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Archive, 2021-07

3 Accurate Automatic Glioma Segmentation in Brain MRI images Based on CapsNet
Jalili Aziz, M.; Amiri Tehrani Zade, A.; Farnia, P.; Alimohammadi, M.; Makki Abadi, B.; Ahmadian, A.; Alirezaie, J.
10.1101/2021.07.03.450931 — bioengineering — Posted on 2021-07-31
4 The immediate early protein 1 of the human herpesvirus 6B counteracts NBS1 and prevents homologous recombination repair pathways
Collin, V.; Biquand, E.; Tremblay, V.; Lavoie, E. G.; Dessapt, J.; Gravel, A.; Flamand, L.; Fradet-Turcotte, A.
10.1101/2021.07.31.454588 — microbiology — Posted on 2021-07-31
8 Identification of the Global miR-130a Targetome Reveals a Novel Role for TBL1XR1 in Hematopoietic Stem Cell Self-Renewal and t(8;21) AML
Krivdova, G.; Voisin, V.; Schoof, E. M.; Marhon, S. A.; Murison, A. J.; McLeod, J. L.; Gabra, M.; Zeng, A. G.; Van Nostrand, E. L.; Aigner, S. J.; Shishkin, A. A.; Yee, B. A.; Hermans, K. G.; Trotman-Grant, A. G.; Mbong, N.; Kennedy, J. A.; Gan, O. I.; Wagenblast, E.; De Carvalho, D. D.; Salmena, L.; Minden, M. D.; Bader, G. D.; Yeo, G. W.; Dick, J. E.; Lechman, E. R.
10.1101/2021.07.30.454489 — cell biology — Posted on 2021-07-31
13 Invertebrate methylomes provide insight into mechanisms of environmental tolerance and reveal methodological biases
Trigg, S. A.; Venkataraman, Y. R.; Gavery, M.; Roberts, S. B.; Bhattacharya, D.; Downey-Wall, A.; Eirin-Lopez, J. M.; Johnson, K. M.; Lotterhos, K. E.; Puritz, J. B.; Putnam, H. M.
10.1101/2021.03.29.437539 — genomics — Posted on 2021-07-31
16 Asymmetric requirement of Dpp/BMP morphogen dispersal in the Drosophila wing disc
Matsuda, S.; Schaefer, J. V.; Mii, Y.; Hori, Y.; Bieli, D.; Taira, M.; Plueckthun, A.; Affolter, M.
10.1101/2020.11.23.394379 — developmental biology — Posted on 2021-07-31
19 Synaptic plasticity regulated by phosphorylation of PSD-95 Serine 73 in dorsal CA1 is required for contextual fear extinction
Ziolkowska, M.; Borczyk, M.; Nowacka, A.; Nalberczak-Skora, M.; Sliwinska, M. A.; Robacha, M.; Lukasiewicz, K.; Caly, A.; Skonieczna, E.; Tomaszewski, K. F.; Wojtowicz, T.; Wlodarczyk, J.; Bernas, T.; Salamian, A.; Radwanska, K.
10.1101/2020.11.13.381368 — neuroscience — Posted on 2021-07-31
27 Development of an efficient single-cell cloning and expansion strategy for genome edited induced pluripotent stem cells
Bhargava, N.; Thakur, P.; Muruganandam, T. P.; Jaitly, S.; Gupta, P.; Lohani, N.; Goswami, S. G.; Bhattacharya, S. K.; Jain, S.; Ramalingam, S.
10.1101/2021.07.31.453934 — cell biology — Posted on 2021-07-31
29 Xenotransplantation of porcine progenitor cells in an epileptic California sea lion (Zalophus californianus)
Simeone, C. A.; Andrews, J. P.; Johnson, S. P.; Casalia, M.; Kochanski, R.; Chang, E. F.; Cameron, D.; Dennison, S.; Inglis, B.; Scott, G.; Kruse-Elliott, K.; Okonski, F. F.; Calvo, E.; Goulet, K.; Robles, D.; Griffin-Stence, A.; Kuiper, E.; Krasovec, L.; Field, C. L.; Hoard, V. F.; Baraban, S. C.
10.1101/2021.07.30.454497 — neuroscience — Posted on 2021-07-31
31 Exploring the miRNA-mediated response to combined stresses in melon plants
Villalba-Bermell, P.; Marquez-Molins, J.; Marques, M.-C.; Hernandez-Azurdia, A.; Corell-Sierra, J.; Pico, B.; Monforte, A. J.; Elena, S. F.; Gomez, G.
10.1101/2021.07.30.454429 — plant biology — Posted on 2021-07-31
32 Emergence of distinct and heterogeneous strains of amyloid beta as Alzheimer s disease progresses in Down syndrome
Maxwell, A. M.; Yuan, P.; Rivera, B. M.; Schaaf, W.; Mladinov, M.; Prasher, V. P.; Robinson, A. C.; DeGrado, W. F.; Condello, C.
10.1101/2021.07.30.454527 — pathology — Posted on 2021-07-31
35 Assessment of label-free quantification and missing value imputation for proteomics in non-human primates
Hamid, Z.; Zimmerman, K. D.; Guillen-Ahlers, H.; Li, C.; Nathanielsz, P.; Cox, L. A.; Olivier, M.
10.1101/2021.07.30.454221 — genomics — Posted on 2021-07-31
36 Uncovering perturbations in human hematopoiesis associated with healthy aging and myeloid malignancies at single cell resolution
Ainciburu, M.; Ezponda, T.; Berastegui, N.; Alfonso-Pierola, A.; Vilas-Zornoza, A.; San Martin-Uriz, P.; Alignani, D.; Lamo de Espinosa, J.; San Julian, M.; Jimenez, T.; Lopez, F.; Muntion, S.; Sanchez-Guijo, F.; Molero, A.; Montoro, J.; Serrano, G.; Diaz-Mazkiaran, A.; Lasaga, M.; Gomez-Cabrero, D.; Diez-Campelo, M.; Valcarcel, D.; Hernaez, M.; Romero, J. P.; Prosper, F.
10.1101/2021.07.30.454542 — genomics — Posted on 2021-07-31
38 Telmisartan restricts Chikungunya virus infection in vitro and in vivo through the AT1/ PPAR-γ/MAPKs pathways
De, S.; Mamidi, P.; Ghosh, S.; Keshry, S. S.; Mahish, C.; Pani, S. S.; Laha, E.; Ray, A.; Datey, A.; Chatterjee, S.; Singh, S.; Mukherjee, T.; Khamaru, S.; Chattopadhyay, S.; Subudhi, B. B.; Chattopadhyay, S.
10.1101/2021.07.30.454559 — microbiology — Posted on 2021-07-31
39 Engineering adoptive T cell therapy to co-opt Fas ligand-mediated death signaling in ovarian cancer enhances therapeutic efficacy
Anderson, K. G.; Oda, S. K.; Bates, B. M.; Burnett, M. G.; Rodgers Suarez, M.; Ruskin, S. L.; Greenberg, P. D.
10.1101/2021.07.30.454539 — immunology — Posted on 2021-07-31
41 Modular Fluorescent Nanoparticle DNA Probes for Detection of Peptides and Proteins
Stawicki, C. M.; Rinker, T. E.; Burns, M.; Tonapi, S. S.; Galimidi, R. P.; Anumala, D.; Robinson, J. K.; Klein, J. S.; Mallick, P.
10.1101/2021.07.30.454524 — bioengineering — Posted on 2021-07-31
43 Social selectivity and social motivation in voles
Beery, A. K.; Lopez, S. A.; Blandino, K. L.; Lee, N. S.; Bourdon, N. S.; Ahern, T. H.
10.1101/2021.07.30.454556 — neuroscience — Posted on 2021-07-31
44 Surface Electromyography for Identification of Pre-Phonatory Activity
Kothare, H.; Courey, M. S.; Yung, K. C.; Schneider, S. L.; Nagarajan, S.; Houde, J.
10.1101/2021.07.29.454386 — physiology — Posted on 2021-07-31
45 Molecular dissection of Carbapenem-resistant Acinetobacter baumannii circulating in Indian hospitals usingWhole Genome Sequencing
Rose, S.; Shamanna, V.; Underwood, A.; Nagaraj, G.; Prasanna, A.; Govindan, V.; Darmavaram, S.; M R, S.; Argimon, S.; A, M.; Aanensen, D.; K L, R.
10.1101/2021.07.30.454432 — genomics — Posted on 2021-07-31
47 Deficiency of the ywhaz gene, involved in neurodevelopmental disorders, alters brain activity and behaviour in zebrafish
Anton-Galindo, E.; Dalla Vecchia, E.; Orlandi, J. G.; Castro, G.; Gualda, E.; Young, A. M.; Aguado, F.; Loza-Alvarez, P.; Cormand, B.; Norton, W. H.; Fernandez-Castillo, N.
10.1101/2021.06.30.450513 — neuroscience — Posted on 2021-07-31
49 The olfactory gating of visual preferences to human skin and colors in mosquitoes
Alonso San Alberto, D.; Rusch, C.; Zhan, Y.; Straw, A. D.; Montell, C.; Riffell, J. A.
10.1101/2021.07.26.453916 — neuroscience — Posted on 2021-07-31
52 Shaping sustainable harvest boundaries for marine populations despite estimation bias
Goto, D.; Devine, J.; Umar, I.; Fischer, S.; De Oliveira, J.; Howell, D.; Jardim, E.; Mosqueira, I.; Ono, K.
10.1101/2020.12.05.413070 — ecology — Posted on 2021-07-31
53 Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development
Mead, T. J.; Martin, D. R.; Wang, L. W.; Cain, S. A.; Gulec, C.; Cahill, E.; Mauch, J.; Reinhardt, D. P.; Lo, C. W.; Baldock, C.; APTE, S.
10.1101/2021.02.03.429587 — developmental biology — Posted on 2021-07-31
56 Structural basis for the therapeutic advantage of dual and triple agonists at the human GIP, GLP-1 or GCG receptors
Zhao, F.; Zhou, Q.; Cong, Z.; Hang, K.; Zou, X.; Zhang, C.; Chen, Y.; Dai, A.; Liang, A.; Ming, Q.; Wang, M.; Chen, L.; Xu, P.; Chang, R.; Feng, W.; Xia, T.; Zhang, Y.; Wu, B.; Yang, D.; Zhao, L.; Xu, H. E.; Wang, M.-W.
10.1101/2021.07.29.454286 — molecular biology — Posted on 2021-07-31
57 Multi-tier mechanics control stromal adaptations in swelling lymph nodes
Assen, F. P.; Hons, M.; Hauschild, R.; Shamipour, S.; Abe, J.; Kaufmann, W. A.; Costanzo, T.; Krens, G.; Brown, M.; Ludewig, B.; Hippenmeyer, S.; Stein, J. V.; Heisenberg, C.-P.; Hannezo, E.; Luther, S. A.; Sixt, M.
10.1101/2021.07.28.454217 — immunology — Posted on 2021-07-31
60 The heart rate discrimination task: a psychophysical method to estimate the accuracy and precision of interoceptive beliefs
Legrand, N.; Nikolova, N.; Correa, C.; Braendholt, M.; Stuckert, A.; Kildahl, N.; Vejlo, M.; Fardo, F.; Allen, M.
10.1101/2021.02.18.431871 — neuroscience — Posted on 2021-07-31
66 Phenotyping of Klf14 mouse white adipose tissue enabled by whole slide segmentation with deep neural networks
Casero, R.; Westerberg, H.; Horner, N. R.; Yon, M.; Aberdeen, A.; Grau, V.; Cox, R. D.; Rittscher, J.; Mallon, A.-M.
10.1101/2021.06.03.444997 — bioinformatics — Posted on 2021-07-30
69 Intrinsically disordered N-terminal domain (NTD) of p53 interacts with mitochondrial PTP regulator Cyclophilin D
Zhao, J.; Liu, X.; Blayney, A.; Zhang, Y.; Gandy, L.; Zhang, F.; Linhardt, R. J.; Chen, J.; Baines, C.; Loh, S. N.; Wang, C.
10.1101/2021.07.23.453429 — biochemistry — Posted on 2021-07-30
71 NHR-8 regulated P-glycoproteins uncouple xenobiotic stress resistance from longevity in chemosensory C. elegans mutants
Guerrero, G. A.; Derisbourg, M. J.; Wester, L. E.; Giorda, M.; Dinort, J. E.; Alonso, M. J.; Hartman, M. D.; Schilling, K.; Mayr, F. A. M. C.; Lu, R.; Benayoun, B. A.; Denzel, M. S.
10.1101/823302 — genetics — Posted on 2021-07-30
72 Inference of recent admixture using genotype data
Pfaffelhuber, P.; Sester-Huss, E.; Baumdicker, F.; Naue, J.; Lutz-Bonengel, S.; Staubach, F.
10.1101/2020.09.16.300640 — genetics — Posted on 2021-07-31
73 The role of muscle stem cells and fibro-adipogenic progenitors in female pelvic floor muscle regeneration following birth injury
Boscolo Sesillo, F.; Rajesh, V.; Wong, M.; Duran, P.; Baynes, B.; Laurent, L. C.; Christman, K.; Sacco, A.; Alperin, M.
10.1101/2021.07.30.454534 — cell biology — Posted on 2021-07-31
75 Genome assemblies across the diverse evolutionary spectrum of Leishmania protozoan parasites
Warren, W. C.; Akopyants, N.; Dobson, D. E.; Hertz-Fowler, C.; Lye, L.-F.; Myler, P. J.; Ramasamy, G.; Shanmugasundram, A.; Silva-Franco, F.; Steinbiss, S.; Tomlinson, C.; Wilson, R. K.; Beverley, S. M.
10.1101/2021.05.29.446295 — microbiology — Posted on 2021-07-30
76 Tissue homeostasis and adaptation to immune challenge resolved by fibroblast network mechanics
Horsnell, H. L.; Tetley, R. J.; de Belly, H.; Makris, S.; Benjamin, A. C.; Paluch, E.; Mao, Y.; Acton, S. E.
10.1101/2021.05.27.446027 — immunology — Posted on 2021-07-30
77 Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at Chr16q11.2 and on the MAPT H1 allele
Soutar, M.; Melandri, D.; O'Callaghan, B.; Annuario, E.; Monaghan, A.; Welsh, N.; D'Sa, K.; Guelfi, S.; Zhang, D.; Pittman, A.; Trabzuni, D.; Pan, K.; Kia, D. A.; Bictash, M.; Gandhi, S.; Houlden, H.; Cookson, M. R.; Wood, N.; Singleton, A.; Hardy, J.; Whiting, P.; Blauwendraat, C.; Whitworth, A.; Manzoni, C.; Ryten, M.; Lewis, P.; Plun-Favreau, H.
10.1101/2020.01.06.896241 — neuroscience — Posted on 2021-07-30
80 Identification of an isoflavonoid transporter required for the nodule establishment of the Rhizobium-Fabaceae symbiotic interaction
Biala-Leonhard, W.; Zanin, L.; Gottardi, S.; de Brito Francisco, R.; Venuti, S.; Valentinuzzi, F.; Mimmo, T.; Cesco, S.; Bassin, B.; Martinoia, E.; Pinton, R.; Jasinski, M.; Tomasi, N.
