C. T.; Brecht, M.; Bogadhi, A. R.

10.1101/2025.04.17.648924 — animal behavior and cognition — Posted on 2025-04-23

1488 Tahoe-100M: A Giga-Scale Single-Cell Perturbation Atlas for Context-Dependent Gene Function and Cellular Modeling

Zhang, J.; Ubas, A. A.; de Borja, R.; Svensson, V.; Thomas, N.; Thakar, N.; Winters, A.; Khan, U.; Jones, M. G.; Tran, V.; Pangallo, J.; Papalexi, E.; Sapre, A.; Nguyen, H.; Sanderson, O.; Nigos, M.; Kaplan, O.; Schroeder, S.; Hariadi, B.; Marrujo, S.; Salvino, C. C. A.; Gallareta Olivares, G.; Koehler, R.; Geiss, G.; Rosenberg, A.; Roco, C.; Merico, D.; Alidoust, N.; Goodarzi, H.; Yu, J.

10.1101/2025.02.20.639398 — genomics — Posted on 2025-04-23

1489 Gene flow can reveal ghost lineages

Tricou, T.; Marsot, E.; Boussau, B.; Tannier, E.; de Vienne, D. M.

10.1101/2024.12.11.627931 — evolutionary biology — Posted on 2025-04-23

1490 Sweeps in space: leveraging geographic data to identify beneficial alleles in Anopheles gambiae

Rehmann, C. T.; Small, S. T.; Ralph, P. L.; Kern, A. D.

10.1101/2025.02.07.637123 — evolutionary biology — Posted on 2025-04-23

1491 Primary and secondary microplastics do not affect hatching of Japanese flounder eggs

Azmi, S. S.; Seong, T.; Kim, H.-J.; Nakatani, H.; Kyozuka, Y.; Asakura, H.; Shimizu, K.; Yagi, M.

10.1101/2025.04.15.648670 — developmental biology — Posted on 2025-04-23

1492 Core splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4

Bonnal, S.; Bajew, S.; Corral, R. M.; Irimia, M.

10.1101/2024.09.17.613571 — molecular biology — Posted on 2025-04-23

1493 SARS-CoV-2 nsp16 is regulated by host E3 ubiquitin ligases, UBR5 and MARCHF7

Tian, L.; Zhao, Z.; Gao, W.; Liu, Z.; Li, X.; Zhang, W.; Li, Z.

10.1101/2024.08.30.610469 — microbiology — Posted on 2025-04-23

1494 Maternal Transfer of Oral Vaccine Induced Anti-OspA Antibodies Protects Peromyscus spp Pups from Tick-Transmitted Borrelia burgdorferi

Azevedo, J. F.; Joyner, G.; Kundu, S.; Samanta, K.; Gomes-Solecki, M.

10.1101/2025.02.24.639966 — microbiology — Posted on 2025-04-23

1495 Origins and evolutionary trajectories of morbilliviruses in Neotropical bats

Jo, W. K.; Moreira-Soto, A.; Campos, A. A.; Goes, L. G. B.; Mares-Guia, M. A.; Rasche, A.; Bispo de Filippis, A.; Hernandez-Mora, G.; Nambulli, S.; Streicker, D.; Duprex, W. P.; Drexler, J. F.; bat morbillivirus consortium,

10.1101/2025.03.18.643905 — microbiology — Posted on 2025-04-23

1496 Enhancement and validation of the antibiotic resistance prediction performance of a cloud-based genetics processing platform for Mycobacteria

Westhead, J.; Baker, C. S.; Brouard, M.; Colpus, M.; Constantinides, B.; Hall, A.; Knaggs, J.; Lopes Alves, M.; Spies, R.; Thai, H.; Surrall, S.; Govender, K.; Peto, T. E.; Crook, D. W.; Omar, S. V.; Turner, R.; Fowler, P. W.

10.1101/2024.11.08.622466 — microbiology — Posted on 2025-04-23

1497 Synthetic community Hi-C benchmarking provides a baseline for virus-host inferences

Shatadru, R. N.; Solonenko, N. E.; Sun, C. L.; Sullivan, M. B.

10.1101/2025.02.12.637985 — microbiology — Posted on 2025-04-23

1498 scRNA+TCR-seq Reveals the Proportion and Characteristics of Dual TCR Treg Cells in Mouse Lymphoid and Non-lymphoid Tissues

Xu, Y.; Peng, Q.; Lu, P. X.; Ma, L.; Li, J.; Yao, X.

10.1101/2024.12.30.630731 — immunology — Posted on 2025-04-23

1499 Combinative protein expression of immediate early genesc-Fos, Arc, and Npas4 along aversive- and reward-related neural networks

Arai, M.; Osanai, H.; Snell, C. C.; Kitamura, T.; Ogawa, S. K.

10.1101/2025.04.21.649441 — neuroscience — Posted on 2025-04-23

1500 An estimate of the longitudinal pace of aging from a single brain scan predicts dementia conversion, morbidity, and mortality

Whitman, E. T.; Elliott, M. L.; Knodt, A. R.; Abraham, W. C.; Anderson, T. J.; Cutfield, N.; Hogan, S.; Ireland, D.; Melzer, T. R.; Ramrakha, S.; Sugden, K.; Theodore, R.; Williams, B. S.; Caspi, A.; Moffitt, T. E.; Hariri, A. R.; Alzheimer's Disease Neuroimaging Initiative,

10.1101/2024.08.19.608305 — neuroscience — Posted on 2025-04-23

1501 Deriving connectivity from spiking activity in detailed models of large-scale cortical microcircuits

Moghbel, F.; Hassan, M. T.; Guet-McCreight, A.; Yao, H. K.; Hay, E.

10.1101/2024.06.13.598937 — neuroscience — Posted on 2025-04-23

1502 Otoacoustic emissions but not behavioral measurements predict cochlear-nerve frequency tuning in an avian vocal-communication specialist

Karosas, D. M.; Gonzales, L.; Wang, Y.; Bergevin, C.; Carney, L. H.; Henry, K. S.

10.1101/2024.08.29.610326 — neuroscience — Posted on 2025-04-23

1503 Predicting Early Transitions in Respiratory Virus Infections via Critical Transient Gene Interactions

Lyu, C.; Jiang, A.; Ng, K. H.; Liu, X.; Chen, L.

10.1101/2025.04.18.649619 — bioinformatics — Posted on 2025-04-23

1504 Benchmarking AlphaFold3-like Methods for Protein-Peptide Complex Prediction

Zhou, F.; Guo, S.; Peng, X.; Zhang, S.; Men, C.; Duan, X.; Zhu, G.; Wang, Z.; Li, W.; Mu, Y.; Zheng, L.; Liu, H.; Wang, S.

10.1101/2025.03.09.642277 — bioinformatics — Posted on 2025-04-23

1505 Multimodal control of Cas13 activity through domain insertion at an allosteric hotspot

Zhu, L.; Nguyen, L. T.; Bell, A. G.; Gillmann, K. M.; Oatman, H.; Hariri, J.; Myhrvold, C.; Toettcher, J. E.

10.1101/2025.04.21.649818 — bioengineering — Posted on 2025-04-23

1506 A Low-Cost Markerless motion capture system to automate Functional Gait Assessment: Feasibility Study

Darici, O.; Cabak, C.; Wong, J. D.

10.1101/2024.12.17.628985 — bioengineering — Posted on 2025-04-23

1507 The abundance of potential B12 producers in gut microbiome is inversely associated with serum vitamin B12 levels: A putative role of Host-microbiome feedback regulation

Chandel, N.; Patel, P.; Somvanshi, P. R.; Verma, A. K.; Thakur, V.

10.1101/2025.04.21.649764 — genomics — Posted on 2025-04-23

1508 Pollen Diet and Sterol Provisioning Differentially Affected Larval Development in a Generalist Solitary Bee

Martel, C.; Kreidt, J.; Furse, S.; Jennifer Scott, J.; Griffiths-Lee, J.; Wright, G. A.; Stevenson, P. C.

10.1101/2025.04.21.649687 — developmental biology — Posted on 2025-04-23

1509 A Dynamic Threshold-Based Method for Robust and Accurate Blink Detection in Eye-Tracking Data

Khodami, M. A.

10.1101/2025.04.21.649751 — neuroscience — Posted on 2025-04-23

1510 Decisional reference point pathology: a mechanism and marker for major depressive disorder in humans

Vittala, A.; Wu, L.; Yan, D.; Liebers, D.; Tell, E.; Song, X.; Dashti, D.; Louie, K.; Raio, C.; Iosifescu, D. V.; Glimcher, P.

10.1101/2025.04.18.649538 — neuroscience — Posted on 2025-04-23

1511 WITHDRAWN: SARS-CoV-2 invades cognitive centers of the brain and induces Alzheimer's-like neuropathology

Shen, W.-B.; Elahi, M.; Logue, J.; Yang, P.; Baracco, L.; Reece, E. A.; Wang, B.; Li, L.; Blanchard, T.; Han, Z.; Frieman, M.; Rissman, R. A.; Yang, P.

10.1101/2022.01.31.478476 — neuroscience — Posted on 2025-04-23

1512 A surprising link between cognitive maps, successor-relation based reinforcement learning, and BTSP

Yang, Y.; Stoeckl, C.; Maass, W.

10.1101/2025.04.22.650046 — neuroscience — Posted on 2025-04-23

1513 Altered auditory maturation in Fragile X syndrome and its involvement in audiogenic seizure susceptibility

Möhrle, D.; Ma, D.; Xue, W.; Yan, J.; Cheng, N.

10.1101/2025.04.22.650065 — neuroscience — Posted on 2025-04-23

1514 TFEB and TFE3 have cell-type specific expression in the brain and divergent roles in neurons

McGuinness, W.; Ryan, B. J.; Guardado, C. L.; Carling, P.; Vallin, B.; Caiazza, M. C.; Heon-Roberts, R.; Kilfeather, P.; Wantling, J.; Hoffmann, J.; Aird, D.; Lofstromm, K.; Zhang, M.; Cowley, S. A.; Hirst, W. D.; Wade-Martins, R.

10.1101/2025.04.22.649949 — cell biology — Posted on 2025-04-23

1515 Auditory Brainstem Development in Autism: From Childhood Hypo-Responsivity to Adult Hyper-Reactivity

Seif, A. A.; Guerville, R.; Rajab, M. S.; Marceau-Linhares, C.; Schaaf, K.; Schmid, S.; Stevenson, R. A.

10.1101/2025.04.22.650041 — neuroscience — Posted on 2025-04-23

1516 Programmatic design and editing of cis-regulatory elements

Schreiber, J.; Lorbeer, F. K.; Heinzl, M.; Lu, Y.; Stark, A.; Noble, W. S.

10.1101/2025.04.22.650035 — bioinformatics — Posted on 2025-04-23

1517 Enhancement of hidden Markov model analyses for improved inference of archaic introgression in modern humans

Coll Macia, M.; Skov, L.; Baek, Z. E. D.; Hobolth, A.

10.1101/2025.04.22.649993 — evolutionary biology — Posted on 2025-04-23

1518 Synaptic Encoding of Time in Working Memory

Mongillo, G.; Misha Tsodyks, M.

10.1101/2025.04.21.649874 — neuroscience — Posted on 2025-04-23

1519 Transcriptomes of higher order thalamic nuclei in obsessive compulsive disorder

Springer, S.; Deshmukh, R.; Klei, L.; Devlin, B.; Glausier, J. R.; Lewis, D. A.; Ahmari, S.

10.1101/2025.04.22.650032 — neuroscience — Posted on 2025-04-23

1520 Face-, color-, and word-specific patches in the human orbitofrontal cortex

Liu, J.; Cohen, L.; Zhan, M.; Bartolomeo, P.

10.1101/2025.04.22.650059 — neuroscience — Posted on 2025-04-23

1521 Generative prediction of causal gene sets responsible for complex traits

Kuznets-Speck, B.; Ogonor, B.; Wytock, T. P.; Motter, A. E.

10.1101/2025.04.17.649405 — bioinformatics — Posted on 2025-04-22

1522 Genomics of freshwater adaptation in three-spine stickleback from eastern Canada

Garcia-Elfring, A.; Salamon, M.; Paccard, A.; Barrett, R. D. H.

10.1101/2025.04.18.649616 — genomics — Posted on 2025-04-22

1523 Pennycress (Thlaspi arvense L.) Seed Persistence in the Field After Two Years

Phippen, W.; Phippen, M. E.; Wesley, T. L.

10.1101/2025.04.18.649506 — genetics — Posted on 2025-04-22

1524 Functional and phylogenetic analysis of placozoan GPCRs reveal the prebilaterian origin of monoaminergic signalling.

Yanez-Guerra, L. A.; Mayorova, T. D.; Guan, L.; Jekely, G.; Wijnen, H.; Senatore, A.

10.1101/2025.04.18.649542 — evolutionary biology — Posted on 2025-04-22

1525 Soil sanctuaries: Experimental manipulations enhance ground-nesting bee habitat across an urban gradient

Fredenburg, A.; Goodell, K.

10.1101/2025.04.18.649528 — ecology — Posted on 2025-04-22

1526 A General Framework for Predicting the Temperature-Dependence of Microbial Interactions

Duan, Q.; Harcombe, W. R.; Savage, V.; Mustri, M. P.; Smith, T. P.; Pawar, S.

10.1101/2025.04.18.649480 — ecology — Posted on 2025-04-22

1527 Are all waterholes equal from a lion's view? Exploring the role of prey abundance and catchability in waterhole visitation patterns in a savannah ecosystem

Dejeante, R.; Loveridge, A. J.; Macdonald, D. W.; Madhlamoto, D.; Chamaille-Jammes, S.; Valeix, M.

10.1101/2025.04.18.649579 — ecology — Posted on 2025-04-22

1528 At the Southern Limit: The Arenal Central Site and the Guarani Occupation of the Parana Delta (Argentina)

Loponte, D.; Carbonera, M.; Schneider, F.; Galarce Machado, N.; Bertoncello, A.; Telles Szczygel, M.; Acosta, A.; Mazza, B.; Sheila, A.; Capparelli, I.

10.1101/2025.04.21.648367 — zoology — Posted on 2025-04-22

1529 Spatial proteomics with 100+ markers with Highly Multiplexed MALDI-IHC

Zhang, M.; Abbey, J. A.; Bost, P.; Usui, G.; Haefliger, S.; Muenst, S.; Lim, M. J.; Yagnik, G. B.; De Souza, N.; Rothschild, K. J.; Bodenmiller, B.

10.1101/2025.04.18.649415 — systems biology — Posted on 2025-04-22

1530 Single Nuclei-Derived Molecular Subtypes of Gastrointestinal Stromal Tumors Correlate with Clinicopathologic Features and Predict Clinical Outcomes

Sharma, A. K.; Wenzel, A. T.; Jun, J.; Guragain, D.; Tang, C.-M.; Antkowiak, M.; Bhargava, S.; Burgoyne, A. M.; Fanta, P.; Munter, S. E.; Chen, K. Y.; Doherty, T. M.; Murugesan, M.; Sanchez-Fernandez, A.; Malli, S.; Mundi, P. S.; Rothschild, S.; Evans, D.; Kim, W.; Schwartz, G. K.; Califano, A.; Tamayo, P.; Mesirov, J. P.; Sicklick, J. K.

10.1101/2025.04.21.647322 — cancer biology — Posted on 2025-04-22

1531 Rare-variant aggregate association analysis using imputed data is a powerful approach.

Liu, T.; Auer, P. L.; Wang, G. T.; Naderi, E.; DeWan, A. T.; Leal, S. M.

10.1101/2025.04.17.649394 — bioinformatics — Posted on 2025-04-22

1532 Discovery of RNA-Reactive Small Molecules Guides Design of Electrophilic Modules for RNA-Specific Covalent Binders

Springer, N. A.; Zanon, P. R. A.; Taghavi, A.; Sung, K.; Disney, M. D.

10.1101/2025.04.22.649986 — biochemistry — Posted on 2025-04-22

1533 First evidence for widespread sharing of stereotyped non-signature whistle types by wild dolphins

Sayigh, L.; Jensen, F.; McHugh, K.; Casoli, M.; Lemercier, L.; Tyack, P.; Wells, R.; Janik, V.

10.1101/2025.04.21.647658 — animal behavior and cognition — Posted on 2025-04-22

1534 Timing of independence is explained by movement ability, but depends on how independence is defined for a long-lived raptor

Bronnvik, H.; Scacco, M.; Chimento, M.; Bassi, E.; Hatzl, J. S.; Sumasgutner, P.; Tschumi, M.; Wikelski, M.; Zimmermann, S.; Safi, K.; Nourani, E.

10.1101/2025.04.21.649390 — animal behavior and cognition — Posted on 2025-04-22

1535 eDNA metabarcoding and whole genome sequencing detect European-American Eel hybrids in northeastern Canada

Crowley, S.; Kess, T.; Bentzen, P.; Neville, V.; Bloom, C.; Smith, N.; Fahner, N.; Berghuis, L.; Hobrecker, K.; Hajibabaei, M.; Duffy, S.; Bradbury, I.

10.1101/2025.04.21.649106 — genomics — Posted on 2025-04-22

1536 Stepwise recombination suppression around the mating-type locus associated with a diploid-like life cycle in Schizothecium fungi

De Filippo, E.; Chahine, E.; Legendre--Despas, J.; Snirc, A.; Labat, A.; Michel, P.; Grognet, P.; Gautier, V.; Levert, E.; Lalanne, C.; Silar, P.; Giraud, T.; Hartmann, F. E.

10.1101/2025.04.18.645578 — evolutionary biology — Posted on 2025-04-22

1537 Fluctuating selection breaks Hamilton's rule for the evolution of altruism

Zhang, F.; Hastings, A.; Hui, C.

10.1101/2025.04.18.649474 — evolutionary biology — Posted on 2025-04-22

1538 When discrete characters are wanting: Continuous character integration under the phylospecies concept informs the revision of the Australian land snail Thersites (Eupulmonata, Camaenidae)

Zhang, G.; Cassis, G.; Koehler, F.

10.1101/2025.04.17.649343 — evolutionary biology — Posted on 2025-04-22

1539 Discrete genetic modules underlie divergent reproductive strategies in three-spined stickleback

Behrens, C.; Tucker, M. E.; Julkowski, K.; Bell, A. M.

10.1101/2025.04.17.649467 — evolutionary biology — Posted on 2025-04-22

1540 A decomposition of a phylogenetically-informed distance into basal and terminal components

Fukuyama, J.

10.1101/2025.04.17.649379 — ecology — Posted on 2025-04-22

1541 Cluster dispersal shapes microbial diversity during community assembly

Marrec, L.; Lehtinen, S.

10.1101/2025.04.17.649399 — ecology — Posted on 2025-04-22

1542 Long-term laboratory Drosophila populations prefer ancestral nutritional cues from the environment

Simoes, P.; Antunes, M. A.; Matos, M.

10.1101/2025.04.17.649384 — ecology — Posted on 2025-04-22

1543 Distribution and efficacy of ingested dsRNA targeting tissue-specific genes in the Argentine ant, Linepithema humile

Dittmann, M.; Buczkowski, G.; Harpur, B.

10.1101/2025.04.22.649969 — molecular biology — Posted on 2025-04-22

1544 Entamoeba histolytica Gal/GalNAc lectin intermediate subunit promotes inflammation and epithelial damage in intestinal amebiasis through its C3 region.

Zhang, H.; Pan, S.; Feng, M.; Dong, D.; Zhao, Y.; Zhou, R.; Li, W.; Cheng, X.

10.1101/2025.04.22.649943 — microbiology — Posted on 2025-04-22

1545 Simultaneous measurements of translation rate and transcriptome in single bacterial cells by scTR-seq uncovers linked regulation within a specialized active cell population.

Baumann, C.; Hydorn, M.; Cooke, S. F.; Dworkin, J.; Rosenthal, A.

10.1101/2025.04.22.649982 — microbiology — Posted on 2025-04-22

1546 Microbiota-derived secondary bile acids promote STING activation and antitumor activity

Yang, X.; Zhang, X.; Li, W.; Gharpure, A.; Hansel-Harris, A.; Tillack, A. F.; Wu, C.; Hsieh, Y.-Z.; Sulpizio, A.; Dikiy, S.; Zhao, X.; Forli, S.; Lairson, L.; Ward, A.; Parker, C. G.; Hang, H.

10.1101/2025.04.16.649255 — immunology — Posted on 2025-04-22

1547 Bioprospection of culturable soil-borne bacteria with biotechnological potential for use in priming defense

Gonzalez - Arriagada, M.; Ortega, J.; Torres, J.; Sulbaran, Y.; Flores, S.; Bastidas, B.; Montero-Morales, P.; Aceituno-Valenzuela, U.; Alvarez, A.; Contreras-Soto, R.; San Blas, E.; Latorre, M.; Pizarro, L.

10.1101/2025.04.21.649657 — immunology — Posted on 2025-04-22

1548 Wearable, High-Density, Time-Domain Diffuse Optical Tomography Array for Functional Neuroimaging

Renehan, K.; Kim, J.; Yin, H.; Wang, F.; Petridis, P. D.; Grinband, J.; Kim, S. H.; Hielscher, A. H.; Shepard, K.

10.1101/2025.04.22.649003 — neuroscience — Posted on 2025-04-22

1549 YOTO (You Only Think Once): A Human EEG Dataset for Multisensory Perception and Mental Imagery

Chang, Y.-H.; Chen, H.-A.; Tsai, M.-J.; Tseng, C.-L.; Lo, C.-H.; Huang, K.-C.; Wei, C.-S.

10.1101/2025.04.17.645384 — neuroscience — Posted on 2025-04-22

1550 Semaglutide, Tirzepatide, and Retatrutide Attenuate the Interoceptive Effects of Alcohol in Male and Female Rats

Windram, M.; Lovelock, D. F.; Carew, J. M.; Krieman, C. G.; Hendershot, C. S.; Besheer, J.

10.1101/2025.04.17.649402 — neuroscience — Posted on 2025-04-22

1551 How Acting Jointly Differs from Acting Side-by-Side: A Dual EEG Study

Fanghella, M.; Mussini, E.; Zazio, A.; Genovese, F.; Satta, E.; Barchiesi, G.; Battaglia Mayer, A.; Bortoletto, M.; Sinigaglia, C.

10.1101/2025.04.18.649548 — neuroscience — Posted on 2025-04-22

1552 Rif-seq reveals Caulobacter crescentus mRNA decay is globally coordinated with transcription and translation

Kulathungage, H.; Aretakis, J. R.; Vaidya, K.; Al-Husini, N.; Muthunayake, N. S.; Kim, S.; Schrader, J. M.

10.1101/2025.04.22.648521 — systems biology — Posted on 2025-04-22

1553 Titin cleavage is a driver of cardiomyocyte disengagement and reactive myocardial fibrosis

Lopez-Unzu, M. A.; Pricolo, M. R.; Silva-Rojas, R.; Clemente-Manteca, A.; Sanchez-Ortiz, D.; Vicente, N.; Velazquez-Carreras, D.; Morales, C.; Gavilan-Herrera, M.; Sen-Martin, L.; Fernandez-Trasancos, A.; Labrador-Cantarero, V.; Sanchez-Garcia, L.; Relano-Ruperez, C.; Sanchez-Cabo, F.; Lalaguna, L.; Isern, J.; Munoz-Canoves, P.; Sabio, G.; Lara-Pezzi, E.; Herrero-Galan, E.; Alegre-Cebollada, J.

10.1101/2025.04.22.645683 — physiology — Posted on 2025-04-22

1554 Preliminary analysis of the metabolic and physical activity profiles of mice lacking the slc43a3-encoded equilibrative nucleobase transporter 1

Sayler, A. L.; Hammond, J. R.

10.1101/2025.04.17.649357 — physiology — Posted on 2025-04-22

1555 Molecular and Epigenetic Pathways Underlying Epithelial Damage and Repair in Necrotizing Enterocolitis via Multi-omics Approach

Xiong, Y.; Zito, A.; Liang, H.; Biouss, G.; Yang, J.; Balsamo, F.; Yeganeh, M.; Lee, C.; Lee, D.; Wang, C.-Y.; Tahmasian, N.; Huang, J.; Minich, A.; Feizi, M.; Wang, S.; Tian, Y.; De Coppi, P.; Kalish, B.; Olguin, P. D.; Zhu, H.; Li, B.; Pierro, A.

10.1101/2025.04.17.647851 — pathology — Posted on 2025-04-22

1556 Tumor Landscape Analysis: An Ecologically Informed Framework to Understand Tumor Microenvironments

Cisneros, L.; Toruner, M. D.; Fernandez-Zapico, M. E.; Maley, C. C.; Carr, R. M.

10.1101/2025.04.22.646608 — cancer biology — Posted on 2025-04-22

1557 Refractive index as an indicator for dynamic protein condensation in cell nuclei

Marin, O.; Kirchweger, P.; Dalaloyan, A.; Barak, Y.; Elbaum, M.

10.1101/2025.04.18.647244 — biophysics — Posted on 2025-04-22

1558 Molecular Basis of EWS Interdomain Self-Association and Its Role in Condensate Formation

Sohn, E. J.; Sojitra, K. A.; Rodrigues, L.; Xu, X.; Frost, B.; Mittal, J.; Libich, D. S.

10.1101/2025.04.16.649245 — biophysics — Posted on 2025-04-22

1559 Detecting cell-level transcriptomic changes of Perturb-seq using Contrastive Fine-tuning of Single-Cell Foundation Models

Zhao, W.; Solaguren-Beascoa, A.; Neilson, G.; Reynolds, R.; Muhammed, L.; Laaniste, L.; Cakiroglu, S. A.

10.1101/2025.04.17.649395 — bioinformatics — Posted on 2025-04-22

1560 DESeq2-MultiBatch: Batch Correction for Multi-Factorial RNA-seq Experiments

Roy, J.; Monthony, A. S.; Torkamaneh, D.

10.1101/2025.04.20.649392 — bioinformatics — Posted on 2025-04-22

1561 Multi-modal single-cell foundation models via dynamic token adaptation

Zhao, W.; Solaguren-Beascoa, A.; Neilson, G.; Muhammed, L.; Laaniste, L.; Cakiroglu, S. A.

10.1101/2025.04.17.649387 — bioinformatics — Posted on 2025-04-22

1562 scRegulate: Single-Cell Regulatory-Embedded Variational Inference of Transcription Factor Activity from Gene Expression

Zandigohar, M.; Rehman, J.; Dai, Y.

10.1101/2025.04.17.649372 — bioinformatics — Posted on 2025-04-22

1563 Microbubble Backscattering Intensity Improves the Sensitivity of Three-dimensional (3D) Functional Ultrasound Localization Microscopy (fULM)

You, Q.; Shin, Y.; Wang, Y.; Lowerison, M.; Lin, B.-Z.; Song, P.

10.1101/2025.04.16.649234 — bioengineering — Posted on 2025-04-22

1564 Engineering patient-derived organotypic bone models for skeletal disease and osteoanabolic therapy testing

de Leeuw, A.; Steffi, C.; Schädli, G. N.; Singh, A.; Lim, P. J.; Rohrbach, M.; Giunta, C.; Rüger, M.; Müller, R.

10.1101/2025.04.17.649276 — bioengineering — Posted on 2025-04-22

1565 Genetic mapping of resistance: A QTL and associated polymorphism conferring resistance to alpha-cypermethrin in Anopheles funestus

AL-Yazeedi, T.; DJUIFO, G.; Leon, M. J.; Muhammad, A.; Hearn, J.; Wondji, C. S.

10.1101/2025.04.16.649184 — genomics — Posted on 2025-04-22

1566 BTRR complex deficiency is a driver for genomic instability in Bloom syndrome

Gönenc, I. I.; Wolff, A.; Busley, A. V.; Wieland, A.; Tijhuis, A.; Müller, C.; Wardenaar, R.; Argyriou, L.; Kaulfuss, S.; Räschle, M.; Spierings, D. C. J.; Foijer, F.; Bastians, H.; Yigit, G.; Zibat, A.; Cyganek, L.; Wollnik, B.

10.1101/2025.04.17.649287 — genetics — Posted on 2025-04-22

1567 The PERPETUAL FLOWERING Locus: Necessary But Insufficient for Genomic Prediction of Runnerless and Other Asexual Reproduction Phenotypes in Strawberry

Brukental, H.; Bjornson, M. L.; Pincot, D. D. A.; Hardigan, M. A.; Sharma, S.; Jimenez, N. P.; Famula, R. A.; Lopez Ramirez, C. M.; Cole, G. S.; Feldmann, M. J.; Knapp, S. J.

10.1101/2025.04.20.646347 — genetics — Posted on 2025-04-22

1568 μSeq: Universal mutation rate quantification via deep sequencing of a single clonal expansion.

Pompei, S.; Geroldi, A.; Rivetti, P.; Grassi, E.; Vurchio, V.; Tallarico, G.; Corti, G.; Tattini, L.; Liti, G.; Bertotti, A.; Cosentino Lagomarsino, M.

10.1101/2025.04.17.649315 — evolutionary biology — Posted on 2025-04-22

1569 Enhancing Evolutionary Timelines: The Impact of Stratigraphic Range Information on Phylogenetic Inference

Stolz, U.; Gavryushkina, A.; Vaughan, T. G.; Stadler, T.; Allen, B. J.

10.1101/2025.04.17.649084 — evolutionary biology — Posted on 2025-04-22

1570 Flight feathers evolve fastest near the tip of the wing

Rader, J. A.; Bradley, E. B.; Petersen, M. E.; Matute, D. R.

10.1101/2025.04.17.649363 — evolutionary biology — Posted on 2025-04-22

1571 The genomic imprint of chromosomal inversions and demographic history in island populations of deer mice

Howell, E. K.; Baier, F.; Hoekstra, H. E.; Payseur, B. A.

10.1101/2025.04.18.649517 — evolutionary biology — Posted on 2025-04-22

1572 Using reciprocally retained gene families to detect whole-genome multiplications in plants

Tasdighian, S.; Sensalari, C.; Maere, S.

10.1101/2025.04.18.649489 — evolutionary biology — Posted on 2025-04-22

1573 Compartmentalization of mRNA and Translation by Desmosomes

D'Alessandro, A.; Badu-Nkansah, K.; Link, S.; Hlavaty, D.; Bjerke, G.; Nicchitta, C. V.; Yi, R.; Lechler, T.

10.1101/2025.04.17.649424 — cell biology — Posted on 2025-04-22

1574 RF-SIRF defining reversed DNA replication forks with single-cell and spatio-temporal resolution reveals a replication stress specific epigenetic code

Roy, S.; Firmreite, M.; Citron, F.; Draetta, G.; Schlacher, K.

10.1101/2025.04.21.649830 — molecular biology — Posted on 2025-04-22

1575 Mouse digit AAV gene delivery into fibroblasts regulates regenerative outcome

Jou, V.; Semelsberger, S. D.; Smerczynski, J.; Lehoczky, J. A.

10.1101/2025.04.22.650049 — molecular biology — Posted on 2025-04-22

1576 Structures of human organellar SPFH protein complexes

Gao, J.; Sherpa, D.; Kupko, N.; Shao, S.

10.1101/2025.04.21.649849 — molecular biology — Posted on 2025-04-22

1577 Impact of the RaS-RiPP tryglysin and culturing conditions on ex-vivo oral microbiomes.

Rued, B. E.; Dhariwal, A.; Covington, B. C.; Seyedsayamdost, M. R.; Krivograd, S. A.; Pesavento, R. P.; Federle, M. J.; Petersen, F. C.

10.1101/2025.04.21.649776 — microbiology — Posted on 2025-04-22

1578 Vibrio cholerae colonization of the arthropod intestine activates innate immune signaling in enteroendocrine cells via phosphorylation of the nuclear receptor ultraspiracle

Ding, X.; Watnick, P.

10.1101/2025.04.21.649885 — microbiology — Posted on 2025-04-22

1579 Piromyces struthionis, sp. nov., a new anaerobic gut fungus from the feces of ostriches

Nash, K.; Vinzelj, J.; Pratt, C.; Elshahed, M.; Youssef, N. H.

10.1101/2025.04.22.650011 — microbiology — Posted on 2025-04-22

1580 A pbpB1 mutation causing β-lactam resistance in clinical Listeria monocytogenes isolates

Wamp, S.; Wagner, R.; Schuler, F.; Kruettgen, A.; Flieger, A.; Halbedel, S.

10.1101/2025.04.22.649998 — microbiology — Posted on 2025-04-22

1581 TlyA is a 23S and 16S 2'-O-methylcytidine methyltransferase important for ribosome assembly in Bacillus subtilis

Hibma, J. L.; Munson, L. M.; Jones, J. D.; Nye, T. M.; Koutmou, K. S.; Simmons, L. A.

10.1101/2025.04.21.649808 — microbiology — Posted on 2025-04-22

1582 Contributions of β-lactamase substrate specificity and outer membrane permeability to the antibiotic sheltering of β-lactam-susceptible bacteria

Lohans, C. T.; Jeffs, M.; Mora Ochomogo, M.; Liu, J. L.

10.1101/2025.04.22.649001 — microbiology — Posted on 2025-04-22

1583 Neutrophils respond with pathogen-specific defenses during bacterial pneumonia

Pihl, R.; Martins, K.; Lee, Y.; Patneaude, L.; Quinton, L.; Mizgerd, J.; Belkina, A.; Traber, K.

10.1101/2025.04.17.649365 — immunology — Posted on 2025-04-22

1584 On-Body Measure of Reaction Time Correlates With Intoxication Level

Blackwell, M.; Valk, H.; Eaton, J.; Kovaly, S.; Karnes, S.; Vu, T.; Stevenson, K.; Kowalczyk, M.; Gormley, W. B.

10.1101/2025.04.17.649358 — neuroscience — Posted on 2025-04-22

1585 Region-specific mechanosensation in Drosophila postural control behaviour

Roseby, W.; Menzies, J. A. C.; Lipscomb, V. A.; Alonso, C. R.

10.1101/2025.04.22.645758 — neuroscience — Posted on 2025-04-22

1586 Charting the transition from in vitro gliogenesis to the in vivo maturation of transplanted human glial progenitor cells

Mariani, J. N.; Schanz, S. J.; Mansky, B.; Wei, X.; Long, C. C.; Chandler-Militello, D.; Huynh, N. P. T.; Goldman, S. A.

10.1101/2025.04.22.649367 — neuroscience — Posted on 2025-04-22

1587 Optically detected and radio wave-controlled spin chemistry in cryptochrome

Meng, K.; Nie, L.; Berger, J.; von Grafenstein, N. R.; Einholz, C.; Rizzato, R.; Schleicher, E.; Bucher, D. B.

10.1101/2025.04.16.649006 — biophysics — Posted on 2025-04-22

1588 Improved CRISPR/Cas9 Off-target Prediction with DNABERT and Epigenetic Features

Kimata, K.; Satou, K.

10.1101/2025.04.16.649101 — bioinformatics — Posted on 2025-04-22

1589 AAVs Targeting Human Carbonic Anhydrase IV Enhance Gene Delivery to the Brain

Lin, C.; Chen, X.; Hoang, J. D.; Ristic, F.; Fan, Y.; Jang, S.; Chung, J. H. A.; Sullivan, E. E.; Gawda, T.; Kavvathas, B.; Tran, I.; Li, Y.; Steele, A. D.; Shay, T. F.; Gradinaru, V.

10.1101/2025.04.21.649868 — bioengineering — Posted on 2025-04-22

1590 Real-Time Wide-Field Fluorescence Lifetime Imaging via Single-Snapshot Acquisition for Biomedical Applications

Pandey, V.; Millar, E.; Erbas, I.; Chavez, L. M.; Radford, J.; Crosbourne, I.; Madhusudan, M.; Taylor, G. G.; Yuan, N.; Bruschini, C.; Radev, S. T.; Barroso, M.; Tobin, A. B.; Michalet, X. B.; Charbon, E.; Faccio, D.; Intes, X.

10.1101/2025.04.16.646646 — bioengineering — Posted on 2025-04-22

1591 Development of CRISPR/Cas13-based analytical tools to study RNA-Protein Interactions

Yamamoto, K.; Shikata, S.; Hao, Y.; Tomita, T.; Verhoeyen, E.; Saeki, Y.; Goyama, S.

10.1101/2025.04.22.649962 — bioengineering — Posted on 2025-04-22

1592 Introducing An Argonaute-facilitated Isothermal Amplification Technology

Gao, F.; Han, C.

10.1101/2025.04.21.649904 — biochemistry — Posted on 2025-04-22

1593 Chronobot: Deep learning guided time-resolved cryo-EM captures molecular choreography of RecA in homology search

Mäeots, M.-E.; Tupin, S.; Esfahani, N. M. M.; Molina, J. B. R.; Clapperton, J. A.; Amin, A.; Imbert, A.; Enchev, R. I.

10.1101/2025.04.21.649820 — biochemistry — Posted on 2025-04-22

1594 Structural insight into binding of novel PET tracer MODAG-005 to lipidic ????-Synuclein fibrils

Kim, M.; Matthes, D.; Frieg, B.; Leonov, A.; Ryazanov, S.; Bleher, D.; Grotegerd, A.-K.; Dienemann, C.; Giese, A.; Schröder, G. F.; Becker, S.; Herfert, K.; Groot, B. L. d.; Andreas, L. B.; Griesinger, C.

10.1101/2025.04.21.649837 — biochemistry — Posted on 2025-04-22

1595 Sustained MYB activity drives emergent enhancer activation and precise enhancer-promoter interactions

Lau, I.-J.; Harman, J. R.; Smith, A. L.; Denny, N.; Jackson, N. E.; Hamley, J. C.; Vyas, P.; Davies, J. O. J.; Hughes, J. R.; Crump, N. T.; Milne, T. A.

10.1101/2025.04.16.649256 — genomics — Posted on 2025-04-22

1596 Factors Influencing Emerald Ash Borer Ecological Interactions

Borsato, N. D.; McFarlane, E.; Garrett, N.; Biganzoli-Rangel, A.; Marquina, D.; Steinke, D. R.; Floyd, R.; Clare, E.

10.1101/2025.04.16.649187 — ecology — Posted on 2025-04-22

1597 Do epidemiologically impactful vector control interventions disrupt mosquito population structure?

Dennis, T. P. W.; Guelbeogo, W. M.; Ferguson, H. M.; Lindsay, S.; N'Fale, S.; Pignatell, P.; Ranson, H.; Sanou, A.; Tiono, A.; Weetman, D.; Viana, M.

10.1101/2025.04.16.649034 — ecology — Posted on 2025-04-22

1598 Long-read transcriptome-wide RNA structure maps using DMS-FIRST-seq

Begik, O.; Diensthuber, G.; Borovska, I.; Mattick, J. S.; Incarnato, D.; Novoa, E. M.

10.1101/2025.04.22.649934 — molecular biology — Posted on 2025-04-22

1599 Endothelial Prolyl Hydroxylase 3 Mitigates Maladaptive Inflammation to Promote Post-Ischemic Kidney Repair

Sharma, R.; Tiwari, R.; O'Sullivan, J.; Borkowski, G. S.; An, S. Y.; Thorp, E. B.; Chandel, N. S.; Quaggin, S. E.; Kapitsinou, P. P.

10.1101/2025.04.21.649850 — molecular biology — Posted on 2025-04-22

1600 Synergistic cefiderocol-containing antibiotic combinations active against highly drug-resistant Acinetobacter baumannii patient isolates with diverse resistance mechanisms

Halim, J.; Keane, A. P.; Bouzo, J.; Aderibigbe, T.; Chicola, J. A.; Nolan, K. T.; Jonnalgadda, K.; Tran, J. X.; Carabetta, V.

10.1101/2025.04.22.649919 — microbiology — Posted on 2025-04-22

1601 Particle attachment drives seasonal abundance and photoheterotrophy of marine aerobic anoxygenic phototrophs

Villena-Alemany, C.; Vrdoljak Tomas, A.; Mujakic, I.; Kopejtka, K.; Santic, D.; Koblizek, M.

10.1101/2025.04.22.649935 — microbiology — Posted on 2025-04-22

1602 Adeno-Associated Virus 2 (AAV2) - induced RPA exhaustion generates cellular DNA damage and restricts viral gene expression

Summers, M. F.; Haubold, M. K.; Morgenstern, M.; Shepherd, P.; Larsen, C. I.; Bartz, A. E.; Thirumoorthy, G.; Kirchdoerfer, R. N.; Coon, J. J.; Mehta, K. P.; Majumder, K.

10.1101/2025.04.22.649920 — microbiology — Posted on 2025-04-22

1603 RXR agonist S169 inhibits HBV/HDV entry in vitro by disrupting KIF4-dependent NTCP trafficking.

Gad, S. A.; Hussein, S. A.; Fukano, K.; Kato, T.; Shoji, I.; Chayama, K.; Muramatsu, M.; Isogawa, M.; Wakita, T.; Merk, D.; Aly, H. H.

10.1101/2025.04.21.649881 — microbiology — Posted on 2025-04-22

1604 Molnupiravir inhibits Bourbon virus infection and disease-associated pathology in mice

Bamunuarachchi, G.; Zhao, F.; Bricker, T. L.; Seehra, K.; Karp, A.; Diamond, M.; Boon, A. C.

10.1101/2025.04.21.649883 — microbiology — Posted on 2025-04-22

1605 Single-Cell RNA Sequencing Defines Developmental Progression and Reproductive Transitions of Pneumocystis carinii

Albee, A.; Sayson, S. G.; Ashbaugh, A.; Porollo, A.; Smulian, A. G.; Cushion, M. T.

10.1101/2025.04.21.649879 — microbiology — Posted on 2025-04-22

1606 Quantification and Diagnostic Relevance of Blood and Heme-Mediated Inhibition of Prion Detection by RT-QuIC

Piel, R. B.; Schneider, D. A.

10.1101/2025.04.21.649906 — microbiology — Posted on 2025-04-22

1607 Mathematical modelling of in vitro replication dynamics for multiple highly pathogenic avian influenza clade 2.3.4.4 viruses in chicken and duck cells

Bordes, L.; Hobbelen, P.; Blokker, E.; van der Poel, W. H. M.; Beauchemin, C. A. A.; Beerens, N.; Gonzales, J. L.

10.1101/2025.04.22.649950 — microbiology — Posted on 2025-04-22

1608 CXCL13/CXCR5 Chemokine Axis Promotes CXCR5+CD19+ B-Cell and Follicular/Effector CXCR5+CD4+ T-Cell Responses in the Lungs Associated with Protection from Severe and Fatal COVID-19 Following Infection with Pathogenic SARS-CoV-2 Delta Variant

Vahed, H.; Chentoufi, A.; Prakash, S.; Quadiri, A.; Karan, S.; Lekhbach, Y.; Omorogieva, E.; Patel, S. J.; Tadros, J.; Liao, E. J.; Lau, L. S. L.; Tifrea, D. F.; BENMOHAMED, L.

10.1101/2025.04.18.649623 — immunology — Posted on 2025-04-22

1609 SARS-CoV E protein couples asymmetric leaflet thickness and curvature deformations

Sandberg, J. W.; Brannigan, G.

10.1101/2025.04.18.649534 — biophysics — Posted on 2025-04-22

1610 Antibody escape drives emergence of diverse spike haplotypes resembling variants of concern in persistent SARS-CoV-2 infections

Snell, L. B.; Pickering, S.; Alcolea-Medina, A.; Winstone, H.; Seow, J.; Graham, C.; O'Connell, L.; Batra, R.; Malim, M. H.; Doores, K. J.; Nebbia, G. D.; Edgeworth, J.; Neil, S.; Galao, R. P.

10.1101/2025.04.17.648944 — microbiology — Posted on 2025-04-22

1611 Strengthening Medial Olivocochlear Feedback Reduces the Developmental Impact of Early Noise Exposure

Castagna, V. C.; Boero, L. E.; Di Guilmi, M. N.; Fuchs, P. A.; Lauer, A. M.; Elgoyhen, A. B.; Gomez-Casati, M. E.

10.1101/2025.01.03.631257 — neuroscience — Posted on 2025-04-22

1612 Mapping the spatial architecture of glioblastoma from core to edge delineates niche-specific tumor cell states and intercellular interactions

Khan, S. M.; Wang, A. Z.; Desai, R. R.; McCornack, C. R.; Sun, R.; Dahiya, S. M.; Foltz, J. A.; Sherpa, N. D.; Leavitt, L.; West, T. R.; Wang, A. F.; Krbanjevic, A.; Choi, B. D.; Leuthardt, E. C.; Patel, B.; Charest, A.; Kim, A. H.; Dunn, G. P.; Petti, A. A.

10.1101/2025.04.04.647096 — cancer biology — Posted on 2025-04-22

1613 The systematic assessment of completeness of public metadata accompanying omics studies in the Gene Expression Omnibus

Huang, Y.-N.; Jaiswal, P. V.; Rajesh, A.; Yadav, A.; Yu, D.; Liu, F.; Scheg, G.; Boldirev, G.; Nakashidze, I.; Mehta, J. H.; Wang, K.; Patel, K. K.; Sarkar, A.; Mirza, M. A. B.; Hu, J.; Peng, Q.; Hapani, K. C.; Ayyala, R.; Guo, R.; Wong, M. Y.; Kapur, S.; Ramesh, T.; Abedalthagafi, M. S.; Mangul, S.

10.1101/2021.11.22.469640 — bioinformatics — Posted on 2025-04-22

1614 Dexrazoxane as a viable microsporidia control agent in Anopheles gambiae

Zeferino, T. G.; Silva, L. M.

10.1101/2024.10.14.617874 — ecology — Posted on 2025-04-22

1615 Loss of olfaction reduces caterpillar performance and increases susceptibility to a natural enemy

Wang, Q.; Jia, Y.; Smid, H.; Weldegergis, B.; Greenberg, L.; Jongsma, M.; Dicke, M.; Haverkamp, A.

10.1101/2024.12.17.629055 — ecology — Posted on 2025-04-22

1616 ADMA-histones play a crucial role in the initial recognition of dual-strand piRNA cluster regions by Rhino

Saito, R.; Ishizu, H.; Harigai, R.; Murano, K.; Namba, Y.; Siomi, M. C.

10.1101/2024.03.15.585151 — molecular biology — Posted on 2025-04-22

1617 Spatial integration of sensory input and motor output in Pseudomonas aeruginosa chemotaxis through colocalized distribution

Wu, Z.; Tian, M.; Fu, S.; Chen, M.; Zhang, R.; Yuan, J.

10.1101/2024.03.13.584826 — microbiology — Posted on 2025-04-22

1618 Mind the blank: behavioral, experiential, and physiological signatures of absent-mindedness

Musat, E. M.; LeCoz, A.; Corcoran, A. W.; Belloli, L.; Naccache, L.; Andrillon, T.

10.1101/2024.02.11.579845 — neuroscience — Posted on 2025-04-22

1619 Feedback of peripheral saccade targets to early foveal cortex

Kaemmer, L.; Kroell, L. M.; Knapen, T.; Rolfs, M.; Hebart, M. N.

10.1101/2025.02.20.639262 — neuroscience — Posted on 2025-04-22

1620 Phase consistency dynamics of memory encoding

Colyer, R. A.; Kahana, M. J.

10.1101/2024.12.06.627211 — neuroscience — Posted on 2025-04-22

1621 Increased listening effort and cochlear neural degeneration underlie behavioral deficits in speech perception in noise in normal hearing middle-aged adults.

Zink, M. E.; Zhen, L.; McHaney, J. R.; Klara, J.; Yurasits, K.; Cancel, V.; Flemm, O.; Mitchell, C.; Datta, J.; Chandrasekaran, B.; Parthasarathy, A.

10.1101/2024.08.01.606213 — neuroscience — Posted on 2025-04-22

1622 Inference technique for the synaptic conductances in rhythmically active networks and application to respiratory central pattern generation circuits

Molkov, Y. I.; Borgmann, A.; Koizumi, H.; Hama, N.; Zhang, R.; Smith, J. C.

10.1101/2024.08.12.607656 — neuroscience — Posted on 2025-04-22

1623 An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes

Furlanis, E.; Dai, M.; Leyva Garcia, B.; Tran, T.; Vergara, J.; Pereira, A.; Gorissen, B. L.; Wills, S.; Vlacho, A.; Hairston, A.; Dwivedi, D.; Du, S.; McMahon, J.; Huang, S.; Morabito, A.; Vazquez, A.; Kim, S.; Lee, A. T.; Chang, E. F.; Razzaq, T.; Qazi, A.; Vargish, G.; Yuan, X.; Caccavano, A.; Hunt, S.; Chittajallu, R.; McLean, N.; Hewit, L.; Paranzino, E.; Rice, H.; Cummins, A. C.; Plotnikova, A.; Mohanty, A.; Tangen, A. C.; Shin, J. H.; Azadi, R.; Eldridge, M. A. G.; Alvarez, V. A.; Averbeck, B. B.; Alyahyay, M.; Reyes Vallejo, T.; Soheib, M.; Vattino, L. G.; MacGregor, C. P.; Chatain, C.

10.1101/2024.07.17.603924 — neuroscience — Posted on 2025-04-22

1624 Orexin neurons couple pupil-linked arousal to Agrp hunger neurons to shape adaptive eating and food value perception

Kosar, S.; Bracey, E.; Du, Y.; Peleg-Raibstein, D.; Burdakov, D.

10.1101/2025.03.07.642010 — neuroscience — Posted on 2025-04-22

1625 Investigating the apical notch, apical dominance and meristem re-emergence in Marchantia polymorpha.

Marron, A. O.

10.1101/2024.02.04.575544 — plant biology — Posted on 2025-04-22

1626 Population analysis and immunologic landscape of melanoma in people living with HIV

Barger, L. N.; Wang, D.; Saravia, A.; Mezzano, V.; Ward, G.; Loomis, C.; Feldman, C.; Tuluc, M.; Seedor, R. S.; Gaskill, P. J.; Coghill, A. E.; Suneja, G.; Dehzangi, I.; Hope, J. L.; Jour, G.; Romano, G.

10.1101/2025.04.17.648995 — cancer biology — Posted on 2025-04-22

1627 Expression of a RAS degrader via synthetic nanocarrier-mediated mRNA delivery reduces pancreatic tumors

Escher, T. E.; Yuk, S. A.; Qian, Y.; Qiang, W.; Almunif, S.; Sharma, S.; Scott, E. A.; Satchell, K. J.

10.1101/2024.06.11.598439 — cancer biology — Posted on 2025-04-22

1628 Concatenated Modular BK Channel Constructs Reveal Divergent Stoichiometry in Gating Control by LRRC26 (γ1), Pore, and Selectivity Filter

Chen, G.; Li, Q.; Yan, J.

10.1101/2023.06.26.546634 — biochemistry — Posted on 2025-04-22

1629 Limited Dispersal of Benthic Environmental DNA from a Subtropical Mesophotic Shelf-Edge Bank

McCartin, L. J.; Govindarajan, A. F.; McDermott, J. M.; Herrera, S.

10.1101/2024.08.26.609783 — ecology — Posted on 2025-04-22

1630 Redefining the timing and circumstances of cat domestication, their dispersal trajectories, and the extirpation of European wildcats

Doherty, S.; Krajcarz, M.; Carmagnini, A.; Dimopoulos, E.; Jamieson, A.; Alves, J. M.; Balasescu, A.; Baker, P.; Baranowski, P.; Beglane, F.; Bitz-Thorsen, J.; Bolton, A.; Bowden, W.; Britton, H.; De Cupere, B.; De Martino, M.; Donnelly-Symes, B.; Evin, A.; Fowler, T.; Fulford, M.; Gotfredsen, A. B.; Han, Y.; Kitchener, A. C.; Knapp, Z.; Luo, S.-J.; Mainland, I.; Maricevic, D.; Moody, S.; Nesnidaloa, T.; O'Connor, T.; Orton, D. C.; Peters, J.; Sadebeck, F.; Siegenthaler, A.; Smallman, R.; Suvova, Z.; Symmons, R.; Sudds, J.; Thomas, G.; Van Neer, W.; Wilczynski, J.; Ottoni, C.; Popovic, D.; Fra

10.1101/2025.03.28.645877 — zoology — Posted on 2025-04-22

1631 Integrating population-level and cell-based signatures for drug repositioning

He, C.; Xu, Y.; Zhou, Y.; Fan, J.; Cheng, C.; Meng, R.; Gamazon, E. R.; Zhou, D.; Pan, R.; Wu, L.; Shah, R. V.

10.1101/2023.10.25.564079 — bioinformatics — Posted on 2025-04-22

1632 Facilitating genome annotation using ANNEXA and long-read RNA sequencing

Hoffmann, N.; Besson, A.; Cadieu, E.; Lorthiois, M.; Le Bars, V.; Houel, A.; Hitte, C.; Andre, C.; Hedan, B.; Derrien, T.

10.1101/2025.04.16.648718 — bioinformatics — Posted on 2025-04-22

1633 MemBrain v2: an end-to-end tool for the analysis of membranes in cryo-electron tomography

Lamm, L.; Zufferey, S.; Zhang, H.; Righetto, R. D.; Waltz, F.; Wietrzynski, W.; Yamauchi, K. A.; Burt, A.; Liu, Y.; Martinez-Sanchez, A.; Ziegler, S.; Isensee, F.; Schnabel, J. A.; Engel, B. D.; Peng, T.

10.1101/2024.01.05.574336 — bioinformatics — Posted on 2025-04-22

1634 circDesign Algorithm for Designing Synthetic Circular RNA

Xu, C.; Pu, C.; Chen, R.; Wang, W.; Jiang, F.; Deng, C.; Zhai, D.; Chen, Y.; Hu, W.; Zhang, Y.; Tang, Y.; Wang, Q.; An, J.; Wang, H.; Wu, J.; Wang, X.; Liu, M.; Shen, H.; Huang, L.; Zhong, Z.; Tan, W.; Liu, D.; Zhang, L.

10.1101/2023.07.09.548293 — bioengineering — Posted on 2025-04-22

1635 Discovery of a wide variety of α-1,6-cyclized β-1,2-glucan synthases: a new entrance for host-microbe interactions.

Motouchi, S.; Kim, I.; Ishiguro, A.; Niu, K.; Komba, S.; Kashima, T.; Kitano, Y.; Nakai, H.; Nakajima, M.

10.1101/2025.04.21.649730 — biochemistry — Posted on 2025-04-22

1636 Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zones

Carrington, J. T.; Wilson, R. H.; de La Vega, E.; Thiyagarajan, S.; Barker, T.; Catchpole, L.; Durrant, A.; Knitlhoffer, V.; Watkins, C.; Gharbi, K.; Nieduszynski, C. A.

10.1101/2024.04.28.591325 — genomics — Posted on 2025-04-22

1637 Connectome-based brain fingerprints predict early cognitive decline in Parkinson's patients with minor hallucinations

Stampacchia, S.; Bernasconi, F.; Van De Ville, D.; Amico, E.; Pagonabarraga, J.; Kulisevsky, J.; Blanke, O.

10.1101/2025.04.17.649310 — neuroscience — Posted on 2025-04-22

1638 Mapping Serotonergic Dynamics using Drug-Modulated Molecular Connectivity

Ionescu, T. M.; Amend, M.; Hafiz, R.; Maurer, A.; Biswal, B. B.; Wehrl, H. F.; Herfert, K.

10.1101/2024.02.08.579462 — neuroscience — Posted on 2025-04-22

1639 Proteomic Remodeling During Tumor Cell-Induced Platelet Aggregation Unveils Metastatic Drivers in Colorectal Cancer

Sauer, T.; Gruner, C.; Kern, K.; Rackisch, A.; Tischner, L.; Schulz, K.; Ostermann, J.; Cohrs, L.; Kohl, M.; Verschoor, A.; Gemoll, T.

10.1101/2025.04.09.647951 — cancer biology — Posted on 2025-04-22

1640 PriMAT: A robust multi-animal tracking model for primates in the wild

Vogg, R.; Nuske, M.; Weis, M. A.; Luddecke, T.; Karakoc, E.; Ahmed, Z.; Pereira, S.; Malaivijitnond, S.; Meesawat, S.; Murphy, D.; Fischer, J.; Worgotter, F.; Kappeler, P. M.; Gail, A.; Ostner, J.; Schulke, O.; Fichtel, C.; Ecker, A. S.

10.1101/2024.08.21.607881 — animal behavior and cognition — Posted on 2025-04-22

1641 Access to emotional memories: Evidence for a vagal route to boost memory retrieval using non-invasive taVNS

Giraudier, M.; Ventura-Bort, C.; Weymar, M.

10.1101/2025.04.17.649268 — neuroscience — Posted on 2025-04-22

1642 Inferring domestic goat demographic history through ancient genome imputation

Erven, J. A. M.; Etourneau, A.; Mashkour, M.; Neupane, M.; Bardou, P.; Stella, A.; Talenti, A.; Masiga, C. W.; Van Tassel, C. P.; Clark, E. L.; Pompanon, F.; Colli, L.; Amallis, M.; Milanesi, M.; Crepaldi, P.; Consortium, T. V.; Servin, B.; Rosen, B.; Tosser-Klopp, G.; Daly, K. G.

10.1101/2025.04.18.649576 — genomics — Posted on 2025-04-22

1643 Alternative Splicing Across the Tree of Life: A Comparative Study

de la Fuente, R.; Diaz-Villanueva, W.; Arnau, V.; Moya, A.

10.1101/2023.12.26.571677 — evolutionary biology — Posted on 2025-04-22

1644 Tissue scarring provides a biomechanical framework to promote mammalian bile duct regeneration through the activation of integrin-SRC/FAK signalling.

Walker, A.; Olaizola, P.; Brennan, E.; Jarman, E. J.; Yao, Y.; Carmichael, E.; Gradinaru, A.; Loftus, A. E. P.; Wilson, D. H.; Martinez Lyons, A.; Charlton, L.; Ober-Vliegen, K.; Mi, W.; Broeders, A.; Davies, K.; Carragher, N.; Unciti-Broceta, A.; Kendall, T. J.; J.W. van der Laan, L.; Verstegen, M.; Frame, M. C.; Waddell, S. H.; Boulter, L.

10.1101/2025.04.21.649531 — cell biology — Posted on 2025-04-22

1645 Evaluation of nanopore sequencing for increasing accessibility of eDNA studies in biodiverse countries

Gygax, D.; Ramirez, S.; Chibesa, M.; Simpamba, T.; Riffel, M.; Riffel, T.; Srivathsan, A.; Nijland, R.; Urban, L.

10.1101/2025.04.21.649756 — molecular biology — Posted on 2025-04-22

1646 Function and firing of the Streptomyces coelicolor contractile injection system requires the membrane protein CisA

Casu, B.; Sallmen, J. W.; Haas, P. E.; Chandra, G.; Afanasyev, P.; Xu, J.; Pilhofer, M.; Schlimpert, S.

10.1101/2024.06.25.600559 — microbiology — Posted on 2025-04-22

1647 Early-Life Environmental Exposures Reprogram Epigenomic Aging to Alter Gene Expression Trajectories

Grimm, S. L.; Jangid, R.; Bartolomei, M. S.; Dolinoy, D. C.; Aylor, D. L.; Mutlu, G. M.; Biswal, S.; Zhang, B.; Wang, T.; TaRGET II Consortium, ; Coarfa, C.; Walker, C. L.

10.1101/2025.04.21.649824 — genomics — Posted on 2025-04-22

1648 Embryonic stem cells do not have a globally disrupted higher-order chromatin fibre structure

Gilbert, N.; Boyle, S.; Allan, J.

10.1101/2025.04.22.649930 — molecular biology — Posted on 2025-04-22

1649 BMAL1 and YAP cooperate to hijack enhancers and promote inflammation in the aged epidermis

Bonjoch, J.; Sola, P.; Reina, O.; Mortimer, T.; Miroshnikova, Y. A.; Wickstrom, S.; Stephan-Otto Attolini, C.; Alvarez, L.; Aznar Benitah, S.; Solanas, G.

10.1101/2025.04.22.649967 — molecular biology — Posted on 2025-04-22

1650 Steady-state phosphorylation of SHIP1 by Lyn restricts macrophage activation in the absence of a phagocytic synapse

Senevirathne, S. E.; Kanagy, W. K.; Cattley, R. T.; Swanson, W. L.; Ramos, S. T.; Nunez, M. G.; Hawse, W. F.; Freedman, T. S.

10.1101/2025.04.16.648985 — immunology — Posted on 2025-04-22

1651 Neuropathological hallmarks during the chronic phase of ischemic stroke in mice and humans

Khan, R.; Guzman, G. U.; Do, T. H.; Devlin, P.; Ahn, J. J.; Tan, C.; Venna, V. R.; Marrelli, S. P.; Koochak, H. P.; DiGesu, C.; Flores, A.; McCullough, L. D.; Ritzel, R. M.

10.1101/2025.04.16.649173 — neuroscience — Posted on 2025-04-22

1652 Design of peptide-based PAC1 antagonists combining molecular dynamics simulations and a biologically relevant cell-based assay

Xu, W.; Keith, A. M.; Ye, W.; Hu, X.; Southall, N.; Juan, M. J.; Ferrer, M.; Henderson, M. J.; Sexton, P. M.; Deganutti, G.; Eiden, L. E.

10.1101/2025.04.16.649181 — pharmacology and toxicology — Posted on 2025-04-22

1653 Antimuscarinic drugs exert β-arrestin-biased agonism at the muscarinic acetylcholine type 1 receptor

Amiri, S.; Aghanoori, M.-R.; Smith, D. R.; Waise, T. M. Z.; Lao, Y.; Inoue, A.; Zahedi, R.; Dunn, H. A.; Fernyhough, P.

10.1101/2025.04.16.649213 — pharmacology and toxicology — Posted on 2025-04-22

1654 Spatially aligned random partition models on spatially resolved transcriptomics data

Duan, Y.; Guo, S.; Yan, H.; Wang, W.; Mueller, P.

10.1101/2025.04.16.649218 — bioinformatics — Posted on 2025-04-22

1655 Controlled Release of Bone Morphogenetic Protein-2 Improves Motor Function After Traumatic Brain Injury in a Rat Model

Townsend, J. M.; Deng, J. Z.; Barbay, S.; Andrews, B. T.; Nudo, R. J.; Detamore, M. S.

10.1101/2025.04.16.649206 — bioengineering — Posted on 2025-04-22

1656 Ionic liquid-coated lipid nanoparticles promote enhanced red blood cell hitchhiking

Khare, P.; Edgecomb, S. X.; Hamadani, C. M.; Taylor, G. R.; Caprara, R.; Tanner, E. E. L.; Manickam, D. S.

10.1101/2025.04.16.649225 — bioengineering — Posted on 2025-04-22

1657 Real-Time Visualization of Calcium Phosphate Formation on Titanium Dioxide Nanoparticles Using Liquid Transmission Electron Microscopy

Zhang, J.; DiCecco, L.-A.; Williams, A.; Merlo, A.; Grandfield, K.

10.1101/2025.04.16.648725 — bioengineering — Posted on 2025-04-22

1658 Single cell resolution of an epigenetic signature of persister tumor cell

Dumbrava, M.; Ismail, W. M.; Sandoval, L.; Mazzone, A.; Aalam, S. M. M.; Ritting, M. L.; Hou, X.; Xie, Y.; Harrington, S.; Kaufmann, S.; Kannan, N.; Weroha, S.; Gaspar-Maia, A.

10.1101/2025.04.16.649175 — genomics — Posted on 2025-04-22

1659 Titin cleavage in living cardiomyocytes induces sarcomere disassembly but does not trigger cell proliferation

Pricolo, M. R.; Lopez-Unzu, M. A.; Vicente, N.; Morales-Lopez, C.; Huerta-Lopez, C.; Perez-Franco, W.; Dumitru, A. C.; Espinosa, F. M.; Sanchez, M. I.; Garcia, R.; Silva-Rojas, R.; Herrero-Galan, E.; Alegre-Cebollada, J.

10.1101/2025.04.22.645658 — cell biology — Posted on 2025-04-22

1660 Early epigenetic priming of regeneration studied with a novel transgenic epigenetic reporter

Khor, J. M.; Cisneros, I.; Marvel, M.; Gore, A. V.; Taimatsu, K.; Margolin, G.; Castranova, D.; Goldstein, A.; Dale, R.; Weinstein, B. M.

10.1101/2025.04.21.649771 — genomics — Posted on 2025-04-22

1661 Insulated Outlier Chromosomes Drive Metabolic and Evolutionary Innovation in Minimal Eukaryotic Algae

Valiadi, M.; Harrison, K.; Loe-Mie, Y.; Williams, B. A. P.; Ankrett, D.; Smirnoff, N.; Monier, A.

10.1101/2025.04.21.649811 — evolutionary biology — Posted on 2025-04-22

1662 Populus VariantDB v3.2 facilitates CRISPR and Functional Genomics Research

Zhou, R.; Seth, S. R.; Reeves, J.; Burns, A. H.; Hsieh, C.; Horn, T.; Xue, L.-J.; Tsai, C.-J.

10.1101/2025.04.20.649720 — plant biology — Posted on 2025-04-22

1663 Complex structural variant visualization with SVTopo

Belyeu, J. R.; Rowell, W. J.; Lake, J. A.; Holt, J. M.; Kronenberg, Z.; Saunders, C. T.; Eberle, M. A.

10.1101/2025.04.16.649185 — bioinformatics — Posted on 2025-04-22

1664 Privacy-Preserving Generative AI Framework for Synthetic Multimodal Eye Movement Data

Rahman, A.; Bachina, P.; Patel, V.; Green, K. E.

10.1101/2025.04.21.649786 — bioengineering — Posted on 2025-04-22

1665 Deciphering the role of histone modifications in memory and exhausted CD8 T cells

Huang, H.; Baxter, A. E.; Zhang, Z.; Good, C. R.; Alexander, K. A.; Chen, Z.; Garcia, P. A. A.; Samareh, P.; Collins, S. M.; Glastad, K. M.; Wang, L.; Donahue, G.; Manne, S.; Giles, J. R.; Shi, J.; Berger, S. L.; Wherry, E. J.

10.1101/2025.04.16.649198 — immunology — Posted on 2025-04-22

1666 HIV IMPAIRS AND EXPLOITS PULMONARY TH17 AND TH22 CELL-MEDIATED IMMUNE RESPONSES TO MYCOBACTERIUM TUBERCULOSIS

Martinez-Martinez, Y. B.; Huante, M. B.; Naqvi, K. F.; Shah, M. N.; Lisinicchia, J. G.; Files, M. A.; Perez, J.; Gelman, B. B.; Endsley, M. A.; Endsley, J. J.

10.1101/2025.04.16.649152 — immunology — Posted on 2025-04-22

1667 Glia phagocytose neuronal sphingolipids to infiltrate developing synapses

Theisen, E. K.; Rivas-Serna, I. M.; Lee, R. J.; Jay, T. R.; Kunduri, G.; Nguyen, T. T.; Mazurak, V.; Clandinin, M. T.; Clandinin, T. R.; Vaughen, J. P.

10.1101/2025.04.14.648777 — neuroscience — Posted on 2025-04-22

1668 Croaking for haste: How long does it take to describe a frog species since its discovery?

Carne, A.; Sanchez-Vialas, A.; Lansac, C.; Moreno, M.; De la Riva, I. J.

10.1101/2025.04.17.649359 — zoology — Posted on 2025-04-22

1669 Long-range massively parallel reporter assay reveals rules of distal enhancer-promoter interactions

Wu, Y.; Li, J.; Bartley-Dier, E. L.; Pitts, C.; Cohen, B. A.

10.1101/2025.04.21.649048 — systems biology — Posted on 2025-04-22

1670 Metabolic modeling unveils potential probiotic roles of Flavonifractor plautii in reshaping the Western gut microbiota landscape

Scott, W. T.; Nataya, E. D.; Belzer, C.; Schaap, P. J.

10.1101/2025.04.16.649128 — systems biology — Posted on 2025-04-22

1671 The carbon footprint of science when it fails to self-correct

Farley, M.; Munafo, M. R.; Lewis, A.; Nicolet, B. R.

10.1101/2025.04.18.649468 — scientific communication and education — Posted on 2025-04-22

1672 Characterization and transcriptome analysis reveal abnormal pollen germination in cytoplasmic male sterile tomato

Kuwabara, K.; Ariizumi, T.

10.1101/2025.04.19.649671 — plant biology — Posted on 2025-04-22

1673 Leaf shape modulates climate trait relationships in the wild species Chenopodium hircinum (Amaranthaceae)

Rodriguez, J.; Quipildor, V.; Giamminola, E.; Bramardi, S.; Jarvis, D.; Maughan, J.; Xu, J.; Farooq, H.; Ortega-Baes, P.; Jellen, E.; Tester, M.; Bertero, D.; Curti, R. N.

10.1101/2025.04.21.649804 — plant biology — Posted on 2025-04-22

1674 High throughput screen of NPQ in sorghum shows highly polygenic architecture of photoprotection

Vath, R. L.; Fernandes, S.; Monier, B.; Glowacka, K.; Walter, J.; Lipka, A. E.; Ferguson, J. N.; Bernacchi, C.; Pederson, T.; Kromdijk, J.

10.1101/2025.04.18.649521 — plant biology — Posted on 2025-04-22

1675 Molecular Heterosis in the Abaca (Musa textilis Nee) BC2 Hybrid, Bandala

Ereful, N. C.; Alonday, R. S.; Lalusin, A. G.

10.1101/2025.04.21.649768 — plant biology — Posted on 2025-04-22

1676 Evaluating tree biomass estimation in trans-Atlantic mangrove species: comparing bole diameter measurements for improved accuracy

Price, C.; Schroeder, T. A.; Branoff, B.; Marcano-Vega, H.; Pillot-Torres, N.; Chaudry, M.; Ross, M.; Papes, M.; Van Bloem, S.

10.1101/2025.04.19.649682 — plant biology — Posted on 2025-04-22

1677 Five seasons with DeepRootLab: A unique facility for easier deep root research in the field

Han, E.; Clement, C.; Czaban, W.; Smith, A. G.; Dresboll, D. B.; Thorup-Kristensen, K.

10.1101/2025.04.20.649645 — plant biology — Posted on 2025-04-22

1678 Stepwise increase in plasmodesmata during C4 evolution in Flaveria

Aleksejeva, K.; Schreier, T. B.

10.1101/2025.04.18.649591 — plant biology — Posted on 2025-04-22

1679 Glucosylation of Endogenous Haustorium-inducing factors Underpins Kin Avoidance in Parasitic Plants

Xiang, L.; Cui, S.; Saucet, S. B.; Takahashi, M.; Inaba, S.; Xie, B.; Schilder, M.; Shimada, S.; Cui, M.; Watanabe, M.; Tobimatsu, Y.; Bouwmeester, H.; Tohge, T.; Shirasu, K.; Yoshida, S.

10.1101/2025.04.17.649457 — plant biology — Posted on 2025-04-22

1680 Tomato Omics Research: Mapping Bibliometric Footprints of Global Research Trends, Collaboration Networks, and Impact Trajectories

Prabha, R.; Kumar, A.; Shukla, R.; Singh, D. P.

10.1101/2025.04.17.649284 — plant biology — Posted on 2025-04-22

1681 Loss-of-Function RUP-Variants Influence Ubiquitin-Proteasome System and Enhance Carotenoid and Folate Levels in Tomato

Charakana, C.; Gupta, S. K.; Sunkum, A.; Valluri, S.; Bagri, J.; Tyagi, K.; Kumar, R.; Salava, H.; Kilambi, H. V.; Sivapuram, V.; Sharma, R.; Sreelakshmi, Y.

10.1101/2025.04.17.649262 — plant biology — Posted on 2025-04-22

1682 Exploring the potential of microbial inoculant to enhance common bean (Phaseolus vulgaris L.) yield via increased root nodulation and soil macro-nutrients

Fortu, S. T.; Tening, A. S.; Ndzeshala, S. T.; Ngosong, C.

10.1101/2025.04.17.649356 — plant biology — Posted on 2025-04-22

1683 Influence of Surfactant HLB Values and Agricultural Adjuvants on Pesticide Penetration in Plant Leaves

Bonn, D.

10.1101/2025.04.21.649273 — plant biology — Posted on 2025-04-22

1684 High-resolution genome and genetic map of tetraploid Allium porrum expose pericentromeric recombination

Nieuwenhuis, R.; Voorrips, R.; Esselink, D.; Hesselink, T.; Schijlen, E.; Arens, P.; Cordewener, J.; Scholten, O.; Peters, S.

10.1101/2025.04.21.649809 — plant biology — Posted on 2025-04-22

1685 ERF transcription factor regulons underpin growth-defence trade-off under acute heat stress in rice seedlings

Nair, A. U.; Vishwakarma, S.; Guha, T.; Kadumuri, R. V.; Fritschi, F. B.; Chavali, S.; Allu, A. D.

10.1101/2025.04.21.649784 — plant biology — Posted on 2025-04-22

1686 A citrullination-ubiquitination pathway controls pre-meiotic H1 eviction and is essential for gametogenesis in Arabidopsis

Li, Y.; Fei, D.; Schubert, J.; Rutowicz, K.; Kaczmarska, Z.; Linares, A.; Giraldo-Fonseca, A.; Bischof, S.; Grossniklaus, U.; Baroux, C.

10.1101/2025.04.18.649492 — plant biology — Posted on 2025-04-22

1687 Population analysis and immunologic landscape of melanoma in people living with HIV

Barger, L. N.; Wang, D.; Saravia, A.; Mezzano, V.; Ward, G.; Loomis, C.; Feldman, C.; Tuluc, M.; Seedor, R. S.; Gaskill, P. J.; Coghill, A. E.; Suneja, G.; Dehzangi, I.; Hope, J. L.; Romano, G.

10.1101/2025.04.17.648995 — cancer biology — Posted on 2025-04-22

1688 Unmapped reads from whole-genome sequencing data reveal pathogen diversity in European and African cattle breeds

Ruvinskiy, D.; Pokharel, K.; Okwasiimire, R.; Gonzales-Prendez, R.; Ginja, C.; Ghanem, N.; Kugonza, D. R.; Makgahlela, M. L.; Lindeberg, H.; Weldenegodguad, M.; Kantanen, J.; Derks, M.; Croojmans, R. P. M. A.

10.1101/2025.04.17.649267 — bioinformatics — Posted on 2025-04-22

1689 Frequency Chaos Game Representation - Singular Value Decomposition for Alignment-Free Phylogenetic Analysis

A, V.; Mangsuli, D.; Sinha, N.; Ramdas, S.

10.1101/2025.04.16.649090 — bioinformatics — Posted on 2025-04-22

1690 Cross-modal Denoising and Integration of Spatial Multi-omics data with CANDIES

Liu, Y.; Zou, W.; Li, Y.; Wang, J.; Cai, M.; Cai, H.

10.1101/2025.04.17.649333 — bioinformatics — Posted on 2025-04-22

1691 Vizitig: context-rich exploration of sequencing datasets

Degardins, B.; Paperman, C.; MARCHET, C.

10.1101/2025.04.19.649656 — bioinformatics — Posted on 2025-04-22

1692 Benchmarking long-read genome assemblers for three sequencing protocols and three agricultural species

Birbes, C.; Dreau, A.; Milan, D.; Iampietro, C.; Gaspin, C.; Donnadieu, C.; Zytnicki, M.; Klopp, C.

10.1101/2025.02.14.638238 — bioinformatics — Posted on 2025-04-22

1693 High quality genome assemblies of African cattle breeds using PacBio HiFi sequencing

Houaga, I.; Bhati, M.; Nziku, Z.; Nguluma, A.; Mapholi, N.; Nesengani, L. T.; Ogugo, M.; Sagbo, D. C. Y.; Zorobouragui, L.; Boco, M. B. Y.; Djikeng, A.; Prendergast, J. G. D.; Gorjanc, G.; Becher, H.

10.1101/2025.04.17.649430 — genomics — Posted on 2025-04-22

1694 Angel Wing: a class of alternative splicing regulators in animals

Zhang, T.; Li, K.; Ying, X.; Tan, X.; Tan, X.; Cui, M.; Rong, Y. S.

10.1101/2025.04.20.649734 — genetics — Posted on 2025-04-22

1695 SAI: A Python Package for Statistics for Adaptive Introgression

Huang, X.; Chen, S.; Hackl, J.; Kuhlwilm, M.

10.1101/2025.04.19.649497 — evolutionary biology — Posted on 2025-04-22

1696 Catastrophic drought effects on water quality and phytoplankton biomass in Nanwan Reservoir (Xinyang, China)

Wu, K.; Liu, X.; Tian, Y.; Ju, C.; Su, C.; Peng, X.; Ma, Y.; Gao, H.; Guo, X.

10.1101/2025.04.19.649684 — ecology — Posted on 2025-04-22

1697 PyReconstruct: A fully opensource, collaborative successor to Reconstruct

Chirillo, M. A.; Falco, J. N.; Musslewhite, M. D.; Lindsey, L. F.; Harris, K. M.

10.1101/2025.04.21.649793 — cell biology — Posted on 2025-04-22

1698 Phenotype-genotype discordance in antimicrobial resistance profiles of Gram-negative uropathogens recovered from catheter-associated urinary tract infections in Egypt

Eladawy, M.; Heslop, N.; Negus, D.; Thomas, J.; Hoyles, L.

10.1101/2025.04.17.649370 — microbiology — Posted on 2025-04-22

1699 SARS-CoV-2 nsp16 is regulated by host E3 ubiquitin ligases, UBR5 and MARCHF7

Tian, L.; Zhao, Z.; Gao, W.; Liu, Z.; Li, X.; Zhang, W.; Li, Z.

10.1101/2024.08.30.610469 — microbiology — Posted on 2025-04-22

1700 A conserved immune dysregulation is associated with infection severity, risk factors prior to infection, and treatment response

Ganesan, A.; Moore, A. R.; Zheng, H.; Toh, J.; Freedman, M.; Magis, A. T.; Heath, J. R.; Khatri, P.

10.1101/2025.04.18.649544 — immunology — Posted on 2025-04-22

1701 Feedforward Extraction of Behaviorally Significant Information by Neocortical Columns

Favorov, O. V.; Kursun, O.

10.1101/2025.04.20.649709 — neuroscience — Posted on 2025-04-22

1702 Postnatal development of the dentate gyrus vascular niche

Devasthali, N.; Carter, I.; Saulsbery, A.; Kirby, E. D.

10.1101/2025.04.21.649829 — neuroscience — Posted on 2025-04-22

1703 Enhanced reward coding and condition-independent dynamics in optogenetically identified corticostriatal neurons in monkeys

Joshua, M.; Hovav-Lixenberg, A.; Henshke, Y.; Kreisel, T.; Lottem, E.

10.1101/2025.04.21.649760 — neuroscience — Posted on 2025-04-22

1704 Task dependent cortico-cerebellar responses to delayed visual movement feedback

Vigh, G.; Limanowski, J.

10.1101/2025.04.17.649407 — neuroscience — Posted on 2025-04-22

1705 Combinative protein expression of immediate early genesc-Fos, Arc, and Npas4 along aversive- and reward-related neural networks

Arai, M.; Osanai, H.; Snell, C. C.; Kitamura, T.; Ogawa, S. K.

10.1101/2025.04.21.649441 — neuroscience — Posted on 2025-04-22

1706 Interactions between the medial prefrontal cortex, dorsomedial striatum, and dorsal hippocampus that support rat category learning

Broschard, M. B.; Kim, J.; Halverson, H. E.; Farley, S. J.; Freeman, J. H.

10.1101/2025.04.21.649785 — neuroscience — Posted on 2025-04-22

1707 Cognitive Mode Detectable with Task-Based fMRI: Default Mode B (DMB)

Ni, Y. Q. Y.; Redway, S.; Momeni, A.; Momeni, A.; Jian, L.; Yip, L.; Woodward, T. S.

10.1101/2025.04.21.649745 — neuroscience — Posted on 2025-04-22

1708 Single Cell Landscape of Sex-specific Drivers of Alzheimers Disease

Wu, Y.; Travaglini, K. J.; Gabitto, M.; Keene, D.; Dunn, A.; Kaczorowski, C.; Harari, O.; De Jager, P.; Menon, V.; Schneider, J. A.; Bennett, D. A.; Dumitrescu, L.; Hohman, T. J.

10.1101/2025.04.18.647076 — neuroscience — Posted on 2025-04-22

1709 Machine Learning-Driven fMRI Analysis for Objective Craving Prediction

Mahdavi-Doost, H.; Soleimani, G.; Lim, K.; Ekhtiari, H.

10.1101/2025.04.17.649130 — neuroscience — Posted on 2025-04-22

1710 Multiple variants of the mitochondrial COI DNA barcode region are prevalent in North European sawflies

Prous, M.; Urpilainen, S.; Hebert, P. D.; Zakharov, E.; Kiljunen, N.; Mutanen, M.

10.1101/2025.04.21.649769 — evolutionary biology — Posted on 2025-04-22

1711 Transcriptional noise sets fundamental limits to decoding circadian clock phase from single-cell RNA snapshots

Nikhat, A.; Mandal, T.; Veerasubramanian, N.; Chakrabarti, S.

10.1101/2024.06.30.601408 — systems biology — Posted on 2025-04-22

1712 A systematic assessment of phylogenomic approaches for microbial species tree reconstruction

Weiner, S.; Feng, Y.; Gogarten, J. P.; Bansal, M. S.

10.1101/2024.11.20.624597 — bioinformatics — Posted on 2025-04-21

1713 A multicellular actin star network underpins epithelial organization and connectivity

Barai, A.; Soleilhac, M.; Xi, W.; Lin, S.-Z.; Karnat, M.; Bazellieres, E.; Richelme, S.; Lecouffe, B.; Chardes, C.; Berrebi, D.; Ruemmele, F.; Thery, M.; Rupprecht, J.-F.; Delacour, D.

10.1101/2024.07.26.605277 — cell biology — Posted on 2025-04-22

1714 High-performance genetically-encoded green and red fluorescent biosensors for pyruvate

Imai, S.; Hario, S.; Suerte, C.; Yamaguchi, I.; Sakoi, K.; Terai, T.; Takahashi-Yamashiro, K.; Campbell, R. E.

10.1101/2025.04.17.649293 — molecular biology — Posted on 2025-04-21

1715 Fast Evolution of SOS-Independent Multi-Drug Resistance in Bacteria

Zhang, L.; Guan, Y.; Cheng, Y. Y.; Cokcetin, N. N.; Bottomley, A.; Robinson, A.; Harry, E.; van Oijen, A. M.; Su, Q. P.; Jin, D.

10.1101/2022.03.29.486198 — microbiology — Posted on 2025-04-21

1716 Carbonic anhydrase 4 disruption and pharmacological inhibition reduce synaptic and behavioral adaptations following oxycodone withdrawal

Gupta, S. C.; Taugher-Hebl, R. J.; Ghobbeh, A.; Jahnke, M. T.; Fan, R.; Lalumiere, R. T.; Wemmie, J. A.

10.1101/2025.01.23.634619 — neuroscience — Posted on 2025-04-21

1717 EasyEyes: Crowded Dynamic Fixation for Online Psychophysics

Hu, F.; Chen, J. Y. X.; Pelli, D. G.; Winawer, J.

10.1101/2025.02.26.640403 — neuroscience — Posted on 2025-04-21

1718 Frontoparietal Hubs Leverage Probabilistic Representations and Integrated Uncertainty to Guide Cognitive Flexibility

Leach, S. C.; Hollow, H.; Jiang, J.; Hwang, K.

10.1101/2025.03.21.644222 — neuroscience — Posted on 2025-04-21

1719 Employment of self-organisation to achieve economy of scale in biology

Siero, E.; Slegers, E.; Herman, K.; Bleichrodt, R.-J.

10.1101/2025.03.21.644553 — systems biology — Posted on 2025-04-21

1720 SLB-msSIM: a spectral library-based multiplex segmented SIM platform for single-cell proteomic analysis

Senavirathna, L.; Ma, C.; Duong, V. A.; Tsai, H.-Y.; Chen, R.; Pan, S.

10.1101/2024.10.22.618936 — systems biology — Posted on 2025-04-21

1721 A genetic toolbox for the high-resolution engineering of the plant growth-promoting agricultural bacterium Azospirillum brasilense.

Riley, E.; Poma, M.; Kelly, C. L.

10.1101/2025.04.08.647883 — synthetic biology — Posted on 2025-04-21

1722 Silicon regulation of pectin methyl-esterification and cellulose microfibril organization modulates FERONIA-mediated cell wall integrity signaling for rice adaptation to salt stress

Lei, Y.; Liu, Y.; Wei, J.; Li, W.; Zhang, S.; Yang, Z.; Feng, J.; Li, Y.; Sheng, H.

10.1101/2025.03.18.644059 — plant biology — Posted on 2025-04-21

1723 Human Papilloma Virus does not fully inactivate p53 cellular activity in HNSCC

Gencel-Augusto, J.; Li, H.; Woerner, L. C.; Borah, A. A.; Myers, J. N.; Ha, P.; Johnson, D. E.; Grandis, J. R.

10.1101/2025.02.11.637252 — cancer biology — Posted on 2025-04-21

1724 Phosphoproteomics Uncovers Tumor Heterogeneity and Therapeutic Opportunities in Early-Stage Hepatocellular Carcinoma

Ren, L.; Jiang, J.; Lin, W.; Qi, L.; Li, C.; Jiang, Y.

10.1101/2025.02.11.637605 — cancer biology — Posted on 2025-04-21

1725 Refining sequence-to-expression modelling with chromatin accessibility

Lapohos, O.; Fonseca, G. J.; Emad, A.

10.1101/2025.02.11.637651 — bioinformatics — Posted on 2025-04-21

1726 Bioprinting of Human Primary and iPSC-derived Islets with Retained and Comparable Functionality

Poklar, M.; K, R.; Wiegand, C.; Mizerak, B.; Wang, R.; Florentino, R. M.; Liu, Z.; Soto-Gutierrez, A.; Kumta, P. N.; Banerjee, I.

10.1101/2024.10.14.617656 — bioengineering — Posted on 2025-04-21

1727 Sexual swelling in bonobos: variations, ovulation predictability, and male responses

Ryu, H.; Hashimoto, C.; Hill, D. A.; Mouri, K.; Shimizu, K.; Furuichi, T.

10.1101/2022.03.13.483391 — animal behavior and cognition — Posted on 2025-04-21

1728 Evolutionarily Optimal Phage Life-History Traits: Burst Size vs. Lysis Time

Roughgarden, J.

10.1101/2025.04.16.649164 — evolutionary biology — Posted on 2025-04-21

1729 IPPK-1 and IP6 contribute to ventral nerve cord assembly in C. elegans

Noblett, N.; Roenspies, T.; Flibotte, S.; Colavita, A.

10.1101/2024.03.03.583222 — developmental biology — Posted on 2025-04-21

1730 Inflammasome activation dictates the efficacy of antimycobacterial activity of frontline TB drugs

Rao, V. K.; Singh, A.; Bisht, K.; Yadav, N.; Nanda, R.

10.1101/2025.04.02.646750 — microbiology — Posted on 2025-04-21

1731 Assembly and reasoning over semantic mappings at scale for biomedical data integration

Hoyt, C. T.; Karis, K.; Gyori, B. M.

10.1101/2025.04.16.649126 — bioinformatics — Posted on 2025-04-21

1732 scTrimClust: A Fast Approach to Robust scRNA-seq Analysis Using Trimmed Cell Clusters

Ruff, S.; Jung, K.

10.1101/2025.04.16.649082 — bioinformatics — Posted on 2025-04-21

1733 SeroBA(v2.0) and SeroBAnk: a robust genome-based serotyping scheme and comprehensive atlas of capsular diversity in Streptococcus pneumoniae

Lorenz, O.; King, A. C.; Hung, H. C. H.; Ganaie, F. A.; Wyllie, A. L.; Manna, S.; Satzke, C.; van der Linden, M.; Ravenscroft, N.; Slotved, H.-C.; McGee, L.; Nahm, M. H.; Bentley, S. D.; Lo, S. W.

10.1101/2025.04.16.648953 — bioinformatics — Posted on 2025-04-21

1734 Ridge Redundancy Analysis for High-Dimensional Omics Data

Yoshioka, H.; Aubert, J.; Iwata, H.; Mary-Huard, T.

10.1101/2025.04.16.649138 — bioinformatics — Posted on 2025-04-21

1735 Outcrossing Complicates Mutation Purging by Trapping Single Nucleotide Polymorphisms in Structural Variant Mutations

Kapila, R.; Saber, S.; Verma, R. K.; Blanco, G.; Eggers, V. K.; Fierst, J.

10.1101/2025.04.16.649179 — bioinformatics — Posted on 2025-04-21

1736 Cysteine Reactivity Profiling Illuminates Monoclonal Antibody Disulfide Bond Reduction Mechanisms in Biopharmaceutical Process Intermediates

Tsukidate, T.; Wang, Z.; Hsieh, A.; Rose, P.; Li, X.

10.1101/2025.04.16.649137 — bioengineering — Posted on 2025-04-21

1737 Seasonal and interannual variation of common dolphin densities in Portuguese waters

Martins, M.; Fernandez, M.; Marcalo, A.; Oliveira, N.; Marques, T. A.

10.1101/2025.04.16.649110 — ecology — Posted on 2025-04-21

1738 Legacy of the lost and pressure of the present: Malagasy plant seeds retain megafauna dispersal signatures but downsize under human footprint

Pu, Y.; Zizka, A.; Onstein, R. E.

10.1101/2025.04.16.649107 — ecology — Posted on 2025-04-21

1739 Nuclear 2'-O-methylation regulates RNA splicing through its binding protein FUBP1

Gao, B.; Jiang, B.; Zou, Z.; Liu, B.; Liu, W.; Chen, L.; Zhang, L.; He, C.

10.1101/2025.04.20.649728 — molecular biology — Posted on 2025-04-21

1740 Structural characterization of an extracellular contractile injection system from Photorhabdus luminescens in extended and contracted states.

Marin-Arraiza, L.; Roa-Eguiara, A.; Pape, T.; Sofos, N.; Hendriks, I. A.; Lund Nielsen, M.; Steiner-Rebrova, E. M.; Taylor, N. M. I.

10.1101/2025.04.20.649488 — molecular biology — Posted on 2025-04-21

1741 RIP2 inhibits DOCK8-mediated platelet dense granule release and alleviates experimental myocardial infarction

Zhang, J.; Zhang, Z.; Pan, G.; Liu, Y.; Chang, L.; Qi, Z.; Zhang, Y.; Zhang, S.; Qiao, J.; Xi, X.; Dai, K.; Dong, J.; Ding, Z.

10.1101/2025.04.19.649674 — molecular biology — Posted on 2025-04-21

1742 Distinct Bomanins at the Drosophila 55C locus function in resistance and resilience to infections

Lou, Y.; Zhang, B.; Zhang, Z.; Pan, Y.; Yang, J.; Li, L.; Huang, J.; Yuan, Z.; Liegeois, S.; Bulet, P.; Xu, R.; Li, Z.; FERRANDON, D.

10.1101/2025.04.16.649162 — immunology — Posted on 2025-04-21

1743 Aicardi-Goutieres Syndrome Associated ADAR G1007R mutation dominantly induces neuroinflammation in mouse brain

Guo, X.; Liu, J.-J.; Shang, C.; Guerriero, C.; Wiley, C.; Steinman, R.; Sheng, Y.; Brodsky, J.; Billiar, T.; Liu, S.; Wang, Q.

10.1101/2025.04.21.649787 — neuroscience — Posted on 2025-04-21

1744 Bat power-metabolic profiling of the Egyptian fruit bat Rousettus aegyptiacus reveals distinctive cardiac adaptations

Karlstaedt, A.; Cullen, F.; Drinkwater, R.; Kim, K.; Young, M.; Rossiter, S.; Aksentijevic, D.

10.1101/2025.04.16.649087 — systems biology — Posted on 2025-04-21

1745 Metabolic modeling unveils potential probiotic roles of Flavonifractor plautii in reshaping the Western gut microbiota landscape

Scott, W. T.; Nataya, E. D.; Belzer, C.; Schaap, P. J.

10.1101/2025.04.16.649128 — systems biology — Posted on 2025-04-21

1746 Automated Bacteriophage Evolution Studies with the Aionostat

Druelle, V.; Molari, M.; Castagnetti, G.; Harms, A.; Neher, R. A.

10.1101/2025.04.16.649189 — evolutionary biology — Posted on 2025-04-21

1747 Greater Expression of DNA Repair Pathways in Sharks vs. Rays/Skates Based on Transcriptomic Analyses

Simmons, C. R.; Grant, S. L.; Llorente Ruiz, L.; Kerstetter, D. W.; Pimpley, M.; Latimer, J. J.

10.1101/2025.04.20.649719 — molecular biology — Posted on 2025-04-21

1748 Evaluation of nanopore sequencing for increasing accessibility of eDNA studies in biodiverse countries

Gygax, D.; Urban, L.; Ramirez, S.; Chibesa, M.; Simpamba, T.; Riffel, M.; Riffel, T.; Srivathsan, A.; Nijland, R.

10.1101/2025.04.21.649756 — molecular biology — Posted on 2025-04-21

1749 Spatial and Temporal Patterns of Public Transit Aerobiomes

Orr, R. J.; Brynildsrud, O.; Boifot, K. O.; Gohli, J.; Skogan, G.; Kelly, F. J.; Hernandez, M. T.; Udekwu, K.; Lee, P. K.; Mason, C.; Dybwad, M.

10.1101/2025.04.21.649744 — microbiology — Posted on 2025-04-21

1750 Nucleoid Compaction Influences Carboxysome Localization and Dynamics in Synechococcus elongatus PCC 7942

Dudley, C. E.; Azaldegui, C. A.; Foust, D.; LaCommare, O.; Biteen, J. S.; Vecchiarelli, A. G.

10.1101/2025.04.21.649805 — microbiology — Posted on 2025-04-21

1751 Exploring the double-stranded DNA viral landscape in eukaryotic genomes

Zhao, H.; Meng, L.; Zhang, R.; Gaia, M.; Ogata, H.

10.1101/2025.04.19.649669 — microbiology — Posted on 2025-04-21

1752 Evaluation of cytotoxic effects of diverse essential oils on human keratinocytes (HaCaT)

Surowiak, A. K.; Poreba, M.; Strub, D. J.

10.1101/2025.04.16.649163 — pharmacology and toxicology — Posted on 2025-04-21

1753 The novel RNA polymerase I transcription inhibitor PMR-116 exploits a critical therapeutic vulnerability in a broad-spectrum of high MYC malignancies.

Ferreira, R.; Hannan, K. M.; Panov, K.; Udumanne, T.; George, A. J.; Closa, A.; Yuen, Z.; Eyras, E.; Poh, P.; Maclachlan, K.; Dwyer, M.; Barn, V.; He, J.; Kusnadi, E.; Rebello, R.; Huglo, A.; Hedwards, S.; Lawrence, M.; Risbridger, G.; Taylor, R.; Clark, A.; Farrell, G.; Pok, S.; Teoh, N.; Amarasini, M.; Norcott, P. L.; Banwell, M. G.; Manenkova, Y.; Haddach, M.; Drygin, D.; Furic, L.; Hannan, R. D.; Hein, N.

10.1101/2025.04.19.649466 — cancer biology — Posted on 2025-04-21

1754 Modeling glioma-induced impairments on the glymphatic system

Poulain, A.; Riseth, J. N.; Emblem, K. E.; Mardal, K.-A.

10.1101/2025.04.16.648938 — biophysics — Posted on 2025-04-21

1755 A Beauty Dye Staining (ABDS) - inexpensive marker-ink based open-source alternative for commercial membrane vital dyes

Abelit, A. A.; Boytsova, N. A.; Kornev, A. A.; Yakovleva, L. E.; Daniil, S. D.

10.1101/2025.04.16.645980 — biophysics — Posted on 2025-04-21

1756 ANARCII: A Generalised Language Model for Antigen Receptor Numbering

Greenshields-Watson, A.; Agarwal, P.; Robinson, S. A.; Williams, B. H.; Gordon, G. L.; Capel, H. L.; Li, Y.; Spoendlin, F. C.; Boyles, F.; Deane, C. M.

10.1101/2025.04.16.648720 — bioinformatics — Posted on 2025-04-21

1757 Efficient trace reconstruction in DNA storage systems using Bidirectional Beam Search

Gu, Z.; Xin, H.; Sharma, P.; Goh, G. Y.; Wong, L.; Nagarajan, N.

10.1101/2025.04.16.644694 — bioinformatics — Posted on 2025-04-21

1758 The oral cavity of chronically homeless adults is home for unusual extremophile environmental bacteria

Ruiz-Coronel, A.; Sandoval-Motta, S.; Melendez-Sanchez, D.; Larios-Serrato, V.; Torres, R. C.; Torres, J.

10.1101/2025.04.16.649188 — bioinformatics — Posted on 2025-04-21

1759 Multimodal control of Cas13 activity through domain insertion at an allosteric hotspot

Zhu, L.; Nguyen, L. T.; Bell, A. G.; Gillmann, K. M.; Oatman, H.; Hariri, J.; Myhrvold, C. E.; Toettcher, J. E.

10.1101/2025.04.21.649818 — bioengineering — Posted on 2025-04-21

1760 Discovery of a wide variety of α-1,6-cyclized β-1,2-glucan synthases: a new entrance for host-microbe interactions.

Motouchi, S.; Kim, I.; Ishiguro, A.; Niu, K.; Komba, S.; Kashima, T.; Kitano, Y.; Nakai, H.; Nakajima, M.

10.1101/2025.04.21.649730 — biochemistry — Posted on 2025-04-21

1761 Pollen sterols are highly diverse but phylogenetically conserved

Baker, E.; Lamborn, E.; Quinonez, J.; karlsdottir, s.; Shepard, A.; Moore, E.; Kunin, B.; Wright, G.; Stevenson, P.

10.1101/2025.04.21.649781 — biochemistry — Posted on 2025-04-21

1762 Cell-type-specific transposable element demethylation and TAD remodeling in the aging mouse brain

Zeng, Q.; Tian, W.; Klein, A.; Bartlett, A.; Liu, H.; Nery, J. R.; Castanon, R. G.; Osteen, J.; Johnson, N.; Wang, W.; Ding, W.; Chen, H.; Altshul, J.; Kenworthy, M.; Valadon, C.; Owens, W.; Wu, Z.; Amaral, M. L.; Song, Y.; Baez-Becerra, C. T.; Cho, S.; Chen, C.; Willier, J.; Cao, S.; Rink, J.; Lee, J.; Barcoma, A.; Arzavala, J.; Emerson, N.; Lu, Y. R.; Ren, B.; Behrens, M. M.; Ecker, J. R.

10.1101/2025.04.21.648266 — genomics — Posted on 2025-04-21

1763 Fieldable isothermal nucleic acid test for rapid semi-quantitative visual readout of Enterococci in recreational waters

Sudarshan, A.; Rillera, M. G.; Tran, N.; Riedel, T. E.; Ellington, A. D.; BHADRA, S.

10.1101/2025.04.20.649722 — molecular biology — Posted on 2025-04-21

1764 A conserved, immune-regulated peritrophin promotes Vibrio cholerae colonization of the arthropod intestine

Barraza, D.; Paulo, T. F.; Findley, L.; Hang, S.; Watnick, P.

10.1101/2025.04.21.649765 — microbiology — Posted on 2025-04-21

1765 The influence of ceftriaxone, ceftazidime-avibactam, and piperacillin-tazobactam on the gut microbiota

Huang, G.; Cai, L.; Guo, J.; Zhu, R.; Zhu, L.

10.1101/2025.04.19.649511 — microbiology — Posted on 2025-04-21

1766 Low-cost DIY bioreactor system for educational and research applications: an accessible off-the-shelf bubble column concept

Gandia, A.; Christiansen, S.

10.1101/2025.04.21.649716 — microbiology — Posted on 2025-04-21

1767 Accelerated evolution of whole gene clusters by an engineered lytic phage system in E. coli

Ong, S.; Ghode, P.; Narenderan, A.; Willenborg, F.; Eden, T. V.; Lao, S.; Marsh, C. O.; Yew, W. S.; Fredens, J.

10.1101/2025.04.21.649713 — synthetic biology — Posted on 2025-04-21

1768 Redefining paradigms in the archaeal virus-host arms race

Martinez Alvarez, L.; Peng, X.

10.1101/2025.04.20.649705 — microbiology — Posted on 2025-04-21

1769 A small molecule inhibitor of RNA-binding protein IGF2BP3 shows anti-leukemic activity

Jaiswal, A. K.; Scherer, G. M.; Thaxton, M. L.; Sorrentino, J. P.; Yuen, C.; Mehta, M. M.; Sharma, G.; Lin, T. L.; Tran, T. M.; Cohen, A.; Ritter, A. J.; Kotecha, R. S.; Sanford, J. R.; Damoiseaux, R. D.; Garg, N. K.; Rao, D. S.

10.1101/2025.04.14.648780 — cancer biology — Posted on 2025-04-21

1770 Inferring tumour microenvironment ecosystems from scRNA-seq atlases

Yu, C.; Geuenich, M. J.; Ge, S.; Jang, G.-H.; Ju, T. T.; Zhang, A.; O'Kane, G.; Notta, F.; Campbell, K. R.

10.1101/2024.08.21.608956 — bioinformatics — Posted on 2025-04-21

1771 The Genome of Chenopodium ficifolium: Developing Genetic Resources and a Diploid Model System for Allotetraploid Quinoa

Ludwig, C. D.; Maughan, P. J.; Jellen, E. N.; Davis, T. M.

10.1101/2025.01.17.633571 — genetics — Posted on 2025-04-21

1772 Obesity promotes urinary tract infection by disrupting urothelial immune defenses

Schwartz, L.; Salamon, K.; Simoni, A.; Cotzomi-Ortega, I.; Sanchez-Zomora, Y.; Linn-Peirano, S.; John, P.; Ruiz-Rosado, J. d. D.; Jackson, A. R.; Wang, X.; Spencer, J. D.

10.1101/2025.04.04.647270 — cell biology — Posted on 2025-04-21

1773 Transient SUMOylation Inhibition Induces Stable Epigenetic Beiging Fate In Human White Adipocytes

Nothnagel, P. M.; Briand, N.; Wik, J. A.; Strom, Y. E.; Bjoras, M.; Enserink, J. M.; Skalhegg, B. S.; Mathelier, A.; Chymkowitch, P.

10.1101/2025.03.07.642034 — molecular biology — Posted on 2025-04-21

1774 Mechanisms of AAV neutralization by human alpha-defensins

Porter, J. M.; Hulce, K. R.; Oswald, M. S.; Busuttil, K.; Emmanuel, S. N.; Bennett, A.; McKenna, R.; Smith, J. G.

10.1101/2024.09.25.614754 — microbiology — Posted on 2025-04-21

1775 Oral Administration of Boldine Reduces Spare Nerve Injury-Induced Neuropathic Pain

Pan, J.; Toro, C. A.; Chow, C.; Duarte, Y.; Saez, J. C.; Cardozo, C. P.; Zhao, W.

10.1101/2024.11.05.622128 — neuroscience — Posted on 2025-04-21

1776 3D directional tuning in the orofacial sensorimotor cortex during natural feeding and drinking

Hosack, V. B.; Arce-McShane, F. I.

10.1101/2024.07.02.601741 — neuroscience — Posted on 2025-04-21

1777 The lnc-FANCI-2 intrinsically restricts RAS signaling in HPV16-infected cervical cancer

Liu, H.; Yu, L.; Majerciak, V.; Meyer, T.; Yi, M.; Johnson, P. F.; Cam, M.; Lowy, D. R.; Zheng, Z.-M.

10.1101/2024.02.01.578320 — cancer biology — Posted on 2025-04-21

1778 SORBET: Automated cell-neighborhood analysis of spatial transcriptomics or proteomics for interpretable sample classification via GNN

Shimonov, S.; Cunningham, J.; Talmon, R.; Aizenbud, L.; Desai, S.; Rimm, D.; Schalper, K.; Kluger, H.; Kluger, Y.

10.1101/2023.12.30.573739 — bioinformatics — Posted on 2025-04-21

1779 One-step generation of modified cattle and sheep from spermatid-like haploid stem cells

Yang, L.; Di, A.; Song, L.; Liu, X.; Wu, D.; Wang, S.; Hao, Z.; Bu, L.; Bai, C.; Su, G.; Wei, Z.; Zhang, L.; Liu, Z.; Gao, S.; Li, G.

10.1101/2024.09.10.612264 — bioengineering — Posted on 2025-04-21

1780 Cross-family Signaling: PDGF Mediates VEGFR Activation and Endothelial Function

Liu, X.; Fang, Y.; Imoukhuede, P.

10.1101/2025.02.27.640684 — bioengineering — Posted on 2025-04-21

1781 Effects of urbanization on the microbial fungal communities from water, sediment, and amphibian hosts across a rural-to-urban waterway in Worcester, Massachusetts

Wheeler, S. J.; DelCogliano, M.; Hare, B.; Bradshaw, A. J.; Hincher, M. R.; Carleton, J. P.; Bergmann, P. J.; Ahlgren, N. A.; Tabima, J. F.

10.1101/2025.04.01.646624 — ecology — Posted on 2025-04-21

1782 Robust coexistence in ecological competitive communities

Lechon-Alonso, P.; Kundu, S.; Lemos-Costa, P.; Capitan, J. A.; Allesina, S.

10.1101/2024.07.10.602979 — ecology — Posted on 2025-04-21

1783 The condensate-forming protein eIF4ET ensures adequate levels of meiotic proteins to support oocyte storage

Bhatia, P.; Tafur, J.; Amin, R.; Familiari, N. E.; Yaguchi, K.; Tran, V. M.; Bond, A.; Bukulmez, O.; Woodruff, J. B.

10.1101/2024.10.29.620718 — developmental biology — Posted on 2025-04-21

1784 Larval zebrafish maintain elevation with multisensory control of posture and locomotion

Davis, S. N.; Zhu, Y.; Schoppik, D.

10.1101/2024.01.23.576760 — neuroscience — Posted on 2025-04-21

1785 Functionally Adaptive Structural Basis Sets of the Brain: A Dynamic Fusion Approach

Duda, M.; Chen, J.; Belger, A.; Ford, J.; Mathalon, D.; Preda, A.; Turner, J. A.; Van Erp, T.; Pearlson, G. D.; Calhoun, V.

10.1101/2024.06.18.599621 — neuroscience — Posted on 2025-04-21

1786 Speech markers of psychedelic-induced psychological change

Kuc, J.; McAlpine, R. G.; Sellers, A.; Blackburne, G.; Lametti, D. R.; Skipper, J. I.

10.1101/2025.04.16.649217 — neuroscience — Posted on 2025-04-21

1787 The Dual Molecular Identity of Vestibular Kinocilia: Bridging Structural and Functional Traits of Primary and Motile Cilia

Xu, Z.; Tavakoli, A.; Kulasooriya, S.; Liu, H.; Tu, S.; Bloom, C.; Li, Y.; Zuo, J.; Tao, L.; Kachar, B.; He, D. Z. Z.

10.1101/2025.04.16.647417 — neuroscience — Posted on 2025-04-21

1788 Alpha-1 Antitrypsin Overexpressing Mesenchymal Stem/Stromal Cells Reverses Type 1 Diabetes via Promoting Treg Function and CD8+ T cell exhaustion

Wang, H.; Wei, H.; Gou, W.; Kim, J.; Subramanian, S.; Yeung, T.; Chakraborty, P.; Mehrotra, S.; Berto, S.; Strange, C.

10.1101/2025.04.19.649667 — cell biology — Posted on 2025-04-21

1789 Transcriptional plasticity of stromal cells amplifies their differentiation efficiency in vitro

Jamil, A. J. M.; Rauch, A.

10.1101/2025.04.18.649582 — cell biology — Posted on 2025-04-21

1790 Constitutive cGAS-STING activation in ALT+ cells

Geelen, D.; Beacom, A.; Vaurs, M.; Mahieu, M.; Boutoual, R.; Derumier, A.; Hoerr, R.; Loriot, A.; Nassour, J.; Decottignies, A.

10.1101/2025.04.18.649516 — cell biology — Posted on 2025-04-21

1791 Multivalent assembly of PAR-3/aPKC complexes establishes cell polarity in C. elegans zygotes

Hsu, S.-P.; Dickinson, D. J.

10.1101/2025.04.16.649205 — cell biology — Posted on 2025-04-21

1792 Cell cycle control of cohesion establishment

Rankin, B. D.; Moore, V.; Flavors, D.; Rankin, S.

10.1101/2025.04.18.649605 — cell biology — Posted on 2025-04-21

1793 Nuclear envelope budding is a non-canonical mechanism to export large transcripts in muscle cells

Zaganelli, S.; Meehl, J.; Abrisch, R. G.; Voeltz, G. K.

10.1101/2025.04.18.649598 — cell biology — Posted on 2025-04-21

1794 FilaBuster: A Strategy for Rapid, Specific, and Spatiotemporally Controlled Intermediate Filament Disassembly

Moore, A. S.; Krug, T.; Hansen, S. B.; Ludlow, A. V.; Grimm, J. B.; Ayala, A. X.; Plutkis, S. E.; Wang, N.; Goldman, R. D.; Medalia, O.; Lavis, L. D.; Weitz, D. A.; Lippincott-Schwartz, J.

10.1101/2025.04.20.649718 — cell biology — Posted on 2025-04-21

1795 Mechanism of USP21 autoinhibition and histone H2AK119 deubiquitination

Rahman, S.; Morgan, M. T.; Hicks, C. W.; Gwizdala, A.; Wolberger, C.

10.1101/2025.04.17.649347 — biophysics — Posted on 2025-04-21

1796 Rare codon translation regulates growth factor-dependent cell proliferation

Ma, Y.; Pronovost, S. M.; Lewis, M. R.; Scherzer, M. T.; Shen, J.; Edgar, B. A.

10.1101/2025.04.17.648825 — cell biology — Posted on 2025-04-21

1797 BLTP2 orchestrates lysobisphosphatidic acid synthesis and exosome biogenesis via SCAMP3-dependent ER contacts in tumorigenesis

Ji, W.; wang, j.; Li, D.; liu, y.; zhou, t.; xiong, j.

10.1101/2025.04.17.649455 — cell biology — Posted on 2025-04-21

1798 Senescence-induced reparative fibroblasts enable scarless wound healing in aged murine skin.

Wang, D.; Wang, Z.; Yang, Y.; Bai, F.; Li, H.; He, J.; Zhou, F.; Chen, T.; Fang, T.; Wu, Z.; Zhong, J.; Xiang, L.; Man, Y.; Wu, Y.

10.1101/2025.04.17.648896 — cell biology — Posted on 2025-04-21

1799 Live Eco-AI, Electrophoresis-Correlative Data-Dependent Acquisition with Artificial Intelligence-Based Data Processing Democratizes Single-Cell Mass Spectrometry Proteomics

Shen, B.; Zhou, F.; Nemes, P.

10.1101/2025.04.16.649123 — cell biology — Posted on 2025-04-21

1800 The Magnitude of Telomere Shortening per Cell Division In Vivo: Implications for Lifelong Hematopoiesis in Humans

Harris, J. R.; Steenstrup, T.; Aviv, A.

10.1101/2025.04.16.649166 — cell biology — Posted on 2025-04-21

1801 Cannabis use in humans is associated with impaired implicit motor learning and supranormal baseline cortical activity

Prashad, S.; Paek, A. Y.; Fournier, L. R.

10.1101/2025.04.16.647328 — neuroscience — Posted on 2025-04-21

1802 A Non-Canonical Interface of SNX9 PX Domain Selectively Sequesters PI(3,4)P2 Lipids, Protecting Them from Hydrolysis

Beiter, J.; Sung, C.-J.; Lin, S.-S.; DeVuono, N.; Arumugam, S.; Manzi, J.; Bertin, A.; Bassereau, P.; Liu, Y.-W.; Voth, G. A.; Tsai, F.-C.

10.1101/2025.03.26.645564 — biophysics — Posted on 2025-04-21

1803 Spatial Adaptation of Primate Retinal Ganglion Cells between Artificial and Natural Stimuli

Vystrcilova, M.; Sridhar, S.; Burg, M. F.; Khani, M. H.; Karamanlis, D.; Schreyer, H. M.; Ramakrishna, V.; Krüppel, S.; Zapp, S. J.; Mietsch, M.; Gollisch, T.; Ecker, A. S.

10.1101/2025.04.09.647910 — systems biology — Posted on 2025-04-21

1804 A high-quality genomic catalog of the human oral microbiome broadens its phylogeny and clinical insights

Cha, J. H.; Kim, N.; Ma, J.; Lee, S.; Koh, G.; Yang, S.; Beck, S.; Byeon, I.; Lee, B.; Lee, I.

10.1101/2025.03.10.642329 — microbiology — Posted on 2025-04-21

1805 Exploring influenza A virus receptor distribution in the lactating mammary gland of domesticated livestock and in human breast tissue.

Nelli, R. K.; Harm, T. A.; Arruda, B.; Siepker, C.; Fasina, O.; Groeltz, J.; Baker, A.; Phillips, R.; Jones, B.; Espina, V.; Seger, H.; Plummer, P.; Bell, T.

10.1101/2025.04.16.649193 — immunology — Posted on 2025-04-21

1806 Optogenetic Stimulation of Single Ganglion Cells in the Living Primate Fovea

Murphy, P.; McGregor, J.; Xu, Z.; Merigan, W.; Williams, D.

10.1101/2023.07.21.550081 — neuroscience — Posted on 2025-04-21

1807 Thalamic Nuclei Volumes Across Psychiatric and Neurological Disorders: A Multi-Site Magnetic Resonance Imaging Study

Maki-Marttunen, V.; Nerland, S.; Jorgensen, K.; Hogestol, E.; Rokicki, J.; Alnaes, D.; Borgwardt, S.; Boye, B.; Buitelaar, J.; Boen, E.; Cervenka, S.; Conzelmann, A.; Erhardt, S.; Franke, B.; Celius, E.; Harbo, H.; Hilland, E.; Hoekstra, P.; Hartman, C.; Jonassen, R.; Jonsson, E.; Landro, N.; Lesch, K.-P.; Maglanic, L.; Pauli, P.; Sellgren, C.; Nygaard, G.; Oosterlaan, J.; Schmidt, A.; Schwarz, E.; Ziegler, G.; Agartz, I.; Westlye, L.; Andreassen, O.; Kaufmann, T.; Elvsashagen, T.

10.1101/2025.04.21.649628 — neuroscience — Posted on 2025-04-21

1808 Decomposed Linear Dynamical Systems (dLDS) models reveal context-dependent dynamic connectivity in C. elegans

Yezerets, E.; Mudrik, N.; Charles, A.

10.1101/2024.05.31.596903 — neuroscience — Posted on 2025-04-21

1809 NOX4 prevents the recruitment of PAX8 and NKX2.1 to chromatin in BRAF-mutated thyroid cancer cells.

Radom, M.; Buffet, C.; Cazarin, J.; Harinquet, M.; Coelho de Faria, C.; Braye, F.; Nobre, C.; Aglave, M.; Mesloub, Y.; Dayris, T.; DROIN, N.; Godefroy, K.; Bani, M.-A.; Al Ghuzlan, A.; Leboulleux, S.; Lamartina, L.; DUPUY, C.

10.1101/2025.04.14.647724 — cancer biology — Posted on 2025-04-21

1810 Influencing Iron Homeostasis by Transition Metal Complexes Interacting with a messenger-RNA Stem Loop in the Iron Regulating Element

Hognon, C.; Froux, A.; Grandemange, S.; MONARI, A.

10.1101/2025.02.19.639007 — biophysics — Posted on 2025-04-21

1811 Evolution of the cellular landscape in mammalian striatum

Buyukkahraman, G.; Caglayan, E.; Hoerpel, S. G.; Zhang, Y.; van Tussenbroek, I. A.; Orozco, C. G.; Oh, E.; Hopkins, W. D.; Sherwood, C. C.; Roberts, T. F.; Vernes, S. C.; Konopka, G.

10.1101/2025.04.20.649707 — genomics — Posted on 2025-04-21

1812 Multiple human enhancer RNAs contain long translated open reading frames

Vlasov, P. A.; Ogami, K.; Valenzuela, E.; Kawaguchi, R. K.; Jovanovic, M.; Manley, J. L.

10.1101/2025.04.18.649583 — molecular biology — Posted on 2025-04-21

1813 Recombination alters the receptor binding and furin cleavage site in novel bat-borne HKU5-CoV-2 coronavirus

Yeh, T.-Y.; Tsai, V.; Liao, S. M.; Hong, C.-E.; Kuo, F.-Y.; Wang, Y. C.; Feehley, M. C.; Feehley, P. J.; Lai, Y.-C.; Contreras, G. P.

10.1101/2025.04.17.649446 — microbiology — Posted on 2025-04-21

1814 Control of two-pathway signal integration in a model neocortical pyramidal cell

Graham, B. P.; Kay, J.; Phillips, W. A.

10.1101/2025.04.21.649759 — neuroscience — Posted on 2025-04-21

1815 The role of inhibitory neurons in novelty sound detection in regular and random statistical contexts.

Ding, X.; Vogler, N. W.; Tobin, M.; Garami, L.; Wood, K. C.; Geffen, M. N.

10.1101/2025.04.20.649735 — neuroscience — Posted on 2025-04-21

1816 Kinocilia of Vestibular Hair Cells: Bridging Structural and Functional Traits of Primary and Motile Cilia

Xu, Z.; Tavakoli, A.; Kulasooriya, S.; Liu, H.; Tu, S.; Bloom, C.; Li, Y.; Zuo, J.; Tao, L.; Kachar, B.; He, D. Z. Z.

10.1101/2025.04.16.647417 — neuroscience — Posted on 2025-04-21

1817 Unsupervised feature computation-based feature selection robustly extracted resting-state functional connectivity patterns related to mental disorders

Yamashita, A.; Itahashi, T.; Sakai, Y.; Takamura, M.; Togo, H.; Yoshihara, Y.; Okada, T.; Yamagata, H.; Harada, K.; Takagishi, H.; Hosomi, K.; Okada, N.; Abe, O.; Okada, G.; Okamoto, Y.; Hashimoto, R.; Hanakawa, T.; Murai, T.; Matsuo, K.; Takahashi, H.; Kasai, K.; Hayashi, T.; Koike, S.; Tanaka, S. C.; Kawato, M.; Imamizu, H.; Yamahshita, O.; Brain/MINDS Beyond Human Brain MRI Group,

10.1101/2025.04.14.648842 — neuroscience — Posted on 2025-04-21

1818 HIF-1α/STOML2 mediated PINK1-dependent mitophagy activation against hypoxia-induced neuronal injury

Li, Y.; Guo, M.; Tian, Z.; Shao, Q.; Liu, Y.; Gu, Y.; Xu, Z.; Jin, F.; Ji, X.; Liu, J.

10.1101/2025.04.16.649120 — neuroscience — Posted on 2025-04-21

1819 Arcuate Fasciculus: Evolutionary Convergence in Marmosets and Humans

Wang, Y.; Cheng, L.; Li, D.; Lu, Y.; Hopkins, W.; Sherwood, C.; Xu, T.; Liu, C.; Paxinos, G.; Jiang, T.; Chu, C.; Fan, L.

10.1101/2025.04.21.649746 — neuroscience — Posted on 2025-04-21

1820 ER fusogens maintain membrane reservoir to ensure brain function

Miao, H.; Wang, Y.; Huang, Y.; Zhang, H.; Zheng, L.; Zhou, X.; Wang, X.; Xie, Q.; Xue, L.; Hu, J.

10.1101/2025.04.12.648519 — neuroscience — Posted on 2025-04-21

1821 CERIUM OXIDE NANOPARTICLES ATTENUATE THE PRO-ARRHYTHMIC EFFECT OF DIESEL EXHAUST PARTICLES IN ISOLATED RAT HEARTS BY REDUCING OXIDATIVE STRESS.

Ganse, F. G.; Ernst, L. M.; Rodriguez, C.; Ruiz-Meana, M.; Inserte, J.; Martinez-Gonzalez, J.; Briones, A. M.; Garcia-Redondo, A. B.; Consegal, M.; Miro-Casas, E.; Yanez-Bisbe, L.; Pomposo, A.; Prades-Martinez, M.; Ferreira-Gonzalez, I.; Puntes, V.; Benito, B.; Rodriguez-Sinovas, A.

10.1101/2025.04.11.648481 — pharmacology and toxicology — Posted on 2025-04-21

1822 Protein Electrostatic Properties are Fine-Tuned Through Evolution

Shen, M.; Dayhoff, G. W.; Shen, J.

10.1101/2025.04.17.649309 — biophysics — Posted on 2025-04-21

1823 Whole-genome sequencing revealed local genetic differences and multi-layered genetic structure in brown bear (Ursus arctos) populations

Endo, Y.; Osada, N.; Mano, T.; Abramov, A. V.; Masuda, R.

10.1101/2025.04.21.649633 — evolutionary biology — Posted on 2025-04-21

1824 In vivo CRISPR screening identifies regulators of hyperplastic and hypertrophic adipose remodelling in zebrafish

Wafer, R.; Tandon, P.; Minchin, J. E.

10.1101/2025.04.20.649706 — developmental biology — Posted on 2025-04-21

1825 Fasting Rescues Locomotion in Neuromodulation-Deficient C. elegans via Octopamine-Gαq Signaling

He, J.; Ou, G.; Li, W.

10.1101/2025.04.19.649495 — neuroscience — Posted on 2025-04-21

1826 IL-17 sensitises sensory neurons and colonic afferents to noxious stimuli in a PI3K dependent manner

Paine, L. W.; Higham, J. P.; Barker, K. H.; Pavlou, S.; Welsh, F.; Smith, E. S. J.; Bulmer, D.

10.1101/2025.04.16.649143 — neuroscience — Posted on 2025-04-21

1827 Whole-gut spatial genomic analysis reveals molecular regionalization of the differentiating zebrafish enteric nervous system

Moreno-Campos, R.; Mummaneni, N. S.; Uribe, R. A.

10.1101/2025.04.17.649413 — neuroscience — Posted on 2025-04-21

1828 Nonlinear modulation of human exploration by distinct sources of uncertainty

Yan, X.; Ebitz, B. R.; Darrow, D. P.; Herman, A. B.

10.1101/2025.04.16.649221 — neuroscience — Posted on 2025-04-21

1829 Egocentric body-axis-related and allocentric clover-like tuning of object vector representations supports human spatial cognition

Becu, M.; Krasovec, I. M.; Saldanha, P.; Whitlock, J.; Doeller, C. F.

10.1101/2025.04.18.649400 — neuroscience — Posted on 2025-04-21

1830 Thalamic Nuclei Volumes Across Psychiatric and Neurological Disorders: A Multi-Site Magnetic Resonance Imaging Study

10.1101/2025.04.21.649628 — neuroscience — Posted on 2025-04-21

1831 Identification of MARVELlous Protein Markers for Phytophthora infestans Extracellular Vesicles

Breen, S.; McLellan, H.; Wang, W.; Wang, S.; Welsh, L.; Pham, J.; Whisson (SW), s.; Boevink, P.; Birch, P. R.

10.1101/2025.04.11.648357 — plant biology — Posted on 2025-04-21

1832 Omics-driven Identification of Candidate Genes and SNP markers in a Major QTL Controlling Early Heading in Rice

Rao, D.; T, N. S.; CG, G.; Gaur, N.; Jamaloddin, M.; Maganti, S. M.; Raman, M. S.; Patel, H. K.; Tiwari, S.; Sonti, R. V.

10.1101/2025.03.25.645207 — plant biology — Posted on 2025-04-21

1833 Synaptic Spine Head Morphodynamics from Graph Grammar Rules for Actin Dynamics

Hur, M.; Bartol, T.; Rangamani, P.; Sejnowski, T.; Mjolsness, E.

10.1101/2025.04.18.649558 — biophysics — Posted on 2025-04-21

1834 GPU-accelerated homology search with MMseqs2

Kallenborn, F.; Chacon, A.; Hundt, C.; Sirelkhatim, H.; Didi, K.; Cha, S.; Dallago, C.; Mirdita, M.; Schmidt, B.; Steinegger, M.

10.1101/2024.11.13.623350 — bioinformatics — Posted on 2025-04-21

1835 Benchmarking Encoding Strategies for Non-Coding Mutations in Sequence-Based Prediction Tasks

Liu, Z.; Bao, Y.; Li, W.; Yang, C.; Wang, W.; Cai, W.; Li, W.; Lin, G. N.

10.1101/2025.01.01.631025 — bioinformatics — Posted on 2025-04-21

1836 The heterogeneity of dermal mesenchymal cells reproduced in skin equivalents regulates barrier function and elasticity

Kimura, S.; Sekiya, S.; Yamashiro, S.; Kikuchi, T.; Haga, M.; Shimizu, T.

10.1101/2024.12.08.627431 — bioengineering — Posted on 2025-04-21

1837 Heritability of human lifespan is about 50% when confounding factors are addressed

Shenhar, B.; Pridham, G.; de Oliveira, T. L.; Yang, Y.; Raz, N.; Deelen, J.; Hagg, S.; Alon, U.

10.1101/2025.04.20.649385 — genetics — Posted on 2025-04-21

1838 Evolution of the olfactory system during the radiation of Heliconiini butterflies

Toh, Y. P.; Cicconardi, F.; Bianchini, G.; Merrill, R. M.; Montgomery, S. H.

10.1101/2025.04.06.647427 — evolutionary biology — Posted on 2025-04-21

1839 The assembly of microbial communities on red sandstone surfaces was shaped by dispersal limitation and heterogeneous selection

Wang, B.; Zhu, C.; Wang, X.; Yang, T.; Zhang, B.; Hu, Y.

10.1101/2024.10.02.616369 — ecology — Posted on 2025-04-21

1840 WITHDRAWN: GLOWORM-META: Modelling gastrointestinal nematode metapopulation dynamics to inform cattle biosecurity research

Ingle, O. K.; Melville, L.; Beechener, S.; Hardy, C.; Howell, A.; Hobbs, N. P.; Mahon, N.; Morgan, E. R.; Bartley, D.; Rose Vineer, H.

10.1101/2025.02.21.639461 — ecology — Posted on 2025-04-21

1841 Leishmania secretory factor GP63 targets the DICER1/miR-122/hepcidin axis in host macrophages to deplete Nramp1

Samanta, S.; Banerjee, S.; Datta, R.

10.1101/2025.04.16.649108 — cell biology — Posted on 2025-04-21

1842 Human CCR4 deadenylase homolog Angel1 is a Non-Stop mRNA Decay factor

Nicholson-Shaw, T.; Dowdle, M. E.; Ajaj, Y.; Perelis, M.; Fulzele, A.; Yeo, G. W.; Bennett, E. J.; Lykke-Anderson, J.

10.1101/2022.04.28.489582 — molecular biology — Posted on 2025-04-21

1843 Identification of ambisense kolmioviruses

Kishimoto, M.; Imai, S.; Igarashi, M.; Horie, M.

10.1101/2025.01.08.631871 — microbiology — Posted on 2025-04-21

1844 CD81+ senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis

Fu, L.; Yin, C.; Zhao, Q.; Guo, S.; Shao, W.; Xia, T.; Sun, Q.; Chen, L.; Li, J.; Wang, M.; Xia, H.

10.1101/2024.02.21.581332 — immunology — Posted on 2025-04-21

1845 JAK inhibitors remove innate immune barriers facilitating viral propagation

Ravlo, E.; Ianevski, A.; Skipperstoen, M.; Lysvand, H.; Schjolberg, J.-O.; Solheim, O. S.; Wang, W.; Kissova, M.; Vestrik, M.; Vapalahti, O.; Smura, T.; Vauhkonen, H.; Oksenych, V.; Weber, F.; Strand, M.; Evander, M.; Malmring, J.; Afset, J. E.; Bjoras, M.; Kainov, D. E.

10.1101/2025.02.17.638720 — immunology — Posted on 2025-04-21

1846 Accumbal Dopamine and Acetylcholine Dynamics during Psychostimulant Sensitization

Lange, G.; Gnazzo, F.; Faust, R. P.; Beeler, J. A.

10.1101/2025.03.29.646091 — neuroscience — Posted on 2025-04-21

1847 Suite3D: Volumetric cell detection for two-photon microscopy

Haydaroglu, A.; Chang, T.; Landau, A.; Krumin, M.; Dodgson, S.; Baruchin, L. J.; Cozan, M.; Guo, J.; Meyer, D.; Reddy, C. B.; Zhong, J.; Ji, N.; Schröder, S.; Harris, K. D.; Vaziri, A.; Carandini, M.

10.1101/2025.03.26.645628 — neuroscience — Posted on 2025-04-21

1848 Geometry-preserving vector field reconstruction of high-dimensional cell-state dynamics using ddHodge

Maehara, K.; Ohkawa, Y.

10.1101/2025.04.16.649050 — systems biology — Posted on 2025-04-21

1849 Quantitative analysis of gas chromatography-coupled electroantennographic detection (GC-EAD) of plant volatiles by insects

Byers, K. J. R. P.; Jacobs, R. N.

10.1101/2024.12.01.626223 — plant biology — Posted on 2025-04-21

1850 Structural variations contribute to subspeciation and heterosis in rice

Dan, Z.; Chen, Y.; Huang, W.

10.1101/2024.11.03.621459 — plant biology — Posted on 2025-04-21

1851 The autophagy-related genes AtATG5 and AtATG7 influence reserve mobilisation and responses to ABA during seed germination in Arabidopsis thaliana

Contreras, E.; Sanchez-Vicente, I.; Pastor-Mora, E.; Aylon-Rodriguez, M.; Gonzalez-Ceballos, M.; Delgado-Gutierrez, M. A.; Lorenzo, O.; Vicente-Carbajosa, J.; Iglesias-Fernandez, R.

10.1101/2024.05.15.593177 — plant biology — Posted on 2025-04-21

1852 Collagenesis Orchestrates Mechanoadaptive Homeostasis of Intervertebral Disc

He, J.; Huang, S.; Li, Y.; Wang, Y.; Yan, P.; Hu, O.; Lin, P.; Jin, H.; Zhu, J.; Zhang, L.; Liu, Y.; Qin, Q.; Guo, Y.; Zheng, X.; Xie, Y.; Chen, L.; Lan, Y.; Liu, B.; Liu, P.; Gan, Y.

10.1101/2023.07.24.550303 — physiology — Posted on 2025-04-21

1853 Dynamical properties of chromatin provide insights into key folding principles

Kadam, S.; Sahoo, S.; Kumar, P. B. S.; Padinhateeri, R.

10.1101/2024.05.07.592992 — biophysics — Posted on 2025-04-21

1854 CAMP: A modular metagenomics analysis system for integrated multi-step data exploration

Mak, L.; Tierney, B.; Wei, W.; Ronkowski, C.; Brizola Toscan, R.; Turhan, B.; Toomey, M.; Martinez, J. S. A.; Fu, C.; Lucaci, A. G.; Barrios Solano, A. H.; Setubal, J. C.; Henriksen, J. R.; Zimmerman, S.; Kopbayeva, M.; Noyvert, A.; Iwan, Z.; Kar, S.; Nakazawa, N.; Meleshko, D.; Horyslavets, D.; Kantsypa, V.; Frolova, A.; Kahles, A.; Danko, D.; Elhaik, E.; Labaj, P.; Mason, C.; Hajirasouliha, I.

10.1101/2023.04.09.536171 — bioinformatics — Posted on 2025-04-21

1855 Unified integration of spatial transcriptomics across platforms

Haber, E.; Deshpande, A.; Ma, J.; Krieger, S.

10.1101/2025.03.31.646238 — bioinformatics — Posted on 2025-04-21

1856 miRNA Mimic Optimization: Chemical Structure - Activity - Targetome Relationship to Engineer Selective Anti-Tumor Immunity in T cells

Segarra-Visent, X.; Ryaykenen, T.; Kremer, A.; Sauer, M.; Jackson, S.; Cooper, D. A.; Echeverria, D.; Haraszti, R. A.

10.1101/2025.04.16.649059 — bioengineering — Posted on 2025-04-21

1857 Learning is a fundamental source of behavioral individuality

Manna, R.; Brea, J.; Braga, G. V.; Modirshanechi, A.; Tomic, I.; Jaksic, A. M.

10.1101/2024.08.30.610528 — animal behavior and cognition — Posted on 2025-04-21

1858 Stable coexistence and transport of lytic phage infections with migrating bacterial hosts

Marchi, J.; Khalek, C.; George, A.; Weitz, J. S.; Chait, R.

10.1101/2025.04.18.649568 — ecology — Posted on 2025-04-21

1859 Impacts on the microbial fungal communities across water, sediment, and amphibian hosts across an urbanization gradient waterway in Worcester, Massachusetts

Wheeler, S. J.; DelCogliano, M.; Hare, B.; Bradshaw, A. J.; Hincher, M. R.; Carleton, J. P.; Bergmann, P. J.; Ahlgren, N. A.; Tabima, J. F.

10.1101/2025.04.01.646624 — ecology — Posted on 2025-04-21

1860 Bclaf1 biomolecular condensates protect nuclear PTK2 from ubiquitin-proteasome system promoting cardiomyocyte survival during oxidative stress

Aparecida Moretto, I.; Rodrigues, B. R. I.; Victor-Carvalho, P.; Carvalho, M. d. G. d. S.; Silva, M. C. d.; Valdivieso-Rivera, F. B.; Araujo, G. L. d.; Samogim, A. P.; Novais, L. B.; de Brito, I. R.; Reis-de-Oliveira, G.; Amaral, A. G.; Baratti, M. O.; Basei, F. L.; Geraldo, M. V.; Carvalho, P. C.; Santos, M. D. M.; Duran, R.; Sponton, C.; Kobarg, J.; Gozzo, F. C.; Carvalho, H. F.; Thomaz, A. A. d.; Santos, A. M. d.

10.1101/2025.02.04.636487 — cell biology — Posted on 2025-04-21

1861 Heritability of human lifespan is about 50% when confounding factors are addressed

Shenhar, B.; Pridham, G.; de Oliveira, T. L.; Yang, Y.; Raz, N.; Deelen, J.; Hagg, S.; Alon, U.

10.1101/2025.04.20.649385 — genetics — Posted on 2025-04-21

1862 Trait reward sensitivity and behavioral motivation shape connectivity between the default mode network and the striatum during reward anticipation

Wyngaarden, J. B.; Nambiar, A.; Dennison, J. B.; Alloy, L. B.; Fareri, D.; Jarcho, J. M.; Smith, D. V.

10.1101/2025.04.17.649386 — neuroscience — Posted on 2025-04-21

1863 Excitatory drive to the globus pallidus external segment facilitates action initiation in non-human primates

Yoshida, A.; Hikosaka, O.

10.1101/2025.04.16.649214 — neuroscience — Posted on 2025-04-21

1864 Evidence for an active handoff between cerebral hemispheres during target tracking

Broschard, M. B.; Roy, J. D.; Brincat, S. L.; Mahnke, M. K.; Miller, E. K.

10.1101/2025.04.18.649553 — neuroscience — Posted on 2025-04-21

1865 Opponent regulation of striatal output pathways by dopamine and serotonin

Pinto, D. F. C.; Guo, M. Y.; Morishita, W.; Pomrenze, M. B.; Eshel, N.; Malenka, R. C.

10.1101/2025.04.17.649431 — neuroscience — Posted on 2025-04-21

1866 How infant brains fold: Sulcal deepening is linked to development of sulcal span, thickness, curvature, and microstructure

Tung, S. S.; Yan, X.; Fascendini, B.; Tyagi, C. G.; Reyes, C. M.; Ducre, K.; Perez, K.; Allen, A.; Horenziak, J.; Wu, H.; Keil, B.; Natu, V. S.; Grill-spector, K.

10.1101/2025.04.18.649604 — neuroscience — Posted on 2025-04-21

1867 Widespread gray and white matter microstructural alterations in dual cognitive-motor impairment

Singh, K.; An, Y.; Schilling, K.; Benjamini, D.

10.1101/2025.04.18.649603 — neuroscience — Posted on 2025-04-21

1868 Cerebellum instructs plasticity in the mouse primary somatosensory cortex

Silbaugh, A.; Koster, K. P.; Hansel, C.

10.1101/2025.04.18.649578 — neuroscience — Posted on 2025-04-21

1869 Reproducibility of PD patient-specific midbrain organoid data for in vitro disease modelling.

Zuccoli, E.; Al Sawaf, H.; Tuzza, M.; Nickels, S.; Zagare, A.; Schwamborn, J. C.

10.1101/2025.04.17.649331 — neuroscience — Posted on 2025-04-21

1870 Infralimbic prefrontal cortical projections to the autonomic brainstem: Quantification of inputs to cholinergic and adrenergic/noradrenergic nuclei

Lukinic, E.; Wallace, T.; McCartney, C.; Myers, B.

10.1101/2025.04.17.649459 — neuroscience — Posted on 2025-04-21

1871 When Melodies Cue Memories: Electrophysiological Correlates of Autobiographically Salient Music Listening in Older Adults

Vuong, V.; O'Neil, M. J.; Dimitrijevic, A.; Buchsbaum, B. R.; Thaut, M. H.; Alain, C.

10.1101/2025.04.16.649223 — neuroscience — Posted on 2025-04-21

1872 Association between Cortical Thickness and Functional Response to Linguistic Processing in the Occipital Cortex of Early Blind Individuals

Czarnecka, M.; Hryniewiecka, K.; Wolna, A.; Baumbach, C.; Beck, J.; Vadlamudi, J.; Collignon, O.; Jednorog, K.; Szwed, M.; Stroh, A.-L.

10.1101/2025.04.17.645592 — neuroscience — Posted on 2025-04-21

1873 Population-level constraints on single neuron tuning changes during behavioral adaptation

Stealey, H. M.; Zhao, Y.; Lu, H.-Y.; Contreras-Hernandez, E.; Chang, Y.-J.; Tobler, P. N.; Lewis-Peacock, J. A.; Santacruz, S. R.

10.1101/2025.04.17.649401 — bioengineering — Posted on 2025-04-21

1874 VN1K: a genome graph-based and function-driven multi-omics and phenomics resource for the Vietnamese population

Tran, T. T. H.; Hoang, T. H.; Tran, M. H.; Nguyen, N. T.; Nguyen, D. T.; Pham, T.; Pham, T. M.; Nguyen, N. N.; Vu, G. M.; Duong, V. C.; Vu, Q. T.; Nguyen, T. K.; Nguyen, T. M.; Vu, H. Q.; Dang, T.; Nguyen, H.; Do, T.; Le, C.; Nguyen, H. T. T.; Le, N. Q.; Le, L. T.; Vu, D. M.; Ngo, T. D.; Le, H. T. T.; Nguyen, L. T.; Ha, T. C.; Hoang, Y.; Dao, D. X.; Giang, P. H.; Luu, H. N.; Dao, M. D.; Le, L.; Le, V. S.; Tran, T.; Nguyen, Q.; Le, D.-H.; Nguyen, D. T.; Vu, V. H.; Vo, N. S.

10.1101/2025.04.15.648991 — genomics — Posted on 2025-04-21

1875 Inferring domestic goat demographic history through ancient genome imputation

10.1101/2025.04.18.649576 — genomics — Posted on 2025-04-21

1876 alms1 regulates the immune response and brain ageing in zebrafish

Bea-Mascato, B.; Mendez-Martinez, L.; Costas-Prado, C.; Guerrero-Pena, L.; Suarez-Bregua, P.; Rotllant, J.; Valverde, D.

10.1101/2025.04.19.639742 — genomics — Posted on 2025-04-21

1877 Dorsoventral limb patterning in paired appendages emerged via regulatory repurposing of an ancestral posterior fin module

Zdral, S.; Bordignon, S. G.; Meyer, A.; Ros, M. A.; Woltering, J. M.

10.1101/2025.04.16.648507 — evolutionary biology — Posted on 2025-04-21

1878 Evidence of parental care as a novel reproductive isolating mechanism

Behrens, C.; Maciejewski, M. F.; Sumarli, A.; Lucas, G.; Lagunas-Robles, G.; Samuk, K.; Bell, A. M.

10.1101/2025.04.18.649590 — evolutionary biology — Posted on 2025-04-21

1879 Preconditioning of human iPSCs with doxorubicin causes genome-wide transcriptional reprogramming in iPSC-derived cardiomyocytes linked to mitochondrial dysfunction and impaired cardiac regeneration

Westerhoff, M.; Brocke-Ahmadinejad, N.; Schaumkessel, Y.; Köhrer, K.; Dönmez, A.; Ghodrat, R.; Borchardt, A.; Enjuanes-Ruiz, L.; Tigges, J.; Koch, K.; Fritz, G.; Kondadi, A. K.; Reichert, A. S.

10.1101/2025.04.18.649376 — cell biology — Posted on 2025-04-21

1880 Genomic and Phenotypic Characterization of Mupirocin Resistant Staphylococcus aureus Clinical Isolates

Virgillio, A. M.; Felton, E. A.; Jackson, J. K.; Kennedy, S. J.; Becker, D. N.; Lima, A.; Atrubin, K.; Cella, E.; Azarian, T.; Silbert, S.; Shaw, L. N.; Kim, K.

10.1101/2025.04.16.648996 — microbiology — Posted on 2025-04-21

1881 Exploring influenza A virus receptor distribution in the lactating mammary gland of domesticated livestock and in human breast tissue.

Harm, T. A.; Arruda, B.; Siepker, C.; Fasina, O.; Groeltz, J.; Baker, A.; Phillips, R.; Jones, B.; Espina, V.; Seger, H.; Plummer, P.; Bell, T.; Nelli, R. K.

10.1101/2025.04.16.649193 — immunology — Posted on 2025-04-21

1882 Stroke Shifts Brain Dynamics Toward Criticality: Evidence from Intrinsic Neural Timescales

Wu, K.; Jelfs, B.; Fang, Q.; Gollo, L. L.

10.1101/2025.04.10.647205 — neuroscience — Posted on 2025-04-21

1883 Updated neuronal numbers of the rat hippocampal formation: redesigning the hippocampal model.

Arellano, J. I.; Rakic, P.

10.1101/2025.04.16.649153 — neuroscience — Posted on 2025-04-21

1884 Plasticity of interhemispheric motor cortex connectivity induced by brain state-dependent cortico-cortical paired-associative stimulation

Ermolova, M.; Kozak, G.; Belardinelli, P.; Ziemann, U.

10.1101/2025.04.16.648589 — neuroscience — Posted on 2025-04-21

1885 Biophysical mechanisms of default mode network function and dysfunction

Nghiem, T.-A. E.; Menon, V.

10.1101/2025.04.16.649208 — neuroscience — Posted on 2025-04-21

1886 Causal Contributions of Left Inferior and Medial Frontal Cortex to Semantic and Executive Control

Martin, S.; Ferrante, M.; Bruera, A.; Hartwigsen, G.

10.1101/2025.04.16.649200 — neuroscience — Posted on 2025-04-21

1887 Speech markers of psychedelic-induced psychological change

Kuc, J.; McAlpine, R. G.; Sellers, A.; Blackburne, G.; Lametti, D.; Skipper, J. I.

10.1101/2025.04.16.649217 — neuroscience — Posted on 2025-04-21

1888 Breaking the Link: Neural Dissociation of Attention and Working Memory through Inhibitory Control

Liu, Y.; Fu, Y.; Tang, E.; Wu, H.; Han, J.; Xie, M.; Zhang, Y.; Huang, J.; Liu, H.; Chen, H.; Qin, P.

10.1101/2025.04.17.649277 — neuroscience — Posted on 2025-04-21

1889 Inharmonicity enhances brain signals of attentional capture and auditory stream segregation

Basinski, K.; Celma-Miralles, A.; Quiroga-Martinez, D. R.; Vuust, P.

10.1101/2025.04.17.649377 — neuroscience — Posted on 2025-04-21

1890 Feature-dependent decorrelation of sound representations across the auditory pathway

Gosselin, E.; Bagur, S.; Jamali, S.; Puel, J.-L.; Bourien, J.; Bathellier, B.

10.1101/2025.04.17.649364 — neuroscience — Posted on 2025-04-21

1891 Flexible value coding in the mesolimbic dopamine system depending on internal water and sodium balance

Ozawa, T.; Nakagawa, I.; Uchida, Y.; Abe, M.; Macpherson, T.; Yamashita, Y.; Hikida, T.

10.1101/2025.04.16.649233 — neuroscience — Posted on 2025-04-21

1892 All spectral frequencies of neural activity reveal semantic representation in the human anterior ventral temporal cortex

Frisby, S. L.; Halai, A. D.; Cox, C. R.; Clarke, A.; Shimotake, A.; Kikuchi, T.; Kuneida, T.; Arakawa, Y.; Takahashi, R.; Ikeda, A.; Matsumoto, R.; Rogers, T. T.; Lambon Ralph, M. A.

10.1101/2025.04.17.649404 — neuroscience — Posted on 2025-04-21

1893 Improving science communication and organization visibility through Wikipedia: A case study of the American Association for Anatomy

Pascoe, M. A.

10.1101/2025.04.15.648547 — scientific communication and education — Posted on 2025-04-21

1894 Serving as an anatomy laboratory teaching assistant does not improve USMLE Step 1 performance

Pascoe, M. A.

10.1101/2025.04.15.648844 — scientific communication and education — Posted on 2025-04-21

1895 Dissecting Genotype-Environment interactions with functional implications for parental selection in Cannabis Breeding

Halpin-McCormick, A.; Thomson, R.; Clarke, R. C.; Neyhart, J.; Kantar, M. B.

10.1101/2025.04.17.649228 — plant biology — Posted on 2025-04-21

1896 Single-Cell Pharmacogenomic Landscapes of Epigenetic Therapy in Gastric Cancer

Xu, C.; Ma, H.; Sheng, T.; Lee, M. H.; Abdul Ghani, S. A. B.; Perlaza-Jimenez, L.; Huang, K. K.; Lim, S. K.; Srivastava, S.; Ong, X.; Tay, S. T.; Ho, S. W. T.; Tan, A. L. K.; Zhu, F.; Nasca, V.; Randon, G.; Ashktorab, H.; Cheng, A. S.-L.; Jeyasekharan, A. D.; Li, S.; Teh, M.; Sundar, R.; Powell, D. R.; Rosenbluh, J.; Pietrantonio, F.; Yong, W. P.; So, J. B.-Y.; Tan, P.

10.1101/2025.04.16.649236 — cancer biology — Posted on 2025-04-21

1897 PseudoChecker2 and PseudoViz: automation and visualization of gene loss in the Genome Era

Pinto, R.; Ruivo, R.; Stiller, J.; da Fonseca, R.; Castro, F.

10.1101/2025.04.11.648399 — bioinformatics — Posted on 2025-04-21

1898 Challenges in predicting protein-protein interactions of understudied viruses: Arenavirus-Human interactions

Sahni, H.; Crotzer, S. M.; Moore, J.; Branda, S. S.; Estrada, T.; Gnanakaran, S.

10.1101/2025.04.16.649136 — bioinformatics — Posted on 2025-04-21

1899 OPTIMIZING AN EXOTENDON AT AN INCREASED RUNNING SPEED

Stingel, J.; Bianco, N. A.; Ong, C.; Hicks, J. L.; Delp, S.

10.1101/2025.04.15.648814 — bioengineering — Posted on 2025-04-21

1900 A novel inducible mtDNA mutator mouse model to study mitochondrial dysfunction with temporal and spatial control

Tobias-Wallingford, H.; Bartman, S.; Gaspar, L.; Gallagher, B.; Bassa, C.; Sotirakis, E.; Dubus, V.; Hemme, C.; Olson, L.; Coppotelli, G.; Ross, J. M.

10.1101/2025.04.17.649454 — genetics — Posted on 2025-04-21

1901 Predicting long and short-term species persistence following invasion of ecological communities

Vikrant, A.

10.1101/2025.04.16.649095 — ecology — Posted on 2025-04-21

1902 Live-cell imaging reveals nutrient-dependent dynamics of ER-mitochondria contact formation via PDZD8

Aoyama-Ishiwatari, S.; Nakamura, K.; Nagao, T.; Hirabayashi, Y.

10.1101/2025.04.17.649323 — cell biology — Posted on 2025-04-21

1903 Biotic interactions shape the realised niche of toxic cyanobacteria

Ntetsika, P.; Eyring, S.; Merz, E.; Reyes, M.; Kaech, B.; Munch, S.; Dennis, S.; Baity Jesi, M.; Pomati, F.

10.1101/2025.04.16.649070 — ecology — Posted on 2025-04-20

1904 Influence of duty-cycle recording on measuring bat activity in passive acoustic monitoring

Krishna, A.; Lee, W.-J.

10.1101/2025.04.15.649046 — ecology — Posted on 2025-04-20

1905 Therapeutic Effect of Anti-FABP4 mAb (6H2) on Systemic Inflammation in Sepsis: Insights from Abdominal Organ Analysis

IBRAHIM, M. M.; Li, C.; Yinzhong, M.; Fang, C.

10.1101/2025.04.16.649067 — immunology — Posted on 2025-04-20

1906 Knowledge-driven annotation for gene interaction enrichment analysis

Liu, X.; Jiang, A.; Lyu, C.; Chen, L.

10.1101/2025.04.15.649030 — bioinformatics — Posted on 2025-04-20

1907 Widespread discordance between mRNA expression, protein abundance and de novo lipogenesis activity in hepatocytes during the fed-starvation transition

Landgraf, A.; Okada, J.; Horton, M.; Liu, L.; Solomon, S.; Qiu, Y.; Kurland, I. J.; Sidoli, S.; Pessin, J. E.; Shinoda, K.

10.1101/2025.04.15.649020 — bioinformatics — Posted on 2025-04-20

1908 Body Fluid Estimation during Standard Ultrafiltration in Chronic Kidney Disease

Abohtyra, R. M.; Beg, O. A.

10.1101/2025.04.15.648978 — bioengineering — Posted on 2025-04-20

1909 Improving Thermal and Gastric Stability of Phytase via pH Shifting and Coacervation: A Demonstration of Bayesian Optimization for Rapid Process Tuning

Khongkomolsakul, W.; Buathong, P.; Yang, E.; Dadmohammadi, Y.; Zhou, Y.; Li, P.; Yang, L.; Frazier, P.; Abbaspourrad, A.

10.1101/2025.04.18.649602 — biochemistry — Posted on 2025-04-20

1910 Cellularly-Retained Fluorogenic Probes for Sensitive Cell-Resolved Bioactivity Imaging

Mauker, P.; Dessen-Weissenhorn, L.; Zecha, C.; Veprek, N.; Brandmeier, J.; Beckmann, D.; Kitowski, A.; Kernmayr, T.; Thorn-Seshold, J.; Kerschensteiner, M.; Thorn-Seshold, O.

10.1101/2025.04.17.649302 — biochemistry — Posted on 2025-04-20

1911 CArP - CApture-based sequencing for Pathogen surveillance in complex matrices

Stege, P. B.; Harders, F.; Bossers, A.; Brouwer, M. S. M.

10.1101/2025.04.20.648581 — genomics — Posted on 2025-04-20

1912 Sexual division of labour shapes hunter-gatherer spatial ranges

Padilla-Iglesias, C.; Nganga, D.; Amboulou, E.; Ruf, J.; Averti Ifo, S.; Vinicius, L.; Migliano, A. B.

10.1101/2025.04.15.649057 — evolutionary biology — Posted on 2025-04-20

1913 A Method for Preparing Morphologically Preserved Wildlife Fecal Specimens for Long-Term Ecological Studies

Jiahao, Z.; Dongling, Z.; Xinrui, X.; Yunqiao, Z.; Qiang, D.

10.1101/2025.04.15.649043 — ecology — Posted on 2025-04-20

1914 Progesterone Receptor Expressing Basal Cells and Progesterone Receptor-Primed Progenitors Redefine the Mammary Epithelial Hierarchy

Tharmapalan, P.; Waas, M.; McCloskey, C. W.; Defamie, V.; Aliar, K.; Simoes, B. M.; Clarke, R. B.; Howell, S. J.; Kislinger, T.; Berman, H. K.; Waterhouse, P.; Khokha, R.

10.1101/2025.04.16.648786 — cell biology — Posted on 2025-04-20

1915 Aerobic glycolysis and lactate regulate histone H3K18Lactylation occupancy to fine-tune gene expression in developing and mature retina

Gaur, M.; Liang, X.; Brooks, M. J.; Jiang, K.; Kumari, A.; English, M. A.; Cifani, P.; Antonelli, M. C.; Nellissery, J.; Fariss, R. N.; Campello, L.; Marchal, C.; Swaroop, A.

10.1101/2025.04.17.649437 — molecular biology — Posted on 2025-04-20

1916 Induction of anergy in human T lymphocytes by exposure to single amino acid mutated antigens

Futatsugi, Y. N.

10.1101/2025.04.15.649051 — immunology — Posted on 2025-04-20

1917 Precon_all: A species-agnostic automated pipeline for non-human cortical surface reconstruction

Benn, R. A.; Xu, T.; Mars, R. B.; Boch, M.; Roumazeilles, L.; Heuer, K.; Toro, R.; Margulies, D. S.; Manzano-Patron, J. P.; Montesinos, P.; Galan-Arriola, C.; Lopez-Martin, G.; Sanchez-Gonzalez, J.; Duff, E. P.; Ibanez, B.

10.1101/2025.04.16.649072 — neuroscience — Posted on 2025-04-20

1918 In vivo MRI measurement of microstructural constraints for direct delivery of therapeutics within the brain

Castellano, A.; Pieri, V.; Segato, A.; Riva, M.; Pecco, N.; Yuan, T.; Vidotto, M.; Zani, D. D.; Brizzola, S.; Trovatelli, M.; Ravasio, G.; Secoli, R.; Galvan, S.; Dini, D.; Bello, L.; Rodriguez y Baena, F.; De Momi, E.; Falini, A.

10.1101/2025.04.15.648763 — neuroscience — Posted on 2025-04-20

1919 Nanobinders for Synaptotagmin 1 enable the analysis of synapticvesicle dynamics in rodent and human models.

Goel, R.; Jevdokimenko, K.; Rhem, R.; Hentze, J.; Agui-Gonzalez, P.; Ninov, M.; Lange, F.; Witkowska, A.; Bolz, S.; Pennacchietti, F.; Damenti, M.; Kaempf, N.; Khayenko, V.; Calatayud, C.; Malviya, V. N.; Chanaday, N. L.; Scaletti Hutchinson, E.; Liu, H.; Weyand, K.; Ivanova, D.; Wallis, T.; Small, C.; Maric, H. M.; Joensuu, M.; Cousin, M. A.; Meunier, F. A.; Verstreken, P. A.; Testa, I.; Kavalali, E. T.; Haucke, V.; Jakobs, S.; Urlaub, H.; Brose, N.; Cooper, B. H.; Stenmark, P.; Opazo, F.; Jahn, R.; Rizzoli, S. O.; Fornasiero, E. F.

10.1101/2025.04.16.649111 — neuroscience — Posted on 2025-04-20

1920 Neurologically altered brain activity may not look like aged brain activity: Implications for brain-age modeling and biomarker strategies

Gemein, L.; Gaubert, S.; Paquet, C.; Paillard, J.; Holst, S. C.; Tveitstol, T.; Haraldsen, I.; Hawellek, D.; Hipp, J.; Engemann, D.

10.1101/2025.04.15.648903 — neuroscience — Posted on 2025-04-20

1921 Dynamic Pathway of Guanidine-III Riboswitch Folding Revealed by Single-Molecule FRET: Mg2+-Assisted Preorganization and Ligand-Induced Kinetic Trapping

Jiang, M.; Bian, Y.; Zou, L.; Liu, T.; Ji, Z.; Ren, W.; Guo, Z.; Cao, Y.; Jiao, Y.; Pan, H.

10.1101/2025.04.15.648854 — biophysics — Posted on 2025-04-20

1922 Topography Aware Optimal Transport for Alignment of Spatial Omics Data

Ceccarelli, F.; Lio, P.; Saez-Rodriguez, J.; Holden, S. B.; Tanevski, J.

10.1101/2025.04.15.648894 — bioinformatics — Posted on 2025-04-20

1923 Accelerated, Accurate, Hybrid Short and Long Reads Alignment and Variant Calling

Hu, J.; Freed, D.; Feng, H.; Chen, H.; Li, Z.; Chen, H.

10.1101/2025.04.15.648987 — bioinformatics — Posted on 2025-04-20

1924 Harmonizing Heterogeneous Single-Cell Gene Expression Data with Individual-Level Covariate Information

Mu, Y.; Li, W. V.

10.1101/2025.04.15.649009 — bioinformatics — Posted on 2025-04-20

1925 Facilitating genome annotation using ANNEXA and long-read RNA sequencing

Hoffmann, N.; Besson, A.; Cadieu, E.; Lorthiois, M.; Le Bars, V.; Houel, A.; Hitte, C.; Andre, C.; Hedan, B.; Derrien, T.

10.1101/2025.04.16.648718 — bioinformatics — Posted on 2025-04-20

1926 Fast and accessible morphology-free functional fluorescence imaging analysis

Estrada Berlanga, A. A.; Kang, G.; Kwok, A.; Broggini, T.; Lawlor, J.; Kuchibhotla, K.; Kleninfeld, D.; Mishne, G.; Charles, A.

10.1101/2025.04.15.648462 — bioinformatics — Posted on 2025-04-20

1927 A comprehensive pipeline for genome annotation across species: a case study on Schmidtea mediterranea

Zaremba, A.; Marszalek-Zenczak, M.; Dutta, A.; Samelak-Czajka, A.; Jackowiak, P.

10.1101/2025.04.16.649076 — bioinformatics — Posted on 2025-04-20

1928 Cold Quad-Modal Nanocomplex for Precise and Quantitative in Vivo Stem Cell Tracking

Shakeri-Zadeh, A.; Wang, C.; Kuddannaya, S.; Yousf, S.; Bulte, J.

10.1101/2025.04.16.649154 — bioengineering — Posted on 2025-04-20

1929 Extraordinary activation of CALB by alkylammonium ions: a new paradigm for activity enhancement of enzymes

Rangasamy, S.; Baby, E. K.; Kinsella, G. K.; Nolan, K.; Ryan, B. J.; Henehan, G. T. M.

10.1101/2025.04.18.649601 — bioengineering — Posted on 2025-04-20

1930 Single-molecule microscopy reveals that TFIIE subunits dynamically interact with preinitiation complexes in a manner controlled by TFIIH

Archuleta, S. R.; Miller, R. C.; Mirita, J. A.; Goodrich, J. A.; Kugel, J. F.

10.1101/2025.04.19.649533 — biochemistry — Posted on 2025-04-20

1931 Plasma membrane transbilayer asymmetry of PI(4,5)P2 drives unconventional secretion of Fibroblast Growth Factor 2

Kaur, M.; Lolicato, F.; Nickel, W.

10.1101/2025.04.19.649664 — biochemistry — Posted on 2025-04-20

1932 Tandem Mass Tag-Based High-Resolution LC-MS/MS identifies free D-aspartate-induced expression of proteins linked to schizophrenia and autism spectrum disorder

Errico, F.; Russo, R.; Carrillo, F.; Nuzzo, T.; di Vito, R.; Canonico, E.; Pedone, P. V.; Di Cunto, F.; Esposito, T.; Usiello, A.; Chambery, A.

10.1101/2025.04.18.649487 — biochemistry — Posted on 2025-04-20

1933 Allosteric modulation of dimeric GPR3 by ligands in the dimerization interface

Qiu, Z.; Wang, W.; Nie, Y.; Lin, J.; Zhang, B.; Xing, H.; Zheng, S.

10.1101/2025.04.19.649678 — biochemistry — Posted on 2025-04-20

1934 Annotation of 200 Insect Genomes with BRAKER for Consistent Comparisons across Species

Saenko, S.; Hoff, K. J.; Stanke, M.

10.1101/2025.04.17.649312 — genomics — Posted on 2025-04-20

1935 Cell type-specific epigenomic variation and its association with genotype in the human breast

Hauduc, A.; Steif, J.; Bilenky, M.; Moksa, M. M.; Cao, Q.; Ding, S.; Eaves, C. J.; Hirst, M.

10.1101/2025.04.16.648998 — genomics — Posted on 2025-04-20

1936 Comparison of Three Next Generation Sequencers on Their Basecall Error Rates and Bias Patterns

Yao, T.

10.1101/2025.04.15.649007 — genomics — Posted on 2025-04-20

1937 The hidden life of Xylella: Mining the NCBI Sequence Read Archive reveals potential new species, host plants and infected areas for this elusive bacterial plant pathogen

Briand, M.; Jacques, M.-A.; Dittmer, J.

10.1101/2025.04.18.649540 — genomics — Posted on 2025-04-20

1938 Stronger population suppression by gene drive targeting doublesex from dominant female-sterile resistance alleles

Chen, W.; Wang, Z.; Champer, J.

10.1101/2025.04.16.649134 — genetics — Posted on 2025-04-20

1939 First record of a second invasive soft coral species, Latissimia ningalooensis, in southern Puerto Rico

Toledo-Rodriguez, D. A.; McFadden, C. S.; Jimenez Marrero, N. M.; Munoz-Maravilla, J. D.; Veglia, A. J.; Weil, E. F.; Schizas, N. V.

10.1101/2025.04.16.648000 — ecology — Posted on 2025-04-20

1940 Genome-wide mapping of mesoscale neuronal RNA organization and condensation

Becker, L. A.; Quinodoz, S. A.; Comi, T. J.; Kimchi, O.; Knowles, D. A.; Brangwynne, C. P.

10.1101/2025.04.19.649570 — molecular biology — Posted on 2025-04-20

1941 Aging alters mRNA processing in the mouse ovary

Vo, K.; Pei, G. J.; Thiyagarajan, R.; Fields, P. E.; Rumi, M. A. K.

10.1101/2025.04.16.649248 — molecular biology — Posted on 2025-04-20

1942 Multiomics approach identifies SERPINB1 as candidate progression biomarker for Spinocerebellar Ataxia type 2

Almaguer-Mederos, L. E.; Key, J.; Sen, N.-E.; Canet-Pons, J.; Doering, C.; Meierhofer, D.; Gispert-Sanchez, S.; Cuello-Almarales, D.; Almaguer-Gotay, D.; Osorio-Gonzalez, L. M.; Aguilera-Rodriguez, R.; Medrano-Montero, J.; Auburger, G.

10.1101/2025.04.18.649103 — molecular biology — Posted on 2025-04-20

1943 The 4th GPCR Dock: assessment of blind predictions for GPCR-ligand complexes in the era of AlphaFold

Chitsazi, R.; Wu, Y.; GPCR Dock 2021 participants, ; Stevens, R. C.; Zhao, S.; Kufareva, I.

10.1101/2025.04.18.647407 — molecular biology — Posted on 2025-04-20

1944 Integrated Multi-Omics Mapping of Mitochondrial Dysfunction and Substrate Preference in Barth Syndrome Cardiac Tissue

Schomakers, B. V.; Passadouro, A. S.; Tretowicz, M. M.; Simpson, P. J.; Jaspers, Y. R. J.; van Weeghel, M.; Hu, I. M.; Lamboo, C. M. E.; Cloutier, D.; Byrne, B. J.; van Klinken, J. B.; Janssens, P. M.; Piersma, S. R.; Jimenez, C. R.; Vaz, F. M.; Salomons, G. S.; van der Velden, J.; Houtkooper, R. H.; Mosegaard, S.

10.1101/2025.04.17.649294 — molecular biology — Posted on 2025-04-20

1945 VEGF-B/NRP1 Signaling Modulates Mitochondrial Homeostasis and Cardiac Function After Myocardial Infarction

Mukhopadhyay, D.; Varanasi, S. M.; Sabharwal, A.; Kar, R.; Magnano, C.; Dorairaj, A.; Wang, E.; Dutta, S. K.; Das, P.; Ekker, S. C.; Wang, Y.; Singh Angom, R.

10.1101/2025.04.18.649613 — molecular biology — Posted on 2025-04-20

1946 ANI-netID: a genome similarity-network based biological identification system

Nozawa, S.; Watanabe, K.

10.1101/2025.04.19.649685 — microbiology — Posted on 2025-04-20

1947 Pre-existing YFV-17D immunity mediates T cell cross-protection against DENV-2 infection

Tonto, P. B.; Gallon, S.; Alatrash, R.; Wang, W.-K.; Herrera, B. B.

10.1101/2025.04.16.649113 — immunology — Posted on 2025-04-20

1948 Antigen-scaffolds loaded with hyper-stable Neoleukin-2/15 expand antigen-specific T cells with a favorable phenotype for adoptive cell therapy

Ormhoej, M.; Munk, K. K.; Tvingsholm, S.; Ramanathan, K.; Bentzen, A. K.; Kladis, G.; Aasbjerg, G. N.; Nos, G.; Tamhane, T.; Halldorsdottir, H. R.; Nybo, S.; Frej, M. S.; Johansen, K. H.; Kadivar, M.; Hadrup, S. R.

10.1101/2025.04.16.649086 — immunology — Posted on 2025-04-20

1949 Metabolic Reprogramming of Pathogenic CD4+ T Helper Cells Attenuates Inflammatory Bowel Disease Pathogenesis

Mishra, S. K.; Abdelrahman, L. M.; Davidson, H. M.; Kim Lee, H. S.; Valenzuela-Perez, L.; Hassan, O. M.; Faubion, W. A.; Hirsova, P.; Bamidele, A. O.

10.1101/2025.04.15.649047 — immunology — Posted on 2025-04-20

1950 Unveiling the Molecular Architecture of T Cells and Immune Synapses with Cryo-Expansion Microscopy

Lemaitre, F.; Mercey, O.; Mean, I.; Paulin, E.; Dutoit, V.; Rath, J.; Migliorini, D.; Arber, C.; Guichard, P.; HAMEL, v.; Wolf, B.

10.1101/2025.04.15.648816 — immunology — Posted on 2025-04-20

1951 Real-world objects scaffold visual working memory for features: Increased neural delay activity when colors are remembered as part of meaningful objects

Chung, Y. H.; Brady, T. F.; Stoermer, V. S.

10.1101/2025.04.15.645785 — neuroscience — Posted on 2025-04-20

1952 Latent dimensions in neural representations predict choice context effects

Madar, A.; Zemer, T.; Tavor, I.; Levy, D. J.

10.1101/2025.04.15.648989 — neuroscience — Posted on 2025-04-20

1953 Identifying discriminative EEG features of Unsuccessful and Successful stopping during the Stop Signal Task

Skaug, K. A.; Leonardsen, E. H.; Huster, R. J.

10.1101/2025.04.15.648695 — neuroscience — Posted on 2025-04-20

1954 Whole-brain EEG dynamics depending on the stimulus modality and task requirements in oddball tasks

Kashihara, S.; Asai, T.; Imamizu, H.

10.1101/2025.04.15.648394 — neuroscience — Posted on 2025-04-20

1955 Improved Injury Detection Through Harmonizing Multi-Site Neuroimaging Data after Experimental TBI: A Translational Outcomes Project in NeuroTrauma (TOP-NT) Consortium Study

Kislik, G.; Fox, R.; Korotcov, A. V.; Zhou, J.; Febo, M.; Moghadas, B.; Bibic, A.; Zou, Y.; Wan, J.; Koehler, R. C.; Adebayo, T.; Burns, M. P.; McCabe, J. T.; Wang, K. K.; Huie, J. R.; Ferguson, A. R.; Harris, N. G.; The TOP-NT Investigators,

10.1101/2025.04.15.649026 — neuroscience — Posted on 2025-04-20

1956 Cocaine-induced immediate-early gene expression in the nucleus accumbens: roles of separate cAMP sensors

Zhang, H.-Y.; Salman, T.; Bi, G.-H.; Jiang, S. Z.; Gerfen, C. R.; Lutas, A.; Xu, W.; Xi, Z.-X. `; Eiden, L. E.

10.1101/2025.04.15.648980 — neuroscience — Posted on 2025-04-20

1957 Linking neuron-axon-synapse architecture to white matter vasculature using high-resolution multimodal MRI in primate brain

Kimura, I.; Hayashi, T.; Autio, J. A.

10.1101/2025.04.15.648990 — neuroscience — Posted on 2025-04-20

1958 Host-specific platelet-activating factor acetylhydrolase selectively remodels diacylglycerophospholipids to control schistosome development

Ertl, J.; Prodjinotho, U. F.; Rao, Z.; Anisuzzaman, A.; Schluckebier, J.; Hamway, Y.; Baar, P.; Haslbeck, M.; Grevelding, C. G.; Haeberlein, S.; Falcone, F. H.; Schulz, S.; Koeberle, A.; Prazeres da Costa, C.

10.1101/2025.04.16.649075 — systems biology — Posted on 2025-04-20

1959 Photosynthesis regulation impacts carbon and nitrogen assimilation in the diazotrophic cyanobacterium Anabaena sp. PCC 7120

Santin, A.; Storti, M.; Mezzavilla, M.; Fortunato, A.; Arcudi, F.; Flores, E.; Morosinotto, T.; Perin, G.

10.1101/2025.04.16.649060 — plant biology — Posted on 2025-04-20

1960 Developmentally-controlled generation of tRNA halves facilitates translational repression during sexual reproduction

Juarez-Gonzalez, V. T.; Marquez-Molins, J.; Cheng, J.; Reig-Valiente, J. L.; Kutashev, K.; Rosa, S.; Martinez, G.

10.1101/2025.04.15.648877 — plant biology — Posted on 2025-04-20

1961 A tRNA-gRNA multiplexing system for CRISPR genome editing in Marchantia polymorpha.

Frangedakis, E.; Yelina, N.; Eeda, S. K.; Romani, F.; Fragkidis, A.; Haseloff, J.; Hibberd, J.

10.1101/2025.04.18.649274 — plant biology — Posted on 2025-04-20

1962 Brain-derived exosome biomarkers of neuroinflammation and neuronal functional iron deficiency in newborns of overweight-obese mothers

Tran, P. V.; Harris, A. C.; Maxim, Z. L.; Munirathinam, M.; Muelken, P.; Javadova, N.; Kruttiventi, S.; Kling, P. J.; Baack, M. L.; Georgieff, M. K.

10.1101/2025.04.15.648967 — physiology — Posted on 2025-04-20

1963 HUMAN FETAL CIRCULATING FACTORS FROM PREGNANCIES COMPLICATED BY MATERNAL OBESITY INDUCE HYPERTROPHY IN NEONATAL RAT CARDIOMYOCYTES

Vaughan, O. R.; Goodspeed, A.; Sucharov, C. C.; Powell, T. L.; Jansson, T.

10.1101/2025.04.16.649071 — physiology — Posted on 2025-04-20

1964 Oxytocin may reduce the accumulation and effects of chronic stress: An exploratory study using hair samples

Ochi, G.; Ohara, N.; Kameo, H.

10.1101/2025.04.15.649015 — physiology — Posted on 2025-04-20

1965 A Single-Cell Atlas Of Human Pediatric Liver Reveals Age-Related Hepatic Gene Signatures

10.1101/2025.04.16.649149 — genomics — Posted on 2025-04-20

1966 A co-speciation dilemma and a lifestyle transition with genomics consequences in Wolbachia of Neotropical Drosophila

Papachristos, K.; Miller, W. J.; Klasson, L.

10.1101/2025.04.16.649125 — genomics — Posted on 2025-04-20

1967 Dissociating the functional role of the para-hippocampal and the parietal cortex in human multi-step reinforcement learning

Cerrotti, F.; Salvador, A.; Hamroun, S.; Lebreton, M.; Palminteri, S.

10.1101/2025.04.15.648746 — neuroscience — Posted on 2025-04-20

1968 The crosstalk between the anterior hypothalamus and the locus coeruleus during wakefulness is associated with low frequency oscillations power during sleep

Mortazavi, N.; Talwar, P.; Koshmanova, E.; Sharifpour, R.; Beckers, E.; Paparella, I.; Balda, F.; Bastin, C.; Collette, F.; Lamalle, L.; Phillips, C.; Zubkov, M.; Vandewalle, G.

10.1101/2025.04.15.647930 — neuroscience — Posted on 2025-04-20

1969 Neural oscillations and top-down connectivity are modulated by object-scene congruency

Gu, Y.; Krugliak, A.; Clarke, A.

10.1101/2025.04.15.648958 — neuroscience — Posted on 2025-04-20

1970 Value coding by primate amygdala neurons complies with economic choice theory

Grabenhorst, F.; Schultz, W.; Ferrari-Toniolo, S.

10.1101/2025.04.15.648888 — neuroscience — Posted on 2025-04-20

1971 Development of a 24-Channel 3T Phased-Array Coil for fMRI in Awake Monkeys - Mitigating Spatiotemporal Artifacts in Ferumoxytol-Weighted Functional Connectivity Estimation

Autio, J. A.; Yoshida, A.; Kawabata, Y.; Ohno, M.; Nishigori, K.; Ose, T.; Smith, S. M.; Van Essen, D. C.; Glasser, M. F.; Hayashi, T.

10.1101/2025.04.15.648822 — neuroscience — Posted on 2025-04-20

1972 Eye movements of younger and older adults decrease during story listening in background noise

Herrmann, B.; Scharf, F.; Widmann, A.

10.1101/2025.04.15.648919 — neuroscience — Posted on 2025-04-20

1973 Pathological Mechanisms of Motor Dysfunction in Familial Danish Dementia: Insights from a Knock-In Rat Model

Choudhury, A.; Yesiltepe, M.; Lashley, T.; Singh, V.; Yin, T.; Fernandez, A.; D'Adamio, L.; Ahn, H. J.

10.1101/2025.04.15.649002 — neuroscience — Posted on 2025-04-20

1974 A polymeric, PDMS-based large-scale skull replacement suitable for optical and mechanical access for long-term neuronal imaging, electrophysiology, and optogenetics

Takahashi, K.; Huis in 't Veld, G. J.; Benedetti, D.; Wang, J.-Y.; Pontes Quero, S.; Yuste, R.; Pennartz, C. M. A.; Olcese, U.

10.1101/2025.04.15.648966 — neuroscience — Posted on 2025-04-20

1975 The superficial tufted and mitral cell output neurons of the mouse olfactory bulb have a dual role in insulin sensing

Kolling, L. J.; Marcinkiewcz, C.; Fadool, D. A.

10.1101/2025.04.15.648999 — neuroscience — Posted on 2025-04-20

1976 Electrochemical Metabolic Profiling Reveals Mitochondrial Hyperactivation and Enhanced Neural Progenitor Proliferation in MLC1-Mutant Human Cortical Organoids

Koo, K.-M.; Choi, J.-S.; Nam, Y.-K.; Kim, H.-J.; Kim, C.-D.; Jeong, S.-H.; Jang, H.-J.; Lim, K.; Lim, B.-C.; Kim, T.-H.; Cho, K.-O.

10.1101/2025.04.16.647364 — neuroscience — Posted on 2025-04-20

1977 Survey of hippocampal responses to sound in naive mice reveals widespread activation by broadband noise onsets

Bigelow, J.; Suzuki, T.; Wu, Y.; Hu, Y.; Hasenstaub, A. R.