10.1101/2021.07.30.452494 — plant biology — Posted on 2021-07-30
81 HGFAC is a ChREBP Regulated Hepatokine that Enhances Glucose and Lipid Homeostasis
Sargsyan, A.; Doridot, L.; Hannou, S. A.; Tong, W.; Srinivasan, H.; Ivison, R.; Monn, R.; Kou, H. H.; Haldeman, J. M.; Arlotto, M.; White, P. J.; Grimsrud, P. A.; Astapova, I.; Tsai, L.; Herman, M. A.
10.1101/2021.07.29.454308 — physiology — Posted on 2021-07-30
82 Accurate recognition of colorectal cancer with semi-supervised deep learning on pathological images
Yu, G.; Xie, T.; Xu, C.; Shi, X.-H.; Wu, C.; Sun, K.; Meng, R.-Q.; Meng, X.-H.; Wang, K.-S.; Xiao, H.-M.; Deng, H.-W.
10.1101/2020.07.13.201582 — pathology — Posted on 2021-07-30
83 ZIP9 is a Druggable Determinant of Sex Differences in Melanoma
Aguirre-Portoles, C.; Payne, R.; Trautz, A.; Foskett, J. K.; Natale, C. A.; Seykora, J. T.; Ridky, T. W.
10.1101/2020.03.12.989160 — cancer biology — Posted on 2021-07-30
85 Natural isotope correction improves analysis of protein modification dynamics
Dietze, J.; van Pijkeren, A.; Egger, A.-S.; Ziegler, M.; Kwiatkowski, M.; Heiland, I.
10.1101/2020.10.31.361725 — bioinformatics — Posted on 2021-07-30
86 Probing T-cell response by sequence-based probabilistic modeling
Bravi, B.; Balachandran, V. P.; Greenbaum, B. D.; Walczak, A. M.; Mora, T.; Monasson, R.; Cocco, S.
10.1101/2020.12.17.423283 — bioinformatics — Posted on 2021-07-30
91 Identification of the Global miR-130a Targetome Reveals a Novel Role for TBL1XR1 in Hematopoietic Stem Cell Self-Renewal and t(8;21) AML
Krivdova, G.; Voisin, V.; Schoof, E. M.; Marhon, S. A.; Murison, A. J.; McLeod, J. L.; Gabra, M.; Zeng, A. G.; Van Nostrand, E. L.; Aigner, S. J.; Shishkin, A. A.; Yee, B. A.; Hermans, K. G.; Trotman-Grant, A. G.; Mbong, N.; Kennedy, J. A.; Gan, O. I.; Wagenblast, E.; De Carvalho, D. D.; LAB, S.; Minden, M. D.; Bader, G. D.; Yeo, G. W.; Dick, J. E.; Lechman, E. R.
10.1101/2021.07.30.454489 — cell biology — Posted on 2021-07-30
92 Highly efficient SARS-CoV-2 infection of human cardiomyocytes: spike protein-mediated cell fusion and its inhibition
Navaratnarajah, C. K.; Pease, D. R.; Halfmann, P.; Taye, B.; Barkhymer, A.; Howell, K. G.; Charlesworth, J. E.; Christensen, T. A.; Kawaoka, Y.; Cattaneo, R.; Schneider, J. W.; Timothy J. Nelson (Director), Boyd Rasmussen and Frank J. Secreto,
10.1101/2021.07.30.454437 — microbiology — Posted on 2021-07-30
93 Evolution of protection after maternal immunization for respiratory syncytial virus in cotton rats
Blanco, J. C. G.; McGinnes-Cullen, L.; Kamali, A.; Sylla, F.; Boukhavalova, M.; Morrison, T.
10.1101/2021.07.30.454440 — microbiology — Posted on 2021-07-30
94 Smallpox vaccination induces a substantial increase in commensal skin bacteria that promote pathology and enhance immunity
Shmeleva, E. V.; Gomez de Agüero, M.; Wagner, J.; Enright, A. J.; Macpherson, A. J.; Ferguson, B. J.; Smith, G. L.
10.1101/2021.07.30.454438 — microbiology — Posted on 2021-07-30
95 Collagen (I) homotrimer potentiates the osteogenesis imperfecta (oim) mutant allele and reduces survival in male mice
Lee, K. J.; Rambault, L.; Bou-Gharios, G.; Clegg, P. D.; Akhtar, R.; Czanner, G.; van 't Hof, R. J.; Canty-Laird, E. G.
10.1101/2020.07.13.198283 — physiology — Posted on 2021-07-30
96 Doxycycline inhibition of a pseudotyped virus transduction does not translate to inhibition of SARS-CoV-2 infectivity
Diomede, L.; Baroni, S.; De Luigi, A.; Piotti, A.; Lucchetti, J.; Fracasso, C.; Russo, L.; Bonaldo, V.; Panini, N.; Filippini, F.; Fiordaliso, F.; Corbelli, A.; Beeg, M.; Pizzato, M.; Caccuri, F.; Gobbi, M.; Biasini, E.; Caruso, A.; Salmona, M.
10.1101/2021.07.30.454436 — pharmacology and toxicology — Posted on 2021-07-30
99 Phosphoproteomic analysis of chondrocytes after short-term exposure to inorganic polyphosphate
Kuzmanov, U.; Gawri, R.; Zelinka, A.; Russel, K. A.; Lee, S.-H.; Gramolini, A. O.; Kandel, R.
10.1101/2021.07.30.454470 — bioengineering — Posted on 2021-07-30
100 Directed biosynthesis of fluorinated polyketides
Rittner, A.; Joppe, M.; Schmidt, J. J.; Mayer, L. M.; Heid, E.; Sherman, D. H.; Grininger, M.
10.1101/2021.07.30.454469 — biochemistry — Posted on 2021-07-30
101 Molecular dissection of Carbapenem-resistant Acinetobacter baumannii circulating in Indian hospitals usingWhole Genome Sequencing
Rose, S.; Shamanna, V.; Underwood, A.; Nagaraj, G.; Prasanna, A.; Govindan, V.; Darmavaram, S.; M R, S.; Argimon, S.; A, M.; Aanensen, D.; K L, R.
10.1101/2021.07.30.454432 — genomics — Posted on 2021-07-30
102 Epigenetic Divergence during Early Stages of Speciation in an African Crater Lake Cichlid Fish
Vernaz, G.; Hudson, A. G.; Santos, M. E.; Fischer, B.; Carruthers, M.; Shechonge, A. H.; Gabagambi, N. P.; Tyers, A. M.; Ngatunga, B. P.; Malinsky, M.; Durbin, R.; Turner, G. F.; Genner, M. J.; Miska, E. A.
10.1101/2021.07.30.435319 — genomics — Posted on 2021-07-30
103 The genetic origin of Daunians and the Pan-Mediterranean southern Italian Iron Age context
Aneli, S.; Saupe, T.; Montinaro, F.; Solnik, A.; Molinaro, L.; Scaggion, C.; Carrara, N.; Raveane, A.; Kivisild, T.; Metspalu, M.; Scheib, C. L.; Pagani, L.
10.1101/2021.07.30.454498 — genetics — Posted on 2021-07-30
105 Localization of infection in neonatal rhesus macaques after oral viral challenge
Hope, T. J.; Taylor, R. A.; McRaven, M. D.; Carias, A. M.; Anderson, M. R.; Matias, E.; Arainga, M.; Allen, E. J.; Rogers, K. A.; Gupta, S.; Kulkarni, V.; Lakhashe, S.; Lorenzo-Redondo, R.; Thomas, Y.; Strickland, A.; Villinger, F. J.; Ruprecht, R. M.
10.1101/2021.07.30.454439 — cell biology — Posted on 2021-07-30
106 A new paradigm for leprosy diagnosis based on host gene expression
Leal-Calvo, T.; Avanzi, C.; Mendes, M. A.; Benjak, A.; Busso, P.; Pinheiro, R. O.; Sarno, E. N.; Cole, S. T.; Moraes, M. O.
10.1101/2021.07.30.454441 — molecular biology — Posted on 2021-07-30
108 Genomic and chemical decryption of the Bacteroidetes phylum for its potential to biosynthesize natural products
Brinkmann, S.; Kurz, M.; Patras, M. A.; Hartwig, C.; Marner, M.; Leis, B.; Billion, A.; Kleiner, Y.; Bauer, A.; Toti, L.; Poeverlein, C.; Hammann, P. E.; Vilcinskas, A.; Glaeser, J.; Spohn, M. S.; Schaeberle, T. F.
10.1101/2021.07.30.454449 — microbiology — Posted on 2021-07-30
110 Roscovitine exacerbates Mycobacterium abscessus infection by reducing NADPH oxidase-dependent neutrophil trafficking
Le Moigne, V.; Rodriguez Rincon, D.; Glatigny, S.; Dupont, C.; Langevin, C.; Ait Ali Said, A.; Renshaw, S. A.; Floto, A. R.; Herrmann, J.-L.; Bernut, A.
10.1101/2021.07.30.454490 — microbiology — Posted on 2021-07-30
113 CD49a Identifies Polyfunctional Memory CD8 T cell Subsets that Persist in the Lungs after Influenza Infection
Reilly, E. C.; Sportiello, M.; Lambert Emo, K.; Amitrano, A. M.; Jha, R.; Kumar, A. B.; Laniewski, N. G.; Yang, H.; Kim, M.; Topham, D. J.
10.1101/2021.07.30.454373 — immunology — Posted on 2021-07-30
114 Regeneration of humoral immunity from pluripotent stem cells by defined transcription factors
Zhang, Q.; Wu, B.; Weng, Q.; Hu, F.; Lin, Y.; Xia, C.; Peng, H.; Wang, Y.; Liu, X.; Liu, L.; Xiong, J.; Geng, Y.; Zhao, Y.; Zhang, M.; Du, J.; Wang, J.
10.1101/2021.07.30.454442 — immunology — Posted on 2021-07-30
115 Activation of M1 muscarinic receptors reduce pathology and slow progression of neurodegenerative disease.
Dwomoh, L.; Rossi, M.; Scarpa, M.; Khajehali, E.; Molloy, C.; Herzyk, P.; Mistry, S. N.; Bottrill, A.; Sexton, P. M.; Christopoulos, A.; Conn, J. P.; Lindsley, C. W.; Bradley, S. J.; Tobin, A. B.
10.1101/2021.07.30.454298 — neuroscience — Posted on 2021-07-30
116 PROTECTIVE ROLE FOR SMOOTH MUSCLE CELL HEPCIDIN IN ABDOMINAL AORTIC ANEURYSM
Loick, P.; Mohammad, G.; Cassinmjee, I.; Chandrashekar, A.; Lapolla, P.; Carrington, A.; Handa, A.; Lee, R.; Lakhal-Littleton, S.
10.1101/2021.07.30.454447 — physiology — Posted on 2021-07-30
117 PERK inhibition blocks metastasis initiation by limiting UPR-dependent survival of dormant disseminated cancer cells
Calvo, V.; Zheng, W.; Staschke, K. A.; Nobre, A. R.; Farias, E. F.; Nowacek, A.; Mulvihill, M.; Rigby, A. C.; Aguirre-Ghiso, J. A.
10.1101/2021.07.30.454473 — cancer biology — Posted on 2021-07-30
119 Lipid flippase dysfunction as a novel therapeutic target for endosomal anomalies in Alzheimer's disease
KANESHIRO, N.; MASATO, K.; IMAOKA, R.; IKEDA, A.; KAMIKUBO, Y.; HASHIMOTO, T.; IWATSUBO, T.; SAKURAI, T.; UEHARA, T.; TAKASUGI, N.
10.1101/2021.07.30.454423 — biochemistry — Posted on 2021-07-30
120 COVID-ONE-humoral immune: The One-stop Database for COVID-19-specific Antibody Responses and Clinical Parameters
Xu, Z.; Li, Y.; Lei, Q.; Huang, L.; Lai, D.-y.; Guo, S.-j.; Jiang, H.-w.; Hou, H.; Zheng, Y.-x.; Wang, X.-n.; Wu, J.; Ma, M.-l.; Zhang, B.; Chen, H.; Yu, C.; Xue, J.-b.; Zhang, H.-n.; Qi, H.; Yu, S.; Lin, M.; Zhang, Y.; Lin, X.; Yao, Z.; Sheng, H.; Sun, Z.; Wang, F.; Fan, X.; Tao, S.-c.
10.1101/2021.07.29.454261 — microbiology — Posted on 2021-07-30
121 SARS-CoV-2 introduction and lineage dynamics across three epidemic peaks in Southern Brazil: massive spread of P.1
Varela, A. P. M.; Prichula, J.; Meyer, F. Q.; Salvato, R.; Sant'Anna, F. H.; Gregianini, T. S.; Martins, L. G.; Seixas, A.; Veiga, A. B. G. d.
10.1101/2021.07.29.454323 — genomics — Posted on 2021-07-30
122 Structural basis for the therapeutic advantage of dual and triple agonists at the human GIP, GLP-1 or GCG receptors
Zhao, F.; Zhou, Q.; Cong, Z.; Hang, K.; Zou, X.; Zhang, C.; Chen, Y.; Dai, A.; Liang, A.; Ming, Q.; Wang, M.; Chen, L.; Xu, P.; Chang, R.; Feng, W.; Xia, T.; Zhang, Y.; Wu, B.; Yang, D.; Zhao, L.; Xu, H. E.; Wang, M.-W.
10.1101/2021.07.29.454286 — molecular biology — Posted on 2021-07-30
125 3D printed cobalt-chromium-molybdenum porous superalloy with superior antiviral activity
Arjunan, A.; Robinson, J.; Baroutaji, A.; Marti, M.; Tunon-Molina, A.; Serrano-Aroca, A.
10.1101/2021.07.29.454385 — bioengineering — Posted on 2021-07-30
126 A method for the generation of pseudotyped virus particles bearing SARS coronavirus spike protein in high yields
Fujioka, Y.; Kashiwagi, S.; Yoshida, A.; Satoh, A. O.; Fujioka, M.; Amano, M.; Yamauchi, Y.; Ohba, Y.
10.1101/2021.07.30.454063 — microbiology — Posted on 2021-07-30
128 Neural-specific alterations in glycosphingolipid biosynthesis and cell signaling associated with two human ganglioside GM3 Synthase Deficiency variants
Dookwah, M.; Wagner, S. K.; Ishihara, M.; Yu, S.-h.; Ulrichs, H.; Kulik, M. J.; Zeltner, N.; Dalton, S.; Strauss, K. A.; Aoki, K.; Steet, R.; Tiemeyer, M.
10.1101/2021.07.29.454399 — neuroscience — Posted on 2021-07-30
129 A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae
Kaplonek, P. M.; Yao, L.; Reppe, K.; Voss, F. M.; Kohler, T.; Ebner, F.; Schaefer, A.; Blohm, U.; Priegue, P.; Brautigam, M.; Pereira, C. L.; Parameswarappa, S. G.; Emmadi, M.; Menova, P.; Witzenrath, M.; Hammerschmidt, S.; Hartmann, S.; Sander, L. E.; Seeberger, P. H.