10.1101/2025.04.15.649017 — neuroscience — Posted on 2025-04-20

1978 Circadian-Related Dynamics of the Endocannabinoid System in Male Mouse Brain

Farfara, D.; Lewitus, G. M.; Korin, B.; Hajjo, H.; Feder, C. L.; Sulimani, L.; Berman, P.; Procaccia, S.; Azulay-Debby, H.; Meiri, D.

10.1101/2025.04.15.648929 — neuroscience — Posted on 2025-04-20

1979 Cellular and Extracellular microRNA Dysregulation in LRRK2-Linked Parkinson's Disease

Knab, F.; Lee, J.-H.; Nirujogi, R.; Menden, K.; Busra Isik, F.; Rajkumar, A. P.; Czemmel, S.; Fitzgerald, J.; Gasser, T.

10.1101/2025.04.15.648997 — neuroscience — Posted on 2025-04-20

1980 Distinct impacts of sodium channel blockers on the strength-duration properties of human motor cortex neurones

Rocchi, L.; Brown, K.; Di Santo, A.; Smith, H.; Peterchev, A. V.; Rothwell, J. C.; Hannah, R.

10.1101/2025.04.16.648964 — neuroscience — Posted on 2025-04-20

1981 Temporal-orbitofrontal pathway regulates choices across physical reward and visual novelty

Ogasawara, T.; Xu, K.; Snyder, A. Z.; Perlmutter, J. S.; Tu, Z.; Minamimoto, T.; Inoue, K.-i.; Takada, M.; Monosov, I. E.

10.1101/2025.04.15.648986 — neuroscience — Posted on 2025-04-20

1982 D3 dopamine receptors implicate a subtype of medium spiny neuron in the aversive effects of antipsychotic medications

Lewis, E.; Muir, J.; Li, L. C.; Glienke, J.; Gooding, S. W.; Bender, K.; Kim, C.; Whistler, J.

10.1101/2025.04.15.649037 — neuroscience — Posted on 2025-04-20

1983 Single electrically induced epileptic afterdischarge triggers synaptic weakening, AMPA receptor endocytosis and shrinkage of dendritic spines in the hippocampus

Crestani, A. P.; Zacharias, L. R.; Marques, D. B.; Fonseca, F. F. F.; Ruggiero, R. N.; Leite, J. P.

10.1101/2025.04.15.649044 — neuroscience — Posted on 2025-04-20

1984 In the words of others: ERP evidence of speaker-specific phonological prediction

Sala, M.; Vespignani, F.; Gastaldon, S.; Casalino, L.; Peressotti, F.

10.1101/2025.04.16.648895 — neuroscience — Posted on 2025-04-20

1985 Multimodal approach to characterize surgically removed epileptogenic zone from patients with focal drug-resistant epilepsy: from operating room to wet lab

Kyyriainen, J.; Della Pietra, A.; Torkamani-Azar, M.; Gomez- Budia, M.; Novosolova, N.; Eronen, H.; Narvaez, O.; Paasonen, E.; Lezhneva, V.; Pelkonen, A.; Saveleva, L.; Huotarinen, A.; Jutila, L.; Rauramaa, T.; Immonen, A.; Leinonen, V.; Tohka, J.; Grohn, O.; Kalviainen, R.; Malm, T.; Sierra, A.

10.1101/2025.04.15.648977 — neuroscience — Posted on 2025-04-20

1986 Toward Unified Biomarkers for Focal Epilepsy

Wang, S. H.; Ferrari, P.; Arnulfo, G.; Marzulli, M.; Degras, D.; Myrov, V.; Palva, S.; Nobili, L.; Ciuciu, P.; Palva, M.

10.1101/2025.04.15.647522 — neuroscience — Posted on 2025-04-20

1987 Large-scale single-neuron recording using the uFINE array in human cortex

Wu, S.; Yan, Z.; Kong, C.; Li, X.; Dong, Q.; Qian, Y.; Chen, G.; Chen, B.; Ren, C.; Lu, J.; Zhao, Z.; Jiang, X.; Li, X.

10.1101/2025.04.14.648657 — bioengineering — Posted on 2025-04-20

1988 Development of Replay-DMN Coordination Predicts Entorhinal Grid Codes

Pang, L.; Qu, Y.; Ou, J.; Wu, S.; Luo, Y.; Gohil, C.; Woolrich, M.; Behrens, T.; Liu, Y.

10.1101/2025.04.02.646732 — neuroscience — Posted on 2025-04-20

1989 In vivo mRNA delivery to the lung vascular endothelium by dicationic Charge-Altering Releasable Transporters

AbdElwakil, M.; Ni, J.; Ramsay-Burrough, S.; Hurst, P. J.; McClellan, R.; Khasnavis, S. R.; Jia, Y.; Masud, S. R.; Blake, T. R.; Sallets, A.; Haabeth, O.; Sagiv-Barfi, I.; Czerwinski, D. K.; Levy, R.; Wender, P. A.; Kumar, M. E.; Waymouth, R. M.

10.1101/2025.04.19.649649 — bioengineering — Posted on 2025-04-19

1990 Large-scale identification of microsatellite loci from multiple otter (Mammalia, Carnivora, Lutrinae) species using whole genome sequence data

de Ferran, V.; Chua, C. E. E.; Johns, P.; Eizirik, E.; Koepfli, K.-P.

10.1101/2025.04.14.648774 — genomics — Posted on 2025-04-19

1991 Theobromine is Associated with Slower Epigenetic Ageing

Saad, R.; Costeira, R.; Matias Garcia, P.; Gieger, C.; Suhre, K.; Peters, A.; Kastenmuller, G.; Rodriguez Mateos, A.; Dias, C.; Menni, C.; Waldenberger, M.; Bell, J. T.

10.1101/2025.04.15.648884 — genetics — Posted on 2025-04-19

1992 Phylogenomic analyses of all major sea cucumber lineages provide a robust backbone of Holothuroidea

Whelpley, J. M.; Uehling, A. T.; Paulay, G.; Ryan, J. F.

10.1101/2025.04.14.648730 — evolutionary biology — Posted on 2025-04-19

1993 Sub-lethal pesticide exposure facilitates the potential northward range shifts of ticks by increasing cold tolerance and overwintering survival

Oyen, K. J.; Barya, T.; Davies, B.; Didion, E. M.; Benoit, J. B.

10.1101/2025.04.14.648794 — ecology — Posted on 2025-04-19

1994 Contralateral Prefrontal and Network Engagement during Left DLPFC 10 Hz rTMS: An Interleaved TMS-fMRI Study in Healthy Adults

van Hattem, T.; Chang, K.-Y.; Tik, M.; Taylor, P.; Bjorklund, J.; Bulubas, L.; Padberg, F.; Keeser, D.; Campana, M.

10.1101/2025.04.14.648588 — neuroscience — Posted on 2025-04-19

1995 Ploidy variation modulates outbreeding response and promotes mating system evolution in a selfing plant lineage.

Olmedo-Castellanos, C.; Garcia-Munoz, A.; Ferron, C.; Bakkali, M.; Munoz-Pajares, A. J.; Abdelaziz, M.

10.1101/2025.04.15.648901 — plant biology — Posted on 2025-04-19

1996 Single and Multiple Buds Form characteristics in Amorphophallus muelleri

Liu, Y.; Li, Z.; He, J.; Li, W.; Xie, Y.; Ge, S.; Wang, R.; Wu, X.

10.1101/2025.04.14.648843 — physiology — Posted on 2025-04-19

1997 Mechanistic Insight of Tardigrade Anhydrobiosis via Protein Structural Analysis

Zhang, C.

10.1101/2025.04.14.648834 — biophysics — Posted on 2025-04-19

1998 Lenacapavir-induced Lattice Hyperstabilization is Central to HIV-1 Capsid Failure at the Nuclear Pore Complex and in the Cytoplasm

Hudait, A.; Burdick, R. C.; Bare, E. K.; Pathak, V. K.; Voth, G. A.

10.1101/2025.04.18.649524 — biophysics — Posted on 2025-04-19

1999 MegaPX: fast and space-efficient peptide assignment method using IBF-based multi-indexing

Lutfi, A.; Holstein, T.; Andreotti, S.; Muth, T.

10.1101/2025.04.14.648734 — bioinformatics — Posted on 2025-04-19

2000 Parageobacillus thermoglucosidasius and the reductive glycine pathway: A journey of Almosts and Maybes.

Paredes Barrada, M.; Donati, S.; van Kranenburg, R.; Claassens, N. J.

10.1101/2025.04.15.648870 — bioengineering — Posted on 2025-04-19

2001 Large-scale single-neuron recording using the uFINE array in human cortex

Wu, S.; Yan, Z.; Kong, C.; Li, X.; Dong, Q.; Qian, Y.; Chen, G.; Chen, B.; Ren, C.; Lu, J.; Zhao, Z.; Jiang, X.; Li, X.

10.1101/2025.04.14.648657 — bioengineering — Posted on 2025-04-19

2002 γ-Secretase-mediated endoproteolysis of neuregulin-1 and E-cadherin

Malvankar, S. R.; Wolfe, M. S.

10.1101/2025.04.19.649652 — biochemistry — Posted on 2025-04-19

2003 Distinct mechanisms underlying extrachromosomal telomere DNA generation in ALT cancers

Lee, J.; Sohn, E. J.; Lee, J.; Taglialatela, A.; Ciccia, A.; Min, J.

10.1101/2025.04.15.648952 — biochemistry — Posted on 2025-04-19

2004 Single-Cell Multimodal Profiling Highlights Persistent Aortic Smooth Muscle Cell Changes in Diabetic Mice Despite Glycemic Control

Tanwar, V. S.; Malek, V.; Wang, J.; Luo, Y.; Malhi, N. K.; Zhang, H.; Abdollahi, M.; Lanting, L.; Senapati, P.; Das, S.; Reddy, M. A.; Zang, C.; Miller, C. L.; Chen, Z. B.; Natarajan, R.

10.1101/2025.04.14.648851 — biochemistry — Posted on 2025-04-19

2005 BACE1 regulates sleep-wake cycle through both enzymatic and non-enzymatic actions.

10.1101/2025.04.17.648898 — animal behavior and cognition — Posted on 2025-04-19

2006 Heat-mediated manipulation of gene expression by IR-LEGO in the developing genitalia in Drosophila

Takahashi, A.; Onuma, M.; Kumagai, T.; Hayashi, K.; Kamei, Y.

10.1101/2025.04.14.648785 — genetics — Posted on 2025-04-19

2007 RNase H1 counteracts DNA damage and ameliorates SMN-dependent phenotypes in a Drosophila model of Spinal Muscular Atrophy

Scatolini, L.; Graziadio, L.; Guerrini, D.; Maccallini, P.; Marino, C.; di Vito, R.; Hassan, A.; Grimaldi, M.; Fidaleo, M.; Dehghannasiri, R.; Proietti, G.; Piergentili, R.; Salvati, E.; Cacchione, S.; De Pitta, C.; Doksani, Y.; D'Ursi, A. M.; Wakefield, J.; Chen, L.; Gatti, M.; Colantoni, A.; Usiello, A.; Raffa, G. D.

10.1101/2025.04.17.649348 — genetics — Posted on 2025-04-19

2008 L-2-hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression

Gu, W.; Wang, X.; Solmonson, A.; Cai, L.; Tasdogan, A.; Franklin, J.; Zhang, Y.; Zhang, H.; Westfall, A. K.; Rowe, A.; Trivedi, H.; Faubert, B.; Wu, Z.; Sudderth, J.; Zacharias, L. G.; Afroze, B.; Bezprozvanny, I.; Sudarshan, S.; Cai, F.; McBrayer, S. K.; Mathews, T. P.; DeBerardinis, R. J.

10.1101/2025.04.16.649033 — genetics — Posted on 2025-04-19

2009 Vertical transmission of Wolbachia bypassing the germ line in an aphid

Nozaki, T.; Kobayashi, Y.; Shigenobu, S.

10.1101/2025.04.14.648810 — evolutionary biology — Posted on 2025-04-19

2010 Early warning signals do not predict a warming-induced experimental epidemic

Jarvis-Cross, M.; Kirk, D.; Krichel, L.; Luijckx, P.; Molnar, P.; Krkosek, M.

10.1101/2025.04.14.648789 — ecology — Posted on 2025-04-19

2011 Native species of the Atlantic Forest for urban environments based on functional groups: an approach to make cities in southern Brazil more resilient

Kanieski, M. R.; Fockink, G. D.; Zangalli, C.; Gomes, J. P.; Milani, J. E. d. F.; Mondin, C.; Paquette, A.

10.1101/2025.04.14.648749 — ecology — Posted on 2025-04-19

2012 A more-than-human political ecology of Indonesian songbird trade

Fiennes, S. B.; Hardianto, N.; Anaswari, S. D.; Damayani, L.; Haryono, J.; Jackson, T.; Dwiyahreni, A. A.; Birchall, C.; Holmes, G.; Hassall, C.

10.1101/2025.04.15.648493 — ecology — Posted on 2025-04-19

2013 Effects of human microRNAs 100-5p, 192-5p, and 574-3p on proliferation, migration, and gene expression of human immortalized nasopharyngeal cells

Muller Coan, B. G.; Elgui de Oliveira, D.

10.1101/2025.04.14.648665 — molecular biology — Posted on 2025-04-19

2014 Intraspecific bacterial competition mediated by rapidly diversifying tailocin and prophage loci

Kauffman, S. J.; Awori, R. M.; Allwell, E. C.; Taylor, A.; Bashey, F.; Goodrich-Blair, H.

10.1101/2025.04.19.648921 — microbiology — Posted on 2025-04-19

2015 Exclusion Systems Preserve Host Cell Homeostasis and fitness, Ensuring Successful Dissemination of Conjugative Plasmids and Associated Resistance Genes

Couturier, A.; Fraikin, N.; Lesterlin, C.

10.1101/2025.04.18.649494 — microbiology — Posted on 2025-04-19

2016 Kynurenine and NAD+ Pathways are Associated with Macrophage Content and Polarization in Carotid Plaques

Teunis, C. J.; Zijlstra, L. F.; Levels, J. H. M.; Vinten, K. T.; Tretowicz, M. M.; Mol, B. M. M.; Sluimer, J. C.; Mokry, M.; Murphy, A. J.; Kroon, J.; Stroes, E. S.; De Kleijn, D.; Houtkooper, R. H.; Neele, A. E.; Hanssen, N. M.

10.1101/2025.04.14.648852 — immunology — Posted on 2025-04-19

2017 Adjuvant conditioning enhances neutrophil function while inducing a suppressive peritoneal macrophage phenotype

Boccia, T.; Fattori, V.; Deroco Veloso da Silva, M.; Asquith, N. L.; Pan, W.; Rogers, M. S.; Zanoni, I.; Cuenca, A.

10.1101/2025.04.15.648954 — immunology — Posted on 2025-04-19

2018 Gut Microbiome-derived Propionate Reprograms Alveolar MacrophagesMetabolically and Regulates Lung Injury Responses

Maruyama, D.; Doan, T. N. M.; Tian, X.; Liao, W.-I.; Chaki, T.; Matthay, M. A.; Prakash, A.

10.1101/2025.04.14.648797 — immunology — Posted on 2025-04-19

2019 Rapid Eye Movement Sleep Displays Distinct Fractal Dynamics Between Phasic and Tonic States

Lu, Y.; Wu, L.; Liu, J.; Li, Y.; Huai, Y.

10.1101/2025.04.14.648721 — neuroscience — Posted on 2025-04-19

2020 Predictive distractor processing relies on integrated proactive and reactive attentional mechanisms

Ferrante, O.; Jensen, O.; Hickey, C.

10.1101/2025.04.14.648706 — neuroscience — Posted on 2025-04-19

2021 Spatially convergent fMRI signatures of diabetes and male sex identify genetic vulnerabilities to accelerated brain aging

Chesebro, A. G.; Rohm, L. R.; Antal, B. B.; Weistuch, C.; Strey, H. H.; Ratai, E.-M.; Jones, D. T.; Mujica-Parodi, L. R.

10.1101/2025.04.14.648801 — neuroscience — Posted on 2025-04-19

2022 The cerebellar components of the human language network

Casto, C.; Small, H.; Poliak, M.; Tuckute, G.; Lipkin, B.; Wolna, A.; D'Mello, A. M.; Fedorenko, E.

10.1101/2025.04.14.645351 — neuroscience — Posted on 2025-04-19

2023 Hypertension-Induced Neurovascular and Cognitive Dysfunction at Single-Cell Resolution

Pacholko, A. G.; Schaeffer, S. M.; Santisteban, M. M.; Wang, G.; Racchumi, G.; Faraco, G.; Anrather, J.; Iadecola, C.

10.1101/2025.04.14.648770 — neuroscience — Posted on 2025-04-19

2024 Rapid learning and integration of artificial sensation

Senneka, S.; Dadarlat, M.

10.1101/2025.04.14.648830 — neuroscience — Posted on 2025-04-19

2025 Human nasal olfactory stem cell-derived extracellular vesicles improve the repair of rat nerves

Bonnet, M.; Seblani, M.; Witters, M.; Marqueste, T.; Jaloux, C.; Morando, P.; Decherchi, P.; Feron, F.; Guiraudie-Capraz, G.

10.1101/2025.04.14.648811 — neuroscience — Posted on 2025-04-19

2026 Online HD-tRNS over the right temporoparietal junction modulates social inference but not motor coordination

Moreau, Q.; Chamberland, V.; Moses, L.; Milanova, G.; Dumas, G.

10.1101/2025.04.14.648341 — neuroscience — Posted on 2025-04-19

2027 Embodied Singing: Dual Role of Interoception in Vocal Expertise and Musical Competence

Zamorano, A. M.; Haumann, N. T.; Ligato, D.; Maublanc, P.; Brattico, E.; Vuust, P.; Kleber, B.

10.1101/2025.04.14.648736 — neuroscience — Posted on 2025-04-19

2028 Hippocampal Representational Drift Persists in a Stable Multisensory Virtual Environment

Climer, J. R.; Davoudi, H.; Oh, J. Y.; Dombeck, D. A.

10.1101/2025.04.14.648740 — neuroscience — Posted on 2025-04-19

2029 Mechanical environment afforded by engineered polymer hydrogel critically regulates survival of neural stem cells transplanted in the injured spinal cord via Piezo1-mediated mechanotransduction

Park, H. H.; Kim, Y.; Jang, B. S.; Geniscan, S.; Hwang, D. H.; Seo, Y.; Jee, S.-A.; Seo, H. G.; Kim, H. S.; Einisadr, A.; Kim, H.-J.; Lee, S.; Kwon, S.; Kim, K. S.; Lee, K. I.; Lee, J. Y.; Park, J. M.; Kim, Y.-M.; Song, S.-C.; Kim, B. G.

10.1101/2025.04.15.648586 — neuroscience — Posted on 2025-04-19

2030 Transcriptomic analysis of mitohormesis associated with lifespan extension in Caenorhabditis elegans

Kim, J.; Garcia, G.; Dutta, N.; Higuchi-Sanabria, R.

10.1101/2025.04.15.648933 — systems biology — Posted on 2025-04-19

2031 Disrupted stemness and redox homeostasis in mesenchymal stem cells of neonates from mothers with obesity: implications for increased adiposity

Bellalta, S.; Pinheiro Machado, E.; Prins, J.; Plosch, T.; Casanello, P.; Faas, M.

10.1101/2025.04.14.648714 — physiology — Posted on 2025-04-19

2032 Prex1 controls glucose homeostasis by limiting glucose uptake and mitochondrial metabolism in liver through GEF-independent regulation of Gpr21

Chu, J. Y.; Tsonou, E.; Machin, P. A.; MacLellan-Gibson, K.; Roberts, A.; Chetwynd, S. A.; McCormack, A. T.; Stephens, J. C.; Benetti, E.; Kinsella, G. K.; Baker, D.; Hornigold, D. C.; Welch, H. C. E.

10.1101/2025.04.14.648781 — physiology — Posted on 2025-04-19

2033 Diversification dynamics of the Palaeozoic actinopterygian radiation

Flannery-Sutherland, J.; Henderson, S.; Fasey, S.; Giles, S.

10.1101/2025.04.14.648759 — paleontology — Posted on 2025-04-19

2034 From Decay to Rhythm: Sustained Biological Oscillators Require More Than Chemistry Alone

Wu, Y.; Sun, S.

10.1101/2025.04.15.648857 — biophysics — Posted on 2025-04-19

2035 Phosphorylation of Ser81 in human AGT reversibly inactivate enzyme function and mimics catalytic defects of certain PH1-causing mutations

Milosevic, S.; Cano, M.; Salido, E.; Mesa, N.; Pey, A. l.

10.1101/2025.04.14.648764 — biophysics — Posted on 2025-04-19

2036 Plasmodium Repetome: A mysterious space with a wealth of information

Hora, R.; Mishra, P. C.; Kaur, S.; Singh, K.; Kumar, V.; Behl, A.; Manhas, A.

10.1101/2025.04.14.647515 — bioinformatics — Posted on 2025-04-19

2037 HemeFinder: a Computational Predictor for Heme-Binding Sites in Proteins

Tiessler-Sala, L.; Fernandez-Diaz, R.; Marechal, J.-D.

10.1101/2025.04.14.648773 — bioinformatics — Posted on 2025-04-19

2038 mspms: A Comprehensive R Package and Graphic Interface for Multiplex Substrate Profiling by Mass Spectrometry Analysis

Bayne, C.; Hurysz, B.; Gonzalez, D. J.; O'Donoghue, A.

10.1101/2025.04.14.648679 — bioinformatics — Posted on 2025-04-19

2039 Estimating drivers of breast tissue transitions from normal to tumor state

Kumar, S.; Vindal, V.

10.1101/2025.04.14.648655 — bioinformatics — Posted on 2025-04-19

2040 Bulk-based hypothesis weighing to increase power in single-cell differential expression analysis

Germain, P.-L.; Robinson, M. D.

10.1101/2025.04.15.648932 — bioinformatics — Posted on 2025-04-19

2041 Covalent targeting leads to the development of LIMK1 isoform-selective inhibitors

Mandel, S.; Hanke, T.; Prendiville, N.; Baena-Nuevo, M.; Berger, L. M.; Farges, F.; Schwalm, M. P.; Berger, B. T.; Kraemer, A.; Elson, L.; Saraswati, H.; Azeez, K. R. A.; Dederer, V.; Mathea, S.; Corrionero, A.; Alfonso, P.; Keller, S.; Gstaiger, M.; Krause, D. S.; Mueller, S.; Roehm, S.; Knapp, S.

10.1101/2025.04.17.649341 — biochemistry — Posted on 2025-04-19

2042 Uncovering Superior Alleles and Genetic Loci for Yield-Related Traits in Mungbean (Vigna radiata L. Wilczek) Through Genome-Wide Association Study

Shahin Uz Zaman, M.; Iqbal, M. S.; Prodhan, A.; Alam, A. M.

10.1101/2025.04.15.648935 — genomics — Posted on 2025-04-19

2043 Before the Black Box

Perry, C. L.; Robin, C.

10.1101/2025.04.14.648839 — genomics — Posted on 2025-04-19

2044 Prevalent cross-cell type QTL trans-regulatory genetic effects impacting innate lymphoid cells in the small intestine

Xu, M.; Gosik, K.; Zhang, Y.; Ashenberg, O.; Li, C.; Li, H.; Liu, K.; Churchill, G. A.; Gatti, D. M.; Choi, K.; Philip, V.; Graham, D.; Dey, K. K.; Xu, H.; Xavier, R. J.; Regev, A.

10.1101/2025.04.16.649031 — genetics — Posted on 2025-04-19

2045 Prediction in trait-based ecology: global simulations of specific leaf area using a trait-based dynamic vegetation model

Langan, L.; Kattenborn, T.; Roemermann, C.; Scheiter, S.; Anders, T.; Wolf, S.; Dantas de Paula, M.; Hickler, T.

10.1101/2025.04.14.648688 — ecology — Posted on 2025-04-19

2046 Effects of Wastewater from a Desalination Plant on a Marine Grassland in Santa Maria, Villa Clara, Cuba

Borges Casas, C. C.; Hernandez Albernas, J.

10.1101/2025.04.14.648634 — ecology — Posted on 2025-04-19

2047 The effect of Shifts in Fish Community Structure on PCDD/F temporal variability in common guillemot (Baltic Sea)

Ammar, Y.; olsson, j.; Gorokhova, E.; Skold, M.; Faxneld, S.; Hentati-Sundberg, J.; Soerensen, A. L.

10.1101/2025.04.14.648406 — ecology — Posted on 2025-04-19

2048 Purinergic signalling and calcium dynamics: potential drivers in the onset of coordinated intestinal motility in human fetal development

Jevans, B.; Chanpong, A.; Peruzza, L.; Perin, S.; Cairns, B.; Tagdiwala, P.; Vanden Berghe, P.; Hennig, G. W.; McCann, C. J.

10.1101/2025.04.17.649306 — developmental biology — Posted on 2025-04-19

2049 Maternal obesity programs cardiac remodeling in offspring via epigenetic, metabolic, and immune dysregulations.

Philips, E. A.; Alharithi, Y.; Wilson, T. D.; Broberg, C.; Davis, B. A.; Koch, S.; Carbone, L.; Rubinstein, J.; Gurley, S. B.; Rugonyi, S.; Kumar, S.; Maloyan, A.

10.1101/2025.04.15.648971 — molecular biology — Posted on 2025-04-19

2050 In vitro model of human subcutaneous adipocyte spheroids for studying mitochondrial dysfunction and mitochondria activating compounds

Wagner, A.; Lautaoja-Kivipelto, J.; Pehkonen, K.; Hassinen, A.; Kuusela, M.; Röttger, L.; Herbers, E.; Ioannidou, A.; Mädler, S.; Rothenaigner, I.; Srinivasan, S.; Laasonen, S.; Rahman, M. T.; Elomaa, P.; Kortetjärvi, S.; Olsson, A.; Ukkola, O.; Hadian, K.; Mann, M.; Peltoniemi, H.; Pietiläinen, K. H.; Klingenspor, M.; Virtanen, K. A.; Hagberg, C. E.; Pirinen, E.

10.1101/2025.04.16.649074 — molecular biology — Posted on 2025-04-19

2051 Covalent anti-HIV compound that induces HIV-1 capsid multimerization and degradation decomposes the viral core

Nakamura, T.; Takamune, N.; Okumura, M.; Yasunaga, J.-i.; Sugiura, M.; Amano, M.

10.1101/2025.04.19.649630 — microbiology — Posted on 2025-04-19

2052 A Highly Potent Human Antibody Neutralizing All Serotypes of BK Polyomavirus

Esslinger, C.; Hillenbrand, M.; Weber, M.; Schmitt, S.; Eicher, B.; Seidenberg, J.; Rutkauskaite, J.; Stöckli, B.; Townsend, C.; Huynh-Do, U.; Schachtner, T.; Delbue, S.; Maeder, A.

10.1101/2025.04.14.648680 — immunology — Posted on 2025-04-19

2053 Mapping the spatiotemporal dynamics of de novo protein synthesis during long-term memory formation

Evans, H. T.; Adler, D.; Selles, M. C.; Kalavai, S. V.; Yu, A.; Wu, V.; Denil, E.; Golhan, E. N.; Polavarapu, A.; Balamoti, E.; Chao, M. V.; Froemke, R. C.; Klann, E.

10.1101/2025.04.17.649250 — neuroscience — Posted on 2025-04-19

2054 Three cortical streams for somatosensory information processing

Niu, M.; Froudist-Walsh, S.; Hou, Y.; Rapan, L.; Vincon, N.; Kennedy, H.; Xu, T.; Palomero-Gallagher, N.

10.1101/2025.04.14.647517 — neuroscience — Posted on 2025-04-19

2055 Newly trained navigation and verbal memory skills elicit changes in task-related networks but not brain structure

Zheng, L.; Boogaart, Z.; McAvan, A.; Garren, J.; Doner, S.; Wilkes, B. J.; Groves, W.; Yuksel, E.; Cherep, L.; Ekstrom, A.; Weisberg, S. M.

10.1101/2025.04.14.648747 — neuroscience — Posted on 2025-04-19

2056 A neural circuit targeting technique for investigating functional input-output organization in the nervous system

Kasuga, Y.; Gu, X.; Ohnuki, T.; Uematsu, A.; Yoshida, R.; Yanagihara, D.; Johansen, J. P.

10.1101/2025.04.17.649280 — neuroscience — Posted on 2025-04-19

2057 Cardio-respiratory interactions in interoceptive perception: The role of heartbeat-modulated cortical oscillations

Zaccaro, A.; della Penna, F.; Bubbico, F.; Bayram, B.; Parrotta, E.; Perrucci, M. G.; Costantini, M.; Ferri, F.

10.1101/2025.04.14.648690 — neuroscience — Posted on 2025-04-19

2058 OpenIrisDPI: An Open-Source Digital Dual Purkinje Image Eye Tracker for Visual Neuroscience

Ressmeyer, R. A.; Otero-Millan, J.; Horwitz, G. D.; Yates, J.

10.1101/2025.04.18.649589 — neuroscience — Posted on 2025-04-19

2059 Few-shot learning for highly accelerated 3D time-of-flight MRA reconstruction

Li, H.; Chiew, M.; Dragonu, I.; Jezzard, P.; Okell, T. W.

10.1101/2025.04.14.648710 — neuroscience — Posted on 2025-04-19

2060 White matter geometry confounds Diffusion Tensor Imaging Along Perivascular Space (DTI-ALPS) measures

Schilling, K.; Newton, A. T.; Tax, C. M.; Nilsson, M.; Chamberland, M.; Anderson, A. W.; Landman, B. A.; Descoteaux, M.

10.1101/2025.04.14.648733 — neuroscience — Posted on 2025-04-19

2061 Dysregulation of neuronal activity-dependent immediate early genes in a mouse model of Angelman syndrome

Giri, B.; Das, S.; Jana, S.; Jana, N. R.

10.1101/2025.04.15.648865 — neuroscience — Posted on 2025-04-19

2062 Hemispheric Asymmetry of Tau Pathology is Related to Asymmetric Amyloid Deposition in Alzheimer's Disease

Anijarv, T. E.; Ossenkoppele, R.; Smith, R.; Pichet Binette, A.; Collij, L. E.; Behjat, H. H.; Rittmo, J.; Karlsson, L.; Ahmadi, K.; Strandberg, O.; the Alzheimer's Disease Neuroimaging Initiative, ; van Westen, D.; Vogel, J. W.; Stomrud, E.; Palmqvist, S.; Mattsson-Carlgren, N.; Spotorno, N.; Hansson, O.

10.1101/2025.04.15.648728 — neuroscience — Posted on 2025-04-19

2063 Bestrophin1-mediated GABA release activates large chloride currents to generate epileptiform events in the entorhinal cortex

Scalmani, P.; Uva, L. M.; Regondi, M. C.; Miele, C.; Grazioso, V.; de Curtis, M.

10.1101/2025.04.15.648911 — neuroscience — Posted on 2025-04-19

2064 Comprehensive Neural Representations of Naturalistic Stimuli through Multimodal Deep Learning

Fu, M.; Chen, G.; Zhang, Y.; Zhang, M.; Wang, Y.

10.1101/2025.04.15.646250 — neuroscience — Posted on 2025-04-19

2065 Anaesthesia disrupts mesoscale signal propagation in spite of enhanced responsivity in frontal but not in parietal cortex

Dwarakanath, A.; Khalili-Ardali, M.; Gay, M.; HV, R.; Roustan, M.; Dehaene, S.; Jarraya, B.; Panagiotaropoulos, T.

10.1101/2025.04.15.648923 — neuroscience — Posted on 2025-04-19

2066 EEG Signatures of Auditory Distraction: Neural Responses to Spectral Novelty in Real-World Soundscapes

Korte, S.; Haupt, T.; Bleichner, M. G.

10.1101/2025.04.14.648656 — neuroscience — Posted on 2025-04-19

2067 Targeted degradation of α-synuclein prevents PFF-induced aggregation

Carton, B.; Gelders, G.; Sathe, G.; Kocaturk, N.; Roth, S.; Macartney, T.; Van elsen, J.; De Muynck, L.; Buist, A.; Moechars, D.; Sapkota, G. P.

10.1101/2025.04.15.648905 — neuroscience — Posted on 2025-04-19

2068 An integrated landscape of mRNA and protein isoforms

Kedan, A.; Zauber, H.; Wang, M.-R.; Zhu, Q.; Fang, L.; Chen, W.; Selbach, M.

10.1101/2025.04.16.648713 — systems biology — Posted on 2025-04-19

2069 Age deceleration and reversal gene patterns in dauer diapause

Totska, K.; Barata, J. C. V. V.; Sandt, W.; Meyer, D. H.; Schumacher, B.

10.1101/2025.04.14.648662 — systems biology — Posted on 2025-04-19

2070 Transcriptional competition biases the effects of second messengers in E. coli

Ripamonti, A.; Lacassin, M.; Droghetti, R.; Bokinsky, G.; Cosentino Lagomarsino, M.

10.1101/2025.04.15.648722 — systems biology — Posted on 2025-04-19

2071 A new method to quantify the spatiotemporal localization of SnRK1.1

Brugnara, C. B.; Diaz, M. C.; Bultri, J.; Liebsch, D.; Hita, F.; Aguilar, D.; Fusari, C. M.; Dengjel, J.; Levi, V.; Blanco, N. E.

10.1101/2025.04.14.648863 — plant biology — Posted on 2025-04-19

2072 Photodisruption of the inner limiting membrane promotes retinal engraftment of stem-cell derived retinal ganglion cells

De Coster, E.; De Clerck, K.; De Clercq, C.; Li, W.; Punj, D.; Vanmeerhaeghe, B.; De Smedt, S.; Braeckmans, K.; Hadady, H.; Remaut, K.; Johnson, T. V.; Peynshaert, K.

10.1101/2025.04.14.648093 — pharmacology and toxicology — Posted on 2025-04-19

2073 Interleukin-6 is critical in the development of gcn2-mutation associated pulmonary vascular disease in mice

Schwiening, M.; Gao, Q.; Southwood, M.; Crosby, A.; Moore, S.; Valer, J. A.; Veale, N.; Dunmore, B.; Upton, P. D.; Thompson, R.; Morrell, N.; Marciniak, S. J.; Soon, E.

10.1101/2025.04.14.648729 — pathology — Posted on 2025-04-19

2074 THLANet: A Deep Learning Framework for Predicting TCR-pHLA Binding in Immunotherapy Applications

Long, X.; Yang, Q.; Dong, W.; Li, X.; Wang, K.; Dong, S.; Luo, G.; Zhang, X.; Yang, T.; Gao, X.; Wang, G.

10.1101/2025.04.14.648678 — bioinformatics — Posted on 2025-04-19

2075 TestNet: A Testing Method for Inferring Microbial Networks with False Discovery Rate Control, for Clustered and Unclustered Samples

Su, C.; He, M.; Van Doren, V. E.; Kelley, C. F.; Hu, Y.

10.1101/2025.04.14.648862 — bioinformatics — Posted on 2025-04-19

2076 Synthetic peptide hydrogels as a model of the bone marrow niche demonstrate efficacy of a combined CRISPR-CAR T-cell therapy for acute myeloid leukaemia

Doherty-Boyd, W. S.; Tsimbouri, M. P.; Jayawarna, V.; Walker, M.; Taqi, A. F.; Mahon, N.; Meek, D.; Young, P.; Miller, A.; West, A. G.; Salmeron-Sanchez, M. G.; Dalby, M.; Donnelly, H.

10.1101/2025.04.16.649170 — bioengineering — Posted on 2025-04-19

2077 Focused Ultrasound Crosslinkable Granular Hydrogels

Claxton, N. L.; He, E.; Bukovic, K.; Thim, E. A.; Letteri, R. A.; Caliari, S. R.; Price, R. J.; DeWitt, M. R.; Highley, C. B.

10.1101/2025.04.14.648397 — bioengineering — Posted on 2025-04-19

2078 The effect of fatty acid binding protein-3 exposure on endothelial transcriptomics

Nguyen, H. C.; Singh, A.; Castellani, C. A.; Qadura, M.; Singh, K. K.

10.1101/2025.04.16.649114 — biochemistry — Posted on 2025-04-19

2079 Huib32: A Potent and Selective USP32 Inhibitor Modulating Endosomal Processes and Advancing Cell-Permeable USP32 Probes

Scherpe, S.; Pol, V.; Kooij, R.; Pinto-Fernandez, A.; Tjokrodirijo, R. T. N.; O'Brien, D. P.; Vendrell, I.; Hameed, D. S.; van Veelen, P. A.; Kessler, B. M.; Geurink, P. P.; Sapmaz, A.

10.1101/2025.04.19.649632 — biochemistry — Posted on 2025-04-19

2080 Allocentric and egocentric cues constitute an internal reference frame for real-world visual search

Chen, Y.; Xu, Z.-X.

10.1101/2025.04.14.648618 — animal behavior and cognition — Posted on 2025-04-19

2081 An optogenetic toolkit for robust activation of FGF, BMP, and Nodal signaling in zebrafish

Iannucci, L. E.; Velanganni, S. M. T.; Murphy, M. R.; Donahue, C. E. T.; Anderson, W. K.; Rogers, C. E.; Saul, A. J.; Rogers, K. W.

10.1101/2025.04.17.649426 — developmental biology — Posted on 2025-04-19

2082 ISLET-1 knockdown causes abnormal peripheral axonal growth of mesencephalic trigeminal neurones in the chick embryo

Koumoundourou, E. A.; Pop, S.; Graham, A.; Wizenmann, A.

10.1101/2025.04.17.649275 — developmental biology — Posted on 2025-04-19

2083 Curvature induced patterns: A geometric, analytical approach to understanding a mechanochemical model

Nesenberend, D.; Doelman, A.; Veerman, F.

10.1101/2025.04.17.649327 — developmental biology — Posted on 2025-04-19

2084 Inverted Assembly of the Lens Within Ocular Organoids Reveals Alternate Paths to Ocular Morphogenesis

Stahl, E. F.; Delgado-Toscano, M. A.; Saravanan, I.; Paneva, A.; Wittbrodt, J.; Zilova, L.

10.1101/2025.04.17.649366 — developmental biology — Posted on 2025-04-19

2085 Feature-tuned synaptic inputs to somatostatin interneurons drive context-dependent processing

Hendricks, W. D.; Sadahiro, M.; Mossing, D. P.; Veit, J.; Adesnik, H.

10.1101/2025.04.16.649203 — neuroscience — Posted on 2025-04-19

2086 Glutamate delta-1 receptors regulate a novel tonic excitatory conductance in the mouse bed nucleus of the stria terminalis and influence neuronal function

Conley, S. Y.; Sizer, S. E.; Bedard, M. L.; McElligott, Z. A.

10.1101/2025.04.15.649028 — neuroscience — Posted on 2025-04-19

2087 Interpersonal Synchrony and Implicit Identification

Biswas, M.; Brass, M.

10.1101/2025.04.16.649093 — animal behavior and cognition — Posted on 2025-04-19

2088 Feature-temporal predictions dynamically modulate performance, feature-based attentional capture, and motor response activity during visual search

Williams, G. C.; Nobre, A. C.; Boettcher, S. E. P.

10.1101/2025.04.18.649503 — animal behavior and cognition — Posted on 2025-04-19

2089 Correspondence between sleep patterns and anhedonia in adult male mice exposed to early-life stress

Hall, A. G.; Burek, D. J.; Hisey, E. E.; Seabrook, L. T.; Fritsch, E. L.; Beatty, Z. G.; Ressler, K. J.; Kangas, B. D.; Carlezon, W. A.

10.1101/2025.04.18.649529 — animal behavior and cognition — Posted on 2025-04-19

2090 Social Context Restructures Behavioral Syntax in Mice

Ritter, M.; Shipley, H.; Deiana, S.; Hengerer, B.; Wotjak, C. T.; Brecht, M.; Bogadhi, A. R.

10.1101/2025.04.17.648924 — animal behavior and cognition — Posted on 2025-04-19

2091 Apical-basal polarity regulates Collagen IV-dependent cell-cell adhesion in the Drosophila adipose tissue

Franz, A.; Almasoud, J.; Andrieu, C.; Lee, B. H.

10.1101/2025.04.17.649307 — developmental biology — Posted on 2025-04-19

2092 Comprehensive comparative analysis of the effects of temperature on the Notch signaling response in vivo

John, N. S.; Tang, K. S.; Urman, M. A.; Lee, C.

10.1101/2025.04.18.649621 — developmental biology — Posted on 2025-04-19

2093 Identification of N-acetyl-rich heparan sulfate binding motifs and their role in expanding BMP distribution and signaling by Cerberus

Yamamoto, T.; Mii, Y.; Saiga, H.; Michiue, T.; Taira, M.

10.1101/2025.04.16.649141 — developmental biology — Posted on 2025-04-19

2094 Disruption of spindle orientation and protein localization during asymmetric cleavage by pharmacological inhibition of serotonin signaling

Nakamoto, A.; Nagy, L.

10.1101/2025.04.19.649612 — developmental biology — Posted on 2025-04-19

2095 Tnfrsf10 Signaling is Required to Maintain the Stem Cell Niche in the Zebrafish Lateral Line

Fan, C.; Yuan, X.; Wang, J.; Pei, W.; Zheng, H.; Zhang, X.; Burgess, S. M.

10.1101/2025.04.18.649014 — developmental biology — Posted on 2025-04-19

2096 Neural dynamics in superior colliculus of freely moving mice

Sharp, S. L.; Shin, J.; Martins, D. M.; Jones, K.; Niell, C. M.

10.1101/2025.04.16.648828 — neuroscience — Posted on 2025-04-19

2097 Algorithmic dissection of optic flow memory in larval zebrafish

Tanaka, R.; Portugues, R.

10.1101/2025.04.15.648832 — neuroscience — Posted on 2025-04-19

2098 Decoding the Unintelligible: Neural Speech Tracking in Low Signal-to-Noise Ratios

He, X.; Raghavan, V. S.; Mesgarani, N.

10.1101/2024.10.10.616521 — neuroscience — Posted on 2025-04-19

2099 Chemoenzymatic synthesis of sialylated and fucosylated mucin analogs reveals glycan-dependent effects on protein conformation and degradation.

Wood, A. M.; Wardzala, C. L.; Kramer, J. R.

10.1101/2025.04.15.648972 — bioengineering — Posted on 2025-04-19

2100 Diversification of large-effect loci in a duplicated genomic region leads to complex phenotypes

Barry, P. D.; Howe, N.; Owens, G. L.; Baetscher, D.; D'Amelio, K.; Vulstek, S.; Russell, J.; Lee, E.; Barclay, A.; Gharrett, A. J.; Tallmon, D. A.; Larson, W.

10.1101/2024.03.30.587279 — genomics — Posted on 2025-04-19

2101 The impact of common variants on gene expression in the human brain: from RNA to protein to schizophrenia risk

Liang, Q.; Jiang, Y.; Shieh, A. W.; Zhou, D.; Chen, R.; Wang, F.; Xu, M.; Niu, M.; Wang, X.; Pinto, D.; Wang, Y.; Cheng, L.; Vadukapuram, R.; Zhang, C.; Grennan, K.; Giase, G.; The PsychENCODE Consortium, ; White, K. P.; Peng, J.; Li, B.; Liu, C.; Chen, C.; Wang, S. H.

10.1101/2023.06.04.543603 — genetics — Posted on 2025-04-19

2102 Exploring the phylogenetic diversity and antimicrobial activity of non-aureus staphylococci and mammaliicocci isolated from teat apices of organic dairy cows

Pena-Mosca, F.; Gaire, T. N.; Dean, C. J.; Ferm, P.; Manriquez, D.; Pinedo, P.; Noyes, N.; Caixeta, L. S.

10.1101/2024.02.01.578391 — microbiology — Posted on 2025-04-19

2103 Closest relatives of poxviruses are spread in the gut of humans and animals worldwide: the egoviruses

Gaia, M.; Ruscheweyh, H.-J.; Eren, A. M.; Koonin, E. V.; Sunagawa, S.; Krupovic, M.; Delmont, T. O.

10.1101/2024.03.23.586382 — microbiology — Posted on 2025-04-19

2104 WMH-DualTasker: A weakly-supervised deep learning model for automated white matter hyperintensities segmentation and visual rating prediction

Wu, Y.; Dong, Z.; Li, H. B.; Chong, Y. F.; Ji, F.; Chong, J. S. X.; Tang, N. R. J.; Hilal, S.; Fu, H.; Chen, C. L.-H.; Zhou, J. H.

10.1101/2024.11.12.623137 — neuroscience — Posted on 2025-04-19

2105 Validating time-resolved fMRI with sub-second event durations

Wong, A. P. H.; Wu, E. X. W.; Rogers, B. P.; Asplund, C. L.

10.1101/2023.07.30.550770 — neuroscience — Posted on 2025-04-19

2106 Task structure tailors the geometry of neural representations in human lateral prefrontal cortex

Bhandari, A.; Keglovits, H.; Buyukyazgan, D.; Badre, D.

10.1101/2024.03.06.583429 — neuroscience — Posted on 2025-04-19

2107 A neural mechanism for compositional generalization of structure in humans

Luettgau, L.; Chen, N.; Erdmann, T.; Veselic, S.; Kurth-Nelson, Z.; Moran, R.; Dolan, R. J.

10.1101/2024.09.20.614119 — neuroscience — Posted on 2025-04-19

2108 Compositional selection of phospholipid compartments in icy environments drives the inheritance of encapsulated genetic information

Shinoda, T.; Noda, N.; Watanabe, T.; Kaneko, K.; Sekine, Y.; Matsuura, T.

10.1101/2025.04.16.648126 — synthetic biology — Posted on 2025-04-19

2109 Don't Benchmark Phenomic Prediction Against Genomic Prediction Accuracy

Wang, F.; Feldmann, M. J.; Runcie, D. E.

10.1101/2025.01.09.632209 — genetics — Posted on 2025-04-19

2110 Reinforcement of Fibrillar Collagen Hydrogels with Bioorthogonal Covalent Crosslinks

Brunel, L. G.; Long, C. M.; Christakopoulos, F.; Cai, B.; de Paiva Narciso, N.; Johansson, P. K.; Singhal, D.; Enejder, A.; Myung, D.; Heilshorn, S. C.

10.1101/2025.04.13.648560 — bioengineering — Posted on 2025-04-19

2111 OmniEM: Unifying the EM Multiverse through a Large-scale Foundation Model

He, L.; Shi, R.; Wang, W.; Ma, L.

10.1101/2025.04.13.648639 — bioengineering — Posted on 2025-04-19

2112 Optimizing Tissue Clearing Methods for Improved Imaging of Whole-Mount Retinas

Mutschler, A.; Malechka, V. V.; Baranov, P.; Soucy, J. R.

10.1101/2025.04.14.648787 — bioengineering — Posted on 2025-04-19

2113 Fluid forces control structural remodeling of blind-ended lymphatic microvessels

Holter, J. C.; Agarwal, S. S.; Tinapple, J. W.; Barlage, J. M.; Jones, T. H.; Song, J. W.

10.1101/2025.04.14.648799 — bioengineering — Posted on 2025-04-19

2114 PLGA Soya Lecithin Based Hybrid Nanocomposite for Targeted Topical Delivery of Resveratrol in Psoriasis Management

keshari, R.; Bagale, R.; Rath, S.; Raut, S.; Bhatt, L. K.; De, A.; Sen, S.; Srivastava, R.

10.1101/2025.04.13.648585 — bioengineering — Posted on 2025-04-19

2115 Resilience and restoration from fasting-refeeding mediated by a nutrient-regulated linker histone

Kawamura, K.; Diederich, A. R.; Gerisch, B.; Ripa, R.; Latza, C.; Steiner, J. D.; Fernandes, S.; Artoni, F.; Meyer, D. H.; Sant, D.; Oehm, S.; Grundmann, F.; Müller, R.-U.; Demetriades, C.; Antebi, A.

10.1101/2025.04.14.648802 — genetics — Posted on 2025-04-19

2116 Assessing plant phenological changes based on drivers of spring phenology

Jiang, Y.; Mayor, S.; Chu, X.; Ye, X.; Man, R.; Tao, J.; Dang, Q.-L.

10.1101/2025.04.13.648654 — ecology — Posted on 2025-04-19

2117 Stable coexistence and transport of lytic phage infections with migrating bacterial hosts

Marchi, J.; Khalek, C.; George, A.; Weitz, J. S.; Chait, R.

10.1101/2025.04.18.649568 — ecology — Posted on 2025-04-19

2118 Personalized Brain Morphometric Feature as a Transdiagnostic Predictor of Psychopathology: Insights from Dual Systems Models

Kang, M.; Song, K.-r.; Zhang, J.-l.; Xu, L.; Zhang, Y.; Zhao, Z.; Deng, H.; Fang, X.; Potenza, M. N.; Zhang, J.

10.1101/2025.04.14.644899 — developmental biology — Posted on 2025-04-19

2119 Expanding Targeted Instrumentation for Discovery Applications: Complement Reporter Ion Quantification with a Quadrupole-Ion Trap Instrument

Cruz, E. R.; Johnson, A. N.; Pujari, V.; Nguyen, T.; Stadlmeier, M.; Wang, J.; Jacob, C.; McAlister, G. C.; Remes, P. M.; Wühr, M.

10.1101/2025.04.18.649483 — systems biology — Posted on 2025-04-19

2120 NEMO recruitment at single cytokine-receptor complexes shows quantized dynamics independent of ligand affinity

Kim, A. H.; Krummenacher, B.; Yeung, J.; Koes, D. R.; Lee, R. E. C.

10.1101/2025.04.18.649561 — systems biology — Posted on 2025-04-19

2121 β-III tubulin identifies anti-fibrotic state of pericytes in pulmonary fibrosis

Sato, R.; Imamura, K.; Tsukui, T.; Yoshida, T.; Tomita, Y.; Fujino, K.; Ikeda, T.; Onizawa, K.; Sogo, T.; Combs, C. A.; Murgai, M.; Kopp, J. B.; Suzuki, M.; Sakagami, T.; Sheppard, D.; Mukouyama, Y.-s.

10.1101/2025.04.15.648984 — pathology — Posted on 2025-04-19

2122 Characterizing Clinical Toxicity in Cancer Combination Therapies

Wong, A. M.; Crawford, L.

10.1101/2025.04.13.648641 — bioinformatics — Posted on 2025-04-19

2123 JarrVis: Visualising Taxa-function relationships from meta-omic data

Desai, D. K.; Comeau, A. M.; Langille, M. G. I.

10.1101/2025.04.13.648596 — bioinformatics — Posted on 2025-04-19

2124 Enhanced delivery of lipid nanoparticle-based immunotherapy by modulating the tumor tissue stiffness using ultrasound-activated nanobubbles

Bhalotia, A.; Nittayacharn, P.; Mehta, M.; Iyer, A.; Hutchinson, D. W.; Cheplyansky, A.; Takizawa, K.; Nidhiry, A.; Gopalakrishnan, R.; Kosmides, T.; Exner, A. A.; Karathanasis, E.

10.1101/2025.04.13.648512 — bioengineering — Posted on 2025-04-19

2125 Biomechanics of orientationally ordered epithelial tissue

Vinals, J.; Angheluta, L.; Alford, P. W.

10.1101/2025.04.14.648846 — bioengineering — Posted on 2025-04-19

2126 Write and read: Harnessing Synthetic DNA Modifications for Nanopore Sequencing.

Bertocchi, U.; Grunwald, A.; Goldner, G.; Eitan, E.; Avraham, S.; Deek, J.; Michaeli, Y.; Yao, B.; Listgarten, J.; Simpson, J. T.; Timp, W.; Ebenstein, Y.

10.1101/2025.04.14.648727 — bioengineering — Posted on 2025-04-19

2127 Self-Organizing Neural Networks in Novel Moving Bodies: Anatomical, Behavioral, and Transcriptional Characterization of a Living Construct with a Nervous System

Fotowat, H.; O'Neill, L. E.; Pio-Lopez, L.; Sperry, M. M.; Erickson, P.; Lin, T.; Levin, M.

10.1101/2025.04.14.648732 — bioengineering — Posted on 2025-04-19

2128 Establishing Comprehensive Transthoracic Echocardiography Reference Ranges for Mouse Models: Insights into the Impact of Anesthesia, Sex, and Age

Oestereicher, M.; Ward, C.; Schneltzer, E.; Marschall, S.; Fuchs, H.; Gailus-Durner, V.; Bou About, G.; Selloum, M.; Meziane, H.; Stewart, M.; Teboul, L. E.; Norris, C.; Pimm, D.; Kan, M.; Lopez Gomez, F.; Wilson, R.; Monroy, M.; Pasha, S.; Zabrodska, E.; Prochazka, J.; Pajuelo Reguera, D.; Nichtova, Z.; Herault, Y.; Wells, S.; Parkinson, H.; Heaney, J.; Sedlacek, R.; Gao, X.; Hrabe de Angelis, M.; Spielmann, N.

10.1101/2025.04.14.647528 — genetics — Posted on 2025-04-19

2129 Predicting the patterns of kinship dynamics in human societies

He, P.; Dyble, M.; Johnstone, R. A.

10.1101/2025.04.13.648649 — evolutionary biology — Posted on 2025-04-19

2130 A comparison of turn identification methods on high-frequency movement trajectories reveals potential comparability issues between studies of movement ecology

Popp, S.; Codling, E. A.; Bailey, J. D.; Dornhaus, A.

10.1101/2025.04.13.647400 — ecology — Posted on 2025-04-19

2131 Biologically inspired warning patterns deter birds from wind turbines

Hancock, G. R. A.; Lehtonen, H.; Brown, T.; Ejjite, A.; Nokelainen, O.; Mappes, J.; Winters, S.

10.1101/2025.04.14.648692 — ecology — Posted on 2025-04-19

2132 Impacts of high pathogenicity avian influenza H5N1 2.3.4.4b south of the Antarctic Circle

Gorta, S. B. Z.; Neira, V.; Wille, M.; Gajardo, D.; Yılmaz, A.; Oktar, O.; Özsoy, B.; Sekercioglu, C. H.

10.1101/2025.04.13.648652 — ecology — Posted on 2025-04-19

2133 Dysregulated Proline Metabolism Contributes to Subretinal Fibrosis in Neovascular AMD: Therapeutic Potential of Prolyl-4-Hydroxylase Inhibition

Zeng, Y.; Zhang, T.; Cornish, E.; Lee, S.-R.; Yam, M.; Eminhizer, M.; Zeng, J.; Zhang, J.; Zeng, S.; Wei, X.; Yang, J.; Zhu, M.; Chang, A.; Zhang, M.; Du, J.; Zhu, L.; Gillies, M. C.

10.1101/2025.04.13.648057 — neuroscience — Posted on 2025-04-19

2134 Advancing Mobile Neuroscience: A Novel Wearable Backpack for Multi-Sensor Research in Urban Environments

Amaro, J.; Ramusga, R.; Bonifacio, A.; Frazao, J.; Almeida, A.; Lopes, G.; Chokhachian, A.; Santucci, D.; Morgado, P.; Miranda, B.

10.1101/2025.04.13.648607 — neuroscience — Posted on 2025-04-19

2135 Low-pH conditions drive transient changes in shell calcification and the microbiome in a pH-resistant strain of the the Pacific oyster Magallana gigas

Banker, R. M. W.; Stachowicz, J. J.; Gold, D.

10.1101/2025.04.13.648625 — systems biology — Posted on 2025-04-19

2136 Data driven shoe design improves running economy beyond state-of-the-art Advanced Footwear Technology running shoes

Kuzmeski, J. R.; Bertschy, M.; Healey, L.; Barrons, Z.; Hoogkamer, W.

10.1101/2025.04.13.648601 — physiology — Posted on 2025-04-19

2137 Dietary amino acid manipulations in the common marmoset Callithrix jacchus impacts serum metabolites and FGF21 levels

Fujita, Y.; Ishibuchi, T.; Uematsu, A.; Hayashi, T.; Obata, F.

10.1101/2025.04.14.648667 — physiology — Posted on 2025-04-19

2138 3D Focused Ion Beam Microscopy of Fossilized Albertosaurus sarcophagus reveals Nano to Microscale Structures

Williams, A.; Schumann, D.; Mallon, J. C.; Phaneuf, M. W.; Bassim, N.; Grandfield, K.

10.1101/2025.04.13.648590 — paleontology — Posted on 2025-04-19

2139 CytoAnalyst: A web-based platform for comprehensive single-cell RNA sequencing analysis

Bya, P.; Tran, D.; Nguyen, K.; Draghici, S.; Nguyen, T.

10.1101/2025.04.14.647594 — bioinformatics — Posted on 2025-04-19

2140 Generation of a Three-dimensional Human Neurovascular Unit Model in a Microfluidic Chip

Qiu, B.; Pompe, S.; Xenaki, K.; van Bergen en Henegouwen, P. M. P.; Oliveira, S.; Mastrobattista, E.; Caiazzo, M.

10.1101/2025.04.13.648605 — bioengineering — Posted on 2025-04-19

2141 Concordance of claudin-18.2 expression in biopsy, resection, and recurrent specimens: implications for zolbetuximab therapy in pancreatic ductal adenocarcinoma

Kyuno, D.; Yanazume, K.; Saito, A.; Ono, Y.; Ito, T.; Imamura, M.; Osanai, M.

10.1101/2025.04.11.648482 — pathology — Posted on 2025-04-19

2142 Plant domestication does not reduce diversity in root microbiomes

Hernandez-Teran, A.; Escalante, A. E.; Rebolleda-Gomez, M.

10.1101/2025.01.13.632861 — ecology — Posted on 2025-04-19

2143 Bacteriophage-host interactions in microgravity aboard the International Space Station

Huss, P.; Chitboonthavisuk, C.; Meger, A.; Nishikawa, K.; Oates, R. P.; Mills, H.; Holzhaus, O.; Raman, S.

10.1101/2023.10.10.561409 — synthetic biology — Posted on 2025-04-19

2144 Base Editing Rescue of Seizures and SUDEP in SCN8A Developmental Epileptic Encephalopathy

Reever, C. M.; Boscia, A. R.; Deutsch, T. C. J.; Patel, M. P.; Miralles, R. M.; Kittur, S.; Fleischel, E. J.; Buo, A. M. L.; Yorek, M. S.; Meisler, M. H.; Farber, C. R.; Patel, M. K.

10.1101/2025.04.09.647983 — bioengineering — Posted on 2025-04-19

2145 Obesity promotes urinary tract infection by disrupting urothelial immune defenses

Schwartz, L.; Salamon, K.; Simoni, A.; Cotzomi-Ortega, I.; Sanchez-Zomora, Y.; Linn-Peirano, S.; John, P.; Ruiz-Rosado, J. d. D.; Jackson, A. R.; Wang, X.; Spencer, J. D.

10.1101/2025.04.04.647270 — cell biology — Posted on 2025-04-19

2146 singIST: an integrative method for comparative single-cell trancriptomics between disease models and humans

Moruno-Cuenca, A.; Picart-Armada, S.; Perera-Lluna, A.; Fernandez-Albert, F.

10.1101/2024.12.20.629624 — bioinformatics — Posted on 2025-04-19

2147 Impaired hippocampal circuit function underlying memory encoding and consolidation precede robust Aβ deposition in a mouse model of Alzheimer's disease

Li, H.; Zhao, Z.; Fassini, A.; Lee, H. K.; Green, R. J.; Gomperts, S. N.

10.1101/2024.05.26.595168 — neuroscience — Posted on 2025-04-19

2148 Shapley Fields Reveal Chemotopic Organization in the Mouse Olfactory Bulb Across Diverse Chemical Feature Sets

Milicevic, N.; Itskov, V.; Wachowiak, M.; Burton, S. D.

10.1101/2025.02.26.640432 — neuroscience — Posted on 2025-04-19

2149 Revival of traditional agricultural systems A multidisciplinary on-farm survey of maize-bean intercropping reveals unexpected competition effects on beans.

Vazeux-Blumental, N.; Mathieu, L.; Trabac, T.; Palaffre, C.; Lagardere, B.; Carraretto, M.; Bauland, C.; Le Guilloux, M.; Paysant-Le Roux, C.; Caius, J.; Marmagne, A.; Enjalbert, J.; Flutre, T.; Le Cadre, E.; Parnaudeau, V.; Muller, D.; Moenne-Loccoz, Y.; Manicacci, D.; Tenaillon, M. I.

10.1101/2024.04.24.590929 — plant biology — Posted on 2025-04-19

2150 Easydecon: A Lightweight Workflow for Cell Type Analysis in High-Definition Spatial Transcriptomics Assays

Umu, S. U.; Karlsen, V. T.; Baekkevold, E. S.; Jahnsen, F. L.; Domanska, D.

10.1101/2025.04.08.647764 — bioinformatics — Posted on 2025-04-19

2151 Mosquito sex under lock and key

Houri-Zeevi, L.; Walker, M. M.; Razzauti, J.; Sharma, A.; Pasolli, H. A.; Vosshall, L. B.

10.1101/2025.04.11.648401 — animal behavior and cognition — Posted on 2025-04-19

2152 Systematic modulation of sensorimotor learning by domain-specific working memory

O'Bryan, S. R.; Liddy, J. J.; Song, J.-H.

10.1101/2025.04.11.648414 — neuroscience — Posted on 2025-04-19

2153 Neural basis of concurrent deliberation toward a choice and confidence judgement

Vivar-Lazo, M.; Fetsch, C. R.

10.1101/2024.08.06.606833 — neuroscience — Posted on 2025-04-19

2154 Inhibitory basal ganglia nuclei differentially innervate pedunculopontine nucleus subpopulations and evoke opposite motor and valence behaviors.

Fallah, M.; Udobi, K. C.; Swiatek, A. E.; Scott, C. B.; Evans, R. C.

10.1101/2024.08.05.606694 — neuroscience — Posted on 2025-04-19

2155 Neural Gain Modulation Propagates from Posterior to Anterior Brain Regions to Optimize Orientation Perception in Chronic Astigmatism

Son, S.; Kang, H.; Kim, H. R.; Shim, W. M.; Lee, J.

10.1101/2025.04.13.648557 — neuroscience — Posted on 2025-04-19

2156 Bipartite invariance in mouse primary visual cortex

Ding, Z.; Tran, D. T.; Ponder, K.; Ding, Z.; Froebe, R.; Ntanavara, L.; Fahey, P. G.; Cobos, E.; Baroni, L.; Diamantaki, M.; Wang, E.; Chang, A.; Papadopoulos, S.; Fu, J.; Muhammad, T.; Papadopoulos, C.; Cadena, S. A.; Evangelou, A.; Willeke, K.; Anselmi, F.; Sanborn, S.; Antolik, J.; Froudarakis, E.; Patel, S.; Walker, E. Y.; Reimer, J.; Sinz, F. H.; Ecker, A. S.; Franke, K.; Pitkow, X.; Tolias, A. S.

10.1101/2023.03.15.532836 — neuroscience — Posted on 2025-04-19

2157 Experimental suppression of a keystone protist triggers mesopredator release and biotic homogenization in complex soil microbial communities

Maillard, F.; Klinghammer, F.; Beatty, B.; Zou, H.; Lara, E.; Hammer, E. C.; Tunlid, A.; Kennedy, P.

10.1101/2025.04.13.648592 — ecology — Posted on 2025-04-18

2158 Developmental, neuroanatomical and cellular expression of genes causing dystonia

Cameron, D.; Clifton, N. E.; de la Fuente, D. C.; Holmans, P.; Bray, N. J.; Peall, K.

10.1101/2025.04.13.648593 — neuroscience — Posted on 2025-04-18

2159 Single-cell atlas of patient-derived cervical organoids uncovers epithelial immune heterogeneity and intercellular crosstalk during Chlamydia infection

Prakash, P. G.; Kumar, N.; Koster, S.; Wentland, C.; Dhanraj, J.; Gurumurthy, R. K.; Chumduri, C.

10.1101/2025.04.13.648603 — systems biology — Posted on 2025-04-18

2160 Warning signals for long-term innovative potential of genetic research under commercial pressure

Chae, J.; Kim, W.; Jung, W.; Jeong, D.; Lim, R.; Chamlagain, M.; Jung, G.; Jang, J.; Lee, J. W.; Kang, N. K.; Baek, K.; Shin, J.; Lee, Y.-G.; Koh, H. G.; Kim, C.; Yook, S.; Cheung, A. K. L.; Jin, Y.-S.; Youn, H.; Kim, P.-J.; Ghim, C.-M.

10.1101/2025.02.17.638429 — scientific communication and education — Posted on 2025-04-18

2161 Altair-LSFM: A High-Resolution, Easy-to-Build Light-Sheet Microscope for Sub-Cellular Imaging

Haug, J.; Gałecki, S.; Dean, K. M.

10.1101/2025.04.08.647739 — biophysics — Posted on 2025-04-18

2162 SIEVE: One-stop differential expression, variability, and skewness analyses using RNA-Seq data

Li, H.; Khang, T. F.

10.1101/2024.04.09.588804 — bioinformatics — Posted on 2025-04-18

2163 MPBind: Multitask Protein Binding Site Prediction by Protein Language Models and Equivariant Graph Neural Networks

wang, y.; Boadu, F.; Cheng, J.

10.1101/2025.04.12.648527 — bioinformatics — Posted on 2025-04-18

2164 DTMol: Pocket-based Molecular Docking using Diffusion Transformers

Teng, H.; Wang, R.; Shen, Y.; Yuan, Y.; Kingsford, C.

10.1101/2025.04.13.648103 — bioinformatics — Posted on 2025-04-18

2165 Genomic and Behavioral Signatures of Selection for Ethanol Preference from the Heterogeneous Stock Collaborative Cross Mice: The Central Nucleus of the Amygdala

Anderson, J. Q.; Darakjian, P.; Hitzemann, R. J.; Cervera-Juanes, R.; Zimmerman, K. D.; Reed, C.; Ozburn, A. R.; Lockwood, D.; Phillips, T. J.

10.1101/2025.04.15.649004 — genomics — Posted on 2025-04-18

2166 Development and validation of KASP markers for a novel powdery mildew resistance gene in wheat using BSR-Seq analysis

Kaur, R.; Tyagi, V.; Dhariwal, R.; Sheikh, I.; Dhaliwal, H. S.; Sivasamy, M.; Sivakumar, T.; Kumar, S.; Ravat, V. K.; Vasistha, N. K.

10.1101/2025.04.12.648525 — genetics — Posted on 2025-04-18

2167 How to quantify immigration from community abundance data using the Neutral Community Model

Rafay, R.; Jones, E. W.; Sivak, D.; Fowler, J.

10.1101/2025.04.12.648546 — ecology — Posted on 2025-04-18

2168 Sustained Antigen Stimulation to Evoke and Study Negative feedback Systems responsible for Self-Tolerance /Tumor Immune Escape and transition to the M2 macrophage

Mazzio, E.; Barnes, A.; Badisa, R.; Darling-Reed, S.; Soliman, K. F.

10.1101/2025.04.13.648563 — immunology — Posted on 2025-04-18

2169 Alpha-synuclein aggregation and dopaminergic neuron death in a new mouse model of Parkinson disease expressing human full-length and C-terminally truncated 1-120 alpha-synuclein.

Longhena, F.; Zheng, Z.; Faustini, G.; Wegrzynowicz, M.; Carlson, E.; Casadei, N.; Riess, O.; Bellucci, A.; Spillantini, M. G.

10.1101/2025.04.13.647581 — neuroscience — Posted on 2025-04-18

2170 Sustained visual signals in the primate cerebellar dentate nucleus drive associative learning

Akiyama, Y.; Yamada, H.; Matsumoto, M.; Kunimatsu, J.

10.1101/2025.04.13.648306 — physiology — Posted on 2025-04-18

2171 Slow Gompertzian aging in long-lived C. elegans results from expansion of decrepitude, not decelerated aging

Zhang, B.; Gems, D.

10.1101/2025.04.13.648378 — physiology — Posted on 2025-04-18

2172 New Δ246p53 isoform responds to DNA damage to enhance p53 functions in senescence and tumour suppression

Parkar, S. N.; Ramalho, A. C.; Lopez-Iniesta, M. J.; Kimura, K.; Zhao, J.; da Silva Rita, F.; Romao, L.; Candeias, M. M.

10.1101/2023.04.07.536059 — cancer biology — Posted on 2025-04-18

2173 AMOEBA Polarizable Molecular Dynamics Simulations of Guanine Quadruplexes: from the c-Kit Proto-oncogene to HIV-1

El Ahdab, D. S.; Lagardere, L.; Hobaika, Z.; Jaffrelot Inizan, T.; Celerse, F.; Gresh, N.; Maroun, R. G.; Piquemal, J.-P.

10.1101/2024.08.28.610081 — biophysics — Posted on 2025-04-18

2174 Stress anisotropy in 3D active curved structures

Lou, Y.; Theis, S.; Rupprecht, J. F.; Saunders, T. E.; Hiraiwa, T.

10.1101/2025.04.13.648577 — biophysics — Posted on 2025-04-18

2175 CASSIA: a multi-agent large language model for reference free, interpretable, and automated cell annotation of single-cell RNA-sequencing data

Xie, E.; Cheng, L.; Shireman, J.; Cai, Y.; Liu, J.; Mohanty, C.; Dey, M.; Kendziorski, C.

10.1101/2024.12.04.626476 — bioinformatics — Posted on 2025-04-18

2176 CellSP: Module discovery and visualization for subcellular spatial transcriptomics data

Aggarwal, B.; Sinha, S.

10.1101/2025.01.12.632553 — bioinformatics — Posted on 2025-04-18

2177 One-click image reconstruction in single-molecule localization microscopy via deep learning

Saguy, A.; Xiao, D.; Narayanasamy, K. K.; Nakatani, Y.; Gustavsson, A.-K.; Heilemann, M.; Shechtman, Y.

10.1101/2025.04.13.648574 — bioengineering — Posted on 2025-04-18

2178 PyFuRNAce: An integrated design engine for RNA origami

Monari, L.; Braun, I.; Poppleton, E.; Göpfrich, K.

10.1101/2025.04.17.647389 — bioengineering — Posted on 2025-04-18

2179 High-Throughput Synthesis and Screening of a Cyanimide Library Identifies Selective Inhibitors of ISG15-specific Protease USP18

Kooij, R.; Pol, V.; Gan, J.; van Doodewaerd, B.; Sapmaz, A.; Fritz, G.; Knobeloch, K.-P.; Geurink, P. P.

10.1101/2025.04.18.649523 — biochemistry — Posted on 2025-04-18

2180 Local Genetic Sex Differences in Quantitative Traits

Uffelmann, E.; de Leeuw, C.; Schipper, M.; Posthuma, D.

10.1101/2023.05.04.539410 — genetics — Posted on 2025-04-18

2181 STRIPAK complex defects result in pseudosexual reproduction in Cryptococcus neoformans

Peterson, P. P.; Croog, S.; Choi, Y.; Sun, S.; Heitman, J.

10.1101/2025.04.08.647827 — genetics — Posted on 2025-04-18

2182 The role of m6A RNA methylation in the maintenance of X-chromosome inactivation and X to autosome dosage compensation in early embryonic lineages

Naik, H. C.; Baro, R.; Sarkar, A.; M, M. N.; Sunagar, K.; GAYEN, S.

10.1101/2024.04.22.590572 — genetics — Posted on 2025-04-18

2183 Translation Accuracy in E. coli

Stikeleather, R.; Ali, F.; Ho, W.-C.; Licknack, T.; Lynch, M.

10.1101/2025.04.18.649569 — evolutionary biology — Posted on 2025-04-18

2184 Warming increases richness and shapes assemblages of eukaryotic parasitic plankton

Rajarajan, A.; Cerbin, S.; Beng, K. C.; Monaghan, M. T.; Wolinska, J.

10.1101/2024.12.31.630883 — ecology — Posted on 2025-04-18

2185 Modeling control of invasive fire ants by gene drive

Liu, Y.; Champer, S. E.; Haller, B. C.; Champer, J.

10.1101/2025.03.04.641467 — ecology — Posted on 2025-04-18

2186 Recombination alters the furin cleavage site in novel bat-borne HKU5-CoV-2 coronavirus

Yeh, T.-Y.; Tsai, V.; Liao, S. M.; Hong, C.-E.; Kuo, F.-Y.; Wang, Y. C.; Feehley, M. C.; Feehley, P. J.; Lai, Y.-C.; Contreras, G. P.

10.1101/2025.04.17.649446 — microbiology — Posted on 2025-04-18

2187 Cooperation Between Genotoxic Bacteria Accelerates Tumorigenesis in a Mouse Model of Colon Carcinogenesis

Plitt, T.; Piessevaux, A.; Rajpal, U.; Fisher, J.; Spindler, M. P.; Li, Z.; Mogno, I.; Yang, Y.; Desch, A. N.; Chu, G.; Jiang, Z.; Wang, J.; Gevers, D.; Pocalyko, D.; Geis, A. L.; Jobin, C.; Bachman, K. E.; Sears, C. L.; Britton, G. J.; San Mateo, L. R.; Faith, J.

10.1101/2025.04.18.649375 — microbiology — Posted on 2025-04-18

2188 Moisture Controls on Hydrogen Oxidizing Bacteria: Implications for the Global Soil Hydrogen Sink

Reji, L.; Bertagni, M.; Paulot, F.; Qin, Q.; Zhang, X.

10.1101/2025.04.18.649571 — microbiology — Posted on 2025-04-18

2189 Frontal oscillatory beta bursts have rhythmically distinct regimes with differing functional relevance

Langford, Z. D.; Procyk, E.; Wilson, C. R.

10.1101/2023.11.13.566594 — neuroscience — Posted on 2025-04-18

2190 Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues

Glaser, A.; Chandrashekar, J.; Vasquez, S.; Arshadi, C.; Javeri, R.; Ouellette, N.; Jiang, X.; Baka, J.; Kovacs, G.; Woodard, M.; Seshamani, S.; Cao, K.; Clack, N.; Recknagel, A.; Grim, A.; Balaram, P.; Turschak, E.; Hooper, M.; Liddell, A.; Rohde, J.; Hellevik, A.; Takasaki, K.; Erion Barner, L.; Logsdon, M.; Chronopoulos, C.; de Vries, S.; Ting, J.; Perlmutter, S.; Kalmbach, B.; Dembrow, N.; Tasic, B.; Reid, R. C.; Feng, D.; Svoboda, K.

10.1101/2023.06.08.544277 — neuroscience — Posted on 2025-04-18

2191 Neural and Behavioral Changes in Older Adults from Auditory-Cognitive Training

Fisher, C.; Karunathilake, I. M. D.; Johns, M. A.; Vance, A.; Kuchinsky, S. E.; Anderson, S.; Simon, J. Z.

10.1101/2025.04.01.646593 — neuroscience — Posted on 2025-04-18

2192 Rankings of tuberculosis antibiotic treatment regimens are sensitive to spatial scale, detection limit, and initial host bacterial burden

Michael, C. T.; Budak, M.; Maiello, P.; Kracinovsky, K.; Rodgers, M.; Tomko, J.; Lin, P. L.; Flynn, J. L.; Linderman, J. J.; Kirschner, D.

10.1101/2025.04.10.648004 — systems biology — Posted on 2025-04-18

2193 Global Skeletal Muscle Metabolomics Reveals Mechanisms Behind Higher Response to Resistance Training in Older Adults

Lim, C.; Lixandrao, M.; Trivedi, D.; Xu, Y.; Prokopidis, K.; Roschel, H.; Phillips, S. M.; Muhamadali, H.; Isanejad, M.

10.1101/2025.03.13.642876 — systems biology — Posted on 2025-04-18

2194 Design and optimization of a kinase-controlled allosteric switch

Cao, Q.; Toettcher, J. E.

10.1101/2025.04.15.648940 — synthetic biology — Posted on 2025-04-18

2195 Metabolite profiling reveals slow and uncoordinated adjustment of C4 photosynthesis to sudden changes in irradiance

Arrivault, S.; Medeiros, D. B.; Sales, C. R. G.; Guenther, M.; Kromdijk, J.; Fernie, A. R.; Stitt, M.

10.1101/2025.04.13.648559 — plant biology — Posted on 2025-04-18

2196 Optimisation of explant-specific isolation, culture, and micro-callus induction of sesame (Sesamum indicum L.) protoplasts

Debnath, A. J.; Sikdar, S. R.; Basu, D.

10.1101/2024.10.12.618049 — plant biology — Posted on 2025-04-18

2197 Functional relevance of CASP16 nucleic acid predictions as evaluated by structure providers

Kretsch, R. C.; Albrecht, R.; Andersen, E. S.; Chen, H.-A.; Chiu, W.; Das, R.; Gezelle, J. G.; Hartmann, M. D.; Hobartner, C.; Hu, Y.; Jadhav, S.; Johnson, P. E.; Jones, C. P.; Koirala, D.; Kristoffersen, E. L.; Largy, E.; Lewicka, A.; Mackereth, C. D.; Marcia, M.; Nigro, M.; Ojha, M.; Piccirilli, J. A.; Rice, P. A.; Shin, H.; Steckelberg, A.-L.; Su, Z.; Srivastava, Y.; Wang, L.; Wu, Y.; Xie, J.; Zwergius, N. H.; Moult, J.; Kryshtafovych, A.

10.1101/2025.04.15.649049 — biophysics — Posted on 2025-04-18

2198 A novel decoding strategy for ProteinMPNN to design with less MHC Class I immune-visibility

Gasser, H.-C.; Rajan, A.; Alfaro, J. A.

10.1101/2025.04.14.648837 — bioinformatics — Posted on 2025-04-18

2199 StACKER, A TOOL FOR SYSTEMS LEVEL ANALYSIS OF BASE STACKING IN NUCLEOTIDE-RICH STRUCTURES

Sakkas, E. D.; Krizanc, D.; Thayer, K. M.; Weir, M. P.

10.1101/2025.04.13.648419 — bioinformatics — Posted on 2025-04-18

2200 Polymorphic α-Glucans as Structural Scaffolds in Cryptococcus Cell Walls for Chitin, Capsule, and Melanin: Insights from 13C and 1H Solid-State NMR

Ankur, A.; Yarava, J. R.; Gautam, I.; Scott, F.; Mentink-Vigier, F.; Chrissian, C.; Xie, L.; Roy, D.; Stark, R. E.; Doering, T.; Wang, P.; Wang, T.

10.1101/2025.04.18.649559 — biochemistry — Posted on 2025-04-18

2201 Cryo-EM structure revealed a novel F-actin binding motif in a Legionella pneumophila lysine fatty-acyltransferase

Zeng, W. W.; Komaniecki, G.; Liu, J.; Lin, H.; Mao, Y.

10.1101/2025.04.18.649563 — biochemistry — Posted on 2025-04-18

2202 Mammary gland metabolism and its relevance to the fetoplacental expression of cytokine signaling in Caveolin-1 null mice

Poudel, S. P.; Islam, M.; McFadden, T. B.; Behura, S. K.

10.1101/2025.04.13.648647 — genomics — Posted on 2025-04-18

2203 Application of a French cattle pangenome, from structural variant discovery to association studies on key phenotypes

Sorin, V.; Naji, M.-M.; Birbes, C.; Grohs, C.; Escouflaire, C.; Fritz, S.; Eche, C.; Marcuzzo, C.; Suin, A.; Donnadieu, C.; Gaspin, C.; Iampietro, C.; Milan, D.; Drouilhet, L.; Tosser-Klopp, G.; Boichard, D.; Klopp, C.; Sanchez, M.-P.; Boussaha, M.

10.1101/2025.04.15.648672 — genetics — Posted on 2025-04-18

2204 Transcriptomic bases of within- and trans-generational predator-induced plasticity in the freshwater snail Physa acuta

Dejeux, L.; Saclier, N.; Tariel-Adam, J.; Hoareau, M.; Lefebure, T.; Konecny, L.; Plenet, S.; Luquet, E.

10.1101/2024.10.16.618730 — evolutionary biology — Posted on 2025-04-18

2205 Single cell multi-omic whole genome sequencing and chromatin accessibility profiling reveals genome-epigenome coevolution in colorectal cancer

Mossner, M.; Colson, C.; Guo, Q.; Whiting, F.; Grant, H.; Stafford, A.; Kyle, P.; Donato-Brown, D.; Murphy, J.; Sottoriva, A.; Baker, A.-M.; Graham, T.

10.1101/2025.04.15.648959 — molecular biology — Posted on 2025-04-18

2206 Structural basis for UDG identifying DNA damage in the nucleosome

Ghediri, S.; Blossey, R.; Cleri, F.

10.1101/2025.04.17.649289 — molecular biology — Posted on 2025-04-18

2207 Identification of determinants of high-fidelity DNA synthesis in M. smegmatis DnaE1 through in silico and in vivo approaches

Kuin, R.; van Westen, G. J. P.; Lamers, M. H.

10.1101/2025.04.17.649371 — molecular biology — Posted on 2025-04-18

2208 Fast, Flexible, Feasible: A Transparent Framework for Evaluating eDNA Workflow Trade-offs in Resource-Limited Settings

Ip, Y. C. A.; Allan, E. A.; Hirsch, S. L.; Kelly, R. P.

10.1101/2025.04.16.649249 — molecular biology — Posted on 2025-04-18

2209 In vivo efficacy of fidaxomicin against rpoB mutant Clostridioides difficile infection.

Mai Thu, H.; Hitomi, Y.; Fujii, T.; Morinaga, Y.

10.1101/2025.04.17.649461 — microbiology — Posted on 2025-04-18

2210 Evolution of T cell responses in the tuberculin skin test reveals generalisable Mtb-reactive T cell metaclones.

Turner, C. T.; Tiffeau-Mayer, A.; Rosenheim, J.; Chandran, A.; Saxena, R.; Zhang, P.; Jiang, J.; Berkeley, M.; Pang, F.; Uddin, I.; Nageswaran, G.; Byrne, S.; Karthikeyan, A.; Smidt, W.; Ogongo, P.; Byng-Maddick, R.; Capocci, S.; Lipman, M.; Kunst, H.; Lozewicz, S.; Rasmussen, V.; Pollara, G.; Knight, J. C.; Leslie, A.; Chain, B. M.; Noursadeghi, M.

10.1101/2025.04.12.648537 — immunology — Posted on 2025-04-18

2211 First vs recurrent episode symptomatology in Major Depressive Disorder and its relation to brain function and structure: a network approach.

Angeles Valdez, D.; van Tol, M.-J.; Garza-Villarreal, E. A.

10.1101/2025.04.12.648523 — neuroscience — Posted on 2025-04-18

2212 N1 cassette-lacking NMDA receptors mediate the antidepressant activity of ketamine

He, A. T.; Zhang, W.; Li, H.; Tu, Y.; Lee, D.; Kim, D.; Jia, Z.; Wang, L.-Y.; SALTER, M. W.

10.1101/2025.04.12.648536 — neuroscience — Posted on 2025-04-18

2213 Statistical Molecular Interaction Fields: A Fast andInformative Tool for Characterizing RNA and ProteinBinding Pockets

Barquero Morera, D.; Mattiotti, G.; Kocev, A.; Rousselot, A.; Rouaud, L.; santuz, H.; Baaden, M.; Taly, A.; Pasquali, S.

10.1101/2025.04.16.649117 — biophysics — Posted on 2025-04-18

2214 SM3DD with Segmented PCA: A Comprehensive Method for Interpreting 3D Spatial Transcriptomics

Blick, T.; Kilgallon, A.; Monkman, J.; Cooper, C.; Tan, C. W.; Killingbeck, E.; Pan, L.; Kim, Y.; Liang, Y.; Nam, A.; Leon, M.; Souza-Fonseca-Guimaraes, P.; Seigo Nagashima, S.; Martins, A. P. C.; Machado-Souza, C.; De Noronha, L.; Fraser, J. F.; Belz, G.; Souza-Fonseca-Guimaraes, F.; Kulasinghe, A.

10.1101/2025.04.17.649456 — bioinformatics — Posted on 2025-04-18

2215 Assessing the relation between protein phosphorylation, AlphaFold3 models and conformational variability

Ramasamy, P.; Zuallaert, J.; Martens, L.; Vranken, W. F.

10.1101/2025.04.14.648669 — bioinformatics — Posted on 2025-04-18

2216 Uncovering Shared and Tissue-Specific Molecular Adaptations to Intermittent Fasting in Liver, Brain, and Muscle

Fan, Y.; De Silva, S.; Tabassum, N. I.; Peng, X.; Lim, V.; Cheng, X.; Datta, K. K.; Lowe, R.; Johns, T. G.; Mattson, M. P.; Mathivanan, S.; Sobey, C. G.; Okun, E.; Liu, Y. U.; Chen, G.; Lai, M. K. P.; Jo, D.-G.; Gunaratne, J.; Arumugam, T. V.

10.1101/2025.04.13.648650 — molecular biology — Posted on 2025-04-18

2217 Sustained cross-species transmission of gammacoronavirus in wild birds reveled by viral characterization in China

Wang, D.-S.; Zou, Y.-Y.; Liu, Q.; Huang, H.; Han, P.-Y.; Zhao, J.-Y.; Zong, L.-D.; Qiu, Y.; Zhang, Y.-Z.; Ge, X.-Y.

10.1101/2025.04.17.648926 — microbiology — Posted on 2025-04-18

2218 Towards the Development of an Algae-Bacteria Pest Model: Enrichment of Oligoflexales Bacteria in Nannochloropsis oceanica Cultures with Different Starting Microbiomes

Nguyen, T. M.; Abeykoon, W. K. N. L.; Corcoran, A. A.

10.1101/2025.04.17.649447 — microbiology — Posted on 2025-04-18

2219 Association of OXA-1 and TEM-1 Genes with Antibiotic Resistance to Piperacillin/Tazobactam in ESBL-Producing Pathogens: Insights from a Multi-Center Analysis

Kamau, E.; Wong, B.; MacArthur, J.; Dombach, J. L.

10.1101/2025.04.18.649505 — microbiology — Posted on 2025-04-18

2220 Chemical Probe Discovery for DEAD-box RNA Binding Protein DDX21 using Small Molecule Microarrays

Calo, E.; Koehler, A. N.; Aiba, T.

10.1101/2025.04.18.649545 — cancer biology — Posted on 2025-04-18

2221 High-Dimensional Protein Analysis Uncovers Distinct Immunological and Stromal Signatures Between Primary and Metastatic Pancreatic Ductal Adenocarcinoma

Greene, E.; Horvat, N. K.; Doxie, D. B.; Parihar, V. C.; Kim, J.; Herting, C. J.; Grundy, E. E.; Ruffin, A. T.; Krasinskas, A. M.; Maithel, S. K.; Sarmiento, J. M.; Shah, M. M.; Zaidi, M. Y.; Diab, M.; Alese, O. B.; Dhodapkar, K.; Kissick, H. T.; El-Rayes, B. F.; Paulos, C. M.; Lesinski, G. B.

10.1101/2025.04.18.649381 — cancer biology — Posted on 2025-04-18

2222 Phospholipid Scramblases TMEM16F and Xkr8 regulate distinct features of Phosphatidylserine (PS) externalization and immune regulation in the tumor microenvironment to regulate tumor growth

Birge, R. B.; Gadiyar, V.; Pulica, R.; Aquib, A.; Tranos, J. A.; Varsanyi, C.; Almansa, L. F.; Gaspers, L.; De Lorenzo, M.; Kotenko, S. V.; Tripathi, S.; Howell, R. W.; Choudhary, A.; Calianese, D. C.

10.1101/2025.04.17.649445 — cancer biology — Posted on 2025-04-18

2223 Transcriptomic profiling of a novel gastric implantation model identifies mechanisms and pathways that drive implantation into explanted human peritoneum

Ng, D.; Kazazian, K.; Lee, K.; Lu, Y. Q.; Ali, A.; Pacholczyk, K.; Brar, S.; Conner, J.; Jurisica, I.; McCulloch, C. A.; Kim, D.-K.; Swallow, C. J.; Magalhaes, M.

10.1101/2025.04.14.648628 — cancer biology — Posted on 2025-04-18

2224 Prediction of Outcome from Spatial Protein Profiling of Triple-Negative Breast Cancers

Foroughi pour, A.; Wu, T.-c.; Martinek, J.; Sivajothi, S.; Robson, P.; Palucka, K.; Chuang, J. H.

10.1101/2025.04.18.649541 — cancer biology — Posted on 2025-04-18

2225 Inhibition Of One-Carbon Metabolism In Ewing Sarcoma Results In Profound And Prolonged Growth Suppression Associated With Purine Depletion

Zirpoli, S.; Copperman, N.; Patel, S.; Forrest, A.; Hou, Z.; Matherly, L. H.; Loeb, D. M.; Di Cristofano, A.

10.1101/2025.04.13.647987 — cancer biology — Posted on 2025-04-18

2226 KRAS Inhibition Reverses Chemotherapy Resistance Promoted by Therapy-Induced Senescence-like in Pancreatic Ductal Adenocarcinoma

Meilerman Abuelafia, A.; Santofimia-Castano, P.; Estaras, M.; Grasso, D.; Chuluyan, E.; Lomberk, G.; Urrutia, R.; Dusetti, N.; Fraunhoffer, N.; Iovanna, J.

10.1101/2025.04.13.648164 — cancer biology — Posted on 2025-04-18

2227 Matrix stiffness-induced IKBKE and MAPK8 signaling drives a phenotypic switch from DCIS to invasive breast cancer

Yan, F.; Goransson, S. A.; Olofsson, H.; Vogiatzakis, C.; Acharekar, A.; Stromblad, S.

10.1101/2025.04.16.649065 — cancer biology — Posted on 2025-04-18

2228 The Role of Phenotypic Plasticity in Adaptation to Treatment and Prospective Plasticity Drivers in Hepatoblastoma

Chen, E.; English, C.; Allo Anido, A.; Hamer, S.; Cairo, S.; Bruna, A.

10.1101/2025.04.16.648783 — cancer biology — Posted on 2025-04-18

2229 Analysis of Divergent Gene Expression between HPV+ and HPV- Head and Neck Squamous Cell Carcinoma Patients

Shankar, K.; Walker, S. E.

10.1101/2025.04.14.648798 — cancer biology — Posted on 2025-04-18

2230 A small molecule inhibitor of RNA-binding protein IGF2BP3 shows anti-leukemic activity

Rao, D. S.; Jaiswal, A. K.; Scherer, G. M.; Thaxton, M.; Sorrentino, J.; Yuen, C.; Mehta, M.; SHARMA, G.; Lin, T. L.; Tran, T.; Cohen, A.; Ritters, A. J.; Kotecha, R.; Sanford, J.; Damoiseaux, R.; Garg, N.

10.1101/2025.04.14.648780 — cancer biology — Posted on 2025-04-18

2231 Identification of novel therapeutic inhibitors against E6 and E7 oncogenes of HPV-16 associated with cervical cancer

Younas, S.; Malik, Z. I.; Khan, M. U.; Manzoor, S.; Hammad, H. M.; Rehman, H. M.; Akter, S.

10.1101/2025.04.13.648624 — cancer biology — Posted on 2025-04-18

2232 MYBL2 maintains stemness and promotes theta-mediated end joining in triple negative breast cancer

Bayley, R.; Munsey, A.; Ahmed, S.; Ward, C.; Stiby, A.; Briantseva, B.-M.; Jawanda, K.; Shaaban, A. M.; Saponaro, M.; Smith, G. C. M.; Clarke, R. B.; Davies, C.; Garcia, P.

10.1101/2025.04.15.648875 — cancer biology — Posted on 2025-04-18

2233 Small Extracellular Vesicles from Radioresistant H3K27M-Pediatric Diffuse Midline Glioma Cells Modulate Tumor Phenotypes and Radiation Response

Oza, V. D.; Flores, K. A.; Chernyavskaya, Y.; Al Hamaly, M. A.; Smith, C. B.; Bruntz, R. C.; Blackburn, J. S.

10.1101/2025.04.14.648723 — cancer biology — Posted on 2025-04-18

2234 Immune Niche Formation in Engineered Mouse Models Reveals Mechanisms of Tumor Dormancy

Ahad, A.; Leng, F.; Ichise, H.; Schrom, E.; Yang, L.; So, J. Y.; Sellner, C.; Gu, Y.; Wang, W.; Kieu, C.; Park, W.; Yang, R.; Wolcott, K.; Livak, F.; Kruhlak, M.; Aprelikova, O.; Gray, J.; Koparde, V.; Moriwaki, Y.; Germain, R.

10.1101/2025.04.16.649000 — cancer biology — Posted on 2025-04-18

2235 Cell-Based Potency Assay for Anti-CD3-Anti-CD19 Diabody

Weiss, T. L.; Paniagua, J.; Johnson, T. M.; Cripe, T. P.; Ralph, P.

10.1101/2025.04.15.648836 — cancer biology — Posted on 2025-04-18

2236 A Computational Framework for Analysis of cfDNA Fragmentation Profiles

Poh, Z. W.; Zhu, G.; Wong, P. M.; Odinokov, D.; Carrie, H.; Lau, Y. T.; Gan, A.; Poon, P.; Tan, P.; Jacobsen Skanderup, A.; Tan, I.

10.1101/2025.04.17.649313 — cancer biology — Posted on 2025-04-18

2237 A microRNA CRISPR screen reveals miR-483-3p as an apoptotic regulator in prostate cancer

Chow, J. T.-S.; Desjardins, A.; Lee, D. K. C.; Grigore, I. A.; Fu, N. J.; Chau, S.; Lee, B. Y.; Gabra, M. M.; Salmena, L.

10.1101/2025.04.16.649147 — cancer biology — Posted on 2025-04-18

2238 Exploring the Anti-Tumor Effects of Brusatol in Aggressive B-Cell Lymphomas

Szmyra-Polomka, M. M.; Haingartner, S.; Jantscher, S.; Bernhart, E. M.; Kovacs-Hajdu, P.; Boskova, V.; Krall, N.; Zupo, A.; Pircher, T.; Pansy, K.; Kloesch, B.; Greinix, H. T.; Beham-Schmid, C.; Vagena, F. R.; Zacharias, M.; Gaksch, L.; Prochazka, K.; Neumeister, P.; Dengler, M. A.; Deutsch, A. J.

10.1101/2025.04.16.649058 — cancer biology — Posted on 2025-04-18

2239 Transcriptional regulators FOXD1 and RBFOX2 contribute to metastatic capacity in BAP1mut uveal melanoma

Brosens, E.; Nguyen, J.; Konemann, N.; van den Bosch, T.; Verdijk, R.; Kilic, E.; van den Bosch, Q.

10.1101/2025.04.14.648661 — cancer biology — Posted on 2025-04-18

2240 Oncogene Silencing via ecDNA Micronucleation

Brueckner, L.; Xu, R.; Tang, J.; Herrmann, A.; Wong, I. T.-L.; Zhang, S.; Tu, F.; Pilon, M.; Kukalev, A.; Pardon, K.; Sidorova, O.; Atta, J.; Yu, Q.; Pradella, D.; Ilic, M.; Novais-Cruz, M.; Kaltenbach, S.; Treue, D.; Giurgiu, M.; Herzog, S.; Hollinger, A.-S.; Fernandez, M.; Becker, F.; Louma, V.-R.; Schmargon, R.; Doerr, J.; Gamlin, D.; Lehmann, A.; Guergen, D.; Richter, M.; Dubois, F.; Simeoni, F.; Pennycook, B. R.; Hamilton, A.; Lindemann, R. K.; Fischer, M.; Bafna, V.; Wahl, G.; Koche, R. P.; Chang, H. Y.; Papathanasiou, S.; Medema, R.; Spanjaard, B.; Ventura, A.; Pombo, A.; Huang, W.; Wer

10.1101/2025.04.15.648906 — cancer biology — Posted on 2025-04-18

2241 A unified eIF1A+ luminal cells-centered hypoxic and "cold" tumor microenvironment promotes PCa progression among different subtypes

Wan, L.; Huang, E.; Xu, Z.; Zheng, B.; Ding, X.; Chu, C.; Wu, T.; Chen, S.; Zhuang, J.; Chen, M.; Na, R.; Ju, S.; Zhang, D.; Li, W.; Cheng, Y.; Xu, B.

10.1101/2025.04.17.649316 — cancer biology — Posted on 2025-04-18

2242 CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance

Watterson, A.; Picco, G.; Veninga, V.; Samarakoon, Y.; Cattaneo, C. M.; Vieira, S. F.; Karakoc, E.; Bhosle, S.; Battaglia, T. W.; Consonni, S.; Halim, T. Y. F.; Voest, E. E.; Garnett, M. J.; Coelho, M. A.

10.1101/2025.04.15.648737 — cancer biology — Posted on 2025-04-18

2243 SKIDA1 transiently sustains MLL::ENL-Expressing hematopoietic progenitors during neonatal stages and promotes B-lineage priming

Mendoza-Castrejon, J.; Yang, W.; Denby, E.; Muthukumar, R.; Casey, E. B.; Patel, R. M.; Tasian, S. K.; Magee, J. A.

10.1101/2025.04.12.648529 — cancer biology — Posted on 2025-04-18

2244 Nucleotide insufficiency induced by p53 deficiency leads to replication stress driving genomic instability

Zaatra, W.; Philippos, G.; Smirnov, P.; Cochavi, S. M.; Otonicar, J.; Chan, M.; Harel, M.; Devens, F.; Eliassaf, A.; Grimes, K.; Irony-Tur Sinai, M.; Sigismondo, G.; Gieiger, T.; Korbel, J.; Krijgsveld, J.; Shalev, O.; Kerem, B.; Ernst, A.

10.1101/2025.04.17.649416 — cancer biology — Posted on 2025-04-18

2245 KDM5B expression is suppressed by MYC in a negative feedback loop to promote cell survival.

Chatterjee, T.; Beffert, E.; Dewson, G. S.; Sullivan, D. K.; Anchang, B.; Sears, R. C.; Liefwalker, D.

10.1101/2025.04.12.648490 — cancer biology — Posted on 2025-04-18

2246 Potentiation of EGFR mutant lung cancer treatment targeting replication stress.

Bhowmick, R.; Turchi, J. J.; Jalal, S. I.

10.1101/2025.04.18.649510 — cancer biology — Posted on 2025-04-18

2247 Isoform switch of CD47 provokes macrophage-mediated pyroptosis in ovarian cancer

Wang, Z.; Yang, L.; Yang, S.; Li, G.; Xu, M.; Kong, B.; Shao, C.; Liu, Z.

10.1101/2025.04.17.649282 — cancer biology — Posted on 2025-04-18

2248 CLM296: a highly selective inhibitor targeting ALDH1A3-driven tumor growth and metastasis in breast cancer

MacLean, M. R.; Bernardoni, B. L.; Fernando, W.; Petrarolo, G.; D Agostino, I.; Dean, C. A.; Venkatesh, J.; Hughes, C. S.; Goralski, K.; Subramanian, G.; Arun, R. P.; Cahill, H. F.; Walker, O.; La Motta, C.; Marcato, P.

10.1101/2025.04.16.649105 — cancer biology — Posted on 2025-04-18

2249 WITHDRAWN: Genomics and reproductive biology of Leptopilina malgretoutensis Buffington, Lue, Davis & Tracey sp. nov. (Hymenoptera: Figitidae): An asexual parasitoid of Caribbean Drosophila

Lindsey, A. R.; Lue, C.-H.; Davis, J. S.; Borjon, L. J.; Mauthner, S. E.; Fricke, L. C.; Eads, L.; Murphy, M.; Drown, M. K.; Faulk, C.; Buffington, M. L.; Tracey, W. D.

10.1101/2025.03.28.645512 — evolutionary biology — Posted on 2025-04-18

2250 Switches from tonic to burst firing enable memory consolidation through late-phase synaptic plasticity

Jacquerie, K.; Tyulmankov, D.; Sacre, P.; Drion, G.

10.1101/2025.04.12.648539 — neuroscience — Posted on 2025-04-18

2251 Metabolic mode estimated by breathing reflects long-term motor memory

Hayashi, T.; Nakano, N.; Washino, S.; Murai, A.

10.1101/2024.06.27.600911 — neuroscience — Posted on 2025-04-18

2252 The effect of illumination cues on color constancy in simultaneous identification of illumination and reflectance changes

Virtanen, L. S.; Olkkonen, M.; Saarela, T. P.

10.1101/2024.12.05.626994 — neuroscience — Posted on 2025-04-18

2253 Brainstem pathology in human narcolepsy: Neurodegeneration in the locus coeruleus in narcoleptic humans, but not in genetically narcoleptic mice or dogs

Thannickal, T. C.; Wu, M.-F.; Cornford, M. E.; Siegel, J.

10.1101/2025.04.12.648456 — neuroscience — Posted on 2025-04-18

2254 Characterising ongoing brain aging and baseline effects from cross-sectional data

Smith, S. M.; Miller, K. L.; Nichols, T. E.

10.1101/2025.01.21.634044 — neuroscience — Posted on 2025-04-18

2255 Concordance of claudin-18.2 expression in biopsy, resection, and recurrent specimens: implications for zolbetuximab therapy in pancreatic ductal adenocarcinoma

Kyuno, D.; Yanazume, K.; Saito, A.; Ono, Y.; Ito, T.; Imamura, M.; Osanai, M.

10.1101/2025.04.11.648482 — pathology — Posted on 2025-04-18

2256 Spatial differentiation of proteome in cervical cancer tissues using Imaging Mass Spectrometry

Baliyan, A.; Mohapatra, I.; Paul, S.; Safiriyu, A. A.; Mondal, S. K.; Mishra, D.; Mandal, A. K.

10.1101/2025.04.12.648495 — cancer biology — Posted on 2025-04-18

2257 Microglial Fructose Metabolism Is Essential for Glioblastoma Growth

Billingham, L. K.; Delay, S. L.; Tripathi, S.; Olson, I. E.; Zilinger, K.; Subbiah, J.; Wang, Z.; Sadagopan, N. S.; Chia, T.-Y.; Najem, H.; Cognet, G.; Katz, J. L.; Vazquez-Cervantes, G. I.; Wang, S.; Wan, H.; Murphy, A. R.; Lipshutz, A. B.; Duffy, J. T.; Valyasnikova, I. V.; Zhang, P.; Heiland, D. H.; Ahmed, A. U.; Lee-Chang, C.; Heimberger, A. B.; Perry, J. S.; Muir, A.; Chandel, N. S.; Miska, J.

10.1101/2025.04.12.646414 — cancer biology — Posted on 2025-04-18

2258 Whole-genome prediction of bacterial pathogenic capacity on novel bacteria using protein language models, with PathogenFinder2

Ferrer Florensa, A.; Almagro Armenteros, J. J.; Kaas, R. S.; Clausen, P. T.; Nielsen, H.; Rost, B.; Aarestrup, F. M.

10.1101/2025.04.12.648497 — bioinformatics — Posted on 2025-04-18

2259 DTractor enhances cell type deconvolution in spatial transcriptomics by integrating deep neural networks, transfer learning, and matrix factorization

Kweon, Y. J.; Liu, C.; Fonseca, G.; Ding, J.

10.1101/2025.04.12.648541 — bioinformatics — Posted on 2025-04-18

2260 The LINC complex component Kms1 and CENP-B protein Cbp1 cooperate to enforce faithful homology-directed DNA repair at the nuclear periphery in S. pombe

Laffitte, A.; Lin, D.; Tian, Y. J.; Liu, N.; Lusk, C. P.; Mochrie, S.; King, M. C.

10.1101/2025.04.12.648544 — genetics — Posted on 2025-04-18

2261 Spatial and Temporal Patterns of Wolf Occurrences on the Summer Range of the Eastern Migratory Cape Churchill Caribou Population in the Hudson Bay Lowlands of Manitoba

Brook, R. K.; Harris, K.; Clark, D.; Lochansky, C.; Colpitts, J.

10.1101/2025.04.11.648486 — ecology — Posted on 2025-04-18

2262 The influence of biosecurity on the diversity and management of a 120-year old joint insect-fungus pest invasion

Eshetu, F. B.; Barnes, I.; Nahrung, H. F.; Slippers, B.; Fitza, K. N.

10.1101/2025.04.12.647806 — ecology — Posted on 2025-04-18

2263 Discovery of D2469079A, A novel selective Toll-Like Receptor 7/8 Antagonist with Brain Penetrance

Deng, X.; Zhang, X.; Tian, W.; Xiao, D.; Du, Z.; Wang, Y.; Cao, S.; Li, B.; Zhao, Y.; Chen, H.; Su, Y.; Zhou, Y.

10.1101/2025.04.12.648517 — immunology — Posted on 2025-04-18

2264 Selective decoupling of IgG1 binding to viral Fc receptorsrestores antibody-mediated NK cell activation against HCMV-infected cells

Qerqez, A. N.; Hoffmann, K.; Lee, A. G.; Pareek, S.; Hager, K. M.; Mishra, A. K.; Delidakis, G.; Bentley, K.; Kerr-Jones, L.; Cabrera, M.; Nguyen, T.; Goettler, R. L.; Chowdhury, A.; Kolb, P.; Hengel, H.; Georgiou, G.; McLellan, J. S.; Stanton, R.; Nguyen, A. W.; Maynard, J. A.

10.1101/2025.04.12.647817 — immunology — Posted on 2025-04-18

2265 Task-induced 1/f slope modulation as a paradigm-independent marker of cognitive control in multiple sclerosis

Akbarian, F.; Gyurkovics, M.; Dhooghe, M. B.; Dhaeseleer, M.; Nagels, G.; Van Schependom, J.

10.1101/2025.04.11.648423 — neuroscience — Posted on 2025-04-18

2266 Deep learning using structural MRI massively improves prediction accuracy of body mass index

Cooper, A.; Elsayed, M.; Owens, M.; MacKillop, J.

10.1101/2025.04.11.648433 — neuroscience — Posted on 2025-04-18

2267 The Ventral Attention Network Mediates Attentional Reorienting to Cross-Modal Expectancy Violations: Evidence from EEG and fMRI

Das, S.; Meyyappan, S.; Bekker, E.; Corina, S.; Ding, M.; Mangun, G. R.

10.1101/2025.04.11.648474 — neuroscience — Posted on 2025-04-18

2268 Dissociating physiological ripples and epileptiform discharges with vision transformers

Zhang, D.; Kleen, J.

10.1101/2025.04.11.648468 — neuroscience — Posted on 2025-04-18

2269 An enteric neuron-expressed variant ionotropic receptor detects ingested salts to regulate salt stress resistance

Yeon, J.; Chen, L.; Krishnan, N.; Bates, S.; Porwal, C.; Sengupta, P.

10.1101/2025.04.11.648259 — neuroscience — Posted on 2025-04-18

2270 DICAR-JP Regulates Ribosome Migration, a New Theory of Mitochondrial Protein Production

Zhang, J.; Yu, X.; Zheng, S.; Qiao, G.; Zhang, C.; Tang, S.; Gao, X.; Wang, Y.; Yu, Y.; Cheng, J.; Lei, M.; Li, P.; Yang, Y.; Zhang, C.; Yuan, Q.

10.1101/2025.04.11.648480 — pharmacology and toxicology — Posted on 2025-04-18

2271 Generating the head direction signal: Two types of head direction cells in the lateral mammillary and dorsal tegmental nuclei.

Taube, J. S.; Butler, W. M.; Dumont, J. R.; Graham, J. A.; Marcroft, J. L.; Shinder, M. E.; Stackman, R. W.; Yoder, R. M.

10.1101/2025.04.11.648409 — neuroscience — Posted on 2025-04-18

2272 Identifying non-coding variant effects at scale via machine learning models of cis-regulatory reporter assays

Butts, J. C.; Rong, S.; Gosai, S. J.; Castro, R. I.; Noon, M.; Adeniran, K.; Ghosh, R.; Sabeti, P. C.; Tewhey, R.; Reilly, S. K.

10.1101/2025.04.16.648420 — genomics — Posted on 2025-04-18

2273 A rapid transfer of virions coated with heparan sulfate from the ECM to cell surface CD151 defines a step in the human papillomavirus infection cascade

Massenberg, A.; Homsi, Y.; Schneider, C. N.; Mikulicic, S.; Döring, T.; Florin, L.; Lang, T.

10.1101/2025.04.17.649398 — microbiology — Posted on 2025-04-18

2274 Isolation and Probiotic Characterization of Lactic Acid Bacteria from the Phylloplanes of Edible and Culinary Leaves

S, S.; B, U. K.; V C, S.; Das, U.

10.1101/2025.04.17.649317 — microbiology — Posted on 2025-04-18

2275 Parasite virulence in coinfected hosts: the importance of infection order

Sorci, G.; Dusuel, A.; Bourbon, L.; Groetz, E.; Pernet, N.; Rialland, M.; Roche, B.; Faivre, B.

10.1101/2025.03.13.642968 — evolutionary biology — Posted on 2025-04-18

2276 EssentCell: Discovering Essential Evolutionary Relations in Noisy Single-Cell Data

Liyanage, A.; Burger, R.; Shi, A.; Sopp, B.; Zhu, B.; Mumey, B.

10.1101/2025.04.12.648524 — cancer biology — Posted on 2025-04-18

2277 Exploiting functional regions in the viral RNA genome as druggable entities

Luo, D.; Zheng, Y.; Huang, Z.; Wen, Z.; Guo, L.; Deng, Y.; Li, Q.; Bai, Y.; Haider, S.; Wei, D.

10.1101/2024.08.11.607475 — genomics — Posted on 2025-04-18

2278 The evolution of gene expression in seasonal environments

Kudo, S. N.; Ikezaki, Y.; Kusumi, J.; Hirakawa, H.; Isobe, S.; Satake, A.

10.1101/2025.03.25.645377 — evolutionary biology — Posted on 2025-04-18

2279 Investigating the determinants of performance in machine learning for protein fitness prediction

Sandhu, M.; Mater, A. C.; Matthews, D. S.; Spence, M. A.; Lenskiy, A. A.; Jackson, C. J.

10.1101/2020.09.30.319780 — synthetic biology — Posted on 2025-04-18

2280 Methylation reprogramming associated with aggressive prostate cancer and ancestral disparities

Hayes, V. M.; Craddock, J.; Lutsik, P.; Soh, P.; Louw, M.; Hasan, M. M.; Patrick, S.; Mutambirwa, S.; Stricker, P.; Förtsch, H.; Bornman, M. R.; Gerhauser, C.

10.1101/2025.04.16.649098 — genomics — Posted on 2025-04-18

2281 Spatio-Temporal Control of GFP-tagged Protein Degradation in the Mouse

Prado-Mantilla, A.; Lechler, T.

10.1101/2025.04.17.649420 — genetics — Posted on 2025-04-18

2282 RBMX2: A Pivotal Regulator Linking Mycobacterium bovis Infection to Epithelial-Mesenchymal Transition and Lung Cancer Progression

Wang, C.; Peng, Y.; Yang, H.; Jiang, Y.; Khalid, A. K.; Zhang, K.; Xie, S.; Bermudez, L.; Yang, Y.; Zhang, L.; Chen, H.; Guo, A.; Chen, Y.

10.1101/2025.04.15.648920 — microbiology — Posted on 2025-04-18

2283 Mis-localization of PBPs in Staphylococcus aureus gdpP mutant contributes to β-lactam resistance and surface protein cross-wall trafficking

Jia, Y.; Zhang, R.; Scaffidi, S. J.; Yu, W.

10.1101/2025.04.15.649054 — microbiology — Posted on 2025-04-18

2284 Genomic and Functional Characterization of Priestia megaterium MOD5IV isolated from the rhizosphere of Caesalina spinosa (Mol.): Enhancing Phytoremediation Potential in Multi-Metal Contaminated Soils

Pouchucq, L. A.; Marcoleta, A. E.; Rojas, C.; Arce, H.; Becerra, C.; Bahamondes, C.; Lobos-Ruiz, P.

10.1101/2025.04.15.648928 — microbiology — Posted on 2025-04-18

2285 Multivalent interaction induces phase separation and formation of more toxic aggregates of α-syn in a yeast model of Parkinson's disease

Chattopadhyay, K.; Jain, R.; Sharavanakkumar, S.

10.1101/2025.04.14.648683 — biophysics — Posted on 2025-04-18

2286 Domestication shaped the chromatin landscape of grain amaranth

Graf, C.; Winkler, T. S.; Maughan, P. J.; Stetter, M. G.

10.1101/2025.04.17.649361 — genomics — Posted on 2025-04-18

2287 SlHSFB3a developmentally regulates lateral root formation by modulating auxin signaling in tomato.

Majee, A.; Sairem, B.; Kumar, V.; Sane, A. P.; Sane, V. A.

10.1101/2025.04.15.648910 — plant biology — Posted on 2025-04-18

2288 Balancing nutrient remobilization and photosynthesis: the dual role of lupin cotyledons after germination

Angermann, C.; Heinemann, B.; Bueno Nogueira, B.; Mai, H.-J.; Bauer, P.; Hildebrandt, T. M.

10.1101/2025.04.15.648908 — plant biology — Posted on 2025-04-18

2289 Relationship Between Open Reading Frame 320, a Gene Causing Male Sterility in Tomatoes, and Cytoplasmic Male Sterility in Potatoes

Nakajima, R.; Sanetomo, R.; Shirasawa, K.; Ariizumi, T.; Kuwabara, K.

10.1101/2025.04.17.649265 — plant biology — Posted on 2025-04-18

2290 INDETERMINATE DOMAIN-DELLA protein interactions orchestrate gibberellin-mediated cell elongation in wheat and barley

Sokolowska, P.; Jost, M.; Buss, W.; Ford, B.; Chandler, P.; Spielmeyer, W.; Phillips, A.; Huttly, A.; Tarkowska, D.; Alarcon-Reverte, R.; Clark, S.; Pearce, S.; Hedden, P.; Thomas, S.

10.1101/2025.04.17.649374 — plant biology — Posted on 2025-04-18

2291 Mobile immune signals potentiate salicylic acid-mediated plant immunity via WRKY38/62 transcription factors

Mason, R. O.; Grey, H.; Spoel, S. H.

10.1101/2025.04.17.649115 — plant biology — Posted on 2025-04-18

2292 Evolution under Domestication: Genetic differentiation in black soldier fly (Hermetia illucens) populations subjected to recent selective breeding

Silvaraju, S.; Loh, R. K.; Kittelmann, S.; Puniamoorthy, N.

10.1101/2025.04.14.648847 — evolutionary biology — Posted on 2025-04-18

2293 Ancient stickleback genomes reveal the chronology of parallel adaptation

Laine, J.; Nickel, J. H.; Romundset, A.; Foote, A.

10.1101/2025.04.14.648705 — evolutionary biology — Posted on 2025-04-18

2294 Patterns of gene family evolution and selection across Daphnia

Murray, C. S.; Bergland, A. O.

10.1101/2025.04.14.648758 — evolutionary biology — Posted on 2025-04-18

2295 Integrating ethnolinguistic and archaeobotanical data to uncover the origin and dispersal of cultivated sorghum in Africa: a genomic perspective

Gilabert, A.; Deu, M.; Champion, L.; Cubry, P.; Donkpegan, A.; Rami, J.-F.; Pot, D.; Vigouroux, Y.; Leclerc, C.

10.1101/2025.04.16.648676 — evolutionary biology — Posted on 2025-04-18

2296 Multiple instances of river-lake introgression in the adaptive radiation of sailfin silversides in Wallace's Dreampond

De Keyzer, E. L. R.; Herder, F.; Boehne, A.; Campuzano Jimenez, F.; Burskaia, V.; Kukowka, S.; Tracey, A.; Denton, A. L.; Oatley, G.; Tree of Life programme, ; Scientific Operations: DNA Pipelines collective, ; Core Informatics collective, ; Mokodongan, D. F.; Wowor, D.; Svardal, H.

10.1101/2025.04.16.648611 — evolutionary biology — Posted on 2025-04-18

2297 Recent divergence and microgeographic genetic structure in an endangered Australian songbird: the southern black-throated finch

Hooper, D. M.; Lopez, K. A.; Butcher, B. G.; Lovette, I. J.; Griffith, S. C.

10.1101/2025.04.17.649380 — evolutionary biology — Posted on 2025-04-18

2298 Empirical validation of the nearly neutral theory at divergence and population genomic scale using 150 mammals genomes

Bastian, M.; Enard, D.; lartillot, n.

10.1101/2025.04.17.649326 — evolutionary biology — Posted on 2025-04-18

2299 Innovative airborne DNA approach for monitoring honey bee foraging and health

Pepinelli, M.; Biganzoli-Rangel, A. J.; Lunn, K.; Arteaga, P.; Borges, D.; Zayed, A.; Clare, E.

10.1101/2025.04.17.649222 — ecology — Posted on 2025-04-18

2300 Dating and quantifying past gene flow due to hybridization events in Iberian chubs

Faustino, E.; Mendes, S. L.; Carvalho, J.; Perea, S.; Doadrio, I.; Feulner, P. G. D.; Sousa Santos, C.; Sousa, V. C.

10.1101/2025.04.13.648569 — evolutionary biology — Posted on 2025-04-17

2301 Sub-optimal temperature leads to tighter coupling between photosynthetic electron transport and CO2 assimilation under fluctuating light in maize.

Rodrigues Gabriel Sales, C.; Arrivault, S.; Tonetti, T.; Clapero, V.; Vath, R. L.; Cubas, L. A.; Stitt, M.; Kromdijk, J.

10.1101/2025.04.12.648513 — plant biology — Posted on 2025-04-17

2302 Expression levels of the Band-7 protein FLOTILLIN modulate salt tolerance, growth and development in the moss Physcomitrium patens

Csicsely, E.; Noor, N.; Mühlbauer, S.; Kunz, H.-H.; Schwenkert, S.; Lehmann, M.; Klingl, A.; Top, O.; Frank, W.

10.1101/2025.04.14.648360 — plant biology — Posted on 2025-04-17

2303 Human Papillomavirus Genomes Associate with Active Host Chromatin during Persistent Viral Infection

Warburton, A.; Markowitz, T. E.; Miranda, J. L.; Majumder, K.; McBride, A. A.

10.1101/2025.04.15.649012 — genomics — Posted on 2025-04-17

2304 Analysis of 14q12 microdeletions reveals novel regulatory loci for the neurodevelopmental disorder-related gene, FOXG1

Ramamurthy, A.; Bandouil, M. D.; Aluru, L.; Yoon, E.; Bodkin, N.; Cheng, J. Z.; Biar, C. G.; Calhoun, J. D.; Carvill, G. L.

10.1101/2025.04.11.648472 — genetics — Posted on 2025-04-17

2305 Tracing the evolution of prestin's area-motor activity through ancestral sequence reconstruction and structural modeling

Fuentes-Ugarte, N.; Ruiz-Rojas, T.; Ruiz-Fernandez, A.; Garate, J. A.; Castro-Fernandez, V.; Araya-Secchi, R.

10.1101/2025.04.11.648445 — evolutionary biology — Posted on 2025-04-17

2306 Evolutionary dynamics under demographic fluctuations: beyond the effective population size

Jain, K.

10.1101/2025.04.12.648494 — evolutionary biology — Posted on 2025-04-17

2307 Mathematically modelling the population dynamics of CRISPR gene drive systems in the pine pest Sirex noctilio

Strydom, H.; Ouifki, R.; Chapwanya, M.; Slippers, B.

10.1101/2025.04.12.648502 — ecology — Posted on 2025-04-17

2308 Cellular type is a major determinant of R-loop genomic distribution

Oleynikova, K.; Zhigalova, N.; Hutchins, A.; Ruzov, A.

10.1101/2025.04.17.649299 — molecular biology — Posted on 2025-04-17

2309 Real-world testing of the durability claims of a commercially available spray-on surface biocide

Saseendran Nair, S.; Cavadino, A.; Swift, S.; Wiles, S.

10.1101/2025.04.17.649382 — microbiology — Posted on 2025-04-17

2310 Gastrointestinal colonization as a source of Staphylococcus aureus in atopic dermatitis

Karagounis, T. K.; Putzel, G.; Podkowik, M.; Shenderovich, J.; Tillman, A.; Morales, S. M.; Gaylord, A.; Srivastava, A.; Arguelles, N.; Slater, H.; Ahmed, A. N.; Xing, Y.; Samhadaneh, N. M.; Needle, C. D.; Ulrich, R. J.; Oza, V.; Schluter, J.; Naik, S.; Trasande, L.; Pironti, A.; Torres, V. J.; Shopsin, B.

10.1101/2025.04.17.648849 — microbiology — Posted on 2025-04-17

2311 Loss of MeCP2 leads to sleep deficits that are time-of-day dependent and worsen with sleep deprivation

Al Maghribi, A.; Rempe, M. J.; Medina, E.; Ford, K. E.; Singletary, K. G.; Ottaway, C.; Peixoto, L.

10.1101/2025.04.16.649209 — neuroscience — Posted on 2025-04-17

2312 Transcriptional and neuroprotective effects of hexokinase-2 inhibitors administered afterstroke

Won, S. J.; Uruk, G.; Mai, N.; Tu, C.-L.; Ogut, D.; Asatryan, S.; Mocanu, E.; Shon, R.; Kim, K.; Awakoaiye, K.; Arkelius, K.; Chang, W.; Singhal, N. S.; Swanson, R. A.

10.1101/2025.04.11.648425 — neuroscience — Posted on 2025-04-17

2313 Expanding the Repertoire of Photoswitchable Unnatural Amino Acids for Enzyme Engineering

Hiefinger, C.; Marcon, M.; Pape, V.; Casadevall, G.; Lahmy, R.; Nazet, J.; Bartl, M.; Bruckmann, A.; Osuna, S.; Koenig, B.; Hupfeld, A.

10.1101/2025.04.17.649278 — synthetic biology — Posted on 2025-04-17

2314 Acetate metabolism during xylose fermentation enhances 3-hydroxypropionic acid production in engineered acid-tolerant Issatchenkia orientalis

Jeong, D.; Lee, D.; Liu, J.; Kim, S. R.; Jin, Y.-S.; Zhao, J.; Oh, E. J.

10.1101/2025.04.17.649204 — synthetic biology — Posted on 2025-04-17

2315 Regulation of the MDM2-p53 Nexus by a Nuclear Phosphoinositide and Small Heat Shock Protein Complex

Lee, J. H.; Chen, M.; Wen, T.; Anderson, R. A.; Cryns, V. L.

10.1101/2025.04.11.648454 — cancer biology — Posted on 2025-04-17

2316 Combining Multi-site FRAP and HILO-TIRF microscopy using a Spatial Light Modulator

Upadhya, A.; Lim, Y. J.; Lee, W. M.

10.1101/2025.04.15.649016 — biophysics — Posted on 2025-04-17

2317 Recurrent chromosome destabilization through repeat-mediated rearrangements in a fungal pathogen

Fouche, S.; Oggenfuss, U.; McDonald, B. A.; Croll, D.

10.1101/2023.07.14.549097 — genomics — Posted on 2025-04-17

2318 PCP-assisted hydration facilitates robust giant vesicle formation in solutions of physiological ionic strengths

Cooper, A.; Vijayananda, V.; Pazzi, J.; Subramaniam, A. B.

10.1101/2025.02.14.638371 — biophysics — Posted on 2025-04-17

2319 DSSP 4: FAIR annotation of protein secondary structure

Hekkelman, M. L.; Alvarez Salmoral, D.; Perrakis, A.; Joosten, R. P.

10.1101/2025.04.11.648460 — bioinformatics — Posted on 2025-04-17

2320 An evolutionary shift to prioritizing mating over care is associated with consistently high androgen levels in male threespine stickleback

Maciejewski, M. F.; Bell, A. M.

10.1101/2025.04.11.648435 — animal behavior and cognition — Posted on 2025-04-17

2321 Direct genome sequencing of Leishmania tropica in tissues of Moroccan patients with cutaneous leishmaniasis reveals micro-focal transmission underlain by clonal and sexual reproduction modes

Daoui, O.; Monsieurs, P.; TALIMI, H.; Spaeth, G. F.; Dujardin, J.-C.; Heeren, S.; Lemrani, M.; Domagalska, M. A.

10.1101/2025.04.17.649263 — genomics — Posted on 2025-04-17

2322 amr.watch - monitoring antimicrobial resistance trends from global genomics data

David, S.; Diaz Caballero, J.; Couto, N.; Abudahab, K.; Fareed-Alikhan, N.; Yeats, C.; Underwood, A.; Molloy, A.; Connor, D.; Shane, H. M.; Ashton, P. M.; Grundmann, H.; Holden, M. T.; Feil, E. J.; Sia, S. B.; Donado-Godoy, P.; Lingegowda, R. K.; Okeke, I. N.; Argimon, S.; Aanensen, D. M.; NIHR Global Health Research Unit on Genomics and enabling data for the Surveillance of AMR,

10.1101/2025.04.17.649298 — genomics — Posted on 2025-04-17

2323 Shift in gut microbiota composition and mitigation of diet-induced atherogenesis in mice after prolonged consumption of a traditionally fermented soybean

Goutam Singh, M.; Bora, H. K.; Wahengbam, R.

10.1101/2025.04.16.649253 — microbiology — Posted on 2025-04-17

2324 Intercellular communication in the fern endosymbiotic cyanobacterium Nostoc azollae

Sarasa-Buisan, C.; Nieves-Morion, M.; Lindblad, P.; Nierzwicki-Bauer, S.; Schluepmann, H.; Flores, E.

10.1101/2025.04.17.649285 — microbiology — Posted on 2025-04-17

2325 Harmful algal bloom species Microcystis aeruginosa releases thiamin antivitamins to suppress competitors

YAZDANI, M.; Suffridge, C.; Liu, F.; Costello, C. M.; Zhou, Z.; St. John, G.; Bhawal, R.; Zhang, S.; Coates, G.; Wu, M.; Ahner, B.

10.1101/2025.04.17.649140 — microbiology — Posted on 2025-04-17

2326 Polar localization of putative phospholipid transporters in Escherichia coli

Tan, W. B.; Chong, Z.-S.; Cheong, J. W. M.; Yeow, J.; Chng, S.-S.

10.1101/2025.04.17.649288 — microbiology — Posted on 2025-04-17

2327 Mammarenavirus Z protein myristoylation and oligomerization are not required for its dose-dependent inhibitory effect on vRNP activity

Witwit, H.; de la Torre, J. C.

10.1101/2025.04.17.649453 — microbiology — Posted on 2025-04-17

2328 Pharmacological interrogation of crosstalk between TLR signaling and stress granules reveals a compound with antiviral effect.

Aditi, A.; Lamichhane, P. P.; Xie, X.; Samir, P.

10.1101/2025.04.11.648452 — immunology — Posted on 2025-04-17

2329 Initial signs of learning: Decoding newly-learned vocabulary from neural patterns in novice sign language learners

Hillis, M. E.; Kraemer, D. J. M.

10.1101/2025.04.11.648265 — neuroscience — Posted on 2025-04-17

2330 Protective effects of central leptin on whole-body energy homeostasis upon acute olanzapine exposure

Asgariroozbehani, R.; Singh, R.; Wu, S.; Imami, A. S.; Hamoud, A.-r.; Agarwal, S. M.; Baranowski, B. J.; Jeromson, S.; Bernardo, A.; Prevot, T. D.; Wright, D. C.; Giacca, A.; Mccullumsmith, R. E.; Pereira, S.; Hahn, M. K.

10.1101/2025.04.11.648424 — neuroscience — Posted on 2025-04-17

2331 Targeted gene transfer into developmentally defined cell populations of the primate brain

Ribeiro Gomes, A. R.; Hamel, N.; Mastwal, S.; Wright, N.; Ide, D. C.; Richie, C. T.; Usdin, T. B.; Wang, K. H.; Leopold, D. A.

10.1101/2025.04.11.648413 — neuroscience — Posted on 2025-04-17

2332 A test of long-term and dose-dependent effects of fluoxetine exposure on the velocity of the invasive crayfish Procambarus clarkii

Oliveira, D. F.; Banha, F.; Anastacio, P.; Soares, M. S.

10.1101/2025.04.11.648412 — neuroscience — Posted on 2025-04-17

2333 Validation and pre-analytical considerations for processing cerebrospinal fluid samples on a high-throughput proximity extension assay platform

Hyde, M.; Cunningham, M.; Chai, X.; Hu, H. A.; Lu, C.; Vasanthakumar, A.

10.1101/2025.04.11.648439 — neuroscience — Posted on 2025-04-17

2334 The Product neutrality function defining genetic interactions emerges from mechanistic models of cell growth

Fuentes Valenzuela, L.; Francois, P.; Skotheim, J. M.

10.1101/2024.11.29.626097 — systems biology — Posted on 2025-04-17

2335 A selective inhibitor of oncogenic JNK signalling perturbs metastatic outgrowth of triple-negative breast cancer through metabolic blockade

Latham, S. L.; O'Donnell, Y. E.; Girgis-Cook, O.; Clearwater, M. S.; Bryce, N. S.; Mok, E.; Lynn, S. A.; Ni, J.; Alfred, S.; Leong, K. H.; Quek, L.-e.; Murphy, K.; Pantarelli, C.; Dragutinovic, I.; Naeini, M.; Thiel, C.; Cadell, A.; Phimmachanh, M.; Sharma, R.; Millar, E.; Han, J. Z.; Hastings, J. F.; Koehler, M.; Brummer, T.; Young, A.; O'Toole, S.; Oakes, S.; Hardeman, E.; Lock, J.; Kolch, W.; Taft, M. H.; Nobis, M.; Goldstein, L.; Timpson, P.; Parker, B. L.; Holst, J.; Gunning, P. W.; Cox, T. R.; Morris, J. C.; Croucher, D. R.

10.1101/2025.04.16.649243 — cancer biology — Posted on 2025-04-17

2336 Loss of CARM1 alters the developmental programming of Glioma stem-like cells and creates a druggable NGFR/NTRK dependency

Young, D.; Aguilan, J.; Cutler, R.; Stransky, S.; DeAngelo, J.; Roth, J.; Malachowska, B.; Vercellino, J.; Bell, B.; Shechter, D.; Tofilon, P.; Phillips, R.; Guha, C.; Sidoli, S.

10.1101/2025.04.11.647869 — cancer biology — Posted on 2025-04-17

2337 Studying cis-regulatory heterogeneity in single-cells at allelic resolution

Petrova, V.; Niu, M.; Vierbuchen, T.; Wong, E. S.

10.1101/2025.04.16.649227 — bioinformatics — Posted on 2025-04-17

2338 stPipe: A flexible and streamlined R/Bioconductor pipeline for preprocessing sequencing-based spatial transcriptomics data

Xu, Y.; Sargeant, C. J.; You, Y.; You, Y.; Su, S.; Wang, C.; Tian, L.; Chen, Y.; Ritchie, M. E.

10.1101/2025.04.16.649254 — bioinformatics — Posted on 2025-04-17

2339 Efficient near telomere-to-telomere assembly of Nanopore Simplex reads

Cheng, H.; Qu, H.; McKenzie, S.; Lawrence, K. R.; Windsor, R.; Vella, M.; Park, P. J.; Li, H.

10.1101/2025.04.14.648685 — bioinformatics — Posted on 2025-04-17

2340 A heat method to interpolate z-stacked cell images that preserves interfaces without explicit identification of object boundaries

Elbert, D. L.

10.1101/2025.04.11.648268 — bioengineering — Posted on 2025-04-17

2341 CRISPR-Cas9 trans-cleavage is hindered by a closed R-loop, an elongated spacer, and an inactive HNH domain

Montagud-Martinez, R.; Ruiz, R.; Baldanta, S.; Delicado-Mateo, R.; Rodrigo, G.

10.1101/2025.04.17.649303 — biochemistry — Posted on 2025-04-17

2342 Enhancing the protein fitness of interferon-lambda through computational design and glyco-engineering for prophylactic nasal drugs against respiratory viruses

Yun, J.; Yang, S.; Kwon, J. H.; Vecchietti, L. F.; Cha, M.; Chung, H. J.; Oh, J. E.; Kim, H. M.

10.1101/2025.04.16.649247 — biochemistry — Posted on 2025-04-17

2343 Quantifying evolution of SNPs that affect RNA secondary structure in Arabidopsis thaliana genes

Martin, G. T.; Fiscus, C. J.; Gaut, B. S.

10.1101/2024.09.27.615253 — genomics — Posted on 2025-04-17

2344 Snapshot of Defense Systems in Multidrug Resistant Klebsiella pneumoniae

Senbadejo, T. Y.; Osei, S. N.; Isawumi, A.

10.1101/2025.04.16.649094 — genomics — Posted on 2025-04-17

2345 High-performance genetically-encoded green and red fluorescent biosensors for pyruvate

Imai, S.; Hario, S.; Suerte, C.; Yamaguchi, I.; Sakoi, K.; Terai, T.; Takahashi-Yamashiro, K.; Campbell, R. E.

10.1101/2025.04.17.649293 — molecular biology — Posted on 2025-04-17

2346 Deletion of a KSF Motif Attenuates NSP1 Host Cell Translation Shutoff and Impairs SARS-CoV-2 Virulence

Ye, C.; Ezzatpour, S.; Imbiakha, B.; Jackson, N.; Cagatay, T.; Cupic, A.; Miorin, L.; Choi, A.; Buchholz, D. W.; Carter, J.; Sahler, J.; Olarte-Castillo, X. A.; Jager, M. C.; Whittaker, G. R.; August, A.; Fontoura, B.; Garcia-Sastre, A.; Martinez-Sobrido, L.; Aguilar, H. C.

10.1101/2025.04.16.649178 — microbiology — Posted on 2025-04-17

2347 Metabolism of Lactobacillus and Gardnerella vaginalis in vaginal defined media

Horrocks, V.; Hind, C. K.; Sutton, J. M.; Tribe, R. M.; Mason, A. J.

10.1101/2025.04.17.649369 — microbiology — Posted on 2025-04-17

2348 ZFT is the major iron and zinc transporter in Toxoplasma gondii

Aghabi, D.; Gallego Rubio, C.; Cortijo Martinez, M.; Pouzache, A.; Gibson, E. J.; Pagura, L.; Harding, C. R.

10.1101/2025.04.17.649150 — microbiology — Posted on 2025-04-17

2349 Ex vivo recapitulation of intramuscular mRNA vaccination with naive and recall antigens using a human Lymphoid Follicle Chip platform

Zhai, Y.; Ku, M. W.; Yang, K.; Patil, A.; Prabhala, P.; He, L.; Man, Y.; Spörri, S. B.; Gharpure, S.; Isaacs, A. R.; Ferdosi, S.; Pitek, A.; Maruggi, G.; Bertholet, S.; Firestone, J.; Mousavi, K.; Miller, E.; Luisi, K.; Hellman, C. A.; Williams, L. D.; Tomaras, G. D.; Yin, P.; Gygi, S.; McAuliffe, J.; Ingber, D. E.; Goyal, G.

10.1101/2025.04.16.649172 — immunology — Posted on 2025-04-17

2350 15-PGDH inhibition promotes hematopoietic recovery and enhances HSC function during aging

Chaudhary, R.; Cordova, B. A.; Hong, M.; Klein, B. R.; Contreras, L. A.; Rashmil, R.; Goshevski, F.; Smith, J. N.; Taylor, D.; Pieper, A. A.; Markowitz, S. D.; Desai, A. B.

10.1101/2025.04.11.648417 — immunology — Posted on 2025-04-17

2351 A lack of distinct cell identities in single-cell measurements: revisiting Waddington's landscape

Sparta, B.; Hamilton, T.; Hughes, S.; Natesan, G.; Deeds, E. J.

10.1101/2022.06.03.494765 — systems biology — Posted on 2025-04-17

2352 Engineered protein circuits for cancer therapy

Lu, A. C.; Moeller, L.; Moore, S.; Xia, S.; Ho, K.; Zhang, E.; Budde, M. W.; Larson, H.; Ahmed Diaz, A.; Gu, B.; Linton, J. M.; Klock, L.; Flynn, M. J.; Gao, X. J.; Siegwart, D. J.; Zhu, H.; Elowitz, M. B.

10.1101/2025.04.16.647665 — synthetic biology — Posted on 2025-04-17

2353 A transcriptional dissection of the petty spurge (Euphorbia peplus L.) reproductive structure

Johnson, A. R.; Bao, A.; Frank, M. H.

10.1101/2024.05.06.592779 — plant biology — Posted on 2025-04-17

2354 Binder and monomer valencies determine the extent of collapse and reswelling of chromatin

Guha, S.

10.1101/2024.08.30.610569 — biophysics — Posted on 2025-04-17

2355 Exploring Diverse Binding Mechanisms of Broadly Neutralizing Antibodies S309, S304, CYFN-1006 and VIR-7229 Targeting SARS-CoV-2 Spike Omicron Variants: Integrative Computational Modeling Reveals Balance of Evolutionary and Dynamic Adaptability in Shaping Molecular Determinants of Immune Escape

Alshahrani, M.; Parikh, V.; Foley, B.; Verkhivker, G.

10.1101/2025.04.15.649027 — biophysics — Posted on 2025-04-17

2356 Distinct tumor-immune ecologies in NSCLC patients predict progression and define a clinical biomarker of therapy response

Prabhakaran, S.; Gatenbee, C.; Robertson-Tessi, M.; Gray, J.; Antonia, S.; Beg, A. A.; Gatenby, R. A.; Anderson, A. R. A.

10.1101/2022.10.22.513219 — cancer biology — Posted on 2025-04-17

2357 Clinico-genomic features predict distinct metastatic phenotypes in cutaneous melanoma

Aprati, T. J.; Day, C.-P.; Lee, D.; Pan, A.; Jee, J.; Tarantino, G.; Manos, M. P.; Faulkner, H.; Holovatska, M. M.; Khaddour, K.; Feng, C. H.; Burke, K. P.; Glettig, M.; Weaver Ohler, Z.; El Meskini, R.; Boland, G. M.; Hodi, F. S.; Haq, R.; Shoushtari, A. N.; Schultz, N.; Ishizuka, J.; Gusev, A.; Griffin, M.; Kehl, K. L.; Liu, D.

10.1101/2025.01.24.633441 — cancer biology — Posted on 2025-04-17

2358 Prediction of fast subcellular calcium signals based on label-free second harmonic generation microscopy measurements

Georgiev, T.

10.1101/2023.04.03.535276 — bioinformatics — Posted on 2025-04-17

2359 GraphVelo allows for accurate inference of multimodal velocities and molecular mechanisms for single cells

Chen, Y.; Zhang, Y.; Gan, J.; Ni, K.; Chen, M.; Bahar, I.; Xing, J.

10.1101/2024.12.03.626638 — bioinformatics — Posted on 2025-04-17

2360 GESIAP3.0: Sensor-based Image Analysis Program for Transmission Visualization In Vivo

Zhu, R. E.; Diao, X.; Liu, X.; Ru, Q.; Wu, Z.; Zhang, Z.; Looger, L.; Zhu, J.

10.1101/2024.10.28.620522 — bioengineering — Posted on 2025-04-17

2361 Smoothened inhibition of PKA at cilia transduces Hedgehog signals

Nguyen, T. D.; Konjikusic, M. J.; Del Castillo, L. M.; Reiter, J. F.

10.1101/2025.04.01.646243 — biochemistry — Posted on 2025-04-17

2362 Screening analysis of light-responsive phenotype of leaf bacteria

Iguchi, H.; Kanagasaki, M.; Ishii, S.; Taguchi, K.

10.1101/2025.04.16.649212 — microbiology — Posted on 2025-04-17

2363 Mutations differentially affecting the coronavirus Mac1 ADP-ribose binding and hydrolysis activities indicate that it promotes multiple stages of the viral replication cycle

O Connor, J.; Roy, A.; Khattabi, R.; Kerr, C. M.; Schwarting, N.; Alhammad, Y. M.; Gao, P.; Zhang, X.; Deng, X.; Fehr, A. R.

10.1101/2025.04.08.647734 — microbiology — Posted on 2025-04-17

2364 Decoding of T cell immunodominance patterns by an integrated mechanistic approach

Alvaro-Benito, M.; Abualrous, E. T.; Lingel, H.; Meltendorf, S.; Holzapfel, J.; de Diego Valera, P.; Sticht, J.; Kuropka, B.; Clementi, C.; Kuppler, F.; Brunner-Weinzierl, M. C.; Freund, C.

10.1101/2024.01.10.574975 — immunology — Posted on 2025-04-17

2365 Large-scale single-cell profiling of stem cells uncovers redundant regulators of shoot development and yield trait variation

Xu, X.; Passalacqua, M.; Rice, B.; Demesa-Arevalo, E.; Kojima, M.; Takebayashi, Y.; Harris, B.; Sakakibara, H.; Gallavotti, A.; Gillis, J.; Jackson, D.

10.1101/2024.03.04.583414 — plant biology — Posted on 2025-04-17

2366 Connecting growth and yield models to continuous forest inventory data to better account for uncertainty

Itter, M. S.; Finley, A. O.; Weiskittel, A.

10.1101/2025.03.14.643281 — ecology — Posted on 2025-04-17

2367 Cell type mapping of mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy using single-nucleus multiomics

Galvao, I. C.; Lemoine, M.; Kandratavicius, L.; Yasuda, C. L.; Alvim, M. K. M.; Ghizoni, E.; Blümcke, I.; Cendes, F.; Rogerio, F.; Lopes-Cendes, I.; Veiga, D. T.

10.1101/2024.12.12.628140 — neuroscience — Posted on 2025-04-17

2368 Astrocytic modulation of population encoding in mouse visual cortex via GABA transporter 3 revealed by multiplexed CRISPR/Cas9 gene editing

Park, J.; Sipe, G. O.; Tang, X.; Ojha, P.; Fernandes, G.; Leow, Y. N.; Zhang, C.; Osako, Y.; Natesan, A.; Drummond, G. T.; Jaenisch, R.; Sur, M.

10.1101/2024.11.06.622321 — neuroscience — Posted on 2025-04-17

2369 Mechanistic modeling of cell viability assays with in silico lineage tracing

Mutsuddy, A.; Huggins, J. R.; Amrit, A.; Harley-Gasaway, A. M.; Erdem, C.; Calhoun, J. C.; Birtwistle, M. R.

10.1101/2024.08.23.609433 — systems biology — Posted on 2025-04-17

2370 The general version of Hamilton's rule

van Veelen, M.

10.1101/2024.11.25.625193 — evolutionary biology — Posted on 2025-04-17

2371 Universal protocol to separate and compare Extracellular Vesicles from human plasma and skeletal muscle biopsy

Mangolini, V.; Radeghieri, A.; Piva, S.; Cattaneo, S.; Brucale, M.; Valle, F.; Balestri, A.; Montis, C.; Latronico, N.; Bergese, P.; Paolini, L.

10.1101/2024.02.19.580950 — cell biology — Posted on 2025-04-17

2372 ATG2A engages Rab1a and ARFGAP1 positive membranes during autophagosome biogenesis

Fuller, D. M.; Wu, Y.; Schueder, F.; Rasool, B.; Nag, S.; Korfhage, J. L.; Garcia-Milian, R.; Melnyk, K. D.; Bewersdorf, J.; De Camilli, P.; Melia, T.

10.1101/2025.03.24.645038 — cell biology — Posted on 2025-04-17

2373 Characterization of DNA methylation in PBMCs and donor-matched iPSCs shows methylation is reset during stem cell reprogramming

Reed, X.; Weller, C. A.; Saez-Atienzar, S.; Beilina, A.; Solaiman, S.; Portley, M.; Kaileh, M.; Roy, R.; Ding, J.; Moore, A. Z.; Whitaker, D. T.; Traynor, B. J.; Gibbs, J. R.; Scholz, S. W.; Cookson, M. R.

10.1101/2024.12.13.627515 — molecular biology — Posted on 2025-04-17

2374 Retroviral adapters hijack the RNA helicase UPF1 in a CRM1/XPO1 dependent manner and reveal proviral roles of UPF1.

Prochasson, L.; Mghezzi-Habellah, M.; Roisin, A.; Palma, M.; Robin, J.-P.; de Bossoreille, S.; Cluet, D.; Mouehli, M.; Decimo, D.; Desrames, A.; Chaze, T.; Matondo, M.; Dutartre, H.; Thoulouze, M.-I.; Lejeune, F.; Jalinot, P.; Rety, S.; Mocquet, V.

10.1101/2023.06.20.545693 — molecular biology — Posted on 2025-04-17

2375 State modulation in spatial networks with three interneuron subtypes

Edwards, M. M.; Rubin, J.; Huang, C.

10.1101/2024.08.23.609417 — neuroscience — Posted on 2025-04-17

2376 On a roll: Recent familiarity primes the brain to retrieve other memories via dopaminergic nuclei mechanisms

Dougherty, M.; Patil, A.; Duncan, K. D.

10.1101/2025.03.28.646007 — neuroscience — Posted on 2025-04-17

2377 ATF2 phosphorylation is a core transcriptional driver of neuron apoptosis

Gomez Deza, J.; Nebiyou, M.; El Touny, L. H.; Alkaslasi, M. R.; Zuo, Z.; Wlaschin, J. J.; Nadal-Nicolas, F. M.; Slavutsky, A. L.; Lloyd, E. Y.; Hayashi, P. M.; Ashby, N.; Sohn, M.; Li, W.; Cheng, K.; Rocha, P.; Le Pichon, C. E.

10.1101/2023.09.27.559856 — neuroscience — Posted on 2025-04-17

2378 Population Transcriptome and Phenotype Reveal that Rht-D1b Contributes a Larger Seedling Root to Modern Bread Wheat

Wang, X.; Zhao, P.; Shi, X.; Guo, X.; Liu, Y.; Hou, W.; Cheng, M.; Liu, X.; Lai, X.; Simmonds, J.; Harwood, W.; Wang, J.; Liu, Z.; Huang, L.; Han, D.; Ji, W.; Uauy, C.; Xiao, J.; Kang, Z.; Xu, S.

10.1101/2022.06.02.494553 — plant biology — Posted on 2025-04-17

2379 Expanding the Orchidaceae Virome Through Analysis of Public-Domain Sequencing Data

Perez, A.; Sanchez-Yali, J.; Higuita, M.; Ortiz-Reyes, A.; Gutierrez, P. A.

10.1101/2025.04.09.647952 — bioinformatics — Posted on 2025-04-17

2380 GPCRchimeraDB: A database of chimeric G protein-coupled receptors (GPCRs) to assist their design

Crauwels, C.; Diaz, A.; Vranken, W. F.

10.1101/2024.12.16.628733 — bioengineering — Posted on 2025-04-17

2381 RNA condensates as platforms for prebiotic chemistry

Hauf, S.; Nakamura, R.; Cellini, B.; Yokobayashi, Y.; Dindo, M.

10.1101/2025.04.15.648868 — biochemistry — Posted on 2025-04-17

2382 High levels of mitotic gene conversion are needed to effectively purge deleterious mutations in asexual organisms

Kopcak, D.; Hartfield, M.

10.1101/2024.08.30.610445 — evolutionary biology — Posted on 2025-04-17

2383 Multi-omics profiling of cross-resistance between ceftazidime-avibactam and meropenem identifies common and strain-specific mechanisms in Pseudomonas aeruginosa clinical isolates

Bartmanski, B. J.; Boesch, A.; Schmitt, S.; Ireddy, N.; Ren, Q.; Findlay, J.; Egli, A.; Zimmermann-Kogadeeva, M.; Babouee Flury, B.

10.1101/2025.01.14.632673 — microbiology — Posted on 2025-04-17

2384 Behavioural and neurogenetic evidence for emotion primitives in the fruit fly Drosophila

Lueningschroer-Wang, Y.; Derksen, E.; Steigmeier, M.; Wegener, C.

10.1101/2025.02.28.640745 — neuroscience — Posted on 2025-04-17

2385 Functional connectivity reveals increased network segregation and sensorimotor processing during working memory in adolescents with Neurofibromatosis Type 1

Litwinczuk, M. C.; Trujillo-Barreto, N.; Jung, J.; Garg, S.; Lea-Carnall, C. A.

10.1101/2025.04.10.648210 — neuroscience — Posted on 2025-04-17

2386 Modeling neuron-astrocyte interactions in neural networks using distributed simulation

Jiang, H.-J.; Acimovic, J.; Manninen, T.; Ahokainen, I.; Stapmanns, J.; Lehtimäki, M.; Diesmann, M.; van Albada, S. J.; Plesser, H. E.; Linne, M.-L.

10.1101/2024.11.11.622953 — neuroscience — Posted on 2025-04-17

2387 Gut Microbe-Derived N-Acyl Serinol Lipids Shape Host Postprandial Metabolic Homeostasis

Dutta, S.; Mahen, K. K.; Massey, W. J.; Varadharajan, V.; Burrows, A.; Horak, A. J.; Mrdjen, M.; Mouannes, N.; Orabi, D.; Osborn, L.; Grubb, T.; Hohe, R.; Banerjee, R.; Uppin, V.; Laungani, D.; Hamilton, G.; Ye, X.; Sangwan, N.; Dwidar, M.; Hajjar, A.; Willard, B.; Martin, M.; Guetschow, E.; Westcott, P.; Wang, Z.; Hazen, S. L.; Brown, J. M.

10.1101/2025.04.11.648385 — physiology — Posted on 2025-04-17

2388 TWIST1 mediated transcriptional activation of SPON2 drives colorectal peritoneal metastasis through activation of cancer-associated fibroblast signaling network

Zhou, Z.; La Ferlita, A.; Palavalli, M.; Chen, X. F.; Tyler, L.; Ejaz, A.; Beane, J.; Polanco, P.; Huang, H.; Kim, A. C.

10.1101/2025.04.11.648429 — cancer biology — Posted on 2025-04-17

2389 panomiX: Investigating Mechanisms Of Trait Emergence Through Multi-Omics Data Integration

Sahu, A.; Psaroudakis, D.; Rolletschek, H.; Neumann, K.; Borisjuk, L.; Himmelbach, A.; Pinninti, K.; Töpfer, N.; Szymanski, J. J.

10.1101/2025.04.11.648356 — bioinformatics — Posted on 2025-04-17

2390 Sex- and estrous-specific effects of paradoxical (REM) sleep deprivation: Neurobehavioral changes and hippocampal neuroinflammation

Olsen, L. K.; Jones, K. A.; Moore, R. J.; McCubbins, H. C.; Curtner, F. S.; Sharma, B.; Hatcher-Solis, C. N.

10.1101/2025.04.11.648374 — animal behavior and cognition — Posted on 2025-04-17

2391 Seasonal brain regeneration and chromosome instability are linked to selection on DNA repair in Sorex araneus

Thomas, W. R.; Lama, T. M.; Moreno-Santillan, D.; Farre, M.; Baldoni, C.; Abueg, L.; Balacco, J.; Fedrigo, O.; Formenti, G.; Jain, N.; Mountcastle, J.; Tilley, T.; Tracey, A.; Ray, D. A.; Dechmann, D. K. N.; von Elverfeldt, D.; Nieland, J.; Corthals, A. P.; Jarvis, E.; Davalos, L. M.

10.1101/2025.04.11.648246 — evolutionary biology — Posted on 2025-04-17

2392 Bark beetles as ecosystem engineers: triggered tree mortality rearranges the assemblage of Tree-related Microhabitats in old-growth coniferous forest

Przepiora, F.; Ciach, M.

10.1101/2025.04.11.648382 — ecology — Posted on 2025-04-17

2393 Spatially organized cellular communities shape functional tissue architecture in the pancreas

Torres-Cano, A.; Darrigrand, J.-F.; Herrera-Oropeza, G.; Goss, G.; Willnow, D.; Salowka, A.; Chitnis, D.; Rouault, M.; Vigilante, A.; Spagnoli, F. M.

10.1101/2025.04.16.649169 — developmental biology — Posted on 2025-04-17

2394 C9orf72 ALS-causing mutations lead to nucleoporin Nup107 aggregation and subsequent pathological changes

Vilchez, D.; Bilican, S.; Nabawi, Y.; Zhang, W. H.

10.1101/2025.04.16.649118 — cell biology — Posted on 2025-04-17

2395 A putative bacterial ecocline in Klebsiella pneumoniae

Liu, S.; Svensson, S. L.; Falush, D.

10.1101/2025.01.20.633859 — microbiology — Posted on 2025-04-17

2396 Neutrophils matter: New clinical insights on their role in the progression of metastatic breast cancer

Correia, B. F.; Grosa, D.; Salvador, R.; Brites, I.; Martins, T.; Vitorino, M.; Sousa, C. X.; Cristovao-Ferreira, S.; Braga, S.; Jacinto, A.; Cabral, M. G.

10.1101/2025.04.11.648384 — immunology — Posted on 2025-04-17

2397 Intrinsic and circuit mechanisms of predictive coding in a grid cell network model

Shaikh, I.; Assisi, C.

10.1101/2025.04.11.648301 — neuroscience — Posted on 2025-04-17

2398 Weakened prefrontal activation dynamics associated with slowed information processing speed in multiple sclerosis

Burta, O.; Akbarian, F.; Rossi, C.; Vidaurre, D.; d'Hooghe, M. B.; D'Haeseleer, M.; Nagels, G.; Van Schependom, J.

10.1101/2025.04.08.647709 — neuroscience — Posted on 2025-04-17

2399 Impairment of the blood brain barrier accelerates a negative ultraslow potential in the locust CNS

Robertson, M.; Donini, A.; wang, y.

10.1101/2025.04.11.648410 — neuroscience — Posted on 2025-04-17

2400 Alzheimer's disease and its co-pathologies: implications for hippocampal degeneration, cognitive decline, and the role of APOE ϵ4

Gawor, K.; Verrept, S.; Arekatla, G.; Wouters, D.; Ronisz, A.; Hecht, M.; Laureyssen, C.; Ver Donck, H.; Lahaije, B.; Ospitalieri, S.; Vandenbulcke, M.; Otto, M.; von Arnim, C. A. F.; Ghebremedhin, E.; Hanseeuw, B.; Vandenberghe, R.; Blaschko, M.; Sifrim, A.; Sleegers, K.; Thal, D. R.; Tome, S. O.

10.1101/2025.04.11.648343 — neuroscience — Posted on 2025-04-17

2401 Predicting RNA 3D structure and conformers using a pre-trained secondary structure model and structure-aware attention

Wang, W.; Peng, Z.; Yang, J.

10.1101/2025.04.09.647915 — bioinformatics — Posted on 2025-04-17

2402 A structural basis for chaperone repression of stress signalling from the endoplasmic reticulum

Neidhardt, L.; Tung, J.; Kuchersky, M.; Milczarek, J.; Kargas, V.; Stott, K.; Rosenzweig, R.; Ron, D.; Yan, Y.

10.1101/2025.04.14.648677 — biochemistry — Posted on 2025-04-17

2403 Identification of Multi-landscape and Cell Interactions in the Tumor Microenvironment through High-Coverage Single-Cell Sequencing

Zhong, W.; Wang, L.; Zhang, C.; Guo, T.; zhao, l.; Wu, D.; Xie, F.; Wang, X.; Li, X.; Wang, F.; Li, M.; Gu, W.; Lin, T.; Chen, X.

10.1101/2024.06.18.599463 — genomics — Posted on 2025-04-17

2404 G protein-coupled receptor diversity and evolution in the closest living relatives of Metazoa

Garcia De Las Bayonas, A.; King, N.

10.1101/2025.04.15.649019 — evolutionary biology — Posted on 2025-04-17

2405 Standardized and calibrated light stimuli via head-mounted displays for investigating the non-visual effects of light

Fernandez Alonso, M.; Spitschan, M.

10.1101/2025.01.15.633125 — neuroscience — Posted on 2025-04-17

2406 Dissociable dynamic effects of expectation during statistical learning.

McDermott, H. H.; De Martino, F.; Schwiedrzik, C. M.; Auksztulewicz, R.

10.1101/2024.09.05.611380 — neuroscience — Posted on 2025-04-17

2407 Functional Specialization for Language Processing in Inferior Frontal Regions During Early Childhood: Evidence from functional near-infrared spectroscopy individual functional channels of interest approach

LUO, H.; YU, T.; LI, Q.; SHENG, L.

10.1101/2025.02.09.637301 — neuroscience — Posted on 2025-04-17

2408 Intestinal Tissue Mechanics Regulate Angiogenesis and Stem Cell Proliferation via Vascular Piezo

Phillips, J. A.; Perochon, J.; Johnson, C. T.; Walker, M.; Nixon, C.; Hughes, M.; Barros Carvalho, A.; Yu, Y.; Mitchell, L.; Blyth, K.; Vassalli, M.; Cordero, J. B.

10.1101/2025.04.16.649133 — developmental biology — Posted on 2025-04-17

2409 Frontal oscillatory beta bursts have rhythmically distinct regimes with differing functional relevance

Langford, Z. D.; Procyk, E.; Wilson, C. R.

10.1101/2023.11.13.566594 — neuroscience — Posted on 2025-04-17

2410 Multimetric MRI Captures Early Response and Acquired Resistance of Pancreatic Cancer to KRAS Inhibitor Therapy

Gupta, M.; Choi, H.; Kemp, S.; Furth, E. E.; Pickup, S.; Clendenin, C.; Orlen, M.; Rosen, M.; Liu, F.; Cao, Q.; Stanger, B.; Zhou, R.

10.1101/2024.11.22.624844 — cancer biology — Posted on 2025-04-17

2411 AF2χ: Predicting protein side-chain rotamer distributions with AlphaFold2

Cagiada, M.; Thomasen, F. E.; Ovchinnikov, S.; Deane, C.; Lindorff-Larsen, K.

10.1101/2025.04.16.649219 — biophysics — Posted on 2025-04-17

2412 Assessing scoring metrics for AlphaFold2 and AlphaFold3 protein complex predictions

Genz, L. R.; Nair, S.; Topf, M.

10.1101/2025.04.16.648930 — bioinformatics — Posted on 2025-04-17

2413 Dual-Field Microvascular Segmentation: Hemodynamically- Consistent Attention Learning for Retinal Vasculature Mapping

Zhang, J.; Liu, X.; Zheng, S.; Zhang, W.; Gu, J.

10.1101/2024.11.27.625635 — bioinformatics — Posted on 2025-04-17

2414 Assess the quality of different transcriptomic small RNA alignment techniques by analyzing multiple sources of variability using a multi-alignment framework.

Zhao, X.; Korsching, E.

10.1101/2025.02.18.638849 — bioinformatics — Posted on 2025-04-17

2415 Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein

Shinkai, Y.; Ding, Y.; Matsui, T.; Devitt, G.; Akiyama, M.; Shen, T.-L.; Nishida, M.; Ida, T.; Akaike, T.; Mahajan, S.; Fukuto, J. M.; Shigeta, Y.; Kumagai, Y.

10.1101/2023.10.19.563042 — biochemistry — Posted on 2025-04-17

2416 Structural Visualization of HECT-type E3 ligase Ufd4 Accepting and Transferring Ubiquitin to Form K29/K48-branched Polyubiquitination

Wu, X.; Ai, H.; Mao, J.; Cai, H.; Liang, L.; Tong, Z.; Zheng, Q.; LIU, L.; Pan, M.

10.1101/2023.05.23.542033 — biochemistry — Posted on 2025-04-17

2417 Optimized Phylogenetic Eigenvector Regression Provides Robust and Flexible Trait Correlation Analysis under Diverse Evolutionary Conditions

Chen, Z.-L.; Niu, D.-K.

10.1101/2024.04.14.589420 — evolutionary biology — Posted on 2025-04-17

2418 Mutation bias alters the distribution of fitness effects of mutations

Sane, M.; Parveen, S.; Agashe, D.

10.1101/2024.03.24.586369 — evolutionary biology — Posted on 2025-04-17

2419 Parvovirus infection affects host cell nucleolar organization and ribosome biogenesis

Huttunen, M.; Hakanen, S.; Aho, V.; Leclerc, S.; Soenmez, A.; Kapishnikov, S.; Zannotti, A.; Ruokolainen, V.; Salokas, K.; Varjosalo, M.; Latonen, L.; Parrish, C. R.; Fahy, K.; Mattola, S.; Lafontaine, D. L.; Vihinen-Ranta, M.

10.1101/2022.06.07.495090 — cell biology — Posted on 2025-04-17

2420 Glycosylated IgG antibodies accelerated the recovery of haemorrhagic fever with renal syndrome patients

Quan, C.; Wang, L.; Gao, J.; Li, Y.; Xu, X.; Li, H.; Gao, Z.; Ruan, W.; Liu, H.; Li, Q.; Xing, W.; Zhao, L.; Carr, M. J.; Shi, W.; Hou, H.

10.1101/2025.04.11.648365 — immunology — Posted on 2025-04-17

2421 Hippocampus facilitates reinforcement learning under partial observability

Pedamonti, D.; Mohinta, S.; Dimitrov, M.; Malagon-Vina, H.; Ciocchi, S.; Costa, R. P.

10.1101/2023.11.09.565503 — neuroscience — Posted on 2025-04-17

2422 TS2CG as a membrane builder

Schuhmann, F.; Stevens, J. A.; Rahmani, N.; Lindahl, I.; Brown, C. M.; Brasnett, C.; Anastasiou, D.; Bravo Vidal, A.; Geiger, B. J.; Marrink, S.-J.; Pezeshkian, W.

10.1101/2025.04.16.649160 — biophysics — Posted on 2025-04-17

2423 Coarse-Grained RNA Model for the Martini 3 Force Field

Yangaliev, D.; Ozkan, S. B.

10.1101/2025.04.13.648640 — biophysics — Posted on 2025-04-17

2424 Structural basis of apoptosis induction by the mitochondrial voltage dependent anion channel

Daniilidis, M.; Guensel, U.; Broutzakis, G.; Janowski, R.; Leitl, K.; Fredriksson, K.; Niessing, D.; Gatsogiannis, C.; Hagn, F. X.

10.1101/2025.04.15.648943 — biophysics — Posted on 2025-04-17

2425 Scaling Large Language Models for Next-Generation Single-Cell Analysis

Rizvi, S. A.; Levine, D.; Patel, A.; Zhang, S.; Wang, E.; He, S.; Zhang, D.; Tang, C.; Lyu, Z.; Darji, R.; Li, M.; Sun, E.; Jeong, D.; Zhao, L.; Kwan, J.; Braun, D.; Hafler, B.; Ishizuka, J.; Dhodapkar, R.; Chung, H.; Azizi, S.; Perozzi, B.; van Dijk, D.

10.1101/2025.04.14.648850 — bioinformatics — Posted on 2025-04-17

2426 Genomic studies in Linum shed light on the evolution of the distyly supergene and the molecular basis of convergent floral evolution

Zervakis, P.-I.; Postel, Z.; Losvik, A.; Fracassetti, M.; Soler, L.; Proux-Wera, E.; Bunikis, I.; Churcher, A.; Slotte, T.

10.1101/2025.04.11.648331 — evolutionary biology — Posted on 2025-04-17

2427 Brain precapillary sphincters modulate myogenic tone in adult and aged mice

Fjorbak, C.; Kutuzov, N.; Groves, T.; Lauritzen, M.; Grubb, S.

10.1101/2025.04.11.648315 — neuroscience — Posted on 2025-04-17

2428 Anti-Aβ immunotherapy-mediated amyloid clearance attenuates microglial activation without inducing exhaustion at residual plaques

de Weerd, L.; Hummel, S.; Mueller, S. A.; Paris, I.; Sandmann, T.; Eichholtz, M.; Gröger, R.; Englert, A.; Wagner, S.; Ha, C.; Davis, S. S.; Warkins, V.; Xia, D.; Nuscher, B.; Berghofer, A.; Reich, M.; Feiten, A. F.; Schlepckow, K.; Willem, M.; Lichtenthaler, S. F.; Lewcock, J. W.; Monroe, K. M.; Brendel, M.; Haass, C.

10.1101/2025.04.10.645950 — neuroscience — Posted on 2025-04-17

2429 Optimal inter-electrode distances for maximizing single unit yield per electrode in neural recordings

Meszena, D.; Fadel, W.; Toth, R.; Paulk, A. C.; Cash, S. S.; Williams, Z.; Kiss, T.; Stippinger, M.; Wittner, L.; Fiath, R.; Somogyvari, Z.

10.1101/2025.04.11.648355 — neuroscience — Posted on 2025-04-17

2430 Pseudo-time trajectory of single-cell lipidomics: Suggestion for experimental setup and computational analysis

Jost, P. J.; Weindl, D.; Wunderling, K.; Thiele, C.; Hasenauer, J.

10.1101/2025.04.11.648323 — systems biology — Posted on 2025-04-17

2431 Small things matter: Lack of extra-islet beta cells in Type 1 diabetes

Murrall, K.; Luckett, T.; Lekka, C.; Flaxman, C. S.; Wyatt, R.; Akhbari, P.; Kusmartseva, I.; Hunter, S. L.; Leete, P.; Burn, I.; Osokina, E.; EXE-T1D Consortium, ; Shaw, J. A. M.; Morgan, N. G.; Richardson, S. J.

10.1101/2025.04.11.648319 — pathology — Posted on 2025-04-17

2432 Can interpretability and accuracy coexist in cancer survival analysis?

Borole, P.; Wang, T.; Vergari, A.; Rajan, A.

10.1101/2025.04.11.648380 — bioinformatics — Posted on 2025-04-17

2433 CellFlow enables generative single-cell phenotype modeling with flow matching

Klein, D.; Fleck, J. S.; Bobrovskiy, D.; Zimmermann, L.; Becker, S.; Palma, A.; Dony, L.; Tejada-Lapuerta, A.; Huguet, G.; Lin, H.-C.; Azbukina, N.; Sanchis-Calleja, F.; Uscidda, T.; Szalata, A.; Gander, M.; Regev, A.; Treutlein, B.; Camp, J. G.; Theis, F. J.

10.1101/2025.04.11.648220 — bioinformatics — Posted on 2025-04-17

2434 Global and cross-omics feature aggregation improves single-cell multi-omics integration and clustering

guo, y.; chenyang, c.; zhu, z.; zhou, j.; Lu, H.; qian, y.; Liang, Z.

10.1101/2025.04.10.648152 — bioinformatics — Posted on 2025-04-17

2435 Leveraging agent-based models and deep reinforcement learning to predict taxis in cell migration: Insights from barotaxis

Camacho-Gomez, D.; Sentiero, R.; Ventre, M.; Garcia-Aznar, J. M.

10.1101/2025.04.11.648312 — bioengineering — Posted on 2025-04-17

2436 Chemosensitive brainstem and diencephalic components in breath-hold fMRI

Cauzzo, S.; Callara, A. L.; Morelli, M. S.; Hartwig, V.; Sozzi, S.; Frijia, F.; Esposito, F.; Bianciardi, M.; Montanaro, D.; Passino, C.; Emdin, M.; Giannoni, A.; Vanello, N.

10.1101/2025.04.11.648311 — bioengineering — Posted on 2025-04-17

2437 PETScan: Score-Based Genome-Wide Association Analysis of RNA-Seq and ATAC-Seq Data

Hao, Y.; Kafri, T.; Zou, F.

10.1101/2025.04.10.648278 — genomics — Posted on 2025-04-17

2438 Biologically-informed Interpretable Deep Learning Framework for Phenotype Prediction and Gene Interaction Detection

Hequet, C. C.; Gaggiotti, O.; Parachini, S.; Bochukova, E.; Ye, J.

10.1101/2025.04.11.648325 — genomics — Posted on 2025-04-17

2439 Genome-wide differentiation and SNP-based identification of northeastern Atlantic Sebastes species

Jansson, E.; Besnier, F.; Christiansen, H.; Saha, A.; Tranang, C. A.; Bruvold, I. M.; Mateos Rivera, A.; Johansen, T.

10.1101/2025.04.11.648347 — genetics — Posted on 2025-04-17

2440 Predicting kinship dynamics during pre- and post reproductive life stages

He, P.; Weiss, M. N.; Ellis, S.; Franks, D. W.; Cant, M. A.; Croft, D. P.; Johnstone, R. A.

10.1101/2025.04.11.648073 — evolutionary biology — Posted on 2025-04-17

2441 Abnormal Tau Protein Influences Intercellular Mitochondrial Transfer Between Astrocytic and Neuronal Cells

RIOU, A.; Broeglin, A.; Papassotiropoulos, A.; Eckert, A.; Grimm, A.

10.1101/2025.04.11.648113 — neuroscience — Posted on 2025-04-17

2442 RNAcompare: Integrating machine learning algorithms to unveil the similarities of phenotypes based on clinical, multi-omics using Rheumatoid Arthritis and Heart Failure as Case Studies

Tang, M.

10.1101/2025.04.02.646760 — bioinformatics — Posted on 2025-04-17

2443 Fronto-parietal effective connectivity during working memory in Neurofibromatosis Type 1 adolescents and neurotypical controls

Litwinczuk, M. C.; Garg, S.; Green, J.; Lea-Carnall, C. A.; Trujillo-Barreto, N.

10.1101/2025.04.10.648183 — neuroscience — Posted on 2025-04-17

2444 A community-consensus reconstruction of Chinese Hamster metabolism enables structural systems biology analyses to decipher metabolic rewiring in lactate-free CHO cells

Di Giusto, P.; Choi, D.-H.; Antonakoudis, A.; Duraikannan, V. G.; Craveur, P.; Cowie, N. L.; Ganapathy, T.; Ramesh, K.; Benavidez-Lopez, S.; Orellana, C. A.; Jimenez, N. E.; Dworkin, L. A.; Morrissey, J.; Marin de Mas, I.; Strain, B.; Valdez-Cruz, N. A.; Trujillo-Roldan, M. A.; Marzluf, J.; Martinez, V. S.; Zehetner, L.; Altamirano, C.; Vega-Letter, A. M.; Priem, B.; Cao, H. C.; Hold, M.; Ma, J.; Hong, Y.; Gopalakrishnan, S.; Enuh, B. M.; Tarzi, C.; Pang, K. T.; Angione, C.; Zanghellini, J.; Kontoravdi, C.; Hefzi, H.; Betenbaugh, M. J.; Nielsen, L. K.; Lakshmanan, M.; Lee, D.-Y.; Richelle, A.;

10.1101/2025.04.10.647063 — systems biology — Posted on 2025-04-17

2445 A longitudinal evaluation of localised chronic Pseudomonas aeruginosa infection in cystic fibrosis rat models

Reyne, N.; Boog, B.; Cmielewski, P.; McCarron, A.; Smith, R.; Rout-Pitt, N.; Eikelis, N.; Nilsen, K.; Finnie, J.; Louise, J.; Parsons, D.; Donnelley, M.

10.1101/2025.04.11.647899 — pathology — Posted on 2025-04-17

2446 NSUN2 drives intestinal stem cell expansion and colorectal tumour initiation via MAPK/ERK signalling

Bastem Akan, A.; Billard, C. V.; Chen, S.-Y.; Huang, P.-H.; Cammareri, P.; Hall, A. E.; Preyzner, P.; Din, F. V. N.; Myant, K. B.

10.1101/2025.04.11.648351 — cancer biology — Posted on 2025-04-17

2447 Pan-Cancer PDOs Preserve Tumor Heterogeneity and Uncover Therapeutic Vulnerabilities

Kuo, H.-H.; Bhinder, B.; Gokozan, H. N.; Gorski, K.; Chandra, P.; Manohar, J.; Guevara, D.; Otilano, J.; Moyer, J.; Tranquille, M.; Ackermann, S.; Capuano, J.; Cheung, C.; Caiazza, T. A.; Reuben, P. L.; Irizarry, A.; Tsomides, A. M.; Sigouros, M.; Wilkes, D.; King, A.; Kane, T.; Al Assaad, M.; Al Zoughbi, W.; Ohara, K.; Auh, J.; Waltman, P.; Madorsky Rowdo, F. P.; Podaza, E.; Gallegos, V.; Nguyen, J.; Shah, R.; Shah, M.; Ocean, A.; Scherr, D.; Altorki, N.; Frey, M.; Molina, A. M.; Newman, L.; Bea, V.; Chapman-Davis, E.; Goncalves, M. D.; Saxena, A.; Shukla, P. J.; Holcomb, K.; Simmons, R.; Tag

10.1101/2025.04.10.647635 — cancer biology — Posted on 2025-04-17

2448 Large Language Model Consensus Substantially Improves the Cell Type Annotation Accuracy for scRNA-seq Data

Yang, C.; Zhang, X.; Chen, J.

10.1101/2025.04.10.647852 — bioinformatics — Posted on 2025-04-17

2449 BRIDGE: A Coarse-Grained Architecture to Embed Protein-Protein Interactions for Therapeutic Applications

Khade, P. M.; Watkins, A. M.

10.1101/2025.04.11.648307 — bioinformatics — Posted on 2025-04-17

2450 GeST: Towards Building A Generative Pretrained Transformer for Learning Cellular Spatial Context

Hao, M.; Yan, N.; Bian, H.; Chen, Y.; Gu, J.; Wei, L.; Zhang, X.

10.1101/2025.04.09.648072 — bioinformatics — Posted on 2025-04-17

2451 Screening analysis of light-responsive phenotype of leaf bacteria

Iguchi, H.; Kanagasaki, M.; Ishii, S.; Taguchi, K.

10.1101/2025.04.16.649212 — microbiology — Posted on 2025-04-16

2452 An integrative taxonomic approach reveals unexplored diversity in Croatian planarians

Vila-Farre, M.; Brand, J. N.; Boothe, T.; Brockmeyer, M.; Ficze-Schmidt, F.; Grohme, M. A.; Weill, U.; Kluiver, K. H.; Gasiorowski, L.; Kauf, L.; Kanana, Y.; Bilandzija, H.; Riutort, M.; Rink, J. C.

10.1101/2025.04.10.648211 — zoology — Posted on 2025-04-16

2453 PMI estimation on aqueous humour: human translation from a metabolomic animal model.

Chighine, A.; Stocchero, M.; De-Giorgio, F.; Nioi, M.; d'Aloja, E.; Locci, E.

10.1101/2025.04.15.648907 — systems biology — Posted on 2025-04-17

2454 STM is required for fate establishment of productive shoot progenitor cells in Arabidopsis tissue culture

Zhai, N.; Xie, D.; Xu, L.

10.1101/2025.04.14.648630 — plant biology — Posted on 2025-04-17

2455 Detection of Aggressive Mesenchymal Glioblastoma by Mannose-Weighted CEST MRI

Ghaemi, B.; Lopez-Bertoni, H.; Kuddannaya, S.; Sall, S.; Laterra, J.; Liu, G.; Bulte, J.

10.1101/2025.04.15.648948 — cancer biology — Posted on 2025-04-17

2456 Targeting protein glycosylation and cholesterol metabolism in chemoresistant pancreatic cancer

Li, Y.; Tang, S.; Wang, H.; Zhu, H.; Guo, S.; Zhang, Y.; Lu, Y.; Sun, M.; He, J.; Li, Y.; Zhang, Y.; Shi, X.; Miao, Y.; Zhong, C.; Zhu, Y.; Ju, Y.; Liu, Y.; Wang, Y.; Chen, L.; Zhou, H.; Jin, G.; Gao, D.