10.1101/2021.07.29.454378 — immunology — Posted on 2021-07-30
130 Surface Electromyography for Identification of Pre-Phonatory Activity
Kothare, H.; Courey, M. S.; Yung, K. C.; Schneider, S. L.; Nagarajan, S.; Houde, J.
10.1101/2021.07.29.454386 — physiology — Posted on 2021-07-30
132 MOSGA 2: Comparative genomics and validation tools
Martin, R.; Dressler, H.; Hattab, G.; Hackl, T.; Fischer, M. G.; Heider, D.
10.1101/2021.07.29.454382 — bioinformatics — Posted on 2021-07-30
133 Removing the ceiling on droplet microfluidics
Khor, J. W.; Lee, U. N.; Berthier, J.; Berthier, E.; Theberge, A. B.
10.1101/2021.07.29.454194 — bioengineering — Posted on 2021-07-30
134 A small-molecule fluorescent probe for live-cell imaging of endocytosis
Seino, R.; Iwashita, H.; Takahashi, M.; Ezoe, T.; Ishiyama, M.; Ueno, Y.
10.1101/2021.07.29.454398 — biochemistry — Posted on 2021-07-30
137 Exogenous pigments shield microorganisms from spaceflight-induced changes
Sharma, S.; Smith, R. S. H.; Lee, N. A.; Wilson, S. L.; Smith, M. M.; Oxman, N.
10.1101/2021.07.29.454367 — microbiology — Posted on 2021-07-30
140 Training a spiking neuronal network model of visual-motor cortex to play a virtual racket-ball game using reinforcement learning
Anwar, H.; Caby, S.; Dura-Bernal, S.; D'Onofrio, D.; Hasegan, D.; Deible, M.; Grunblatt, S.; Chadderdon, G. L.; Kerr, C. C.; Lakatos, P.; Lytton, W. W.; Hazan, H.; Neymotin, S. A.
10.1101/2021.07.29.454361 — neuroscience — Posted on 2021-07-30
141 Large-scale dendritic spine extraction and analysis through petascale computing
Wildenberg, G.; Li, H.; Badalamente, G. A.; Uram, T. D.; Ferrier, N.; Kasthuri, N.
10.1101/2021.07.29.454371 — neuroscience — Posted on 2021-07-30
143 Carbon nanotube biocompatibility in plants is determined by their surface chemistry
Gonzalez-Grandio, E.; Demirer, G. S.; Jackson, C. T.; Yang, D.; Landry, M. P.
10.1101/2021.07.29.454380 — plant biology — Posted on 2021-07-30
145 Temporal variation in lymphocyte proteomics
McCown, M. A.; Allen, C.; Machado, D. D.; Boekweg, H.; Liang, Y.; Nwosu, A. J.; Kelly, R. T.; Payne, S. H.
10.1101/2021.07.29.454362 — bioinformatics — Posted on 2021-07-30
147 Discovery of small molecule pathway regulators by image profile matching
Rohban, M. H.; Fuller, A. M.; Tan, C.; Goldstein, J. T.; Syangtan, D.; Gutnick, A.; Nijsure, M. P.; Rigby, M.; Sacher, J. R.; Corsello, S. M.; Peppler, G. B.; Bogaczynska, M.; Ciotti, G. E.; DeVine, A.; Doan, M.; Gale, J. P.; Derynck, R.; Turbyville, T.; Boerckel, J. D.; Singh, S.; Kiessling, L. L.; Schwarz, T. L.; Varelas, X.; Wagner, F. F.; Kafri, R.; Eisinger-Mathason, T. S. K.; Carpenter, A. E.
10.1101/2021.07.29.454377 — bioinformatics — Posted on 2021-07-30
152 Sleep spindle dynamics suggest over-consolidation in post-traumatic stress disorder
van der Heijden, A. C.; Hofman, W. F.; de Boer, M.; Nijdam, M. J.; van Marle, H. J.; Jongedijk, R. J.; Olff, M.; Talamini, L. M.
10.1101/2021.07.29.453342 — neuroscience — Posted on 2021-07-30
155 SMGen: A generator of synthetic models of biochemical reaction networks
Riva, S. G.; Cazzaniga, P.; Nobile, M. S.; Spolaor, S.; Rundo, L.; Besozzi, D.; Tangherloni, A.
10.1101/2021.07.29.454343 — systems biology — Posted on 2021-07-30
157 Artificial Neural Networks for classification of single cell gene expression
Zhong, J.; Lyu, M.; Jin, H.; Cao, Z.; Chitkushev, L. T.; Zhang, G.; Keskin, D. B.; Brusic, V.
10.1101/2021.07.29.454293 — bioinformatics — Posted on 2021-07-30
161 A Kernel Method for Dissecting Genetic Signals in Tests of High-Dimensional Phenotypes
Solis-Lemus, C.; Holleman, A. M.; Todor, A.; Bradley, B.; Ressler, K. J.; Ghosh, D.; Epstein, M.
10.1101/2021.07.29.454336 — genomics — Posted on 2021-07-30
162 Modeling memory T cell states at single-cell resolution identifies in vivo state-dependence of eQTLs influencing disease
Nathan, A.; Asgari, S.; Ishigaki, K.; Amariuta, T.; Luo, Y.; Beynor, J. I.; Baglaenko, Y.; Suliman, S.; Price, A.; Lecca, L.; Murray, M. B.; Moody, D. B.; Raychaudhuri, S.
10.1101/2021.07.29.454316 — genetics — Posted on 2021-07-30
163 Across-population genomic prediction in grapevine opens up promising prospects for breeding
Brault, C.; Segura, V.; This, P.; Le Cunff, L.; Flutre, T.; Francois, P.; Pons, T.; Peros, J.-P.; Doligez, A.
10.1101/2021.07.29.454290 — genetics — Posted on 2021-07-30
167 Drivers of phylogenetic structure in Amazonian freshwater fish assemblages
Salgueiro Ribeiro, L.; Cassemiro, F.; Albert, J.; Frederico, R. G.; Hidalgo, M.; Hugueny, B.; Jezequel, C.; Ortega, H.; Tedesco, P.; Torrente-Vilara, G.; Zuanon, J.; Oberdorff, T.; Dias, M. S.
10.1101/2021.07.29.454320 — ecology — Posted on 2021-07-30
174 Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry
Kastenhuber, E. R.; Jaimes, J. A.; Johnson, J. L.; Mercadante, M.; Muecksch, F.; Weisblum, Y.; Bram, Y.; Schwartz, R. E.; Whittaker, G. R.; Cantley, L. C.
10.1101/2021.03.31.437960 — microbiology — Posted on 2021-07-30
175 Phosphorylation of PNKP mediated by CDKs promotes end-processing of Okazaki fragments during DNA replication
Tsukada, K.; Imamura, R.; Saikawa, K.; Saito, M.; Kase, N.; Miyake, T.; Ishiai, M.; Matsumoto, Y.; Shimada, M.
10.1101/2021.07.29.452278 — molecular biology — Posted on 2021-07-30
176 TNF-α levels in respiratory samples are associated with SARS-CoV-2 infection.
Pereson, M. J.; Badano, M. N.; Aloisi, N.; Chuit, R.; Braco, M. M.; Bare, P.
10.1101/2021.07.12.452071 — immunology — Posted on 2021-07-30
177 A cationic motif in Engrailed-2 homeoprotein controls its internalization via selective cell-surface glycosaminoglycans interactions
CARDON, S.; BOLBACH, G.; HERVIS, Y. P.; LOPIN-BON, C.; JACQUINET, J.-C.; ILLIEN, F.; Walrant, A.; RAVAULT, D.; HE, B.; Molina, L.; BURLINA, F.; LEQUIN, O.; JOLIOT, A.; CARLIER, L.; SAGAN, S.
10.1101/2021.07.29.454375 — biochemistry — Posted on 2021-07-30
179 A cohesin traffic pattern genetically linked to gene regulation
Valton, A.-L.; Venev, S. V.; Mair, B.; Khokhar, E.; Tong, A. H.; Usaj, M.; Chan, K. S.; Pai, A.; Moffat, J.; Dekker, J.
10.1101/2021.07.29.454218 — genomics — Posted on 2021-07-30
180 Crocosphaera as a major consumer of fixed nitrogen despite its capability of nitrogen fixation
Masuda, T.; Inomura, K.; Kodama, T.; Shiozaki, T.; Kitajima, S.; Armin, G.; Matsui, T.; Suzuki, K.; Takeda, S.; Prasil, O.; Furuya, K.
10.1101/2021.07.28.454264 — microbiology — Posted on 2021-07-30
181 Viruses of Asgard archaea
Medvedeva, S.; Sun, J.; Yutin, N.; Koonin, E. V.; Nunoura, T.; Rinke, C.; Krupovic, M.
10.1101/2021.07.29.453957 — microbiology — Posted on 2021-07-30
182 The transcriptional cofactor IRF2BP2 plays a key role in T cell homeostasis and Treg cell expansion
Mognol, G. P.; Oliveira-Vieira, B.; Pinheiro-Rosa, N.; Peixoto, B. C.; Boroni, M.; Gonzalez-Avalos, E.; Secca, C.; Bandukwala, H.; Faria, A. M. C.; Rao, A.; Viola, J. P. B.
10.1101/2021.07.29.454283 — immunology — Posted on 2021-07-30
185 The sensory code within sense of time
Reinartz, S.; Fassihi, A.; Paz, L.; Pulecchi, F.; Gigante, M.; Diamond, M. E.
10.1101/2021.07.29.454157 — neuroscience — Posted on 2021-07-30
186 Widespread nociceptive maps in the human neonatal somatosensory cortex
Jones, L.; Verriotis, M.; Cooper, R.; Laudiano-Dray, M.; Rupawala, M.; Meek, J.; Fabrizi, L.; Fitzgerald, M.
10.1101/2021.07.29.454164 — neuroscience — Posted on 2021-07-30
188 A multi-omics study to investigate tacrolimus nephrotoxicity mechanisms
AOUAD, H.; FAUCHER, Q.; SAUVAGE, F.-L.; PINAULT, E.; BARROT, C.-C.; ARNION, H.; MARQUET, P.; ESSIG, M.
10.1101/2021.07.29.454229 — pharmacology and toxicology — Posted on 2021-07-30
189 Determining the stability of genome-wide factors in BMI between ages 40 to 69 years.
Gillespie, N. A.; Gentry, A. E.; Kirkpatrick, R. M.; Maes, H. H.; Reynolds, C. A.; Mathur, R.; Kendler, K. S.; Peterson, R. S.; Webb, B. T.
10.1101/2021.07.28.454172 — genetics — Posted on 2021-07-30
190 A multimodal neuroprosthetic interface to record, modulate and classify electrophysiological correlates of cognitive function
Habelt, B.; Wirth, C.; Afanasenkau, D.; Mihaylova, L.; Winter, C.; Arvaneh, M.; Minev, I.; Bernhardt, N.
10.1101/2021.07.29.454271 — neuroscience — Posted on 2021-07-30
193 Age-Related Differences in Ventral Striatal and Default Mode Network Function During Reciprocated Trust
Fareri, D. S.; Hackett, K.; Tepfer, L. J.; Kelly, V. A.; Henninger, N.; Reeck, C.; Giovannetti, T.; Smith, D. V.
10.1101/2021.07.29.454071 — neuroscience — Posted on 2021-07-30
194 Functional coupling of TRPM2 and NMDARs exacerbates excitotoxicity in ischemic brain injury
Zong, P.; Feng, J.; Yue, Z.; Wu, G.; Sun, B.; He, Y.; Miller, B.; Yu, A. S.; Su, Z.; Mori, Y.; Xie, J.; Yue, L.
10.1101/2021.07.29.454247 — neuroscience — Posted on 2021-07-30
195 A comparative study between state-of-the-art MRI deidentification and AnonyMI, a new method combining re-identification risk reduction and geometrical preservation
Mikulan, E.; Russo, S.; Zauli, F. M.; d'Orio, P.; Parmigiani, S.; Favaro, J.; Knight, W.; Squarza, S.; Perri, P.; Cardinale, F.; Avanzini, P.; Pigorini, A.
10.1101/2021.07.30.454335 — neuroscience — Posted on 2021-07-30
196 Coherent mapping of position and head direction across auditory and visual cortex
Mertens, P. E. C.; Marchesi, P.; Oude Lohuis, M. N.; Krijger, Q.; Pennartz, C. M. A.; Lansink, C. S.
10.1101/2021.07.30.452931 — neuroscience — Posted on 2021-07-30
199 Cryptic genetic structure and copy-number variation in the ubiquitous forest symbiotic fungus Cenococcum geophilum
Dauphin, B.; de Freitas Pereira, M.; Kohler, A.; Grigoriev, I.; Barry, K.; Na, H.; Amirebrahimi, M.; Lipzen, A.; Martin, F.; Peter, M.; Croll, D.
10.1101/2021.07.29.454341 — genomics — Posted on 2021-07-30
201 Alpha oscillations shape sensory representation and perceptual sensitivity
Zhou, Y. J.; Iemi, L.; Schoffelen, J.-M.; de Lange, F. P.; Haegens, S.
10.1101/2021.02.02.429418 — neuroscience — Posted on 2021-07-30
202 The temperature-regulated DEAD-box RNA helicase CrhR interactome: Autoregulation and photosynthesis-related transcripts
Migur, A.; Heyl, F.; Fuss, J.; Srikumar, A.; Huettel, B.; Steglich, C.; Prakash, J. S. S.; Reinhardt, R.; Backofen, R.; Owttrim, G. W.; Hess, W. R.
10.1101/2021.03.26.437152 — plant biology — Posted on 2021-07-30
204 The role of the atypical chemokine receptor CCRL2 in myelodysplastic syndrome and secondary acute myeloid leukemia
KARANTANOS, T.; Teodorescu, P.; Perkins, B.; Christodolou, I.; Esteb, C.; Varadhan, R.; Helmenstine, E.; Rajkhowa, T.; Paun, B.; Bonifant, C.; Dalton, W. B.; Gondek, L. P.; Moliterno, A. R.; Levis, M. J.; Ghiaur, G.; Jones, R. J.
10.1101/2021.07.29.454394 — cancer biology — Posted on 2021-07-30
205 Investigating molecular crowding during cell division in budding yeast with FRET
Lecinski, S.; Shepherd, J.; Frame, L.; Hayton, I.; MacDonald, C.; Leake, M. C.
10.1101/2021.07.29.454334 — biophysics — Posted on 2021-07-30
206 SF3B1 promotes tumor malignancy through splicing-independent co-activation of HIF1α
Simmler, P.; Cortijo, C.; Koch, L. M.; Galliker, P.; Schaefer, M.; Angori, S.; Bolck, H. A.; Mueller, C.; Vukolic, A.; Mirtschink, P.; Christinat, Y.; Davidson, N. R.; Lehmann, K.-V.; Pellegrini, G.; Pauli, C.; Lenggenhager, D.; Guccini, I.; Ringel, T.; Hirt, C.; Raetsch, G.; Moch, H.; Stoffel, M.; Schwank, G.