10.1101/2025.04.13.648567 — cancer biology — Posted on 2025-04-17

2457 Learning and predicting fishing activities from AIS data

Johannsen, K.; Tai, X.-C.; Fonnes, G.; You, J.

10.1101/2025.04.11.648363 — biophysics — Posted on 2025-04-17

2458 Invasive cancer cells soften collagen networks and disrupt stress-stiffening via volume exclusion, contractility and adhesion

Nagle, I.; Tavasso, M.; Bordoloi, A. D.; Muntz, I. A. A.; Koenderink, G. H.; Boukany, P. E.

10.1101/2025.04.11.648338 — biophysics — Posted on 2025-04-17

2459 Phase Separation and a Hydrodynamic Instability Localize Proteins at Growing Microtubule Ends

Schaer, J.; Miesch, J.; Catapano, V.; Dumoulin, L.; Tran, J.; Velluz, M.-C.; Aumeier, C.; Kruse, K.

10.1101/2025.04.11.648094 — biophysics — Posted on 2025-04-17

2460 From Molecular Insight to Mesoscale MembraneRemodeling: Curvature Generation byArginine-Rich Cell-Penetrating Peptides

Baxova, K. L.; Koikkara, J.; Allolio, C.

10.1101/2025.04.14.648709 — biophysics — Posted on 2025-04-17

2461 Nanobodies as therapies for loss-of-function misfolding diseases.

Mulas, A. G.; Dindo, M.; Pacheco, J. L.; Grotelli, S.; Cano, M.; Vankova, P.; Loginov, D.; Salido, E.; Man, P.; Conejero-Lara, F.; Cellini, B.; Pey, A. l.

10.1101/2025.04.12.648492 — biophysics — Posted on 2025-04-17

2462 Interactions between the picornavirus 3C(D) main protease and RNA induce liquid-liquid phase separation

Mondal, S.; Mukherjee, S.; Namitz, K. E. W.; Yennawar, N.; Boehr, D. D.

10.1101/2025.04.14.648818 — biophysics — Posted on 2025-04-17

2463 Characterization of PROTACs by Ternary Complex Landscape Exploration using Monte Carlo simulations

Diaz-Rovira, A. M.; Perez-Lopez, C.; Martin-Perez, J.; Pallara, C.; Diaz, L.; Guallar, V.

10.1101/2025.04.11.648328 — biophysics — Posted on 2025-04-17

2464 Client-scaffold interactions suppress aggregation of a client protein in model condensates

Ahmed, R.; Hudson, R. P.; Forman-Kay, J. D.; Kay, L. E.

10.1101/2025.04.11.648422 — biophysics — Posted on 2025-04-17

2465 Measuring the selective packaging of RNA molecules by viral coat proteins in cells

Rastandeh, A.; Makasarashvili, N.; Dhaliwal, H. K.; Subramanian, S.; Villarreal, D. A.; Baker, S.; Gamez, E. I.; Parent, K. N.; Garmann, R. F.

10.1101/2025.04.14.648219 — biophysics — Posted on 2025-04-17

2466 NMR and molecular dynamics demonstrate the RNA internal loop GAGU is dynamic and adjacent base pairs determine conformational preference

Akinyemi, O.; Kennedy, S. D.; McSally, J. P.; Mathews, D. H.

10.1101/2025.04.14.648754 — biophysics — Posted on 2025-04-17

2467 Gliomas organize as liquid crystals: three-dimensional nematic order, disclinations and quasi-long-range order

Argento, A. E.; Varela, M. L.; Singh, G.; Visnuk, D. P.; Jacobovitz, B.; Rutherford, M. E.; Edwards, M. B.; Chaboche, Q.; Orringer, D. A.; Heth, J. A.; Castro, M. G.; Beller, D. A.; Blanch-Mercader, C.; Lowenstein, P.

10.1101/2025.04.14.648711 — biophysics — Posted on 2025-04-17

2468 Expression and In-silico Structural analysis of N-acetylglucosamine transporter, Ngt1 in model fungal pathogen, Candida albicans

Haseena, S.; Goud, N. N.; Paul, S.; Ghosh, S.; Rao, K. H.; Sharma, S.

10.1101/2025.04.14.648653 — bioinformatics — Posted on 2025-04-17

2469 Glycoengineering of nematode antigens using insect cells: a promising approach for producing bioactive vaccine antigens of the barber's pole worm Haemonchus contortus

Adduci, I.; Sajovitz-Grohmann, F.; Wortha, L. N.; Dutkiewicz, Z.; Weidinger, H.; Rohrer, S. B.; Joachim, A.; Wittek, T.; Werling, D.; Wilson, I. B. H.; Lichtmannsperger, K.; Yan, S.

10.1101/2025.04.11.646772 — bioengineering — Posted on 2025-04-17

2470 Chemoenzymatic synthesis of sialylated and fucosylated mucin analogs reveals glycan-dependent effects on protein conformation and degradation.

Kramer, J. R.; Wood, A. M.; Wardzala, C. L.

10.1101/2025.04.15.648972 — bioengineering — Posted on 2025-04-17

2471 Peruvian Population Genomics: Unraveling the Genetic Landscape and Admixture Dynamics of Urban Populations

Borda, V.; Caceres, O.; Sanchez, C.; Padilla, C.; Veliz-Otani, D.; Mendes, M.; Silva-Carvalho, C.; Alvin, I.; Maron, B. A.; Gouveia, M. H.; Peruvian Genome Project Consortium, ; Tarazona-Santos, E.; Guio, H.; O'Connor, T. D.

10.1101/2025.04.10.648256 — genetics — Posted on 2025-04-16

2472 A genomic perspective on the origins, evolution and adaptation of Galapagos iguanas

Lopez-Delgado, J.; Carr, I. M.; Paradiso, C.; Gratton, P.; Colosimo, G.; van den Burg, M. P.; Debrot, A. O.; Sevilla, C. R.; Mat-Isa, M. N.; Bayliss, R.; Gerber, G. P.; Raih, M. F.; O'Connell, M. J.; Gentile, G.; Goodman, S. J.

10.1101/2025.04.13.648612 — evolutionary biology — Posted on 2025-04-17

2473 The nutritional content of anthropogenic resources affects wildlife disease dynamics

Sauer, E. L.; Hite, J. L.; DuRant, S. E.

10.1101/2025.04.10.648226 — ecology — Posted on 2025-04-16

2474 The C-terminus of the multi-drug efflux pump EmrE prevents proton leak by gating transport

Brousseau, M.; Teng, D.; Thomas, N.; Voth, G. A.; Henzler-Wildman, K. A.

10.1101/2024.11.21.624706 — biophysics — Posted on 2025-04-16

2475 Habitat use and diel activity of insectivorous bats across land-use types on an Afrotropical oceanic island

Palmeirim, A. F.; Araujo-Fernandes, A. C.; Castro-Fernandes, A. S.; Guedes, P.; Santos, Y. d.; Alves, J. C.; Mata, V. A.; Yoh, N.; Rocha, R.

10.1101/2025.04.10.648189 — ecology — Posted on 2025-04-16

2476 AI-directed voxel extraction and volume EM identify intrusions as sites of mitochondrial contact

Padman, B. S.; Lindblom, R. S. J.; Lazarou, M.

10.1101/2024.11.20.624606 — cell biology — Posted on 2025-04-16

2477 Boosting Cellular Longevity Through Intracellular ATP Modulation

Oz, N.; Su, H.; Patnaik, P.; Prosser, D.; Labunskyy, V.; Hameed, R.; Gladyshev, V. N.; Hao, N.; Kaya, A.

10.1101/2025.04.14.648769 — molecular biology — Posted on 2025-04-16

2478 Polymyxin B lethality requires energy-dependent outer membrane disruption

Borrelli, C.; Douglas, E. J. A.; Riley, S. M. A.; Lemonidi, A. E.; Larrouy-Maumus, G. B.; Lu, W.-J.; Bonev, B. B.; Edwards, A. M.; Hoogenboom, B. W.

10.1101/2025.04.16.649083 — microbiology — Posted on 2025-04-16

2479 The Salmonella phage shock protein system is required for defense against host antimicrobial peptides

Massicotte, M.-A.; Fiebig, A.; Bogza, A.; Coombes, B. K.

10.1101/2025.04.16.649068 — microbiology — Posted on 2025-04-16

2480 Viability Differentiation Improves the Diagnostic Potential of 16S rRNA Gene Sequencing in Ready-to-Eat Meat Manufacturing

Brown, J. A.; Ricke, S. C.

10.1101/2025.04.16.649186 — microbiology — Posted on 2025-04-16

2481 Contribution of UbrA, a ubiquitin ligase essential for Arg/N-degron pathway, to peptidase gene expression in Aspergillus oryzae

Muromachi, W.; Ohba, M.; Kawarasaki, Y.; Yamagata, Y.; Tanaka, M.

10.1101/2025.04.16.649092 — microbiology — Posted on 2025-04-16

2482 Characterization and evolutionary history of novel SARS-CoV-2-related viruses in bats from Cambodia

Ou, T. P.; Guillebaud, J.; Baidaliuk, A.; Tum, S.; Chheang, D.; Delaune, D.; Prot, M.; Rahal Guaragna Machado, R.; Pum, L.; Hul, V.; Hoem, T.; Ly, S.; Auerswald, H.; Smith, G. J.; Dussart, P.; Karlsson, E. A.; Chevalier, V.; Cappelle, J.; Duong, V.; Simon-Loriere, E.

10.1101/2025.04.15.648942 — microbiology — Posted on 2025-04-16

2483 Plant miRNAs and amino acids interact to shape soil bacterial communities.

Dozois, J. A.; Duchesne, M.-A.; Hallaf, K.; Tremblay, J.; Yergeau, E.

10.1101/2025.04.16.649127 — microbiology — Posted on 2025-04-16

2484 The Gut Microbiome and Butyrate Differentiate Clostridioides difficile Colonization and Infection in Children

Nicholson, M.; Ma, S.; Stricland, B. A.; Cecala, M.; Zhang, L.; Reasoner, S.; Guiberson, E.; Munneke, M.; Shilts, M. H.; Skaar, E. P.; Das, S. R.

10.1101/2025.04.16.648821 — microbiology — Posted on 2025-04-16

2485 Analysis of (p)ppGpp metabolism and signaling using a dynamic luminescent reporter

Hydorn, M.; Nagarajan, S. N.; Fones, E.; Harwood, C.; Dworkin, J.

10.1101/2025.04.16.649062 — microbiology — Posted on 2025-04-16

2486 An antibody-drug conjugate exploiting a bacterial immune evasion mechanism is effective against multidrug resistant Neisseria gonorrhoeae

Lavender, H.; Barendt, T. A.; Lucy, D.; Tang, C. M.

10.1101/2025.04.16.644158 — microbiology — Posted on 2025-04-16

2487 Phylogenetic position and mitochondrial genome evolution of 'orphan' eukaryotic lineages

Zlatogursky, V.; Boscaro, V.; Lax, G.; Wanntorp, M.; Pohl, N.; Burki, F.; Keeling, P. J.

10.1101/2025.04.16.649146 — microbiology — Posted on 2025-04-16

2488 Extracellular superoxide production is a widespread photoacclimation strategy in phytoplankton

Plummer, S.; Garcia, S.; Diaz, J. M.

10.1101/2025.04.16.649151 — microbiology — Posted on 2025-04-16

2489 Rhesus macaques model human Mayaro virus disease and transmit to Aedes aegypti mosquitoes

Moore, A. J.; Van Rompay, K. K. A.; Louie, W.; Watanabe, J. K.; An, S.; Leung, R.; Usachenko, J. L.; Chu, P. N.; Olstad, K. J.; McCoy, C. S.; Campos, R. K.; Weaver, S. C.; Rossi, S. L.; Coffey, L. L.

10.1101/2025.04.16.649064 — microbiology — Posted on 2025-04-16

2490 Coupling Anaerobic Oxic and Integrated Fixed Activated Sludge Processes for Removal and Transformation of Refractory Organic Matter in Livestock and Poultry Digestate

Li, B.; Yuan, H.; Ge, Z.

10.1101/2025.04.15.649029 — microbiology — Posted on 2025-04-16

2491 YDS-GlueFold: Surpassing AlphaFold 3-Type Models for Molecular Glue-Induced Ternary Complex Prediction

Che, X.; The Statistical Mechanics Inference Team,

10.1101/2024.12.23.630090 — biophysics — Posted on 2025-04-16

2492 ChromeCRISPR - A High Efficacy Hybrid Machine Learning Model for CRISPR/Cas On-Target Predictions

Daneshpajouh, A.; Fowler, M.; Wiese, K. C.

10.1101/2025.04.16.649183 — bioinformatics — Posted on 2025-04-16

2493 Engineering a membrane-independent human prothrombinase through parsimonious mutation of factor Xa

Ustock, F. I.; Huntington, J. A.

10.1101/2025.04.16.649061 — biochemistry — Posted on 2025-04-16

2494 Discovery of a new evolutionarily conserved short linear F-actin binding motif

Paraschiakos, T.; Yuan, B.; Sopelniak, K.; Bucher, M.; Simon, L.; Zonjic, K.; Eggers, D.; Selle, F.; Li, J.; Linder, S.; Marlovits, T. C.; Windhorst, S.

10.1101/2025.04.16.649135 — biochemistry — Posted on 2025-04-16

2495 Molecular Matchmakers: How ATP and Small Amphiphilic Molecules Fine-Tune FET Proteins Clusters

Kar, M.

10.1101/2025.04.16.649119 — biochemistry — Posted on 2025-04-16

2496 Genomic and Bioinformatic Insights into Enterococcus faecalis from Retail Meats in Nigeria

Osunla, C. A.; Akinbobola, A.; Elshafea, A.; Asare Yeboah, E. E.; Bakare, O. S.; Fayanju, A.; Fatoba, D.; Boamah, B.; Amoako, D. G.

10.1101/2025.04.15.648955 — genomics — Posted on 2025-04-16

2497 Quantifying virus load and characterising virus diversity in wildlife samples with target enrichment sequencing

Bergner, L.; Catalano, S.; Nichols, J.; Filipe, A. D. S.; Cao, X.; Mair, D.; Nankasi, A.; Arinaitwe, M.; Mubangizi, A.; Pybus, O.; Standley, C.; Faust, C. L.; Raghwani, J.

10.1101/2025.04.16.648874 — genomics — Posted on 2025-04-16

2498 Retroelement expansions underlie genome evolution in stingless bees

Araujo, N. d. S.; Azevedo, P.; Ferrari, R. R.; dos Santos, L. B.; Rodriguez, F.; Nocelli, R. C. F.; Hudson, M.; Batista, T. M.; Hartfelder, K.; Aron, S.

10.1101/2025.04.12.648530 — genomics — Posted on 2025-04-16

2499 Characterization of a high-intensity band that cross-reacts with FLAG-M2 antibodies in immunoblots in a subset of laboratory strains of Saccharomyces cerevisiae.

Reid, N. K.; Liang, A. C.; Duncan, M. C.

10.1101/2025.04.15.648968 — cell biology — Posted on 2025-04-16

2500 Characterization of PROTAC specificity and endogenous protein interactomes using ProtacID

Shrestha, S.; Maitland, M. E.; Jing, L.; Duan, S.; Nie, D. Y.; St-Germain, J.; Barsyte-Lovejoy, D.; Arrowsmith, C. H.; Raught, B.

10.1101/2025.04.14.648778 — molecular biology — Posted on 2025-04-16

2501 Synergistic effects of Cyp51 isozyme-specific azole antifungal agents on fungi with multiple cyp51 isozyme genes

Ishii, M.; Ishikawa, K.; Ichinose, K.; Yaguchi, T.; Yamada, T.; Ohata, S.

10.1101/2025.04.16.649168 — microbiology — Posted on 2025-04-16

2502 Disruption of putrescine export in experimentally evolved Ralstonia pseudosolanacearum enhances symbiosis with Mimosa pudica

Cazale, A.-C.; Navarro, M.; Doin de Moura, G. G.; Hoarau, D.; Bellvert, F.; Valiere, S.; Baroukh, C.; Remigi, P.; GUIDOT, A.; CAPELA, D.

10.1101/2025.04.16.649159 — microbiology — Posted on 2025-04-16

2503 Identification and recombinant expression of a novel defluorinase from Rhodococcus jostii RHA1, for defluorination and biotransformation of the PFAS compound 6:2 fluorotelomer carboxylic acid.

Fernando, E. Y.

10.1101/2025.04.16.649145 — microbiology — Posted on 2025-04-16

2504 Loss of the PPE71-esxX-esxY-PPE38 locus drives adaptive transcriptional responses and hypervirulence of Mycobacterium tuberculosis Lineage 2

Koleske, B.; Schill, C.; Rajagopalan, S.; Shee, S.; Martinez-Martinez, Y. B.; Gupta, M.; Shen, J.; Jacobs, W. R.; Bishai, W. R.

10.1101/2025.04.16.649112 — microbiology — Posted on 2025-04-16

2505 HilE mediates motility thermoregulation in typhoidal Salmonella serovars at elevated physiological temperatures

Shem-Tov, R.; Gal-Mor, O.

10.1101/2025.04.16.649069 — microbiology — Posted on 2025-04-16

2506 Microbial communities in Caldicellulosiruptor spp. pretreatment vessels and anaerobic digesters fed dairy manure

Young, J.; Nipko, M. A.; Butterfield, S.; Aanderud, Z.

10.1101/2025.04.16.649167 — microbiology — Posted on 2025-04-16

2507 Use of ANCHOR viruses to validate radiative, physical and chemical decontamination systems in operational conditions.

Gallardo, F.; Poirier, V.; Quentin-Froignant, C.; Figueroa, T.; Volmer, R.; Mousnier, M.; Authier, O.; Lainisalo, D.; Lainisalo, P.; Ingelius, T.; Grandadam, M.; Marcheteau, E.

10.1101/2025.04.15.648913 — microbiology — Posted on 2025-04-16

2508 Start&Stop - a PhysiCell and PhysiBoSS 2.0 add-on for interactive simulation control

Smeriglio, R.; Bardini, R.; Savino, A.; Di Carlo, S.

10.1101/2024.12.13.628298 — bioinformatics — Posted on 2025-04-16

2509 A Novel Technique for Fluorescence Lifetime Tomography

Nizam, N. I.; Pandey, V.; Erbas, I.; Bracher, N. L.; Smith, J. T.; Intes, X.

10.1101/2024.09.19.613888 — bioengineering — Posted on 2025-04-16

2510 A Large Language Model Guides the Affinity Maturation of Variant Antibodies Generated by Combinatorial Optimization

Ashraf, F. B.; Paco, K.; Zhang, Z.; Ojeda, C. J. D.; Mendivil, M. P.; Lay, J. A.; Yang, T. Y.; Silva, F. L. B. d.; Sazinsky, M. H.; Ray, A.; Lonardi, S.

10.1101/2024.12.19.629473 — molecular biology — Posted on 2025-04-16

2511 Clostridioides difficile in Equidae necropsied in north-western France, in 2019-2021: common carriage of toxigenic strains and virulence of emerging ribotype 017

Petry, S.; Tapprest, J.; Maillard, K.; Barbut, F.; DUQUESNE, F.; Kozak, S.; FOUCHER, N.; BERNEZ-ROMAND, M.; Bridoux, L.; Poquet, I.

10.1101/2024.09.30.615820 — microbiology — Posted on 2025-04-16

2512 ENTPD3-specific CAR Regulatory T cells for Local Immune Control in T1D

Pieper, T.; Riet, T.; Saetzler, V.; McGovern, J.; Delsing, L.; Atkinson, M.; Lodie, T.; Jermutus, L.; Noyan, F.; Hust, M.; Kusmartseva, I.; Hagedorn, M.; Lieber, M.; Henschel, P.; Glaser, V.; Geffers, R.; Polansky-Biskup, J.; Yang, M.; Eiz-Vesper, B.; Bonifacius, A.; Martinez Llordella, M.; Bergerhoff, K.; Henry, L.; Penston, D.; Gavriil, A.; Grothier, T.; Nikolopoulou, E.; Demertzis, N.; Koullourou, V.; Cox, P.; Zarrouki, B.; Sini, M.; Pfeiff, J.; Matthiesen, I.; Hardtke-Wolenski, M.; Jaeckel, E.

10.1101/2024.11.12.622951 — immunology — Posted on 2025-04-16

2513 The development of aperiodic neural activity in the human brain

Cross, Z. R.; Gray, S. M.; Dede, A. J. O.; Rivera, Y. M.; Yin, Q.; Vahidi, P.; Rau, E. M. B.; Cyr, C.; Holubecki, A. M.; Asano, E.; Lin, J. J.; McManus, O. K.; Sattar, S.; Saez, I.; Girgis, F.; King-Stephens, D.; Weber, P. B.; Laxer, K. D.; Schuele, S. U.; Rosenow, J. M.; Wu, J. Y.; Kam, S. K.; Raskin, J. S.; Chang, E. F.; Shaikhouni, A.; Brunner, P.; Roland, J. L.; Braga, R. M.; Knight, R. T.; Ofen, N.; Johnson, E. L.

10.1101/2024.11.08.622714 — neuroscience — Posted on 2025-04-16

2514 Immunocompetent murine models recapitulate the heterogeneous tumor immune microenvironment of human liposarcoma

Shafer, A. M.; Kenna, E.; Golden, L.-A. F.; Elhossiny, A. M.; Perry, K. D.; Wilkowski, J.; Yan, W.; Kaczkofsky, B.; McGue, J.; Bresler, S. C.; Courtney, A. H.; Dalman, J. M.; Galban, C. J.; Jiang, W.; Espinoza, C. E.; Chugh, R.; Iyer, M. K.; Frankel, T. L.; Pasca di Magliano, M.; Dlugosz, A. A.; Angeles, C. V.

10.1101/2025.01.31.634916 — cancer biology — Posted on 2025-04-16

2515 Identifiability of phenotypic adaptation from low-cell-count experiments and a stochastic model

Browning, A. P.; Crossley, R. M.; Villa, C.; Maini, P. K.; Jenner, A. L.; Cassidy, T.; Hamis, S.

10.1101/2024.08.19.608540 — cancer biology — Posted on 2025-04-16

2516 Four Individually Identified Paired Dopamine Neurons Signal Taste Punishment in Larval Drosophila

Weber, D.; Vogt, K.; Miroschnikow, A.; Pankratz, M. J.; Thum, A. S.

10.1101/2023.07.26.550661 — animal behavior and cognition — Posted on 2025-04-16

2517 PISA: a versatile interpretation tool for visualizing cis-regulatory rules in genomic data

McAnany, C. E.; Weilert, M.; Kamulegeya, F.; Mehta, G.; Gardner, J. M.; Kundaje, A.; Zeitlinger, J.

10.1101/2025.04.07.647613 — genomics — Posted on 2025-04-16

2518 Asymmetric Interactions Shape Survival During Population Range Expansions

Gray, J. M.; Scott, J. G.; Barker-Clarke, R. J.; Hinczewski, M.

10.1101/2024.12.14.628506 — evolutionary biology — Posted on 2025-04-16

2519 Regionalized regulation of actomyosin organization influences cardiomyocyte cell shape changes during chamber curvature formation

Leerberg, D. M.; Avillion, G.; Priya, R.; Stainier, D. Y. R.; Yelon, D.

10.1101/2025.01.07.631779 — developmental biology — Posted on 2025-04-16

2520 The scaffolding and activation of NLRP3 on acidic vesicles depends on their biophysical properties and is independent of intermediate filaments

de Paz Linares, G. A.; Mossemann, J.; Sayed, B.; Freeman, S. A.

10.1101/2024.11.18.624139 — cell biology — Posted on 2025-04-16

2521 PARP14 is an interferon (IFN)-induced host factor that promotes IFN production and affects the replication of multiple viruses

Parthasarathy, S.; Saenjamsai, P.; Hao, H.; Ferkul, A.; Pfannenstiel, J. J.; Bejan, D. S.; Chen, Y.; Suder, E. L.; Schwarting, N.; Aikawa, M.; Muhlberger, E.; Hume, A. J.; Orozco, R. C.; Sullivan, C. S.; Cohen, M. S.; Davido, D.; Fehr, A.

10.1101/2024.04.26.591186 — microbiology — Posted on 2025-04-16

2522 Identifying Genetic Variations in emm89 Streptococcus pyogenes Linked to Severe Invasive Infections

Ono, M.; Yamaguchi, M.; Motooka, D.; Hirose, Y.; Higashi, K.; Sumitomo, T.; Miyoshi-Akiyama, T.; Okuno, R.; Yamaguchi, T.; Kawahara, R.; Otsuka, H.; Nakanishi, N.; Kazawa, Y.; Nakagawa, C.; Yamaguchi, R.; Sakai, H.; Matsumoto, Y.; Ikebe, T.; Kawabata, S.

10.1101/2024.07.02.601674 — microbiology — Posted on 2025-04-16

2523 High Cognitive Violation of Expectations is Compromised in Cerebellar Ataxia

Daniel, L. A.; Vakil, E.; Saban, W.

10.1101/2025.01.11.632539 — neuroscience — Posted on 2025-04-16

2524 Adaptive Reinforcement Learning is causally supported by Anterior Cingulate Cortex and Striatum

Treuting, R. L.; Boroujeni, K. B.; Gerrity, C. G.; Neumann, A.; Tiesinga, P.; Womelsdorf, T.

10.1101/2024.06.12.598723 — neuroscience — Posted on 2025-04-16

2525 Cortical population coding critically depends on fine-tuning of cell physiology

Revah, O.; Wolf, F.; Gutnick, M. J.; Neef, A.

10.1101/2024.02.15.580451 — neuroscience — Posted on 2025-04-16

2526 Integrative spatial transcriptomic analysis pinpoints the role of the ferroxidase, TaMCO3, in wheat root tip iron mobilization

Joon, R.; Singh, G.; Tyagi, D.; Meena, V.; Shukla, V.; Agrwal, K.; Saini, S.; Jot, M.; Banoo, H.; Satbhai, S.; Singh, J.; Long, T.; Ramireddy, E.; PANDEY, A. K.

10.1101/2025.01.22.634289 — plant biology — Posted on 2025-04-16

2527 RAB1A is a novel vulnerability in uveal melanoma revealed by dual inhibition of MNK1/2 and mTOR.

Flores Gonzalez, R. E.; Goncalves, C.; Wirasinghe, N.; Gaudeault, V.; Noda Ferro, J. M.; Coutant, K.; Mitchell, A.; Guettler, E.; Gonzalez Moreno, D. R.; Preston, S.; Cai, F.; Gagnon, N.; Jean, S.; Landreville, S.; Miller, W. H.; Del Rincon, S. V.

10.1101/2025.02.23.639782 — cancer biology — Posted on 2025-04-16

2528 NetSyn: genomic context exploration of protein families

Stam, M.; Langlois, j.; Chevalier, C.; Mainguy, J.; Reboul, G.; Bastard, K.; Medigue, C.; Vallenet, D.

10.1101/2023.02.15.528638 — bioinformatics — Posted on 2025-04-16

2529 Learning Biophysical Dynamics with Protein Language Models

Hou, C.; Zhao, H.; Shen, Y.

10.1101/2024.10.11.617911 — bioinformatics — Posted on 2025-04-16

2530 Impacts on the microbial fungal communities across water, sediment, and amphibian hosts across an urbanization gradient waterway in Worcester, Massachusetts

Wheeler, S. J.; DelCogliano, M.; Hare, B.; Bradshaw, A. J.; Hincher, M. R.; Carleton, J. P.; Bergmann, P. J.; Ahlgren, N. A.; Tabima, J. F.

10.1101/2025.04.01.646624 — ecology — Posted on 2025-04-16

2531 A cellular basis for the mammalian nocturnal-diurnal switch

Beale, A. D.; Christmas, M. J.; Rzechorzek, N. M.; Mihut, A.; Zeng, A.; Ellis, C.; James, N. R.; Smyllie, N. J.; Pilorz, V.; Richardson, R.; Bertelsen, M. F.; Fazal, S. V.; Voysey, Z.; Moreau, K.; Pelletier, J.; Crosby, P.; Peak-Chew, S. Y.; Edgar, R. S.; Lancaster, M. A.; Hut, R. A.; O'Neill, J. S.

10.1101/2023.06.22.546020 — cell biology — Posted on 2025-04-16

2532 Submitochondrial Protein Translocation in Thermogenic Regulation

Haczeyni, F.; Jordan, J. M.; Stein, B. D.; Steensels, S.; Li, L.; Dartigue, V.; Sarklioglu, S.; Qiao, J.; Zhou, X. K.; Dannenberg, A. J.; Iyengar, N.; Yu, H.; Cantley, L. C.; Ersoy, B. A.

10.1101/2023.05.04.539294 — molecular biology — Posted on 2025-04-16

2533 Humanized mouse models to support therapeutic development for SYNGAP1 and STXBP1 disorders

Felix, A. J.; Brown, B. L.; Marotta, N.; Gessner, M. J.; Wilson, T.; Randell, R.; Dawicki-McKenna, J.; Reinhardt, D.; Uchida, K.; Boland, M. J.; Davidson, B. L.; Prosser, B. L.

10.1101/2024.08.22.609238 — neuroscience — Posted on 2025-04-16

2534 Fiber Microstructure Quantile (FMQ) Regression: A Novel Statistical Approach for Analyzing White Matter Bundles from Periphery to Core

Lan, Z.; Chen, Y.; Rushmore, J.; Zekelman, L.; Makris, N.; Rathi, Y.; Golby, A. J.; Zhang, F.; O'Donnell, L. J.

10.1101/2024.10.19.619237 — neuroscience — Posted on 2025-04-16

2535 Somites are a source of nephron progenitors in zebrafish

Davidson, A. J.; Peng, Z.; Vanichapol, T.; Nguyen, P. D.; Chang, H.-H. G.; Kocha, K. M.; O'Brien, L.; Currie, P.; Huang, P.

10.1101/2025.04.15.649022 — developmental biology — Posted on 2025-04-16

2536 DNA Methylation in Sex Chromosomes and Genes under Selection Underpins the Emergence of Sexual Size Dimorphism

Wang, Q.; Hao, X.; Anastasiadi, D.; Liu, K.; Li, S.; Feng, B.; Wang, R.; Ritchie, M. G.; Liu, Y.; Wang, H.; Tang, L.; Piferrer, F.; Shao, C.

10.1101/2025.04.14.648707 — developmental biology — Posted on 2025-04-16

2537 Deciphering of single-cell chromatin accessibility and transcriptome reveals the discrepancy for ex vivo human erythropoiesis

Xin, Z.; Zhang, W.; Zhang, L.; Zheng, G.; Jin, T.; Li, M.; Shao, Y.; Dou, L.; Huang, S.; Zhang, Z.; Fang, X.

10.1101/2025.04.15.648947 — developmental biology — Posted on 2025-04-16

2538 Psmd13, a proteosome regulatory subunit identified in miR-29a regulation during neurogenesis

Kuriakose, D.; Morahan, G.; Xiao, Z.

10.1101/2025.04.14.648858 — developmental biology — Posted on 2025-04-16

2539 PROX1 Controls Cellular Patterning, Innervation and Differentiation in the Mouse Organ of Corti

Kale, S.; Traenkner, D.; Goodrich, E. J.; Ghimire, S. R.; Coate, T. M.; Deans, M. R.

10.1101/2025.04.15.649013 — developmental biology — Posted on 2025-04-16

2540 Primary and secondary microplastics do not affect hatching of Japanese flounder eggs

Azmi, S. S.; SEONG, T.; KIM, H.-J.; NAKATANI, H.; KYOZUKA, Y.; ASAKURA, H.; SHIMIZU, K.; Yagi, M.

10.1101/2025.04.15.648670 — developmental biology — Posted on 2025-04-16

2541 Mechanics regulate the postembryonic developmental maturation and function of sensory neurons in a pre-vertebrate chordate.

Midlang, A.; Jones, C. M.; Seegers, L.; Hoyer, J.; Glorstad, S.; Chatzigeorgiou, M.

10.1101/2025.04.16.649091 — developmental biology — Posted on 2025-04-16

2542 Changes in nuclear and actin mechanics from G1 to G2 affect nuclear integrity

Bunner, S.; Huang, K.; Shah, A.; Lang, N. D.; Chu, C.; Figueroa, S.; Eskndir, N.; Pho, M.; Manning, G.; Fritz-Laylin, L.; Velle, K. B.; Marcus, J.; Orth, J.; Stephens, A. D.

10.1101/2025.04.16.649171 — cell biology — Posted on 2025-04-16

2543 Prediction of quantitative function of artificially-designed protein from structural information

Ota, R.; Sakamoto, M.; Aoki, W.; Naoki, H.

10.1101/2025.04.10.648284 — bioinformatics — Posted on 2025-04-16

2544 Intestinal Tissue Mechanics Regulate Angiogenesis and Stem Cell Proliferation via Vascular Piezo

Cordero, J. B.; Phillips, J. A.; Perochon, J.; Johnson, C. T.; Walker, M.; Nixon, C.; Hughes, M.; Barros Carvalho, A.; Yu, Y.; Mitchell, L.; Blyth, K.; Vassalli, M.

10.1101/2025.04.16.649133 — developmental biology — Posted on 2025-04-16

2545 FGF overactivation underlies reduced neurogenesis in cerebellar organoid models of neurodevelopmental ciliopathy

Brunetti, L.; Wiegering, A.; Anselme, I.; Pollara, L.; Catala, M.; Antoniewski, C.; Valente, E. M.; Schneider-Maunoury, S.; Vesque, C.

10.1101/2025.04.14.648790 — developmental biology — Posted on 2025-04-16

2546 Pluripotent Stem Cell Plasticity is Sculpted by a Slit-Independent Robo Pathway in a Regenerative Animal

Wang, K.-T.; Chen, Y.-C.; Tsai, F.-Y.; Judy, C. P.; Adler, C. E.

10.1101/2025.04.14.648795 — developmental biology — Posted on 2025-04-16

2547 Spatial activation of Kinesin-1 by Ensconsin shapes microtubule networks via ncMTOCs recruitment

Berisha, A.-M.; Pascal, A.; Guelle, M.; clement, B.; Chretien, D.; Bataille, L.; GIET, R.

10.1101/2025.04.15.648882 — developmental biology — Posted on 2025-04-16

2548 Unilateral loss of recql4 function in Xenopus laevis tadpoles leads to ipsilateral ablation of the forelimb, hypoplastic Meckel's cartilage and vascular defects.

Beck, C. W.; Riley-Bell, M.; Bicknell, L.

10.1101/2025.04.14.648861 — developmental biology — Posted on 2025-04-16

2549 Autophagy-Dependent Regulation of YAP1 by STK38 Governs Recruitment of Differentiated Cells as Progenitor Cells During Regeneration

Zeng, Y.; Huang, Y.-Z.; Li, Q. K.; Ho, R.; Bark, S. J.; Willet, S. G.; Mills, J. C.

10.1101/2025.04.14.648819 — developmental biology — Posted on 2025-04-16

2550 Unraveling Enteroendocrine Cell lineage dynamics and associated gene regulatory networks during intestinal development

Jimenez, S.; Blot, F.; Meunier, A.; Schreiber, V.; Giethlen, C.; Ghimire, S.; Mahe, M.; Molina, N.; De Arcangelis, A.; Gradwohl, G.

10.1101/2025.04.11.648332 — developmental biology — Posted on 2025-04-16

2551 Enhanced Tactile Coding in Rat Neocortex Under Darkness

Yamashiro, K.; Shiyori, T.; Matsumoto, N.; Ikegaya, Y.

10.1101/2025.04.11.648316 — neuroscience — Posted on 2025-04-16

2552 Finite element model predicts micromotion-induced strain profiles that correlate with the functional performance of Utah arrays in humans and non-human primates

Forrest, A. M.; Kunigk, N. G.; Collinger, J. L.; Gaunt, R.; Chen, X.; Vande Geest, J. P.; Kozai, T. D. Y.

10.1101/2025.04.10.648248 — neuroscience — Posted on 2025-04-16

2553 CXCL16 mediates nociception and inflammation in murine post-traumatic osteoarthritis

Lammlin, L.; Redding, S.; Knights, A. J.; Mohan, A.; Newton, M. D.; Bergman, R. F.; Smith, I. J.; Howser, S. C.; Gonzalez-Nolde, S.; Rzeczycki, P. M.; Adamczyk, N. S.; Miller, R. E.; Maerz, T.

10.1101/2025.04.10.647297 — physiology — Posted on 2025-04-16

2554 Pangebin: improving plasmid binning in bacterial isolates using pangenome-assembly graphs.

Sgro, M.; Brejova, B.; Vinar, T.; Priola, Y.; Bonizzoni, P.; Chauve, C.

10.1101/2025.04.10.648291 — bioinformatics — Posted on 2025-04-16

2555 Computational Evaluation of Phytochemicals as Potential Anti-HIV Drugs Targeting CCR5 and CXCR4 Receptors

Nebir, S. S.; Al Arian, T.; Sarkar, B.; Moni, R.; Malek, S.; Zohora, U. S.; Rahman, M. S.

10.1101/2025.04.10.648243 — bioinformatics — Posted on 2025-04-16

2556 Isolation and Characterization of Strains used in Bacterial-Based Strategies for Accelerated Carbonation of Lime Mortars

Grosso Giordano, F.; Marien, Q.; Rodriguez-Navarro, C.; De Belie, N.; Boon, N.

10.1101/2025.04.10.648092 — bioengineering — Posted on 2025-04-16

2557 Item recognition is associated with gut microbiota composition in healthy humans

Oyarzun, J. P.; Kuntz, T. M.; Morgan, X. C.; Davachi, L.; Huttenhower, C.; LeDoux, J. E.; Phelps, E. A.

10.1101/2025.04.10.648258 — animal behavior and cognition — Posted on 2025-04-16

2558 The identification and characterization of hillocks in the postnatal mouse and human airway

Otto, Y.; Shipkovenska, G.; Liu, Q.; Sun, J.; Hariri, L. P.; Shah, V.; Rajagopal, J.

10.1101/2025.04.15.648833 — developmental biology — Posted on 2025-04-16

2559 Aberrant formation of long-range projections across different neurodevelopmental disorders converges on molecular and cellular nexuses

Furlanetto, F.; Segura, A.; Kravikass, M.; Dolai, P.; Frank, S.; Turan, S.; Luna, A.; Kaeseberg, S.; Schweiger, S.; Lie, C. D.; Zaburdaev, V.; Karow, M.; Falk, S.

10.1101/2025.04.15.648981 — developmental biology — Posted on 2025-04-16

2560 tRNA-derived RNA processing in sperm transmits non-genetically inherited phenotypes to offspring in C. elegans

Galambos, N. S.; Crocker, O. J.; Schneider, B. K.; Allerton, K. S.; Gross, K. E.; Schneider, A. E.; Lynch, J.; Yukselen, O.; Kucukural, A.; Conine, C. C.

10.1101/2025.04.14.648817 — developmental biology — Posted on 2025-04-16

2561 FGF8 promotes lipid droplet accumulation via the FGFR1/p-p38 axis in chondrocytes

huang, m.; chen, h.; wei, j.; pi, c.; duan, m.; pu, x.; niu, z.; xu, s.; tu, s.; liu, s.; li, j.; zhang, l.; liu, y.; chen, h.; xu, c.; xie, j.

10.1101/2025.04.15.648880 — cell biology — Posted on 2025-04-16

2562 Single cell mapping of the metabolic landscape of skin fibrosis in systemic sclerosis

Devakumar, V.; Li, Y.-N.; Filla, T.; Rigau, A. R.; Gyorfi, A.-H.; Tuemerdem, B. S.; Neelagar, R.; Liang, M.; Bergmann, C.; Schett, G.; Distler, J. H. W.; Matei, A.-E.

10.1101/2025.04.14.648761 — cell biology — Posted on 2025-04-16

2563 Back to basics: Immunoglobulin germline reference sequences enable investigations and reveal insights into bat-specific immunity

Reers, A. B.; Zhan, S.; Pursell, T.; Reasoner, C.; Hodges, N.; Lama, T. M.; Schountz, T.; Frank, H. K.

10.1101/2025.04.10.648212 — immunology — Posted on 2025-04-16

2564 High-performance proteomics at any chromatographic flow rate

tsiklauri, g.; Zheng, R.; Kabella, N.; Prokofeva, P.; Pynn, C.; Kuster, B.

10.1101/2025.04.10.648108 — systems biology — Posted on 2025-04-16

2565 2-Oxoglutarate-dependent dioxygenases contribute to cardenolide biosynthesis in Erysimum cheiranthoides (wormseed wallflower)

Younkin, G.; Holland, C. K.; Jander, G.

10.1101/2025.04.10.648230 — plant biology — Posted on 2025-04-16

2566 THE FUNCTION AND EVOLUTION OF STEGOSAUR OSTEODERMS AND HYPOTHESIZED SEXUAL DIMORPHISM IN HESPEROSAURUS

Saitta, E. T.; Bonhomme, V.; Lukens, M.; Vidal, D.; Longrich, N. R.; Richmond, D. R.; Stockdale, M. T.

10.1101/2025.04.10.648273 — paleontology — Posted on 2025-04-16

2567 Fractal Measures as Predictors of Histopathological Complexity in Breast Carcinoma Mammograms

Das, A.; Bhat, R.; Jolly, M. K.

10.1101/2025.04.10.648305 — biophysics — Posted on 2025-04-16

2568 Benchmarking single cell transcriptome matching methods for incremental growth of reference atlases

Hu, J.; Peng, B.; Pankajam, A. V.; Xu, B.; Deshpande, V. A.; Bueckle, A. D.; Herr, B. W.; Borner, K.; Dupont, C. L.; Scheuermann, R. H.; Zhang, Y.

10.1101/2025.04.10.648034 — bioinformatics — Posted on 2025-04-16

2569 A Benchmarking Platform for Assessing Protein Language Models on Function-related Prediction Tasks

Cevrim, E.; Yigit, M. G.; Ulusoy, E.; Yilmaz, A.; Dogan, T.

10.1101/2025.04.10.648084 — bioinformatics — Posted on 2025-04-16

2570 MRI-free Virtual Neuronavigation for TMS

Valter, Y.; Truong, D. q.; Kawasumi, Y.; Bikson, M.; Datta, A.

10.1101/2025.04.10.648190 — bioengineering — Posted on 2025-04-16

2571 Transcription factor reveals interconnected regulation of carbon source utilization and carbon catabolite repression in an oleaginous yeast

Reyes-Chavez, B.; Kerkaert, J. D.; Huberman, L. B.

10.1101/2025.04.10.648202 — genetics — Posted on 2025-04-16

2572 Single-Cell eQTL Mapping Reveals Cell Type-Specific Genetic Regulation in Lung Cancer

Fu, Y.; Wang, Y.; Zhang, C.; Jin, C.; Cai, J.; Gong, L.; Jin, C.; Ji, C.; Mou, Y.; Zhang, C.; Wu, S.; Ge, X.; Dai, Y.; Miao, S.; Ma, H.; Ma, X.; Wang, M.; Bian, L.; Zhang, E.; Dai, J.; Hu, Z.; Jin, G.; Zhu, M.; Shen, H.; Ma, H.

10.1101/2025.04.10.646767 — genetics — Posted on 2025-04-16

2573 Range and elevation predict responses to climate change in frogs and lizards in the Western Ghats biodiversity hotspot of peninsular India

Marathe, A.; Vijaykumar, S.; Torsekar, V.; Dinesh, K.; Pal, S.; Achyuthan, S.; Shanker, K.

10.1101/2025.04.10.648234 — ecology — Posted on 2025-04-16

2574 Retinoic acid signaling alters the balance of epidermal stem cell populations in the skin

Dumrongphuttidecha, T.; Ishikawa, M.; Cabezas-Wallscheid, N.; Sada, A.

10.1101/2025.04.10.648290 — developmental biology — Posted on 2025-04-16

2575 Single cell spatial transcriptomics integration deciphers the morphological heterogeneity of atherosclerotic carotid arteries

Pauli, J.; Garger, D.; Peymani, F.; Wettich, J.; Sachs, N.; Wirth, J.; Zhang, H.; Tabas, I.; Tall, A.; Li, M.; Reilly, M.; Branzan, D.; Prokisch, H.; Menden, M. P.; Maegdefessel, L.

10.1101/2025.04.16.649077 — cell biology — Posted on 2025-04-16

2576 A non-invasive method for profiling the gut microbiome and virome of honey bee queens

Holmes, L. A.; Wolf Veiga, P.; Pettis, J.; Guarna, M. M.; Hoover, S. E.

10.1101/2025.04.15.648983 — microbiology — Posted on 2025-04-16

2577 Dextran-based T-cell expansion nanoparticles for manufacturing CAR T cells with augmented efficacy

Zheng, T.; Ramanathan, K.; Ormhoj, M.; Hansen, M. R.; Halldorsdottir, H. R.; Li, H.; Munk, K. K.; Rodriguez-Pardo, C.; Friis, R. U. W.; Islam, S. F.; Heegaard, P. M. H.; Qvortrup, K.; Abken, H.; Sun, Y.; Hardup, S. R.

10.1101/2025.04.10.648181 — immunology — Posted on 2025-04-16

2578 A Spray Dried Replicon Vaccine Platform for Pandemic Response

McClary, W. D.; Chen, J. Z.; Wang, H.; Lo, E.; Bakken, J.; McCollum, J.; Press, C.; Melief, E.; Brandt, D. S.; Martin, A. R.; Vehring, R.; Kasal, D. N.; Voigt, E. A.; Gerhardt, A.

10.1101/2025.04.10.648241 — immunology — Posted on 2025-04-16

2579 Submicron-Sampling of Living Cells by Macrophages

Fan, A. C.; Thota, R.; Serwas, N.; Marchuk, K.; Ruhland, M.; Edwards, A.; Krummel, M. F.

10.1101/2025.04.10.648051 — immunology — Posted on 2025-04-16

2580 Enhance Memory CD8+ T Cell Formation via Downregulation of Hematopoietic Progenitor Kinase 1 and Sustained Mitochondrial Fitness

Yang, L.; Wang, T.; Guan, X.; He, C.; Shi, H.; Wu, H.; Liao, X.

10.1101/2025.04.10.648158 — immunology — Posted on 2025-04-16

2581 Posterior parietal cortex activity during visually cued gait: a preliminary study

McDonnell, P.; Grimmitt, A. B.; Moreno-Jaramillo, J.; Hoogkamer, W.; Martini, D. N.

10.1101/2025.04.10.648269 — neuroscience — Posted on 2025-04-16

2582 Design and Biological Activity of a Novel Brain Penetrant Urea Compound Against Glioblastoma

He, L.; Chen, X.; Deng, H.; Azizad, D.; Hoffman, C.; Azizi, L.; Elezi, G.; Zhuang, Z.; Cardenas, A. M.; Calseron, C.; Mohammadi, M.; Tate, S.; Whitelegge, J. P.; Li, G.; Zuckerman, J.; Damoiseaux, R.; Bhaduri, A.; Liau, L.; Kornblum, H.; Jung, M. E.; Pajonk, F.

10.1101/2025.04.10.648292 — neuroscience — Posted on 2025-04-16

2583 Juvenile mice are susceptible to infarct-induced neurodegeneration that causes delayed cognitive decline in a new model of pediatric ischemic stroke

Mayne, E. W.; Vanden, K.; Zera, K.; Buckwalter, M. S.

10.1101/2025.04.10.648083 — neuroscience — Posted on 2025-04-16

2584 Domain-general neural effects of associative learning and expectations on pain and hedonic taste perception

Zhao, Y.; Lee, I.; Rose-McCandlish, M.; Yu, Q.; Mischkowski, D.; Avery, J. A.; Ingeholm, J. E.; Reynolds, R. C.; Chen, G.; Atlas, L. Y.

10.1101/2025.04.10.648205 — neuroscience — Posted on 2025-04-16

2585 hiPSC-derived astrocytes from individuals with schizophrenia induce a dystrophic phenotype in microglial-like cells

Cardozo, P. L.; Lee, C.-Y.; Lacerda, J. P. S.; Fahel, J. S.; Trindade, P.; Vitoria, G.; Chicaybam, L.; Cordeiro, R. C.; de Faria, I. J. S.; Silva, N. C.; Todjro, Y. M. H.; Maciel, J. C. d. P.; Bonamino, M. H.; Vieira, L. B.; Cruz, B. F.; Nicolato, R.; Brennand, K. J.; Rehen, S. K.; Ribeiro, F. M.

10.1101/2024.09.20.614161 — neuroscience — Posted on 2025-04-16

2586 The influence of surfactin and glutamate on tomato root association by plant growth promoting rhizobacteria Bacillus subtilis

Warthen, R.; Cabales, A.; Wockenfuss, A.; Kunjapur, A. M.; Bais, H.

10.1101/2025.04.10.647820 — plant biology — Posted on 2025-04-16

2587 Sexually distinct multi omic responses to progressive endurance exercise training in the rat lung. Findings from MoTrPAC

Many, G.; Sagendorf, T. J.; Mitchell, H. D.; Sanford, J. A.; Cohen, S.; Misra, R.; Estevao, I. L.; Diaz Ludovico, I.; Gaul, D. A.; Lindholm, M. E.; Ushakumary, M. G.; Pino, J.; Musi, N.; Nie, J.; Fernandez, F.; Ortlund, E. A.; Esser, K. A.; Bodine, S. C.; Schenk, S.; Clair, G. C.; Adkins, J. N.

10.1101/2025.04.10.647997 — physiology — Posted on 2025-04-16

2588 Multi-behavioral phenotyping in early-life-stage zebrafish for identifying disruptors of non-associative learning

Leuthold, D.; Herold, N. K.; Nerlich, J.; Bartmann, K.; Scharkin, I.; Hallermann, S. J.; Schweiger, N.; Fritsche, E.; Tal, T.

10.1101/2024.09.25.613874 — pharmacology and toxicology — Posted on 2025-04-16

2589 New insights into the role of oxytocin signaling in preeclampsia

an, S.-M.; jeong, j.; kim, M.; kim, D.; kim, S.; kang, H.-G.; Kim, S.-C.; An, B.-s.

10.1101/2025.04.10.648289 — pathology — Posted on 2025-04-16

2590 Drp1 Proteins Released from Hydrolysis-driven Scaffold Disassembly Trigger Nucleotide-dependent Membrane Remodeling to Promote Scission

Luo, E. W.-C.; Nolden, K. A.; Alimohamadi, H.; Lee, M. W.; Duan, L.; Hill, R. B.; Wong, G. C. L.

10.1101/2025.04.10.648288 — biophysics — Posted on 2025-04-16

2591 PILOT-GM-VAE: Patient-Level Analysis of single cell Disease Atlas with Optimal Transport of Gaussian Mixture Variational Autoencoders

Joodaki, M.; Shaigan, M.; Samiei, S.; Nagai, J.; Maie, T.; Kuppe, C.; G. Costa, I.

10.1101/2025.04.10.648188 — bioinformatics — Posted on 2025-04-16

2592 Disentanglement of batch effects and biological signals across conditions in the single-cell transcriptome

Sakaguchi, S.; Tsutsumi, M.; Nishi, K.; Naoki, H.

10.1101/2025.04.10.648296 — bioinformatics — Posted on 2025-04-16

2593 Inferring non-coding RNA regulatory network from transcriptomic data and curated databases

MA, T.; Ke, H.; Ye, Z.; Feng, L.; Xu, Z.; Pan, R.; Li, E.; Qi, J.; Chen, S.; Liang, M.

10.1101/2025.04.10.648218 — bioinformatics — Posted on 2025-04-16

2594 Predicting 3D Chromatin Interactions Using Transformer-Enhanced Deep Learning Models

Xu, K.; Shen, L.

10.1101/2025.04.10.647995 — bioinformatics — Posted on 2025-04-16

2595 Transcripts with codons that trigger the P-site tRNA-mediated mRNA decay are enriched with optimal codons

Carneiro, R. L.; Palhano, F. L.

10.1101/2025.04.10.648249 — bioinformatics — Posted on 2025-04-16

2596 SCORCH2: a generalised heterogeneous consensus model for high-enrichment interaction-based virtual screening

Chen, L.; Blay, V.; Ballester, P. J.; Houston, D. R.

10.1101/2025.03.31.646332 — bioinformatics — Posted on 2025-04-16

2597 Matrix maturation and cytoskeletal tension define strain thresholds for stretch-induced calcium signaling in human tendon cells

Jaeger, P. K.; Passini, F. S.; Niederoest, B.; Bollhalder, M.; Fucentese, S.; Snedeker, J. G.

10.1101/2025.04.10.648154 — bioengineering — Posted on 2025-04-16

2598 A plug-and-play transepithelial/transendothelial electric resistance (TEER)-upgraded organ-on-chip system to measure barrier dynamics in real-time

Kaden, T.; Besser, S.; Abdo, N.; Mosig, A. S.; Rennert, K.; Nietzsche, S.

10.1101/2025.04.10.648170 — bioengineering — Posted on 2025-04-16

2599 Pigmentation and retinal pigment epithelium thickness: a study of the phenotypic and genotypic relationships between ocular and extraocular pigmented tissues.

Julian, T. H.; Fitzgerald, T.; UK Biobank Eye and Vision Consortium, ; Birney, E.; Sergouniotis, P. I.

10.1101/2024.12.04.626809 — genetics — Posted on 2025-04-16

2600 Distinct satellite DNA composition between core and germline restricted chromosomes in Bradysia (Sciara) coprophila

Kerrebrock, A.; Flynn, J. M.; Baird, R. B.; Hodson, C. N.; Ross, L.; Yamashita, Y. M. M.

10.1101/2025.04.15.648937 — cell biology — Posted on 2025-04-16

2601 Leishmania secretory factor GP63 targets the DICER1/miR-122/hepcidin axis in host macrophages to deplete Nramp1

Samanta, S.; Banerjee, S.; Datta, R.

10.1101/2025.04.16.649108 — cell biology — Posted on 2025-04-16

2602 Muc6-expressing gastric isthmus progenitors contribute to regeneration and metaplasia supported by myeloid-mesenchymal interactions

Arai, J.; Iwata, Y.; Tsubosaka, A.; Kinoshita, H.; Shinohara, S.; Abe, S.; Shiokawa, T.; Oura, K.; Suzuki, N.; Hata, M.; Kurokawa, K.; Oya, Y.; Tsuboi, M.; Ihara, S.; Murakami, K.; Shiomi, C.; Uekura, C.; Fujiwara, H.; Tateno, H.; Mizuno, S.; Takahashi, S.; Kanai, A.; Suzuki, Y.; Ushiku, T.; Ijichi, H.; Hirata, Y.; Kasuga, M.; O'Brien, V. P.; Salama, N.; Kakiuchi, M.; Ishikawa, S.; WANG, T. C.; Hayakawa, Y.; Fujishiro, M.

10.1101/2025.04.15.648856 — cell biology — Posted on 2025-04-16

2603 Macrophages Mediate Antiviral Immunity and Repair of Type 2 Alveolar Epithelial Cells in a Human Stem Cell Model

Turner, D. L.; Baric, H.; Patatsos, K.; Amoozadeh, S.; See, M.; Strumila, K. A.; Murphy, J. T.; Gubbels, L.; Ng, E.; Elefanty, A.; Neeland, M.; Shanthikumar, S.; Londrigan, S. L.; Ramialison, M.; Rossello, F. J.; Stanley, E.; Werder, R. B.

10.1101/2025.04.15.648867 — cell biology — Posted on 2025-04-16

2604 Mitochondrial fission during mitophagy requires both inner and outer mitofissins

Furukawa, K.; Maruyama, T.; Yamashita, S.-i.; Inoue, K.; Fukuda, T.; Noda, N. N.; Kanki, T.

10.1101/2025.04.13.648642 — cell biology — Posted on 2025-04-16

2605 P-Rex1 Limits the Agonist-Induced Internalisation of GPCRs Independently of its Rac-GEF Activity

Baker, M. J.; Hampson, E.; Islam, P.; Pelaez Moral, R.; Maunders, E. A.; Hornigold, K.; Tsonou, E.; Hornigold, D. C.; Hubbard, R. E.; Massey, A. J.; Welch, H. C. E.

10.1101/2025.04.14.648762 — cell biology — Posted on 2025-04-16

2606 Muscle spatial transcriptomic reveals heterogeneous profiles in untreated juvenile dermatomyositis and the persistence of pathological signature after remission

TRAGIN, M.; Periou, B.; Chaigne, B.; Bader-Meunier, B.; Barnerias, C.; Bodemere-Skandalis, C.; Desguerre, I.; Rodero, M.; AUTHIER, F. J.; GITIAUX, C.

10.1101/2025.04.15.648883 — cell biology — Posted on 2025-04-16

2607 M6A reader protein YTHDF3 regulates cardiomyocyte death and atrophy by modulating the alternative splicing program

Gaur, A.; Chaudhary, S.; Sharma, R. K.; Kundu, S.; E, G.; Kumari, R.; Singh, S.; Prakash, S.; Mitra, K.; Kumar, S.; Gupta, S. K.

10.1101/2025.04.15.648887 — cell biology — Posted on 2025-04-16

2608 Archaeal SegAB forms a bipolar structure that promotes chromosome segregation in spherical cells

Charles-Orszag, A.; Lord, S. J.; Herrera, N.; Strauskulage, L.; Bhowmick, A.; Goddard, T.; Wassmer, B.; van Wolferen, M.; Asper, G.; Flis, A.; Rodriguez, J.; Redding, S.; Rosenberg, O.; Albers, S.-V.; Mullins, D.

10.1101/2025.04.15.649018 — cell biology — Posted on 2025-04-16

2609 A Rosella-PLIN2 Knock-in Mouse Reveals Lipophagy and Immunometabolic Interplay in Atherosclerosis

Laval, T.; Joyce, N.; Boucher, D.; Rochon, V.; Emerton, C.; Dharia, M.; Robichaud, S.; Lorant, V.; Nguyen, M.-A.; Geoffrion, M.; Rayner, K. J.; Gibbings, D.; Nutter, L. M. J.; Russell, R. C.; Ouimet, M.

10.1101/2025.04.15.647781 — cell biology — Posted on 2025-04-16

2610 SND1 Impairs Calcium Homeostasis in Right Ventricular Failure by Binding and Destabilizing SERCA2a in Cardiomyocytes

Guo, L.; Liu, X.; Wang, L.; Li, Y.; Zhu, X.; Cheng, X.; Ye, C.; chen, n.; Li, L.; Qin, G.; Wang, Y.; Wang, D.; Qiu, J.; Wang, E.

10.1101/2025.04.14.648853 — cell biology — Posted on 2025-04-16

2611 Mechanisms of nuclear segregation in a multinucleate multibudding yeast

Petrucco, C. A.; Crocker, A. W.; Wirshing, A. C.; Colarusso, A. V.; Waarts, M.; Gladfelter, A. S.; Lew, D.

10.1101/2025.04.14.648742 — cell biology — Posted on 2025-04-16

2612 Clearance of protein aggregates during cell division

Du, S.; Wang, Y.; Chen, B.; Xie, S.; Chan, K. Y.; Hay, D. C.; Chew, T. G.

10.1101/2024.02.10.579754 — cell biology — Posted on 2025-04-16

2613 Investigating the role of molecular coating in human corneal endothelial cell primary culture using artificial intelligence-driven image analysis

TRAVERS, G.; COULOMB, L.; AOUIMEUR, I.; HE, Z.; BONNET, G.; OLLIER, E.; GAVET, Y.; MOISAN, A.; GAIN, P.; THURET, G.; MAURIN, C.

10.1101/2025.04.15.648927 — cell biology — Posted on 2025-04-16

2614 An acyclic nucleoside phosphonate effectively blocks the egress of the malaria parasite by inhibiting the synthesis of cyclic GMP.

Ali, M.; Dura, R.; Guery, M.-A.; Colard-Itte, E.; Cheviet, T.; Robresco, L.; Berry, L.; Lionne, C.; Lavazec, C.; Claessens, A.; Peyrottes, S.; Wengelnik, K.; Wein, S.; Cerdan, R.

10.1101/2025.04.01.645218 — microbiology — Posted on 2025-04-16

2615 Artemin sensitises mouse (Mus musculus) and naked mole-rat (Heterocephalus glaber) sensory neurons

Qiu, L.; Smith, E. S. J.

10.1101/2025.04.10.648171 — neuroscience — Posted on 2025-04-16

2616 Integrative plasma lipidomics and proteomics profiling to decipher potential biomarkers of dilated cardiomyopathy

Saha, S.; Singh, P.; Dutta, A.; Raj, A.; Rathore, M.; Jindal, D.; Vaidya, H.; Kumari, S.; Negi, P. C.; Sengupta, S.; Seth, S.; Basak, T.

10.1101/2025.04.13.648582 — systems biology — Posted on 2025-04-16

2617 Rankings of tuberculosis antibiotic treatment regimens are sensitive to spatial scale, detection limit, and initial host bacterial burden

Michael, C. T.; Budak, M.; Maiello, P.; Kracinovsky, K.; Rodgers, M.; Tomko, J.; Lin, P. L.; Flynn, J. L.; Linderman, J. J.; Kirschner, D.

10.1101/2025.04.10.648004 — systems biology — Posted on 2025-04-16

2618 Apolipoprotein interaction induces shape remodeling and lipid phase separation in giant unilamellar vesicles

Carnahan, C. F.; He, W.; Ozturk, T. N.; Wang, Y.; Ngassam, V. N.; Noy, A.; Carpenter, T. S.; Voss, J. C.; Coleman, M. A.; Parikh, A. N.

10.1101/2025.04.10.648283 — biophysics — Posted on 2025-04-16

2619 AlphaFold3 at CASP16

Elofsson, A.

10.1101/2025.04.10.648174 — bioinformatics — Posted on 2025-04-16

2620 Chronic pain increases sensitivity to pain-induced reinstatement of ethanol seeking in male mice

Nothem, M. A.; Side, C. M.; Tran, S. C.; Brar, A.; Buck, L. A.; Barker, J. M.

10.1101/2025.04.10.648244 — animal behavior and cognition — Posted on 2025-04-16

2621 Transcriptional Landscape of THAP9 across Oligodendrocyte Developmental Stages: Molecular Mechanisms and Network Analysis

Bhardwaj, T.; Patel, D.; Majumdar, S.

10.1101/2025.01.17.633638 — genomics — Posted on 2025-04-16

2622 scContrast: A contrastive learning based approach for encoding single-cell gene expression data

Li, W. Y.; Murtaza, G.; Singh, R.

10.1101/2025.04.07.647292 — genomics — Posted on 2025-04-16

2623 Warm waters undermine cryptic female choice

Kustra, M. C.; Alissa, L. M.; Rogers, M. M.; Molinari, M. M.; Stiver, K. A.; Marsh-Rollo, S.; Hellmann, J. K.; Alonzo, S. H.

10.1101/2025.04.10.648287 — evolutionary biology — Posted on 2025-04-16

2624 Loss of cep57 function induces G1 arrest and microcephaly

Iyer, S.; Gokhale, A.; Murugesan, P. S.; Kumar, M.

10.1101/2025.04.10.648303 — developmental biology — Posted on 2025-04-16

2625 GRHL and PGR control WNT4 expression in the mammary gland via 3D looping of conserved and species-specific enhancers

van de Grift, Y. B.; Aarts, M. T.; Wiese, K. E.; Heijmans, N.; Hooijkaas, I. B.; Pritchard, C. E.; Henneman, L.; Krimpenfort, P. J.; van Boxtel, A. L.; van Amerongen, R.

10.1101/2025.04.11.648333 — developmental biology — Posted on 2025-04-16

2626 Downregulation of O-GlcNAcylation enhances etoposide-induced p53-mediated apoptosis in HepG2 human liver cancer cells

Lee, J.; Han, B.-C.; Koo, G.-B.; Park, J.; Kwon, M.; Lee, S.-H.

10.1101/2024.11.29.626030 — molecular biology — Posted on 2025-04-16

2627 Conservation and evolution of the programmed ribosomal frameshift in prfB across the bacterial domain

Prince, C. R.; Lin, I. N.; Feaga, H. A.

10.1101/2024.09.24.614795 — microbiology — Posted on 2025-04-16

2628 Adaptive Gaze and Hand Coordination while Manipulating and Monitoring the Environment in Parallel

Fooken, J.; Johansson, R. S.; Flanagan, J. R.

10.1101/2024.10.28.620734 — neuroscience — Posted on 2025-04-16

2629 Dissociation of SYNGAP1 Enzymatic and Structural Roles: Intrinsic Excitability and Seizure Susceptibility

Brill, J.; Clarke, B.; Hong, I.; Huganir, R. L.

10.1101/2025.01.14.633019 — neuroscience — Posted on 2025-04-16

2630 Simulations reveal that beta burst detection may inappropriately characterize the beta band

Langford, Z. D.; Wilson, C. R.

10.1101/2023.12.15.571838 — neuroscience — Posted on 2025-04-16

2631 In silico analysis of metabolic burden effects on a multicellular integral controller

Campanile, G.; Martinelli, V.; Salzano, D.; Fiore, D.; di Bernardo, M.

10.1101/2024.11.12.623154 — synthetic biology — Posted on 2025-04-16

2632 Give It Time: Green Anacondas Show Prolonged Behavioral Responses to Enclosure Enhancements

Carvalho, J.; Poinho, M. I.; Morello, G.; Ramos, F.; Magalhaes, A.

10.1101/2025.04.14.648616 — animal behavior and cognition — Posted on 2025-04-16

2633 Mosquito sex under lock and key

Houri-Zeevi, L.; Walker, M. M.; Razzauti, J.; Sharma, A.; Pasolli, H. A.; Vosshall, L. B.

10.1101/2025.04.11.648401 — animal behavior and cognition — Posted on 2025-04-16

2634 Cuttlefish interaction with multimodal arm wave signs displays

Cohen Bodenes, S.; Neri, P.

10.1101/2025.04.13.648584 — animal behavior and cognition — Posted on 2025-04-16

2635 The visual system of the longest-living vertebrate, the Greenland shark

Fogg, L. G.; Tom, E.; Policarpo, M.; Cho, W.; Gao, F.; Grieco, S. F.; Hii, D.; Fawcett, A. E.; Boileau, N.; Bech-Poulsen, A.; Steffensen, K. F.; Ng, C. J.; Bushnell, P. G.; Fleng Steffensen, J.; Brill, R.; Salzburger, W.; Skowronska-Krawczyk, D.

10.1101/2025.04.10.648203 — evolutionary biology — Posted on 2025-04-16

2636 IbinA and IbinB regulate the Toll pathway-mediated immune response in Drosophila melanogaster

Maasdorp, M. K.; Valanne, S.; Vesala, L.; Vornanen, P.; Haukkavaara, E.; Tuomela, T.; Malin, A.; Salminen, T. S.; Hultmark, D.; Rämet, M.

10.1101/2025.04.10.648149 — immunology — Posted on 2025-04-16

2637 Claustrophilic oviposition: oviposition performance depends on container size in a novel forced oviposition method for Culex quinquefasciatus and Aedes aegypti

Dagg, K. A.; Estep, A. S.; Bartz, C. E.; Burgess, E.

10.1101/2025.04.10.648143 — zoology — Posted on 2025-04-16

2638 Engineered protein circuits for cancer therapy

10.1101/2025.04.16.647665 — synthetic biology — Posted on 2025-04-16

2639 Regulating population density through antithetic feedback control of cell growth

Campanile, G.; Martinelli, V.; Salzano, D.; Fiore, D.

10.1101/2025.04.16.648696 — synthetic biology — Posted on 2025-04-16

2640 Arabidopsis ecotype screening reveals novel sources of clubroot resistance and insights into resistance inheritance

Gonzalez-Garcia, M.; Mukhopadhyay, S.; Major, I.; Perez-Lopez, E.

10.1101/2025.04.15.649024 — plant biology — Posted on 2025-04-16

2641 Morphological innovation and lineage-specific history drive disparification in the aggregated pollen of mimosoid plants

Barduzzi, R. F.; Liau-Kang, S.; Duarte, A. F. T.; dos Santos, F. d. A. R.; Borges, L. M.

10.1101/2025.04.16.649038 — plant biology — Posted on 2025-04-16

2642 Rapid population flux in bacterial spot xanthomonads during a transition in dominance between two genotypes in consecutive tomato production seasons and identification of a new species Xanthomonas oklahomensis sp. nov.

Johnson, B.; Subedi, A.; Damicone, J.; Goss, E.; Jones, J. B.; Jibrin, M. O.

10.1101/2025.04.13.648550 — plant biology — Posted on 2025-04-16

2643 InteracTor: Feature Engineering and Explainable AI for Profiling Protein Structure-Interaction-Function Relationships

Silva, J. C. F.; Schuster, L.; Sexson, N.; Erdem, M.; Hulk, R.; Kirst, M.; Resende, M. F. R.; Dias, R.

10.1101/2025.04.10.648139 — bioinformatics — Posted on 2025-04-16

2644 FedPyDESeq2: a federated framework for bulk RNA-seq differential expression analysis

Muzellec, B.; Marteau-Ferey, U.; Marchand, T.

10.1101/2024.12.06.627138 — bioinformatics — Posted on 2025-04-16

2645 Numerical experiments for reconstructing cerebrospinal fluid flow based on contrast enhanced magnetic resonance images in the lower subarachnoid compartments of the brain

Hornkjol, M.; Valnes, L. M.; Mardal, K.-A.

10.1101/2025.04.10.648135 — bioengineering — Posted on 2025-04-16

2646 Polygenic Risk Scores Across Genomic Platforms for Reliable Breast Cancer Risk Stratification

Ho, P. J.; Khng, A. J.; Tan, J. H. J.; Goy, P.-A. V.; Kamila, K. A.; Li, Z.; Ho, W. K.; Tan, I. B. H.; Chong, D. Q.; Lo, E.; Goh, L. L.; Wee, H. L.; Hartman, M.; Dorajoo, R.; Bertin, N.; Li, J.

10.1101/2025.04.10.648141 — genetics — Posted on 2025-04-16

2647 Optimal division asymmetry in E. coli bacteria

Steiner, U. K.; Proenca, A.; Tugrul, M.

10.1101/2025.04.10.648155 — evolutionary biology — Posted on 2025-04-16

2648 Do identification guides hold the key to speciesmisclassification by citizen scientists?

Chadwick, F. J.; Haydon, D. T.; Husmeier, D.; Matthiopoulos, J. J.; Ovaskainen, O.

10.1101/2025.04.10.648156 — ecology — Posted on 2025-04-16

2649 Non-linearity of spatial integration varies across layers of primary visual cortex

Cagnol, R.; Antolik, J.; Palmer, L. A.; Contreras, D.

10.1101/2025.04.10.648107 — neuroscience — Posted on 2025-04-16

2650 Functional validation of human SK channels variants causing NEDMAB and Zimmermann-Laband syndrome-3 in C. elegans

Sechi, S.; Galaup, C.; Jospin, M.; Boulin, T.

10.1101/2025.04.11.648345 — neuroscience — Posted on 2025-04-16

2651 Regulation of input excitability in human and mouse parvalbumin interneurons by Kir potassium channels

Furdan, S.; Douida, A.; Bakos, E.; Tiszlavicz, A.; Molnar, G.; Tamas, G.; Welter, D.; Landry, J.; H. Kovacs, B.; Erdelyi, M.; Bende, B.; Hutoczki, G.; Barzo, P.; Benes, V.; Szegedi, V.; Szucs, A.; Lamsa, K.

10.1101/2025.04.11.648314 — neuroscience — Posted on 2025-04-16

2652 Speciated evolution of oscillatory mass-action chemical reaction networks

Tatka, L.; Smith, L. P.; Sauro, H. M.

10.1101/2025.04.10.648132 — systems biology — Posted on 2025-04-16

2653 Scaling unlocks broader generation and deeper functional understanding of proteins

Bhatnagar, A.; Jain, S.; Beazer, J.; Curran, S. C.; Hoffnagle, A. M.; Ching, K.; Martyn, M.; Nayfach, S.; Ruffolo, J. A.; Madani, A.

10.1101/2025.04.15.649055 — synthetic biology — Posted on 2025-04-16

2654 Compositional selection of phospholipid compartments in icy environments drives the inheritance of encapsulated genetic information

Shinoda, T.; Noda, N.; Watanabe, T.; Kaneko, K.; Tanaka, Y.; Sekine, Y.; Matsuura, T.

10.1101/2025.04.16.648126 — synthetic biology — Posted on 2025-04-16

2655 Precision RNAi in Tomato Using Synthetic Trans-Acting Small Interfering RNAs Derived From Minimal Precursors

Tomassi, A. H.; Juarez-Molina, M.; Cisneros, A. E.; Alarcia, A.; Toledano, S.; Orlando, F.; Presa, S.; Granell, A.; Carbonell, A.

10.1101/2025.04.10.648111 — plant biology — Posted on 2025-04-16

2656 Adenosine and acute low oxygen conditions suppress urinary bladder contractility through the activation of adenosine 2B receptors and large-conductance calcium-activated potassium channels

Herrera, G. M.; Heppner, T. J.; Hennig, G. W.; Rengo, J. L.; Hepp, A. M.; Sancho, M.; Huerta de la Cruz, S.; Nelson, M. T.; Klug, N. R.

10.1101/2025.04.14.648772 — physiology — Posted on 2025-04-16

2657 Structures of Chaetomium thermophilum TOM complexes with bound preproteins

Agip, A.-N. A.; Ornelas, P.; Yang, T.-J.; Uboldi, E.; Haeder, S.; McDowell, M. A.; Kuehlbrandt, W.

10.1101/2025.04.16.649081 — biophysics — Posted on 2025-04-16

2658 Comprehensive evaluation and interpretative insights of peptide-HLA binding prediction tools using explainable artificial intelligence

guojia, w.; xiaochuan, l.; yuting, w.; yang, y.

10.1101/2025.04.10.648169 — bioinformatics — Posted on 2025-04-16

2659 Panalyze: automated virus pangenome variation graph construction and analysis

Tennakoon, C.; Freville, T.; Downing, T.

10.1101/2025.04.10.646565 — bioinformatics — Posted on 2025-04-16

2660 MeDCycFold: A Rosetta Distillation Model to Accelerate Structure Prediction of Cyclic Peptides with Backbone N-methylation and D-amino Acids

Cao, Z.; Shang, T.; Cao, S.; Wang, L.; Wang, Z.; Qingyi, M.; Guo, J.; Duan, H.

10.1101/2025.04.10.648099 — bioinformatics — Posted on 2025-04-16

2661 GenMasterTable: A user-friendly desktop application for filtering, summarising, and visualising large-scale annotated genetic variants

ZHAI, J.; Pitteloud, N.; Santoni, F.

10.1101/2025.04.10.648172 — bioinformatics — Posted on 2025-04-16

2662 Integrative Multi-omics and Supervised Learning Identifies an Epithelial Signature for Radiotherapy Response in Colorectal Cancer

Kumar, R.; Zhou, J.; S:CORT Consortium, ; Beggs, A. D.; Gendoo, D. M. A.

10.1101/2025.04.10.648131 — bioinformatics — Posted on 2025-04-16

2663 Enhanced Kidney Targeting and Distribution of Tubuloids During Normothermic Perfusion

Montagud-Marrahi, E.; Rodriguez-Gonzalo, A.; Lopez-Aladid, R.; Luque, Y.; Rabadan-Ros, R.; Cuadrado-Payan, E.; Banon-Maneus, E.; Rovira, J.; Lazo-Rodriguez, M.; Aguila, O.; Arana, C.; Garcia-Busquets, A.; Hierro, N.; Prudhomme, T.; Musquera, M.; Xia, Y.; Diekmann, F.; Campistol, J. M.; Ramirez-Bajo, M. J.

10.1101/2025.04.10.648123 — bioengineering — Posted on 2025-04-16

2664 Hybrid bioinks for embedded bioprinting of an artery model

Aizarna, U.; Herrero-Ruiz, A.; Caiado-Decarli, M.; Chavarri, K.; Moroni, L.; Henriksen-Lacey, M.; Jimenez de Aberasturi, D.

10.1101/2025.04.10.648100 — bioengineering — Posted on 2025-04-16

2665 Effect of Photoinitiation Process on Photo-Crosslinking of Gelatin Methacryloyl Hydrogel Networks

Duymaz, D.; Karaoglu, I. C.; KIZILEL, S.

10.1101/2025.04.10.648118 — bioengineering — Posted on 2025-04-16

2666 Human Colon Microphysiological System Reproducing Tissue Mechanical Microenvironment With Active Microfluidic Control and Imaging Capacity

ROJAS-GARCIA, D.; HAMEL, D.; FONCY, J.; SAMBE, D.; PEFAURE, S.; MALAQUIN, L.; FERRAND, A.

10.1101/2025.04.10.648106 — bioengineering — Posted on 2025-04-16

2667 Sperm storage reduces sperm and embryo quality in animals

Sanghvi, K.; Dean, R.; Nakagawa, S.; Reinhardt, K.; Sepil, I.; Vega-Trejo, R.

10.1101/2025.04.10.647966 — evolutionary biology — Posted on 2025-04-16

2668 Modelling the effects of adult emergence on the surveillance and age distribution of medically important mosquitoes

Stopard, I. J.; Sherrard-Smith, E.; Ranson, H.; Toe, K. H.; Cook, J.; Biggs, J. R.; Lambert, B.; Churcher, T. S.

10.1101/2025.04.10.648138 — ecology — Posted on 2025-04-16

2669 Isotopic Labeling Analysis using Single Cell Mass Spectrometry

Vu, A.; Caputi, L.; O'Connor, S. E.

10.1101/2025.04.10.647921 — plant biology — Posted on 2025-04-16

2670 A glucosinolate-rich beverage lowers blood lactate concentrations during submaximal exercise

Vinge, F.; Tillqvist, E.; Horwath, O.; Apro, W.; Larsen, F. J.; Sundqvist, M. L.

10.1101/2025.04.15.648889 — physiology — Posted on 2025-04-16

2671 Improved detection of pre-symptomatic, non-central nervous system TDP-43 pathology in amyotrophic lateral sclerosis using RNA aptamer

Waldron, F. M.; Langerova, T.; Read, F. L.; Spence, H.; Hanna, K.; Roberts, K.; Pattle, S. B.; Gregory, J. M.

10.1101/2025.04.10.648122 — pathology — Posted on 2025-04-16

2672 Comparative population genomics reveals convergent adaptation across independent origins of avian obligate brood parasitism

Osipova, E.; Balakrishnan, C. N.; Spottiswoode, C. N.; Lund, L.; DaCosta, J. M.; Hauber, M. E.; Warren, W. C.; Sorenson, M. D.; Sackton, T. B.

10.1101/2025.04.08.647876 — evolutionary biology — Posted on 2025-04-16

2673 Anatomical and Molecular Characterization of the Zebrafish Meninges

Venero Galanternik, M.; Castranova, D.; Gober, R. D.; Nguyen, T.; Kenton, M.; Margolin, G.; Kraus, A.; Sur, A.; Dye, L. E.; Pham, V.; Maese, A.; Holmgren, M.; Gore, A. V.; Samasa, B.; Goldstein, A.; Davis, A. E.; Swearer, A. A.; Iben, J. R.; Li, T.; Coon, S. L.; Dale, R. K.; Farrell, J. A.; Weinstein, B. M.

10.1101/2025.04.09.646894 — developmental biology — Posted on 2025-04-16

2674 Comprehensive annotation of olfactory and gustatory receptor genes and transposable elements revealed their evolutionary dynamics in aphids

Olvera-Vazquez, S. G.; Chen, X.; Mesnil, A.; Meslin, C.; Almeida-Silva, F.; Confais, J.; Bourgeois, Y.; Lougmani, C.; Alix, K.; Choisne, N.; Cauet, S.; Simon, J. C.; Buchard, C.; Rodde, N.; Ogereau, D.; Mottet, C.; Degrave, A.; Segura, E.; Barres, B.; Jacquin-Joly, E.; Marande, W.; Lavenier, D.; Legeai, F.; Cornille, A.

10.1101/2025.04.14.648604 — molecular biology — Posted on 2025-04-16

2675 Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

Ruger-Herreros, C.; Svoboda, L.; Male, G.; Srivastava, A.; Höpfner, M.; Jetzinger, K.; Koubek, J.; Kramer, G.; den Brave, F.; Mogk, A.; Gross, D. S.; Bukau, B.

10.1101/2025.04.14.648540 — molecular biology — Posted on 2025-04-16

2676 Increased Infectivity of Human Cytomegalovirus Strain TB40/E Conferred by Variants of the Envelope Glycoprotein UL128 and the Regulatory Protein IE2

Zhou, X.; Yang, L.; Cimato, G.; Frascaroli, G.; Agueda-Pinto, A.; Hertel, L.; Brune, W.

10.1101/2025.04.09.647953 — microbiology — Posted on 2025-04-16

2677 LPS/TLR4-Activating Exosomes from M1-Polarized Avian Macrophages Enhances IBV Vaccine-Induced Protective Immunity in Chickens

Zhou, J.; Cai, S.; Huang, H.; Yang, F.; Pan, K.; Sun, Z.; Chen, Y.; Fan, Y.; Wen, F.; QIN, L.; Zhang, Y.

10.1101/2025.04.08.647822 — immunology — Posted on 2025-04-16

2678 Dorso-ventral hippocampus neural assemblies reactivate during sleep following an aversive experience

Morici, J. F.; Paiva-Lima, I.; Silva, A.; Pronier, E.; Girardeau, G.

10.1101/2024.06.13.598918 — neuroscience — Posted on 2025-04-16

2679 Evolutionary constraints guide AlphaFold2 prediction of alternative conformations and inform rational mutation design

Piomponi, V.; Cazzaniga, A.; Cuturello, F.

10.1101/2025.04.08.647782 — bioinformatics — Posted on 2025-04-16

2680 Can social interactions rescue "lost" behavioural defences in an allopatric cuckoo host?

Tolman, D.; Rönkä, K.; Kluen, E.; Jolkkonen, J.; Di Bari, P.; Ientile, R.; Campobello, D.; Thorogood, R.

10.1101/2024.01.14.575589 — animal behavior and cognition — Posted on 2025-04-16

2681 Shared Rhythm to Shared Vision: Synchronous Marching increases Conformity on Perceptual Decision making

Biswas, M.; Brass, M.

10.1101/2024.11.21.622221 — animal behavior and cognition — Posted on 2025-04-16

2682 Dispersal evolution can only rescue a limited set of species from climate change

Kamal, P.; Thompson, P. L.; Lewis, N.; Fronhofer, E. A.

10.1101/2024.12.05.626982 — ecology — Posted on 2025-04-16

2683 A mathematical model for cancer dynamics with treatment and saboteur bacteria

Geretovszky, A.; Röst, G.

10.1101/2025.04.10.647988 — cancer biology — Posted on 2025-04-16

2684 Amino acid restriction sensitizes lung cancer cells toferroptosis via GCN2-dependent activation of the integratedstress response

Garrelick, V. J.; Gul, N.; Horrieh, P.; Mustafa, D.; Patel, A. A. H.; Dankis, M.; Alvarez, S. W.; Berndtson, J.; Schwarz, M.; Persson, A.; Zahirovic, F.; Wiel, C.; Sayin, V. I.; Lindahl, P.

10.1101/2025.04.10.648120 — cancer biology — Posted on 2025-04-16

2685 Estimating full-field displacement in biological images using deep learning

Warsop, S. J. E. T.; Caixeiro, S.; Bischoff, M.; Kursawe, J.; Bruce, G. D.; Wijesinghe, P.

10.1101/2024.05.21.595161 — biophysics — Posted on 2025-04-16

2686 IntegrAlign: A comprehensive tool for multiimmunofluorescence panel integration through image alignment

Hermet, L.; Laoubi, L.; Scavino, M.; Doffin, A.-C.; Gazeu, A.; Justine, B.; Pillat, B.; Tissot, S.; Rusakiewicz, S.; Michallet, M.-C.; Bendriss-Vermare, N.; Valladeau-Guilemond, J.; Hausser, J.; Caux, C.; Hubert, M.

10.1101/2025.04.10.648082 — bioinformatics — Posted on 2025-04-16

2687 sampleclusteR: A lightweight R package for automated clustering of transcriptomics samples using metadata

Coke, B.; Niranjan, M.; Ewing, R.

10.1101/2025.04.10.648129 — bioinformatics — Posted on 2025-04-16

2688 Graph-Based Modeling of Alzheimer's Protein Interactions via Spiking Neural, Hyperdimensional Encoding, and Scalable Ray-Based Learning

Zare, S.

10.1101/2025.04.11.647919 — bioinformatics — Posted on 2025-04-16

2689 Glia-mediated gut-brain cytokine signaling couples sleep to intestinal inflammation

Malita, A.; Skakkebaek, A. H.; Kubrak, O.; Chen, X.; Koyama, T.; Connolly, E. C.; Ahrentloev, N.; Andersen, D. S.; Texada, M. J.; Halberg, K.; Rewitz, K.

10.1101/2024.06.25.600726 — animal behavior and cognition — Posted on 2025-04-16

2690 Long-term serial passaging of SARS-CoV-2 reveals signatures of convergent evolution

Foster, C. S. P.; Walker, G. J.; Jean, T.; Wong, M.; Brassil, L.; Isaacs, S.; Lu, Y.; Turville, S. G.; Kelleher, A.; Rawlinson, W. D.

10.1101/2023.11.02.565396 — evolutionary biology — Posted on 2025-04-16

2691 Whole-mount acetylcholinesterase (AChE) staining reveals unique motor innervation of the lamprey oral region: with special reference to the evolutionary origin of the vertebrate jaw

Tamura, M.; Suzuki, D. G.

10.1101/2025.04.10.648078 — developmental biology — Posted on 2025-04-16

2692 Remodeling of RNA-Binding Proteome and RNA-mediated regulation as a new layer of control of sporulation

Kabore, T.; Belghazi, M.; Verthuy, C.; Galinier, A.; Delan-Forino, C.

10.1101/2025.03.21.644579 — microbiology — Posted on 2025-04-16

2693 Loss of transcriptional factor Zbtb33 fails to induce clonal hematopoiesis in mice but plays a role in tumor immunity

Li, Y.; Luo, k.; Liu, J.; Dong, G.; Zhao, Z.; CAI, Z.

10.1101/2025.04.10.648125 — immunology — Posted on 2025-04-16

2694 Hippocampus facilitates reinforcement learning in partially observable environments

Pedamonti, D.; Mohinta, S.; Dimitrov, M.; Malagon-Vina, H.; Ciocchi, S.; Costa, R. P.

10.1101/2023.11.09.565503 — neuroscience — Posted on 2025-04-16

2695 Evidence against a cortical module for processing communicative gaze

Gorner, M.; Dicke, P. W.; Thier, P.

10.1101/2023.01.20.524674 — neuroscience — Posted on 2025-04-16

2696 EEG of the dancing brain: Decoding sensory, motor and social processes during dyadic dance

Bigand, F.; Bianco, R.; Abalde, S. F.; Nguyen, T.; Novembre, G.

10.1101/2024.12.17.628913 — neuroscience — Posted on 2025-04-16

2697 A lipidomic exploration of the effects of high-intensity interval exercise in healthy men after metformin intake

Neuhaus, R.; Meikopoulos, T.; Gradillas, A.; Gonzalez-Riano, C.; Theodoridis, G.; Nikolaidis, S.; Mougios, V.; Barbas, C.; Gika, H.; VILLASENOR, A.

10.1101/2025.04.02.646809 — systems biology — Posted on 2025-04-16

2698 Negligible effect of host DNA on metagenomic analysis enables microbial ecology investigation in historical samples

Ng, S.-K.; Gutaker, R.

10.1101/2025.04.05.647358 — plant biology — Posted on 2025-04-16

2699 Stroke impairs the proactive control of dynamic balance during predictable treadmill accelerations

Cornwell, T. I.; Finley, J. M.

10.1101/2024.10.18.618939 — physiology — Posted on 2025-04-16

2700 IntelliProfiler: a novel software pipeline for analyzing multiple animals with a high-resolution home-cage RFID system

Ochi, S.; Inada, H.; Osumi, N.

10.1101/2024.10.23.619967 — animal behavior and cognition — Posted on 2025-04-16

2701 A multicellular actin star network underpins epithelial organization and connectivity

Barai, A.; Soleilhac, M.; Xi, W.; Lin, S.-Z.; Karnat, M.; Bazellieres, E.; Richelme, S.; Lecouffe, B.; Chardes, C.; Berrebi, D.; Ruemmele, F.; Thery, M.; Rupprecht, J.-F.; Delacour, D.

10.1101/2024.07.26.605277 — cell biology — Posted on 2025-04-16

2702 Cytosine Methylation is a marker of Viral Gene Transfer across the eukaryotes

Sarre, L. A.; Gastellou Peralta, G. A.; Romero Charria, P.; Ovchinnikov, V.; de Mendoza, A.

10.1101/2025.04.15.648976 — genomics — Posted on 2025-04-16

2703 Short-term coastal forest responses to a hurricane-scale freshwater and saltwater flooding experiment

Myers-Pigg, A.; Hopple, A.; Pennington, S. C.; Regier, P.; Bond-Lamberty, B.; DiCianna, M. J.; Doro, K. O.; McDowell, N.; McElhinny, J.; Stearns, A.; Ward, N. D.; Bailey, V. L.; Megonigal, J. P.

10.1101/2025.04.13.648622 — ecology — Posted on 2025-04-15

2704 The FANCD2-FANCI heterodimer coordinates chromatin openness and cell cycle progression throughout DNA double-strand break repair.

Joyce, C. M.; Bacal, J.; Chowdhury, S. P.; Brown, A. N.; Wang, A. K.; Cruz, C.; Bains, K.; Rodriguez, Z. N.; McCormick, N. J.; Tzadikario, Y.; Tavasoli, K. U.; Gardner, B. M.; Richardson, C. D.

10.1101/2025.04.15.648866 — cell biology — Posted on 2025-04-16

2705 Metatranscriptomic Insights into Microbial Dynamics Prior to Disease Onset in Atlantic Salmon Aquaculture

Harding, A.; Diblasi, C.; Manousi, D.; Soung Kwak, J.; Hazlerigg, D. G.; Morkore, T.; Snippen, L. G.; de Leon, A. V.-P.; Saitou, M.

10.1101/2025.04.15.648526 — microbiology — Posted on 2025-04-15

2706 New high accuracy diagnostics for avian Aspergillus fumigatus infection using Nanopore methylation sequencing of host cell-free DNA and machine learning prediction

Drag, M. H.; Hvilsom, C.; Poulsen, L. L.; Jensen, H. E.; Tahas, S. A.; Leineweber, C.; Cray, C.; Bertelsen, M. F.; Bojesen, A. M.

10.1101/2025.04.11.648151 — microbiology — Posted on 2025-04-15

2707 Cell type-specific associations with Alzheimer's Disease conserved across racial and ethnic groups

Luquez, T.; Algoo, J.; Chiu, R.; Mares, J. A.; Yadav, A.; Lam, M.; Gaur, P.; Lai, X.; Lee, D. I.; Paryani, F.; Batchelor, R.; Belli, I.; Henry, J.; Mattison, C.; Starr, L.; De Jager, P. L.; Barnes, L. L.; Marquez, D. X.; Zhang, Y.; Bennett, D. A.; Menon, V.

10.1101/2025.04.14.648597 — neuroscience — Posted on 2025-04-15

2708 Molecular insights into early malignant transition of hepatocellular carcinoma

Hui, L.; Zhang, Z.; Li, H.; Chen, L.; Lu, T.; Shentu, X.; Liu, Y.; Ji, S.; Qiu, Z.; Zou, Y.; Wen, H.; Han, J.; Jiang, Z.; Fan, J.; Li, D.; Mesropian, A.; Pinyol, R.; Llovet, J. M.; Dong, H.; Ji, Y.

10.1101/2025.04.14.648739 — cancer biology — Posted on 2025-04-15

2709 Biometric Aging Clock for Practical Utility in Clinical Settings

Nayak, D.; Galkin, F.; Ghosh, S. K.

10.1101/2025.04.14.648594 — bioinformatics — Posted on 2025-04-15

2710 Sexual signal reliability in male zebra finches: Food intake explains the impact of immune activation on carotenoid-based coloration

Cantarero, A.; Mateo, R.; Camarero, P.; Andrade, P.; Carneiro, M.; Alonso-Alvarez, C.

10.1101/2025.04.08.647553 — evolutionary biology — Posted on 2025-04-15

2711 Human sand fly challenge elicits saliva-specific innate and TH1-polarized immunity that promotes Leishmania killing

Abdeladhim, M.; Teixeira, C.; Ressner, R.; Hummer, K.; Dey, R.; Gomes, R.; de Castro, W.; de Araujo, F. F.; Turiansky, G. W.; Iniguez, E.; Meneses, C.; Oliveira, F.; Aronson, N.; Lacsina, J. R.; Valenzuela, J. G.; Kamhawi, S.

10.1101/2025.02.25.640210 — immunology — Posted on 2025-04-15

2712 Energy calculations for atomic oxygen liberation from hypohalous acids biosynthesized by mammalian peroxidases

Puf, R.; Smith, M. L.; Laaksonen, A.

10.1101/2025.03.27.645784 — immunology — Posted on 2025-04-15

2713 Fluorescence-barcoded cell lines stably expressing membrane-anchored influenza neuraminidases

Finney, J.; Kuraoka, M.; Song, S.; Watanabe, A.; Liang, X.; Liao, D.; Moody, M. A.; Walter, E. B.; Harrison, S.; Kelsoe, G. H.

10.1101/2025.01.01.631020 — immunology — Posted on 2025-04-15

2714 Ethylene and ROS Signaling Are Key Regulators of Lateral Root Development under Salt Stress in Tomato

Rahmati Ishka, M.; Zhao, J.; Sussman, H.; Mohanty, D.; Craft, E.; Yu, L.; Pineros, M.; Tester, M.; Kawa, D.; Mittler, R.; Nelson, A.; Fei, Z.; Julkowska, M. M.

10.1101/2024.06.20.599848 — plant biology — Posted on 2025-04-15

2715 Animal product-free formation and cultivation of 3D primary hepatocyte spheroids

Mickols, E.; Primpas, L.; Oredsson, S.; Karlgren, M.

10.1101/2025.04.10.648088 — pharmacology and toxicology — Posted on 2025-04-15

2716 3D Tumor-Mimicking Phantom Models for Assessing NIR I/II Nanoparticles in Fluorescence-Guided Surgical Interventions

Harun, A.; Bendele, N.; Khalil, M. I.; Vasquez, I.; Djuanda, J.; Posey, R.; Rashid, H.; Christopher, G.; Bickel, U.; Gruev, V.; Tropp, J.; Egan, P.; Srivastava, I.

10.1101/2025.02.01.636085 — bioengineering — Posted on 2025-04-15

2717 Structural Heterogeneity of Proteoform-Ligand Complexes in AMP-Activated Protein Kinase Uncovered by Integrated Top-Down Mass Spectrometry

Chan, H.-J.; Krichel, B.; Bandura, L. J.; Chapman, E. A.; Rogers, H. T.; Fischer, M. S.; Roberts, D. S.; Gao, Z.; Wang, M.-D.; Wu, J.; Uetrecht, C.; Jin, S.; Ge, Y.

10.1101/2025.04.15.648965 — biochemistry — Posted on 2025-04-15

2718 ESBL plasmid compatibility with the surrounding microbial community influences ESBL gene survival under CRISPR-antimicrobial targeting

Given, C.; Jonsdottir, I.; Norvasuo, K.; Paananen, P.; Ruotsalainen, P.; Hiltunen, T.; Gunell, M.; Hakanen, A. J.; Jalasvuori, M.; Penttinen, R.

10.1101/2025.04.15.648872 — microbiology — Posted on 2025-04-15

2719 Reducing the impact of HaHV-1 in Australian abalone: the role of age and immune priming

Agius, J. R.; Ackerly, D.; Watson, A. C.; Smith, M. L.; Beddoe, T.; Helbig, K.

10.1101/2025.04.14.648835 — microbiology — Posted on 2025-04-15

2720 Biochemical characterization of the sole Leptospira interrogans diadenylate cyclase

Schuler, E.; Patel, D. T.; Marconi, R. T.

10.1101/2025.04.15.648992 — microbiology — Posted on 2025-04-15

2721 Reinforced CRISPR interference enables reliable multiplex gene repression in phylogenetically distant bacteria

Elmore, J. R.; Shrestha, R.; Wilson, A.; Francis, R.; Baldino, H.; Van Fossen, E. M.; Frank, A.; Stephenson, M.; Gupta, B.; Rivera, J.; Egbert, R.

10.1101/2025.04.14.648646 — microbiology — Posted on 2025-04-15

2722 Organics Guide Non-Classical Crystallization Of Bacterial Calcite Which Parallels Eukaryotic Biomineralization

Grosso Giordano, F.; Purino, M.; Boon, N.; De Belie, N.; Rodriguez-Navarro, C.

10.1101/2025.04.15.648918 — microbiology — Posted on 2025-04-15

2723 The accessory type III secretion system effectors shape intestinal inflammatory infection outcomes

Biswas, P.; Sanchez-Garrido, J.; Kozik, Z.; Mishra, V.; Ruano-Gallego, D.; Berkachy, R.; Jordan, S.; Wong, J. L. C.; Choudhary, J. S.; Frankel, G.

10.1101/2025.04.15.648969 — microbiology — Posted on 2025-04-15

2724 Engineering One-Signal Activated TILs with CD3-CD28 Chimeras for Potent Antitumor Activity in Solid Tumors

Wu, Y.; ye, x. s.; Zhu, Y.; Liu, S.; Yuan, Q.; Kong, D.; Zhao, L.

10.1101/2024.03.21.586203 — immunology — Posted on 2025-04-15

2725 Ontogeny of catechol-o-methyltransferase expression in the rat prefrontal cortex: effects of methamphetamine exposure

Carrica, L. K.; Gulley, J. M.

10.1101/2025.02.06.636913 — neuroscience — Posted on 2025-04-15

2726 Novel multi-transmitter calyx-like giant synapse revealed in the extended amygdala

Zhang, L.; Hernandez, V. S.; Giraldo, D. M.; Leon-Contreras, J. C.; Ye, R.; Zhang, S.; Schafer, M. K.-H.; Barrio, R. A.; Hernandez-Pando, R.; Ferraguti, F.; Eiden, L. E.

10.1101/2025.04.03.647119 — neuroscience — Posted on 2025-04-15

2727 Neural coding of multiple motion speeds in visual cortical area MT

Huang, X.; Ghimire, B.; Chakrala, A. S.; Wiesner, S.

10.1101/2023.04.08.532456 — neuroscience — Posted on 2025-04-15

2728 Super Recombinator (SuRe): An in vivo recombination system for scalable and efficient transgene assembly at a single genomic locus

Luo, J.; Huang, C.; Taylor, C. A.; Li, J.; Woo, S. J.; Yu, C.; Shen, K.; Schnitzer, M. J.

10.1101/2025.04.15.646138 — synthetic biology — Posted on 2025-04-15

2729 EVOFLOW-RNA: GENERATING AND REPRESENTING NON-CODING RNA WITH A LANGUAGE MODEL

Patel, S.; Peng, F. Z.; Fraser, K.; Friedman, A. D.; Chatterjee, P.; Yao, S.

10.1101/2025.02.25.639942 — synthetic biology — Posted on 2025-04-15

2730 T Cell Receptor Diversity, Cancer and Sex: Insights from 30,000 TCRβ Repertoires

Zahid, H. J.; Taniguchi, R.; Noceda, M. G.; Robbins, H.; Greissl, J.

10.1101/2024.10.21.619470 — cancer biology — Posted on 2025-04-15

2731 Impacts of Structural Properties of Myosin II Filaments on Force Generation

Ding, S.; Chou, P.-E.; Deguchi, S.; Kim, T.

10.1101/2024.11.12.623186 — biophysics — Posted on 2025-04-15

2732 Scrutinization on Docking Against Individually Generated Target Pockets for Each Ligand

Zhan, R.; Zhang, W.; Huang, J.

10.1101/2025.01.01.630989 — bioinformatics — Posted on 2025-04-15

2733 Diploid genome assembly of human fibroblast cell lines enables clone specific variant calling, improved read mapping and accurate phasing

Ranallo-Benavidez, T. R.; Hao, Y.; Volpe, E.; Jehangir, M.; Fukushima, N.; Mbegbu, O.; Reiman, R.; Molnar, J.; Murphy, D.; Paredes, D. M.; Wong, S.; Karaniuk, K.; Buchholtz, S.; Keats, J.; Machiela, M. J.; Kolmogorov, M.; Paten, B.; Giunta, S.; Barthel, F. P.

10.1101/2025.04.15.648829 — genomics — Posted on 2025-04-15

2734 Comparative gene annotation of 304 species of Drosophilidae

Dhakad, P.; Kim, B.; Petrov, D.; Obbard, D.

10.1101/2025.04.14.648771 — genomics — Posted on 2025-04-15

2735 Regulatory networks of KRAB zinc finger genes and transposable elements changed during human brain evolution and disease

Chen, Y.-C.; Maupas, A.; Nowick, K.

10.1101/2023.12.18.569574 — evolutionary biology — Posted on 2025-04-15

2736 A minimal mathematical model for polarity establishment and centralspindlin-independent cytokinesis

Maxian, O.; Longhini, K.; Glotzer, M.

10.1101/2024.08.07.607072 — cell biology — Posted on 2025-04-15

2737 Modulating NLRP3 splicing with antisense oligonucleotides to control pathological inflammation

Klein, R.; Onyuru, J.; Centa, J. L.; Viera, E. M.; Putnam, C. D.; Hoffman, H. M.; Hastings, M. L.

10.1101/2024.09.06.611206 — molecular biology — Posted on 2025-04-15

2738 ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei

Chen, Y.; Toufektchan, E.; Luan, X.; Hickling, J.; Norman, R. X.; Cifani, P.; Kentsis, A.; Zhou, W.; Maciejowski, J.

10.1101/2025.04.14.648782 — molecular biology — Posted on 2025-04-15

2739 DnaK interacting protein All4144 of Anabaena sp. PCC 7120: A thermo-sensor GrpE that acts as a nucleotide exchange factor and binds to DNA

Rai, L. C.; Sriwastaw, S.; Rai, R.

10.1101/2025.04.14.648684 — molecular biology — Posted on 2025-04-15

2740 Cas10 residues lining the target RNA binding channel regulate interference by distinguishing cognate target RNA from mismatched targets

Khweis, S. A.; Blackburn, M.; Pierce, M. O.; Lewis, C. R.; Dunkle, J. A.

10.1101/2025.04.15.649021 — molecular biology — Posted on 2025-04-15

2741 Structural basis for prohibitin-mediated regulation of mitochondrial m-AAA protease

Luo, D.; Zheng, L.; Lu, M.-A.; Chen, Z.; Guo, Q.; Gao, N.

10.1101/2025.04.15.648916 — molecular biology — Posted on 2025-04-15

2742 An Optimized FungaLight LIVE/DEAD Assay Quantifies Post-Stress and Antifungal-Treatment Survival in Diverse Yeasts Using Flow Cytometry

Tang, H.; Liang, J.; He, B. Z.

10.1101/2025.04.14.648826 — microbiology — Posted on 2025-04-15

2743 Identification and characterization of the surface layer protein AvsA in outer membrane vesicles, antibiotic resistance, and in vivo host colonization in Aeromonas veronii

Vieira Da Silva, C.; Arsenault, D.; Kramer-Earley, R.; Robinson, V. L.; Milligan-McClellan, K. C.; Graf, J.

10.1101/2025.04.15.648961 — microbiology — Posted on 2025-04-15

2744 Deciphering the RNA-based regulation mechanism of the phage-encoded AbiF system in Clostridioides difficile

Saunier, M.; Humbert, A.; Kreis, V.; Peltier, J.; Tisba, A.; Auxilien, S.; Blum, M.; Caldelari, I.; Lucier, J.-F.; Ueda, J.; Gautheret, D.; Toffano-Nioche, C.; Andreani, J.; Fortier, L.-C.; SOUTOURINA, O.

10.1101/2025.04.15.648962 — microbiology — Posted on 2025-04-15

2745 A non-invasive method for profiling the gut microbiome and virome of honey bee queens

Holmes, L. A.; Wolf Veiga, P.; Pettis, J.; Guarna, M. M.; Hoover, S. E.

10.1101/2025.04.15.648983 — microbiology — Posted on 2025-04-15

2746 pH-dependent beta-lactam resistance in Klebsiella pneumoniae is mediated by paralogous class B PBPs and the class A PBP, PBP1b.

Beagle, S.; Levin, P. A.

10.1101/2025.03.12.642896 — microbiology — Posted on 2025-04-15

2747 Expanding the chicken gut virome: Uncovering viral diversity, host interactions, and regional variations across the intestinal tract

Zhao, J.-X.; Ni, H.-B.; Nan, F.-L.; Yan, Q.; Li, S.; Su, J.-W.; Cai, Y.; Meng, J.-X.; Yu, H.-L.; Shang, K.-M.; Liu, R.; Hou, X.-W.; Elsheikha, H. M.; Ma, H.; Zhang, X.-X.

10.1101/2025.04.15.647674 — microbiology — Posted on 2025-04-15

2748 Contemporary seasonal human coronaviruses display differences in cellular tropism compared to laboratory-adapted reference strains

Gartner, M. J.; Smith, M. J.; Dapat, C.; Liaw, Y. W.; Tran, T.; Suryadinata, R.; Chen, J.; Sun, G.; Shepard, R. A.; Taiaroa, G.; Roche, M.; Lee, W. S.; Robinson, P.; Polo, J. M.; Subbarao, K.; Neil, J. A.

10.1101/2025.04.13.648626 — microbiology — Posted on 2025-04-15

2749 Integration of Nanomaterials and DBS to Improve Basal Ganglia Oscillations Using Delayed Van der Pol Model

Elfouly, M. A. A.

10.1101/2025.04.08.647898 — neuroscience — Posted on 2025-04-15

2750 Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors

Ozkan, A.; Padmanabhan, H. K.; Shipman, S.; Azim, E.; Kumar, P.; Sadegh, C.; Basak, N.; Macklis, J. D.

10.1101/2024.04.21.590488 — neuroscience — Posted on 2025-04-15

2751 A neural circuit basis for reward-induced suppression of fear generalization

Kong, M.-S.; Jo, Y. S.; Sethi, E.; Pyeon, G. H.; Zweifel, L. S.

10.1101/2024.09.05.611495 — neuroscience — Posted on 2025-04-15

2752 Alterations in the Ultrasonic Vocalization Sequences in pups of an autism spectrum disorder mouse model: A longitudinal study over age and sex

Agarwalla, S.; Selvarajan, Y.; Bandyopadhyay, S.

10.1101/2023.12.24.573249 — neuroscience — Posted on 2025-04-15

2753 How do brain regions specialised for concrete and abstract concepts align with functional brain networks? A neuroimaging meta-analysis

Hoffman, P.; Bair, M.

10.1101/2024.07.11.603079 — neuroscience — Posted on 2025-04-15

2754 Overnutrition directly impairs thyroid hormone biosynthesis and utilization, causing hypothyroidism, despite remarkable thyroidal adaptations

Rampy, J.; Torres-Manzo, A. P.; Hoffsmith, K.; Loberg, M. A.; Sheng, Q.; Salas-Lucia, F.; Bianco, A. C.; Arrojo e Drigo, R.; Wang, H.; Weiss, V. L.; Carrasco, N.

10.1101/2025.03.31.645596 — physiology — Posted on 2025-04-15

2755 The ribosome directs nascent chains through two folding-dependent pathways

Mitropoulou, A. N.; Wlodarski, T.; Streit, J. O.; Chan, S. H. S.; Plessa, E.; Woodburn, L. F.; Cabrita, L. D.; Christodoulou, J.

10.1101/2025.04.08.647855 — biophysics — Posted on 2025-04-15

2756 Covering All Bases: A Computational Method to Design Broad-spectrum T-cell-inducing Vaccines Applied to Betacoronaviruses

Palmer, P.; Fedosyuk, S.; Parthasarathy, S.; Holbrook, J.; George, C.; O'Reilly, L.; Wiegand, L.; Carnell, G. W.; Heeney, J. L.; Vishwanath, S.

10.1101/2025.04.14.648815 — bioinformatics — Posted on 2025-04-15

2757 Data-efficient protein mutational effect prediction with weak supervision by molecular simulation and protein language models

Deguchi, T.; Kurumida, Y.; Iida, S.; Kobayashi, K.; Saito, Y.

10.1101/2025.04.08.647800 — bioinformatics — Posted on 2025-04-15

2758 Engineering hematopoietic stem and progenitor cells to generate red blood cells as viral traps against HIV-1

Luna, S. E.; Feist, W. N.; Ben-Efraim, K.; Amorin, N. A.; Johnston, N. M.; Ghanim, H. Y.; Ekman, F. K.; Dudek, A. M.; Porteus, M. H.

10.1101/2025.04.14.648845 — bioengineering — Posted on 2025-04-15

2759 Design and validation of a new flat-sheet membrane bioreactor system for bioprocessing research requiring very low gas fluxes

Zhou, M.; Bello, I. O.; Magdalena, J. A.; Usack, J. G.

10.1101/2025.04.15.649005 — bioengineering — Posted on 2025-04-15

2760 An integrated and scalable rodent cage system enabling continuous computer vision-based behavioral analysis and AI-enhanced digital biomarker development

Robertson, T. L.; Ellis, M.; Bratcher-Petersen, N. A.; Ruidiaz, M. E.; Harada, K.; Toburen, D.; Oberhauser, J. P.; Grzenda, D.; Peltier, N.; Raza, M.; Benway, J.; Kiros, J.; Kumar, V.

10.1101/2024.12.18.629281 — animal behavior and cognition — Posted on 2025-04-15

2761 Global analysis of the cold-shock response in the model antibiotic producing actinomycete, Streptomyces coelicolor A3(2)

Evans, R. T.; Bucca, G.; Hesketh, A.; Smith, C. P.

10.1101/2025.04.11.648403 — genomics — Posted on 2025-04-15

2762 Reduced frequency of clonal hematopoiesis in Parkinson's disease

Sun, S.; Sproviero, D.; Payan-Gomez, C.; Huang, Z.; Hoeijmakers, J. H. J.; Maslov, A. Y.; Mastroberardino, P. G.; Vijg, J.

10.1101/2023.05.04.539397 — genetics — Posted on 2025-04-15

2763 Meteorins regulate the formation of the left-right organizer and the establishment of vertebrate body asymmetry

Eggeler, F.; Boulanger-Weill, J.; De Santis, F.; Belleri, L.; Duroure, K.; Auer, T. O.; Albadri, S.; Del Bene, F.

10.1101/2023.11.23.568438 — developmental biology — Posted on 2025-04-15

2764 RNA Editors Sculpt the Transcriptome During Terminal Erythropoiesis

Han, A.; Yermalovich, A.; Najia, M. A. T.; Pearson, D. S.; Fujiwara, Y.; Bolgov, M.; Kubaczka, C.; North, T. E.; Lundin, V.; Orkin, S.; Daley, G. Q.

10.1101/2025.04.03.647020 — developmental biology — Posted on 2025-04-15

2765 Mitotic spindle orientation and dynamics are fine-tuned by anisotropic tension via NuMA localisation

Tarannum, N.; Hargreaves, D.; Ilieva, D.; Goddard, G. K.; Jensen, O. E.; Woolner, S.

10.1101/2024.10.17.617436 — cell biology — Posted on 2025-04-15

2766 Role of Dengue in SARS-CoV-2 Evolution in Dengue Endemic Regions

Mallick, A.; Biswas, S.

10.1101/2025.04.13.648564 — microbiology — Posted on 2025-04-15

2767 Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 binding

Tse, A. L.; Lasso, G.; McLellan, J. S.; Chandran, K.; Miller, E. H.

10.1101/2025.04.14.648681 — microbiology — Posted on 2025-04-15

2768 Transferrin receptor 1 (TfR1) functions as an entry receptor for scale drop disease virus to invade host cell via clathrin-mediated endocytosis

Chen, J.; Yuting, F.; Li, Y.; Weng, S.; Wang, H.; He, J.; Dong, C.

10.1101/2025.04.15.648974 — microbiology — Posted on 2025-04-15

2769 Chromosomal resistance mutations facilitate acquisition of multidrug-resistance plasmids in Escherichia coli

Hanga, K.-S. N.; Brockhurst, M. A.; Bottery, M. J.

10.1101/2025.04.15.648949 — microbiology — Posted on 2025-04-15

2770 Organ-specific microbiomes in natural Lotus corniculatus populations: Metacommunity dynamics in the plant endosphere

Lutap, K.; Almario, J.; Mahmoudi, M.; Reis, F.; Bossdorf, O.; Kemen, E.

10.1101/2025.04.15.649008 — microbiology — Posted on 2025-04-15

2771 American black bear (Ursus americanus) as a potential host for Campylobacter jejuni

Parker, C. T.; Kathariou, S.; Miller, W. G.; Huynh, S.; Pascoe, B.; Cooper, K.

10.1101/2025.04.14.648838 — microbiology — Posted on 2025-04-15

2772 Mapping gene expression across the microbiome-gut-brain axis of germ- and specific pathogen-free mice

Dritsa, C.; Hoffmann, S.; Hulme, H.; Lynch, C.; Taylor, V.; Burchmore, R.; Cole, J.; Goodwin, R. J. A.; Wall, D. M.

10.1101/2025.04.15.648950 — microbiology — Posted on 2025-04-15

2773 The structure of a thermostable phage's Portal Vertex and Neck Complex illuminates its maturation process

Sedivy, E. L.; Agnello, E.; Hobaugh, J. E.; Ahsan, R.; Xu, C.; Song, K.; Kelch, B. A.

10.1101/2025.04.14.648768 — microbiology — Posted on 2025-04-15

2774 A Pan-Beta-Coronavirus Vaccine Bearing Conserved and Asymptomatic B- and T-Cell Epitopes Protect Against Highly Pathogenic Delta and Highly Transmissible Omicron SARS-CoV-2 Variants of Concern.

Vahed, H.; Prakash, S.; Quadiri, A.; Ibraim, I. C.; Omorogieva, E.; Patel, S. J.; Tadros, J. M.; Liao, E. J.; BENMOHAMED, L.

10.1101/2025.04.13.648648 — immunology — Posted on 2025-04-15

2775 Tempo-dependent selective enhancement of neural responses at the beat frequency can be mimicked by both an oscillator and an evoked model

Damsma, A.; de Roo, M.; Doelling, K.; Bazin, P.-L.; Bouwer, F. L.

10.1101/2024.07.11.603023 — neuroscience — Posted on 2025-04-15

2776 The Impact of Habitat Impermanence on Metapopulation Viability and Size

Walker, E. J.; Phillips, A. J.; Gilbert, B.

10.1101/2025.04.09.647889 — ecology — Posted on 2025-04-15

2777 Earlier snowmelt reduces the strength of carbon sink in montane meadows

Vought, O.; Kivlin, S.; Shulman, H.; Sorensen, P.; Inouye, D.; Ibanez, I.; Falb, P.; Rand, K.; Classen, A.

10.1101/2025.04.09.648035 — ecology — Posted on 2025-04-15

2778 Harnessing mRNA for the expression of monoclonal IgG and IgA in non-human primates.

Rouzeau, R.; Schmidt, H. R.; Deal, C.; Allen, J. D.; Dudley, D. M.; Burton, I.; Rakasz, E. G.; Plante, O.; Crispin, M.; Carfi, A.; Sok, D.

10.1101/2025.04.09.648023 — immunology — Posted on 2025-04-15

2779 Induction of Resident Memory CD8+T cell Phenotypes to Eliminate the HIV reservoir

Mancebo Perez, C.; Benitez Rodriguez, A.; Tsukalov, I.; Grau Exposito, J.; Castellvi, J.; Manalich Barrachina, L.; Suanzes, P.; Navarro, J.; Burgos, J.; Curran, A.; Centeno Mediavilla, C.; Falco, V.; Martin Gayo, E.; Buzon, M. J.; Genesca, M.

10.1101/2025.04.09.647906 — immunology — Posted on 2025-04-15

2780 Disturbing immune homeostasis by neutrophil loss of Uba1 induces VEXAS-like autoinflammatory disease in mice

Dong, G.; Liu, J.; Zhou, H.; Jin, W.; Wen, Y.; Wang, Z.; Xia, K.; Zhang, J.; Ma, L.; Ma, Y.; Cai, L. C.; Zhou, Q.; Wang, H.; Wei, W.; Fu, Y.; CAI, Z.

10.1101/2025.04.09.648068 — immunology — Posted on 2025-04-15

2781 It matters who you are: Biography modulates the neural dynamics of facial identity representation

Shi, Y.; Gommlich, S.; Kovacs, G.

10.1101/2025.04.08.647791 — neuroscience — Posted on 2025-04-15

2782 Alzheimer Disease: The proposed role of tanycytes in the formation of tau tangles and amyloid beta plaques in human brain

Fabian-Fine, R.; Roman, A. G.; Weaver, A. L.

10.1101/2025.04.08.647836 — neuroscience — Posted on 2025-04-15

2783 Unpacking similarity effects in visual memory search: categorical, semantic, and visual contributions

Shang, L.; Yeh, L.-C.; Zhao, Y.; Peelen, M. V.

10.1101/2025.04.09.647918 — neuroscience — Posted on 2025-04-15

2784 Brain Signal Variability During Rest as a Neural Mechanism Underlying Cognitive Reserve

Coors, A.; Stern, Y.; Habeck, C.

10.1101/2025.04.09.648011 — neuroscience — Posted on 2025-04-15

2785 The Maternal Effect of SKN-1B and DAF-7 on Intergenerational Pathogen Avoidance Learning in C. elegans.

Paisner, R.; Bekele, M.; Onyia, E.; Gordus, A. G.

10.1101/2025.04.14.648668 — neuroscience — Posted on 2025-04-15

2786 Design and optimization of a kinase-controlled allosteric switch

Cao, Q.; Toettcher, J. E.

10.1101/2025.04.15.648940 — synthetic biology — Posted on 2025-04-15

2787 Lost in a Large EEG Multiverse? Comparing Sampling Approaches for Representative Pipeline Selection

Short, C. A.; Hildebrandt, A.; Bosse, R.; Debener, S.; Oezyagcilar, M.; Paul, K.; Wacker, J.; Kristanto, D.

10.1101/2025.04.08.647779 — neuroscience — Posted on 2025-04-15

2788 A biGWAS strategy reveals the genetic architecture of the interaction between wheat and Blumeria graminis f. sp. tritici

Xie, J.; Luo, Q.; Wang, L.; Qiu, D.; Zhao, C.; Hu, J.; Zhang, J.; Zhao, X.; Chen, Z.; Wang, Y.; Yu, Y.; Luo, M.; Song, H.; Hou, Y.; Zhang, Z.; Yin, M.; Wang, H.; Li, X.; Fu, X.; Xiao, B.; Li, Y.; Wu, J.; Liu, W.; Wang, Y.; Zhu, M.; Zhang, Y.; Fernie, A. R.; Wang, W.; Li, H.; He, F.

10.1101/2025.04.09.647224 — genomics — Posted on 2025-04-15

2789 Fast and Memory-Efficient Dynamic Programming Approach for Large-Scale EHH-Based Selection Scans

Rahman, A.; Smith, T. Q.; Szpiech, Z. A.

10.1101/2025.04.09.647986 — genomics — Posted on 2025-04-15

2790 Neuronal titration of Snca via enhancer disruption mitigates disease onset in a Parkinson's disease mouse model

Boyd, R. J.; Kho, A. R.; McClymont, S.; Loftus, S. K.; Ko, H.; McCallion, A. S.

10.1101/2025.04.09.648026 — genetics — Posted on 2025-04-15

2791 The E3 ligase HECTD4 regulates COX-2 dependent tumor progression and metastasis

Vuille, J. A.; Tanriover, C.; Micalizzi, D. S.; Ebright, R. Y.; Animesh, S.; Morris, R.; Hajizadeh, S.; Nicholson, Z. J.; Russell, H. C.; Zaniewski, E. F.; Wittner, B. S.; Wesley, B. K.; Grunewald, J.; Szalay, R. N.; Antmen, E.; Fox, D. B.; Yang, M.; Joung, J. K.; Gulhan, D. C.; Elia, A. E. H.; Haas, W.; Oh, E.; Maheswaran, S.; Haber, D. A.

10.1101/2025.04.09.647907 — cancer biology — Posted on 2025-04-15

2792 Tumoral CD24 tunes platelets binding and pro-metastatic functions

Mittelheisser, V.; Liboni, C.; Mouriaux, C.; Trivigno, S. M. G.; Bochler, L.; Garcia-Leon, M.; Larnicol, A.; Paulen, L.; Stemmelen, T.; Mangin, P. H.; Lefebvre, O.; GOETZ, J. G.

10.1101/2025.04.09.648049 — cancer biology — Posted on 2025-04-15

2793 Brief Pulses of High-Level Fluid Shear Stress Enhance Metastatic Potential and Rapidly Alter the Metabolism of Cancer Cells.

Pope, A. N.; Moose, D. L.; Hudson, G. O.; Weresh, H. R.; Taylor, E. B.; Henry, M. D.

10.1101/2025.04.09.647247 — cancer biology — Posted on 2025-04-15

2794 Reducing food stress and parasitism may have unexpected consequences on faecal corticosterone in a wild rodent

Wolf, S. E.; Dluzniewska, O.; Babayan, S. A.; Pedersen, A. B.; Little, T. J.

10.1101/2025.04.09.647990 — evolutionary biology — Posted on 2025-04-15

2795 Identification of genetic variation associated with high-temperature tolerance in cowpea

Akakpo, R.; Lee, E. J.; Pacheco, J. B.; Rios, E.; Kantar, M. B.; Boukar, O.; Volz, K. M.; Akinmade, H.; Luis, G.; Boote, K. J.; Munoz-Amatriain, M.; Morrell, P. L.

10.1101/2025.04.09.647789 — evolutionary biology — Posted on 2025-04-15

2796 Rapid expansion of synaptic complexity as a key contributor to cognitive growth in early humans

Lepski, G.; Arevalo, A.; Silva de Camargo, P.; Nunes, K.; Barbosa Lemes, R.; Ferraz, T.; Strauss, A.; Miyagawa, S.

10.1101/2025.04.09.648028 — evolutionary biology — Posted on 2025-04-15

2797 SimMapNet: A Bayesian Framework for Gene Regulatory Network Inference Using Gene Ontology Similarities as External Hint

Shahdoust, M.; Aghdam, R.; Sadeghi, M.

10.1101/2025.04.09.647936 — bioinformatics — Posted on 2025-04-15

2798 High-Resolution Mapping of the Human E3-Substrate Interactome using Ubicon Uncovers Network Architecture and Cancer Vulnerabilities

Sakuma, T.; Otani, Y.; Shimizu, H.

10.1101/2025.04.09.647947 — bioinformatics — Posted on 2025-04-15

2799 Systematic contextual biases in SegmentNT relevant to all nucleotide transformer models

Ebbert, M. T. W.; Ho, A.; Dutch, B.; Page, M. L.; Byer, B. K.; Hankins, K. L.; Sabra, H.; Aguzzoli Heberle, B.; Wadsworth, M. E.; Fox, G. A.; Karki, B.; Hickey, C.; Fardo, D. W.; Bumgardner, C.; Jakubek, Y. A.; Steely, C. J.; Miller, J. B.

10.1101/2025.04.09.647946 — bioinformatics — Posted on 2025-04-15

2800 Deep genomic models of allele-specific measurements

Mostafavi, S.; Tue, X.; Sasse, A.; Chowdhary, K.; Spiro, A.; Wang, L.; Chikina, M.; Benoist, C.

10.1101/2025.04.09.648060 — bioinformatics — Posted on 2025-04-15

2801 Deconvoluting single-cell transcriptomics reveals cellular programs regulated by cell-cell communication in colorectal cancer

Zhang, H.; Lu, B.; Cooper, G. F.; Saeed, A.; Paisley, J. W.; Lu, X.; Chen, L.

10.1101/2025.04.09.648030 — bioinformatics — Posted on 2025-04-15

2802 DNA six-way junction conformations and their use in a 2D square lattice

Baten, A. J.; Mason, H. G.; Veneziano, R.; Bricker, W. P.

10.1101/2025.04.09.648031 — bioengineering — Posted on 2025-04-15

2803 Trophic Transfer of Perfluoroalkyl Acids in a Periphyton-Mayfly-Zebrafish Food Chain

Farrell, M. R.; Buchwalter, D. B.; Weed, R. A.; Enders, J. R.; Planchart, A.

10.1101/2025.04.09.647996 — ecology — Posted on 2025-04-15

2804 refineDLC: an advanced post-processing pipeline for DeepLabCut outputs

Klecel, W.; Rahael, H.; Brooks, S. A.

10.1101/2025.04.09.648046 — animal behavior and cognition — Posted on 2025-04-15

2805 The role of social-environmental factors on Procambarus clarkii dispersion capabilities

Oliveira, D. F.; Soares, M. S.; Anastacio, P.; Banha, F.

10.1101/2025.04.09.647993 — animal behavior and cognition — Posted on 2025-04-15

2806 Characterization of a high-intensity band that cross-reacts with FLAG-M2 antibodies in immunoblots in a subset of laboratory strains of Saccharomyces cerevisiae.

Reid, N. K.; Liang, A. C.; Duncan, M. C.

10.1101/2025.04.15.648968 — cell biology — Posted on 2025-04-15

2807 CLOOSE: An open-source platform for optical closed-loop experiments

Francioni, V.; Beltramini, A.; Fan, L. Z.; Harnett, M. T.

10.1101/2025.04.09.648061 — neuroscience — Posted on 2025-04-15

2808 Superior colliculus coordinates whole-brain dynamics for sudden unconscious visual insight

Murata, T.; Kunishige, K.; Seno, S.; Ohzawa, I.; Kaneko, K.; Yanagida, T.; Haruno, M.; Hosoda, K.

10.1101/2025.04.09.648050 — neuroscience — Posted on 2025-04-15

2809 Suzetrigine (VX-548) exhibits activity-dependent effects on human dorsal root ganglion neurons

Uhelski, M. L.; Schaub, M. K.; Espinosa, F.; Heles, M.; Cortes-Mejia, N. A.; Li, Y.; Tatsui, C. E.; Rhines, L. D.; Alvarez-Breckendridge, C.; Funk, G.; Horton, P.; Cervantes, A.; Lesnak, J. B.; Curatolo, M.; Dussor, G.; Price, T. J.; Dougherty, P. M. M.

10.1101/2025.04.09.648014 — neuroscience — Posted on 2025-04-15

2810 Amyloid fibrils in Alzheimer's disease differently modulate sleep and cortical oscillations in mice depending on the type of amyloid

Sanagi, T.; Okumura, M.; Lin, Y.; Kanemura, S.; Moon, E.; Heo, Y.; Takahara, K.; Tsunematsu, T.; Lee, Y.-H.

10.1101/2025.04.09.647928 — neuroscience — Posted on 2025-04-15

2811 Multi-Metric Quantitative MRI Identifies Spatially Distinct Age-Related Brain Differences in Female Bonnet Macaques

Dieckhaus, L.; McDermott, K.; Galons, J.-P.; Barnes, C. A.; Hutchinson, E. B.

10.1101/2025.04.09.648008 — neuroscience — Posted on 2025-04-15

2812 The deubiquitinase OTULIN regulates tau expression and RNA metabolism in neurons

Tangavelou, K.; Bondu, V.; Li, M.; Li, W.; Liao, F.-F.; Bhaskar, K.

10.1101/2025.04.09.648063 — neuroscience — Posted on 2025-04-15

2813 Cultures of Tyrophagus putrescentiae experimentally infected with Cardinium and Wolbachia presented reduced fitness

Hubert, J.; Glowska-Patyniak, E.; Pekar, S.

10.1101/2025.04.09.647973 — zoology — Posted on 2025-04-15

2814 Spatial Adaptation of Primate Retinal Ganglion Cells between Artificial and Natural Stimuli

Vystrcilova, M.; Sridhar, S.; Burg, M. F.; Khani, M. H.; Karamanlis, D.; Schreyer, H. M.; Ramakrishna, V.; Krüppel, S.; Zapp, S. J.; Mietsch, M.; Gollisch, T.; Ecker, A. S.

10.1101/2025.04.09.647910 — systems biology — Posted on 2025-04-15

2815 GEMsembler: cross-tool structural comparison and ensemble modeling improve metabolic model performance

Matveishina, E. K.; Bartmanski, B. J.; Benito-Vaquerizo, S.; Zimmermann-Kogadeeva, M.

10.1101/2025.04.09.647174 — systems biology — Posted on 2025-04-15

2816 A knowledge graph and topological data analysis framework to disentangle the tomato-multi pathogens complex gene regulatory network

multari, m.; carriere, m.; Amoros-Gabarron, x.; damy, a.; lobentanzer, s.; saez-rodriguez, J.; Jaubert, S.; Dugourd, A.; BOTTINI, S.

10.1101/2025.04.09.647963 — systems biology — Posted on 2025-04-15

2817 Exercise-Induced Myostimulin Enhances Muscle Function in Health and Disease

Hillger, F.; Keller, H.; Furrer, A.; Melly, S.; Boesch, J.; Seddik, S.; Pierrel, E.; Bello, F.; Scharenberg, M.; Leber, X.; Hug, C.; Vicart, A.; Greiner, G.; Meyer, A.; Cobos-Correa, A.; Kaufmann, M.; Aschenbrenner, D.; Allard, C.; Delucis-Bronn, C.; Killmer, S.; Hils, L.; Rothen, J.; Lemire, S.; Altorfer, M.; Lambert, C.; Doelemeyer, A.; Accart, N.; Bepperling, A.; Weiss, L.; Burget, A.; Couttet, P.; Parker, C. N.; Rooks, D.; Kneissel, M.; Summermatter, S.

10.1101/2025.04.09.647960 — physiology — Posted on 2025-04-15

2818 Accelerated plastic aging in suspension (APAS): A simple, reproducible approach for the generation of model micro- and nanoplastics through simulated environmental forces

Lelliott, P. M.; Lindley, M.; Vidallon, M.; Hobro, A.; Eliason, A. D.; Moreno-Caceres, S.; Samandra, S.; Harrison, T.; Harper, R.; Trepout, S.; Devineau, S.; Clarke, B.; Smith, N. I.; Wang, X.; Marciano, D.; Pinto, A. R.

10.1101/2025.04.09.647903 — pharmacology and toxicology — Posted on 2025-04-15

2819 ArcDFI: Attention Regularization guided by CYP450 Interactions for Predicting Drug-Food Interactions

Gim, M.; Kang, J.; Park, D.; Jeon, M.

10.1101/2025.04.09.647981 — pharmacology and toxicology — Posted on 2025-04-15

2820 An inducible genetic model of chronic hypoxic signaling in cardiomyocytes precipitates severe cardiomyopathy and remodeling.

Phillips, C. M.; Zeitz, M. J.; Sapp, E. H.; Abouelenein, K. M.; Smyth, J. W.

10.1101/2025.04.09.647295 — pathology — Posted on 2025-04-15

2821 Early Flowering 3 (ELF3) inhibits hypocotyl phototropism in light-grown Arabidopsis seedlings.

Cobb, G.; Krahmer, J.; Nawkar, G. M.; Boccaccini, A.; Fankhauser, C.

10.1101/2025.04.09.647958 — plant biology — Posted on 2025-04-15

2822 Insights on Chamelea gallina growth dynamics from the Holocene climate optimum in the Northern Adriatic Sea (Italy)

Cheli, A.; Mancuso, A.; Prada, F.; Rojas, A.; Falini, G.; Goffredo, S.; Scarponi, D.

10.1101/2025.04.09.647857 — paleontology — Posted on 2025-04-15

2823 Proteomic Remodeling During Tumor Cell-Induced Platelet Aggregation Unveils Metastatic Drivers in Colorectal Cancer

Sauer, T.; Gruner, C.; Kern, K.; Rackisch, A.; Tischner, L.; Schulz, K.; Ostermann, J.; Cohrs, L.; Kohl, M.; Verschoor, A.; Gemoll, T.

10.1101/2025.04.09.647951 — cancer biology — Posted on 2025-04-15

2824 Mosaic accumulation of somatic genetic variation and estimates of age in the long-lived reef-building coral Acropora palmata

Conn, T.; Renton, J.; Chamberland, V.; Dellaert, Z.; Werner, B.; Reusch, T. B. H.; Baums, I.

10.1101/2025.04.11.641527 — genomics — Posted on 2025-04-15

2825 The role of mating systems in postzygotic reproductive isolation between two recently divergent Aquilegia Species

Ma, Y.; Peng, J.; Weng, Y.; Li, H.; Zhang, Z.-Q.

10.1101/2025.04.09.647901 — evolutionary biology — Posted on 2025-04-15

2826 Sign epistasis extends the effects of balancing selection on genetic diversity

Khudiakova, K. A.; Barton, N. H.; Arnqvist, G.

10.1101/2025.04.09.647826 — evolutionary biology — Posted on 2025-04-15

2827 Wnt/β-catenin signalling assists cell fate decision making in the early mouse embryo

Lilao-Garzon, J.; Corujo-Simon, E.; Vinyoles, M.; Fischer, S. C.; Guillen, J.; Balayo, T.; Munoz-Descalzo, S.

10.1101/2025.04.09.647220 — developmental biology — Posted on 2025-04-15

2828 Cranial suture integrity is maintained by Fgfr3 in zebrafish

Pereur, R.; Marc, Y.; Lim, Y.; Schmitt, A.; Malbouyres, M.; Chessel, A.; Ruggiero, F.; Schanne-Klein, M.-C.; Legeai-Mallet, L.; Dambroise, E.

10.1101/2025.04.09.647929 — developmental biology — Posted on 2025-04-15

2829 Decoding stimulus-specific regulation of promoter activity of p53 target genes

Vigliotti, F.; Engelmann, N.; Sinzger-DAngelo, M.; Koeppl, H.; Loewer, A.

10.1101/2025.04.09.647556 — systems biology — Posted on 2025-04-15

2830 A simple, fast and cost-efficient protocol for ultra-sensitive ribosome profiling

Koubek, J.; Jetzinger, K.; Dror, S.; Irastortza-Olaziregi, M.; Frank, D.; Kotan, I.; Santos, J.; Tippmann, F.; Lafrenz, P.; Kaessmann, H.; Amster-Choder, O.; Bukau, B.; Kramer, G.

10.1101/2025.04.09.647970 — systems biology — Posted on 2025-04-15

2831 Quantifying replication stress in cancer without proliferation confounding

Jungk, P.; Kschischo, M.

10.1101/2025.04.10.648133 — cancer biology — Posted on 2025-04-15

2832 Chemical inhibition of RPA gap protection sensitizes BRCA1-deficient cancers to PARP inhibition

VanderVere-Carozza, P. S.; Jordan, M. R.; Garrett, J. E.; Pollok, K. E.; Hinshaw, H. D.; Sulaiman, X.; Liu, S.; Wan, J.; Pawelczak, K. S.; Turchi, J. J.

10.1101/2025.04.09.647957 — cancer biology — Posted on 2025-04-15

2833 Male XIST expression in cardiac pseudo-glia does not induce X chromosome inactivation

Gorin, G.; Goodman, L.

10.1101/2025.04.09.648005 — bioinformatics — Posted on 2025-04-15

2834 RNAchat: Integrating machine learning algorithms to identify metapathways based on clinical and multi-omics data

Tang, M.

10.1101/2025.04.02.646761 — bioinformatics — Posted on 2025-04-15

2835 Taming Darwin's conundrum: On the role of phylogenetic and functional differentiation in plant naturalization on oceanic islands

Arjona, Y.; Jay-Garcia, L. S.; Reyes-Betancort, J. A.; Morente-Lopez, J.; Salas-Pascual, M.; Naranjo-Cigala, A.; Sicilia-Pasos, G.; Padron-Mederos, M. A.; Orihuela-Rivero, R.; Gonzalez-Montelongo, R.; Patino, J.

10.1101/2025.04.09.648018 — ecology — Posted on 2025-04-15

2836 A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the Drosophila Ventral Nerve Cord.

Soffers, J. H.; Beck, E.; Sytkowski, D. J.; Maughan, M. E.; Devarakonda, D.; Zhu, Y.; Wilson, B.; David Chen, Y.-C.; Erclik, T.; Truman, J.; Skeath, J.; Lacin, H.

10.1101/2024.11.27.625713 — developmental biology — Posted on 2025-04-15

2837 Immunological characterization of peritoneal exudate cells in liver cirrhosis patients

Kaji, S.; Sasaki, I.; Kunimoto, S.; Wakaki-Nishiyama, N.; Tosuji, E.; Kurara, A.; Kato, T.; Mutsukawa, C.; Okuzaki, D.; Okamoto, C.; Yamano, Y.; Shimizu, R.; Maeshima, S.; Ida, Y.; Yamashita, Y.; Hashimoto, T.; Iwabuchi, S.; Hashimoto, S.; Saitoh, S.-I.; Araki, S.-i.; Kitano, M.; Kaisho, T.

10.1101/2025.02.19.638957 — immunology — Posted on 2025-04-15

2838 Zebrafish optic nerve injury results in systemic retinal ganglion cell dedifferentiation

Ali, A.; Schriever, H.; Kostka, D.; Kuwajima, T.; Koenig, K.; Gross, J.

10.1101/2025.04.09.646875 — neuroscience — Posted on 2025-04-15

2839 FL/FLT3 signaling enhances mechanical pain hypersensitivity through Interleukin-1 beta (IL-1β) in male mice

Sonrier, C.; Sar, C.; Melo, I.; Diouloufet, L.; Lucena-Silva, G. V.; Mallie, S.; Bertin, J.; Leyris, J.-P.; Ango, F.; Cunha, T. M.; Moha ou Maati, H.; Valmier, J.; Rivat, C.; Mechaly, I.

10.1101/2025.04.09.648037 — neuroscience — Posted on 2025-04-15

2840 Nucleus raphe magnus serotonin neurons bidirectionally control spinal mechanical pain transmission

Grivet, Z.; Verboven, A.; Aby, F.; Benazzouz, R. B.; Dhellemmes, T.; Perrot, E.; Beyeler, A.; Heisler, L. K.; Balia, M.; Battefeld, A.; martin, h.; Fioramonti, X.; Landry, M.; De Koninck, Y.; Benazzouz, A.; Fossat, P.

10.1101/2025.04.09.647804 — neuroscience — Posted on 2025-04-15

2841 Advection versus diffusion in brain ventricular transport

Herlyng, H.; Ellingsrud, A. J.; Kuchta, M.; Jeong, I.; Rognes, M. E.; Jurisch-Yaksi, N.

10.1101/2025.04.15.648743 — neuroscience — Posted on 2025-04-15

2842 Sex-specific metabolic responses to modulation of the glucagon-FGF21 axis in female mice

Merrild, C.; Johansen, V. B. I.; Clemmensen, C.; Ranea-Robles, P.

10.1101/2025.04.09.647697 — physiology — Posted on 2025-04-15

2843 Sevoflurane inhibition of the developmentally expressed neuronal sodium channel Nav1.3

Xiang, J.; Herold, K. F.; Platholi, J.; Hemmings, H. C.

10.1101/2025.04.10.648240 — pharmacology and toxicology — Posted on 2025-04-15

2844 Splice-switching ASOs targeting an Alu-derived exon in the AURKA 5'UTR collapse an SRSF1-AURKA-MYC oncogenic circuit in pancreatic cancer

Kral, A. J.; Jia, L.; Sim, G.; Wan, L.; Krainer, A. R.

10.1101/2025.04.14.648775 — cancer biology — Posted on 2025-04-15

2845 The carnosinase dipeptidase CNDP1 is a novel metabolic vulnerability in brain metastasis

Gomez-Munoz, M. A.; Karz, A.; Navarro, M.; Osorio-Vasquez, V. M.; Katsara, O.; Walker, A.; Berico, P.; Medellin, A. P.; Eskow, N. M.; Wan, Y.; Ibrahim, M.; Tagore, S.; DSouza, E. K.; Izar, B.; Vega-Saenz de Miera, E.; Osman, I.; Pacold, M.; Kong, X.; Levesque, M.; Possemato, R.; Holmen, S.; Schneider, R.; Vincent, T.; Ruggles, K.; Biancur, D.; Hernando, E.

10.1101/2025.03.18.644053 — cancer biology — Posted on 2025-04-15

2846 An intrinsically disordered region mediates RNA-binding selectivity and pro-oncogenic activities of LARP6

Capraro, F.; Abis, G.; Incocciati, A.; Karimzadeh, M.; Masino, L.; Barley, A.; Bui, T. T. T.; Kelly, G.; Goodarzi, H.; Conte, M. R.; Mardakheh, F. K.

10.1101/2024.09.20.614075 — biochemistry — Posted on 2025-04-15

2847 Long-term live imaging, cell identification and cell tracking in regenerating crustacean legs

Cevrim, C.; Laplace-Builhe, B.; Sugawara, K.; Rusciano, M. L.; Labert, N.; Brocard, J.; Almazan, A.; Averof, M.

10.1101/2024.09.11.612529 — developmental biology — Posted on 2025-04-15

2848 How and when can environmental influences change cerebral cortex? An experimental training study of twins with birth weight differences

Walhovd, K. B.; Brathen, A. C. S.; Overbye, K.; Kransberg, J.; Sorensen, O.; Garrido, P. F.; Amlien, I. K.; Alatrorre-Warren, J.-L.; Mowinckel, A. M.; Falch, E. S.; Slivka, M.; Czajkowski, N. O.; Wang, Y.; Due-Tonnessen, P.; Harris, J. R.; Vidal-Pineiro, D.; Fjell, A.; Sneve, M. H.

10.1101/2025.03.06.641380 — neuroscience — Posted on 2025-04-15

2849 Beyond beta rhythms: Aperiodic broadband power reflects Parkinson's disease severity - a multicenter study

Gerster, M.; Waterstraat, G.; Binns, T. S.; Darcy, N.; Wiest, C.; Koehler, R. M.; Vanhoecke, J.; West, T. O.; Sure, M.; Todorov, D.; Radzinski, L.; Habets, J. G.; Busch, J. L.; Feldmann, L.; Krause, P.; Faust, K.; Schneider, G.-H.; Ashkan, K.; Pereira, E.; Akram, H.; Zrinzo, L.; Blankertz, B.; Villringer, A.; Tan, H.; Hirschmann, J.; Kuehn, A. A.; Florin, E.; Schnitzler, A.; Oswal, A.; Litvak, V.; Neumann, W.-J.; Curio, G.; Nikulin, V.

10.1101/2025.03.11.642600 — neuroscience — Posted on 2025-04-15

2850 Differential interfacial tension between oncogenic and wild-type populations forms the mechanical basis of tissue-specific oncogenesis in epithelia

Datta, A.; Dewan, P.; Anto, A.; Chhabra, T.; Tejaswi, T.; Muthukrishnan, S.; Rao, A.; Sarkar, S.; Vishwakarma, M.

10.1101/2025.03.14.643229 — biophysics — Posted on 2025-04-15

2851 ganon2: up-to-date and scalable metagenomics analysis

Piro, V. C.; Reinert, K.

10.1101/2023.12.07.570547 — bioinformatics — Posted on 2025-04-15

2852 Rewriting nuclear epigenetic scripts in mitochondrial diseases as a strategy for heteroplasmy control

Perez, M. J.; Colombo, R. B.; Real, S. M.; Branham, M. T.; Laurito, S. R.; Moraes, C. T.; Mayorga, L.

10.1101/2024.12.30.630791 — genomics — Posted on 2025-04-15

2853 Mixed evidence for species diversity affecting ecological forecasts in constant versus declining light

Limberger, R.; Daugaard, U.; Choffat, Y.; Gupta, A.; Jelic, M.; Jyrkinen, S.; Krug, R. M.; Nohl, S.; Pennekamp, F.; van Moorsel, S. J.; Zheng, X.; Zuppinger-Dingley, D.; Petchey, O. L.

10.1101/2024.04.30.591860 — ecology — Posted on 2025-04-15

2854 Phage Steering in the Presence of a Competing Bacterial Pathogen

Czerwinski, S. M.; Gurney, J.

10.1101/2024.09.28.615603 — microbiology — Posted on 2025-04-15

2855 Modulating AP-1 enables CAR-T cells to establish an intratumoral PD-1+Tcf1+ stem-like reservoir and overcomes resistance to PD-1 axis blockade

Snyder, A. J.; Shasha, C.; Ho, T.; Garrison, S.; Wilhelm, A. R.; Kluesner, M. G.; Ortiz, S.; Nutt, W. S.; Bingham, E.; Bhise, S. S.; Fan, E.; Zepeda, V.; Sarvothama, M.; Wang, X.; Potluri, S.; Long, A.; Elz, A.; Furlan, S.; Newell, E. W.; Srivastava, S.

10.1101/2025.04.10.648245 — immunology — Posted on 2025-04-15

2856 Depth-resolved fiber photometry of amyloid plaque signals in freely behaving Alzheimer's disease mice

Byron, N.; McAlinden, N.; Pisano, F.; Pisanello, M.; Ferreira, J.; Montinaro, C.; Mathieson, K.; De Vittorio, M.; Pisanello, F.; Sakata, S.

10.1101/2025.04.08.647900 — neuroscience — Posted on 2025-04-15

2857 WITHDRAWN: Intrinsic Opening of BK Channels Derives from Inherent Leakage in Hydrophobic Gating

Jia, Z.; Zhang, G.; Shi, J.; Cui, J.; Chen, J.

10.1101/2025.01.13.632877 — biophysics — Posted on 2025-04-15

2858 Multiple cis-regulatory elements collaborate to control mdka expression in zebrafish adult telencephalic neural stem cells during constitutive and regenerative neurogenesis

Chen, J.; Hendriks, A.; Takamiya, M.; Beil, T.; Diotel, N.; Rastegar, S.

10.1101/2025.04.09.647643 — developmental biology — Posted on 2025-04-15

2859 Targeting CRM1-HMGB1 Nuclear Translocation in Type 2 Diabetes-Driven Metabolic Dysfunction Associated Steatotic Liver Disease

Paramasivam, P.; Bravo, G. M.; Coffman, B. B.; Rajaiya, J.; Monga, S. P.; Alvidrez, R. I. M.

10.1101/2025.04.09.648024 — pathology — Posted on 2025-04-15

2860 Fractionated radiation alters the extracellular matrix produced by muscle-invasive bladder cancer cells

Guerrero Quiles, C.; Fahy, S.; Bartak, M.; Gonzalez A., J.; Powell, E.; Reed, R.; Reeves, K.; Baker, A.; Hoskin, P.; James, N. D.; Hall, E.; Huddart, R. A.; Porta, N.; West, C.; Biolatti, V.; Choudhury, A.

10.1101/2025.04.08.647735 — cancer biology — Posted on 2025-04-15

2861 A Dual-Action Liposome-Peptide Formulation Synergistically Counteracts A Gain-of-Function p53 Mutant

Ghosh Chaudhary, S.; Bhowmick, S.; Bhattacharya, S.; Roy, S.; Ali, N.

10.1101/2025.04.09.647913 — cancer biology — Posted on 2025-04-15

2862 BINSEQ: A Family of High-Performance Binary Formats for Nucleotide Sequences

Teyssier, N.; Dobin, A.

10.1101/2025.04.08.647863 — bioinformatics — Posted on 2025-04-15

2863 CellLoop: Identifying single-cell 3D genome chromatin loops

Ye, Y.; Hu, Y.; Zhang, S.; Chen, H.; Gao, L.

10.1101/2025.04.08.647893 — bioinformatics — Posted on 2025-04-15

2864 Spatial Transcriptomics Using Archived Formalin-Fixed Paraffin-Embedded Core Needle Biopsy Tissues Revealed Unique Transcriptomic Signatures in Kidney Transplant Rejections

Wongworawat, Y. C.; Nepal, C.; Duhon, M.; Chen, W.; Nguyen, M.-T.; Godzik, A.; Qiu, X.; Li, V. W.; Yu, G.; Villicana, R.; Zuppan, C.; De Vera, M.; Haas, M.; Wang, C.

10.1101/2025.04.08.647600 — immunology — Posted on 2025-04-15

2865 Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer's disease and epilepsy

Li, H.; Xie, Z.; Tian, Y.; Yang, Y.; Lin, B.; Chen, S.; Li, J.; Wu, J.; Chen, M.; Liu, X.; Sun, Y.; Deng, Z.; Hong, M.; Huang, B.; Wei, N.; Ji, X.

10.1101/2024.10.28.618752 — systems biology — Posted on 2025-04-15

2866 Hepatic isomiR landscaping reveals new biological insights into metabolic dysfunction in steatotic liver disease

Brion, C.; Hoang, S. A.; Wang, G.; Mirshahi, F.; Ang, J.; Long, M. R.; Zhu, Z.; Sakhamuri, B.; Srour, M. A.; Siddiqui, M. S.; Asgharpour, A.; Hayes, D. J.; Foster, N. C.; Salzman, D. W.; Sanyal, A. J.

10.1101/2025.04.08.647685 — bioinformatics — Posted on 2025-04-15

2867 ANOMALY: A Snakemake pipeline for identifying NuMTs from Long-Read Sequencing Data

Mahar, N. S.; Singh, R.; Gupta, I.; Ramdas, S.

10.1101/2025.04.08.647704 — bioinformatics — Posted on 2025-04-15

2868 FLASH-MM: fast and scalable single-cell differential expression analysis using linear mixed-effects models

Xu, C.; Pouyabahar, D.; Voisin, V.; Heydari, H.; Bader, G.

10.1101/2025.04.08.647860 — bioinformatics — Posted on 2025-04-15

2869 Circuit Mining in Transcriptomics Data

Peherstorfer, T.; Ulonska, S.; Burger, B.; Lucato, S.; Al-Hamdan, B.; Kleinlehner, M.; Andlauer, T. F. M.; Bühler, K.

10.1101/2025.04.09.647750 — bioinformatics — Posted on 2025-04-15

2870 Complex genetic determinism of male-fertility restoration in the gynodioecious snail Physa acuta

Skarlou, E.; Laugier, F.; Bethune, K.; Chenin, T.; Donnay, J.-M.; Froissard, C.; David, P.

10.1101/2024.08.08.607164 — evolutionary biology — Posted on 2025-04-15

2871 Heterogeneity of radial spokes structural components and associated enzymes in Tetrahymena cilia

Bicka, M.; Ghanaeian, A.; Black, C.; Joachimiak, E.; Osinka, A.; Majhi, S.; Konopka, A.; Bulska, E.; Bui, K. H.; Wloga, D.

10.1101/2023.08.11.551218 — cell biology — Posted on 2025-04-15

2872 Sulfoquinovose is exclusively metabolized by the gut microbiota and degraded differently in mice and humans

Krasenbrink, J.; Hanson, B. T.; Weiss, A. S.; Borusak, S.; Tanabe, T. S.; Lang, M.; Aichinger, G.; Hausmann, B.; Berry, D.; Richter, A.; Marko, D.; Mussmann, M.; Schleheck, D.; Stecher, B.; Loy, A.

10.1101/2025.01.22.634256 — microbiology — Posted on 2025-04-15

2873 Effects of Combination Therapy of a CDK4/6 and MEK Inhibitor in Diffuse Midline Glioma Preclinical Models

Tomita, Y.; Link, G.; Ge, Y.; Gold, E. R. H.; Cardona, H. J.; Romero, M.; Gadd, S.; Watanabe, J.; Uchida, E.; Hashizume, R.; Takata, N.; Pinero, G.; Hambardzumyan, D.; Spasojevic, I.; Hu, G.; Hennika, T.; Brat, D. J.; Green, A.; Becher, O. J.

10.1101/2025.04.08.647742 — cancer biology — Posted on 2025-04-15

2874 Harnessing AlphaFold to reveal hERG channel conformational state secrets

Ngo, K.; Yang, P.-C.; Yarov-Yarovoy, V.; Clancy, C. E.; Vorobyov, I.

10.1101/2024.01.27.577468 — biophysics — Posted on 2025-04-15

2875 Martini 3 protein models - a practical introduction to different structure bias models and their comparison

Duve, T.; Wang, L.; Borges-Araujo, L.; Marrink, S.-J.; Souza, P. C. T.; Thallmair, S.

10.1101/2025.03.17.643608 — biophysics — Posted on 2025-04-15

2876 Comparison and Optimization of Cellular Neighbor Preference Methods for Quantitative Tissue Analysis

Schiller, C.; Ibarra-Arellano, M. A.; Bestak, K.; Tanevski, J.; Schapiro, D.

10.1101/2025.03.31.646289 — bioinformatics — Posted on 2025-04-15

2877 AI-Driven System for Large-Scale Automated Collection of Mouse Profile Images

Ozawa, N.; Sakai, Y.; Sakai, Y.; Koshimoto, C.; Shiozawa, S.

10.1101/2025.03.27.645835 — animal behavior and cognition — Posted on 2025-04-15

2878 Genome organization by SATB1 binding to base-unpairing regions (BURs) provides scaffold for SATB1-regulated gene expression

Kohwi, Y.; Wong, X.; Grange, M.; Sexton, T.; Richards, H. W.; Kitagawa, Y.; Sakaguchi, S.; Liang, Y.-C.; Chuong, C.-M.; Botchkarev, V.; Taniuchi, I.; Reddy, K. L.; Kohwi-Shigematsu, T.

10.1101/2021.12.19.473323 — genomics — Posted on 2025-04-15

2879 Shallow-water chemosymbiotic clams are a globally significant and previously overlooked carbon sink

Li, M.; Li, Y.; Mao, S.; Zhang, Z.; Chen, C.; Nie, X.; Liu, X.; Wang, H.; Liu, X.; Zhang, W.; Lin, Q.; Zhuang, G.-C.; Sun, J.

10.1101/2024.02.25.581922 — microbiology — Posted on 2025-04-15

2880 SARS-CoV-2 spike antibodies cross-react with dengue virus and enhance infection in vitro and in vivo

Jakhar, K.; Sonar, S.; Singh, G.; Asuru, T. R.; Joshi, G.; Beniwal, N.; Sarkar, T.; Tiwari, M.; Kaur, J.; Rathore, D. K.; Lal, B.; Kumar, S.; Srivastav, P.; Kumar, S.; Phagna, V.; Mithina, S.; Kumar, L.; Gupta, V.; Kshetrapal, P.; Singh, S.; Wadhwa, N.; Thiruvengadam, R.; Raghavan, S.; Gosain, M.; Shrivastava, T.; Bhattacharyya, S.; Asthana, S.; Guchhait, P.; Mani, S.

10.1101/2023.10.09.557914 — immunology — Posted on 2025-04-15

2881 A microbial metabolite protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration

Goettert, S.; Thiele-Orberg, E.; Fan, K.; Heinrich, P.; Matthe, D.; Khalid, O.; Klostermeier, L.; Suriano, C.; Strieder, N.; Gebhard, C.; Vonbrunn, E.; Mamilos, A.; Hirsch, D.; Meedt, E.; Kleigrewe, K.; Hiergeist, A.; Glaesner, J.; Ghimire, S.; Joachim, L.; Voll, F.; Neuhaus, K.; Perl, M.; Pielmeier, F.; Janssen, K.-P.; Ruland, J.; Kreutz, M.; Weber, D.; Schmidl, C.; Koehler, N.; Tschurtschenthaler, M.; Hoffmann, P.; Edinger, M.; Wolff, D.; Bassermann, F.; Rehli, M.; Haller, D.; Evert, M.; Hildner, K.; Buettner-Herold, M.; Herr, W.; Gessner, A.; Heidegger, S.; Holler, E.; Poeck, H.

10.1101/2025.04.08.647747 — immunology — Posted on 2025-04-15

2882 Impaired online and enhanced offline motor sequence learning in individuals with Parkinson's disease

Van Roy, A.; Dan, X.; Micca, L.; Gilat, M.; Chan, P.; Doyon, J.; Albouy, G.; King, B.

10.1101/2024.11.14.623568 — neuroscience — Posted on 2025-04-15

2883 Accurate and rapid determination of metabolic flux by deep learning of isotope patterns

Law, R. C.; Pande, K.; O'Keeffe, S.; Nurwono, G.; Ki, R.; Lai, P.-K.; Park, J. O.

10.1101/2023.11.06.565907 — systems biology — Posted on 2025-04-15

2884 Exploring use of a protein cage system for producing bioactive peptides in Escherichia coli

Harding, M. D.; Jackson, M. A.; Gilding, E. K.; Yap, K.; Craik, D. J.; Sainsbury, F.; Lawrence, N.

10.1101/2024.12.16.628579 — synthetic biology — Posted on 2025-04-15

2885 Scalable and cost-efficient custom gene library assembly from oligopools

Freschlin, C.; Yang, K.; Romero, P. A.

10.1101/2025.03.22.644747 — synthetic biology — Posted on 2025-04-15

2886 Direct high-throughput deconvolution of non-canonical bases via nanopore sequencing and bootstrapped learning

Perez, M.; Kimoto, M.; Rajakumar, P.; Suphavilai, C.; Peres da Silva, R.; Pen Tan, H.; Ting Xun Ong, N.; Nicholas, H.; Hirao, I.; Wei Leong, C.; Nagarajan, N.

10.1101/2024.12.02.625113 — synthetic biology — Posted on 2025-04-15

2887 Fenretinide targets GATA1 to induce cytotoxicity in GATA1 positive Acute Erythroid and Acute Megakaryoblastic Leukemic cells.

Raza, Y.; Elmasry, M.; Yu, G.; Chiappone, S. B.; Liu, S.; Luberto, C.

10.1101/2025.01.19.633759 — cancer biology — Posted on 2025-04-15

2888 Serotonin signaling in the rat prefrontal cortex is required for Retrieval-Induced Forgetting

Zanoni, M. B.; Imperatori, M.; Bentivegna, M.; Anderson, M.; Bekinschtein, P.; Weisstaub, N.

10.1101/2025.03.05.641624 — animal behavior and cognition — Posted on 2025-04-15

2889 Longitudinal dynamics of gut plasmidome and antibiotic resistance during antibiotic therapy: a case report

Jonsdottir, I.; Meaden, S.; Salminen, P.; Kallonen, T.; Ravantti, J.; Pajander, A.; Vanhatalo, S.; Jalasvuori, M.; Sundberg, L.-R.; Westra, E.; Van Houte, S.; Hakanen, A. J.; Penttinen, R.

10.1101/2025.04.12.648487 — microbiology — Posted on 2025-04-14

2890 Brain Diffusion Transformer for Personalized Neuroscience and Psychiatry

Zhai, R.; Hu, Y.; Zheng, L.; Xiang, S.; Xie, C.; Peng, L.; Banaschewski, T.; Barker, G. J.; Bokde, A. L. W.; Bruehl, R.; Desrivieres, S.; Flor, H.; Garavan, H.; Gowland, P.; Grigis, A.; Heinz, A.; Lemaitre, H.; Martinot, J.-L.; Martinot, M.-L. P.; Artiges, E.; Nees, F.; Orfanos, D. P.; Poustka, L.; Smolka, M. N.; Hohmann, S.; Holz, N.; Vaidya, N.; Whelan, R.; Zhang, Z.; Robinson, L.; Winterer, J.; King, S.; Zhang, Y.; Kebir, H.; Schmidt, U.; Sinclair, J.; Stringaris, A.; Schumann, G.; Bzdok, D.; Walter, H.; Rolls, E. T.; Sahakian, B.; Robbins, T. W.; Feng, J.; Gong, W.; Jia, T.; IMAGEN Consort

10.1101/2025.04.12.648506 — neuroscience — Posted on 2025-04-14

2891 TD2: finding protein coding regions in transcripts

Mao, A.; Ji, H. J.; Haas, B.; Salzberg, S.; Sommer, M. J.

10.1101/2025.04.13.648579 — genomics — Posted on 2025-04-14

2892 Inferring a novel insecticide resistance metric and exposurevariability in mosquito bioassays across Africa

Denz, A.; Kont, M. D.; Sanou, A.; Churcher, T. S.; Lambert, B.

10.1101/2024.03.09.584248 — bioinformatics — Posted on 2025-04-14

2893 Single-Molecule Kinetic Exploration of Functional Substates in an Evolving Phosphotriesterase

Sakuma, M.; Mahato, D. R.; Feixas, F.; Jackson, C. J.; Nakata, E.; Osuna, S.; Tokuriki, N.

10.1101/2025.04.14.648755 — biochemistry — Posted on 2025-04-14

2894 Old age variably impacts chimpanzee engagement and efficiency in stone tool use

Howard-Spink, E.; Matsuzawa, T.; Carvalho, S.; Hobaiter, C.; Almeida-Warren, K.; Gruber, T.; Biro, D.

10.1101/2024.11.25.625128 — animal behavior and cognition — Posted on 2025-04-14

2895 Seasonal transcriptional profiling of malaria parasites using a new single-cell atlas of a Malian Plasmodium falciparum isolate

Votborg-Novel, L.; Kampmann, M.; Carrasquilla, M.; Angeli, G.; Ntalla, C.; Cisse, H.; Sogoba, Y.; Guerra, G. M.; Doumbo, S. N.; Doumtabe, D.; Bandermann, S.; Cuesta-Valero, Y.; Kayentao, K.; Mashreghi, M.-F.; Niangaly, M.; Crompton, P. D.; Otto, T. D.; Traore, B.; Portugal, S.

10.1101/2025.04.14.648697 — molecular biology — Posted on 2025-04-14

2896 Nanocluster-antibody-drug conjugates (NADC) as an intravesical precision theranostic agent for interstitial cystitis

Lin, Z.; Wang, W.; Liu, D.; Liu, Q.; Wang, C.; Xu, Z.; Wu, Z.; Zhou, X.; Zhang, X.; Huang, Y.; Zhao, Q.; Yang, J.

10.1101/2024.04.20.590432 — microbiology — Posted on 2025-04-14

2897 Validation of diverse and previously untraceable Sendai virus copyback viral genomes by Direct RNA Sequencing

Pye, S.; Achouri, E.; Yang, Y.; Musa, A.; Lopez, C. B.

10.1101/2025.04.04.647164 — microbiology — Posted on 2025-04-14

2898 Emerging Resistance to Novel -βLactam β-Lactamase Inhibitor Combinations in Klebsiella pneumoniae bearing KPC Variants

Hamza, M.; Traglia, G. M. M.; Maccari, L.; Gomez, S.; Sanz, M. B.; Akhtar, U.; Mezcord, V.; Escalante, J.; Corso, A.; Rodriguez, C.; Bethel, C. R.; Rao, G. G.; Tolmasky, M. E.; Paterson, D.; Bonomo, R. A.; Pasteran, F.; Ramirez, M. S.

10.1101/2025.04.14.648765 — microbiology — Posted on 2025-04-14

2899 Phenotypic and omics analyses of the Sordariomycetes Marquandomyces marquandii and Albophoma yamanashiensis isolated from estuarine sediments.

Agirrezabala, Z.; Otamendi, A.; Liebana, R.; Azkargorta, M.; Perez-Cruz, C.; Duenas, M. T.; Ostra, M.; Lopez, R.; Grigoriev, I. V.; Alonso-Saez, L.; Elortza, F.; Lanzen, A.; Haridas, S.; Etxebeste, O.

10.1101/2023.07.26.550687 — microbiology — Posted on 2025-04-14

2900 Peak alpha frequency is not significantly altered by five days of experimental pain and repetitive transcranial stimulation of the left dorsolateral prefrontal cortex

Millard, S. K.; Chiang, A. K.; Chowdhury, N.; Chang, W.-J.; Furman, A. J.; De Martino, E.; Graven-Nielsen, T.; Schabrun, S. M.; Seminowicz, D. A.

10.1101/2024.06.14.599003 — neuroscience — Posted on 2025-04-14

2901 Ketamine Alters Tuning of Neural and Behavioral Spatial Working Memory Precision

Rahmati, M.; Moujaes, F.; Suljic, N. P.; Ji, J. L.; Berkovitch, L.; Lee, K.; Fonteneau, C.; Schleifer, C. H.; Adkinson, B. D.; Savic, A.; Santamauro, N.; Tamayo, Z.; Diehl, C.; Kolobaric, A.; Flynn, M.; Camarro, T.; Curtis, C. E.; Repovs, G.; Fineberg, S. K.; Morgan, P. T.; Preller, K. H.; Krystal, J. H.; Murray, J. D.; Cho, Y. T.; Anticevic, A.

10.1101/2025.02.10.637233 — neuroscience — Posted on 2025-04-14

2902 Inactivation of primate area V4 reveals inductive biases in visual learning.

Laamerad, P.; Krause, M. R.; Guitton, D.; Pack, C. C.

10.1101/2025.03.11.642616 — neuroscience — Posted on 2025-04-14

2903 The Simultaneous Measurement of Reversed Phase-Encoding EPI in a Single fMRI Session: Evaluation of Geometric Distortion Correction in Submillimetre fMRI at 7T

Yun, S. D.; Genc, E.; Lee, J.; Shah, J.

10.1101/2024.09.26.615120 — neuroscience — Posted on 2025-04-14

2904 Vowel-like patterns modulate auditory P100m response but not its association with language abilities in children with ASD

Fadeev, K. A.; Romero Reyes, I. V.; Goiaeva, D. E.; Obukhova, T. S.; Ovsiannikova, T. M.; Prokofyev, A. O.; Rytikova, A. M.; Novikov, A. Y.; Stroganova, T. A.; Orekhova, E. V.

10.1101/2025.04.10.648101 — neuroscience — Posted on 2025-04-14

2905 Synergistic roles of Aquaporin 5 and Intra- and Extracellular Carbonic Anhydrases In facilitating CO2 Diffusionacross the Xenopus Oocyte Plasma Membrane

Wang, D.; Moss, F. J.; Boron, W. F.

10.1101/2025.04.08.647833 — physiology — Posted on 2025-04-14

2906 The penetration ring is a novel infection structure formed by the penetration peg for invading plant cell membrane in rice blast fungus

Fang, W.; Zai, X.; Chen, J.; Abubakar, Y. S.; Wu, Q.; Fang, Z.; Huang, X.; Gan, X.; Ebbole, D. J.; Wang, Z.; Zheng, W.

10.1101/2024.07.11.603048 — pathology — Posted on 2025-04-14

2907 IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models

Singh, K.; Hotchkiss, K. M.; Cook, S. L.; Noldner, P.; Zhou, Y.; Moelker, E. M.; Railton, C. O.; Blandford, E. E.; Puviindran, B. J.; Wallace, S. E.; Norberg, P. K.; Archer, G. E.; Shaz, B. H.; Ayasoufi, K.; Sampson, J. H.; Khasraw, M.; Fecci, P. E.

10.1101/2024.04.01.587634 — cancer biology — Posted on 2025-04-14

2908 CXCL12 chemokine dimer signaling modulates acute myelogenous leukemia cell migration through altered receptor internalization

Drouillard, D.; Halyko, M.; Cinquegrani, E.; Poimenidou, M.; Emosivbe, M.; McAllister, D.; Peterson, F. C.; Marchese, A.; Dwinell, M. B.

10.1101/2024.08.26.609725 — cancer biology — Posted on 2025-04-14

2909 SLUR(M)-py: A SLURM Powered Pythonic Pipeline for Parallel Processing of 3D (Epi)genomic Profiles

Roth, C. J. N.; Venu, V.; Bacot, S.; Starkenburg, S. R.; Steadman, C. R.

10.1101/2024.05.18.594827 — bioinformatics — Posted on 2025-04-14

2910 Passive Acoustic Dynamic Differentiation and Mapping: A Time-Domain Passive Cavitation Localization and Classification Approach

Caso, N.; Patel, K. S.; Sun, T.

10.1101/2025.04.08.647829 — bioengineering — Posted on 2025-04-14

2911 Quantifying and modeling loss of steroid hormones in PDMS-based devices

Hermann, N. G.; Ficek, R. A.; Markov, D. A.; McCawley, L. J.; Hutson, M. S.

10.1101/2025.04.08.647867 — bioengineering — Posted on 2025-04-14

2912 Identification of the trail-following pheromone receptor in termites

Diallo, S.; Kasparova, K.; Sulc, J.; Johny, J.; Krivanek, J.; Nebesarova, J.; Sillam-Dusses, D.; Kyjakova, P.; Vondrasek, J.; Machara, A.; Luksan, O.; Grosse-Wilde, E.; Hanus, R.

10.1101/2024.07.24.605012 — animal behavior and cognition — Posted on 2025-04-14

2913 Investigating the molecular basis of cleptobiosis in eusocial stingless bees (Apidae: Hymenoptera)

Ricardo, P. C.; Araujo, N. d. S.; Arias, M. C.

10.1101/2024.01.12.575469 — genomics — Posted on 2025-04-14

2914 A systemically delivered AAV-CFTR gene therapy for cystic fibrosis

Plasschaert, L. W.; Stutz, C.; Otarola, E.; Ruggeri, L.; Misiolek, R. V.; Nuccio, A.; Shang, J.; Choo-Wing, R.; Taddase, B.; Decock, A.; Quigley, C.; Kubek-Luck, K.; Warnant, I.; Aibo, D. I.; Magnifico, M.; Buchs, M.; Tan, G.; Ashley, L.; Wang, H.-K.; Watson, R.; Lin, A.

10.1101/2025.03.20.642115 — genetics — Posted on 2025-04-14

2915 Cell-cycle regulator Whi5 shapes proliferative heterogeneity in clonal populations from the first divisions of newborn cells

Delgado-Roman, I.; Garcia Marcelo, M. J.; Delgado-Ramos, L.; Chavez, S.; Munoz-Centeno, M. C.

10.1101/2023.04.20.537656 — molecular biology — Posted on 2025-04-14

2916 The Mycobacterium tuberculosis long-chain fatty acid resistome reveals the universal stress protein TB15.3 as essential for infection

Pinto, A. J.; Silva, M.; Santos, J. A.; VanderVen, B. C.; Schnappinger, D.; Ehrt, S.; Beites, T.

10.1101/2025.04.14.648703 — microbiology — Posted on 2025-04-14

2917 Sensitivity of Bud Rot (Phytophthora sp.) Isolated from Coconut Palms in Jamaica to local Commercial Fungicide Pilarzox and Turmeric powder.

Myrie, W.; Hanchard, C.

10.1101/2025.04.13.648621 — microbiology — Posted on 2025-04-14

2918 A neural network model that generates salt concentration memory-dependent chemotaxis in Caenorhabditis elegans

Hironaka, M.; Sumi, T.

10.1101/2024.11.04.621960 — neuroscience — Posted on 2025-04-14

2919 Virtual electrode or virtual scalpel?

de Cheveigne, A.

10.1101/2023.09.19.558390 — neuroscience — Posted on 2025-04-14

2920 Experience reorganizes content-specific memory traces in macaques

Abbaspoor, S.; Aljishi, A.; Hoffman, K. L.

10.1101/2025.04.08.647787 — neuroscience — Posted on 2025-04-14

2921 How learning to read visual Braille co-opts the reading brain

Cerpelloni, F.; Van Audenhaege, A.; Matuszewski, J.; Gau, R.; Battal, C.; Falagiarda, F.; Op de Beeck, H.; Collignon, O.

10.1101/2024.05.08.593104 — neuroscience — Posted on 2025-04-14

2922 Application of Whole Proteome Thermal Shift Assays to Define PERK-dependent Changes in Protein Homeostasis during the Unfolded Protein Response

McCracken, N. A.; Justice, S. A. P.; Smith-Kinnaman, W. R.; Wijeratne, H. S.; Runnebohm, A. M.; Pelletier, S.; Doud, E. H.; Wek, R. C.; Mosley, A. L.

10.1101/2025.04.08.647882 — systems biology — Posted on 2025-04-14

2923 Structural variations contribute to subspeciation and heterosis in rice

Dan, Z.; Chen, Y.; Huang, W.

10.1101/2024.11.03.621459 — plant biology — Posted on 2025-04-14

2924 An experimental approach to study multi-species interactions implicated in Fusarium-Head Blight complex assembly in wheat.

Corrales Gutierrez, M. A.; Kaur, H.; Desiderio, F.; Douchkov, D.; Zhan, J.; Velez, H.; Bourras, S.

10.1101/2024.04.14.589412 — plant biology — Posted on 2025-04-14

2925 General Theory of Metabolism related to Animal's Taxonomy and Size

Pelz, P. F.

10.1101/2025.04.08.647784 — physiology — Posted on 2025-04-14

2926 Effects of childhood hearing loss on the subcortical and cortical representation of speech

Calcus, A.; Rosen, S.

10.1101/2024.02.22.581639 — physiology — Posted on 2025-04-14

2927 Inhibition of p38-MK2 pathway enhances the efficacy of microtubule inhibitors in breast cancer cells

Chen, Y.-C.; Takada, M.; Nagornyuk, A.; Yu, M.; Yamada, H.; Nagashima, T.; Ohtsuka, M.; DeLuca, J. G.; Markus, S. M.; Takaku, M.; Suzuki, A.

10.1101/2024.11.04.621816 — cancer biology — Posted on 2025-04-14

2928 Non-equilibrium remodelling of collagen-IV networks in silico

Meadowcroft, B.; Sorichetti, V.; Ratajczyk, E.; Khalilgharibi, N.; Mao, Y.; Palaia, I.; Saric, A.

10.1101/2024.10.10.617412 — biophysics — Posted on 2025-04-14

2929 Data-efficient protein mutational effect prediction with weak supervision by molecular simulation and protein language models

Deguchi, T.; Kurumida, Y.; Iida, S.; Kobayashi, K.; Saito, Y.

10.1101/2025.04.08.647800 — bioinformatics — Posted on 2025-04-14

2930 PepBERT: Lightweight language models for peptide representation

Du, Z.; Li, Y.

10.1101/2025.04.08.647838 — bioinformatics — Posted on 2025-04-14

2931 Genetic variants linked to neurodevelopmental disorders within the β3-β4 loop of the TRIO PH2 domain release autoinhibition of GEF2 activity.

Carrizales, M. G.; Boulton, A.; Koleske, A. J.

10.1101/2025.04.14.648796 — biochemistry — Posted on 2025-04-14

2932 Catalytic Mechanism and Differential Alarmone Regulation of a Conserved Stringent Nucleosidase

Barentsen, R.; Kronborg, K.; Brodersen, D. E.; ZHANG, Y. E.

10.1101/2025.04.13.648610 — biochemistry — Posted on 2025-04-14

2933 A structural basis for chaperone repression of stress signalling from the endoplasmic reticulum

Neidhardt, L.; Tung, J.; Kuchersky, M.; Milczarek, J.; Kargas, V.; Stott, K.; Rosenzweig, R. S.; Ron, D.; Yan, Y.

10.1101/2025.04.14.648677 — biochemistry — Posted on 2025-04-14

2934 Designed NGF mimetics with reduced nociceptive signatures in neurons

Schlichthaerle, T.; Yang, A.; Detraux, D.; Johnson, D. E.; Peach, C. J.; Edman, N. I.; Sniezek, C.; Williams, C. A.; Arora, S.; Katiyar, N.; Chen, I.; Etemadi, A.; Favor, A.; Lee, D.; Kubo, C.; Coventry, B.; Huang, B.; Gerben, S.; Ennist, N. M.; Milles, L.; Sankaran, B.; Kang, A.; Nguyen, H.; Bera, A. K.; Negahdari, B.; Hamazaki, N.; Schweppe, D. K.; Stewart, L.; Young, J. E.; Bunnett, N. W.; Ruohola-Baker, H.; Mathieu, J.; Pattwell, S.; Garcia, K. C.; Baker, D.

10.1101/2025.04.14.648806 — biochemistry — Posted on 2025-04-14

2935 Preliminary characterization of CbcS from Geobacter sulfurreducens ' Cbc4 complex: a putative novel respiratory pathway

Fernandes, M. V.; Antunes, J. M. A.; Salgueiro, C. A.; Morgado, L.

10.1101/2025.04.14.648717 — biochemistry — Posted on 2025-04-14

2936 The reliability of environmental cues shape learning and selection against deleterious alleles in seed beetles

Caddy, L.; Munoz, T.; Baur, J.; von Schmalensee, L.; Berger, D.

10.1101/2025.03.23.644788 — animal behavior and cognition — Posted on 2025-04-14

2937 A Model of Ethanol Self-Administration in Head-Fixed Mice

Ward, A. L.; Winston, K. T.; Buchmaier, S. A.; Cooper, C. J.; Clarke, R. E.; Martino, M. R.; Vollmer, K. M.; Paniccia, J.; Bell, M. S.; Doncheck, E. M.; Grant, R. I.; Boquiren, J.; Baek, J.; Manusky, L. M.; Westphal, A. M.; Green, L. M.; Pagoota, B. E.; Otis, J. M.; Rinker, J. A.

10.1101/2024.02.17.580838 — animal behavior and cognition — Posted on 2025-04-14

2938 Sex differentiation, divergence, and introgression in the leishmaniasis vector Lutzomyia longipalpis

Stuckert, A. M.; Turissini, D.; DAgostino, E. R.; Peede, D.; Parvathaneni, M.; Rader, J. A.; Muskus, C.; Bejarano, E.; Wang, J. R.; Vivero, R.; Matute, D. R.

10.1101/2025.04.08.647763 — genomics — Posted on 2025-04-14

2939 Precision and Accuracy in Quantitative Measurement of Gene Expression from Single-Cell/Nuclei RNA Sequencing Data

Dai, R.; Zhang, M.; Chu, T.; Kopp, R.; Zhang, C.; Liu, K.; Wang, Y.; Wang, X.; Chen, C.; Liu, C.

10.1101/2024.04.12.589216 — genomics — Posted on 2025-04-14

2940 Research on Crop Phenotype Prediction Methods Based on SNP-context and Whole-genome Features Embedding

Huan, L.; peng, C. Y.; Zhen, C.; Ting, W.; Chao, W.; bo, B. W.; Juan, L.; Mo, W.; Li, C.; ming, W. J.

10.1101/2025.04.08.647762 — genetics — Posted on 2025-04-14

2941 Species biology and demographic history determine species vulnerability to climate change in tropical island endemic birds

Karjee, R.; Iyer, V.; Chatterjee, D.; Ray, R.; Garg, K. M.; Chattopadhyay, B.

10.1101/2024.11.14.623644 — evolutionary biology — Posted on 2025-04-14

2942 An Essential Adaptor for Apicoplast Fission and Inheritance in Malaria Parasites

Blauwkamp, J. A.; Rajaram, K.; Staggers, S. R.; Harrigan, O.; Doud, E. H.; Prigge, S. T.; Sun, S. Y.; Absalon, S.

10.1101/2025.04.12.648511 — cell biology — Posted on 2025-04-14

2943 The Adhesion GPCR ADGRL2 engages Gα13 to Enable Epidermal Differentiation

Yang, X.; He, F.; Porter, D. F.; Garbett, K.; Meyers, R. M.; Reynolds, D. L.; Duy, L. H. B.; Hong, A.; Ducoli, L.; Siprashvili, Z.; Lopez-Pajares, V.; Mondal, S.; Ko, L.; Jing, Y.; Tao, S.; Singal, B.; Sando, R.; Skiniotis, G.; Khavari, P. A.

10.1101/2025.02.19.639154 — cell biology — Posted on 2025-04-14

2944 LncRNA Dio3os regulates neighboring gene Dio3 and impacts osteogenesis in trans

Hassan, Q.; Chen, Y.; Wldman, B. J.; Rehn, M.; Mishra, S.

10.1101/2025.04.14.647401 — molecular biology — Posted on 2025-04-14

2945 ATRX promotes transcription initiation of HSV-1 immediate early genes during early lytic infection

Dunn, L. E. M.; Clark, M. M.; Baines, J. D.

10.1101/2025.04.14.648792 — molecular biology — Posted on 2025-04-14

2946 Activation of the Pseudomonas aeruginosa Glycerol Regulon Promotes Antibiotic Persistence and Modulates Virulence Phenotypes

Evans, N. J.; Scoffield, J. A.

10.1101/2025.04.14.648800 — microbiology — Posted on 2025-04-14

2947 Evolutionary Constraints on RNA Polymerase Gene Positioning in the Genome of Fast-Growing Bacteria..

Larotonda, L. I.; Ojeda, E.; Bordignon, M. B.; Fulgenzi, F. R.; Comerci, D. J.; Val, M.-E.; Llorente, B. E.; Mazel, D.; Soler-Bistue, A.

10.1101/2025.04.14.645983 — microbiology — Posted on 2025-04-14

2948 Identifying a novel mechanism of L-leucine uptake in Mycobacterium tuberculosis using a chemical genomic approach

Agarwal, N.; Gogoi, H.; Eeba, E.; Augustin, L.; Khan, M. Y.; Kumar, Y.; Bhowmick, S. K.; Dey, B.

10.1101/2025.04.14.648691 — microbiology — Posted on 2025-04-14

2949 Vector Competence of Temperate and Tropical Mosquito Species for Babanki virus

Ban, M.; Geolier, V.; Ferquel, E.; Faye, M.; Diagne, M. M.; Ndiaye, E. H.; Fall, G.; Diallo, M.; Lavillette, D.; Choumet, V.

10.1101/2025.04.14.648682 — microbiology — Posted on 2025-04-14

2950 Calprotectin protects Staphylococcus aureus in coculture with Pseudomonas aeruginosa by attenuating quorum sensing and decreasing the production of pseudomonal antimicrobials

Lee, W. H.; Oglesby, A. G.; Nolan, E. M.

10.1101/2025.04.14.648724 — microbiology — Posted on 2025-04-14

2951 Single-cell resolution genetic association analysis of heterogeneous bacterial communities by utilizing droplet digital PCR

Dutra, L. A. L.; Jalasvuori, M.; Franz, O.; Nurminen, K.; Salmi, P.; Tiirola, M.; Penttinen, R.

10.1101/2022.09.27.509627 — microbiology — Posted on 2025-04-14

2952 Echoes of 1816: Microbial Footprints in Heritage Artifacts From Argentina's Museum of Independence

Alonso-Reyes, D. G.; Galvan, F. S.; Alvarado, N.; D'Arpino, C.; Martinez, L. J.; Esquivel, H. J.; Gallardo, C. A.; Silva Manco, M. J.; Albarracin, V. H.

10.1101/2025.03.28.645971 — microbiology — Posted on 2025-04-14

2953 Comparative susceptibility of Old World and New World bat cell lines to Zika virus: Insights into viral replication and inflammatory responses

Brown, A. J.; Fagre, A. C.; Gilson, J.; Horton, J.; Rivero, R.; Karimi, M.; Speranza, E.; Letko, M. C.; Seifert, S. N.

10.1101/2025.03.27.645813 — microbiology — Posted on 2025-04-14

2954 De novo design and structure of a peptide-centric TCR mimic binding module

Householder, K. D.; Xiang, X.; Jude, K. M.; Deng, A.; Obenaus, M.; Wilson, S. C.; Chen, X.; Wang, N.; Garcia, K. C.

10.1101/2024.12.16.628822 — immunology — Posted on 2025-04-14

2955 Machine learning-based prediction of dynamic height heterosis with pathway biomarkers in rice

Dan, Z.; Chen, Y.; Huang, W.

10.1101/2024.11.09.622823 — systems biology — Posted on 2025-04-14

2956 Efficient genetic code expansion tools enable in vivo study of lysine acetylation in non-model bacteria

Van Fossen, E. M.; Stephenson, M.; Frank, A.; Akella, S.; Wooldridge, R.; Wilson, A.; You, Y.; Nakayasu, E.; Egbert, R.; Elmore, J. R.

10.1101/2025.04.14.648644 — synthetic biology — Posted on 2025-04-14

2957 High radiosensitivity in the conifer Norway spruce (Picea abies) due to lesscomprehensive mobilisation of protection and repair responses compared to the radiotolerant Arabidopsis thaliana

Bhattacharjee, P.; Blagojevic, D.; Lee, Y.; Gillard, G. B.; Gronvold, L.; Hvidsten, T. R.; Sandve, S. R.; Lind, O. C.; Salbu, B.; Brede, D. A.; Olsen, J. E.

10.1101/2023.11.20.562501 — plant biology — Posted on 2025-04-14

2958 Customizable host and viral transcript enrichment using CRISPR-Cas9 long-read sequencing for isoform discovery and validation

Nguyen, A. N. T.; Zhang, J.; Zhang, S.; Pitt, M. E.; Ganesamoorthy, D.; Fritzlar, S.; Chang, J. J. Y.; Londrigan, S.; Coin, L. J. M.

10.1101/2025.04.11.648353 — genomics — Posted on 2025-04-14

2959 Arsenic Toxicity in the Drosophila Brain at Single Cell Resolution

Chaturvedi, A.; Shankar, V.; Simkhada, B.; Lyman, R. A.; Freymuth, P.; Howansky, E.; Collins, K. M.; Mackay, T. F. C.; Anholt, R. R. H. R. H.

10.1101/2025.04.09.647950 — genetics — Posted on 2025-04-14

2960 Repressive S-adenosylmethionine biosynthesis status inhibits transcription of HeT-A retrotransposon in the germline of Drosophila.

Hayashi, Y.; Hino, S.; Sato, T.; Kashio, S.; Saito, K.; Sato, B.; Kawano, N.; Saito, D.; Miura, M.; Suyama, M.; Nakao, M.; Kobayashi, S.

10.1101/2025.04.12.648310 — developmental biology — Posted on 2025-04-14

2961 CO2 sensitive connexin channel synapses in the VTA release 5HT to regulate dopaminergic neurons

Huang, L.; Butler, J.; Lovatt, A.; Bhandare, A.; Pelletier, J.; Hill, E.; Dale, N.; wall, M. J.

10.1101/2025.04.14.648741 — neuroscience — Posted on 2025-04-14

2962 Modeling AP2M1 Developmental and Epileptic Encephalopathy in Drosophila

Karge, R. A.; Fischer, F. P.; Schüth, H.; Wechner, A.; Peter, S.; Kilo, L. A.; Dichter, M.; Voigt, A.; Tavosanis, G.; van Loo, K. M. J.; Koch, H.; Weber, Y.; Wolking, S.

10.1101/2025.04.11.648441 — neuroscience — Posted on 2025-04-14

2963 Glia phagocytose neuronal sphingolipids to infiltrate developing synapses

Theisen, E. K.; Rivas-Serna, I. M.; Lee, R. J.; Jay, T. R.; Kunduri, G.; Nguyen, T. T.; Freeman, M. R.; Mazurak, V.; Clandinin, M. T.; Clandinin, T. R.; Vaughen, J. P.

10.1101/2025.04.14.648777 — neuroscience — Posted on 2025-04-14

2964 Unfolding admixed ancestry and genomic diversity in zoo giraffes

Fraser, M. F.; Heller, R.; Bertola, L. D.; Hvilsom, C.; Balboa, R. F.; Liu, X.; Bruniche-Olsen, A.

10.1101/2025.03.31.645993 — evolutionary biology — Posted on 2025-04-14

2965 Nucleus softens during herpesvirus infection

Tervonen, A.; Leclerc, S.; Ruokolainen, V.; Tieu, K.; Lyonnais, S.; Niskanen, H.; Chen, J.-H.; Gupta, A.; Kaikkonen, M. U.; Larabell, C. A.; Muriaux, D.; Mattola, S.; Conway, D. E.; Ihalainen, T. O.; Aho, V.; Vihinen-Ranta, M.

10.1101/2025.01.03.631188 — cell biology — Posted on 2025-04-14

2966 Enantiomeric Hydrogel-Manipulated Mechanotransduction Triggers Neurogenesis and Immunomodulation for Spinal Cord Repair

Li, Y.; Wang, Y.; Fang, X.; Zhang, H.; Li, R.; Cai, R.; Li, X.; Yang, Z.; Li, X.; Huang, Z.; Yin, G.; Wang, A.; Ao, Q.

10.1101/2025.01.10.632462 — neuroscience — Posted on 2025-04-14

2967 Stromal and Endothelial Transcriptional Changes during progression from MGUS to Myeloma and after Treatment Response

Cenzano, I.; Cocera, M.; Larrayoz, M.; Campos-Dopazo, L.; Sanz, S.; Bantan, A.; Vilas, A.; San-Martin, P.; Aguirre-Ruiz, P.; Alignani, D.; Lopez, A.; Sancho Gonzalez, I.; Ruiz, J.; Ripalda-Cemborain, P.; Abengozar-Muela, M.; Muinos-Lopez, E.; Lagani, V.; Tegner, J.; Hernaez, M.; Agirre, X.; Ebert, B.; Paiva, B.; Rodriguez-Otero, P.; Tamariz-Amador, L.-E.; San-Miguel, J.; Saez, B.; Martinez-Climent, J. A.; Calvo, I. A.; Gomez-Cabrero, D.; Prosper, F.

10.1101/2024.04.24.589777 — cancer biology — Posted on 2025-04-14

2968 State-specific Peptide Design Targeting G Protein-coupled Receptors

Xue, Y.; Wang, H.; Li, J.; Hu, J.; Chen, Z.; Zheng, Z.; Liu, L.; Zhu, K.; He, J.; Gong, H.; Li, X.; Zhang, X.; Fang, X.

10.1101/2024.11.27.625792 — bioinformatics — Posted on 2025-04-14

2969 Deep generalizable prediction of RNA secondary structure via base pair motif energy

Zhu, H.; Tang, F.; Quan, Q.; Chen, K.; Xiong, P.; Zhou, S. K.

10.1101/2024.10.22.619430 — bioinformatics — Posted on 2025-04-14

2970 A fractal pattern of hierarchical genetic population structure in mixed stocks across fish segregated by dams revealed by genomic resources for curimba Prochilodus lineatus

Yazbeck, G. M.; Nascimento, G. A. S.; Carvalho, L. C.; Graciano, R. C. D.; Santos, R.; Oliveira, R. S.

10.1101/2025.03.14.643328 — genetics — Posted on 2025-04-14

2971 The Hitchdock Domain in Kinesin-2 Tail Enables Adaptor Assembly and Cargo Binding

Jiang, X.; Danev, R.; Niu, B.; Ohtsuki, S.; Yanagisawa, H.; Hirokawa, N.; Kikkawa, M.

10.1101/2025.03.21.644525 — cell biology — Posted on 2025-04-14

2972 Degradation of resistant α-1,4-glucan by vaginal Gardnerella species is associated with bacterial vaginosis

Hertzberger, R.; Morselli, S.; Botschuijver, S.; Himschoot, L.; Bruisten, S.; Steenbergen, L.; Lewis, W.; Cools, P.; Kort, R.

10.1101/2023.01.28.526025 — microbiology — Posted on 2025-04-14

2973 Planetary-scale heterotrophic microbial community modeling assesses metabolic synergy and viral impacts

Regimbeau, A.; Tian, F.; Smith, G.; Riddell, J.; Andreani, C.; Bordron, P.; Budinich, M.; Howard-Varona, C.; Larhlimi, A.; Ser-Giacomi, E.; Trottier, C.; Guidi, L.; Hallam, S. J.; Iudicone, D.; Karsenti, E.; Maass, A.; Sullivan, M. B.; Eveillard, D.

10.1101/2025.02.13.638167 — systems biology — Posted on 2025-04-14

2974 The auxin gatekeepers: Evolution and diversification of the YUCCA family

Vijayanathan, M.; Faryad, A.; Abeywickrama, T. D.; Christensen, J. M.; Neilson, E. H.

10.1101/2025.04.11.648386 — plant biology — Posted on 2025-04-14

2975 Identification of MARVELlous Protein Markers for Phytophthora infestans Extracellular Vesicles

Breen, S.; McLellan, H.; Wang, W.; Wang, S.; Welsh, L.; Pham, J.; Whisson (SW), s.; Boevink, P.; Birch, P. R.

10.1101/2025.04.11.648357 — plant biology — Posted on 2025-04-14

2976 Arsenic-sensing domain controls ACR3 transporter trafficking and function in Marchantia polymorpha

Mizio, K.; Bonter, I.; Zbieralski, K.; Dolzblasz, A.; Tomaszewska, P.; Staszewski, J.; Wawrzycka, D.; Reymer, A.; Bialek, W.; Kriechbaumer, V.; Haseloff, J.; Wysocki, R.; Maciaszczyk-Dziubinska, E.

10.1101/2025.04.13.648538 — plant biology — Posted on 2025-04-14

2977 Comparative transcriptomics uncovers plant and fungal genetic determinants of mycorrhizal compatibility

Marques-Galvez, J. E.; de Freitas Pereira, M.; Nehls, U.; Ruytinx, J.; Barry, K.; Peter, M.; Martin, F.; Grigoriev, I. V.; Veneault-Fourrey, C.; Kohler, A.

10.1101/2025.04.11.648352 — plant biology — Posted on 2025-04-14

2978 RNA sequence analysis of somatic mutations in aging and Parkinson's Disease

Sun, S.; Sproviero, D.; Payan-Gomez, C.; Hoeijmakers, J.; Maslov, A. Y.; Mastroberardino, P. G.; Vijg, J.

10.1101/2025.03.26.645360 — genetics — Posted on 2025-04-14

2979 Revealing the range of maximum likelihood estimates in the admixture model.

Heinzel, C. S.; Baumdicker, F.; Pfafffelhuber, P.

10.1101/2024.10.18.619150 — genetics — Posted on 2025-04-14

2980 Corticotropin-releasing factor neurons of the bed nucleus of the stria terminalis demonstrate sex- and estrous phase-dependent differences in synaptic activity and in their role in anxiety-potentiated startle

Chudoba, R.; Dabrowska, J.

10.1101/2024.11.15.623898 — neuroscience — Posted on 2025-04-14

2981 Contribute to balance, wire in accordance: Emergence of backpropagation from a simple, bio-plausible neuroplasticity rule

Fan, X.; Mysore, S. P.

10.1101/2024.05.22.595438 — neuroscience — Posted on 2025-04-14

2982 A stochastic ratchet during genome streamlining can commit insect endosymbionts to a parasitic or mutualistic fate

Grigaitis, P.; Teusink, B.; LeBoeuf, A. C.

10.1101/2025.04.10.648247 — systems biology — Posted on 2025-04-14

2983 Arabidopsis HYPERSENSITIVE INDUCED REACTION 2 affects plasma membrane receptor pathways and organization

Weber, H.; Ehinger, A.; Kolb, D.; Fallahzadeh-Mamaghani, V.; Halter, T.; Franz-Wachtel, M.; zur Oven-Krockhaus, S.; Gronnier, J.; Zipfel, C.; Harter, K.; Kemmerling, B.

10.1101/2025.04.11.648320 — plant biology — Posted on 2025-04-14

2984 Recognition-dependent activation of the RRS1-R/RPS4 immune receptor complex

Ahn, H.-K.; Guo, G.; Sklenar, J.; Keh, S. P. Y.; Huh, S. U.; Hulin, M. T.; Burdett, H.; Sindalovskaya, M.; Choi, J.; Mukhi, N.; Zhao, H.; Knorr, L.; Banfield, M. J.; Menke, F.; Ma, W.; Jones, J. D.

10.1101/2025.04.11.646618 — plant biology — Posted on 2025-04-14

2985 Phantom controllers: Misspecified models create the false appearance of adaptive control during value-based choice

Ritz, H.; Frömer, R.; Shenhav, A.

10.1101/2023.01.18.524640 — animal behavior and cognition — Posted on 2025-04-14

2986 PsiConnect: A Multimodal Neuroimaging Study of Psilocybin-Induced Changes in Brain and Behaviour

Novelli, L.; Stoliker, D.; Barta, T.; Greaves, M. D.; Chopra, S.; Jackson, J.; Kwee, J.; Williams, M.; Razi, A.

10.1101/2025.04.11.643415 — neuroscience — Posted on 2025-04-14

2987 Dopaminergic drugs modulate fear extinction related processes in humans, but effects are mild

Doubliez, A.; Koster, K.; Muntefering, L.; Nio, E.; Diekmann, N.; Thieme, A.; Albayrak, B.; Nicksirat, S. A.; Erdlenbruch, F.; Batsikadze, G.; Ernst, T. M.; Cheng, S.; Merz, C. J.; Timmann, D.

10.1101/2025.04.11.648372 — neuroscience — Posted on 2025-04-14

2988 Fronto-parietal effective connectivity during working memory in Neurofibromatosis Type 1 adolescents and neurotypical controls

Litwinczuk, M. C.; Garg, S. C.; Green, J.; Lea-Carnall, C. A.; Trujillo-Barreto, N.

10.1101/2025.04.10.648183 — neuroscience — Posted on 2025-04-14

2989 Functional connectivity reveals increased network segregation and sensorimotor processing during working memory in adolescents with Neurofibromatosis Type 1

Litwinczuk, M. C.; Trujillo-Barreto, N.; Jung, J.; Garg, S.; Lea-Carnall, C. A.

10.1101/2025.04.10.648210 — neuroscience — Posted on 2025-04-14

2990 Microbes regulate glomerular filtration rate in health and chronic kidney disease in mice

Xu, J.; Verma, E.; Sanchez, J.; Gharaie, S.; Jeong, S.; Gooya, M.; Gupta, K.; Rabb, H.; Pluznick, J. L.

10.1101/2025.04.08.647647 — physiology — Posted on 2025-04-14

2991 Genetic control of the transcriptional response to active tuberculosis disease and treatment

O'Grady, J. F.; Leonard, A. S.; Li, H.; Fang, L.; Pausch, H.; Gormley, I. C.; Gordon, S. V.; MacHugh, D. E.

10.1101/2025.04.11.648383 — genetics — Posted on 2025-04-14

2992 ANKRD5: a key component of the axoneme required for spermmotility and male fertility

Yu, S.; Yin, G.; Jin, P.; Zhang, W.; Tian, Y.; Xu, X.; Shao, T.; Li, Y.; Sun, F.; Zhu, Y.; Wang, F.

10.1101/2024.12.03.626701 — developmental biology — Posted on 2025-04-14

2993 Incorporating Multi-threshold Polygenic Risk in Hippocampal-based Normative Models Improves Cognitive Decline Prediction

Janahi, M.; Lorenzini, L.; Oxtoby, N.; Barkhof, F.; Mokrab, Y.; Schott, J.; Altmann, A.

10.1101/2025.04.03.646991 — bioinformatics — Posted on 2025-04-14

2994 Life history evolution of insects in response to climate variation: seasonal timing versus thermal physiology

Gotthard, K.; Berger, D.; Rohner, P. T.

10.1101/2025.02.05.636251 — ecology — Posted on 2025-04-14

2995 Normalized Dynamic Time Warping Increases Sensitivity In Differentiating Functional Network Connectivity In Schizophrenia

Wiafe, S.-L.; Kinsey, S.; Iraji, A.; Miller, R.; Calhoun, V.

10.1101/2024.10.31.621415 — neuroscience — Posted on 2025-04-14

2996 Easydecon: A Lightweight Workflow for Cell Type Analysis in High-Definition Spatial Transcriptomics Assays

Umu, S. U.; Karlsen, V. T.; Baekkevold, E. S.; Jahnsen, F. L.; Domanska, D.

10.1101/2025.04.08.647764 — bioinformatics — Posted on 2025-04-14

2997 CODAvision: best practices and a user-friendly interface for rapid, customizable segmentation of medical images

Matos-Romero, V.; Gomez-Becerril, J.; Forjaz, A.; Dequiedt, L.; Newton, T.; Joshi, S.; Shen, Y.; Hanna, E.; Nair, P. R.; Sivasubramanian, A.; Wang, J.; Lasse-Opsahl, E. L.; Bell, A. T. F.; Czum, J.; Steenbergen, C.; Dai, D.-F.; Wood, L. D.; Kagohara, L. T.; Fertig, E. J.; Pasca di Magliano, M.; Shatzel, J.; McCarty, O. J.; Lo, J. O.; Rosenberg, A.; Hruban, R. H.; Munoz-Barrutia, A.; Wirtz, D.; Kiemen, A. L.

10.1101/2025.04.11.648464 — bioinformatics — Posted on 2025-04-14

2998 Cytonuclear analysis of barley spike traits using a cytoplasm-aware population

Fridman, E.; Bodenheimer, S.; Bdolach, E.; Be'ery, A.; Tiwari, L. D.; Prez-Alfaro, R. S.; Yang, S.; Koenig, D.

10.1101/2025.04.08.647843 — genetics — Posted on 2025-04-14

2999 FGF-dependent, polarized SOS activity orchestrates directed migration of C. elegans muscle progenitors independently of canonical effectors in vivo

Gibney, T. V.; Mardick, J. I.; Rasmussen, N. R.; Latifi, L.; Sundaram, M. V.; Reiner, D. J.; Pani, A. M.

10.1101/2025.04.11.648432 — cell biology — Posted on 2025-04-14

3000 Temporal shifts in microRNAs signify the inflammatory state of primary murine microglial cells

Zohar, K.; Lezmi, E.; Reichert, F.; Eliyahu, T.; Weinstock, M.; Linial, M.

10.1101/2025.04.11.648484 — cell biology — Posted on 2025-04-14

3001 Telomere Orchestrates Encapsulation of Mitotic Chromosomes

Yang, P. B.; Mikawa, T.

10.1101/2025.04.13.648587 — cell biology — Posted on 2025-04-14

3002 Human induced pluripotent stem cell-derived astrocyte and neuron co-culture model for neuroinflammation modeling

Qiu, B.; Caiazzo, M.

10.1101/2025.04.13.648609 — cell biology — Posted on 2025-04-14

3003 An Essential Adaptor for Apicoplast Fission and Inheritance in Malaria Parasites

Blauwkamp, J. A.; Rajaram, K.; Staggers, S. R.; Harrigan, O.; Doud, E. H.; Prigge, S. T.; Sun, S. Y.; Absalon, S.

10.1101/2025.04.12.648511 — cell biology — Posted on 2025-04-14

3004 BRAPH 2: a flexible, open-source, reproducible, community-oriented, easy-to-use framework for network analyses in neurosciences

Chang, Y.-W.; Zufiria-Gerboles, B.; Gomez-Ruiz, P. E.; Canal-Garcia, A.; Zhao, H.; Mijalkov, M.; Braga Pereira, J.; Volpe, G.

10.1101/2025.04.11.648455 — neuroscience — Posted on 2025-04-14

3005 Neuronal networks in the dorsal hippocampus causally regulate rescue behavior in mice

dos Santos Correa, M.; Agafonova, A.; Braun, A.; Omprakash, C.; Tafani, E.; Lowitsch, M.; Marquardt, L.; Bauer, P.; Albrecht, A.; Mikulovic, S.

10.1101/2025.04.08.647754 — neuroscience — Posted on 2025-04-14

3006 Neuroanatomy of catecholaminergic circuits in the brainstem and hypothalamus using T1-weighted and diffusion magnetic resonance imaging in humans: implications for brain-immune interactions, cardiovascular disease, neuropsychiatric disorders, stress response, and COVID-19

Hartung Toppa, P.; Rushmore, R. J.; Haggerty, K.; Papadimitriou, G.; Yeterian, E.; Castaneyra-Perdomo, A. L.; Makris, N.

10.1101/2025.04.11.644973 — neuroscience — Posted on 2025-04-14

3007 Pulsatory response of the BcLOV4 photoreceptor through intramolecular feed-forward regulation

Huang, Z.; Forson, M.; Benman, W.; Gardner, K. H.; Bugaj, L. J.

10.1101/2025.04.08.647774 — systems biology — Posted on 2025-04-14

3008 The Promotive Effect of Ocean Literacy on Marine Conservation Behavior: A Qualitative Study Based on Chinese University Students

wang, l.; Gao, B.; Chang, X.; Zhang, L.

10.1101/2025.04.11.648364 — scientific communication and education — Posted on 2025-04-14

3009 Untargeted metabolomics reveals key metabolites and genes underlying salinity tolerance mechanisms in maize

Brar, M. S.; De Souza, A.; Ghai, A.; Ferreira, J. F. S.; Sandhu, D.; Sekhon, R.

10.1101/2025.04.08.647850 — plant biology — Posted on 2025-04-14

3010 QTL identification and characterization of the recombination landscape of the mountain pine beetle (Dendroctonus ponderosae)

Pushman, C.; Ragland, G.; Pfrender, M.; Bentz, B.; Bracewell, R.

10.1101/2025.04.08.647844 — genetics — Posted on 2025-04-14

3011 Sexual signal reliability in male zebra finches: Food intake explains the impact of immune activation on carotenoid-based coloration

Cantarero, A.; Mateo, R.; Camarero, P.; Andrade, P.; Carneiro, M.; Alonso-Alvarez, C.

10.1101/2025.04.08.647553 — evolutionary biology — Posted on 2025-04-14

3012 A General Method for Detection and Segmentation of Terrestrial Arthropods in Images

Svenning, A.; Mougeot, G.; Alison, J.; Chevalier, D.; Molina, N. L. C.; Ong, S.-Q.; Bjerge, K.; Carrillo, J.; Hoeye, T. T.; Geissmann, Q.

10.1101/2025.04.08.647223 — ecology — Posted on 2025-04-14

3013 Plant diversity promotes aboveground arthropods and associated functions despite arthropod loss over time

Ebeling, A.; Broecher, M.; Hertzog, L.; Schielzeth, H.; Weisser, W. W.; Meyer, S. T.

10.1101/2025.04.09.647912 — ecology — Posted on 2025-04-14

3014 Identification of Bone Morphogenic Protein (BMP15) gene at exons 1 and 2 in Indigenous, Mozaffornagri, and Dorper ram breeds of Bangladesh and its phylogenetic relationship with other breeds

Hasan, M. R.; Bari, F. Y.; Bhuiyan, M. M. U.; Juyena, N. S.

10.1101/2025.04.10.648142 — cell biology — Posted on 2025-04-14

3015 Failed Metabolic Adaptation to Stress Underlies Pathogenesis in a Heterozygous Genetic Disorder

Harmon, R.; McCarthy, E.; Krol, A.; Braun, J.; Shetti, A.; Godsel, L.; Ren, Z.; Perez-White, B.; Weinberg, S.; Simpson, C. L.; Dahl, R.; Goyal, Y.; Prakriya, M.; Cohen-Barak, E.; Dodiuk-Gad, R.; Paller, A. S.; Green, K. J.

10.1101/2025.04.13.648535 — cell biology — Posted on 2025-04-14

3016 Splicing factor SRSF1 is a pH-stat to restore nucleolar integrity and function

Ma, S.; Guo, J.; Zhan, X.; Yang, S.; Huang, C.; Wang, B.

10.1101/2025.04.12.648491 — cell biology — Posted on 2025-04-14

3017 The tumour suppressor LACTB remodels mitochondria to promotecytochrome c release and apoptosis

Kamerkar, S. C.; Kang, T.; Stan, R. V.; Usherwood, E. J.; Higgs, H.

10.1101/2025.04.12.648505 — cell biology — Posted on 2025-04-14

3018 A class of COPI adaptors regulates processing of transmembrane receptors by reinforcing their Golgi retention

Gao, J.; Cong, C.; Xiang, Y.; Wu, Y.; Yan, B.; Jia, Q.; Yao, Z.; Guo, Y.; Hu, J.

10.1101/2025.04.11.648407 — cell biology — Posted on 2025-04-14

3019 Proteasomal Dysfunction results in ER stress, Endo MT, oxidative stress, and apoptotic cell death resulting in Fuchs Corneal Endothelial Dystrophy like features in mice

Murugan, S.; Ghag, S. A.; Souza de Campos, V.; Pan, H.-Y.; Price, M. O.; Price, F. W.; Shyam, R.

10.1101/2025.04.11.648416 — cell biology — Posted on 2025-04-14

3020 K48-ubiquitin-activated proteases cut-up post-ER proteins

Minard, A. Y.; Winistorfer, S.; Yu, L.; Piper, R. C.

10.1101/2025.04.13.648637 — cell biology — Posted on 2025-04-14

3021 Airway Secretory Cells Contain Both a Perinuclear Golgi Ribbon and Dispersed Golgi Satellites

Hoang, O. N.; Chan, C. E.; brenner, j. m.; Leza-Rincon, D.; Jaramillo, A. M.; Dolan, B.; Aziz, A. W.; Cardenas, R. A.; Cardenas, G. J.; Galvez, E. D.; Powell, R. T.; Vergara, L.; Karmouty-Quintana, H.; Magnusson, J. M.; Hansson, G. C.; Adachi, R.; Dickinson, J. D.; Evans, C. M.; Courson, J. A.; Burns, A. R.; Tuvim, M. J.; Dickey, B.

10.1101/2025.04.11.648270 — cell biology — Posted on 2025-04-14

3022 Altered laminin signaling destinates melanocyte reprogramming in vitiligo

Yang, F.; Yang, L.; Lai, S.; Yokota, M.; Kuroda, Y.; Yuki, T.; Takahashi, Y.; Sayo, T.; Namiki, T.; Goto, H.; Hiroyasu, S.; Sano, S.; Inoue, S.; Mizukami, Y.; Tsuruta, D.; Katayama, I.

10.1101/2025.04.11.648350 — cell biology — Posted on 2025-04-14

3023 Spatial distribution of cytoskeleton-mediated feedback controls cell polarization: a computational study

Banerjee, P.; Kuhn, J.; Pal, D. S.; Deng, Y.; Banerjee, T.; Devreotes, P. N.; Iglesias, P. A.

10.1101/2025.04.12.648264 — cell biology — Posted on 2025-04-14

3024 A Role for Importin α in Ciliogenesis and Cilia Length Regulation during Nephrogenesis

Mosqueda, N.; Sutton, P. J.; Brownlee, C. W.

10.1101/2025.04.10.648263 — cell biology — Posted on 2025-04-14

3025 A mouse model of early sporadic tau pathology induces neurogenic plasticity in the hippocampus

Ash, A. M.; Baek, S. R.; Holder, P.; Vyleta, N. P.; Willman, M.; Nash, K. R.; Snyder, J. S.

10.1101/2025.04.08.647737 — neuroscience — Posted on 2025-04-14

3026 Mechanisms of long term non-reinforced preference change: functional connectivity changes in a longitudinal functional MRI study

Itzkovitch, A.; Oren, S.; Chopra, S.; Fornito, A.; Schonberg, T.

10.1101/2025.04.08.647732 — neuroscience — Posted on 2025-04-14

3027 ICE BINDING PROTEIN ACTIVITY IS COMMON AMONG TEMPERATE PACIFIC INTERTIDAL INVERTEBRATES

Moyes, N. H.; Bertram, A. K.; Marshall, K. E.

10.1101/2025.04.08.647825 — zoology — Posted on 2025-04-14

3028 Continuous accelerated rock weathering by marine bacteria with enhanced siderophore production

Dalvie, N. C.; Jalihal, A. P.; Böhnke, J.-T.; Justman, Q. A.; Silver, P. A.; Springer, M.

10.1101/2025.04.08.647837 — systems biology — Posted on 2025-04-14

3029 Molecular Mimicry Between Epstein-Barr Virus and Human Herpesvirus-6 Proteins and Central Nervous System Proteins: Implications for T and B Cell Immunogenicity in an In Silico Study.

Almulla, A. F.; Normatov, M. G.; Supasitthumrong, T.; Maes, M.

10.1101/2025.04.02.646883 — bioinformatics — Posted on 2025-04-14

3030 Convergent Evolution of H4K16ac-mediated Dosage Compensation Shapes Sex-dependent Lifespan in a ZW Species

Zimmer, F.; Fox, A. M.; Pan, Q.; Ruehle, F.; Andersen, P.; Huylmans, A.-K.; Schwander, T.; Basilicata, M. F.; Keller Valsecchi, C. I.

10.1101/2025.04.10.648168 — evolutionary biology — Posted on 2025-04-14

3031 PANoptosis, a combination of inflammatory cell death mechanisms, induced 1 by Ophiobolin A in breast cancer cell lines

Ranganathan, S.; Ojo, T.; Subramanian, A.; Tobin, J.; Haberman, K.; Kornienko, A.; Boari, A.; Evidente, A.; Benton, M. L.; Romo, D.; Taube, J.

10.1101/2025.04.08.647841 — cancer biology — Posted on 2025-04-14

3032 Combined quetiapine and radiation therapy approach to treat mesothelioma-initiating cells and increase survival in a mouse model of mesothelioma

Cardenas, A.; Arambula, E.; Azizi, L.; Lam, T.; Sutlief, S.; Bhat, K.; Saki, M.; He, L.; Pajonk, F.

10.1101/2025.04.08.647821 — cancer biology — Posted on 2025-04-14

3033 Curated and harmonised transcriptomics datasets of interstitial lung diseases

Inkala, S.; Federico, A.; Serra, A.; Greco, D.

10.1101/2025.04.08.647776 — bioinformatics — Posted on 2025-04-14

3034 The H3K27me3 reader UAD-2 recruits a TAF-12-containing transcription condensates to initiate piRNA expression within heterochromatic clusters

Huang, X.; Kuang, Y.; Li, M.; Hong, M.; Xu, D.; Cheng, J.; Huang, T.; Sun, X.; Wang, W.; Zhou, Y.; Feng, X.; Chen, X.; Zhu, C.; Guang, S.

10.1101/2025.04.11.648483 — genetics — Posted on 2025-04-14

3035 Modular regulation of the stem cell transcriptome defines self-renewal, differentiation, and dedifferentiation

Raz, A. A.; Hassan, H.; Yamashita, Y. M.

10.1101/2025.04.10.648217 — developmental biology — Posted on 2025-04-14

3036 Exogenous expression of a histone H3.3 isoform causes extranuclear divisions in the C. elegans intestine

Sandoval, C. H.; Borchers, C.; Osburn, K. L.; Boyd, B.; Aoki, S. T.

10.1101/2025.04.10.648275 — developmental biology — Posted on 2025-04-14

3037 Assessing the potential cardiovascular risk of microdosing the psychedelic LSD in mice

Effinger, D.; Schalk, S. S.; King, J. L.; Strong, J. R.; O'Connell, C. K.; Calderon, J. R.; McCorvy, J.; Thompson, S. M.

10.1101/2025.04.08.647757 — pharmacology and toxicology — Posted on 2025-04-14

3038 Ophiobolin A selectively alters mitochondria, metabolism and redox biology in breast cancer and mammary epithelial cells which have undergone epithelial to mesenchymal transition

Parker, H.; Tao, Y.; Tobin, J.; Haberman, K. L.; Davis, S.; York, E.; Martinez, A.; Matsumoto, N.; Aroujo, J.; Park, J.; Zechmann, B.; Kiapparettu, B. A.; Boari, A.; Sayes, C.; Evidente, A.; Kornienko, A.; Cravatt, B.; Romo, D.; Taube, J.

10.1101/2025.04.08.647828 — cancer biology — Posted on 2025-04-14

3039 Mucin anchoring of SARS-CoV-2 neutralizing nanobinders increases intranasal antiviral efficacy

Rocha Gomes, J.; Jacquelin, J.; Donchet, A.; Lejal, N.; Nevers, Q.; Konjkowski, B.; Le Poder, S.; Delmas, B.; MEUNIER, N.

10.1101/2025.04.10.648177 — microbiology — Posted on 2025-04-14

3040 Pleiotropic role of PAX cyclolipopeptides in the Xenorhabdus bacterium mutualistically associated with entomopathogenic nematodes

Claveyroles, N.; Lanois-Nouri, A.; El Fannassi, I.; Ogier, J.-c.; Pages, S.; Chouchou, A.; Cazals, G.; Valette, G.; Carre-Mlouka, A.; Givaudan, A.

10.1101/2025.04.11.648461 — microbiology — Posted on 2025-04-14

3041 Dissecting organoid-bacteria interaction highlights decreased contractile force as a key factor for heart infection

Wang, A.; wang, j.; zhang, z.; yang, c.; deng, c.; Chen, G.; Li, C.; wang, q.; Dong, L.; Wang, C.

10.1101/2025.04.08.647814 — bioengineering — Posted on 2025-04-14

3042 scContrast: A contrastive learning based approach for encoding single-cell gene expression data

Li, W. Y.; Murtaza, G.; Singh, R.

10.1101/2025.04.07.647292 — genomics — Posted on 2025-04-14

3043 Compression of functional gradients from rest to naturalistic processing: Moderation effect of age

Ye, S.; Mostert, J. C.; Pedersen, R.; Lan, X.; Zhao, L.; Salami, A.; Ziaei, M.

10.1101/2025.04.11.648387 — neuroscience — Posted on 2025-04-14

3044 Genetic and morphological analysis shows the Nechisar Nightjar is a hybrid

Shannon, T. J.; Van Grouw, H.; Collinson, J. M.

10.1101/2025.04.08.647728 — zoology — Posted on 2025-04-13

3045 LimbLab: Pipeline for 3D Analysis and Visualisation of Limb Bud Gene Expression

Avino Esteban, L.; Cardona-Blaya, H.; Musy, M.; Matyjaszkiewicz, A.; Sharpe, J.; Dalmasso, G.

10.1101/2025.04.08.647723 — bioinformatics — Posted on 2025-04-13

3046 SCARF: Single Cell ATAC-seq and RNA-seq Foundation model

Liu, G.; Zhao, Y.; Zhao, Y.; Wang, T.; Cai, Q.; Wang, X.; Wen, Z.; Lin, L.; Yang, G.; Chen, J.

10.1101/2025.04.07.647689 — bioinformatics — Posted on 2025-04-13

3047 Genome-wide association study in European beech (Fagus sylvatica L.) for drought stress traits

Tost, M.; Grigoriadou-Zormpa, O.; Wilhelmi, S.; Mueller, M.; Wildhagen, H.; Curtu, A. L.; Beissinger, T.; Gailing, O.

10.1101/2025.04.08.647712 — genetics — Posted on 2025-04-13

3048 Fitness Landscape Ruggedness Arises from Biophysical Complexity

Spence, M. A.; Sandhu, M.; Matthews, D. S.; Nichols, J.; Jackson, C. J.

10.1101/2025.04.12.648556 — evolutionary biology — Posted on 2025-04-13

3049 Single cell spatial proteomics maps human liver zonation patterns and their vulnerability to fibrosis

Weiss, C. A.; Brown, L. A.; Miranda, L.; Pellizzoni, P.; Ben-Moshe, S.; Steigerwald, S.; Remmert, K.; Hernandez, J.; Bogwardt, K.; Rosenberger, F. A.; Porat-Shliom, N.; Mann, M.

10.1101/2025.04.13.648568 — molecular biology — Posted on 2025-04-13

3050 Leveraging Bayesian Networks for Consensus Network Construction and Multi-Method Feature Selection to Decode Disease Prediction

Aghdam, R.; Shan, S.; Lankau, R.; Solis-Lemus, C.

10.1101/2025.04.07.647660 — systems biology — Posted on 2025-04-13

3051 Modular Engineering of Escherichia coli for Enhanced Nickel Uptake, Survival, Biomineralization, and Hydrogen-Supported Bioremediation

Shi, Y.; Ma, R.; Qi, L.; Tan, X.; Chen, L.; Wang, Y.; Huang, K.; Suo, Z.; Li, Y.; Chen, H.; Chen, Z.; Chen, X.; Li, W.; Zhen, K.

10.1101/2025.04.13.648562 — synthetic biology — Posted on 2025-04-13

3052 Protein Phosphatase 2A Subunit B55 Alpha is Required for Angiotensin Type 2 Receptor Elicited Natriuresis

Keller, S. R.; Gildea, J. J.; LI, J.; Kemp, B. A.; Conaway, M.; Brautigan, D. L.; Carey, R. M.; Howell, N.

10.1101/2025.04.07.647676 — physiology — Posted on 2025-04-13

3053 Novel Strategy against AML by Rescuing Loss of Phase Separation of Pathogenic NPM1c

Li, P.; Zhu, Y.; Xu, W.; Wang, R.; Hu, L.; HUANG, X.; Zhu, H.

10.1101/2025.04.08.646961 — cancer biology — Posted on 2025-04-13

3054 PI5P4Kα Regulates Iron Balance to Promote Metabolic Fitness in Pancreatic Cancer

Arora, G. K.; Loughran, R. M.; Ly, K.; Galapate, C. M.; Llorente, A.; Anderson, T. R.; Scott, D. A.; Altman, Y.; Murad, R.; Commisso, C.; Emerling, B. M.

10.1101/2025.04.07.647654 — cancer biology — Posted on 2025-04-13

3055 Dividing out quantification uncertainty enables assessment of differential transcript usage with diffSplice

Baldoni, P. L.; Chen, L.; Li, M.; Chen, Y.; Smyth, G. K.

10.1101/2025.04.07.647659 — bioinformatics — Posted on 2025-04-13

3056 PepPCBench is a Comprehensive Benchmark for Protein-Peptide Complex Structure Prediction with AlphaFold3

Zhai, S.; Zhao, H.; Wang, J.; Lin, S.; Liu, T.; Jiang, D.; Liu, H.; Kang, Y.; Yao, X.; Hou, T.

10.1101/2025.04.08.647699 — bioinformatics — Posted on 2025-04-13

3057 FetchM: Streamlining Genome and Metadata Integration for Microbial Comparative Genomics

Anik, T. A.

10.1101/2025.04.08.647722 — bioinformatics — Posted on 2025-04-13

3058 Evaluating gene representation in spatial transcriptomics across pre-designed panels

Seo, H.; Krawetz, R.

10.1101/2025.04.07.647642 — bioinformatics — Posted on 2025-04-13

3059 GLASS: A Graph Learning Algorithm for Screening Splice-Aware Alignments of Long-Read RNA-seq

Li, J.; Li, G.; Yu, T.

10.1101/2025.04.07.647681 — bioinformatics — Posted on 2025-04-13

3060 Pleiotropy accelerates tooth phenotypic and genomic evolution - An in silico study under the lens of development

Hagolani, P. F.; Semon, M.; Beslon, G.; Pantalacci, S.

10.1101/2025.04.11.648404 — evolutionary biology — Posted on 2025-04-13

3061 Symbiont virulence is a poor predictor of impacts on host population dynamics

Dziuba, M. K.; McIntire, K. M.; Davenport, E. S.; Corcoran, F. E.; Nelson, T.; McCreadie, P.; Manuel, R. T.; Baird, E.; Dos Santos, N. F.; Robbins, M.; Dismondy, E.; Monell, K. J.; Huerta, C.; Selter, L. C.; Deckelbaum, K.; Cortez, M. H.; Duffy, M. A.

10.1101/2025.04.10.648206 — ecology — Posted on 2025-04-13

3062 Omnivorous diets of sympatric duck species in a subtropical East Asia wetland unveiled by multi-marker DNA metabarcoding

Huang, P.-Y.; Poon, E. S. K.; Chan, L. Y.; Lam, D. K.; So, I. W. Y.; Sung, Y.-H.; Sin, S. Y. W.

10.1101/2025.04.07.647698 — ecology — Posted on 2025-04-13

3063 Spatial patterning of contractility by a mechanogen gradient underlies Drosophila gastrulation

Mundhe, G.; Dunsing-Eichenauer, V.; Philippe, J.-M.; Da Silva, E.; Collinet, C.; Lecuit, T.

10.1101/2025.04.11.648359 — developmental biology — Posted on 2025-04-13

3064 The PBAF chromatin remodeling complex contributes to metal homeostasis through Mtf1 regulation

Carulli, N.; Johnston, E.; Klein, D. C.; Verdejo-Torres, O.; Parikh, A.; Rivera, A.; Quinteros, M.; Pezacki, A. T.; Chang, C. J.; Hainer, S. J.; PADILLA-BENAVIDES, T.

10.1101/2025.04.12.648552 — molecular biology — Posted on 2025-04-13

3065 Analysis of Treacher Collins syndrome 4-associated mutations in Schizosaccharomyces pombe

Kawakami, K.; Kato, H.

10.1101/2025.04.13.648503 — molecular biology — Posted on 2025-04-13

3066 Zinc ions inactivate influenza virus hemagglutinin and prevent receptor binding

Jeong, A. Y.; Gopal, V.; te Velthuis, A. J. W.

10.1101/2025.04.13.648591 — microbiology — Posted on 2025-04-13

3067 Response of Escherichia coli chemotaxis pathway to pyrimidine deoxyribonucleosides

Shah, M.; Sourjik, V.

10.1101/2025.04.13.648572 — microbiology — Posted on 2025-04-13

3068 Proteolytically activated antibacterial toxins inhibit the growth of diverse Gram-positive bacteria

Colautti, J.; Garrett, S. R.; Whitney, J. C.

10.1101/2025.04.13.648598 — microbiology — Posted on 2025-04-13

3069 Decoding Antimicrobial Resistance: Fusing Biologic Acumen and Computational Virtuosity for Paradigmatic Drug Innovation

Ananthoju, R.; Reddy, P. K.

10.1101/2025.04.13.648583 — microbiology — Posted on 2025-04-13

3070 Phenotypic Antibiotic Susceptibility Testing at the limit of one bacterial cell

Ahmad, I.; Johansson, L.; Larsson, J.; Zikrin, S.; Knagge, P.; Fange, D.; Elf, J.

10.1101/2025.04.13.648565 — microbiology — Posted on 2025-04-13

3071 Improved in silico and in vitro methods for E. coli LPS outer core typing

Trofimova, E.; Westerman, R. P.; Jaschke, P. R.

10.1101/2025.04.13.648558 — microbiology — Posted on 2025-04-13

3072 Tissue-specific improvements in CD4+ T cell responses after treatment for visceral leishmaniasis.

Engel, J. A.; Rivera, F.; Crawford, B.; Lee, H. J.; Na, J.; Chang, K.; Gartlan, K.; Bukali, L.; Frame, T.; Wang, Y.; Haque, A.; Engwerda, C.; Engwerda, C.

10.1101/2025.04.13.648617 — immunology — Posted on 2025-04-13

3073 Tissue-wide profiling of human lungs reveals spatial sequestration of macrophages in tuberculosis

Xiao, W.; Sawyer, A. J.; Mo, S.; Bai, X.; Yang, Q.; Gao, Y.; Fielder, T.; Zhang, Y.; Dai, Y.; Yang, Q.; Cai, Y.; Ding, G.; Deng, G.; Fu, L.; Quek, C.; Wilmott, J.; Palendira, U.; Britton, W.; Barber, D. L.; Ernst, J. D.; Patrick, E.; Feng, C.; Chen, X.

10.1101/2025.04.11.648467 — immunology — Posted on 2025-04-13

3074 Exosomal cargo genes as biomarkers and potential mediators of exosome-driven cell communication in Pleural Mesothelioma

Kraft, A.; Toenz, A.; Schlaepfer, F.; Ronner, M.; Orlowski, V.; Kirschner, M. B.; Felley-Bosco, E.; Bein, J.; Wild, P. J.; Boeva, V.; Opitz, I.; Meerang, M.

10.1101/2025.04.04.647264 — cancer biology — Posted on 2025-04-13

3075 Post-transcriptional regulator HuR promotes immune evasion in pancreatic ductal adenocarcinoma

Guo, Y.; Finan, J. M.; Bartlett, A. Q.; Sivagnanam, S.; Blise, K. E.; Kirchberger, N.; Betre, K.; McCarthy, G. A.; Hawthorne, K.; Chen, C.; Grossberg, A.; Xia, Z.; Coussens, L. M.; Sears, R. C.; Brody, J. R.; Eil, R.

10.1101/2025.02.07.632847 — cancer biology — Posted on 2025-04-13

3076 Scratching in Style: 3D Printers as Plotters for Automated and Complex Wound Healing Assays

Köppe, H.; Richert, M. G.; Singer, D.; Köppe, J.; Köppe, M.; Tzvetkov, M.; Schroeder, H. W. S.; Bekeschus, S.; Bien-Möller, S.

10.1101/2024.09.19.613824 — bioengineering — Posted on 2025-04-13

3077 Comparison of Activities of Transcription Factor NF-κB from Two Jellyfish Models

Williams, L. M.; Wang, W.; Grigoryeva, A. V.; Navarro-Rosado, A.; Peart, J. A.; Calderon, A.; Gill, C. L.; Black, S.; Alsante, K. M.; Lackstrom, A. T.; Molecular Biology Laboratory, ; Weissbourd, B.; Wang, M.; DiRusso, C. J.; Cohen, L. B.; Wunderlich, Z.; Grone, B. P.; Gilmore, T. D.

10.1101/2025.01.21.634164 — molecular biology — Posted on 2025-04-13

3078 Induction of hemodynamic traveling waves by glial-related vasomotion in a rat model of neuroinflammation: implications for functional neuroimaging

Pereira, M.; Droguerre, M.; Valdebenito, M.; Vidal, L.; Marcy, G.; Benkeder, S.; Marchal, P.; Comte, J.-C.; Pascual, O.; Zimmer, L.; VIDAL, B.

10.1101/2024.12.13.628348 — neuroscience — Posted on 2025-04-13

3079 A systematic review of professional society-backed biology education DEI research: The groups, research methods, and levels of analyses comprising the field

Idlebird, C.; Campbell-Montalvo, R.; McDowell, G. S.; Blosser, E.; Harvey, R.; Marcette, J.

10.1101/2024.09.19.613887 — scientific communication and education — Posted on 2025-04-13

3080 Trichoderma afroharzianum T22 induces rhizobia and flavonoid-driven symbiosis to promote tolerance to alkaline stress in garden pea

Thapa, A.; Hasan, M. R.; Kabir, A. H.

10.1101/2024.07.11.603139 — plant biology — Posted on 2025-04-13

3081 Relaxin signaling is critical for virgin female reproductive physiology in Drosophila

Volonte, Y.; Heredia, F.; Zanini, R.; Menezes, J.; Perez, M. S.; Gualdino, M.; Lage, L.; Cruz, L. d. S.; Casimiro, A. P.; Garelli, A.; Gontijo, A. M.

10.1101/2025.04.03.647069 — physiology — Posted on 2025-04-13

3082 Water-mediated interactions between glycans are weakly repulsive and unexpectedly long-ranged

Shin, S.; Mugnai, M. L.; Thirumalai, D.

10.1101/2025.02.16.638483 — biophysics — Posted on 2025-04-13

3083 PS Poly: A chain tracing algorithm to determine persistence length and categorize complex polymers by shape

Conley, E. A.; Lisowski, C. M.; Schaefer, K. G.; Davison, H. C.; Baguio, J.; Kosztin, I.; King, G.

10.1101/2024.05.06.592664 — biophysics — Posted on 2025-04-13

3084 A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality.

Krishnan, S.; Dong, C.; Ratigan, H.; Morales-Rodriguez, D.; Cherian, C.; Sheffield, M.

10.1101/2024.11.26.625482 — animal behavior and cognition — Posted on 2025-04-13

3085 Precise and scalable metagenomic profiling with sample-tailored minimizer libraries

Nystrom-Persson, J.; Bapatdhar, N.; Ghosh, S.

10.1101/2024.12.22.629657 — genomics — Posted on 2025-04-13

3086 Genotyping sequence-resolved copy number variationusing pangenomes reveals paralog-specific global diversityand expression divergence of duplicated genes

Ma, W.; Chaisson, M.

10.1101/2024.08.11.607269 — genomics — Posted on 2025-04-13

3087 A fractal pattern of hierarchical genetic population structure in mixed stocks across fish segregated by dams revealed by genomic resources for curimba Prochilodus lineatus

Yazbeck, G. M.; Nascimento, G. A. S.; Carvalho, L. C.; Graciano, R. C. D.; Santos, R.; Oliveira, R. S.

10.1101/2025.03.14.643328 — genetics — Posted on 2025-04-13

3088 Early versus late noise differentially enhances or degrades context-dependent choice

Shen, B.; Nguyen, D.; Wilson, J. M.; Glimcher, P. W.; Louie, K.

10.1101/2024.03.26.586597 — neuroscience — Posted on 2025-04-13

3089 Anterior cingulate cortex mixes retrospective cognitive signals and ongoing movement signatures during decision-making

Oesch, L. T.; Thomas, M. C.; Sandberg, D.; Couto, J.; Churchland, A. K.

10.1101/2025.04.11.648398 — neuroscience — Posted on 2025-04-13

3090 Attuning to song duels facilitates song-matching in nightingales

Costalunga, G.; Carpena Sanchez, C.; Benichov, J. I.; Cross, C.; Clemens, J.; Vallentin, D.

10.1101/2025.04.12.648496 — neuroscience — Posted on 2025-04-13

3091 Nightingales imitate the duration of whistle syllables

Calderon Garcia, J. S.; Costalunga, G.; Vogels, T. P.; Vallentin, D.

10.1101/2025.04.12.648498 — animal behavior and cognition — Posted on 2025-04-13

3092 Storage stability of non-encapsulated pneumococci in saliva is dependent on null-capsule clade, with strains carrying aliC and aliD showing a competitive disadvantage during culture enrichment

Laxton, C. S.; Allicock, O. M.; Peno, C.; Lin, T.-Y.; Koelewijn, A. M.; Toekiran, F. L.; Aguilar, L.; York, A.; Wyllie, A. L.

10.1101/2025.04.12.648276 — microbiology — Posted on 2025-04-13

3093 Stress Granule Formation Drives ZBP1-dependent Necroptosis in Non-obstructive Azoospermia and Aging testes

Lei, H.; Li, D.; Chen, J.; Du, B.; Jiang, K.; Xu, T.; Han, H.; Fan, W.; Tian, L.; Wang, X.

10.1101/2025.04.11.648478 — molecular biology — Posted on 2025-04-12

3094 Identification of Injury-Response State Determinants in Glioblastoma Stem Cells

Molaei, F.; MacLeod, G.; Haider, S.; Tiffany, A.; Oteng, F. M.; Berman, J. M.; Skirzynska, A.; Shoichet, M. S.; Schramek, D.; Dirks, P. B.; Angers, S.

10.1101/2025.04.07.647626 — cancer biology — Posted on 2025-04-12

3095 Matrix Stiffness Regulates Mechanotransduction and Vascular Network Formation of hiPSC-Derived Endothelial Progenitors Encapsulated in 3D Hydrogels

Han, J.; Halwachs, K. N.; West, T.; Larsen, B. V.; Sacks, M. S.; Rosales, A.; Zoldan, J.

10.1101/2025.04.11.648340 — bioengineering — Posted on 2025-04-12

3096 HIV-1 Nef uses a conserved pocket to recruit the N-terminal cytoplasmic tail of Serinc3

Karimian Shamsabadi, M.; Stoneham, C.; De-leon, A.; Fares, T.; Guatelli, J.; Jia, X.

10.1101/2025.04.12.648528 — biochemistry — Posted on 2025-04-12

3097 The Response Regulator BqsR/CarR Controls Ferrous Iron (Fe2+) Acquisition in Pseudomonas aeruginosa

Paredes, A.; Singh, H.; Hull, M. T.; Greene, D.; Northrup, A. J.; Brown, J. B.; Chacon, K. N.; Patrauchan, M. A.; Smith, A. T.

10.1101/2025.04.12.648518 — biochemistry — Posted on 2025-04-12

3098 GLUT4 translocation with insulin: revisiting the case for dose-dependent quantal release

Romenskaia, I.; Mastick, C. C.; Coster, A.

10.1101/2025.04.11.648479 — biochemistry — Posted on 2025-04-12

3099 Highly sensitive chemiluminescence imaging of misfolded proteins in neurodegenerative models

Zhu, B.; Van, R.; Wang, H.; Kuang, S.; Jia, Y.; Leon, E. C.; Yang, F.; Zhang, J.; Yang, J.; Hong, H.; Fleur Marie, L.; Yu, A.; Wang, J.; Tanzi, R. E.; Zhang, C. M.; Mao, X. M.; Shao, Y.; Ran, C.

10.1101/2025.04.12.648090 — biochemistry — Posted on 2025-04-12

3100 The proofreading mechanism of the human leading strand DNA polymerase ϵ holoenzyme

Wang, F.; He, Q.; O'Donnell, M. E.; Li, H.

10.1101/2025.04.11.648458 — biochemistry — Posted on 2025-04-12

3101 A DNA methylation-based clock for age estimates in the wood mouse (Apodemus sylvaticus)

Wolf, S. E.; Babayan, S. A.; Marioni, R. A.; Chandra, T.; Horvath, S.; Little, T. J.; Pedersen, A. B.

10.1101/2025.04.09.648041 — genomics — Posted on 2025-04-12

3102 First national survey of terrestrial biodiversity using airborne eDNA

Tournayre, O.; Littlefair, J. E.; Garrett, N. R.; Allerton, J. J.; Brown, A. S.; Cristescu, M. E.; Clare, E. L.

10.1101/2025.04.07.647580 — ecology — Posted on 2025-04-12

3103 Continental-scale relationships of fine root and soil carbon stocks hold in grasslands but not forests

Malhotra, A.; Moore, J. A. M.; Weintraub-Leff, S.; Georgiou, K.; Berhe, A. A.; Billings, S. A.; de Graaff, M.-A.; Fraterrigo, J. M.; Grandy, A. S.; Kyker-Snowman, E.; Lu, M.; Meier, C.; Pierson, D.; Tumber-Davila, S. J.; Lajtha, K.; Wieder, W. R.; Jackson, R. B.

10.1101/2025.04.07.647629 — ecology — Posted on 2025-04-12

3104 Deaminase-based RNA recording enables high throughput mutational profiling of protein-RNA interactions

Bakker, R. A.; Nicholson, O. B.; Park, H.; Subramaniam, A. R.; Lapointe, C. P.

10.1101/2025.04.11.648485 — molecular biology — Posted on 2025-04-12

3105 Cadmium-induced gut dysbiosis precedes the onset of hippocampus-dependent learning and memory deficits in mice

Wang, H.; Lim, J. J.; Gu, H.; Xia, Z.; Cui, J. Y. Y.

10.1101/2025.04.07.647608 — systems biology — Posted on 2025-04-12

3106 AutoLEI: An XDS-based Graphical User Interface for Automated Real-time and Offline Batch 3D ED/MicroED Data Processing

Wang, L.; Chen, Y.; Scaletti Hutchinson, E.; Stenmark, P.; Hofer, G.; Xu, H.; Zou, X.

10.1101/2025.04.12.648515 — molecular biology — Posted on 2025-04-12

3107 Plant host identity drives Andropogon gerardii rhizobiome assembly strategies under increasing abiotic stress

Vogt, B. M.; Kazarina, A.; Sytsma, J.; Adams, B.; Rodela, L.; Clouse, D.; Keller, R.; Thompson, D.; Winters, H.; Wagner, M.; Baer, S.; Jumpponen, A. M.; Johnson, L.; Lee, S. T. M.

10.1101/2025.04.12.648431 — microbiology — Posted on 2025-04-12

3108 Laboratory transmission of Adult Salmon Enteritis and associated pathogens in juvenile Chinook Salmon (Oncorhynchus tshawytscha)

Polley, T. M.; Couch, C.; Leong, C.; Peterson, J. T.; Weiss, L. M.; Takvorian, P. M.; Kent, M.

10.1101/2025.04.07.647091 — pathology — Posted on 2025-04-12

3109 An analysis of free energy methods to quantify and displace the KRasG12D Thr58 water

Dickson, C. J.

10.1101/2025.04.12.648534 — biochemistry — Posted on 2025-04-12

3110 The conserved SEN1 DNA/RNA helicase has multiple functions during yeast meiosis

Gaglione, R.; Caradonna, J.; MacQueen, A. J.; Luk, E.; Hollingsworth, N. M.

10.1101/2025.04.10.648140 — genetics — Posted on 2025-04-12

3111 TRPV1 Defends the Healthy Murine Cornea against Staphylococcus aureus Adhesion Independently of Sensory Nerve Firing

Flandrin, O.; Yang, Y.; Abboud, S.; Kumar, N. G.; Datta, A.; Bautista, D. M.; Evans, D. J.; Fleiszig, S. M. J.

10.1101/2025.04.12.648450 — microbiology — Posted on 2025-04-12

3112 Effect of spatial overdispersion on confidence intervals for population density estimated by spatial capture-recapture

Efford, M. G.; Fletcher, D.

10.1101/2024.03.12.584742 — ecology — Posted on 2025-04-12

3113 Sp140L Is a Novel Herpesvirus Restriction Factor

Cable, J. M.; Wongwiwat, W.; Grabowski, J.; White, R. E.; Luftig, M. A.

10.1101/2024.12.13.628399 — microbiology — Posted on 2025-04-12

3114 Extracellular Vesicles from hiPSC-derived NSCs Protect Human Neurons against Abeta-42 Oligomers Induced Neurodegeneration, Mitochondrial Dysfunction and Tau Phosphorylation

Rao, S.; Madhu, L. N.; Babu, R. S.; Shankar, G.; Kotian, S.; Nagarajan, A.; Upadhya, R.; Narvekar, E.; Cai, J. J.; Shetty, A. K.

10.1101/2024.07.11.603159 — neuroscience — Posted on 2025-04-12

3115 Improving AlphaFold2 and 3-based protein complex structure prediction with MULTICOM4 in CASP16

Liu, J.; Neupane, P.; Cheng, J.

10.1101/2025.03.06.641913 — bioinformatics — Posted on 2025-04-12

3116 Construction of Accurate Turtle Cerebellum Models and their use in Simulating Neuromodulation using the BEM-FMM

Noetscher, G.; Small-Zlochower, S.; Sundaram, P.; Makaroff, S. N.

10.1101/2025.04.08.647756 — neuroscience — Posted on 2025-04-12

3117 A ketogenic diet mitigates hippocampal astrogliosis in epileptic brain

Choi, J. H.; Kim, H.; Wang, S.; Cai, Y.; Achanta, A.; Pamujula, S.; Thange, H. M.; Shtrahman, M.; Rho, J. M.

10.1101/2025.04.11.647636 — neuroscience — Posted on 2025-04-12

3118 Local nesting resources rather than floral food alter ground-nesting bee communities in grazed habitats

Collins, S. M.; Taylor, L. A.; Wright, K. W.; Lichtenberg, E. M.

10.1101/2024.08.19.608671 — ecology — Posted on 2025-04-12

3119 EEG-based Assessment of Long-Term Vigilance and Lapses of Attention using a User-Centered Frequency-Tagging Approach

Ladouce, S.; Torre-Tresols, J. J.; Le Goff, K.; Dehais, F.

10.1101/2024.12.12.628208 — neuroscience — Posted on 2025-04-12

3120 CoDIAC: A comprehensive approach for interaction analysis reveals novel insights into SH2 domain function and regulation

Kandoor, A.; Martinez, G.; Hitchcock, J. M.; Angel, S.; Campbell, L.; Rizvi, S.; Naegle, K. M.

10.1101/2024.07.18.604100 — systems biology — Posted on 2025-04-12

3121 Aboveground fungal lethal effects of local plants on invasive plant Ageratina adenophora seedlings

Zeng, Z.-Y.; Liu, Z.-Q.; Yang, A.-L.; Li, Y.-X.; Wang, Y.-L.; Siemann, E.; Li, B.; Zhang, H.-B.

10.1101/2025.01.21.634076 — ecology — Posted on 2025-04-12

3122 IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models

10.1101/2024.04.01.587634 — cancer biology — Posted on 2025-04-12

3123 Resilience and vulnerabilities of tumor cells under purine shortage stress

Yu, J.; Jin, C.; Su, C.; Moon, D.; Sun, M.; Zhang, H.; Jiang, X.; Zhang, F.; Tserentsoodol, N.; Bowie, M. L.; Pirozzi, C. J.; George, D. J.; Wild, R.; Gao, X.; Ashley, D. M.; He, Y.; Huang, J.

10.1101/2025.03.19.644180 — cancer biology — Posted on 2025-04-12

3124 A Spatial Multi-Omic Framework Identifies Gliomas Permissive to TIL Expansion

Hotchkiss, K. M.; Zhang, K.; Corcoran, A. M.; Owens, E.; Noldner, P.; Railton, C.; Van Batavia, K.; Zhou, Y.; Jepson, J.; Singh, K.; McLendon, R.; Batich, K.; Patel, A. P.; Ayasoufi, K.; Brown, M. C.; Calabrese, E.; Xie, J.; Conejo-Garcia, J.; Shaz, B. H.; Hickey, J. W.; Khasraw, M.

10.1101/2025.03.26.645566 — cancer biology — Posted on 2025-04-12

3125 Single-cell Growth Rate Variability in Balanced Exponential Growth

Biswas, K.; Sanderson, A. E.; Salman, H.; Brenner, N.

10.1101/2024.06.23.600237 — biophysics — Posted on 2025-04-12

3126 T-cell receptor sequences correlate with and predict gene expression levels in T cells

Wang, H.; Ji, Z.

10.1101/2023.11.27.568912 — bioinformatics — Posted on 2025-04-12

3127 VegVault database: linking global paleo-, and neo-vegetation data with functional traits and abiotic drivers

Mottl, O.; Gaiser, F.; Simova, I.; Flantua, S.

10.1101/2025.01.31.635213 — ecology — Posted on 2025-04-12

3128 Mapping the canine microbiome: Insights from the Dog Aging Project

Bamberger, T.; Muller, E.; Algavi, Y. M.; Greenier, A.; Adjangba, C.; Slikas, E.; Brassington, L.; Mariner, B.; McCoy, B.; Harrison, B. R.; Partida-Aguilar, M.; Marye, A.; Harris, A.; Rout, E.; DAP Consortium, ; Avery, A.; Promislow, D. E. L.; Snyder-Mackler, N.; Borenstein, E.

10.1101/2024.12.02.625632 — microbiology — Posted on 2025-04-12

3129 IFIT3 RNA-binding activity promotes influenza A virus infection and translation efficiency

Sullivan, O. M.; Nesbitt, D. J.; Schaack, G. A.; Feltman, E.; Nipper, T.; Kongsomros, S.; Reed, S. G.; Nelson, S. L.; King, C. R.; Shishkova, E.; Coon, J. J.; Mehle, A.

10.1101/2025.02.17.638785 — microbiology — Posted on 2025-04-12

3130 Self-Supervised Grid Cells Without Path Integration

Pettersen, M.; Schoyen, V. S.; Ostby, M. D.; Malthe-Sorenssen, A.; Lepperod, M. E.

10.1101/2024.05.30.596577 — neuroscience — Posted on 2025-04-12

3131 Dominance modifiers at the Arabidopsis self-incompatibility locus retain proto-miRNA features and act through non-canonical pathways

Batista, R. A.; Durand, E.; Mörchen, M.; Azevedo-Favory, J.; Simon, S.; Dubin, M.; Kumar, V.; Lacoste, E.; Cruaud, C.; Blassiau, C.; Barois, M.; Holl, A.-C.; Ponitzki, C.; Faure, N.; Marande, W.; Vautrin, S.; Fobis-Loisy, I.; Aury, J.-M.; Legrand, S.; Krämer, U.; Lagrange, T.; Vekemans, X.; Castric, V.

10.1101/2024.05.01.591913 — plant biology — Posted on 2025-04-12

3132 Reduced occurrence of alpha waves during resting state predicts high ADHD traits in young adults

Rodriguez Larios, J.; Aydin, U.; McLoughlin, G.

10.1101/2025.04.11.648375 — neuroscience — Posted on 2025-04-11

3133 The differential effect of glutamine supplementation on the orthotopic and subcutaneous growth of two syngeneic murine models of glioma

Maurer, J.; Mukherjee, P.; Ta, N.; Lee, D. C.; Duraj, T.; Henao, J.; Kiebish, M.; Van Cura, D.; Herdocia, M.; Seyfried, T. N.

10.1101/2025.04.07.647607 — cancer biology — Posted on 2025-04-12

3134 Dual Targeting for Enhanced Tumor Immunity: Conditionally Active CD28xVISTA Bispecific Antibodies Promote Myeloid-Driven T-Cell Activation

Thisted, T.; Smith, F. D.; Jiang, Z.-G.; Onumajuru, A.; Biesova, Z.; Kleschenko, Y.; Malhotra, K.; Saxena, V.; Mukherjee, A.; van der Horst, E. H.

10.1101/2025.04.07.647657 — cancer biology — Posted on 2025-04-12

3135 Metabolic buffering suppresses phenotype switching in cancer

Ramirez-Sanchez, A.; Jociles-Ortega, M.; Garcia-Martinez, J. M.; Torrens-Martinez, I.; Martinez-Useros, J.; Fernandez-Acenero, M. J.; Olmos-De Blas, T.; Louphrasitthiphol, P.; Goding, C. R.; Garcia-Jimenez, C.; Chocarro-Calvo, A.

10.1101/2025.04.07.647576 — cancer biology — Posted on 2025-04-12

3136 SpatioCell: A Deep Learning Algorithm for High-resolution Single-cell Mapping through Deep Integration of Histology Image and Sequencing Data

Hou, N.; Wu, Z.; Yu, Y.; Zhang, Y.; Wu, J.; Zhong, Z.; Xu, F.; Wang, Z.; Yang, C.; Tan, W.; Song, J.

10.1101/2025.04.07.647590 — bioinformatics — Posted on 2025-04-12

3137 Mapping brain function underlying naturalistic motor observation and imitation using high-density diffuse optical tomography

Yang, D.; George, T.; Sobolewski, C.; McMorrow, S.; Pacheco, C.; King, K.; Rochowiak, R.; Daniels-Day, E.; Park, S.; Speh, E.; Crocetti, D.; Nebel, M. B.; Tuncgenc, B.; Vidal, R.; Marrus, N. M.; Mostofsky, S. H.; Eggebrecht, A. T.

10.1101/2025.01.21.634109 — neuroscience — Posted on 2025-04-12

3138 Inferring genotype-phenotype maps using attention models

Rijal, K.; Holmes, C. M.; Petti, S.; Reddy, G.; Desai, M. M.; Mehta, P.

10.1101/2025.04.11.648465 — genetics — Posted on 2025-04-11

3139 Associations between symptom severity in Autism and functional neuroimaging measures of audiovisual speech perception.

Ross, L. A.; Molholm, S. A.; Foxe, J. J.

10.1101/2025.04.11.648437 — neuroscience — Posted on 2025-04-11

3140 Systematic modulation of sensorimotor learning by domain-specific working memory

O'Bryan, S. R.; Liddy, J. J.; Song, J.-H.

10.1101/2025.04.11.648414 — neuroscience — Posted on 2025-04-11

3141 Vowel-like patterns modulate auditory P100m response but not its association with language abilities in children with ASD

Fadeev, K. A.; Romero Reyes, I. V.; Goiaeva, D. E.; Obukhova, T. S.; Ovsiannikova, T. M.; Prokofyev, A. O.; Rytikova, A. M.; Novikov, A. Y.; Stroganova, T. A.; Orekhova, E. V.

10.1101/2025.04.10.648101 — neuroscience — Posted on 2025-04-11

3142 A common framework for semantic memory and semantic composition

Law, R. M. C.; Hauk, O.; Lambon Ralph, M.

10.1101/2025.04.11.648390 — neuroscience — Posted on 2025-04-11

3143 The molecular and cellular underpinnings of human brain lateralization

Labache, L.; Chopra, S.; Zhang, X.-H.; Holmes, A. J.

10.1101/2025.04.11.648388 — neuroscience — Posted on 2025-04-11

3144 Rapid prey capture learning drives a slow resetting of network activity in rodent binocular visual cortex

Leman, D. P.; Cary, B. A.; Bissen, D.; Lane, B. J.; Shanley, M. R.; Wong, N. F.; Bhut, K. B.; Turrigiano, G. G.

10.1101/2025.04.11.648036 — neuroscience — Posted on 2025-04-11

3145 Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation

Wang, Y.; Rattner, A.; Li, Z.; Smallwood, P. M.; Nathans, J.

10.1101/2025.04.11.648449 — neuroscience — Posted on 2025-04-11

3146 Shift augmentation improves DNA convolutional neural network indel effect predictions

Korsakova, A.; Srivastava, D.; Kelley, D. R.

10.1101/2025.04.07.647656 — genomics — Posted on 2025-04-11

3147 Dissecting the genetic basis of drought escape across multiple traits in colonizing Arabidopsis thaliana lineages

Elfarargi, A. F.; Gilbault, E.; Doring, N.; Dinis, H.; Weber, A. P. M.; Loudet, O.; Hancock, A. M.

10.1101/2025.04.07.647068 — genomics — Posted on 2025-04-11

3148 Arabidopsis CNL receptor SUT1 confers immunity in hydathodes against the vascular pathogen Xanthomonas campestris pv. campestris

Taks, N. W.; van Hulten, M.; van Splunter-Berg, J. A.; Chatterjee, S.; Stevens, F. D.; Paauw, M.; Pfeilmeier, S.; van den Burg, H. A.

10.1101/2024.06.20.599835 — plant biology — Posted on 2025-04-11

3149 Highly Multiplexed 3D Profiling of Cell States and Immune Niches in Human Tumours

Yapp, C.; Nirmal, A. J.; Zhou, F. Y.; Wong, A. Y. H.; Tefft, J.; Lu, Y. D.; Shang, Z.; Maliga, Z.; Montero Llopis, P.; Murphy, G. F.; Lian, C.; Danuser, G.; Santagata, S.; Sorger, P. K.

10.1101/2023.11.10.566670 — cancer biology — Posted on 2025-04-11

3150 Alpha-BET: Functional labeling of envelope glycoproteins with single domain antibodies for in-virus single molecule imaging

Williamson, D. J.; Zaza, C.; Carlon Andres, I.; Gentili, A.; Daly, J. I.; Holmes, H.; Thrush, J.; Starling, T.; Neil, S.; Owens, R.; Malim, M. M.; Tynan, C.; Simoncelli, S.; Padilla-Parra, S.

10.1101/2025.04.11.648405 — biophysics — Posted on 2025-04-11

3151 A High-Performance and Recoverable DNA Origami Rotary Motor

Shapira, H.; Sheheade, B.; Basak, S.; Khara, D.; Nir, E.

10.1101/2025.04.04.645735 — biophysics — Posted on 2025-04-11

3152 James-Stein estimator improves accuracy and sample efficiency in human kinematic and metabolic data

Alwan, A.; Srinivasan, M.

10.1101/2024.10.07.616339 — biophysics — Posted on 2025-04-11

3153 A genotype-phenotype transformer to assess and explain polygenic risk

Lee, I.; Wallace, Z.; Wang, Y.; Park, S.; Nam, H.; Majithia, A.; Ideker, T.

10.1101/2024.10.23.619940 — bioinformatics — Posted on 2025-04-11

3154 The Role of Ribose Modifications on the Structural Stability of Nucleotide Analogs with α-thiotriphosphate at the Active Site of SARS-CoV-2 RdRp

Li, Y.; Yuan, S.

10.1101/2025.04.11.648322 — bioinformatics — Posted on 2025-04-11

3155 PERSEUcpp: A machine learning strategy to predictcell-penetrating peptides and their uptake efficiency

Loch, R. M.; Almeida, G. O.; Brasiliano, I.; meira, W.; Montanha, D.; Baracat, C.; Silveira, S.

10.1101/2025.04.07.647598 — bioinformatics — Posted on 2025-04-11

3156 Influence of Macrocyclization Strategies on DNA-Encoded Cyclic Peptide Libraries

Zhao, H.; Li, X.; Yao, X.; Zhang, S.; Bao, Y.; Lu, W.; Xing, M.; Wang, X.; Wang, X.; Zhao, Y.; Chu, Q.; Lu, X.

10.1101/2025.04.10.648295 — biochemistry — Posted on 2025-04-11

3157 Computational Design of Metallohydrolases

Kim, D.; Woodbury, S. M.; Ahern, W.; Tischer, D.; Hanikel, N.; Salike, S.; Yim, J.; Pellock, S. J.; Lauko, A.; Kalvet, I.; Hilvert, D.; Baker, D.

10.1101/2024.11.13.623507 — biochemistry — Posted on 2025-04-11

3158 The β-amyloid oligomer Aβ*56 is associated with Alzheimer's dementia independently of amyloid pathology

Lapcinski, I. P.; Petersen, A. J.; Ashe, K. H.; Liu, P.

10.1101/2025.04.11.648457 — biochemistry — Posted on 2025-04-11

3159 In vitro Activity of Citrus IntegroPectin against Breast Cancer and Colon Cancer

D'Anna, C.; Di Sano, C.; Li Petri, G.; Angellotti, G.; Ciriminna, R.; Pagliaro, M.

10.1101/2025.04.11.648349 — biochemistry — Posted on 2025-04-11

3160 Backyard proteomics: A case study with the black widow spider

Shah, T.; Fitzpatrick, J. A.; Orsburn, B. C.

10.1101/2025.04.11.648442 — biochemistry — Posted on 2025-04-11

3161 An autism spectrum disorder mutation in Topoisomerase 3B causes accumulation of covalent mRNA intermediates by disrupting metal binding within the zinc finger domain

Warrick, J. E.; Attili, D.; van Eeuwen, T.; Hoffmann-Weitsman, S. E.; Forsyth, N. C.; Barmada, S. J.; Kearse, M. G.

10.1101/2025.04.11.647616 — biochemistry — Posted on 2025-04-11

3162 Ancient pangenomic origins of noncanonical NLR genes underlying the recent evolutionary rescue of a staple crop

VanGessel, C. J.; Felderhoff, T. J.; Prigozhin, D. M.; Cui, M.; Pressoir, G.; Healey, A. L.; Lovell, J. T.; Nalam, V. J.; Nishimura, M. T.; Morris, G. P.

10.1101/2025.04.11.648396 — genetics — Posted on 2025-04-11

3163 A structural roadmap for the formation of the coronavirus nsp3/nsp4 double membrane vesicle pore and its implications for polyprotein processing and replication/transcription

Perry, J.; Itskanov, S.; Bilello, J. P.; Lansdon, E.

10.1101/2025.04.10.648184 — molecular biology — Posted on 2025-04-11

3164 On the path to reference genomes for all biodiversity: lessons learned and laboratory protocols created in the Sanger Tree of Life core laboratory over the first 2000 species

Howard, C.; Denton, A.; Jackson, B.; Bates, A.; Jay, J.; Yatsenko, H.; Raman, P. S.; Thomas, A.; Oatley, G.; do Amaral, R. V.; Göktan, Z. E.; Gomez, J. P. N.; Clayton Lucey, I.; Sinclair, E.; Quail, M. A.; Blaxter, M.; Howe, K.; Lawniczak, M.

10.1101/2025.04.11.648334 — molecular biology — Posted on 2025-04-11

3165 Reference Point-Dependent Reinforcement Learning in Humans and Rats

Ferguson, L.; Soukopova, M.; Bouret, S.; Palminteri, S.; Parkes, S.

10.1101/2025.04.11.648377 — molecular biology — Posted on 2025-04-11

3166 De Novo Genome Assembly and Characterization of Plant Growth-Promoting Rhizobacteria isolated from field grown Canola Plants

Blake, C.; deScally, S.; Bhide, A.; Sezmis, A.; Wong, V.; Raman, H.; MCDONALD, M. J.

10.1101/2025.04.11.645141 — microbiology — Posted on 2025-04-11

3167 Unlocking new understanding of Plasmodium sporozoite biology with expansion microscopy

Liffner, B.; Alves e Silva, T. L.; Glennon, E.; Primavera, V. I.; Hoffman, E. A.; Kaushansky, A.; Vega-Rodriguez, J.; Absalon, S.

10.1101/2025.04.09.648058 — microbiology — Posted on 2025-04-11

3168 Overlooked signals: Highly stable quorum sensing molecule in phage lysates induces quorum sensing response

Eichler, A. H.; Mauritzen, J. J.; Koonce, K. C.; Kaur, G.; Hoyland-Kroghsbo, N. M.

10.1101/2025.04.11.648453 — microbiology — Posted on 2025-04-11

3169 Virulence of Fusarium oxysporum strains causing corneal or plant disease is associated with their accessory chromosomes

Ayhan, D. H.; Abbodante, S.; Martinez Soto, D.; Wu, S.; Rodriguez-Vargas, R.; Milo Cochavi, S.; Rickelton, K.; Kotera, S.; Sohrab, V.; Arie, T.; Marshall, M. E.; Rocha, M. C.; Haridas, S.; Grigoriev, I.; Shlezinger, N.; Pearlman, E. S.; Ma, L.-J.

10.1101/2024.05.23.595639 — microbiology — Posted on 2025-04-11

3170 Root Microbial Functions and Robust Network Drive High-yielding Canola Genotype

Li, Y.; Mamet, S. D.; Vail, S.; Siciliano, S. D.

10.1101/2025.04.11.648446 — microbiology — Posted on 2025-04-11

3171 Amplicon sequencing detects, identifies, and quantifies minority variants in mixed-species infections of Cryptosporidium parasites

Turner, R.; Naguib, D.; Pierce, E.; Li, A.; Valente, M.; Glenn, T.; Rosenthal, B. M.; Kissinger, J. C.; Khan, A.

10.1101/2025.04.10.648298 — microbiology — Posted on 2025-04-11

3172 Exploring Population Differences in the Human Gut Microbiome: from Microbial Abundance to Single Nucleotide Polymorphisms

WANG, J.; Zhang, Z.; Chen, Y.; Zhou, X.; Xiang, J.; Yang, C.; Rodionov, D. A.; Osterman, A. L.; Qiu, Q.; Deng, Y.; Liu, Y.; Wang, C.; Shang, X.; Huang, L.; Sun, C.; Guo, J.; Yang, Z.; Han, L.; Zhai, L.; Bian, Z.; Jia, W.; Fang, X.; Zhang, L.

10.1101/2025.04.10.648293 — microbiology — Posted on 2025-04-11

3173 Secreted LysM proteins are required for niche competition and full virulence in Pseudomonas savastanoi during host plant infection

Dominguez-Cervan, H.; Barrientos-Moreno, L.; Diaz-Martinez, L.; Murillo, J.; Perez-Dorado, I.; Ramos, C.; Rodriguez-Moreno, L.

10.1101/2025.04.11.648327 — microbiology — Posted on 2025-04-11

3174 Genetic determinants of gene amplifications alter frequency and evolutionary trajectory of antibiotic resistance in Staphylococcus aureus

Silva, K. P. T.; Khare, A.

10.1101/2025.04.10.647645 — microbiology — Posted on 2025-04-11

3175 Infection dynamics and virulence potential of clinical Pseudomonas aeruginosa isolates in a human airway epithelium model system

Colque, C. A.; Lolle, S.; La Rosa, R.; Pals Bendixen, M.; Simoes, F. B.; Aenaes, K.; Molin, S.; Johansen, H. K.

10.1101/2025.04.11.644308 — microbiology — Posted on 2025-04-11

3176 Altered Duodenal Mucosa-Associated Microbiota and Immune Profiles in Functional Dyspepsia: A Study of Host-Microbiome Homeostasis

Hoedt, E. C.; Burns, G. L.; Kang, S.; Bruce, J.; Morrison, M.; Keely, S.; Talley, N. J.

10.1101/2025.04.10.648308 — microbiology — Posted on 2025-04-11

3177 Phenotypic Approaches to T Cell Activation: A Comparative Mathematical Modeling Study

Bali, Y.; Rendall, A. D.

10.1101/2025.04.07.647688 — immunology — Posted on 2025-04-11

3178 Probing immune signatures of conjugated pattern recognition receptor ligands identifies chimeras with adjuvant and antitumor activity

Janez, S.; Guzelj, S.; Sisic, M.; Frkanec, R.; Pajk, S.; Burgmeijer, L.; Slutter, B.; Jakopin, Z.

10.1101/2025.04.07.647694 — immunology — Posted on 2025-04-11

3179 Prevention of Transgene Silencing During Human PluripotentStem Cell Differentiation

Uenaka, T.; Napole, A. B.; Saha, A. D.; Sun, D.; Singavarapu, A.; Calzada, L.; Chen, J.; Erlebach, L.; McQuade, A.; Ramos, D.; Rigamonti, A.; Salazar, L.; Samelson, A. J.; Sedov, K.; Welsh, N. J.; Wild, K.; Wu, Q.; Arenas, E.; Bassett, A. R.; Kampmann, M.; Kronenberg-Versteeg, D.; Merkle, F. T.; Schule, B.; Thompson, L. M.; Skarnes, W. C.; Ward, M. E.; Wernig, M.

10.1101/2025.04.07.647695 — neuroscience — Posted on 2025-04-11

3180 Conjugated GLP-1 and Estradiol Treatment as a Novel Treatment for Age-related Cognitive Decline in Males and Females

Richard, J.; Mohammed, A.; Go, K.; McGovern, A.; Rechlin, R.; Splinter, T.; Lieblich, S.; Radovic, L.; Feng, L.; Blankers, S.; Yang, B.; Douros, J.; Finan, B.; Galea, L. A.

10.1101/2025.04.07.647672 — neuroscience — Posted on 2025-04-11

3181 Manipulation of the Extracellular Vesicle Biogenesis Pathway in Paternal Somatic Cells Contributes to the Phenotypic Fate of the Next Generation

Salt, E. L.; Scifo, E.; Schaaf, K.; Keshavarz, M.; Liu, T.; Wei, X.; Bano, D.; Ehninger, D.

10.1101/2025.04.07.647377 — physiology — Posted on 2025-04-11

3182 Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer's disease and epilepsy

Li, H.; Xie, Z.; Tian, Y.; Yang, Y.; Lin, B.; Chen, S.; Li, J.; Wu, J.; Chen, M.; Liu, X.; Sun, Y.; Deng, Z.; Hong, M.; Huang, B.; Wei, N.; Ji, X.

10.1101/2024.10.28.618752 — systems biology — Posted on 2025-04-11

3183 Spatial Clustering of Interface Residues Enhances Few-Shot Prediction of Viral Protein Binding

Basse, M.; Wang, D.; Shakhnovich, E.

10.1101/2025.04.10.647895 — molecular biology — Posted on 2025-04-11

3184 Fibro-Adipogenic Progenitors require autocrine IGF-I in homeostatic and regenerating skeletal muscle

Luo, Y. E.; Abe-Teh, Z.; Alsaghir, T.; Kuo, L.-Y.; Yu, F.; Stoker, B. E.; Appu, A. B.; Zhou, Y.; Yue, F.; Kopinke, D.; Barton, E.

10.1101/2025.04.11.648330 — molecular biology — Posted on 2025-04-11

3185 A noncanonical Pol III-dependent, Microprocessor-independent biogenesis pathway generates a germline enriched miRNA family

Sakhawala, R.; Vieux, K.-F.; Haskell, D.; Yu, G.; Zinovyeva, A.; McJunkin, K.

10.1101/2025.04.11.648421 — molecular biology — Posted on 2025-04-11

3186 Light-Controlled Synthetic Communication Networks via Paired Connexon Nanopores

Sihorwala, A. Z.; Lin, A. J.; Ramirez-Velez, I.; Yang, S.; Chowdhury, S.; Stachowiak, J. C.; Belardi, B.

10.1101/2025.04.11.648033 — synthetic biology — Posted on 2025-04-11

3187 Loss of the ESX-5 secretion locus in Mycobacterium tuberculosis reshapes the mycomembrane and enhances ESX-1 substrate secretion

Koleske, B.; Rajagopalan, S.; Schill, C.; Lun, S.; Vilcheze, C.; Das, L.; Gupta, M.; Martinez-Martinez, Y. B.; Jacobs, W. R.; Bishai, W. R.

10.1101/2025.04.11.648440 — microbiology — Posted on 2025-04-11

3188 MHC Class I-like Gene in Squirrel Monkey Cytomegalovirus and the Evolution of the Virus

Hondo, E.; Mizutani, T.; Shimoda, H.; Iida, A.

10.1101/2025.04.10.648282 — microbiology — Posted on 2025-04-11

3189 Age and maturation stage linked consequences of fibrinogen on human oligodendroglia

Blaszczyk, G. J.; Weng, C.; Mohammadnia, A.; Cui, Q. L.; Giurleo, A.; Groh, A. M. R.; Plouffe, C.; Sirois, J.; Piscopo, V. E. C.; Yaqubi, M.; Taqvi, A.; Cassidy, E.; Hall, J. A.; Dudley, R. W. R.; Srour, M.; Zandee, S. E. J.; Klement, W.; Larouche, S.; Prat, A.; Durcan, T. M.; Stratton, J. A.; Antel, J. P.; Moore, G. R. W.

10.1101/2024.05.27.596068 — neuroscience — Posted on 2025-04-11

3190 Analysis of natural structures and chemical mapping data reveals local stability compensation in RNA

Cornwell-Arquitt, R. L.; Nigh, R.; Hathaway, M. T.; Yesselman, J. D.; Hendrix, D. A.

10.1101/2024.12.11.627843 — biophysics — Posted on 2025-04-11

3191 Revealing a coherent cell state landscape across single cell datasets with CONCORD

Zhu, Q.; Jiang, Z.; Thomson, M.; Gartner, Z. J.

10.1101/2025.03.13.643146 — bioinformatics — Posted on 2025-04-11

3192 A map of integrated cis-regulatory elements enhances gene regulatory analysis in maize

Staut, J.; Manosalva Perez, N.; Matres Ferrando, A.; Dissanayake, I.; Vandepoele, K.

10.1101/2024.08.01.606127 — bioinformatics — Posted on 2025-04-11

3193 Economic analysis of disease and control of multi-field epidemics in agriculture

Mikaberidze, A.; Gokhale, C. S.; Bargues-Ribera, M.; Verma, P.

10.1101/2023.09.05.556392 — evolutionary biology — Posted on 2025-04-11

3194 Complex genetic determinism of male-fertility restoration in the gynodioecious snail Physa acuta

Skarlou, E.; Laugier, F.; Bethune, K.; Chenin, T.; Donnay, J.-M.; Froissard, C.; David, P.

10.1101/2024.08.08.607164 — evolutionary biology — Posted on 2025-04-11

3195 Targeting the WSB2-NOXA Axis in Cancer Cells for Enhanced Sensitivity to BCL-2 Family Protein Inhibitors

Jiao, D.; Chang, K.; Chen, Y.; Jin, J.; Ren, M.; Zhang, Y.; Gao, K.; Xu, Y.; Wang, L.; Wang, C.

10.1101/2024.04.24.590941 — cell biology — Posted on 2025-04-11

3196 The mitochondrial NAD transporter SLC25A51 is a modulator of beta cell senescence and type 2 diabetes

Kong, B.; L'Yi, S.; Ramirez-Hernandez, E. G.; Hong, S.; Weidenspointner, R.; Song, S.; Caserta, C.; Cho, Y. M.; Kory, N.

10.1101/2025.04.09.647991 — cell biology — Posted on 2025-04-11

3197 Time-resolved phenotyping at subcellular resolution reveals shared principles and key trade-offs across antimicrobial peptide activities

Fragasso, A.; Schlechtweg, T.; Lin, W.-H.; Barron, A. E.; Jacobs-Wagner, C.

10.1101/2025.04.10.648262 — microbiology — Posted on 2025-04-11

3198 Characterizing Oligodendrocyte-Lineage Cells and Myelination in the Basolateral Amygdala: Insights from a Novel Methodology in Postmortem Human Brain

Perlman, K.; Curto, E.; Barnett-Burns, S.; Davoli, M.-A.; Yerko, V.; Merza, R.; Papadakis, A. I.; Spatz, A.; Pryce, C. R.; Turecki, G.; Mechawar, N.

10.1101/2025.01.09.631560 — neuroscience — Posted on 2025-04-11

3199 Spheroplasted cells: a game changer for DNA delivery to diatoms

Walker, E. J. L.; Pampuch, M.; Deng, L.; Li, Y.; Tran, G.; Mock, T.; Karas, B. J.

10.1101/2024.10.10.617634 — synthetic biology — Posted on 2025-04-11

3200 Cryopreservation of Human Cortical Organoids Using Vitrification.

Mojica-Perez, S.; Stokes, K.; Jacobs, S.; Huang, J.; Vaid, S.; Yuan, y.; Pearson, C. A.; Montes, D.; Tidball, A.; VanHeyningen, D.; Gaillard, J.; Dang, L. T.; Ross, M. E.; Isom, L. L.; Uhler, M.; Niu, W.; Parent, J. M.

10.1101/2025.04.08.647634 — neuroscience — Posted on 2025-04-11

3201 Identifying genes underlying parallel evolution of stromal resistance to placental and cancer invasion

Suhail, Y.; Du, W.; Afzal, J.; Wagner, G.; Kshitiz,

10.1101/2025.04.07.647587 — cancer biology — Posted on 2025-04-11

3202 Ontology-based Protein-Protein Interaction Explanation Using Large Language Models

Cam, N. B.; Rehana, H.; Zheng, J.; Bansal, B.; He, Y.; Hur, J.; Ozgur, A.

10.1101/2025.04.07.647599 — bioinformatics — Posted on 2025-04-11

3203 Bridging macroscopic and microscopic modeling of electric field by brain stimulation

Wang, B.; Aberra, A. S.

10.1101/2025.04.07.647453 — bioengineering — Posted on 2025-04-11

3204 Immunomodulation by AZD1656 reverses cardiac dysfunction, metabolic remodelling and reduces infarct size in type 2 diabetic cardiomyopathy

Anderson, S.; Karlstaedt, A.; Chen, J.; O'Riordan, C.; Barnes, M.; Staka, Z.; Albee, L.; Garrod-Ketchley, C.; Vithanachchi, S.; Prag, H.; Cvetko, F.; Thiemermann, C.; Lewis, A. J.; Murphy, M. P.; Smith, D. M.; Henson, S.; Tyler, D.; Aksentijevic, D.

10.1101/2025.04.10.648128 — physiology — Posted on 2025-04-11

3205 On the ancestry and evolution of the extinct dire wolf

Gedman, G.; Morrill Pirovich, K.; Oppenheimer, J.; Hyseni, C.; Cassatt-Johnstone, M.; Alexandre, N.; Troy, W.; Chao, C.; Fedrigo, O.; Hoyt, S. J.; Grady, P. G. S.; Sacco, S.; Seligmann, W.; Dash, A.; Chokshi, M.; Knecht, L.; Papizan, J. B.; Miyawaki, T.; Bocklandt, S.; Kelher, J.; Ord, S.; Lin, A. T.; Peecook, B.; Perri, A.; Sinding, M.-H. S.; Larson, G.; Meachen, J.; Dalen, L.; vonHoldt, B.; Gilbert, M. T. P.; Mason, C. E.; O'Neill, R. J.; Karlsson, E.; Cantarel, B. L.; Martin, G. R. R.; Church, G.; Lamm, B.; Shapiro, B.

10.1101/2025.04.09.647074 — evolutionary biology — Posted on 2025-04-11

3206 Invasive Aedes vittatus mosquitoes in Jamaica: A looming public health concern

Noble, S. A. A.; Ali, R. L. M. N.; Wilson-Clarke, C. F.; Khouri, N. K.; Norris, D. E.; Sandiford, S. L.

10.1101/2025.04.10.648144 — ecology — Posted on 2025-04-11

3207 Optical activation of midbrain dopamine neurons: do high and low stimulation frequencies produce functionally different effects?

Voisard, J.; Cossette, M.-P.; Arvanitogiannis, A.; Shizgal, P.

10.1101/2025.04.09.643378 — neuroscience — Posted on 2025-04-11

3208 Putting causality into context: Causal capture escapes the visual adaptation of causality

Sommer, B.; Rolfs, M.; Ohl, S.

10.1101/2025.04.10.648104 — neuroscience — Posted on 2025-04-11

3209 Restoration of urban salmon habitat has limited effects on a key ecosystem function

Wik, A. R.; Little, C. J.

10.1101/2025.04.11.648418 — ecology — Posted on 2025-04-11

3210 rsofun v5.0: A model-data integration framework for simulating ecosystem processes

Aran Paredes, J.; Hufkens, K.; Marcadella, M.; Bernhard, F.; Stocker, B. D.

10.1101/2023.11.24.568574 — ecology — Posted on 2025-04-11

3211 Shared computational principles for mouse superior colliculus and primate population orientation selectivity

Kuo, A.; Gardner, J. L.; Merriam, E. P.

10.1101/2025.02.22.639626 — neuroscience — Posted on 2025-04-11

3212 Extra-cellular matrix remodeling as a unique mechanism of expansion of periprostatic adipose tissue: a potential driver of prostate cancer aggressiveness

Esteve, D.; Toulet, A.; Roumiguie, M.; Bu, D.; Lacombe, M.; Pericart, S.; Belles, C.; Manceau, C.; Houel, C.; Ducoux-Petit, M.; Van Acker, N.; Dauvillier, S.; Jia, Y.; Hernandez, M.; Moutahir, M.; Franchet, C.; Doumerc, N.; Thoulouzan, M.; Le Gonidec, S.; Valet, P.; Malavaud, B.; Burlet-Schiltz, O.; Bouloumie, A.; Scherer, P. E.; Milhas, D.; Muller, C.

10.1101/2023.01.05.522843 — cancer biology — Posted on 2025-04-11

3213 Modelling medulloblastoma pathogenesis and treatment in human cerebellar organoids.

Willott, T. O.; Nicholson, J. G.; Xiao, Y.; Ogunbiyi, O. K.; Draper, B.; Mistry, T.; Donovan, L.; Zabet, N. R.; Merve, A.; Badodi, S.; Marino, S.

10.1101/2024.08.14.607977 — cancer biology — Posted on 2025-04-11

3214 The nuclear egress complex of MHV-68 is not essential for nuclear egress but mediates C-capsid specificity

Sanders, S.; Schneider, C.; Soh, T. K.; Kotova, E.; Steer, B.; Reimer, R.; Ruzsics, Z.; Adler, H.; Bosse, J.

10.1101/2025.04.10.648238 — microbiology — Posted on 2025-04-11

3215 Myxobacteria isolated from RAS: Ecology and significance as off-flavor producers

Södergren, J.; Noguera, P. M.; Petersen, M. A.; Jorgensen, N. O. G.; Podduturi, R.; Nicolaisen, M. H.

10.1101/2025.04.10.648225 — microbiology — Posted on 2025-04-11

3216 VH-replacement shapes the antibody repertoire by targeting non-pairing heavy-chains

White, H. N.; Chovanec, P.; Biggins, L.; French, E. C.; Bullen, G.; Andrews, S.; Corcoran, A. E.

10.1101/2025.04.07.647564 — immunology — Posted on 2025-04-11

3217 Candidate NAMPT modulators from traditional African, Chinese, and Russian medicinal plants

Nahalkova, J.

10.1101/2025.04.07.647561 — neuroscience — Posted on 2025-04-11

3218 Incremental Self-Organization of Spatio-Temporal Spike Pattern Detection

Dehghani-Habibabadi, M.; Müller, L.; Pawelzik, K.

10.1101/2023.07.29.551088 — neuroscience — Posted on 2025-04-11

3219 Next-level high-precision spatial omics enabled through spatial similarity networking

Sharma, V. V.; Toth, G.; Martinis, R.; Hansen, C. E.; Kooij, G.; Lanekoff, I.

10.1101/2025.03.07.642022 — neuroscience — Posted on 2025-04-11

3220 Transfer Learning and Permutation-Invariance improving Predicting Genome-wide, Cell-Specific and Directional Interventions Effects of Complex Systems

Wang, B.; Pan, B.; Zhang, T.; Liu, Q.; Li, S.

10.1101/2025.04.07.647536 — systems biology — Posted on 2025-04-11

3221 Genome-wide Identification of the Laccase Gene Family in White Jute (Corchorus capsularis): Potential Targets for Lignin Engineering in Bast Fiber

Parida, S.; Jha, D. K.; Kumari, K.; Pradhan, S.; Dey, N.; Majumder, S.

10.1101/2024.07.17.603856 — plant biology — Posted on 2025-04-11

3222 Molecular architecture of thylakoid membranes within intact spinach chloroplasts

Wietrzynski, W.; Lamm, L.; Wood, W. H. J.; Loukeri, M.-J.; Malone, L.; Peng, T.; Johnson, M. P.; Engel, B. D.

10.1101/2024.11.24.625035 — plant biology — Posted on 2025-04-11

3223 Transmembrane channel-like proteins regulate crop size and contraction dynamics during Drosophila feeding

Nath, D. K.; Dhakal, S.; LEE, Y.

10.1101/2025.04.07.647529 — physiology — Posted on 2025-04-11

3224 Age-Dependent Mechanisms of Cardiac Hypertrophy Regression Following Exercise in Female Mice

Leinwand, L. A.; Crocini, C.

10.1101/2025.04.07.647563 — physiology — Posted on 2025-04-11

3225 Conditional deletion of Tmem63b does not impact mouse voiding behavior

Dalghi, M. G.; Ruiz, W. G.; Clayton, D. R.; Parakala-Jain, T.; Carattino, M. D.; Shi, Y. S.; Apodaca, G.

10.1101/2025.04.07.647591 — physiology — Posted on 2025-04-11

3226 The Role of N-acetylcysteine Amide in Acute Graft-versus-host Disease Mouse Model

He, R.; Zheng, W.; Rozing, K.; Moro, C. F.; Li, X.; Yin, Y.; Zhou, W.; Andaloussi, S. E.; Norgren, S.; Zhao, Y.; Hassan, M.

10.1101/2025.04.07.647501 — pharmacology and toxicology — Posted on 2025-04-11

3227 A novel antioxidant N-acetylcysteine Amide Alleviates Cyclophosphamide-induced Endothelial Damage

He, R.; Zheng, W.; Slof, T.; Wardell, E.; Mansson-Broberg, A.; Norgren, S.; Zhao, Y.; Hassan, M.

10.1101/2025.04.07.647539 — pharmacology and toxicology — Posted on 2025-04-11

3228 Metabolic cell death of labile iron deficiency as a vulnerability of head and neck squamous cancer cells evaded by BACH1

Rokugo, M.; Nakamura, K.; Matsumoto, M.; Endo, A.; Nguyen, L. C.; Nishizawa, H.; Shima, R.; Kashiwagi, H.; Okoshi, A.; Nakanome, A.; Funayama, R.; Nakayama, K.; Ogawa, T.; Abe, T.; Katori, Y.; Igarashi, K.

10.1101/2025.04.07.647470 — cancer biology — Posted on 2025-04-11

3229 FLASH radiotherapy spares lymphocytes in tumor-draining lymph nodes and increases infiltration of immune cells in tumors

Saenz, F. R.; Velasquez, B.; Waldrop, T.; Aguilar, E.; Cox, K. R.; Delahoussaye, A.; Laberiano-Fernandez, C.; Campos Clemente, L.; Connell, L.; Mims, N.; Neill, D.; Parra, E. R.; Clise-Dwyer, K.; Schueler, E.; Spiotto, M. T.

10.1101/2025.04.07.647544 — cancer biology — Posted on 2025-04-11

3230 Structures of protein folding intermediates on the ribosome

Chan, S. H. S.; Streit, J. O.; Wlodarski, T.; Mitropoulou, A.; Cabrita, L. D.; Christodoulou, J.

10.1101/2025.04.07.647236 — biophysics — Posted on 2025-04-11

3231 Mechanical control of tissue growth during limb regeneration

Edwards-Jorquera, S.; Ceccarelli, A.; Schlüssler, R.; Murali Shankar, N.; Munoz Ovalle, A.; Gentleman, K.; Freudenberg, U.; Werner, C.; Chara, O.; Taubenberger, A. V.; Sandoval-Guzman, T.

10.1101/2025.04.07.647008 — biophysics — Posted on 2025-04-11

3232 Assessing simulation-based supervised machine learning for demographic parameter inference from genomic data

Quelin, A.; Austerlitz, F.; Jay, F.

10.1101/2025.04.07.647546 — bioinformatics — Posted on 2025-04-11

3233 scnanoseq: an nf-core pipeline for Oxford Nanopore single-cell RNA-sequencing

Trull, A.; nf-core community, ; Worthey, E. A.; Ianov, L.

10.1101/2025.04.08.647887 — bioinformatics — Posted on 2025-04-11

3234 ASMC: investigating the amino acid diversity of enzyme active sites.

Bailly, T.; Elisee, E.; Vallenet, D.

10.1101/2025.04.07.647545 — bioinformatics — Posted on 2025-04-11

3235 Using Cancer Profiles to Identify Synthetic Lethal Therapeutic Targets and Predictive Biomarkers in Cancer Gene Dependency Data

Pearl, L. H.; Pearl, F.

10.1101/2025.04.07.647559 — bioinformatics — Posted on 2025-04-11

3236 Targeting Ubiquitin-Specific Protease 7 (USP7): A Pharmacophore-Guided Drug Repurposing and Physics-Based Molecular Simulations Study

Kanan, T.; Kanan, D.; Erol, I.; Dogan, B.; Durdagi, S.

10.1101/2025.04.07.647568 — bioinformatics — Posted on 2025-04-11

3237 Effects of Soft Encapsulation on the Receive Performance of PMUTs for Implantable Devices

Velea, A. I.; Panskus, R.; Szabo, B.; Oppelt, V. A.-L.; Holzapfel, L.; Karuthedath, C. B.; Sebastian, A. T.; Stieglitz, T.; Savoia, A. S.; Giagka, V.

10.1101/2025.04.07.646993 — bioengineering — Posted on 2025-04-11

3238 Stress attenuation by the adrenergic-specific lncRNA NESPR prevents cell death in neuroblastoma cells

Delhaye, L.; Rombaut, D.; de Bony, E. J.; D'haene, E.; Brazao, T. F.; Depestel, L.; Decaesteker, B.; Van Haver, S.; Martinez, R.; Dipalo, L. L.; Roels, J.; Verniers, K.; Yigit, N.; Anckaert, J.; Menten, B.; Vergult, S.; Van Vlierberghe, P.; Roberts, S.; Milazzo, G.; Perini, G.; Sanda, T.; Speleman, F.; Eyckerman, S.; Mestdagh, P.

10.1101/2025.04.07.647560 — genetics — Posted on 2025-04-11

3239 Eukaryotes evade information storage-replication rate trade-off with endosymbiont assistance leading to larger genomes

Subramanian, H.; Sahu, P.; Barik, S.; Ghosh, K.

10.1101/2025.04.07.647530 — evolutionary biology — Posted on 2025-04-11

3240 Wuhan sharpbelly bornavirus (genus Cultervirus) can infect a wide range of host cells and establishes persistent infection in diverse cypriniform cells

Eshak, M. I. Y.; Breithaupt, A.; Tews, B. A.; Luttermann, C.; Franzke, K.; Scheibe, M.; Woelke, S.; Rubbenstroth, D.; Beer, M.; Pfaff, F.

10.1101/2025.03.26.645528 — molecular biology — Posted on 2025-04-11

3241 Gut Microbiota Alterations Across REM Sleep Behavior Disorder and Parkinson's Disease: A Machine Learning-Based Meta-Analysis

Arıkan, M.

10.1101/2025.04.09.647562 — microbiology — Posted on 2025-04-11

3242 Searchlight-based trial-wise fMRI decoding in the presence of trial-by-trial correlations

Soch, J.

10.1101/2023.12.05.570090 — neuroscience — Posted on 2025-04-11

3243 Gene Set Analysis for time-to-event outcome with the Generalized Berk-Jones statistic

Ferte, T.; Villain, L.; Thiebaut, R.; Hejblum, B. P.

10.1101/2021.09.07.459329 — bioinformatics — Posted on 2025-04-11

3244 Small Accelerations of the cell generate sufficient nuclear motion to modulate transcriptional activity, driving cellular response independent of matrix strain

Nikitina, N.; Wadsworth, J.; Goelzer, M.; Goldfeldt, M.; Bursa, N.; Howard, S.; Crandall, C.; Semodji, A.; Zavala, A. G.; Judex, S.; Rubin, J.; Lujan, T. J.; Fitzpatrick, C. K.; Rubin, C. T.; Satici, A.; Uzer, G.

10.1101/2025.04.07.647583 — bioengineering — Posted on 2025-04-11

3245 An update to the global Critical Habitat layer

Dunnett, S.; Muge, A.; Ross, A.; Turner, J. A.; Burgess, N. D.; Jones, M. I.; Brooks, S.

10.1101/2025.04.01.646588 — ecology — Posted on 2025-04-11

3246 Age-dependent expression and antiviral activity of interferon epsilon in respiratory epithelium

McCabe, M.; Groves, H. E.; Getty, E.; Campbell, E.; Bamford, C. G. G.; Lopez Campos, G.; Shields, M. D.; Power, U. F.

10.1101/2025.04.08.647778 — microbiology — Posted on 2025-04-11

3247 The cardiac, respiratory, and gastric rhythms independently modulatemotor corticospinal excitability in humans

Engelen, T.; Schuhmann, T.; Sack, A. T.; Tallon-Baudry, C.

10.1101/2024.09.10.612221 — neuroscience — Posted on 2025-04-11

3248 Optimizing automated detection for cytoplasmic TDP25 aggregates in fluorescence imaging

Sogawa, S.; Sasaki, K.; Kitamura, A.

10.1101/2025.04.04.647339 — biophysics — Posted on 2025-04-11

3249 Correlated evolution of the neck, head and forelimb across the theropod-bird transition

Marek, R. D.; Felice, R. N.

10.1101/2025.04.04.647043 — evolutionary biology — Posted on 2025-04-11

3250 Dynamics of recombination, X inactivation and centromere proteins during stick insect spermatogenesis

Dumas, Z.; Toubiana, W.; Delattre, M.; Schwander, T.

10.1101/2024.09.05.611401 — cell biology — Posted on 2025-04-11

3251 Single-vesicle tracking of α-synuclein oligomers reveals pore formation by a three-stage model modulated by charge, curvature, lipids and ligands

Brochner, B. V.; Zhang, X.; Nielsen, J.; Kjems, J.; Otzen, D. E.; Malle, M. G.

10.1101/2025.04.10.648112 — biophysics — Posted on 2025-04-11

3252 Spatial artefact detection improves reproducibility of drug screening experiments

Ianevski, A.; Nader, K.; Potdar, S.; Gorbonos, A.; Ianevski, F.; Tanoli, Z.; Saarela, J.; Aittokallio, T.

10.1101/2025.04.07.647506 — bioinformatics — Posted on 2025-04-11

3253 Plasmodium falciparum quinine resistance is multifactorial and includes a role for the drug/metabolite transporters PfCRT and DMT1

Kanai, M.; Mok, S.; Yeo, T.; Shears, M. J.; Jeon, J. H.; Narwal, S. K.; Ross, L. S.; Haile, M. T.; Tripathi, A. K.; Mlambo, G.; Kim, J.; Gil-Iturbe, E.; Okombo, J.; Park, H.; Wiradiputri, K.; Ward, K. E.; Rozenberg, F. D.; Fairhurst, K. J.; Bloxham, T. S.; Bridgford, J. L.; Sheth, T. R.; Lee, M. C.; Small-Saunders, J. L.; Mancia, F.; Quick, M.; Uhlemann, A.-C.; Sinnis, P.; Fidock, D. A.

10.1101/2024.09.27.615529 — genetics — Posted on 2025-04-11

3254 Bird population trend analyses for a monitoring scheme with a highly structured sampling design

Rieger, M. R.; Grueneberg, C.; Oberhaus, M.; Trautmann, S.; Parepa, M.; Anthes, N.

10.1101/2024.06.30.601382 — ecology — Posted on 2025-04-11

3255 Local nutrient addition drives plant biodiversity losses but not biotic homogenization in global grasslands

Chen, Q.; Blowes, S.; Harpole, S.; Ladouceur, E.; Borer, E.; MacDougall, A.; Bakker, J. D.; Tognetti, P. M.; Seabloom, E. W.; Daleo, P.; Martina, J.; Roscher, C.; Adler, P.; Wheeler, G.; Estrada, C.; Stevens, C.; Veen, C.; Risch, A. C.; Donohue, I.; Hautier, Y.; Wardle, G.; Haider, S.; Hersch-Green, E.; Niu, Y.; Peri, P. L.; Power, S. A.; Eskelinen, A.; Gruner, D.; Olde Venterink, H.; D'Antonio, C.; Cadotte, M.; Eisenhauer, N.; Virtanen, R.; Catford, J.; Morgan, J.; Tedder, M.; Bagchi, S.; Maria, C.; Bugalho, M.; Knops, J.; Dickman, C.; Hagenah, N.; Jentsch, A.; Macek, P.; Osborne, B.; Laanist

10.1101/2024.03.27.586835 — ecology — Posted on 2025-04-11

3256 Histone Variant H3.3 Mediates DNA Repair and cGAS-STING Pathway Activation in Telomere Dysfunction

Huang, C.-M.; Chen, L.-Y.

10.1101/2024.08.07.606966 — molecular biology — Posted on 2025-04-11

3257 Effects of biological and environmental factors on orthoebolavirus serology in bats in Guinea

Champagne, M.; Cappelle, J.; Caron, A.; Pouliquen, T.; Samoura, A.; Doumbouya, M. I.; Thaurignac, G.; Soumah, A. K.; Ayouba, A.; Keita, A. K.; Peeters, M.; Bourgarel, M.; De Nys, H. M.

10.1101/2023.08.23.554395 — microbiology — Posted on 2025-04-11

3258 α7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex

Mukhtar, T.; Siebert, C.-V.; Wang, Y.; Pebworth, M.-P.; White, M. L.; Wu, T.; Huang, T. I.; Zuo, G.; Ross, J.; Baltazar, J.; Upadhyay, V.; Shankar, M.; Zhou, L.; Lombardi-Coronel, I.; Mandala, I.; Adam, M. A.; Wang, S.; Bi, Q.; Hoekman, M. F. M.; Li, J.; Kriegstein, A.

10.1101/2025.04.10.647795 — neuroscience — Posted on 2025-04-11

3259 The Evolving Landscape of Neuroscience

Senden, M.

10.1101/2025.02.13.638094 — neuroscience — Posted on 2025-04-11

3260 MdAGG apple lectins in Fire Blight resistance: CRISPR/Cas9 validation and their potential for intragenesis approaches.

Bodelot, A.; Dousset, N.; Ravon, E.; Heintz, C.; Brisset, M.-N.; Degrave, A.; VERGNE, E.

10.1101/2024.11.08.622591 — plant biology — Posted on 2025-04-11

3261 Simplified and refined murine model of reversible aortic constriction for characterizing cardiac functional recovery

Ghajar-Rahimia, E.; Sicard, P.; Castel, L.; Goergen, C. J.; Moore-Morris, T.

10.1101/2025.04.05.646758 — pathology — Posted on 2025-04-11

3262 Impacts of Structural Properties of Myosin II Filaments on Force Generation

Ding, S.; Chou, P.-E.; Deguchi, S.; Kim, T.

10.1101/2024.11.12.623186 — biophysics — Posted on 2025-04-11

3263 The Role of Pace of Life in Animal Social Networks

Walker, R. S.; White, A.; O'Neill, X.; Fefferman, N. H.; Silk, M. J.

10.1101/2025.04.10.648003 — ecology — Posted on 2025-04-10

3264 DTX4 regulates neural progenitor transitions during cortical development

Pedersen, E.; Zhang, S.; Dong, X.; Vallone, V. F.; Epifanova, E.; Willecke, P. M.; Lajko, D.; Schaub, T.; Ambrozkiewicz, M. C.; Textoris-Taube, K.; Stachelscheid, H.; Rosario, M.

10.1101/2025.04.10.648213 — neuroscience — Posted on 2025-04-10

3265 Knock-out of Tpm4.2/actin filaments alters neuronal signaling, neurite outgrowth and behavioral phenotypes in mice.

Genoud, S.; Porto, R. R.; Stefen, H.; Tomanic, T.; Paric, E.; Sarkar, S.; Yoo, D.; Gao, W.; Hardeman, E. C.; Gunning, P. W.; Karl, T.; Power, J.; Fath, T.

10.1101/2025.04.10.648285 — neuroscience — Posted on 2025-04-10

3266 Glycogen metabolism acts in neurons to support glycolytic plasticity

Singh, M.; Wolfe, A. D.; Vishwanath, A. A.; Tsives, A.; Gonzalez, I. J.; Emerson, S. E.; Goodman, R. H.; Colon-Ramos, D.

10.1101/2025.04.10.648039 — neuroscience — Posted on 2025-04-10

3267 α7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex

Kriegstein, A.; Mukhtar, T.; Siebert, C.-V.; Wang, Y.; Pebworth, M.-P.; White, M. L.; Wu, T.; Huang, T. I.; Zuo, G.; Ross, J.; Baltazar, J.; Upadhyay, V.; Shankar, M.; Zhou, L.; Lombardi-Coronel, I.; Mandala, I.; Adam, M. A.; Wang, S.; Bi, Q.; Hoekman, M. F. M.; Li, J.

10.1101/2025.04.10.647795 — neuroscience — Posted on 2025-04-10

3268 Evolution of Enhancers through Duplication

Singh, D.; Hoyt, T.; Yi, S.

10.1101/2025.04.09.648062 — evolutionary biology — Posted on 2025-04-10

3269 Non-uniform temporal scaling of neurogenesis for species-specific dosing of cortical excitatory subtypes

Yamauchi, Y.; Zhou, X. D.; Tarfder, R.; Rouillard, P.; Bilgic, M.; Deguchi, S.; Nakamura, T.; Kishi, Y.; Emoto, K.; Suzuki, I. K.

10.1101/2025.04.10.648214 — developmental biology — Posted on 2025-04-10

3270 Feedback-Feedforward Dynamics Shape De Novo Motor Learning

Avraham, C.; Mawase, F.

10.1101/2025.04.10.648105 — neuroscience — Posted on 2025-04-10

3271 Brain pericytes derived from human pluripotent stem cells retain vascular and phagocytic functions under hypoxia

Kim, Y.; Zhang, M.; Bosworth, A.; TCW, J.; Nih, L. R.; Kisler, K.; Sagare, A. P.; Rust, R.

10.1101/2025.04.10.648232 — neuroscience — Posted on 2025-04-10

3272 High-throughput histopathology for complex in vitro models

Harter, M. F.; D'Arcangelo, E.; Aubert, J.; Lavickova, B.; Havnar, C.; Stoll, B.; Cubela, I.; Filip, A. M.; Gaspa-Toneu, L.; Scherer, J.; Karagkiozi, E.; Dupre, J.-S.; Lopez-Sandoval, R.; Hsia, R.; Norona, L.; Brancati, G.; Okuda, R.; Camp, G.; Shamir, E.; Garcia-Cordero, J. L.; Pereiro, I.; Gjorevski, N.

10.1101/2025.04.01.646522 — pathology — Posted on 2025-04-10

3273 Sintering 3D-Printed Hydroxyapatite-Wollastonite Lattices Improve Bioactivity and Mechanical Integrity for Bone Composite Scaffolds

Bertone, P. M.; Olevsky, L. M.; Kathir, K. L.; Agnew, S. A.; Scheideler, W. J.; Hixon, K. R.

10.1101/2025.04.06.647463 — bioengineering — Posted on 2025-04-10

3274 A modified methyl transferase cofactor to selectively disable gene expression in E. coli

Irving, O. J.; Stone, S.; Neely, R. K.; Albrecht, T.

10.1101/2025.04.10.648196 — genomics — Posted on 2025-04-10

3275 Development of a Comprehensive Analytical Workflow for eDNA Analysis of Vertebrates, Arthropods, and Mollusks

Omino, M.; Sugawara, I.; Takada, K.; Yoshitake, K.

10.1101/2025.04.09.643821 — genomics — Posted on 2025-04-10

3276 Lung microbiomes variable responses to dust exposure

Maltz, M. R.; Topacio, T.; Lo, D. D.; Freund, L.; Zaza, M.; Botthoff, J. K.; Swenson, M.; Cocker, D.; Biddle, T.; Yisrael, K.; Castillo, D. d.; Drover, R.; Aronson, E. L.

10.1101/2025.04.10.648223 — molecular biology — Posted on 2025-04-10

3277 Cyanobacterial metagenomes reflect the spatiotemporal variations in a coastal brackish lagoon

Ray, M.; Umapathy, G.

10.1101/2025.04.10.648224 — microbiology — Posted on 2025-04-10

3278 The ORF6 accessory protein contributes to SARS-CoV-2 virulence and pathogenicity in the naturally susceptible feline model of infection

Nooruzzaman, M.; Butt, S. L.; Rani, R.; Ye, C.; Martinez-Sobrido, L.; Fang, Y.; Diel, D. G.

10.1101/2025.04.09.647941 — microbiology — Posted on 2025-04-10

3279 Spatial artefact detection improves reproducibility of drug screening experiments

Ianevski, A.; Nader, K.; Potdar, S.; Gorbonos, A.; Ianevski, F.; Tanoli, Z.; Saarela, J.; Aittokallio, T.

10.1101/2025.04.07.647506 — bioinformatics — Posted on 2025-04-10

3280 Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer's disease and epilepsy

Li, H.; Xie, Z.; Tian, Y.; Yang, Y.; Lin, B.; Chen, S.; Li, J.; Wu, J.; Chen, M.; Liu, X.; Sun, Y.; Deng, Z.; Hong, M.; Huang, B.; Wei, N.; Ji, X.

10.1101/2024.10.28.618752 — bioinformatics — Posted on 2025-04-10

3281 Genetic structure of mesophotic and shallow Acropora aculeus on isolated atolls of Eastern Australia

Hernandez-Agreda, A.; Hoey, J. A.; van Hulten, D.; Hernandez, P.; Peplow, L.; Muir, P.; Hoegh-Guldberg, O.; van Oppen, M.; Bongaerts, P.

10.1101/2025.04.08.647879 — genomics — Posted on 2025-04-10

3282 Evidence of distal regulations orchestrated by RNAs initiating at short tandem repeats

Grapotte, M.; Vroland, C.; Garrido-Martin, D.; Vignoli, A.; Calero, L.; Bouvier, Q.; Robin, M.; Yip, C. W.; Carninci, P.; Chatelain, C.; Brehelin, L.; Notredame, C.; Guigo, R.; Lecellier, C. H.

10.1101/2025.04.10.648102 — genomics — Posted on 2025-04-10

3283 Chromosome III aneuploidy enhances ethanol tolerance in industrial Saccharomyces cerevisiae by increasing TUP1 expression

Albillos-Arenal, S.; Alonso del Real, J.; Barrio, E.; Querol, A.

10.1101/2025.04.07.647507 — genetics — Posted on 2025-04-10

3284 Parallel erosion of a testis-specific Na+/K+ ATPase in three mammalian lineages sheds light into the evolution of spermatozoa energetics

Valente, R.; Machado, A.; Pericuesta, E.; Garca-Parraga, D.; Artilheiro, N. A.; Alves, F.; Sousa-Pinto, I.; Pinto, B.; Cordeiro, M.; Ruivo, R.; Gutierrez-Adan, A.; Castro, F.

10.1101/2025.04.07.647512 — evolutionary biology — Posted on 2025-04-10

3285 229E- and NL63-like coronaviruses in phyllostomid bats, Belize

Ansil, B. R.; Lei, G.-S.; Santos, A. J.; Letko, M. C.; Seifert, S. N.; Fenton, B.; Simmons, N. B.; Relich, R. F.; Becker, D. J.

10.1101/2025.04.08.647854 — ecology — Posted on 2025-04-10

3286 Time-resolved phenotyping at subcellular resolution reveals shared principles and key trade-offs across antimicrobial peptide activities

Fragasso, A.; Schlechtweg, T.; Lin, W.-H.; Barron, A. E.; Jacobs-Wagner, C.

10.1101/2025.04.10.648262 — microbiology — Posted on 2025-04-10

3287 Critical Period Plasticity is Associated withResilience to Short Unpredictable Stress

Williams, R.; van den Oord, C.; Lee, E.; Fedde, S.; Oscherwitz, G.; Ribic, A.

10.1101/2025.02.26.640466 — neuroscience — Posted on 2025-04-10

3288 Fusing multisensory signals across channels and time

Anil, S.; Goodman, D. F. M.; Ghosh, M.

10.1101/2024.12.19.629348 — neuroscience — Posted on 2025-04-10

3289 High-content microscopy and machine learning characterize a cell morphology signature of NF1 genotype in Schwann cells

Tomkinson, J.; Mattson, C.; Mattson-Hoss, M.; Sarnoff, H.; Bouley, S. J.; Walker, J. A.; Way, G. P.

10.1101/2024.09.11.612546 — systems biology — Posted on 2025-04-10

3290 Identification of Monotonically Classifying Pairs of Genes for Ordinal Disease Outcomes

Fourquet, O.; Afenteva, D.; Zhang, K.; Hautaniemi, S.; Krejca, M.; Doerr, C.; Schwikowski, B.

10.1101/2025.04.10.643941 — systems biology — Posted on 2025-04-10

3291 Gas Vesicle-Expressing Human Pluripotent Stem Cells Enable Multimodal Ultrasound and Optical Coherence Tomographic Imaging

Howells, A. R.; Kim, J.; Park, S.; Wang, X.; Shi, C.; Lian, X.

10.1101/2025.04.10.648235 — synthetic biology — Posted on 2025-04-10

3292 A method to estimate absolute odorant concentration of olfactory stimuli

CONCHOU, L.; TRELEA, I.-C.; GEVAR, J.; MONSEMPES, C.; PERON, A.-C.; RENOU, M.; SOUCHON, I.; LUCAS, P.

10.1101/2025.04.10.648182 — synthetic biology — Posted on 2025-04-10

3293 De novo chemo-optogenetics through rational small-molecule design and TRAP display

Miyazaki, T.; Fujino, T.; Yoshii, T.; Funane, M.; Murata, N.; Kim, C. N.; Nagatoishi, S.; Tsumoto, K.; Hayashi, G.; Murakami, H.; Tsukiji, S.

10.1101/2025.04.10.648175 — synthetic biology — Posted on 2025-04-10

3294 A Precision Gene Engineered B Cell Medicine Producing Sustained Levels of Active Factor IX for Hemophilia B Therapy

Liu, H.; Morgan, R. A.

10.1101/2025.04.06.647090 — pharmacology and toxicology — Posted on 2025-04-10

3295 Andrographolide prevents necroptosis by suppressing generation of reactive oxygen species

Lu, N.; Li, Q.; Duan, L.-h.; Xu, R.; Li, Y.-p.; Shi, F.-l.; Zhou, Z.-y.; Gan, Y.-q.; Hu, B.; Li, J.-h.; He, X.-h.; Ouyang, D.-y.; Zha, Q.-b.

10.1101/2025.04.07.647496 — pharmacology and toxicology — Posted on 2025-04-10

3296 Endometrial cancer progression driven by PTEN-deficiency requires miR-424(322)~503.

Vidal-Sabanes, M.; Bonifaci, N.; Navaridas, R.; Egea, J.; Encinas, M.; Rodriguez-Barrueco, R.; Silva, J. M.; Matias-Guiu, X.; Llobet-Navas, D.; Dolcet, X.

10.1101/2025.04.07.647575 — cancer biology — Posted on 2025-04-10

3297 SpaceBF: Spatial coexpression analysis using Bayesian Fused approaches in spatial omics datasets

Seal, S.; Neelon, B.

10.1101/2025.03.29.646124 — bioinformatics — Posted on 2025-04-10

3298 Cancer Cell Adaptation to Cycling Hypoxia: Integrating Mathematical Modeling with Experimental Validation of HIF-1 Dynamics

Qiu, X.; Liu, Y.; Agmon, E.; Vera-Licona, P.; Kshitiz, ; Suhail, Y.

10.1101/2025.04.06.647478 — bioinformatics — Posted on 2025-04-10

3299 An mTurquoise2-based glucose biosensor

Botman, D.; Tielman, A.; Goedhart, J.; Teusink, B.

10.1101/2024.11.29.626064 — biochemistry — Posted on 2025-04-10

3300 Minimal Correlation but Complementary Diagnostic Utility for Plasma Cell-free RNA and Proteins

Bliss, A.; Loy, C. J.; Kim, J.; Shimizu, C.; Lenz, J. S.; Belcher, E.; Tremoulet, A. H.; Burns, J. C.; De Vlaminck, I.

10.1101/2025.04.09.647972 — genomics — Posted on 2025-04-10

3301 Extreme mobility creates contrasting patterns of panmixia, isolation-by-distance and hybridization in four flying-fox species (Pteropus)

Scheben, A.; McKeown, A.; Walsh, T.; Westcott, D. A.; Metcalfe, S. S.; Vanderduys, E. P.; Webber, B. L.

10.1101/2025.04.06.647431 — evolutionary biology — Posted on 2025-04-10

3302 Transposable elements facilitate the unintentional domestication of a cheese-associated Penicillium mold

Louw, N. L.; Eagan, J. L.; Larlee, J.; Kehler, M.; Keller, N. P.; Wolfe, B. E.

10.1101/2025.04.10.648237 — microbiology — Posted on 2025-04-10

3303 Long-term evolution of prokaryotic genomes in a chemolithotrophic cave over 5.5 million years of isolation

Saati-Santamaria, Z.; Novakova, A.; Carro, L.; Gonzalez-Candelas, F.; Iranzo, J.; Hillebrand-Voiculescu, A. M.; Morais, D.; Vetrovsky, T.; Baldrian, P.; Kolarik, M.; Garcia-Fraile, P.

10.1101/2025.04.10.648229 — microbiology — Posted on 2025-04-10

3304 Structural Basis of Lipopolysaccharide Assembly by the Outer Membrane Translocon Holo-Complex

Chen, H.; Siroy, A.; Morales, V.; Gurvic, D.; Quentin, Y.; Balor, S.; Abuta'a, Y. A.; Marteau, M.; Froment, C.; Caumont-Sarcos, A.; Marcoux, J.; Stansfeld, P. J.; Fronzes, R.; Ieva, R.

10.1101/2025.04.10.648201 — microbiology — Posted on 2025-04-10

3305 A zebrafish immunodeficiency model induced by the combination of Tacrolimus and Everolimus for rapid assessment of immune-enhancing agents

Huang, M.; Jia, Z.; Liu, Y.; Lu, X.; He, X.

10.1101/2025.04.06.647472 — immunology — Posted on 2025-04-10

3306 An in vivo CRISPR screen unveils top target genes to improve CAR-T cell efficacy in a solid tumor model

Fumagalli, M.; An, D.; Simula, L.; Combe, C.; Aziez, L.; Simoni, Y.; Alves-Guerra, M.-C.; Valentini, A.; Marchais, M.; Vermare, A.; Moraly, J.; Bercovici, N.; Donnadieu, E.; Pendino, F.

10.1101/2025.03.28.645780 — immunology — Posted on 2025-04-10

3307 Rational design of selective bispecific EPO-R/CD131 agonists

Doiron, K. E.; Way, J. C.; Silver, P. A.

10.1101/2025.04.10.648227 — synthetic biology — Posted on 2025-04-10

3308 Advancing genetic engineering in the plant growth-promoting agricultural bacterium Azospirillum brasilense.

Riley, E.; Poma, M.; Kelly, C. L.

10.1101/2025.04.08.647883 — synthetic biology — Posted on 2025-04-10

3309 Rapamycin Reduces Arterial Mineral Density and Promotes Beneficial Vascular Remodeling in a Murine Model of Severe Medial Arterial Calcification

Behzadi, P.; Wendling, A. A.; Cuevas, R. A.; Crane, A.; Chu, C. C.; Moorhead, W. J.; Wong, R.; Brown, M.; Tamakloe, J.; Suresh, S.; Saleh, P.; Jaffe, I. A.; Kuipers, A. L.; Lukashova, L.; Verdelis, K.; St. Hilaire, C.

10.1101/2024.08.01.606196 — physiology — Posted on 2025-04-10

3310 Protrusion force and cell-cell adhesion-induced polarity alignment govern collective migration modes

Wang, H.; Ardila, C.; Jindal, A.; Aggarwal, V.; Wang, W.; Vande Geest, J.; Jiang, Y.; Xing, J.; Sant, S.

10.1101/2024.09.18.613706 — cancer biology — Posted on 2025-04-10

3311 Missense variant analysis in the TRPV1 ARD reveals the unexpected functional significance of a methionine

Wulffraat, G. C.; Mamathasateesh, S.; Hudson, R.; He, B.; Jara-Oseguera, A.; Senning, E. N.

10.1101/2025.02.14.638348 — biophysics — Posted on 2025-04-10

3312 Nanoscale curvature of the plasma membrane regulates mechanoadaptation through nuclear deformation and rupture

Francis, E. A.; Sarikhani, E.; Patel, V.; Meganathan, D. P.; Sadr, L.; Jahed, Z.; Rangamani, P.

10.1101/2024.10.18.619165 — biophysics — Posted on 2025-04-10

3313 Discernibility in explanations: an approach to designing more acceptable and meaningful machine learning models for medicine

Wang, H.; Aligon, J.; May, J.; Doumard, E.; Labroche, N.; Delpierre, C.; Soule-Dupuy, C.; Casteilla, L.; Planat, V.; Monsarrat, P.

10.1101/2025.04.06.647498 — bioinformatics — Posted on 2025-04-10

3314 Structural and antigenic characterization of novel and diverse Henipavirus glycoproteins

May, A. J.; Lella, M.; Lindenberger, J.; Berkman, A.; Kumar, U.; Dutta, M.; Barr, M.; Parks, R.; Lu, X.; Berry, M.; Newman, A.; Huang, X.; Song, K.; Ilevbare, V.; Sammour, S.; Park, C. S.; Adhikari, R. D.; Devkota, P.; Janowska, K.; Liu, Y.; Scapellato, G.; Spence, T. N.; Mansouri, K.; Wiehe, K.; Edwards, R. J.; Saunders, K. O.; Haynes, B. F.; Acharya, P.

10.1101/2024.12.11.627382 — biochemistry — Posted on 2025-04-10

3315 Energetic and structural control of polyspecificity in a multidrug transporter

Miller, S. T.; Henzler-Wildman, K. A.; Raman, S.

10.1101/2025.04.09.647630 — biochemistry — Posted on 2025-04-10

3316 Structural evolution of nitrogenase enzymes over geologic time

Cuevas, B.; Detemple, F.; Amritkar, K.; Garcia, A. K.; Seefeldt, L.; Einsle, O.; Kacar, B.

10.1101/2024.11.18.623660 — evolutionary biology — Posted on 2025-04-10

3317 Insulin-dependent and -independent dynamics of insulin receptor trafficking in muscle cells

Cen, H. H.; Mattison, A. J.; Omidi, A.; Rogalski, J.; Abraham, L.; Gao, G.; Gold, M. R.; Foster, L.; Gsponer, J.; Johnson, J. D.

10.1101/2021.06.29.450241 — cell biology — Posted on 2025-04-10

3318 STAR/STARD1: a mitochondrial intermembrane space cholesterol shuttle degraded through mitophagy

Koganti, P. P.; Zhao, A. H.; Kern, M. C.; Fassinou, A. C. R.; Selvaraj, V.

10.1101/2025.04.03.647084 — cell biology — Posted on 2025-04-10

3319 Diffusion-based size determination of solute particles: a method adapted for postsynaptic proteins

Szabo, A. L.; Nagy-Kanta, E.; Varga, S.; Jager, E. A.; Pongor, C. I.; Laki, M.; Laki, A. J.; Gaspari, Z.

10.1101/2025.02.05.636588 — molecular biology — Posted on 2025-04-10

3320 Effect of Azithromycin treatment on the microbial composition, functional dynamics and resistomes of endocervical, vaginal and rectal microbiomes of women in Fiji with Chlamydia trachomatis infection

Bommana, S.; Olagoke, S.; Hu, Y.; Wang, R.; Kama, M.; Dehdashti, M.; Kodimerla, R.; Read, T.; Dean, D.

10.1101/2025.04.02.646699 — microbiology — Posted on 2025-04-10

3321 Using network component analysis to study axenisation strategies for phototrophic eukaryotic microalgae

Iyer, A.; Monissen, M.; Teo, Q.; Modin, O.; Halim, R.

10.1101/2025.03.07.641979 — microbiology — Posted on 2025-04-10

3322 Autonomic Neuropathy is Associated with an Increase in Type-1 Cytokines in People Living with HIV

Mueller, B. R.; Mehta, M.; Campbell, M.; Neupane, N.; Cedillo, G.; Lee, G.; Coyle, K.; Qi, J.; Chen, Z.; George, M. C.; Robinson-Papp, J.

10.1101/2024.10.15.618447 — immunology — Posted on 2025-04-10

3323 Conscious and unconscious perception of pitch shifts in auditory feedback during vocalization: Behavioral functions and event-related potential correlates

Suchy, D.; Behroozmand, R.; Railo, H.

10.1101/2023.10.13.562262 — neuroscience — Posted on 2025-04-10

3324 A reaction norm for flowering time plasticity reveals physiological footprints of maize adaptation

Drouault, J.; Palaffre, C.; Millet, E. J.; Rodriguez, J.; Martre, P.; Johnson, K.; Parent, B.; Welcker, C.; Wisser, R. J.

10.1101/2024.07.10.602692 — plant biology — Posted on 2025-04-10

3325 Environment-Dependent Modes of Adaptive Evolution in Neuroblastoma: Plasticity as a Selectable Trait

Roux, C.; Hamer, S.; Shea, A.; Chen, E.; Sadr, A. S.; English, C.; Allo Anido, A.; Che, H.; Geoerger, B.; Chesler, L.; Schleiermacher, G.; Morgan, M. D.; Bruna, A.

10.1101/2023.12.07.570359 — cancer biology — Posted on 2025-04-10

3326 IL-1β/IRAK4 Axis Promotes Ovarian Tumor Development at the Mesothelium Injury Sites

Miller, J. P.; Kim, K.; Khazan, N.; Snyder, C. W.; Singh, N. A.; Lamere, E.; Strawderman, M.; Sharma, S.; Lakony, R.; Whittum, M.; Anderson, M.; Keenan, R.; Pritchett, E.; Baker, C.; Ashton, J.; Khera, M. K.; Chu, C. C.; Bajaj, J.; Elliott, M. R.; Rowswell-Turner, R.; Calvi, L. M.; Becker, M. W.; Moore, R. G.; Singh, R. K.

10.1101/2025.03.18.643950 — cancer biology — Posted on 2025-04-10

3327 Quantum mechanics predicts Bicoid interpretation time of less than a second

Lone, I.

10.1101/2024.09.10.612267 — biophysics — Posted on 2025-04-10

3328 Atom level enzyme active site scaffolding using RFdiffusion2

Ahern, W.; Yim, J.; Tischer, D.; Salike, S.; Woodbury, S.; Kim, D.; Kalvet, I.; Kipnis, Y.; Coventry, B.; Altae-Tran, H.; Bauer, M.; Barzilay, R.; Jaakkola, T.; Krishna, R.; Baker, D. A.

10.1101/2025.04.09.648075 — biochemistry — Posted on 2025-04-10

3329 Impacts of taxonomic change on the Amazonian palm flora

Stropp, J.; Pereira, A. S. S.; Emilio, T.; Meyer, L.; Trad, R.; Alves-Martins, F.; Ladle, R. J.; Hortal, J.

10.1101/2024.11.29.625979 — ecology — Posted on 2025-04-10

3330 Holoprosencephaly and Cyclopia in bmp7b and bmpr1ba Crispant zebrafish

Kyrychenko, V.; Rensinghoff, P.; Bulk, J.; Frey, C.; Heermann, S.

10.1101/2024.08.09.607306 — developmental biology — Posted on 2025-04-10

3331 An updated catalogue of split-GAL4 driver lines for descending neurons in Drosophila melanogaster

Zung, J. L.; Namiki, S.; Meissner, G. W.; Costa, M.; Eichler, K.; Stürner, T.; Jefferis, G. S. X. E.; Managan, C.; FlyLight Project Team, ; Korff, W.; Card, G. M.

10.1101/2025.02.22.639679 — neuroscience — Posted on 2025-04-10

3332 The interaction of growth with mechanical constraints drives puzzle cell formation in plants

Trozzi, N.; Lane, B.; Perruchoud, A.; Clark, F.; Hoermayer, L.; Meraviglia, A.; Reichgelt, T.; Roeder, A. H. K.; Kwiatkowska, D.; Runions, A.; Smith, R. S.; Majda, M.

10.1101/2023.10.01.560343 — plant biology — Posted on 2025-04-10

3333 Integration of the hammerhead ribozyme into structured RNAs to measure ligand-binding events for riboswitch candidates and aptamers

Zhang, S.; Lin, Y.; Gao, T.; Chen, B.; Wu, W.; Fang, S.; Fan, K.; Lai, Y.; Lin, Y.; Ke, R.; Li, S.

10.1101/2025.04.10.648167 — molecular biology — Posted on 2025-04-10

3334 Genetic and phenotypic diversity of wine-associated Hanseniaspora species

Onetto, C. A.; Ward, C. M.; Varela, C.; Hale, L.; Schmidt, S.; Borneman, A. R.

10.1101/2025.04.09.648064 — microbiology — Posted on 2025-04-10

3335 The alterations of the synthetic pathway and metabolic flux of auxin indole-3-acetic acid (IAA) govern thermotolerance in Lentinula edodes mycelia subjected to heat stress

Wei, X.; Song, J.; Chen, J.; Zhou, Y.; Xiao, Y.; Bian, Y.; Gong, Y.

10.1101/2025.04.09.648085 — microbiology — Posted on 2025-04-10

3336 The joint action of antibiotics, bacteriophage, and the innate immune response in the treatment of bacterial infections

Berryhill, B. A.; Gil-Gil, T.; Levin, B. R.

10.1101/2025.04.10.648192 — microbiology — Posted on 2025-04-10

3337 Regulation of the innate immune response in human neurons by ICP34.5 maintains herpes simplex virus 1 latency

Canova, P. N.; Katzenell, S.; Ceron, S.; Charron, A. J.; Pesola, J. M.; Oh, H. S.; Coen, D. M.; Knipe, D. M.; Leib, D. A.

10.1101/2025.04.04.647253 — immunology — Posted on 2025-04-10

3338 Targeting RET in Brain Metastases from Estrogen Receptor Positive Breast Cancer

Liu, S.; Pecar, G.; Cao, Y.; Chen, F.; Wedn, A.; Atkinson, J. M.; Hooda, J.; Oesterreich, S.; Lee, A. V.

10.1101/2025.04.04.647085 — cancer biology — Posted on 2025-04-10

3339 Histone H3 tail charge patterns govern nucleosome condensate formation and dynamics

Hammonds, E. F.; Singh, A.; Suresh, K. K.; Yang, S.; Meidl Zahorodny, S. S.; Gupta, R.; Potoyan, D. A.; Banerjee, P. R.; Morrison, E. A.

10.1101/2025.04.09.647968 — biophysics — Posted on 2025-04-10

3340 Fixation and extinction in time-fluctuating spatially structured metapopulations

Asker, M.; Swailem, M.; Tauber, U. C.; Mobilia, M.

10.1101/2025.04.10.648186 — biophysics — Posted on 2025-04-10

3341 Metal ion binding of vimentin tail domain fragments

Carranza, E. J.; Heffern, M. C.; Murray, D. T.

10.1101/2025.04.10.648257 — biophysics — Posted on 2025-04-10

3342 Selectivity profiles and substrate recognition of Rab phosphorylating kinases

Chatterjee, D.; Dederer, V.; Nguyen, L. V.; Wendel, M.; Abdul Azeez, K. R.; Mahesula, S.; Stengel, F.; Reck-Peterson, S.; Mathea, S.

10.1101/2025.04.09.647999 — biochemistry — Posted on 2025-04-10

3343 A Morpho-Proteomic Atlas of Mitosis at Sub-Minute Resolution

Migh, E.; Miczan, V.; Post, F.; Koos, K.; Beleon, A.; Kokai, D.; Ivan, Z. Z.; Grexa, I.; Moshkov, N.; Hollandi, R.; Csikos, D.; Hapek, N.; Kaptas, F.; Kovacs, F.; Kriston, A.; Mahdessian, D.; Axelsson, U.; Pal, C.; Lundberg, E.; Manczinger, M.; Mund, A.; Mann, M.; Horvath, P.

10.1101/2025.04.09.647158 — cell biology — Posted on 2025-04-10

3344 An intrinsically disordered region of Drosha selectively promotes miRNA biogenesis, independent of tissue-specific Microprocessor condensates

Yang, B.; Galletta, B.; Rusan, N.; McJunkin, K.

10.1101/2025.04.10.648254 — molecular biology — Posted on 2025-04-10

3345 Establishment of a transgenic strain for the whole brain calcium imaging in larval medaka fish (Oryzias latipes)

Seki, T.; Shiraishi, A.; Miyanari, K.; Tsuda, S.; Ansai, S.; Takeuchi, H.

10.1101/2025.04.09.647916 — molecular biology — Posted on 2025-04-10

3346 Membrane vesicles in freshwater ecosystems: Quantification by flow cytometry and interferometric microscopy

RAVET, V.; ROYET, V.; FEDALA, Y.; Hennequin, C.; DEBROAS, D.; Boccara, M.

10.1101/2025.04.10.647775 — microbiology — Posted on 2025-04-10

3347 High-risk clonal groups of Avian Pathogenic Escherichia coli (APEC) demonstrate heterogeneous phenotypic characteristics in vitro and in vivo

Adams, J. R. G.; Long, H.; Birdsall, C.; Qureshi, K.; King, E.; Perez, S.; Warner, K.; Behboudi, S.; La Ragione, R. M.; Mehat, J. W.

10.1101/2025.04.10.648166 — microbiology — Posted on 2025-04-10

3348 High-throughput LacZ/CPRG screen identifies novel potential antibiotics targeting Gram-negative bacterial envelopes to combat resistance

Ghobakhlou, F.; Mokhtari, L.; Pfeifer, T. A.; Paradis-Bleau, C.

10.1101/2025.04.09.648071 — microbiology — Posted on 2025-04-10

3349 Gene regulatory network determinants of rapid recall in human memory CD4+ T cells

Katko, A.; Korinfskaya, S.; Bejjani, A. T.; Owoeye, S. M.; Yang, Z. F.; Rudrapatna, A.; Wayman, J. A.; Kotliar, M.; Kottyan, L. C.; Barski, A.; Miraldi, E. R.

10.1101/2025.04.06.646912 — systems biology — Posted on 2025-04-10

3350 Cotranslational Protein Folding Through Non-Native Structural Intermediates

Wang, S.; Bitran, A.; Samatova, E.; Shakhnovich, E.; Rodnina, M.

10.1101/2025.04.09.648002 — biophysics — Posted on 2025-04-10

3351 Single-vesicle tracking of α-synuclein oligomers reveals pore formation by a three-stage model modulated by charge, curvature, lipids and ligands

Malle, M. G.; Otzen, D. E.; Brochner, B. V.; Zhang, X.; Nielsen, J.; Kjems, J.

10.1101/2025.04.10.648112 — biophysics — Posted on 2025-04-10

3352 Molecular architecture of heterochromatin at the nuclear periphery of primary human cells

Kreysing, J. P.; Cruz-Leon, S.; Betz, J.; Penzo, C.; Majtner, T.; Schreiber, M.; Turonova, B.; Lusic, M.; Hummer, G.; Beck, M.

10.1101/2025.04.09.647790 — biophysics — Posted on 2025-04-10

3353 Structural and Functional Studies of Rabbit SAMD9 Reveal a Distinct tRNase Module That Underlies the Antiviral Activity

Chaturvedi, J.; Zhang, F.; Zhang, C.; Badhe, S.; Xiang, Y.; Deng, J.

10.1101/2025.04.10.648150 — biochemistry — Posted on 2025-04-10

3354 A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

Chagas, R. S.; Marana, S. R.

10.1101/2025.04.10.648185 — biochemistry — Posted on 2025-04-10

3355 Quantification of Wnt3a, Wnt5a and Wnt16 Binding to Multiple Frizzleds Under Physiological Conditions using NanoBit/BRET

Wesslowski, J.; Safi, S.; Rottmann, M.; Rothley, M.; Davidson, G.

10.1101/2025.04.10.648195 — biochemistry — Posted on 2025-04-10

3356 Acyl-CoA Binding Protein is Dispensable for White and Brown Adipose Tissue Function

Noerremark, M. F.; Petersen, R.; Ruppert, P. M. M.; Doktor, T. K.; Nielsen, R.; Kappel, J. F.; Larsen, S.; Kornfeld, J.-W.; Mandrup, S.; Andresen, B. S.; Havelund, J. F.; Neess, D.; Faergeman, N. J.

10.1101/2025.04.10.642978 — biochemistry — Posted on 2025-04-10

3357 distQTL: Distribution Quantitative Trait Loci Identification by Population-Scale Single-Cell Data

Coulter, A.; Tong, C. Y.; Ni, Y.; Jiang, Y.

10.1101/2025.04.04.647121 — genomics — Posted on 2025-04-10

3358 Translation control of autophagy genes upon hydroxyurea-induced genotoxic stress

Mohanan, G.; Nag, K.; Senger, H. S.; Rajyaguru, P. I.

10.1101/2025.04.09.648074 — cell biology — Posted on 2025-04-10

3359 The mitochondrial NAD transporter SLC25A51 is a modulator of beta cell senescence and type 2 diabetes

Kong, B.; Kory, N.; L'Yi, S.; Ramirez-Hernandez, E. G.; Hong, S.; Weidenspointner, R.; Song, S.; Caserta, C.; Cho, Y. M.

10.1101/2025.04.09.647991 — cell biology — Posted on 2025-04-10

3360 4D mitochondrial network assumes distinct and predictive phenotypes through human lung and intestinal epithelial development

McMahon, G.; Agarwal, D.; Arora, M.; Wang, Z.; Hakozaki, H.; Schöneberg, J.

10.1101/2025.04.09.648043 — cell biology — Posted on 2025-04-10

3361 Histone 3 lysine 36 trimethylation by SETD2 shapes an epigenetic landscape in intestinal stem cells to orchestrate lipid metabolism and prevent cell senescence.

Xu, Y.; Wang, Z.; Feng, W.; Rao, H.; Wang, D.; Zhang, W.; Aji, R.; Liu, N.; Gao, W.-Q.; Li, L.

10.1101/2025.04.09.648070 — cell biology — Posted on 2025-04-10

3362 Nucleophagy is promoted by two autophagy receptors and inhibited by chromatin-nuclear envelope tethering in fission yeast

Ma, Z.-H.; Pan, Z.-Q.; Jiang, Z.-D.; Shao, G.-C.; Hua, Y.; Suo, F.; Zou, C.-X.; Jiang, Y.-F.; Dong, M.-Q.; Du, L.-L.

10.1101/2025.04.09.648038 — cell biology — Posted on 2025-04-10

3363 Phosphodiesterase 3A modulators sensitize tumor cells to Bcl-xL and Bcl-2/Bcl-xL inhibitors

Toivanen, K.; Murumagi, A.; Wozniak, A.; Wyns, K.; Wang, C.-C.; De Sutter, L.; Arjama, M.; Merikoski, N.; Salmikangas, S.; Youssef, O.; Isola, J.; Kallioniemi, O.; Schoffski, P.; Bohling, T.; Sihto, H.

10.1101/2025.04.10.648087 — molecular biology — Posted on 2025-04-10

3364 Unveiling the pathogenicity of Cunninghamella echinulata SMH-1 and its bioactive metabolites through metabolomics: Dual-action disruption of Solenopsis invicta mitochondrial bioenergetics and cuticular integrity

Hussain, M.; Gao, X.; Wu, G.; Qin, D.

10.1101/2025.04.10.648148 — microbiology — Posted on 2025-04-10

3365 Two Spore Types in a Marine Parasite of Dinoflagellates

Szymczak, J.; Pinaud, S.; Romero Rodriguez, I.; Walde, M.; Kayal, E.; Alves-de-Souza, C.; Bigeard, E.; Gallet, B.; Gachenot, M.; Le Panse, S.; Jauzein, C.; Le Gac, M.; Decelle, J.; Pohnert, G.; Vallet, M.; Talman, A. M.; Guillou, L.

10.1101/2025.04.10.648098 — microbiology — Posted on 2025-04-10

3366 Regulation of airway fumarate by host and pathogen promotes S. aureus pneumonia

Chen, Y.-T.; Liu, Z.; Fucich, D.; Giulieri, S. G.; Liu, Z.; Wadhwa, R.; Rios, G.; Henschel, H.; Tyagi, N.; Olivier, F. A. B.; Monk, I. R.; Shah, S. S.; Sridhar, S. H.; Drikic, M.; Bianco, C.; Lohia, G. K.; Beg, A. Z.; Planet, P. J.; Lewis, I. A.; Sebra, R.; Traven, A.; Hachani, A.; Stinear, T. P.; Howden, B.; Boyd, J.; Riquelme, S. A.; Wang, C.; Prince, A. S.; Wong, T.

10.1101/2025.04.10.647998 — microbiology — Posted on 2025-04-10

3367 Establishment, maintenance and consequences of inter-individual transcriptional variability for a gene involved in nitrate nutrition in plants

Lecuyer, C.; Vettor, A.; Fizames, C.; Javot, H.; Martin, A.; Mazouzi, M.; Cortijo, S.

10.1101/2025.04.10.648086 — plant biology — Posted on 2025-04-10

3368 ROS regulation of stigma papillae growth and maturation in Arabidopsis thaliana

Sankaranarayanan, S.; Venkatesan, S. D.; Davis, T. C.; Kessler, S. A.

10.1101/2025.04.08.647846 — plant biology — Posted on 2025-04-10

3369 Pathogenicity and genome assembly of a Pythium aphanidermatum isolate causing damping-off in amaranth in controlled environment agriculture

Thanyasiriwat, T.; Kawicha, P.; MacDonald, S.; Sangdee, A.; Tongyoo, P.; Denby, K.

10.1101/2025.04.10.648180 — plant biology — Posted on 2025-04-10

3370 TIR immune signaling is blocked by phosphorylation to maintain plant growth

Li, J.; Chen, S.; Yu, B.; Li, Q.; Liu, R.; Wang, Z.; Wan, L.; Zhao, Y.

10.1101/2025.04.09.647920 — plant biology — Posted on 2025-04-10

3371 Functional MRI Signatures of Autonomic Physiology in Aging

Fan, J.; Juttukonda, M. R.; Goodale, S. E.; Wang, S.; Orban, C.; Varadarajan, D.; Polimeni, J. R.; Chang, C.; Salat, D. H.; Chen, J. E.

10.1101/2025.04.05.647057 — physiology — Posted on 2025-04-10

3372 Active and Probe-Free Intracellular Rheology via Phase-Sensitive Thermoviscous Flows

Stoev, I. D.; Bolger-Munro, M.; Minopoli, A.; Wagner, S.; Krishnaswamy, V. R.; Erben, E.; Weissenbruch, K.; Maghelli, N.; Bastmeyer, M.; Heisenberg, C.-P.; Kreysing, M.

10.1101/2025.04.07.647540 — biophysics — Posted on 2025-04-10

3373 SpeedyTrack: Direct microsecond wide-field single-molecule tracking and super-resolution mapping via CCD vertical shift

Steves, M. A.; Xu, K.

10.1101/2025.04.07.647376 — biophysics — Posted on 2025-04-10

3374 Temperature and Excipient Mediated Modulation of Monoclonal Antibody Interactions Revealed by kD, Rheology, and Raman Spectroscopy

Eskens, O. N.; Virk, S. S.; Virk, A. S.; Venkataramani, D.; Crames, M.; Vaca, M. C.; Matusewicz, M.; Smith, C.; George, J.; Taylor, C.; Marlow, M. S.; Amin, S.

10.1101/2025.04.06.646989 — biophysics — Posted on 2025-04-10

3375 Atomic Conformational Dynamics and Actin-Crosslinking Function of Alpha-Actinin Revealed by SimHS-AFMfit

Ngo, K. X.; Sumikama, T.; Vuillemot, R.; Nguyen, H. G.; Uyeda, T.; Le, N. T. P.; Grudinin, S.

10.1101/2025.04.06.647477 — biophysics — Posted on 2025-04-10

3376 Molecular Insights into Cholesterol Concentration Effects on Planar and Curved Lipid Bilayers for Liposomal Drug Delivery

Khodadadi, E.; Khodadadi, E.; Chaturvedi, P.; Moradi, M.

10.1101/2025.04.06.647491 — biophysics — Posted on 2025-04-10

3377 Adhesion and injury cues enhance blackworm captureby freshwater planaria

Tiwari, I.; Chudasama, H.; Tuazon, H.; Bhamla, S.

10.1101/2025.04.09.647989 — biophysics — Posted on 2025-04-10

3378 Effect of very long-chain lipids on the organization of biological membranes: A simulation perspective

Quas, A.; Rickhoff, C.; Wedlich-Soldner, R.; Heuer, A.

10.1101/2025.04.08.647797 — biophysics — Posted on 2025-04-10

3379 Sperm meet the elevated energy demands to attain fertilization competence by increasing flux through aldolase

Violante, S.; Kyaw, A.; Kouatli, L.; Paladugu, K.; Apostolakis, L.; Jenks, M.; Johnson, A.; Sheldon, R.; Schilmiller, A.; Visconti, P.; Cross, J.; Levin, L.; Buck, J.; Balbach, M.

10.1101/2025.04.09.647926 — biochemistry — Posted on 2025-04-10

3380 Gut sulfide metabolism modulates behavior and brain bioenergetics

Kumar, R.; Sykes, D. J.; Band, V. I.; Schaller, M. L.; Patel, R.; Vitvitsky, V.; Sajjakulnukit, P.; Singhal, R.; Wong, H. K. A.; Hourigan, S. K.; Ichinose, F.; Lyssiotis, C. A.; Shah, Y. M.; Banerjee, R.

10.1101/2025.04.09.647962 — biochemistry — Posted on 2025-04-10

3381 Energetic and structural control of polyspecificity in a multidrug transporter

Miller, S. T.; Henzler-Wildman, K. A.; Raman, S.

10.1101/2025.04.09.647630 — biochemistry — Posted on 2025-04-10

3382 Atom level enzyme active site scaffolding using RFdiffusion2

Ahern, W.; Yim, J.; Tischer, D.; Salike, S.; Woodbury, S.; Kim, D.; Kalvet, I.; Kipnis, Y.; Coventry, B.; Altae-Tran, H.; Bauer, M.; Barzilay, R.; Jaakkola, T.; Krishna, R.; Baker, D. A.

10.1101/2025.04.09.648075 — biochemistry — Posted on 2025-04-10

3383 Ab-trapping - a peripheral staining artifact in antibody-based microscopy and genomics

Chudzik, K.; Sato, Y.; Yan, X.; Ullrich, S.; Trakarnphornsombat, W.; Schermelleh, L.; Fudenberg, G.; Kimura, H.; Robson, M. I.; Solovei, I.

10.1101/2025.04.09.648027 — cell biology — Posted on 2025-04-10

3384 Protein diffusion controls how single cells respond to electric fields

Nwogbaga, I.; Belliveau, N. M.; Singh, A. R.; Sun, D.; Mulenga, N.; Theriot, J. A.; Camley, B. A.

10.1101/2025.04.09.647627 — cell biology — Posted on 2025-04-10

3385 Tunable 3D Alveolosphere Model from Human Alveolar Cells: A Breakthrough Tool to Explore Emphysema Pathophysiology

Guecamburu, M.; Pavot, A.; Jeanniere, c.; belaroussi, y.; Thumerel, M.; sammaniego, e.; begueret, H.; maucort, g.; decoeur, f.; Dupuy, J.-W.; raymond, a.-a.; esteves, P.; Grassion, L.; dournes, G.; berger, p.; maurat, e.; latouille, e.; Studer, V.; Dupin, I.; henrot, P.; zysman, m.

10.1101/2025.04.09.645486 — cell biology — Posted on 2025-04-10

3386 Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data

Arkfeld, E.; Wang, Z.; Hakozaki, H.; Schoeneberg, J.

10.1101/2025.04.09.647865 — cell biology — Posted on 2025-04-10

3387 Identification of novel candidate regulators of human naive pluripotency by means of a genetic switch utilizing the chimeric receptor G-CSFR:GP130

Kiani, T.; Santamaria, C.; Kafousi, A.; Doerflinger, N.; Rognard, C.; Bender, A.; Dumas, M.; Weber, M.; Bruneau, A.; David, L.; Savatier, P.; Bourillot, P.-Y.

10.1101/2025.04.09.647577 — cell biology — Posted on 2025-04-10

3388 Tff2 marks gastric corpus progenitors that give rise to pyloric metaplasia/SPEM following injury

Tu, R.; Zheng, H.; Zheng, B.; Zhong, Q.; Qian, J.; Wu, F.; Shiokawa, T.; Ochiai, Y.; Kobayashi, H.; Waterbury, Q. T.; Zamechek, L. B.; Takahashi, S.; Mizuno, S.; Huang, C.; Li, P.; Hayakawa, Y.; Wang, T. C.

10.1101/2025.04.09.647847 — cell biology — Posted on 2025-04-10

3389 A Multimodal Imaging Pipeline for the Discovery of Molecular Markers of Cellular Neighborhoods

Pham, T.; Farrow, M. A.; Migas, L. G.; Dufresne, M.; Colley, M. E.; Allen, J. L.; de Caestecker, M.; Van de Plas, R.; Spraggins, J. M.

10.1101/2025.04.07.647675 — molecular biology — Posted on 2025-04-10

3390 MLO-mediated Ca2+ influx regulates root hair tip growth in Arabidopsis

Ogawa, S. T.; Zhang, W.; Staiger, C. J.; Kessler, S. A.

10.1101/2025.04.08.647801 — plant biology — Posted on 2025-04-10

3391 Phloem-Specific Translational Regulation of Soybean Nodulation: Insights from a Phloem-Targeted TRAP-Seq Approach

Song, J. h.; Agake, S.-i.; Tanabata, S.; Cui, Y.; Su, L.; Montes-Luz, B.; Xu, D.; Stacey, G.

10.1101/2025.04.09.647652 — plant biology — Posted on 2025-04-10

3392 Anisotropic diffuse growth in Arabidopsis stigma papillae

Davis, T. C.; Kessler, S. A.

10.1101/2025.04.08.647848 — plant biology — Posted on 2025-04-10

3393 Mechanisms controlling the plasma membrane targeting and the nanodomain organization of the plant SPFH protein HIR2

Danek, M.; Hdedeh, O.; Boutet, J.; Safi, H.; Abuzeineh, A.; Martin Barranco, A.; Fiche, J.-B.; Mercier, C.; Nollmann, M.; BOUTTE, Y.; Santoni, V.; MONGRAND, S.; Martiniere, A.; Zelazny, E.

10.1101/2025.04.10.648198 — plant biology — Posted on 2025-04-10

3394 CEPR2 perceives group II CEPs to regulate cell surface immunity in Arabidopsis

Rzemieniewski, J.; Zecua-Ramirez, P.; Schade, S.; Camgöz, Z.; Haljiti, G.; Kaur, S.; Ludwig, C.; Hückelhoven, R.; Stegmann, M.

10.1101/2025.04.10.648145 — plant biology — Posted on 2025-04-10

3395 Thermotropic Properties of Large, Circularized Nanodiscs

Arcario, M. J.; Dalal, V.; Fan, D.; Cheng, W. W.-L.

10.1101/2025.04.07.647641 — biophysics — Posted on 2025-04-10

3396 Real-time tracking of mRNP complex assembly reveals various mechanisms that synergistically enhance translation repression

Payr, M.; Meyer, J.; Geissen, E.-M.; Hennig, J.; Duss, O.

10.1101/2025.04.07.647595 — biophysics — Posted on 2025-04-10

3397 Mechanical and morphological features of the cockroach antenna confer flexibility, reveal a kinematic chain system and predict strain information for proprioception

Meng, L.; McDonnell, P.; Jayaram, K.; Mongeau, J.-M.

10.1101/2025.04.07.647640 — biophysics — Posted on 2025-04-10

3398 Advanced coarse-grained model for fast simulation of nascent polypeptide chain dynamics within the ribosome

Yu, S.; Kushner, A.; Teasell, E.; Zhao, W.; Srebnik, S.; Duc, K. D.

10.1101/2025.04.08.647858 — biophysics — Posted on 2025-04-10

3399 SISE, free LabView-based software for ion flux measurements

Ahmad, N.; Tennakoon, K.; Hedrich, R.; Huang, S.; Roelfsema, R.

10.1101/2025.04.09.647937 — biophysics — Posted on 2025-04-10

3400 The ribosome directs nascent chains through two folding-dependent pathways

Mitropoulou, A. N.; Wlodarski, T. N.; Streit, J. O.; Chan, S. H. S.; Plessa, E.; Woodburn, L. F.; Cabrita, L. D.; Christodoulou, J.

10.1101/2025.04.08.647855 — biophysics — Posted on 2025-04-10

3401 Robust detection of specific epistasis using rank statistics

Carlson, M. O.; Andrews, B. L.; Simons, Y. B.

10.1101/2025.04.08.647864 — biophysics — Posted on 2025-04-10

3402 GRAPEVINE: A Reinforcement Failing Framework for AI-Guided Discovery of Hidden Spatial Dynamics in Adaptive Tumor Therapy

Aif, S.; Eiche, M.; Appold, N.; Fischer, E.; Citak, T.; Kayser, J.

10.1101/2025.04.08.647768 — biophysics — Posted on 2025-04-10

3403 Breaking barriers: A new phytomedicine based treatment approach for targeted unrevealed non-canonical DNA structures in tuberculosis bacteria.

Bhowmik, S.; Shroff, T.; Bag, S.; Kadam, P.; Mistry, N.

10.1101/2025.04.08.647720 — biophysics — Posted on 2025-04-10

3404 Modelling Actin-MT Crosstalk in Migrating Cells

Nayak, P.; Dasanna, A. K.; Paul, R.; Rieger, H.

10.1101/2025.04.09.647914 — biophysics — Posted on 2025-04-10

3405 Functionally-Coupled Ion Channels Begin Co-assembling at the Start of Their Synthesis

Pournejati, R.; Huang, J. M.; Ma, M.; Moreno, C. M.; Vivas, O.

10.1101/2025.04.08.647703 — biophysics — Posted on 2025-04-10

3406 Menger_Curvature : a MDAKit implementation to decipher the dynamics, curvatures and flexibilities of polymeric backbones at the residue level

Reboul, E.; Marien, J.; Prevost, C.; Taly, A.; Sacquin-Mora, S.

10.1101/2025.04.04.647214 — bioinformatics — Posted on 2025-04-10

3407 Label-free droplet image analysis with Cellprofiler

Kacsor, D.; Saar-Abroi, M.; Olman, T.; Bartkova, S.; Scheler, O.

10.1101/2025.04.04.647160 — bioinformatics — Posted on 2025-04-10

3408 Impact of Long-Term Mercury Contamination on the Rhizosphere Microbiota of Lotus tenuis: A Pathway to Resilience via Interkingdom Facilitation

Tiodar, E. D.; Vacar, C. L.; Grimm, M. C.; Ganea, I. V.; Balazs, Z. R.; Abrudan, A. M.; Timar, C.; Tantau, I.; Banciu, M.; Angel, R.; Podar, D.

10.1101/2025.04.07.647525 — ecology — Posted on 2025-04-10

3409 Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomers

Hnath, B.; Dokholyan, N. V.

10.1101/2025.04.07.647611 — molecular biology — Posted on 2025-04-10

3410 The leader proteins of Theiler's virus and Boone cardiovirus use a combination of Short Linear Motifs (SLiMs) to target RSK kinases to the nuclear pore complex.

Lizcano-Perret, B.; Wavreil, F.; Veinstein, M.; Duflos, C.; Milcamps, R.; Sorgeloos, F.; Michiels, T.

10.1101/2025.04.09.647954 — microbiology — Posted on 2025-04-10

3411 Age-dependent expression and antiviral activity of interferon epsilon in respiratory epithelium

McCabe, M.; Groves, H. E.; Getty, E.; Campbell, E.; Bamford, C. G. G.; Lopez Campos, G.; Shields, M. D.; Power, U. F.

10.1101/2025.04.08.647778 — microbiology — Posted on 2025-04-10

3412 Langerhans Cells Regulate Tongue Intraepithelial Innervation in a Microbiota- and Age-Dependent Manner

Netanely, Y.; Saba, Y.; Naamneh, R.; Yacoub, S.; Jaber, Y.; Raviv, A.; Eli-Berchoer, L.; Shapiro, H.; Elinav, E.; Wilensky, A.; Clausen, B. E.; Hovav, A.-H.

10.1101/2025.04.03.647024 — immunology — Posted on 2025-04-10

3413 Skin development and metamorphic re-arrangement in Arthroleptella villiersi Hewitt, 1935 reveals distinct heterochronic patterns in anurans with different life histories

Naumann, B.; Schweiger, S.; Mueller, H.

10.1101/2025.04.06.647201 — zoology — Posted on 2025-04-10

3414 treecompareR: Tree Visualizations of Chemical Space

Kruse, P. M.; Ring, C. L.

10.1101/2025.04.04.647092 — pharmacology and toxicology — Posted on 2025-04-10

3415 Simplified and refined murine model of reversible aortic constriction for characterizing cardiac functional recovery

Ghajar-Rahimia, E.; Sicard, P.; Castel, L.; Goergen, C. J.; Moore-Morris, T.

10.1101/2025.04.05.646758 — pathology — Posted on 2025-04-10

3416 Altair-LSFM: A High-Resolution, Easy-to-Build Light-Sheet Microscope for Sub-Cellular Imaging

Haug, J.; Gałecki, S.; Dean, K. M.

10.1101/2025.04.08.647739 — biophysics — Posted on 2025-04-10

3417 An inertial sensor-based comprehensive analysis of manual wheelchair user mobility during daily life in people with SCI

Pinnock Branford, K.; Van Straaten, M. G.; Jahanian, O.; Morrow, M. M. B.; Cain, S. M.

10.1101/2025.04.02.646948 — bioengineering — Posted on 2025-04-10

3418 VP-CLEM-Kit: An accessible pipeline for visual proteomics using super resolution volume correlative light and electron microscopy (SR-vCLEM)

Lumkwana, D.; Lightley, J.; Vesga, A. G.; de Folter, J.; Domart, M.-C.; Maclachlan, C.; Kumar, S.; Evans, J. R.; Peddie, C.; Burrell, A.; Yoshimura, A.; Mangali, A.; Vahrjmeijer, N.; Bhaga, M.; Smit, C.; Titze, B.; Horrocks, M. H.; Cobra Straker, L.; Garcia, E.; Jones, M. L.; Mclean, A.; Roufosse, C.; Loos, B.; Gandhi, S.; Strange, A.; Henriques, R.; French, P. M.; Collinson, L.