10.1101/2020.11.10.376780 — cell biology — Posted on 2021-07-30
208 In vivo KRAS G12D/V Degradation Mediated by CANDDY Using a Modified Proteasome Inhibitor
Imanishi, S.; Huang, L.; Itakura, S.; Ishizaka, M.; Iwasaki, Y.; Yamaguchi, T.; Miyamoto-Sato, E.
10.1101/2021.04.23.441075 — molecular biology — Posted on 2021-07-30
212 Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers
Louros, N. N.; Ramakers, M.; Michiels, E.; Konstantoulea, K.; Morelli, C.; Garcia, T.; D'Haeyer, S.; Goossens, V.; Audenaert, D.; Rousseau, F.; Schymkowitz, J.
10.1101/2021.06.04.447096 — biophysics — Posted on 2021-07-30
213 Towards a comprehensive delineation of white matter tract-related deformation
Zhou, Z.; Li, X.; Liu, Y.; Fahlstedt, M.; Georgiadis, M.; Zhan, X.; Raymond, S. J.; Grant, G.; Kleiven, S.; Camarillo, D.; Zeineh, M. M.
10.1101/2021.04.13.439136 — bioengineering — Posted on 2021-07-30
214 Phenotypic architecture of sociality and its associated genetic polymorphisms in zebrafish
Oliveira, R. F.; Goncalves, C.; Kareklas, K.; Teles, M. C.; Varela, S. A. M.; Costa, J.; Leite, R. B.; Paixao, T.
10.1101/2021.07.29.454277 — animal behavior and cognition — Posted on 2021-07-30
215 A burst of regulatory and protein innovation at the origin of placental mammals drove the emergence of placenta and underpins divergent early pregnancy strategies in modern mammals.
Taylor, A. S.; Tinning, H.; Ovchinnikov, V.; Smith, W.; Pullinger, A. L.; Sutton, R. A.; Constantinides, B.; Wang, D.; Forde, N.; O'Connell, M. J.
10.1101/2021.07.22.453388 — evolutionary biology — Posted on 2021-07-29
219 Model-based inference of neutralizing antibody avidities against influenza virus
Linnik, J.; Syedbasha, M.; Hollenstein, Y.; Halter, J.; Egli, A.; Stelling, J.
10.1101/2020.10.05.326215 — immunology — Posted on 2021-07-29
223 Lignin-based resistance to Cuscuta campestris parasitism in Heinz resistant tomato cultivars
Jhu, M.-Y.; Farhi, M.; Wang, L.; Philbrook, R. N.; Belcher, M. S.; Nakayama, H.; Zumstein, K. S.; Rowland, S. D.; Ron, M.; Shih, P. M.; Sinha, N. R.
10.1101/706861 — plant biology — Posted on 2021-07-29
232 Metal-Organic Framework Encapsulated Whole-Cell Vaccines Enhance Humoral Immunity against Bacterial Infection
Luzuriaga, M. A.; Herbert, F. C.; Brohlin, O.; Gadhvi, J.; Howlett, T.; Shahrivarkevishahi, A.; Wijesundara, Y. H.; Venkitapathi, S.; Veera, K.; Ehrman, R.; Benjamin, C. E.; Popal, S.; Burton, M. D.; Ingersoll, M. A.; De Nisco, N. J.; Gassensmith, J. J.
10.1101/2020.06.14.148452 — immunology — Posted on 2021-07-29
233 Reliability of Mouse Behavioural Tests of Anxiety: a Systematic Review and Meta-Analysis on the Effects of Anxiolytics.
Rosso, M.; Wirz, R.; Loretan, A. V.; Sutter, N. A.; Pereira da Cunha, C. T.; Jaric, I.; Würbel, H.; Voelkl, B.
10.1101/2021.07.28.454267 — neuroscience — Posted on 2021-07-29
234 Double nerve transfer to a single target muscle: experimental model in the upper extremity
Luft, M.; Klepetko, J.; Muceli, S.; Ibanez, J.; Tereshenko, V.; Festin, C.; Laengle, G.; Politikou, O.; Maierhofer, U.; Farina, D.; Aszmann, O. C.; Bergmeister, K. D.
10.1101/2021.07.09.451759 — neuroscience — Posted on 2021-07-29
237 Small extracellular vesicles from young mice prevent frailty and improve healthspan in old mice.
Sanz-Ros, J.; Mas-Bargues, C.; Monleon, D.; Dromant, M.; Derevyanko, A.; Guio-Carrion, A.; Roman-Dominguez, A.; Romero-Garcia, N.; Ingles, M.; Blasco, M. A.; Vina, J.; Borras, C.
10.1101/2021.07.29.454302 — physiology — Posted on 2021-07-29
238 ZBTB18 inhibits SREBP-dependent fatty acid synthesis by counteracting CTBPs and KDM1A/LSD1 activity in glioblastoma
Ferrarese, R.; Izzo, A.; Andrieux, G.; Lagies, S.; Bartmuss, J. P.; Masilamani, A. P.; Wasilenko, A.; Osti, D.; Faletti, S.; Schulzki, R.; Yuan, S.; Kling, E.; Ribecco, V.; Heiland, H. D.; Tholen, S. G.; Prinz, M.; Pelicci, G.; Kammerer, B.; Boerries, M.; Carro, M. S.
10.1101/2020.04.17.046268 — cancer biology — Posted on 2021-07-29
240 A Non-Canonical Raf Function Is Required for Dorsal-Ventral Patterning During Drosophila Embryogenesis
Tolwinski, N. S.; Lusk, J. B.; Chua, E. H. Z.; Kaur, P.; Sung, I. C. H.; Lim, W. K.; Lam, V. Y. M.; Harmston, N.
10.1101/2021.07.29.454294 — developmental biology — Posted on 2021-07-29
242 Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline
Graniel, J. V.; Bisht, K.; Friedman, A.; White, J.; Perkey, E.; Vanderbeck, A.; Moroz, A.; Carrington, L. J.; Brandstadter, J. D.; Allen, F.; Shami, A. N.; Thomas, P.; Crayton, A.; Manzor, M.; Mychalowych, A.; Chase, J.; Hammoud, S. S.; Keegan, C. E.; Maillard, I.; Nandakumar, J.
10.1101/2021.07.29.454392 — cell biology — Posted on 2021-07-29
243 Calcium-binding protein S100A6 interaction with VEGF receptors integrates signaling and trafficking pathways
Ponnambalam, S.; Bao, L.; Fearnley, G. W.; Lin, C.-C.; Odell, A. F.; Redondo, A. C.; Kinsella, G. K.; Findlay, J. B. C.; Ladbury, J. E.; Harrison, M.
10.1101/2021.07.29.454311 — cell biology — Posted on 2021-07-29
244 METTL18-mediated histidine methylation on RPL3 modulates translation elongation for proteostasis maintenance
Matsuura-Suzuki, E.; Shimazu, T.; Takahashi, M.; Kotoshiba, K.; Suzuki, T.; Kashiwagi, K.; Sohtome, Y.; Akakabe, M.; Sodeoka, M.; Dohmae, N.; Ito, T.; Shinkai, Y.; Iwasaki, S.
10.1101/2021.07.29.454307 — molecular biology — Posted on 2021-07-29
248 TOR kinase controls shoot development by translational regulation of cytokinin catabolic enzymes
Janocha, D.; Pfeiffer, A.; Dong, Y.; Novak, O.; Strnad, M.; Ryabova, L.; Lohmann, J. U.
10.1101/2021.07.29.454319 — plant biology — Posted on 2021-07-29
250 Semaphorin 3C exacerbates liver fibrosis
De Angelis Rigotti, F.; Wiedmann, L.; Hubert, M. O.; Vacca, M.; Hasan, S. S.; Moll, I.; Carvajal, S.; Jimenez, W.; Starostecka, M.; Billeter, A. T.; Müller-Stich, B.; Wolff, G.; Ekim-Üstünel, B.; Herzig, S.; Mogler, C.; Fischer, A.; Rodriguez-Vita, J.
10.1101/2021.07.29.454292 — pathology — Posted on 2021-07-29
251 Cellular organization in lab-evolved and extant multicellular species obeys a maximum entropy law
Day, T. C.; Höhn, S. S.; Zamani-Dahaj, S. A.; Yanni, D.; Burnetti, A.; Pentz, J.; Honerkamp-Smith, A. R.; Wioland, H.; Sleath, H. R.; Ratcliff, W. C.; Goldstein, R. E.; Yunker, P. J.
10.1101/2021.07.29.454238 — biophysics — Posted on 2021-07-29
252 Proteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteins
Healy, M. D.; Sacharz, J.; McNally, K. E.; McConville, C.; Hall, R. J.; Chilton, M.; Cullen, P. J.; Mobli, M.; Ghai, R.; Stroud, D. A.; Collins, B.
10.1101/2021.07.29.454387 — biochemistry — Posted on 2021-07-29
254 Cryptic genetic structure and copy-number variation in the ubiquitous forest symbiotic fungus Cenococcum geophilum
Dauphin, B.; de Freitas Pereira, M.; Kohler, A.; Grigoriev, I.; Barry, K.; Na, H.; Amirebrahimi, M.; Lipzen, A.; Martin, F.; Peter, M.; Croll, D.
10.1101/2021.07.29.454341 — genomics — Posted on 2021-07-29
255 Targeted resurrection of chromosomal arm 1RS in two elite wheat lines with 1BL/1RS translocation for improved end-use quality
Kaur, R.; Dhillon, G. S.; Kaur, A.; Kaur, S.; Kaur, P.; Kaur, D.; Kumar, A.; Singh, R.; Mavi, G. S.; Grewal, S. K.; Chhuneja, P.; Kaur, S.
10.1101/2021.07.29.454297 — genetics — Posted on 2021-07-29
258 Systemic antibody-oligonucleotide delivery to the central nervous system ameliorates mouse models of spinal muscular atrophy
Hammond, S. M.; Abendroth, F.; Goli, L.; Burrell, M.; Thom, G.; Gurrell, I.; Stoodley, J.; Ahlskog, N.; Gait, M. J.; Wood, M.; Webster, C.
10.1101/2021.07.29.454272 — molecular biology — Posted on 2021-07-29
260 m6A-mediated Cell-cell Communication Controls Planarian Regeneration
Cui, G.; Zhou, J.-Y.; Ge, X.-Y.; Sun, B.-F.; Song, G.-G.; Wang, X.; Wang, X.-Z.; Zhang, R.; Wang, H.; Jing, Q.; Zhao, Y.; Koziol, M.; Zeng, A.; Zhang, W.; Han, D.; Yang, Y.; Yang, Y.-G.
10.1101/2021.07.29.454253 — molecular biology — Posted on 2021-07-29
266 HGFAC is a ChREBP Regulated Hepatokine that Enhances Glucose and Lipid Homeostasis
Sargsyan, A.; Doridot, L.; Hannou, S. A.; Tong, W.; Srinivasan, H.; Ivison, R.; Monn, R.; Kou, H. H.; Haldeman, J. M.; Arlotto, M.; White, P. J.; Grimsrud, P. A.; Astapova, I.; Tsai, L.; Herman, M. A.
10.1101/2021.07.29.454308 — physiology — Posted on 2021-07-29
268 Increasing cell size remodels the proteome and promotes senescence
Lanz, M. C.; Zatulovskiy, E.; Swaffer, M. P.; Zhang, L.; Zhang, S.; You, D. S.; Marinov, G. K.; McAlpine, P.; Elias, J. E.; Skotheim, J. M.
10.1101/2021.07.29.454227 — cell biology — Posted on 2021-07-29
269 Vimentin Intermediate Filaments and Filamentous Actin Form Unexpected Interpenetrating Networks That Redefine the Cell Cortex
Wu, H.; Shen, Y.; Sivagurunathan, S.; Weber, M. S.; Adam, S. A.; Shin, J. H.; Fredberg, J. J.; Medalia, O.; Goldman, R.; Weitz, D. A.
10.1101/2021.07.29.454155 — cell biology — Posted on 2021-07-29
271 Human brain anatomy reflects separable genetic and environmental components of socioeconomic status
Kweon, H.; Aydogan, G.; Dagher, A.; Bzdok, D.; Ruff, C. C.; Nave, G.; Farah, M. J.; Koellinger, P. D.
10.1101/2021.07.28.454131 — neuroscience — Posted on 2021-07-29
276 The META tool optimizes metagenomic analyses across sequencing platforms and classifiers.
Player, R. A.; Aguinaldo, A. M.; Merritt, B. B.; Maszkiewicz, L. N.; Adeyemo, O. E.; Forsyth, E. R.; Verratti, K. J.; Chee, B. W.; Grady, S. L.; Bradburne, C. E.
10.1101/2021.07.29.454031 — bioinformatics — Posted on 2021-07-29
277 Placental gene expression-based cell type deconvolution: Cell proportions drive preeclampsia gene expression differences
Campbell, K. A.; Colacino, J. A.; Puttabyatappa, M.; Dou, J.; Elkin, E. R.; Hammoud, S. S.; Domino, S. E.; Dolinoy, D. C.; Goodrich, J. M.; Loch-Caruso, R.; Padmanabhan, V.; Bakulski, K. M.
10.1101/2021.07.29.454041 — developmental biology — Posted on 2021-07-29
283 Optimizing large organ scale micro computed tomography imaging in pig and human hearts using a novel air-drying technique
Pallares-Lupon, N.; Ramlugun, G. S.; Ozenne, V.; Duchateau, J.; Delgove, A.; Bayer, J. D.; Moreno, A.; Constantin, M.; Gerneke, D.; Sands, G. B.; Trew, M. L.; Hocini, M.; Haissaguerre, M.; Vigmond, E. J.; Quesson, B.; Bernus, O.; Walton, R. D.
10.1101/2021.07.29.454121 — physiology — Posted on 2021-07-29
284 Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing
Frey, N.; Tortola, L.; Egli, D.; Janjuha, S.; Marquart, K. F.; Rothgangl, T.; Ampenberger, F.; Kopf, M.; Schwank, G.
10.1101/2021.07.29.453937 — cancer biology — Posted on 2021-07-29
286 Dual Roles for Nuclear RNAi Argonautes in C. elegans Dosage Compensation
Davis, M. B.; Chawla, B.; Jash, E.; Tushman, L. E.; Haines, R. A.; Csankovszki, G.
10.1101/2021.07.29.454039 — genetics — Posted on 2021-07-29
288 Stabilizing selection shapes variation in phenotypic plasticity
Becker, D.; Barnard-Kubow, K.; Porter, R.; Edwards, A.; Voss, E.; Beckerman, A. P.; Bergland, A. O.
10.1101/2021.07.29.454146 — evolutionary biology — Posted on 2021-07-29
294 Heme-stress activated NRF2 signaling skews fate trajectories of bone marrow cells from dendritic cells towards red pulp-like macrophages
Vallelian, F.; Buzzi, R. M.; Pfefferle, M.; Yalamanoglu, A.; Wassmer, A.; Gentinetta, T.; Hansen, K.; Humar, R.; Schulthess, N.; Schaer, D. J.