10.1101/2025.04.08.647770 — cell biology — Posted on 2025-04-10

3419 Small non-coding RNAs encapsulating mammalian cells fuel innate immunity

hu, l.; Jiang, X.; Xu, C.; Yang, E.; Xu, D.; Peng, Y.; Han, X.; Si, J.; Shao, Q.; Liu, Z.; Chen, Q.; He, W.; He, S.; Xu, Y.; He, C.; Huang, X.

10.1101/2025.04.07.647669 — molecular biology — Posted on 2025-04-10

3420 Characterization of a Novel FKS1 Mutation in Candida lusitaniae Shows a Potential Critical Role for MKC1 in Echinocandin Resistance

Accoceberry, I.; Lefranc, M.; meunier, C.; Quiles, F.; Kordalewska, M.; Biteau, N.; Perlin, D. S.; El Kirat Chatel, S.; Noël, T.

10.1101/2025.04.08.647726 — microbiology — Posted on 2025-04-10

3421 Coumarins disrupt cell-cell communication for control of pathogenesis and virulence in ESKAPEEs and fungal opportunists

Boon, D.; O'Rourke, B.; Carmody, M.; Woods, D. F.; Gloe, A.; Platero-Rochart, D.; Sanchez-Murcia, P. A.; McGlacken, G.; Reen, F. J.

10.1101/2025.04.09.647955 — microbiology — Posted on 2025-04-10

3422 Single-cell SNP-DNA sequencing precisely maps genotoxic events in CRISPR-edited primary cells

Boutin, J.; FAYET, S.; MARIN, V.; BERGES, C.; Riandiere, M.; Toutain, J.; Lamrissi-Garcia, I.; THIBAULT, C.; Cappellen, d.; Dabernat, S.; Poulet, A.; Francilette, M.; DROUIN, N.; MOREAU-GAUDRY, F.; BEDEL, A.

10.1101/2025.04.04.647179 — bioengineering — Posted on 2025-04-10

3423 NALCN/Cch1 channelosome subunits originated in early eukaryotes and are fully conserved in animals, fungi, and apusomonads

Senatore, A.; Mayorova, T. D.; Yanez Guerra, L. A.; Elkhatib, W.; Bejoy, B.; Lory, P.; Monteil, A.

10.1101/2025.04.04.647097 — evolutionary biology — Posted on 2025-04-10

3424 A national assessment of waterbird hunting in coastal wetlands of Suriname, south America

Mizrahi, D. S.; Spaans, A. L.; Spaans-Scheen, M. J.; Cox, A. R.; Laliberte, B.; Gallo-Cajiao, E.; Roy, C.

10.1101/2025.04.04.646930 — ecology — Posted on 2025-04-10

3425 Contributions of T helper 9 cells in endometriosis-associated inflammation and lesion growth

McCallion, A.; Zutautas, K.; Sisnett, D.; Yolmo, P.; Lingegowda, H.; Ravishanker, A.; Hoang, D. V.; Tayade, C.

10.1101/2025.04.04.647212 — immunology — Posted on 2025-04-10

3426 Altered systemic bioenergetic reserve in chronic kidney disease predisposes hearts to worse functional outcomes

Young, M.; Aastrup, M.; Patel, N.; Cullen, F.; Hansen, E. S. S.; Clark, J. E.; Eykyn, T. R.; Vaeggemose, M.; Vujic, A.; Karatzia, L.; Valkovic, L.; Miller, J. J. J. J.; Buus, N. H.; Laustsen, C.; Yaqoob, M. M.; Aksentijevic, D.

10.1101/2024.10.24.620055 — physiology — Posted on 2025-04-10

3427 Cold-activated hepatocyte derived exosomes promote BAT thermogenesis through miR-293-5p

Gao, X.; Xu, J.; Xu, Z. q.; Jiang, M.; Zhu, J.; Geng, Y.; Dong, S.; Zhou, Z.; Li, Y. n.; Xu, Y. J.

10.1101/2025.04.04.647213 — genetics — Posted on 2025-04-10

3428 Quartet-based Genome-scale Species Tree Inference using Multicopy Gene Family Trees

Rafi, A.; Rumi, A. M. S.; Hakim, S. A.; Bayzid, M. S.

10.1101/2025.04.04.647228 — evolutionary biology — Posted on 2025-04-10

3429 Scraping the Surface: First Records of Cleaning Associations Between Sharks and Oceanic Manta Rays

Vinesky, J.; Ketchum, J.; Hoyos, M.

10.1101/2025.04.04.647128 — ecology — Posted on 2025-04-10

3430 Enhancement of Chikungunya virus genome replication in mammalian cells at a sub-physiological temperature

Guo, J.; Lin, A. E.; Aditya, C.; Ploss, A.; Harris, M.

10.1101/2021.09.29.462334 — microbiology — Posted on 2025-04-10

3431 Dopamine and temporal discounting: revisiting pharmacology and individual differences

Smith, E.; Theis, H.; van Eimeren, T.; Knauth, K.; Tuzsus, D.; Zhang, L.; Mathar, D.; Peters, J.

10.1101/2024.08.28.610170 — neuroscience — Posted on 2025-04-10

3432 Differences in Cajal-Retzius cell density and postnatal persistence across cortical areas revealed by a novel intersectional genetic labeling approach

Moan, K.; Machold, R. P.; Quattrocolo, G.

10.1101/2025.04.09.647949 — neuroscience — Posted on 2025-04-10

3433 Homeostatic regulation across fast and slow timescales through aggregate synaptic dynamics

Vlachos, P. E.; Triesch, J.

10.1101/2025.04.10.648137 — neuroscience — Posted on 2025-04-10

3434 Reduced glutathione levels in Enterococcus faecalis trigger metabolic and transcriptional compensatory adjustments during iron exposure.

Aliaga-Tobar, V. M.; Torres, J.; Mendoza, S.; Galvez, G.; Ortega, J.; Gomez, S.; Parra, V.; Arenas, F.; Maass, A. E.; Siegel, A.; Gonzalez, M.; Latorre, M. A.

10.1101/2025.04.04.647250 — systems biology — Posted on 2025-04-10

3435 Palmdelphin facilitates R-spondin2 secretion to activate Wnt signaling and promote colorectal cancer stemness and tumorigenesis

Yang, Y.; Shi, J.; Yang, Y.; Liu, S.; Li, Y.; Feng, L.; Yan, R.; Yao, J.; Chen, L.; Ding, L.; Zhang, Z.; Feng, H.; Chen, H.; Lu, Q.; Yan, T.; Yan, Z.; Chandrakesan, P.; Qu, D.; Du, J.; Cao, Z.; Peng, J.; Weygant, N.

10.1101/2025.04.03.646911 — cancer biology — Posted on 2025-04-10

3436 Exploring Mechanisms of Early Acquired Resistance to Doxorubicin in Melanoma in 3D Model

Negrea, G. G.; Balacescu, L.; Pavel, O.; Rauca, V.; Dume, B.; Licarete, E.; Patras, L.; Banciu, M.; Sesarman, A.

10.1101/2025.04.07.646990 — cancer biology — Posted on 2025-04-10

3437 Tracing the stemness and malignant transition in a heritable colorectal cancer Lynch Syndrome by single-cell RNA-seq analysis

CAI, Z.; Xu, J.; Li, Y.; Wang, Z.; Li, Q.; Liu, A.; Sheng, J.; Yang, L.; Dong, G.

10.1101/2025.04.06.647495 — cancer biology — Posted on 2025-04-10

3438 ReScale4DL: Balancing Pixel and Contextual Information for Enhanced Bioimage Segmentation

Ferreira, M. G.; Saraiva, B. M.; Brito, A. D.; Pinho, M. G.; Henriques, R.; Gomez-de-Mariscal, E.

10.1101/2025.04.09.647871 — biophysics — Posted on 2025-04-10

3439 Mechanical properties of adherent cell sheets analyzed by deflection of supporting membrane

Efremov, Y. M.; Subbot, A. M.; Novikov, I. A.; Avetisov, S. E.; Timashev, P. S.

10.1101/2025.04.03.647015 — biophysics — Posted on 2025-04-10

3440 Exo-Tox: Identifying Exotoxins from secreted bacterial proteins

Krueger, T.; Durmaz, D. A.; Jimenez Soto, L. F.

10.1101/2025.04.04.647182 — bioinformatics — Posted on 2025-04-10

3441 Generating three-dimensional genome structures with a variational quantum algorithm

Siciliano, A. J.; Wang, Z.

10.1101/2025.04.06.647452 — bioinformatics — Posted on 2025-04-10

3442 On the Genetic Origins of Phenotypes in Genome-Wide Association Studies: The SNP Allocation For Estimating Heritability (SAFE-h2) Tool to Explore Additive-only Allelic Effects or Additive and Non-Additive Allelic Effects

Darbani, B.; Nicolaisen, M.

10.1101/2023.08.28.555092 — bioinformatics — Posted on 2025-04-10

3443 AlphaFold predictions on whole genomes at a glancee: a coherent view on packing properties, pLDDT values, and disordered regions

Cazals, F.; Sarti, E.

10.1101/2024.11.16.623929 — bioinformatics — Posted on 2025-04-10

3444 Correlated evolution of the neck, head and forelimb across the theropod-bird transition

Marek, R. D.; Felice, R. N.

10.1101/2025.04.04.647043 — evolutionary biology — Posted on 2025-04-10

3445 A conserved differentiation program facilitates inhibitory neuron production in the developing mouse and human cerebellum

Christensen, J. B.; Donovan, A. P. A.; Moradi, M.; Vanacore, G.; Helmy, M.; Reid, A. J.; Lee, J. T. H.; Bayraktar, O. A.; Brand, A. H.; Bayin, N. S.

10.1101/2025.04.10.648162 — developmental biology — Posted on 2025-04-10

3446 Parkinson's Disease-Linked Kir4.2 Mutation R28C Leads to Loss of Ion Channel Function

Chen, X.; Finol-Urdaneta, R. K.; Chen, M.; Sykes, A.; Gao, B.; Adams, D. J.; Mellick, G. D.; Ma, L.

10.1101/2024.05.05.592599 — cell biology — Posted on 2025-04-10

3447 Lysosomal cathepsin D regulates bone turnover through distinct mode of actions of the autophagy pathways in osteoblasts and osteoclasts

Zhang, F.; Zhao, Y.; He, Q.; Schneider, L. E.; Zhang, J.; Wan, C.

10.1101/2025.04.09.645406 — cell biology — Posted on 2025-04-10

3448 Pro-neurogenic potential of blood cells cultured in autologous plasma

Arora, R.; Bhardwaj, A.; Panda, N. K.; Das, R.; Sinharay, S.; Patkulkar, P.; Gupta, T.; Bakshi, J.; Virk, R.; Nayak, G.; Patro, S. K.; Bhadada, S.; Pal, A.; Pal, R.; Chhabra, S.; Chhabra, S.; Pal, M.; Rashid, S.; SHARMA, M.

10.1101/2025.03.19.643269 — cell biology — Posted on 2025-04-10

3449 Spatial Analysis of Placentae During Congenital Cytomegalovirus Infection Reveals Distinct Cellular Profiles in Immune Cells and Trophoblasts

Sintim-Aboagye, E.; Quach, H. Q.; Sherman, W.; Farnan, S.; Otrubova, K.; Verma, N.; Littlefield, D.; Punia, S.; Johnson, E.; Blackstad, M.; Schleiss, M.; Norgan, A.; Gray, C.; Enninga, E. A. L.; Chakraborty, R.

10.1101/2025.04.04.647170 — immunology — Posted on 2025-04-10

3450 Oral OM-89 in combination with antibiotics prevents recurrent infection in a mouse model of urinary tract infection

Canton, T.; Durand, M.; Baulier, E.; Pasquali, C.; Calin, R.; Ingersoll, M. A.; Rousseau, M.

10.1101/2025.04.04.647233 — immunology — Posted on 2025-04-10

3451 Trends in Self-citation Rates in High-impact Neurology, Neuroscience, and Psychiatry Journals

Rosenblatt, M.; Mehta, S.; Peterson, H.; Dadashkarimi, J.; Rodriguez, R. X.; Foster, M. L.; Adkinson, B. D.; Liang, Q.; Kimble, V. M.; Ye, J.; McCusker, M. C.; Farruggia, M. C.; Rolison, M.; Westwater, M. L.; Jiang, R.; Noble, S.; Scheinost, D.

10.1101/2022.09.27.509533 — neuroscience — Posted on 2025-04-10

3452 V1 superficial layers create a saliency map that feeds forward to the parietal cortex for attentional guidance

Liu, C.; Liu, C.; Huber, L.; Zhaoping, L.; Zhang, P.

10.1101/2025.04.10.648136 — neuroscience — Posted on 2025-04-10

3453 Vesicle-mediated oxytocin release drives melanocortin circuit maturation during a neonatal critical period

Barelle, P.-Y.; Schaller, F.; Park, S.; Caron, E.; Klucznik, J.; Ciofi, P.; Muscatelli, F.; Bouret, S. G.

10.1101/2025.04.10.648134 — neuroscience — Posted on 2025-04-10

3454 Transcription factor LHX2 suppresses astrocyte proliferation in the postnatal mammalian cerebral cortex

Iyer, A.; Fronteiro, R.; Bhatia, P.; Kumari, S.; Singh, A.; Zhou, J.; Bocchi, R.; Narayanan, R.; Tole, S.

10.1101/2025.04.10.648067 — neuroscience — Posted on 2025-04-10

3455 Distinct neural bases of subcomponents of the attentional blink

Halder, S.; Raya, D. V.; Sridharan, D.

10.1101/2024.03.04.583330 — neuroscience — Posted on 2025-04-10

3456 Synapses drive local mitochondrial ATP synthesis to fuel plasticity

Ghosh, I.; Fan, R.; Shah, M.; Bapat, O.; Rangaraju, V.

10.1101/2025.04.09.648032 — neuroscience — Posted on 2025-04-10

3457 Noradrenergic-dependent restoration of visual discrimination in a mouse model of SYNGAP1-related disorder

Katsanevaki, D.; Dupuy, N.; Booker, S. A.; Wright, D.; Kenny, A.; Chen, Z.; Kudryashova, N.; Howitt, P.; Stanfield, A. C.; Kind, P. C.; Rochefort, N. L.

10.1101/2025.04.09.647923 — neuroscience — Posted on 2025-04-10

3458 The representation of regularity and randomness in auditory cortex of awake rats

Bashari, S.; Jankowski, M. M.; Nelken, I.

10.1101/2025.04.09.647967 — neuroscience — Posted on 2025-04-10

3459 Lateral Hypothalamic Glutamate and GABA Neurons Cooperatively Shape Striatum-Wide Dopamine Dynamics During Consumption

Gordon-Fennell, A.; Benowitz, B. M.; Barbakh, J. M.; Montequin, I.; Campuzano, A.; Stevenson, H. P.; Lu, E.; Hjort, M. M.; Ancell, E.; Critz, M.; Witten, D.; Stuber, G.

10.1101/2025.04.09.648052 — neuroscience — Posted on 2025-04-10

3460 Divalent siRNA for prion disease

Gentile, J. E.; Corridon, T. L.; Serack, F. E.; Echeverria, D.; Kennedy, Z. E.; Gallant-Behm, C. L.; Hassler, M. R.; Kinberger, G.; Kamath, N. G.; Lian, Y.; Gross, K. Y.; Miller, R.; DeSouza-Lenz, K.; Howard, M.; Guzman, K.; Chan, N.; Laversenne, V.; Curtis, D. T.; Fettes, K.; Lemaitre, M.; Cappon, G.; Jackson, A. L.; Yamada, K.; Alterman, J. F.; Coffey, A. A.; Minikel, E. V.; Khvorova, A.; Vallabh, S. M.

10.1101/2024.12.05.627039 — neuroscience — Posted on 2025-04-10

3461 MdAGG apple lectins in Fire Blight resistance: CRISPR/Cas9 validation and their potential for intragenesis approaches.

Bodelot, A.; Dousset, N.; Ravon, E.; Heintz, C.; Brisset, M.-N.; Degrave, A.; VERGNE, E.

10.1101/2024.11.08.622591 — plant biology — Posted on 2025-04-10

3462 Exploiting Pseudomonas syringae Type 3 secretion to study effector contribution to disease in spinach

Mendel, M.; Zuijdgeest, X.; Berg, F. v. d.; Meer, L. v. d.; Elberse, J.; Skiadas, P.; Seidl, M.; Ackerveken, G. v. d.; Jonge, R. d.

10.1101/2024.06.14.599008 — plant biology — Posted on 2025-04-10

3463 Immune cells employ intermittent integrin-mediated traction forces for 3D migration

Czerwinski, T.; Bischof, L.; Böhringer, D.; Kara, S.; Strissel, P. L.; Strick, R.; Winterl, A.; Gerum, R.; Wittmann, E.; Schneider, M.; Beckmann, M. W.; Nusser, G.; Wiesinger, M.; Budday, S.; Lux, A.; Voskens, C.; Fabry, B.; Mark, C.

10.1101/2023.04.20.537658 — biophysics — Posted on 2025-04-10

3464 Bridging data gaps: predicting inadequate micronutrient intake with machine learning

Voukelatou, V.; Tang, K.; Lauzana, I.; Jangid, M.; Martini, G.; de Pee, S.; Knight, F.; Piovani, D.

10.1101/2025.04.08.647715 — bioinformatics — Posted on 2025-04-10

3465 Hidden network preserved in Slide-tags data allows reference-free spatial reconstruction

Dahlberg, S. K.; Bonet, D. F.; Franzen, L.; Stahl, P. L.; Hoffecker, I. T.

10.1101/2024.06.16.598614 — bioinformatics — Posted on 2025-04-10

3466 Structural analysis of tilvestamab in complex with AXL

Christakou, E.; Lopez, A. J.; Muruganandam, G.; Micklem, D.; Lorens, J. B.; Kursula, P.

10.1101/2024.12.04.626834 — biochemistry — Posted on 2025-04-10

3467 TweetyBERT: Automated parsing of birdsong through self-supervised machine learning.

Vengrovski, G.; Hulsey-Vincent, M. R.; Bemrose, M. A.; Gardner, T. J.

10.1101/2025.04.09.648029 — animal behavior and cognition — Posted on 2025-04-10

3468 Genomic prediction of stalk lodging resistance and the associated intermediate phenotypes in maize using whole-genome resequence and multi-environmental data

Machado e Silva, C.; Kunduru, B.; Bokros, N.; Tabaracci, K.; Oduntan, Y.; Brar, M. S.; Kumar, R.; Stubbs, C. J.; Nardino, M.; McMahan, C. S.; DeBolt, S.; Robertson, D. J.; Sekhon, R. S.; Morota, G.

10.1101/2025.04.06.647466 — genetics — Posted on 2025-04-10

3469 EnviroAmpDesigner, a tool for designing high specificity multiplex PCR primer panels for detecting and subtyping a target organism in environmental surveillance samples

Spadar, A.; Mahindroo, J.; Troman, C.; Owusu, M.; Abu-Sarkodie, Y.; Owusu-Dabo, E.; Abraham, D.; Benny, B.; Govindan, K.; Mohan, V. R.; Dyson, Z. A.; Grassly, N.; Holt, K. E.

10.1101/2025.04.10.648097 — bioinformatics — Posted on 2025-04-10

3470 OBE-DB: A Computational Tool and Web Server for the Prediction of Antiobesity Drugs

Murcia-Garcia, E.; Martinez-Cortes, C.; Banegas-Luna, A. J.; Hernandez-Morante, J. J.; Perez-Sanchez, H.

10.1101/2025.04.10.648110 — bioinformatics — Posted on 2025-04-10

3471 Two telomere-to-telomere, gap-free genome assemblies and comparisons revealed the conserved key genes associated with sugar accumulation in Rubus genus

Li, X.; Han, X.; Liu, S.; Zhang, Q.; Guan, J.; Tang, Y.; Zhang, M.; Lian, H.; Xu, P.; Zheng, M.; Li, K.; Sun, G.; Sun, Y.; Dong, Y.; Lin, X.; Liang, Y.; Wang, Z.; Qin, G.; Li, B.; Zhou, H.; Yang, G.; Liu, Z.; He, H.; Zhou, J.

10.1101/2025.04.09.646780 — genomics — Posted on 2025-04-10

3472 Shared genomic architecture of the brain white matter structural connectome and intelligence

Dong, X.; Huang, W.; Chen, H.; Zhang, Y.; Liu, B.; Shu, N.

10.1101/2025.04.09.647917 — genomics — Posted on 2025-04-10

3473 Aevol-9: A simulation platform to decipher the evolution of genome architecture

Luiselli, J.; Parsons, D.; Galle, R.; Banse, P.; Rouzaud-Cornabas, J.; Beslon, G.

10.1101/2025.04.10.648095 — evolutionary biology — Posted on 2025-04-10

3474 Assessing Immune Stability in Space: Haematological and T Cell Profiling of Astronauts During the MESSAGE Science Mission in Axiom-3 on the ISS

Tastan, C.; Gulden, G.; Demir, O.; Cam, E.; Erkek, F.; Sert, B.; Gozler, T.; Yuksel, I.; Tekirdagli, B.

10.1101/2025.04.09.647940 — molecular biology — Posted on 2025-04-10

3475 Impact of Single Freeze-Thaw Cycles on Serum Protein Stability: Implications for Clinical Biomarker Validation Using Mass Spectrometry

Sauer, T.; Oberländer, M.; Maushagen, R.; Radloff, H.; Braun, R.; Honselmann, K.; Wellner, U.; Habermann, J.; Benecke, C.; Keck, T.; Gemoll, T.

10.1101/2025.04.09.647925 — molecular biology — Posted on 2025-04-10

3476 Mechanism of clinically relevant neurosecretory and metabolic impairment in Alzheimers and identification of engineered nanotherapy

Shang, Y.; Cho, W. J.; Munj, S. A.; Jena, S. G.; Arslanturk, S.; Patil, S. R.; Qi, X.; Jena, B. P.

10.1101/2025.04.09.647859 — neuroscience — Posted on 2025-04-10

3477 First record of Argulus japonicus infestation onCyprinus carpio in Hungary, and the first descriptionof Argulus japonicus subsp. europaeus subsp. nov.Keve, 2025

Keve, G.; Toth, A. G.; Katics, M.; Baska, F.; Eszterbauer, E.; Hornok, S.; Solymosi, N.

10.1101/2025.04.09.647856 — zoology — Posted on 2025-04-10

3478 STEAMBOAT: Attention-based multiscale delineation of cellular interactions in tissues

Liang, S.; Tang, J.; Wang, G.; Ma, J.

10.1101/2025.04.06.647437 — bioinformatics — Posted on 2025-04-10

3479 MENDELSEEK: An algorithm that predicts Mendelian Genes and elucidates what makes them special

Zhou, H.; Skolnick, J.

10.1101/2025.04.06.647432 — genomics — Posted on 2025-04-10

3480 The protease interpain A of Prevotella intermedia promotes human oral squamous cell carcinoma cells proliferation and migration

Chang, S.-M.; Huang, I.-H.; Ciou, Y.-J.; Wang, W.-R.; Wu, N.-H.; Chuu, C.-P.; Hsiao, J.-R.; Chang, J. S.; Chang, J.-Y.; Chen, J.-W.

10.1101/2024.10.20.619282 — cancer biology — Posted on 2025-04-10

3481 H3K27M Mutation Reshapes the Antigenic Landscape in Diffuse Midline Glioma

Shamekhi, T.; Zeng, B.; Sun, C. X.; Daniel, P.; Lim Kam Sian, T. C. C.; Goncalves, G.; Huang, G.; Fahimi, F.; Selvakumar, N.; Tanuwidjaya, E.; Woodhouse, I.; Kritzer, B.; Schittenhelm, R. B.; Mazzieri, R.; Cain, J. E.; Nazarin, J.; Hansford, J. R.; Firestein, R.; Dolcetti, R.; Faridi, P.

10.1101/2025.04.07.647502 — cancer biology — Posted on 2025-04-10

3482 DeorphaNN: Virtual screening of GPCR peptide agonists using AlphaFold-predicted active-state complexes and deep learning embeddings

Ferguson, L.; Ouellet, S.; Vandewyer, E.; Wang, C.; Wunna, Z.; Lim, T. K. Y.; Schafer, W. R.; Beets, I.

10.1101/2025.03.19.644234 — bioinformatics — Posted on 2025-04-10

3483 WITHDRAWN: Gap-App: A sex-distinct AI-based predictor for pancreatic ductal adenocarcinoma survival as a web application open to patients and physicians

Ojha, A.; Zhao, S.-J.; Akpunonu, B.; Zhang, J.-T.; Simo, K. A.; Liu, J.-Y.

10.1101/2024.06.04.597246 — bioinformatics — Posted on 2025-04-10

3484 Integrative Single-Cell RNA and ATAC Sequencing Reveals the Impact of Chronic Cigarette Smoking on Lung Epithelial Responses to Influenza and Hyperoxia

Cha, P.-C.; Zou, Z.; Nouws, J.; Dela Cruz, C.; Sharma, L. K.; Yan, X.; Sauler, M.

10.1101/2025.04.06.647429 — bioinformatics — Posted on 2025-04-10

3485 ST-FFPE-mIF: Integrating Spatial Transcriptomics and Multiplex Immunofluorescence in Formalin-Fixed Paraffin-Embedded Tissues Using Stereo-seq

Zhang, X.; Zhang, M.; Xu, Y.; Song, Y.; Yang, X.; Wu, Y.; Zhao, X.; Ran, D.; Liu, X.; Huang, H.; Lei, W.; Li, H.; Zhang, Y.; Xi, F.; Li, G.; Liu, X.; Xu, L.; Chen, A.; Liao, S.; Zhang, J. j.

10.1101/2025.01.24.634655 — biochemistry — Posted on 2025-04-10

3486 Neural correlates of image memorability: Combining large-scale 7T fMRI with machine learning-based predictions

Maki-Marttunen, V.; Hagen, T.; Espeseth, T.

10.1101/2025.04.06.647493 — animal behavior and cognition — Posted on 2025-04-10

3487 The evolution of sequence specificity in a DNA binding protein family

Nandy, M.; Krishnaswamy, M.; Sharda, M.; Seshasayee, A. S. N.

10.1101/2024.06.24.600358 — evolutionary biology — Posted on 2025-04-10

3488 The Evolutionary Flexibility of the Drosophila Circadian Clock: Network Constraints or Adaptive Freedom?

Creasey, L. D.; Tauber, E.

10.1101/2025.04.02.646778 — evolutionary biology — Posted on 2025-04-10

3489 IBDome: An integrated molecular, histopathological, and clinical atlas of inflammatory bowel diseases

Plattner, C.; Sturm, G.; Kuehl, A. A.; Atreya, R.; Carollo, S.; Gronauer, R.; Rieder, D.; Guenther, M.; Ormanns, S.; Manzl, C.; Wirtz, S.; Meneghetti, A. R.; Hegazy, A.; Patankar, J. V.; Carrero, Z. I.; TRR241 IBDome Consortium, ; Neurath, M. F.; Kather, J. N.; Becker, C.; Siegmund, B.; Trajanoski, Z.

10.1101/2025.03.26.645544 — molecular biology — Posted on 2025-04-10

3490 Longitudinal study of the udder microbiome of Norwegian red dairy cows using metataxonomic and shotgun metagenomic approaches: Insights into pathogen-driven microbial adaptation and succession

Da Silva Duarte, V.; Franklin, F.; Krysmann, A. M.; Porcellato, D.

10.1101/2025.04.04.647183 — microbiology — Posted on 2025-04-10

3491 Ternary Neurexin-T178-PTPR complexes represent a presynaptic core-module of neuronal synapse organization

Thivaios, S.; Schwenk, J.; Brechet, A.; Boudkkazi, S.; Sethumadhavan, N.; Henneken, P.; Miura, E.; Hayashi, A.; Kocylowski, M. K.; Haupt, A.; Kaminski, D.; Schreiner, D.; van den Broucke, J.-B.; Kulik, A.; Schulte, U.; Sterky, F. H.; Yuzaki, M.; Scheiffele, P.; Fakler, B.

10.1101/2024.07.16.603715 — neuroscience — Posted on 2025-04-10

3492 ER Ca2+-levels control neuromodulator secretion by regulating L-type Ca2+-channel activity via its STIM1-interacting domain

Hoogstraaten, R. I.; Toonen, R. F.; Verhage, M.

10.1101/2024.11.12.623153 — neuroscience — Posted on 2025-04-10

3493 Disentangling acute motor deficits and adaptive responses evoked by the loss of cerebellar output

Sinha, N.; Israely, S.; Ben Harosh, O.; Harel, R.; Dewald, J.; Prut, Y.

10.1101/2024.05.21.595172 — neuroscience — Posted on 2025-04-10

3494 Deficient Memory, Long-Term Potentiation and Hippocampal Synaptic Plasticity in Galectin-4-Deficient Mice

Brocca, M. E.; Mora-Rubio, A.; Alonso-Calvino, E.; Fernandez-Lopez, E.; Diez-Revuelta, N.; Guirado-Calatrava, J. C.; Alvarez-Velez, R.; Dopazo, A.; Lopez-Merino, E.; Martos-Punal, D.; Esteban, J. A.; Aguilar, J.; Higuero, A. M.; Abad-Rodriguez, J.

10.1101/2024.10.14.617868 — neuroscience — Posted on 2025-04-10

3495 Ribosome demand links transcriptional bursts to protein expression noise

Pal, S.; Ray, U.; Dhar, R.

10.1101/2023.10.19.563206 — systems biology — Posted on 2025-04-10

3496 Measurements of Contractility in Actin Convergence Zone and KIF11-Inhibited Mitotic Spindles

Matov, A.

10.1101/2024.06.28.601275 — cell biology — Posted on 2025-04-10

3497 Cerebellum-Targeted Transcranial Focused Ultrasound Stimulation Modulates Hippocampus Neural Activities

Liu, Y.; Cho, K. Y.; Hung, T. S.; Zhuo, C.; Lai, H. M.; Tin, C.

10.1101/2025.04.09.647932 — bioengineering — Posted on 2025-04-09

3498 ERK and PKA signaling drive the evolutionary expansion of the cortex

Zhang, Z.; Xu, Z.; Fu, T.; Li, J.; Yang, F.; Yang, C.; Zheng, W.; Sha, Z.; Gao, Y.; Sun, M.; Li, Z.; Ding, J.; LI, X.; Yang, Z.

10.1101/2025.04.09.647935 — developmental biology — Posted on 2025-04-09

3499 Epiproteomic control of the epitranscriptome drives cortical neurogenesis

10.1101/2025.04.09.646620 — cell biology — Posted on 2025-04-09

3500 Extracellular vesicles released from cortical neurons influence spontaneous activity of recipient neurons.

Lombino, F. L.; Shafiq, M.; Matamoros-Angles, A.; Schwarz, J. R.; Gromova, K. V.; Stajano, D.; Siebels, B.; Bergmann, L.; Magnus, T.; Schweizer, M.; Ricklefs, F. L.; Schlueter, H.; Hill, A. F.; Kneussel, M.; Glatzel, M.

10.1101/2025.04.09.647922 — neuroscience — Posted on 2025-04-09

3501 Learning and language in the unconscious human hippocampus

Katlowitz, K. A.; Shah, S.; Franch, M. C.; Adkinson, J.; Belanger, J. L.; Mathura, R. K.; meszena, D.; Mickiewicz, E. A.; McGinley, M.; Munoz, W.; Banks, G. P.; Cash, S. S.; Hsu, C.-W.; Paulk, A. C.; Provenza, N. R.; Watrous, A.; Williams, Z.; Heilbronner, S. R.; Kim, R.; Rungratsameetaweemana, N.; Hayden, B. Y.; Sheth, S. A.

10.1101/2025.04.09.648012 — neuroscience — Posted on 2025-04-09

3502 Reward influences movement vigor through multiple motor cortical mechanisms

Smoulder, A. L.; Marino, P. J.; Oby, E. R.; Snyder, S. E.; Batista, A. P.; Chase, S. M.

10.1101/2025.04.09.648001 — neuroscience — Posted on 2025-04-09

3503 Hypoimmunogenic hPSC-derived cardiac organoids for immune evasion and heart repair

Silver, S. E.; Howells, A. R.; Arhontoulis, D. C.; Randolph, L. N.; Hyams, N. A.; Barrs, R. W.; Li, M.; Kerr, C. M.; Robino, R. A.; Morningstar, J. E.; Bain, J. D.; Floy, M. E.; Norris, R. A.; Bao, X.; Ruddy, J. M.; Palecek, S. P.; Ferreira, L. M. R.; Lian, X. L.; Mei, Y.

10.1101/2025.04.09.648007 — bioengineering — Posted on 2025-04-09

3504 Predictive Ability of Enviromic Modeling in GxE Interactions for Upland Rice Site Recommendations

Bahia, M. A. M.; Marcatti, G. E.; Breseghello, F.; Melo, P. G. S.; Dias, K. O. G.; Xu, Y.; Resende, R. T.

10.1101/2025.04.05.647387 — genetics — Posted on 2025-04-09

3505 The coordinated regulatory roles of two LysR-Type Transcriptional Regulators balance chorismate and protocatechuate partition in Listeria organisms

Xue, K.; Hong, C. Y. K.; Kadriu, E.; Christendat, D.

10.1101/2025.04.08.647683 — molecular biology — Posted on 2025-04-09

3506 EPB41L4A-AS1 long noncoding RNA acts in both cis- and trans-acting transcriptional regulation and controls nucleolar biology

Monziani, A.; Unfried, J. P.; Cvetanovic, T.; Ulitsky, I.

10.1101/2025.04.08.647803 — molecular biology — Posted on 2025-04-09

3507 Single-cell phylogenomics identifies major groups of marine eugregarine parasites (Apicomplexa)

Park, E.; Na, I.; Closs, A.; Hall, K.; Froese, T.; Currie-Olsen, D.; Pontier, O.; Van Steenkiste, N.; Keeling, P. J.; Leander, B. S.

10.1101/2025.04.08.647885 — microbiology — Posted on 2025-04-09

3508 Activity-Dependent Remodeling of Corticostriatal Axonal Boutons During Motor Learning

Sheng, M.; Lu, D.; Sheng, K.; Ding, J.

10.1101/2024.06.10.598366 — neuroscience — Posted on 2025-04-09

3509 Mutations in ASH1L cause a neurodevelopmental disorder with sex differences in epilepsy and autism

Papendorp, C. M.; Nolan, E.; Higashimori, H.; Jhanji, M.; Goicouria, L.; Pieplow, C.; Whitley, K.; Defreitas, S.; Elacio, J.; Nie, D.; Kavanaugh, B.; Best, C. R.; Lizarraga, S. B.; Liu, J. S.-H.

10.1101/2025.02.21.639570 — neuroscience — Posted on 2025-04-09

3510 Intestinal fructose metabolism/GLP-1/β-cell axis counteracts hyperglycemia after short-term fructose ingestion

Murao, N.; Seino, Y.; Morikawa, R.; Hidaka, S.; Haraguchi, T.; Tomatsu, E.; Habara, M.; Ohno, T.; Yokoi, N.; Harada, N.; Hayashi, Y.; Yamada, Y.; Suzuki, A.

10.1101/2025.04.01.646509 — physiology — Posted on 2025-04-09

3511 An ALS Therapeutic Assembly Modulator Target in Peripheral Blood Mononuclear Cells: Implications for ALS Pathophysiology, Therapeutics, and Diagnostics

Yu, S.; Michon, M.; Lingappa, A. F.; Paulvannan, K.; Solas, D.; Staats, K. A.; Ichida, J.; Dey, D.; Rosenfeld, J.; Lingappa, V. R.

10.1101/2024.03.28.587289 — physiology — Posted on 2025-04-09

3512 Genomic profiling of active vitamin D colonic responses in African- and European-Americans identifies an ancestry-related regulatory variant of POLB

Kupfer, S.; Witonsky, D.; Laxman, B.; Usman, H.; Bielski, M.; Lawrence, K.

10.1101/2025.04.09.647365 — genomics — Posted on 2025-04-09

3513 The GSA Family in 2025: A Broadened Sharing Platform for Multi-Omics and Multimodal Data

Zhang, S.; Chen, X.; Jin, E.; Wang, A.; Chen, T.; Zhang, X.; Zhu, J.; Dong, L.; Sun, Y.; Yu, C.; Zhou, Y.; Fan, Z.; Chen, H.; Zhai, S.; Sun, Y.; Chen, Q.; Xiao, J.; Song, S.; Zhang, Z.; Bao, Y.; Wang, Y.; Zhao, W.

10.1101/2025.03.31.646270 — genomics — Posted on 2025-04-09

3514 Capturing Natural Evolution in Function-guided RNA Design via Genomic Foundation Models

Zheng, S.; Huang, Y.; Zhang, B.; Chen, X. J.; Ma, R.; Zhang, Z.; Chen, X.; Yang, Y.

10.1101/2025.04.08.647793 — evolutionary biology — Posted on 2025-04-09

3515 Enhancement of Prednisolone efficacy and safety in Duchenne muscular dystrophy via neutrophil elastase inhibition

Johnson, K. A.; Jones, F. K.; Ghadiali, R. S.; Lee, G.; Luke, T.-H. A.; Sweeney, M. D.; Moffitt, R. A.; Mamchaoui, K.; Ricci, E.; Young, I.; Pisconti, A.

10.1101/2025.02.26.640472 — cell biology — Posted on 2025-04-09

3516 Lock, Protect, and Bind: In Vitro Selection of LNA-modified Aptamers Using a Mutant T7 RNA Polymerase

Neis, K.; Civit, L.; Pedersen, K.; Schachtner, M.; Wengel, J.; Wagner, R.; Thiel, S.; Kjems, J.; Valero, J.

10.1101/2025.04.09.647959 — molecular biology — Posted on 2025-04-09

3517 Reduction of Listeria on stainless steel surfaces is impacted by sanitizer application method

Jiao, Y.; Baker, J.; Slaughter, C.; Daeschel, D.; Snyder, A. B.

10.1101/2025.04.09.647964 — microbiology — Posted on 2025-04-09

3518 Elucidating Compound Mechanism of Action and Polypharmacology with a Large-scale Perturbational Profile Compendium

Hu, L. Z.; Hirschhorn, T.; Douglass, E.; Murray, D.; Trudeau, S. J.; Turunen, M.; Pampou, S.; Grunn, A.; Realubit, R.; Antolin, A. A.; Wang, A. L. E.; Li, H.; Subramaniam, P.; Karan, C.; Alvarez, M.; Honig, B.; Stockwell, B. R.; Califano, A.

10.1101/2023.10.08.561457 — systems biology — Posted on 2025-04-09

3519 Specialized Pro-Resolving Mediator loaded Extracellular Vesicles Mitigate Pulmonary Inflammation

Karpurapu, M.; Yan, J.; Chung, S.; PANNU, S.; Parinandi, N.; Zhang, L.; Berdyshev, E.; Christman, J. W.

10.1101/2025.04.09.648009 — synthetic biology — Posted on 2025-04-09

3520 Nanoscale domains govern local diffusion and aging within FUS condensates

Gao, G.; Sumrall, E. R.; Walter, N. G.

10.1101/2024.04.01.587651 — biophysics — Posted on 2025-04-09

3521 Base Editing Rescue of Seizures and SUDEP in SCN8A Developmental Epileptic Encephalopathy

Reever, C. M.; Boscia, A. R.; Deutsch, T. C. J.; Patel, M. P.; Miralles, R. M.; Kittur, S.; Fleischel, E. J.; Buo, A. M. L.; Yorek, M. S.; Meisler, M. H.; Farber, C. R.; Patel, M. K.

10.1101/2025.04.09.647983 — bioengineering — Posted on 2025-04-09

3522 Structural basis of multitasking by the apicoplast DNA polymerase from Plasmodium falciparum

Kumari, A.; Enache, T.; Craggs, T. D.; Pata, J. D.; Lahiri, I.

10.1101/2025.04.09.647933 — biochemistry — Posted on 2025-04-09

3523 Long-Distance Trail Running Induces Inflammatory-Associated Protein, Lipid, and Purine Oxidation in Red Blood Cells

Nemkov, T.; Stauffer, E.; Cendali, F.; Stephenson, D.; Nader, E.; Robert, M.; Skinner, S.; Dzieciatkowska, M.; Hansen, K. C.; Robach, P.; Millet, G.; Connes, P.; D'Alessandro, A.

10.1101/2025.04.09.648006 — biochemistry — Posted on 2025-04-09

3524 Caspase Cleavage of Kaposi Sarcoma-Associated Herpesvirus Proteins: A role for K5 in Preventing Caspase-Mediated Cell Death during Lytic Replication

Astter, Y.; Davis, D.; Treco, E.; Shrestha, P.; Stream, A.; Haque, M.; Mulugeta, N.; Yarchoan, R.

10.1101/2025.04.08.647834 — biochemistry — Posted on 2025-04-09

3525 Characterization of the Mechanisms Underlying Sulfasalazine-Induced Ferroptotic Cell Death: Role of Protein Disulfide Isomerase-Mediated NOS Activation and NO Accumulation

Jia, Y.-C.; Zhong, J.-L.; Hao, X.; Zhu, B. T.

10.1101/2025.04.03.647136 — biochemistry — Posted on 2025-04-09

3526 Population structure and genetic diversity of the Critically Endangered bowmouth guitarfish (Rhina ancylostomus) in the Northwest Indian Ocean

Kipperman, M. J.; Jabado, R. W.; Haque, A. B.; Fernando, D.; Anjani, P. A. D. L.; Spaet, J. L.; Humble, E.

10.1101/2024.03.15.585225 — evolutionary biology — Posted on 2025-04-09

3527 Evolution of species' range and niche in changing environments

Polechova, J.

10.1101/2025.01.16.633367 — evolutionary biology — Posted on 2025-04-09

3528 The Chromosome 19 miRNA Cluster Guards Trophoblasts Against Overacting Innate Immunity

Mouillet, J.-F.; Ouyang, Y.; Sadovsky, E.; Kothandan, V. K.; Sorenson, H. L.; Badeau, L. J.; Sarkar, S. N.; Chu, T.; Sorkin, A.; Sadovsky, Y.

10.1101/2025.04.03.647038 — developmental biology — Posted on 2025-04-09

3529 Improved specificity and efficiency of in vivo adenine base editing therapies with hybrid guide RNAs

Whittaker, M. N.; Brooks, D. L.; Quigley, A.; Jindal, I.; Said, H.; Qu, P.; Wang, J. Z.; Levine, M. A.; Ahrens-Nicklas, R. C.; Musunuru, K.; Alameh, M.-G.; Peranteau, W. H.; Wang, X.

10.1101/2024.04.22.590531 — molecular biology — Posted on 2025-04-09

3530 Insights into the Biocontrol Mechanisms of a Paenibacilluspeoriae Strain on Maize Seedling Blight through Multi-Omics Analysis

Hu, Y.; Chen, Y.; Chao, S.; Zhang, Y.; Song, L.; Wang, H.; Hu, Y.; Lü, B.

10.1101/2025.04.08.647891 — microbiology — Posted on 2025-04-09

3531 Context-dependent evolutionary dynamics toward bacterial survival during sequential antibiotic treatment

Lyon, A.; Yildiz, M. S.; Toprak, E.

10.1101/2025.04.08.647880 — microbiology — Posted on 2025-04-09

3532 Atypical phosphatases drive dissolved organic phosphorus utilization by phosphorus-stressed phytoplankton in the California Current Ecosystem

Steck, V.; Lampe, R. H.; Bhakta, S.; Marrufo, K. C.; Adams, J. C.; Sachdev, E.; Allen, A. E.; Diaz, J. M.

10.1101/2025.04.09.648040 — microbiology — Posted on 2025-04-09

3533 Versatile entomopathogenic activity of Purpureocillium takamizusanense against diverse agricultural pests

Lo, P.-H.; Abdrabo, K. A. E.-S.; Nai, Y.-S.; Lu, H.-l.; Huang, Y.-T.

10.1101/2025.04.08.647886 — microbiology — Posted on 2025-04-09

3534 Segmented filamentous bacteria undergo a structural transition at their adhesive tip during unicellular to filament development

Cruz, A. R.; Wimmer, B. H.; Teo, T.-H.; Pehau-Arnaudet, G.; Winter, J.-M.; Gazi, A.; Lafaye, P.; Brier, S.; Legrand, A.; Dubrovsky-Gaupp, A.; Berard, M.; Ayme, G.; Sartori-Rupp, A.; Medalia, O.; Schnupf, P.

10.1101/2025.04.09.647586 — microbiology — Posted on 2025-04-09

3535 Bactofilins are essential spatial organizers of peptidoglycan insertion in the Lyme disease spirochete Borrelia burgdorferi

Zinck, C. B.; Carracoi, V.; Kloos, Z. A.; Wachter, J.; Schwartz, C.; Stewart, P. E.; Jacobs-Wagner, C.; Rosa, P. A.; Takacs, C. N.

10.1101/2025.04.09.647816 — microbiology — Posted on 2025-04-09

3536 Caffeine induces age-dependent increases in brain complexity and criticality during sleep

Thölke, P.; Arcand-Lavigne, M.; Lajnef, T.; Frenette, S.; Carrier, J.; Jerbi, K.

10.1101/2024.05.27.596056 — neuroscience — Posted on 2025-04-09

3537 The extent of gender and race/ethnicity imbalance in infectious disease dynamics research

Taube, J. C.; Merritt, A.; Bansal, S.

10.1101/2024.12.19.629420 — scientific communication and education — Posted on 2025-04-09

3538 TTLL4 glutamyltransferase is a therapeutic target for NPM1-mutated acute myeloid leukemia

Schurer, A.; Ilyas, H.; Maron, M. I.; Hegde, S.; Leyden, M. R.; Roy, I.; Hyka, R.; Dada, L.; Shabanowitz, J.; Hunt, D.; Angeles, E.; Morell, V.; Lorton, B. M.; Glushakow-Smith, S.; Borger, D. K.; Wang, Y.; Miles, L. A.; Belizaire, R.; Kitamura, S.; Gritsman, K.; Shechter, D.

10.1101/2025.04.07.647605 — cancer biology — Posted on 2025-04-09

3539 Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence

Piyadasa, H.; Oberlton, B.; Ribi, M.; Ranek, J. S.; Averbukh, I.; Leow, K.; Amouzgar, M.; Liu, C. C.; Greenwald, N. F.; McCaffrey, E. F.; Kumar, R.; Ferrian, S.; Tsai, A. G.; Filiz, F.; Fullaway, C. C.; Bosse, M.; Varra, S. R.; Kong, A.; Sowers, C.; Gephart, M. H.; Nunez-Perez, P.; Yang, E.; Travers, M.; Schachter, M. J.; Liang, S.; Santi, M. R.; Bucktrout, S.; Gherardini, P. F.; Connolly, J.; Cole, K.; Barish, M. E.; Brown, C. E.; Oldridge, D. A.; Drake, R. R.; Phillips, J. J.; Okada, H.; Prins, R.; Bendall, S. C.; Angelo, M.

10.1101/2025.03.12.642624 — cancer biology — Posted on 2025-04-09

3540 OpDetect: A convolutional and recurrent neural network classifier for precise and sensitive operon detection from RNA-seq data

Karaji, R.; Pena-Castillo, L.

10.1101/2025.03.24.645056 — bioinformatics — Posted on 2025-04-09

3541 Bayesian automatic screening of pneumoniaand lung lesions localization from CT scans. Acombined method toward a more user-centredand explainable approach

Moure Prado, A.; Guerrero-Lopez, A.; Arias-Londono, J. D.; Godino-Llorente, J. I.

10.1101/2025.04.08.647710 — bioengineering — Posted on 2025-04-09

3542 MonoAlg3D: Enabling Cardiac Electrophysiology Digital Twins with an Efficient Open Source Scalable Solver on GPU Clusters

Berg, L. A.; Oliveira, R. S.; Camps, J.; Wang, Z. J.; Doste, R.; Bueno-Orovio, A.; dos Santos, R. W.; Rodriguez, B.

10.1101/2025.04.09.647733 — bioengineering — Posted on 2025-04-09

3543 Deltex and RING-UIM E3 ligases cooperate to create a ubiquitin-ADP-ribose hybrid mark on tankyrase, promoting its stabilization

Perrard, J.; Gao, K.; Ring, K.; Smith, S.

10.1101/2025.04.09.648013 — biochemistry — Posted on 2025-04-09

3544 PICRUSt2-SC: an update to the reference database used for functional prediction within PICRUSt2

Wright, R. J.; Langille, M. G.

10.1101/2025.01.27.635123 — genomics — Posted on 2025-04-09

3545 HIF1A contributes to the survival of aneuploid and mosaic pre-implantation embryos

Sanchez-Vasquez, E.; Bronner, M.; Zernicka-Goetz, M.

10.1101/2023.09.04.556218 — developmental biology — Posted on 2025-04-09

3546 Glial betaPix is essential for blood vessel integrity in the zebrafish brain

Chiu, S.; Zhou, Q.; Xiao, C.; Bai, L.; Zhu, X.; Ding, W.; Xiong, J.-W.

10.1101/2025.04.08.647738 — developmental biology — Posted on 2025-04-09

3547 Hyperactive 20S Proteasome Enhances Proteostasis and ERAD in C. elegans via degradation of Intrinsically Disordered Proteins.

Salcedo-Tacuma, D.; Asad, N.; Howells, G.; Anderson, R.; Smith, D. M.

10.1101/2024.04.04.588128 — cell biology — Posted on 2025-04-09

3548 Elucidating Chiral Myosin-Induced Actin Dynamics: From Single Filament Behavior to Collective Structures

Haraguchi, T.; Yoshimura, K.; Inoue, Y.; Imi, T.; Hasegawa, K.; Nagai, T.; Mori, T.; Matsuno, K.; Ito, K.

10.1101/2025.03.26.645581 — cell biology — Posted on 2025-04-09

3549 Dual GLP-1 and GIP receptor agonist Tirzapetide plays an off-target role in the modulation of the β-adrenoceptors and glucose metabolism in hyperglycemic or senescent cardiac cells

Aydos, D.; Aksoy, Z. B.; Unal, M. A.; Akcali, K. C.; Bitirim, C. V.; Turan, B.

10.1101/2025.04.09.648025 — molecular biology — Posted on 2025-04-09

3550 HSF1 Activator Azadiradione Ameliorates Parkinson Disease and Extends Lifespan in Preclinical Models: Analysis of Underlying Molecular Mechanism

Pal, M.; SARENG, H. R.; Dutta, N.; GHOSH, S.; Chowdhury, U.; Nelson, V. K.; Mandal, S. C.; Mandal, A. K.; Prasad, M.

10.1101/2025.04.09.647992 — molecular biology — Posted on 2025-04-09

3551 Complementary killing activities of Pbunavirus LS1 and Bruynoghevirus LUZ24 phages on planktonic and sessile Pseudomonas aeruginosa PAO1 derivatives

Billaud, M.; Plantady, C.; Lerouge, B.; Ollivier, E.; Lossouarn, J.; Moncaut, E.; Deschamps, J.; Briandet, R.; Cleret, A.; Fevre, C.; Demarre, G.; Petit, M.-A.

10.1101/2025.04.09.647956 — microbiology — Posted on 2025-04-09

3552 Enhanced Activity of Apramycin and Apramycin-Based Combinations Against Mycobacteroides abscessus

Huang, Y.; Trueslon, K. A.; Stuart, I. A.; O'Doherty, G. A.; Kirby, J. E.

10.1101/2025.04.09.648020 — microbiology — Posted on 2025-04-09

3553 Subpopulations in clinical samples of M. tuberculosis can give rise to rifampicin resistance and shed light on how resistance is acquired

Brunner, V. M.; Fowler, P. W.

10.1101/2025.04.09.647945 — microbiology — Posted on 2025-04-09

3554 Identification of Novel Mutations Causing Clofazimine Resistance in Mycobacterium intracellulare

Jiang, X.; Cao, D.; Dong, X.; Xu, P.; Li, Y.; Yuan, X.; Xiang, Y.; Xu, K.; Zhang, Y.

10.1101/2025.04.09.647911 — microbiology — Posted on 2025-04-09

3555 Mutations differentially affecting the coronavirus Mac1 ADP-ribose binding and hydrolysis activities indicate that it promotes multiple stages of the viral replication cycle

O Connor, J.; Roy, A.; Khattabi, R.; Kerr, C. M.; Schwarting, N.; Alhammad, Y. M.; Gao, P.; Zhang, X.; Deng, X.; Fehr, A. R.

10.1101/2025.04.08.647734 — microbiology — Posted on 2025-04-09

3556 GSK-3 regulates CD4-CD8 cooperation needed to generate super-armed CD8+ cytolytic T cells against tumors

Moes, B.; Janna, J.; Kazanova, A.; LIU, C.; Gao, Y.; Ponnoor, N. A.; Castoun-Puckett, L.; Oroya, A.; Nguyen, H. L.; Cabald, A. L.; Tu, T. H.; Rudd, C. E.

10.1101/2025.03.08.642085 — immunology — Posted on 2025-04-09

3557 Association between Brain Morphometry and Cognitive Function during Adolescence: Insights from a Comprehensive Large-Scale Analysis from 9 to 15 Years Old

Yan, J.; Iturria-Medina, Y.; Bezgin, G.; Toussaint, P. J.; Hilger, K.; Genc, E.; Evans, A.; Karama, S.

10.1101/2024.06.18.599653 — neuroscience — Posted on 2025-04-09

3558 FRAZZLED/DCC REGULATES GAP JUNCTION FORMATION AT A DROSOPHILA GIANT SYNAPSE THROUGH TRANSCRIPTION

Lopez, J.; Boerner, J.; Robbins, K.; Pena, R.; Murphey, R.

10.1101/2025.04.08.647628 — neuroscience — Posted on 2025-04-09

3559 Monkey See, Model Knew: Large Language Models Accurately Predict Visual Brain Responses in Humans AND Non-Human Primates

Conwell, C.; McMahon, E.; Jagadeesh, A.; Vinken, K.; Sharma, S.; Prince, J. S.; Alvarez, G.; Konkle, T.; Livignstone, M.; Isik, L.

10.1101/2025.03.05.641284 — neuroscience — Posted on 2025-04-09

3560 Transient, early, female-specific increase in cortical glial fibrillary acidic protein distribution in the Syrian hamster model of mild peripheral COVID-19

Rahmani Manesh, M.; Wicki-Stordeur, L. E.; York, N. S.; Vendramelli, R.; Warner, B.; Vecchiarelli, H. A.; Ranier-Pope, L.; Khakpour, M.; Bennouna, L. R.; Tremblay, M.-E.; Kobasa, D.; Swayne, L. A.

10.1101/2025.04.08.647811 — neuroscience — Posted on 2025-04-09

3561 Past and present caregiving experiencesimpact prefrontal connectivity and recall for attachment-schema narratives

Lee, C. S.; Cohen, S. S.; Hutchinson, S.; Tottenham, N.; Baldassano, C.

10.1101/2024.09.13.612953 — neuroscience — Posted on 2025-04-09

3562 Auditory Brainstem Responses in Two Closely Related Peromyscus Species (Peromyscus leucopus and Peromyscus maniculatus)

Joseph, L.; New, E. M.; Joseph, D. M.; Woodley, T. C.; Franco, V. Y.; Li, B.-Z.; Wogan, G. O.; McCullagh, E. A.

10.1101/2024.12.09.627419 — neuroscience — Posted on 2025-04-09

3563 The precision of hippocampal representations predicts incremental value-learning across the adult lifespan

vanGeen, C.; Lempert, K. M.; Cohen, M.; MacNear, K. A.; Reckers, F. M.; Zaneski, L.; Wolk, D.; Kable, J. W.

10.1101/2025.04.08.647815 — neuroscience — Posted on 2025-04-09

3564 Level of host concealment shape parasitoid community of microlepidopteran species living on hops

Hovorka, T.; Holy, K.; Vasilita, C.; Krogmann, L.; Jansta, P.

10.1101/2025.04.06.647420 — zoology — Posted on 2025-04-09

3565 RAPID-DASH: Single-Day Assembly of Guide RNA Arrays for Multiplexed CRISPR-Cas9 Applications

Salaudeen, A. L.; Mateyko, N.; de Boer, C. G.

10.1101/2025.04.09.648054 — synthetic biology — Posted on 2025-04-09

3566 Probing the effect of PEG-DNA interactions and buffer viscosity on tethered DNA in shear flow

Zohra, F. T.; Al-Zuhairi, H.; Reinoza, J.; Kim, H.; Hanke, A.

10.1101/2025.04.05.647409 — biophysics — Posted on 2025-04-09

3567 How Nasal Cavity Structure Influences Empty Nose Syndrome Severity: A CFD-Based Analysis

RUMIANO, A.; Dinh, T.

10.1101/2025.04.04.645990 — biophysics — Posted on 2025-04-09

3568 Helicon: Helical indexing and 3D reconstruction from one image

Li, D.; Zhang, X.; Jiang, W.

10.1101/2025.04.05.647385 — biophysics — Posted on 2025-04-09

3569 NEAR: Neural Embeddings for Amino acid Relationships

Olson, D. R.; Colligan, T.; Demekas, D.; Roddy, J. W.; Youens-Clark, K.; Wheeler, T.

10.1101/2024.01.25.577287 — bioinformatics — Posted on 2025-04-09

3570 WIMOAD: Weighted Integration of Multi-Omics Data with Meta Learning for Alzheimer's Disease Diagnosis

Xiao, H.; Wang, J.; Wan, S.

10.1101/2024.09.25.614862 — bioinformatics — Posted on 2025-04-09

3571 Individuality transfer: Predicting human decision-making across tasks

Higashi, H.

10.1101/2025.03.25.645375 — animal behavior and cognition — Posted on 2025-04-09

3572 Chromosome-level phased genome assembly of the Argan tree Sideroxylon spinosum L.

Mateus, I. B.; Essahibi, A.; Nicholson, P.; Hijri, M.; Qaddoury, A.; Falquet, L.; Reinhardt, D.

10.1101/2025.04.06.647421 — genomics — Posted on 2025-04-09

3573 CellCover Defines Marker Gene Panels Capturing Developmental Progression in Neocortical Neural Stem Cell Identity

Ji, L.; Wang, A.; Sonthalia, S.; Seo, S.; Naiman, D. Q.; Younes, L.; Colantuoni, C.; Geman, D.

10.1101/2023.04.06.535943 — genomics — Posted on 2025-04-09

3574 Low-dimensional genotype-fitness mapping across divergent environments suggests a limiting functions model of fitness

Ghosh, O. M.; Kinsler, G.; Good, B. H.; Petrov, D.

10.1101/2025.04.05.647371 — evolutionary biology — Posted on 2025-04-09

3575 Extraordinary adaptations: Functional and evolutionary synergy of trait components can explain the existence of leaf masquerade

Wainwright, J. B.; Rolfe, C. E. J.; Ruxton, G. D.; Bailey, N. W.

10.1101/2025.04.05.647375 — evolutionary biology — Posted on 2025-04-09

3576 Multiple evolutionary events in host plant adaptation in Lepidoptera

Luo, M.; Li, B.; Ma, L.; Jia, Z.; Shi, Z.; Liu, H.; Wang, Z.; Zhang, B.; Yu, S.; Qi, J.; Xiao, Y.; Zhou, S.; Chung, H.; Wang, G.

10.1101/2025.04.05.647383 — evolutionary biology — Posted on 2025-04-09

3577 Scales of marine endemism in oceanic islands and the Provincial-Island endemism

Pinheiro, H. T.; Rocha, L. A.; Quimbayo, J. P.

10.1101/2024.07.12.603346 — ecology — Posted on 2025-04-09

3578 A Multi-Valued Logic Model of T Cell Activation and Cytokine Response

Tozzi, A.

10.1101/2025.04.05.647356 — immunology — Posted on 2025-04-09

3579 Beta Adrenergic Signaling as a Therapeutic Target for Autoimmunity

Lauten, T. H.; Reed, E. C.; Natour, T.; Pitts, L. J.; Jojo, C. N.; Griffin, B. L.; Case, A. J.

10.1101/2025.04.05.647384 — immunology — Posted on 2025-04-09

3580 Regulation of B cell tolerance and autoimmunity by miR-130b

Herrero-Fernandez, B.; Gonzalez-Molina, M. d. P.; Gamez-Reche, L.; Prieto-Munoz, A. M.; Sanz, J.; Gonzalo, T.; Moreno, A.; Lopez-Molina, M.; Manas, L.; Nemazee, D.; Xiao, C.; Otero-Ortega, L.; Gonzalez-Martin, A.

10.1101/2025.01.22.634242 — immunology — Posted on 2025-04-09

3581 The osteoarthritis associated sphingolipid sphingomyelin 34:1 causes inflammatory pain in mice

Rickman, R. H.; Pattison, L. A.; Qiu, L.; Dannawi, M.; Welsh, F.; Smith, E. S. J.

10.1101/2024.11.19.621807 — neuroscience — Posted on 2025-04-09

3582 INHBA promotes the progression of gastric cancer by activating MAPK signaling pathway via targeting ITGA6

Zhou, G.; Zhang, R.; Nie, L.; Si, Y.; Liu, T.; Jing, W.; Han, S.; Xuan, M.; Yu, W.; Wang, J.

10.1101/2025.04.05.647266 — cancer biology — Posted on 2025-04-09

3583 Optimizing automated detection for cytoplasmic TDP25 aggre-gates in fluorescence imaging

Sogawa, S.; Sasaki, K.; Kitamura, A.

10.1101/2025.04.04.647339 — biophysics — Posted on 2025-04-09

3584 In Silico Characterization of a Hypothetical Protein from Pseudomonas aeruginosa LESB58: A Structural and Functional Perspective.

Hossain, S.; jannat, A.

10.1101/2025.04.06.647430 — bioinformatics — Posted on 2025-04-09

3585 Domain shifts in infant brain diffusion MRI: Quantification and mitigation for fODF estimation

Lin, R.; Kebiri, H.; Gholipour, A.; Chen, Y.; Thiran, J.-P.; Karimi, D.; Bach Cuadra, M.

10.1101/2025.04.04.647303 — bioinformatics — Posted on 2025-04-09

3586 Diversity of diazotrophs in the Northern Pacific Ocean and sensitivity of the symbiotic unicellular cyanobacteria (UCYN-A) to inorganic nitrogen availability

Reed, G. M.

10.1101/2025.04.05.647397 — bioinformatics — Posted on 2025-04-09

3587 Spatial Metagene Discovery and Associated Molecular Pattern Characterization in Spatial Transcriptomics and Multi-Omics using SEPAR

Zhang, L.; Zhu, Y.; Zhang, S.

10.1101/2025.04.05.647412 — bioinformatics — Posted on 2025-04-09

3588 In Silico Evaluation and Therapeutic Targeting of LVDD9B Protein for WSSV Inhibition: Molecular and Ecological Insights for Aquaculture Solutions

Iftehimul, M.; Hasan, N. A.; Akter, M. F.; Hossain, M. A.; Tima, S. A.; Kabir, A.; Choudhury, P.; Bhowmick, A.; Pranto, S. A.; Hasan, A. M. W.; Ansari, S. A.; Rahman, M. H.

10.1101/2025.04.05.647344 — bioinformatics — Posted on 2025-04-09

3589 A High-Precision Timing Method and Digital Interface for Closed-Loop TMS

Kahilakoski, O.-P.; Sinisalo, H.; Nieminen, J. O.; Alkio, K.; Valen, K.; Kozak, G.; Ilmoniemi, R. J.; Roine, T.

10.1101/2025.04.05.647340 — bioengineering — Posted on 2025-04-09

3590 NeuroSimo: an open-source software for closed-loop EEG- or EMG-guided TMS

Kahilakoski, O.-P.; Alkio, K.; Siljamo, O.; Valen, K.; Laurinoja, J.; Haxel, L.; Makkonen, M.; Mutanen, T. P.; Tommila, T.; Guidotti, R.; Pieramico, G.; Ilmoniemi, R. J.; Roine, T.

10.1101/2025.04.05.647342 — bioengineering — Posted on 2025-04-09

3591 Mucosal tissue NK cells tune their function between optimal anti-pathogen activity and tissue protection

Vick, S. C.; Domenjo-Vila, E.; Frutoso, M.; Glabman, R. A.; Warrier, L. S.; Hughes, S. M.; Kirby, A. C.; Fialkow, M. F.; Hladik, F.; Prlic, M.; Lund, J. M.

10.1101/2025.04.04.647286 — immunology — Posted on 2025-04-09

3592 Refined cell transfer model reveals roles for Ascl2 and Cxcr3 in splenic localization of mouse NK cells during virus infection

Canaday, L. M.; Cox, A.; Feldman, H. A.; Seelamneni, H.; Ali, A.; Tuazon, J.; Calderon, L. B.; Bennett, S.; Yan, A.; Wilson, M.; Velu, V.; Waggoner, S. N.

10.1101/2025.04.05.647391 — immunology — Posted on 2025-04-09

3593 Tumor-Initiating Cells Fine-tune the Plasticity of Neutrophils to Sculpt a Protective Niche

Guo, W.; Luan, J.; Huang, X.; Leon, D.; Good, J.; Nicholson, B.; Izumchenko, E.; Rosenberg, A. J.; Agrawal, N.; Bertacchi, B.; Bolotin, D.; Gunzer, M.; Ballesteros, I.; Hidalgo, A.; Miao, Y. P.

10.1101/2025.04.04.647324 — cancer biology — Posted on 2025-04-09

3594 Optimizing in utero electroporation of the developing mouse pons to model diffuse midline glioma

Mason, M. S.; Morales Murillo, H.; Dudek, M. G.; Maher, S. E.; Franco, S. J.

10.1101/2025.04.06.647423 — cancer biology — Posted on 2025-04-09

3595 Magnetic Field-dependent Isotope Effect Supports Radical Pair Mechanism in Tubulin Polymerization

ZADEH-HAGHIGHI, H.; Siguenza, C. R.; Smith, R. P.; Simon, C.; Craddock, T. J. A.

10.1101/2025.04.04.647325 — biophysics — Posted on 2025-04-09

3596 A methodology to reduce the localization error in multi-loci microscopy provides new insights into enhancer biology

Bohrer, C. H.; Larson, D. R.

10.1101/2025.04.05.647393 — biophysics — Posted on 2025-04-09

3597 Quantifying Uncertainty in Phasor-Based Time-Domain Fluorescence Lifetime Imaging Microscopy

Chen, Q.; Park, J.; Mu, S.; Gao, L.

10.1101/2025.04.04.647302 — bioinformatics — Posted on 2025-04-09

3598 Toward Predictive Modeling of Microneedle Design: Establishing a Correlation Between CAD Models, 3D Printed Arrays, and PDMS Molds

Tiwari, V. K.; Tabassum, S.

10.1101/2025.04.05.647392 — bioengineering — Posted on 2025-04-09

3599 Solid tumor CAR T cells engineered with fusion proteins targeting PDL1 for localized IL-12 delivery

Murad, J. P.; Christian, L.; Rosa, R.; Ren, Y.; Lee, E.; Lopez, L.; Park, A.; Yang, J.; Trac, C.; Adkins, L.; Chang, W.-C.; Martinez, C.; June, C. H.; Forman, S.; Ishihara, J.; Lee, J. K.; Stern, L.; Priceman, S. J.

10.1101/2025.04.04.647304 — bioengineering — Posted on 2025-04-09

3600 Cooperative effects in DNA-functionalized polymeric nanoparticles

Gaki, P.; Klymchenko, A. S.

10.1101/2025.04.06.647366 — bioengineering — Posted on 2025-04-09

3601 Escherichia coli transforms the leucyl-tRNA synthetase gene in vivo into primordial genes

Tang, G. Q.; Carter, C. W.

10.1101/2025.04.05.647346 — evolutionary biology — Posted on 2025-04-09

3602 Development of circulating cell-free DNA reduced representation bisulfite sequencing for clinical methylomics diagnostics

De Koker, A.; Raman, L.; Van Paemel, R.; Van der Linden, M.; Van de Velde, S.; Van der Leest, P.; Van Gaever, B.; Zaka, A.; Vermaelen, K.; Demedts, I.; Surmont, V.; Himpe, U.; Dedeurwaerdere, F.; Ferdinande, L.; Claes, K.; De Wilde, J.; Timens, W.; De Jager, V.; Hiltermann, J.; De Wilde, B.; Menten, B.; De Preter, K.; Schuuring, E.; Van Dorpe, J.; Callewaert, N.

10.1101/663195 — genomics — Posted on 2025-04-09

3603 Plasmid carriage and the unorthodox use of fitness in microbiology

Reding, C.

10.1101/810259 — evolutionary biology — Posted on 2025-04-09

3604 A subset of Haematopoietic Stem Cells resists Plasmodium infection-induced stress by uncoupling interferon sensing and metabolic activation

Georgiou, C.; Liu, Q.; Anton, S. G.; Bruno, F.; Birch, F.; Kinston, S.; Chabra, S.; Wilson, N.; Pospori, C.; Blagborough, A. M.; Gottgens, B.; Luis, T.; Lo Celso, C. L.

10.1101/2025.04.09.647965 — cell biology — Posted on 2025-04-09

3605 Comparative study of Anopheles gambiae larval habitats and larval densities in relation to physicochemical parameters in three urban sites in Abidjan district.

Kacou, K. Y. A.; Yokoly, N. F.; Le Bissonnais, S.; Zahouli, B. Z. J.; Jackson IK Kouame, J. K. I.; Tia, B. J.-P.; Koudou, G. B.

10.1101/2025.04.05.647363 — ecology — Posted on 2025-04-09

3606 A multi-institutional investigation of psilocybin's effects on mouse behavior

Lu, O. D.; White, K.; Raymond, K.; Liu, C.; Klein, A. S.; Green, N.; Vaillancourt, S.; Gallagher, A.; Shindy, L.; Li, A.; Li, R.; Zou, M.; Wallquist, K.; Casey, A. B.; Cameron, L. P.; Pomrenze, M. B.; Sohal, V.; Kheirbek, M. A.; Gomez, A. M.; Lammel, S.; Heifets, B. D.; Malenka, R. C.

10.1101/2025.04.08.647810 — neuroscience — Posted on 2025-04-09

3607 Structural Basis for Negative Regulation of ABA Signaling by ROP11 GTPase

Zhao, C.; Nadeem, H.; Shukla, D.

10.1101/2020.05.20.107185 — plant biology — Posted on 2025-04-09

3608 SpaceBF: Spatial coexpression analysis using Bayesian Fused approaches in spatial omics datasets

Seal, S.; Neelon, B.

10.1101/2025.03.29.646124 — bioinformatics — Posted on 2025-04-09

3609 Adeno-associated viruses escort nanomaterials to specific cells and tissues

Nagao, K.; Vargas Paniagua, E.; Lei, K.; Beckham, J. L.; Worthington, P.; Manthey, M.; Ye, M.; Koehler, F.; Kim, Y. J.; Malkin, E.; Onoda, M.; Kent, N.; Michida, S.; Crespin Guerra, E.; Macfarlane, R. J.; Anikeeva, P.

10.1101/2025.04.04.647267 — bioengineering — Posted on 2025-04-09

3610 EPB41L4A-AS1 long noncoding RNA acts in both cis- and trans-acting transcriptional regulation and controls nucleolar biology

Monziani, A.; Unfried, J. P.; Cvetanovic, T.; Ulitsky, I.

10.1101/2025.04.08.647803 — molecular biology — Posted on 2025-04-09

3611 High-integrity nanoemulsions formulation of resiquimod (R848) enhances stability and delivery for triple negative breast cancer immunotherapy

Salem, A.; Attia, S.; El-Ghlban, S.; Montaser, A. S.; Abdelhameed, M. F.; Helmy, M. W.; Attia, M. F.

10.1101/2025.04.04.647265 — immunology — Posted on 2025-04-09

3612 T cell epitope mapping reveals immunodominance of evolutionarily conserved regions within SARS-CoV-2 proteome.

Bozkus, C. C.; Brown, M.; Velazquez, L.; Thomas, M.; Wilson, E. A.; O'Donnell, T.; Ruchnewitz, D.; Geertz, D.; Bykov, Y.; Kodysh, J.; Oguntuyo, K. Y.; Roudko, V.; Hoyos, D.; Srivastava, K.; Kleiner, G.; Alshammary, H.; Karekar, N.; McClain, C.; Gopal, R.; Nie, K.; Del Valle, D.; Delbeau-Zagelbaum, D.; Rodriguez, D.; Setal, J.; The Mount Sinai COVID-19 Biobank Team, ; Carroll, E.; Wiesendanger, M.; Gulko, P.; Charney, A.; Merad, M.; Kim-Schulze, S.; Lee, B.; Wajnberg, A.; Simon, V.; Greenbaum, B. D.; Chowell, D.; Vabret, N.; Luksza, M.; Bhardwaj, N.

10.1101/2024.10.23.619918 — immunology — Posted on 2025-04-09

3613 Glutamatergic and GABAergic synapses in the human spinal dorsal horn revealed with immunohistochemistry

Davis, O. C.; Todd, A.; Price, T. J.

10.1101/2025.04.07.647666 — neuroscience — Posted on 2025-04-09

3614 FRAZZLED/DCC REGULATES GAP JUNCTION FORMATION AT A DROSOPHILA GIANT SYNAPSE THROUGH TRANSCRIPTION

Lopez, J.; Murphey, R.; Pena, R.; Boerner, J.; Robbins, K.

10.1101/2025.04.08.647628 — neuroscience — Posted on 2025-04-09

3615 Drosophila Modeling Identifies Increased Sleep as a Link Between Insomnia and Cardiovascular Disease

Mandigo, T. R.; Abou Daya, F.; Patel, D.; Math, S. R.; Ober, L.; Maher, M.; Melkani, G. C.; Walker, J. A.; Saxena, R.

10.1101/2025.04.07.647668 — neuroscience — Posted on 2025-04-09

3616 Modeling spatial contrast sensitivity in responses of primate retinal ganglion cells to natural movies

Sridhar, S.; Vystrcilova, M.; Khani, M. H.; Karamanlis, D.; Schreyer, H. M.; Ramakrishna, V.; Krueppel, S.; Zapp, S. J.; Mietsch, M.; Ecker, A.; Gollisch, T.

10.1101/2024.03.05.583449 — neuroscience — Posted on 2025-04-09

3617 How Nasal Cavity Structure Influences Empty Nose Syndrome Severity: A CFD-Based Analysis

RUMIANO, A.; Dinh, T.

10.1101/2025.04.04.645990 — biophysics — Posted on 2025-04-09

3618 Evolutionary expression patterns in developing biofilms of uropathogenic Escherichia coli reveal embryo-like features

Tusar, A.; Koska, S.; Futo, M.; Kasalo, N.; Svetlicic, E.; Corak, N.; Domazet-Loso, M.; Franjevic, D.; Mijakovic, I.; Domazet-Loso, T.

10.1101/2025.04.04.647276 — evolutionary biology — Posted on 2025-04-09

3619 Current estimates of population resilience do not predict resilience to directional environmental shifts

Cant, J.; Hernandez, C. M.; Thornley, R.; Hector, A.; Stott, I.; Salguero-Gomez, R.

10.1101/2025.04.04.647258 — ecology — Posted on 2025-04-09

3620 Implementing N-terminomics and machine learning to probe in vivo Nt-arginylation

Ju, S.; Nawale, L.; Lee, S.; Kim, J. G.; Lee, H.; Park, N.; Kim, D. H.; Cha-Molstad, H.; Lee, C.

10.1101/2025.04.09.646507 — systems biology — Posted on 2025-04-09

3621 On-demand insulin manufacturing using cell-free systems with an "on-column" conversion approach

Borhani, S. G.; Levine, M. Z.; Gurramkonda, C.; Qu, Y.; Tao, D.; LeClair, C. A.; Swartz, J.; Rao, G.

10.1101/2025.04.08.633785 — synthetic biology — Posted on 2025-04-09

3622 GM1 and GD3 Gangliosides Attenuate NGF-TrkA and BDNF-TrkB Signaling Dysfunction Associated with Acute Diisopropylfluorophosphate Exposure in Mouse Brain

Itokazu, Y.; Beck, W. D.; Terry, A. V.

10.1101/2025.03.31.646417 — pharmacology and toxicology — Posted on 2025-04-09

3623 AMP-activated protein kinase (AMPK) is essential for tendon homeostasis and prevents premature senescence and ectopic calcification

Hold, L. A.; Migotsky, N.; Chen, J.; Steltzer, S. S.; Cordts, P.; Bae, S.-H.; Grossman, S.; Lamia, S.; Phillips, T.; O'Meara, M. J.; Davis, C. S.; Brooks, S. V.; Akbar, M.; Millar, N. L.; Killian, M. L.; Abraham, A. C.

10.1101/2025.01.31.635920 — pathology — Posted on 2025-04-09

3624 StainStyleSampler: Clustering-based sampling of whole slide image appearances

Silva, M. M. B.; Leh, S.; Weishaupt, H.

10.1101/2025.04.04.647194 — pathology — Posted on 2025-04-09

3625 IFI16 senses and protects stalled replication forks

Gamble, A.; Ward, T. A.; Wheeler, O. P.; Jones, C. M.; Bennett, L.; Vernon, E. G.; Thandendran, V.; Morris, J. P.; Ceppi, I.; Halder, S.; Borello, D.; Walker, T. D.; Rajan, J.; Dunphy, G.; Cejka, P.; Unterholzner, L.; Staples, C. J.

10.1101/2025.04.07.646548 — cancer biology — Posted on 2025-04-09

3626 Rhagovelia uses interfacial run-and-tumble locomotionto improve prey capture in flowing environments

Tiwari, I.; Nagappan, N.; Harrison, J. S.; Bhamla, S.

10.1101/2025.04.03.647112 — biophysics — Posted on 2025-04-09

3627 DeorphaNN: Virtual screening of GPCR peptide agonists using AlphaFold-predicted active-state complexes and deep learning embeddings

Ferguson, L.; Ouellet, S.; Vandewyer, E.; Wang, C.; Wunna, Z.; Lim, T. K. Y.; Schafer, W. R.; Beets, I.

10.1101/2025.03.19.644234 — bioinformatics — Posted on 2025-04-09

3628 A global P-Process map to avoid P-value abuse

Xu, J.; Wei, S.; Tao, J.; Sun, C.; Chen, H.; Duan, L.; Shang, Z.; Lyu, W.; Lyu, H.; Zhang, M.; Jiang, Y.

10.1101/2025.04.06.646254 — bioinformatics — Posted on 2025-04-09

3629 Self-contrastive learning enables interference-resilient and generalizable fluorescence microscopy signal detection without interference modeling

Zhang, F.; Huang, R.; Xin, M.; Meng, H.; Gao, D.; Fu, Y.; Gao, J.; Ji, X.

10.1101/2025.04.08.645087 — bioinformatics — Posted on 2025-04-09

3630 Robin: An Advanced Tool for Comparative Loop Caller Result Analysis Leveraging Large Language Models

Chowdhury, H. M. A. M.; Fuller, M.; Oluwadare, O. E.

10.1101/2025.04.05.646688 — bioinformatics — Posted on 2025-04-09

3631 Single-cell bacterial culturing and antibiotic susceptibility testing using permeable hydrogel-shelled microcapsules

Pratt, S. L.; Williamson, K. S.; Franklin, M. J.; Chang, C. B.

10.1101/2025.04.03.647129 — bioengineering — Posted on 2025-04-09

3632 Engineering IspH for Enhanced Terpenoid Yield: Computational and Molecular Dynamics Studies

Runthala, A.; Machrela, S.; Varadharajan, V.; Selvan, S. T.; Sharma, M.; Kaur, N.; Phulara, S. C.; Ahmad, S. N.; Ghneim, H. K.

10.1101/2025.04.07.643449 — bioengineering — Posted on 2025-04-09

3633 A gel-top model for characterizing mesenchymal features of glioblastoma cells

Pan, Y.; Chan, P.; Rich, J. N.; Kay, S. A.; Park, J.

10.1101/2025.04.03.647072 — bioengineering — Posted on 2025-04-09

3634 Gap-free genomes and transcriptomes uncover race-specific effectors in watermelon wilt pathogen Fusarium oxysporum f. sp. niveum

Ayhan, D. H.; Wang, H.; Zhang, L.; Wang, G.; Yi, S.; Meng, D.; Xue, L.; Geng, X.; Kong, Z.; Wang, X.; Wang, L.; Yang, Q.; Wang, X.; Deng, Y.; Zhang, X.; Guo, L.

10.1101/2025.04.04.647254 — genomics — Posted on 2025-04-09

3635 Macroevolutionary changes in natural selection on codon usage reflects evolution of the tRNA pool across a budding yeast subphylum

Cope, A. L.; Shah, P.

10.1101/2024.09.27.615277 — evolutionary biology — Posted on 2025-04-09

3636 Applications of Wedderburn's Theorem in Modelling Non-Commutative Biological and Evolutionary Systems

Tozzi, A.

10.1101/2025.04.03.647006 — evolutionary biology — Posted on 2025-04-09

3637 Combining fossil taxa with and without morphological data improves dated phylogenetic analyses

Nikolic, M. C.; Warnock, R. C. M.; Hopkins, M. J.

10.1101/2025.04.07.646048 — evolutionary biology — Posted on 2025-04-09

3638 Moving northwards: Invasive Green Crab (Carcinus maenas) Expands into the Southwestern Atlantic

Baigorria, M. M.; Narvarte, M.; Hunicken, L.

10.1101/2025.01.29.635464 — ecology — Posted on 2025-04-09

3639 Microtubule networks in zebrafish hair cells facilitate presynapse transport and fusion during development

Hussain, S.; Pinter, K.; Uhl, M.; Wong, H.-T.; Kindt, K. S.

10.1101/2024.04.12.589161 — developmental biology — Posted on 2025-04-09

3640 Multiscale characterization of Caenorhabditis elegans mutants to probe functional mechanisms of human actin pathological variants

Hecquet, T.; Arbogast, N.; Suhner, D.; Goetz, A.; Amann, G.; Yürekli, S.; Marangoni, F.; Greve, J. N.; Di Donato, N.; Reymann, A.-C.

10.1101/2024.07.22.604239 — cell biology — Posted on 2025-04-09

3641 Dynamic phosphorylation of Hcm1 promotes fitness in chronic stress

Conti, M. M.; Bail, J. P.; Reynolds, A. R.; Budge, L. G.; Flynn, M. J.; Li, R.; Zhu, L. J.; Benanti, J. A.

10.1101/2024.09.18.613713 — cell biology — Posted on 2025-04-09

3642 Blocking toxin function and modulating the gut microbiota: caffeic acid phenethyl ester as a potential treatment for Clostridioides difficile infection

Guo, Y.; Zhang, Y.; Wang, G.; Liu, H.; Wang, J.; Deng, X.; He, L.; Qiu, J.

10.1101/2024.08.19.608683 — microbiology — Posted on 2025-04-09

3643 Observation of persister cell histories reveals diverse modes of survival in antibiotic persistence

Umetani, M.; Fujisawa, M.; Okura, R.; Nozoe, T.; Suenaga, S.; Nakaoka, H.; Kussell, E.; Wakamoto, Y.

10.1101/2021.10.28.466227 — microbiology — Posted on 2025-04-09

3644 Glucocorticoid receptor activation reprograms NK cells to drive AREG-mediated immunosuppression in skin cancer

Wei, Q.; Liang, G.; Li, Y.; Zeng, R.; Hong, A.; Wang, H.; Feng, S.; Wang, Y.; Wang, Y.

10.1101/2023.09.13.557530 — immunology — Posted on 2025-04-09

3645 Subjective sleep quality in healthy young adults moderates associations of sensitivity to punishment and reward with functional connectivity of regions relevant for insomnia disorder

Zareba, M. R.; Davydova, T.; Palomar-Garcia, M.-A.; Adrian-Ventura, J.; Costumero, V.; Visser, M.

10.1101/2025.01.31.635885 — neuroscience — Posted on 2025-04-09

3646 Unraveling anti-inflammatory metabolic signatures of Glycyrrhiza uralensis and isoliquiritigenin through multiomics

Kiuchi, S.; Chung, M. H.; Nakaya, T.; Ohbuchi, K.; Tsumagari, K.; Imami, K.; Otoguro, Y.; Nitta, T.; Yamamoto, H.; Sasaki, K.; Tsugawa, H.

10.1101/2025.04.08.647718 — systems biology — Posted on 2025-04-09

3647 On modeling ovarian aging and menopause timing

Lawley, S. D.; Santoro, N.; Johnson, J.

10.1101/2025.04.07.647646 — physiology — Posted on 2025-04-09

3648 A Cheminformatics Workflow for Higher-throughput Modeling of Chemical Exposures from Biosolids

Kruse, P. M.; Ring, C. L.

10.1101/2025.04.03.647109 — pharmacology and toxicology — Posted on 2025-04-09

3649 TMT-based quantitative proteomic assessment of Vicia sativa induced neurotoxicity by β-cyano-L-alanine and γ-glutamyl-β-cyano-L-alanine in SH-SY5Y cells.

Riley, S.; Vy Nguyen, V.; Bhattacharjeec, R.; Ng, P. Q.; Ritchie, T. C.; Fisk, I.; Gecz, J.; Kumar, R.; Searle, I. R.

10.1101/2025.04.05.647336 — pharmacology and toxicology — Posted on 2025-04-09

3650 Mitochondrial Responses to Conventional and Ultra-high Dose Rate (FLASH) Radiation

Caggiano, E.; Lopez-Hernandez, A.; Waldrop, T.; Liu, K.; Gatica-Gutierrez, H.; Vargas-Hernandez, S.; Mims, N.; Acevedo-Diaz, A.; Velasquez, B.; Neil, D.; Aguilar, E.; Meyer, M.; Echeverria, G. V.; Koong, A.; Spiotto, M.; Gustavsson, A.-K.; Schueler, E. V.

10.1101/2025.04.03.647049 — cancer biology — Posted on 2025-04-09

3651 Resolving somatic SVs via full-length sequence model-based local graph-genome optimization

Tu, K.; Zhang, Q.; Li, Y.; Li, Y.; Yuan, L.; Wang, J.; Tang, J.; Xia, L.; Huang, W.; Xie, D.

10.1101/2025.02.11.636543 — bioinformatics — Posted on 2025-04-09

3652 Generalized Biological Foundation Model with Unified Nucleic Acid and Protein Language

He, Y.; Fang, P.; Shan, Y.; Pan, Y.; Wei, Y.; Chen, Y.; Chen, Y.; Liu, Y.; Zeng, Z.; Zhou, Z.; Zhu, F.; Holmes, E. C.; Ye, J.; Li, J.; Shu, Y.; Shi, M.; Li, Z.

10.1101/2024.05.10.592927 — bioinformatics — Posted on 2025-04-09

3653 Bridging data gaps: predicting inadequate micronutrient intake with machine learning

Voukelatou, V.; Tang, K.; Lauzana, I.; Jangid, M.; Martini, G.; de Pee, S.; Knight, F.; Piovani, D.

10.1101/2025.04.08.647715 — bioinformatics — Posted on 2025-04-09

3654 NetSyn: genomic context exploration of protein families

Stam, M.; Langlois, j.; Chevalier, C.; Mainguy, J.; Reboul, G.; Bastard, K.; Medigue, C.; Vallenet, D.

10.1101/2023.02.15.528638 — bioinformatics — Posted on 2025-04-09

3655 An automated metabolite extraction workflow for global metabolomics analysis using the Agilent Bravo liquid handling platform

Massie, F.; MacKenzie, A.; Pandor, S.; Cremonini, M. A.; Moses, T.

10.1101/2025.04.07.647543 — biochemistry — Posted on 2025-04-09

3656 JAK-STAT pathway activation compromises nephrocyte function in a Drosophila high-fat diet model of chronic kidney disease

Zhao, Y.; Duan, J.; Seah, H.; van de Leemput, J.; Han, Z.

10.1101/2024.03.07.583967 — cell biology — Posted on 2025-04-09

3657 Lysine deacetylation inhibition reverses TDP-43 mislocalization and in combination with arimoclomol ameliorates neuromuscular pathology

Scozzari, S.; Columbro, S. F.; Favagrossa, M.; Tortarolo, M.; Cagnotto, A.; Salmona, M.; De Marco, G.; Bendotti, C.; Calvo, A.; Pasetto, L.; Bonetto, V.

10.1101/2024.12.15.628528 — neuroscience — Posted on 2025-04-09

3658 SLC44A1 deficiency impedes myelin development in the central nervous system

Chen, Q.; Chen, X.; Li, Z.-H.; Shao, Q.; Huang, H.; Zhou, W.; Qiu, M.; Su, Z.; Liu, P.; He, C.

10.1101/2025.04.08.647819 — neuroscience — Posted on 2025-04-09

3659 A vectorial code for semantics in human hippocampus

Franch, M.; Mickiewicz, E. A.; Belanger, J.; Chericoni, A.; Chavez, A. G.; Katlowitz, K.; Mathura, R.; Paulo, D.; Bartoli, E.; Kemmer, S.; Piantadosi, S. T.; Provenza, N.; Watrous, A.; Sheth, S.; Hayden, B.

10.1101/2025.02.21.639601 — neuroscience — Posted on 2025-04-09

3660 Force-insensitive myosin-I enhances endocytosis robustness through actin network-scale collective ratcheting

Ferrin, M. A.; Pedersen, R. T.; Drubin, D. G.; Akamatsu, M.

10.1101/2025.04.04.647278 — biophysics — Posted on 2025-04-09

3661 Characterization of binding kinetics and intracellular signaling of new psychoactive substances targeting cannabinoid receptor using transition-based reweighting method

Dutta, S.; Shukla, D.

10.1101/2023.09.29.560261 — biophysics — Posted on 2025-04-09

3662 Ecological niche differentiation mediates near complete premating reproductive isolation within the Gladiolus carneus (Iridaceae) species complex.

Khoury, K. L.; Edwards, S.; Newman, E. L.

10.1101/2025.04.04.647161 — evolutionary biology — Posted on 2025-04-09

3663 Bounded environmental stochasticity generates secondary Allee thresholds

Schreiber, S.

10.1101/2025.04.03.647087 — ecology — Posted on 2025-04-09

3664 Gaps and Advances in Long-Term Monitoring of Antarctic Near-Shore and Terrestrial Ecosystems

Borgmeier, A.; Bergstrom, D.; Cary, S. C.; Convey, P.; Cummings, V.; Deregibus, D.; Hong, S. G.; Lee, C. K.; Lee, H.; Libertelli, M.; Robinson, S.; Schiaparelli, S.; Sultan, E.; Tsujimoto, M.; Verleyen, E.; Adams, B. J.

10.1101/2025.04.03.647064 — ecology — Posted on 2025-04-09

3665 Landscape suitability and range expansion estimates for the North American Interior Population of trumpeter swans

Barnes, K. W.; Cooper, T. R.; Andersen, D. E.; Estey, M. E.; Wolfson, D. W.

10.1101/2025.04.03.647047 — ecology — Posted on 2025-04-09

3666 Biobanking of Biological Samples at Room Temperature

Vangala, R. K.; Kanukollu, S.; M S, P.; Nair, J.; Vangala, A. B.; Shankar, A.; Upadhyay, B.; Palpandi, S.; Nagendran, J.; Nair, P. N.; Murugaian, E. E.

10.1101/2025.04.08.646969 — molecular biology — Posted on 2025-04-09

3667 N-Terminal Deleted Isoforms of E3 Ligase RNF220 (Isoform 4) Are Ubiquitously Expressed and Required for Mouse Muscle Differentiation.

Choi, S.; Wolfgeher, D. J.; Kim, J.; Go, Y.-H.; Cha, H.-J.; Bae, G.-U.; Kron, S. J.; Kim, W.-Y.

10.1101/2025.04.07.647521 — molecular biology — Posted on 2025-04-09

3668 The piRNA PETPIR Regulates Trophoblast Function by Modulating YTHDF2-Mediated m6A Methylation of NDRG1 in Preeclampsia

Zhao, Y.; Liang, S.; Guo, M.; Huang, S.; Yang, H.; Chen, X.; Li, S.-S.; Jin, X.

10.1101/2025.04.07.647678 — molecular biology — Posted on 2025-04-09

3669 AXL-GAS6/PROS1 Interaction: A Critical Switch Between Aberrant- and Healthy Repair Following Alveolar Lung Injury

Soetopo, D.; Mayr, C. H.; Fundel-Clemens, K.; Ramirez, F.; Viollet, C.; Dick, A.; Rust, W.; Santacruz, D.; Hoevels, Y.; Applebee, C. J.; Legg, S.; Funk, A.; Schnapp, G.; Padget, J.; Strobel, B.; Thomas, M. J.; Ward, S. G.; Larijani, B.; Geillinger-Kaestle, K.

10.1101/2025.04.07.647567 — molecular biology — Posted on 2025-04-09

3670 Protective Effects of Minocycline and Acetazolamide on Visual Function in Simulated Microgravity Rats

liu, j.; Naiqin, Y.; Yingyan, M.; Chen, X.; Dapeng, M.; Ningli, W.; zhu, s.

10.1101/2025.04.06.647441 — molecular biology — Posted on 2025-04-09

3671 Context-dependent Interactors Regulate TDP-43 Dysfunction in ALS/FTLD

Xie, L.; Zhu, Y.; Hurtle, B. T.; Wright, M.; Robinson, J. L.; Mauna, J. C.; Brown, E. E.; Ngo, M.; Bergmann, C. A.; Xu, J.; Merjane, J.; Gleixner, A. M.; Grigorean, G.; Liu, F.; Rossoll, W.; Lee, E. B.; Kiskinis, E.; Chikina, M.; Donnelly, C. J.

10.1101/2025.04.07.646890 — molecular biology — Posted on 2025-04-09

3672 Structure-Based Classification of CRISPR/Cas9 Proteins: A Machine Learning Approach to Elucidating Cas9 Allostery

Madugula, S. S.; Jayasinghe-Arachchige, V. M.; Norgan Radler, C.; Wang, S.; Liu, J.

10.1101/2025.04.05.647395 — pharmacology and toxicology — Posted on 2025-04-09

3673 Predicting Treatment Outcomes from Adaptive Therapy -- A New Mathematical Biomarker

Gallagher, K.; Strobl, M. A. R.; Maini, P. K.; Anderson, A. R. A.

10.1101/2025.04.03.646615 — cancer biology — Posted on 2025-04-09

3674 Hypoxic-Core (HyCo) Spheroids Recapitulate Hallmarks of Clinical Hypoxia: A Simple Chip-Based Method for Translational Oncology

Refet-Mollof, E.; Chermat, R.; Lafontaine, J.; Ye, R. Z.; Gervais, T.; Wong, P.

10.1101/2025.04.03.647075 — cancer biology — Posted on 2025-04-09

3675 Solid-state nanopore sensing reveals conformational changes induced by a mutation in a neuron-specific tRNAArg

Dutt, S.; Lai, L. B.; Mehta, R.; Karawdeniya, B. I.; Bandara, Y. M. N. D. Y.; Clulow, A. J.; Glatt, S.; Gopalan, V.; Kluth, P.

10.1101/2025.04.08.647894 — biophysics — Posted on 2025-04-09

3676 Mycolic acid like lipids act as substrates for Mycobacterium tuberculosis melH

Chakraborti, S.; Sistla, J. S.

10.1101/2025.04.06.646916 — biochemistry — Posted on 2025-04-09

3677 Identification of ESBL-producing enterobacterales from vegetable plants in a rural area of Madagascar: insights into AMR transmission at the human-animal-environment-plant interface

RIEUX, A.; Rabenandrasana, M. A. N.

10.1101/2025.04.06.647499 — genomics — Posted on 2025-04-09

3678 A novel regulator of the fungal phosphate starvation response revealed by transcriptional profiling and DNA affinity purification sequencing

Huberman, L. B.; Wu, V. W.; Kowbel, D. J.; Lee, J.; Daum, C.; Singan, V. R.; Grigoriev, I. V.; O'Malley, R. C.; Glass, L.

10.1101/2025.04.07.647663 — genetics — Posted on 2025-04-09

3679 D-Lactate drives cytotoxicity in Th1 cells by limiting mitochondrial ROS production through enhanced glyoxalase system activity

Madrigal-Aviles, A.; Plajer, V.; Serve, S.; Dzamukova, M.; Soriano-Baget, L.; Brenner, D.; Mashreghi, M.-F.; Loehning, M.

10.1101/2025.04.03.647060 — immunology — Posted on 2025-04-09

3680 Generation of two Betacellulin CRISPR-Cas9 knockout hiPSC lines to study affected EGF system paradigm in Schizophrenia

Cota-Coronado, A.; Manning, M.; Kim, D.-H.; Lee, J.; Gibbons, A.; Rosenbluh, J.; Hill, R.; Sundram, S.

10.1101/2025.04.07.647671 — neuroscience — Posted on 2025-04-09

3681 Antibiotic Use and Resistance in Zambia's Aquaculture Sector: Assessing Knowledge, Attitudes, and Practices Among Fish Farmers

Ndashe, K.; Mainda, G.; Makungu, C.; Caudell, M.; Changula, K.; Mtui-Malamsha, N.; Kimani, T.; Muma, J.; Nyirenda, M.; Sinkala, M.; Hang'ombe, B.

10.1101/2025.04.07.647520 — scientific communication and education — Posted on 2025-04-09

3682 C-terminal fusion partner activity contributes to the oncogenic functions of YAP1::TFE3

Cimino, P. J.; Keiser, D. J.; Parrish, A. G.; Holland, E. C.; Szulzewsky, F.

10.1101/2025.04.04.647316 — cancer biology — Posted on 2025-04-09

3683 Deciphering Structural Complexity of Brain, Joint, and Muscle Tissues Using Fourier Ptychographic Scattered Light Microscopy

van Staalduine, S. E.; Bianco, V.; Ferraro, P.; Menzel, M.

10.1101/2024.11.28.625428 — biophysics — Posted on 2025-04-09

3684 CDState: an unsupervised approach to predict malignant cell heterogeneity in tumor bulk RNA-sequencing data

Kraft, A.; Yates, J.; Barkmann, F.; Boeva, V.

10.1101/2025.03.01.641017 — bioinformatics — Posted on 2025-04-09

3685 Genomic Tokenizer: Toward a biology-driven tokenization in transformer models for DNA sequences

Eapen, B. R.

10.1101/2025.04.02.646836 — bioinformatics — Posted on 2025-04-09

3686 RNAchat: Integrating machine learning algorithms to identify metapathways based on clinical and multi-omics data

Tang, M.

10.1101/2025.04.02.646761 — bioinformatics — Posted on 2025-04-09

3687 ReCycled: A Tool to Reset the Start of Circular Bacterial Chromosomes

Somerville, V.; Schmid, M.; Dreier, M.; Engel, P.

10.1101/2025.04.07.647662 — bioinformatics — Posted on 2025-04-09

3688 A Bioinformatic Investigation into the Role of ITGB1 in Cancer Prognosis and Therapeutic Resistance

Mo, X.

10.1101/2025.04.06.647487 — bioinformatics — Posted on 2025-04-09

3689 CoExpPhylo - A Novel Pipeline for Biosynthesis Gene Discovery

Gruenig, N.; Pucker, B.

10.1101/2025.04.03.647051 — bioinformatics — Posted on 2025-04-09

3690 The South American MicroBiome Archive (saMBA): Enriching the healthy microbiome concept by evaluating uniqueness and biodiversity of neglected populations

Valderrama, B.; Calderon-Romero, P.; Bastiaanssen, T. F. S.; Lavelle, A.; Clarke, G.; Cryan, J. F.

10.1101/2025.04.03.647034 — bioinformatics — Posted on 2025-04-09

3691 Dosing and Delivery of Bacteriophage Therapy In a Murine Wound Infection Model

Lin, Y.-H.; Dharmaraj, T.; Chen, Q.; Echterhof, A.; Manasherob, R.; Zhang, L. J.; Li, Z.; de Leeuw, C.; Peterson, N. A.; Chang, T. H. W.; Stannard, W.; Hajfathalian, M.; Hargil, A.; Martinez, H. A.; Pourtois, J.; Blankenberg, F. G.; Amanatullah, D.; Chaudhuri, O.; Bollyky, P. L.

10.1101/2024.05.07.593005 — bioengineering — Posted on 2025-04-09

3692 Polysialylated NCAM distinguishes differentiated myoblasts from proliferating myoblasts prior to fusion

Kikuchi, T.; Shimizu, T.

10.1101/2025.04.08.647904 — cell biology — Posted on 2025-04-09

3693 Toxoplasma gondii RAD51 recombinase is required to overcome DNA replication stress and its inactivation leads to bradyzoite differentiation

Cartagena, A. M. S.; Arias, A. A.; Cristaldi, C.; Ganuza, A.; Gonzalez, M. M.; Corvi, M. M.; Sullivan, W. J.; Vanagas, L.; Angel, S. O.

10.1101/2025.04.08.647840 — molecular biology — Posted on 2025-04-08

3694 OPUS-TOMO: Deep Learning Framework for Structural Heterogeneity Analysis in Cryo-electron Tomography

Luo, Z.; Chen, X.; Wang, Q.; Ma, J.

10.1101/2024.06.30.601442 — molecular biology — Posted on 2025-04-09

3695 Genomic Reconstruction and Dietary Response Assessment of Three Clostridium leptum-related Bacteria Isolated from Fecal Samples of Singapore Subjects.

Park, M. A.; Almunawar, S. N. A.; Lim, R. R. X.; Haldar, S.; Henry, C. J.; Moskvin, O. V.

10.1101/2024.09.13.612987 — microbiology — Posted on 2025-04-09

3696 Cell division protein A (CdpA) organises and anchors the division ring at midcell in haloarchaea

Liao, Y.; Shinde, V. D.; Hu, D.; Xu, Z.; Soderstrom, B.; Michie, K. A.; Duggin, I. G.

10.1101/2024.07.17.603854 — microbiology — Posted on 2025-04-09

3697 Minimal machine learning models of resistance identify novel antibiotic resistance discovery opportunities in Klebsiella pneumoniae

Kordova, K.; Collins, C.; Parkhill, J.

10.1101/2025.04.08.647753 — microbiology — Posted on 2025-04-09

3698 m6A regulates ADAR1-mediated RNA editing during macrophage activation

Griesche, V.; Di Giorgio, S.; Tellioglu, I.; Kao, C.-Y.; Lorenzo, J. P.; Pezzella, L.; Brettschneider, J.; Stoecklin, G.; Papavasiliou, F. N.

10.1101/2025.01.28.635339 — immunology — Posted on 2025-04-09

3699 The complexity and commonness of the two-process model of sleep regulation from a mathematical perspective

Skeldon, A. C.; Dijk, D.-J.

10.1101/2025.01.22.634299 — neuroscience — Posted on 2025-04-09

3700 Discovery, Interruption, and Updating of Auditory Regularities in Memory: Evidence from Low-Frequency Brain Dynamics in Human MEG

Bianco, R.; magami, K.; Pearce, M.; Chait, M.

10.1101/2025.03.28.645906 — neuroscience — Posted on 2025-04-09

3701 Mathematical modelling of macrophage and natural killer cell immune response during early stages of peritoneal endometriosis lesion onset

Miller, C.; Germano, D. P. J.; Chenoweth, A. M.; Holdsworth-Carson, S.

10.1101/2025.01.20.633967 — systems biology — Posted on 2025-04-09

3702 A lipidomic exploration of the effects of high-intensity interval exercise in healthy men after metformin intake

Neuhaus, R.; Meikopoulos, T.; Gradillas, A.; Gonzalez-Riano, C.; Theodoridis, G.; Nikolaidis, S.; Mougios, V.; Barbas, C.; Gika, H.; VILLASENOR, A.

10.1101/2025.04.02.646809 — systems biology — Posted on 2025-04-09

3703 Exosomal cargo genes as biomarkers and potential mediators of exosome-driven cell communication in Pleural Mesothelioma

Kraft, A.; Toenz, A.; Schlaepfer, F.; Ronner, M.; Orlowski, V.; Kirschner, M. B.; Bein, J.; Wild, P. J.; Boeva, V.; Opitz, I.; Meerang, M.

10.1101/2025.04.04.647264 — cancer biology — Posted on 2025-04-09

3704 Exploiting macropinocytosis for therapeutic intervention in RAS mutant Multiple Myeloma

Beals, N.; Ramirez, C.; Koide, A.; Hauser, A. D.; Davies, F.; Koide, S.; Morgan, G.; Bar-Sagi, D.

10.1101/2025.04.04.647098 — cancer biology — Posted on 2025-04-09

3705 Proteostasis control via HSP90α sustains YAP activity to drive aggressive behaviours in cancer-associated fibroblasts

Dominguez-Garcia, S.; Rodriguez, J.; Julia, M.; Coursier, D.; Perez-Lopez, C.; Carnicero, P.; Villar, A. V.; von Kriegsheim, A.; Calvo, F.

10.1101/2025.04.04.647210 — cancer biology — Posted on 2025-04-09

3706 Genome-wide profiling identifies the genetic dependencies of cell death following EGFR inhibition

Porto, S. A.; Birdsall, G. A.; Harper, N. W.; Honeywell, M. E.; Lee, M. J.

10.1101/2025.04.04.647273 — cancer biology — Posted on 2025-04-09

3707 Improving single molecule localisation microscopy reconstruction by extending the temporal context

Reinhard, S.; Ebert, V.; Schrama, J.; Sauer, M.; Kollmannsberger, P.

10.1101/2025.04.05.647262 — biophysics — Posted on 2025-04-09

3708 The role of active mRNA-ribosome dynamics and closing constriction in daughter chromosome separation in Escherichia coli

Amarasinghe, C. I.; Chang, M.-H.; Männik, J.; Retterer, S. T.; Lavrentovich, M. O.; Männik, J.

10.1101/2025.04.05.647368 — biophysics — Posted on 2025-04-09

3709 Polymorphic tandem repeats influence cell type-specific gene expression across the human immune landscape

Tanudisastro, H. A.; Cuomo, A. S. E.; Weisburd, B.; Welland, M.; Spenceley, E.; Franklin, M.; Xue, A.; Bowen, B.; Wing, K.; Tang, O.; Gray, M.; Reis, A. L. M.; Margoliash, J.; Kurtas, E. N.; Pullin, J.; Lee, A. S.; Brand, H.; Harper, M.; Bobowik, K.; Silk, M.; Marshall, J.; Bakiris, V.; Swapna Madala, B.; Uren, C.; Bartie, C.; Senabouth, A.; Dashnow, H.; Fearnley, L.; Martin Trujillo, A.; Dolzhenko, E.; Qiao, Z.; Grieve, S.; Nguyen, T.; Ben-David, E.; Chen, L.; Farh, K.; Talkowski, M.; Alexander, S. I.; Siggs, O. M.; Gruenschloss, L.; Nicholas, H. R.; Piscionere, J.; Simons, C.; Wallace, C.; G

10.1101/2024.11.02.621562 — genomics — Posted on 2025-04-09

3710 Phenotypic plasticity meets and moulds carry-over effects in sea rock-pool mosquitoes

Cordeschi, G.; Bisconti, R.; Mastrantonio, V.; Canestrelli, D.; Porretta, D.

10.1101/2024.07.24.604954 — ecology — Posted on 2025-04-09

3711 Sphingolipid imbalance aggravates tau pathology by endomembrane rigidification and rupture

Tittelmeier, J.; Sandhof, C. A.; Martin, N.; El-Kabarity, D.; Ngonza-Nito, S.-B.; Melki, R.; Nussbaum-Krammer, C.

10.1101/2024.10.24.619578 — cell biology — Posted on 2025-04-09

3712 CetZ1-dependent polar assembly of the archaeal motility machinery

Brown, H. J.; Islam, M. I.; Ruan, J.; Baker, M. A.; Ithurbide, S.; Duggin, I. G.

10.1101/2024.05.02.592137 — microbiology — Posted on 2025-04-09

3713 Functional Role for Cas Cytoplasmic Adaptor Proteins During Cortical Axon Pathfinding

Estep, J. A.; Treptow, A. M.; DePalma, P. A.; Williamson, P.; Wong, W.; Riccomagno, M. M.

10.1101/2025.04.08.647868 — neuroscience — Posted on 2025-04-09

3714 Genetic diversity shapes behavioral outcomes and reveals sex differences in mice exposed to early life stress

Nguyen, J.; Shimizu, K.; Zlotnik, V.; Nguyen, M. N.; Del Toro, S.; Nguyen, M. T.; Ronquillo, J.; Halladay, L. R.

10.1101/2025.04.08.647890 — neuroscience — Posted on 2025-04-09

3715 Insights into early cochlear damage induced by potassium channel deficiency

Rias, E.; Carignano, C.; Castagna, V. C.; Dionisio, L.; Ballestero, J. A.; Paolillo, G.; Ouwerkerk, I.; Gomez-Casati, M. E.; Spitzmaul, G.

10.1101/2025.04.08.647809 — neuroscience — Posted on 2025-04-09

3716 Identification of a stress-sensitive endogenous opioid-containing neuronal population in the paranigral ventral tegmental area.

Stine, C.; Marcus, D. J.; Pasqualini, A. L.; Achanta, A. S.; Johnson, J. C.; Jadhav, S.; Bruchas, M. R.

10.1101/2025.04.08.647881 — neuroscience — Posted on 2025-04-09

3717 The precision of hippocampal representations predicts incremental value-learning across the adult lifespan

vanGeen, C.; Lempert, K. M.; Cohen, M.; MacNear, K. A.; Reckers, F. M.; Zaneski, L.; Kable, J. W.; Wolk, D.

10.1101/2025.04.08.647815 — neuroscience — Posted on 2025-04-09

3718 Evaluating MINFLUX experimental performance in silico

Marin, Z.; Ries, J.

10.1101/2025.04.08.647786 — biophysics — Posted on 2025-04-08

3719 Development and social dynamics of stone tool use in white-faced capuchin monkeys

Goldsborough, Z.; Carlson, M. K. W.; Reetz, L.; Crofoot, M. C.; Barrett, B. J.

10.1101/2025.04.08.647785 — animal behavior and cognition — Posted on 2025-04-08

3720 Assessing the potential of ancient protein sequences in the study of hominid evolution

Patramanis, I.; Cappellini, E.; Racimo, F.

10.1101/2025.04.08.647730 — evolutionary biology — Posted on 2025-04-08

3721 Functional genomics analysis of developing zebrafish and human endoderm reveals highly conserved cis-regulatory modules controlling vertebrate organogenesis

Figiel, D. M.; Elsayed, R.; Walsh, M. D.; Johal, S.; Lin, Y.; Bretschneider, T.; Ott, S.; Nelson, A. C.

10.1101/2025.04.08.647835 — developmental biology — Posted on 2025-04-08

3722 HuR-Driven Reversible Mitochondrial Shuttling Buffers Cytosolic miRNA Levels in Hepatic Cells

Banerjee, S.; Hom Choudhury, S.; Chatterjee, S.; Hu, G.; Mukherjee, K.; Bhattacharyya, S. N.

10.1101/2025.04.08.647748 — cell biology — Posted on 2025-04-08

3723 COP9 signalosome and PRMT5 methylosome complexes are essential regulators of Lis1-dynein based transport

Gupta, D.; Maddika, S.

10.1101/2025.04.08.647777 — cell biology — Posted on 2025-04-08

3724 Autism-associated Scn2a haploinsufficiency disrupts in vivo dendritic signaling and impairs flexible decision-making

Wu, H.; Shen, L.; Indajang, J.; Savalia, N. K.; Johnson, T. G.; Qu, J.; Bender, K. J.; Kwan, A. C.

10.1101/2025.04.08.647866 — neuroscience — Posted on 2025-04-09

3725 Ontogeny of tactile, vocal and kinship dynamics in rat pup huddling

Rocha-Almeida, F.; Takemoto, H.; Clemens, A. M.

10.1101/2025.04.08.647436 — neuroscience — Posted on 2025-04-09

3726 Transcription factor hubs exhibit gene-specific properties that tune expression

Fallacaro, S.; Mukherjee, A.; Turner, M. A.; Garcia, H. G.; Mir, M.

10.1101/2025.04.07.647578 — biophysics — Posted on 2025-04-08

3727 NAD+ Sensing by PARP7 Regulates the C/EBPβ-Dependent Transcription Program in Adipose Tissue In Vivo

Stokes, M. S.; Kim, Y. J.; Kim, Y.; Koul, S.; Chiu, S.-P.; Dasovich, M.; Zuniga, J.; Nandu, T.; Huang, D.; Mathews, T. P.; Solmonson, A.; Camacho, C. V.; Kraus, W. L.

10.1101/2025.04.07.647692 — cell biology — Posted on 2025-04-08

3728 Actin cytoskeletal remodeling requires the interaction between Solo and LARG in response to substrate stiffness

Kunitomi, A.; Toyofuku, Y.; Chiba, S.; Higashitani, N.; Higashitani, A.; Sato, S.; Mizuno, K.; Ohashi, K.

10.1101/2025.04.08.647765 — cell biology — Posted on 2025-04-08

3729 Unraveling Systemic Responses to NQO1-Activated IB-DNQand Rucaparib Single and Dual Agent Therapy in Triple-Negative Breast Cancers

Runnebohm, A. M.; Wijeratne, H. S.; Peck Justice, S. A.; Wijeratne, A. B.; Roy, G.; Smith, J. J.; Singh, N.; Hergenrother, P.; Boothman, D. A.; Motea, E. A.; Mosley, A. L.

10.1101/2024.05.15.594427 — cancer biology — Posted on 2025-04-08

3730 Identifying the proximate mechanisms that generate variation in nutritional plasticity for fecundity in Drosophila melanogaster

Nogueira Alves, A.; Chakraborty, A.; Wansbrough, M.; Walter, G. M.; Piper, M. D. W.; Sgro, C. M.; Mirth, C. K.

10.1101/2023.03.07.531575 — evolutionary biology — Posted on 2025-04-08

3731 Cortical microtubules act as a template to organize nano-scale patterning of the SEC/MUNC protein KEULE and exocytosis

Lindeboom, J.; Gutierrez, R.; Kirik, V.; Ehrhardt, D. W.

10.1101/2024.12.01.626273 — cell biology — Posted on 2025-04-08

3732 Adenovirus maturation establishes the transcription competent packaging of its genome

Baumgartl, C.; Holzinger, S.; Schwartz, U.; Franken, L. E.; Gruenewald, K.; Wodrich, H.; Laengst, G.

10.1101/2025.04.08.647783 — molecular biology — Posted on 2025-04-08

3733 Extended-spectrum beta-lactamase (ESBL)-producing E. coli in livestock and free-roaming wildlife: a combined phenotyping whole-genome sequencing One Health approach

Conforti, S.; Kapopoulou, A.; Bank, C.; Koechle, B.; Yilmaz, B.; Becker, J.

10.1101/2025.04.08.647752 — molecular biology — Posted on 2025-04-08

3734 Detection of archaeal- and prokaryotic-like ribosome exit tunnels within eukaryotic kingdoms

Yu, S.; Kushner, A.; Srebnik, S.; Duc, K. D.

10.1101/2025.04.08.647849 — molecular biology — Posted on 2025-04-08

3735 Investigation of the global translational response to oxidative stress in the model archaeon Haloferax volcanii reveals untranslated small RNAs with ribosome occupancy

Dallon, E.; Moran, H. M.; Chidambaran, S. R.; Kian, A.; Huang, B. Y.; Fried, S. D.; DiRuggiero, J.

10.1101/2025.04.08.647799 — microbiology — Posted on 2025-04-08

3736 Pathogenic potential prediction of Vibrio parahaemolyticus by using pangenome data with high performance machine learning algorithms

Liu, Z.; Li, Z.; Zhang, J.; Brown, C. T.; Wang, L.

10.1101/2025.04.08.647818 — microbiology — Posted on 2025-04-08

3737 High-throughput detection and quantification of vitamin B12 in microbiome isolates using Escherichia coli

Hencel, K.; Sullivan, M.; Akay, A.

10.1101/2025.04.08.647760 — microbiology — Posted on 2025-04-08

3738 A local composition of peptidoglycan drives the division site selection by MapZ in Streptococcus pneumoniae

Ducret, A.; Freton, C.; Grangeasse, C.

10.1101/2025.04.08.647842 — microbiology — Posted on 2025-04-08

3739 Plant pathogenic Ralstonia share two core methyl-accepting chemoreceptors that drive chemotaxis toward distinct amino acid profiles

Avalos, J. K.; Elmgreen, V.; Guerrero, C. R.; Grulla, K. J.; Miqueo, K.; Parales, R. E.; Lowe-Power, T. M.; Schomer, R. A.

10.1101/2025.04.07.647700 — microbiology — Posted on 2025-04-08

3740 Molecular interplay between ComEC domains leads to efficient DNA translocation during natural transformation

Stedman, M. J. M.; Deselaers, S.; Braus, S. A. G.; Wang, D.; Gregori Balaguer, M.; Gossert, A. D.; Hospenthal, M. K.

10.1101/2025.04.08.647572 — microbiology — Posted on 2025-04-08

3741 Assessing the efficiency and the side effects of atrazine-degrading biocomposites amended to atrazine-contaminated soil

Abbasi, S.; Devers-Lamrani, M.; Martin-Laurent, F.; Michel, C.; Romdhane, S.; Rouard, N.; Spor, A.

10.1101/2025.04.08.647713 — microbiology — Posted on 2025-04-08

3742 Evolutionary plasticity of bacterial surface layer protein exoskeletons

Barwinska-Sendra, A.; Salgado, P. S.; Sendra, K. M.

10.1101/2025.04.02.646754 — microbiology — Posted on 2025-04-08

3743 A universal power law optimizes energy and representation fidelity in visual adaptation

Mariani, M.; Moosavi, A. S.; Ringach, D.; Dipoppa, M.

10.1101/2025.03.20.643406 — neuroscience — Posted on 2025-04-08

3744 Visual pathway origins: an electron microscopic volume for connectomic analysis of the human foveal retina

Kim, Y. J.; Packer, O.; Macrina, T.; Pollreisz, A.; Curcio, C. A.; Lee, K.; Kemnitz, N.; Ih, D.; Nguyen, T.; Lu, R.; Popovych, S.; Halageri, A.; Bae, J. A.; Strout, J.; Gerhard, S.; Smith, R. G.; Martin, P. R.; Grünert, U.; Dacey, D.

10.1101/2025.04.05.647403 — neuroscience — Posted on 2025-04-08

3745 Novel Aromatic Polyhydroxyalkanoates from Engineered Cupriavidus necator H16: Expanding Bio-Polyester Synthesis from Renewable Feedstocks

Averesch, N. J. H.; Pane, V. E.; Kracke, F.; Chatterjee, S.; Berliner, A. J.; Ziesack, M.; Nangle, S. N.; Waymouth, R. M.; Criddle, C. S.

10.1101/2021.12.12.472320 — synthetic biology — Posted on 2025-04-08

3746 Cellular characterization of the mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cells

Zawieja, S. D.; Pea, G. A.; Broyhill, S. E.; Patro, A.; Bromert, K. H.; Norton, C. E.; Kim, H. J.; Sivasankaran, S. K.; Li, M.; Castorena-Gonzalez, J. A.; Drumm, B. T.; Davis, M. J.

10.1101/2023.08.24.554619 — physiology — Posted on 2025-04-08

3747 Menin-MLL1 complex cooperates with NF-Y to promote HCC survival

Dzama-Karels, M.; Kuhlers, P.; Sokolowski, M.; Brinkman, J. A.; Morris, J. P.; Raab, J. R.

10.1101/2025.04.05.647381 — cancer biology — Posted on 2025-04-08

3748 Demethylating agents drive PARP inhibitor resistance in ovarian carcinomas with BRCA1 gene silencing

Nesic, K.; Geissler, F.; Xu, L.; Kyran, E.; Beard, S.; Vandenberg, C. J.; Liddell, B.; Olechnowicz, S. W. Z.; Topp, M.; McNally, O.; Ratnayake, G.; Traficante, N.; Australian Ovarian Cancer Study, ; DeFazio, A.; Bowtell, D. D. L.; Pappenfuss, T.; Zhang, F.; Dobrovic, A.; Waddell, N.; Scott, C. L.; Kondrashova, O.; Wakefield, M. J.

10.1101/2025.04.07.647418 — cancer biology — Posted on 2025-04-08

3749 Learning the dynamic organization of a replicating bacterial chromosome from time-course Hi-C data

Harju, J.; Messelink, J. J. B.; Troeger, L.; Gradziuk, G.; Rathnayaka, I.; Thanbichler, M.; van Teeseling, M. C. F.; Broedersz, C. P.

10.1101/2025.04.03.647011 — biophysics — Posted on 2025-04-08

3750 OmniSplice: a framework-free splicing event reporter

Lannes, R.; Fingerhut, J. M.; Yamashita, Y. M. M.

10.1101/2025.04.06.647416 — bioinformatics — Posted on 2025-04-08

3751 Incorporating Multi-threshold Polygenic Risk in Hippocampal-based Normative Models Improves Cognitive Decline Prediction

Janahi, M.; Altmann, A.; Mokrab, Y.; Barkhof, F.; Oxtoby, N.; Lorenzini, L.

10.1101/2025.04.03.646991 — bioinformatics — Posted on 2025-04-08

3752 Experimental investigation of oxygen diffusion in the peak and valley region of minibeam patterns during X-Ray irradiation

Schorling, C.; Rauth, E.; Stengl, C.; Seco, J.

10.1101/2025.04.06.647386 — biochemistry — Posted on 2025-04-08

3753 Activation of SPARDA defense system by filament assembly reveals beta-relay signaling mechanism widespread in prokaryotic Argonautes

Jurgelaitis, E.; Zagorskaite, E.; Kopustas, A.; Asmontas, S.; Manakova, E.; Dalgediene, I.; Tylenyte, U.; Silanskas, A.; Toliusis, P.; Grybauskas, A.; Tutkus, M.; Venclovas, C.; Zaremba, M.

10.1101/2025.04.08.647717 — biochemistry — Posted on 2025-04-08

3754 Isotope tracing-based metabolite identificationfor mass spectrometry metabolomics

Secilmis, D.; Begzati, A.; Grankvist, N.; Roci, I.; Watrous, J.; Majithia, A. R.; Smith, G. I.; Klein, S.; Jain, M.; Nilsson, R.

10.1101/2025.04.07.647691 — biochemistry — Posted on 2025-04-08

3755 Structural basis for the ubiquitin chain recognition of the human 26S proteasome

Amann, S. J.; Kalis, R.; Fottner, M.; Knaudt, H.; Grishkovskaya, I.; Kotisch, H.; Zuber, J.; Lang, K.; Brown, N. G.; Haselbach, D.

10.1101/2025.04.07.647569 — biochemistry — Posted on 2025-04-08

3756 Characterization of the Mechanisms Underlying Sulfasalazine-Induced Ferroptotic Cell Death: Role of Protein Disulfide Isomerase-Mediated NOS Activation and NO Accumulation

ZHU, B.; JIA, Y.; Zhong, J.; Hao, X.

10.1101/2025.04.03.647136 — biochemistry — Posted on 2025-04-08

3757 General Trends in the Calnexin-Dependent Expression and Pharmacological Rescue of Clinical CFTR Variants

Tedman, A.; Olson, J. A.; Kim, M.; Foye, C. C.; Jackson, J.; McDonald, E. F.; McKee, A. G.; Noguera, K.; Kuntz, C. P.; Meiler, J.; Oliver, K. E.; Plate, L.; Schlebach, J. P.

10.1101/2025.04.03.647093 — biochemistry — Posted on 2025-04-08

3758 Conformational Changes of Surfactant Protein B Due to the Alveolar Air/Liquid Interface Using Molecular Dynamics

Locke, T.; Ferrante, A.; Li, D.; Minkara, M.

10.1101/2025.04.06.647458 — biochemistry — Posted on 2025-04-08

3759 AlphaFold3 in Drug Discovery: A Comprehensive Assessment of Capabilities, Limitations, and Applications

Zheng, H.; Wang, J.

10.1101/2025.04.07.647682 — biochemistry — Posted on 2025-04-08

3760 Biosynthesis of Macrocyclic Peptides by Formation and Crosslinking of ortho-Tyrosines

Padhi, C.; Zhu, L.; Chen, J. Y.; Moreira, R.; van der Donk, W. A.

10.1101/2025.04.04.647296 — biochemistry — Posted on 2025-04-08

3761 TUCL-Seq for miRNA single molecule sequencing

Fan, J.; Li, Z.; You, X.; Liu, L.; Jin, H.; Wu, P.; Han, Y.; Sun, L.; Xu, P.; Liu, Y.; Luo, J.; Yan, Q.

10.1101/2025.04.07.646966 — biochemistry — Posted on 2025-04-08

3762 Molecular mechanism for cargo-mediated initiation of kinesin-1 activation

Shukla, S.; Cross, J. A.; Kish, M.; Yadav, S. K.; Weijman, J. F.; O'Regan, L.; Mantell, J.; Borucu, U.; Leng, X.; Schaffitzel, C.; Phillips, J. J.; Woolfson, D. N.; Dodding, M. P.

10.1101/2025.04.08.647705 — biochemistry — Posted on 2025-04-08

3763 A Proposed Statistical Approach for Conducting Longitudinal Assessment of Circulating Tumor DNA

Pretz, C.; Liao, J.; Weipert, C.; Bucheit, L.; Drusbosky, L.; Das, A. K.

10.1101/2025.04.03.646973 — genomics — Posted on 2025-04-08

3764 Decoding RAP1's Role in Yeast mRNA Splicing

Kalra, S.; Coolon, J.

10.1101/2025.04.04.647307 — genomics — Posted on 2025-04-08

3765 Uncovering the molecular basis of high morphinan product efficiency in opium poppy through Multi-omics integrated analysis with multi-capsules

Huang, Y.; Sun, M.; Gong, W.; Liu, Y.; Cheng, Y.; Yuan, L.; Wu, Y.

10.1101/2025.04.03.647041 — genomics — Posted on 2025-04-08

3766 Genetic and functional analysis of unproductive splicing using LeafCutter2

Najar, C. F. B. A.; Feng, R.; Dai, C.; Fair, B.; Hauck, Q.; Li, J.; Cao, X.; Dey, K. K.; De Jager, P.; Bennett, D.; The Alzheimer's Disease Sequencing Project Functional Genomics Consortium, ; Liu, X.; Wang, G.; Li, Y.

10.1101/2025.04.06.646893 — genomics — Posted on 2025-04-08

3767 Insects fight low-dose infections with terminal investment, not innate immunity

Liu, J.; Priest, N. K.

10.1101/2025.04.03.646978 — evolutionary biology — Posted on 2025-04-08

3768 Stochastic Phylogenetic Models of Shape

Stroustrup, S.; Pedersen, M. A.; van der Meulen, F.; Sommer, S.; Nielsen, R.

10.1101/2025.04.03.646616 — evolutionary biology — Posted on 2025-04-08

3769 Episodic Positive Selection Signatures in Arabidopsis CONSTANS-like Genes COL3 and COL5 Indicating Adaptive Evolution in Red-Light Signaling Pathways

Sinha, K.

10.1101/2025.04.03.646976 — evolutionary biology — Posted on 2025-04-08

3770 Flexible Methods for Species Distribution Modeling with Small Samples

Maitner, B. S.; Richards, R. L.; Carlson, B.; Drake, J. M.; Merow, C.

10.1101/2025.04.03.647025 — ecology — Posted on 2025-04-08

3771 Interactions Between Native Soil Microbiome and a Synthetic Microbial Community Reveals Bacteria with Persistent Traits

Velte, J. M.; Mudiyanselage, S. D.; Hofmann, O. F.; Lee, S. T. M.; Huguet-Tapia, J. C.; Miranda, M.; Martins, S. J.

10.1101/2025.04.08.647796 — microbiology — Posted on 2025-04-08

3772 Minimal machine learning models of resistance identify novel antibiotic resistance discovery opportunities in Klebsiella pneumoniae

Parkhill, J.; Collins, C.; Kordova, K.

10.1101/2025.04.08.647753 — microbiology — Posted on 2025-04-08

3773 Cationic antimicrobial copolymers reveal immunomodulatory properties in LPS stimulated macrophages in vitro

Laroque, S.; Harris, J.; Rajendrakumar, S.; Vasilyev, V.; Grewal, J.; Dallmann, R.; Locock, K.; Perrier, S.

10.1101/2025.04.08.647761 — microbiology — Posted on 2025-04-08

3774 Native epitranscriptome sequencing reveals Hepatitis B virus RNA stability protected by heavy m6A modification

Su, P.-Y.; Lin, Y.-H.; Foustine, S.; Chang, C.-H.; Gupta, A.; Papas, B. N.; van der Toorn, W.; von Kleist, M.; Smyth, R.; Morgan, M.; Chen, P.-J.; Tsai, K.

10.1101/2025.04.08.647702 — microbiology — Posted on 2025-04-08

3775 HCV infection induces ubiquitin-dependent degradation of LATS1, inactivating the Hippo pathway and upregulating transcription of the CYR61 and CTGF genes

Septianastiti, M. A.; Matsui, C.; Xu, Z.; Puspitasari, F.; Deng, L.; Abe, T.; Shoji, I.

10.1101/2025.04.08.647823 — microbiology — Posted on 2025-04-08

3776 Differential association of SARS-CoV-2 IgG responses with anti-OC43 IgG in a Senegalese cohort

Faye, R.; Mbow, A. A.; Tall, B.; Gaye, A.; Ndoye, A. M.; Gueye, R.; Diallo, D.; Faye, F. N.; Talla, C.; Dia, N.; Mbengue, B.; Pelleau, S.; Niang, M.; Seydi, M.; Sall, A. A.; Taïeb, F.; Loucoubar, C.; White, M.; Poiret, T.; Vigan-Womas, I.

10.1101/2025.04.07.647508 — immunology — Posted on 2025-04-08

3777 High fat diet but not glucocorticoid-induced obesity results in fatty liver

Agas, A.; Sharma, S.; Narciso, A.; Wilson, J.; Kilkenny, E.; Lantier, L.; Uddin, A.; Patel, R.; McGraw, T.; Teruel, M. N.

10.1101/2025.04.03.647107 — physiology — Posted on 2025-04-08

3778 Dynamic modelling of EWS::FLI1 fluctuations reveals molecular determinants of phenotypic tumor plasticity and prognosis in Ewing sarcoma

Suresh, V.; Hafemeister, C.; Konstantinou, A.; Grissenberger, S.; Sturtzel, C.; Cidre-Aranaz, F.; Wenninger-Weinzierl, A.; Zylka, M.; Queiros, K.; Kurek, D.; Sastre, A.; Alonso, J.; Distel, M.; Obenauf, A.; Gruenewald, T. G. P.; Halbritter, F.; Kovar, H.; Fock, V.

10.1101/2025.04.03.647002 — cancer biology — Posted on 2025-04-08

3779 CIT tumor lines: A novel series of immunogenic squamous cell skin carcinoma cell lines derived from chemical carcinogenesis

Tanaka, M.; Letchworth, R.; Barnes, A. A.; Lum, L.; Hughes, S.; Schlauderaff, G.; Chaudhary, P.; Ng, K. M.; Superville, D.; Martinez Luna, C.; Gonzalez, M.; Grossman, A.; Reeves, M.

10.1101/2025.04.03.647071 — cancer biology — Posted on 2025-04-08

3780 Fano factor as a key measure of sensitivity in biological networks

BANERJEE, K.; Das, B.; Patra, P.

10.1101/2025.04.03.646967 — biophysics — Posted on 2025-04-08

3781 Large-scale conformational analysis explains G-quadruplex topological landscape

Jurkowski, M.; Kogut, M.; Olewniczak, M.; Glinko, J.; Czub, J.

10.1101/2025.04.03.646972 — bioinformatics — Posted on 2025-04-08

3782 REvolutionH-tl: A Fast and Robust Tool for Decoding Evolutionary Gene Histories

Ramirez-Rafael, J. A.; Korchmaros, A.; Avina-Padilla, K.; Lopez-Sanchez, A.; Martinez-Medina, G.; Hernandez-Alvarez, A. J.; Hellmuth, M.; Stadler, P. F.; Hernandez-Rosales, M.

10.1101/2025.04.03.646975 — bioinformatics — Posted on 2025-04-08

3783 Conditional Deep Learning Model Reveals Translation Elongation Determinants during Amino Acid Deprivation

Nallapareddy, M. V.; Craighero, F.; Worpenberg, L.; Naef, F.; Gobet, C.; Vandergheynst, P.

10.1101/2025.04.03.646988 — bioinformatics — Posted on 2025-04-08

3784 PG-SCUnK: measuring pangenome graph representativeness using Single-Copy and Universal K-mers

Cumer, T.; Milia, S.; Leonard, A. S.; Pausch, H.

10.1101/2025.04.03.646777 — bioinformatics — Posted on 2025-04-08

3785 Robust Consensus Nuclear and Cell Segmentation

Irfan, M. O.; Gonzalez-Solares, E. A.; Whitmarsh, T.; Molaeinezhad, A.; Al Sa'd, M.; Mulvey, C. M.; Paez Ribes, M.; Bressan, D.; Walton, N. A.

10.1101/2025.04.03.646876 — bioinformatics — Posted on 2025-04-08

3786 Using Monoids for the Integration of Genomic and Metabolic Parameters in the Prediction of Phenotypes in Regulatory Cascades.

Villalba, M.; Romero, Y.

10.1101/2025.04.03.646970 — bioinformatics — Posted on 2025-04-08

3787 Prolonged autophagy induction correlates with host cell protein reduction in CHO cell culture

Sahoo, A.; Tsukidate, T.; Pendyala, G.; Yang, R.-S.; Li, X.; Madabhushi, S. R.

10.1101/2025.04.03.647032 — bioengineering — Posted on 2025-04-08

3788 Perturbing RNA localization for functional study in neurons

Qi, S.; Han, M.; Fu, M. L.; Zhu, Y.; Choi, A. A.; Li, E.; Bezney, J.; Cai, S.; Miles, L.; Ma, Y.

10.1101/2025.04.05.646707 — bioengineering — Posted on 2025-04-08

3789 Gut Microbe-Derived Trimethylamine Shapes Circadian Rhythms Through the Host Receptor TAAR5

Mahen, K. K.; Massey, W. J.; Orabi, D.; Brown, A. L.; Jaramillo, T. C.; Burrows, A.; Horak, A. J.; Dutta, S.; Mrdjen, M.; Mouannes, N.; Varadharajan, V.; Osborne, L. J.; Ye, X.; Yarbrough, D. M.; Grubb, T.; Zajczenko, N.; Hohe, R.; Banerjee, R.; Linga, P.; Laungani, D.; Hajjar, A.; Sangwan, N.; Dwidar, M.; Buffa, J. A.; Swanson, G. R.; Wang, Z.; Brown, J. M.

10.1101/2025.04.03.647082 — biochemistry — Posted on 2025-04-08

3790 Characterizing mixed single chain amphiphile-based coacervates as a robust protocell system

Patki, G. M.; Sridhar, V.; Rajamani, S.

10.1101/2025.04.05.647343 — biochemistry — Posted on 2025-04-08

3791 Differential activation of NF-κB and HIF-1α between alveolar-like macrophages and myeloid-derived macrophages drive inflammatory differences following Mycobacterium abscessus infection.

Gilliland, H. N.; Soverina, S.; Conner, K. N.; Vielma, T. E.; Olive, A. J.

10.1101/2025.04.03.647026 — immunology — Posted on 2025-04-08

3792 Zebra finch introductory notes do not influence female response to song and juvenile song learning accuracy

Kalra, S.; Chandolia, C.; Gautam, M.; Rajan, R.

10.1101/2025.04.06.647492 — animal behavior and cognition — Posted on 2025-04-08

3793 Bioinformatic discovery of type 11 secretion system (T11SS) cargo across the Proteobacteria

Grossman, A. S.; Mucci, N. C.; Kauffman, S. J.; Rafi, J.; Goodrich-Blair, H.

10.1101/2024.09.26.615229 — microbiology — Posted on 2025-04-08

3794 Cell type-specific enhancers regulate IL-22 expression in innate and adaptive lymphoid cells

Saini, A.; Hopkins, L. S.; Serna, V. A.; McCullen, M. V. D.; Selner, N. G.; Bhattarai, B.; Fachi, J. L.; Glynn, R.; Hayer, K. E.; Bassing, C. H.; Colonna, M.; Oltz, E. M.

10.1101/2025.04.02.646834 — immunology — Posted on 2025-04-08

3795 Chemical representation standardization needed to generalize metabolic pathway involvement prediction across the Kyoto Encyclopedia of Genes and Genomes, Reactome, and MetaCyc knowledgebases

Huckvale, E. D.; Moseley, H. N. B.

10.1101/2025.04.02.646918 — systems biology — Posted on 2025-04-08

3796 Partial cross-resistance of oats to different Fusarium species and the role of trichomes in susceptibility

Schurack, S.; Rodemann, C.; Oldach, K.; Beuch, S.; Brodfuehrer, S.; von Tiedemann, A.; Herrmann, M. H.

10.1101/2025.04.08.647721 — plant biology — Posted on 2025-04-08

3797 The non-steroidal mineralocorticoid receptor (MR) antagonist (FINERENONE) reverses Western diet-induced kidney disease by enhancing mitochondrial metabolism and decreasing lipid accumulation and inflammation

Myakala, K.; Wang, X. X.; Shults, N. V.; Hughes, E.; Ribeiro, P. d. C.; Penjweini, R.; Link, K.; Barton, K.; Jones, B. A.; Krawczyk, E.; Clarkson-Paredes, C.; Popratiloff, A.; Knutson, J. R.; cowart, l. a.; Levi, M.

10.1101/2025.04.02.646892 — pharmacology and toxicology — Posted on 2025-04-08

3798 Injury-induced electrochemical coupling triggers regenerative cell proliferation

Liu, J.; Nerli, E.; Duclut, C.; Vishen, A. S.; Berbee, N.; Kaufmann, S.; Ponce, C.; Arrenberg, A. B.; Julicher, F.; Mateus, R.

10.1101/2025.04.03.647033 — biophysics — Posted on 2025-04-08

3799 Single-Cell Multiomic Analysis of Circadian Rhythmicity in Mouse Liver

Tong, C. Y.; Li, C.; Hurni, C.; Jacq, A.; Nie, X. Y.; Guy, C. R.; Suh, J. H.; Wong, R. K. W.; Merlin, C.; Naef, F.; Menet, J. S.; Jiang, Y.

10.1101/2025.04.03.647044 — bioinformatics — Posted on 2025-04-08

3800 Metric Validation for Detection of Delayed and Directed Coupling

Dembny, K.; Farooqi, H.; Herman, A. B.; Netoff, T. I.; Darrow, D. P.

10.1101/2025.04.02.646886 — bioinformatics — Posted on 2025-04-08

3801 Physicochemical and microbiome changes in queso crema de Chiapas during ripening

Ocampo Morales, B. N.; Hernandez Montes, A.; Estrada, K.; Valadez Moctezuma, E.

10.1101/2025.04.02.646936 — bioinformatics — Posted on 2025-04-08

3802 ATOMICA: Learning Universal Representations of Intermolecular Interactions

Fang, A.; Zhang, Z.; Zhou, A.; Zitnik, M.

10.1101/2025.04.02.646906 — bioinformatics — Posted on 2025-04-08

3803 Method for Extracellular Electrochemical Impedance Spectroscopy on Epithelia

Chien, A. J.; Lewallen, C. F.; Khor, H.; Vazquez Cegla, A.; Guo, R.; McCarty, N. A.; Bharti, K.; Forest, C. R.

10.1101/2025.04.02.646694 — bioengineering — Posted on 2025-04-08

3804 Extracellular loops of the β-barrel domain catalyze rapid folding for function of self-associating autotransporters

Yuan, X.; Johnson, M. D.; Long, J.; Zhang, J.; Lo, A. W.; Paxman, J. J.; Phan, D.; Heras, B.; Schembri, M. A.; Huysmans, G. H. M.; Henderson, I. R.; Doyle, M. T.; Leyton, D. L.

10.1101/2025.04.08.647479 — biochemistry — Posted on 2025-04-08

3805 The genome sequence of the hemlock woolly adelgid, Adelges tsugae Annand 1924

Brunet, B. M. T.; Dial, D. T.; Burke, G. R.; von Dohlen, C. D.; Freitas, J. D.; Sanderson, H.; Chida, A. R.; Jones, S. J.; Martin, F. J.; Haggerty, L.; Scherer, S. W.; Ragoussis, I.; Jones, S. J. M.; Foottit, R. G.; Havill, N. P.

10.1101/2025.04.07.644581 — genomics — Posted on 2025-04-08

3806 Genome-wide association study reveals candidate loci for resistance to anthracnose in blueberry

Ghimire, L.; Adunola, P.; Harmon, P. F.; Azevedo, C. F.; Schultz, T. J.; Leme, B.; Enciso-Rodriguez, F. E.; Benevenuto, J.; Ferrao, L. F. V.; Munoz, P. R.

10.1101/2025.04.02.646913 — genomics — Posted on 2025-04-08

3807 Stable encoding of the natural variability of a dexterous motor skill in the cortex of freely behaving mice

de Laittre, E. A.; MacLean, J. N.

10.1101/2024.12.20.629771 — neuroscience — Posted on 2025-04-08

3808 The Diabetes Gene Tcf7l2 Organizes Gene Expression in the Liver and Regulates Amino Acid Metabolism

Krawczyk, J.; O'Connor, W.; Vendramini, P.; Schell, M.; Biddinger, K. J.; Pengo, G.; Fougeray, T.; Aragam, K. G.; Haigis, M. C.; Lamers, W. H.; Tsai, L.; Biddinger, S.

10.1101/2025.04.03.647067 — physiology — Posted on 2025-04-08

3809 PRMT1-Mediated Metabolic Reprogramming Promotes Leukemogenesis

Su, H.; Sun, Y.; Guo, H.; Sun, C.-w.; Chen, Q.; Liu, S.; Li, A.; Gao, M.; Zhao, R.; Raffel, G.; Jin, J.; Qu, C.-K.; Yu, M.; Klug, C. A.; Zheng, Y. G.; Ballinger, S.; Kutny, M.; Long Zheng, X.; Chong, Z.; Senevirathne, C.; Gross, S.; Chen, Y.; Luo, M.; Zhao, X.

10.1101/2024.12.12.628174 — cancer biology — Posted on 2025-04-08

3810 Label-free Imaging of the Reversible Rhodopsin Dynamics in a Living Eye

Zhuo, Y.; Li, H.; Bhuckory, M. B.; Pham-Howard, D.; Palanker, D.

10.1101/2025.04.02.646910 — bioengineering — Posted on 2025-04-08

3811 Alpha-synuclein amyloids catalyze the degradation of ATP and other nucleotides

Castillo-Caceres, C.; Nova, E.; Diaz-Espinoza, R.

10.1101/2025.04.03.647058 — biochemistry — Posted on 2025-04-08

3812 STRIPAK complex defects result in pseudosexual reproduction in Cryptococcus neoformans

Peterson, P. P.; Croog, S.; Choi, Y.; Sun, S.; Heitman, J.

10.1101/2025.04.08.647827 — genetics — Posted on 2025-04-08

3813 Interpreting SNP heritability in admixed populations

Huang, J.; Kleman, N.; Basu, S.; Shriver, M. D.; Zaidi, A. A.

10.1101/2023.08.04.551959 — genetics — Posted on 2025-04-08

3814 Plant silicon defence disrupts cryptic colouration in an insect herbivore by restricting carotenoid sequestration into the haemolymph

Islam, T.; Anwar, S.; Cazzonelli, C. I.; Moore, B. D.; Johnson, S. N.

10.1101/2025.04.02.646851 — ecology — Posted on 2025-04-08

3815 Molecular signature and functional properties of human pluripotent stem cell-derived brain pericytes

Rust, R.; Bosworth, A.; Sagare, A. P.; Kisler, K.; Kim, Y.; Zhang, M.; Griffin, C.; Wang, Y.; Clementel, V.; Torres-Sepulveda, C.; TCW, J.; Zlokovic, B.; Coba, M.

10.1101/2023.06.26.546577 — neuroscience — Posted on 2025-04-08

3816 Neural dynamics of visual working memory representation during sensory distraction

Degutis, J. K.; Weber, S.; Soch, J.; Haynes, J.-D.

10.1101/2024.04.12.589170 — neuroscience — Posted on 2025-04-08

3817 A cross-species analysis of neuroanatomical covariance sex differences in humans and mice

Pham, L.; Guma, E.; Ellegood, J.; Lerch, J. P.; Raznahan, A.

10.1101/2024.11.05.622111 — neuroscience — Posted on 2025-04-08

3818 The heartbeat-evoked potential in young and older adults during attention orienting

Aprile, F.; Simoes, M.; Henriques, J.; de Carvalho, P.; Castelo-Branco, M.; Sel, A.; Ribeiro, M. J.

10.1101/2024.01.31.578137 — neuroscience — Posted on 2025-04-08

3819 Novel strains of tomato spotted wilt orthotospovirus (TSWV) are transmitted by western flower thrips in a context-specific manner

Chinnaiah, S.; Arora, A. K.; Gadhave, K.

10.1101/2025.04.02.646938 — zoology — Posted on 2025-04-08

3820 Lipidomics Reveals Cell Specific Changes During Pluripotent Differentiation to Neural and Mesodermal Lineages

Odenkirk, M. T.; Jostes, H. C.; Francis, K. R.; Baker, E. S.

10.1101/2024.12.31.630916 — systems biology — Posted on 2025-04-08

3821 ALFIN-LIKE Proteins Orchestrate H3K4me3-H3K27me3 Crosstalk to Regulate Plant Embryogenesis

Scotton, J.; Fu, Y.; Tourdot, E.; Schmid, M. W.; Simonini, S.

10.1101/2025.04.08.647773 — plant biology — Posted on 2025-04-08

3822 Relaxin signaling is critical for virgin female reproductive physiology in Drosophila

Volonte, Y.; Heredia, F.; Zanini, R.; Menezes, J.; Perez, M. S.; Gualdino, M.; Lage, L.; Cruz, L. d. S.; Casimiro, A. P.; Garelli, A.; Gontijo, A. M.

10.1101/2025.04.03.647069 — physiology — Posted on 2025-04-08

3823 Synergistic Antitumor Activity of SUMO1 degrader and Oxaliplatin through G6PD Inhibition in Colorectal Cancer

Jung, S.; Roy, R.; Zhao, Y. Q.; OConnell, T. M.; Wohlford, R. K.; Kim, D.; Hao, C.; Bellail, A.

10.1101/2025.04.08.647644 — cancer biology — Posted on 2025-04-08

3824 A systematic assessment of single-cell language model configurations

De Waele, G.; Menschaert, G.; Waegeman, W.

10.1101/2025.04.02.646825 — bioinformatics — Posted on 2025-04-08

3825 Methods for Quantitative Analyses of Nerve Fiber Deformation in the Myenteric Plexus Under Loading of Mouse Distal Colon and Rectum

Shokrani, A.; Seck, A.; Feng, B.; Pierce, D. M.

10.1101/2025.04.02.646858 — bioengineering — Posted on 2025-04-08

3826 Colorectum and Embedded Networks of Nerve Fibers Present Auxetic Responses During Uniaxial Circumferential Extension

Shokrani, A.; Seck, A.; Hoshino, K.; Feng, B.; Pierce, D. M.

10.1101/2025.04.02.646859 — bioengineering — Posted on 2025-04-08

3827 A combination of Mechanical, Chemical, and Thermal Pretreatments of Agricultural Feedstocks Enhances Biomethane Yields in Advanced Anaerobic Digestion

Austen, N.; Theaker, H.; Tenci, N. A.; Beesley, A.; Thompson, I. P.

10.1101/2025.04.02.646888 — bioengineering — Posted on 2025-04-08

3828 Independent Validation of Transgenerational Inheritance of Learned Pathogen Avoidance in Caenorhabditis elegans

Akinosho, A.; Alexander, J.; Floyd, K.; Vidal-Gadea, A.

10.1101/2025.04.03.647070 — genetics — Posted on 2025-04-08

3829 Evolution of gene order in prokaryotes is driven primarily by gene gain and loss

Brezner, S.; Garushyants, S. K.; Wolf, Y. I.; Koonin, E.; Snir, S.

10.1101/2025.04.03.647019 — evolutionary biology — Posted on 2025-04-08

3830 Unraveling CRP/cAMP-Mediated Metabolic Regulation In Escherichia coli Persister Cells

Ngo, H. G.; Mohiuddin, S. G.; Ananda, A.; Orman, M.

10.1101/2024.06.10.598332 — microbiology — Posted on 2025-04-08

3831 Striated fibre assemblins localise in the feeding groove of the 'typical excavate' Paratrimastix pyriformis

Heiss, A. A.; Fang, Y.-K.; Konupkova, A.; Zitek, J.; Novak, J.; Smida, A.; Zelena, M.; Svagr, E.; Miksatko, J.; Liebl, D.; Pena-Diaz, P.; Hampl, V.

10.1101/2024.03.29.587336 — microbiology — Posted on 2025-04-08

3832 B cell repertoire of children with atopic dermatitis exhibit altered IgE maturationassociated with allergic food sensitization

Gill, K.; Moore, C.; Nwogu, O.; Kroner, J. W.; Chang, W.-C.; Burkle, J.; Virolainen, S. J.; Stevens, M. L.; Baatyrbek kyzy, A.; Miraldi, E.; Biagini, J.; Devonshire, A. L.; Kottyan, L.; Schwartz, J. T.; Assa'ad, A.; Martin, L. J.; Andorf, S.; Hershey, G. K.; Roskin, K. M.

10.1101/2023.02.01.526538 — immunology — Posted on 2025-04-08

3833 Frequency-Specific Resting-State MEG Network Characteristics of Tinnitus Patients Revealed by Graph Learning

Sadeghi Shabestari, P.; Behjat, H. H.; Van De Ville, D.; Cederroth, C. R.; Edvall, N. K.; Naas, A.; Kleinjung, T.; Neff, P.

10.1101/2025.03.10.642147 — neuroscience — Posted on 2025-04-08

3834 Streptomyces coelicolor-plant association facilitates ergothioneine (EGT) uptake in Triticum aestivum

Pipinos, A.; Kan, J.; Smith, A.; Zinati, G.; Bais, H.

10.1101/2025.04.08.647769 — plant biology — Posted on 2025-04-08

3835 Comparative analysis of centromeres of oat (Avena sativa) and its tetraploid and diploid relatives reveals rapid evolution of centromere composition and architecture

Wehrkamp, C. M.; Heuberger, M.; Wicker, T.

10.1101/2025.04.08.647780 — plant biology — Posted on 2025-04-08

3836 Elucidating tissue and sub-cellular specificity of the entire SUMO network reveals how stress responses are fine-tuned in a eukaryote

Sadanandom, A.; Banda, J.; Ghosh, S.; Roy, D.; Bishopp, A.; Jones, A.; Sharma, E.; Sue-Ob, K.; Clark, L.; Band, L. R.; Lilley, K. S.; Bennett, M. J.; Ingole, K.; De Lucas, M.; Bhosale, R.

10.1101/2025.04.08.647708 — plant biology — Posted on 2025-04-08

3837 Historic transposon mobilisation waves create distinct pools of adaptive variants in a major crop pathogen

Baril, T. J.; Puccetti, G.; Croll, D.

10.1101/2025.04.02.646807 — genomics — Posted on 2025-04-08

3838 Leveraging foundation models to dissect the genetic basis of cluster compactness and yield in grapevine

Sharma, S.; Munoz, J.; Torres-Lomas, E.; Lin, J.; Banayad, H.; Lupo, Y.; Nunez, V.; Gaspar, A.; Cantu, D.; Diaz-Garcia, L.

10.1101/2025.04.02.646891 — genetics — Posted on 2025-04-08

3839 Evidence for balancing selection on loci associated with host use in the genome of a generalist plant parasite

Calvert, M.; Wu, L.; Chen, A.; Gupta, A.; Wood, C. W.

10.1101/2025.04.02.646902 — evolutionary biology — Posted on 2025-04-08

3840 The impact of artificial linear features on the pollination of plant communities

Li, D.; Clements, C. F.; Memmott, J.

10.1101/2025.04.02.646872 — ecology — Posted on 2025-04-08

3841 Th1 cells express Tfh effector molecules and associate with B cells at the T-B borderfollowing viral infection

Chen, J. S.; Tierney, A. L.; Ojo, O. A.; Chow, R. D.; Song, E.; Mao, T.; Israelow, B.; Weinstein, J. S.; Williams, A.; Wilen, C. B.; Eisenbarth, S. C.

10.1101/2025.04.02.646697 — immunology — Posted on 2025-04-08

3842 Data-driven mathematical modelling explains altered timing of EARLY FLOWERING 3 in the wheat circadian oscillator

Upadhyay, A.; Rowland-Chandler, J.; Stewart-Wood, J.; Pingarron-Cardenas, G.; Tokuda, I. T.; Webb, A. A.; Locke, J. C.

10.1101/2025.04.08.644541 — plant biology — Posted on 2025-04-08

3843 Reconstruction and exploitation of a dedicated Genome-Scale Metabolic Model of the human pathogen C. neoformans

Viana, R.; Couceiro, D.; Newton, W.; Coutinho, L.; Dias, O. C.; Coelho, C.; Teixeira, M. C.

10.1101/2025.04.02.646762 — bioinformatics — Posted on 2025-04-08

3844 Quartformer: An Accurate Deep LearningFramework for Phylogenetic TreeConstruction

Junyv, S.; Xiyun, J.

10.1101/2025.04.05.646867 — bioinformatics — Posted on 2025-04-08

3845 A modular, Galaxy-based immunopeptidogenomic (iPepGen) analysis pipeline for discovery, verification, and prioritization of candidate cancer neoantigen peptides

Mehta, S.; Wagner, R.; Do, K. T.; Johnson, J. E.; Yu, F.; Jubenville, T.; Richards, K.; Coleman, S.; Popescu, F. E.; Nesvizhskii, A. I.; Largaespada, D. A.; Jagtap, P. D.; Griffin, T. J.

10.1101/2025.04.07.647596 — bioinformatics — Posted on 2025-04-08

3846 High-resolution reconstruction of cell-type specific transcriptional regulatory processes from bulk sequencing samples

Yao, L.; Shah, S. R.; Ozer, A.; Zhang, J.; Pan, X.; Xia, T.; Fangal, V.; Leung, A. K.-Y.; Wei, M.; Lis, J.; Yu, H.

10.1101/2025.04.02.646189 — bioinformatics — Posted on 2025-04-08

3847 AdapToR: Adaptive Topological Regression for quantitative structure-activity relationship modeling

Mao, Y.; Ghosh, S.; Pal, R.

10.1101/2025.04.02.646801 — bioinformatics — Posted on 2025-04-08

3848 Breaking the barrier of human-annotated training data for machine-learning-aided plant research using aerial imagery

Varela, S.; Zheng, X.; Njuguna, J.; Sacks, E.; Allen, D.; Ruhter, J.; Leakey, A.

10.1101/2025.04.02.646808 — bioinformatics — Posted on 2025-04-08

3849 RAINSTORM: Automated Behavioral Analysis for Mice Exploratory Behavior Using Artificial Neural Networks.

D'hers, S.; Robles, A. D.; Ojea Ramos, S.; Bollini, G. M.; Feld, M.

10.1101/2025.04.07.647548 — animal behavior and cognition — Posted on 2025-04-08

3850 Prolonged visual deprivation in adults induces non-homeostatic plasticity of feed-forward excitation from visual thalamus to cortex

Murase, S.; Severin, D.; Dye, L.; Mesik, L.; Moreno, C.; kirkwood, a.; Quinlan, E. M.

10.1101/2024.12.04.626829 — neuroscience — Posted on 2025-04-08

3851 RAG-ESM: Improving pretrained protein language models via sequence retrieval

Sgarbossa, D.; Bitbol, A.-F.

10.1101/2025.04.02.646805 — bioinformatics — Posted on 2025-04-08

3852 Nuc3DMap delineates finer nucleosome-based three-dimensional chromatin architecture

Fang, K.; Choppavarapu, L.; Liu, T.; Knight, P. A.; Jin, V. X.

10.1101/2025.04.03.647017 — bioinformatics — Posted on 2025-04-08

3853 Non-invasive skin topical delivery of hyaluronan

Feng, W.; Ye, J.; Li, S.; Shao, S.; Xiang, J.; Piao, Y.; Wei, Q.; Tang, J.; Zhou, Z.; Shen, Y.

10.1101/2025.04.03.646962 — bioengineering — Posted on 2025-04-08

3854 Evaluation of adipose-derived stromal cell infused modified-hyaluronic acid scaffolds for post cancer breast reconstruction

Challapalli, R. S.; O'Dwyer, J.; McInerney, N.; Kerin, M. J.; Duffy, G. P.; Dolan, E. B.; Dwyer, R. M.; Lowery, A. J.

10.1101/2025.04.03.646623 — bioengineering — Posted on 2025-04-08

3855 Transient optical clearing using absorbing molecules for ex-vivo and in-vivo imaging

Shabbir, M. W.; Phillips, M.; Asante-Asare, D.; Ou, Z.

10.1101/2025.04.02.646849 — bioengineering — Posted on 2025-04-08

3856 Methods for simulations with thousands of interacting objects to model mass transport in the brain

Elbert, D. L.; Esguerra, D. P.

10.1101/2025.04.03.647052 — bioengineering — Posted on 2025-04-08

3857 A new framework for analyzing mass transport in cortical brain tissue at <10 nm resolution

Elbert, D. L.; Esguerra, D. P.

10.1101/2025.04.02.646802 — bioengineering — Posted on 2025-04-08

3858 Behavioral effects of targeting the central thalamus and pulvinar with transcranial ultrasound stimulation in healthy volunteers

Hopkins, A. R.; Cain, J. A.; White, E. A.; Abakians, S.; Monti, M. M.

10.1101/2025.02.27.640692 — neuroscience — Posted on 2025-04-08

3859 Consequences of resource constraint on stochastic gene regulation

Solanki, U. S.; Singh, A.; Patel, A.

10.1101/2025.04.02.646804 — systems biology — Posted on 2025-04-08

3860 DILP8 serves as a mature follicle sensor to prevent excessive accumulation of maturefollicles in Drosophila ovaries and oocyte aging.

Oramas, R.; Yacuk, K.; Cho, S. E.; Aloisio, N. R.; Sun, J.

10.1101/2025.04.02.646814 — physiology — Posted on 2025-04-08

3861 MRS-Sim: Open-Source Framework for Simulating Realistic In Vivo-like MR Spectroscopy Data

LaMaster, J. T.; Oeltzschner, G.; Li, Y.

10.1101/2024.12.20.629645 — bioengineering — Posted on 2025-04-08

3862 A gene-based model of fitness and its implications for genetic variation: Linkage disequilibrium

Johri, P.; Charlesworth, B.

10.1101/2024.09.12.612686 — evolutionary biology — Posted on 2025-04-08

3863 A gene-based model of fitness and its implications for genetic variation: Genetic and inbreeding loads

Johri, P.; Charlesworth, B.

10.1101/2025.02.19.639162 — evolutionary biology — Posted on 2025-04-08

3864 Newly Sequenced Genomes Reveal Patterns of Gene Family Expansion in select Dragonflies (Odonata: Anisoptera)

Tolman, E. R.; Beatty, C. D.; Frandsen, P. B.; Bush, R. J.; Burchim, O. R.; Driever, E. S.; Harding, K. M.; Jordan, D.; Kohli, M. K.; Park, J.; Park, S.; Reyes, K.; Rosario, M.; Ryu, J. L.; Wade, V.; Ware, J. L.; Suvorov, A.

10.1101/2023.12.11.569651 — evolutionary biology — Posted on 2025-04-08

3865 The integration mechanism of the four positional cues--anterior, posterior, dorsal, and ventral--in axolotl limb regeneration

Yamamoto, S.; Furukawa, S.; Ohashi, A.; Hamada, M.; Satoh, A.

10.1101/2025.04.07.647593 — developmental biology — Posted on 2025-04-08

3866 The DNA damage response and RNA Polymerase II regulator Def1 has posttranscriptional functions in the cytoplasm

Akinniyi, O. T.; Sebastian, A.; Kulkarni, S.; Hribal, M. M.; Keller, C. A.; Giardine, B.; Albert, I.; Reese, J. C.

10.1101/2024.09.16.613278 — molecular biology — Posted on 2025-04-08

3867 Evolutionary plasticity of bacterial surface layer protein exoskeletons

Barwinska-Sendra, A.; Salgado, P. S.; Sendra, K. M.

10.1101/2025.04.02.646754 — microbiology — Posted on 2025-04-08

3868 Mobile genetic elements that shape microbial diversity and functions in thawing permafrost soils

Guo, J.; Aroney, S.; Dominguez-Huerta, G.; Smith, D.; Vik, D.; Ansah, C. O.; Pratama, A. A.; Solonenko, S.; Tian, F.; Howard-Varona, C.; Zhong, Z.; Fofana, A.; Smith, G.; Hodgkins, S. B.; Cronin, D.; EMERGE Field Teams 2010-2019, ; EMERGE Coordinators, ; Woodcroft, B. J.; Tyson, G. W.; Rich, V. I.; Sullivan, M. B.; Roux, S.; Bagby, S. C.

10.1101/2025.02.12.637893 — microbiology — Posted on 2025-04-08

3869 Regulatory T cell stability determines the efficiency of bile duct regeneration during cholangitis.

Kimura, N.; Wong, M. C.; Hardisty, G.; Higgins, B.; Huang, P.-C.; Besh, M.; Kendall, T. J.; Rossi, A.; Ramachandran, P.; Patten, D.; Shetty, S.; Anderson, G.; Withers, D.; Tsuchiya, A.; Terai, S.; Lu, W.-Y.

10.1101/2025.04.02.646748 — immunology — Posted on 2025-04-08

3870 Open-source Photobleacher for Fluorescent Imaging of Large Pigment-Rich Tissues

Murakami, T. C.; Belenko, N.; Dennis, G.; Wang, C.; Siantoputri, M. E.; Maeda, Y.; Pressl, C.; Heintz, N.

10.1101/2025.02.24.639965 — neuroscience — Posted on 2025-04-08

3871 Cardiorespiratory fitness and cardiometabolic health are associated with distinct cognitive domains in cognitively healthy older adults.

Kałamała, P.; Ware, N.; Fabiani, M.; Michie, P. T.; Hunter, M.; Wade, A.; Simpson, F.; Mellow, M. L.; Low, K.; Keage, H.; Gratton, G.; Smith, A. E.; Karayanidis, F.

10.1101/2025.04.06.646611 — neuroscience — Posted on 2025-04-08

3872 Molecular characterization of gustatory second-order neurons reveals integrative mechanisms of gustatory and metabolic information

Molla-Albaladejo, R.; Jimenez-Caballero, M.; Sanchez-Alcaniz, J. A.

10.1101/2024.06.17.598832 — neuroscience — Posted on 2025-04-08

3873 Organ-level Gene Regulatory Network models enable the identification of central transcription factors in Solanum lycopersicum

Fernandez, J. D.; Navarro-Paya, D.; Santiago, A.; Cerda, A.; Canan, J.; Contreras-Riquelme, S.; Moyano, T. C.; Melet, L.; Johnson, N. R.; Alvarez, J. M.; Canales, J.; Matus, J. T.; Vidal, E. A.

10.1101/2025.03.26.645553 — systems biology — Posted on 2025-04-08

3874 A leaf phenomics approach to estimating below-ground traits in North American Licorice

Harris, Z. N.; Tran, V.; Piotter, E.; Hanlon, M. T.; Rubin, M. J.; Miller, A. J.

10.1101/2025.04.07.647639 — plant biology — Posted on 2025-04-08

3875 A network of RS splicing regulatory proteins controls light-dependent splicing and seedling development

Saile, J.; Walter, H.; Denecke, M.; Lederer, P.; Schuetz, L.; Hiltbrunner, A.; Lepp, K.; Lobato-Gil, S.; Beli, P.; Wachter, A.

10.1101/2025.04.07.646831 — plant biology — Posted on 2025-04-08

3876 Robust non-invasive detection of hyperglycemia in mouse models of metabolic dysregulation: the novel Urination Index biomarker

Brachs, S.; Dall, M.; Zimbalski, L.-K.; Santin, Y.; Oeing, C.; Mai, K.; Parini, A.; Gaburro, S.; Nielsen, T. S.

10.1101/2025.04.02.646666 — physiology — Posted on 2025-04-08

3877 SPAC: a scalable, integrated enterprise platform for end-to-end single cell spatial analysis of multiplexed tissue imaging

Liu, F.; He, R.; Sheeley, T.; Scheiblin, D.; Lockett, S. J.; Ridnour, L. A.; Wink, D. A.; Jensen, M.; Cortner, J.; Zaki, G.

10.1101/2025.04.02.646782 — bioinformatics — Posted on 2025-04-08

3878 RNAcompare: Integrating machine learning algorithms to unveil the similarities of phenotypes based on clinical, multi-omics using Rheumatoid Arthritis and Heart Failure as Case Studies

Tang, M.

10.1101/2025.04.02.646760 — bioinformatics — Posted on 2025-04-08

3879 Modeling viral and bacterial infections in human lung organotypic systems reveals strain specific host responses

Faria Fonseca, B.; Wong-Ng, J.; Connor, M.; Mary, H.; Kim, M. H.; Yim, R.; BONDET, V.; Michel, V.; Strick Marchand, H.; Di Santo, J. P.; Duffy, D.; Hamon, M. A.; Sauvonnet, N.; Chakrabarti, L. A.; Gobaa, S.

10.1101/2025.03.31.644992 — bioengineering — Posted on 2025-04-08

3880 Beyond the known cuts: trypsin specificity in native proteins

Gaspar, M.; Sokolova, B.; Saei, A.; Marques, J. C.; Zubarev, R. A.

10.1101/2025.04.04.647035 — biochemistry — Posted on 2025-04-08

3881 BromoCatch: a self-labelling tag platform for protein analysis and live cell imaging

Rodriguez-Rios, M.; Craigon, C. G.; Nakasone, M. A.; Bond, A. G.; Dorward, M.; Edmonds, A. K.; Norley, M. C.; Arnold, R. E.; Wood, P. M.; Reynolds, S. J.; Cresser-Brown, J. O.; Marsh, G. P.; Maple, H. J.; Ciulli, A.

10.1101/2025.04.07.647551 — biochemistry — Posted on 2025-04-08

3882 Motivational trade-offs as evidence for sentience in bees: a critique

Read, J.; Nityananda, V.

10.1101/2025.04.04.647054 — animal behavior and cognition — Posted on 2025-04-08

3883 Comparative analysis of mammalian adaptive immune loci revealed spectacular divergence and common genetic patterns

Pospelova, M.; Voss, K.; Zamyatin, A.; Watson, C. T.; Koepfli, K.-P.; Bankevich, A.; Pennell, M.; Safonova, Y.

10.1101/2025.04.01.646651 — genomics — Posted on 2025-04-08

3884 Molecular Requirements for C. elegans Transgenerational Epigenetic Inheritance of Pathogen Avoidance

Kaletsky, R.; Moore, R. S.; Sengupta, T.; Seto, R.; Llera, B. C.; Murphy, C. T.

10.1101/2025.01.21.634111 — genetics — Posted on 2025-04-08

3885 Mapping fitness landscapes to interpret sex allocation in hermaphrodites

Chen, K.-H.; Pannell, J. R.

10.1101/2024.07.23.604733 — evolutionary biology — Posted on 2025-04-08

3886 Host and antibiotic jointly select for greater virulence in Staphylococcus aureus

Su, M.; Hoang, K.; Penley, M.; Davis, M.; Gresham, J.; Morran, L.; Read, T.

10.1101/2024.08.31.610628 — evolutionary biology — Posted on 2025-04-08

3887 Novel hyperplastic expansion of white adipose tissue underlies the metabolically healthy obese phenotype of male LFABP null mice

Diolintzi, A.; Zhou, Y.; Fomina, A.; Husain, S.; Sidossis, L. S.; Fried, S. K.; Storch, J.

10.1101/2025.04.07.647661 — cell biology — Posted on 2025-04-08

3888 Inhibition and Updating Share Common Resources: Bayesian Evidence from Signal Detection Theory and Drift Diffusion Model

Sun, Y.; Lin, Y.; Han, S.

10.1101/2024.11.06.622265 — neuroscience — Posted on 2025-04-08

3889 A novel critic signal in identified midbrain dopaminergic neurons of mice training in operant tasks

Matsumoto, J.; Oberto, V.; Pompili, M. N.; Todorova, R.; Papaleo, F.; Nishijo, H.; Venance, L.; Vandecasteele, M.; Wiener, S. I.

10.1101/2024.05.06.592735 — neuroscience — Posted on 2025-04-08

3890 Differential Effects of Short-term and Long-term Deep Brain Stimulation on Striatal Neuronal Excitability in a Dystonia Animal Model

Heerdegen, M.; Franz, D.; Neubert, V.; Kragelund, F.; Sellmann, T.; Werner-Schmolling, C.; Starke, J.; Spiliotis, K.; Richter, F. A.; Richter, A.; Kohling, R.

10.1101/2025.04.07.647541 — neuroscience — Posted on 2025-04-08

3891 Mapping grey and white matter activity in the human brain with isotropic ADC-fMRI

Spencer, A. P. C.; Nguyen-Duc, J.; de Riedmatten, I.; Szczepankiewicz, F.; Jelescu, I. O.

10.1101/2024.10.01.615823 — neuroscience — Posted on 2025-04-08

3892 Dependence of higher-order correlations and information compression on temporal resolution in neuronal data

Jangjoo, F.

10.1101/2025.03.23.644813 — neuroscience — Posted on 2025-04-08

3893 Estimating the replicability of Brazilian biomedical science

10.1101/2025.04.02.645026 — scientific communication and education — Posted on 2025-04-08

3894 Semilichen - an unjustly neglected symbiotic system between green biofilms and true lichens

Vondrak, J.; Svoboda, S.; Riha, P.; Hauser, T.; Kantnerova, V.; Skaloud, P.; Kubasek, J.

10.1101/2024.12.10.626781 — physiology — Posted on 2025-04-08

3895 Primulagenin A is a potent inverse agonist of the nuclear receptor RAR-related orphan receptor gamma (RORγ)

Schwarz, P. F.; Perhal, A. F.; Preglej, T.; Breit, L.; Schmetterer, K. G.; Grienke, U.; Janneschütz, J.; Chen, Y.; Rochel, N.; Kirchmair, J.; Schützenmeister, N.; Rollinger, J. M.; Bonelli, M.; Dirsch, V. M.

10.1101/2025.04.01.646598 — pharmacology and toxicology — Posted on 2025-04-08

3896 RNAhub - an automated pipeline to search and align RNA homologs with secondary structure assessment

Magnus, M.; Gao, W.; Dutta, N.; Vicens, Q.; Rivas, E.

10.1101/2025.03.11.642701 — bioinformatics — Posted on 2025-04-08

3897 All-at-once RNA folding with 3D motif prediction framed by evolutionary information

Karan, A.; Rivas, E.

10.1101/2024.12.17.628809 — bioinformatics — Posted on 2025-04-08

3898 Dioecy in a wind-pollinated herb explained by disruptive selection on sex allocation

Chen, K.-H.; Pannell, J. R.

10.1101/2025.01.07.631798 — evolutionary biology — Posted on 2025-04-08

3899 PLCg2 Controls Neutrophil Sensitivity through Calcium Oscillation and Gates Chemoattractant Concentration Range for Chemotaxis

xu, x.; Lee, A.; jin, t.; kim, w. s.

10.1101/2025.04.07.647573 — cell biology — Posted on 2025-04-08

3900 Distinct yet Overlapping Functions of VMP1 and TMEM41B in Modulating Hepatic Lipoprotein Secretion and Autophagy in MASH

Chen, A.; Nguyen, K.; Jiang, X.; Yu, X.; Xie, Y.; Liu, W.; Davidson, N.; Ding, W.-X.; Ni, H.-M.

10.1101/2025.04.07.647617 — cell biology — Posted on 2025-04-08

3901 Isolation and primary culture of Octopus vulgaris cells: Assessment of their proliferative capacity

Galindo, A.; Coello, R.; Banos, I.; Ramos-Trujillo, E.; Morales, A.; Arrieta, J. M.; Rodriguez, C.; Almansa, E.

10.1101/2025.04.07.647602 — cell biology — Posted on 2025-04-08

3902 Using 3D Invasion properties of RCC Cell Lines In Vitro to predict their Metastatic Potential In Vivo

Cesana, B.; Nemoz-Billet, L.; Azemard, V.; Pillet, C.; Bigot, E.; Chaumontel, N.; Descotes, J.-L.; OSMANI, O.; GOETZ, J. G.; Cochet, C.; Filhol, O.

10.1101/2025.04.07.647527 — cell biology — Posted on 2025-04-08

3903 Inactivation of CDK4/6, CDK2, and ERK in G1-phase triggers differentiation commitment

Sharma, S.; Berger, H.; Meyer, T.; Teruel, M. N.

10.1101/2025.04.07.647597 — cell biology — Posted on 2025-04-08

3904 AMPK is dispensable for physiological podocyte and glomerular functions but prevents glomerular fibrosis in experimental diabetes

Srivastava, S. P.; Kopasz-Gemmen, O.; Kunamneni, A.; Thurnman, A.; Ozukan, E.; Swaroop, V.; Yoshida, S.; Hong, S.; Inoki, K.

10.1101/2025.04.07.647592 — cell biology — Posted on 2025-04-08

3905 Step-by-Step Maturation Mechanism of Binary Toxin Pore Revealed by Cryo-EM Analysis

Yamada, T.; Sugita, Y.; Yoshida, T.; Noda, T.; Tsuge, H.

10.1101/2024.10.10.617581 — molecular biology — Posted on 2025-04-08

3906 Synaptic proteome diversity is shaped by the levels of glutamate receptors and their regulatory proteins

Reig-Viader, R.; del Castillo-Berges, D.; Burgas-Pau, A.; Arco-Alonso, D.; Zerpa-Rios, O.; Ramos-Vicente, D.; Picanol, J.; Castellanos, A.; Soto, D.; Roher, N.; Sindreu, C.; Bayes, A.

10.1101/2024.04.04.588090 — neuroscience — Posted on 2025-04-08

3907 A hydrophobic core in the coiled-coil domain is essential for NRC resistosome function

Wang, H.-Y.; Yuen, E. L. H.; Lee, K.-T.; Goh, F.-J.; Bozkurt, T. O.; Wu, C.-H.

10.1101/2025.01.21.634219 — plant biology — Posted on 2025-04-08

3908 DeNoFo: a file format and toolkit for standardised, comparable de novo gene annotation

Dohmen, E.; Aubel, M.; Eicholt, L. A.; Roginski, P.; Luria, V.; Karger, A.; Grandchamp, A.