10.1101/2021.07.29.454342 — immunology — Posted on 2021-07-29
295 Mutant huntingtin crosses the neuromuscular junction and causes transmission-selective pathological alterations in huntingtin expressing myotubes
Dinamarca Ceballos, M.; Colombo, L.; Brykczynska, U.; Grimm, A.; Tousiaki, E. N.; Fruh, I.; Hossain, I.; Gabriel, D.; Eckert, A.; Mueller, M.; Pecho-Vrieseling, E.
10.1101/2021.07.28.454044 — neuroscience — Posted on 2021-07-29
297 Photoacoustic-MR Images Registration Based on Co-Sparse Analysis Model to Compensate for Brain Shift
Farnia, P.; Makkiabadi, B.; Alimohammadi, M.; Najafzadeh, E.; Basij, M.; Yan, Y.; Ahmadian, A.; Mehrmohammadi, M.
10.1101/2021.07.28.453095 — bioengineering — Posted on 2021-07-29
298 High-resolution protein fragment interactions using AVA-Seq on a human reference set
Ramadan, S.; Aleksic, J.; Al-Thani, N. M.; Mohamoud, Y. A.; Hill, D. E.; Malek, J. A.
10.1101/2021.07.28.454266 — genomics — Posted on 2021-07-29
299 SARS-CoV-2 exposure in wild white-tailed deer (Odocoileus virginianus)
Chandler, J. C.; Bevins, S. N.; Ellis, J. W.; Linder, T. J.; Tell, R. M.; Jenkins-Moore, M.; Root, J. J.; Lenoch, J. B.; Robbe-Austerman, S.; DeLiberto, T. J.; Gidlewski, T.; Torchetti, M. K.; Shriner, S. A.
10.1101/2021.07.29.454326 — microbiology — Posted on 2021-07-29
300 Antibody Evolution after SARS-CoV-2 mRNA Vaccination
Cho, A.; Muecksch, F.; Schaefer-Babajew, D.; Wang, Z.; Finkin, S.; Gaebler, C.; Ramos, V.; Cipolla, M.; Agudelo, M.; Bednarski, E.; DaSilva, J.; Shimeliovich, I.; Dizon, J.; Daga, M.; Millard, K.; Turroja, M.; Schmidt, F.; Zhang, F.; Ben Tanfous, T.; Jankovic, M.; Oliveira, T.; Gazumyan, A.; Caskey, M.; Bieniasz, P. D.; Hatziioannou, T.; Nussenzweig, M. C.
10.1101/2021.07.29.454333 — immunology — Posted on 2021-07-29
301 Structural basis for recognition of two HLA-A2-restricted SARS-CoV-2 spike epitopes by public and private T cell receptors
Wu, D.; Kolesnikov, A.; Yin, R.; Guest, J. D.; Gowthaman, R.; Shmelev, A.; Serdyuk, Y.; Efimov, G. A.; Pierce, B. G.; Mariuzza, R. A.
10.1101/2021.07.28.454232 — immunology — Posted on 2021-07-29
302 Inferring cell-cell interactions from pseudotime ordering of scRNA-Seq data
Li, D.; Velazquez, J. J.; Ding, J.; Hislop, J.; Ebrahimkhani, M. R.; Bar-Joseph, Z.
10.1101/2021.07.28.454054 — bioinformatics — Posted on 2021-07-29
303 The economical lifestyle of CPR bacteria in groundwater allows little preference for environmental drivers
Chaudhari, N. M.; Overholt, W. A.; Figueroa-Gonzalez, P. A.; Taubert, M.; Bornemann, T. L. V.; Probst, A. J.; Hölzer, M.; Marz, M.; Küsel, K.
10.1101/2021.07.28.454184 — microbiology — Posted on 2021-07-29
304 Machine learning uncovers a data-driven transcriptional regulatory network for the Crenarchaeal thermoacidophile Sulfolobus acidocaldarius
Chauhan, S. M.; Poudel, S.; Rychel, K.; Lamoureux, C.; Yoo, R.; Al Bulushi, T.; Yuan, Y.; Palsson, B.; Sastry, A. V.
10.1101/2021.07.28.454237 — systems biology — Posted on 2021-07-29
306 Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis
Ji, h.; Jin, Y.; Zhao, Q.; Zhu, W.; Feng, Y.; Xiao, T.; Zhang, P.; Jiang, L.; Hou, Y.; Guo, C.; Huang, H.; Chen, Y.; Tong, X.; Cao, J.; Zhu, X.; Qin, J.; Gao, D.; Liu, X.-y.; Zhang, H.; Chen, L.; Thomas, R. K.; Wong, K.-K.; Wang, Y.; Hu, L.
10.1101/2021.07.28.454244 — cancer biology — Posted on 2021-07-29
307 A Topological Data Analytic Approach for Discovering Biophysical Signatures in Protein Dynamics
Tang, W. S.; da Silva, G. M.; Kirveslahti, H.; Skeens, E.; Feng, B.; Sudijono, T.; Yang, K. K.; Mukherjee, S.; Rubenstein, B.; Crawford, L.
10.1101/2021.07.28.454240 — biophysics — Posted on 2021-07-29
308 Automated Reconstruction of Whole-Embryo Cell Lineages by Learning from Sparse Annotations
Malin-Mayor, C.; Hirsch, P.; Guignard, L.; McDole, K.; Wan, Y.; Lemon, W. C.; Keller, P. J.; Preibisch, S.; Funke, J.
10.1101/2021.07.28.454016 — bioinformatics — Posted on 2021-07-29
312 Hormonal contraceptives alter amphetamine place preference and responsivity in the intact female rat.
Hilz, E. N.; Olvera, M.; Jun, D. S.; Chadha, M.; Gillette, R.; Monfils, M. H.; Gore, A. C.; Lee, H. J.
10.1101/2021.07.28.454029 — animal behavior and cognition — Posted on 2021-07-29
314 The swine spatiotemporal H3K27ac spectrum provides novel resources for exploring gene regulation related to complex traits and fundamental biological process
Huang, L.; Zhu, Y.; Zhou, Z.; Huang, T.; Zhang, Z.; Li, W.; Ling, Z.; Jiang, T.; Yang, J.; Yang, S.; Xiao, Y.; Charlier, C.; Georges, M.; Yang, B.
10.1101/2021.07.28.454245 — genomics — Posted on 2021-07-29
316 Evolutionary dynamics of asexual hypermutators adapting to a novel environment
Ho, W.-C.; Behringer, M. G.; Miller, S. F.; Gonzales, J.; Nguyen, A.; Allahwerdy, M.; Boyer, G. F.; Lynch, M.
10.1101/2021.07.28.454222 — evolutionary biology — Posted on 2021-07-29
317 A systematic review and meta-analysis of the potential non-human animal reservoirs and arthropod vectors of the Mayaro virus
Celone, M.; Okech, B.; Han, B. A.; Forshey, B.; Anyamba, A.; Dunford, J.; Rutherford, G.; Mita Mendoza, N. K.; Estallo, E. L.; Khouri, R.; de Siqueira, I. C.; Pollett, S.
10.1101/2021.07.28.454243 — ecology — Posted on 2021-07-29
319 PLB-985 neutrophil-like cells release antifungal extracellular vesicles against the human-pathogenic fungus Aspergillus fumigatus
Rafiq, M.; Rivieccio, F.; Zimmermann, A.-K.; Visser, C.; Bruch, A.; Krüger, T.; Gonzalez, K.; Kniemeyer, O.; Blango, M. G.; Brakhage, A. A.
10.1101/2021.07.28.454178 — microbiology — Posted on 2021-07-29
320 Systems analysis of immune responses to attenuated P. falciparum malaria sporozoite vaccination reveals excessive inflammatory signatures correlating with impaired immunity
Du, Y.; Hertoghs, N.; Carnes, J.; McDermott, S. M.; Neal, M. L.; Schwedhelm, K. V.; McElrath, M. J.; De Rosa, S. C.; Aitchison, J. D.; Stuart, K. D.
10.1101/2021.07.28.454252 — immunology — Posted on 2021-07-29
321 Multi-tier mechanics control stromal adaptations in swelling lymph nodes
Assen, F. P.; Hons, M.; Hauschild, R.; Shamipour, S.; Abe, J.; Kaufmann, W. A.; Costanzo, T.; Krens, G.; Brown, M.; Ludewig, B.; Hippenmeyer, S.; Stein, J. V.; Heisenberg, C.-P.; Hannezo, E.; Luther, S. A.; Sixt, M.
10.1101/2021.07.28.454217 — immunology — Posted on 2021-07-29
322 TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration
Xie, M.; Liu, Y. U.; Zhao, S.; Zhang, L.; Bosco, D. B.; Pang, Y.-P.; Zhong, J.; Sheth, U.; Martens, Y. A.; Zhao, N.; Liu, C.-C.; Zhuang, Y.; Wang, L.; Dickson, D. W.; Mattson, M. P.; Bu, G.; Wu, L.-J.
10.1101/2021.07.28.454242 — neuroscience — Posted on 2021-07-29
323 Early Life Adversity in Male Mice Sculpts Reward Circuits.
Wendel, K. M.; Short, A. K.; Noarbe, B. P.; Haddad, E.; Palma, A. M.; Yassa, M. A.; Baram, T. Z.; Obenaus, A.
10.1101/2021.07.28.454015 — neuroscience — Posted on 2021-07-29
326 The timescale and magnitude of aperiodic activity decreases with cortical depth in humans, macaques and mice
Halgren, M.; Kang, R.; Voytek, B.; Ulbert, I.; Fabo, D.; Eross, L. G.; Wittner, L.; Madsen, J.; Doyle, W. K.; Devinsky, O.; Halgren, E.; Harnett, M. T.; Cash, S. S.
10.1101/2021.07.28.454235 — neuroscience — Posted on 2021-07-29
327 Functional connectomics spanning multiple areas of mouse visual cortex
MICrONs Consortium, ; Bodor, A. L.; Halageri, A.; Sterling, A.; Tolias, A. S.; Ramos, A.; Nehoran, B.; Silverman, B.; Celii, B.; Smith, C. L.; Schneider-Mizell, C. M.; Jordan, C.; Xu, C.; Papadopoulos, C.; Gamlin, C.; Kapner, D.; Bumbarger, D. J.; Brittain, D.; Yatsenko, D.; Walker, E. Y.; Miranda, E.; Froudarakis, E.; Mitchell, E.; Cobos, E.; Sinz, F. H.; Ye, F.; Collman, F.; Mahalingam, G.; Williams, G.; Seung, H. S.; Bae, J. A.; Reimer, J.; Hebditch, J.; Gager, J.; Wu, J.; Buchanan, J.; Kuehner, K.; Li, K.; Lee, K.; Willie, K.; Elabbady, L.; Baptiste, M.; Castro, M. A.; Takeno, M.; Moore,
10.1101/2021.07.28.454025 — neuroscience — Posted on 2021-07-29
335 An atlas of healthy and injured cell states and niches in the human kidney
Lake, B. B.; Menon, R.; Winfree, S.; Hu, Q.; Ferreira, R. M.; Kalhor, K.; Barwinska, D.; Otto, E. A.; Ferkowicz, M.; Diep, D.; Plongthongkum, N.; Knoten, A.; Urata, S.; Naik, A. S.; Eddy, S.; Zhang, B.; Wu, Y.; Salamon, D.; Williams, J. C.; Wang, X.; Balderrama, K. S.; Hoover, P.; Murray, E.; Vijayan, A.; Chen, F.; Waikar, S. S.; Rosas, S.; Wilson, F. P.; Palevsky, P. M.; Kiryluk, K.; Sedor, J. R.; Toto, R. D.; Parikh, C.; Kim, E. H.; Macosko, E. Z.; Kharchenko, P. V.; Gaut, J. P.; Hodgin, J. B.; Eadon, M. T.; Dagher, P. C.; El-Achkar, T. M.; Zhang, K.; Kretzler, M.; Jain, S.; KPMP Consortium,
10.1101/2021.07.28.454201 — genomics — Posted on 2021-07-29
342 Sensory computations in the cuneate nucleus of macaques
Suresh, A. K.; Greenspon, C. M.; He, Q.; Rosenow, J. M.; Miller, L. E.; Bensmaia, S. J.
10.1101/2021.07.28.454185 — neuroscience — Posted on 2021-07-29
343 Developmental coupling of cerebral blood flow and fMRI fluctuations in youth
Baller, E. B.; Valcarcel, A. M.; Adebimpe, A.; Alexander-Bloch, A.; Cui, Z.; Gur, R. C.; Gur, R. E.; Larsen, B. L.; Linn, K. A.; O'Donnell, C. M.; Pines, A. R.; Raznahan, A.; Roalf, D. R.; Sydnor, V. J.; Tapera, T. M.; Tisdall, M. D.; Vandekar, S.; Xia, C. H.; Detre, J. A.; Shinohara, R. T.; Satterthwaite, T. D.
10.1101/2021.07.28.454179 — neuroscience — Posted on 2021-07-29
344 Chemogenetic Inhibition of Corticostriatal Circuits Reduces Cued Reinstatement of Methamphetamine Seeking
Kearns, A. M.; Siemsen, B.; Hopkins, J.; Weber, R.; Scofield, M.; Peters, J.; Reichel, C. M.
10.1101/2021.07.28.453847 — neuroscience — Posted on 2021-07-29
345 Pharmacokinetics and biodistribution of extracellular vesicles administered intravenously and intranasally to Macaca nemestrina
Driedonks, T.; Jiang, L.; Carlson, B.; Han, Z.; Liu, G.; Queen, S. E.; Shirk, E. N.; Gololobova, O.; Nyberg, L.; Lima, G.; Schonvisky, K.; Stover, M.; Guerrero-Martin, S.; Richardson, M. R.; Smith, B.; Lai, C. P.; Izzi, J. M.; Hutchinson, E. K.; Pate, K. A.; Witwer, K. W.
10.1101/2021.07.28.454192 — pharmacology and toxicology — Posted on 2021-07-29
348 In situ cryo-electron tomography reveals local cellular machineries for axon branch development
Nedozralova, H.; Basnet, N.; Ibiricu, I.; Bodakuntla, S.; Biertumpfel, C.; Mizuno, N.
10.1101/2021.07.28.454169 — neuroscience — Posted on 2021-07-29
350 Muscarinic receptors mediate motivation via preparatory neural activity in humans
Grogan, J. P.; Raemaekers, M.; van Swieten, M. M. H.; Green, A. L.; Gillies, M. J.; Manohar, S. G.
10.1101/2021.07.28.454154 — neuroscience — Posted on 2021-07-29
351 Patient-derived gene and protein expression signatures of NGLY1 deficiency
Rauscher, B.; Mueller, W. F.; Clauder-Muenster, S.; Jakob, P.; Islam, M. S.; Sun, H.; Ghidelli-Disse, S.; Boesche, M.; Bantscheff, M.; Pflaumer, H.; Collier, P.; Haase, B.; Chen, S.; Wang, G.; Benes, V.; Snyder, M.; Drewes, G.; Steinmetz, L. M.