10.1101/2025.03.31.644673 — bioinformatics — Posted on 2025-04-08

3909 Structural insights into heterohexameric assembly of epilepsy-related ligand-receptor complex LGI1-ADAM22

Yamaguchi, T.; Okatsu, K.; Kubota, M.; Mitsumori, A.; Yamagata, A.; Fukata, Y.; Fukata, M.; Shibata, M.; Fukai, S.

10.1101/2025.01.06.631603 — biochemistry — Posted on 2025-04-08

3910 MCAK Recognizes the Nucleotide-Dependent Feature at Growing Microtubule Ends

Chen, W.; Song, Y.-L.; He, J.; Liang, X.

10.1101/2023.10.02.560461 — biochemistry — Posted on 2025-04-08

3911 Analyzing coordinated group behavior through role-sharing: A pilot study in female 3-on-3 basketball with practical application

Ichikawa, J.; Yamada, M.; Fujii, K.

10.1101/2024.09.16.612561 — animal behavior and cognition — Posted on 2025-04-08

3912 Calcineurin controls the cytokinesis machinery during thermal stress in Cryptococcus deneoformans

Yadav, V.; Averette, A.; Upadhya, R.; Heitman, J.

10.1101/2025.02.17.638697 — genetics — Posted on 2025-04-08

3913 Gut microbiota-mediated lipid accumulation as a driver of evolutionary adaptation to blue light toxicity in Drosophila

Takada, Y.; Ichinose, T.; Fuse, N.; Saito, K.; Ikeda-Ohtsubo, W.; Tanimoto, H.; Hori, M.

10.1101/2024.08.22.608892 — evolutionary biology — Posted on 2025-04-08

3914 Fast evolutionary turnover and overlapping variances of sex-biased gene expression patterns defy a simple binary sex-classification of somatic tissues

Xie, C.; Kuenzel, S.; Tautz, D.

10.1101/2024.05.22.595301 — evolutionary biology — Posted on 2025-04-08

3915 In-vivo Efficacy of a Phage Cocktail Therapy that Targets ESBL-producing Klebsiella species that cause Urinary Tract Infections

Jariah, R. O. A.; Schofield, J.; West, K.; Michniewski, S.; Jameson, E.; Onions, L.; Saravanan, A.; Yesilkaya, H.; Millard, A. D.; Clokie, M. R. J.; Haines, M. E. K.

10.1101/2025.04.01.646603 — microbiology — Posted on 2025-04-08

3916 Ninjurin-1 mediated plasma membrane rupture is a two-step process requiring cell swelling

Hartenian, E.; Bernard, E. M.; Ammirati, G.; Leloup, H. B.; Agustoni, M.; Bissegger, L.; Santos, J. C.; Glück, I.; Mari, S.; Sieben, C.; Petrilli, V.; Monnier, S.; Müller, D.; Broz, P.

10.1101/2024.10.29.620849 — immunology — Posted on 2025-04-08

3917 Ternary Neurexin-T178-PTPR complexes represent a presynaptic core-module of neuronal synapse organization

10.1101/2024.07.16.603715 — neuroscience — Posted on 2025-04-08

3918 The Orphan G Protein-Coupled Receptor GPR52 is a Novel Regulator of Breast Cancer Multicellular Organization

Hanif, S. Z.; Au, C. C.; Torregroza, I.; Kutz, C.; Jannath, S.; Fabiha, T.; Bhinder, B.; Washburn, M.; Devost, D.; Liu, S.; Bhardwaj, P.; Evans, T.; Anand, P. K.; Tarran, R.; Palikhe, S.; Elemento, O.; Dow, L. E.; Blenis, J.; Hebert, T.; Brown, K. A.

10.1101/2024.07.22.604482 — cancer biology — Posted on 2025-04-08

3919 Fully three-dimensional force inference in intestinal organoids reveals ratchet-like bud stabilization

Drozdowski, O. M.; Boonekamp, K. E.; Engel, U.; Boutros, M.; Schwarz, U. S.

10.1101/2025.04.02.646749 — biophysics — Posted on 2025-04-08

3920 Repurposing without Reinventing the Wheel - Ensemble Models for Differential Analysis

Chatterjee, S.; Paul, E.; Liu, Z.; Gao, J.; Basak, P.; Bhattacharyya, A.; Banerjee, C.; Mallick, H.

10.1101/2025.04.07.647549 — bioinformatics — Posted on 2025-04-08

3921 Photocrosslinkable and biodegradable hydrogels for the controlled delivery of exosomes

Ayala-Mar, S.; Jeon, O.; Chacon-Ponce, P.; Gonzalez-Valdez, J.; Alsberg, E. A.

10.1101/2025.04.01.646472 — bioengineering — Posted on 2025-04-08

3922 PISA: a versatile interpretation tool for visualizing cis-regulatory rules in genomic data

Zeitlinger, J.; McAnany, C. E.; Weilert, M.; Kamulegeya, F.; Mehta, G.; Gardner, J. M.; Kundaje, A.

10.1101/2025.04.07.647613 — genomics — Posted on 2025-04-08

3923 A novel, wave-shaped profile of germline selection of pathogenic mtDNA mutations is discovered by bypassing a classical statistical bias.

Franco, M.; Cote-LHeureux, A.; Fleischmann, Z.; Chen, Z.; Khrapko, M.; Vyshedskiy, B.; Braverman, M.; Popadin, K.; Pickett, S.; Woods, D. C.; Tilly, J.; Turnbull, D.; Khrapko, K.

10.1101/2023.11.21.568140 — genomics — Posted on 2025-04-08

3924 Reshaping epistatic network modules enhances wheat yield potential

Yin, M.; Han, H.; Liu, W.; Kong, L.; Li, X.; Ji, W.; Wu, J.; Deng, G.; Dong, H.; Zhang, J.; Zhou, S.; Zhang, Z.; Hou, Y.; Wang, H.; Zhao, C.; Li, X.; Luo, Q.; Guo, X.; Yang, X.; Ling, H.-Q.; He, F.; Li, L.

10.1101/2025.04.01.646715 — genetics — Posted on 2025-04-08

3925 Genome-wide analysis reveals genes mediating resistance to paraquat neurodegeneration in Drosophila

Villalobos-Cantor, S.; Arreola-Bustos, A.; Martin, I.

10.1101/2025.04.02.646829 — genetics — Posted on 2025-04-08

3926 Non-linear Age-related Change in Human Interleukin-11 and the receptor subunit alpha DNA Methylation

Shimura, A.; Dwaraka, V. B.; Yamanishi, K.; Seki, T.; Nishiguchi, T.; Aoyama, B.; Ishii, T.; Phuong, N. J.; Gorantla, N.; Nguyen, H. D.; Santiago, T.; Nishitani, S.; Smith, R.; Shinozaki, G.

10.1101/2025.04.01.646733 — genetics — Posted on 2025-04-08

3927 ANKZF1 helps to eliminate the stress-damaged mitochondria by LC3-mediated mitophagy

Ali, M.; Anjali, ; Mapa, K.

10.1101/2024.11.05.622196 — cell biology — Posted on 2025-04-08

3928 Scrib organizes cortical actomyosin clusters to maintain adherens junctions and angiogenic sprouting

Mayo, L. N.; Duong, F.; Mompeon, A.; Jacobs, K. A.; Iruela-Arispe, M. L.; Kutys, M. L.

10.1101/2025.04.01.645927 — cell biology — Posted on 2025-04-08

3929 Chaparral wildfire shifts the functional potential for soil pyrogenic organic matter and nitrogen cycling

Pulido-Chavez, M. F.; Nelson, A. R.; Wilkins, M. R.; Glassman, S. I.; Homyak, P. M.

10.1101/2024.08.18.607989 — microbiology — Posted on 2025-04-08

3930 Oral antigen exposure under co-stimulation blockade generates Treg cells to establish immune tolerance despite prior sensitization

Arai, M.; Kawakami, R.; Nakamura, Y.; Naito, Y.; Motooka, D.; Sugimoto, A.; Kimoto, T.; Ohkura, N.; Mikami, N.; Sakaguchi, S.

10.1101/2025.04.02.646742 — immunology — Posted on 2025-04-08

3931 Subtypes and proliferation patterns of small intestine neuroendocrine tumors revealed by single cell RNA sequencing

Somech, E.; Halder, D.; Spitzer, A.; Barbolin, C.; Tyler, M.; Halperin, R.; Biton, M.; Tirosh, A.; Tirosh, I.

10.1101/2024.07.29.605642 — cancer biology — Posted on 2025-04-08

3932 Datavzrd: Rapid programming- and maintenance-free interactive visualization and communication of tabular data

Wiegand, F. C.; Lähnemann, D.; Mölder, F.; Uzuner, H.; Prinz, A.; Schramm, A.; Köster, J.

10.1101/2025.04.03.647146 — bioinformatics — Posted on 2025-04-08

3933 CanASM: A comprehensive database for genome-wide allele-specific DNA methylation identification and annotation in cancer

Li, H.; Yu, H.; Lin, H.; Chen, H.; Li, X.; Liu, D.; Wang, Y.; Wang, G.

10.1101/2025.04.03.646980 — bioinformatics — Posted on 2025-04-08

3934 DockFormer: Affinity Prediction and Flexible Docking with Pair Transformer

Shor, B.; Schneidman-Duhovny, D.

10.1101/2024.11.25.625135 — bioinformatics — Posted on 2025-04-08

3935 PyVADesign: a Python-based cloning tool for one-step generation of large mutant libraries

Kuin, R. C. M.; Lamers, M. H.; van Westen, G. J. P.

10.1101/2025.04.04.647202 — bioinformatics — Posted on 2025-04-08

3936 Benchmarking single-cell multi-modal data integrations

Fu, S.; Wang, S.; Si, D.; Li, G.; Gao, Y.; Liu, Q.

10.1101/2025.04.01.646578 — bioinformatics — Posted on 2025-04-08

3937 GPCRchimeraDB: A database of chimeric G protein-coupled receptors (GPCRs) to assist their design

Crauwels, C.; Diaz, A.; Vranken, W. F.

10.1101/2024.12.16.628733 — bioengineering — Posted on 2025-04-08

3938 Small-molecule modulation of Beta-arrestins

Kahsai, A. W.; Pakharukova, N.; Kwon, H. Y.; Shah, K. S.; Liang-Lin, J. G.; del Real, C. T.; Shim, P. J.; Lee, M. A.; Ngo, V. A.; Shreiber, B. N.; Liu, S.; Schwalb, A. M.; Espinoza, E. F.; Thomas, B. N.; Kunzle, C. A.; Smith, J. S.; Wang, J.; Kim, J.; Zhang, X.; Rockman, H. A.; Thomsen, A. R. B.; Rein, L. A. M.; Shi, L.; Ahn, S.; Masoudi, A.; Lefkowitz, R. J.

10.1101/2024.12.27.630464 — biochemistry — Posted on 2025-04-08

3939 Motivational trade-offs as evidence for sentience in bees: a critique

Read, J.; Nityananda, V.

10.1101/2025.04.04.647054 — animal behavior and cognition — Posted on 2025-04-08

3940 GUIDE deconstructs genetic architectures using association studies

Lazarev, D.; Chau, G.; Bloemendal, A.; Churchhouse, C.; Neale, B.

10.1101/2024.05.03.592285 — genetics — Posted on 2025-04-08

3941 Genome structural variation in natural Caenorhabditis elegans populations

Lesack, K. J.; Wasmuth, J. D.

10.1101/2025.01.07.631790 — evolutionary biology — Posted on 2025-04-08

3942 Molecular phylogenetics illuminates the evolutionary history and hidden diversity of Australian cave crickets (Orthoptera: Rhaphidophoridae)

Beasley-Hall, P. G.; Trewick, S. A.; Eberhard, S. M.; Zwick, A.; Reed, E. H.; Cooper, S. J. B.; Austin, A. D.

10.1101/2024.08.11.607522 — evolutionary biology — Posted on 2025-04-08

3943 Scalable Image-Based Quantification of Cell Permeability and Actin Remodeling: An Example in a Gut-on-Chip Platform

Morelli, M.; Queiroz, K.

10.1101/2025.04.04.647153 — cell biology — Posted on 2025-04-08

3944 Targeting Regulatory Factors Associated with the Drosophila Myc cis-Elements by Reporter Expression, Gel Shift Assay, and Mass Spectrometric Protein Identification

Kharazmi, J.; Brody, T.; Moshfegh, C.

10.1101/2025.04.04.647281 — molecular biology — Posted on 2025-04-08

3945 Comparative genomics reveals intra and inter species variation in the pathogenic fungus Batrachochytrium dendrobatidis

Yacoub, M. N.; Stajich, J. E.

10.1101/2024.01.24.576925 — microbiology — Posted on 2025-04-08

3946 Epigenetic memory astrocytes are likely an artifact of immune cell contamination

O'Dea, M. R.; Liddelow, S. A.

10.1101/2025.04.04.647246 — neuroscience — Posted on 2025-04-08

3947 Scaling, but not instruction tuning, increases large language models' alignment with language processing in the human brain

Gao, C.; Ma, Z.; Chen, J.; Li, P.; Huang, S.; Li, J.

10.1101/2024.08.15.608196 — neuroscience — Posted on 2025-04-08

3948 The role of the right language network and the multiple-demand network in verbal semantics: Insights from an Activation Likelihood Estimation Meta-analysis of 561 Functional Neuroimaging Studies

Demirkan, E.; Branzi, F. M.

10.1101/2025.04.05.647349 — neuroscience — Posted on 2025-04-08

3949 Le Petit Prince (LPP) Multi-talker: Naturalistic 7T fMRI and EEG Dataset

Li, J.; Wang, Q.; Wang, Y.; Wang, C.; Ma, Z.; Xu, R.; Feng, S.; Jiang, X.; Meng, Z.

10.1101/2025.04.03.646958 — neuroscience — Posted on 2025-04-08

3950 Atypical Alpha Oscillatory EEG Dynamics in Children with Angelman Syndrome

Dickinson, A. H.; Bowen-Kauth, S.; Shide, J. J.; Youngkin, A. E.; Hosamane, N. S.; McNair, C. A.; Ryan, D. P.; Chu, C. J.; Sidorov, M. S.

10.1101/2025.04.03.647110 — neuroscience — Posted on 2025-04-08

3951 The novel role of Kallistatin in linking metabolic syndromes and cognitive memory deterioration by inducing amyloid-β plaques accumulation and tau protein hyperphosphorylation

Qi, W.; Long, Y.; Li, Z.; Zhao, Z.; Shi, J.; Xie, W.; Wang, L.; Tan, Y.; Zhou, T.; Liang, M.; Jiang, P.; Jiang, B.; Yang, X.; Gao, G.

10.1101/2024.05.20.594915 — neuroscience — Posted on 2025-04-08

3952 The Physiological Component of the BOLD Signal: Impact of Age and Heart Rate Variability Biofeedback Training

Song, R. W.; Min, J.; Wang, S.; Goodale, S. E.; Rogge-Obando, K.; Yang, R.; Yoo, H. J.; Nashiro, K.; Chen, J. E.; Mather, M.; Chang, C.

10.1101/2025.04.04.647252 — neuroscience — Posted on 2025-04-08

3953 Deep Learning-Driven Gender Classification of Drosophila melanogaster: Advancing Real-Time Analysis with Mobile Integration

Rai, J.; S, A.; Paul, S.; Shelke, T.; Gupta, I.

10.1101/2025.04.04.647141 — scientific communication and education — Posted on 2025-04-08

3954 A hydrophobic core in the coiled-coil domain is essential for NRC resistosome function

Wang, H.-Y.; Yuen, E. L. H.; Lee, K.-T.; Goh, F.-J.; Bozkurt, T. O.; Wu, C.-H.

10.1101/2025.01.21.634219 — plant biology — Posted on 2025-04-08

3955 PAC: A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures

Anderson, L. L.; Kahlig, K. M.; Barker-Haliski, M. L.; Hannigan, B.; Toop, H.; Matthews, L. G.; French, J.; White, H. S.; Souza, M.; Petrou, S.

10.1101/2025.04.04.647239 — pharmacology and toxicology — Posted on 2025-04-08

3956 COVID-19 vaccination induces cross-neutralisation of sarbecoviruses related to SARS-CoV-2

West, G.; Morse, R.; Sievers, B. L.; Abdullahi, A.; Kamelian, K.; Cheng, M.; Bioresource, C. N.; Stewart, D.; David, D.; Robertson, D. L.; Lytras, S.; Wilson, S. J.; Rihn, S. J.; Gupta, R. K.

10.1101/2025.04.04.647203 — microbiology — Posted on 2025-04-07

3957 Intranasal sarbecovirus vaccine booster elicits cross-clade, durable and protective systemic and mucosal immunity

CHEANG, N. Y. Z.; YAP, W. C.; TULLETT, K. M.; Qian, X.; TAN, P. S.; Purushotorman, K.; TAN, W. Y.; MAH, S. Y. Y.; MacAry, P. A.; TAN, C. W.; Lahoud, M. H.; ALONSO, S.

10.1101/2025.04.04.647326 — immunology — Posted on 2025-04-07

3958 Inverse Game Theory Characterizes Frequency-Dependent Selection Driven by Karyotypic Diversity in Triple Negative Breast Cancer

Veith, T.; Beck, R. J.; Brown, J. S.; Andor, N.

10.1101/2025.03.23.644809 — cancer biology — Posted on 2025-04-07

3959 A fractal pattern of hierarchical genetic population structure in mixed stocks across fish segregated by dams revealed by genomic resources for curimba Prochilodus lineatus

Yazbeck, G. M.; Nascimento, G. A. S.; Carvalho, L. C.; Graciano, R. C. D.; Santos, R.; Oliveira, R. S.

10.1101/2025.03.14.643328 — genetics — Posted on 2025-04-07

3960 Gene Novelties in Amphioxus Illuminate the Early Evolution of Cephalochordates

Xiong, Q.; Yang, K. Y.; Zeng, X.; Wang, M.; Ng, P. K.-S.; Zhou, J.-W.; Ng, J. K.-W.; Law, C. T.-Y.; Du, Q.; Xu, K.; Mao, B.; Tsui, S. K.-W.

10.1101/2022.05.18.492404 — evolutionary biology — Posted on 2025-04-07

3961 Direct visualization and tracing of DNA fold in Drosophila embryo

Fatmaoui, F.; Carrivain, P.; Taiki, F.; Grewe, D.; Hagen, W. J.; Jacob, B.; Victor, J.-M.; Leforestier, A.; Eltsov, M.

10.1101/2022.08.16.502515 — cell biology — Posted on 2025-04-07

3962 Evolution and instability of human centromeres are accelerated by heterochromatin boundary loss and CENP-A overexpression

Mahlke, M. A.; Lumerman, L.; Nath, P.; Chittenden, C.; Hoyt, S.; Koeppel, J.; Xu, Y.; Raphael, R.; Zaffina, K.; Hook, P. W.; Timp, W.; Miga, K. H.; Campbell, P.; O'Neill, R. J.; Altemose, N.; Nechemia-Arbely, Y.

10.1101/2025.02.03.636285 — cell biology — Posted on 2025-04-07

3963 Diverse bacteriohemerythrin genes of Methylomonas denitrificans FJG1 provide insight into the survival and activity of methanotrophs in low oxygen ecosystems

Weiblen, C.; Kits, K. D.; Kleiner, M.; Sauvageau, D.; Stein, L. Y.

10.1101/2024.01.07.574550 — microbiology — Posted on 2025-04-07

3964 Global Metagenomics Reveals Hidden Protist Diversity

Gutierrez, M. F. R.; Krinos, A. I.; Alcala, X. M.; Burns, J. A.; Stepanauskas, R.; Woyke, T.; Schulz, F.

10.1101/2025.03.26.645542 — microbiology — Posted on 2025-04-07

3965 Measuring the functional complexity of nanoscale connectomes: polarity matters

Wang, Q.; Randel, N.; Yin, Y.; Shand, C.; Strange, A.; Winding, M.; Cardona, A.; Zlatic, M.; Vogelstein, J.; Priebe, C.

10.1101/2024.09.24.614724 — neuroscience — Posted on 2025-04-07

3966 Standardised TruAI automated quantification of intracellular neuromelanin granules in human brain tissue sections

Filimontseva, A.; Cuadros, T.; Chatterton, Z.; Compte, J.; Fu, Y.; Vila, M.; Halliday, G.

10.1101/2025.01.20.633975 — neuroscience — Posted on 2025-04-07

3967 Oxygen intrusions sustain aerobic nitrite-oxidizing bacteria in anoxic marine zones

Buchanan, P. J.; Sun, X.; Weissman, J.; McCoy, D.; Bianchi, D.; Zakem, E. J.

10.1101/2023.02.22.529547 — systems biology — Posted on 2025-04-07

3968 New Spatiotemporal Phenomena in Cancer-Host Interactionsand Tumor Functional Border Definition via Electrical Impedance Dynamics

Babich, Y. F.

10.1101/2025.01.29.635448 — cancer biology — Posted on 2025-04-07

3969 A transfer RNA methyltransferase with an unusual domain composition catalyzes 2'-O-methylation at position 6 in tRNA

Matsuda, T.; Yamagami, R.; Ihara, A.; Suzuki, T.; Hirata, A.; Hori, H.

10.1101/2025.04.03.647152 — biochemistry — Posted on 2025-04-07

3970 Viral community diversity in the rhizosphere of the foundation salt marsh plant Spartina alterniflora

Du Plessis, I.; Snyder, H.; Calder, R.; Rolando, J.; Kostka, J. E.; Weitz, J. S.; Dominguez-Mirazo, M.

10.1101/2025.04.03.647062 — genomics — Posted on 2025-04-07

3971 Quantifying plasmid movement in drug-resistant Shigella species using phylodynamic inference

Müller, N. F.; Wick, R. R.; Judd, L. M.; Williamson, D. A.; Bedford, T.; Howden, B.; Duchene, S.; Ingle, D. J.

10.1101/2022.10.27.514108 — evolutionary biology — Posted on 2025-04-07

3972 An updated dataset of early SARS-CoV-2 diversity supports a wildlife market origin

Hensel, Z.; Debarre, F.

10.1101/2025.04.05.647275 — microbiology — Posted on 2025-04-07

3973 The global proteome of Streptococcus pneumoniae EF3030 under nutrient-defined in vitro conditions

De, S.; Busch, L. M.; Burchhardt, G.; Gesell Salazar, M.; Schlueter, R.; Steil, L.; Voelker, U.; Hammerschmidt, S.

10.1101/2025.04.07.647550 — microbiology — Posted on 2025-04-07

3974 Intramacrophage RIL-seq uncovers an RNA antagonist of the Salmonella virulence-associated small RNA PinT

Kooshapour, H.; Matera, G.; Venturini, E.; Bischler, T.; Vogel, J.; Westermann, A. J.

10.1101/2025.04.07.647523 — microbiology — Posted on 2025-04-07

3975 Obligate intracellular Orientia tsutsugamushi impedes TP53 expression to inhibit DNA damage-induced apoptosis

Allen, P. E.; Armistead, D. L.; Blinova, S.; Carlyon, J. A.

10.1101/2025.04.07.647604 — microbiology — Posted on 2025-04-07

3976 Plasmodium falciparum DNA repair dynamics reveal unique roles for TLS polymerases and PfRad51 in genome diversification

Vishwanatha, A.; Zhang, X.; Liu, Y. J.; Leung, A.; Herring, M.; Chan, A.; Calhoun, S.; Deitsch, K. W.; Kirkman, L.

10.1101/2025.04.07.647301 — microbiology — Posted on 2025-04-07

3977 Coordination Between Cytoplasmic and Envelope Densities Shapes Cellular Geometry in Escherichia coli

Chure, G. D.; de Silva, R. T.; Sharma, R.; Lanz, M.; Cremer, J.

10.1101/2023.10.28.564462 — microbiology — Posted on 2025-04-07

3978 Genomic insights into polysaccharide substrate utilization and novel genera resource mining in macroalgal epiphytic bacteria

Liu, T.; Zhou, H.-Y.; Zhang, H.-Z.; Wang, F.-Q.; Liu, Y.-Z.; Teng, J.-H.; Fan, S.-J.; Lu, D.-C.; Du, Z.

10.1101/2025.04.07.647558 — microbiology — Posted on 2025-04-07

3979 Enterovirus D68 infection of human inducible pluripotent stem cell-derived skeletal muscles resulted in structural destruction, loss of muscle function and hampered muscle regeneration

Laksono, B. M.; Bergsma, A. J.; Iuliano, A.; Veldhoen, D. Y.; van Nieuwkoop, S.; Boter, M.; Leijten, L.; Bauer, L.; Munnink, B. B. O.; Pijnappel, W. W. M. P.; van Riel, D.

10.1101/2025.04.07.647509 — microbiology — Posted on 2025-04-07

3980 Stochastic variation in surface protein expression diversifies Trypanosoma cruzi infection

Cruz Saavedra, L.; Loock, M.; Antunes, L. B.; Cestari, I.

10.1101/2025.04.07.647584 — microbiology — Posted on 2025-04-07

3981 Bacteria with antibacterial activities isolated from Magallana gigas microbiota as potential probiotics against Vibrio aestuarianus infections in oyster farming

Dantan, L.; Travers, M.-A.; Degremont, L.; Morga, B.; Carcassonne, P.; Mege, M.; Fleury, Y.; Petton, B.; Maurouard, E.; Allienne, J.-F.; Courtay, G.; Romatif, O.; Lami, R.; Intertaglia, L.; Gueguen, Y.; Vidal-Dupiol, J.; Cosseau, C.; Toulza, E.

10.1101/2025.04.07.647571 — microbiology — Posted on 2025-04-07

3982 The increase in cell volume and nuclear number of the koji-fungus Aspergillus oryzae contributes to its high enzyme productivity

Itani, A.; Motomura, H.; Oda, K.; Yamashita, H.; Sakai, K.; Kusumoto, K.-i.; Shigeto, S.; Ichikawa, T.; Mubarak, H. M.; Fukuma, T.; Katayama, T.; Maruyama, J.-i.; Masuo, S.; Takaya, N.; Takeshita, N.

10.1101/2025.04.06.647446 — microbiology — Posted on 2025-04-07

3983 Pharmacological inhibition of host pathways enhances macrophage killing of intracellular bacterial pathogens

Rijal, R.; Gomer, R. H.

10.1101/2025.04.06.647500 — microbiology — Posted on 2025-04-07

3984 Uromyces plumbarius first reported on Oenothera lindheimeri in Europe with widespread distribution and association with the rust hyperparasite Sphaerellopsis sp.

Suffert, F.; Meyer, K.; Laval, V.; Andrieux, A.; Slootweg, E.; Frey, P.

10.1101/2025.04.07.647624 — microbiology — Posted on 2025-04-07

3985 Simple and quantitative detection of double-stranded RNA as a signature of pan-virus infections using a luciferase-based biosensor

Sasaki, M.; Fujii, E.; Sasaki, S.; Ariizumi, T.; Konishi, K.; Sato, A.; Hall, W. W.; Sawa, H.; Orba, Y.

10.1101/2025.04.07.647538 — microbiology — Posted on 2025-04-07

3986 Low affinity noradrenergic signaling promotes passive coping during reinforcement behavior

Rodberg, E. M.; Vazey, E. M.

10.1101/2025.04.05.647394 — neuroscience — Posted on 2025-04-07

3987 Knockout of P2Y12 receptor facilitates microglia-neuron body-to-body interactions and accelerates prion disease

Makarava, N.; Safadi, T.; Bocharova, O.; Mychko, O.; Pandit, N. P.; Molesworth, K.; Eyo, U. B.; Baskakov, I. V.

10.1101/2025.04.07.647619 — neuroscience — Posted on 2025-04-07

3988 Projection-TAGs enable multiplex projection tracing and multi-modal profiling of projection neurons

Yang, L.; Liu, F.; Hahm, H.; Okuda, T.; Li, X.; Zhang, Y.; Kalyanaraman, V.; Heitmeier, M. R.; Samineni, V. K.

10.1101/2024.04.24.590975 — neuroscience — Posted on 2025-04-07

3989 A data-driven approach to identifying and evaluating connectivity-based neural correlates of consciousness

Bryant, A. G.; Whyte, C. J.

10.1101/2025.04.06.646695 — neuroscience — Posted on 2025-04-07

3990 Harmonizing Inter-Site Differences in T1-Weighted Images Using CycleGAN

Shimizu, M.; Yamashita, Y.; Yamaguchi, H.; Oishi, N.; Takahashi, H.; Sugihara, G.

10.1101/2025.04.07.646944 — neuroscience — Posted on 2025-04-07

3991 High-throughput measurements of neuronal activity in single human iPSC-derived glutamate neurons

Gameiro-Ros, I. M.; Tengolics, A. J.; Prytkova, I.; Kamarajan, C.; Pang, Z. P.; Goate, A. M.; Hart, R. P.; Slesinger, P. A.

10.1101/2025.04.07.646449 — neuroscience — Posted on 2025-04-07

3992 Connectomic traces of Hebbian plasticity in the entorhinal-hippocampal system

Grasso, E.; Corteze, M.; Schmidt, H.

10.1101/2025.04.07.647631 — neuroscience — Posted on 2025-04-07

3993 Differential Effects of Short-term and Long-term Deep Brain Stimulation on Striatal Neuronal Excitability in a Dystonia Animal Model

Heerdegen, M.; Franz, D.; Neubert, V.; Kragelund, F.; Sellmann, T.; Werner-Schmolling, C.; Starke, J.; Spiliotis, K.; Richter, F. A.; Richter, A.; Kohling, R.

10.1101/2025.04.07.647541 — neuroscience — Posted on 2025-04-07

3994 Gaze-centered spatial coding of touch on a hand-held tool

Zografos, L.; Medendorp, W. P.; Miller, L.

10.1101/2025.04.04.647167 — neuroscience — Posted on 2025-04-07

3995 Decoding the Moving Mind: Multi-Subject fMRI-to-Video Retrieval with MLLM Semantic Grounding

Zhu, X.; Chai, Y.; Li, R.; Lan, M.; Gao, L.

10.1101/2025.04.07.647335 — neuroscience — Posted on 2025-04-07

3996 Astrocytic connexin43 phosphorylation contributes to seizure susceptibility after mild Traumatic Brain Injury

Munoz-Ballester, C.; Leitzel, O. J.; Golf, S. R.; Phillips, C. M.; Zeitz, M. J.; Pandit, R.; Wash, E.; Donohue, J. V.; Smyth, J. W.; Lamouille, S.; Robel, S.

10.1101/2024.11.12.623104 — neuroscience — Posted on 2025-04-07

3997 The minimal cell-cycle control system in Marchantia as a framework for understanding plant cell proliferation

Romani, F.; Bonter, I.; Rebmann, M.; Takahashi, G.; Guzman-Chavez, F.; De Batte, F.; Hirakawa, Y.; Haseloff, J.

10.1101/2025.03.12.642684 — plant biology — Posted on 2025-04-07

3998 Acid-Sensing Ion Channel 1a Deficiency Drives Endocrine Hypertension in Male Mice

Garcia, S. M.; Tuineau, M. N.; DeLeon, X. A.; Detweiler, N. D.; Tamang, S.; Kanagy, N. L.; Gonzalez Bosc, L. V.; Resta, T. C.; Naik, J. S.; Jernigan, N. L.

10.1101/2025.03.25.645371 — physiology — Posted on 2025-04-07

3999 Learning the cellular origins of cancer using single-cell chromatin landscapes

Bairakdar, M. D.; Giotti, B.; Lee, W.; Stancl, P.; Wagenblast, E.; Hambardzumyan, D.; Polak, P.; Karlic, R.; Tsankov, A.

10.1101/2025.04.06.646131 — cancer biology — Posted on 2025-04-07

4000 Single-cell dynamics reveal a stress-induced decision between cardiomyocyte hypertrophy and apoptosis

Chun, B.; Ngo, L.; Saucerman, J. J.

10.1101/2021.03.17.435783 — bioinformatics — Posted on 2025-04-07

4001 Genomic Dissection of Metabolism, Prophage Elements, and Ecological Adaptations in Candidatus Liberibacter asiaticus

KP, S.; Sharma, A. K.; Singla, J.

10.1101/2025.04.04.647159 — biochemistry — Posted on 2025-04-07

4002 Neural correlates of image memorability: Combining large-scale 7T fMRI with machine learning-based predictions

Maki-Marttunen, V.; Hagen, T.; Espeseth, T.

10.1101/2025.04.06.647493 — animal behavior and cognition — Posted on 2025-04-07

4003 Comparison of whole-genome assemblies of European river lamprey (Lampetra fluviatilis) and brook lamprey (Lampetra planeri)

Torresen, O. K.; Garmann-Aarhus, B.; Hoff, S. N. K.; Jentoft, S.; Svensson, M.; Schartum, E.; Tooming-Klunderud, A.; Skage, M.; Krabberod, A.; Vollestad, L. A.; Jakobsen, K. S.

10.1101/2024.12.06.627158 — genomics — Posted on 2025-04-07

4004 Regulation of epigenetics and chromosome structure by human ORC2

Su, Z.; Tian, M.; Shibata, E.; Shibata, Y.; Yang, T.; Wang, Z.; Jin, F.; Zang, C.; Dutta, A.

10.1101/2024.12.18.629220 — genomics — Posted on 2025-04-07

4005 WRN and WRNIP1 ATPases impose high fidelity on translesion synthesis by Y-family DNA polymerases

Yoon, J. H.; Sellamuthu, K.; Pakash, L.; Prakash, S.

10.1101/2025.04.02.646818 — genetics — Posted on 2025-04-07

4006 Effective population size does not explain long-term variation in genome size and transposable element content in animals

Marino, A.; Debaecker, G.; Fiston-Lavier, A.-S.; Haudry, A.; Nabholz, B.

10.1101/2024.02.26.582137 — evolutionary biology — Posted on 2025-04-07

4007 How The Transition of Aphid Life Cycles Affect Endosymbiotic Bacteria

Tong, X.; Akimoto, S.-i.; Nozaki, T.; Arita, M.; Shigenobu, S.

10.1101/2025.04.02.646943 — evolutionary biology — Posted on 2025-04-07

4008 Spatial Transcriptomics Unveils the Blueprint of Mammalian Lung Development

Chen, M. y.; Lv, J. j.; Zhang, Q.; Gong, Q.; Zhao, T.; Chen, Z. p.; Xu, H. s.; Zhou, N.; Du, J.; Chen, X. p.; Ke, Y. w.

10.1101/2025.04.05.647413 — developmental biology — Posted on 2025-04-07

4009 Unlocking the Distinct Roles of the Three Mammalian VDAC Isoforms in Mitochondrial Respiration and Cancer Cell Metabolism

Rajendran, M.; Rosencrans, W. M.; Fitzgerald, W.; Huynh, D.; Beyene, B. G.; Quan, B.; Hwang, J.; Bautista, N. A.; Chou, T.-F.; Bezrukov, S. M.; Rostovtseva, T. K.

10.1101/2025.02.20.639106 — cell biology — Posted on 2025-04-07

4010 Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex

Dietrich, M.; Chmielewski, J.; Chan, L.-J.; Tan, L. L.; Adair, A.; Lyons, F.; Gabriela, M.; Lopaticki, S.; Dite, T.; Dagley, L.; Pazzagli, L.; Gupta, P.; Kamil, M.; Vaughan, A. M.; Rojrung, R.; Abraham, A.; Mazhari, R.; Longley, R. J.; Zeglinski, K.; Gouil, Q.; Mueller, I.; Fabb, S.; Shandre-Mugan, R.; Pouton, C. W.; Glukhova, A.; Shakeel, S.; Tham, W.-H.

10.1101/2025.02.13.638205 — microbiology — Posted on 2025-04-07

4011 The MarR Family Transcription Factor SlyASenses Iron and Respiratory Status in Enteric Bacteria

Will, W. R.; Fang, F. C.

10.1101/2025.04.07.647610 — microbiology — Posted on 2025-04-07

4012 Inactivation of the Fusobacterium nucleatum Rnf complex reduces FadA-mediated amyloid formation and tumor development

Britton, T. A.; Lee, J. H.; Chang, C.; Bhat, A.; Chen, Y.-W.; Ali, R. M.; Wu, C.; Das, A.; Ton-That, H.

10.1101/2025.04.03.647037 — microbiology — Posted on 2025-04-07

4013 Enteric Viruses and Free-Living Amoebae: Protozoa as Potential Reservoirs and Transport Vessels for human Norovirus and Adenovirus

Leifels, M.; Dey, R.; Wiedmeyer, A.; Cheng, D.; Kolm, C.; Wu, F.; Sirikanchana, K.; Farnleitner, A. H.; Ashbolt, N. J.

10.1101/2025.04.07.647535 — microbiology — Posted on 2025-04-07

4014 Identifying Modulators of the Post-Antibiotic Effect

Gilberti, A. L.; Tu, M. M.; Rachwalski, K.; Ali, M. I.; Cohen, S. A.; Akoglu, M.; Pollard-Kerning, A. C.; Tolentino Collado, J.; Sabbah, A.; Abou Said, F.; Dela, P.; Walker, S. G.; Haley, J. D.; Brown, E. D.; Tonge, P. J.

10.1101/2025.04.06.647494 — microbiology — Posted on 2025-04-07

4015 Cell-type specific repertoire of responses to natural scenes in primate retinal ganglion cells

Kling, A.; Brackbill, N.; Rhoades, C. E.; Gogliettino, A.; Sher, A.; Litke, A.; Chichilnisky, E. J.

10.1101/2025.04.07.647118 — neuroscience — Posted on 2025-04-07

4016 Learning evoked centrality dynamics in the schizophrenia brain: Entropy, heterogeneity and inflexibility of brain networks

Bhatt, D.; Kopchick, J.; Abel, C. C.; Khatib, D.; Thomas, P.; Rajan, U.; Zajac-Benitez, C.; Haddad, L.; Amirsadri, A.; Stanley, J.; Diwadkar, V.

10.1101/2025.04.05.647398 — neuroscience — Posted on 2025-04-07

4017 YPEL controls synapse development through p62-Nrf2 antioxidant pathway in Drosophila neuromuscular junction

Wei, T.; Lashanizadegan, R.; Liu, L.; Singh, M.; Mariano, L. G. L.; Mathew, D.; Kim, J. H.

10.1101/2025.04.07.647271 — neuroscience — Posted on 2025-04-07

4018 Strategies used by two memories to share space in a common neural network

Mistry, V. K.; Hill, E. S.; Frost, W. N.

10.1101/2025.04.07.647298 — neuroscience — Posted on 2025-04-07

4019 Optogenetic disruption of neural dynamics in the prefrontal cortex impaired spatial learning

Negron-Oyarzo, I.; Dib, T.; Chacana-Veliz, L.; Barria, D.; Morales-Weil, K.; Fuenzalida, M.; Espinosa, N.

10.1101/2025.04.07.647582 — neuroscience — Posted on 2025-04-07

4020 Connecting the Dots: A Computational Framework linking Molecular Regulation, Synaptic Plasticity, and Brain Disorders

Li, Z.; Wu, W.; Li, W.; Wang, W.-X.

10.1101/2025.04.07.647510 — neuroscience — Posted on 2025-04-07

4021 Competition between tool and hand motion impairs movement planning in limb apraxia

Thibault, S.; Yates, J. B.; Buxbaum, L. J.; Wong, A. L.

10.1101/2025.04.07.647589 — neuroscience — Posted on 2025-04-07

4022 Visual pathway origins: an electron microscopic volume for connectomic analysis of the human foveal retina

10.1101/2025.04.05.647403 — neuroscience — Posted on 2025-04-07

4023 Optimizing Biophysical Large-Scale Brain Circuit Models With Deep Neural Networks

Zeng, T.; Tian, F.; Zhang, S.; Li, X.; Tan, A. P.; Larsen, B.; Gur, R. C.; Gur, R. E.; Moore, T. M.; Satterthwaite, T. D.; Deco, G.; Holmes, A. J.; Yeo, B. T. T.

10.1101/2025.04.07.647497 — neuroscience — Posted on 2025-04-07

4024 Nociceptor clock genes control excitability and pain perception in a sex- and time-dependent manner

Brecier, A.; Bannerman, C. A.; Xie, Y.-F.; Dedek, C.; Zacharias, A. M.; O'Connor, C. D.; Miller, S. D.; Ballantyne, L. L.; Du Bois, J.; Duan, Q.; Prescott, S. A.; Ghasemlou, N.

10.1101/2025.04.07.646998 — neuroscience — Posted on 2025-04-07

4025 Protocol for assessing DNA damage levels in vivo in rodent testicular germ cells in the Alkaline Comet Assay

Olsen, A.-K.; Ma, X.; Zheng, C.; Dahl, H.; Dirven, Y.; Boisen, A. M.; Sharma, A.; Eide, D. M.; Brunborg, G.

10.1101/2024.12.22.624648 — pharmacology and toxicology — Posted on 2025-04-07

4026 Analysis of intracellular and intercellular crosstalk from omics data.

Chiodi, A.; Pelucchi, P.; Mosca, E.

10.1101/2023.08.10.552776 — bioinformatics — Posted on 2025-04-07

4027 Autonomous learning of pathologists' cancer grading rules

Nguyen, T. H.; Panwar, V.; Jarmale, V.; Perny, A.; Dusek, C.; Cai, Q.; Kapur, P. H.; Danuser, G.; Rajaram, S.

10.1101/2025.03.18.643999 — bioinformatics — Posted on 2025-04-07

4028 Stoichiometric Insights into SARS-CoV-2 Spike-ACE2 Binding Across Variants

Akinwumi, I. A.; Bheemireddy, S.; CHALOIN, L.; Perez, S.; Khakzad, H.; Maigret, B.; Karami, Y.

10.1101/2025.04.04.647209 — bioinformatics — Posted on 2025-04-07

4029 A mathematical model of metacarpal subchondral bone adaptation, microdamage, and repair in racehorses

Pan, M.; Malekipour, F.; Pivonka, P.; Morrice-West, A. V.; Flegg, J. A.; Whitton, C.; Hitchens, P. L.

10.1101/2025.04.06.646486 — animal behavior and cognition — Posted on 2025-04-07

4030 Neural and Behavioral Dynamics of Acute Fentanyl Administration and Implications for Hazard Assessment of Novel Synthetic Opioids in Larval Zebrafish

Hillman, C. S.; Kearn, J.; Wasser-Bennett, G.; Trznadel, M.; Winter, M. J.; Parker, M. O.

10.1101/2025.04.07.647579 — animal behavior and cognition — Posted on 2025-04-07

4031 Upstream open reading frames buffer translational variability during Drosophila evolution and development

Sun, Y.; Duan, Y.; Gao, P.; Liu, C.; Jin, K.; Dou, S.; Tang, W.; Zhang, H.; Lu, J.

10.1101/2024.11.13.623404 — evolutionary biology — Posted on 2025-04-07

4032 Green cities and the risk for vector-borne disease transmission for humans and animals: a scoping review

Mercat, M.; Bartholomee, C.; Fournet, F.; Alcover Amengual, M.; Bourquia, M.; Bouhsira, E.; Cornel, A.; Fernandez-Cassi, X.; Fontenille, D.; Ibanez-Justicia, A.; Marti, R.; Moiroux, N.; Niang, E. H.; Smith, W.; Spitzen, J.; Visser, T.; Koenraadt, C. J. M.; Simard, F.

10.1101/2025.04.01.646559 — ecology — Posted on 2025-04-07

4033 Graphical Representation of Landscape Heterogeneity Identification through Unsupervised Acoustic Analysis

Guerrero, M. J.; Sanchez-Giraldo, C.; Martinez-Arias, V. M.; Uribe, C. A.; Isaza, C.

10.1101/2024.08.12.607639 — ecology — Posted on 2025-04-07

4034 Genetic compensation in podocalyxin-like mutants during zebrafish liver development

Ross, A. N.; Miscik, N. M.; Kalasekar, S. M.; Harris, J. D.; Tran, M.; Saxena, A.; Baker, S. A.; Evason, K. J.

10.1101/2025.04.07.647300 — developmental biology — Posted on 2025-04-07

4035 Tissue spreading couples gastrulation through extracellular matrix remodelling in early avian embryos

Balasubramaniam, L.; Ho, V. S. Y.; Gallo, F.; Mueller, K.; Xiong, F.

10.1101/2025.04.06.647388 — developmental biology — Posted on 2025-04-07

4036 The TWK-26/KCNK3 potassium channel and FLR-4 protein kinase coordinate nutrient absorption in the C. elegans intestine

Torzone, S. K.; Carroll, T.; Breen, P. C.; Cohen, N. R.; Simmons, K. N.; VanDerMolen, K. R.; Nehrke, K. W.; Dowen, R. H.

10.1101/2024.05.06.592787 — cell biology — Posted on 2025-04-07

4037 Transitions in dynamical regime and neural mode underlie perceptual decision-making

Luo, T. Z.; Kim, T. D.; Gupta, D.; Bondy, A. G.; Kopec, C. D.; Elliott, V. A.; DePasquale, B.; Brody, C.

10.1101/2023.10.15.562427 — neuroscience — Posted on 2025-04-07

4038 The brain dynamics of congenitally blind people seeing faces and letters via sound

Matusz, P. J. J.; Reich, L.; Stolz, L. A.; Retsa, C.; Tovar, D. A.; Striem-Amit, E. R.; Aggius-Vella, E.; Amedi, A.; Murray, M. M.

10.1101/2025.01.22.634358 — neuroscience — Posted on 2025-04-07

4039 Scalp EEG predicts intracranial brain activity in humans

Subramanian, A. K.; Talbot, A.; Kim, N.; Parmigiani, S.; Cline, C. C.; Solomon, E. A.; Hartford, J. W.; Huang, Y.; Mikulan, E.; Zauli, F. M.; d'Orio, P.; Cardinale, F.; Mannini, F.; Pigorini, A.; Keller, C.

10.1101/2025.04.07.647612 — neuroscience — Posted on 2025-04-07

4040 Bioinformatics-Driven Identification and Prioritization of PTSD Targets Based on Published Multi-omic Data

Zervas, M.; Gage, A.; Haas, M.

10.1101/2025.04.07.647615 — neuroscience — Posted on 2025-04-07

4041 Sulfotransferase 4A1 (SULT4a1): A Novel Neuroprotective Protein in Stroke

Hossain, M. I.; Khan, J.; Lee, J. H.; Falany, C. N.; King, P. H.; Bolding, M.; Andrabi, S. A.

10.1101/2025.04.07.647574 — neuroscience — Posted on 2025-04-07

4042 Mapping individualized multi-scale hierarchical brain functional networks from fMRI by self-supervised deep learning

Li, H.; Zhuo, C.; Cui, Z.; Cieslak, M.; Salo, T.; Gur, R. E.; Gur, R. C.; Shinohara, R. T.; Oathes, D. J.; Davatzikos, C.; Satterthwaite, T. D.; Fan, Y.

10.1101/2025.04.07.647618 — neuroscience — Posted on 2025-04-07

4043 Unreal? A Behavioral, Physiological, and Computational Model of the Sense of Reality

Drori, G.; Bar-Tal, P.; Hirsh, O.; Berlinger, A.; Goldberg, N.; Zvilichovsky, Y.; Hertz, U.; Zaidel, A.; Salomon, R.

10.1101/2025.04.07.647542 — neuroscience — Posted on 2025-04-07

4044 Leukemia Inhibitory Factor as a late-stage treatment for delayed white matter loss in concussive head injury

D'Mello, V. d.; Mihailovic, J.; Ali, S.; Sanganahalli, B. G.; Coman, D.; Hyder, F.; Fernando, M.; Mampilly, A.; Kannurpatti, S. S.; Levison, S. W.

10.1101/2025.04.07.647435 — neuroscience — Posted on 2025-04-07

4045 Flower/1 FLWR-1 regulates neuronal activity via the plasma membrane Ca2+-ATPase to promote recycling of synaptic vesicles

Seidenthal, M.; Redzovic, J.; Liewald, J. F.; Rentsch, D.; Shapiguzov, S.; Schuh, N.; Rosenkranz, N.; Eimer, S.; Gottschalk, A.

10.1101/2024.10.07.617020 — neuroscience — Posted on 2025-04-07

4046 Microglia and myeloid cell populations of the developing mouse retina

Martineau, S.; Valdez-Lopez, J. C.; Zarnick, S.; Kay, J. N.

10.1101/2025.04.07.646926 — neuroscience — Posted on 2025-04-07

4047 High-throughput histopathology for complex in vitro models

10.1101/2025.04.01.646522 — pathology — Posted on 2025-04-07

4048 Eye and hand coarticulation during problem solving reveals hierarchically organized planning

Eluchans, M.; Maselli, A.; Lancia, G. L.; Pezzulo, G.

10.1101/2024.11.18.624090 — animal behavior and cognition — Posted on 2025-04-07

4049 Benchmarking of spatial transcriptomics platforms across six cancer types

Cervilla, S.; Grases, D.; Perez, E.; Musulen, E.; Real, F. X.; Aprea-Perez, J.; Esteller, M.; Porta-Pardo, E.

10.1101/2024.05.21.593407 — genomics — Posted on 2025-04-07

4050 How drought and ploidy level shape gene expression and DNA methylation in Phragmites australis

Kuprina, K.; Haldan, K.; Saenko, S.; Gulam, M. S.; Kreyling, J.; Schnittler, M.; Bog, M.

10.1101/2025.03.31.646440 — ecology — Posted on 2025-04-07

4051 Kinesin Autoinhibition Requires Elbow Phosphorylation

Chen, G.; Guo, Z.; Zhu, Z.; Xie, S.; Zhou, T.; Ou, G.

10.1101/2024.10.07.616984 — cell biology — Posted on 2025-04-07

4052 Individuals with epilepsy and a history of comorbid depressive symptoms exhibit disrupted fronto-temporo-limbic connectivity during cognitive conflict encoding

Shekara, A.; Ross, A.; Soper, D. J.; Paulk, A. C.; Cash, S. S.; Widge, A. S.; Shear, P. K.; Sheehy, J. P.; Basu, I.

10.1101/2024.10.10.617540 — neuroscience — Posted on 2025-04-07

4053 First report of overwintering tadpoles in the endemic Italian agile frog Rana latastei

Melotto, A.; Melotto, A. S.; Ficetola, G. F.; Manenti, R.; Falaschi, M.

10.1101/2025.04.02.646811 — zoology — Posted on 2025-04-07

4054 Proterozoic Tectonic Drivers Underpin Flavobacterial Diversification

ZHANG, H.; Luo, H.

10.1101/2025.04.01.646730 — evolutionary biology — Posted on 2025-04-07

4055 Evolutionary plasticity of bacterial surface layer protein exoskeletons

Barwinska-Sendra, A.; Salgado, P. S.; Sendra, K. M.

10.1101/2025.04.02.646754 — evolutionary biology — Posted on 2025-04-07

4056 The Evolutionary Flexibility of the Drosophila Circadian Clock: Network Constraints or Adaptive Freedom?

Creasey, L. D.; Tauber, E.

10.1101/2025.04.02.646778 — evolutionary biology — Posted on 2025-04-07

4057 Application of environmental DNA-based assessment for upstream-downstream comparison of river macroinvertebrates in a metal-contaminated river

Uchida, N.; Iwasaki, Y.; Kuranishi, R.; Kondo, N. I.

10.1101/2025.04.02.646737 — ecology — Posted on 2025-04-07

4058 Immune phenotype-guided identification of disease-associated pathobionts in Crohn's disease

Nagao-Kitamoto, H.; Sugihara, K.; Kitamoto, S.; Ebihara, S.; Kim, Y.; Newman, K. L.; Alonso, U.; Suzuki, T.; Kioi, Y.; Yunesi, A.; Inohara, N.; Alteri, C. J.; Minar, P.; Denson, L. A.; Higgins, P.; Kao, J. Y.; Bishu, S.; Xie, Y.; Lei, Y. L.; Kamada, N.

10.1101/2025.04.01.646605 — immunology — Posted on 2025-04-07

4059 Tick-borne coinfections modulate CD8+ T cell response and progressive leishmaniosis

Scorza, B. M.; Pessoa-Pereira, D.; Pabon-Rodriguez, F.; Beasley, E. A.; Mahachi, K.; Cox, A. D.; Kontowicz, E.; Baccam, T.; Wilson, G.; Waugh, M. C.; Vollmer, S.; Toepp, A.; Raju, K.; Chigbo, O.; Elliff, J.; Becker, G.; Cyndari, K. I.; Tang, S.; Brown, G.; Petersen, C. A.

10.1101/2025.04.03.647089 — immunology — Posted on 2025-04-07

4060 Synthesizing human-specific spike-in standards for RNA-seq experiments and assessing their technical performance

Qin, R.; Fan, W.; Ding, F.; Wang, S.; He, B.; Hou, M.; Lin, Q.; Cui, P.; Liu, W.

10.1101/2025.04.01.646725 — bioinformatics — Posted on 2025-04-07

4061 Plasmidome-defensome interactions drive adaptation of 'Fervidacidithiobacillus caldus' in natural and industrial extreme acidic environments

Quatrini, R.; Pacheco-Acosta, S.; Castro-Toro, G.; Rojas-Villalobos, C.; Valenzuela, C.; Haristoy, J. J.; Zapata-Araya, A.; Moya-Beltran, A.; Sepulveda-Rebolledo, P.; Perez-Rueda, E.; Ulloa, R.; Giaveno, A.; Issotta, F.; Diez, B.; Beard, S.

10.1101/2025.04.02.646953 — genomics — Posted on 2025-04-07

4062 Haploinsufficiency of eNOS mitigates beneficial effects of maternal exercise on fetal heart development during pregestational diabetes

Van Neck, R.; Lu, X.; Wisse, L. J.; DeRuiter, M. C.; Feng, Q.

10.1101/2025.04.04.647329 — developmental biology — Posted on 2025-04-07

4063 Using CRISPR barcoding as a molecular clock to capture dynamic processes at single-cell resolution

Andres-Lopez, Y.; Santambrogio, A.; Kafetzopoulos, I.; Todd, C.; Alda-Catalinas, C.; Clark, S. J.; Reik, W.; Hernando-Herraez, I.

10.1101/2024.10.14.618192 — cell biology — Posted on 2025-04-07

4064 Hidden network preserved in Slide-tags data allows reference-free spatial reconstruction

Dahlberg, S. K.; Bonet, D. F.; Franzen, L.; Stahl, P. L.; Hoffecker, I. T.

10.1101/2024.06.16.598614 — bioinformatics — Posted on 2025-04-07

4065 DiffBreed: Automatic differentiation enables efficient gradient-based optimization of breeding strategies

Hamazaki, K.; Iwata, H.; Tsuda, K.

10.1101/2024.11.29.625951 — bioinformatics — Posted on 2025-04-07

4066 Annotating Hypothetical Proteins in Escherichia coli K-12

Chakraborty, S.; Ardern, Z.; Habibu, A.; Kaster, A. K.

10.1101/2025.03.20.643886 — bioinformatics — Posted on 2025-04-07

4067 Fleming: An AI Agent for Antibiotic Discovery in Mycobacterium Tuberculosis

Wei, Z.; Ektefaie, Y.; Zhou, A.; Negatu, D.; Aldridge, B. B.; Dick, T. B.; Skarlinski, M.; White, A.; Rodriques, S. G.; Hosseiniporgham, S.; Inna, K. V.; Sacchettini, J.; Zitnik, M.; Farhat, M. R.

10.1101/2025.04.01.646719 — bioinformatics — Posted on 2025-04-07

4068 Crosstalk between Proline Hydroxylation and Histidine Methylation Regulates Actin-Dependent Cell Mobility Control

Liu, Z.; Zi, Z.; Kim, C.; Wang, X.-D.; Yu, Y.

10.1101/2021.08.26.456853 — biochemistry — Posted on 2025-04-07

4069 Foot placement control underlies stable locomotion across species

De Comite, A.; Seethapathi, N.

10.1101/2024.09.10.612345 — animal behavior and cognition — Posted on 2025-04-07

4070 Mother-child dyadic interactions shape children's social brain and theory of mind

Li, L.; Xiao, J.; Zhao, W.; Zheng, Q.; Huang, X.; Shan, X.; Ming, Y.; Wang, P.; Wu, Z.; Chen, H.; Menon, V.; Duan, X.

10.1101/2024.09.23.614623 — neuroscience — Posted on 2025-04-07

4071 Probing the role of synaptic adhesion molecule RTN4RL2 in setting up cochlear connectivity

Karagulyan, N.; Überegger, M.; Qi, Y.; Babai, N.; Hofer, F.; Johnson Chacko, L.; Wang, F.; Luque, M.; Glueckert, R.; Schrott-Fischer, A.; Hua, Y.; Moser, T.; Bandtlow, C.

10.1101/2024.09.16.613011 — neuroscience — Posted on 2025-04-07

4072 Decoding Sequence-Structure-Function-Evolution of basic Leucine Zippers of Aureochromes from Heterokont Algae

Khamaru, M.; Bose, D.; Deb, A.; Mitra, D.

10.1101/2022.05.19.492614 — plant biology — Posted on 2025-04-07

4073 Gene traffic mediated by transposable elements shaped the dynamic evolution of ancient sex chromosomes of varanid lizard

Zhu, Z.; Dobry, J.; Wapstra, E.; Zhou, Q.; Ezaz, T.

10.1101/2025.04.01.646716 — evolutionary biology — Posted on 2025-04-07

4074 Recombination peaks and fast evolution

Crona, K.

10.1101/2025.03.06.641881 — evolutionary biology — Posted on 2025-04-07

4075 Cholesterol differentially modulates the activity of opioid and muscarinic receptors via common non-canonical binding site

Chetverikov, N.; Janouskova-Randakova, A.; Nelic, D.; Jakubik, J.

10.1101/2024.10.09.617372 — pharmacology and toxicology — Posted on 2025-04-07

4076 Visualizing nuclear pore complex plasticity with pan-Expansion Microscopy

Morgan, K. J.; Carley, E.; Coyne, A. N.; Rothstein, J. D.; Lusk, C. P.; King, M. C.

10.1101/2024.09.18.613744 — cell biology — Posted on 2025-04-07

4077 Multiplex base editing of BCL11A regulatory elements to treat sickle cell disease

Fontana, L.; Martinucci, P.; Amistadi, S.; FELIX, T.; MOMBLE, M.; TACHTSIDI, A.; CORRE, G.; Chalumeau, A.; Hardouin, G.; Martin, J.; Romano, O.; amendola, m.; Antoniou, P.; Miccio, A.

10.1101/2024.12.13.628398 — molecular biology — Posted on 2025-04-07

4078 Glycoengineering of the hepatitis C virus E2 glycoprotein leads to improved biochemical properties and enhanced immunogenicity

Kulakova, L.; Li, K. H.; Chiang, A. W. T.; Schwoerer, M. P.; Schoffelen, S.; Elkholy, K.; Chao, K. L.; Shahid, S.; Kumar, B.; Murray, N. B.; Archer-Hartmann, S.; Azadi, P.; Voldborg, B. G.; Marin, A.; Mariuzza, R. A.; Andrianov, A. K.; Ploss, A.; Lewis, N. E.; Toth, E. A.; Fuerst, T. R.

10.1101/2025.04.02.646860 — immunology — Posted on 2025-04-07

4079 Transcallosal generation of phase aligned beta-bursts underlies TMS-induced interhemispheric inhibition

Georgiev, C.; Mongold, S. J.; Cabaraux, P.; Naeije, G.; Duque, J.; Bourguignon, M.

10.1101/2024.11.22.624677 — neuroscience — Posted on 2025-04-07

4080 Cell type specific firing patterns in a V1 cortical column model depend on feedforward and feedback-driven states

Moreni, G.; Dorcioman, R.; Pennartz, C. M. A.; Mejias, J. F.

10.1101/2024.04.02.587673 — neuroscience — Posted on 2025-04-07

4081 Conserved energetic changes drive function in an ancient protein fold

Wells, M. L.; Lu, C.; Sultanov, D.; Weber, K. C.; Gong, Z.; Glasgow, A.

10.1101/2025.04.02.646877 — biophysics — Posted on 2025-04-07

4082 Rapid High-Resolution Analysis of Polysaccharide-Lignin Interactions via Proton-Detected Solid-State NMR with Application to Eucalyptus and Spruce

Xiao, P.; Yarava, J. R.; Debnath, D.; Sahu, P.; Xu, Y.; Xie, L.; Holmes, D.; Wang, T.

10.1101/2025.04.06.647447 — biophysics — Posted on 2025-04-07

4083 DeepCryoRNA: deep learning-based RNA structure reconstruction from cryo-EM maps

Li, J.; Chen, S.-J.

10.1101/2025.04.05.647396 — biophysics — Posted on 2025-04-07

4084 Lipid-Mediated Modulation of mGluR2 Embedded in Micelle and Bilayer Environments: Insights from Molecular Dynamics

Khodadadi, E.; Badiee, S. A.; Khodadadi, E.; Moradi, M.

10.1101/2025.04.06.647485 — biophysics — Posted on 2025-04-07

4085 High-dimensional mediation analysis to elucidate the role of metabolites in the association between PFAS exposure and reduced SARS-CoV-2 IgG in pregnancy

Guan, H.; Chen, J.; Kaur, K.; Amreen, B.; Lesseur, C.; Dolios, G.; Andra, S.; Narasimhan, S.; Pulivarthi, D.; Midya, V.; De Witte, L. D.; Bergink, V.; Rommel, A. S.; Petrick, L.

10.1101/2024.12.16.628663 — bioinformatics — Posted on 2025-04-07

4086 Stimulus-induced mechanical compaction of biological polymer networks via smart hydrogel microstructures

Salas-Quiroz, V.; Esch, K.; Zieske, K.

10.1101/2025.04.01.646676 — bioengineering — Posted on 2025-04-07

4087 FAK Differentially Mechanoregulates Cell Migration During Wound Closure

Patten, J.; Albeltagy, N.; Bonadio, J. D.; Ortez, A.; Wang, K.

10.1101/2025.04.01.646098 — bioengineering — Posted on 2025-04-07

4088 Global characterization of Dictyostelium discoideum gene expression changes under hypoxic conditions

Hesnard, J.; Gas-Pascual, E.; van der Wel, H.; Cochet-Escartin, O.; Joly, S.; Rieu, J.-P.; West, C. M.; Anjard, C.

10.1101/2025.04.02.646759 — genomics — Posted on 2025-04-07

4089 PERADIGM: Phenotype Embedding Similarity-based Rare Disease Gene Mapping

Zheng, W.; Xie, Y.; Gu, J.; Li, H.; Somlo, S.; Besse, W.; Zhao, H.

10.1101/2025.04.01.646670 — genetics — Posted on 2025-04-07

4090 Multi-omic analysis reveals the unique glycan landscape of the blood-brain barrier glycocalyx

Larsen, R.; Kucharz, K.; Aydin, S.; Micael, M. K. B.; Choudhury, B.; Paulchakrabarti, M.; Lonstrup, M.; Lin, D. C.; Abeln, M.; Muenster-Kuhnel, A.; Gomez Toledo, A.; Lauritzen, M.; Esko, J. D.; Daneman, R.

10.1101/2025.04.07.645297 — molecular biology — Posted on 2025-04-07

4091 Reproducible generation of Nipah virus pseudovirions with uniform expression of F and G surface glycoproteins for high-throughput neutralization assays

Varghese, G. R.; Vijay, V.; Sreedevi, S.; Lupitha, S. S.; Prabhakaran, P.; Aswathyraj, S.; Moorkoth, A. P.; Pulloor, N. K.; Sreekumar, E.

10.1101/2025.04.07.647518 — microbiology — Posted on 2025-04-07

4092 Predicting specificity of TCR-pMHC interactions using machine learning and biophysical models

Culka, M.; Lounsbury, N. W.; Thrift, W.; Nerli, S.; Wallace, A.; Nikolenyi, G.; Orlova, D.; Mukhyala, K.; AlQuraishi, M.

10.1101/2025.04.04.647165 — immunology — Posted on 2025-04-07

4093 Volume conductor models for magnetospinography

O'Neill, G. C.; Spedden, M. E.; Schmidt, M.; Mellor, S.; Stenroos, M.; Barnes, G. R.

10.1101/2024.11.04.621905 — neuroscience — Posted on 2025-04-07

4094 Ectopic, hepatic GLP-1R agonism enhances the weight loss efficacy of GLP-1 analogues.

Douros, J. D.; Capozzi, M.; Novikoff, A.; Mokrosinski, J.; DuBois, B.; Stock, J.; Rohlfs, R.; Anderson, M.; Jedrzejcyk, D. J.; Poulsen, S.; Blenke, E. O.; Dago, T.; Huus, K.; Kobberup, S.; Rivir, M.; Sorrell, J.; Mowery, S.; Drucker, D. J.; D'Alessio, D. A.; Campbell, J. E.; Muller, T. D.; Perez-Tilve, D.; Knerr, P. J.; Finan, B.

10.1101/2025.04.01.646483 — zoology — Posted on 2025-04-07

4095 Integrated tumour-immune cell response modelling of Luminal A breast cancer details malignant signalling and ST3Gal1 inhibitor induced reversal

Kaya, H. E.; Naidoo, K. J.

10.1101/2025.04.03.647001 — systems biology — Posted on 2025-04-07

4096 The Impact of Age and Sex on Cerebral and Large Artery Stiffness and the Response to Pulse Pressure

Choi, Y. D.; Kapadia, P.; Spiegel, J.; Cullen, A. E.; LaFarga, J.; Walker, A. E.

10.1101/2025.04.01.646687 — physiology — Posted on 2025-04-07

4097 Anomalous Thermoresponsive Phase Behavior in a Minimal Lattice Model Mimicking Proteins

Roy, S.; Santra, M.; Singh, R. S.

10.1101/2025.04.01.646641 — biophysics — Posted on 2025-04-07

4098 Chemical Compensation to Mechanical Loss in CellMechanosensation

Ni, Q.; Ge, Z.; Sen, A.; Wu, Y.; Fu, J.; Amitrano, A.; Srivastava, N.; Konstantopoulos, K.; Sun, S.

10.1101/2025.04.02.646640 — biophysics — Posted on 2025-04-07

4099 Breathe in, breathe out: Bacterial density determines collective migration in aerotaxis

Ghosh, D.; Chakrabarti, B.; Cheng, X.

10.1101/2025.04.02.646741 — biophysics — Posted on 2025-04-07

4100 Correlated Segments of Intrinsically Disordered Proteins as Drivers of Homotypic Phase Separation

Zhou, H.-X.

10.1101/2025.04.06.647444 — biophysics — Posted on 2025-04-07

4101 ECLARE: multi-teacher contrastive learning via ensemble distillation for diagonal integration of single-cell multi-omic data

Mann-Krzisnik, D.; Li, Y.

10.1101/2025.01.24.634799 — bioinformatics — Posted on 2025-04-07

4102 Integrative Multi-Omics Analysis of Melanoma: Uncovering Pathways Associated with Immunotherapy Outcomes

MacBeth, M. L.; Kaizer, A. M.; Wagner, B. D.; Couts, K.

10.1101/2025.04.01.646686 — bioinformatics — Posted on 2025-04-07

4103 Humpback whales harbor a highly novel and endemic gut microbiome that adapts to periods of fasting during migration

Bos, R.; Roman, J.; Fishbach, M.; Yin, S.; Gabriele, C.; Girguis, P.

10.1101/2025.04.03.647021 — genomics — Posted on 2025-04-07

4104 Targeting the ITGA3B1 Complex with A Novel Antibody-Drug Conjugate for Metastatic Bladder Cancer

Jung, H.; Lee, J.; Kim, E. G.; Ahn, J.; Haffner, M.; Nelson, P. S.; Kim, K.; Lee, J. K.; Yi, E. C.; Kim, K. M.

10.1101/2025.04.06.647354 — synthetic biology — Posted on 2025-04-07

4105 A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatin

Sternisha, A. C.; Li, H.; Traylor, J. I.; Guo, L.; Jun, J. H.; Zhao, X.; Gajendra, K.; Ouyang, Q.; Schmidt, M.; Fleishman, M.; Shi, D. D.; Savani, M. R.; Xiao, Y.; Lee, J. H.; Zacharias, L. G.; Mathews, T. P.; Gordillo, R.; Kim, Y. J.; Xu, L.; Doench, J. G.; Koduri, V.; Abdullah, K. G.; Banaszynski, L. A.; Agathocleous, M.; DeBerardinis, R. J.; Morrow, E. M.; McBrayer, S. K.

10.1101/2025.04.06.647450 — synthetic biology — Posted on 2025-04-07

4106 Steady-state neuron-predominant LINE-1 encoded ORF1p protein and LINE-1 RNA increase with aging in the mouse and human brain

Bonnifet, T.; Sinnassamy, S.; Massiani-Beaudoin, O.; Mailly, P.; Monnet, H.; Loew, D.; Lombard, B.; Servant, N.; Joshi, R. L.; Fuchs, J.

10.1101/2023.12.12.571308 — neuroscience — Posted on 2025-04-07

4107 Fast and memory efficient searching of large-scale mass spectrometry data using Tide

Kertesz-Farkas, A.; Acquaye, F. L. N. A.; Ostapenko, V.; Locon, R. H.; Lu, Y.; Grant, C. E.; Noble, W. S.

10.1101/2025.04.01.646675 — bioinformatics — Posted on 2025-04-07

4108 Surface Wetting Is a Key Determinant of α-Synuclein Condensate Maturation

Thrush, R. J.; Vadukul, D. M.; Allerton, S. C.; Storch, M.; Aprile, F. A.

10.1101/2024.06.06.597302 — biochemistry — Posted on 2025-04-07

4109 Zebra finch introductory notes do not influence female response to song and juvenile song learning accuracy

Kalra, S.; Chandolia, C.; Gautam, M.; Rajan, R.

10.1101/2025.04.06.647492 — animal behavior and cognition — Posted on 2025-04-07

4110 The GSA Family in 2025: A Broadened Sharing Platform for Multi-Omics and Multimodal Data

10.1101/2025.03.31.646270 — genomics — Posted on 2025-04-07

4111 ALGR: A multi-purpose agricultural landscape generator in R

Goldstein, E.; Deutscher, A.; O'Keeffe, E.; Wiegand, K.

10.1101/2025.03.31.646291 — ecology — Posted on 2025-04-07

4112 Aging-dependent dysregulation of EXOSC2 is maintained in cancer as a dependency

Skamagki, M.; Zhang, C.; Hacisuleyman, E.; Galleti, G.; Wu, C.; Vinagolu, R. K.; Cha, H.; Ata, D.; Kim, J.; Weiskittel, T.; Diop, M.; Aung, T.; Del Latto, M.; Kim, A. S.; Li, Z.; Miele, M.; Zhao, R.; Tang, L. H.; Hendrickson, R. C.; Romesser, P. B.; Smith, J. J.; Giannakakou, P.; Darnell, R. B.; Bott, M. J.; Li, H.; Kim, K.

10.1101/2025.04.04.647279 — cell biology — Posted on 2025-04-07

4113 Regulation of NTRK2 alternative splicing by PRPF40B controls neural differentiation and synaptic plasticity

Duarte-Ruiz, M.; Moreno-Castillo, A.; El Yousfi, Y.; Moreno-Castro, C.; Martinez-Martinez, N.; Jimenez-Lozano, S.; Kennel, M.; Ruiz-Rodriguez, C.; Rodriguez-Caparros, A.; Lopez-Ros, J.; de la Grange, P.; Hernandez-Munain, C.; Sune, C.

10.1101/2025.04.07.647526 — cell biology — Posted on 2025-04-07

4114 Identification of Wnt regulated genes that are repressed by, or independent of, β-catenin

Liu, S.; Haghani, S.; Petretto, E. G.; Madan, B.; Harmston, N.; Virshup, D. M.

10.1101/2025.04.06.647504 — cell biology — Posted on 2025-04-07

4115 Tn-seq of Thermus thermophilus genome reveals unexpected tolerance to insertions in bacterial common essential genes.

Gomez-Campo, C. L.; Gost, M.; Sousa de Silva, B. F.; Alvarez, L.; Berenguer, J.; Redrejo-Rodriguez, M.; Mencia, M.

10.1101/2025.04.03.647156 — microbiology — Posted on 2025-04-07

4116 HPV16 neutralizing monoclonal antibodies show evidence for common developmental pathways and public epitopes

Carter, J. J.; Hurlburt, N. K.; Scherer, E. M.; Singh, S.; Rodarte, J. V.; Smith, R. A.; Lewis, P.; Kinzelman, R. J.; Kieltyka, J.; Caban, M. E.; Wipf, G. C.; Pancera, M.; Galloway, D. A.

10.1101/2025.03.31.646278 — immunology — Posted on 2025-04-07

4117 Fast-spiking neurons in monkey orbitofrontal cortex underlie economic value computation

Murakawa, T.; Kawai, T.; Imaizumi, Y.; Yamada, H.

10.1101/2025.04.06.647503 — neuroscience — Posted on 2025-04-07

4118 Altered Neural Processing in Middle Frontal Gyrus and Cerebellum During Temporal Recalibration of Action-Outcome Predictions in Schizophrenia Spectrum Disorders

Schmitter, C. V.; Straube, B.

10.1101/2025.04.07.647511 — neuroscience — Posted on 2025-04-07

4119 Transcriptomic insights into early diagnosis of doxorubicin-induced cardiotoxicity in a rat model

Anca, E.; Pavel, I. O.; Licarete, E.; Rosioru, C.; Dobre, C.; Banciu, M.

10.1101/2025.04.01.646673 — pharmacology and toxicology — Posted on 2025-04-07

4120 Integrated single-cell and spatial multiomic analysis reveals widespread reactivation of developmental programs in diseased human hearts

Gao, W.; Hu, P.; Qiu, Q.; Kang, X.; Bedi, K.; Sasaki, K.; Margulies, K.; Wu, H.

10.1101/2025.04.01.646460 — genomics — Posted on 2025-04-07

4121 Potential Mechanisms Underlying Kaempferol-Promoted Osteoblast Proliferation and Osteogenic Differentiation: A Network Pharmacology and Experimental Validation Study

Wang, H. X.; LUO, Z.; ZHAO, C.; CHEN, D.; YAN, X.; GUAN, D.

10.1101/2025.04.02.646873 — cell biology — Posted on 2025-04-07

4122 Distinct cerebrospinal fluid DNA methylation signatures linked to Alzheimer's disease

Rados, M.; Klotz, S.; Regelsberger, G.; Stögmann, E.; Landegger, L. D.; Fetahu, I. S.

10.1101/2025.04.03.647115 — neuroscience — Posted on 2025-04-07

4123 Hepatic Yap1 activates systemic catabolism and muscle loss during organ repair: evidence for a liver-derived common mechanism with cancer cachexia.

HAMIDI, T.; Yang, Y.; Robinson, T. P.; Kronbergs, A.; Au, E.; Rupert, J. E.; Zhong, X.; Lal, S.; Liang, T.; Robling, A. G.; Hoggatt, A.; Carvalho, R.; Cury, S. S.; Wells, C.; Zimmers, T.; Koniaris, L. G.

10.1101/2025.04.01.646698 — physiology — Posted on 2025-04-07

4124 Real-time imaging of rotation during synthesis by the replisome

Retzer, T. M.; Rajappa, L. T.; Takahashi, M.; Hamdan, S. M.; Duderstadt, K. E.

10.1101/2025.04.01.646591 — biophysics — Posted on 2025-04-07

4125 Intratumor Heterogeneity Through the Lens of Gene Regulatory Networks

Rao, N.; Sapoval, N.; Zafar, H.; Nakhleh, L.

10.1101/2025.04.01.646625 — bioinformatics — Posted on 2025-04-07

4126 SAUNA - Simulated Annealing for Unique Nucleosome Arrangements from Cell-Free DNA-Sequencing Data

Lambrinos, M. R.; Rahimi, T.; Mehra, T.; Schmid, M. P.; Miglino, N.; Romanens, A.; Mertz, K. D.; Krauthammer, M.; Nienhold, R.; Wicki, A.; Balazs, Z.

10.1101/2025.04.01.646532 — bioinformatics — Posted on 2025-04-07

4127 Big Bones Mean Big Muscles: AI Quantifies 71 Individual Muscles Across the Whole Body, Revealing Widespread Links Between Muscle, Bone, and Body Size

Riem, L.; Pinette, M.; DuCharme, O.; Pabon, V.; Coggins, A.; Harold, L.; Costanzo, K. E.; Cousins, M.; Hein, R.; Rhodes, M.; Llevens, E.; Feng, X.; Benusa, S.; Breeding, T.; Derave, W.; Blemker, S. S.

10.1101/2025.04.01.646599 — bioengineering — Posted on 2025-04-07

4128 Insulin exerts epigenetic control of joint-specific memory T cells in rheumatoid arthritis

Chandrasekaran, V.; Erlandsson, M. C.; Svensson, D.; Malmhall-Bah, E.; Silfversward, S. T.; Katona, G.; Pullerits, R.; Bokarewa, M. I.

10.1101/2025.04.01.646580 — immunology — Posted on 2025-04-07

4129 Deep Learning-Driven Subtype Classification of Colorectal Cancer Using Histopathology Images for Personalized Medicine

Truong Le, T.; Nguyen-Truong, V.-T.; Trong Le Phan, N.; Duong Van Nhat, Q.; Fortune Mavuso, M.; Nguyen Thien Dao, P.; Ngoc Anh Nguyen, H.; Thuy Mai, T.; Thi Quang, K.

10.1101/2024.12.12.628270 — cancer biology — Posted on 2025-04-07

4130 Rapid label-free identification of seven bacterial species using microfluidics, single-cell time-lapse phase-contrast microscopy, and deep learning-based image and video classification

Hallstrom, E.; Kandavalli, V.; Wahlby, C.; Hast, A.

10.1101/2024.10.15.618380 — bioinformatics — Posted on 2025-04-07

4131 Stage-specific CAR-mediated signaling generates naive-like, TCR-null CAR T cells from induced pluripotent stem cells

Yoo, S. P.; Yuan, X.; Engstrom, C.; Chang, P. C.; Li, S.; Lathrop, L. E.; Lagosh, J. A.; Saripalli, S.; Azzun, A.; Calvanese, V.; Mikkola, H.; Seet, C. S.; Kohn, D. B.; Crooks, G. M.

10.1101/2024.11.25.624041 — bioengineering — Posted on 2025-04-07

4132 Molecular basis for multidrug efflux by an anaerobic RND transporter

Lawrence, R.; Athar, M.; Uddin, M. R.; Adams, C.; Sousa, J.; Durrant, O.; Lellman, S.; Sutton, L.; Keevil, C. W.; Patel, N.; Prosser, C.; McMillan, D.; Zgurskaya, H. I.; Vargiu, A. V.; Ahdash, Z.; Reading, E.

10.1101/2025.04.04.646765 — biochemistry — Posted on 2025-04-07

4133 Exploration and generation of cell transcriptomes over deep evolutionary time

Xu, Y.; Gatt, C.; Kaymak, E.; Kikuchi, K.; Bourguignon, T.; Zanini, F.

10.1101/2025.02.19.639005 — evolutionary biology — Posted on 2025-04-07

4134 Neural and Behavioral Changes in Older Adults from Auditory-Cognitive Training

Fisher, C.; Karunathilake, I. M. D.; Johns, M. A.; Vance, A.; Kuchinsky, S. E.; Anderson, S.; Simon, J. Z.

10.1101/2025.04.01.646593 — neuroscience — Posted on 2025-04-07

4135 Distorting anatomy to test MEG models and metrics

Lopez, J. D.; Balbastre, Y.; Ashburner, J.; Bonaiuto, J.; Barnes, G.

10.1101/2025.04.03.646622 — neuroscience — Posted on 2025-04-07

4136 Multi-modal brain properties are associated with interindividual differences in fear acquisition and extinction

Fraenz, C.; Metzen, D.; Packheiser, J.; Merz, C. J.; Selpien, H.; Axmacher, N.; Genc, E.

10.1101/2025.04.05.647350 — neuroscience — Posted on 2025-04-07

4137 Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus

Iannitelli, A. F.; Hassanein, L.; Tish, M. M.; Mulvey, B.; Blankenship, H.; Korukonda, A.; Liles, L. C.; Sharpe, A. L.; Pare, J.-F.; Villalba, R.; Segal, A.; Sloan, S. A.; Martinowich, K.; Dougherty, J. D.; McCann, K. E.; Smith, Y.; Beckstead, M. J.; Weinshenker, D.

10.1101/2023.03.07.530845 — neuroscience — Posted on 2025-04-07

4138 Bimodal genomic approach predicting Semaphorin 7A (SEMA7A) as prognostic biomarker in adrenocortical carcinoma

Dhall, A.; Taniyama, D.; Elloumi, F.; Luna, A.; Varma, S.; Kumar, S.; Escobedo, L.; Aladjem, M. I.; Redon, C. E.; Roper, N. I.; Reinhold, W. C.; Rivero, J. D.; Pommier, Y.

10.1101/2025.04.03.647086 — cancer biology — Posted on 2025-04-07

4139 Imputation Disparities Driven by Recent Selectionand Their Impact on Disease Risk Estimation in East and Southeast Asian Populations

Li, D.; Tangtanatakul, P.; Lei, Y.; Liu, X.; Huang, H.-Y.; Lin, Y.-C.-D.; Li, C.; Chen, Y.; Cai, L.; Zhao, J.; Pisitkul, P.; Suangtamai, T.; Yu, J.; Zhou, Y.; Kunhapan, P.; Sun, R.; Yu, G.; Sun, H.; Hirankarn, N.; Huang, H.-D.; Yang, W.; Wang, Y.-F.

10.1101/2025.04.03.646928 — genomics — Posted on 2025-04-07

4140 Revisiting the African mtDNA Landscape: A Continental Update from Complete Mitochondrial Genomes

Lankheet, I.; Chowdhury, A.; Tellgren-Roth, C.; Jolly, C.; Soares, A. E. R.; de Navascues, M.; Pacchiarotti, S.; Maselli, L.; Kouarata, G.; Donzo, J.-P.; Coetzee, V.; de Castro, M.; Ebbesen, P.; Priehodova, E.; Podgorna, E.; Cerny, V.; Green, S. T.; Harena, P.; Bakrobena, L.; Fomine, F. L. M.; Tolesa, Z. G.; Mengesh, W. A.; de Jongh, M.; Soodyall, H.; Bostoen, K.; Barbieri, C.; Larena, M.; Malmstrom, H.; Schlebusch, C. M.

10.1101/2025.04.05.647361 — evolutionary biology — Posted on 2025-04-07

4141 Effects of in vitro hemolysis and repeated freeze-thaw cycles in protein abundance quantification using the SomaScan and Olink assays

Candia, J.; Fantoni, G.; Moaddel, R.; Delgado-Peraza, F.; Shehadeh, N.; Tanaka, T.; Ferrucci, L.

10.1101/2024.09.21.613295 — molecular biology — Posted on 2025-04-07

4142 Longitudinal multimodal neuroimaging after traumatic brain injury

Radanovic, A.; Jamison, K. W.; Kang, Y.; Shah, S.; Kuceyeski, A.

10.1101/2025.04.04.647315 — neuroscience — Posted on 2025-04-07

4143 Spatiotemporal differences of GABAergic polarization and shunting during dendritic integration

Dembitskaya, Y.; Kirsanov, A.; Wu, Y.-W.; Brazhe, A.; Semyanov, A.

10.1101/2025.04.05.647352 — neuroscience — Posted on 2025-04-07

4144 Differential temperature adaptation mechanisms in the High Arctic-adapted Cerastium regelii Ostenf. and the widespread Stellaria longipes Goldie.

Lane, S. L.; Erland, L. A. E.

10.1101/2025.03.15.643465 — plant biology — Posted on 2025-04-07

4145 High doses of electromagnetic radiation pre- and post- fertilization produce different developmental outcomes in Xenopus laevis.

Mauricio, H.; Abreu, J. G.; Peshkin, L.

10.1101/2025.03.25.645254 — pharmacology and toxicology — Posted on 2025-04-07

4146 Alectinib enhances response to RBM39 degradation via SRPK1 inhibition

Ma, Y.; Poon, E.; Jin, C.; Martins da Costa, B.; Xu, Y.; Quazi, S.; Zourdoumis, N.; Wickremesinghe, C.; Chesler, L.; Keun, H. C.; Nijhuis, A.

10.1101/2025.03.28.644532 — cancer biology — Posted on 2025-04-07

4147 AQuaRef: Machine learning accelerated quantum refinement of protein structures

Zubatyuk, R.; Biczysko, M.; Ranasinghe, K.; Moriarty, N. W.; Gokcan, H.; Kruse, H.; Poon, B. K.; Adams, P. D.; Waller, M. P.; Roitberg, A. E.; Isayev, O.; Afonine, P. V.

10.1101/2024.07.21.604493 — biochemistry — Posted on 2025-04-07

4148 Evolution of the olfactory system during the radiation of Heliconiini butterflies

Toh, Y. P.; Cicconardi, F.; Bianchini, G.; Merrill, R. M.; Montgomery, S. H.

10.1101/2025.04.06.647427 — evolutionary biology — Posted on 2025-04-07

4149 Habitat use differences mediate population threat exposure in white sturgeon

Walter, J. A.; Singer, G. P.; Reuman, D. C.; Colborne, S. F.; Sheppard, L. W.; O'Donnell, D. R.; Coombs, N.; Tracy, E.; Johnston, M.; Miller, E. A.; Steel, A. E.; Kelly, J. T.; Fangue, N. A.; Rypel, A. L.

10.1101/2022.08.31.505999 — ecology — Posted on 2025-04-07

4150 The microtubule-binding protein EML3 is required for mammalian embryonic growth and cerebral cortical development; Eml3 null mice are a model of cobblestone brain malformation

Carrier, I.; Diez, E.; Piscopo, V. E. C.; Bechstedt, S.; van Bokhoven, H.; Srour, M.; Berghuis, A.; Stifani, S.; Yamanaka, Y.; McInnes, R. R.

10.1101/2025.04.06.647459 — developmental biology — Posted on 2025-04-06

4151 The Drosophila SPECC1L homolog, Split Discs, co-localizes with non-muscle myosin II and regulates focal adhesion dynamics.

Teran, A.; Jung, J.; Plantenkamp, A.; Pardini, A.; Zhao, A.; Chandramouli, S.; Jefferis, A.; Applewhite, D. A.

10.1101/2025.04.06.647460 — cell biology — Posted on 2025-04-06

4152 Resting-state alpha and mu rhythms change shape across development but lack diagnostic sensitivity for ADHD and autism

Bender, A.; Voytek, B.; Schaworonkow, N.

10.1101/2023.10.13.562301 — neuroscience — Posted on 2025-04-07

4153 Learning the cellular origins of cancer using single-cell chromatin landscapes

Bairakdar, M. D.; Giotti, B.; Lee, W.; Stancl, P.; Wagenblast, E.; Hambardzumyan, D.; Polak, P.; Karlic, R.; Tsankov, A.

10.1101/2025.04.06.646131 — cancer biology — Posted on 2025-04-06

4154 Super-Resolution Diffusivity Mapping Reveals Spatial Correlations Between Lateral Mobility and Structural Heterogeneities on Cellular Membranes

Han, C.; Zhao, Z.; Gao, H.; Deng, J.; Wang, Q.; Wang, Y.; Liu, L.; Xu, L.; Jiang, S.; Zhan, X.; Chen, K.; Yan, R.; Li, W.; Huang, W.; Xu, K.; Xiang, L.

10.1101/2025.04.01.646704 — biophysics — Posted on 2025-04-06

4155 PIP2-Tmie Interactions Drive Mammalian Hair Cell Slow Adaptation Independently of Myosin Motors

Caprara, G. A.; Kim, Y.; Jun, S.; Li, S.; Kim, U.; Shin, J.-B.; Peng, A. W.

10.1101/2025.04.01.646713 — biophysics — Posted on 2025-04-06

4156 Morphogen-driven melanin pathway dynamics regulated by Wnt1 and apontic-like underlie larval spot coloration in Bombyx mori

Yoda, S.

10.1101/2025.04.03.645855 — genetics — Posted on 2025-04-06

4157 Spatial Heterogeneity of Microbial Community Structure and Its Environmental Drivers in Surface Sediments of Erhai Lake

Xiong, H.-Q.; Yang, C.-g.; Bao, H.-R.; Qu, J.-Z.; Luan, Z.-X.; Sun, X.; Xiang, H.

10.1101/2025.04.01.646692 — ecology — Posted on 2025-04-06

4158 The functional organization of chromosome territories in single nuclei during zygotic genome activation

Shankar Ganesh, A.; Orban, T. M.; Raj, R.; Fatzinger, P. I.; Johnson, A.; Riccard, S. M.; Zhanaidarov, A.; Inaba, M.; Erceg, J.

10.1101/2025.04.06.647428 — developmental biology — Posted on 2025-04-06

4159 β-Arrestin Condensates Regulate G Protein-Coupled Receptor Function

Anderson, P.; Xiao, P.; Zhong, Y.; Kaakati, A.; Alfonso-DeSouza, J.; Zhang, T.; Zhang, C.; Qi, L.; Ding, W.; Liu, S.; Pani, B.; Krishnan, A.; Chen, O.; Jassal, C.; Strawn, J.; Sun, J.; Rajagopal, S.

10.1101/2025.04.05.647240 — cell biology — Posted on 2025-04-06

4160 Atelocollagen exhibits superior performance compared to growth factors in upregulating proteins associated with tendon healing

Park, S.-J.; Yoon, J. P.; Oh, K.-S.; Chung, S. W.

10.1101/2025.04.06.647440 — cell biology — Posted on 2025-04-06

4161 Prevalence of Campylobacter and non-typhoidal Salmonella along broiler chicken production and distribution networks, Vietnam

Xin, C.; Thi, T. H.; Duong, T. Q.; Nhat, T. T.; Pham, H. T. T.; Son, D. T. T.; Huong, L. Q.; Nhung, L. T. H.; Butt, S.; Hang, T. T. T.; Seow, K.; Hennessey, M.; Lehri, B.; Lam, C. T. A.; Gerber, P. F.; Conway, P. L.; Stabler, R. A.; Blake, D.; Tomley, F.; Pfeiffer, D.; Thi, N. P.; Fournie, G.; Conan, A.

10.1101/2025.04.03.647142 — microbiology — Posted on 2025-04-06

4162 Lack of Bcl6 promotes anti-tumor immunity by activating glycolysis to rescue CD8 T cell function

Nemazee, D.; Luan, F.; Li, Y.; Ning, J.; Tran, J. T.; Blane, T.; Bhargava, R.; Huang, Z.; Xiao, C.

10.1101/2025.04.01.646721 — immunology — Posted on 2025-04-06

4163 Deep Learning of Cellular Metabolic Flux Distributions Predicts Lifespan

Hilsabeck, T. A.; Rea, S. L.

10.1101/2024.11.22.623650 — systems biology — Posted on 2025-04-06

4164 Environmental dependence of colony morphologies in Labyrinthula species

Knight, J. M.; Gonzalez, P.; Fairhurst, D. J.; Melaugh, G.; Poon, W. C. K.

10.1101/2025.04.01.646626 — biophysics — Posted on 2025-04-06

4165 Bacterial motility patterns vary smoothly with spatial confinement and disorder

Zhang, H.; Wetherington, M. T.; Ko, H.; FitzGerald, C. E.; Luzzatto, L. V.; Kovacs, I. A.; Munro, E. M.; Nirody, J. A.

10.1101/2024.09.29.615714 — biophysics — Posted on 2025-04-06

4166 Unsupervised Whole-Genome Representation Learning Captures Bacterial Phenotypes

Dufault, C.; Moses, A. M.

10.1101/2025.04.01.646674 — bioinformatics — Posted on 2025-04-06

4167 SEHI-PPI: An End-to-End Sampling-Enhanced Human-Influenza Protein-Protein Interaction Prediction Framework with Double-View Learning

Yang, Q.; Fan, X.; Zhao, H.; Ma, Z.; Stanifer, M. L.; Bian, J.; Salemi, M.; Yin, R.

10.1101/2025.03.07.642105 — bioinformatics — Posted on 2025-04-06

4168 Enhancing variant detection in complex genomes: leveraging linked reads for robust SNP, Indel, and structural variant analysis

Luo, C.; Liu, Y. H.; Liu, H.; Zhang, Z.; Zhang, L.; Peters, B. A.; Zhou, X. M.

10.1101/2025.03.31.646392 — bioinformatics — Posted on 2025-04-06

4169 Optical Phenotyping Using Label-Free Microscopy and Deep Learning

Guan, S.; Knapp, T.; Duan, S.; Alfonso Garcia, A.; Sawyer, T. W.

10.1101/2025.04.01.646480 — bioengineering — Posted on 2025-04-06

4170 The Pseudomonas aeruginosa Membrane Histidine Kinase BqsS/CarS Directly Senses Environmental Ferrous Iron (Fe2+)

Paredes, A.; Iheacho, C.; Chacon, K. N.; Smith, A. T.

10.1101/2025.04.06.647434 — biochemistry — Posted on 2025-04-06

4171 Ecology and demographic structure of an extinct ibex population in Upper Palaeolithic Italian Alps

Armaroli, E.; Fontani, F.; Iacovera, R.; Cilli, E.; Latorre, A.; Luiselli, D.; Silvestrini, S.; Terlato, G.; Dalmeri, G.; Fontana, A.; Nannini, N.; Vonhof, H.; Calcagnile, L.; Quarta, G.; Duches, R.; Bortolini, E.; Cipriani, A.; Benazzi, S.; Lugli, F.; Romandini, M.

10.1101/2025.04.01.646553 — ecology — Posted on 2025-04-06

4172 VNC-Dist: A machine learning-based pipeline for quantification of neuronal positioning in the ventral nerve cord of C. elegans

Saharkhiz, S.; Petite, M.; Roenspies, T.; Perkins, T. J.; Colavita, A.

10.1101/2024.11.16.623955 — developmental biology — Posted on 2025-04-06

4173 IPPK-1 and IP6 contribute to ventral nerve cord assembly in C. elegans

Noblett, N.; Roenspies, T.; Flibotte, S.; Colavita, A.

10.1101/2024.03.03.583222 — developmental biology — Posted on 2025-04-06

4174 Lysophosphatidic acid controls autotaxin binding to 1-integrin: impact on disease progression in murine collagen-induced arthritis.

Emery, M.; Cuero, C. N.; Bouazza, L.; Internicola, C.; Duboeuf, F.; Cerecero-Aguirre, P.; McCarthy, A. A.; Machuca-Gayet, I.; Leblanc, R.; Peyruchaud, O.

10.1101/2025.04.04.646839 — cell biology — Posted on 2025-04-06

4175 BoltzDesign1: Inverting All-Atom Structure Prediction Model for Generalized Biomolecular Binder Design

Cho, Y.; Pacesa, M.; Zhang, Z.; Correia, B.; Ovchinnikov, S.

10.1101/2025.04.06.647261 — molecular biology — Posted on 2025-04-06

4176 Protein Secondary Structure Patterns In Short-Range Cross-Link Atlas

Vetrano, A.; Di Ianni, A.; Di Fonte, N.; Dell'Orletta, G.; Reale, S.; Daidone, I.; Iacobucci, C.

10.1101/2025.04.03.647081 — molecular biology — Posted on 2025-04-06

4177 Functional and structural characterization of AtAbf43C: An exo-1,5-α-L-arabinofuranosidase from Acetivibrio thermocellus DSM1313

Galindo, J. L.; Jeffrey, P. D.; Zhu, A.; Link, A. J.; Conway, J. M.

10.1101/2025.04.06.647456 — molecular biology — Posted on 2025-04-06

4178 ConSeqUMI, an error-free nanopore sequencing pipeline to identify and extract individual nucleic acid molecules from heterogeneous samples

Zahm, A. M.; Cranney, C. W.; Gormick, A. N.; Rondem, K. E.; Schmitz, B.; Himes, S. R.; English, J. G.

10.1101/2025.04.03.647077 — molecular biology — Posted on 2025-04-06

4179 Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity

Wassarman, D. R.; Pfaff, P.; Paulo, J. A.; Gygi, S. P.; Shokat, K. M.; Kranzusch, P. J.

10.1101/2025.04.06.647259 — microbiology — Posted on 2025-04-06

4180 REPOP: bacterial population quantification from platecounts

Pessoa, P.; Lu, C.; Tashev, S. A.; Kruithoff, R.; Shepherd, D. P.; Presse, S.

10.1101/2025.04.01.644179 — microbiology — Posted on 2025-04-06

4181 Microbial single-cell omics in situ

Lan, X.; Liang, Q.; He, J.; Wu, J.; Zhang, X.; Li, F.; Zhao, G.-P.; Guo, R.; Li, L.; Jia, H.

10.1101/2024.07.07.602369 — microbiology — Posted on 2025-04-06

4182 Synaptic plasticity facilitates oscillations in a V1 cortical column model with multiple interneuron types

Moreni, G.; Zou, L.; Pennartz, C. M. A.; Mejias, J. F.

10.1101/2023.08.27.555009 — neuroscience — Posted on 2025-04-06

4183 Fructose-2,6-bisphosphate restores TDP-43 pathology-driven genome repair deficiency in motor neuron diseases

Chakraborty, A.; Mitra, J.; Malojirao, V. H.; Kodavati, M.; Mandal, S. M.; Gill, S. K.; Sreenivasmurthy, S. G.; Vasquez, V.; Mankevich, M.; Krishnan, B.; Ghosh, G.; Hegde, M.; Hazra, T.

10.1101/2024.11.13.623464 — neuroscience — Posted on 2025-04-06

4184 The impact of dwell time on the contextual effect of visual and passive lead-in movements

Alvarez-Hidalgo, L.; Franklin, D. W.; Howard, I. S.

10.1101/2024.10.25.620176 — neuroscience — Posted on 2025-04-06

4185 Brain-derived estrogens facilitate male-typical behaviors by potentiating androgen receptor signaling in medaka

Nishiike, Y.; Maki, S.; Miyazoe, D.; Nakasone, K.; Kamei, Y.; Todo, T.; Ishikawa-Fujiwara, T.; Ohno, K.; Usami, T.; Nagahama, Y.; Okubo, K.

10.1101/2024.02.13.580203 — neuroscience — Posted on 2025-04-06

4186 Memory responses in visual cortex track recall success after single-trial encoding

Woodry, R.; Winawer, J.; Favila, S.

10.1101/2025.04.04.647327 — neuroscience — Posted on 2025-04-06

4187 In vivo cell-type and brain region classification via multimodal contrastive learning

Yu, H.; Lyu, H.; Xu, E. Y.; Windolf, C.; Lee, E. K.; Yang, F.; Shelton, A. M.; Olsen, S.; Minavi, S.; Winter, O.; The International Brain Laboratory, ; Dyer, E. L.; Chandrasekaran, C.; Steinmetz, N. A.; Paninski, L.; Hurwitz, C.

10.1101/2024.11.05.622159 — neuroscience — Posted on 2025-04-06

4188 Limited evidence for probabilistic cueing effects on grating-evoked event-related potentials and orientation decoding performance

den Ouden, C.; Kashyap, M.; Kikkawa, M.; Feuerriegel, D. C.

10.1101/2024.05.26.595980 — neuroscience — Posted on 2025-04-06

4189 Mechanistic basis for protection against fatty liver disease by CIDEB loss-of-function mutations

Zeng, Q.; Patel, S.; Wang, X.; Hsieh, M.-H.; Li, Z.; Ren, X.; Wang, J.; Kim, D.; Li, S.; Gu, X.; Mannino, G.; Maggiore, G.; Fang, X.; Li, L.; Zhu, M.; Wang, M.; Li, B.; Bellary, A.; Lim, K.; Qi, Z.; Pushpa, P.; Mandour, M. O.; Saudek, V.; Sharma, T.; Zhang, Y.; Hoxhaj, G.; Mishra, P.; Gopal, P.; Campbell, P.; Hoare, M.; Savage, D.; Zhu, H.

10.1101/2025.04.01.646492 — physiology — Posted on 2025-04-06

4190 GSK3B inhibition partially reverses brain ethanol-induced transcriptomic changes in C57BL/6J mice: Expression network co-analysis with human genome-wide association studies

gottlieb, s. A.; Zeliff, D.; O'Rourke, B.; Rogers, W. D.; Miles, M. F.

10.1101/2025.04.03.647116 — genomics — Posted on 2025-04-06

4191 Clinical and Genomic Characterization of Recalcitrant Enterococcal Bacteremia: A Multicenter Prospective Cohort Study (VENOUS)

Simar, S. R.; Tran, T. T.; Rydell, K. B.; Atterstrom, R. L.; Sahasrabhojane, P. V.; Dinh, A. Q.; Schettino, M. G.; Slanis, H. S.; Deyanov, A. E.; DeTranaltes, A. M.; Axell-House, D. B.; Miller, W. R.; Munita, J. M.; Tobys, D.; Seifert, H.; Biehl, L.; Zervos, M.; Suleyman, G.; Kaur, J.; Warzocha, V.; Cifuentes, R. O.; Abbo, L. M.; Shimose, L.; Liu, C.; Nguyen, K.; Miller, A.; Shelburne, S. A.; Arias, C. A.; Hanson, B. M.

10.1101/2025.04.01.645485 — genomics — Posted on 2025-04-06

4192 Joint profiling of 5mC, 5hmC, and the transcriptome in single cells identifies factors responsible for genome-wide DNA methylation erasure in human primordial germ cell maturation

Chialastri, A.; Heom, K. A.; Gell, J. J.; Hsu, F.-m.; Wamaitha, S. E.; Clark, A. T.; Dey, S. S.

10.1101/2025.04.01.646736 — genomics — Posted on 2025-04-06

4193 AMPK modulates a DEAH Box RNA-helicase to attenuate TOR signaling and establish developmental quiescence

Rashid, S.; Roy, R.

10.1101/2025.04.03.646977 — genetics — Posted on 2025-04-06

4194 An update to the global Critical Habitat layer

Dunnett, S.; Muge, A.; Ross, A.; Turner, J. A.; Burgess, N. D.; Jones, M. I.; Brooks, S.

10.1101/2025.04.01.646588 — ecology — Posted on 2025-04-06

4195 Paleogene mass extinction and ongoing Neogene recolonization shape the tropical African flora

Mellado-Mansilla, D.; Weigand, A.; Weigelt, P.; Kreft, H.; Kessler, M.

10.1101/2025.04.01.646671 — ecology — Posted on 2025-04-06

4196 DNA2 and MSH2 activity collectively mediate chemically stabilized G4 for efficient telomere replication

Fernandez, A.; Zhou, T.; Esworthy, S.; Shen, C.; Liu, H.; Hess, J. D.; Yuan, H.; Liu, N.; Shi, G.; Zhou, M.; Kosiyatrakul, S. T.; Gaur, V.; Sommers, J.; Edelman, W.; Li, G.-M.; Brosh, R.; Chai, W.; Lee, M. Y. W. T.; Zhang, D.; Zheng, L.; Shen, B.

10.1101/2025.04.04.647332 — molecular biology — Posted on 2025-04-06

4197 Therapeutic Potential of 20E in Pulmonary Arterial Hypertension: Involvement of Mas Receptor and PI3K/Akt Pathway

Lu, T.; Jia, W.; Wang, Y.; Ma, Y.; Du, F.; Gao, H.; Song, C.; Li, H.; Jin, X.; Liu, C.; Jin, H.; Lin, Y.

10.1101/2025.04.03.647130 — molecular biology — Posted on 2025-04-06

4198 TEAD1 is a novel regulator of NRF2 and oxidative stress response in cardiomyocytes

Jagannathan, R.; Lee, J.; De Vallance, E.; Negi, V.; Mandi, V.; Vyas, H.; Li, F.; Pagano, P. J.; Yechoor, V.; Moulik, M.

10.1101/2025.04.06.647438 — molecular biology — Posted on 2025-04-06

4199 Target-induced Argonaute-HNH filaments confer bacterial immunity

Kanevskaya, A.; Lisitskaya, L.; Moiseenko, A. V.; Sokolova, O. S.; Sluchanko, N. N.; Kulbachiskiy, A.

10.1101/2025.04.06.647449 — molecular biology — Posted on 2025-04-06

4200 The type I and III interferon responses restrict infection with tick-borne orthoflaviviruses through IFI6

Streicher, F.; Kenney, D.; Caval, V.; Chazal, M.; Aicher, S.-M.; Gracias, S.; Roesch, F.; Douam, F.; Jouvenet, N.

10.1101/2025.04.06.647422 — microbiology — Posted on 2025-04-06

4201 Anaerobic Bacteria in the Gut Microbiota Confer Colonization Resistance Against ESBL-Producing Escherichia coli in Mice

Murata, M.; Morinaga, Y.; Sasaki, D.; Yanagihara, K.

10.1101/2025.04.06.647462 — microbiology — Posted on 2025-04-06

4202 Statistical Characterization of Cortical-Thalamic Dynamics Evoked by Cortical Stimulation in Mice

Nigrisoli, D.; Russo, S.; Freddi, R.; Seseri, N.; Corti, S.; Ottoboni, L.; Barbieri, R.

10.1101/2025.04.04.647222 — neuroscience — Posted on 2025-04-06

4203 Opto-p53: A Light-Controllable p53 Signaling for Regulating p53-Dependent Cell Fate.

Tsuruoka, T.; Goto, Y.; Aoki, K.

10.1101/2025.04.04.647217 — synthetic biology — Posted on 2025-04-06

4204 Attenuative effect of Grifola frondosa (maitake mushroom) on severe DSS-induced colitis in vitamin D-deficient mice

Nishikawa, M.; Miyagi, R.; Kugimiya, Y.; Chudan, S.; Furusawa, Y.; Ikushiro, S.

10.1101/2025.04.04.647175 — biochemistry — Posted on 2025-04-06

4205 THA_1941 from Thermosipho africanus: A Thermostable β-1,3-Glucan Phosphorylase for Efficient β-1,3-Glucan Synthesis

Mao, G.; Yu, J.; Lin, J.; Song, M.; Su, Z.; Xie, H.; Zhang, H.; Chen, H.; Song, A.

10.1101/2025.04.05.647330 — biochemistry — Posted on 2025-04-06

4206 Comparative analysis of mammalian adaptive immune loci revealed spectacular divergence and common genetic patterns

Pospelova, M.; Voss, K.; Zamyatin, A.; Watson, C. T.; Koepfli, K.-P.; Pennell, M.; Safonova, Y.

10.1101/2025.04.01.646651 — genomics — Posted on 2025-04-06

4207 TOR signaling regulates GPCR levels on the plasma membrane and suppresses the Saccharomyces cerevisiae mating pathway

Leclerc, N. R.; Dunne, T.; Shrestha, S.; Johnson, C. P.; Kelley, J. B.

10.1101/2024.05.09.593412 — cell biology — Posted on 2025-04-06

4208 The effect of G-quadruplexes on TDP43 condensation, distribution, and toxicity

Oldani, E. G.; Reynolds Caicedo, K. M.; Spaeth Herda, M. E.; Sachs, A. H.; Chapman, E. G.; Kumar, S.; Linseman, D. A.; Horowitz, S.

10.1101/2024.04.30.591873 — molecular biology — Posted on 2025-04-06

4209 Novel in situ seeding immunodetection assay uncovers neuronal-driven alpha-synuclein seeding in Parkinson's disease

Alegre-Abarrategui, J.; Otero-Jimenez, M.; Wojewska, M. J.; Jogaudaite, S.; Miller, D.; Gray-Rodriguez, S.; Geoghegan, G. C.; Abelleira-Hervas, L.; Viney, T. J.; Sarkany, B.; Gveric, D.; Gentleman, S.

10.1101/2025.04.05.647370 — neuroscience — Posted on 2025-04-06

4210 A transgene harboring the human Glucose Transporter1 (GLUT1) gene locus ameliorates disease in GLUT1 deficiency syndrome model mice.

Tang, M.; Teng, S.; Kim, A. Y.; Peng, Y.; Monani, U. R.

10.1101/2025.04.05.647372 — neuroscience — Posted on 2025-04-06

4211 Dual Hypocretin Receptor Antagonism Reduces Oxycodone Seeking During Abstinence

Samson, K. R.; Bashford, A. R.; Espana, R. A.

10.1101/2025.04.05.647321 — neuroscience — Posted on 2025-04-06

4212 Incubation of oxycodone craving is associated with CP-AMPAR upregulation in D1 and D2 receptor-expressing medium spiny neurons in nucleus accumbens core and shell

Mount, K. A.; Kuhn, H. M.; Hwang, E.-K.; Beutler, M. M.; Wolf, M. E.

10.1101/2025.04.06.647399 — neuroscience — Posted on 2025-04-06

4213 Nonlinear integration of sensory and motor inputs by a single neuron in C. elegans.

Ray, A.; Gordus, A. G.

10.1101/2025.04.05.647390 — neuroscience — Posted on 2025-04-06

4214 A microbiome-derived transfer RNA modification underlies behavioral optimums and predator avoidance in mosquito larvae

Kelley, M.; Rathore, S.; Chandrasegaran, K.; Herbert, C.; Sabile, C. E. G.; Wood, T.; Joves, J.; Palacios, A.; Susanto, E.; Uhran, M.; Ramirez, A. L.; Chen, S.-C.; Singh, K.; Khalid, M. S.; Vinauger, C.; Buschbeck, E.; Limbach, P. A.; Benoit, J. B.

10.1101/2025.04.02.646203 — physiology — Posted on 2025-04-06

4215 Molecular dynamics simulations reveal a mechanism of calcium homeostasis driving homotrimerisation and heterotrimerization of type I collagen

Johnson, E.; de Souza, J. V.; Bronowska, A. K.; Laird, E. G.

10.1101/2025.04.03.646381 — biophysics — Posted on 2025-04-06

4216 A high-quality chromosome-level genome of an undescribed Meretrix species using Nanopore and Hi-C technologies

Chen, C.-C.; Hsu, T.-H.; Lu, H.-Y.; Tang, S.-L.; Ho, Y.-N.

10.1101/2025.04.01.646383 — genomics — Posted on 2025-04-06

4217 Sex Chromosome Turnover and Structural Interspecific Genome Divergence Shapes Meiotic Outcomes in Hybridizing Cobitis

Schlebusch, S.; Trifonov, V.; Halenkova, Z.; Klianitskaya, M.; Dedukh, D.; Ruiz Herrera, A.; Alvarez Gonzalez, L.; Pujol Infantes, G.; Hribova, E.; Andjel, L.; Bartos, O.; Pajer, P.; Tichopad, T.; Kulik, D.; Kotusz, J.; Dolezalkova-Kastankova, M.; Bohne, A.; Marta, A.; Horna, P.; Reifova, R.; Guiguen, Y.; Paces, J.; Janko, K.

10.1101/2025.04.01.646337 — genomics — Posted on 2025-04-06

4218 Invasion blurs the biphasic mosaic, amplifies the 'wicked problem' through impacts on avian distributions in montane habitats.

Jobin, V.; Harikrishnan, C. P.; Lele, A.; Joshi, V.; Chanda, R.; Lawrence, S.; Aravind, P. S.; Mubeen, M.; Joseph, M. R.; Subash, M.; Nandini, R.; Das, A.; Jathanna, D.; Robin, V.

10.1101/2025.04.03.646526 — ecology — Posted on 2025-04-06

4219 Integrating Behavioural Science and Epidemiology to Improve Early Detection of Zoonotic Swine Influenza in the Netherlands

Fraser, J.; Pacholewicz, E.; Hobbelen, P.; Hagenaars, T.; Bergevoet, R.; Counotte, M.

10.1101/2025.04.03.646521 — systems biology — Posted on 2025-04-06

4220 XPC loss-of-function triggers melanomagenesis through CDKN2A downregulation

Chelakkot, V. S.; Thomas, K.; Romigh, T.; Bernat, A.; Samuel, R.; Goli, N.; Rambhia, P.; Ravichandran, S.; Wang, Q.-E.; Cooper, K.; Funchain, P.; Ni, Y.; Arbesman, J.

10.1101/2025.04.03.646637 — cancer biology — Posted on 2025-04-06

4221 Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas

Ruiz, C. F.; Ge, X.; McDonnell, R.; Agabiti, S. S.; McQuaid, D. C.; Tang, A.; Kharwa, M.; Goodell, J.; Saavedra-Pena, R. d. M.; Wing, A.; Li, G.; Pinto Medicine, N.; Robert, M. E.; Varshney, R. R.; Rudolph, M. C.; Gorelick, F. S.; Wysolmerski, J. J.; Canals, D.; Haley, J.; Rodeheffer, M. S.; Muzumdar, M. D.

10.1101/2025.04.04.645324 — cancer biology — Posted on 2025-04-06

4222 Exploring shaped focused ion beams for lamella preparation

Brenner, J.; Plitzko, J. M.; Klumpe, S.

10.1101/2025.04.01.646235 — biophysics — Posted on 2025-04-06

4223 Scaling relations of multi-component phase coexistence boundaries

Qian, D.; Acker, J.; Scrutton, R.; Fischer, C. M.; Qamar, S.; Sneideris, T.; Borodavka, A.; Knowles, T.

10.1101/2025.04.02.645070 — biophysics — Posted on 2025-04-06

4224 SnoBIRD: A tool to identify C/D box snoRNAs and refine their annotation across all eukaryotes

Fafard-Couture, E.; Boulanger, C.; Faucher-Giguere, L.; Sinagoga, V.; Berthoumieux, M.; Hedjam, J.; Marcel, V.; Durand, S.; Bayfield, M. A.; Bachand, F.; Elela, S. A.; Jacques, P.-E.; Scott, M. S.

10.1101/2025.04.01.646650 — bioinformatics — Posted on 2025-04-06

4225 Genomic Insights into the Evolution of Carnivory in the Giant Butterwort, Pinguicula gigantea: Chromosome-Level Assembly and Phylogenomic Analysis

Albert, V. A.; Fleck, S. J.

10.1101/2025.04.05.646448 — genomics — Posted on 2025-04-06

4226 A new chromosome-level genome assembly for western painted turtle Chrysemys picta belli, a model for extreme physiological adaptations

Chen, J.; Bermingham, J. R.; Minx, P.; Kremitzky, M.; Lin, Z.; Warren, D. E.

10.1101/2025.04.01.646645 — genomics — Posted on 2025-04-06

4227 Chromosome-level genome assembly of Tamarindus indica

Singh, M.; Bisht, M. S.; G, A. M.; Mahajan, S.; Sharma, V. K.

10.1101/2025.04.01.646601 — genomics — Posted on 2025-04-06

4228 De novo genome assemblies of the dwarf honey bee subgenus Micrapis: Apis andreniformis and Apis florea

Ivancevic, A.; Sankovitz, M.; Allen, H.; Joyner, O.; Chuong, E. B.; Ramsey, S. D.

10.1101/2025.04.01.646657 — genomics — Posted on 2025-04-06

4229 Biological molybdenum usage stems back to 3.4 billion years ago

Klos, A.; Sobol, M.; Boden, J. S.; Stueeken, E. E.; Anderson, R. E.; Kurt O., K.; Kacar, B.

10.1101/2025.04.02.646658 — evolutionary biology — Posted on 2025-04-06

4230 Riparian Vegetation and Water Quality: A Case Study of Protected and Unprotected Rivers in the Atlantic Rainforest of Brazil

Lovegrove, A. L.; Dreyer, E.; le Breton, R.

10.1101/2025.04.01.646576 — ecology — Posted on 2025-04-06

4231 The Renowned Flavor Compound Cinnamaldehyde Induces Sweet Taste by Targeting the Transmembrane Domain of T1R3 in the Sweet Taste Receptor

Nakagita, T.; Itoigawa, A.; Okada, S.; Misaka, T.

10.1101/2025.04.03.643902 — molecular biology — Posted on 2025-04-06

4232 CDDO-Imidazole regulates RBC alloimmunization to the KEL antigen by activating Nrf2

Chang, C.-Y.; Hernandez-Armengol, R.; Paul, K.; Lee, J. Y.; Nance, K.; Shibata, T.; Yue, P.; Stehlik, C.; Gibb, D. R.

10.1101/2025.04.03.645598 — immunology — Posted on 2025-04-06

4233 A High-Performance and Recoverable DNA Origami Rotary Motor

Shapira, H.; Sheheade, B.; Basak, S.; Khara, D.; Nir, E.

10.1101/2025.04.04.645735 — biophysics — Posted on 2025-04-06

4234 SpatialAgent: An Autonomous AI Agent for Spatial Biology

Wang, H.; He, Y.; Coelho, P. P.; Bucci, M.; Nazir, A.; Chen, B.; Trinh, L.; Zhang, S.; Huang, K.; Chandrasekar, V.; Chung, D. C.; Hao, M.; Leote, A. C.; Lee, Y.; Li, B.; Liu, T.; Liu, J.; Lopez, R.; Tawaun, L.; Ma, M.; Makarov, N.; McGinnis, L.; Peng, L.; Ra, S.; Scalia, G.; Singh, A.; Tao, L.; Uehara, M.; Wang, C.; Wei, R.; Copping, R.; Rozenblatt-Rosen, O.; Leskovec, J.; Regev, A.

10.1101/2025.04.03.646459 — bioinformatics — Posted on 2025-04-06

4235 Implementation of an adaptive-optics assisted isoSTED nanoscope

Li, Y.; Lee, D.; Allgeyer, E. S.; Schroeder, L. K.; Tu, S.; Bewersdorf, J.; Hao, X.

10.1101/2025.04.02.645322 — bioengineering — Posted on 2025-04-06

4236 How the rhizosphere chemistry explains the effectiveness of radish in reclaiming legacy phosphorus compared to maize

Yusuf, Y. M.; Montanha, G. S.; Benghzial, K.; Pavinato, P. S.; Pereira de Carvalho, H. W.

10.1101/2025.04.06.647426 — plant biology — Posted on 2025-04-06

4237 Real-Time Quantitative PCR Method for Assessing Wheat Cultivars for Resistance to Zymoseptoria tritici

Adhikari, T. B.; Balaji, B.; Goodwin, S. B.

10.1101/2025.04.02.646880 — plant biology — Posted on 2025-04-06

4238 The transcription factor NO TRANSMITTING TRACT / WIP2 regulates cytokinin homeostasis in Arabidopsis

Diaz-Ramirez, D.; Demesa-Arevalo, E.; Duran-Medina, Y.; Becerra-Garcia, R. E.; Cruz-Valderrama, J. E.; Herrera-Ubaldo, H.; Chavez-Montes, R. A.; di Marzo, M.; Colombo, L.; Sagasser, M.; Simon, R.; Novak, O.; de Folter, S.; Marsch-Martinez, N.

10.1101/2025.04.03.645522 — plant biology — Posted on 2025-04-06

4239 Negligible effect of host DNA on metagenomic analysis enables microbial ecology investigation in historical samples

Ng, S.-K.; Gutaker, R.

10.1101/2025.04.05.647358 — plant biology — Posted on 2025-04-06

4240 Cell cycle follows pause and play mechanism in environment stress recovery in diverse plant species

Hazelwood, O. S.; Diehl, K. A.; Hollenbeck, V.; Herb, D.; Gallagher, J. P.; Ashraf, A.

10.1101/2025.04.02.646900 — plant biology — Posted on 2025-04-06

4241 Outer epidermal edges mediate cell-cell adhesion for tissue integrity in plants

Erguvan, O.; Heymans, A.; Atakhani, A.; Gascon, E.; Smith, R. S.; Ali, O.; Verger, S.

10.1101/2025.04.03.646819 — plant biology — Posted on 2025-04-06

4242 Convergent losses of arbuscular mycorrhizal symbiosis in carnivorous plants

Montero, H.; Freund, M.; Fukushima, K.

10.1101/2025.04.03.646726 — plant biology — Posted on 2025-04-06

4243 An unrecognized and crucial role of chloroplast division in leaf variegation in Arabidopsis thaliana

Wu, W.; Guo, W.; Zhu, H.; Li, D.; Zhang, Z.; Lin, D.; Qu, M.; Yu, Z.; Huang, J.

10.1101/2025.04.06.647415 — plant biology — Posted on 2025-04-06

4244 Welcome pathogens: transient heat dampens the responses to acibenzolar-S-methyl beyond defenses in apple plants

Chavonet, E.; Nguyen, B.-h.; Heintz, C.; Cournol, R.; Siroka, J.; Novak, O.; Larbat, R.; Gaucher, M.; Brisset, M.-N.; Pantin, F.; Degrave, A.

10.1101/2025.04.03.647103 — plant biology — Posted on 2025-04-06

4245 Prosystemin-derived signals: bridging leaf microbiome dynamics and defense activation

Castaldi, V.; Wicaksono, W. A.; De Filippis, F.; Berg, G.; Criscuolo, M. C.; Rao, R.

10.1101/2025.04.05.646382 — plant biology — Posted on 2025-04-06

4246 Transcriptional dynamics of nitrogen fixation and senescence in soybean nodules: A dual perspective on host and Bradyrhizobium regulation.

DelPercio, R.; McGregor, M.; Morley, S.; Nikaeen, N.; Meyers, B. C.; Gonzalez, P. B.

10.1101/2025.04.02.646848 — plant biology — Posted on 2025-04-06

4247 Simultaneous knockout of VITAMIN C DEFECTIVE 2 and 3 exacerbates ascorbate deficiency and light stress sensitivity

Tanaka, Y.; Maruta, T.; Arima, K.; Nakayama, H.; Ishikawa, T.

10.1101/2025.04.03.647133 — plant biology — Posted on 2025-04-06

4248 Serine activates defense mechanisms via glutamate receptor-like channel 3.4 and calcium-dependent protein kinase 5 signaling in plants.

Lee, K.; Navodani, A.; Camacho, J.; Yoo, H.

10.1101/2025.04.04.647287 — plant biology — Posted on 2025-04-06

4249 Loss-of-function of the drought-induced genes GASA3 and AFP1 confers enhanced drought tolerance in Arabidopsis thaliana

Bhattacharyya, S.; Turysbek, B.; Lorenz, S. D.; Rosales, D. C.; Shoaib, Y.; Gutbrod, K.; Doermann, P.; Chigri, F.; Vothknecht, U. C.

10.1101/2025.04.03.647048 — plant biology — Posted on 2025-04-06

4250 The chemistry and morphology of Vepris wadigo (Rutaceae) a new Endangered tree of Kenyan coastal forest with the description of wadigin, a newly named alkaloid.

Cheek, M.; Luke, W. R. Q.; Olaranont, Y.; Langat, M.

10.1101/2025.04.04.647269 — plant biology — Posted on 2025-04-06

4251 Temperature signals drive grass secondary cell wall thickening

Gregory, G. A.; Coomey, J. H.; Khahani, B.; Gonze, D.; Omran, S.; McGillivray, K. A.; Stewart, C. E.; Gardner, K. A.; Follette, D.; Hazen, S. P.

10.1101/2025.04.03.647122 — plant biology — Posted on 2025-04-06

4252 High Density Phenotypic Map of Natural Variation for Intermediate Phenotypes Associated with Stalk Lodging Resistance in Maize

Kunduru, B.; Bokros, N. T.; Tabaracci, K.; Kumar, R.; Brar, M. S.; Stubbs, C. J.; Oduntan, Y.; DeKold, J.; Bishop, R. H.; Woomer, J.; Verges, V. L.; McDonald, A.; McMahan, C. S.; DeBolt, S.; Robertson, D. J.; Sekhon, R.

10.1101/2025.04.03.647088 — plant biology — Posted on 2025-04-06

4253 GI-NemaTracker - A farm system-level mathematical model to predict the consequences of gastrointestinal parasite control strategies in sheep

Benson, L.; Kyriazakis, I.; Fox, N.; Howell, A.; Innocent, G. T.; Kenyon, F.; Williams, D.; Ewing, D. A.

10.1101/2025.04.01.646550 — systems biology — Posted on 2025-04-06

4254 Remote Phenotyping Strategies for Sunflower Flowering Assessments Using Deep Learning Approaches

Volpato, L.; Tirado Tolosa, S.; Potnuru, C.; Jaacks, J.; Layton, J.

10.1101/2025.04.03.646664 — plant biology — Posted on 2025-04-06

4255 Modeling the growth of cytosolic TDP-43 inclusion bodies and accumulated neurotoxicity of misfolded oligomers in neurons

Kuznetsov, A. V.

10.1101/2023.11.28.569118 — biophysics — Posted on 2025-04-06

4256 MeCP2 controls dendritic morphogenesis via miR-199a-mediated Qki downregulation

Irie, K.; Nakashima, H.; Yamaguchi, M.; Osakada, F.; Ozaki, N.; Tsujimura, K.; Nakashima, K.

10.1101/2025.04.04.642981 — neuroscience — Posted on 2025-04-06

4257 Dynamic sensitivity analysis of a mathematical model describing the effect of the macroalgae Asparagopsis taxiformis on rumen fermentation and methane production under in vitro continuous conditions

Blondiaux, P.; Kiesse, T. S.; Eugene, M.; Munoz-Tamayo, R.

10.1101/2024.06.19.599712 — systems biology — Posted on 2025-04-06

4258 Trichoderma afroharzianum T22 induces rhizobia and flavonoid-driven symbiosis to promote tolerance to alkaline-exposed iron deficiency in garden pea

Thapa, A.; Hasan, M. R.; Kabir, A. H.

10.1101/2024.07.11.603139 — plant biology — Posted on 2025-04-06

4259 Single-cell multi-omic analysis reveals principles of transcription-chromatin interaction during embryogenesis

Bhardwaj, V.; Griffa, A.; Gaza, H. V.; Zeller, P.; van Oudenaarden, A.

10.1101/2024.09.23.614335 — genomics — Posted on 2025-04-06

4260 Optimal antimicrobial dosing combinations when drug-resistance mutation rates differ

Delaney, O.; Letten, A. D.; Engelstaedter, J.

10.1101/2024.05.04.592498 — evolutionary biology — Posted on 2025-04-06

4261 Giant transposons promote strain heterogeneity in a major fungal pathogen

Gluck-Thaler, E.; Forsythe, A.; Puerner, C.; Gutierrez-Perez, C.; Stajich, J. E.; Croll, D.; Cramer, R. A.; Vogan, A. A.

10.1101/2024.06.28.601215 — microbiology — Posted on 2025-04-06

4262 Device encapsulated MSCs for adaptive secretome therapy to effectively target ischaemic heart injury

Kompa, A.; Greening, D.; Lees, J.; Kong, A. M.; Cross, J.; Nowland, A.; Phang, J.; Naghipour, S.; Deng, Y.; Darby, J. R.; Mariana, L.; Kos, C.; Hall, T.; Newcomb, A.; Chong, J. J.; Ritchie, R.; Morrison, J.; Papas, K.; Kelly, K.; Hausenloy, D.; Loudovaris, T.; Lim, S. Y.

10.1101/2025.04.01.646502 — pathology — Posted on 2025-04-06

4263 Improving hifiasm haplotypes for autopolyploid genome assemblies using constraint programming

Schiex, T.; Klopp, C.; Givry, S. d.; Durante, V.

10.1101/2025.04.01.646355 — bioinformatics — Posted on 2025-04-06

4264 Functional prediction of DNA/RNA-binding proteins using deep learning based on gene expression correlations

Osato, N.

10.1101/2025.03.03.641203 — bioinformatics — Posted on 2025-04-06

4265 Chemical Genomics Language Model toward Reliable and Explainable Compound-Protein Interaction Exploration

Koyama, T.; Tsumura, H.; Okita, R.; Yamazaki, K.; Hasegawa, A.; Imamura, K.; Kato, T.; Iwata, H.; Kojima, R.; Inoue, H.; Matsumoto, S.; Okuno, Y.

10.1101/2024.02.13.580100 — bioinformatics — Posted on 2025-04-06

4266 Forest conversion to cashew orchards delays the diel activity of diurnal mammals in West Africa

Palmeirim, A. F.; Na Mone, D.; Nhasse, I.; Soares, J.; Oliveira, R.; Lopes-Lima, M.; Palma, L.

10.1101/2025.04.01.646119 — ecology — Posted on 2025-04-06

4267 Secreted retropepsin-like enzymes are essential for stress tolerance and biofilm formation in Pseudomonas aeruginosa

Lormand, J. D.; Savelle, C. H.; Teschler, J. K.; Lopez, E.; Little, R. H.; Malone, J.; Yildiz, F. H.; Garcia-Garcia, M. J.; Sondermann, H.

10.1101/2025.03.18.643919 — microbiology — Posted on 2025-04-06

4268 Longitudinal trajectories of brain development from infancy to school age and their relationship to literacy development

Turesky, T. K.; Escalante, E.; Loh, M. Y.; Gaab, N.

10.1101/2024.06.29.601366 — neuroscience — Posted on 2025-04-06

4269 Transferring functional chromosomes between intergeneric yeast generates monochromosomal hybrids with improved phenotypes and widespread transcriptional responses

Lyu, Y.; Song, K.; Zhou, J.; Chen, H.; Li, X. C.; Yu, Y.; Lu, H.

10.1101/2025.01.24.634819 — synthetic biology — Posted on 2025-04-06

4270 Non-Invasive Quantification of Viability in Spheroids Using Deep Learning

Dubinsky, D.; Harel, S.; Bein, A.; Nyska, A.; Yaari, S.; Koc, B.; Anas, F.; Bentwich, I.; Wolf, L.

10.1101/2025.03.09.642246 — pharmacology and toxicology — Posted on 2025-04-06

4271 Learning interpretable representation for context-specific transcription regulatory networks using a foundation model

Yu, Z.; Yang, D.; Chen, Q.; Zhang, Y.; Li, Z.; Wang, Y.; Wang, C.; Zhang, Y.

10.1101/2025.03.29.646077 — bioinformatics — Posted on 2025-04-06

4272 From Understudied to Understood: The MiniENCODE Framework for Multi-Omics Analysis in Diverse Species

Yang, H.; Shan, Z.; Shang, H.; Jiang, P.; Li, Y.; Tu, Q.

10.1101/2024.01.06.573815 — genomics — Posted on 2025-04-06

4273 Lung architecture amplifies tissue deposition in an agent-based model of fibrotic development

Casey, D. T.; Sosa, A.; Mori, V.; Hall, J.; Suki, B.; Smith, B. J.; Bates, J. H. T.

10.1101/2025.04.01.646600 — systems biology — Posted on 2025-04-06

4274 Sorbitol uptake and oxygen transfer shape AOX1 promoter induction under methanol-free conditions in Komagataella phaffii lacking formate dehydrogenase

Bustos, C. V.; Cozmar, R. C.; Berrios, J.; Fickers, P.

10.1101/2025.04.01.646572 — bioengineering — Posted on 2025-04-06

4275 Single-Cell Multiomics Reveals Regulatory Mechanisms of CAR T Cell Persistence and Dysfunction in Multiple Myeloma

Jordana-Urriza, L.; Serrano, G.; Camara-Pena, S.; Calleja-Cervantes, M. E.; San Martin-Uriz, P.; Zabaleta, A.; Oliver-Caldes, A.; Espanol-Rego, M.; Alignani, D.; Lozano, T.; Rodriguez-Diaz, S.; Iglesias, E.; Cabanas, V.; Reguera, J. L.; Gonzalez-Calle, V.; Mateos, M. V.; Sanchez-Guijo, F.; Paiva, B.; Lasarte, J. J.; Inoges, S.; Lopez-Diaz de Cerio, A.; Gonzalez-Navarro, A.; Juan, M.; Fernandez de Larrea, C.; Tamariz, E.; Alfonso-Pierola, A.; Rodriguez-Otero, P.; San-Miguel, J.; Hernaez, M.; Rodriguez-Madoz, J. R.; Prosper, F.

10.1101/2025.04.01.646378 — genomics — Posted on 2025-04-06

4276 Essential role of hsa-miR-203a-3p in type I Interferons immune homeostasis during Influenza and NDV infection

Kumar, P.; Kumar, A.; Kumar, A.; Kumar, H.

10.1101/2025.04.01.646562 — immunology — Posted on 2025-04-06

4277 GPCR-targeted imaging and manipulation of homeostatic microglia in living systems

Vanaja Chandrasekharan, S.; Chaubey, P.; Khandelwal, S.; Medishetti, R.; Chakraborty, S.; Rajaram, S.; Jayakumar, K.; Latua, P.; Goyal, R.; R, G.; Das, S.; Chatti, K.; Mandal, K.; Tazhe Veetil, A.

10.1101/2025.04.01.646501 — immunology — Posted on 2025-04-06

4278 Intestinal fructose metabolism/GLP-1/β-cell axis counteracts hyperglycemia after short-term fructose ingestion

Murao, N.; Seino, Y.; Morikawa, R.; Hidaka, S.; Haraguchi, T.; Tomatsu, E.; Habara, M.; Ohno, T.; Yokoi, N.; Harada, N.; Hayashi, Y.; Yamada, Y.; Suzuki, A.

10.1101/2025.04.01.646509 — physiology — Posted on 2025-04-06

4279 High-throughput histopathology for complex in vitro models

10.1101/2025.04.01.646522 — pathology — Posted on 2025-04-06

4280 Attenuation of mosaic aneuploidy and erroneous first mitotic division of human embryos

Currie, C. E.; Byrska, A.; Taylor, D. M.; Erent, M.; Bakalova, D.; Sun, X.; Koki, C.; Burroughs, N.; Anderson, R.; Marston, A.; Hartshorne, G.; McAinsh, A.

10.1101/2025.04.05.647367 — cell biology — Posted on 2025-04-06

4281 Human-specific transposable elements shaped the evolution of craniofacial development through regulation of neural crest migration

Deelen, L.; Mitchell, Z. H.; Demurtas, M.; Garcia Del Valle, B.; Trizzino, M.

10.1101/2025.04.04.647334 — genomics — Posted on 2025-04-06

4282 Context modulates brain state dynamics and behavioral responses during narrative comprehension

Chen, Y.; Zada, Z.; Nastase, S. A.; Ashby, F. G.; Ghosh, S. S.

10.1101/2025.04.05.647323 — neuroscience — Posted on 2025-04-06

4283 A scoping study of the whole-cell imaging literature: a foundational corpus, potential for data-mining and research synthesis, and a call for standardization of an emerging field

Mirvis, M.; Weingard, B.; Goodman, S.; Marshall, W. F.

10.1101/2025.02.03.636363 — cell biology — Posted on 2025-04-05

4284 3' UTR variants of ALS-linked RNAs modify subcellular and cellular phenotypes

Savasan-Sogut, M.; Campos-Melo, D.; Strong, M. J.

10.1101/2025.04.05.647382 — molecular biology — Posted on 2025-04-05

4285 Screening of Natural Plant Extracts for Antimicrobial Activity Against Streptobacillus moniliformis

Singh, K. K.; Saini, M.; Prakash, D.

10.1101/2025.04.05.647341 — microbiology — Posted on 2025-04-05

4286 Hyperreflexia after corticospinal tract lesion reflects 1A afferent circuit changes not increased KCC2 hyperexcitability

Bethea, T.; Adegbenro, T.; Martin, J. H.

10.1101/2025.02.21.639555 — neuroscience — Posted on 2025-04-05

4287 Noninvasive ultrasound targeted modulation of calcium influx in splenic immunocytes potentiates antineoplastic immunity attenuating hepatocellular carcinoma proliferation

Dong, W.; Wang, G.; Li, S.; Chai, Y.; Wang, Q.; Li, Y.; Fei, Q.; Zong, Y.; Geng, J.; Liu, P.; Li, Z.

10.1101/2025.03.31.646454 — biophysics — Posted on 2025-04-05

4288 Robust conformational space exploration of cyclic peptides by combining different MD protocols and force fields

Murail, S.; Sawmynaden, J.; Zemirli, A.; Jusot, M.; Pietrucci, F.; Chomilier, J.; Tuffery, P.; Stratmann, D.

10.1101/2025.03.31.646350 — biophysics — Posted on 2025-04-05

4289 Refining filtering criteria for accurate taxonomic classification of ancient metagenomic data

Oskolkov, N.

10.1101/2025.03.31.646431 — bioinformatics — Posted on 2025-04-05

4290 Automated Quality Control of Time-Course Imaging from 3D in vitro cultures

Cramer, E.; Lopez-Vidal, T.; Johnson, J.; Wang, V.; Bergman, D.; Weeraratna, A.; Burkhart, R.; Fertig, E. J.; Zimmerman, J. W.; Heiser, L.; Chang, Y. H.

10.1101/2025.03.31.646437 — bioengineering — Posted on 2025-04-05

4291 Maximizing the fidelity of a photovoltaic subretinal prosthesis for human patients

Jensen, N.; Goldstein, A. K.; Ly, K.; Devaud, Q.; Palanker, D.

10.1101/2025.03.31.646451 — bioengineering — Posted on 2025-04-05

4292 Extremely Early Flowering and Large Grain Isogenic Japonica Rice Koshihikari Integrated with Gene e1 and GW2

Tomita, M.; Arai, K.

10.1101/2025.03.31.646432 — genomics — Posted on 2025-04-05

4293 Unexpected Molecular Mechanism of Orc6-Based Meier-Gorlin Syndrome: Insights from a Humanized Drosophila Model

Balasov, M.; Akhmetova, K.; Chesnokov, I.

10.1101/2025.03.31.646466 — genetics — Posted on 2025-04-05

4294 Investigation of the global transportation of Culicoides biting midges, vectors of livestock and equid arboviruses, from flower-packing plants in Kenya

Stokes, J.; Labuschagne, K.; Fevre, E. M.; Baylis, M.

10.1101/2025.04.01.646514 — ecology — Posted on 2025-04-05

4295 Using revisitation data for predicting changes in ecosystem functioning across protected and non-protected coastal dunes

La Bella, G.; Acosta, A. T. R.; Jucker, T.; Bazzichetto, M.; Andrello, M.; Sperandii, M. G.; Carboni, M.

10.1101/2025.03.31.646285 — ecology — Posted on 2025-04-05

4296 Haploinsufficiency of eNOS mitigates beneficial effects of maternal exercise on fetal heart development during pregestational diabetes

Van Neck, R.; Lu, X.; Wisse, L. J.; DeRuiter, M. C.; Feng, Q.

10.1101/2025.04.04.647329 — developmental biology — Posted on 2025-04-05

4297 The effect of MurM and a branched cell wall structure on penicillin resistance in Streptococcus pneumoniae

Gjennestad, R. S.; Heggenhougen, M. V.; Winther, A. R.; Moldstad, J.; Eldholm, V.; Kjos, M.; Haavarstein, L. S.; Straume, D.

10.1101/2025.04.05.647355 — microbiology — Posted on 2025-04-05

4298 Development of an Intranasally- and Intramuscularly-Administrable Replicon Vaccine Efficacious Against H5N1 Influenza Virus

McClary, W. D.; Brandt, D. S.; Jennewein, M. F.; Singh, J.; Beaver, S.; Ykema, M. R.; Press, C.; Melief, E.; Bakken, J.; Fusco, P.; Lo, E.; Battisti, P.; Cross, N.; Kasal, D. N.; Hartwig, A. T.; Casper, C.; Bowen, R. A.; Gerhardt, A.; Voigt, E. A.

10.1101/2025.03.31.646478 — immunology — Posted on 2025-04-05

4299 The classical MHC class I and II genes of O. m. formosanus exhibit different polymorphism levels

Zhang, Z.-W.; Fugmann, L. A.; Yang, S. Y.; Gwo, J.-C.; Fugmann, S. D.

10.1101/2025.03.31.646510 — immunology — Posted on 2025-04-05

4300 Endothelial cell Nrf2 controls neuroinflammation following a systemic insult

Zou, H.; Leah, T.; Huang, Z.; He, X.; Mameli, E.; Caporali, A.; Dando, O.; Qiu, J.

10.1101/2024.10.21.619507 — neuroscience — Posted on 2025-04-05

4301 Uniaxial force modifies the length of the mammary ductal network and the orientation of ducts during pubertal development: Findings from computational modeling and laboratory experiments

Ulloa, D.; Teeple, K. M.; Casey, T. M.; George, U. Z.

10.1101/2024.10.15.618498 — systems biology — Posted on 2025-04-05

4302 Deep Learning Predicts Survival Across Squamous Tumor Entities From H&E Stains: Insights from Head and Neck, Esophagus, Lung and Cervical Cancer

Bitto, V.; Jiang, X.; Baumann, M.; Kather, J. N.; Kurth, I.

10.1101/2025.03.31.646351 — pathology — Posted on 2025-04-05

4303 Protocell formation on micrometeorites

Jesorka, A.; Villalmanzo, E. P.; Ciftcioglu, E.; Jedrasik, P.; Larsen, J.; Gozen, I.

10.1101/2025.03.31.646313 — biophysics — Posted on 2025-04-05

4304 Integrating experimental feedback improves generative models for biological sequences

Calvanese, F.; Peinetti, G.; Pavlinova, P.; Nghe, P.; Weigt, M.

10.1101/2025.03.31.646327 — bioinformatics — Posted on 2025-04-05

4305 Unified integration of spatial transcriptomics across platforms

Haber, E.; Deshpande, A.; Ma, J.; Krieger, S.

10.1101/2025.03.31.646238 — bioinformatics — Posted on 2025-04-05

4306 Training data composition determines machine learning generalization and biological rule discovery

Ursu, E.; Minnegalieva, A.; Rawat, P.; Chernigovskaya, M.; Tacutu, R.; Sandve, G. K.; Robert, P. A.; Greiff, V.

10.1101/2024.06.17.599333 — bioinformatics — Posted on 2025-04-05

4307 Adjustable Compliance Footwear Technology to Investigate Gait Adaptation

Price, M.; Robbins, C.; Szemethy, S.; Abdikadirova, B.; Olson, G.; Hoogkamer, W.; Huber, M. E.

10.1101/2025.03.31.645746 — bioengineering — Posted on 2025-04-05

4308 pH-Sensitive Optical Nanocomposites Using Polymer-Coated Gold Nanorods

Chen, Y.; Li, X.

10.1101/2025.03.31.646487 — bioengineering — Posted on 2025-04-05

4309 Comparison of Urinary Proteome Modifications Between Methamphetamine-Abstinent Rehabilitation Patients for Over Three Months and Healthy Individuals

Chen, Y.; Shen, Z.; Liang, J.; Deng, Y.; Gao, Y.

10.1101/2025.04.02.646921 — biochemistry — Posted on 2025-04-05

4310 Single-cell RNA Sequencing Analysis of Sputum Cell Transcriptomes Reveals Pathways and Communication Networks That Contribute to the Pathogenesis of Asthma

Yan, X.; Liu, Q.; Adams, T. S.; Schupp, J. C.; Li, S.; Huang, S.; Grant, N.; Wilson, G.; Gomez, J. V.; Cohn, L.; Kaminski, N.; Weiss, S.; Tantisira, K.; Chupp, G. L.

10.1101/2025.03.31.646405 — genomics — Posted on 2025-04-05

4311 Reduced taurine transporter expression in lymphoblastoid cell lines from Alzheimer's disease patients compared with age-matched controls: Therapeutic implications?

Gavriel, Y.; Voinsky, I.; Klin, H.; Squassina, A.; Gurwitz, D.

10.1101/2025.03.31.646363 — genomics — Posted on 2025-04-05

4312 Unraveling the Genomic and Phylogenetic Complexity of the understudied microfungus Basidiobolus: Insights from 19 Newly Sequenced Genomes

Carleton, J. P.; Bradshaw, A. J.; Cleary, L. P.; Hincher, M. R.; Bushley, K. E.; Tabima, J. F.

10.1101/2025.03.31.646025 — genomics — Posted on 2025-04-05

4313 Understanding the Role of Toggle Genes in Chronic Lymphocytic Leukemia Proliferation

Sirbu, O.; Agarwal, G.; Giuliani, A.; Selvarajoo, K.

10.1101/2025.03.31.646494 — genomics — Posted on 2025-04-05

4314 Somatic mutations in ALS genes in the motor cortex of sporadic ALS patients

Gonzalez-Velasco, O.; Parlato, R.; Yilmaz, R.; Decker, L.; Menge, S.; Freischmidt, A.; Yang, X.; Tulasi, N.; Brenner, D.; Andersen, P. M.; Forsberg, K.; Schlachetzki, J. C. M.; Brors, B.; von Voithenberg, L. V.; Weishaupt, J. H.

10.1101/2025.03.31.646375 — genetics — Posted on 2025-04-05

4315 Disrupting Splicing Regulation to Rescue β-Catenin: A Novel Approach for Treating CTNNB1-Haploinsufficiency Disorder

Maruna, M.; Susjan Leite, P.; Mesko, M.; Jerala, R.

10.1101/2025.04.01.646581 — molecular biology — Posted on 2025-04-05

4316 30S-seq redefines the bacterial Ribosome Binding Site

Jagodnik, J.; Gherdol-Nouvion, V.; Al Sahmarani, M.; Maes, A.; Guillier, M.

10.1101/2025.04.04.647229 — molecular biology — Posted on 2025-04-05

4317 An integrative multi-omics approach points to membrane composition as a key factor in E. coli persistence

Canas-Duarte, S. J.; Sun, L.; Perez-Lopez, M. I.; Herrfurth, C.; Contreras, L. M.; Feussner, I.; Leidy, C.; Paulsson, J.; Riano-Pachon, D. M.; Pedraza, J. M.; Restrepo, S.

10.1101/2020.08.28.271171 — microbiology — Posted on 2025-04-05

4318 Multi-Omics and Machine Learning-Based Profiling of Severity Signatures in Mycoplasma Pneumoniae Infection in Children

Li, G.; Wang, W.; Hu, Z.; Yang, Q.; He, L.; Gao, Y.; Lai, X.

10.1101/2025.04.05.647347 — microbiology — Posted on 2025-04-05

4319 Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex

10.1101/2025.02.13.638205 — microbiology — Posted on 2025-04-05

4320 Wheat fiber-induced peripheral regulatory T-cells suppress development of colitis

Kim, S. E.; Abo, H.; Wang, Y.; Winer, S.; Winer, D.; Pellizzon, M.; Ngo, V. L.; Gewirtz, A.

10.1101/2025.03.31.646427 — immunology — Posted on 2025-04-05

4321 Characterizing PET CT patterns and bacterial dissemination features of tuberculosis relapse in the macaque model

Maiello, P.; Diedrich, C. R.; Rutledge, T.; Rodgers, M.; Kracinovsky, K.; Borish, H. J.; White, A. G.; Hopkins, F.; Chao, M. C.; Klein, E.; Fortune, S. M.; Flynn, J. L.; Lin, P. L.

10.1101/2025.03.31.646419 — immunology — Posted on 2025-04-05

4322 Low-Dimensional Representations of Visuomotor Coordination in Natural Behavior

Keshava, A.; Waechter, M. A.; Bosse, F.; Schueler, T.; Koenig, P.

10.1101/2024.03.30.587357 — neuroscience — Posted on 2025-04-05

4323 Intradental mechano-nociceptors serve as sentinels that prevent tooth damage

Ronan, E. A.; Gandhi, A. R.; Uchima Koecklin, K. H.; Hu, Y.; Wan, S.; Constantinescu, B. S. C.; Guenther, M. E.; Nagel, M.; Liu, L.-Y.; Jha, A.; Dakhilalla, L.; Blumberg, K. J.; Berthaume, I. T.; Stern, T.; Pipe, K. P.; Ye, B.; Li, P.; Emrick, J. J.

10.1101/2024.05.11.593684 — neuroscience — Posted on 2025-04-05

4324 Restoration of Susceptibility of blaNDM-bearing Escherichia. coli to Carbapenem Antibiotics by Exogenous N-acetylcysteine

Li, D.; Zhao, Y.; Guo, X.; Li, C.; Sun, Y.; Wang, Y.; Chang, L.; Wang, X.; Wang, Y.; Schwarz, S.; Du, X.-D.

10.1101/2025.03.31.646374 — pharmacology and toxicology — Posted on 2025-04-05

4325 ANALYSIS OF PHYTOEXTRACTS OF MEDICINAL PLANTS FOR ANTIMICROBIAL ACTIVITY AGAINST PATHOGENIC STRAINS OF MICROORGANISMS

Chokheli, V. A.; Butenko, E. V.; Pokudina, I. O.; Firsova, I. M.; Azarov, A. S.; Belyaev, M. O.; Tsymerskaia, C. A.; Sushkova, S. N.

10.1101/2025.03.31.646455 — pharmacology and toxicology — Posted on 2025-04-05

4326 Human blood vessel organoids recapitulate key mechanisms of transition from vasculopathy to fibrosis in systemic sclerosis

Xiao, Y.; Hong, X.; Zhi, L.; Li, Y. N.; Regensburger, M.; Marxreiter, F.; Gorg, B.; Koziel, S.; Gyorfi, A. H.; Filla, T.; Bruch, P. M.; Tripal, P.; Adjaye, J.; Dietrich, S.; Winkler, J.; Distler, J. H. W.; Matei, A. E.

10.1101/2025.03.31.646441 — biophysics — Posted on 2025-04-05

4327 Crystallographic fragment screening of the dengue virus polymerase reveals multiple binding sites for the development of non-nucleoside antiflavivirals

Saini, M.; Aschenbrenner, J. C.; Ruiz, F. X.; Chopra, A.; Chandran, A. V.; Marples, P. G.; Balcomb, B. H.; Fearon, D.; von Delft, F.; Arnold, E.

10.1101/2025.03.31.646453 — biophysics — Posted on 2025-04-05

4328 SCORCH2: a generalised heterogeneous consensus model for high-enrichment interaction-based virtual screening

Chen, L.; Blay, V.; Ballester, P. J.; Houston, D. R.

10.1101/2025.03.31.646332 — bioinformatics — Posted on 2025-04-05

4329 FootprintCharter: unsupervised detection and quantification of footprints in single molecule footprinting data

Barzaghi, G.; Krebs, A. R.; Zaugg, J. B.

10.1101/2025.03.31.646464 — bioinformatics — Posted on 2025-04-05

4330 SpaceBF: Spatial coexpression analysis using Bayesian Fused approaches in spatial omics datasets

Seal, S.; Neelon, B.

10.1101/2025.03.29.646124 — bioinformatics — Posted on 2025-04-05

4331 Dissecting Opioid Effects in Cell-Cell Communication Within the Ventral Tegmental Area

Chen, Y.; Ho, W.-Z.; Wei, Z.

10.1101/2025.03.31.646196 — bioinformatics — Posted on 2025-04-05

4332 PEAS: Detection of Clustered Differences in Genomic Data

Skola, D. D.; Glass, C.

10.1101/2025.03.31.646436 — bioinformatics — Posted on 2025-04-05

4333 Injectable adhesive hydrogel-drug complexes synchronize the release of chemoimmunotherapy to treat brain tumors in mice

Dion, M. Z.; Cryer, A. M.; Dahis, D.; Dosta, P.; Li, A.; Poley, M.; Puigmal, N.; Ling, I.; Carrasco, S.; Hinojosa, A.; Soria, Y.; Tyler, B.; Brem, H.; Artzi, N.

10.1101/2025.03.31.646388 — bioengineering — Posted on 2025-04-05

4334 Identification and Validation of Small Molecules with Mucin-Selective Regiospecific Binding in the Gastrointestinal Tract

Subramanian, D. A.; Kirtane, A. R.; White, G. N.; Freitas, D. E.; Ishida, K.; Jenkins, J.; Pettinari, A.; Morimoto, J.; Fitzgerald, N.; Traverso, G.

10.1101/2025.03.31.646052 — bioengineering — Posted on 2025-04-05

4335 Integrating affinity chromatography in the platform process for Adenovirus purification

Wu, Y.; Barbieri, E.; Smith, W.; Minzoni, A.; Kilgore, R.; Chu, W.; Daniele, M.; Menegatti, S.

10.1101/2025.03.31.646491 — bioengineering — Posted on 2025-04-05

4336 Human endogenous retrovirus K (HERV-K) envelope structures in pre- and post-fusion by Cryo-EM

Shek, J.; Sun, C.; Wilson, E. M.; Moadab, F.; Hastie, K. M.; Rajamanickam, R. R.; Penalosa, P. J.; Harkins, S. S.; Parakh, D.; Hariharan, C.; Zyla, D. S.; Yu, C.; Shaffer, K. C. L.; Lewis, V. I.; Avalos, R. D.; Mustelin, T.; Ollmann Saphire, E.

10.1101/2025.04.04.647320 — biochemistry — Posted on 2025-04-05

4337 Linoleic acid metabolite, 13-S-hydroxyoctadecadienoic acid, suppresses cancer cell growth by inhibiting mTOR

Park, S. J.; Kwon, H.; Yang, A. Y.; Lee, B.; Lee, H.; Park, S. E.; Lee, S.; Park, B. B.; Kim, Y.; Lee, J.; Oh, B.-C.; Deredge, D.; Wintrode, P. L.; Kim, M.-Y.; Byun, Y.; Kim, S.

10.1101/2025.04.02.646927 — biochemistry — Posted on 2025-04-05

4338 Structural basis of human replisome progression into a nucleosome

Steinruecke, F.; Markert, J. W.; Farnung, L.

10.1101/2025.04.04.647053 — molecular biology — Posted on 2025-04-05

4339 The Mismatch Negativity compared: EEG, SQUID-MEG and novel 4Helium-OPMs

Gutteling, T. P.; Mattout, J.; Daligault, S.; Jung, J.; Labyt, E.; Schwartz, D.; Lecaignard, F.

10.1101/2025.04.04.647154 — neuroscience — Posted on 2025-04-05

4340 Shedding dynamics of a DNA virus population during acute and long-term persistent infection

Blois, S.; Goetz, B. M.; Mojumder, A.; Sullivan, C. S.

10.1101/2025.03.31.646279 — pathology — Posted on 2025-04-05

4341 Mechanical Stress dissipation in locally folded epithelia is orchestrated by calcium waves and nuclear tension changes

Brun-Cosme-Bruny, M.; Pernet, L.; Elias, K.; Guilluy, C.; Oddou, C.; Dolega, M. E.

10.1101/2025.04.04.647200 — developmental biology — Posted on 2025-04-05

4342 Optimization of culture and transfection methods for primary snake cells

Kuriyama, S.; Shigematsu, K.; Kwon, S. J.; Kuwata, R.; Atsuta, Y.

10.1101/2025.04.04.647168 — developmental biology — Posted on 2025-04-05

4343 Epidermal Resident Memory T Cell Fitness Requires Antigen Encounter in the Skin

Weiss, E. S.; Hirai, T.; Li, H.; Liu, A.; Baker, S.; Magill, I.; Gillis, J.; Zhang, Y. R.; Ramcke, T.; Kurihara, K.; The ImmGen Consortium OpenSource T cell Project, ; Masopust, D.; Anandasabapathy, N.; Singh, H.; Zemmour, D.; Mackay, L. K.; Kaplan, D. H.

10.1101/2025.03.31.646438 — immunology — Posted on 2025-04-05

4344 A transcriptomic comparison of the HD10.6 human sensory neuron-derived cell line with primary and iPSC sensory neurons

Al-Abbasi, Z.; Bhuiyan, S.; Renthal, W.; Molliver, D. C.

10.1101/2025.04.03.643725 — neuroscience — Posted on 2025-04-05

4345 Theoretical physical color gamuts define luminosity and naturalness perceptual limits in natural scenes

Duay, K.; Nagai, T.

10.1101/2025.04.04.647230 — neuroscience — Posted on 2025-04-05

4346 A mechanism linking dopamine's roles in reinforcement, movement and motivation

Hamilos, A. E.; Wijsman, I. C.; Ding, Q.; Assawaphadungsit, P.; Ozcan, Z.; Assad, J. A.

10.1101/2025.04.04.647288 — neuroscience — Posted on 2025-04-05

4347 Large-scale 3D EM connectomics dataset of mouse hippocampal area CA1

Corteze, M.; Grasso, E.; Vezir, M.; Schmidt, H.

10.1101/2025.04.04.647285 — neuroscience — Posted on 2025-04-05

4348 Cortical markers of PAS-induced long-term potentiation and depression in the motor system: A TMS-EEG Registered Report

Arrigoni, E.; Bolognini, N.; Pisoni, A.; Guidali, G.

10.1101/2025.04.03.647045 — neuroscience — Posted on 2025-04-05

4349 Loudness and sound category: Their distinct roles in shaping perceptual and physiological responses to soundscapes

Erfanian, M.; Oberman, T.; Chait, M.; Kang, J.

10.1101/2025.04.04.647310 — neuroscience — Posted on 2025-04-05

4350 Residue-level structural information from isotope-edited FTIR spectroscopy reveals distinct molecular structures of different amyloid-β42 oligomers

Vosough, F.; Carstensen, S. M.; Baronio, C. M.; Barth, A.

10.1101/2025.03.31.646305 — biophysics — Posted on 2025-04-05

4351 Cumulating MS Signal enables polyclonal antibody analysis

Gueto-Tettay, C. A.; Strobaek, J.; Tang, D.; Gomez Toledo, A.; Karami, Y.; Khakzad, H.; Malmstrom, J.; Malmstrom, L.

10.1101/2025.03.31.645874 — bioinformatics — Posted on 2025-04-05

4352 Optimal foraging for simple organisms, the single-input marginal valuetheorem

Orjollet--Lacomme, T.; Friedman, J.; Perez-Escudero, A.

10.1101/2025.04.04.647000 — animal behavior and cognition — Posted on 2025-04-05

4353 Complement C3 Deficiency Enhances Renal Leptospiral Load and Inflammation While Impairing T Cell Differentiation During Chronic Leptospira interrogans Infection

Midon, L. M.; Duarte Neto, A. N.; Goncalves, A. M. M.; Henemann, M. B.; Kundu, S.; Gomes-Solecki, M.; Isaac, L.

10.1101/2025.03.31.646275 — immunology — Posted on 2025-04-05

4354 Unbiased Population-Based Statistics to Obtain Pathologic Burden of Injury after Experimental TBI

Smith, G.; Santana-Gomez, C. E.; Staba, R.; Harris, N. G.

10.1101/2025.04.03.647083 — neuroscience — Posted on 2025-04-05

4355 Reverse Double-Dipping: When Data Dips You, Twice--Stimulus-Driven Information Leakage in Naturalistic Neuroimaging

Kim, S.-G.

10.1101/2025.04.01.646146 — neuroscience — Posted on 2025-04-05

4356 Ethologically relevant behavioural assay for investigating reach and grasp kinematics during whole-body motor control in mice

Black, C. J.; Browne, L. E.; Brownstone, R. M.; Koch, S. C.

10.1101/2025.04.04.647225 — neuroscience — Posted on 2025-04-05

4357 Neuronal expression of S100B triggered by oligomeric Aβ peptide protects against cytoskeletal damage and synaptic loss

Saavedra, J.; Nascimento, M.; Figueira, A. J.; Oliveira da Silva, M. I.; Giao, T.; Oliveira, J.; Liz, M. A.; Gomes, C. M.; Cardoso, I.

10.1101/2025.04.04.647260 — neuroscience — Posted on 2025-04-05

4358 Transcriptional downregulation of rhodopsin is associated with desensitization of rods to light-induced damage in a murine model of retinitis pigmentosa.

Takita, S.; Harikrishnan, H.; Miyagi, M.; Imanishi, Y.

10.1101/2025.04.03.646684 — neuroscience — Posted on 2025-04-05

4359 Listening to the room: disrupting activity of dorsolateral prefrontal cortex impairs learning of room acoustics in human listeners

Hernandez-Perez, H.; Mikiel-Hunter, J.; Traer, J.; Monaghan, J.; Sowman, P.; McAlpine, D.

10.1101/2025.04.04.644835 — neuroscience — Posted on 2025-04-05

4360 The Arousal-Regulated Filter: Modulating Feedforward and Recurrent Dynamics for Adaptive Neural Tracking

Howlett, J. R.

10.1101/2025.03.31.646280 — neuroscience — Posted on 2025-04-05

4361 PrPC-induced signaling in human neurons activates phospholipase Cγ1 and an Arc/Arg3.1 response

Ojeda-Juarez, D.; Funk, G.; Richards, E.; Rajic, A. J.; McClatchy, D. B.; Soldau, K.; Chen, X.; Yates, J. R.; Gonias, S. L.; Sigurdson, C. J.

10.1101/2025.04.01.645054 — neuroscience — Posted on 2025-04-05

4362 Modeling dynamic inflow effects in fMRI to quantify cerebrospinal fluid flow

Ashenagar, B.; Gomez, D. E. P.; Lewis, L. D.

10.1101/2025.04.03.647027 — neuroscience — Posted on 2025-04-05

4363 Generative Approaches to Kinetic Parameter Inference in Metabolic Networks via Latent Space Exploration

Choudhury, S.; Toumpe, I.; Gabouj, O.; Hatzimanikatis, V.; Miskovic, L.

10.1101/2025.03.31.646317 — systems biology — Posted on 2025-04-05

4364 A novel rat model for human Meibomian gland dysfunction and ocular rosacea

Zhu, L.; Rodrigues-Braz, D.; Gelize, E.; Crepin, M.; Peltier, C.; Lheure, C.; Morel, X.; Bourges, J.-L.; Berdeaux, O.; Behar-Cohen, f.; ZHAO, M.

10.1101/2025.03.31.646002 — pathology — Posted on 2025-04-05

4365 The Effects of DMSO on DNA Conformations and Mechanics

Storm, K. R.; Korosy, C.; Skoruppa, E.; Pritzl, S. D.; Kolbeck, P. J.; Vanderlinden, W.; Schiessel, H.; Lipfert, J.

10.1101/2025.03.31.646418 — biophysics — Posted on 2025-04-05

4366 NeSyDPP4-QSAR: A Neuro-Symbolic AI Approach for Potent DPP-4-Inhibitor Discovery in Diabetes Treatment

Hossain, D.; Chen, J. Y.

10.1101/2025.03.31.646336 — bioinformatics — Posted on 2025-04-05

4367 Hexapods shift to increasingly stable gaits when climbing on inclined substrates

Riiska, C. A.; Harrison, J. S.; Thompson, R. D.; Nina, J. Q.; Gallice, G. R.; Rieser, J. M.; Bhamla, S.

10.1101/2025.04.04.647231 — animal behavior and cognition — Posted on 2025-04-05

4368 RNA Editors Sculpt the Transcriptome During Terminal Erythropoiesis

Han, A.; Yermalovich, A.; Najia, M. A. T.; Pearson, D. S.; Fujiwara, Y.; Bolgov, M.; Kubaczka, C.; North, T. E.; Lundin, V.; Orkin, S.; Daley, G. Q.

10.1101/2025.04.03.647020 — developmental biology — Posted on 2025-04-05

4369 Contribution of S1pr1-featured astrocyte subpopulation to cisplatin-induced neuropathic pain

Li, Y.; Squillace, S.; Schafer, R.; Giancotti, L. A.; Chen, Z.; Egan, T. M.; Hoft, S. G.; DiPaolo, R. J.; Salvemini, D.

10.1101/2025.04.03.642851 — neuroscience — Posted on 2025-04-05

4370 A Tonotopic Regulatory Axis Governing Isoform-Specific MYO7A Expression in Cochlear Hair Cells

Li, S.; Jun, S.; Kim, Y.; Gogineni, A.; Lee, F.; Kim, C. H.; Kim, U.-K.; Peng, A. W.; Shin, J.-B.

10.1101/2025.04.04.647241 — neuroscience — Posted on 2025-04-05

4371 An engine for systematic discovery of cause-effect relationships between brain structure and function

Luppi, A. I.; Milisav, F. I.; Suarez, L. E.; Shafiei, G.; Vohryzek, J.; Sanz Perl, Y.; Ali, H.; Rosas, F. E.; Mediano, P. A. M.; Misic, B.; Deco, G.; Kringelbach, M. L.

10.1101/2025.04.05.647237 — neuroscience — Posted on 2025-04-05

4372 Functional synaptic connectivity of engrafted spinal cord neurons with locomotor circuitry in the injured spinal cord

Tucker, A.; Eisdorfer, J. T.; Thackray, J. K.; Vo, K.; Thomas, H.; Tandon, A.; Moses, J.; Singletary, B.; Gillespie, T.; Smith, A.; Pauken, A.; Nadella, S.; Pitonak, M.; Letchuman, S.; Jang, J.; Totty, M.; Jalufka, F. L.; Aceves, M.; Adler, A. F.; Maren, S.; Blackmon, H.; McCreedy, D. A.; Abraira, V. E. G.; Dulin, J. N.

10.1101/2025.04.05.644402 — neuroscience — Posted on 2025-04-05

4373 Associations between fluid biomarkers and PET imaging (UCB-J) of synaptic pathology in Alzheimer's disease

Nilsson, J.; Mecca, A.; Ashton, N. J.; Salardini, E.; Odell, R.; Carson, R.; Benedet, A.; Blennow, K.; Zetterberg, H.; Van Dyck, C.; Brinkmalm, A.

10.1101/2025.03.31.646290 — neuroscience — Posted on 2025-04-05

4374 Cell-to-cell signalling mediated via CO2: activity dependent CO2 production in the axonal node opens Cx32 in the Schwann cell paranode.

Butler, J.; Mott, L.; Brown, A.; Dale, N.

10.1101/2025.04.04.647196 — neuroscience — Posted on 2025-04-05

4375 A persistent increase in gut permeability correlates with emotional dysregulation following maternal separation in male and female mice.

Castro-Zavala, A.; Nieto-Nieves, A.; Melgar-Locatelli, S.; Medina-Rodriguez, L.; Manas-Padilla, M. C.; Castilla-Ortega, E.

10.1101/2025.04.04.647178 — neuroscience — Posted on 2025-04-05

4376 Novel Approaches to Track Neurodegeneration in Murine Models of Alzheimer's Disease Reveal Previously Unknown Aspects of Extracellular Aggregate Deposition

Gallardo, D.; Steward, O.

10.1101/2025.04.04.647232 — neuroscience — Posted on 2025-04-05

4377 Structured interactions explain the absence of keystone species in synthetic microcosms

Pearl Mizrahi, S.; Lee, H.; Goyal, A.; Owen, E.; Gore, J.

10.1101/2025.03.31.646297 — systems biology — Posted on 2025-04-05

4378 Exploration of individual beta cell function over time in vivo: effects of hyperglycemia and glucagon-like peptide-1 receptor (GLP1R) agonism

Delgadillo, L.; Salazar, S.; Lopez-Noriega, L.; Provencher-Girard, A.; Larouche, S.; Prat, A.; Rutter, G. A.

10.1101/2025.03.31.646461 — physiology — Posted on 2025-04-05

4379 GM1 and GD3 Gangliosides Attenuate NGF-TrkA and BDNF-TrkB Signaling Dysfunction Associated with Acute Diisopropylfluorophosphate Exposure in Mouse Brain

Itokazu, Y.; Beck, W. D.; Terry, A. V.

10.1101/2025.03.31.646417 — pharmacology and toxicology — Posted on 2025-04-05

4380 MAPK Signaling and Angiopoietin-2 Contribute to Endothelial Permeability in Capillary Malformations

Nasim, S.; Baig, M.; Wylie-Sears, J.; Vivero, M.; Smits, P.; Marrs, L.; Cheng, Y. S.; Alves, C.; Pinto, A.; Greene, A. K.; Bischoff, J.

10.1101/2025.03.31.646063 — pathology — Posted on 2025-04-05

4381 Domain Coupling in Allosteric Regulation of SthK Measured Using Time-Resolved Transition Metal Ion FRET

Eggan, P.; Gordon, S. E.; Zagotta, W. N.

10.1101/2025.03.31.646362 — biophysics — Posted on 2025-04-05

4382 Sustained learned immunosuppression could not prevent local allergic ear swelling in a rat model of contact hypersensitivity

Salem, Y.; Leisengang, S.; Jakobs, M.; Dombrowski, K.; Bihorac, J.; Heiss-Lueckemann, L.; Wenzlaff, S.; Trautmann, L.; Hagenacker, T.; Schedlowski, M.; Hadamitzky, M.

10.1101/2025.04.05.647348 — animal behavior and cognition — Posted on 2025-04-05

4383 The Chromosome 19 miRNA Cluster Guards Trophoblasts Against Overacting Innate Immunity

Mouillet, J.-F.; Ouyang, Y.; Sadovsky, E.; Kothandan, V. K.; Sorenson, H. L.; Badeau, L. J.; Sarkar, S. N.; Chu, T.; Sorkin, A.; Sadovsky, Y.

10.1101/2025.04.03.647038 — developmental biology — Posted on 2025-04-05

4384 Haploinsufficiency of eNOS mitigates beneficial effects of maternal exercise on fetal heart development during pregestational diabetes

Van Neck, R.; Lu, X.; Wisse, L. J.; DeRuiter, M. C.; Feng, Q.

10.1101/2025.04.04.647329 — developmental biology — Posted on 2025-04-05

4385 Designed Soluble Notch Agonist Drives Human Ameloblast Maturation for Tooth Regeneration

PATNI, A. P.; Mout, R.; Moore, R.; Alghadeer, A. A.; Daley, G. Q.; Baker, D.; Mathieu, J.; Ruohola-Baker, H.

10.1101/2025.04.03.646929 — developmental biology — Posted on 2025-04-05

4386 Teeth Outside the Jaw: Evolution and Development of the Toothed Head Clasper in Chimaeras

Cohen, K. E.; Fraser, G. J.; Coates, M. I.

10.1101/2025.04.04.647311 — developmental biology — Posted on 2025-04-05

4387 G-quadruplex profiling in complex tissues using single-cell CUT&Tag

Lyu, J.; Hetey, S.; Castelo-Branco, G.; Bartosovic, M.; Elsässer, S. J.

10.1101/2025.04.03.647101 — developmental biology — Posted on 2025-04-05

4388 Comprehensive 3D imaging of whole zebrafish using a water-based clearing reagent for hard tissues

Taimatsu, K.; Prevedel, J.; Castranova, D.; Inoue, K.; Puthan, A.; Weinstein, B. M.

10.1101/2025.04.04.647305 — developmental biology — Posted on 2025-04-05

4389 The bone marrow niche and hematopoietic system are distinctly remodeled by CD45-targeted astatine-211 radioimmunotherapy

Hagen, M. W.; Setiawan, N. J.; Dexter, S. L.; Woodruff, K. A.; Gaerlan, F. K.; Orozco, J. J.; Termini, C. M.

10.1101/2025.04.04.645037 — cell biology — Posted on 2025-04-05

4390 Obesity promotes urinary tract infection by disrupting urothelial immune defenses

Schwartz, L.; Salamon, K.; Simoni, A.; Cotzomi-Ortega, I.; Sanchez-Zomora, Y.; Linn-Peirano, S.; John, P.; Ruiz-Rosado, J. d. D.; Jackson, A. R.; Wang, X.; Spencer, J. D.

10.1101/2025.04.04.647270 — cell biology — Posted on 2025-04-05

4391 Phenylhydrazone-based Endoplasmic Reticulum Proteostasis Regulator Compounds with Enhanced Biological Activity

Kline, G. M.; Boinon, L.; Guerrero, A.; Kutseikin, S.; Cruz, G.; Williams, M. P.; Paxman, R. J.; Balch, W. E.; Kelly, J. W.; Mu, T.; Wiseman, L.

10.1101/2025.04.04.646800 — cell biology — Posted on 2025-04-05

4392 Integrin-TGFβ axis induces partial EMT in basal-like cells to lead collective invasion

El-Gammal, A.; Jansen, L.; Verhagen, M. P.; Kremer, H.; Soufi, S.; Masoudnia, M.; Westland, D.; Bult, P.; Fodde, R.; Verstegen, M. M. A.; Gloerich, M.; van Mil, S. W. C.; Khalil, A. A.

10.1101/2025.04.04.647177 — cell biology — Posted on 2025-04-05

4393 Excitation Spectral Phasor Microscopy (ExSPM) unveils spatiotemporal heterogeneities in polarity of intracellular lipid droplets

Liu, J.; He, Y.; Yan, R.; Yan, J.; Wang, R.; Zhang, Z.; Xia, J.; Kireev, I.; Xu, K.; Chen, K.

10.1101/2025.04.03.647137 — cell biology — Posted on 2025-04-05

4394 β-Arrestin Condensates Regulate G Protein-Coupled Receptor Function

Anderson, P.; Xiao, P.; Zhong, Y.; Kaakati, A.; Alfonso-DeSouza, J.; Zhang, T.; Zhang, C.; Qi, L.; Ding, W.; Liu, S.; Pani, B.; Krishnan, A.; Chen, O.; Jassal, C.; Strawn, J.; Sun, J.; Rajagopal, S.

10.1101/2025.04.05.647240 — cell biology — Posted on 2025-04-05

4395 The N-terminal Segment of the Human ANKZF1 negatively regulates its internal mitochondrial targeting signal to prevent its mitochondrial localization

Ali, M.; Maheswaran, B.; Sahu, D.; Malhotra, N.; Mapa, K.

10.1101/2025.04.04.647180 — cell biology — Posted on 2025-04-05

4396 Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth by promoting tracheogenesis

Huang, K.; Miao, T.; Dantas, E.; Han, M.; Hu, Y.; Wang, K.; Sanford, J.; Goncalves, M.; Perrimon, N.

10.1101/2025.04.04.647255 — cell biology — Posted on 2025-04-05

4397 Smart hybrid microscopy for cell-friendlydetection of rare events

Stepp, W. L.; Durmus, E. B.; Rodriguez Alvarez, S. N.; Landoni, J. C.; Tortarolo, G.; Douglass, K. M.; Weigert, M.; Manley, S.

10.1101/2025.04.04.647219 — cell biology — Posted on 2025-04-05

4398 Loofah, a newly characterized adhesion protein, suppresses cell death in long-lived Drosophila hindgut enterocytes

Sawyer, J. K.; Montague, R. A.; Goddard, L.; Chakraborty, A.; Belato, P. B.; Fox, D. T.

10.1101/2025.04.04.647274 — cell biology — Posted on 2025-04-05

4399 Tubulin isotypes contribute opposing properties to balance anaphase spindle morphogenesis

Nsamba, E. T.; Bera, A.; Todi, V.; Savoy, L.; Gupta, R. M.; Gupta, M. L.

10.1101/2025.04.04.647290 — cell biology — Posted on 2025-04-05

4400 Dynamic transcriptional heterogeneity in pituitary corticotrophs

Yuan, Z.; Laiho, L.; Smith, E.; McDougall, C.; Duncan, P. J.; Le Tissier, P.; Shipston, M. J.; Romano, N.

10.1101/2025.04.04.645979 — cell biology — Posted on 2025-04-05

4401 Remodeling of RNA-Binding Proteome and RNA-mediated regulation as a new layer of control of sporulation

Kabore, T.; Belghazi, M.; Verthuy, C.; Galinier, A.; Delan-Forino, C.

10.1101/2025.03.21.644579 — microbiology — Posted on 2025-04-05

4402 Automated sleep scoring in hibernating and non-hibernating American black bears

Toien, O.; Pittaras, E. C.; Huang, Y.-G.; Brodersen, P. J. N.; Allocca, G.; Barnes, B. M.; Heller, H. C.