10.1101/2021.07.28.453930 — systems biology — Posted on 2021-07-29
352 Patient-specific Boolean models of signaling networks guide personalized treatments
Montagud, A.; Beal, J.; Tobalina, L.; Traynard, P.; Subramanian, V.; Szalai, B.; Alföldi, R.; Puskas, L.; Valencia, A.; Barillot, E.; Saez-Rodriguez, J.; Calzone, L.
10.1101/2021.07.28.454126 — systems biology — Posted on 2021-07-29
355 4D live-cell imaging of microgametogenesis in the human malaria parasite Plasmodium falciparum
Yahiya, S.; Jordan, S.; Smith, H. X.; Gaboriau, D. C. A.; Famodimu, M. T.; Dahalan, F. A.; Churchyard, A.; Ashdown, G. W.; Baum, J.
10.1101/2021.07.28.454129 — microbiology — Posted on 2021-07-29
356 Brain connectivity-based prediction of real-life creativity is mediated by semantic memory structure
Ovando-Tellez, M.; Kenett, Y. N.; Benedek, M.; Bernard, M.; Belo, J.; Beranger, B.; Bieth, T.; VOLLE, E.
10.1101/2021.07.28.453991 — neuroscience — Posted on 2021-07-29
359 Reliability of Mouse Behavioural Tests of Anxiety: a Systematic Review and Meta-Analysis on the Effects of Anxiolytics.
Rosso, M.; Wirz, R.; Loretan, A. V.; Sutter, N. A.; Pereira da Cunha, C. T.; Jaric, I.; Würbel, H.; Voelkl, B.
10.1101/2021.07.28.454267 — neuroscience — Posted on 2021-07-29
363 Knowledge Graph-based Recommendation Framework Identifies Novel Drivers of Resistance in EGFR mutant Non-small Cell Lung Cancer
Gogleva, A.; Polychronopoulos, D.; Pfeifer, M.; Poroshin, V.; Ughetto, M.; Sidders, B.; Dry, J.; Ahdesmaki, M.; McDermott, U.; Papa, E.; Bulusu, K.
10.1101/2021.07.23.453506 — cancer biology — Posted on 2021-07-29
365 CLEMSite, a software for automated phenotypic screens using light microscopy and FIB-SEM
Serra Lleti, J. M.; Steyer, A. M.; Schieber, N. L.; Neumann, B.; Tischer, C.; Hilsenstein, V.; Holtstrom, M.; Unrau, D.; Kirmse, R.; Lucocq, J. M.; Pepperkok, R.; Schwab, Y.
10.1101/2021.03.19.436113 — cell biology — Posted on 2021-07-29
367 Mapping drug-microenvironment-genetic interplay in CLL reveals trisomy 12 as a modulator of microenvironmental signals
Bruch, P.-M.; Giles, H. A. R.; Kolb, C.; Herbst, S. A.; Becirovic, T.; Roider, T.; Lu, J.; Scheinost, S.; Wagner, L.; Hüllein, J.; Berest, I.; Kriegsmann, M.; Kriegsmann, K.; Zgorzelski, C.; Dreger, P.; Zaugg, J. B.; Müller-Tidow, C.; Zenz, T.; Huber, W.; Dietrich, S.
10.1101/2021.07.23.453514 — cancer biology — Posted on 2021-07-29
368 Symmetry and simplicity spontaneously emerge from the algorithmic nature of evolution
Johnston, I.; Dingle, K.; Greenbury, S. F.; Camargo, C. Q.; Doye, J. P. K.; Ahnert, S. E.; Louis, A. A.
10.1101/2021.07.28.454038 — evolutionary biology — Posted on 2021-07-29
369 Inhibition of Mul1-mediated ubiquitination promotes mitochondria-associated translation
Gao, Y.; Cardamone, M. D.; Kwan, J.; Hekman, R.; Orofino, J.; Lyons, S. M.; Emili, A.; Perissi, V.
10.1101/2021.07.28.454107 — cell biology — Posted on 2021-07-29
370 SYNAPTIC RELEASE POTENTIATION AT AGING AUDITORY RIBBON SYNAPSES
Peineau, T.; Belleudy, S.; pietropaolo, s.; bouleau, y.; Dulon, D.
10.1101/2020.05.15.097550 — neuroscience — Posted on 2021-07-29
371 Contribution of 3D genome topological domains to genetic risk of cancers
Jablonski, K. P.; Carron, L.; Mozziconacci, J.; Forne, T.; Hütt, M.-T.; Lesne, A.
10.1101/2021.07.26.453813 — genetics — Posted on 2021-07-29
372 PRDM9 losses in vertebrates are coupled to those of paralogs ZCWPW1 and ZCWPW2
Cavassim, M. I. A.; Baker, Z.; Hoge, C.; Schierup, M.; Schumer, M.; Przeworski, M.
10.1101/2021.06.08.447603 — evolutionary biology — Posted on 2021-07-29
373 In vivo KRAS G12D/V Degradation Mediated by CANDDY Using a Modified Proteasome Inhibitor
Imanishi, S.; Huang, L.; Itakura, S.; Ishizaka, M.; Iwasaki, Y.; Yamaguchi, T.; Miyamoto-Sato, E.
10.1101/2021.04.23.441075 — molecular biology — Posted on 2021-07-29
375 Lytic transglycosylases mitigate periplasmic crowding by degrading soluble cell wall turnover products
Weaver, A. I.; Alvarez, L.; Rosch, K. M.; Ahmed, A.; Wang, G. S.; VanNieuwenzhe, M. S.; Cava, F.; Doerr, T.
10.1101/2021.07.27.453986 — microbiology — Posted on 2021-07-29
376 Functional and comparative genomics reveals conserved noncoding sequences in the nitrogen-fixing clade
Pereira, W. J.; Knaack, S. A.; Conde, D.; Chakraborty, S.; Folk, R. A.; Triozzi, P. M.; Balmant, K. M.; Dervinis, C.; Schmidt, H. W.; Ane, J.-M.; Roy, S.; Kirst, M.
10.1101/2021.07.27.453985 — plant biology — Posted on 2021-07-29
380 Protein Kinase C gamma Mutations Drive Spinocerebellar Ataxia Type 14 by Impairing Autoinhibition
Pilo, C. A.; Baffi, T. R.; Kornev, A. P.; Kunkel, M. T.; Malfavon, M.; Chen, D.-H.; Huang, L.-C.; Longman, C.; Kannan, N. A.; Raskind, W. H.; Gonzalez, D. J.; Taylor, S. S.; Gorrie, G.; Newton, A. C.
10.1101/2021.06.24.449810 — biochemistry — Posted on 2021-07-29
381 The whale shark genome reveals patterns of vertebrate gene family evolution
Tan, M.; Redmond, A.; Dooley, H.; Nozu, R.; Sato, K.; Kuraku, S.; Koren, S.; Phillippy, A.; Dove, A.; Read, T.
10.1101/685743 — genomics — Posted on 2021-07-28
382 SpotClean adjusts for spot swapping in spatial transcriptomics data
Ni, Z.; Prasad, A.; Chen, S.; Halberg, R. B.; Arkin, L.; Drolet, B.; Newton, M.; Kendziorski, C.
10.1101/2021.06.11.448105 — genomics — Posted on 2021-07-28
384 Natural selection and the advantage of recombination
Gerrish, P. J.; Galeota-Sprung, B.; Cordero, F.; Sniegowski, P. D.; Colato, A.; Hengartner, N. W.; Vejalla, V.; Chevalier, J.; Ycart, B.
10.1101/2020.08.28.271486 — evolutionary biology — Posted on 2021-07-28
385 Natural selection promotes the evolution of recombination 2: during the process of natural selection
Gerrish, P. J.; Cordero, F.; Galeota-Sprung, B.; Colato, A.; Vejalla, V.; Sniegowski, P. D.; Hengartner, N. W.
10.1101/2021.06.07.447324 — evolutionary biology — Posted on 2021-07-29
389 Cortical actin flow activates an alpha-catenin clutch to assemble adherens junctions
Noordstra, I.; Diez Hermoso, M.; Schimmel, L.; Bonfim-Melo, A.; Kalappurakkal, J. M.; Mayor, S.; Gordon, E.; Roca-Cusachs, P.; Yap, A. S.
10.1101/2021.07.28.454239 — cell biology — Posted on 2021-07-28
391 Comparing cortex-wide gene expression patterns between species in a common reference frame
englund, m.; James, S. S.; Bottom, R.; Huffman, K.; Wilson, S. P.; Krubitzer, L.
10.1101/2021.07.28.454203 — neuroscience — Posted on 2021-07-28
394 A Discriminative Characterization of Heschl's Gyrus Morphology using Spectral Graph Features
Maghsadhagh, S.; Dalboni da Rocha, J. L.; Benner, J.; Schneider, P.; Golestani, N.; Behjat, H.
10.1101/2021.05.04.442618 — neuroscience — Posted on 2021-07-28
396 An altered balance of integrated and segregated brain activity is a marker of cognitive deficits following sleep deprivation
Cross, N.; Pomares, F. B.; Nguyen, A.; Perrault, A. A.; Jegou, A.; Uji, M.; Lee, K.; Razavipour, F.; Ali, O. B. K.; Aydin, U.; Benali, H.; Grova, C.; Dang-Vu, T. T.
10.1101/2020.11.28.402305 — neuroscience — Posted on 2021-07-28
397 Cognitive, synaptic and neuropathological changesin Alzheimer's brain-inoculated mice
Lam, S.; Boluda, S.; Herard, A. S.; Petit, F.; Eddarkaoui, S.; Cambon, K.; Picq, J. L.; Buee, L.; Duyckaerts, C.; Haik, S.; Dhenain, M.
10.1101/2021.04.06.438654 — neuroscience — Posted on 2021-07-28
398 The universal language network: A cross-linguistic investigation spanning 45 languages and 11 language families.
Ayyash, D.; Malik-Moraleda, S.; Gallee, J.; Affourtit, J.; Hoffman, M.; Mineroff, Z.; Jouravlev, O.; Fedorenko, E.
10.1101/2021.07.28.454040 — neuroscience — Posted on 2021-07-29
399 An improved fluorescent noncanonical amino acid for measuring conformational distributions using time-resolved transition metal ion FRET
Zagotta, W. N.; Sim, B. S.; Nhim, A. K.; Raza, M. M.; Evans, E. G.; Venkatesh, Y.; Jones, C. M.; Mehl, R. A.; Petersson, J.; Gordon, S. E.
10.1101/2021.05.10.443484 — biophysics — Posted on 2021-07-28
400 DynaMorph: self-supervised learning of morphodynamic states of live cells
Wu, Z.; Chhun, B. B.; Popova, G.; Guo, S.-M.; Kim, C.; Yeh, L.-H.; Nowakowski, T. J.; Zou, J.; Mehta, S. B.
10.1101/2020.07.20.213074 — bioinformatics — Posted on 2021-07-28
401 Functional Inference of Gene Regulation using Single-Cell Multi-Omics
Kartha, V. K.; Duarte, F. M.; Hu, Y.; Ma, S.; Chew, J. G.; Lareau, C. A.; Earl, A.; Burkett, Z.; Kohlway, A. S.; Lebofski, R.; Buenrostro, J. D.
10.1101/2021.07.28.453784 — genomics — Posted on 2021-07-28
402 Genetic architecture of a mutation's expressivity
Schell, R.; Hale, J. J.; Mullis, M. N.; Matsui, T.; Foree, R.; Ehrenreich, I. M.
10.1101/2020.04.03.024547 — genetics — Posted on 2021-07-28
407 The Gut Microbiome of Exudivorous Wild and non-Wild Marmosets
Malukiewicz, J.; Cartwright, R. A.; Dergam, J. A.; Igayara, C. S.; Kessler, S.; Moreira, S. B.; Nash, L. T.; Nicola, P. A.; Pereira, L. C. M.; Pissinati, A.; Ruiz-Miranda, C. R.; Ozga, A. T.; Quirino, A. A.; Roos, C.; Silva, D. L.; Stone, A. C.; Grativol, A. D.
10.1101/708255 — microbiology — Posted on 2021-07-28
408 Mitochondria dysfunction in Charcot Marie Tooth 2B Peripheral Sensory Neuropathy
Gu, Y.; Guerra, F.; Hu, M.; Pope, A.; Sung, K.; Yang, W.; Jetha, S.; Shoff, T. A.; Gunatilake, T.; Dahlkamp, O.; Shi, L. Z.; Manganelli, F.; Nolano, M.; Zhou, Y.; Ding, J.; Bucci, C.; Wu, C.
10.1101/2021.07.28.454213 — neuroscience — Posted on 2021-07-28
409 The fasciola cinereum subregion of the hippocampus is important for the acquisition of visual contextual memory
Park, S.-B.; Lee, E.-Y.; Lim, H.-Y.; Yoo, S.-W.; Lee, E.; Jung, H.-S.; Sun, W.; Lee, I.
10.1101/748301 — neuroscience — Posted on 2021-07-28
413 Dopaminergic mechanisms underlying the expression of antipsychotic-induced dopamine supersensitivity in rats
Servonnet, A.; Allain, F.; Gravel-Chouinard, A.; Hernandez, G.; Bourdeau Caporuscio, C.; Legrix, M.; Levesque, D.; Rompre, P.-P.; Samaha, A.-N.
10.1101/2020.09.08.287664 — pharmacology and toxicology — Posted on 2021-07-28
414 An active RNA transport mechanism into plant vacuoles
Floyd, B. E.; Kazibwe, Z.; Morriss, S. C.; Mugume, Y.; Liu, A.-Y.; Ridout, V.; Luo, X.; MacIntosh, G. C.; Bassham, D. C.
10.1101/2021.07.28.454214 — plant biology — Posted on 2021-07-28
419 Environmental drivers of body size in North American bats
Alston, J. M.; Keinath, D. A.; Willis, C. K. R.; Lausen, C. L.; O'Keefe, J. M.; Tyburec, J.; Broders, H. G.; Moosman, P. R.; Carter, T. C.; Chambers, C. L.; Gillam, E. H.; Geluso, K.; Weller, T. J.; Burles, D.; Fletcher, Q. E.; Norquay, K. J.; Goheen, J. R.
10.1101/2021.07.28.454183 — ecology — Posted on 2021-07-28
420 Selective Requirement for Polycomb Repressor Complex 2 in the Generation of Specific Hypothalamic Neuronal Sub-types
Thor, S. S.; Salmani, B. Y.; Balderson, B.; Bauer, S.; Ekman, H.; Starkenberg, A.; Perlmann, T.; Piper, M.; Boden, M.
10.1101/2021.07.28.454060 — developmental biology — Posted on 2021-07-28
421 Annexin A1 is a polarity cue that directs planar mitotic spindle orientation during mammalian epithelial morphogenesis
Fankhaenel, M.; Golestan Hashemi, F. S.; Hosawi, M. M.; Mourao, L.; Skipp, P.; Morin, X.; Scheele, C. L.; Elias, S.
10.1101/2021.07.28.454117 — cell biology — Posted on 2021-07-28
422 Calcium/Calmodulin Dependent Protein Kinase Kinase 2 Regulates the Expansion of Tumor-induced Myeloid-Derived Suppressor Cells
Huang, W.; Liu, Y.; Luz, A.; Berrong, M.; Meyer, J.; Zou, Y.; Swann, E.; Sundaramoorthy, P.; Kang, Y.; Jauhari, S.; Lento, W.; Chao, N.; Racioppi, L.
10.1101/2021.07.28.454009 — immunology — Posted on 2021-07-28
423 Submandibular Injection of Indoleamine 2,3-Dioxygenase Galectin-3 Fusion Protein Inhibits and Prevents Periodontal Disease Progression Over 12 Weeks
Rocha, F.; Graves, C.; Altitinchi, A.; Farhadi, S. A.; Macias, S. L.; Wanchoo, A.; Hudalla, G. A.; Keselowsky, B. G.; Wallet, S. M.
10.1101/2021.07.28.454186 — immunology — Posted on 2021-07-28
424 The neuropeptide Pth2 modulates social behavior and anxiety in zebrafish
Anneser, L.; Gemmer, A.; Eilers, T.; Alcantara, I. C.; Loos, A.-Y.; Ryu, S.; Schuman, E.
10.1101/2021.07.28.454115 — neuroscience — Posted on 2021-07-28
427 Cell-specific Bioorthogonal Tagging of Glycoproteins in Co-culture
Cioce, A.; Calle, B.; Marchesi, A.; Bineva-Todd, G.; Flynn, H.; Li, Z.; Tastan, O. Y.; Roustan, C.; Keenan, T.; Both, P.; Huang, K.; Parmeggiani, F.; Snijders, A. P.; Kjaer, S.; Fascione, M. A.; Flitsch, S. L.; Schumann, B.
10.1101/2021.07.28.454135 — synthetic biology — Posted on 2021-07-28
429 Perception of structurally distinct effectors by the integrated WRKY domain of a plant immune receptor.
Mukhi, N.; Brown, H.; Gorenkin, D.; Ding, P.; Bentham, A. R.; Jones, J. D.; Banfield, M. J.
10.1101/2021.07.28.454147 — plant biology — Posted on 2021-07-28
430 CRISPR-Cas9 Screen Reveals PSMB3 Contributes to Gliomagenesis Through Proteasome-Dependent and Independent Mechanisms
Baisiwala, S.; Budhiraja, S.; Zolp, A.; Nandoliya, K.; Chen, L.; Park, C.; Perrault, E.; Saathoff, M.; Dmello, C.; Shireman, J.; Lin, P.; Dara, G.; McCortney, K.; Horbinski, C.; Sonabend, A.; Ahmed, A. U.
10.1101/2021.07.28.453566 — cancer biology — Posted on 2021-07-28
434 Development of lipidoid nanoparticles for siRNA delivery to neural cells
Khare, P.; Dave, K. M.; Kamte, Y. S.; Manoharan, M. A.; O'Donnell, L. A.; Manickam, D. S.
10.1101/2021.07.28.454207 — bioengineering — Posted on 2021-07-28
435 Catalytic cycling of human mitochondrial Lon protease
Mohammed, I.; Schmitz, K. A.; Schenck, N.; Topitsch, A.; Maier, T.; Abrahams, J. P.
10.1101/2021.07.28.454137 — biochemistry — Posted on 2021-07-28
437 The epithelial-specific ER stress sensor IRE1β enables host-microbiota crosstalk to affect colon goblet cell development
Grey, M. J.; De Luca, H.; Ward, D. V.; Kreulen, I. A. M.; Foley, S. E.; Thiagarajah, J. R.; McCormick, B. A.; Turner, J. R.; Lencer, W. I.
10.1101/2021.07.28.453864 — cell biology — Posted on 2021-07-28
438 The human nose organoid respiratory virus model: an ex-vivo human challenge model to study RSV and SARS-CoV-2 pathogenesis and evaluate therapeutics
Rajan, A.; Weaver, A. M.; Alosio, G. M.; Jelinski, J.; Johnson, H. L.; Venable, S. F.; McBride, T.; Aideyan, L.; Piedra, F.-A.; Ye, X.; Melicoff-Portillo, E.; Yerramilli, M. R. K.; Zeng, X.-L.; Mancini, M. A.; Stossi, F.; Maresso, A. W.; Kotkar, S. A.; Estes, M. K.; Blutt, S.; Avadhanula, V.; Piedra, P. A.
10.1101/2021.07.28.453844 — microbiology — Posted on 2021-07-28
439 A repurposed, non-canonical cytochrome c, chaperones calcium binding by PilY1 for type IVa pili formation
Herfurth, M.; Treuner-Lange, A.; Glatter, T.; Wittmaack, N.; Hoiczyk, E.; Pierik, A. J.; Sogaard-Andersen, L.
10.1101/2021.07.28.454143 — microbiology — Posted on 2021-07-28
441 Metallothionein 3-zinc axis suppresses caspase-11 inflammasome activation and impairs antibacterial immunity
Chowdhury, D.; Gardner, J.; Satpati, A.; Nookala, S.; Mukundan, S.; Porollo, A.; Landero Figueroa, J.; Subramanian, K.
10.1101/2021.07.28.454033 — immunology — Posted on 2021-07-28
442 PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade
Srour, N.; Villareal, O. D.; Yu, Z.; Preston, S.; Miller, W. H.; Szewczyk, M.; Barsyte-Lovejoy, D.; Xu, H.; del Rincon, S. V.; Richard, S.
10.1101/2021.07.28.454202 — immunology — Posted on 2021-07-28
444 Unveiling Mutation Effects on the Structural Dynamics of the Main Protease from SARS-CoV-2 with Hybrid Simulation Methods
Philot, E. A.; Gasparini, P.; de Mattos, J. C.; Magro, A.; Torres-Bonfim, E.; Quiroz, R. C. N.; Klioussof, A.; Perahia, D.; Scott, A. L. B.
10.1101/2021.07.17.452787 — biophysics — Posted on 2021-07-28
450 SARS-CoV-2 Lambda variant exhibits higher infectivity and immune resistance
Kimura, I.; Kosugi, Y.; Wu, J.; Yamasoba, D.; Butlertanaka, E. P.; Tanaka, Y. L.; Liu, Y.; Shirakawa, K.; Kazuma, Y.; Nomura, R.; Horisawa, Y.; Tokunaga, K.; Takaori-Kondo, A.; Arase, H.; The Genotype to Phenotype Japan (G2P-Japan) Consortium, ; Saito, A.; Nakagawa, S.; Sato, K.
10.1101/2021.07.28.454085 — microbiology — Posted on 2021-07-28
452 SARS-CoV-2 in the Republic of Guinea: Fragment and Whole-Genome Sequencing, Phylogenetic Analysis
Kritsky, A. A.; Krasnov, Y. M.; Keita, M.; Keita, S.; Fedorov, A. V.; Shevtsova, A. P.; Guseva, N. P.; Kazorina, E. V.; Sosedova, E. A.; Katyshev, A. D.; Naryshkina, E. A.; Kolomoets, E. V.; Shcherbakova, S. A.; Popova, A. Y.; Kutyrev, V. V.
10.1101/2021.07.28.454098 — microbiology — Posted on 2021-07-28
453 Single-Cell Profiling of the Antigen-Specific Response to BNT162b2 SARS-CoV-2 RNA Vaccine
Kramer, K. J.; Wilfong, E. M.; Voss, K.; Barone, S.; Shiakolas, A. R.; Raju, N.; Roe, C. E.; Suryadevara, N.; Walker, L. M.; Wall, S. C.; Paulo, A.; Schaefer, S.; Dahunsi, D.; Westlake, C. S.; Crowe, J. E.; Carnahan, R. H.; Rathmell, J. C.; Bonami, R. H.; Georgiev, I. S.; Irish, J. M.
10.1101/2021.07.28.453981 — immunology — Posted on 2021-07-28
459 Structural insights into tick-borne encephalitis virus neutralization and animal protection by a therapeutic antibody
Baykov, I. K.; Chojnowski, G.; Pachl, P.; Matveev, A. L.; Moor, N. A.; Emelianova, L. A.; Rezacova, P. M.; Lamzin, V. S.; Tikunova, N. V.
10.1101/2021.07.28.453943 — biochemistry — Posted on 2021-07-28
460 Large-scale genome-wide association study of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traits.
May-Wilson, S.; Matoba, N.; Wade, K. H.; Hottenga, J.-J.; Concas, M. P.; Mangino, M.; Grzeszkowiak, E. J.; Menni, C.; Gasparini, P.; Timpson, N. J.; Veldhuizen, M. G.; de Geus, E. J.; Wilson, J. F.; Pirastu, N.
10.1101/2021.07.28.454120 — genetics — Posted on 2021-07-28
461 Filopodia powered by class X myosin promote fusion of mammalian myoblasts
Hammers, D. W.; Hart, C. C.; Matheny, M. K.; Heimsath, E. G.; Lee, Y. i.; Hammer, J. A.; Cheney, R. E.; Sweeney, L.
10.1101/2021.07.28.454163 — cell biology — Posted on 2021-07-28
462 Host cell maturation modulates parasite invasion and sexual differentiation in Plasmodium.
Hentzschel, F.; Gibbins, M. P.; Attipa, C.; Beraldi, D.; Moxon, C.; Otto, T. D.; Marti, M.
10.1101/2021.07.28.453984 — microbiology — Posted on 2021-07-28
463 T helper cell-licensed mast cells promote inflammatory Th17 cells
Leveque, E.; Joulia, R.; Petitfils, C.; Mas-Orea, X.; Payros, G.; Laurent, C.; Gaudenzio, N.; Dietrich, G.; Valitutti, S.; Cenac, N.; Espinosa, E.
10.1101/2021.07.28.454103 — immunology — Posted on 2021-07-28
467 Integrative analysis of the salt stress response in cyanobacteria
Klaehn, S.; Mikkat, S.; Riediger, M.; Georg, J.; Hess, W. R.; Hagemann, M.
10.1101/2021.07.28.454097 — systems biology — Posted on 2021-07-28
472 Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides
Payne, C. D.; Vadlamani, G.; Hajiaghaalipour, F.; Muhammad, T.; Fisher, M. F.; Andersson, H. S.; Göransson, U.; Clark, R. J.; Bond, C. S.; Mylne, J. S.; Rosengren, K. J.
10.1101/2021.07.28.454061 — biochemistry — Posted on 2021-07-28
473 A non-functional copy of the salmonid sex determining gene (sdY) is responsible for the "apparent" XY females in Chinook salmon, Oncorhynchus tshawytscha.
Bertho, S.; Herpin, A.; Jouanno, E.; Yano, A.; Bobe, J.; Parrinello, H.; Journot, L.; Guyomard, R.; Thomas, M.; Swanson, P.; McKinney, G. J.; Kevin, W.; Mariah, M.; Schartl, M.; Guiguen, Y.
10.1101/2021.07.28.454148 — genetics — Posted on 2021-07-28
475 Inhibition of Mul1-mediated ubiquitination promotes mitochondria-associated translation
Gao, Y.; Cardamone, M. D.; Kwan, J.; Hekman, R.; Orofino, J.; Lyons, S. M.; Emili, A.; Perissi, V.
10.1101/2021.07.28.454107 — cell biology — Posted on 2021-07-28
477 Automated slice-specific z-shimming for fMRI of the human spinal cord
Kaptan, M.; Vannesjo, S. J.; Mildner, T.; Horn, U.; Hartley-Davies, R.; Oliva, V.; Brooks, J. C. W.; Weiskopf, N.; Finsterbusch, J.; Eippert, F.
10.1101/2021.07.27.454049 — neuroscience — Posted on 2021-07-28
478 Data and model considerations for estimating time-varying functional connectivity in fMRI
Ahrends, C.; Stevner, A.; Pervaiz, U.; Kringelbach, M. L.; Vuust, P.; Woolrich, M.; Vidaurre, D.
10.1101/2021.07.28.454017 — neuroscience — Posted on 2021-07-28
479 Symmetry and simplicity spontaneously emerge from the algorithmic nature of evolution
Johnston, I.; Dingle, K.; Greenbury, S. F.; Camargo, C. Q.; Doye, J. P. K.; Ahnert, S. E.; louis, a.
10.1101/2021.07.28.454038 — evolutionary biology — Posted on 2021-07-28
485 Structural and functional network-level reorganization in the coding of auditory motion directions and sound source locations in the absence of vision
Battal, C.; Gurtubay-Antolin, A.; Rezk, M.; Mattioni, S.; Bertonati, G.; Occelli, V.; Bottini, R.; Targher, S.; Maffei, C.; Jovicich, J.; Collignon, O.
10.1101/2021.07.28.454106 — neuroscience — Posted on 2021-07-28
488 Phosphate starvation response precedes drought response in field-grown plants
Nagatoshi, Y.; Ikazaki, K.; Mizuno, N.; Kobayashi, Y.; Fujii, K.; Ogiso-Tanaka, E.; Ishimoto, M.; Yasui, Y.; Oya, T.; Fujita, Y.
10.1101/2021.07.28.453724 — plant biology — Posted on 2021-07-28
489 B Cell Receptor Signaling Drives APOBEC3 Expression Via Direct Enhancer Regulation in Chronic Lymphocytic Leukemia B Cells
Wang, Z.; Yan, H.; Boysen, J. C.; Secreto, C. R.; Zhong, J.; Zhou, J.; Gan, H.; Yu, C.; Braggio, E.; Slager, S. L.; Parikh, S. A.; Kay, N. E.
10.1101/2021.07.27.454050 — cancer biology — Posted on 2021-07-28
492 Heritable changes in division speed accompany the diversification of single T cell fate
Plambeck, M.; Kazeroonian, A.; Loeffler, D.; Schroeder, T.; Busch, D. H.; Flossdorf, M.; Buchholz, V. R.
10.1101/2021.07.28.454102 — immunology — Posted on 2021-07-28
494 Utilization efficiency of human milk oligosaccharides by human-associated Akkermansia is strain-dependent
Luna, E.; Parkar, S. G.; Kirmiz, N.; Hartel, S.; Hearn, E.; Hossine, M.; Kurdian, A.; Mendoza, C.; Orr, K.; Padilla, L.; Ramirez, K.; Salcedo, P.; Serrano, E.; Choudhury, B.; Paulchakrabarti, M.; Parker, C. T.; Huynh, S.; Cooper, K.; Flores, G. E.
10.1101/2021.07.26.453919 — microbiology — Posted on 2021-07-28
496 Maturation, developmental site, and pathology dictate murine neutrophil function
Mackey, J. B. G.; McFarlane, A. J.; Jamieson, T.; Jackstadt, R.; Raffo-Iraolagoitia, X. L.; Secklehner, J.; Cortes-Lavaud, X.; Fercoq, F.; Clarke, W.; Hedley, A.; Gilroy, K.; Lilla, S.; Vuononvirta, J.; Graham, G. J.; De Filippo, K.; Murphy, D. J.; Steele, C. W.; Norman, J. C.; Bird, T. G.; Mann, D. A.; Morton, J. P.; Zanivan, S.; Sansom, O. J.; Carlin, L. M.