10.1101/2025.03.31.646262 — neuroscience — Posted on 2025-04-05

4403 Genetic risk in endolysosomal network genes correlates with endolysosomal dysfunction across neural cell types in Alzheimer's disease

Mamde, S.; Rose, S.; Prater, K. E.; Cochoit, A.; Lin, Y. F.; Smith, I.; Johnson, C. S. C.; Reid, A.; Qiu, W.; Strohbehn, S.; Keene, C. D.; Rolf, B.; Lin, K.; Lee, S.-I.; Garden, G.; Blue, E.; Young, J. E.; Jayadev, S.

10.1101/2025.03.16.643481 — neuroscience — Posted on 2025-04-05

4404 DNA Specimen Preservation using DESS and DNA Extraction in Museum Collections: A Case Study Report

Ogiso-Tanaka, E.; Shimada, D.; Ogawa, A.; Ishiyama, G.; Okumura, K.-i.; Hosaka, K.; Ishii, C.; Nam, K.-O.; Hoshino, M.; Nomura, S.; Kakizoe, S.; Nakamura, Y.; Nishiumi, I.; Ito, M. A.; Kitayama, T.; Tanaka, N.; Hosoya, T.; Jinbo, U.

10.1101/2025.03.30.646169 — zoology — Posted on 2025-04-05

4405 Cellular dynamics under time-varying conditions

Joshi, K.; Roy, S.; Biswas, R. R.; Iyer-Biswas, S.

10.1101/2023.03.07.531540 — biophysics — Posted on 2025-04-05

4406 PanSpace: Fast and Scalable Indexing for Massive Bacterial Databases

Avila Cartes, J. E.; Ciccolella, S.; Denti, L.; Dandinasivara, R.; Della Vedova, G.; Bonizzoni, P.; Schonhuth, A.

10.1101/2025.03.19.644115 — genomics — Posted on 2025-04-05

4407 Evolution under vancomycin selection drives divergent collateral sensitivity patterns in Staphylococcus aureus

Card, K. J.; Crozier, D.; Durmaz, A.; Gray, J. M.; Creary, J.; Stocks, A.; Maltas, J. A.; Bonomo, R. A.; Burke, Z. D. C.; Scott, J. G.

10.1101/2023.11.30.569373 — evolutionary biology — Posted on 2025-04-05

4408 Accelerated Discovery of Cell Migration Regulators Using Label-Free Deep Learning-Based Automated Tracking

Chu, T.; lim, y.; Sun, Y.; Wirtz, D.; wu, p.-h.

10.1101/2025.04.01.646705 — cell biology — Posted on 2025-04-05

4409 The Spc105-Kre28 complex promotes mitotic error correction by outer kinetochore recruitment of the Ipl1/Aurora B kinase

Dudziak, A.; Pleuger, R.; Schmidt, J.; Hamm, F.; Tendulkar, S.; Jaenen, K.; Vetter, I. R.; Singh, S.; Fischboeck, J.; Herzog, F.; Westermann, S.

10.1101/2024.10.01.615642 — cell biology — Posted on 2025-04-05

4410 Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides

Lee, K. K.; Lapinska, U.; Tolle, G.; Micaletto, M.; Zhang, B.; Phetsang, W.; Verderosa, A.; Invergo, B. M.; Westley, J.; Bebes, A.; Yuecel, R.; ONeill, P. A.; Farbos, A.; Jeffries, A. R.; van Houte, S.; Caboni, P.; Blaskovich, M.; Housden, B.; Tsaneva-Atanasova, K.; Pagliara, S.

10.1101/2024.04.22.590445 — microbiology — Posted on 2025-04-05

4411 Drug treatment alters performance in a neural microphysiological system of information processing

Watmuff, B.; Habibollahi, F.; Desouza, C.; Khajehnejad, M.; Loeffler, A.; Baranes, K.; Poulin, N.; Kotter, M.; Kagan, B.

10.1101/2025.01.27.635163 — neuroscience — Posted on 2025-04-05

4412 Mimicking opioid analgesia in cortical pain circuits

Oswell, C. S.; Rogers, S. A.; James, J. G.; McCall, N. M.; Hsu, A. I.; Salimando, G. J.; Mahmood, M.; Wooldridge, L. M.; Wachira, M.; Jo, A.; Sandoval Ortega, R. A.; Wojick, J. A.; Beattie, K.; Farinas, S. A.; Chehimi, S. N.; Rodrigues, A.; Ejoh, L. L.; Kimmey, B. A.; Lo, E.; Azouz, G.; Vasquez, J. J.; Banghart, M. R.; Beier, K. T.; Creasy, K. T.; Ramakrishnan, C.; Crist, R. C.; Reiner, B. C.; Deisseroth, K.; Yttri, E. A.; Corder, G.

10.1101/2024.04.26.591113 — neuroscience — Posted on 2025-04-05

4413 Whole-night gentle rocking improves sleep in poor sleepers with insomnia complaints.

Perrault, A. A.; Cross, N. E.; Dang Vu, T. T.; Schwartz, S.; Bayer, L.

10.1101/2025.03.31.646264 — neuroscience — Posted on 2025-04-05

4414 Serum metabolomics signatures after an acute bout of combined traditional or high-intensity tactical training in young males and females

Graham, Z. A.; Pathak, K. V.; Garcia-Mansfield, K.; Lavin, K.; Torres, A.; McAdam, J.; Broderick, T.; Pirrotte, P.; Bamman, M.

10.1101/2024.08.16.608249 — physiology — Posted on 2025-04-05

4415 Loss of mitochondrial pyruvate transport initiates cardiac glycogen accumulation and heart failure

Weiss, R. C.; Pyles, K. D.; Cho, K.; Brennan, M.; Fisher, J. S.; Patti, G. J.; McCommis, K. S.

10.1101/2024.06.06.597841 — physiology — Posted on 2025-04-05

4416 BEHAV3D Tumor Profiler to map heterogeneous cancer cell behavior in the tumor microenvironment

Rios-Jimenez, E.; Zomer, A.; Collot, R.; Barrera Roman, M.; Ariese, H.; L. van Ineveld, R.; Kleinnijenhuis, M.; Bessler, N.; Johnson, H.; Dawson, C.; Rios, A.; Alieva, M.

10.1101/2024.08.23.609358 — cancer biology — Posted on 2025-04-05

4417 HyDrop v2: Scalable atlas construction for training sequence-to-function models

Dickmänken, H.; Wojno, M.; Theunis, K.; Eksi, E. C.; Mahieu, L.; Christiaens, V.; Kempynck, N.; De Rop, F. V.; Roels, N.; Spanier, K. I.; Vandepoel, R.; Hulselmans, G. J.; Poovathingal, S.; Aerts, S.

10.1101/2025.04.02.646792 — bioinformatics — Posted on 2025-04-05

4418 The creation and validation of a fully animal component-free media for select adherent cell types

Mogilever, N. B.; Godin Page, M.-H.; Solola, A.; Pelling, A. E.

10.1101/2025.02.05.636679 — bioengineering — Posted on 2025-04-05

4419 Single-nucleus mRNA-sequencing reveals dynamics of lipogenic and thermogenic adipocyte populations in murine brown adipose tissue in response to cold exposure

Behrens, J.; Wang, T.; Kilian, C.; Worthmann, A.; Heeren, J.; Adlung, L.; Scheja, L.

10.1101/2025.03.28.646056 — cell biology — Posted on 2025-04-05

4420 Beyond Letters: Optimal Transport as a Model for Sub-Letter Orthographic Processing

Taylor, J. E.; Sinn, R.; Iaia, C.; Fiebach, C. J.

10.1101/2024.11.11.622929 — neuroscience — Posted on 2025-04-05

4421 Local Inhibitory Dynamics Underpin Temporal Integration and Functional Segregation between Barrels and Septa in the Mouse Barrel Cortex

Argunsah, A. O.; Stachniak, T. J.; Yang, J.-W.; Cai, L.; van der Bourg, A.; Kastli, R.; Karayannis, T.

10.1101/2024.01.23.576792 — neuroscience — Posted on 2025-04-05

4422 Accelerando and crescendo in African penguin display songs

Hersh, T. A.; Jadoul, Y.; Gamba, M.; Ravignani, A.; Favaro, L.

10.1101/2025.04.04.647185 — animal behavior and cognition — Posted on 2025-04-05

4423 MeCP2 controls dendritic morphogenesis via miR-199a-mediated Qki downregulation

Irie, K.; Nakashima, H.; Yamaguchi, M.; Osakada, F.; Ozaki, N.; Nakashima, K.; Tsujimura, K.

10.1101/2025.04.04.642981 — neuroscience — Posted on 2025-04-05

4424 Pyruvate kinase deficiency links metabolic perturbations to neurodegeneration and axonal protection

Waller, T. J.; Collins, C. A.; Dus, M.

10.1101/2025.04.04.647282 — neuroscience — Posted on 2025-04-05

4425 Individual differences in sequential decision-making

Abbaszadeh, M.; Ozanick, E.; Magen, N.; Darrow, D. P.; Yan, X.; Herman, A.; Ebitz, B.

10.1101/2025.04.04.647306 — neuroscience — Posted on 2025-04-05

4426 Glucocorticoid receptors mediate reprogramming of astrocytes in depression.

Dalbeyler, S.; Herud, A.; Zglinicki, B.; Ziuzia, P.; Piechota, M.; Hoinkis, D.; Bergauer, L.; Pando, C. M.; Soltys, Z.; Hanus, P.; Groves, P.; Dixon, L.; Ganglberger, F.; Del Prete, D.; Dubovyk, V.; Assfalg, M.; Violet, C.; Lawless, N.; Kielbasa, S. M.; Sigrist, H.; Pryce, C.; Turecki, G.; Schmidt, M. V.; Benes, V.; Kuner, T.; Korostynski, M.; Hengerer, B.; Slezak, M.

10.1101/2025.04.04.646549 — neuroscience — Posted on 2025-04-05

4427 Parametric Modulation of a Shared Midbrain Circuit Drives Distinct Vocal Modes in a Singing Mouse

Zheng, X. M.; Harpole, C. E.; Davis, M. B.; Banerjee, A.

10.1101/2025.04.04.647309 — neuroscience — Posted on 2025-04-05

4428 Functional interrogation of neuronal connections by chemoptogenetic presynaptic ablation

Sharma, H.; Robea, M. A.; McGrory, N. H.; Bazan, D. C.; Burton, E. A.; Burgess, H. A.

10.1101/2025.04.04.647277 — neuroscience — Posted on 2025-04-05

4429 Incorporating special interests to investigate the language system in autism: A feasibility pilot fMRI study

Olson, H. A.; Johnson, K. T.; Nishith, S.; Gabrieli, J. D. E.; D'Mello, A. M.

10.1101/2025.04.04.647117 — neuroscience — Posted on 2025-04-05

4430 A TranSNP in the DDIT4 mRNA can impact its translation efficiency and modulate p53-dependent responses in cancer cells

Hamadou, M. H.; Alunno, L.; Venturelli, T.; Valentini, S.; Dalfovo, D.; Lorenzini, F.; Mattivi, A.; Vigorito, V.; Grupelli, G. P.; Matte', A.; Gatto, P.; Pancher, M.; Valentini, C.; De Sanctis, V.; Bertorelli, R.; Marcel, V.; Cusanelli, E.; Freddi, S.; Bertalot, G.; Zaccara, S.; Mione, M.; Fava, L. L.; Romanel, A.; Inga, A.

10.1101/2025.04.02.646512 — molecular biology — Posted on 2025-04-04

4431 Comparison of spatio-temporal dynamics and composition in size-fractionated and unfractionated Northwestern Atlantic microbial communities

Haider, D.; Tolman, J.; Beiko, R. G.; Laroche, J.

10.1101/2025.04.03.647080 — molecular biology — Posted on 2025-04-04

4432 Assay for Rapid Quantification of Capped and Tailed Intact mRNA

Gao, R. Y.; Hu, T.; Taylor, A. W.; Lacey, R.; Thomas, K. N.; McCormick, C.; Miller, D. F.; Rowlen, K. L.; Dawson, E. D.

10.1101/2025.04.02.646833 — molecular biology — Posted on 2025-04-04

4433 Strain-specific differences in toxT expression and virulence gene activation in Vibrio cholerae

Joo, J.; Lee, D.; Choi, S.; Kim, H.; Kim, D. W.; Kim, E. J.

10.1101/2025.04.04.647171 — microbiology — Posted on 2025-04-04

4434 Validation of diverse and previously untraceable Sendai virus copyback viral genomes by Direct RNA Sequencing

Pye, S.; Achouri, E.; Yang, Y.; Musa, A.; Lopez, C. B.

10.1101/2025.04.04.647164 — microbiology — Posted on 2025-04-04

4435 Enhancing Tissue-Specific Antiviral Immunity to Disrupt Arbovirus Transmission by Mosquitoes

Dong, S.; Ciomperlik-Patton, J.; Zhao, Y.; Dong, Y.; Myles, K. M.; Dimopoulos, G.

10.1101/2025.04.04.647234 — microbiology — Posted on 2025-04-04

4436 Navigating Neurological Re-emergence in Feline Infectious Peritonitis: Challenges and Insights from GS-441524 and Remdesivir Treatment

de Witt Curtius, C. C.; Rodary, M.; Hofmann-Lehmann, R.; Spiri, A. M.; Meli, M. L.; Crespo Bouzon, A.; Wenk, J.; Cerchiaro, I.; Pineroli, B.; Pot, S. A.; Beckmann, K.; Chan, T.; Wieser, M.; Unterer, S.; Felten, S.; Meunier, S. M.

10.1101/2025.04.04.646959 — microbiology — Posted on 2025-04-04

4437 Suppressing selection for antibiotic resistance in the environment: A transparent, ecology-based approach to predicted no-effect concentrations

Kneis, D.; de la Cruz Barron, M.; Konyali, D.; Westphal, V.; Schröder, P.; Westphal-Settele, K.; Schönfeld, J.; Jungmann, D.; Berendonk, T. U.; Klümper, U.

10.1101/2025.04.04.647007 — microbiology — Posted on 2025-04-04

4438 The producer cell type of HSV-1 alters the proteomic contents and infectious capacity of virions

Dunn, G. P.; Domanico, L. F.; Taylor, M. P.

10.1101/2025.04.04.647173 — microbiology — Posted on 2025-04-04

4439 Antimicrobial and Antioxidant Activity of Ethanolic Extracts of Charred and Uncharred Skins of Four-Toed Hedgehog, Atelerix albiventris (Erinaceidae) used in Traditional Management of Boils in Ghana

Ameade, E. P. K.; Aidoo, A. M. Y.; Amankwah, F. K. D.; Adom, E.

10.1101/2025.04.02.646865 — microbiology — Posted on 2025-04-04

4440 A transfer RNA methyltransferase with an unusual domain composition catalyzes 2'-O-methylation at position 6 in tRNA.

Matsuda, T.; Yamagami, R.; Ihara, A.; Suzuki, T.; Hirata, A.; Hori, H.

10.1101/2025.04.03.647152 — biochemistry — Posted on 2025-04-04

4441 Optimized pipeline for generating highly potent neutralizing Affitins: application to SARS-CoV-2 spike protein

Maurice, T.; Laporte, M.; Barquilla, N.; Fortun, A.; Echasserieau, K.; Guivel-Benhassine, F.; Barbosa, A.; Cossard, P.; Planchais, C.; Anna, F.; Charneau, P.; Mouquet, H.; Roque, C.; Schwartz, O.; Mouratou, B.; Davodeau, F.; Bernardeau, K.; Monel, B.; Pecorari, F.

10.1101/2025.04.03.646589 — biochemistry — Posted on 2025-04-04

4442 Biochemical characterization of cyanobacterial HtpG from Synechococcus elongatus PCC 7942

Jiang, L.; Boyenle, I.; Delaeter, N.; Liu, Y.

10.1101/2025.04.03.647111 — biochemistry — Posted on 2025-04-04

4443 Molecular basis for multidrug efflux by an anaerobic RND transporter

10.1101/2025.04.04.646765 — biochemistry — Posted on 2025-04-04

4444 Complex carbohydrates catabolism capacity of bladder microbiota inhabiting healthy and overactive female bladders

Gourdine, J.-P.; Pacentine, I. V.; Barstad, A.; Dahl, E. M.; Gregory, W. T.; Wolfe, A. J.; Sysoeva, T. A.; Karstens, L.

10.1101/2025.04.02.646827 — biochemistry — Posted on 2025-04-04

4445 Adaptively integrated sequencing and assembly of near-complete genomes

Gamaarachchi, H.; Stevanovski, I.; Hammond, J. M.; Reis, A. L. M.; Rapadas, M.; Jayasooriya, K.; Russell, T.; Yeow, D.; Hort, Y.; Mallett, A. J.; Stackpoole, E.; Roman, L.; Silver, L. W.; Hogg, C. J.; Streeting, L.; Bogdanovic, O.; Rodrigues, R.; Nascimento, L.; Cardoso, A. L.; Georges, A.; Cheng, H.; Patel, H. R.; Kumar, K. R.; Mallawaarachchi, A. C.; Deveson, I. W.

10.1101/2025.03.31.646505 — genomics — Posted on 2025-04-04

4446 Minos-mediated transgenesis in the pantry moth Plodia interpunctella

Shodja, D. N.; Martin, A.

10.1101/2025.04.03.647036 — genetics — Posted on 2025-04-04

4447 Structural Basis for Promoter Recognition and Transcription Factor Binding and Release in Human Mitochondria

Herbine, K.; Nayak, A. R.; Zamudio-Ochoa, A.; Temiakov, D.

10.1101/2025.04.03.647028 — molecular biology — Posted on 2025-04-04

4448 Crosstalk Among Disrupted Blood-Brain Barrier, Neuroinflammation, and Coagulopathy in AC70 hACE2 Tg Mice with Prolonged Neurological Manifestations Induced by the Omicron BA.1 Variant of SARS-CoV-2

Drelich, A. K.; Saenkham-Huntsinger, P.; Wang, Y.-H. E.; Xie, X.; Judy, B. M.; Ksiazek, T. G.; Peng, B.-H.; Tseng, C.-T. K.

10.1101/2025.04.03.646981 — microbiology — Posted on 2025-04-04

4449 Longitudinal study of the udder microbiome of Norwegian red dairy cows using metataxonomic and shotgun metagenomic approaches: Insights into pathogen-driven microbial adaptation and succession

Da Silva Duarte, V.; Franklin, F.; Krysmann, A. M.; Porcellato, D.

10.1101/2025.04.04.647183 — microbiology — Posted on 2025-04-04

4450 In Vivo Dual RNA-Seq uncovers key toxin-like effectors of epithelial barrier disruption and tissue colonization by an extracellular bacterial pathogen

Giraud-Gatineau, A.; Haustant, G.; Monot, M.; Picardeau, M.; BENAROUDJ, N.

10.1101/2025.04.04.647190 — microbiology — Posted on 2025-04-04

4451 Investigating microbiota differences across chronic pancreatitis, influenced by lifestyle and genetic determinants

Ahmed, A. Y. M.; Rajai, A.; Fullwood, C.; Rivett, D. W.; McLaughlin, J.; van der Gast, C.; Marsh, R.

10.1101/2025.04.04.647187 — microbiology — Posted on 2025-04-04

4452 Artificial soil systems: A tool for investigating microbial life strategy effects on substrate mineralization

Fujiwara, K.; Makino, T.; HAMAMOTO, T.

10.1101/2025.04.04.647204 — microbiology — Posted on 2025-04-04

4453 Genetic modification of intractable staphylococcal clones by heat-shock facilitated phage transduction

Schulze, L.; Moessner, J.; Krauss, S.; Harbig, T. A.; Nieselt, K.; Krismer, B.; Peschel, A.

10.1101/2025.04.04.647181 — microbiology — Posted on 2025-04-04

4454 GH25 lysozyme mediates tripartite interkingdom interactions and microbial competition on the plant leaf surface

Sorger, Z.; Sengupta, P.; Beier-Heuchert, K.; Bautor, J.; Parker, J. E.; Kemen, E.; Doehlemann, G.

10.1101/2025.04.04.647216 — microbiology — Posted on 2025-04-04

4455 Ebola's Hidden Target: Virus Transmission to and Accumulation within Skin

Richards, P. T.; Fleck, A.; Patel, R.; Fakhimi, M.; Bohan, D.; Geohegan-Barek, K.; Stolte, A. E.; Messingham, C. O.; Connell, S.; Crowe, T.; Gourronc, F. A.; Carrion, R.; Griffiths, A.; Meyerholz, D. K.; Klingelhutz, A. J.; Davey, R. A.; Messingham, K. N.; Maury, W.

10.1101/2025.04.04.647113 — microbiology — Posted on 2025-04-04

4456 Boosting Bug Farms: A Meta-Analysis on Probiotic Effects in Insect Rearing

Haebermann, J.; Antunes, B.; Haase, H.; Rolff, J.; Keil, C.; Rafaluk, C.

10.1101/2025.04.04.647199 — microbiology — Posted on 2025-04-04

4457 Viral and bacterial traits associated with the success of the yellow pencil coral, Madracis mirabilis, in Curacaos coral reefs

Silveira, C.; Wallace, B. A.; Varona, N. S.; Stiffler, A. K.; Vermeij, M. J. A.

10.1101/2025.04.04.647251 — microbiology — Posted on 2025-04-04

4458 Superinfection with intact HIV-1 results in conditional replication of defective proviruses and nonsuppressible viremia in people living with HIV-1

Hariharan, V.; White, J. A.; Dragoni, F.; Fray, E. J.; Pathoulas, N.; Moskovljevic, M.; Zhang, H.; Singhal, A.; Lai, J.; Beg, S. A.; Scully, E. P.; Gilliams, E. A.; Block, D. S.; Keruly, J.; Moore, R. D.; Siliciano, J. D.; Simonetti, F. R.; Siliciano, R. F.

10.1101/2025.04.04.647291 — microbiology — Posted on 2025-04-04

4459 Detection of Infectious Murine Norovirus on Fresh Produce through a Novel CRISPR/Cas13-based Sensitive Assay

Garcia, S.; Ossio, A.; Heredia, N.; Merino-Mascorro, A.; Leon, J. S.

10.1101/2025.04.04.647263 — microbiology — Posted on 2025-04-04

4460 Infant CD4 T-cell response to SARS-CoV-2 mRNA vaccination is restricted in cytokine production and modified by vaccine manufacturer

Peters, M. Q.; Young, A. L.; Stolarczuk, J. E.; Glad, M.; Layton, E.; Logue, J. K.; Minkah, N. K.; Chu, H. Y.; Englund, J. A.; Sather, N.; Seshadri, C.; Kachikis, A.; Harrington, W. E.

10.1101/2025.04.02.646864 — immunology — Posted on 2025-04-04

4461 JACUZI-SD: An automated, high-throughput, minimally stressful approach to sleep depriving larval zebrafish.

Elias, L. J.; Khoo, H.; Kroll, F.; Zhang, C.; Hur, S. C.; Rihel, J.; Blackshaw, S.

10.1101/2025.04.03.647099 — neuroscience — Posted on 2025-04-04

4462 Many weak and few strong links: The importance of interaction strength distributions for stabilising patterns in competition networks

Koch, F.; Neutel, A.-M.; Barnes, D. K.; Allhoff, K. T.

10.1101/2024.01.25.577181 — ecology — Posted on 2025-04-04

4463 Enhanced 5mC-Methylation-Site Recognition in DNA Sequences using Token Classification and a Domain-specific Loss Function

Zeng, W.; Huson, D.

10.1101/2023.06.01.543218 — bioinformatics — Posted on 2025-04-04

4464 Expression of human CEACAMs promotes inflammation and organ damage during systemic Candida albicans infection in mice

Klaile, E.; Müller, M. M.; Sonnberger, J.; Bothe, A.-K.; Brehme, S.; Ehrenpfordt, J.; Klassert, T.; Kuhn, S.; Dietert, K.; Kershaw, O.; Praetorius, J.-P.; Figge, M. T.; Bauer, T.; Gebhardt, A.; Mall, G.; Jacobsen, I. D.; Slevogt, H.

10.1101/2025.03.29.646107 — immunology — Posted on 2025-04-04

4465 Compensatory evolution following deleterious episodes of GC-biased gene conversion in rodents

Riffis, M.; Saclier, N.; Galtier, N.

10.1101/2025.01.08.631863 — genomics — Posted on 2025-04-04

4466 Learning and cognition in highspeed decision making

Krause, M.; Schulze, W.; Schuster, S.

10.1101/2024.06.24.600552 — animal behavior and cognition — Posted on 2025-04-04

4467 BCAS2 promotes primitive hematopoiesis by sequestering β-catenin within the nucleus

Ning, G.; Lin, Y.; Ma, H.; Zhang, J.; Yang, L.; Liu, Z.; Li, L.; He, X.; Wang, Q.

10.1101/2024.07.17.603892 — developmental biology — Posted on 2025-04-04

4468 OPUS-TOMO: Deep Learning Framework for Structural Heterogeneity Analysis in Cryo-electron Tomography

Luo, Z.; Chen, X.; Wang, Q.; Ma, J.

10.1101/2024.06.30.601442 — molecular biology — Posted on 2025-04-04

4469 Autonomic responses to proprioceptive and visual errors during single-trial reach adaptation

Nogami, M.; Hagura, N.; Yokoi, A.

10.1101/2025.03.31.646172 — neuroscience — Posted on 2025-04-04

4470 A proteogenomic tool uncovers protein markers for human microglial states

Haage, V.; Bautista, A. R.; Tuddenham, J. F.; Marshe, V.; Chiu, R.; Liu, Y.; Lama, T.; Kelly, S. S.; Parghi, N. A.; Park, J.; Buonfiglioli, A.; Furnari, J. L.; Haq, I.; Pearse, R.; Patel, R.; Terzioglu, G.; Touil, H.; Zeng, L.; Noble, J.; Sarkis, R. A.; Shneider, N. A.; de Witte, L.; Schneider, J. A.; Teich, A.; Young-Pearse, T. L.; Riley, C.; Bennett, D. A.; Canoll, P.; Bruce, J. N.; Howden, A. J.; Lloyd, A. F.; De Strooper, B. F.; Sher, F.; Sproul, A. A.; Olah, M.; Taga, M.; Zhang, Y.; Caisheng, L.; Fujita, M.; Petyuk, V. A.; De Jager, P. A.

10.1101/2025.03.31.646212 — neuroscience — Posted on 2025-04-04

4471 Differential Adaptation and Remodeling of the Tumor Microenvironment in Breast Cancer Cells During the Stages of Brain Metastasis

Wu, X.; Zhang, Y.; Huang, Z.; Li, R.

10.1101/2023.07.13.548875 — cancer biology — Posted on 2025-04-04

4472 LncMamba: A Deep Learning Model for lncRNA Localization Prediction Based on the Mamba Model

Huang, B.; Luo, Y.; Zhuang, Y.; He, S.; Yuan, C.

10.1101/2025.03.29.646080 — bioinformatics — Posted on 2025-04-04

4473 genomicBERT: A Light-weight Foundation Model for Genome Analysis using Unigram Tokenization and Specialized DNA Vocabulary

Chen, T.; Vahab, N.; Cummins, E.; Tyagi, N.; Peleg, A. Y.; Tyagi, S.

10.1101/2023.05.31.542682 — bioinformatics — Posted on 2025-04-04

4474 Evidence of Gait Impairment After mTBI in an Adolescent Pig Model

Vizzeswarapu, N.; Kanat, S.; Bush, T. R.; Pelled, G.

10.1101/2025.03.31.646330 — bioengineering — Posted on 2025-04-04

4475 Spatial transcriptomics AI agent charts hPSC-pancreas maturation in vivo

Lin, Z.; Wang, W.; Marin-Llobet, A.; Li, Q.; Pollock, S. D.; Sui, X.; Aljovic, A.; Lee, J.; Baek, J.; Liang, N.; Zhang, X.; Wang, C. K.; Huang, J.; Liu, M.; Gao, Z.; Sheng, H.; Du, J.; Lee, S. J.; Wang, B.; He, Y.; Ding, J.; Wang, X.; Alvarez, J. R.; Liu, J.

10.1101/2025.04.01.646731 — genomics — Posted on 2025-04-04

4476 Unlocking prophage potential: In silico and experimental analysis of a novel Mycobacterium fortuitum LysinB containing a peptidoglycan-binding domain

Das, R.; Nadar, K.; Arora, R.; Bajpai, U.

10.1101/2024.02.15.580446 — molecular biology — Posted on 2025-04-04

4477 A microenvironment-driven, HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes

Srivastava, N.; Vomund, A.; Peterson, O.; Yang, Y.; Turicek, D. P.; Zulkifli, A.; Abousaway, O.; Li, T.; Kain, L.; Stone, P.; Ansar, A.; Clement, C.; Sharma, S.; Zhang, B.; Liu, C.; Joglekar, A.; Hu, H.; Hsieh, C.-S.; Campisi, L.; Santambrogio, L.; Teyton, L.; Unanue, E. R.; Arbelaez, A. M.; Lichti, C.; Wan, X.

10.1101/2024.11.07.622538 — immunology — Posted on 2025-04-04

4478 Coming up short: generative network models fail to accurately capture long-range connectivity

Oldham, S.; Fornito, A.; Ball, G.

10.1101/2024.11.18.624192 — neuroscience — Posted on 2025-04-04

4479 A slow and clathrin-dependent mode of compensatory endocytosis in hippocampal boutons at near-physiological temperature

Kahms, M.; Pandey, S.; Klingauf, J.

10.1101/2025.03.31.646354 — neuroscience — Posted on 2025-04-04

4480 Optical recordings of synaptic vesicle fusion reveal diffusional dispersion

Lehrich, J.; Glyvuk, N.; Duan, J.; Krishnan, S.; Tsytsyura, Y.; Keller, U.; Sunil, L. P.; Nosov, G.; Hueve, J.; Selenschik, P.; Reissner, C.; Missler, M.; Kahms, M.; Klingauf, J.

10.1101/2025.03.31.646326 — neuroscience — Posted on 2025-04-04

4481 Goal-directed visual information processing with GABAergic inhibition in parietal cortex

Wang, Z.; Wiborg, S.; Wittman, A.; Beck, N.; Becker, M.; Frank, S. M.

10.1101/2025.03.26.645504 — neuroscience — Posted on 2025-04-04

4482 Circadian rhythms and the light-dark cycle interact to regulate amyloid plaque accumulation and tau phosphorylation in 5xFAD mice

King, M. W.; Jacob, S.; Sharma, A.; Lawrence, J. H.; Weaver, D. R.; Musiek, E. S.

10.1101/2025.03.31.645805 — neuroscience — Posted on 2025-04-04

4483 A heart releasing neuropeptide that synchronizes brain-heart regulation during courtship behavior

Li, H.; Cheng, S.; Niu, Y.; Diao, T.; Zhang, Q.; Zhang, W.

10.1101/2025.03.31.646145 — neuroscience — Posted on 2025-04-04

4484 Single cell spatial transcriptomics identifies coordinated cellular programs associated with good prognosis in microsatellite stable colorectal cancer

Karlsen, V. T.; Majid, U.; Lindholm, H. T.; Umu, S. U.; Vander-Elst, K. R.; Beitnes, A.-C. R.; Merok, M. A.; Hagen, K. T.; Nilsen, H. R.; Yaqub, S.; Baekkevold, E. S.; Domanska, D.; Jahnsen, F. L.

10.1101/2025.03.31.646286 — cancer biology — Posted on 2025-04-04

4485 Mapping the spatial architecture of glioblastoma from core to edge delineates niche-specific tumor cell states and intercellular interactions

Khan, S. M.; Wang, A. Z.; Desai, R. R.; McCornack, C. R.; Sun, R.; Dahiya, S. M.; Foltz-Stringfellow, J.; Sherpa, N. D.; Leavitt, L.; West, T. R.; Wang, A. F.; Krbanjevic, A.; Choi, B. D.; Leuthardt, E. C.; Patel, B.; Charest, A.; Kim, A. H.; Dunn, G. P.; Petti, A. A.

10.1101/2025.04.04.647096 — cancer biology — Posted on 2025-04-04

4486 Generalizable Neural Models of Emotional Engagement and Disengagement

Nanni Zepeda, M.; Evans, T.; Jagger-Rickels, A.; Raz, G.; Hendler, T.; Fan, Y.; Grimm, S.; Walter, M.; Esterman, M.; Zuberer, A.

10.1101/2024.02.15.579332 — neuroscience — Posted on 2025-04-04

4487 Endocrine modulation of cortical and retinal blood flow across the menstrual cycle

Wright, M. E.; Crofts, C.; Davies, S.; Chandler, H. L.; Driver, I. D.; Germuska, M.; Giarratano, Y.; Rashid, D.; Bernabeu, M. O.; Terry, L.; Steventon, J. J.; Murphy, K.

10.1101/2024.12.19.629235 — neuroscience — Posted on 2025-04-04

4488 Agent-Based Simulation of Cortical Microtubule Band Movement in the Arabidopsis Zygote

Nonoyama, T.; Kang, Z.; Matsumoto, H.; Nakagawa, S.; Ueda, M.; Tsugawa, S.

10.1101/2024.10.17.618799 — plant biology — Posted on 2025-04-04

4489 THE UNCHARTED ROLE OF ERAP2 IN AGING: A BIOINFORMATICS PERSPECTIVE

Akbar, A.

10.1101/2025.03.30.646199 — immunology — Posted on 2025-04-04

4490 Effects of aperiodic neural activity on sleep-based emotional memory consolidation across the lifespan

Cross, Z. R.; Santamaria, A.; Coussens, S. W.; Kohler, M. J.

10.1101/2025.03.30.646183 — neuroscience — Posted on 2025-04-04

4491 UnitRefine: A Community Toolbox for Automated Spike Sorting Curation

Jain, A.; Greene, R.; Halcrow, C.; Swann, J.; Kleinjohann, A.; Spurio, F.; Graff, S.; Kampa, B.; Gall, J.; Gruen, S.; Buccino, A. P.; Hennig, M. H.; Musall, S.

10.1101/2025.03.30.645770 — neuroscience — Posted on 2025-04-04

4492 Analysis of β rhythm induction in acute brain slices using field potential imaging with ultra-high-density CMOS-based microelectrode array.

Takakhashi, H.; Matsuda, N.; Suzuki, I.

10.1101/2025.03.30.646248 — neuroscience — Posted on 2025-04-04

4493 Development of a Microelectrode Array System for Simultaneous Measurement of Field Potential and Glutamate Release in Brain Slices

Hasegawa, A.; Matsuda, N.; Suzuki, I.

10.1101/2025.03.30.646242 — neuroscience — Posted on 2025-04-04

4494 Plasticity induction in the ventromedial prefrontal cortex during REM sleep improves fear extinction memory consolidation

Markovic, V.; Rizzo, G.; Yavari, F.; Vicario, C.; Nitsche, M.

10.1101/2025.03.31.646182 — neuroscience — Posted on 2025-04-04

4495 Presence of an unfamiliar peer reverses escalated cocaine intake in male rats: involvement of the subthalamic nucleus

Vielle, C.; Vignal, L.; Tiran-Cappello, A.; Meffre, J.; Maurice, N.; Degoulet, M.; Brocard, C.; Pelletier, F.; Pelloux, Y.; Baunez, C.

10.1101/2023.02.07.527550 — neuroscience — Posted on 2025-04-04

4496 Hypoxia-induced extracellular matrix changes are conserved in cancer and directly impact radiotherapy benefit

Guerrero Quiles, C.; Gonzalez Abalos, J.; Foussat, A. S.; Olympitis, A.; Lodhi, T.; Smith, V.; Reardon, M.; Shabbir, R.; Lunj, S.; Reeves, K.; Baker, A.; Eyres, M.; Marshall, G.; Smith, T.; Hoskin, P.; James, N.; Hall, E.; Huddart, R.; Porta, N.; Biolatti, V.; Humphries, J. D.; Humphries, M.; Choudhury, A.; West, C.

10.1101/2025.04.04.647191 — cancer biology — Posted on 2025-04-04

4497 Lysophosphatidic acid controls autotaxin binding to 1-integrin: impact on disease progression in murine collagen-induced arthritis.

Emery, M.; Cuero, C. N.; Bouazza, L.; Internicola, C.; Duboeuf, F.; Cerecero-Aguirre, P.; McCarthy, A. A.; Machuca-Gayet, I.; Leblanc, R.; Peyruchaud, O.

10.1101/2025.04.04.646839 — cell biology — Posted on 2025-04-04

4498 Observational social learning of "know-how" and "know-what" in wild orangutans: evidence from nest-building skill acquisition

Permana, A.; Permana, J. J.; Nellissen, L.; Prayogi, E. S.; Prasetyo, D.; Wich, S. A.; van Schaik, C. P.; Schuppli, C.

10.1101/2025.04.04.646832 — animal behavior and cognition — Posted on 2025-04-04

4499 BRCA1 is a molecular correlate of cell proliferation in human brain development and in Group 3 and 4 medulloblastoma

Cheong, I.; Sun, X.; Lau, L.; Kishore, N.; Senff-Ribeiro, A.; Diaz-Navarro, A.; Hajari, H.; Mak, E.; Ahluwalia, R.; Bianchini, L.; Singh Sandhu, J.; Taylor, M. D.; Kutscher, L.; Stein, L. D.; Pai, S.

10.1101/2025.04.03.646803 — genomics — Posted on 2025-04-04

4500 Brain Network Segregation is Associated with Drug Use Severity in Individuals with Opioid Use Disorder

Hager, N. M.; Wang, X.; Ramos-Ralon, A. P.; Childress, A. R.; Langleben, D. D.; Wiers, C. E.; Shi, Z.

10.1101/2025.04.02.646889 — neuroscience — Posted on 2025-04-04

4501 BABA: Naturalistic fMRI and MEG recordings during viewing of a reality TV show

Li, J.; Wang, Q.; Wang, Y.; Wang, C.; Ma, Z.; Xu, R.; Feng, S.; Jiang, X.; Meng, Z.

10.1101/2025.04.03.646958 — neuroscience — Posted on 2025-04-04

4502 Mice lacking the endocannabinoid-synthesizing enzyme NAPE-PLD exhibit sex-dependent dysregulations in responsiveness to oxycodone and a natural reward

Woodward, T. J.; Sizemore, E. F.; Balaji, A.; Port, A. L.; Hainline, J. J.; Kazi, H.; Luquet, S.; Mackie, K.; Hohmann, A. G.

10.1101/2025.04.03.646908 — neuroscience — Posted on 2025-04-04

4503 Prominent white matter related abnormalities associated with diverse molecular alterations in a mouse model of Col4a1 cerebral small vessel disease.

Brezzo, G.; Pokhilko, A.; Moss, J.; Koudelka, J.; Jansen, M. A.; Lennen, R.; Thompson, G.; Konstantinidou, S. M.; Yau, J.; Boland, E.; Williams, A.; Allan, S. M.; Granata, A.; Sinha, S.; Wang, T.; Markus, H. S.; Fisher, R.; Cader, M. Z.; Van Agtmael, T.; Horsburgh, K.

10.1101/2025.04.04.647207 — neuroscience — Posted on 2025-04-04

4504 Audiovisual processing is selectively impaired in the primary visual cortex but not in the posterior parietal cortex of a mouse model of Fragile X syndrome

Montelisciani, L.; Bosman, C. A.; Olcese, U.

10.1101/2025.04.04.647162 — neuroscience — Posted on 2025-04-04

4505 Attentional engagement with target and distractor streams predicts speech comprehension in multitalker environments

Barchet, A. V.; Bruera, A.; Wend, J.; Rimmele, J. M.; Obleser, J.; Hartwigsen, G.

10.1101/2025.04.04.647157 — neuroscience — Posted on 2025-04-04

4506 Dual-site beta transcranial alternating current stimulation during a bimanual coordination task modulates functional connectivity between motor areas

Gann, M. A.; Paparella, I. A.; Zich, C.; Grigoras, I.; Huertas-Penen, S.; Rieger, S. W.; Thielscher, A.; Sharott, A.; Stagg, C. J.; Schwab, B. C.

10.1101/2025.04.04.647211 — neuroscience — Posted on 2025-04-04

4507 Primulagenin A is a potent inverse agonist of the nuclear receptor RAR-related orphan receptor gamma (RORγ)

10.1101/2025.04.01.646598 — pharmacology and toxicology — Posted on 2025-04-04

4508 Lymphatic Malformations with Activating KRAS Mutations Impair Lymphatic Valve Development Through Matrix Metalloproteinases

Mastrogiacomo, D. M.; Price, A.; Fu, Y.; Banerjee, R.; Knauer, L. A.; Li, K.; Yang, Y.; Davis, G. E.; Dellinger, M.; Scallan, J. P.

10.1101/2025.04.02.646922 — pathology — Posted on 2025-04-04

4509 Hematobiochemical Alterations and Pathological Lesions Induced by Fasciolosis in Slaughtered Cattle at Gondar ELFORA Abattoir, Ethiopia

Temesgen, A. B.; Mitiku, T.; Birhan, M.; Kebede, M. C.; Yesuf, M.; Mekonnen, M. Y.; Alemayehu, M. M.; Malede, B. A.; Geda, A. M.; Tumebo, A. W.; Shiferaw, K. A.; Wassie, Z. G.; Berie, G. K.; Mengistu, B. A.; Feleke, M. G.; Edenshaw, F.; Yitie, M. T.; Kasse, G. E.; Tsehay, E. M.; Shiferaw, S. A.

10.1101/2024.08.10.607441 — pathology — Posted on 2025-04-04

4510 A guide for Single Particle Tracking: from sample preparation and image acquisition to the analysis of individual trajectories

Kobayashi, A.; Park, J.; Mine-Hattab, J.; Fernandez, F. G.

10.1101/2025.04.03.647105 — biophysics — Posted on 2025-04-04

4511 The response of the relationship between carbon components and soil aggregates in vegetable fields to continuous input of different carbon sources

Peng, Y. Y.; Xilatu, D.; Huang, J. L.; Peng, Y. Q.; PENG, Y.; Li, S. X.

10.1101/2025.04.02.646932 — biophysics — Posted on 2025-04-04

4512 FedNolowe: A Normalized Loss-Based Weighted Aggregation Strategy for Robust Federated Learning in Heterogeneous Environments

Le, D.-D.; Huynh, T.-N.; Tran, A.-K.; Dao, M.-S.; Bao, P. T.

10.1101/2025.03.30.646222 — bioinformatics — Posted on 2025-04-04

4513 Development and Clinical Evaluation of a Multiplexed Health Surveillance Panel Using Ultra High-Throughput PRM-MS in an Inflammatory Bowel Disease Cohort.

Fu, Q.; Remes, P. M.; Lee, J.; Jacob, C.; Li, D.; Vegensna, M.; Raedschelders, K.; Haghani, A.; Mengesha, E.; Debbas, P.; Hoedt, E.; Joung, S.; Cheng, S.; Peterman, S.; Fert-Bober, J.; Melmed, G. Y.; McGovern, D. P. B.; Murray, C. I.; Van Eyk, J. E.

10.1101/2025.04.02.646850 — biochemistry — Posted on 2025-04-04

4514 Causal affordances shape Hornbills' problem-solving strategies

Garcia-Pelegrin, E.

10.1101/2025.04.03.646957 — animal behavior and cognition — Posted on 2025-04-04

4515 Population structure and domestication history of the Javan banteng (Bos javanicus javanicus)

Wang, X.; Aninta, S. G.; Garcia-Erill, G.; Li, Z.; Khan, A.; Liu, X.; Bertola, L. D.; Dharmayanthi, A. B.; Yulianto, ; Yonathan, ; Rossi, C.; Cauble-Sims, R.; Rosen, B. D.; Hagen, D. E.; Heaton, M. P.; Smith, T. P. L.; Lenstra, J. A.; Martins, N. F. G.; Sinding, M.-H. S.; Agil, M.; Purwantara, B.; Hvilsom, C.; Semiadi, G.; Heller, R.

10.1101/2025.04.01.646613 — evolutionary biology — Posted on 2025-04-04

4516 DNA origami vaccine (DoriVac) nanoparticles improve both humoral and cellular immune responses to infectious diseases

Zeng, Y.; Young, O.; Xiong, Q.; Si, L.; Ku, M. W.; Bernier, S.; Dembele, H.; Isinelli, G.; Gilboa, T.; Swank, Z.; Seok, S. H.; Rajwar, A.; Jiang, A.; Zhai, Y.; Williams, L.; Hellman, C.; Wintersinger, C.; Graveline, A.; Vernet, A.; Sanchez, M.; Bardales, S.; Tomara, G.; Ryu, J. H.; Kwon, I. C.; Goyal, G.; Ingber, D.; Shih, W.

10.1101/2023.12.29.573647 — immunology — Posted on 2025-04-04

4517 Embodied decisions as active inference

Priorelli, M.; Stoianov, I. P.; Pezzulo, G.

10.1101/2024.05.28.596181 — neuroscience — Posted on 2025-04-04

4518 Prevalence of bovine fasciolosis and identify the risk factors in and around Bahir Dar, Ethiopia

Mesfin, T.; Solomon, T.; Temesgen, A. B.

10.1101/2024.08.07.606800 — pathology — Posted on 2025-04-04

4519 An updated compendium of Caenorhabditis elegans RNA-binding proteins and their regulation

Peng, F.; Murray, J. I.

10.1101/2025.03.31.646443 — genetics — Posted on 2025-04-04

4520 Regional species coexistence despite local priority effects: the overlooked role of dispersal-community feedback

Nell, L. A.; Klausmeier, C. A.; Fukami, T.

10.1101/2025.03.31.646410 — ecology — Posted on 2025-04-04

4521 Land-use intensity effects on the biodiversity-ecosystem functioning relationship in semi-natural grasslands at management-relevant spatial scales

Meyer, S. N.; Muro, J.; Woellauer, S.; Schwarz, L.-M.; Maenner, F. A.; Dubovyk, O.; Linstaedter, A.

10.1101/2025.03.31.646360 — ecology — Posted on 2025-04-04

4522 How drought and ploidy level shape gene expression and DNA methylation in Phragmites australis

Kuprina, K.; Haldan, K.; Saenko, S.; Gulam, M. S.; Kreyling, J.; Schnittler, M.; Bog, M.

10.1101/2025.03.31.646440 — ecology — Posted on 2025-04-04

4523 Topoisomerase IIα orchestrates secretion of IL-6 and IL-8 with human papillomavirus replication

Liu, Y.; Han, Z.; Kaminski, P.; Tao, C.; Li, X.; Liu, M.; Li, Y.; Jia, Y.; Xu, J.; Hong, S.

10.1101/2025.04.03.647014 — microbiology — Posted on 2025-04-04

4524 Rheinheimera palamurensis sp. a novel bacterium isolated from drinking water resources

Paul, T. R.; Shiva Shanker, A.; Kumar, D. K. S.; Srinivasulu, D.; Vootla, P. K.; Pindi, P. K.

10.1101/2025.04.03.647078 — microbiology — Posted on 2025-04-04

4525 Membrane curvature regulates Ups1 dependent phosphatidic acid transfer across lipid bilayers

Sadeqi, F.; Dong, D.; Stroh, K.; Vache, M.; Metz, J.; Riedel, D.; Janshoff, A.; Risselada, H. J.; Kolenda, C.; Meinecke, M.

10.1101/2025.04.03.647039 — biochemistry — Posted on 2025-04-04

4526 Disease-causing MFN2 mutants impair mitochondrial fission dynamics by distinct DRP1 dysregulation

Eisner, V. R.; Lagos, D.; de Santiago, P. R.; Perez, N.; Cartes-Saavedra, B.; Vial-Brizzi, J.; Podmanicky, O.; Horvath, R.

10.1101/2025.04.03.647131 — cell biology — Posted on 2025-04-04

4527 Dysregulated Gene Regulatory Networks in Substance Use Disorder and HIV Infection: Insights from Single-Cell Genomics

Ren, J.; Chen, Y.; Ho, W.-z.; Wei, Z.

10.1101/2025.03.31.646265 — systems biology — Posted on 2025-04-04

4528 Target engagement studies and kinetic live-cell degradation assays enable the systematic characterization of HDAC6 PROTACs at endogenous protein expression levels

Hanl, M.; Feller, F.; Honin, I.; Tan, K.; Schaeker-Huebner, L.; Bueckreiss, N.; Schiedel, M.; Guetschow, M.; Bendas, G.; Hansen, F. K.

10.1101/2025.03.31.646177 — pharmacology and toxicology — Posted on 2025-04-04

4529 Field potential Imaging in human iPSC- derived Cardiomyocytes using UHD-CMOS-MEA

Matsuda, N.; Nagafuku, N.; Matsuda, K.; Ishibashi, Y.; Taniguchi, T.; Matsushita, Y.; Miyamoto, N.; Yoshinaga, T.; Suzuki, I.

10.1101/2025.03.31.646249 — pharmacology and toxicology — Posted on 2025-04-04

4530 Integration of nuclear morphology and 3D imaging to profile cellular neighborhoods

Forjaz, A.; Kramer, D.; Shen, Y.; Bea, H.; Tsapatsis, M.; Ping, J.; Queiroga, V.; Han, K. S.; Joshi, S.; Grubel, C.; Beery, M. L.; Kusmartseva, I.; Atkinson, M. A.; Kiemen, A. L.; Wirtz, D.

10.1101/2025.03.31.646356 — bioinformatics — Posted on 2025-04-04

4531 Embolization-on-a-chip: Novel Vascularized Liver Tumor Model for Evaluation of Cellular and Cytokine Response to Embolic Agents

Nguyen, H. T.; Tirpakova, Z.; Peirsman, A.; Maity, S.; Falcone, N.; Kawakita, S.; Khorsandi, D.; Rashad, A.; Farhadi, N.; Mandal, K.; Ermis, M.; Herculano, R. D.; Najafabadi, A. H.; Dokmeci, M. R.; Barros, N. R. D.; Khademhosseini, A.; Jucaud, V.

10.1101/2025.03.30.646225 — bioengineering — Posted on 2025-04-04

4532 A non-canonical cGAS-STING pathway drives cellular and organismal aging

Cancado de Faria, R.; Silva, L.; Teodoro-Castro, B.; McCommis, K. S.; Shashkova, E. V.; Gonzalo, S.

10.1101/2025.04.03.645994 — cell biology — Posted on 2025-04-04

4533 Integrative Analysis of EGF, OSM, and TGFB Signaling Pathways Reveals Synergistic Mechanisms Driving Cell Motility Through CXCR2 Chemotactic Signaling and CREB Activation

McLean, I. C.; Gross, S.; Copperman, J.; Derrick, D.; Heiser, L.

10.1101/2025.04.03.647095 — cell biology — Posted on 2025-04-04

4534 The Second Mitochondrial Activator of Caspases (SMAC) regulates growth, inflammation and mitochondrial integrity in cancer cells

Amer, T.; Haimovici, A.; Kirschnek, S.; Vier, J.; Moeed, A.; Ukachukwu, U.; Helmstaedter, M.; Kayser, S.; Oellinger, R.; Rad, R.; Weber, A.; Badr, M. T.; Haecker, G.

10.1101/2025.04.03.646995 — cell biology — Posted on 2025-04-04

4535 STAR/STARD1: a mitochondrial intermembrane space cholesterol shuttle degraded through mitophagy

Koganti, P. P.; Zhao, A. H.; Kern, M. C.; Fassinou, A. C. R.; Selvaraj, V.

10.1101/2025.04.03.647084 — cell biology — Posted on 2025-04-04

4536 Non-canonical HIPPO-MST1/2 promotes hyper-proliferation of pulmonary vascular cells through CDC20

Dey, T.; Zhyvylo, I.; Jiang, L.; Olapoju, S. O.; Pena, A.; Avolio, T.; Lin, D.; Goncharov, D.; Greenland, J. R.; Wolters, P. J.; DeLisser, H.; Pullamsetti, S. S.; Kudryashova, T. V.; Goncharova, E. A.

10.1101/2025.04.03.646845 — cell biology — Posted on 2025-04-04

4537 NHSL3 interacts with Ena/VASP proteins and the Scar/WAVE complex and promotes cell migration.

Pallett, T.; Mosis, F.; Poland, S.; Ameer-Beg, S.; Krause, M.

10.1101/2025.04.03.647056 — cell biology — Posted on 2025-04-04

4538 CIP2A is required for mitotic recruitment of the SLX1/XPF/MUS81 tri-nuclease complex to replication stress-induced DNA lesions to maintain genome integrity

de Haan, L.; Dijt, S.; Lopez, A. G.; Ruan, D.; Bakker, F.; Everts, M.; Warner, H.; Mol, F. N.; de Boer, R.; Huis in 't Veld, P.; van de Kooij, B.; Vlijm, R.; van Vugt, M.

10.1101/2025.04.03.647079 — cell biology — Posted on 2025-04-04

4539 Gangliosides Modulate the Secretion of Extracellular Vesicles and Their Misfolded Protein Cargo

Monyror, J.; Kadam, V.; Morales, L. C.; Ordonez, D.; Ibanga, J.; Zaidi, A.; McNamara, E.; Pink, D.; Stenlund, M.; Reyes, K.; Maguire, A. D.; Huang, J.; Cortez, L. M.; Sim, V.; Mok, S.-A.; Posse de Chaves, E.; Sipione, S.

10.1101/2025.04.03.647108 — cell biology — Posted on 2025-04-04

4540 Evolutionary Adaptations of TRPA1 Thermosensitivity and Skin Thermoregulation in Vertebrates

Bertolesi, G. E.; Heshami, N.; McFarlane, S.

10.1101/2025.03.31.646411 — evolutionary biology — Posted on 2025-04-04

4541 Purkinje cell branch morphology determines effect of inhibition and SK2 modulation on somatic pauses

Chou, P.-J.; De Schutter, E.; Cirtala, G.

10.1101/2025.03.31.646261 — neuroscience — Posted on 2025-04-04

4542 Forecasting drug resistant HIV protease evolution

Aggarwal, M.; Periwal, V.

10.1101/2025.03.31.646462 — systems biology — Posted on 2025-04-04

4543 A statistical framework for inferring genetic requirements from embryo-scale single-cell sequencing experiments

Duran, M.; Barkan, E. R.; Tresenrider, A.; Lee, H.; Friedman, R. Z.; Lammers, N.; Colon, M.; Franks, J.; Ewing, B.; Kimelman, D.; Trapnell, C.

10.1101/2025.04.03.646654 — bioinformatics — Posted on 2025-04-04

4544 HyDrop v2: Scalable atlas construction for training sequence-to-function models

Dickmanken, H.; Wojno, M.; Theunis, K.; Eksi, E. C.; Mahieu, L.; Christiaens, V.; Kempynck, N.; De Rop, F. V.; Roels, N.; Spanier, K. I.; Vandepoel, R.; Hulselmans, G. J.; Poovathingal, S.; Aerts, S.

10.1101/2025.04.02.646792 — bioinformatics — Posted on 2025-04-04

4545 Chromatin as a Coevolutionary Graph: Modeling the Interplay of Replication with Chromatin Dynamics

Korsak, S.; Banecki, K.; Buka, K.; Gorski, P. J.; Plewczynski, D.

10.1101/2025.03.31.646315 — bioinformatics — Posted on 2025-04-04

4546 Predicting microsatellite instability from whole slide images using texture features

Swanson, N.; Castro, M. A. A.; Robertson, A. G.; Shmulevich, I.; Tercan, B.

10.1101/2025.03.30.646246 — bioinformatics — Posted on 2025-04-04

4547 Comparison and Optimization of Cellular Neighbor Preference Methods for Quantitative Tissue Analysis

Schiller, C.; Ibarra-Arellano, M. A.; Bestak, K.; Tanevski, J.; Schapiro, D.

10.1101/2025.03.31.646289 — bioinformatics — Posted on 2025-04-04

4548 SPDEv3.0: A Multidisciplinary Integrated Data Analysis Platform

Xu, D.

10.1101/2025.03.30.646234 — bioinformatics — Posted on 2025-04-04

4549 Inverse signal importance in real exposome: How do biological systems dynamically prioritize multiple environmental signals?

Itoh, T.; Kondo, Y.; Nakayama, T.; Shinomiya, A.; Aoki, K.; Yoshimura, T.; Naoki, H.

10.1101/2025.03.31.646257 — bioinformatics — Posted on 2025-04-04

4550 High-throughput RNA and Single-cell RNA Sequencing to Identify Sepsis associated Molecular Mechanisms and the Blood Immune Cell Landscape

Cheng, D.; Wenjun, L.

10.1101/2025.03.31.646322 — bioinformatics — Posted on 2025-04-04

4551 Neural stem cell epigenomes and fate bias are temporally coordinated during corticogenesis

Shapira, Y.; Noack, F.; Vangelisti, S.; Chong, F.; Lifshitz, A.; Tanay, A.; Bonev, B.

10.1101/2025.04.03.647013 — genomics — Posted on 2025-04-04

4552 Quantifying the influence of genetic context on duplicated mammalian genes

Moffett, A. S.; Falcon-Cortes, A.; Di Pierro, M.

10.1101/2025.04.03.647042 — evolutionary biology — Posted on 2025-04-04

4553 Genetic structure of sugar kelp in the St. Lawrence Estuary and Gulf (Quebec, Canada)

Treillefort, M.; Le Cam, S.; Valero, M.; Mauger, S.; Ruggieri, P.; Salvo, F.; Gendron-Lemieux, I.; Provencher, T.; Belley, R.; Dufresne, F.

10.1101/2025.04.01.646547 — evolutionary biology — Posted on 2025-04-04

4554 Whole-genome duplication reshapes adaptation: autotetraploid Arabidopsis arenosa leverages its high genetic variation to compensate for selection constraints.

Celestini, S.; Lipanova, V.; Vlcek, J.; Kolar, F.

10.1101/2025.04.01.646563 — evolutionary biology — Posted on 2025-04-04

4555 Embryo-scale single-cell chemical transcriptomics reveals dependencies between cell types and signaling pathways

Barkan, E.; Duran, M.; Lammers, N.; Tresenrider, A.; Jackson, D.; Lee, H.; Haagen, B.; Saunders, L.; Abitua, P.; Kimelman, D.; Trapnell, C.

10.1101/2025.04.03.646423 — developmental biology — Posted on 2025-04-03

4556 Novel multi-transmitter calyx-like giant synapse revealed in the extended amygdala

Zhang, L.; Hernandez, V.; Giraldo, D. M.; Leon-Contreras, J. C.; Ye, R.; Zhang, S.; Schafer, M. K.-H.; barrio, r.; Hernandez-Pando, R.; Ferraguti, F.; Eiden, L. E.

10.1101/2025.04.03.647119 — neuroscience — Posted on 2025-04-04

4557 Field Survey of Anopheles Mosquito and Their Culturable Gut Bacteria in the Border Regions of Yunnan Province, China

Fan, G.; Yang, W.; Ding, C.; Tian, P.; Wang, J.; Liu, F.; Yang, Y.

10.1101/2025.04.02.645363 — microbiology — Posted on 2025-04-03

4558 High-Level Expression, Purification and Biophysical Characterization of GPI-anchored native-like human Prion Protein using Leishmania tarentolae

Bolakhrif, N.; Pauly, T.; Nagel, L.; Willbold, D.; Gremer, L.

10.1101/2025.03.30.646161 — biophysics — Posted on 2025-04-03

4559 Deciphering complex interactions between LTR retrotransposons and three Papaver species using LTR_Stream

Xu, T.; Bush, S. J.; Che, Y.; Zhao, H.; Wang, T.; Jia, P.; Wang, S.; Sun, P.; Zhang, P.; Gao, S.; Xu, Y.; Wang, C.; Dang, N.; Zhang, Y.; Yang, X.; Ye, K.

10.1101/2025.03.30.646164 — bioinformatics — Posted on 2025-04-03

4560 Exquisite specificity of Pks13 defines the essentiality of trehalose in mycobacteria

Chen, Y.; Lim, J. D. T.; Chng, S.-S.

10.1101/2025.04.03.647003 — biochemistry — Posted on 2025-04-03

4561 Blaming Luck, Claiming Skill: Self-Attribution Bias in Error Assignment

Okamoto, N.; Taylor, M.; Kubo, T.; Ishii, S.; De Martino, B.; Cortese, A.

10.1101/2025.03.18.644058 — animal behavior and cognition — Posted on 2025-04-03

4562 What are the best practices for curating eDNA custom barcode reference libraries? A case study using Australian subterranean fauna.

Guzik, M.; Stringer, D.; Thornhill, J.; Coates, P. J.; van der Heyde, M.; Hillyer, M.; White, N. E.; Sacco, M.; Beasley-Hall, P. G.; Humphreys, W. F.; Harvey, M. S.; Huey, J. A.; Wilson, N. G.; Alexander, J.; Humphreys, G.; King, R. A.; Cooper, S. J. B.; Pinder, A.; Perina, G.; Hosie, A. M.; Kirkendale, L.; Nevill, P.; Austin, A.

10.1101/2024.09.18.611555 — evolutionary biology — Posted on 2025-04-03

4563 Climate-driven mangrove dieback and recovery: a case study in Albert and Leichhardt Rivers, Australia

Goncalves, R. V. S.; Asbridge, E.; Kelleway, J. J.; Lucas, R.; Rogers, K.

10.1101/2025.03.30.646221 — ecology — Posted on 2025-04-03

4564 OPUS-TOMO: Deep Learning Framework for Structural Heterogeneity Analysis in Cryo-electron Tomography

Luo, Z.; Chen, X.; Wang, Q.; Ma, J.

10.1101/2024.06.30.601442 — molecular biology — Posted on 2025-04-03

4565 An Experimental and Multiphysics Simulations Study of Clostridium carboxidivorans sp. 624 for Acid and Alcohol Production in CO2/H2

Tiong, Y. W.; Yong, A.; Nalaparaju, A.; Nguyen, H.-H.; Koh, L. Q.; Wong, R. J.; Lim, R. T. Y.; Ow, D. S.-W.; Zhang, J.; Nguyen, V. B.; Wong, F. T.; Lim, Y. H.

10.1101/2025.02.24.639814 — microbiology — Posted on 2025-04-03

4566 Serotonin modulation of metabolism and stress response in Pseudomonas fluorescens

Waclawikova, B.; Schwalbe, M.; Ilyaskina, D.; Toptas, S.; Thome, N. U.; Elsayed, S. S.; de Jong, A.; van Wezel, G. P.; El Aidy, S.

10.1101/2025.04.03.646968 — microbiology — Posted on 2025-04-03

4567 Native metabolomics identifies pteridines as CutA ligands and modulators of copper binding

Wagner, B. C.; Geibel, C.; Stadelmann, A.; Rapp, J.; Link, H.; Nussbaum, E.; Grenzendorfer, H.-P.; Albrecht, R.; Hartmann, M. D.; Forchhammer, K.; Selim, K. A.; Hughes, C. C.; Petras, D.

10.1101/2025.04.03.647050 — microbiology — Posted on 2025-04-03

4568 Genomic characterization and enhanced fermentation of the endophyte Stemphylium sp. (Aa22), a producer of bioactive alkyl-resorcinols

Rojas Lopez-Menchero, J.; Imperial, J.; Andres, M. F.; Diaz, C. E.; Gonzalez-Coloma, A.

10.1101/2025.04.02.646934 — microbiology — Posted on 2025-04-03

4569 A gut-selective Axl Inhibitor Attenuates Intestinal Fibrosis in myofibroblast cell models and the Mouse S. Typhimurium Model in vivo

Feng, Y.; Johnson, L. A.; Clasby, M.; Higgins, P.

10.1101/2025.03.30.646118 — immunology — Posted on 2025-04-03

4570 Nucleus accumbens dopamine encodes the trace period during appetitive Pavlovian conditioning

Wanat, M. J.; Garcia-Castaneda, B. I.; Alducin-Martinez, C.; Cedillo, L. G.; Camacho, E. T.; Phillips, P. E. M.

10.1101/2025.01.07.631806 — neuroscience — Posted on 2025-04-03

4571 Discovery and therapeutic exploitation of Master Regulatory miRNAs in Glioblastoma

10.1101/2025.04.01.646663 — cancer biology — Posted on 2025-04-03

4572 Pathogenicity Patterns in Cytochrome P450 Family

Spackova, A.; Kadasova, N.; Varekova, I. H.; Berka, K.

10.1101/2025.03.30.646180 — bioinformatics — Posted on 2025-04-03

4573 3D Printed Molds for Organ-on-a-Chip and Fluidics: PDMS-Based Rapid and Accessible Prototyping

Abbed, R. J.; Cruz, E. I. Q.; Leggett, S. E.

10.1101/2025.03.29.645830 — bioengineering — Posted on 2025-04-03

4574 Pooled scanning of protein variants identifies novel RNA-binding mutants

Tasca, J. A.; Doherty, J. F.; Shields, E. J.; Dissanayaka Mudiyanselage, S.; Reich, L. N.; Sarma, K.; Garcia, B.; Bonasio, R.

10.1101/2025.04.02.646914 — biochemistry — Posted on 2025-04-03

4575 The sialylation pattern of dietary glycopeptides is vital for inhibiting pathogens and modulating gut microbiota in elderly individuals

Zhu, J.; Zhang, T.; Wu, J.; Zhang, H.

10.1101/2025.04.02.646947 — biochemistry — Posted on 2025-04-03

4576 Acquired Amphotericin B Resistance Attributed to a Mutated ERG3 in Candidozyma auris

Massic, L. K.; Doorley, L. A.; Jones, S. J.; Richardson, I.; Siao, D. D.; Siao, L.; Dykema, P.; Hua, C. N.; Schneider, E.; Cuomo, C. A.; Rogers, P. D.; Van Hooser, S.; Parker, J.; Kelly, S. L.; Hess, D.; Rybak, J. M.; Pandori, M. W.

10.1101/2025.03.30.646105 — genetics — Posted on 2025-04-03

4577 A Bayesian filtering method for estimating the fitness effects of nascent adaptive mutations

Kuo, H.-Y.; Kryazhimskiy, S.

10.1101/2025.03.29.646120 — evolutionary biology — Posted on 2025-04-03

4578 Structural basis of a phosphotransferase system xylose transporter

Takahashi, Y. S.; Kohga, H.; Chek, M. F.; Yamamoto, K.; Takahashi, J. F.; Shigematsu, H.; Tanaka, Y.; Ichikawa, M.; Miyazaki, R.; Hakoshima, T.; Tsukazaki, T.

10.1101/2025.04.02.646771 — molecular biology — Posted on 2025-04-03

4579 Autoinduction expression systems by AHL-mediated quorum-sensing circuits in Synechococcus elongatus PCC 7942

Kokarakis, E.; Santos-Merino, M.; Ghaffarinasab, S.; Vocelle, D.; Ducat, D.

10.1101/2025.04.03.647055 — microbiology — Posted on 2025-04-03

4580 Emergence of a New ST617 Hypervirulent Klebsiella pneumoniaewith ESBL+ and Strong Biofilm Forming Ability in China

Yu, Y.; Dong, X.; Xiang, Y.; LI, Y.; Bi, K.; Liu, J.; Sun, L.; Wu, T.; Zhang, Y.

10.1101/2025.04.03.646950 — microbiology — Posted on 2025-04-03

4581 A biofilm activator MmtA1 modulates multi-drug resistance in mycobacteria

Hu, J.; Gao, C.-H.; Yang, M.; Wang, W.

10.1101/2025.04.03.647061 — microbiology — Posted on 2025-04-03

4582 Immune-parenchymal multicellular niches are shared across distinct thyroid autoimmune diseases

Rengarajan, M.; Normand, R.; Tran, H.; Nieman, L. T.; Arnold, B.; Calcaterra, M.; Xu, K. H.; Richieri, P.; Rodriguez, E. E.; Slowikowski, K.; Song, Y.; Tirard, A.; Stephen, A. E.; Sadow, P. M.; Parangi, S.; Daniels, G. H.; Luster, A. D.; Villani, A.-C.

10.1101/2025.03.30.646176 — immunology — Posted on 2025-04-03

4583 Resting-state is not enough: alpha and mu rhythms change shape across development, but lack diagnostic sensitivity

Bender, A.; Voytek, B.; Schaworonkow, N.

10.1101/2023.10.13.562301 — neuroscience — Posted on 2025-04-03

4584 Characterization and orthogonality assessment of two quorum sensing systems for synthetic biology applications

De Baets, J.; De Paepe, B.; De Mey, M.

10.1101/2025.04.03.643276 — synthetic biology — Posted on 2025-04-03

4585 Vascular niches are the primary hotspots for aging within the multicellular architecture of cardiac tissue

Rodriguez Morales, D.; Larcher, V.; Ruz Jurado, M.; Tombor, L.; Zanders, L.; Wagner, J. U. G.; Zeiher, A. M.; Kuppe, C.; John, D.; Schulz, M. H.; Dimmeler, S.

10.1101/2025.03.30.646237 — physiology — Posted on 2025-04-03

4586 Deciphering spatiotemporal patterns of rhizodeposition with a functional-structural root model: RhizoDep

Rees, F.; Gerault, T.; Gauthier, M.; Barillot, R.; Richard-Molard, C.; Jullien, A.; Chenu, C.; Pradal, C.; Andrieu, B.

10.1101/2025.03.30.646173 — physiology — Posted on 2025-04-03

4587 WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response

Tjeerdsma, R. B.; Ng, T.; Roorda, M.; Bianchi, D.; Yang, S.; Bonnet, C.; VanInsberghe, M.; Everts, M.; Bakker, F.; de Boer, R.; Moatti, N.; Hustedt, N.; Yin, J.; Hoeg, L.; Leibovitch, M.; Sicheri, F.; van Oudenaarden, A.; de Jong, S.; van den Berg, J.; Tanenbaum, M. E.; Brummelkamp, T. R.; Durocher, D.; van Vugt, M.

10.1101/2025.03.12.642754 — cancer biology — Posted on 2025-04-03

4588 Revealing molecular determinants of ligand efficacy and affinity at the D2 dopamine receptor through molecular dynamics simulations

Chen, Y.; Kahlous, N. A.; Saarinen, M.; Conesa, S. P.; Svenningsson, P.; Delemotte, L.; Carlsson, J.

10.1101/2025.03.30.646192 — biophysics — Posted on 2025-04-03

4589 Computational design of constitutively active mutants of Dopamine D2 receptor inspired by ligand-independent activation mechanisms

Chen, Y.; Saarinen, M.; Naraine, A.; Carlsson, J.; Svenningsson, P.; Delemotte, L.

10.1101/2025.03.30.646255 — biophysics — Posted on 2025-04-03

4590 Intracochlear pressure measurements quantify overall noise exposure to the inner ear during mastoidectomy

Bacalao, E.; Lee, N.; Ruiz, J.; Herrmann, B.; Greene, N. T.

10.1101/2025.03.30.646193 — bioengineering — Posted on 2025-04-03

4591 Effect of the S2' site cleavage on SARS-CoV-2 spike

Shi, W.; Jonaid, G.; Kibria, M. G.; Allen, J.; Peng, H.; Rits-Volloch, S.; Zhu, H.; Wang, S.; Walsh, R. M.; Lu, J.; Chen, B.

10.1101/2025.04.02.646838 — biochemistry — Posted on 2025-04-03

4592 Defining effective strategies to integrate multi-sample single-nucleus ATAC-seq datasets via a multimodal-guided approach

Weinand, K.; Langan, E. M.; Curtis, M.; Raychaudhuri, S.

10.1101/2025.04.02.646871 — genomics — Posted on 2025-04-03

4593 A Telomere-to-Telomere Diploid Reference Genome and Centromere Structure of the Chinese Quartet

Wang, B.; Jia, P.; Bush, S. J.; Wang, X.; Yang, Y.; Zhang, Y.; Wan, S.; Yang, X.; Zhang, P.; Zheng, Y.; Shi, L.; Dong, L.; Ye, K.

10.1101/2025.03.30.646227 — genomics — Posted on 2025-04-03

4594 Causal inference for multiple risk factors and diseases from genomics data

Machnik, N.; Mahmoudi, M.; Borczyk, M.; Kraetschmer, I.; Bauer, M. J.; Robinson, M. R.

10.1101/2023.12.06.570392 — genetics — Posted on 2025-04-03

4595 Superoxide Dismutases maintain niche homeostasis in stem cell populations

Majhi, O.; Chhatre, A.; Chaudhary, T.; Sinha, D.

10.1101/2023.12.06.570086 — developmental biology — Posted on 2025-04-03

4596 BLTP3A is associated with membranes of the late endocytic pathway and is an effector of CASM

Hanna, M. G.; Rodriguez Cruz, H. O.; Fujise, K.; Wu, Y.; Xu, C. S.; Pang, S.; Zhuoning, L.; Monetti, M.; De Camilli, P.

10.1101/2024.09.28.615015 — cell biology — Posted on 2025-04-03

4597 Inherent Specificity and Mutational Sensitivity as Quantitative Metrics for RBP Binding

Yi, S.; Singh, S. S.; Ye, X.; Krishna, R.; Jankowsky, E.; Luna, J. M.

10.1101/2025.03.28.646018 — molecular biology — Posted on 2025-04-03

4598 H3K27 and H3K9 Methylation Mask Potential CTCF Binding Sites to Maintain 3D Genome Integrity

Fukuda, K.; Shinkai, Y.; Shimura, C.

10.1101/2025.04.02.646724 — molecular biology — Posted on 2025-04-03

4599 The leading region of many conjugative plasmids is depleted in restriction-modification targets

Shaw, L. P.; Celis, A. P.; Arroyo, M. A.; Luo, L.; Dimitriu, T.; de la Cruz, F.

10.1101/2025.04.03.647016 — microbiology — Posted on 2025-04-03

4600 Genomic epidemiology reveals antibiotic resistance transfer and polyclonal dissemination of Acinetobacter baumannii in a Paraguayan hospital

Bello-Lopez, E.; Kawabata, A.; Cantero, J.; Mendoza, S.; Pertile, E.; Perez-Osegura, A.; Cevallos, M. A.; Peralta, H.; Aguilar-Vera, A.; Castillo-Ramirez, S.

10.1101/2025.04.03.647102 — microbiology — Posted on 2025-04-03

4601 High-content assessment of Pseudomonas aeruginosa bacteriophage efficacy reveals host genetic factors involved in phage specificity

Ellward, G. L.; Bucher, M. J.; Zhai, Y.; Munguia, N. S.; Marini, S.; Marsella, R.; Bisesi, J. H.; Montazeri, N.; Cherabuddi, K.; Jeong, K. C.; Czyz, D. M.

10.1101/2025.04.03.646983 — microbiology — Posted on 2025-04-03

4602 Characterizing the Microbiome of 'Sterile' Organs in Experimental Mice

Xu, M.; Guan, S.; Zhong, C.; Ma, M.; Tao, L.; Huang, G.

10.1101/2025.04.02.646907 — microbiology — Posted on 2025-04-03

4603 Establishing an ex vivo porcine skin model to investigate the effects of broad spectrum antiseptic on viable skin microbial communities

Townsend, E. C.; Xu, K.; De La Cruz, K.; Huang, L.; Sandstrom, S.; Meudt, J.; Shanmuganayagam, D.; Huttenlocher, A.; Gibson, A. L. F.; Kalan, L.

10.1101/2025.04.03.647100 — microbiology — Posted on 2025-04-03

4604 Minimal impact of ivermectin on immune response and transcriptional profiles in naïve adults with mild COVID-19

Ribes, M.; Torres, C.; Canyelles, M.; Rubio, R.; Vidal, M.; Izquierdo, L.; Blanco-Di Matteo, A.; Pineda, I.; Fernandez-Montero, A.; Jordan-Iborra, C.; Carmona-Torre, F.; Yuste, J. R.; Del Pozo, J. L.; Reina, G.; Sadaba, B.; Fernandez-Alonso, M.; Santamaria, P.; Carolis, C.; Aguilar, R.; Macia, D.; Chaccour, C.; Dobano, C.; Moncunill, G.

10.1101/2025.03.31.646276 — immunology — Posted on 2025-04-03

4605 The flexible contribution of cortical area V4 to visual perception

Laamerad, P.; Krause, M. R.; Guitton, D.; Pack, C. C.

10.1101/2025.03.11.642616 — neuroscience — Posted on 2025-04-03

4606 A magnitude-independent neural code for linguistic information during sentence production

Morgan, A. M.; Devinsky, O.; Doyle, W.; Dugan, P.; Friedman, D.; Flinker, A.

10.1101/2024.06.20.599931 — neuroscience — Posted on 2025-04-03

4607 Insights into the bioluminescence systems of three sea pens (Cnidaria: Anthozoa): from de novo transcriptome analyses to biochemical assays

Duchatelet, L.; Galeazzo, G. A.; Coubris, C.; Bridoux, L.; Rezsohazy, R.; Melo, M. R. S.; Marek, M.; Amaral, D. T.; Dupont, S.; Oliveira, A. G.; Delroisse, J.

10.1101/2024.04.30.591678 — zoology — Posted on 2025-04-03

4608 Quantifying the Cooperativity of Backbone Hydrogen Bonding

Xu, Y.; Huang, J.

10.1101/2025.03.29.646135 — biophysics — Posted on 2025-04-03

4609 Influenza viral infection at the plasma membrane is restricted by lipid composition

Mannsverk, S.; Villamil Giraldo, A.; Kasson, P.

10.1101/2025.03.28.645900 — biophysics — Posted on 2025-04-03

4610 PiP-plex: A Particle-in-Particle System for Multiplexed Quantification of Secreted Proteins by Single Cells

Lussier, F.; Moon, B.-U.; Janta-Polczynski, M.; Morocz, Y.; Svahn, F.; Shen, M. L.; Lukic, L.; Malic, L.; Veres, T.; Ng, A.; Juncker, D.

10.1101/2025.03.26.645608 — bioengineering — Posted on 2025-04-03

4611 Development of pyrazolopyrimidine based macrocyclic kinase inhibitors targeting AAK1

Mensing, T. E.; Kurz, C. G.; Amrhein, J. A.; Ehret, T. A. L.; Preuss, F.; Mathea, S.; Karim, M.; Tran, D. H. N.; Kadlecova, Z.; Tolvanen, T.; Martinez-Molina, D.; Mueller, S.; Einav, S.; Knapp, S.; Hanke, T.

10.1101/2025.04.02.646796 — biochemistry — Posted on 2025-04-03

4612 High-resolution detection of copy number alterations in single cells with HiScanner

Zhao, Y.; Luquette, L. J.; Veit, A. D.; Wang, X.; Xi, R.; Viswanadham, V. V.; Zhang, Y.; Shao, D. D.; Walsh, C. A.; Yang, H. W.; Johnson, M. D.; Park, P. J.

10.1101/2024.04.26.587806 — genomics — Posted on 2025-04-03

4613 Ancient Trans-Species Polymorphism at the Major Histocompatibility Complex in Primates

Fortier, A. L.; Pritchard, J. K.

10.1101/2022.06.28.497781 — evolutionary biology — Posted on 2025-04-03

4614 On the potential for GWAS with phenotypic population means and allele-frequency data (popGWAS)

Pfenninger, M.

10.1101/2024.06.12.598621 — evolutionary biology — Posted on 2025-04-03

4615 Distinct alpha-synuclein strains derived from Parkinson's disease patient tissues trigger differential inclusion pathology in a novel biosensor cell model

Raina, A.; Wang, W.; Gonzalez, J. C.; Yan, X.; Overstreet-Wadiche, L.; Wadiche, J.; Zhang, C.-L.; Chen, S. G.

10.1101/2025.04.01.646513 — neuroscience — Posted on 2025-04-03

4616 Perinatal Elimination of Genetically Aberrant Neurons from Human Cerebral Cortex

Shao, D. D.; Zhao, Y.; Brew, J.; Ghosh, U.; Luquette, L. J.; Zhao, S.; Kriz, A. J.; Qian, X.; Viswanadham, V. V.; Taketomi, T.; Tsuruta, F.; Park, P. J.; Walsh, C. A.

10.1101/2024.10.08.617159 — neuroscience — Posted on 2025-04-03

4617 ABERRANT NEURAL ADAPTATION TO EXPECTED UNCERTAINTY IN ADULTS WITH AUTISM SPECTRUM DISORDER

Pultsina, K.; Kozunova, G.; Chernyshev, B.; Prokofyev, A.; Tretyakova, V.; Novikov, A.; Rytikova, A.; Stroganova, T.

10.1101/2025.03.30.646160 — neuroscience — Posted on 2025-04-03

4618 Brainwide genetic capture for conscious state transitions

Lazaro, H.; Schneider, K. N.; Jin, M.; Beck, A.; Rijsketic, D. R.; Murry, A. D.; Navarrete, J.; Shin, C. C.; Barrow, A. C.; Campuzano, I.; Nota, M. H.; Ressler, N.; Apley, E.; Zhang, J.; Gutierrez, G.; Szelenyi, E. R.; Nilsson, S. R.; Denny, C. A.; Bruchas, M. R.; Heifets, B. D.; de la Iglesia, H. O.; Golden, S. A.; Heshmati, M.

10.1101/2025.03.28.646066 — neuroscience — Posted on 2025-04-03

4619 Synaptic Connectivity of Sensorimotor Circuits for Vocal Imitation in the Songbird

Trusel, M.; Zhao, Z.; Alam, D.; Marks, E.; Ikeda, M.; Roberts, T. F.

10.1101/2022.11.08.515692 — neuroscience — Posted on 2025-04-03

4620 DNA Specimen Preservation using DESS and DNA Extraction in Museum Collections: A Case Study Report

Ogiso-Tanaka, E.; Shimada, D.; Ogawa, A.; Ishiyama, G.; Okumura, K.-i.; Hosaka, K.; Ishii, C.; Nam, K. O.; Hoshino, M.; Nomura, S.; Kakizoe, S.; Nakamura, Y.; Nishiumi, I.; Ito, M. A.; Kitayama, T.; Tanaka, N.; Hosoya, T.; Jinbo, U.

10.1101/2025.03.30.646169 — zoology — Posted on 2025-04-03

4621 Optically driven control of mechanochemistry and fusion dynamics of biomolecular condensates via thymine dimerization

Sheikhhassani, V.; Wong, F. F. H. K.; Bonn, D.; Schmit, J. D.; Mashaghi, A.

10.1101/2025.03.30.646143 — biophysics — Posted on 2025-04-03

4622 Cationic amino acid identity and net charge influence condensate properties in E. coli

Kidane, A. K.; Rosenfeld, J. R.; Johnston, J. D.; Dubbeldam, C.; Paraan, M.; Obermeyer, A. C.

10.1101/2025.03.29.646054 — biophysics — Posted on 2025-04-03

4623 SpaceBF: Spatial coexpression analysis using Bayesian Fused approaches in spatial omics datasets

Seal, S.; Neelon, B.

10.1101/2025.03.29.646124 — bioinformatics — Posted on 2025-04-03

4624 Learning interpretable representation for context-specific transcription regulatory networks using a foundation model

Zhang, Y.; Yu, Z.; Yang, D.; Chen, Q.; Zhang, Y.; Li, Z.; Wang, Y.; Wang, C.

10.1101/2025.03.29.646077 — bioinformatics — Posted on 2025-04-03

4625 Multi-alignment framework - Consider and analyse genomic and transcriptomic alignment variability and read count distributions by comparing different techniques.

Zhao, X.; Korsching, E.

10.1101/2025.02.18.638849 — bioinformatics — Posted on 2025-04-03

4626 Paired Analyses of Nuclear Protein Targets and Genomic DNA by Single-Cell Western Blot and Single-Cell PCR

Gomez Martinez, A. E.; Lam, T.; Herr, A.

10.1101/2025.03.29.646125 — bioengineering — Posted on 2025-04-03

4627 Estimating Brain Similarity Networks with Diffusion MRI

Sadikov, A.; Choi, H.; Cai, L. T.; Mukherjee, P.

10.1101/2025.03.29.646134 — neuroscience — Posted on 2025-04-03

4628 Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau

Santambrogio, A.; Lovestam, S.; Metrick, M. A.; Lohr, T. S.; Xu, P.; Caughey, B.; Scheres, S.; Vendruscolo, M.

10.1101/2025.03.29.646137 — neuroscience — Posted on 2025-04-03

4629 Using an ODE model to separate Rest and Task signals in fMRI

Kashyap, A.; Geenjaar, E. P. T.; Bey, P.; Dhindsa, J.; Glomb, K.; Plis, S.; Keilholz, S.; Ritter, P.

10.1101/2023.10.23.563564 — neuroscience — Posted on 2025-04-03

4630 Gene expression patterns decompose fMRI activation in a sub-region-specific manner in mice after nociceptive stimulation

Wank, I.; Amthor, A.; Kreitz, S.; Haefele, M.; Hess, A.

10.1101/2025.04.01.646627 — neuroscience — Posted on 2025-04-03

4631 Long-term memory reorganization of navigational episodes

Iggena, D.; Schmelter, T.; Maier, P. M.; Requieg, K.; Finke, C.; Hildebrand, K.; Ploner, C. J.

10.1101/2025.04.01.646566 — neuroscience — Posted on 2025-04-03

4632 Methods to assess neuronal primary cilia electrochemical signaling.

DeCaen, P. G.; Kimura, L. F.

10.1101/2025.04.01.646689 — neuroscience — Posted on 2025-04-03

4633 Targeting therapeutic nanoparticles to the glioblastoma resection margin by harnessing post-operative spatiotemporal blood-brain barrier disruption

Fernandes, L. F.; Peeyatu, C.; Dickie, B. R.; Ho, Y. S.; Thompson, L. A.; Hernandez, N.; Lozano, N.; Kostarelos, K.; Kisby, T.

10.1101/2025.03.29.646102 — pharmacology and toxicology — Posted on 2025-04-03

4634 Extending differential gene expression testing to handle genome aneuploidy in cancer

Davydzenka, K.; Caravagna, G.; Sanguinetti, G.

10.1101/2025.03.29.646108 — bioinformatics — Posted on 2025-04-03

4635 TRUHiC: A TRansformer-embedded U-2 Net to enhance Hi-C data for 3D chromatin structure characterization

Li, C.; Mowlaei, M. E.; Human Genome Structural Variation Consortium, ; HGSVC Functional Analysis Working Group, ; Carnevale, V.; Kumar, S.; Shi, X.

10.1101/2025.03.29.646133 — bioinformatics — Posted on 2025-04-03

4636 Advancing EEG Biosensing: Novel Scalable Production of Platinum-Silicon Microneedles

Amir, M.; Ding, R.; Rusli, N. I.; Vercooren, N.; Ceyssens, F.; Kuznetsova, N.; Bertrand, A.; Kraft, M.; Taurino, I.

10.1101/2025.03.29.646121 — bioengineering — Posted on 2025-04-03

4637 A Novel Aptamer-Based Approach for Lipoprotein Removal to Achieve Ultra-Pure Blood EV Isolation

Jeon, S.; Kim, Y.; SHIN, S.

10.1101/2025.03.29.646082 — bioengineering — Posted on 2025-04-03

4638 SMAdd-seq: Probing chromatin accessibility with small molecule DNA intercalation and nanopore sequencing

Bai, G.; Dhillon, N.; Felton, C. A.; Meissner, B.; Saint-John, B.; Shelansky, R.; Meyerson, E.; Hrabeta-Robinson, E.; Hodjat, B.; Boeger, H.; Brooks, A. N.

10.1101/2024.03.20.585815 — genomics — Posted on 2025-04-03

4639 MarpolBase: Genome database for Marchantia polymorpha featuring high quality reference genome sequences

Tanizawa, Y.; Mochizuki, T.; Yagura, M.; Sakamoto, M.; Fujisawa, T.; Kawamura, S.; Shimokawa, E.; Yamaoka, S.; Nishihama, R.; Bowman, J. L.; Berger, F.; Yamato, K.; Kohchi, T.; Nakamura, Y.

10.1101/2025.03.30.646155 — genomics — Posted on 2025-04-03

4640 Microtubule depolymerization at kinetochores restricts anaphase spindle elongation

Chen, G.-Y.; Deng, C.; Chenoweth, D. M.; Lampson, M. A.

10.1101/2024.08.30.610502 — cell biology — Posted on 2025-04-03

4641 The SET1/COMPASS subunit RBBP5 orchestrates epigenetic control of global proteostasis and the 12h oscillator to safeguard metabolic and cellular homeostasis

Kubra, S.; Sun, M.; Dion, W.; Catak, A.; Luong, H.; Wang, H.; Pan, Y.; Liu, J.-J.; Ponna, A.; Sipula, I.; Jurczak, M. J.; Liu, S.; Zhu, B.

10.1101/2024.09.13.612812 — cell biology — Posted on 2025-04-03

4642 OPUS-TOMO: Deep Learning Framework for Structural Heterogeneity Analysis in Cryo-electron Tomography

Luo, Z.; Chen, X.; Wang, Q.; Ma, J.

10.1101/2024.06.30.601442 — molecular biology — Posted on 2025-04-03

4643 Hypothermia protects against ventilator-induced lung injury by limiting IL-1β release and NETs formation

Nosaka, N.; Borges, V.; Martinon, D.; Crother, T. R.; Arditi, M.; Shimada, K.

10.1101/2024.09.02.610778 — immunology — Posted on 2025-04-03

4644 Cellular morphodynamics as quantifiers for functional states of resident tissue macrophages in vivo

Schnitzerlein, M.; Greto, E.; Wegner, A.; Möller, A.; Aust, O.; Ben Brahim, O.; Uderhardt, S.; Zaburdaev, V.

10.1101/2024.01.24.577158 — immunology — Posted on 2025-04-03

4645 A slow and clathrin-dependent mode of compensatory endocytosis in hippocampal boutons at near-physiological temperature

Klingauf, J.; Kahms, M.; Pandey, S.

10.1101/2025.03.31.646354 — neuroscience — Posted on 2025-04-03

4646 Derepression of transposable elements in mouse prefrontal cortex disrupts social behavior

Kim, R. K.; Smith, C.; Truby, N. L.; Carwile, N.; Silva, G. M.; Neve, R. L.; Cui, X.; Hamilton, P. J.

10.1101/2025.03.31.646358 — neuroscience — Posted on 2025-04-03

4647 Metabolic Alteration in Oxylipins and Endocannabinoids Point to an Important Role for Soluble Epoxide Hydrolase and Inflammation in Alzheimer's Disease - Finding from Alzheimer's Disease Neuroimaging Initiative.

Borkowski, K.; Yin, C.; Kindt, A.; Liang, N.; de Lange, E. C. M.; Blach, C.; Newman, J.; Kaddurah-Daouk, R.; Hankemeier, T.; Alzheimer's Disease Metabolomics Consortium, ; Alzheimer's Disease Neuroimaging Initiative,

10.1101/2025.04.01.646677 — neuroscience — Posted on 2025-04-03

4648 Linking Pregnancy- and Birth-Related Factors to a Multivariate Fusion of Child Cortical Structure

Lindseth, L. R.; Beck, D.; Westlye, L. T.; Tamnes, C. K.; Norbom, L. B.

10.1101/2024.10.29.620834 — neuroscience — Posted on 2025-04-03

4649 Novel dopaminergic neurotransmission in the Octopus visual system

Courtney, A.; Styfhals, R.; Van Dijck, M.; Boulanger, J.; Geenen, L.; Lanoizelet, M.; Hardege, I.; Lassnig, M.; Jansson, A. M.; Gehler-Rahman, J.; Almansa, E.; Obenhaus, H.; Seuntjens, E.; Schafer, W. R.

10.1101/2025.04.02.646353 — neuroscience — Posted on 2025-04-03

4650 Coordinated IFN-γ/TNF Axis Drives Selective Loss of Activated Enteric Glia in Inflammatory Bowel Diseases

Bubeck, M.; Penkert, K. A.; Limberger, H.; Gonzalez Acera, M.; Plattner, C.; Ziegler, S.; Muppirala, A. N.; Forster, P.; Jakob, M.; Gamez-Belmonte, R.; Erkert, L.; Kulkarni, S.; Guenther, C.; Atreya, R.; Kuehl, A. A.; Hegazy, A.; Hildner, K.; Trajanoski, Z.; Siegmund, B.; Neurath, M. F.; IBDome Consortium, ; Rao, M.; Progatzky, F. a.; Lie, D. C.; Becker, C.; Romagnani, C.; Ludwig, L. S.; Klose, C. S. N.; Patankar, J. V.

10.1101/2025.04.03.646820 — neuroscience — Posted on 2025-04-03

4651 Real-time spike sorting with 3D neural probe and triangulation localization

Yang, A.-C.; Zhang, J.-H.; Chen, K.-P.; Kao, K. H.; Lee, W.-J.; McLaughlin, M.; Chen, N.-Y.; Sun, J.-J.

10.1101/2025.03.30.645752 — neuroscience — Posted on 2025-04-03

4652 Identifying potential biomarkers of response to CCR5Δ32 HSCT in HIV infection

Chang, J.; Gabhann, F. M.

10.1101/2025.03.30.646188 — systems biology — Posted on 2025-04-03

4653 Improving Protein Interaction Prediction in GenPPi: A Novel Interaction Sampling Approach Preserving Network Topology

William, A.; Godoy, I.; Marquez, C.; Silva, L.; Prado, M.; Avila, N.; Santos, A. R. d.

10.1101/2024.08.16.608332 — bioinformatics — Posted on 2025-04-03

4654 AGO2 slicing of a domesticated retrotransposon is necessary for normal vasculature development

Kumar, M.; Maria, A. G.; Prajapat, M.; Vidigal, J. A.

10.1101/2025.04.02.646793 — developmental biology — Posted on 2025-04-03

4655 Deciphering human heart failure with preserved ejection fraction (HFpEF) at single cell resolution

Zanders, L.; Glaser, S.-F.; Ruz Jurado, M.; Brandt, M. .; John, D.; Nicin, L.; Rodriguez Morales, D.; Abplanalp, W. T.; Procida-Kowalski, T.; Ganss, F.; Ullrich, E.; Debes, A.; Pennoyer, P.; Bartkuhn, M.; Dettmeyer, R. B.; Zeiher, A. M.; Nagel, E.; Wenzel, P.; Dimmeler, S.

10.1101/2025.04.02.646923 — cell biology — Posted on 2025-04-03

4656 Bacteriophage infection drives loss of β-lactam resistance in methicillin-resistant Staphylococcus aureus

Tran, M.; Viera, A. J. H.; Tran, P. Q.; Nilsen, E. D.; Tran, L.; Mo, C.

10.1101/2024.08.19.608629 — microbiology — Posted on 2025-04-03

4657 Expression of human CEACAMs promotes inflammation and organ damage during systemic Candida albicans infection in mice

10.1101/2025.03.29.646107 — immunology — Posted on 2025-04-03

4658 An in vivo CRISPR screen unveils top target genes to efficiently improve CAR-T cell persistence in a solid tumour model of lung adenocarcinoma

Fumagalli, M.; An, D.; Simula, L.; Combe, C.; Aziez, L.; Simoni, Y.; Alves-Guerra, M.-C.; Valentini, A.; Marchais, M.; Vermare, A.; Bercovici, N.; Donnadieu, E.; Pendino, F.

10.1101/2025.03.28.645780 — immunology — Posted on 2025-04-03

4659 Light Impact on Thalamo-Cortical Connectivity During an Executive Cognitive Task: Effects of Time of Day and Specificities of Teenagers

Sharifpour, R.; Campbell, I.; Paparella, I.; Balda, F.; Beckers, E.; Mortazavi, N.; Koshmanova, E.; Read, J.; Collette, F.; Phillips, C.; Talwar, P.; Lamalle, L.; Zubkov, M.; Vandewalle, G.

10.1101/2025.04.03.647005 — neuroscience — Posted on 2025-04-03

4660 Optical recordings of synaptic vesicle fusion reveal diffusional dispersion

Klingauf, J.; Glyvuk, N.; Duan, J.; Krishnan, S.; Tsytsyura, Y.; Keller, U.; Sunil, L. P.; Nosov, G.; Hueve, J.; Selenschik, P.; Reissner, C.; Missler, M.; Kahms, M.

10.1101/2025.03.31.646326 — neuroscience — Posted on 2025-04-03

4661 Dynamics of thalamic directional coding under vestibular imbalance

El Mahmoudi, N.; Huret, A.; Laurent, C.; Laurens, J.; Jacob, P.-Y.; Sargolini, F.

10.1101/2025.03.31.646416 — neuroscience — Posted on 2025-04-03

4662 Transfer entropy predicts pupillary response and cognitive effort during a tracking task

Boylan, S.; Lam, S. Y.; Zenon, A.

10.1101/2025.04.01.646647 — neuroscience — Posted on 2025-04-03

4663 Ion Dynamics Underlying the Seizure Delay Effect of Low-Frequency Electrical Stimulation

Girier, G.; Dallmer-Zerbe, I.; Chvojka, J.; Kudlacek, J.; Jiruska, P.; Hlinka, J.; Schmidt, H.

10.1101/2025.04.01.646594 — neuroscience — Posted on 2025-04-03

4664 Revisiting Free Will: Distributed Activity in the Medial Frontal Cortex Predicts Self-Initiated Action

Pouget, P.; Claron, J.; Blons, M.; Dizeux, A.; Deffieux, T.; Tanter, M.; Berthon, B.

10.1101/2025.04.01.646546 — neuroscience — Posted on 2025-04-03

4665 Stability and Adaptability in Balance: A Dual Mechanism for Metaplasticity in Cortical Networks

Tompos, T.; Zeldenrust, F.; Celikel, T.

10.1101/2025.04.02.646896 — neuroscience — Posted on 2025-04-03

4666 From Lab to Concert Hall: Effects of Live Performance on Neural Entrainment and Engagement

Asthagiri, A.; Loui, P.

10.1101/2025.04.03.646931 — neuroscience — Posted on 2025-04-03

4667 Object categorization based on abstract concepts by monkeys, humans, and vision models

Zhang, H.; Zheng, Z.; Hu, J.; Wang, Q.; Xu, M.; Zhou, Z.; Li, Z.; Okazawa, G.

10.1101/2025.04.02.646407 — neuroscience — Posted on 2025-04-03

4668 New Insights on Bridging Integrator 1 Protein Isoforms as a Risk Increasing Gene in Alzheimer's Disease

Hu, M.; Esmaeeli, S.; Stolzenburg, L.; Jouni, M.; Nyamugenda, E.; Reinhardt, P.; Bahnassawy, L.; Gasparini, L.; Waring, J. F.; Vasanthakumar, A.

10.1101/2025.03.31.646439 — neuroscience — Posted on 2025-04-03

4669 Neutrophil extracellular traps block endogenous and intravenous thrombolysis-induced fibrinolysis in large vessel occlusion acute ischemic stroke

Desilles, J.-P.; compoCLOT study group, ; Solo Nomenjanahary, M.; Perrot, A.; Di Meglio, L.; Zemali, F.; ZALGHOUT, S.; Loyau, S. S.; Labreuche, J.; Bourrienne, M.-C.; Faille, D.; Delvoye, F.; Ollivier, V.; Dupont, S.; ROGOZARSKI, J.; Brikci-Nigassa, N.; Ajzenberg, N.; Mazighi, M.; Ho-Tin-Noe, B.

10.1101/2025.03.28.646062 — pathology — Posted on 2025-04-03

4670 Zinc stimulation of phytoplankton in a low carbon dioxide, coastal Antarctic environment: evidence for the Zn hypothesis

Kell, R. M.; Subhas, A. V.; Schanke, N. L.; Lees, L. E.; Chmiel, R. J.; Rao, D.; Brisbin, M. M. M.; Moran, D. M.; McIlvin, M. R.; Bolinesi, F.; Mangoni, O.; Casotti, R.; Balestra, C.; Horner, T.; Dunbar, R. B.; Allen, A. E.; DiTullio, G. R.; Saito, M. A.

10.1101/2023.11.05.565706 — biochemistry — Posted on 2025-04-03

4671 Sex-biased computations underlying differential set shift performance in mice

Glewwe, N.; Dastin-van Rijn, E. M.; Chen, C. S.; Giglio, E.; Knep, E.; Ebitz, R. B.; Widge, A. S.; Grissom, N. M.

10.1101/2025.04.01.646712 — animal behavior and cognition — Posted on 2025-04-03

4672 Advancing ecological assessment: The integration of eDNA metabarcoding into an estuarine fish index

Bhendarkar, M.; Canals, O.; Jurado, C.; Mendibil, I.; Uriarte, A.; Borja, A.; Rodriguez-Ezpeleta, N.

10.1101/2025.03.31.645977 — ecology — Posted on 2025-04-03

4673 Developmental stages of Arthroleptella villiersi (Pyxicephalidae)

Schweiger, S.; Naumann, B.; Mueller, H.

10.1101/2025.03.31.646409 — developmental biology — Posted on 2025-04-03

4674 Immune surveillance and pruning of neuronal stem cells in the medaka retina

Agarwal, R.; Benjaminsen, J.; Lust, K.; Becker, C.; Fuchs, N.; Hasel de Carvalho, E.; Eggeler, F.; El Said Ibrahim, O.; Aghaallaei, N.; Bajoghli, B.; Wittbrodt, J.

10.1101/2025.04.01.646524 — developmental biology — Posted on 2025-04-03

4675 An intercellular metabolic relay for brain sparingin Drosophila

Franchet, A.; Jin, Y.; Newell, C. L.; Girard, V.; Maniere, G.; Grosjean, Y.; Barrington, C.; MacRae, J. I.; Gilmore, I. S.; Gould, A. P.

10.1101/2025.04.02.645514 — developmental biology — Posted on 2025-04-03

4676 Dentification of the Sorghum TMCO Gene Family and Differential Expression Analysis Under Aphid Infestation

Guan, M.; Ye, C.; Li, J.; Shan, S.; Wang, T.; Wang, Y.; Sun, L.; Du, J.; Wu, D.

10.1101/2025.03.28.646042 — molecular biology — Posted on 2025-04-03

4677 Regulation of transcription elongation anticipates alternative gene expression strategies across the cell cycle

Maya-Miles, D.; Garcia-Martinez, J.; Cases, I.; Pasion, R.; de la Cruz, J.; Perez-Ortin, J. E.; Munoz-Centeno, M. d. l. C.; Chavez, S.

10.1101/2025.01.05.631386 — molecular biology — Posted on 2025-04-03

4678 Neural signatures of motor memories emerge in neural network models

Chang, J.; Clopath, C.; Gallego, J. A.

10.1101/2025.04.02.646788 — neuroscience — Posted on 2025-04-03

4679 Efficient Gaussian Process-based Motor Hotspot Hunting with Concurrent Optimization of TMS Coil Location and Orientation

Schultheiss, D. L.; Turi, Z.; Boedecker, J.; Vlachos, A.

10.1101/2025.04.02.646783 — neuroscience — Posted on 2025-04-03

4680 Tonotopic Specialization of MYO7A Isoforms in Auditory Hair Cells

Li, S.; Park, J.; Phan, T. M.; Egelman, E. H.; Bird, J. E.; Shin, J.-B.

10.1101/2025.04.01.646665 — neuroscience — Posted on 2025-04-03

4681 Anisotropic light propagation in human brain white matter

Pini, E.; Di Meo, D.; Costantini, I.; Sorelli, M.; Bradley, S.; Wiersma, D. S.; Pavone, F. S.; Pattelli, L.

10.1101/2025.04.02.646745 — neuroscience — Posted on 2025-04-03

4682 Neuronal modulation of the superior colliculus associated with visual spatial attention represents perceptual sensitivity, independent of perceptual decision and motor biases

Ghosh, S.; Maunsell, J. H.

10.1101/2025.04.01.646682 — neuroscience — Posted on 2025-04-03

4683 Pumping Up your Predictive Power for Cognitive State Detection with the Proper GAINS

Rodrigues, V. R.; Prieto, J. R.; Beres, S. L.; Stephens, C. L.; Myers, C.; Napoli, N. J.

10.1101/2025.04.01.646685 — neuroscience — Posted on 2025-04-03

4684 Regional susceptibility of PV interneurons in an hAPP-KI mouse model of Alzheimer's disease pathology

Gonzalez, M. M.; Magondu, B.; J Rowan, M.; Forest, C. R.

10.1101/2025.04.01.646485 — neuroscience — Posted on 2025-04-03

4685 Too little and too much: balanced hippocampal, but not medial prefrontal, neural activity is required for intact novel object recognition in rats

Taylor, C. J. L.; Renstrom, J. G.; Loayza, J.; Gwilt, M.; Williams, S. A.; Grasmeder Allen, R.; Moran, P. M.; Gigg, J.; Neill, J.; Harte, M.; Bast, T.

10.1101/2025.04.01.646403 — neuroscience — Posted on 2025-04-03

4686 Performance anxiety is associated with biases in learning from reward and punishment in skilled individuals

Hidalgo, A. E.; Pearson, L.; Oku, T.; Kimoto, Y.; Furuya, S.; Ruiz, M. H.

10.1101/2025.03.31.646422 — neuroscience — Posted on 2025-04-03

4687 Multi-modal Monte Carlo MRI simulator of tissue microstructure

Cottaar, M.; Zheng, Z.; Miller, K.; Tendler, B. C.; Jbabdi, S.

10.1101/2025.04.03.646577 — neuroscience — Posted on 2025-04-03

4688 A formal relation between two disparate mathematical algorithms is ascertained from biological circuit analyses

Liu, C.; Bowen, E. F.; Granger, R.

10.1101/2025.03.28.645962 — neuroscience — Posted on 2025-04-03

4689 Localization of AP2α2, TRPV1 and PIEZO2 to the Large Dense Core Vesicles of Human Dorsal Root Ganglion Neurons

Joshi, O.; Cooper, A.; Powell, R.; Martin, M. K.; Rodriguez, R.; Kuechle, J. B.; Bhattacharjee, A.

10.1101/2025.03.31.646357 — neuroscience — Posted on 2025-04-03

4690 iNeurons are sweet, maybe too sweet? Exploring the impact of media composition on PINK1-dependent mitophagy

O'Callaghan, B.; Melandri, D.; Soltic, D.; Cosker, K.; Soutar, M. P. M.; Plun-Favreau, H.

10.1101/2025.04.01.646648 — neuroscience — Posted on 2025-04-03

4691 Human-like monocular depth biases in deep neural networks

Kubota, Y.; Fukiage, T.

10.1101/2025.04.03.646971 — neuroscience — Posted on 2025-04-03

4692 Impact of Cesarean Delivery on Reward Behavior and Neurodevelopment in Adult Prairie Vole Offspring

Rogers, K.; Kiernan, E.; Partie, M.; Kenkel, W. M.

10.1101/2025.04.01.646614 — neuroscience — Posted on 2025-04-03

4693 Development of Replay-DMN Coordination Predicts Entorhinal Grid Codes

Pang, L.; Qu, Y.; Ou, J.; Wu, S.; Luo, Y.; Gohil, C.; Woolrich, M.; Behrens, T.; Liu, Y.

10.1101/2025.04.02.646732 — neuroscience — Posted on 2025-04-03

4694 Glycolysis-enhancing alpha 1-adrenergic antagonists are neuroprotective in Alzheimers disease

Zhang, Q.; Schultz, J.; Simmering, J.; Kirkpatrick, B. Q.; Weber, M. A.; Skuodas, S.; Hicks, T.; Pierce, G.; Laughlin, M.; Bertolli, A. X.; Larson, T.; Thangavel, R.; Oya, M.; Meyerholz, D.; Aldridge, G.; Fassler, J.; Narayanan, N. S.

10.1101/2025.04.03.647018 — neuroscience — Posted on 2025-04-03

4695 Active and predictive adjustment of pupil size for accommodating visual regularity

Jia, J.; Kong, Z.; Fang, F.

10.1101/2025.04.01.646516 — neuroscience — Posted on 2025-04-03

4696 Inferring global exponents in subsampled neural systems

Conte, D.; de Candia, A.

10.1101/2024.11.29.626005 — neuroscience — Posted on 2025-04-03

4697 Neural signatures of flexible temporal orienting under spatial and motor uncertainty

Gao, Y.; Echeverria-Altuna, I.; Boettcher, S. E. P.; Nobre, A. C.

10.1101/2025.04.03.646700 — neuroscience — Posted on 2025-04-03

4698 Listening to Your Own Brain Waves Sound Enhances Your Sleep Quality and Quantity

Aloulou, A.; Chauvineau, M.; Destexhe, A.; Leger, D.

10.1101/2025.03.31.646309 — neuroscience — Posted on 2025-04-03

4699 Three-dimensional Tracking Method for Water-Hopping Mudskippers in Natural Habitats

Choi, D.; Yung, K.; Bergerson, I.; Wallace, H.; Grafe, U.; Bhamla, S.

10.1101/2025.04.02.646728 — animal behavior and cognition — Posted on 2025-04-03

4700 Ability to predict irregular periods of food deprivation improves body-weight regulation and reduces weight gain in food-insecure starlings

Parker, C.; Nolan, R.; Andrews, C. P.; Bateson, M.

10.1101/2025.04.02.646744 — animal behavior and cognition — Posted on 2025-04-03

4701 Fly navigational responses to odor motion and gradient cues are tuned to plume statistics

Brudner, S.; Zhou, B.; Jayaram, V.; Santana, G. M.; Clark, D.; Emonet, T.

10.1101/2025.03.31.646361 — animal behavior and cognition — Posted on 2025-04-03

4702 Absence of reactive temporal response of baboons to the occurrence of predators

van Rooyen, N. T.; Thel, L.; Venter, J.; Fritz, H.; Prugnolle, F.; Rougeron, V.

10.1101/2025.04.01.646592 — animal behavior and cognition — Posted on 2025-04-03

4703 Canonical Wnt/β-catenin signalling regulates inducible aging and regeneration loss in hydra

Tökölyi, J.; Kumagai, Y.; Szilagyi, R. K.; Nagy, N. A.; Szakal, V.; Daryono, R. N. H.

10.1101/2025.04.01.646560 — developmental biology — Posted on 2025-04-03

4704 Optimizing Protocols for MicroRNA Profiling of Infant and Toddler Stool

Armstrong, D. A.; Soucy, S. M.; Muse, M. E.; Kolling, F. W.; Trask, H. W.; Howell, A. L.; Laue, H. E.; Hoen, A.; Gui, J.; Christensen, B.; Madan, J. C.; Karagas, M. R.; Howe, C. G.

10.1101/2025.04.01.646630 — developmental biology — Posted on 2025-04-03

4705 DEC1 Regulates Human β Cell Functional Maturation and Circadian Rhythm

Preza, S.; Zheng, B.; Liu, M.; Gao, Z.; Alvarez-Dominguez, J. R.; Biju, A.

10.1101/2025.04.03.647023 — developmental biology — Posted on 2025-04-03

4706 Nanosecond pulsed electric field precisely manipulates cytoplasmic Ca2+ oscillations during oocyte activation

Lu, Q.; Sun, Y.; An, T.; Liang, R.; Luo, Y.; Xia, H.; Fu, L.; Han, S.; Zhu, Y.; Song, Z.; Bai, X.; Fu, Y.; Fu, X.; Hou, Y.

10.1101/2025.04.03.646992 — developmental biology — Posted on 2025-04-03

4707 Cellular and molecular mechanism for reproductive capacity of male Mongolian cattle basing on single-cell sequencing for testis

Gao, S.; Fan, R.

10.1101/2025.04.01.646534 — developmental biology — Posted on 2025-04-03

4708 Intestinal control of feeding initiation in Drosophila melanogaster

Reinger, C.; Blackie, L.; Gillet, H.; Gaspar, P.; Medeiros, A. M.; Hadjieconomou, D.; Sickmann, M.; Affolter, M.; Miguel-Aliaga, I.; Kempf, A.; Müller, M.

10.1101/2025.03.31.646269 — developmental biology — Posted on 2025-04-03

4709 Behavioral Efficacy of AAV FOXG1 Gene Replacement Therapy in a Mouse Model of FOXG1 Syndrome

Torturo, C. L.; Du, A.; Kerker, K.; Gresack, J.; DeGrave, C.; Funk, K.; Agnihotri, P.; Hsieh, F.; Gunn, T. M.; Ramboz, S.; Bettencourt, B.; Reich, S.; Gao, G.; Wang, D.; Sah, D. W. Y.

10.1101/2025.04.02.646887 — neuroscience — Posted on 2025-04-03

4710 Single-Nucleus Transcriptomics Identifies Neuroblast Migration Programs Sensitive to Reelin and Cannabis in the Adolescent Nucleus Accumbens

Zuo, Y.; Formoli, N.; Libster, A.; Sun, D.; Turner, A.; Iemolo, A.; Telese, F.

10.1101/2025.04.03.646846 — neuroscience — Posted on 2025-04-03

4711 Non-canonical role for ATPase HSC70 in driving Clathrin remodeling during compensatory endocytosis in synapse

Krishnan, S.; Tsytsyura, Y.; Glyvuk, N.; Lehrich, J.; Klingauf, J.

10.1101/2025.04.02.646821 — neuroscience — Posted on 2025-04-03

4712 A neurocomputational basis of face recognition changes in ASD: E/I balance, internal noise, and weak neural representations

Wang, X.; Rios, E.; Chen, L.

10.1101/2025.04.02.646903 — neuroscience — Posted on 2025-04-03

4713 Neocortical Layer-5 tLTD Relies on Non-Ionotropic Presynaptic NMDA Receptor Signaling

Thomazeau, A.; Rannio, S.; Brock, J. A.; Wong, H. H.-W.; Sjöström, P. J.

10.1101/2025.02.07.637179 — neuroscience — Posted on 2025-04-03

4714 Characterization Eclosion Hormone Receptor function reveals differential hormonal control of ecdysis during Drosophila development.

Silva, V.; Scott, R.; Guajardo, P.; Luan, H.; Herzog, R.; White, B. H.; Ewer, J.

10.1101/2025.04.03.646974 — neuroscience — Posted on 2025-04-03

4715 Temporal adaptation aids object recognition in deep convolutional neural networks in suboptimal viewing scenario's

Brands, A. M.; Lange, G.; Groen, I. I. A.

10.1101/2025.04.03.646752 — neuroscience — Posted on 2025-04-03

4716 Large extracellular vesicles subsets and contents discrimination: the potential of morpho mechanical approaches at single EV level

Raizada, G.; Brunel, B.; Guillouzouic, J.; Le Ferrec, E.; Boireau, W.; Lesniewska, E.; Elie-Caille, C.

10.1101/2025.03.29.646084 — biophysics — Posted on 2025-04-03

4717 Mechanistic basis for non-exponential bacterial growth

Cylke, A.; Banerjee, S.

10.1101/2025.03.29.646116 — biophysics — Posted on 2025-04-03

4718 Pairwise Attention: Leveraging Mass Differences to Enhance De Novo Sequencing of Mass Spectra

Lapin, J.; Nilsson, A.; Wilhelm, M.; Käll, L.

10.1101/2025.03.28.645943 — bioinformatics — Posted on 2025-04-03

4719 Ancestral origin and structural characteristics of non-syntenic homologous chromosomes in abalones

Hirase, S.; Makino, T.; Takeuchi, T.; Kadota, M.; Kuraku, S.; Kikuchi, K.

10.1101/2025.04.02.641744 — genomics — Posted on 2025-04-03

4720 Complex interactions in the life cycle of a simple parasite shape the evolution of virulence

Silva, L. M.; Koella, J. C.

10.1101/2024.01.28.577571 — evolutionary biology — Posted on 2025-04-03

4721 Zebrafish armc9 mutant reveals a link between ARM-Type fold domain loss, inflammation, and spinal curvature

Rubilar-Fajardo, A.; Munoz-Montecinos, C.; Esperguel-Toledo, G.; Carrasco, S.; Castro, A.; Alvarado, P.; Kugath, A.; Araya-Secchi, R.; Allende, M.; Marcellini, S.; Gonzalez-Ortiz, M.; Roman, J.; Boltana, S.; Aguilera, F.; Cooper, T.; Cooper, J.; Cheng, K.; Mullins, M. C.; Caprile, T.; Fuentes, R.

10.1101/2025.04.02.646874 — developmental biology — Posted on 2025-04-03

4722 A human cytotrophoblast-villous endothelium-fetal organ multi-cell model and the impact on gene and protein expression in placenta cytotrophoblast, fetal hepatocytes and fetal kidney epithelial cells

Jones, H.; Wilson, R.

10.1101/2025.04.01.646643 — cell biology — Posted on 2025-04-03

4723 Goblet cells mechanically breach the epithelial barrier in gut homeostasis

Creff, J.; He, Y.; Bernat-Fabre, S.; Buscail, E.; Neuvendel, S.; Krishnakumar, V.; Mangeat, T.; Xue, S.-L.; Krndija, D.

10.1101/2025.04.01.646617 — cell biology — Posted on 2025-04-03

4724 Linear ubiquitination triggers Amph-mediated T-tubule biogenesis

Kawaguchi, K.; Hama, Y.; Yoshikawa, H.; Nishino, K.; Morimoto, K.; Nakamura, T.; Koizumi, M.; Sakamaki, Y.; Abe, K.; Kakuta, S.; Ichimura, K.; Ikeda, F.; Kosako, H.; Fujita, N.

10.1101/2025.04.03.646909 — cell biology — Posted on 2025-04-03

4725 A novel reporter to visualize and quantify endogenous inflammasomes and caspase-1 recruitment

Gohr, F. N.; Christensen, M. H.; Jenster, L.-M.; Tesfamariam, Y. M.; Lapp, D. J.; Mackenzie, J.; Schmidt, F. I.

10.1101/2025.03.30.646205 — immunology — Posted on 2025-04-03

4726 Sex, not estrous cycle stage, drives differences in the microglial transcriptome in the 5xFAD mouse model of amyloidosis

Rodriguez, L. C.; Noyes-Martel, N.; Becker, J. L.; Majewska, A. K.; O'Banion, K. M.

10.1101/2025.03.28.646050 — neuroscience — Posted on 2025-04-03

4727 A formal relation between two disparate mathematical algorithms is ascertained from biological circuit analyses

Liu, C.; Bowen, E. F.; Granger, R.

10.1101/2025.03.28.645962 — neuroscience — Posted on 2025-04-03

4728 Optimizing Artificial Neural Network Models to Predict Brain-Age from Functional MRI

Ogg, M.; Kitchell, L.

10.1101/2025.03.28.645964 — neuroscience — Posted on 2025-04-03

4729 Neuroimaging Biomarkers of Neuroprotection: Impact of Voluntary versus Enforced Exercise in Alzheimers Disease Models

Badea, A.; Mahzarnia, A.; Reddy, D.; Dong, Z.; Anderson, R. J.; Moon, H. S.; Stout, J. A.; Williams, J.; Hirschler, L.; Barbier, E. L.; Williams, C. L.

10.1101/2025.03.28.646015 — neuroscience — Posted on 2025-04-03

4730 Data-driven classification of tissue water populations by massively multidimensional diffusion-relaxation correlation MRI

Narvaez, O.; Yon, M.; Salo, R. A.; Kyyriäinen, J.; Estela, M.; Paasonen, E.; Topgaard, D.; Sierra, A.

10.1101/2025.03.28.645938 — neuroscience — Posted on 2025-04-03

4731 Modification and validation of a GAD-GFP mouse line without accelerated aging-related hearing loss.

Graves, K.; Ortgiesen, K.; Dai, W.; Llano, D. A.

10.1101/2025.03.29.646110 — neuroscience — Posted on 2025-04-03

4732 Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability

Garcia, J. D.; Wang, C.; Alexander, R.; Banks, E.; Fenton, T.; DeKeyser, J.-M.; Abramova, T. V.; George, A. L.; Ben-Shalom, R.; Hackos, D. H.; Bender, K. J.

10.1101/2024.12.17.629038 — neuroscience — Posted on 2025-04-03

4733 Natural language processing of gene descriptions for overrepresentation analysis with GeneTEA

Boyle, I. A.; Aquib, N. A.; Kocak, M.; Creasi, R.; Montgomery, P. G.; Campbell, C. D.; Dempster, J. M.

10.1101/2025.03.28.646026 — bioinformatics — Posted on 2025-04-03

4734 Development of a core genome multilocus sequence typing (cgMLST) scheme and life identification number (LIN) code classification system for Staphylococcus aureus

Hadjirin, N. F.; Yassine, I.; Bray, J. E.; Maiden, M. C. J.; Jolley, K. A.; Brueggemann, A. B.

10.1101/2025.03.29.646111 — genomics — Posted on 2025-04-03

4735 Neisseria gonorrhoeae LIN codes: a Robust, Multi-Resolution Lineage Nomenclature

Unitt, A.; Krisna, M. A.; Parfitt, K. M.; Jolley, K. A.; Maiden, M. C. J.; Harrison, O. B.

10.1101/2025.03.28.646058 — genomics — Posted on 2025-04-03

4736 Linking Aβ and tau in the amyloid cascade through the intersection of their proteostasis networks

Lim, C. M.; Hardy, J.; Vendruscolo, M.

10.1101/2025.03.28.646065 — neuroscience — Posted on 2025-04-03

4737 Sleep rescues age-associated loss of glial engulfment

Zhang, J.; Brown, E. B.; Lloyd, E.; Farhy-Tselnicker, I.; Keene, A. C.

10.1101/2025.04.02.646667 — neuroscience — Posted on 2025-04-03

4738 brain network dynamics during multi-task demands predict children math achievement

Cui, J.; Chen, R.; Zhao, Y.; Ding, R.; Tao, S.; Zhao, H.; Qin, S.

10.1101/2025.03.28.645841 — neuroscience — Posted on 2025-04-03

4739 Glucose levels are associated with mood, but the association is mediated by ratings of metabolic state

Kaduk, K.; Kaeber, M.; Kuehnel, A.; Berjano Torrado, M.; Grahlow, M.; Derntl, B.; Kroemer, N. B.

10.1101/2025.03.28.645871 — neuroscience — Posted on 2025-04-03

4740 BASELINE: A CRISPR Base Editing Platform for Mammalian-Scale Single-Cell Lineage Tracing

Winter, E.; Emiliani, F.; Cook, A.; Abderrahim, A.; McKenna, A. H.

10.1101/2025.03.19.644238 — synthetic biology — Posted on 2025-04-03

4741 T6SS-mediated competition by Stenotrophomonas rhizophila shapes seed-borne bacterial communities and seed-to-seedling transmission dynamics

Garin, T.; Brault, A.; Marais, C.; Briand, M.; Preveaux, A.; Bonneau, S.; Simonin, M.; Barret, M.; Sarniguet, A.

10.1101/2024.07.22.604635 — microbiology — Posted on 2025-04-03

4742 Transmembrane Serine Protease TMPRSS11B promotes an acidified tumor microenvironment and immune suppression in lung squamous cell carcinoma

Sunil, H. S.; Clemenceau, J.; Barnfather, I.; Nakkireddy, S. R.; Grichuk, A.; Izzo, L. T.; Evers, B. M.; Thomas, L.; Subramaniyan, I.; Li, L.; Putnam, W. T.; Zhu, J.; Updegraff, B.; Minna, J. D.; DeBerardinis, R. J.; Gao, J.; Hwang, T. H.; Oliver, T. G.; O'Donnell, K. A.

10.1101/2025.04.01.646727 — cancer biology — Posted on 2025-04-03

4743 Deep Mutational Scanning Reveals EGFR Mutations Conferring Resistance to the 4th-generation EGFR tyrosine kinase inhibitor BLU-945

Wang, Y.; Hao, Y.; Ranieri, M.; Hollenberg, M.; Lopez, A.; Moore, X. T. R.; Sherman, F.; Deng, J.; Wong, K.-K.; Shum, E.; Poirier, J.

10.1101/2025.03.31.646429 — cancer biology — Posted on 2025-04-03

4744 Epitope Expression Persists in Circulating Tumor Cells as Breast Cancers Acquire Resistance to Antibody Drug Conjugates

Mishra, A.; Abelman, R.; Cunneely, Q.; Putaturo, V.; Deshpande, A. A.; Bell, R.; Seider, E. M.; Xu, K. H.; Shan, M.; Kelly, J.; Huang, S.-B.; Gopinathan, K. A.; Kikkeri, K.; Edd, J. F.; Walsh, J.; Dai, C. S.; Ellisen, L.; Ting, D. T.; Nieman, L.; Toner, M.; Bardia, A.; Haber, D. A.; Maheswaran, S.

10.1101/2025.04.02.646822 — cancer biology — Posted on 2025-04-03

4745 Spatiotemporal organisation of residual disease in mouse and human BRCA1-deficient mammary tumours and breast cancer

Turos, D.; Decollogny, M.; Chanfon, A.; Siffert, M.; Romanens, L.; Tille, J.-C.; Tredan, O.; Labidi-Galy, I.; Valdeolivas, A.; Rottenberg, S.

10.1101/2025.04.02.646768 — cancer biology — Posted on 2025-04-03

4746 TarDis: Achieving Robust and Structured Disentanglement of Multiple Covariates

Inecik, K.; Kara, A.; Rose, A.; Haniffa, M.; Theis, F. J.

10.1101/2024.06.20.599903 — bioinformatics — Posted on 2025-04-03

4747 Neural correlates of perceptual decision making in primary somatosensory cortex

Armstrong, A.; Vlasov, Y.

10.1101/2025.03.29.646003 — neuroscience — Posted on 2025-04-03

4748 Pregnancy-Dependent Cardioprotection via GPER Activation in Dahl Salt-Sensitive Rats

Alencar, A. K. N.; Swan, K. F.; Manoharan, M. M.; Natale, C. A.; Lindsey, S. H.; Pridjian, G.; Garrett, M. R.; Bayer, C. L.

10.1101/2025.04.01.646468 — pharmacology and toxicology — Posted on 2025-04-03

4749 Reconfiguration of tumor cells with LCOR transcription factor mRNA nanotherapy to enhance immunotherapy efficacy

Serra-Mir, G.; Haro-Martiez, E.; Cannata, C.; Palomeque, J. A.; Blasco-Benito, S.; Lopez-Plana, A.; Sanz-Flores, M.; Sabartes, M.; Fornaguera, C.; Celia-Terrassa, T.

10.1101/2025.04.02.646434 — cancer biology — Posted on 2025-04-03

4750 Developing a zebrafish xenograft model of diffuse midline glioma

Wang, K.; Graziano, G.; Ceisel, A.; Xiao, H.; Banerjee, S.; Yu, Y.; Galanternik, M. V.; Weinstein, B. M.; Eberhart, C. G.; Mumm, J. S.; Raabe, E. H.

10.1101/2025.03.31.646163 — cancer biology — Posted on 2025-04-03

4751 Synthesis, anticancer properties, and biological profiling of synthetic glycan analogs of proscillaridin A

Somani, S.; Menta, L.; Wang-Johanning, F.; Johanning, G.; Hong, S.; Njoo, E.

10.1101/2025.03.31.646140 — cancer biology — Posted on 2025-04-03

4752 The glycosyltransferase ALG3 is an AKT substrate that regulates protein N-glycosylation

Navarro-Traxler, A. J.; Ghisolfi, L.; Lien, E. C.; Toker, A.

10.1101/2025.04.01.646556 — cancer biology — Posted on 2025-04-03

4753 EcDNA-borne PVT1 fusion stabilizes oncogenic mRNAs

Yi, H.; Zhang, S.; Swinderman, J.; Wang, Y.; Kanakaveti, V.; Hung, K. L.; Wong, I. T.-L.; Srinivasan, S.; Curtis, E. J.; Bhargava-Shah, A.; Li, R.; Jones, M. G.; Luebeck, J.; Zhao, Y.; Belk, J. A.; Kraft, K.; Shi, Q.; Yan, X.; Pritchard, S. K.; Liang, F. M.; Felsher, D. W.; Gilbert, L. A.; Bafna, V.; Mischel, P. S.; Chang, H.

10.1101/2025.04.01.646515 — cancer biology — Posted on 2025-04-03

4754 Enhanced FLI1 accessibility mediates STAG2-mutant leukemogenesis

Xu, J.; Scoca, V.; Chen, Y.; Zhan, Y. A.; Fisher, A.; Udoh, E.-o.; Fernando, S.; Alija, B.; Pantazi, J.; Sudunagunta, V.; Stewart, E.; Galang, A. M. D.; Williams, M.; Bhagat, G.; Gebhard, C.; Visconte, V.; Ondrejka, S.; Delwel, R.; Hu, M.; Koche, R. P.; Viny, A. D.

10.1101/2025.04.01.646632 — cancer biology — Posted on 2025-04-03

4755 Boosting Antitumour Efficacy and Immunity by Boron Neutron Capture Therapy with Size-Controlled Nanoparticles

Huang, W.; Kang, H. G.; Han, X.; Yu, J.; Chen, X.; Takata, T.; Sakurai, Y.; Suzuki, M.; Komatsu, N.

10.1101/2025.04.02.646946 — cancer biology — Posted on 2025-04-03

4756 Presence of Hepatitis B virus infection in colon cancer

Li, L.; Gong, W.; An, Y.; Tong, H.; Yang, M.; Wang, W.; Ma, L.; Tu, S.; Liu, Y.; duan, y.; Sun, K.

10.1101/2025.03.30.646256 — cancer biology — Posted on 2025-04-03

4757 Cysteine-Engineered CAR-T Cells to Counter Antigen Escape in B Cell Lymphoma

Luehle, J.; Krost, S.; Goerdeler, F.; Seitz, C.; Seeberger, P. H.; Moscovitz, O.

10.1101/2025.04.01.646520 — cancer biology — Posted on 2025-04-03

4758 Vitronectin binding affinity and cell viability effect of novel mechanotherapy drugs for neuroblastoma

Alaribe, S. C.; Granados-Aparici, S.; Oladipupo, A. R.; Vieco-Marti, I.; Titilayo, B. E.; Allen, G.; Noguera, R.

10.1101/2025.03.31.646300 — cancer biology — Posted on 2025-04-03

4759 Rare Subset of T Cells Form Heterotypic Clusters with Circulating Tumor Cells to Foster Cancer Metastasis

Scholten, D.; El-Shennawy, L.; Jia, Y.; Zhang, Y.; Hyun, E.; Reduzzi, C.; Hoffmann, A. D.; Almubarak, H. F.; Tong, F.; Dashzeveg, N. K.; Sun, Y.; Squires, J. R.; Lu, J.; Platanias, L. C.; Wasserfall, C. H.; Gradishar, W. J.; Cristofanilli, M.; Fang, D.; Liu, H.

10.1101/2025.04.01.646421 — cancer biology — Posted on 2025-04-03

4760 The Immune-Modulatory Function of Megakaryocytes in the Hematopoietic Niche of Myeloproliferative Neoplasms

Lee, S.; Yang, X.; Masarik, K.; Ahmed, T.; Zheng, L.; Zhan, H.

10.1101/2025.04.01.646152 — cancer biology — Posted on 2025-04-03

4761 Differential control of growth and identity by HNF4α isoforms in pancreatic ductal adenocarcinoma

Fang, P.; Wilson, E.; Stubben, C.; Kabir, A.; Affolter, K.; Zhang, X.; Snyder, E.

10.1101/2025.03.31.646428 — cancer biology — Posted on 2025-04-03

4762 Timing and clustering co-occurring genome amplifications incancers

Cocomello, S.; Santacatterina, G.; Bergamin, R.; Antonello, A.; Caravagna, G.

10.1101/2025.03.31.646456 — cancer biology — Posted on 2025-04-03

4763 The molecular chaperone TRAP1 promotes translation of Luc7l3 mRNA to enhance ovarian cancer cell proliferation

De Lella, S.; Pedalino, L.; Almagboul Abdalla Abaker, M.; Mignogna, C.; Cautiero, R.; Esposito, F.; Matassa, D. S.; Avolio, R.

10.1101/2025.04.01.646636 — cancer biology — Posted on 2025-04-03

4764 Single cell spatial transcriptomics identifies coordinated cellular programs that are associated with good prognosis in microsatellite stable colorectal cancer

Karlsen, V. T.; Majid, U.; Lindholm, H. T.; Umu, S. U.; Vander-Elst, K. R.; Beitnes, A.-C. R.; Merok, M. A.; Hagen, K. T.; Nilsen, H. R.; Yaqub, S.; Baekkevold, E. S.; Domanska, D.; Jahnsen, F. L.

10.1101/2025.03.31.646286 — cancer biology — Posted on 2025-04-03

4765 Optimizing miRNA-Based Breast Cancer Subtyping with AHALA: A Multi-Stage Classification Approach

Qaraad, M.; Rahrmann, E.; Guinovart, D.

10.1101/2025.04.03.646979 — cancer biology — Posted on 2025-04-03

4766 HDL Nanodiscs Loaded with Liver X Receptor Agonist Decreases Tumor Burden and Mediates Long-term Survival in Mouse Glioma Model

Halseth, T. A.; Mujeeb, A. A.; Liu, L.; Banerjee, K.; Lang, N.; Hollon, T.; Yu, M.; Roest, M. V.; Mei, L.; He, H.; Sheth, M.; Castro, M. G.; Schwendeman, A.

10.1101/2025.04.01.646644 — cancer biology — Posted on 2025-04-03

4767 DANEELpath: Open-source Digital analysis tools for histopathological research. Applications in NEuroblastoma modELs

Vieco-Marti, I.; Lopez-Carrasco, A.; Navarro, S.; Granados-Aparici, S.; Noguera, R.

10.1101/2025.03.31.646267 — cancer biology — Posted on 2025-04-03

4768 Entry and exit of Fragilariopsis cylindrus diatoms from the polar night: evidence for chromatin-mediated genome control

Joli, N.; Bourbousse, C.; Leduque, B.; Tirichine Delacour, L.; Laude, J.; Maumus, F.; Ait-Mohamed, O.; Klein, L.; Kusendo, B.; Concia, L.; Quadrana, L.; Barneche, F.; Babin, M.; Bowler, C.

10.1101/2025.04.02.646770 — genomics — Posted on 2025-04-03

4769 Mammal responses to habitat degradation induced by cashew expansion in West Africa

Na Mone, D.; Nhasse, I.; Soares, J.; Oliveira, R.; Lopes-Lima, M.; Palma, L.; Palmeirim, A. F.

10.1101/2025.03.29.646115 — ecology — Posted on 2025-04-03

4770 Genetic basis of cuticular hydrocarbon variation in the desert ant

Inbar, S.; Saied, B.; Cohen, P.; Frenkel, Z.; Pellen, Y.; Korol, A. B.; Privman, E.

10.1101/2025.03.30.646157 — ecology — Posted on 2025-04-03

4771 Thymidine kinase-independent click chemistry DNADetect™ probes as an EdU alternative for mammalian cell DNA labelling

Macdonald, J. R.; Fisher, G. M.; Braun, A.-S. C.; Thomas, S.; Skinner-Adams, T. S.; Hilko, D. H. H.; Poulsen, S.-A.; Andrews, K. T.

10.1101/2025.04.02.646904 — cell biology — Posted on 2025-04-03

4772 5-ethynyluridine perturbs nuclear RNA metabolism to promote the nuclear accumulation of TDP-43 and other RNA binding proteins

Hayes, L. R.; Zaepfel, B.; Duan, L.; Starner, A. C.; Bartels, M. D.; Rothacher, R. L.; Martin, S.; French, R.; Zhang, Z.; Sinha, I. R.; Ling, J. P.; Sun, S.; Ayala, Y. M.; Coller, J.; Van Nostrand, E. L.; Florea, L.; Kalab, P.

10.1101/2025.04.02.646885 — cell biology — Posted on 2025-04-03

4773 Deciphering the role of the lncRNA TRIBAL in hepatocyte models

Soubeyrand, S.; Lau, P.; McPherson, R.

10.1101/2025.04.02.646870 — cell biology — Posted on 2025-04-03

4774 Disrupted MOS signaling alters meiotic cell cycle regulation and the egg transcriptome

Cairo, G.; Kholod, O.; Palmer, O.; Goods, B. A.; Lacefield, S.

10.1101/2025.04.02.646881 — cell biology — Posted on 2025-04-03

4775 CDH-3/Cadherin, YAP-1/YAP and EGL-44/TEAD promote SYX-2/Syntaxin and EFF-1 fusogen-mediated phagosome closure

Ghose, P.; Whited, A.; Elkhlail, A.; Clark, G.

10.1101/2025.04.02.646655 — cell biology — Posted on 2025-04-03

4776 Long-term iododeoxyuridine labelling analysis finds no evidence of ovarian germline stem cell activity in adult or ageing mice

Onochie, C. M.; Alamri, A.; Kostanjevec, K.; Brown, A. F.; Burton, S. L.; Koigi, S. S.; Wattie, S. L.; Collinson, J. M.

10.1101/2025.04.01.646696 — cell biology — Posted on 2025-04-03

4777 Identification of Omaveloxolone as An Endoplasmic Reticulum Associated Degradation Inhibitor That Induces Early Apoptotic Signaling in Multiple Myeloma

Kropp, E. M.; Matono, S.; Wang, O. Y.; Bobida, A. M.; Kandarpa, M.; Grant, J. L.; Oleson, B. J.; Alt, A.; Talpaz, M.; Pianko, M.; Li, Q. M.

10.1101/2025.04.02.646787 — cell biology — Posted on 2025-04-03

4778 Adolescents with major depression featured by sensory-association subtyping show divergent information dynamics and streams

Liu, X.; Wan, B.; Zhang, X.; Liu, L.; Long, S.; Ge, R.; Cui, R.; Wen, X.; Yang, G.; Gao, Y.

10.1101/2025.03.29.646114 — neuroscience — Posted on 2025-04-03

4779 CtBP1 coordinates synaptic, metabolic and contractile changes induced by denervation in skeletal muscle

Cattaneo, O.; Lopez, G.; Rajendran, J.; Chabry, F.; Prola, A.; Liaudet, N.; Startchik, S.; Castets, P.

10.1101/2025.03.29.646097 — physiology — Posted on 2025-04-03

4780 Model-based tumour subclonal deconvolution accounting for spatio-temporal sampling biases

Rivaroli, E.; Buscaroli, E.; Milite, S.; Casagrande, A.; Caravagna, G.

10.1101/2025.03.31.646463 — cancer biology — Posted on 2025-04-03

4781 Discovery and therapeutic exploitation of Master Regulatory miRNAs in Glioblastoma

Abounader, R.; Saha, S.; Zhang, Y.; Gibert, M. K.; Dube, C.; Hanif, F.; Mulcahy, E.; Bednarek, S.; Marcinkiewicz, P.; Wang, X.; Kwak, G.; Hudson, K.; Sun, Y.; Dinda, M.; Saha, T.; Guessous, F.; Cruickshanks, N.; Colon, R. R.; Dell'Olio, L. G.; Anbu, R.; Kefas, B.; Kumar, P.; Klibanov, A. L.; Schiff, D.; Suk, J. S.; Hanes, J.; Mata, J.; Hafner, M.

10.1101/2025.04.01.646663 — cancer biology — Posted on 2025-04-03

4782 Single cell transcriptional evolution of myeloid leukaemia of Down syndrome

Trinh, M. K.; Schuschel, K.; Issa, H.; Thomas, R.; Parks, C.; Oszlanczi, A.; Ogbonnah, T.; Zhou, D.; Mamanova, L.; Prigmore, E.; Robertson, E.; Hodder, A.; Wenger, A.; Anderson, N. D.; Whitfield, H. J.; Treger, T. D.; Goncalves Dias, J.; Straathof, K.; O'Connor, D.; Young, M. D.; Jardine, L.; Adams, S.; Klusmann, J.-H.; Bartram, J.; Behjati, S.

10.1101/2025.04.01.646181 — cancer biology — Posted on 2025-04-03

4783 An LC-MS/MS method for the quantification of tobacco-specific carcinogen protein adducts.

Xing, C.; Freeman, B. N.

10.1101/2025.04.02.646861 — cancer biology — Posted on 2025-04-03

4784 Evidence of off-target probe binding in the 10x Genomics Xenium v1 Human Breast Gene Expression Panel compromises accuracy of spatial transcriptomic profiling

Hallinan, C.; Ji, H. J.; Salzberg, S. L.; Fan, J.

10.1101/2025.03.31.646342 — bioinformatics — Posted on 2025-04-03

4785 Accelerated Discovery of Cell Migration Regulators Using Label-Free Deep Learning-Based Automated Tracking

wu, p.-h.; Wirtz, D.; Chu, T.; lim, y.; Sun, Y.

10.1101/2025.04.01.646705 — cell biology — Posted on 2025-04-03

4786 Does the Brain's E:I Balance Really Shape Long-Range Temporal Correlations? Lessons Learned from 3T MRI

Sochan, L.; Archibald, J.; Weber, A.

10.1101/2025.03.28.645973 — neuroscience — Posted on 2025-04-03

4787 Accumbal Dopamine and Acetylcholine Dynamics during Psychostimulant Sensitization

Lange, G.; Gnazzo, F.; Beeler, J. A.

10.1101/2025.03.29.646091 — neuroscience — Posted on 2025-04-03

4788 Accelerated learning of a noninvasive human brain-computer interface via manifold geometry

Busch, E. L.; Fincke, E. C.; Lajoie, G.; Krishnaswamy, S.; Turk-Browne, N. B.

10.1101/2025.03.29.646109 — neuroscience — Posted on 2025-04-03

4789 Heterogeneity of human insular cortex: Five principles of functional organization across multiple cognitive domains

Cai, W.; Menon, V.

10.1101/2025.03.28.646039 — neuroscience — Posted on 2025-04-03

4790 The Organization of Serotonergic Fibers in the Pacific Angelshark Brain: Neuroanatomical and Supercomputing Analyses

Janusonis, S.; Metzler, R.; Vojta, T.

10.1101/2025.03.28.646017 — neuroscience — Posted on 2025-04-03

4791 Apusomonad rhodopsins, a new family of ultraviolet to blue light absorbing rhodopsin channels

Galindo, L. J.; Takaramoto, S.; Nagata, T.; Rozenberg, A.; Takahashi, H.; Beja, O.; Inoue, K.

10.1101/2025.04.02.646541 — biophysics — Posted on 2025-04-03

4792 The MAP2Ks can use ADP to phosphorylate and activate their substrate MAPKs in vitro

Juyoux, P.; von Velsen, J.; Pellegrini, E.; Bowler, M. W.

10.1101/2024.02.22.581546 — biochemistry — Posted on 2025-04-03

4793 Trypanosoma cruzi Has 32 Chromosomes: A Telomere-to-Telomere Assembly Defines Its Karyotype.

Greif, G.; Diaz-Viraque, F.; Chiribao, M. L.; Sanz-Rodriguez, C.; Robello, C.

10.1101/2025.03.27.645724 — genomics — Posted on 2025-04-03

4794 Strip cropping in organic agriculture results in 15% higher ground beetle richness and 30% higher activity density than monocultures

Croijmans, L.; Cuperus, F.; van Apeldoorn, D. F.; Bianchi, F. J. J. A.; Rossing, W. A. H.; Poelman, E.

10.1101/2024.11.02.621655 — ecology — Posted on 2025-04-03

4795 WITHDRAWN: DNA polymerase {lambda}-driven targeted mutagenesis fordirected evolution in human cells

Aiello, D.; Ciciani, M.; Marelli, F.; Stancampiano, M.; De Sanctis, V.; Bertorelli, R.; Kheir, E. G. A.; Maule, G.; Cereseto, A.; Arosio, D.

10.1101/2024.07.23.604813 — molecular biology — Posted on 2025-04-03

4796 Millisecond-Scale White Matter Dynamics Underlying Visuomotor Integration

Ueda, R.; Uda, H.; Hatano, K.; Sakakura, K.; Kuroda, N.; Kitazawa, Y.; Kanno, A.; Lee, M.-H.; Jeong, J.-W.; Luat, A. F.; ASANO, E.

10.1101/2025.03.28.646029 — neuroscience — Posted on 2025-04-03

4797 A Wildlife Health Outbreak Response Table-top Exercise for Pandemic Preparedness Planning

Ahyong, V.; Ayscue, P.; Gowen, R.; Spottiswoode, N.; Alex, C. E.; Anis, E.; Beiting, D. P.; Gibison, M.; Gordian-Rivera, E. I.; Greening, S.; Keatts, L.; Larsen, R. S.; Miller, E.; Niewinski, B.; Gagne, R. B.; Tato, C. M.; Ellis, J.; Murphy, L.

10.1101/2025.04.01.646690 — scientific communication and education — Posted on 2025-04-03

4798 Estimating the replicability of Brazilian biomedical science

10.1101/2025.04.02.645026 — scientific communication and education — Posted on 2025-04-03

4799 Trikafta rescues F508del-CFTR by tightening specific phosphorylation-dependent interdomain interactions

Wang, G.

10.1101/2024.11.20.624197 — biophysics — Posted on 2025-04-03

4800 LncMamba: A Deep Learning Model for lncRNA Localization Prediction Based on the Mamba Model

Huang, B.; Luo, Y.; Zhuang, Y.; He, S.; Yuan, C.

10.1101/2025.03.29.646080 — bioinformatics — Posted on 2025-04-03

4801 Nutritional state and predator exposure jointly mediate stress resilience and behavioural flexibility

Fischer, S.; Hirschenhauser, K.; Taborsky, B.; Fusani, L.; Canoine, V.; Tebbich, S.

10.1101/2025.04.02.646863 — animal behavior and cognition — Posted on 2025-04-03

4802 Wild jackdaws learn to tolerate juveniles to exploit new information

Arbon, J. J.; Truskanov, N.; Stott, E.; McIvor, G. E.; Thornton, A.

10.1101/2024.08.29.609864 — animal behavior and cognition — Posted on 2025-04-03

4803 Tracking butterfly flight in the field from an unmanned aerial vehicle (UAV): a methodological proof of principle.

de Margerie, E.; Monmasson, K.

10.1101/2024.07.17.603869 — animal behavior and cognition — Posted on 2025-04-03

4804 Improving interpretability of transcription factor binding models with DNA shape features

Keivanfar, R. L.; Yang, F.; Pollard, K. S.; Ioannidis, N. M.

10.1101/2025.04.01.646034 — genomics — Posted on 2025-04-03

4805 Bivariate genome-wide association study reveals polygenic contributions to covariance between total carotenoid and dry matter contents in yellow-fleshed cassava (Manihot esculenta)

Villwock, S. S.; Parkes, E. Y.; Nkouaya Mbanjo, E. G.; Rabbi, I.; Jannink, J.-L.

10.1101/2025.03.28.646041 — genetics — Posted on 2025-04-03

4806 Promotion of new expression of connexin gene Cx46 (GJA3) in the cochlea after Cx26 (GJB2) deficiency

Zhai, T.-Y.; Chen, J.; Kong, Y.; Liang, C.; Zhao, H.-B.

10.1101/2025.03.30.646179 — genetics — Posted on 2025-04-03

4807 A high-resolution genomic study of the Pama-Nyungan speaking Yolngu people of northeast Arnhem Land, Australia.

White, N.; Kumar, M.; Lambert, D.

10.1101/2025.04.03.646226 — genetics — Posted on 2025-04-03

4808 Human differentiated adipocytes can serve as surrogate mature adipocytes for adipocyte-derived extracellular vesicle analysis

Hade, M. D.; Butsch, B. L.; Palacio, P. L.; Nguyen, K. T.; Shantaram, D.; Noria, S.; Brethauer, S. A.; Needleman, B. J.; Hsueh, W.; Reategui, E.; Magana, S. M.

10.1101/2025.02.05.636729 — cell biology — Posted on 2025-04-03

4809 mclUMI: Markov clustering of unique molecular identifiers enables dynamic removal of PCR duplicates

Sun, J.; Li, S.; Canzar, S.; Cribbs, A. P.

10.1101/2025.03.15.643033 — molecular biology — Posted on 2025-04-03

4810 Surveillance of Japanese Encephalitis Virus in Piggery Effluent and Environmental Samples: A Complementary Tool for Outbreak Detection

Ahmed, W.; Gebrewold, M.; Williams, D. T.; Wang, J.; Smith, W.; Starick, L. G.; Fogarty, R. M.; Richards, K.; Simpson, S.

10.1101/2025.03.27.645166 — molecular biology — Posted on 2025-04-03

4811 H3K27 and H3K9 Methylation Mask Potential CTCF Binding Sites to Maintain 3D Genome Integrity

Fukuda, K.; Shinkai, Y.; Shimura, C.

10.1101/2025.04.02.646724 — molecular biology — Posted on 2025-04-03

4812 Eomesodermin defines uterine NK cells crucial for pregnancy success in mice

Barahona, J. D.; Yang, L.; Yokoyama, W. M.

10.1101/2025.03.29.645626 — immunology — Posted on 2025-04-03

4813 White Matter Hyperintensities Precede other Biomarkers in GRN Frontotemporal Dementia

Soltaninejad, M.; Dadar, M.; Collins, D. L.; Rajabli, R.; Venkatraghavan, V.; Bouzigues, A.; Russell, L. L.; Foster, P. H.; Ferry-Bolder, E.; van Swieten, J. C.; Jiskoot, L. C.; Seelaar, H.; Sanchez-Valle, R.; Laforce, R.; Graff, C.; Galimberti, D.; Vandenberghe, R.; de Mendonca, A.; Tiraboschi, P.; Santana, I.; Gerhard, A.; Levin, J.; Nacmias, B.; Otto, M.; Bertoux, M.; Lebouvier, T.; Butler, C. R.; Le Ber, I.; Finger, E.; Tartaglia, M. C.; Masellis, M.; Rowe, J. B.; Synofzik, M.; Moreno, F.; Borroni, B.; Rohrer, J. D.; Iturria-Medina, Y.; Ducharme, S.

10.1101/2025.03.31.646450 — neuroscience — Posted on 2025-04-03

4814 Neural entrainment to pitch changes of auditory targets in noise

Guo, X.; Mai, G.; Mohammadi, Y.; Benzaquen, E.; Yukhnovich, E.; Sedley, W.; Griffiths, T. D.

10.1101/2025.04.03.646585 — neuroscience — Posted on 2025-04-03

4815 GPR34 regulates microglia state and loss-of-function rescues TREM2 metabolic dysfunction

Raju, K.; Joy, D.; Guldberg, S. M.; Germain, K.; Gould, N.; Ha, C.; Tatarakis, D.; Dugas, J. C.; Davis, S.; Reeves, A.; Andrews, S. V.; Weerakkody, T.; Suh, J.; Lunkes de Melo, G.; Xiong, K.; Lightfoot, Y.; Propson, N.; Sandmann, T.; Di Paolo, G.; Lewcock, J. W.; Ray, W. J.; Monroe, K.

10.1101/2025.03.28.646038 — neuroscience — Posted on 2025-04-03

4816 Excitatory synaptic transmission is differentially modulated by opioid receptors along the claustro-cingulate pathway

Reeves, J. M.; Arias-Hervert, E. R.; Kmiec, G. E.; Birdsong, W. T.

10.1101/2025.03.31.646444 — neuroscience — Posted on 2025-04-03

4817 Cortical motor activity modulates respiration and reduces apnoea in neonates

Zandvoort, C. S.; Usman, F.; Robinson, S.; Fatunla, O.; Adams, E.; Pattinson, K. T. S.; Farmer, S. F.; Hartley, C.

10.1101/2025.04.03.646882 — neuroscience — Posted on 2025-04-03

4818 Male obesity causes adipose mitochondrial dysfunction in F1 progeny via a let-7-DICER axis.

Huang, C.; Park, J.-H.; Altintas, A.; Stanic, N.; de Leon, K. K.; Isacson, S.; Kalogeropoulos, P.; Batarlar, H. T.; Malmros, R. V.; Havelund, J.; Marcher Larsen, B. D.; Chien, Y.-T.; Huang, W.-C.; Szczepanowska, K.; Lackmann, J.-W.; Trifunovic, A.; Hejbol, E. K.; Detlefsen, S.; Jepsen, I. E.; Kolstrup, S. H.; Laguna Barraza, R. A.; Gonzalez, J.-M.; Khodosevich, K.; Faergeman, N. J.; Mori, M. A.; Friedländer, M. R.; Oest, A.; Barres, R.; Kornfeld, J.-W.

10.1101/2024.10.03.615866 — physiology — Posted on 2025-04-03

4819 Caveolin assemblies displace one bilayer leaflet to organize and bend membranes

Doktorova, M.; Daum, S.; Reagle, T. R.; Cannon, H. I.; Ebenhan, J.; Neudorf, S.; Han, B.; Sharma, S.; Kasson, P.; Levental, K.; Bacia, K.; Kenworthy, A. K.; Levental, I.

10.1101/2024.08.28.610209 — biophysics — Posted on 2025-04-03

4820 Differential T cell receptor gene expression analysis using the Wilcoxon test with similarity-based weighting

Buytenhuijs, F.; Ankan, A.; Textor, J.

10.1101/2025.03.28.645951 — bioinformatics — Posted on 2025-04-03

4821 The Self-Interest of Adolescents Overrules Cooperation in Social Dilemmas

Wu, X.; Fu, H.; Aydogan, G.; Feng, C.; Qin, S.; Liu, C.

10.1101/2020.10.26.354704 — animal behavior and cognition — Posted on 2025-04-03

4822 Expression spectrum of TE-derived transcripts in human adult tissues

Miao, B.; Zhang, B.; WU, T. P.; Luo, X.; Ademovic, A.; Yang, Y.

10.1101/2025.03.29.646092 — genomics — Posted on 2025-04-03

4823 A novel supergene controls queen size and colony social organization in the ant Myrmica ruginodis

Sigeman, H.; Seppä, P.; Downing, P. A.; Webster, M. T.; Helanterä, H.; Viljakainen, L.

10.1101/2025.03.24.644106 — evolutionary biology — Posted on 2025-04-03

4824 Dinucleotide preferences underlie apparent codon preference reversals in the Drosophila melanogaster lineage

Yamashita, H.; Matsumoto, T.; Kawashima, K.; Daanaa, H. S. A.; Yang, Z.; Akashi, H.

10.1101/2024.10.10.617326 — evolutionary biology — Posted on 2025-04-03

4825 Actomyosin forces trigger a conformational change in desmoplakin within desmosomes.

Dong, Y.; Elgerbi, A.; Xie, B.; Choy, J. S.; Sivasankar, S.

10.1101/2024.11.19.624364 — cell biology — Posted on 2025-04-03

4826 UMIche: A platform for robust UMI-centric simulation and analysis in bulk and single-cell sequencing

Sun, J.; Li, S.; Canzar, S.; Cribbs, A. P.

10.1101/2025.03.15.643072 — molecular biology — Posted on 2025-04-03

4827 Tresor: An integrated platform for simulating transcriptomic reads with realistic PCR error representation across various RNA sequencing technologies

Sun, J.; Cribbs, A. P.

10.1101/2025.03.15.643015 — molecular biology — Posted on 2025-04-03

4828 Lower Aperiodic EEG Activity is Associated with Reduced Verbal Fluency Performance Across Adulthood

McKeown, D. J.; Roberts, E.; Finley, A. J.; Kelley, N. J.; Keage, H. A. D.; Schinazi, V. R.; Baumann, O.; Moustafa, A. A.; Angus, D. J.

10.1101/2024.08.13.607827 — neuroscience — Posted on 2025-04-03

4829 A Kv2 inhibitor combination reveals native neuronal conductances consistent with Kv2/KvS heteromers

Stewart, R. G.; Marquis, M. J.; Jo, S.; Harris, B.; Aberra, A.; Cook, V.; Whiddon, Z.; Yarov-Yarovoy, V.; Ferns, M.; Sack, J. T.

10.1101/2024.01.31.578214 — neuroscience — Posted on 2025-04-03

4830 Molecular Crowding Suppresses Mechanical Stress-Driven DNA Strand Separation

Desai, P. R.; Marko, J. F.

10.1101/2024.12.11.628023 — biophysics — Posted on 2025-04-03

4831 Quantifying acyl chain interdigitation in simulated bilayers via direct transbilayer interactions

Chaisson, E. H.; Heberle, F. A.; Doktorova, M.

10.1101/2024.12.20.629658 — biophysics — Posted on 2025-04-03

4832 BioPKS Pipeline: An integrated platform for merging the computational design of chimeric type I polyketide synthases with enzymatic pathways for chemical biosynthesis

Chainani, Y.; Diaz, J.; Guilarte-Silva, M.; Blay, V.; Zhang, Q.; Sprauge, W.; Tyo, K.; Broadbelt, L. J.; Mukhopadhyay, A.; Keasling, J. D.; Martin, H. G.; Backman, T. W. H.

10.1101/2024.11.04.621673 — bioinformatics — Posted on 2025-04-03

4833 Sensory responsivity and its connection to sympathetic activation and deactivation: implications for stress and learning

Flo, E. E.

10.1101/2025.04.01.646564 — neuroscience — Posted on 2025-04-03

4834 Overcoming myeloid-driven resistance to CAR T therapy by targeting SPP1

Gholamin, S.; Natri, H. M.; Zhao, Y.; Xu, S.; Aftabizadeh, M.; Comin-Anduix, B.; Saravanakumar, S.; Masia, C.; Wong, R. A.; Peter, L.; Chung, M.-i.; Mee, E. D.; Aguilar, B.; Starr, R.; Torrejon, D. Y.; Alizadeh, D.; Wu, X.; Kalbasi, A.; Ribas, A.; Forman, S.; Badie, B.; Banovich, N.; Brown, C.

10.1101/2025.04.01.646202 — cancer biology — Posted on 2025-04-03

4835 Sketch, capture and layout phylogenies

Huson, D.

10.1101/2025.04.01.646633 — bioinformatics — Posted on 2025-04-03

4836 Green cities and the risk for vector-borne disease transmission for humans and animals: a scoping review

10.1101/2025.04.01.646559 — ecology — Posted on 2025-04-03

4837 Aging reduces excitatory bandwidth, alters spectral tuning curve diversity, and reduces sideband inhibition in L2/3 of primary auditory cortex

Maximov, K.; O. Kanold, P.

10.1101/2025.04.02.646797 — neuroscience — Posted on 2025-04-03

4838 The extended language network: Language selective brain areas whose contributions to language remain to be discovered

Wolna, A.; Wright, A.; Lipkin, B.; Fedorenko, E.

10.1101/2025.04.02.646835 — neuroscience — Posted on 2025-04-03

4839 Neural Tracking of the Maternal Voice in the Infant Brain

Jessen, S.; Orf, M.; Obleser, J.

10.1101/2025.04.01.646597 — neuroscience — Posted on 2025-04-03

4840 Mapping the coupling between tract reachability and cortical geometry of the human brain

Li, D.; Zalesky, A.; Wang, Y.; Wang, H.; Ma, L.; Cheng, L.; Banaschewski, T.; Barker, G. J.; Bokde, A. L.; Brühl, R.; Desrivieres, S.; Flor, H.; Garavan, H.; Gowland, P. A.; Grigis, A. A.; Heinz, A.; LEMAITRE, H.; Martinot, J.-L.; Martinot, M.-L. P.; Artiges, E.; Nees, F.; Orfanos, D. P.; Poustka, L.; Smolka, M. N.; Vaidya, N.; Walter, H.; Whelan, R.; Schumann, G.; Jia, T.; Chu, C.; Fan, L.

10.1101/2025.03.31.646498 — neuroscience — Posted on 2025-04-03

4841 Tracing the Shared Foundations of Gene Expression and Chromatin Structure

Liang, H.; Berger, B.; Singh, R.

10.1101/2025.03.31.646349 — bioinformatics — Posted on 2025-04-02

4842 CREsted: modeling genomic and synthetic cell type-specific enhancers across tissues and species

Kempynck, N.; De Winter, S.; Blaauw, C. H.; Konstantakos, V.; Dieltiens, S.; Eksi, E. C.; Bercier, V.; Taskiran, I. I.; Hulselmans, G.; Spanier, K.; Christiaens, V.; Van Den Bosch, L.; Mahieu, L.; Aerts, S.

10.1101/2025.04.02.646812 — genomics — Posted on 2025-04-03

4843 Characterization of the intraspecies chimeric mouse brain at embryonic day 12.5

Strell, P.; Waldron, M. A.; Johnson, S.; Shetty, A. V.; Crane, A.; Steer, C.; Low, W. C.

10.1101/2025.03.31.646380 — developmental biology — Posted on 2025-04-02

4844 CHD7 binds distinct regions in the Sox11 locus to regulate neuronal differentiation

Martinez, E.; Jadali, A.; Qiu, J.; Hinman, A. M.; Ni, J. Z.; Kim, J.; Kwan, K. Y.

10.1101/2025.04.02.646816 — molecular biology — Posted on 2025-04-03

4845 APOE genotype-dependent differences in human astrocytic energy metabolism

Budny, V.; Bodenmann, C.; Zuercher, K. J.; de Leeuw, S. M.; Weber, R. Z.; Ravotto, L.; Ruminot, I.; Barros, L. F.; Weber, B.; Tackenberg, C.

10.1101/2025.03.31.646283 — neuroscience — Posted on 2025-04-02

4846 Non-linear and time-domain sleep qEEG features predict CSF protein damage markers in early Alzheimers disease

Gaeta, A. M.; Vinaras, L. G.; Barbe, F.; Olmos, P. M.; Pamplona, R.; Dakterzada, F.; Munoz-Barrutia, A.; Pinol-Ripoll, G.

10.1101/2025.03.28.645905 — neuroscience — Posted on 2025-04-02

4847 Common and distinct neural mechanisms of aversive and appetitive pain-related learning

Li, J.; Schmidt, K.; Busch, L.; Forkmann, K.; Spisak, T.; Kaur, J.; Schlitt-Nguyen, F.; Wiech, K.; Bingel, U.

10.1101/2025.04.02.646781 — neuroscience — Posted on 2025-04-03

4848 Investigating the role of conformational heterogeneity in FUS-RRM fibrillation

Aazmi, O.; Aswale, A. R.; Saju, L.; Chugh, J.

10.1101/2025.03.28.646059 — biophysics — Posted on 2025-04-02

4849 Comprehensive Analysis of CRISPR Array Repeat Mutations Reveals Subtype-Specific Patterns and Links to Spacer Dynamics

Mitrofanov, A.; Beisel, C.; Baumdicker, F.; Alkhnbashi, O.; Backofen, R.

10.1101/2025.04.02.646798 — bioinformatics — Posted on 2025-04-02

4850 Strengthening Antisense Oligonucleotide-Mediated Anti-Tumor Immunity via Metal-Organic Framework Nanoparticles

Nowak, J. A.; Cho, E.; Davis, M. A.; Zheng, S.; Bell, L.; Sha, F.; Magdalenski, J. S.; Farha, O. K.; Teplensky, M. H.

10.1101/2025.03.28.645811 — bioengineering — Posted on 2025-04-02

4851 Probing the mechanism of peptidoglycan amidase activation by FtsEX-EnvC

Cook, J.; Crow, A.

10.1101/2025.04.02.646785 — biochemistry — Posted on 2025-04-02

4852 The photoreaction process of a large-Stokes-shift red fluorescence protein-LSSmCherry1

Li, G.; Meng, J.; Bai, X.; Zhao, S.; Hu, Y.; Dai, J.; Song, Y.; Peng, X.; Zhao, Q.

10.1101/2025.04.01.646287 — biochemistry — Posted on 2025-04-02

4853 Genome-replicating HC-AdV, a novel high-capacity adenoviral vector class featuring enhanced in situ payload expression

Kolibius, J.; Weiss, F.; Freitag, P. C.; Plueckthun, A.

10.1101/2025.04.02.646678 — biochemistry — Posted on 2025-04-02

4854 Beyond genetic indicators: how reproductive mode and hybridization challenge freshwater mussel conservation

Faust, E.; Conrads, J.; Giulio, M.; Ciofi, C.; Natali, C.; Feulner, P. G.; Weber, A. A.-T.

10.1101/2025.03.28.645956 — genomics — Posted on 2025-04-02

4855 A Bayesian approach to include Indigenous Knowledge in habitat selection functions

Gryba, R.; Von Duyke, A. L.; Huntington, H. P.; Adams, B.; Frantz, B.; Gatten, J.; Harcharek, Q.; Sarren, R.; Henry, G. H.; Auger-Methe, M.

10.1101/2025.03.26.645387 — ecology — Posted on 2025-04-02

4856 An adult clock regulator links circadian rhythms to pancreatic β-cell maturation

Montalvo, A. P.; Gao, Z.; Liu, M.; Gruskin, Z. L.; Leduc, A.; Preza, S.; Xie, Y.; Rozo, A. V.; Ahn, J. H.; Straubhaar, J. R.; Doliba, N.; Stoffers, D.; Slavov, N.; Alvarez-Dominguez, J. R.

10.1101/2023.08.11.552890 — cell biology — Posted on 2025-04-02

4857 Interleukin-13-mediated alterations in esophageal epithelial mitochondria contribute to tissue remodeling in eosinophilic esophagitis

Jackson, J. L.; Saxena, R.; Murray, M. G.; Staub, A. J.; Klochkova, A.; Bordner, T. H.; Worrell, C.; Fuller, A. D.; Crespo, J. M.; Klein-Szanto, A. J.; Elrod, J.; Karakasheva, T. A.; Ruffner, M.; Muir, A. B.; Whelan, K. A.

10.1101/2025.04.02.646853 — molecular biology — Posted on 2025-04-02

4858 Genetic diversity of pangolin coronaviruses reveals a key immuno-evasive substitution at spike residue 519

Yo, M. S.; Kaku, Y.; Kosugi, Y.; Tolentino, J. E.; Cao, y. R.; Sato, K.

10.1101/2025.04.01.646621 — microbiology — Posted on 2025-04-02

4859 The aPBP-type cell wall synthase PBP1b plays a specialized role in fortifying the Escherichia coli division site against osmotic rupture

Navarro, P. P.; Vettiger, A.; Hajdu, R.; Ananda, V. Y.; Lopez-Tavares, A.; Schmid, E.; Walter, J.; Loose, M.; Chao, L. H.; Bernhardt, T. G.

10.1101/2025.04.02.646830 — microbiology — Posted on 2025-04-02

4860 Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability

Garcia, J. D.; Wang, C.; Alexander, R.; Banks, E.; Fenton, T.; DeKeyser, J.-M.; Abramova, T. V.; George, A. L.; Ben-Shalom, R.; Hackos, D. H.; Bender, K. J.

10.1101/2024.12.17.629038 — neuroscience — Posted on 2025-04-02

4861 Metabolic task analysis reveals distinct metabotypes in end-stage dilated cardiomyopathy

Nihant, B.; Verdonschot, J.; Balan, S.; Thielecke, E.; Luiken, J.; Nabben, M.; Heymans, S.; Breuer, M.; Adriaens, M.

10.1101/2025.03.28.645901 — systems biology — Posted on 2025-04-02

4862 Combining functional annotation and multi-trait fine-mapping methods improves fine-mapping resolution at glycaemic trait loci

Soenksen, J.; Chen, J.; Varshney, A.; Martin, S.; MAGIC, ; Parker, S. C. J.; Morris, A. P.; Asimit, J. L.; Barroso, I.

10.1101/2024.11.13.623384 — genetics — Posted on 2025-04-02

4863 EcoFoldDB: Protein structure-guided functional profiling of ecologically relevant microbial traits at the metagenome scale

Ghaly, T. M.; Rajabal, V.; Russell, D.; Colombi, E.; Tetu, S. G.

10.1101/2025.04.02.646905 — microbiology — Posted on 2025-04-02

4864 Bidirectional Modulation of Somatostatin-expressing Interneurons in the Basolateral Amygdala Reduces Neuropathic Pain Perception in Mice

Apte, A.; Fernald, J.; Slater, C.; Sorrentino, M.; Youngerman, B.; Wang, Q.

10.1101/2025.03.28.645947 — neuroscience — Posted on 2025-04-02

4865 Genetic risk in endolysosomal network genes correlates with endolysosomal dysfunction across neural cell types in Alzheimer's disease

10.1101/2025.03.16.643481 — neuroscience — Posted on 2025-04-02

4866 Assistive sensory-motor perturbations influence learned neural representations

Rajeswaran, P.; Payeur, A.; Lajoie, G.; Orsborn, A. L.

10.1101/2024.03.20.585972 — neuroscience — Posted on 2025-04-02

4867 Intrinsic dynamic shapes responses to external stimulation in the human brain

Nentwich, M.; Leszczynski, M.; Schroeder, C. E.; Bickel, S.; Parra, L. C.

10.1101/2024.08.05.606665 — neuroscience — Posted on 2025-04-02

4868 A systems biology investigation to identify potential bi-omarkers in leprosy-affected host cells.

Chowdhury, S.; Ansari, A.; Verma, P.; Mavlankar, A.; Tripathi, A.; Pena, M.; Sharma, R.; Caskey, J.; Truman, R.; Singh, P.

10.1101/2025.03.28.646010 — systems biology — Posted on 2025-04-02

4869 Modelling the influence of rhizodeposits on root water uptake

Mair, A.; Gomez Peral, E.; Ptashnyk, M.; Dupuy, L. X.

10.1101/2025.03.28.645940 — systems biology — Posted on 2025-04-02

4870 Single-chain permuted proteins for dimerization-based control of protein activity and cellular processes

Zeleznik Ramuta, T.; Snoj, J.; Kos, T.; Ljubetic, A.; Hafner-Bratkovic, I.; Jerala, R.

10.1101/2025.03.31.645681 — synthetic biology — Posted on 2025-04-02

4871 Investigating the Impact of Measurement Variance on Gene Circuit Model Parameterization

Spartalis, T. R.; Tang, W.; Tang, X.

10.1101/2025.04.02.646175 — synthetic biology — Posted on 2025-04-02

4872 Chemically Synthesized Ultra-long DNA as Building Blocks to Accelerate Complex Gene Construction in Synthetic Biology

Zhang, M.; Hu, Y.; Huang, H.; Shi, Y.

10.1101/2025.04.02.646740 — synthetic biology — Posted on 2025-04-02

4873 Relationship between melanoma vemurafenib tolerance thresholds and metabolic pathway choice and Wnt signaling involvement

Nangia-Makker, P.; Ahrens, M.; Purandare, N.; Aras, S.; Li, J.; Gurdziel, K.; Jang, H.; Kim, S.; Shekhar, M. P.

10.1101/2025.03.06.641924 — cancer biology — Posted on 2025-04-02

4874 Supervised learning of protein variant effects across large-scale mutagenesis datasets

Schulze, T. K.; Blaabjerg, L. M.; Cagiada, M.; Lindorff-Larsen, K.

10.1101/2025.04.02.646878 — biophysics — Posted on 2025-04-02

4875 Allo-PED: Leveraging protein language models and structure features for allosteric site prediction

Chen, X.; Zheng, J.; Huang, Z.; Xu, Z.; Huang, J.; Wei, Y.; Zhang, H.

10.1101/2025.03.28.645953 — bioinformatics — Posted on 2025-04-02

4876 Development of a Vibrio natriegens-based plate-clearing assay for rapid screening of PET-hydrolyzing enzymes

Bolstad, I. M.; Trooyen, S. H.; Luciano, D.; Petersen, E.; Courtade, G.

10.1101/2025.04.02.646774 — biochemistry — Posted on 2025-04-02

4877 Baseline bioenergetic profile of mitochondria and permeabilized tissue of Aedes aegypti (Diptera: Culicidae) throughout its life cycle

Castillo-Morales, R. M.; Urbina-Duitama, D. L.; Mendez, S. C.; Duque, J. E.

10.1101/2025.04.02.646709 — biochemistry — Posted on 2025-04-02

4878 Efficient Design of Affilin(R) Protein Binders for HER3

Diaz-Rovira, A. M.; Lotze, J.; Hoffmann, G.; Pallara, C.; Molina, A.; Coburger, I.; Gloser-Bräunig, M.; Meysing, M.; Zwarg, M.; Diaz, L.; Guallar, V.; Bosse-Doenecke, E.; Roda, S.

10.1101/2025.04.02.646551 — biochemistry — Posted on 2025-04-02

4879 Specific binding modes of SIRT6 C-terminal domain to the nucleosome core particle influence DNA unwrapping and H3K27 accessibility

Qiu, Y.; Papai, G.; Ben Shem, A.; Bignon, E.

10.1101/2025.04.02.646764 — biochemistry — Posted on 2025-04-02

4880 Theory on the accurate estimation of Michaelis-Menten enzyme kinetic parameters from steady state and progress curve datasets

Murugan, R.

10.1101/2025.04.02.646753 — biochemistry — Posted on 2025-04-02

4881 Single-cell analysis of the epigenome and 3D chromatin architecture in the human retina

Yuan, Y.; Biswas, P.; Zemke, N.; Dang, K.; Wu, Y.; D Antonio, M.; Xie, Y.; Yang, Q.; Dong, K.; Lau, P. K.; Li, D.; Seng, C.; Bartosik, W.; Buchanan, J.; Lin, L.; Lancione, R.; Wang, K.; Lee, S.; Gibbs, Z.; Ecker, J.; Frazer, K.; Wang, T.; Preissl, S.; Wang, A.; Ayyagari, R.; Ren, B.

10.1101/2024.12.28.630634 — genomics — Posted on 2025-04-02

4882 Pre-Clinical Evaluation of a Novel Immunomodulator: a potential immunotherapy for coronaviral disease

Lee, I.; Desai, A.; Berdis, A. J.; Patil, A.; Xu, Y.; Pozza-Adams, K.

10.1101/2025.04.01.646433 — cell biology — Posted on 2025-04-02

4883 AquIRE reveals multiple mechanisms of clinically induced RNA damage and the conservation and dynamics of glycoRNAs

Zhang, Z.; Kotopanova, Z. V.; Dang, K.; Kong, X.; Simms, N.; Yuen, T. W.; Sonmez, A.; Beadle, L. F.; Hilton, E.; Qureshi, T.; Coppola, M.; Holmes, C. D.; Kan, K. T.; Ashe, M.; Gallois, P.; Ashe, H.; Lafontaine, D. L.; Braun, M.; Saunders, M.; Sutton, P.; Thornton, D.; Knight, J. R.

10.1101/2025.04.01.646554 — molecular biology — Posted on 2025-04-02

4884 Effect of Azithromycin treatment on the microbial composition, functional dynamics and resistomes of endocervical, vaginal and rectal microbiomes of women in Fiji with Chlamydia trachomatis infection

Bommana, S.; Olagoke, S.; Hu, Y.; Wang, R.; Kama, M.; Dehdashti, M.; Kodimerla, R.; Read, T.; Dean, D.

10.1101/2025.04.02.646699 — microbiology — Posted on 2025-04-02

4885 Phage Steering in the Presence of a Competing Bacterial Pathogen

Czerwinski, S. M.; Gurney, J.

10.1101/2024.09.28.615603 — microbiology — Posted on 2025-04-02

4886 A Milk Fat Globule Membrane-enriched dairy co-product modulates gut Faecalibaculum rodentium metabolism in association with the prevention of cognitive impairment in aging male Wistar rats

Schalich, K.; Kim, Y.-T.; Sylvestre, D.; Kalanetra, K.; Barile, D.; Taha, A. Y.; Mills, D. A.

10.1101/2025.04.02.646113 — microbiology — Posted on 2025-04-02

4887 Enhancing DNA recovery in low-biomass snow algae samples: a comparative study of extraction methods and their effect on community composition

Almela, P.; Hamilton, T. L.

10.1101/2025.04.02.646824 — microbiology — Posted on 2025-04-02

4888 Parkinson's Paradox: Alpha-synuclein's Selective Strike on SNc Dopamine Neurons over VTA

Phan, L.; Miller, D.; Gopinath, A.; Gunther, D.; Kiel, K.; Quintin, S.; Borg, D.; Hasanpour-Segherlou, Z.; Newman, A.; Sorrentino, Z.; Miller, E.; Seibold, J.; Hoh, B.; Giasson, B.; Khoshbouei, H.

10.1101/2025.03.24.644952 — neuroscience — Posted on 2025-04-02

4889 A mutation in the transmembrane domain of Adenylate cyclase 3 impairs enzymatic function to cause sex-specific depression- and anxiety-like behaviors and food seeking in a rat model

Fitzpatrick, M. K.; Dyson, C.; Beeson, A.; Adrian, L.; Marrs, G.; Grzybowski, M.; Klotz, J.; Geurts, A. M.; Chen, R.; Weiner, J. L.; Woods, L. C. S.

10.1101/2025.03.28.645767 — neuroscience — Posted on 2025-04-02

4890 Principles underlying implementation of nearly-homeostatic biological networks

Tang, Z. F.; McMillen, D. R.

10.1101/2025.04.02.646789 — synthetic biology — Posted on 2025-04-02

4891 The third alpha helix of plant homeoproteins are generally cell-penetrating to plant cells

Squire, H. J.; Wang, J. W.-T.; Landry, M. P.

10.1101/2025.04.01.646723 — plant biology — Posted on 2025-04-02

4892 Site-resolved energetic information from HX/MS experiments

Lu, C.; Wells, M. L.; Reckers, A.; Glasgow, A.

10.1101/2024.08.04.606547 — biophysics — Posted on 2025-04-02

4893 Rapid optimization of protein function in mammalian cells via microbe-independent deep assembly and screening

Wu, Y.; Wang, P.; Liu, L. X.; Gao, C.; Qin, Q.; Hageman, M.; Kirkland, T. A.; Su, Y.; Lin, M. Z.

10.1101/2025.03.30.646252 — bioengineering — Posted on 2025-04-02

4894 UniversalEPI: a generalized attention-based deep ensemble model to accurately predict enhancer-promoter interactions across diverse cell types and conditions

Grover, A.; Zhang, L.; Muser, T.; Häfliger, S.; Wang, M.; Yates, J.; Van Allen, E.; Theis, F. J.; Ibarra, I. L.; Krymova, E.; Boeva, V.

10.1101/2024.11.22.624813 — genomics — Posted on 2025-04-02

4895 Fitness seascapes are necessary for realistic modeling of the evolutionary response to drug therapy

King, E. S.; Stacy, A. E.; Weaver, D. T.; Maltas, J. A.; Barker-Clarke, R.; Dolson, E.; Scott, J. G.

10.1101/2022.06.10.495696 — evolutionary biology — Posted on 2025-04-02

4896 Correlated evolution of multiple traits gives butterflies a false head

Yumnam, T.; Kodandaramaiah, U.

10.1101/2024.11.25.624978 — evolutionary biology — Posted on 2025-04-02

4897 Small Extracellular Vesicle Signaling and Mitochondrial Transfer Reprograms T Helper Cell Function in Human Asthma

Hough, K. P.; Trevor, J. L.; Ahmad, S.; Wang, Y.; Chacko, B. K.; Goliwas, K. F.; Strenkowski, J. G.; Bone, N. B.; Kim, Y.-i.; Holmes, R.; Liu, Y.; Vang, S.; Pritchard, A.; Chin, J.; Bodduluri, S.; Antony, V. B.; Tousif, S.; Athar, M. S.; Chanda, D.; Mitra, K.; Zmijewski, J.; Zhang, J.; Duncan, S. R.; Thannickal, V. J.; Gabrielsson, S.; Darley-Usmar, V. M.; Deshane, J. S.

10.1101/2024.04.30.589227 — immunology — Posted on 2025-04-02

4898 Music-selective cortex is sensitive to structure in both pitch and time

Boebinger, D. L.; McDermott, J. H.; Kanwisher, N. G.; Norman-Haignere, S. V.

10.1101/2021.12.17.473232 — neuroscience — Posted on 2025-04-02

4899 An Open-Source Deep Learning-Based GUI Toolbox For Automated Auditory Brainstem Response Analyses (ABRA)

Erra, A.; Chen, J.; Miller, C.; Chrysostomou, E.; Barret, S.; Kassim, Y. M.; Friedman, R. A.; Lauer, A.; Ceriani, F.; Marcotti, W.; Carroll, C.; Manor, U.

10.1101/2024.06.20.599815 — neuroscience — Posted on 2025-04-02

4900 A bioprinting approach for high-throughput production of micropatterned neuroepithelial tissues and modeling TSC2-deficient brain malformations

Farahani, N. I.; Wong, K. K. L.; Allen, G.; Minhas, A.; Lin, L.; Nazir, S.; Julian, L. M.

10.1101/2025.03.31.646426 — neuroscience — Posted on 2025-04-02

4901 Mu and delta opioid receptor antagonists increase the expression of social conditioned place preference in early adolescent mice

Harda, Z.; Klimczak, M.; Misiolek, K.; Chroszcz, M.; Rzeszut, A.; Szumiec, L.; Jarosz, M. K.; Rygula, R.; Ziolkowska, B.; Parkitna, J. R.

10.1101/2023.07.19.549691 — neuroscience — Posted on 2025-04-02

4902 Goal-directed visual information processing with GABAergic inhibition in parietal cortex

Wang, Z.; Wiborg, S.; Wittman, A.; Beck, N.; Becker, M.; Frank, S. M.

10.1101/2025.03.26.645504 — neuroscience — Posted on 2025-04-02

4903 Cortical structure in relation to empathy and psychopathy in 800 incarcerated men

Radecki, M. A.; Maurer, J. M.; Harenski, K. A.; Stephenson, D. D.; Sampaolo, E.; Lettieri, G.; Handjaras, G.; Ricciardi, E.; Rodriguez, S. N.; Neumann, C. S.; Harenski, C. L.; Palumbo, S.; Pellegrini, S.; Decety, J.; Pietrini, P.; Kiehl, K. A.; Cecchetti, L.

10.1101/2023.06.14.543399 — neuroscience — Posted on 2025-04-02

4904 microRNA and non-targeted proteome analysis of liquid biopsies from the distal lung collected by Particles in Exhaled Air (PExA) reveals presence from extracellular vesicles

Bonatti, M.; Ezerskyte, M.; Lindberg, P.; Zohrer, B.; Kolosenko, I.; Vegvari, A.; Wheelock, A. M.

10.1101/2024.11.12.620657 — physiology — Posted on 2025-04-02

4905 Recurrent Composite Markers of Cell Types and States

Li, X.; Nguyen, J.; Korkut, A.

10.1101/2023.07.17.549344 — bioinformatics — Posted on 2025-04-02

4906 PMS2 has both pro-mutagenic and anti-mutagenic effects on repeat instability in the Repeat Expansion Diseases

Jimenez, D. A.; Miller, C. J.; Walker, A.; Anupindi, K.; Usdin, K.; Zhao, X.

10.1101/2024.08.13.607839 — genetics — Posted on 2025-04-02

4907 Pcdh20 is a POU2F3 target gene required for proper tuft cell microvillus formation

Ankenbauer, K. E.; Yang, Y.; Chung, C.-Y.; Andrade, L. R.; Weiser Novak, S.; Jarvis, B.; Ali Hanel, W. H.; Liu, J.; Sarkisian, V.; Dani, N.; Krystofiak, E.; Hu, G.; Ebrahim, S.; Kachar, B.; Gong, Q.; Wahl, G.; Manor, U.; Lau, K.; DelGiorno, K. E.

10.1101/2025.03.18.644042 — cell biology — Posted on 2025-04-02

4908 Genome reannotation and effector candidate identification in Meloidogyne chitwoodi through gland-specific transcriptome analysis

Teixeira, M.; Ko, I.; Bali, S.; Vieira, P.; Maier, T. R.; Baum, T. J.; Gleason, C.

10.1101/2025.03.27.645669 — molecular biology — Posted on 2025-04-02

4909 Common biological features of Mycobacterium tuberculosis MmpL3 inhibitors

Ames, L.; Allen, R.; Boshoff, H. I.; Cleghorn, L.; Engelhart, C. A.; Schnappinger, D.; Parish, T.

10.1101/2025.03.31.646319 — microbiology — Posted on 2025-04-02

4910 Structural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery

Haudiquet, M.; Chakravarti, A.; Zhang, Z.; Ramirez, J. L.; Herrero del Valle, A.; Olinares, P. D. B.; Lavenir, R.; Aït Ahmed, M.; de la Cruz, M. J.; Chait, B.; Sternberg, S. H.; Bernheim, A.; Patel, D.

10.1101/2025.04.02.646746 — microbiology — Posted on 2025-04-02

4911 Synaptic Gpr85 influences cerebellar granule cells electrical properties and light-induced behavior.

Darche-Gabinaud, R.; Kaafarani, A.; Chazalon, M.; Suain, V.; Hendrickx, E.; Conrard, L.; Lefort, A.; Libert, F.; Demirler, M. C.; Schiffmann, S.; Perez-Morga, D.; Wittamer, V.; Parmentier, M.; Pirson, I.

10.1101/2025.03.10.642364 — neuroscience — Posted on 2025-04-02

4912 RNAi-based screen for pigmentation in Drosophila melanogaster reveals regulators of brain dopamine and sleep

Deal, S. L.; Bei, D.; Gibson, S. B.; Delgado-Seo, H.; Fujita, Y.; Wilwayco, K.; Seto, E. S.; Yamamoto, S.

10.1101/2023.07.20.549932 — neuroscience — Posted on 2025-04-02

4913 Volatiles from low R:FR-treated maize plants increase the emission of herbivore-induced plant volatiles in their neighbors

Escobar Bravo, R.; Schimmel, B. C. J.; Erb, M.

10.1101/2024.10.05.616768 — plant biology — Posted on 2025-04-02

4914 Cell-autonomous and non-cell-autonomous effects of arginase-II on cardiac aging

Potenza, D. M.; Cheng, X.; AJALBERT, G.; Brenna, A.; Giraud, M.-N.; FROBERT, A.; Cook, S.; Mertz, K. D.; Yang, Z.; Ming, X.-F.

10.1101/2024.01.17.576017 — physiology — Posted on 2025-04-02

4915 Flow Currents Support Simple and Versatile Trail-Tracking Strategies

Hang, H.; Jiao, Y.; Merel, J.; Kanso, E.

10.1101/2023.12.15.571932 — biophysics — Posted on 2025-04-02

4916 Toward De Novo Protein Design from Natural Language

Dai, F.; You, S.; Wang, C.; Fan, Y.; Su, J.; Han, C.; Zhou, X.; Liu, J.; Qian, H.; Wang, S.; Zeng, A.; Wang, Y.; Lu, H.; Yuan, F.

10.1101/2024.08.01.606258 — bioengineering — Posted on 2025-04-02

4917 In vivo activation of the dia BGC allows consolidation of the biosynthetic pathways of diaporthin, dichlorodiaporthin, diaporthinic acid, and diaporthinol

Burger, I.; Leonhartsberger, S.; Peikert, K.; Fourtis, L.; Atanasova, P.; Kramer, L. T.; Fried, R.; Stanetty, C.; Rudroff, F.; Birner-Gruenberger, R.; Mach, R. L.; Mach-Aigner, A. R.; Schittmayer, M.; Zimmermann, C.

10.1101/2025.03.31.646288 — biochemistry — Posted on 2025-04-02

4918 Identifying the genetic basis and molecular mechanisms underlying phenotypic correlation between complex human traits using a gene-based approach

Gu, J.; Fuller, C. K.; Carbonetto, P.; He, X.; Zheng, J.; Li, H.

10.1101/2021.02.09.430368 — genetics — Posted on 2025-04-02

4919 QInfoMating: Sexual Selection and Assortative Mating Estimation Software

Carvajal-Rodriguez, A.

10.1101/2023.09.06.556585 — evolutionary biology — Posted on 2025-04-02

4920 Estimates of molecular convergence reveal genes with intermediate pleiotropy underlying adaptive variation across teleost fish

Barua, A.; Srivastava, M.; Beinsteiner, B.; Laudet, V.; Robinson-Rechavi, M.

10.1101/2024.06.24.600426 — evolutionary biology — Posted on 2025-04-02

4921 Sinoatrial Node Impulses Emerge From Incessant, Unique Kinetic Transitions In Disordered Local Calcium Dynamics

Tagirova, S.; Maltsev, A. V.; Baca, G. L.; Maltsev, V. A.; Bychkov, R.; Lakatta, E. G.

10.1101/2024.12.18.629224 — cell biology — Posted on 2025-04-02

4922 Filamentous cheater phages drive bacterial and phage populations to lower fitness

Kubota, N.; Scribner, M. R.; Cooper, V. S.

10.1101/2025.04.01.646652 — microbiology — Posted on 2025-04-02

4923 Lactuchelins: New lipopeptide siderophores from Pseudomonas lactucae inhibit Xanthomonas campestris pv. campestris 8004

Chesneau, G.; Noel, A.; Breard, D.; Boulanger, A.; Briand, M.; Bonneau, S.; Liu, Y.; Hendrickson, A.; Nielsen, T.; Sarniguet, A.; Guilet, D.; Arkin, A.; Lui, L.; BARRET, M.

10.1101/2025.02.28.640635 — microbiology — Posted on 2025-04-02

4924 ESAT-6 of Mycobacterium tuberculosis downregulates cofilin1, leads to filamentous actin enrichment and reduces the phagosome acidification in infected macrophages, which are partially reversed by a single methionine mutation

P P, M.; R J, R.; K C, S.; Mundayoor, S.

10.1101/2020.05.04.076976 — immunology — Posted on 2025-04-02

4925 Development of Non-Spatial Grid-Like Neural Codes Predicts Inference and Intelligence

Qu, Y.; Ou, J.; Pang, L.; Wu, S.; Luo, Y.; Behrens, T. E.; Liu, Y.

10.1101/2024.11.20.624569 — neuroscience — Posted on 2025-04-02

4926 Neuronal correlates of sleep in honey bees

Moguilner, S.; Tiraboschi, E.; Fantoni, G.; Strelevitz, H.; Soleimani, H.; Del Torre, L.; Hasson, U.; Haase, A.

10.1101/2024.10.11.617548 — neuroscience — Posted on 2025-04-02

4927 Response to Tabin et al-Concerns about ancient DNA sequences reported from a Late Pleistocene individual from Southeast Asia

Zhang, X.; He, Y.; Ji, X.; Su, B.

10.1101/2025.03.29.646132 — genomics — Posted on 2025-04-02

4928 CREPE (CREate Primers and Evaluate): a computational tool for large-scale primer design and specificity analysis

Pitsch, J. W.; Wirth, S. A.; Costantino, N. T.; Mejia, J.; Doss, R. M.; Yang, X.; Breuss, M. W.

10.1101/2025.03.28.646040 — genetics — Posted on 2025-04-02

4929 Advancing Biogeographical Ancestry Predictions Through Machine Learning

Heinzel, C. S.; Purucker, L.; Hutter, F.; Pfaffelhuber, P.

10.1101/2025.01.31.635898 — genetics — Posted on 2025-04-02

4930 Cell divisions both challenge and refine tissue boundaries in the Drosophila embryo

Castle, V.; Miles, M.; Fernandez-Gonzalez, R.; Erdemci-Tandogan, G.

10.1101/2025.03.31.646372 — developmental biology — Posted on 2025-04-02

4931 Evi1 is necessary for late activation of delta-notch signaling in sea urchin embryos

Anand, S.; McClay, D. R.

10.1101/2025.04.01.646662 — developmental biology — Posted on 2025-04-02

4932 Gene expression cartography of a developing neuronal structure

Tadini, L.; Younsi, L.; Holguera, I.; Simon, F.; Courgeon, M.; Konstantinides, N.

10.1101/2025.03.30.646184 — developmental biology — Posted on 2025-04-02

4933 Excessive chondrogenesis in the blastema initiates during hypomorphic limb regeneration in Xenopus froglet, but not during patterned limb regeneration in Xenopus tadpoles and newts

Kobari, S.; Yokoyama, H.; Kato, K.; Sato, R.; Kitagawa, N.; Sakamoto, J.; Kamei, Y.; Yokoyama, H.

10.1101/2025.03.29.646070 — developmental biology — Posted on 2025-04-02

4934 Axial Nephron Fate Switching Demonstrates a Plastic System Tunable on Demand

Achieng, M. A.; Schnell, J.; Fausto, C. C.; Csipan, R. L.; Thornton, M. E.; Grubbs, B. H.; Lindström, N. O.

10.1101/2025.03.29.646044 — developmental biology — Posted on 2025-04-02

4935 Integration of head and body orientations in the macaque superior temporal sulcus is stronger for upright bodies

Zafirova, Y.; Vogels, R.

10.1101/2024.12.30.630733 — neuroscience — Posted on 2025-04-02

4936 Microtubule detyrosination alters nuclear mechanotransduction and leads to pro-hypertrophic signaling in hypertrophic cardiomyopathy

Duursma, I.; Nollet, E. E.; Jansen, V. J.; Malone, J. A.; Bloem, J. S.; Bedi, K.; Margulies, K. B.; Schoonvelde, S. A. C.; Michels, M.; van der Wel, N. N.; van der Velden, J.; Kirby, T. J.; Kuster, D. W. D.

10.1101/2025.03.28.646061 — physiology — Posted on 2025-04-02

4937 Influenza viral infection at the plasma membrane is restricted by lipid composition

Mannsverk, S.; Villamil Giraldo, A.; Kasson, P. M.

10.1101/2025.03.28.645900 — biophysics — Posted on 2025-04-02

4938 NetAn: A Python Toolbox for Network-based Gene Annotation Enrichment

Ghemes, E.; Lubovac-Pilav, Z.; Magnusson, R.

10.1101/2023.09.05.556339 — bioinformatics — Posted on 2025-04-02

4939 Machine learning-predicted chromatin organization landscape across pediatric tumors

Gjoni, K.; Zhang, S.; Yan, R. E.; Zhang, B.; Miller, D.; Resnick, A.; Dahmane, N.; Pollard, K. S.

10.1101/2025.03.28.645984 — genomics — Posted on 2025-04-02

4940 Robust Phylogenetics

Liu, Q.; Minh, B. Q.; Lanfear, R.; Charleston, M. A.; Richards, S. A.; Holland, B. R.

10.1101/2025.04.01.646540 — evolutionary biology — Posted on 2025-04-02

4941 Cross-species insemination reveals mouse sperm ability to locate and cross the fish micropyle

Garibova, S.; Stickler, E.; AlAli, F.; Abdulla, M. A.; Sathappan, A.; Da'as, S.; Ghanem, L.; Portman, R.; Avella, M.

10.1101/2025.03.29.646094 — developmental biology — Posted on 2025-04-02

4942 Casein kinase 1δ-regulated formation of GVBs induces resilience to tau pathology-mediated protein synthesis impairment

Smits, J. F. M.; Ligthart, T. W.; Jorge-Oliva, M.; Middelhoff, S.; Schipper, F.; Garritsen, R.; Pita-Illobre, D.; Li, K. W.; Scheper, W.

10.1101/2025.03.28.645932 — neuroscience — Posted on 2025-04-02

4943 Mosquito Sex Separation using Complementation of Selectable Traits and Engineered Neo-Sex Chromosomes

Zaada, D. S.; Toren, O.; Krsticevic, F.; Haber, D. A.; Gildman, D.; Galpaz, N.; Haecker, I.; Schetelig, M. F.; Marois, E.; Arien, Y.; Papathanos, P. A.

10.1101/2025.03.30.646185 — synthetic biology — Posted on 2025-04-02

4944 Functional genomics of Campylobacter-host interactions in an intestinal tissue model reveals a small lipoprotein essential for flagellar assembly

Alzheimer, M.; Froschauer, K.; Svensson, S. L.; Koenig, F.; Hopp, E.; Drobnic, T.; Henderson, L. D.; Ribardo, D. A.; Hendrixson, D. R.; Bischler, T.; Beeby, M.; Sharma, C. M.

10.1101/2025.04.02.646747 — microbiology — Posted on 2025-04-02

4945 Metagenomics reveals fibre fermentation and AMR pathways in red grouse (Lagopus scotica) microbiota

Ahmad, A. A.; Fletcher, K.; Hesford, N.; Glendinning, L.

10.1101/2025.04.02.646739 — microbiology — Posted on 2025-04-02

4946 Nanopore direct RNA sequencing (DRS) of MS2 bacteriophages in E.coli throughout its life cycle reveals a complex transcriptional activity to control and maintain its growth

Ni, N.; Burgio, G.

10.1101/2025.03.30.646209 — microbiology — Posted on 2025-04-02

4947 Primary envelopment of Kaposi's sarcoma-associated herpesvirus at the nucleoplasmic reticulum

Wilson, A.; Ridgway, N.; McCormick, C.

10.1101/2025.04.01.646635 — microbiology — Posted on 2025-04-02

4948 Inflammasome activation dictates the efficacy of antimycobacterial activity of frontline TB drugs

Rao, V. K.; Singh, A.; Bisht, K.; Yadav, N.; Nanda, R.

10.1101/2025.04.02.646750 — microbiology — Posted on 2025-04-02

4949 In vivo efficacy of L-ascorbic acid in restricting cholera pathogenesis

Halder, P.; Sen, H.; Das, S.; Nandy, P.; Mukhopadhyay, A. K.; Withey, J. H.; Raychaudhuri, S.; Koley, H.

10.1101/2025.04.01.646656 — microbiology — Posted on 2025-04-02

4950 Structural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery

Haudiquet, M.; Chakravarti, A.; Zhiying, Z.; Ramirez, J. L.; Herrero del Valle, A.; Olinares, P. D. B.; Lavenir, R.; Aït Ahmed, M.; de la Cruz, M. J.; Chait, B.; Sternberg, S. H.; Bernheim, A.; Patel, D.

10.1101/2025.04.02.646746 — microbiology — Posted on 2025-04-02

4951 From omics to enhanced fungal virulence: Overexpression of a putative secreted protein improves Beauveria bassiana biocontrol potential against the insect pests Piezodorus guildinii and Tenebrio molitor

Oberti, H.; Sessa, L.; van Roosmalen, E.; de Bekker, C.; Seidl, M. F.; Sanchez-Vallet, A.; Abreo, E.

10.1101/2025.04.02.646755 — microbiology — Posted on 2025-04-02

4952 Immune-mediated indirect interaction between gut microbiota and bacterial pathogens

Keshavarz, M.; Franz, M.; Xie, H.; Zanchi, C.; Mbedi, S.; Sparmann, S.; Rolff, J.

10.1101/2025.03.31.646282 — immunology — Posted on 2025-04-02

4953 Neural activation down to the spinal cord during action language? A transcranial magnetic stimulation and peripheral nerve stimulation study.

Dupont, W.; Amiez, N.; Palluel-Germain, R.; Martin, A.; Perrone-Bertolotti, M.; Madden-Lombardi, C.; Lebon, F.

10.1101/2025.04.02.646751 — neuroscience — Posted on 2025-04-02

4954 Striatal neural ensemble codes for voluntary locomotor and involuntary dyskinetic movements

Chattree, G.; Chrapkiewicz, R.; Zhang, Y.; Li, J.; Schnitzer, M. J.

10.1101/2025.04.01.646527 — neuroscience — Posted on 2025-04-02

4955 A computational approach to understanding effort-based decision-making in depression

Valton, V.; Mkrtchian, A.; Moses-Payne, M.; Gray, A.; Kieslich, K.; VanUrk, S.; Samborska, V.; Halahakoon, D. C.; Manohar, S. G.; Dayan, P.; Husain, M.; Roiser, J. P.

10.1101/2024.06.17.599286 — neuroscience — Posted on 2025-04-02

4956 The third alpha helix of plant homeoproteins are generally cell-penetrating to plant cells

Squire, H. J.; Wang, J. W.-T.; Landry, M. P.

10.1101/2025.04.01.646723 — plant biology — Posted on 2025-04-02

4957 Plant genetic and root-associated microbial diversity modulate Lactuca sativa responsiveness to a soil inoculum under phosphate deficiency

Capparotto, A.; Salvucci, P.; Ciampanelli, A.; Sello, S.; Sudiro, C.; Clauw, P.; Altissimo, A.; Vuolo, F.; Giovannetti, M.

10.1101/2025.04.02.646582 — plant biology — Posted on 2025-04-02

4958 The multiomics landscape of small peptides encoded by long non-coding RNA-derived sORFs in rice

Chen, Z.; Lin, H.; Wei, L.; Wang, S.; Peng, T.; Song, W.; Wang, D.; Wu, Y.; Wu, L.; Wu, J.; Wang, Y.

10.1101/2025.04.01.646714 — plant biology — Posted on 2025-04-02

4959 Phycocyanobilin biosynthesis in Galdieria sulphuraria requires isomerization of phycoerythrobilin synthesized by bilin reductases

Frascogna, F.; Rockwell, N. C.; Hartmann, J.; Mudler, J.; Frankenberg-Dinkel, N.

10.1101/2025.04.02.646756 — plant biology — Posted on 2025-04-02

4960 Predicting Rhizosphere Competence Related Catabolic Gene Clusters in plant-associated bacteria with RhizoSMASH

Li, Y.; Sun, M.; Raaijmakers, J. M.; Mommer, L.; Zhang, F.; Song, C.; Medema, M. H.

10.1101/2025.03.29.646099 — bioinformatics — Posted on 2025-04-02

4961 Ancestral proteins trace the emergence of substrate specificity and oligomerization within bacterial DEDDy dinucleases

Mortensen, S.; Burnim, A.; Dufault-Thompson, K.; Lipka, A. E.; Jiang, X.; Sondermann, H.

10.1101/2025.03.30.646021 — evolutionary biology — Posted on 2025-04-02

4962 Resistance variation and bacterial interactions shape the adaptation of a genetically diverse bacterial population to antimicrobial treatment

Batra, A.; Tueffers, L.; Haas, K.; Loeblein, T.; Botelho, J.; Habig, M.; Schuetz, D.; Sakalyte, G.; Buchholz, F.; Berrios-Caro, E.; Uecker, H.; Unterweger, D.; Schulenburg, H.

10.1101/2025.04.01.646401 — evolutionary biology — Posted on 2025-04-02

4963 Molecular phylogeny of the SELMA translocation machinery recounts the evolution of complex photosynthetic eukaryotes.

Ponce-Toledo, R. I.; Moreira, D.; Lopez-Garcia, P.; Deschamps, P.

10.1101/2025.03.31.646294 — evolutionary biology — Posted on 2025-04-02

4964 Social evolution and absence of olfactory function in larval honey bees

Peng, T.; Chen, Z.; Ahmed, A. C.; Feng, Q.; Yeo, S.; Han, H.-S.; Robinson, G. E.

10.1101/2025.03.31.646396 — evolutionary biology — Posted on 2025-04-02

4965 Fighting Through the Heat: How Sexual Selection Influences Demography Under Recurrent Heatwaves

Porwal, N.; Parrett, J. M.; Kruszynska, A. S.; Pandey, N.; Knell, R. J.; Cameron, T. C.; Radwan, J.

10.1101/2025.03.31.646346 — evolutionary biology — Posted on 2025-04-02

4966 A novel protistan trait database reveals functional redundancy and complementarity in terrestrial protists (Amoebozoa & Rhizaria)

Freudenthal, J.; Schlegel, M.; Bonkowski, M.; Dumack, K.

10.1101/2025.03.28.645897 — ecology — Posted on 2025-04-02

4967 Lotka-Volterra Dynamics Facilitate Sustainable Biocontrol of Wastewater Sludge Bulking

Baltes, F.; Weiss, A.; Ettl, M.; Dumack, K.

10.1101/2025.03.29.646071 — ecology — Posted on 2025-04-02

4968 Impacts on the microbial fungal communities across water, sediment, and amphibian hosts across an urbanization gradient waterway in Worcester, Massachusetts

Wheeler, S. J.; DelCogliano, M.; Hare, B.; Bradshaw, A. J.; Hincher, M. R.; Carleton, J. P.; Bergmann, P. J.; Ahlgren, N. A.; Tabima, J. F.

10.1101/2025.04.01.646624 — ecology — Posted on 2025-04-02

4969 N-glycosylation Enables Smut Fungal Nge1 Orthologs to Prevent the Escape of Maize Evolved-PMEIs

Bhaskar, C.; Chau, M.-Q.; Tsai, W.-L.; Teh, O.-K.; Ma, L.-S.

10.1101/2025.04.01.646729 — microbiology — Posted on 2025-04-02

4970 Ultrasound-based prediction of spawning time in females of Octopus vulgaris

Marquez, L.; Weterings, P.; Saber, S.; Felipe, B. C.; Maccuro, S.; Serrano, M.; Seuntjens, E.; Acosta-Cifuentes, F.; Gonzalez, M.; Almansa, E.

10.1101/2025.03.28.645890 — zoology — Posted on 2025-04-02

4971 Two opposing redox signals mediated by 2-Cys peroxiredoxin shape the redox proteome during photosynthetic induction

Doron, S.; Lampl, N.; Savidor, A.; Pri-Or, A.; Katina, C.; Cejudo, F. J.; Levin, Y.; Rosenwasser, S.

10.1101/2025.04.02.646757 — plant biology — Posted on 2025-04-02

4972 Sub-zero temperatures during early spring migration in blue-spotted salamanders (Ambystoma laterale)

Giacometti, D.; Moldowan, P. D.; Tattersall, G. J.

10.1101/2025.03.28.645960 — physiology — Posted on 2025-04-02

4973 Attention Guided Mechanism Interpretable Drug-Gene Interaction (MIDI) Modeling for Cancer Drug Response Prediction and Target Effect Explanation

Wanyan, T.; Cai, L.; Nijhawan, D.; Posner, B.; Kim, J.; Yuan, R.; Wang, R.; Huang, J.; Yang, S.; Mallipeddi, P.; Wang, T.; Zhan, X.; Xiao, G.; Xie, Y.

10.1101/2025.03.31.646490 — cancer biology — Posted on 2025-04-02

4974 Female-biased vascular smooth muscle cell gene regulatory networks predict MYH9 as a key regulator of fibrous plaque phenotype

Perry, R. N.; Lenert, G.; Benavente, E. D.; Ma, A.; Barbera, N.; Mokry, M.; de Kleijn, D. P.; de Winther, M. P.; Mayr, M.; Bjorkegren, J. H.; den Ruijter, H. H.; Civelek, M.

10.1101/2025.03.28.645955 — genomics — Posted on 2025-04-02

4975 Two CENH3 paralogs in the green alga Chlamydomonas reinhardtii have a redundantly essential function and associate with ZeppL-LINE1 elements

Liu, D.; Wang, M.; Gent, J.; Sun, P.; Dawe, R. K.; Umen, J. G.

10.1101/2025.03.28.645958 — genetics — Posted on 2025-04-02

4976 Unfolding admixed ancestry and genomic diversity in zoo giraffes

Fraser, M. F.; Heller, R.; Bertola, L. D.; Hvilsom, C.; Balboa, R. F.; Liu, X.; Bruniche-Olsen, A.

10.1101/2025.03.31.645993 — evolutionary biology — Posted on 2025-04-02

4977 Higher-order equivalence of Lotka-Volterra and replicator dynamics

Gokhale, C. S.; Traulsen, A.

10.1101/2025.03.28.645916 — evolutionary biology — Posted on 2025-04-02

4978 Mating signal energy gradient mediates gene flow in the early stage of avian speciation

Eddo, D. D.; Hodur, Z. J.; Wang, S.

10.1101/2025.03.28.646037 — evolutionary biology — Posted on 2025-04-02

4979 Contrasting amphibian population trend from a protected area in Madagascar reveal severe underestimation of extinction risks

Porcel, X.; Crottini, A.; Freeman, K.; Noel, J.; Velo, J. H.; Lava, H.; Rendrirendry, G.; Andreone, F.; Dubos, N.

10.1101/2025.03.28.645942 — ecology — Posted on 2025-04-02

4980 CRISPR/Cas9-mediated generation of two isogenic CEP290-mutated iPSC lines

Figueiro-Silva, J.; Eschment, M.; Mennel, M.; Abidi, A.; Oneda, B.; Rauch, A.; Bachmann-Gagescu, R.

10.1101/2025.03.31.646311 — developmental biology — Posted on 2025-04-02

4981 Single Nucleus Multiome Analysis Reveals Early Inflammatory Response to High-Fat Diet in Mouse Pancreatic Islets

Ernst, I. V. S.; Lehtonen, L.; Nilsson, S. M.; Nielsen, F. L.; Marcher, A.-B.; Mandrup, S.; Madsen, J. G. S.

10.1101/2025.04.01.646568 — cell biology — Posted on 2025-04-02

4982 KIF20A cooperates with Myosin II to drive endosomal carriers fission and protein trafficking

Selot, J.; Lasbareilles, S.; Colasse, S.; Miserey, S.; Delevoye, C.; Thepot, J. S.; Karaiskou, A.

10.1101/2025.04.01.646333 — cell biology — Posted on 2025-04-02

4983 Modeling the zebrafish gut microbiome's resistance and sensitivity to climate change and parasite infection

Sieler, M. J.; Al-Samarrie, C. E.; Kasschau, K. D.; Kent, M. L.; Sharpton, T. J.

10.1101/2025.03.28.644597 — microbiology — Posted on 2025-04-02

4984 A multiplex real-time PCR assay for detection of equine herpesvirus 1 and equine herpesvirus 4

Tallmadge, R. L.; Laverack, M. A.; Crossley, B. M.; Diel, D. G.

10.1101/2025.03.31.646299 — microbiology — Posted on 2025-04-02

4985 Pilidium lythri disrupts plant microbiome assembly under climate warming: Evidence for niche-specific community reassembly

Siegieda, D.; Panek, J.; Hannula, E. S.; Frac, M.

10.1101/2025.01.28.633866 — microbiology — Posted on 2025-04-02

4986 Compartment size and proliferation shape the murine T cell receptor repertoire in splenic T- and B cell zones during an immune response

Buytenhuijs, F.; Tune, C.; Schampel, A.; Schierloh, L.-K.; Pagel, R.; Westermann, J.; Textor, J.

10.1101/2025.03.28.645898 — immunology — Posted on 2025-04-02

4987 Substrate stiffness and shear stress collectively regulate the inflammatory phenotype in cultured human brain microvascular endothelial cells

Yates, A.; Murray, H.; Kjar, A.; Chavarria, D.; Masters, H.; Kim, H.; Ligocki, A.; Jefferson, A.; Lippmann, E.

10.1101/2025.03.31.646228 — neuroscience — Posted on 2025-04-02

4988 Homeostatic Activation of 26S Proteasomes by Protein Kinase A Protects against Cardiac and Neurobehavior Malfunction in Alzheimer's Disease Mice

Chakroborty, A.; Ejaz, S.; Sternburg, J. O.; Asadi, Y.; Cai, M.; Dwamena, A. A.; Giri, S.; Adeniji, O.; Ahammed, M. S.; Gilstrap, E. A.; Uddin, M. G.; McDowell, C.; Liu, J.; Wang, H.; Wang, X.

10.1101/2025.03.28.645869 — physiology — Posted on 2025-04-02

4989 DEVELOPMENT OF PROTOCOLS FOR DEPOSITING A RARE PLANT SPECIES OF THE ROSTOV REGION, THYMUS CALCAREUS KLOKOV & DES. SHOST.

Chokheli, V. A.; Tulupov, K. A.; Azarov, A. S.; Belyaev, M. O.; Tsymerskaia, C. A.; Sushkova, S. N.

10.1101/2025.03.31.646457 — physiology — Posted on 2025-04-02

4990 Epigenetic Modulation, Intra-tumoral Microbiome and Immunity in Early Onset Colorectal Cancer

Jin, N.; Hoyd, R.; Yilmaz, A. S.; Zhu, J.; Liu, Y.; Singh, M. J.; Grencewicz, D.; Mo, X.; Kalady, M.; Rosenberg, D.; Dravillas, C. E.; Singer, E. A.; Carpten, J. D.; Chan, C. H.; Churchman, M. L.; Denko, N. C.; Di Clemente, F.; Dodd, R. D.; Eljilany, I.; Fei, N.; Hardikar, S.; Ikeguchi, A. P.; Ma, A.; Ma, Q.; McCarter, M. D.; Osman, A. E.; Riedlinger, G.; Robinson, L. A.; Schneider, B. P.; Tarhini, A. A.; Tinoco, G.; Figueiredo, J.; Zakharia, Y.; Ulrich, C. M.; Tan, A. C.; Spakowicz, D.

10.1101/2025.03.28.645992 — cancer biology — Posted on 2025-04-02

4991 Serotonergic Modulation of Motoneuronal Excitability and Its Impact on Muscle Force Generation: A Computational Study

Melendez-Gallardo, J.; Plada-Delgado, D.

10.1101/2025.04.01.646607 — bioinformatics — Posted on 2025-04-02

4992 Protocol for Extracting Circulating Cell-Free DNA from Murine Saliva: Insights into Oral and Systemic Disease Research

Elamin, I.; Rao, M. S.; Figliozzi, R. W.; Maahs, J. C.; Balish, M.; Hsia, S. V.; Fugolin, A. P. P.; Fan, J.

10.1101/2025.03.31.645839 — genomics — Posted on 2025-04-02

4993 Extinction vortices are driven more by a shortage of beneficial mutations than by deleterious mutation accumulation

Mawass, W.; Matheson, J.; Hernandez, U.; Berg, J. J.; Masel, J.

10.1101/2024.10.25.620329 — evolutionary biology — Posted on 2025-04-02

4994 Optogenetic and chemical genetic tools for rapid repositioning of vimentin intermediate filaments

Pasolli, M.; Meiring, J. C. M.; Conboy, J. P.; Koenderink, G.; Akhmanova, A.

10.1101/2024.11.21.624725 — cell biology — Posted on 2025-04-02

4995 Filamentous cheater phages drive bacterial and phage populations to lower fitness

Kubota, N. S.; Scribner, M. R.; Cooper, V. S.

10.1101/2025.04.01.646652 — microbiology — Posted on 2025-04-02

4996 Interplay between T3SS effectors, ExoY activation, and cGMP signaling in Pseudomonas aeruginosa infection

Deruelle, V.; Dupuis, G.; Raoux-Barbot, D.; Lim, E.; Ponce-Lopez, R.; Ladant, D.; Renault, L.; Mechold, U.

10.1101/2025.03.26.645418 — microbiology — Posted on 2025-04-02

4997 Synergistic reinforcement learning by cooperation of the cerebellum and basal ganglia

Yohida, T.; Sugino, H.; Yamamoto, H.; Tanno, S.; Tamura, M.; Igarashi, J.; Isomura, Y.; Hira, R.

10.1101/2024.07.12.603330 — neuroscience — Posted on 2025-04-02

4998 On variability in local field potentials

Parto-Dezfouli, M.; Johnson, E. L.; Psarou, E.; Bosman, C. A.; Krishna, B. S.; Fries, P.

10.1101/2025.03.27.645661 — neuroscience — Posted on 2025-04-02

4999 DEVELOPMENT OF PROTOCOLS FOR THE CULTIVATION OF WORMWOOD (ARTEMISIA SALSOLOIDES)

Chokheli, V. A.; Azarov, A. S.; Petrenko, V. S.; Belyaev, M. O.; Tulupov, K. A.; Tsymerskaia, C. A.; Sushkova, S. N.

10.1101/2025.03.31.646446 — physiology — Posted on 2025-04-02

5000 Selective targeting of oncogenic KRAS G12D using peptide nucleic acid oligomers attached to cell-penetrating peptides

Mondal, J.; Lam, D.; Gerritsen, M. E.; Brotz, T. M.; Kennedy, J. G.; Rehlaender, B.; Ross, A. J.; Levy, D. E.; Bonagura, C. A.; Lanzilotta, W. N.; McCormick, F.; Rothman, J. H.; Wolfe, A. L.

10.1101/2025.03.28.645837 — cancer biology — Posted on 2025-04-02

5001 Systematic discovery of directional regulatory motifs associated with human insulator sites

Osato, N.; Hamada, M.

10.1101/2024.01.20.573595 — bioinformatics — Posted on 2025-04-02

5002 Building A Unified Model for Drug Synergy Analysis Powered by Large Language Models

Liu, T.; Chu, T.; Luo, X.; Zhao, H.

10.1101/2024.04.08.588634 — bioinformatics — Posted on 2025-04-02

5003 Learning multi-cellular representations of single-cell transcriptomics data enables characterization of patient-level disease states

Liu, T.; De Brouwer, E.; Kuo, T.; Diamant, N.; Missarova, A.; Wang, H.; Hao, M.; Biancalani, T.; Bravo, H. C.; Scalia, G.; Regev, A.; Heimberg, G.

10.1101/2024.11.18.624166 — bioinformatics — Posted on 2025-04-02

5004 Transcranial Functional Ultrasound Imaging Detects Focused Ultrasound Neuromodulation Induced Hemodynamic Changes In Vivo

Bendig, J.; Aurup, C.; Blackman, S. G.; McCune, E. P.; Kim, S.; Konofagou, E. E.

10.1101/2024.03.08.583971 — bioengineering — Posted on 2025-04-02

5005 Variations in kinase and effector signaling logic in a bacterial two component signaling network

Swingle, D.; Epstein, L.; Aymon, R.; Isiorho, E. A.; Abzalimov, R. R.; Favaro, D. C.; Gardner, K. H.

10.1101/2024.11.04.621962 — biochemistry — Posted on 2025-04-02

5006 Predicting the DNA binding specificity of transcription factor mutants usingfamily-level biophysically interpretable machine learning

Liu, S.; Gomez-Alcala, P.; Leemans, C.; Glassford, W. J.; Melo, L. A. N.; Lu, X.-J.; Mann, R. S.; Bussemaker, H. J.

10.1101/2024.01.24.577115 — genomics — Posted on 2025-04-02

5007 Transcriptomic landscape reveals immunity related trade-offs in an invertebrate-fungal host-parasite system

Paraskevopoulou, S.; Gattis, S.; Ben-Ami, F.

10.1101/2025.03.28.645961 — evolutionary biology — Posted on 2025-04-02

5008 Forecasting protein evolution by integrating birth-death population models with structurally constrained substitution models

Ferreiro, D.; Gonzalez-Vazquez, L. D.; Prado-Comesana, A.; Arenas, M.

10.1101/2025.02.21.639428 — evolutionary biology — Posted on 2025-04-02

5009 Characterisation of the historic demographic decline of the British European polecat population

Shaw, R. L.; MacPherson, J.; Kitchener, A. C.; Etherington, G. J.; Haerty, W. W.

10.1101/2024.10.30.621102 — evolutionary biology — Posted on 2025-04-02

5010 CCDC32 stabilizes clathrin-coated pits and drives their invagination

Yang, Z.; Yang, C.; Huang, Z.; Xu, P.; Li, Y.; Han, L.; Peng, L.; Wei, X.; Pak, J.; Svitkina, T.; Schmid, S. L.; Chen, Z.

10.1101/2024.06.26.600785 — cell biology — Posted on 2025-04-02

5011 Hierarchical glycolytic pathways control the carbohydrate utilization regulator in human gut Bacteroides

Kabonick, S. G.; Verma, K.; Modesto, J. L.; Pearce, V. H.; Winokur, K. M.; Groisman, E. A.; Townsend, G. E.

10.1101/2024.11.13.623061 — microbiology — Posted on 2025-04-02

5012 A minimal CRISPR polymerase produces decoy cyclic nucleotides to detect phage anti-defense proteins

Sullivan, A. E.; Nabhani, A.; Schinkel, K.; Dinh, D. M.; Duncan, M. L.; Ednacot, E. M. Q.; Hoffman, C. R. K.; Izrailevsky, D. S.; Kibby, E. M.; Nagy, T. A.; Nguyen, C. M.; Tak, U.; Burroughs, A. M.; Aravind, L.; Whiteley, A. T.; Morehouse, B. R.

10.1101/2025.03.28.646047 — microbiology — Posted on 2025-04-02

5013 Bone marrow mesenchymal stromal cells mediate cellular inflammation in HFpEF

Mentkowski, K.; Lee, I.-H.; Rohde, D.; Paccalet, A.; Seung, H.; Kumowski, N.; Schloss, M. J.; Carpenito-Kronenfeld, M.; Kaushal, V.; Jain, R.; Memcaj, X.; Wiebe, J.; Momin, N.; Pabel, S.; Muse, C. G.; Tuy, K.; Ung, S.; Roh, J.; Swirski, F. K.; Scadden, D.; van Galen, P.; Kreso, A.; Naxerova, K. N.; Hulsmans, M.; Nahrendorf, M.

10.1101/2025.03.28.645924 — immunology — Posted on 2025-04-02

5014 Optimized CART Cell Therapy for Metastatic Aggressive Thyroid Cancer

Gleba, J. J.; Siegler, E. L.; Manriquez-Roman, C.; DeFranco, G. E.; Huynh, T. N.; Mai, L. K.; Miller, J. L.; Miller, E. E.; Pawlush, M. L.; Alasonyalilar Demirer, A.; Kimball, B. L.; Tapper, E. E.; Sakemura, R. L.; Stewart, C. M.; Can, I.; Sirpilla, O. L.; Feigin, J. M.; Yun, K.; Gutierrez-Ruiz, O. L.; Xia, H.; Hefazi, M.; Schick, K. J.; Ogbodo, E. J.; Olivier, G.; Qiu, Y.; Tun, H. W.; Smallridge, R. C.; Zubair, A.; Copland, J. A.; Kenderian, S. S.

10.1101/2024.03.15.585286 — immunology — Posted on 2025-04-02

5015 Progressive multi-stage extrapolation of predictable motion in human visual cortex

Turner, W.; Sexton, C.; Johnson, P. A.; Wilson, E.; Hogendoorn, H.

10.1101/2024.04.22.590502 — neuroscience — Posted on 2025-04-02

5016 Ykt6 SNARE protein drives GluA1 insertion at synaptic spines during LTP

Takahashi, M.; Caraveo, G.

10.1101/2025.02.10.632800 — neuroscience — Posted on 2025-04-02

5017 Hierarchical Processing of Natural Scenes in the Human Pulvinar

Guest, D. R.; Allen, E. J.; Kay, K. N.; Arcaro, M. J.

10.1101/2025.03.20.644381 — neuroscience — Posted on 2025-04-02

5018 Perturbation-response analysis of in silico metabolic dynamics in nonlinear regime: Hard-coded responsiveness in the cofactors and network sparsity

Himeoka, Y.; Furusawa, C.

10.1101/2023.10.18.562862 — systems biology — Posted on 2025-04-02

5019 Long-context Protein Language Modeling Using Bidirectional Mamba with Shared Projection Layers

Wang, Y.; Wang, Z.; Sadeh, G.; Zancato, L.; Achille, A.; Karypis, G.; Rangwala, H.

10.1101/2024.10.29.620988 — synthetic biology — Posted on 2025-04-02

5020 ELF3 controls trait heterogeneity by tuning the rate of maturation in Arabidopsis and barley

McCarthy, K.; Pook, H.; Redmond, E. J.; Ronald, J.; Keir, J.; Zhu, Z.; Quint, M.; Davis, P. A.; Hartley, S. E.; Davis, S.; Ezer, D.

10.1101/2025.03.24.644900 — plant biology — Posted on 2025-04-02

5021 Semaglutide interferes with postnatal development of juvenile mice with compromised growth

Joly, A.; Rebiffe, L.; Dusabyinema, Y.; Dellinger, J.; Leulier, F.; De Vadder, F.

10.1101/2024.05.06.592704 — physiology — Posted on 2025-04-02

5022 Mapping cellular targets of covalent cancer drugs in the entire mammalian body

Pang, Z.; Leung, V. H.; Wang, C. C.; Attarpour, A.; Rinaldi, A.; Shen, H.; Glynn, C.; Sigua, L. H.; Yender, M.; Selke, A.; Xu, S.; Wu, P.; Goubran, M.; Cravatt, B. F.; Ye, L.

10.1101/2025.03.28.645991 — pharmacology and toxicology — Posted on 2025-04-02

5023 Dose- and time-dependent effects of cobalt protoporphyrin IX on granulocyte mobilization and metabolic markers in mice

Bednarz, A.; Kozuch, P.; Kowalski, K.; Skulimowska, I.; Kachamakova-Trojanowska, N.; Filipek-Gorzala, J.; Kwiecinska, P.; Garcia Garcia, R.; Gawlinska, K.; Malezyna, K.; Kubiak, A.; Bryniarska-Kubiak, N.; Jozkowicz, A.; Szade, K.; Szade, A.

10.1101/2024.10.22.619673 — pharmacology and toxicology — Posted on 2025-04-02

5024 Lack of consistent effect of dietary fiber on immune checkpoint blockade efficacy across diverse murine tumor models

Roichman, A.; Reyes-Castellanos, G.; Chen, Z.; Chen, Z.; Mitchell, S. J.; MacArthur, M. R.; Sawant, A.; Levett, L.; Powers, J.; Gomez, M.; Ibrahim, M.; Xu, X.; Tomlinson, B.; Hang, X.; Wei, Y.; Kang, Y.; White, E.; Rabinowitz, J. D.

10.1101/2025.03.28.645975 — cancer biology — Posted on 2025-04-02

5025 Substrate stiffness regulates triple-negative breast cancer signaling through CXCR4 receptor dynamics

Ho, K. K. Y.; Buschhaus, J. M.; Zhang, A.; Cutter, A. C.; Humphries, B.; Luker, G. D.

10.1101/2025.03.28.645920 — cancer biology — Posted on 2025-04-02

5026 Futile wound healing drives mesenchymal-like cell phenotypes in human glioblastoma

Mossi Albiach, A.; Janusauskas, J.; Kjaer Jacobsen, J.; Kapustova, I.; Karamzadeh, R.; Kvedaraite, E.; Hu, L.; Franck, M. C.; Mannens, C.; Codeluppi, S.; Munting, J. B.; Borm, L. E.; Shamikh, A.; Lonnerberg, P.; Siletti, K. A.; Persson, O.; Linnarsson, S.

10.1101/2023.09.01.555882 — cancer biology — Posted on 2025-04-02

5027 (A)symmetry in the Allele-Specific Chromosomal Structural Dynamics during Embryogenesis

Feng, C.; Chu, X.

10.1101/2025.03.28.645915 — biophysics — Posted on 2025-04-02

5028 PCNA encircling primer/template junctions is eliminated by exchange of RPA for Rad51: Implications for the interplay between human DNA damage tolerance pathways

Norris, J.; Rogers, L. O.; Young, G.; Pytko, K. G.; Dannenberg, R. L.; Perreault, S.; Kaushik, V.; Antony, E.; Hedglin, M.

10.1101/2025.03.27.645792 — biophysics — Posted on 2025-04-02

5029 Predicting microbial transcriptome using genome sequence

FU, G.; YAN, Y.; CHEN, Y.; SHAO, B.

10.1101/2024.12.30.630741 — bioinformatics — Posted on 2025-04-02

5030 Novel universal domain-centric method for protein classification

Fadaei, S.; Krebs, F. S.; Zoete, V.

10.1101/2025.03.28.645719 — bioinformatics — Posted on 2025-04-02

5031 biscot: an Optimal Transport framework for multimodal bacterial single-cell data analysis

Feldl, M.; Abbaszade, G.; Schattenberg, F.; Stuckrath, K.; Mueller, S.; Mueller, C. L.

10.1101/2025.03.28.645895 — bioinformatics — Posted on 2025-04-02

5032 The bacterial chaperone CsgC inhibits functional amyloid CsgA formation by promoting the intrinsically disordered pre-nuclear state

Balistreri, A.; Kolli, D.; Jayaweera, S. W.; Lundahl, D.; Han, Y.; Kalcec, L.; Goetzler, E.; Alessio, R.; Ruotolo, B.; Olofsson, A.; Chapman, M. R.

10.1101/2025.03.21.644623 — biochemistry — Posted on 2025-04-02

5033 Customizing the Structure of a Minimal TIM Barrel to Craft a De Novo Enzyme

Beck, J.; Smith, B. J.; Zarifi, N.; Freund, E.; Chica, R. A.; Hoecker, B.

10.1101/2025.01.28.635154 — biochemistry — Posted on 2025-04-02

5034 Phosphate-binding pocket on cyclin B governs CDK substrate phosphorylation and mitotic timing

Ng, H. Y.; Whelpley, D. H.; Adly, A. N.; Maxwell, R. A.; Morgan, D. O.

10.1101/2024.02.28.582599 — biochemistry — Posted on 2025-04-02

5035 Bayesian analysis and efficient algorithms for single-molecule fluorescence data and step counting

Mattamira, C.; Ward, A.; Krishnan, S. T.; Lamichhane, R.; Barrera, F. N.; Sgouralis, I.

10.1101/2025.03.04.641510 — biochemistry — Posted on 2025-04-02

5036 Discovery and chemical optimisation of a Potent, Bi-cyclic (Bicycle(R)) Antimicrobial Inhibitor of Escherichia coli PBP3

Rowland, C. E.; Newman, H.; Martin, T. T.; Dods, R.; Bournakas, N.; Wagstaff, J. M.; Lewis, N.; Stanway, S. J.; Balmforth, M.; Kessler, C.; van Rietschoten, K.; Bellini, D.; Roper, D. I.; Lloyd, A. J.; Dowson, C. G.; Skynner, M. J.; Beswick, P.; Dawson, M. J.

10.1101/2024.03.20.581580 — biochemistry — Posted on 2025-04-02

5037 AI-Driven System for Large-Scale Automated Collection of Mouse Profile Images

Ozawa, N.; Sakai, Y.; Sakai, Y.; Koshimoto, C.; Shiozawa, S.

10.1101/2025.03.27.645835 — animal behavior and cognition — Posted on 2025-04-02

5038 KhufuEnv, an auxiliary toolkit for building computational pipelines for plant and animal breeding

Wright, H. C.; Davis, C. E. M.; Clevenger, J.; Korani, W.

10.1101/2025.03.28.645917 — genomics — Posted on 2025-04-02

5039 Evolution into chaos - implications of the trade-off between transmissibility and immune evasion

Sayyar, G.; Garab, A.; Rost, G.

10.1101/2024.06.29.601333 — evolutionary biology — Posted on 2025-04-02

5040 Adaptive challenges of past and future invasion of Drosophila suzukii: insights from novel genomic resources and statistical methods combining individual and pool sequencing data

Camus, L.; Rode, N. O.; Serga, S.; Loiseau, A.; Chen, X.; Iampietro, C.; Kenis, M.; Marande, W.; Mensch, J.; Parrinello, H.; Savic Veselinovic, M.; Valiere, S.; Zhang, J.; Estoup, A.; Boitard, S.; Gautier, M.

10.1101/2024.10.11.617812 — evolutionary biology — Posted on 2025-04-02

5041 Long-lasting coexistence of multiple asexual lineages alongside their sexual counterparts in a fungal plant pathogen

Abdalrahem, A.; Andrieux, A.; Becheler, R.; Duplessis, S.; Frey, P.; Marcais, B.; Stoeckel, S.; Halkett, F.

10.1101/2025.03.28.645883 — evolutionary biology — Posted on 2025-04-02

5042 Multiple bursts of speciation in Madagascar's endangered lemurs

Everson, K. M.; Pozzi, L.; Barrett, M. A.; Blair, M. E.; Donohue, M. E.; Kappeler, P. M.; Kitchener, A. C.; Lemmon, A. R.; Lemmon, E. M.; Pavon-Vazquez, C. J.; Radespiel, U.; Randrianambinina, B.; Rasoloarison, R. M.; Rasoloharijaona, S.; Roos, C.; Salmona, J.; Yoder, A. D.; Zenil-Ferguson, R.; Zinner, D.; Weisrock, D. W.

10.1101/2023.04.26.537867 — evolutionary biology — Posted on 2025-04-02

5043 Tracking the phenology of riverine insect communities using environmental DNA

Cereghetti, E.; Ajvazi, X.; Keck, F.; Patrignani, A.; Tartini, N.; Altermatt, F.; Carraro, L.

10.1101/2025.01.10.632357 — ecology — Posted on 2025-04-02

5044 Growth directions and stiffness across cell layers determine whether tissues stay smooth or buckle

Singh Yadav, A.; Hong, L.; Klees, P. M.; Kiss, A.; Petit, M.; He, X.; Barrios, I. M.; Heeney, M.; Galang, A. M. D.; Smith, R. S.; Boudaoud, A.; Roeder, A. H. K.

10.1101/2023.07.22.549953 — developmental biology — Posted on 2025-04-02

5045 Canonical Wnt pathway modulation is required to correctly execute multiple independent cellular dynamic programs during cranial neural tube closure

Bogart, A. H.; Brooks, E. R.

10.1101/2024.12.19.629501 — developmental biology — Posted on 2025-04-02

5046 Loss of cholesterol in Junctional Epidermolysis Bullosa skin identifies a key role for Laminin-332 in actomyosin mediated cholesterol transport

Jones, E. M.; Camera, E.; Parzymies, P.; Marsh, S. T.; O'Shaughnessy, R. F.; Aumailley, M.; McGrath, J. A.; O'Toole, E. A.; Caley, M. P.

10.1101/2023.09.10.557030 — cell biology — Posted on 2025-04-02

5047 Autoregulation of RPL7B by inhibition of a structural splicing enhancer

Stormo, G. D.; Granas, D.; Hewa, I. G.; White, M. A.

10.1101/2025.03.14.643126 — molecular biology — Posted on 2025-04-02

5048 Diversity and varying predation capacities of Amoebozoa against opportunistic vibrios in contrasting Mediterranean coastal environments.

Robino, E.; Perret, A.; Noel, C.; Haffner, P.; Intertaglia, L.; Richard, M.; Descamps, N.; Sellier, A.; Onillon, L.; Lebaron, P.; Destoumieux-Garzon, D.; Charriere, G. M.

10.1101/2025.03.14.643055 — microbiology — Posted on 2025-04-02

5049 Impact of low-calorie sweeteners on gut bacteria is modulated by common xenobiotics

Blasche, S.; Periwal, V.; Covarrubias, N. B.; Lindell, A.; Roux, I.; Kamrad, S.; Bradley, R.; Guan, R.; Ozgur, H.; Ramachandran, B.; Benes, V.; Patil, K. R.

10.1101/2025.03.28.645995 — microbiology — Posted on 2025-04-02

5050 Efficacy and mechanism of action of cipargamin as an antibabesial drug candidate

Li, H.; Ji, S.; Ariefta, N. R.; Galon, E. M. S.; El-Sayed, S. A.; Do, T.; Jia, L.; Sakaguchi, M.; Asada, M.; Nishikawa, Y.; Qin, X.; Liu, M.; Xuan, X.

10.1101/2024.07.15.603500 — microbiology — Posted on 2025-04-02

5051 Explosive cytotoxicity of 'ruptoblasts' bridges hormonal surveillance and immune defense

Chai, C.; Sultan, E.; Sarkar, S. R.; Zhong, L.; Sarfati, D. N.; Gershoni-Yahalom, O.; Jacobs-Wagner, C.; Rosental, B.; Wang, B.

10.1101/2025.03.28.645876 — immunology — Posted on 2025-04-02

5052 Alternative splicing generates a Ribosomal Protein S24 isoform induced by neuroinflammation and neurodegeneration

Magadi, S. S.; Jonson, M.; Maqdissi, J. A.; Kaczmarczyk, L.; Zijlstra, J. J.; Perkins, M.; Paul, G.; Hallbeck, M.; Ingelsson, M.; Watts, J. C.; Reichenbach, N.; Petzold, G. C.; Lucena, P. B.; Heneka, M. T.; Jackson, W. S.

10.1101/2025.03.28.645676 — neuroscience — Posted on 2025-04-02

5053 A novel critic signal in identified midbrain dopaminergic neurons of mice training in operant tasks

Matsumoto, J.; Oberto, V.; Pompili, M. N.; Todorova, R.; Papaleo, F.; Nishijo, H.; Venance, L.; Vandecasteele, M.; Wiener, S. I.

10.1101/2024.05.06.592735 — neuroscience — Posted on 2025-04-02

5054 Time-resolved functional genomics using deep learning reveals a global hierarchical control of autophagy

Chica, N.; Andersen, A. N.; Orellana-Munoz, S.; Garcia, I.; Nguea P, A.; Nakken, S.; Ayuda-Duran, P.; Hakensbakken, L.; Schultz, S. W.; Rodningen, E.; Putnam, C. D.; Zucknick, M.; Rusten, T. E.; Enserink, J. M.

10.1101/2024.04.06.588104 — systems biology — Posted on 2025-04-02

5055 Repeated acoustic stimuli induce decentralized transcriptional memory for robust priming of plant defense.

Hadj-Amor, K.; Leger, O.; Raffaele, S.; Kovacic, M.; Duclos, A.; Carvalho-Silva, P.; Garcia, F.; Barbacci, A.

10.1101/2024.05.03.592392 — plant biology — Posted on 2025-04-02

5056 FUSE-PhyloTree: Linking functions and sequence conservation modules of a protein family through phylogenomic analysis

Dennler, O.; Chenel, E.; Coste, F.; Blanquart, S.; Belleannee, C.; Theret, N.

10.1101/2025.03.28.645931 — bioinformatics — Posted on 2025-04-02

5057 Light-field deep learning enables high-throughput, scattering-mitigated calcium imaging

Howe, C. L.; Zhao, K. L. Y.; Verinaz-Jadan, H.; Song, P.; Barnes, S. J.; Dragotti, P. L.; Foust, A. J.

10.1101/2025.03.17.643718 — bioengineering — Posted on 2025-04-02

5058 Can we tell where our bodies end and the world begins? Evidence for precise three dimensional internal body models

Blaise, C. R.; Clark, H. C.; Saal, H. P.

10.1101/2025.03.28.645649 — animal behavior and cognition — Posted on 2025-04-02

5059 A new genome assembly of the pea cultivar Cameor provides resources for functional genomics and genetics

Kreplak, J.; Novak, P.; Robledillo, L. A.; AUBERT, G.; Imbert, B.; Kaur, P.; Gouil, Q.; Lopez-Roques, C.; Rodde, N.; BOUCHEZ, O.; Tayeh, N.; Macas, J.; Burstin, J.

10.1101/2025.04.01.645976 — genomics — Posted on 2025-04-02

5060 The information content of species: formal definitions of pangenome complexity track with bacterial lifestyle

Narechania, A.; Bobo, D.; Gilbert, T.; Gopalakrishnan, S.

10.1101/2025.03.28.645969 — genomics — Posted on 2025-04-02

5061 The essential role of connective-tissue cells during axolotl limb regeneration

Garcia-Garcia, D.; Knapp, D.; Kim, M.; Jamwal, K.; Fuqua, H.; Seaman, R. P.; Grindle, R. E.; Nowoshilow, S.; Novatchkova, M.; Kolling, F. W.; Graber, J. H.; Murawala, P.

10.1101/2025.03.30.645595 — developmental biology — Posted on 2025-04-02

5062 Milk-derived extracellular vesicles mitigate NF-κB pathway and NLRP3 inflammasome formation in Long Evans neonates.

Lu, J.; Storm, J. A.; Obtial, M. F.; Wijenayake, S.

10.1101/2025.03.30.645467 — developmental biology — Posted on 2025-04-02

5063 REPOP: bacterial population quantification from platecounts

Pessoa, P.; Lu, C.; Tashev, S. A.; Kruithoff, R.; Shepherd, D. P.; Presse, S.

10.1101/2025.04.01.644179 — microbiology — Posted on 2025-04-02

5064 Cytomegalovirus-induced T cell responses accelerate Alzheimer's disease progression in mice

Marsden, M.; McLaren, J. E.; Bevan, R. J.; Penn-Ripley, D.; Somerville, M.; Lauder, S. N.; Gallimore, A.; Price, D. A.; Miners, K. L.; Ladell, K.; Siebzehnrubl, F. A.; Hughes, T. R.; Humphreys, I. R.; Clement, M.

10.1101/2025.03.28.645902 — immunology — Posted on 2025-04-02

5065 Olfactory dysfunction in a novel model of prodromal Parkinson's disease in adult zebrafish

Vorhees, N. W.; Groenwold, S. L.; Williams, M. T.; Putt, L. S.; Sanchez-Gama, N.; Stalions, G. A.; Taylor, G. M.; Van Dort, H. E.; Calvo-Ochoa, E.

10.1101/2025.03.29.645796 — neuroscience — Posted on 2025-04-02

5066 Comprehensive Atomic-Scale 3D Viral-Host Protein Interactomes Enable Dissection of Key Mechanisms and Evolutionary Processes Underlying Viral Pathogenesis

Li, L.; Roy, P. G.; Liu, Y.; Zhang, Z.; Xiong, D.; Savan, R.; Gokhale, N. S.; Schang, L. M.; Das, J.; Yu, H.

10.1101/2025.03.28.645946 — systems biology — Posted on 2025-04-02

5067 Overnutrition directly impairs thyroid hormone biosynthesis and utilization, causing hypothyroidism, despite remarkable thyroidal adaptations

Rampy, J.; Torres-Manzo, A. P.; Hoffsmith, K.; Loberg, M. A.; Sheng, Q.; Salas-Lucia, F.; Bianco, A. C.; Arrojo e Drigo, R.; Wang, H.; Weiss, V. L.; Carrasco, N.

10.1101/2025.03.31.645596 — physiology — Posted on 2025-04-02

5068 A computational workflow for assessing drug effects on temporal signaling dynamics reveals robustness in stimulus-specific NFκB signaling

Bozich, E. R.; Guo, X.; Wilson, J. L.; Hoffmann, A.

10.1101/2025.03.31.645599 — pharmacology and toxicology — Posted on 2025-04-02

5069 Cell and nuclear size are associated with chromosomal instability and tumorigenicity in cancer cells that undergo whole genome doubling

Bloomfield, M.; Huth, S.; McCausland, D.; Saad, R.; Bano, N.; Chau, T. N.; Sweet, M.; Baudoin, N. C.; McCaffrey, A.; Fluet, K.; Schmelz, E. M.; Ben-David, U.; Cimini, D.

10.1101/2025.03.28.645986 — cancer biology — Posted on 2025-04-02

5070 Loss-of-Function genetic Screen Unveils Synergistic Efficacy of PARG Inhibition with Combined 5-Fluorouracil and Irinotecan Treatment in Colorectal Cancer

Queralt, C.; Moreta-Moraleda, C.; Costa, M.; Grau-Leal, F.; Diesch, J.; Vendrell-Ayats, C.; Musulen, E.; Buges, C.; Manzano, J. L.; Cabrero, S.; Zuber, J.; Buschbeck, M.; Forcales, S.-V.; Martinez-Balibrea, E.

10.1101/2025.03.29.644889 — cancer biology — Posted on 2025-04-02

5071 Generative Landscapes and Dynamics to Design Multidomain Artificial Transmembrane Transporters

Ortega, F. M.; Hossain, F.; Volobouev, V. V.; Meloni, G.; Torabifard, H.; Morcos, F.

10.1101/2025.03.28.645293 — biophysics — Posted on 2025-04-02

5072 In-Silico Stability Predictors: Investigation of Performance Towards balanced Experimental Data

Degn, K.; Utichi, M.; Besora, P. S.-I.; Tiberti, M.; Papaleo, E.

10.1101/2025.03.28.645695 — bioinformatics — Posted on 2025-04-02

5073 Compact lens-based dual-channel adaptive optics scanning laser ophthalmoscopy for in-vivo three-dimensional retinal imaging in mice

Li, Z.; Mary, S.; Johnson, T. V.; Yi, J.

10.1101/2025.03.31.645335 — bioengineering — Posted on 2025-04-02

5074 Functional Neural Connectivity of the Mouse Brain using Photoacoustic Ultrasound Imaging

Clark, I. H.; Heinmiller, A.; Zhu, W.; Zhu, X.-H.; Strell, P.; Roushdy, Z.; Vernekar, M.; Johnson, S.; Natera, D.; Sun, K.; Wiesner, H.; Haney, K.; Grande, A. w.; Low, W. C.; Chen, W.

10.1101/2025.03.31.645325 — bioengineering — Posted on 2025-04-02

5075 The speed of information processing at memory competitions: limited by reading in short tasks and declining as a power law for longer times

Wiederhold, B.

10.1101/2025.03.31.646314 — neuroscience — Posted on 2025-04-01

5076 A canonical cortical electronic circuit for neuromorphic intelligence

Maryada, ; De Luca, C.; Rubino, A.; Wen, C.; Cartiglia, M.; Fodorut, I.-I.; Payvand, M.; Indiveri, G.

10.1101/2025.03.28.646019 — neuroscience — Posted on 2025-04-01

5077 Concurrent multimodal measurement of excitation and inhibition shows that EEG-based estimates are linked to the ratio of glutamate to GABA

Cochrane, A.; Rosedahl, L.; Tamaki, M.; Watanabe, T.; Sasaki, Y.

10.1101/2025.03.31.646339 — neuroscience — Posted on 2025-04-01

5078 Released mitochondrial DNA and neurofilament light chain as Parkinson's disease phenotypes in patient-specific midbrain assembloids

Sabate-Soler, S.; Rosety, I.; Gomez-Giro, G.; Ghelfi, J.; Hezzaz, S.; Grunewald, A.; Schwamborn, J. C.; Jarazo, J.

10.1101/2025.03.28.645921 — neuroscience — Posted on 2025-04-02

5079 The developing retina undergoes mitochondrial remodeling via PINK1/PRKN-dependent mitophagy

Zapata-Munoz, J.; Jimenez-Loygorri, J. I.; Stumpe, M.; VILLAREJO ZORI, B.; Boya, P.; Alonso-Gil, S.; Teresak, P.; Mathai, B. J.; Ganley, I. G.; Simonsen, A.; Dengjel, J.

10.1101/2025.03.30.646079 — developmental biology — Posted on 2025-04-01

5080 Benchmarking Genetic Interaction Scoring Methods for Identifying Synthetic Lethality from Combinatorial CRISPR Screens

Ajmal, H. B.; Nandi, S. B.; Kebabci, N. B.; Ryan, C.

10.1101/2025.03.31.645224 — bioinformatics — Posted on 2025-04-01

5081 Integration of Alzheimer's GWAS, 3D genomics, and single-cell CRISPRi non-coding screen implicates causal variants in a microglial enhancer regulating TSPAN14.

Laub, S.; Tulina, N.; Hoffman, M.; Faryean, J.; Ramachandran, S.; Trang, K.; Lewkiewicz, S.; Chesi, A.

10.1101/2025.04.01.646442 — genetics — Posted on 2025-04-01

5082 Altered Protein Phosphorylation in a Novel Midbrain Organoid Model for Bipolar Disorder

Meyer, K.; Woodworth, M.; Goncalves, M. C. B.; Yue, M.; AlJandal, H.; Morton, S.; Lewandowski, M.; Liu, N.; Zigon, E.; Fortuna, P.; Garcia-Corral, M.; Budnik, B.; Church, G. M.; Tam, J. M.

10.1101/2025.04.01.646642 — cell biology — Posted on 2025-04-01

5083 parafac4microbiome: Exploratory analysis of longitudinal microbiome data using Parallel Factor Analysis

van der Ploeg, G. R.; Westerhuis, J.; Heintz-Buschart, A.; Smilde, A.

10.1101/2024.05.02.592191 — microbiology — Posted on 2025-04-01

5084 Deep learning recognises antibiotic modes of action from brightfield images

Krentzel, D.; Kho, K.; Petit, J.; Mahtal, N.; Shorte, S. L.; Wehenkel, A. M.; Boneca, I. G.; Zimmer, C.

10.1101/2025.03.30.645928 — microbiology — Posted on 2025-04-01

5085 Reduced gravity and muon radiation affect Caenorhabditis elegans life history traits and viral infection

Villena-Gimenez, A.; Castiglioni, V. G.; Legarda, E. G.; Munoz-Sanchez, J. C.; Gonzalez, R.; Elena, S. F.

10.1101/2024.10.03.616447 — microbiology — Posted on 2025-04-01

5086 Interpretable Inflammation Landscape of Circulating Immune cells

Jimenez-Gracia, L.; Maspero, D.; Aguilar-Fernandez, S.; Craighero, F.; Boulougouri, M.; Ruiz, M.; Marchese, D.; Caratu, G.; Linares-Blanco, J.; Berasategi, M.; Ramirez Flores, R. O.; Sanzo-Machuca, A.; M. Corraliza, A.; A. Tran, H.; Normand, R.; Nestor, J.; Hong, Y.; Kole, T.; van der Velde, P.; Alleblas, F.; Pedretti, F.; Aterido, A.; Banchero, M.; Soriano, G.; Roman, E.; van den Berge, M.; Salas, A.; Carrascosa, J. M.; Fernandez Nebro, A.; Domenech, E.; Canete, J.; Tornero, J.; P. Gisbert, J.; Choy, E.; Girolomoni, G.; Siegmund, B.; Julia, A.; Serra, V.; Elosua, R.; Tejpar, S.; Vidal, S.; Na

10.1101/2023.11.28.568839 — immunology — Posted on 2025-04-01

5087 Decoding the Human Brain during Intelligence Testing

Thiele, J. A.; Faskowitz, J.; Sporns, O.; Chuderski, A.; Jung, R.; Hilger, K.

10.1101/2025.04.01.646660 — neuroscience — Posted on 2025-04-01

5088 Sounds and Sights in Sequence Learning: Can Accessory Auditory Cues Enhance Motor Task Performance?

Leow, L.-A.; Nguyen, A.; Corti, E. J.; Marinovic, W.

10.1101/2024.10.07.617139 — neuroscience — Posted on 2025-04-01

5089 Translating brain anatomy and neurodegenerative disease from mouse to human through latent gene expression space

Jaroszynski, C. Y. G.; Amer, M.; Beauchamp, A.; Lerch, J. P.; Sotiropoulos, S.; Mars, R. B.

10.1101/2025.03.31.646307 — neuroscience — Posted on 2025-04-01

5090 SIMPL: Scalable and hassle-free optimisation of neural representations from behaviour

George, T. M.; Glaser, P.; Stachenfeld, K.; Barry, C.; Clopath, C.

10.1101/2024.11.11.623030 — neuroscience — Posted on 2025-04-01

5091 Testosterone differentially modulates the display of agonistic behavior and dominance over opponents before and after adolescence in male Syrian hamsters

Castaneda, A. J.; Whitten, C. J.; Menard, T. A.; Sisk, C. L.; Cooper, M. A.; Schulz, K. M.

10.1101/2025.03.31.646499 — neuroscience — Posted on 2025-04-01

5092 Abrupt and gradual changes in neuronal processing upon falling asleep and awakening

Marmelshtein, A.; Lavy, B.; Hadad, B.; Nir, Y.

10.1101/2024.02.06.579189 — neuroscience — Posted on 2025-04-01

5093 Graph models of brain state in deep anaesthesia reveal sink state dynamics of reduced spatiotemporal complexity

Wilsenach, J.; Deane, C. M.; Reinert, G.; Warnaby, K.

10.1101/2024.08.21.608935 — neuroscience — Posted on 2025-04-01

5094 Cognitive reserve linked to network-specificbrain-ventricle coupling

Campo, F. F.; Brattico, E.; Miguel, V.; Magalhaes, V.; Nigro, S.; Tafuri, B.; the Alzheimer's Disease Neuroimaging Initiative, ; Logroscino, G.; Cabral, J.

10.1101/2025.01.04.631289 — neuroscience — Posted on 2025-04-01

5095 B4 Raf-like MAPKKK RAF24 regulates Arabidopsis thaliana flowering time through HISTONE MONO-UBIQUITINATION 2

Li, Q.; Wang, L.; Grubb, L. E.; Talasila, M.; Rodriguez Gallo, M. C.; Mehta, D.; Scandola, S.; Uhrig, R. G.

10.1101/2024.06.12.598286 — plant biology — Posted on 2025-04-01

5096 BRAF/MEK Inhibition Induces Cell State Transitions Boosting Immune CheckpointSensitivity in BRAFV600E-mutant Glioma

Xing, Y. L.; Panovska, D.; Park, J.-W.; Grossauer, S.; Koeck, K.; Bui, B.; Nasajpour, E.; Nirschl, J. J.; Feng, Z.-P.; Cheung, P.; Habib, P.; Wei, R.; Wang, J.; Thomason, W.; Xiu, J.; Beck, A.; Weber, K.; Harter, P. N.; Lim, M.; Mahaney, K.; Prolo, L. M.; Grant, G. A.; Ji, X.; Walsh, K. M.; Mulcahy Levy, J. M.; Hambardzumyan, D.; Petritsch, C. K.

10.1101/2023.02.03.526065 — cancer biology — Posted on 2025-04-01

5097 A miniature CRISPR-Cas10 enzyme confers immunity by an inverse signaling pathway

Doherty, E. E.; Adler, B. A.; Yoon, P. H.; Hsieh, K.; Loi, K.; Armbruster, E. G.; Lahiri, A.; Bolling, C. S.; Wilcox, X. E.; Akkati, A.; Iavarone, A. T.; Pogliano, J.; Doudna, J. A.

10.1101/2025.03.28.646030 — biochemistry — Posted on 2025-04-01

5098 Overcoming the "feast or famine" effect: improved interaction testing in genome-wide association studies

Zhou, H.; McPeek, M. S.

10.1101/2024.02.13.580168 — genetics — Posted on 2025-04-01

5099 Genome structural variation in natural Caenorhabditis elegans populations

Lesack, K. J.; Wasmuth, J. D.

10.1101/2025.01.07.631790 — evolutionary biology — Posted on 2025-04-01

5100 An initial report of c241,000 to 335,000 Year old Rock Engravings and their relation to Homo naledi in the Rising Star cave system, South Africa

Berger, L. R.; Hawks, J.; Fuentes, A.; van Rooyen, D.; Tsikoane, M.; Mpete, M.; Nkwe, S.; Molopyane, K.

10.1101/2023.06.01.543133 — evolutionary biology — Posted on 2025-04-01

5101 Landscape and regulation of new protein translation in the early C. elegans embryo

Shukla, Y.; Ghatpande, V.; Hu, C. F.; Dickinson, D. J.; Cenik, C.

10.1101/2024.12.13.628416 — developmental biology — Posted on 2025-04-01

5102 Negative regulation of miRNAs sorting in EVs: the RNA-binding protein PCBP2 impairs SYNCRIP-mediated miRNAs EVs loading

Marocco, F.; Garbo, S.; Montaldo, C.; Colantoni, A.; Quattrocchi, L.; Gaboardi, G.; Sabarese, G.; Cicchini, C.; Lecce, M.; Carnevale, A.; Paolini, R.; Tartaglia, G. G.; Battistelli, C.; Tripodi, M.

10.1101/2024.11.15.623754 — molecular biology — Posted on 2025-04-01

5103 Tandem sulfofucolytic-sulfolactate sulfolyase pathway for catabolism of the rare sulfosugar sulfofucose

Stewart, A.; Li, J.; Lee, M.; Lewis, J. M.; Herisse, M.; Hofferek, V.; McConville, M. J.; Pidot, S. J.; Scott, N. E.; Williams, S. J.

10.1101/2023.08.01.551581 — microbiology — Posted on 2025-04-01

5104 Combining a rhesus cytomegalovirus/SIV vaccine with neutralizing antibody to protect against SIV challenge in rhesus macaques

Coppola, J.; Parren, M.; Bastidas, R.; Saye-Francisco, K.; Malvin, J.; Jardine, J. G.; Gilbride, R. M.; Ojha, S.; Feltham, S.; Morrow, D.; Barber-Axthelm, A.; Bochart, R.; Fast, R.; Oswald, K.; Shoemaker, R.; Lifson, J. D.; Picker, L. J.; Burton, D. R.; Hansen, S. G.

10.1101/2025.03.20.644395 — immunology — Posted on 2025-04-01

5105 Synaptopathy in the TDP43ΔNLS Mouse Model of Sporadic Amyotrophic Lateral Sclerosis

Ayvazian-Hancock, A.; Butler, E.; Meehan, C. F.; Miles, G. B.; Broadhead, M. J.

10.1101/2025.03.25.645173 — neuroscience — Posted on 2025-04-01

5106 Behavioral timescale synaptic plasticity in the hippocampus creates non-spatial representations during learning and is modulated by entorhinal inputs

Dorian, C. C.; Taxidis, J.; Arac, A.; Golshani, P.

10.1101/2024.08.27.609983 — neuroscience — Posted on 2025-04-01

5107 Multi-timescale motor circuit dynamics underlies adaptive and efficient exploratory behavior

Li, P.; Zhang, H.; Su, Y.; Wang, J.; Tao, L.; Wen, Q.

10.1101/2024.11.18.624064 — neuroscience — Posted on 2025-04-01

5108 On-Demand Seizures Facilitate Rapid Screening of Therapeutics for Epilepsy

Chen, Y.; Litt, B.; Vitale, F.; Takano, H.

10.1101/2024.08.26.609726 — neuroscience — Posted on 2025-04-01

5109 A Meta-Analysis of Functional Neuroimaging Tasks associated with Perceptual Pseudoneglect

Abdul-Nabi, M.; Niemeier, M.

10.1101/2025.02.04.636501 — neuroscience — Posted on 2025-04-01

5110 Competence for transcellular infection in the root cortex involves a post-replicative, cell-cycle exit decision in Medicago truncatula

Batzenschlager, M.; Lace, B.; Zhang, N.; Su, C.; Boiger, A.; Egli, S.; Krohn, P.; Salfeld, J.; Ditengou, F. A.; Laux, T.; Ott, T.

10.1101/2023.03.28.534635 — plant biology — Posted on 2025-04-01

5111 T Cell Receptor Diversity, Cancer and Sex: Insights from 30,000 TCRβ Repertoires

Zahid, H. J.; Taniguchi, R.; Noceda, M. G.; Robbins, H.; Greissl, J.

10.1101/2024.10.21.619470 — cancer biology — Posted on 2025-04-01

5112 Total whole-arm chromosome losses predict malignancy in human cancer

Zheng, Y.; Ahmad, K.; Henikoff, S.

10.1101/2025.03.09.642243 — cancer biology — Posted on 2025-04-01

5113 Optical sectioning for reflection interference microscopy

Ventalon, C.; Kirichuk, O.; Navon, Y.; Chastagnier, Y.; Heux, L.; Richter, R. P.; Bureau, L.; Debarre, D.

10.1101/2024.06.07.598038 — biophysics — Posted on 2025-04-01

5114 Enhancing CAR-T cell activity prediction via fine-tuning protein language models with generated CAR sequences

Yoshida, K.; Hisada, S.; Takase, R.; Okuma, A.; Ishida, Y.; Kawara, T.; Miura-Yamashita, T.; Ito, D.

10.1101/2025.03.27.645831 — bioinformatics — Posted on 2025-04-01

5115 Using artificial intelligence to optimize ecological restoration for climate and biodiversity

Silvestro, D.; Goria, S.; Groom, B.; Jacobsson, P.; Sterner, T.; Antonelli, A.

10.1101/2025.01.31.635975 — bioinformatics — Posted on 2025-04-01

5116 Sustained neurotrophic factor cotreatment enhances donor and host retinal ganglion cell survival in mice

Soucy, J. R.; Oswald, J.; Kriukov, E.; Phay, M.; Masland, J.; Pernstich, C.; Baranov, P.

10.1101/2024.03.07.583961 — bioengineering — Posted on 2025-04-01

5117 Crystal structures of forty- and seventy-one-substitution variants of hydroxynitrile lyase from rubber tree

Pierce, C. T.; Tan, P.; Greenberg, L. R.; Walsh, M. E.; Shi, K.; Nguyen, A.; Meixner, E. L.; Sarak, S.; Aihara, H.; Evans, R. L.; Kazlauskas, R. J.

10.1101/2025.03.30.646168 — biochemistry — Posted on 2025-04-01

5118 Protein-interaction network analysis reveals a role of Prp19 splicing factor in transcription of both intron-containing and intron-lacking genes

Dwyer, K.; Essak, M.-A.; Awada, A.; Dhoondia, Z.; Ansari, A.

10.1101/2025.03.31.646471 — biochemistry — Posted on 2025-04-01

5119 Force transmission through the inner kinetochore is enhanced by centromeric DNA sequences

Miedlar, E.; Hamilton, G. E.; Witus, S. R.; Gonske, S. J.; Riffle, M.; Zelter, A.; Klevit, R. E.; Asbury, C. L.; Dimitrova, Y. N.; Davis, T. N.

10.1101/2024.11.13.623448 — biochemistry — Posted on 2025-04-01

5120 Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases

Liu, J.; Shah, A.; Liu, X.; Wort, J. L.; Ma, Y.; Hardman, K.; Johansson, N. G.; De Castro Ribeiro, O. M.; Brookfield, A.; Bowen, A.; Yli-Kauhaluoma, J.; Xhaard, H.; Jeuken, L.; Goldman, A.; Pliotas, C.; Vidilaseris, K.

10.1101/2024.07.26.605302 — biochemistry — Posted on 2025-04-01

5121 Decoding sequence determinants of gene expression in diverse cellular and disease states

Lal, A.; Karollus, A.; Gunsalus, L.; Garfield, D.; Nair, S.; Tseng, A. M.; Gordon, M. G.; Blischak, J. D.; Van de Geijn, B.; Bhangale, T.; Collier, J. L.; Diamant, N.; Biancalani, T.; Corrada Bravo, H.; Scalia, G.; Eraslan, G.

10.1101/2024.10.09.617507 — genomics — Posted on 2025-04-01

5122 A high-quality reference genome for the Ural Owl (Strix uralensis) enables investigations of cell cultures as a genomic resource for endangered species

Chrysostomakis, I.; Mozer, A.; Bruno Di-Nizo, C.; Fischer, D.; Sargheini, N.; von der Mark, L.; Huettel, B.; Astrin, J. J.; Toepfer, T.; Boehne, A.

10.1101/2025.01.22.633903 — genomics — Posted on 2025-04-01

5123 Zombie Gene Flow: Asexual Hybrids Mediate Extensive Genomic Introgression from Extinct Species Into Their Sexual Parent

Vukic, J.; Marta, A.; Matura, F.; Kulik, D.; Eisner, J.; Sanda, R.; Tichopad, T.; Choleva, L.; Perdices, A.; Roslein, J.; Koci, J.; Shumka, S.; Ulqini, D.; Kotusz, J.; Dedukh, D.; Janko, K.

10.1101/2025.03.28.645731 — evolutionary biology — Posted on 2025-04-01

5124 Experimental approach to assessing the impact of the intensity of near-natural heatwaves on three marine phanerogam species in Mediterranean lagoon environment

Bourdier, C.; De Wit, R.; Soissons, L.; De Ronne, E.; Ouisse, V.

10.1101/2025.03.26.645255 — ecology — Posted on 2025-04-01

5125 Scalable environmental DNA methods reveal associations between landscape-scale forest habitat and insect richness

Richardson, R.; Avalos, G.; Garland, C.; Trott, R.; Hager, O.; Hepner, M.; Goodell, K.

10.1101/2025.04.01.645213 — ecology — Posted on 2025-04-01

5126 Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling

Hanna, J.; Touahri, Y.; Pak, A.; Belfiore, L.; van Oosten, E.; David, L. A.; Han, S.; Ilnytskyy, Y.; Kovalchuk, I.; Kurrasch, D.; Okawa, S.; del Sol, A.; Screaton, R. A.; Aubert, I.; Schuurmans, C.

10.1101/2024.07.12.603298 — developmental biology — Posted on 2025-04-01

5127 Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate Ciona

Hozumi, A.; Totsuka, N. M.; Onodera, A.; Wang, Y.; Hamada, M.; Shiraishi, A.; Satake, H.; Horie, T.; Hotta, K.; Sasakura, Y.

10.1101/2024.04.09.588679 — developmental biology — Posted on 2025-04-01

5128 A Commander-independent function of COMMD3 in endosomal trafficking

Squiers, G. T.; Wan, C.; Gorder, J.; Puscher, H.; Shen, J.

10.1101/2024.12.12.628173 — cell biology — Posted on 2025-04-01

5129 The Kinesin-14 Tail: Dual microtubule binding domains drive spindle morphogenesis through tight microtubule cross-linking and robust sliding

Ems-McClung, S. C.; Cassity, M.; Prasannajith, A.; Walczak, C. E.

10.1101/2025.02.25.640188 — cell biology — Posted on 2025-04-01

5130 Mutations that prevent phosphorylation of the BMP4 prodomain impair proteolytic maturation of homodimers leading to lethality in mice

Kim, H.-s.; Sanchez, M. L.; Silva, J.; Schubert, H. L.; Dennis, R.; Hill, C. P.; Christian, J. L.

10.1101/2024.10.08.617306 — cell biology — Posted on 2025-04-01

5131 The break in the cycle: Inositol pyrophosphate fluxomics disentangled via mathematical modelling

Hermes, J.; Kim, G.-D.; Liu, G.; De Leo, M. G.; Mayer, A.; Jessen, H. j.; Timmer, J.

10.1101/2025.03.27.645712 — molecular biology — Posted on 2025-04-01

5132 In-vivo Efficacy of a Phage Cocktail Therapy that Targets ESBL-producing Klebsiella Urinary Tract Infections Clinical Isolates

Jariah, R. O. A.; Schofield, J.; West, K.; Michniewski, S.; Jameson, E.; Onions, L.; Saravanan, A.; Yesilkaya, H.; Millard, A. D.; Clokie, M. R. J.; Haines, M. E. K.

10.1101/2025.04.01.646603 — microbiology — Posted on 2025-04-01

5133 SNX-BAR proteins 5 and 6 are required for NCOA7-AS antiviral activity against influenza A virus

Arnaud-Arnould, M.; Rebendenne, A.; Tauziet, M.; Urbach, S.; El Koulali, K.; Ricci, E. P.; Wencker, M.; Moncorge, O.; Blaise, M.; Goujon, C.

10.1101/2025.04.01.646557 — microbiology — Posted on 2025-04-01

5134 Synergistic biodegradation of polyethylene by experimentally evolved bacterial biofilms

Li, S.; Su, L.; Liu, J.; Qiu, J.; Lin, L.; Kovacs, A. T.; Lin, Y.

10.1101/2025.04.01.646683 — microbiology — Posted on 2025-04-01

5135 Odoribacter splanchnicus mitigates Salmonella-induced gut inflammation and its associated pathogenesis via its secreted bacteriocin

Hajra, D.; Mukherjee, D.; Vij, R.; Rajmani, R. S.; Dadireddy, V.; Das, D.; Hussain, T.; Ganji, M.; Tatu, U.; Chakravortty, D.

10.1101/2024.08.23.609322 — microbiology — Posted on 2025-04-01

5136 Contrastive Learning Enables Epitope Overlap Predictions for Targeted Antibody Discovery

Holt, C. M.; Janke, A. K.; Amlashi, P. B.; Marinov, T. M.; Georgiev, I. S.

10.1101/2025.02.25.640114 — immunology — Posted on 2025-04-01

5137 CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovium tissue

Liu, F.; Shi, H.; Turner, J. D.; Anscombe, R.; Sekine, T.; Hammitzsch, A.; Agarwal, D.; Mahony, C.; Chen, J.; Kendrick, B.; Du, D.; Tong, Q.; Duan, L.; Dooley, K.; Fang, H.; Korsunsky, I.; Madhu, R.; Cribbs, A.; consortium, C.; Friedrich, M.; Marsden, B. D.; Chen, Y.-L.; Ogg, G.; Adams, A.; Chen, W.; Leonardo, S.; McCann, F. E.; Buckley, C.; Rooney, T.; Freeman, T.; Uhlig, H. H.; Dendrou, C.; Croft, A.; Filer, A.; Bowness, P.; Chen, L.

10.1101/2024.10.11.617865 — immunology — Posted on 2025-04-01

5138 Acute aerobic exercise intensity does not modulate pain potentially due to differences in fitness levels and sex effects - results from a pharmacological fMRI study

Nold, J. I.; Fadai, T.; Buechel, C.

10.1101/2024.06.25.600579 — neuroscience — Posted on 2025-04-01

5139 Adaptive learning via BG-thalamo-cortical circuitry

He, Q.; Scott, D. N.; Frank, M. J.; Calderon, C. B.; Nassar, M. R.

10.1101/2025.03.13.643078 — neuroscience — Posted on 2025-04-01

5140 Balancing safety and efficiency in human decision making

Mahajan, P.; Tong, S.; Lee, S. W.; Seymour, B.

10.1101/2024.01.23.576678 — neuroscience — Posted on 2025-04-01

5141 Exercise Evokes Retained Motor Performance without Neuroprotection in a Mouse Model of Parkinson's Disease

Skelton, H. M.; Hyman, N.; Fernandez, A.; Acerbo, E.; Scott, M.; Berglund, K.; Gutekunst, C.-A.; Gross, R. E.

10.1101/2024.09.20.614034 — neuroscience — Posted on 2025-04-01

5142 Relevance of Nonlinear Dimensionality Reduction for Efficient and Robust Spike Sorting

Suarez-Barrera, D.; Bayones, L.; Parra, S.; Monroy, V.; Pujalte, S.; Andrade-Ortega, B.; Diaz, H.; Alvarez, M.; Zainos, A.; Franci, A.; Rossi-Pool, R.

10.1101/2025.03.27.645844 — neuroscience — Posted on 2025-04-01

5143 Tau-Associated Neuronal Loss in the Intermediate Nucleus of the Human Hypothalamus (VLPO Analog): Unveiling the Basis of NREM Sleep Dysfunction in PSP and Alzheimer's Disease

Rastegar-Pouyani, S.; Lew, C.; Pereira, F.; Satpati, A.; Paes, V.; Leite, R. P.; Suemoto, C.; Spina, S.; Seeley, W. W.; Heinsen, H.; Walsh, C.; Neylan, T.; Grinberg, L. T.

10.1101/2025.03.11.642707 — neuroscience — Posted on 2025-04-01

5144 Working memory readout varies with frontal theta rhythms

Han, H.-B.; Brincat, S. L.; Buschman, T. J.; Miller, E. K.

10.1101/2025.03.27.645781 — neuroscience — Posted on 2025-04-01

5145 Histone H3 as a redox switch in the nucleosome core particle: insights from molecular modeling

Karami, Y.; Gonzalez Aleman, R.; Duch, M.; Qiu, Y.; Kedjar, Y.; Bignon, E.

10.1101/2024.10.07.616940 — biophysics — Posted on 2025-04-01

5146 AlphaSync is an enhanced AlphaFold structure database synchronized with UniProt

Lang, B.; Babu, M. M.

10.1101/2025.03.12.642845 — bioinformatics — Posted on 2025-04-01

5147 The targeting of non-fibrillar polyQ via distinct VCP-proteasome coupling

Zhao, Y.; Mi, C.; Wagner, J.; Jiang, W.; Poege, M.; Saha, I.; Xu, P.; Plitzko, J.; Guo, Q.; Beck, F.; Baumeister, W.

10.1101/2025.04.01.646186 — biochemistry — Posted on 2025-04-01

5148 Human mitochondrial ferritin exhibits highly unusual iron-O2 chemistry distinct from that of cytosolic ferritins

Bradley, J. M.; Bugg, Z.; Pullin, J.; Moore, G. R.; Svistunenko, D. A.; Le Brun, N. E.

10.1101/2025.03.31.646379 — biochemistry — Posted on 2025-04-01

5149 Direct Amide Bond Formation By A Spore Peptidoglycan Biosynthetic Enzyme

Hopkins, M. E.; Yasinov, Z.; Fakler, M. J.; Wilde, G. E.; Wetmore, K. G.; Welsh, M. A.

10.1101/2025.03.28.644612 — biochemistry — Posted on 2025-04-01

5150 FAST RESENSITIZATION OF G PROTEIN-COUPLED RECEPTORS REQUIRESTHEIR PI(4,5)P2-DEPENDENT SORTING INTO AN AP2 POSITIVE COMPARTMENT

Gulyas, G.; Baba, T.; Toth, D.; Inoue, A.; Balla, T.

10.1101/2025.03.28.645988 — biochemistry — Posted on 2025-04-01

5151 AI-Driven System for Large-Scale Automated Collection of Mouse Profile Images

Ozawa, N.; Sakai, Y.; Sakai, Y.; Koshimoto, C.; Shiozawa, S.

10.1101/2025.03.27.645835 — animal behavior and cognition — Posted on 2025-04-01

5152 Prior Cuing Affects Saccades to Targets in the Praying Mantis, Sphodromantis lineola

Robert, T.; Yi Ting, T.; Ganot, D.; Loh, Y. J.; Nityananda, V.

10.1101/2023.03.30.534907 — animal behavior and cognition — Posted on 2025-04-01

5153 GViNC: An Innovative Framework for Genome Graph Comparison reveals Hidden Patterns in the Genetic Diversity of Human Populations

Kamaraj, V.; Gupta, A.; Raman, K.; Narayanan, M.; Sinha, H.

10.1101/2024.06.10.598220 — genomics — Posted on 2025-04-01

5154 The transcriptome of the mosquito host Anopheles gambiae upon infection by different selected lines of the microsporidian parasite Vavraia culicis

Silva, L. M.

10.1101/2024.09.22.613703 — evolutionary biology — Posted on 2025-04-01

5155 Assessing climate change impacts for small-scale fisheries in the Gulf of California using Deep Learning

Cavieses-Nunez, R.; Lu, Q.; Morzaria-Luna, H. N.; Mallick, P.; Kumara, S.; Navarrete-Torices, C. R.; Cruz-Pinon, G.; Buechler, S.; Lopez-Olmedo, K.

10.1101/2025.03.28.645356 — ecology — Posted on 2025-04-01

5156 SIRT7 links H3K36ac epigenetic regulation with genome maintenance in the aging mouse testis

Guitart-Solanes, A.; Romero, M.; Fernanadez-Duran, I.; Niedenberger, B. A.; Madrid-Sandin, C.; Roig, I.; Geyer, C. B.; Vaquero, A.; Schindler, K.; Vazquez, B. N.

10.1101/2025.03.31.645534 — cell biology — Posted on 2025-04-01

5157 Pseudogymnoascus destructans transcriptional response to chronic copper stress

Anne, S.; McDonald, M. R.; Lu, Y.; Peterson, R. L.

10.1101/2025.03.28.646060 — molecular biology — Posted on 2025-04-01

5158 A non-vesicular Argonaute protein is transmitted from nematode to mouse and is important for parasite survival

Neophytou, K.; Martinez-Ugalde, I.; Fenton, T.; Robertson, E.; Strachan, L. J.; Harcus, Y.; Naar, C. M.; Wright, D.; Price, D. R. G.; White, R.; Evans, M. J.; Bermudez-Barrientos, J. R.; Li, H.; Maizels, R. M.; Aroian, R. V.; Nisbet, A. J.; Abreu-Goodger, C.; Buck, A. H.

10.1101/2025.04.01.646544 — molecular biology — Posted on 2025-04-01

5159 Inherent Specificity and Mutational Sensitivity as Quantitative Metrics for RBP Binding

Yi, S.; Singh, S. S.; Ye, X.; Krishna, R.; Jankowsky, E.; Luna, J. M.

10.1101/2025.03.28.646018 — molecular biology — Posted on 2025-04-01

5160 Active Learning for Protein Structure Prediction

Xue, Z.; Bailey, M.; Gupta, A.; Li, R.; Corrochano-Navarro, A.; Li, S.; Kogler-Anele, L.; Yu, Q.; Bar-Joseph, Z.; Dr. Jager, S.

10.1101/2025.04.01.646404 — molecular biology — Posted on 2025-04-01

5161 Investigating pancreatic beta cell membrane epitopes using unbiased cell-based Fab-phage display

Moursli, Y.; Poitras, C.; Coulombe, B.

10.1101/2025.03.29.645157 — molecular biology — Posted on 2025-04-01

5162 Mechanistic insights into direct DNA and RNA strand transfer and dynamic protein exchange of SSB and RPA

Paul, T.; Lee, I.-R.; Pangeni, S.; Rashid, F.; Yang, O.; Antony, E.; Berger, J. M.; Myong, S.; Ha, T.

10.1101/2025.04.01.643995 — molecular biology — Posted on 2025-04-01

5163 Dairy cattle herds mount a characteristic antibody response to highly pathogenic H5N1 avian influenza viruses

Robinson-McCarthy, L. R.; Simmons, H. C.; Graber, A. L.; Marble, C. N.; Graudin, G. W.; McCarthy, K. R.

10.1101/2025.04.01.646587 — microbiology — Posted on 2025-04-01

5164 Multi-locus phylogenetic network analysis of Ampelomyces mycoparasites isolated from diverse powdery mildews in Australia and the generation of two de novo genome assemblies

Goldspink, L.; Sotiropoulos, A. G.; Idnurm, A.; Ash, G. J.; Dearnaley, J. D. W.; Boddington, M.; Ahmad, A.; Nemeth, M. Z.; Pintye, A.; Gorfer, M.; Shin, H.-D.; Kovacs, G. M.; Vaghefi, N.; Kiss, L.

10.1101/2025.03.31.646484 — microbiology — Posted on 2025-04-01

5165 Iron acquisition in the weevil-farming fungus Penicillium herquei: Implications of mineral elements in insect-fungus mutualistic association

Qiu, P.; Liu, X.; Wei, D.

10.1101/2025.03.31.646393 — microbiology — Posted on 2025-04-01

5166 High-resolution Staphylococcus profiling reveals intra-species diversity in a single skin niche

Herman, R.; West, D. T.; Meaden, S.; Khan, I.; Cornmell, R.; Hunt, J.; Rudden, M.; Wilkinson, H. N.; Hardman, M. J.; Wilkinson, A. J.; Murphy, B.; Thomas, G. H.

10.1101/2025.04.01.646391 — microbiology — Posted on 2025-04-01

5167 Ketamine inhibition of SARS-CoV-2 replication in astrocytes is associated with COVID-19 disease severity in a variant-dependent manner

Furlani, B.; Potokar, M.; Korva, M.; Resman Rus, K.; Pozvek, P.; Zorec, T. M.; Vrsnik, J.; Pirnat, S.; Tavcar Verdev, P.; Smolic, T.; Horvat, A.; Radinovic, K.; Graselli Kmet, N.; Avsic-Zupanc, T.; Vardjan, N.; Stenovec, M.; Jereb, M.; Jorgacevski, J.; Zorec, R.

10.1101/2025.03.29.646083 — neuroscience — Posted on 2025-04-01

5168 MiR-126 Improves the Therapeutic Effect of EPC in Hypertensive Ischemic Stroke

Huang, J.; Zhao, B.; Li, X.; Ding, l.; Fu, M.; Song, Y.; Qu, M.; Chen, D.; Yang, G.-Y.; Gao, P.-J.

10.1101/2025.03.27.645845 — neuroscience — Posted on 2025-04-01

5169 GBM model refinement with literature curation, rule-based NLP, and LLMs

Arazkhani, N.; Luo, H.; Tang, D.; Cochran, B.; Miskov-Zivanov, N.

10.1101/2025.03.27.645730 — systems biology — Posted on 2025-04-01

5170 Transient volume stabilization reveals the key role a PM permeability in pyroptotic cell swelling.

Bastien, E.; Duprez, G.; Delanoë-Ayari, H.; Riviere, C.; Petrilli, V.; Recho, P.; Monnier, S.

10.1101/2025.03.27.645729 — biophysics — Posted on 2025-04-01

5171 Structural defects in amyloid-β fibrils drive secondary nucleation

Hu, J.; Scheidt, T. J.; Thacker, D.; Axell, E.; Stemme, E.; Lapinska, U.; Wennmalm, S.; Meisl, G.; Curk, S.; Andreasen, M.; Vendruscolo, M.; Arosio, P.; Saric, A.; Schmit, J.; Knowles, T.; Sparr, E.; Linse, S.; Michaels, T. C. T.; Dear, A. J.

10.1101/2025.03.31.646415 — biophysics — Posted on 2025-04-01

5172 MotifPeeker: R package for benchmarking epigenomic profiling methods using motif enrichment as a key metric

Dash, H.; Roberts, T.; Weinert, M.; Skene, N.

10.1101/2025.03.31.645756 — bioinformatics — Posted on 2025-04-01

5173 Scalable high-performance single cell data analysis with BPCells

Parks, B.; Greenleaf, W.

10.1101/2025.03.27.645853 — bioinformatics — Posted on 2025-04-01

5174 DeNoFo: a file format and toolkit for standardised, comparable de novo gene annotation

Dohmen, E.; Aubel, M.; Eicholt, L. A.; Roginski, P.; Luria, V.; Karger, A.; Grandchamp, A.

10.1101/2025.03.31.644673 — bioinformatics — Posted on 2025-04-01

5175 Modeling viral and bacterial infections in human lung organotypic systems reveals strain specific host responses

10.1101/2025.03.31.644992 — bioengineering — Posted on 2025-04-01

5176 The Influence of P2O5 on the Structure, Crystallization, and Bioactivity of Silicate-Based Bioactive Glasses and Glass-Ceramics

Soliman, M. G.; El Gohary, M. I.

10.1101/2025.03.30.644796 — bioengineering — Posted on 2025-04-01

5177 An Msp1-Protease Chimera Captures Transient AAA+ Interactions and Unveils Ost4 Mislocalization Errors

Gaur, D.; Acquaviva, B.; Wohlever, M. L.

10.1101/2025.03.31.646376 — biochemistry — Posted on 2025-04-01

5178 Is Hsp110 boosting the basal disaggregation activity Hsp70 by enhanced entropic pulling strokes?

Rebeaud, M. E.; Fauvet, B.; De Los Rios, P.; Goloubinoff, P.

10.1101/2025.04.01.646638 — biochemistry — Posted on 2025-04-01

5179 An Evolutionary Distinct Nipah G Glycosylation Site Provides Stability for Receptor Engagement

Hawkins, T.; Calvaresi, V.; Burnap, S.; Wu, L.; Struwe, W. B.

10.1101/2025.03.31.646399 — biochemistry — Posted on 2025-04-01

5180 Despotism promotes cooperation through enhanced interdependencies in non-human primate societies

Bhattacharjee, D.; Zijlstra, T. W.; Roth, T. S.; Belli, E.; Calis, S. E.; Chova, P. E.; Cousin, E.; de Jong, J. A.; de Laat, E.; Gudjonsdottir, A. R.; Janmaat, K. R. L.; Jeunink, E. J.; Kluiver, C. E.; Kuijer, P. E. N.; Middelburg, E.; Pfluger, L. S.; Schroderus, V. I.; van Dijk, E. S. J.; Verspeek, J.; Waasdorp, S.; Zeeman, A. N.; Sterck, E. H. M.; van Leeuwen, E. J. C.; Massen, J. J. M.

10.1101/2025.03.27.645840 — animal behavior and cognition — Posted on 2025-04-01

5181 Global Metagenomics Reveals Plastid Diversity and Unexplored Algal Lineages

Shrestha, B.; Romero, M. F.; Villada, J. C.; Plastid MAG Consortium, ; Blaby-Haas, C. E.; Schulz, F.

10.1101/2025.03.28.644651 — evolutionary biology — Posted on 2025-04-01

5182 Phylogenomics and macroevolution of a florally diverse Neotropical plant clade (Hillieae)

Ball, L.; Bedoya, A. M.; Taylor, C.; Lagomarsino, L. P.

10.1101/2025.03.29.645733 — evolutionary biology — Posted on 2025-04-01

5183 Disparate estimates of intrinsic productivity for Antarctic krill across small spatial scales, under a rapidly changing ocean.

MARDONES, M.; Jarvis Mason, E.; Santa Cruz, F.; Watters, G.; Cardenas, C.

10.1101/2025.03.27.645857 — ecology — Posted on 2025-04-01

5184 Zone Matcher: A climate-based web application for deployment and assisted migration of forest trees

Shalev, T. J.; McClure, M. L.; Stevenson-Molnar, N.; O'Neill, G. A.; Wang, T.; Stewart, J. A.; Howe, G. T.

10.1101/2025.03.30.644615 — ecology — Posted on 2025-04-01

5185 A NanoBRET-based assay monitoring interactions in the USP18 signaling hub identifies the first cell-penetrant small molecule compromising USP18/ISG15 binding

Hess, S.; Campos-Alonso, M.; Brand, M.; Lauw, S.; Lindenmann, U.; Goebel, K.; Geurink, P. P.; Fritz, G.; Riedl, R.; Knobeloch, K.-P.

10.1101/2025.03.30.646166 — molecular biology — Posted on 2025-04-01

5186 Global transcriptional reprogramming by cytomegalovirus infection suppresses antigen presentation while enhancing migration machinery in murine dendritic cells.

Parry, R. H.; McMillan, C. L. D.; Bruce, K. L.; Farrell, H. E.

10.1101/2025.03.31.646504 — microbiology — Posted on 2025-04-01

5187 Characterization of nitrogenase genes nifP and nifVZT1 in the cyanobacterium Anabaena (Trichormus) variabilis ATCC 29413

Thiel, T.; Pratte, B.; Vernon, S.

10.1101/2025.04.01.646610 — microbiology — Posted on 2025-04-01

5188 Temperature-dependent regulation of bacterial cell division hydrolases by the coordinated action of a regulatory RNA and the ClpXP protease

Mebus, V. H.; Busch, L. M.; Boerre, M.; Nielsen, T. K.; Bojer, M. S.; Henriksen, C.; Barbuti, M. D.; Angeles, D. M.; Brejndal, K.; Michalik, S.; Salazar, M. G.; Kjos, M.; Voelker, U.; Kallipolitis, B. H.; Frees, D.

10.1101/2025.04.01.646552 — microbiology — Posted on 2025-04-01

5189 Rapid Detection of Carbapenemase-Producing Organisms Using a Luminescent Biosensor

Jeffs, M. A.; Bhat, S.; Liu, J. L.; Gray, R. A.; Li, X. X.; Sheth, P. M.; Lohans, C. T.

10.1101/2025.04.01.646590 — microbiology — Posted on 2025-04-01

5190 Itaconate utilisation by the human pathogen Pseudomonas aeruginosa requires uptake via the IctPQM TRAP transporter

Mehboob, J.; Herman, R.; Wilkinson, A. J.; Kinniment-Williams, B. E.; Elston, R. C.; Afolabi, H.; Van der Woude, M. W.; Thomas, G. H.

10.1101/2025.04.01.646390 — microbiology — Posted on 2025-04-01

5191 Impact of acetate on CO2 fixation pathways in thermophilic and hydrogenotrophic bacteria

Chiba, Y.; Sumida, T.; Kameya, M.; Fukuyama, Y.; Wakashima, T.; Shimamura, S.; Kamikawa, R.; Chikaraishi, Y.; Nunoura, T.

10.1101/2025.03.31.646503 — microbiology — Posted on 2025-04-01

5192 Genomic Characterization and New Species Identification of Winogradskyella with Comparative Analysis of Polysaccharide Utilization Loci

Sun, A.-Q.; Deng-Li, J.-Y.; Zhang, H.-Z.; Teng, J.-H.; Du, Z.; Lu, D.-C.

10.1101/2025.03.31.646394 — microbiology — Posted on 2025-04-01

5193 Persisters are primed for CRISPR-Cas adaptation

Mauritzen, J. J.; Wajn, A. S.; Hitz, I. F.; Hoeyland-Kroghsbo, N. M.

10.1101/2025.04.01.646530 — microbiology — Posted on 2025-04-01

5194 Evidence for cPLA2 activation in Alzheimer's Disease Synaptic Pathology

Ma, Q.-L.; Ebright, B.; Li, B.; Li, J.; Galvan, J.; Sanchez, A.; Renteln, M.; Dikeman, D.; Wang, S.; Kerman, B. E.; Seidler, P. M.; Gutierrez-Grebenkova, B.; Hjelm, B. E.; Hawes, D.; Hiniker, A. E.; Hurth, K. M.; Bennett, D. A.; Louie, S. G.; Chui, H. C.; Limon, A.; Arvanitakis, Z.; Yassine, H. N.

10.1101/2025.03.27.645605 — neuroscience — Posted on 2025-04-01

5195 Ethological profiling of pain and analgesia in a mouse model of complex regional pain syndrome.

Muwanga, G. P. B.; Pang, A.; Ewbank, S. N.; Siliezar-Doyle, J.; Nippert, A. R.; Airan, R. D.; Tawfik, V. L.

10.1101/2025.03.28.644648 — neuroscience — Posted on 2025-04-01

5196 Computational Modeling of the Biphasic Depletion of Ovarian Follicle Reserve and the Chemical Effects on Ovarian Aging

Moyd, S. A.; Xiao, S.; Gaskins, A. J.; Zhang, Q.

10.1101/2025.03.27.645815 — systems biology — Posted on 2025-04-01

5197 Secretory stimuli distinctly regulate insulin secretory granule maturation through structural remodeling

Deshmukh, A.; Chang, K.; Cuala, J.; Campos, M. J. H.; Mahmood, S.; Verma, R.; Georgia, S.; Loconte, V.; White, K. L.

10.1101/2025.03.29.644646 — biophysics — Posted on 2025-04-01

5198 Orchestrating multi-state QTL analysis with Bioconductor

Del Azodi, C. B.; Dunstone, A. M.; McCarthy, D. J.

10.1101/2025.03.28.645834 — bioinformatics — Posted on 2025-04-01

5199 Wide visual angle enhances social interaction in a realistic virtual reality environment under simulated artificial vision

Hinrichs, S.; Tisserand, Y.; Scialom, E.; Ghezzi, D.

10.1101/2025.03.27.645647 — bioengineering — Posted on 2025-04-01

5200 The impact of fungal developmental structures on mechanical properties of mycelial materials.

Gray, K. J.; Edwards, H.; Doan, A. G.; Huso, W.; Lee, J.; Pan, W.; Bolima, N.; Gautam, I.; Wang, T.; Srivastava, R.; Zupan, M.; Harris, S.; Marten, M. R.

10.1101/2025.04.01.644731 — bioengineering — Posted on 2025-04-01

5201 Advanced Extracellular Vesicle Isolation: A Hybrid Electrokinetic-Tangential Flow Filtration Approach for Improved Yield, Purity, and Scalability

Kim, Y.; Jeon, S.; Lee, K.; SHIN, S.

10.1101/2025.03.27.645827 — bioengineering — Posted on 2025-04-01

5202 Elevated hydrostatic pressure acts via piezo-1 to destabilise VE-cadherin junctions: an endothelium-on-chip study

Bathrinarayanan, P. V.; Abadie, T.; Esteban, P. P.; Vigolo, D.; Simmons, M. J. H.; Grover, L. M.

10.1101/2025.03.27.645710 — bioengineering — Posted on 2025-04-01

5203 In vivo activation of the dia BGC allows consolidation of the biosynthetic pathways of diaporthin, dichlorodiaporthin, diaporthinic acid, and diaporthinol

10.1101/2025.03.31.646288 — biochemistry — Posted on 2025-04-01

5204 Targeted Protein Degradation by KLHDC2 Ligands Identified by High Throughput Screening

Zhou, H.; Zhou, T.; Yu, W.; Liu, L.; Ko, Y.; Johnson, K. A.; Wilson, I. A.; Schultz, P. G.; Bollong, M. J.

10.1101/2025.03.31.646306 — biochemistry — Posted on 2025-04-01

5205 Cytological and preliminary genomic analysis of two Leptodactylus frog species (Anura, Leptodactylidae) with recently evolved large meiotic rings of multiple X and Y sex chromosomes

Vidal, J. A.; Charlesworth, D.; Ma, W.-J.; Zhou, Q.; Utsunomia, R.; Gomes, A. J.; da Silva, A. B.; Porto-Foresti, F.; Liehr, T.; Cioffi, M. d. B.

10.1101/2025.03.27.645801 — evolutionary biology — Posted on 2025-04-01

5206 Source-sink dynamics explains the co-existence of the invasive pest Dryocosmus kuriphilus and its biological control agent Torymus sinensis across French Eastern Pyrenees.

Zitoun, J.-l.; Rousseau, R.; Gourbiere, S.

10.1101/2025.03.27.645715 — ecology — Posted on 2025-04-01

5207 Multi-scale mitochondrial cristae remodeling links Opa1 downregulation to reduced OXPHOS capacity in aged hearts

Molina-Riquelme, I.; Barrientos, G.; Breitsprecher, L.; Gomez, W.; Diaz-Castro, F.; Morris, S.; del Campo, A.; Garrido-Olivares, L.; Verdejo, H.; Psathaki, O. E.; Busch, K. B.; Eisner, V.

10.1101/2025.04.01.644555 — cell biology — Posted on 2025-04-01

5208 An acyclic nucleoside phosphonate effectively blocks the egress of the malaria parasite by inhibiting the synthesis of cyclic GMP.

Ali, M.; Dura, R.; Guery, M.-A.; Colard-Itte, E.; Cheviet, T.; Robresco, L.; Berry, L.; Lionne, C.; Lavazec, C.; Claessens, A.; Peyrottes, S.; Wengelnik, K.; Wein, S.; Cerdan, R.

10.1101/2025.04.01.645218 — microbiology — Posted on 2025-04-01

5209 Energy calculations for atomic oxygen liberation from hypohalous acids biosynthesized by mammalian peroxidases

Puf, R.; Smith, M. L.; Laaksonen, A.

10.1101/2025.03.27.645784 — immunology — Posted on 2025-04-01

5210 Age-associated inflammatory monocytes are increased in menopausal females and reversed by Hormone Replacement Therapy

De Maeyer, R. P.; Sikora, J.; Bracken, O. V.; Shih, B. B.-J.; Lloyd, A. F.; Peckham, H. F.; Hollett, K.; Abdelhamid, K.; Cai, W.; James, M.; Pfeffer, P. E.; Vukmanovic-Stejic, M.; Akbar, A. N.; Chambers, E. S.

10.1101/2025.03.28.645904 — immunology — Posted on 2025-04-01

5211 Sex-specific proteomic analysis of epileptic brain tissues from Pten knockout mice and human refractory epilepsy

Li, Y.; Sadri, Z.; Blandin, K. J.; Narvaiz, D. A.; Aryal, U. K.; Lugo, J. N.; Poolos, N. P.; Brewster, A. L.

10.1101/2025.03.27.645753 — neuroscience — Posted on 2025-04-01

5212 Kinetic organization of the genome revealed by ultra-resolution, multiscale live imaging

Lee, J.; Chen, L.-F.; Gaudin, S.; Gupta, K.; Spakowitz, A.; Boettiger, A.

10.1101/2025.03.27.645817 — biophysics — Posted on 2025-04-01

5213 "Visualize, describe, compare" - nanoinformatics approaches for material-omics

Izquierdo-Lozano, C.; Tholen, M. M. E.; Girola, V.; Swietlikowska, A.; Merkx, M.; Grisoni, F.; Albertazzi, L.

10.1101/2025.03.27.645714 — bioinformatics — Posted on 2025-04-01

5214 Scalable, high-throughput isolation of extracellular vesicles using electrokinetic-assisted mesh filtration

Lee, K.; Bae, M.; Kim, Y.; Jeon, S.; Kang, S.; Rhee, W.; SHIN, S.

10.1101/2025.03.27.645682 — bioengineering — Posted on 2025-04-01

5215 CRISPR/Cas9-mediated editing of the ADE2 locus in Saccharomyces cerevisiae: targeted mutagenesis and homology-directed repair

JARRA, E.

10.1101/2025.03.30.646154 — genomics — Posted on 2025-04-01

5216 Disentangling the impact of abiotic and biotic environmental factors and dispersal dynamics on bacterial pangenome fluidity

Goh, Y.-X.; Hardeep, F.; Zhang, H.; Liao, J.

10.1101/2025.03.27.645760 — genomics — Posted on 2025-04-01

5217 Phylogenetics, evolution and biogeography of four Digitaria food crop lineages across West Africa, India, and Europe

Burton, G. P.; Ceci, P.; MacKinnon, L.; Masters, L.; Ryan, P.; Turnbull, C.; Ulian, T.; Vorontsova, M. S.

10.1101/2025.03.27.645812 — genetics — Posted on 2025-04-01

5218 Evolution of division of labor on two public goods with continuous investments

Fielding, A.; Akcay, E.; Plotkin, J. B.

10.1101/2025.03.27.645589 — evolutionary biology — Posted on 2025-04-01

5219 Effects of amendments on remediation of heavy metal contaminated soil and accumulation of Cd and Pb in potato

He, R.; Liu, K.; Yang, F.; Feng, S.; Zhang, L.

10.1101/2025.03.30.646218 — ecology — Posted on 2025-04-01

5220 Chimeric anti-HLA antibody receptor engineered human regulatory T cells suppress alloantigen-specific B cells from pre-sensitized transplant recipients

Valentin-Quiroga, J.; Zarauza-Santovena, A.; Lopez-Collazo, E.; Ferreira, L. M. R.

10.1101/2025.03.27.645777 — immunology — Posted on 2025-04-01

5221 Natural spider silk enhances mechanical performance of collagen scaffold under stretching conditions

Tso, I.-M.; Tsiareshyna, M.; Huang, S. Y. T.; Liao, C.-P.; Tang, M.-J.; Wong, T.-Y.

10.1101/2025.03.27.645864 — zoology — Posted on 2025-04-01

5222 Non-destructive monitoring of tissue-specific, irrigation responsive impedance signals in leaves using microneedles probes

Read, K. J. H.; Hudson, P. J.; Monclova, J.; Monteith, H.; Polsky, R.; Seitz, K.; Hanson, D. T.; Miller, P. R.

10.1101/2025.03.31.646420 — plant biology — Posted on 2025-04-01

5223 Obesity and sarcopenia affect the metabolite profiles of pet dogs

Elo, C.; Kaimio, M.; Leminen, E.; Lohi, H.

10.1101/2025.03.31.645884 — physiology — Posted on 2025-04-01

5224 The BK channel-NS1619 agonist complex reveals molecular insights on allosteric activation gating

Gonzalez-Sanabria, N.; Contreras, G. F.; Rojas, M.; Duarte, Y.; Gonzalez-Nilo, F. D.; Perozo, E.; Latorre, R.

10.1101/2025.03.27.645783 — biophysics — Posted on 2025-04-01

5225 In-solution Characterization of Biomolecular Interaction Kinetics under Native Conditions

Willmer, P.; Stender, E. G.; Ray, K. S.; Hundahl, A. C.; Marie, R.; Jensen, H.

10.1101/2025.03.27.645748 — biophysics — Posted on 2025-04-01

5226 Machine Learning-Based Identification of Survival-Associated CpG Biomarkers in Pancreatic Ductal Adenocarcinoma

Zhang, B.; Zhang, Y.; Zhao, Y.

10.1101/2025.03.29.646090 — bioinformatics — Posted on 2025-04-01

5227 GeneWhisperer: Enhancing manual genome annotation with large language models

Li, X.; Whan, A. P.; McNeil, M.; Andrew, S. C.; Dai, X.; Fechner, M.; Paris, C.; Suchecki, R.

10.1101/2025.03.30.646211 — bioinformatics — Posted on 2025-04-01

5228 Influence of enclosure design on the behaviour and welfare of Pogona vitticeps

Denomme, M.; Bakker, N. L.; Tattersall, G. J.

10.1101/2025.03.27.645862 — animal behavior and cognition — Posted on 2025-04-01

5229 Functional profiling of KCNE1 variants informs population carrier frequency of Jervell and Lange-Nielsen syndrome type 2

Vanoye, C. G.; Desai, R. R.; John, J.; Hoffman, S.; Fink, N.; Zhang, Y.; Venkatesh, O.; Roe, J.; Adusumilli, S.; Jairam, N.; Sanders, C.; Gordon, A.; George, A. L.

10.1101/2025.03.28.646046 — genetics — Posted on 2025-04-01

5230 Surveillance of Japanese Encephalitis Virus in Piggery Effluent and Environmental Samples: A Complementary Tool for Outbreak Detection

Ahmed, W.; Gebrewold, M.; Williams, D. T.; Wang, J.; Smith, W.; Starick, L. G.; Fogarty, R. M.; Richards, K.; Simpson, S.

10.1101/2025.03.27.645166 — molecular biology — Posted on 2025-04-01

5231 Archaeological Bolivian maize genomes suggest Inca cultural expansion augmented maize diversity in South America

Chen, H.; Baetsen-Young, A.; Thompson, A.; Day, B.; Madzima, T.; Wasef, S.; Rivera Casanovas, C.; Lovis, W.; Wrobel, G.

10.1101/2025.03.31.646424 — plant biology — Posted on 2025-04-01

5232 Developing the Grapevine Hydric Stress Atlas: A Meta-Analysis Resource for Exploring transcriptome Responses to Drought

VALENZUELA, A. V.; Navarro-Paya, D.; Santiago, A.; Sonego, P.; Gainza-Cortes, F.; Malnoy, M.; Matus, J. T.

10.1101/2025.03.31.646369 — plant biology — Posted on 2025-04-01

5233 Effect of membrane composition on interaction and permeation of a mycobacterial siderophore

Sharifian, F.; Ebrahimi, M.; Mehdipour, A. R.

10.1101/2025.03.27.645699 — biophysics — Posted on 2025-04-01

5234 Simulated metabolic profiles reveal biases in pathway analysis methods

Cooke, J.; Wieder, C.; Poupin, N.; Frainay, C.; Ebbels, T.; Jourdan, F.

10.1101/2025.03.27.645696 — bioinformatics — Posted on 2025-04-01

5235 MKFGO: Integrating Multi-Source Knowledge Fusion with Pre-Trained Language Model for High-Accuracy Protein Function Prediction

Zhu, Y.-H.; Zhu, S.; Yu, X.; Yan, H.; Liu, Y.; Xie, X.; Yu, D.-J.; Ye, R.

10.1101/2025.03.27.645685 — bioinformatics — Posted on 2025-04-01

5236 A differentiated and durable allogeneic strategy applicable to cell therapies

Jetley, U.; Balwani, I.; Sharma, P.; Miller, I.; Luther, A.; Dutta, I.; Saravanan, N.; Zhang, Q.; Zhang, B.; Kilic, O.; Liu, B.; Han, B. W.; Liu, D.; Schultes, B.; Prodeus, A.; Zhang, Y.

10.1101/2025.03.27.645807 — bioengineering — Posted on 2025-04-01

5237 Expression, purification and preliminary pharmacological characterization of the Plasmodium falciparum membrane-bound pyrophosphatase type 1

Liu, J.; Vidilaseris, K.; Johansson, N. G.; Ribeiro, O.; Dreano, L.; Yli-Kauhaluoma, J.; Xhaard, H.; Goldman, A.

10.1101/2025.03.30.646216 — biochemistry — Posted on 2025-04-01

5238 Biosynthesis of modular signaling molecules requires functional diversification of carboxylesterases in Pristionchus pacificus

Dong, C.; Zhang, P.; Theam, P.; Xu, W.; Ye, S.; Witte, H.; Liu, T.; Sommer, R. J.

10.1101/2025.03.28.645926 — biochemistry — Posted on 2025-04-01

5239 BioToken and BioFM - Biologically-Informed Tokenization Enables Accurate and Efficient Genomic Foundation Models

Medvedev, A.; Viswanathan, K.; Kanithi, P.; Vishniakov, K.; Munjal, P.; Christophe, C.; Pimentel, M. A.; Rajan, R.; Khan, S.

10.1101/2025.03.27.645711 — genomics — Posted on 2025-04-01

5240 Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity

Meade, R. K.; Adefisayo, O. O.; Gontijo, M. T. P.; Harris, S. J.; Pyle, C. J.; Wilburn, K. M.; Ecker, A. M. V.; Hughes, E. J.; Garcia, P. D.; Ivie, J.; McHenry, M. L.; Benchek, P. H.; Mayanja-Kizza, H.; Neff, J. L.; Ko, D. C.; Stout, J. E.; Stein, C. M.; Hawn, T. R.; Tobin, D. M.; Smith, C. M.

10.1101/2025.04.01.644622 — genetics — Posted on 2025-04-01

5241 Filamentous cheater phages drive bacterial and phage populations to lower fitness

Kubota, N. S.; Scribner, M. R.; Cooper, V. S.

10.1101/2025.04.01.646652 — microbiology — Posted on 2025-04-01

5242 CELF2 suppresses endogenous RNA ligands that activate RIG-I-mediated interferon induction

Smith, J. R.; Kern, O. C.; Mishra, G.; Gokhale, N. S.; Etzyon, N.; Somfleth, K.; Schwerk, J.; Nakamichi, K.; Pugliano, C. M.; Lindbloom-Brown, Z.; Gale, M.; Savan, R.

10.1101/2025.03.27.645787 — immunology — Posted on 2025-04-01

5243 Preferred spatial frequency covaries with cortical magnification in human primary visual cortex

Himmelberg, M. M.; Kwak, Y. M.; Carrasco, M.; Winawer, J.

10.1101/2025.03.19.644195 — neuroscience — Posted on 2025-04-01

5244 TARP γ-8 is a target of ethanol that regulates self-administration and relapse in mice

Faccidomo, S.; Hoffman, J. L.; Lee, J.; Whindleton, C. M.; Kim, M.; Taylor, S.; Kim, A.; Richter, C.; Seiters, H.; Bryant, J.; Chang, A.; Smith, E.; Agoglia, A. E.; Tomita, S.; Herman, M. A.; Hodge, C. W.

10.1101/2025.03.27.645788 — neuroscience — Posted on 2025-04-01

5245 Evidence for active regulation of transpiration in non-stomatal plants

Perera-Castro, A. V.; Marquez, D. A.; Busch, F. A.; Hanson, D.

10.1101/2025.04.01.646543 — plant biology — Posted on 2025-04-01

5246 Faster relaxation of nonphotochemical quenching (NPQ) in C4 than in C3 species

Cubas, L. A.; Nakamura, A.; Vath, R. L.; Rodrigues Gabriel Sales, C.; Bernardo, E. L.; Munekage, Y.; Kromdijk, J.

10.1101/2025.04.01.646649 — plant biology — Posted on 2025-04-01

5247 Xylan modifications in Populus that lead to increased growth

Urbancsok, J.; Donev, E. N.; Derba-Maceluch, M.; Sivan, P.; Barbut, F. R.; Mitra, M.; Yassin, Z.; Cermanova, K.; Simura, J.; Karady, M.; Scheepers, G.; Mellerowicz, E. J.

10.1101/2025.03.31.646328 — plant biology — Posted on 2025-04-01

5248 With or without a Ca2+ signal;A proteomics approach towards Ca2+ dependent and independent proteome changes in response to oxidative stress in A. thaliana

van Dieren, A. v.; Bittner, A.; Wurzinger, B.; Afjehi-Sadat, L.; Weckwerth, W.; Teige, M.; Vothknecht, U. C.

10.1101/2025.03.31.645912 — plant biology — Posted on 2025-04-01

5249 Genetic architecture of the S-locus supergene revealed in a tetraploid distylous species

Luo, Z.; Barrett, S. C. H.; Tu, T.; Zhao, Z.; Jia, S.; Gu, S.; Duan, T.; Zhang, Y.; Xu, B.; Gu, L.; Jiang, L.; Deng, X.; Shi, M.; Zhang, D.

10.1101/2025.04.01.646584 — plant biology — Posted on 2025-04-01

5250 Impact of the introgression of resistance loci on agro-oenological traits in grapevine interspecific hybrids

Chedid, E.; Rustenholz, C.; Avia, K.; Dumas, V.; Merdinoglu, D.; Duchene, E.

10.1101/2025.03.31.646340 — plant biology — Posted on 2025-04-01

5251 A multi-modal cell-free RNA language model for liquid biopsy applications

Karimzadeh, M.; Sababi, A. M.; Momen-Roknabadi, A.; Chen, N.-C.; Cavazos, T. B.; Sekhon, S.; Wang, J.; Hanna, R.; Huang, A.; Nguyen, D.; Chen, S.; Lam, T.; Hartwig, A.; Fish, L.; Li, H.; Behsaz, B.; Hormozdiari, F.; Alipanahi, B.; Goodarzi, H.

10.1101/2025.03.26.645557 — bioinformatics — Posted on 2025-04-01

5252 Native Top-Down Proteomics of Endogenous Protein Complexes Enabled by Online Two-Dimensional Liquid Chromatography

Fischer, M. S.; Rogers, H. T.; Chapman, E. A.; Jin, S.; Ge, Y.

10.1101/2025.03.28.645965 — biochemistry — Posted on 2025-04-01

5253 Highly pathogenic avian influenza management in high-density poultry farming areas

Guinat, C.; Valuenzuela Agui, C.; Briand, F.-X.; Chakraborty, D.; Fourtune, L.; Lambert, S.; Jimenez Pellicer, A.; Rautureau, S.; Gerbier, G.; du Plessis, L.; Stadler, T.; Grasland, B.; Paul, M.; Vergne, T.

10.1101/2025.03.25.645233 — evolutionary biology — Posted on 2025-04-01

5254 Pseudomonas aeruginosa MucP contributes to RNA phage resistance by targeting phage lysis

Bae, H.-W.; Kim, S.-Y.; Choi, S.-Y.; Ki, H.-J.; Ahn, S.-J.; Cho, Y.-H.

10.1101/2024.12.09.627492 — microbiology — Posted on 2025-04-01

5255 Photoperiodic Regulation of SK Channels in Dorsal Raphe Serotonin Neurons

Giannoni Guzman, M. A.; Zepeda, J. C.; Kamitakahara, A.; Magalong, V.; Levitt, P.; Grueter, B.; McMahon, D. G.

10.1101/2025.03.29.646123 — neuroscience — Posted on 2025-04-01

5256 Brain structural modules associated to functional high-order interactions in the human brain

Camino-Pontes, B.; Jimenez-Marin, A.; Tellaetxe-Elorriaga, I.; Fernandez-Iriondo, I.; Erramuzpe, A.; Diez, I.; Bonifazi, P.; Gatica, M.; Rosas, F. E.; Marinazzo, D.; Stramaglia, S.; Cortes, J.

10.1101/2025.03.21.644509 — neuroscience — Posted on 2025-04-01

5257 Real-time tracking of intracellular prenyl phosphate pools in the marine diatom Phaeodactylum tricornutum with a metabolite protein-based biosensor

Patwari, P.; Moses, T.; Fabris, M.

10.1101/2025.03.31.646338 — synthetic biology — Posted on 2025-04-01

5258 Machine learning-assisted enzyme engineering through ultra-high throughput sorting and large-scale sequence-function data generation

Zhang, J.; Shanmugam, S.; Yeoh, J. W.; Zheng, D.; Goh, J. R.; Lin, Z.; Poh, C. L.

10.1101/2025.03.30.645636 — synthetic biology — Posted on 2025-04-01

5259 Enhancing the efficacy, utility and throughput of the Transcription Block Survival peptide library screening platform

Brennan, A.; Tang, T. M. S.; Mason, J. M.

10.1101/2025.03.28.645970 — synthetic biology — Posted on 2025-04-01

5260 Automatic feedback control for resource-aware characterisation of genetic circuits

Sechkar, K.; Steel, H.

10.1101/2025.04.01.646303 — synthetic biology — Posted on 2025-04-01

5261 Leafy liverwort genomes shed light on the evolution of ericoid symbiosis

Castanedo, L.; Bianconi, M.; Pellen, T.; Vernie, T.; Lefort, C.; Libourel, C.; Le Ru, A.; Rodde, N.; Cauet, S.; Callot, C.; Forrest, L.; Nishiyama, T.; Wickell, D.; Li, F.-W.; Keller, J.; Delaux, P.-M.

10.1101/2025.04.01.646537 — plant biology — Posted on 2025-04-01

5262 Evolutionary Trade-off Between Stomatal Defense and Gas Exchange in Brassicaceae

Kang, W.; Nakano, M.; Fukumoto, K.; Hirata, R.; Zhai, P.; Du, Y.; Hong, K.; Ziegler, J.; Tsuda, Y.; Becker, D.; Nambara, E.; Nakano, R. T.; Miyashima, S.; Mine, A.; Han, X.; Tsuda, K.

10.1101/2025.03.31.646295 — plant biology — Posted on 2025-04-01

5263 CDK12 condensation in nuclear speckles confers sensitivity to cyclin K molecular glue degraders

Ye, K.; He, Q.; Cheng, Y.; Zhang, M.; Mu, H.; Cai, M.-C.; Zhou, S.; Xiang, H.; Hou, Y.; Li, Y.; Zang, Y.; Lv, J.; Cheng, L.; Xiang, L.; Zhao, D.; Zhang, Y.; Li, Y.; Yin, X.; Di, W.; Shen, P.; Zhuang, G.; Tan, L.

10.1101/2025.03.31.646293 — cancer biology — Posted on 2025-04-01

5264 FMO4 drives lung adenocarcinoma by stabilizing the MAT2A/MAT2B complex and hindering ferroptosis

Bracquemond, D.; Mahdizadeh, S. J.; Brunet, L.; Thomas, Q. D.; Bouclier, C.; Colomb, M.; Bourdel, S.; Fabbrizio, E.; Tourriere, H.; Papon, L.; Quantin, X.; Santos, A.; Ferrer, I.; Henry, S.; Grosgeorges, M.; Perna, V.; Lozano, M. D.; Solorzano, J. L.; Bossowski, J. P.; Papagiannakopoulos, T.; Tiseo, M.; Minari, R.; Turtoi, A.; Mange, A.; Montuenga, L. M.; Paz-Ares, L.; Faget, j.; Eriksson, L. A.; Mancini, M.; Maraver, A.

10.1101/2025.03.31.646284 — cancer biology — Posted on 2025-04-01

5265 Molecular dynamics of membrane partitioning of nifedipine prior to binding calcium channel Cav1.1

Dhondt, W.; Vanduyfhuys, L.; Mehdipour, A. R.

10.1101/2025.03.27.645691 — biophysics — Posted on 2025-04-01

5266 Assessing variant effect predictors and disease mechanisms in intrinsically disordered proteins

Fawzy, M.; Marsh, J. A.

10.1101/2025.04.01.646619 — bioinformatics — Posted on 2025-04-01

5267 DNA origami directed nanometer-scale integration of colloidal quantum emitters with silicon photonics

Luo, X.; Ranno, L.; Sverko, T.; Lee, J. Y.; Sbalbi, N.; Jones, A.; Chen, C.; Bawendi, M. G.; Hu, J.; Macfarlane, R. J.; Bathe, M.

10.1101/2025.01.23.634416 — bioengineering — Posted on 2025-04-01

5268 Mapping affinity and allostery in human IgG antibody Fc region-Fc γ receptor interactions

Keith, A.; Xu, T.; Chernova, T.; Keen, M.; Bogacz, M.; Nedeljkovic, M.; Flowers, M.; Brown, T.; Frank, F.; Ortlund, E. A.; Sundberg, E.

10.1101/2025.03.28.645945 — biochemistry — Posted on 2025-04-01

5269 NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT

Wu, Z.; Nguyen, P. T.; Sondhi, V.; Yao, R.-W.; Dai, T.; Chiang, J.-C.; Shang, Z.; Cai, F.; Zhang, J.; Moore, M. D.; Alshamleh, I.; Li, X.; Ogu, T.; Zacharias, L. G.; Winston, R.; Patricio, J. S.; Johnson, X.; Chen, W.-M.; Cong, Q.; Mathews, T. P.; Zhang, Y.; DeBerardinis, R. J.

10.1101/2025.03.29.646096 — biochemistry — Posted on 2025-04-01

5270 Smoothened inhibition of PKA at cilia transduces Hedgehog signals

Nguyen, T. D.; Konjikusic, M. J.; Castillo, L. D.; Reiter, J. F.

10.1101/2025.04.01.646243 — biochemistry — Posted on 2025-04-01

5271 Illuminating the mystery of thylacine extinction: a role for relaxed selection and gene loss

Salve, B. G.; Vijay, N.

10.1101/2025.03.27.645633 — genomics — Posted on 2025-04-01

5272 Identification of genetic and non-genetic modifiers of genomic imprinting through whole genome screening in humans

Cecere, F.; Relator, R.; Levy, M.; Verma, A.; McConkey, H.; Hay Mele, B.; Pignata, L.; Giaccari, C.; D'Angelo, E.; Saha, S.; Saadat, A.; Sparago, A.; Angelini, C.; Cerrato, F.; Sadikovic, B.; Riccio, A.

10.1101/2025.03.27.645693 — genetics — Posted on 2025-04-01

5273 Influenza A virus RNA Polymerase targets the chromatin of innate immune response genes

YI, J.; MOREL, J.; COSTALLAT, M.; LEJAL, N.; DELMAS, B.; MUCHARDT, C.; Batsche, E.

10.1101/2022.03.30.486363 — molecular biology — Posted on 2025-04-01

5274 Virtual Screening for the Discovery of Novel Urease Inhibitors Targeting Rumen Bacterial Urease

Zhao, S.; Ilina, L.

10.1101/2022.08.16.504210 — microbiology — Posted on 2025-04-01

5275 Vaccine-induced and hybrid immunity against SARS-CoV-2 variants of concern in two cohorts in Queensland, Australia (2021-2022).

Parry, R. H.; Shang, Y. H.; Sng, J. D. J.; McMillan, C. L. D.; Modhiran, N.; Amarilla, A. A.; Isaacs, A.; Liang, B.; Muller, D. A.; Rawle, D. J.; Suhrbier, A.; Anderson, S.; Kelly, S.; Watterson, D.; Burr, L.; Khromykh, A.

10.1101/2024.11.11.623100 — microbiology — Posted on 2025-04-01

5276 Temporal Propagation of Neural State Boundaries in Naturalistic Context

Oetringer, D.; Henderson, S.; Gözükara, D.; Geerligs, L.

10.1101/2025.02.28.640737 — neuroscience — Posted on 2025-04-01

5277 Early-life stress alters chromatin modifications in VTA to prime stress sensitivity

Geiger, L. T.; Balouek, J.-A. R.; Barrett, M. R.; Thompson, J. M.; Fang, L. Z.; Farrelly, L. A.; Chen, A. S.; Tang, M.; Bennett, S. N.; Garcia, B. A.; Maze, I.; Creed, M. C.; Pena, C. J.

10.1101/2024.03.14.584631 — neuroscience — Posted on 2025-04-01

5278 Unraveling the mesoscale functional connectivity of the human primary visual cortex using high-resolution functional MRI.

Schmidt, M. E.; Aganj, I.; Stockmann, J.; Bilgic, B.; Chang, Y.; Hoge, W. S.; Kirilina, E.; Weiskopf, N.; Nasr, S.

10.1101/2025.03.27.645795 — neuroscience — Posted on 2025-04-01

5279 Adapt-A-Maze: An Open Source Adaptable and Automated Rodent Behavior Maze System

Porter, B. S.; Olson, J. M.; Leppla, C. A.; Duvelle, E.; Bladon, J. H.; van der Meer, M. A.; Jadhav, S. P.

10.1101/2021.06.05.447225 — neuroscience — Posted on 2025-04-01

5280 Population responses in V1 encodes stimulus visibility in backward masking

Dennis, I. T.; Edelman-Klapper, H.; Gadi-Raveh, G.; Bar-Shira, O.; Margalit, S. N.; Slovin, H.

10.1101/2025.03.30.642841 — neuroscience — Posted on 2025-04-01

5281 The ultrastructural properties of the endoplasmic reticulum govern microdomain signaling in perisynaptic astrocytic processes

Denizot, A.; Castillo, M. F. V.; Puchenkov, P.; Cali, C.; De Schutter, E.

10.1101/2022.02.28.482292 — neuroscience — Posted on 2025-04-01

5282 Combining quantum cascade lasers and plasmonic metasurfaces to monitor de novo lipogenesis with vibrational contrast microscopy

Huang, S. H.; Tulegenov, D.; Shvets, G.

10.1101/2025.03.30.646207 — cell biology — Posted on 2025-04-01

5283 Shapes and Dimensions of Blood Clots Affect the Rate and Extent of Platelet-Driven Clot Contraction and Will Determine the Outcomes of Thrombosis

Khismatullin, R. R.; Khabirova, A. I.; Saliakhutdinova, S. M.; Litvinov, R. I.; Weisel, J. W.

10.1101/2025.03.30.646236 — cell biology — Posted on 2025-04-01

5284 A Versatile and Open Source One- and Two-Photon Light-Sheet Microscope Design

Hubert, A.; Panier, T.; Migault, G.; Trentesaux, H.; Beaudou, B.; Debregeas, G.; Bormuth, V.

10.1101/2023.07.10.548107 — neuroscience — Posted on 2025-04-01

5285 AT1R and Integrin β3 Synergize to Drive Aortic Dissection via Non-Canonical Wnt/β-Catenin Signaling

Jang, H.; Liu, Z.; Li, Y.; Zhong, X.; Qu, Y.; Li, S.; Dai, L.; Zhang, Y.; Wang, M.; Zhang, W.; Liu, W.; He, X.; Dong, W.; Madhusudhan, T.; Li, Z.; Wang, H.; Zeng, H.

10.1101/2025.03.26.645618 — pharmacology and toxicology — Posted on 2025-04-01

5286 Advancing RNAi-Based Strategies Against Downy Mildews: Insights Into dsRNA Uptake and Gene Silencing

Gol, D.; Okechukwu, E. C.; Unal, G.; Webb, A.; Wood, T.; Hong, Y.; Sherif, S.; Wacker, T.; Studholme, D. J.; McDowell, J.; Tor, M.

10.1101/2025.03.31.646348 — plant biology — Posted on 2025-04-01

5287 Polyphenol oxidase silencing avoids protein crosslinking and enzymatic browning in Nicotiana benthamiana leaf extracts

Mahadevan, C.; Watts, E. C.; Zheng, K.; Song, S.-j.; van der Hoorn, R. A. L.

10.1101/2025.03.31.646341 — plant biology — Posted on 2025-04-01

5288 PCNA encircling primer/template junctions is eliminated by exchange of RPA for Rad51: Implications for the interplay between human DNA damage tolerance pathways

Hedglin, M.; Norris, J.; Rogers, L. O.; Young, G.; Pytko, K. G.; Dannenberg, R. L.; Perreault, S.; Kaushik, V.; Antony, E.

10.1101/2025.03.27.645792 — biophysics — Posted on 2025-04-01

5289 mcDETECT: Decoding 3D Spatial Synaptic Transcriptomes with Subcellular-Resolution Spatial Transcriptomics

Yuan, C.; Patel, K.; Shi, H.; Wang, H.-L.; Wang, F.; Li, R.; Li, Y.; Corces, V.; Shi, H.; Das, S.; Yu, J.; Jin, P.; Yao, B.; Hu, J.

10.1101/2025.03.27.645744 — bioinformatics — Posted on 2025-04-01

5290 Trypanosoma cruzi Has 32 Chromosomes: A Telomere-to-Telomere Assembly Defines Its Karyotype.

Greif, G.; Diaz-Viraque, F.; Chiribao, M. L.; Sanz-Rodriguez, C.; Robello, C.

10.1101/2025.03.27.645724 — genomics — Posted on 2025-04-01

5291 Distal Gene Expression Governed by Lamins and Nesprins via Chromatin Conformation Change

Zhang, H.; Lei, Z.; Momen-Heravi, F.; Qin, P.

10.1101/2025.04.01.646570 — cell biology — Posted on 2025-04-01

5292 Senescent cell survival relies on upregulation of lysosomal quality control mechanisms

Carroll, B.; Curnock, R.

10.1101/2025.03.31.646397 — cell biology — Posted on 2025-04-01

5293 Microtubule acetylation is a biomarker of cytoplasmic health during cellular senescence

Shen, Y.; Maxson, R.; McKenney, R. J.; Ori-McKenney, K. M.

10.1101/2025.03.31.646469 — cell biology — Posted on 2025-04-01

5294 Mitochondrial function regulates cell growth kinetics to actively maintain mitochondrial homeostasis

Chacko, L. A.; Nakaoka, H.; Morris, R. G.; Marshall, W.; Ananthanarayanan, V.

10.1101/2025.03.31.646474 — cell biology — Posted on 2025-04-01

5295 Sirtuin 2 controls global protein synthesis by regulating Rheb-GTPase

Shrama, A.; Zi, Y.; Pandit, A. S.; Jha, K.; Sinha, V. K.; Ravi, V.; Ghosh, S.; Nagesh, D.; Shivanaiah, B.; Khan, D.; Prabhashankar, A. B.; Sumi, T. S.; Raghu, S.; Srivastava, A.; Singh, M.; Lin, H.; Sundaresan, N. R.

10.1101/2025.03.31.646364 — cell biology — Posted on 2025-04-01

5296 Differential cell survival outcomes in response to diverseamino acid stress

Murray, P. J.; Russier, M.; Fiore, A.; Gross, A.; Tanzer, M.; Yeroslaviz, A.; Mann, M.

10.1101/2025.04.01.646536 — cell biology — Posted on 2025-04-01

5297 Impact of Serum Circulating Factors and PDE5 Inhibitor Therapy on Cardiomyocyte Metabolism in Single Ventricle Heart Disease

Garcia, A. M.; Pietra, A. E.; Turner, M. E.; Pires Da Silva, J.; Baybayon-Grandgeorge, A. N.; Sparagna, G. C.; Jeffrey, D. A.; Stauffer, B. L.; Sucharov, C. C.; Miyamoto, S. D.

10.1101/2025.03.31.646497 — cell biology — Posted on 2025-04-01

5298 SIRT2 Mediates Integrated Stress Response by Deacetylating and Stabilizing 4EBP1 to Suppress Translation

Zi, Y.; Wang, M.; Hou, D.; Cerione, R. A.; Lin, H.

10.1101/2025.03.31.646365 — cell biology — Posted on 2025-04-01

5299 Lack of evidence for cargo release of CD63-EVs into recipient cells

Askarian-Amiri, S.; Weissenhorn, W.; Sadoul, R.; Chatellard, C.

10.1101/2025.04.01.646561 — cell biology — Posted on 2025-04-01

5300 Single Nucleus Multiome Analysis Reveals Early Inflammatory Response to High-Fat Diet in Mouse Pancreatic Islets

Ernst, I. V. S.; Lehtonen, L.; Nilsson, S. M.; Nielsen, F. L.; Marcher, A.-B.; Mandrup, S.; Madsen, J. G. S.

10.1101/2025.04.01.646568 — cell biology — Posted on 2025-04-01

5301 Tracing Early Migratory Neurons in the Developing Nose Using Contactin-2 (Cntn2)CreERT2

Amato, E.; Semon, A. M.; Forni, P. E.

10.1101/2025.03.27.645843 — neuroscience — Posted on 2025-04-01

5302 Cytokine-driven cellular polarization in preeclampsia revealed through the "Dictionary of immune responses"

Wan, S.; Zhou, T.; Ma, Y.; Chen, Y.; Zhou, C. C.; Peng, J.; Lin, L.; Luo, W.; Gu, W.; Liu, Z.; Hua, X.

10.1101/2025.03.26.645616 — bioinformatics — Posted on 2025-04-01

5303 Mapping Histoplasma in Bats and Cave Ecosystems: Evidence from Midwestern Brazil

Bernardes, J. P. R. A.; Tenorio, B. G.; Lucas, J. M.; Paternina, C. E. M.; Silva, R. K. M.; Erazo, F. A. H.; Silva-Pereira, I.; Alves, L. G. d. B.; Arenas, P. H. R.; Bueno-Rocha, I. D.; Magalhaes, E. D.; de Sousa, H. R.; Paes, H.; Zancope-Oliveira, R. M.; Matute, D. R.; Felipe, M. S. S.; Aguiar, L. M. d. S.; Charneau, S. O.; Nicola, A. M.; Teixeira, M. d. M.

10.1101/2025.03.31.641930 — microbiology — Posted on 2025-04-01

5304 Macrophages maintain signaling fidelity in response to ligand mixtures

Guo, X.; Sen, S.; Gonzalez, J.; Hoffmann, A.

10.1101/2025.03.27.645368 — systems biology — Posted on 2025-04-01

5305 Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially control regulatory T cell phenotype and function via CXCL9 and CCL22

Maru, S. Y.; Wetzel, M.; Mitchell, J. T.; Gross, N. E.; Andaloori, L.; Howe, K.; Kartalia, E.; Mo, G.; Leatherman, J.; Ho, W. J.; Fertig, E. J.; Kagohara, L. T.; Pearce, E. J.; Jaffee, E. M.

10.1101/2025.03.27.645833 — cancer biology — Posted on 2025-04-01

5306 Spatial Analysis of Malignant-Immune Cell Interactions in the Tumor Microenvironment Using Topological Data Analysis

Park, S. A.; Kim, Y.; Gurnari, D.; Dlotko, P.; Hahn, J.

10.1101/2025.03.27.645762 — bioinformatics — Posted on 2025-04-01

5307 Rapid optimization of protein function in mammalian cells via microbe-independent deep assembly and screening

Wu, Y.; Wang, P.; Liu, L. X.; Gao, C.; Qin, Q.; Hageman, M.; Kirkland, T. A.; Su, Y.; Lin, M. Z.

10.1101/2025.03.30.646252 — bioengineering — Posted on 2025-04-01

5308 Multimodal epigenetic and enhancer network remodeling shape the transcriptional landscape of beige adipocytes

Hazell Pickering, S.; Galigniana, N. M.; Abdelhalim, M.; Sorensen, A. L.; Zucknick, M.; Collas, P.; BRIAND, N.

10.1101/2025.03.28.645896 — genomics — Posted on 2025-04-01

5309 Amino Acid Substitutions in the Na+/K+-ATPase May Contribute to Salinity Tolerance in Insects

Achi, P.; Iglesias, V.; Christensen, P.; Adrianza, R.; Bavier, L.; Pena, R.; McCarthy, C.; Groen, S. C.; Dillman, A. R.

10.1101/2025.03.27.645771 — genetics — Posted on 2025-04-01

5310 New alleles of D-2-hydroxyglutarate dehydrogenase enable studies of oncometabolite function in Drosophila melanogaster

Rai, M.; Okah, P.; Shefali, S. A.; Fitt, A. J.; Shen, M. Z.; Molomjamts, M.; Pepin, R.; Nemkov, T.; D'Alessandro, A.; Tennessen, J.

10.1101/2025.03.27.645621 — genetics — Posted on 2025-04-01

5311 Detection of diadromous fish using environmental DNA: prospects for its use in conservation of endangered species occurring in Portugal

Duarte, S.; Santos, A. M.; Antunes, C.; Sousa, R.; Costa, F. O.

10.1101/2025.03.27.645525 — ecology — Posted on 2025-04-01

5312 Vascular Biomechanics and Brain Biochemistry in Aged and Alzheimer's Disease Mouse Models

Jones, A.; Jarrahi, A.; Karpowich, K.; Brown, L.; Schulz, K. M.; Prosser, R. A.; Crouch, C.

10.1101/2025.03.27.645832 — neuroscience — Posted on 2025-04-01

5313 Myelinated fiber labeling and orientation mapping of the human brain with light-sheet fluorescence microscopy

Sorelli, M.; Di Meo, D.; Bradley, S.; Cheli, F.; Ramazzotti, J.; Perego, L.; Destrieux, C.; Hof, P. R.; Pavone, F. S.; Mazzamuto, G.; Costantini, I.

10.1101/2025.03.31.645981 — neuroscience — Posted on 2025-04-01

5314 In situ structure of a gap junction - stomatin complex

Rosenkranz, N.; Wieland, K.; Birtasu, A. N.; Manger, S.; Bhattacharya, A.; Frangakis, A. S.; Gottschalk, A.

10.1101/2025.03.27.645584 — neuroscience — Posted on 2025-04-01

5315 Human visual grouping based on within- and cross-area temporal correlations

Chen, Y.-J.; Sun, Z.; Nishida, S.

10.1101/2025.03.27.645664 — neuroscience — Posted on 2025-04-01

5316 Bedside Assessment of Visual Tracking in Traumatic Brain Injury: Comparing Simple and Predictive Paradigms Using Multiple Oculomotor Markers

Shani, S.; Gavrieli, E.; Kadosh, O.; Sacher, Y.; Cismariu-Potash, K.; Aidinoff, E.; Bonneh, Y. S.

10.1101/2025.03.27.645678 — neuroscience — Posted on 2025-04-01

5317 Wavelet analysis of dual-fMRI-hyperscanning reveals cooperation and communication dependent effects on inter-brain neuronal coherence.

Sijben, R.; Friedmann, R.; Hernandez-Pena, L.; Rodriguez-Raecke, R.

10.1101/2025.03.27.645650 — neuroscience — Posted on 2025-04-01

5318 Neural dynamics of relational memory retrieval across eye movements

Nikolaev, A. R.; Johansson, R.; Bramao, I.; Johansson, M.

10.1101/2025.03.27.645308 — neuroscience — Posted on 2025-04-01

5319 Pathological calcium influx through amyloid beta pores disrupts synaptic function

Adeoye, T.; Ullah, G.

10.1101/2025.03.27.645755 — neuroscience — Posted on 2025-04-01

5320 Baclofen, a GABAB receptor agonist, impairs motor learning in healthy people and changes inhibitory dynamics in motor areas

Grigoras, I. F.; Geist, E.; Johnstone, A.; Clarke, W. T.; Emir, U.; Nettekoven, C.; Levenstein, J. M.; Capitao, L.; Stagg, C. J.

10.1101/2025.03.27.645701 — neuroscience — Posted on 2025-04-01

5321 Caffeine increases false alarms in consolidation of face recognition memory

Leon, C. S.; Lo Celso, A. L.; Guajardo, R.; Forcato, C.

10.1101/2025.03.27.645742 — neuroscience — Posted on 2025-04-01

5322 The Reward Positivity Does Not Encode Current Reward Value

Shaffer, L. S.; Crowder, H. D.; Kakalec, P. A.; Duong, L. T.; McDonald, C. G.; Thompson, J. C.

10.1101/2025.03.27.645774 — neuroscience — Posted on 2025-04-01

5323 Trial-Level Representational Similarity Analysis

Huang, S.; Howard, C. M.; Bogdan, P. C.; Morales-Torres, R.; Slayton, M.; Cabeza, R.; Davis, S. W.

10.1101/2025.03.27.645646 — neuroscience — Posted on 2025-04-01

5324 Synergic microRNAs suppress human glioblastoma progression by modulating clinically relevant targets

Rancati, S.; Pereira, R. C.; Schlich, M.; Sgroi, S.; Beatini, S.; La Rosa, L.; Giantomasi, L.; Pelizzoli, R.; Braccia, C.; Spattini, C.; Tuntevski, K.; Lo Van, A.; Espinal, M. P.; Palange, A.; Bajetto, A.; Daga, A.; Armirotti, A.; Florio, T.; Decuzzi, P.; Tonelli, D. D. P.

10.1101/2025.03.27.645741 — cancer biology — Posted on 2025-04-01

5325 Loss of Kmt2c/d promotes gastric cancer initiation and confers vulnerability to mTORC1 inhibition and anti-PD1 immunotherapy

Wang, N.; Li, D.; Zhang, T.; Pachai, M. R.; Cho, W. H.; Khudoynazarova, M. N.; Schoeps, D. M.; Bao, Y.; Liu, M.; Tang, L.; Janjigian, Y.; Chi, P.; Chen, Y.

10.1101/2025.03.27.645747 — cancer biology — Posted on 2025-04-01

5326 Designed Peptides as Affinity Ligands for Extracellular-Vesicle-based Cancer Biomarker Detection

Sarma, S.; Cho, Y.; Tapdiya, A.; Park, J.; Lee, H.; Hall, C. K.

10.1101/2025.03.27.645572 — cancer biology — Posted on 2025-04-01

5327 The SRG RAT supports human cell xenotransplantation through enhanced tumor microenvironment interactions

O'Connor, C. M.; Zawacki, K. P.; Durrant, J. R.; Barrie, K.; Walton, R. G.; King, D.; Hodges-Onishi, G.; Noto, F. K.; Hinderman, M.; Begemann, D.; Branyan, T.; Panwell, K.; DiFeo, A.; Schlosser, M. J.; Narla, G.

10.1101/2025.03.27.645250 — cancer biology — Posted on 2025-04-01

5328 Divergent Therapeutic and Prognostic Impacts of Immunogenic Features in Undifferentiated Soft Tissue Sarcoma and Myxofibrosarcoma

van Oost, S.; Meijer, D. M.; Erdem, Z. B.; IJsselsteijn, M. E.; Roelands, J.; Lam, S. W.; Boejharat, M. S.; van den Akker, B. E. W. M.; van der Breggen, R.; Briaire-de Bruijn, I. H.; Hawinkels, L. J. A. C.; Kruiswijk, A. A.; van der Ploeg, M.; Wijers-Koster, P. M.; Haas, R. L.; van de Sande, M. A. J.; de Miranda, N. F. C. C.; Bovee, J. V. M. G.

10.1101/2025.03.27.645727 — cancer biology — Posted on 2025-04-01

5329 Single-cell profiling of CAR-T CD19 cell phenotypes and immune system dynamics in pediatric BCP-ALL

Oszer, A.; Pawlik, B.; Cwilichowska-Puslecka, N.; Marschollek, P.; Richert-Przygonska, M.; Mielcarek-Siedziuk, M.; Crawford, J. C.; Mazurek, M.; Koladiya, A.; Kalwak, K.; Styczynski, J.; Janczar, S.; Poreba, M.; Velasquez, P. M.; Davis, K. L.; Mlynarski, W.

10.1101/2025.03.27.645594 — cancer biology — Posted on 2025-04-01

5330 Interplay between BET Proteins and the Pre-Replication Complex Unveils Therapeutic Vulnerabilities in Cancer

Doberstein, K.; Messner, V.; Berlit, S.; Tuschy, B.; Suetterlin, M.; Marme, F.

10.1101/2025.03.27.645172 — cancer biology — Posted on 2025-04-01

5331 HRCHY-CytoCommunity identifies hierarchical tissue organization in cell-type spatial maps

Wang, Z.; Xu, Y.; Hu, Y.; Gao, L.

10.1101/2025.03.27.645631 — bioinformatics — Posted on 2025-04-01

5332 NeighbourNet: Scalable cell-specific co-expression networks for granular regulatory pattern discovery

Deng, Y.; Mao, J.; Choi, J.; Le Cao, K.-A.

10.1101/2025.03.27.645629 — bioinformatics — Posted on 2025-04-01

5333 Revisiting co-expression-based automated function prediction in yeast with neural networks and updated Gene Ontology annotations

McGuire, C. E.; Hibbs, M. A.

10.1101/2025.03.27.645865 — bioinformatics — Posted on 2025-04-01

5334 MouseGPT: A Large-scale Vision-Language Model for Mouse Behavior Analysis

Xu, T.; Zhou, T.; Wang, Y.; Yang, P.; Tang, S.; Shao, K.; Tang, Z.; Liu, Y.; Chen, X.; Wang, H.; Wang, X.; Luo, H.; Wang, J.; Hu, J.; Yu, J.

10.1101/2025.03.27.645630 — animal behavior and cognition — Posted on 2025-04-01

5335 A modular multi-color fluorescence microscope for simultaneous tracking of cellular activity and behavior

Ramahefarivo, E.; Böger, L.; Saichol, T.; Shomali, B.; Scholz, M.

10.1101/2025.04.01.646316 — animal behavior and cognition — Posted on 2025-04-01

5336 Great tits show serial reversal learning in the perseverance phase but not in the new learning phase

Vincze, E.; Brodin, A.

10.1101/2025.03.27.645707 — animal behavior and cognition — Posted on 2025-04-01

5337 Exonic enhancers are a widespread class of dual-function regulatory elements

Mouren, J.-C.; Torres, M.; van Ouwerkerk, A.; Manosalva, I.; Gallardo, F.; Spicuglia, S.; Ballester, B.

10.1101/2025.03.27.645641 — genomics — Posted on 2025-04-01

5338 Bottlenecks and Resistance Evolution against an Antimicrobial 1 Peptide

Kavlak, O.; Linke, L.; Bittermann, E.; Franz, M.; Rolff, J.

10.1101/2025.03.27.645738 — evolutionary biology — Posted on 2025-04-01

5339 Host replacement dynamics shape virulence and genome evolution in a plant RNA virus

Elena, S. F.; Olmo-Uceda, M. J.; Ambros, S.

10.1101/2025.03.27.645716 — evolutionary biology — Posted on 2025-04-01

5340 Experimental Removal of Niche Construction Alters the Pace and Mechanisms of Resistance Evolution

Lo, L. K.; Schulz, N. K. E.; Jensen, H.; Kurtz, J.

10.1101/2025.03.27.645637 — evolutionary biology — Posted on 2025-04-01

5341 Genomic incompatibilities are persistent barriers when speciation happens with gene flow in Formica ants

Heidbreder, P.; Poikela, N.; Nouhaud, P.; Puukko, T.; Lohse, K.; Kulmuni, J.

10.1101/2025.03.27.645773 — evolutionary biology — Posted on 2025-04-01

5342 Weak effects of local prey density and spatial overlap on predation intensity in a temperate marine ecosystem

Lindmark, M.; Griffiths, C. A.; Bartolino, V.; Thunell, V.; Maioli, F.; Anderson, S. C.; Belgrano, A.; Casini, M.; Nadolna-Ałtyn, K.; Pawlak, J.; Pachur, M.; Rakowski, M.; Wikström, K.; Thompson, M. S. A.; Gogina, M.; Ustups, D.; Jacobsen, N. S.

10.1101/2025.03.27.645454 — ecology — Posted on 2025-04-01

5343 Neural crest cell derived DKK1 modulates Wnt signalling in the second heart field to orchestrate cardiac outflow tract development

Wiszniak, S.; Alankarage, D.; Lohraseb, I.; Marchant, C.; Secker, G.; Parker, W.; Toubia, J.; White, M.; Piltz, S.; Tondl, M.; Giannoulatou, E.; Winlaw, D.; Blue, G. M.; Congenital Heart Disease Synergy Group, ; Tam, P. P. L.; Thomas, P.; Harvey, N.; Dunwoodie, S. L.; Schwarz, Q.

10.1101/2025.03.27.645622 — developmental biology — Posted on 2025-04-01

5344 Actin-related protein M1 (ARPM1) required for acrosome biogenesis and sperm function in mice

Kovacevic, A.; Ordziniak, E.; Umer, N.; Arevalo, L.; Hinterlang, L. D.; Ziaeipour, S.; Suvilla, S.; Merges, G. E.; Schorle, H.

10.1101/2025.03.27.645694 — developmental biology — Posted on 2025-04-01

5345 Unique B Cell and Germinal Center Responses in Mice with Severe versus Mild Orientia tsutsugamushi Infection

Gonzales, C.; Liang, Y.; Thiriot, J.; Wang, H.; Villacreses, D.; Sun, J.; Soong, L.

10.1101/2025.03.27.645674 — immunology — Posted on 2025-04-01

5346 The ubiquitin E3 ligase Huwe1 facilitates viral and self RNA sensing by RIG-I-like receptors

Oosenbrug, T.; Gravekamp, D.; Pinto-Fernandez, A.; Crotta, S.; Finsterbusch, K.; van der Kooij, S. B.; ter Haar, L. R.; Asschert, Y.; Kleian, G. F. E.; Kessler, B. M.; Wack, A.; van der Veen, A. G.

10.1101/2025.03.27.645708 — immunology — Posted on 2025-04-01

5347 SB 11285, a Novel Canonical Purine-Pyrimidine Cyclic Dinucleotide, is a Systemically Bioavailable STING Agonist for Cancer Immunotherapy

Challa, R.; Zhou, S.; Sheri, A.; Meher, G.; Padmanabhan, S.; Khedkar, S.; Nair, V.; Gimi, R.; Cleary, D.; Iyer, R. P.

10.1101/2025.03.27.645620 — immunology — Posted on 2025-04-01

5348 Evidence for a RIPK1-independent survival mechanism for CASPASE-8 in αβ T cells

Islam, F.; Layzell, S.; Boal-Carvalho, I.; Seddon, B.

10.1101/2025.03.27.645705 — immunology — Posted on 2025-04-01

5349 A bioprinting approach for high-throughput production of micropatterned neuroepithelial tissues and modeling TSC2-deficient brain malformations

Farahani, N. I.; Wong, K. K. L.; Allen, G.; Minhas, A.; Lin, L.; Nazir, S.; Julian, L. M.

10.1101/2025.03.31.646426 — neuroscience — Posted on 2025-04-01

5350 Targeting Wnt Signaling and DNAJB6/MRJ-L as a Dual Anti-RSV Strategy: Insights into a Positive Regulatory Loop

Lu, C.-Y.; Lai, P.-Y.; Huang, J.-M.; Chang, L.-Y.; Yen, T.-Y.; Tarn, W.-Y.; Huang, L.-M.

10.1101/2025.03.27.645670 — pathology — Posted on 2025-04-01

5351 Genetic surveillance of Plasmodium-Anopheles compatibility markers during Anopheles stephensi associated malaria outbreak

Waymire, E.; Getachew, D.; Gunarathna, I.; Spear, J.; Lloyd, G.; Follis, M.; Kaye, A. A.; Ali, S.; Yared, S.; Carter, T. E.

10.1101/2025.03.26.645571 — evolutionary biology — Posted on 2025-04-01

5352 A Bayesian approach to include Indigenous Knowledge in habitat selection functions

Gryba, R.; Von Duyke, A. L.; Huntington, H. P.; Adams, B.; Frantz, B.; Gatten, J.; Harcharek, Q.; Sarren, R.; Henry, G. H.; Auger-Methe, M.

10.1101/2025.03.26.645387 — ecology — Posted on 2025-04-01

5353 A subset of dorsal raphe dopamine neurons is critical for survival-oriented vigilance.

Guillaumin, A.; Dhellemmes, T.; Perrot, E.; Boi, L.; De Castro Medeiros, D.; Glangetas, C.; Dumas, S.; Dovero, S.; Biendon, N.; Ladeveze, E.; Landry, M.; Bezard, E.; Baufreton, J.; Fisone, G.; Georges, F.

10.1101/2025.03.31.646345 — neuroscience — Posted on 2025-04-01

5354 Delayed development of inner hair cell ribbon synapses in a mouse model of fragile X syndrome

Chojnacka, M.; Skupien-Jaroszek, A.; Dziembowska, M.

10.1101/2025.03.31.646200 — neuroscience — Posted on 2025-04-01

5355 DLPFC Stimulation Suppresses High-Frequency Neural Activity in the Human sgACC

Solomon, E. A.; Hassan, U.; Trapp, N. T.; Boes, A. D.; Keller, C. J.

10.1101/2025.03.26.645556 — neuroscience — Posted on 2025-04-01

5356 Neural sensitivity to the heartbeat is modulated by spontaneous fluctuations in subjective arousal during wakeful rest

Braun, D.; Shareef-Trudeau, L.; Rao, S.; Chesebrough, C.; Kam, J. W. Y.; Kucyi, A.

10.1101/2025.03.26.645574 — neuroscience — Posted on 2025-04-01

5357 A Context-Free Model of Savings in Motor Learning

Shahbazi, M.; Codol, O.; Michaels, J. A.; Gribble, P. L.

10.1101/2025.03.26.645562 — neuroscience — Posted on 2025-04-01

5358 Suite3D: Volumetric cell detection for two-photon microscopy

Haydaroglu, A.; Dodgson, S.; Krumin, M.; Landau, A.; Baruchin, L. J.; Chang, T.; Guo, J.; Meyer, D.; Reddy, C. B.; Zhong, J.; Ji, N.; Schröder, S.; Harris, K. D.; Vaziri, A.; Carandini, M.

10.1101/2025.03.26.645628 — neuroscience — Posted on 2025-04-01

5359 Expansion of OSMR expression and signaling in the human dorsal root ganglion links OSM to neuropathic pain

Mwirigi, J. M.; Sankaranarayanan, I.; Tavares-Ferreira, D.; Gabriel, K. A.; Palomino, S.; Li, Y.; Uhelski, M. L.; Shiers, S.; Franco-Enzastiga, U.; Wangzhou, A.; Lesnak, J. B.; Bandaru, S.; Shrivastava, A.; Inturi, N.; Albrecht, P. J.; Dockum, M.; Cervantes, A. M.; Horton, P.; Funk, G.; North, R. Y.; Tatsui, C. E.; Corrales, G.; Yousuf, M. S.; Curatolo`, M.; Gereau, R. W.; Patwardhan, A.; Dussor, G.; Dougherty, P. M.; Rice, F. L.; Price, T. J.

10.1101/2025.03.26.645611 — neuroscience — Posted on 2025-04-01

5360 DIFS: Discriminative Feature Selection for Cell Clustering based on Single-Cell RNA Sequencing Data

Liu, K.; Liu, J.; Wang, C.

10.1101/2025.03.26.645625 — bioinformatics — Posted on 2025-04-01

5361 PiP-plex: A Particle-in-Particle System for Multiplexed Quantification of Secreted Proteins by Single Cells

Lussier, F.; Moon, B.-U.; Janta-Polczynski, M.; Morocz, Y.; Svahn, F.; Shen, M. L.; Lukic, L.; Malic, L.; Veres, T.; Ng, A.; Juncker, D.

10.1101/2025.03.26.645608 — bioengineering — Posted on 2025-04-01

5362 FOS binding sites are a hub for the evolution of activity-dependent gene regulatory programs in human neurons

Carter, A. C.; Koreman, G. T.; Petrocelli, J. E.; Robb, J. E.; Bushinsky, E. M.; Trowbridge, S. K.; Kingsley, D. M.; Walsh, C. A.; Song, J. H. T.; Greenberg, M. E.

10.1101/2025.03.31.646366 — evolutionary biology — Posted on 2025-04-01

5363 Binomial order is a speech marker of psychosis and thought disorder

Luo, A.; Luo, J.; Murphy, M.

10.1101/2025.03.31.646413 — neuroscience — Posted on 2025-04-01

5364 Impact of education and music training on the development of early abstraction abilities

Morfoisse, T.; Becuwe, S.; Palu, M.; Potier-Watkins, C.; Dehaene-Lambertz, G.; Dehaene, S.

10.1101/2025.03.28.645996 — neuroscience — Posted on 2025-04-01

5365 Autogenic spinal excitatory circuit ensures skilled hand movements in primates

Kim, G.; Tomatsu, S.; Umeda, T.; Takei, T.; Funato, T.; Seki, K.

10.1101/2025.03.31.646263 — neuroscience — Posted on 2025-04-01

5366 An unsuspected physiological role for mGluRIII glutamate receptors in hippocampal area CA1

Petroccione, M.; Melone, M.; Rathwell, T.; Dwivedi, N.; Grienberger, C.; Conti, F.; Scimemi, A.

10.1101/2025.03.31.646479 — neuroscience — Posted on 2025-04-01

5367 Prefrontal parvalbumin neurons as a target for enhancing cognition in non-pathological and 22q11.2 microdeletion syndrome mice

Dexter, T. D.; Palmer, D.; Schormans, A. L.; Hamidullah, S.; Machado, M. M. F.; Allman, B. L.; Bussey, T. J.; Saksida, L. M.

10.1101/2025.03.31.645999 — neuroscience — Posted on 2025-04-01

Archive, 2025-04