10.1101/2021.07.21.453108 — immunology — Posted on 2021-07-28
503 ESCRT-I controls lysosomal membrane protein homeostasis and restricts MCOLN1-dependent TFEB/TFE3 signaling.
Wrobel, M.; Szymanska, E.; Budick-Harmelin, N.; Kolmus, K.; Goryca, K.; Dabrowska, M.; Paziewska, A.; Mikula, M.; Cendrowski, J.; Miaczynska, M.
10.1101/2021.07.26.453823 — cell biology — Posted on 2021-07-28
506 MAFB surrogates the glucocorticoid receptor ability to induce tolerogenesis in dendritic cells
Morante-Palacios, O.; Ciudad, L.; Micheroli, R.; de la Calle-Fabregat, C.; Li, T.; Barbisan, G.; Houtman, M.; Edalat, S.; Frank-Bertoncelj, M.; Ospelt, C.; Ballestar, E.
10.1101/2021.07.27.453975 — immunology — Posted on 2021-07-28
507 Endorsement and Phylogenetic Analysis of some Fabaceae Plants based on DNA Barcoding gene MatK
Abdelsalam, N. R.; Hasan, M. E.; Rabie, S. M. A.; El-wakeel, H. E.-D. M. F.; Zaitoun, A. F.; Ghareeb, R. Y.; Abdelsalam, A. Z.; Aly, H. M.; Ibrahim, A. A.; Hemeida, A. A.
10.1101/2021.07.27.454001 — bioinformatics — Posted on 2021-07-28
511 Effects of a blend of chestnut and quebracho tannins on gut health and performance of broiler chickens
Redondo, E. A.; Redondo, L. M.; Bruzzone, O. A.; Diaz-Carrasco, J. M.; Cabral, C.; Garces, V. M.; Lineiro, M. M.; Fernandez Miyakawa, M. E.
10.1101/2021.07.27.454004 — microbiology — Posted on 2021-07-27
513 BFG-PCA: tools and resources that expand the potential for binary protein interaction discovery
Evans-Yamamoto, D.; Rouleau, F. D.; Nanda, P.; Makanae, K.; Liu, Y.; Despres, P. C.; Matsuo, H.; Seki, M.; Dube, A. K.; Ascencio, D.; Yachie, N.; Landry, C. R.
10.1101/2021.07.27.453987 — systems biology — Posted on 2021-07-27
514 Executable Network of SARS-CoV-2-Host Interaction Predicts Drug Combination Treatments
Howell, R.; Clarke, M. A.; Reuschl, A.-K.; Chen, T.; Abott-Imboden, S.; Singer, M.; Lowe, D. M.; Bennett, C. L.; Chain, B.; Jolly, C.; Fisher, J.
10.1101/2021.07.27.453973 — systems biology — Posted on 2021-07-27
516 The genetic interaction of REVOLUTA and WRKY53 links plant development, senescence, and immune responses
Bresson, J.; Doll, J.; Vasseur, F.; Stahl, M.; von Roepenack-Lahaye, E.; Kilian, J.; Stadelhofer, B.; Kremer, J. M.; Kolb, D.; Wenkel, S.; Zentgraf, U.
10.1101/2021.07.27.454007 — plant biology — Posted on 2021-07-27
517 Average stride length and stride rate of Thoroughbreds and Quarter Horses during 'Sprint and 'Classic races
Vergara-Hernandez, F. B.; Nielsen, B. D.; Robison, C. I.; Fabus, T. A.; Kompare, J. L.; LeCompte Lazic, R. A.; Colbath, A. C.
10.1101/2021.07.27.453998 — physiology — Posted on 2021-07-27
520 Complete Mitochondrial and Plastid DNA Sequences of the Freshwater Green Microalga Medakamo hakoo
Takusagawa, M.; Kato, S.; Matsunaga, S.; Maruyama, S.; Tsujimoto-Inui, Y.; Nozaki, H.; Yagisawa, F.; Ohnuma, M.; Kuroiwa, H.; Kuroiwa, T.; Misumi, O.
10.1101/2021.07.27.453968 — genomics — Posted on 2021-07-27
521 Can fMRI functional connectivity index dynamic neural communication?
Alonso Martinez, S.; Llera Arenas, A.; Ter Horst, G. T.; Vidaurre, D.
10.1101/2021.07.27.453965 — neuroscience — Posted on 2021-07-27
522 Orthogonal but linked neural codes for value
Maisson, D. J.; Fine, J. M.; Yoo, S. B. M.; Cash-Padgett, T. D.; Wang, M. Z.; Sleezer, B. J.; Zimmermann, J.; Hayden, B. Y.
10.1101/2021.07.27.453966 — neuroscience — Posted on 2021-07-27
526 Molecular Pathophysiology of Cardiac Injury and Cardiac Microthrombi in Fatal COVID-19: Insights from Clinico-histopathologic and Single Nuclei RNA Sequencing Analyses
Fukuma, N.; Hulke, M. L.; Brener, M. I.; Golob, S.; Zilinyi, R.; Zhou, Z.; Tzimas, C.; Russo, I.; McGroder, C.; Pfeiffer, R.; Chong, A.; Zhang, G.; Burkhoff, D.; Leon, M. B.; Maurer, M.; Moses, J. W.; Uhlemann, A.-C.; Hibshoosh, H.; Uriel, N.; Szabolcs, M. J.; Redfors, B.; Marboe, C. C.; Baldwin, M. R.; Tucker, N. R.; Tsai, E. J.
10.1101/2021.07.27.453843 — pathology — Posted on 2021-07-27
527 Met-HER3 crosstalk supports proliferation via MPZL3 in MET-amplified cancer cells
Stern, Y. E.; Duhamel, S.; Al-Ghabkari, A.; Monast, A.; Fiset, B.; Aboulizadeh, F.; Yao, Z.; Stagljar, I.; Walsh, L. A.; Park, M.
10.1101/2021.07.27.454013 — cancer biology — Posted on 2021-07-27
528 Resurrecting Golgi proteins to grasp Golgi ribbon formation and self-association under stress
mendes, l. f. s.; Batista, M. R. B.; Kava, E.; Bleicher, L.; Micheletto, M. C.; Costa-Filho, A. J.
10.1101/2021.07.27.453980 — biophysics — Posted on 2021-07-27
529 Accelerated epigenetic aging and inflammatory/immunological profile (ipAGE) in patients with chronic kidney disease
Yusipov, I.; Kondakova, E.; Kalyakulina, A.; Krivonosov, M.; Lobanova, N.; Bacalini, M. G.; Franceschi, C.; Vedunova, M.; Ivanchenko, M.
10.1101/2021.07.23.453588 — bioinformatics — Posted on 2021-07-27
530 Quantification and visualization of the tumor microenvironment heterogeneity from spatial transcriptomic experiments
Ospina, O. E.; Wilson, C. M.; Soupir, A. C.; Berglund, A.; Smalley, I.; Tsai, K. Y.; Fridley, B. L.
10.1101/2021.07.27.454023 — bioinformatics — Posted on 2021-07-27
532 Deep learning-based segmentation of high-resolution computed tomography image data outperforms commonly used automatic bone segmentation methods
Patton, D. M.; Henning, E. N.; Goulet, R. W.; Carroll, S. K.; Bigelow, E. M. R.; Provencher, B.; Piche, N.; Marsh, M.; Jepsen, K. J.; Bredbenner, T. L.
10.1101/2021.07.27.453890 — bioengineering — Posted on 2021-07-27
533 Targeted Protein Acetylation in Cells Using Heterobifunctional Molecules
Wang, W. W.; Chen, L.-Y.; Wozniak, J.; Jadhav, A. M.; Anderson, H.; Malone, T.; Parker, C. G.
10.1101/2021.07.27.454011 — biochemistry — Posted on 2021-07-27
534 Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism
Ryan, D. G.; Yang, M.; Prag, H. A.; Blanco, G. R.; Nikitopoulou, E.; Segarra-Mondejar, M.; Powell, C. A.; Young, T.; Burger, N.; Miljkovic, J. L.; Minczuk, M.; Murphy, M. P.; Von Kriegsheim, A.; Frezza, C.
10.1101/2021.07.27.453996 — biochemistry — Posted on 2021-07-27
536 Host-symbiont stress response to lack-of-sulfide in the giant ciliate mutualism
Espada-Hinojosa, S.; Drexel, J.; Kesting, J.; Kniha, E.; Pifeas, I.; Schuster, L.; Volland, J.-M.; Zambalos, H. C.; Bright, M.
10.1101/2021.07.27.454000 — ecology — Posted on 2021-07-27
537 ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals.
Pashkova, N.; Gakhar, L.; Winistorfer, S.; Minard, A. Y.; Schnicker, N. J.; Yu, L.; Johnson, I. E.; Piper, R. C.
10.1101/2021.07.27.454047 — cell biology — Posted on 2021-07-27
540 Sex differences in age- and episodic memory-related effects on task-based functional connectivity
Subramaniapillai, S.; Rajagopal, S.; Ankudowich, E.; Pasvanis, S.; Misic, B.; Rajah, N.
10.1101/2021.07.27.453878 — neuroscience — Posted on 2021-07-27
542 Non-invasive imaging of gene expression and protein secretion dynamics in living mice
Nourse, J.; Tokalov, S.; Khokhar, S.; Khan, E.; Schott, L. K.; Hinz, L.; Eder, L.; Arnold-Schild, D.; Probst, H. C.; Danckwardt, S.
10.1101/2021.07.08.451623 — pharmacology and toxicology — Posted on 2021-07-27
544 Deposition chamber technology as building blocks for a standardized brain-on-chip framework
Maisonneuve, B. G. C.; Libralesso, L.; Miny, L.; Batut, A.; Rontard, J.; Gleyzes, M.; Boudra, B.; Vieira, J.; Debis, D.; Larramendy, F.; Jost, V.; Honegger, T.
10.1101/2021.06.21.449231 — bioengineering — Posted on 2021-07-27
545 Structural basis of PETISCO complex assembly during piRNA biogenesis in C. elegans
Perez-Borrajero, C.; Podvalnaya, N.; Holleis, K.; Raffael, L.; Karaulanov, E.; Simon, B.; Basquin, J.; Hennig, J.; Ketting, R. F.; Falk, S.
10.1101/2021.05.20.444926 — biochemistry — Posted on 2021-07-27
549 Paracrine regulation of neural crest EMT by placodal MMP28
GOUIGNARD, N.; BIBONNE, A.; Mata, J. F.; Bajanca, F.; Berki, B.; Barriga, E. H.; SAINT-JEANNET, J.-P.; THEVENEAU, E.
10.1101/2020.11.19.389544 — developmental biology — Posted on 2021-07-27
551 A Tad-like apparatus is required for contact-dependent prey killing in predatory social bacteria
Seef, S.; Herrou, J.; de Boissier, P.; My, L.; Brasseur, G.; Robert, D.; Jain, R.; Mercier, R.; Cascales, E.; Habermann, B. H.; Mignot, T.
10.1101/2021.02.25.432843 — microbiology — Posted on 2021-07-27
552 Chemoreceptor Co-Expression in Drosophila Olfactory Neurons
Task, D.; Lin, C.-C.; Vulpe, A.; Afify, A.; Ballou, S.; Brbic, M.; Schlegel, P.; Jefferis, G. S. X. E.; Li, H.; Menuz, K.; Potter, C. J.
10.1101/2020.11.07.355651 — neuroscience — Posted on 2021-07-27
555 Cancer phylogenetics using single-cell RNA-seq data
Moravec, J. C.; Lanfear, R.; Spector, D.; Diermeier, S.; Gavryushkin, A.
10.1101/2021.01.07.425804 — cancer biology — Posted on 2021-07-27
557 DeepLIIF: Deep Learning-Inferred Multiplex ImmunoFluorescence for IHC Image Quantification
Ghahremani, P.; Li, Y.; Kaufman, A.; Vanguri, R.; Greenwald, N.; Angelo, M.; Hollmann, T. J.; Nadeem, S.
10.1101/2021.05.01.442219 — bioinformatics — Posted on 2021-07-27
558 Miniaturizing wet scrubbers for aerosolized droplet capture
Lee, U. N.; van Neel, T. L.; Lim, F. Y.; Khor, J. W.; He, J.; Vaddi, R. S.; Ong, A. Q.; Tang, A.; Berthier, J.; Meschke, J. S.; Novosselov, I. V.; Theberge, A. B.; Berthier, E.
10.1101/2021.03.23.436614 — bioengineering — Posted on 2021-07-27
563 Lytic transglycosylases mitigate periplasmic crowding by degrading soluble cell wall turnover products
Weaver, A. I.; Alvarez, L.; Rosch, K. M.; Ahmed, A.; Wang, G. S.; VanNieuwenzhe, M. S.; Cava, F.; Doerr, T.
10.1101/2021.07.27.453986 — microbiology — Posted on 2021-07-27
566 A locus conferring tolerance to Theileria infection in African cattle
Wragg, D.; Cook, E. A. J.; Latre de Late, P.; Sitt, T.; Hemmink, J. D.; Makau, J.; Njeru, R.; Powell, J.; Paxton, E.; Callaby, R.; Talenti, A.; Miyunga, A. A.; Ndambuki, G.; Mwaura, S.; Auty, H.; Matika, O.; Hassan, M. A.; Marshall, K.; Connelley, T. K.; Morrison, L.; Bronsvoort, B. M.; Morrison, W. I.; Toye, P.; Prendergast, J. G.
10.1101/2021.07.26.453771 — genetics — Posted on 2021-07-27
574 Optogenetic actuator/biosensor circuits for large-scale interrogation of ERK dynamics identify sources of MAPK signaling robustness.
Dessauges, C.; Mikelson, J.; Dobrzynski, M.; Jacques, M.-A.; Frismantiene, A.; Gagliardi, P. A.; Khammash, M.; Pertz, O.
10.1101/2021.07.27.453955 — systems biology — Posted on 2021-07-27
575 Functional and comparative genomics reveals conserved noncoding sequences in the nitrogen-fixing clade
Pereira, W. J.; Knaack, S. A.; Conde, D.; Chakraborty, S.; Folk, R. A.; Triozzi, P. M.; Balmant, K. M.; Dervinis, C.; Schmidt, H. W.; Ane, J.-M.; Roy, S.; Kirst, M.
10.1101/2021.07.27.453985 — plant biology — Posted on 2021-07-27
576 Ribosomal protein L23 drives the metastasis of hepatocellular carcinoma via upregulating MMP9
Chen, J.; Li, F.; Yang, M.; Zhou, Y.; Deng, H.; Zhou, H.; Cheng, S.; Zhang, D.; He, X.; Mai, L.; Chen, Y.
10.1101/2021.07.27.453993 — cancer biology — Posted on 2021-07-27
577 Analysis of long and short enhancers in melanoma cell states
Mauduit, D.; Minnoye, L.; Taskiran, I. I.; De Waegeneer, M.; Christiaens, V.; Hulselmans, G.; Demeulemeester, J.; Wouters, J.; Aerts, S.
10.1101/2021.07.27.453936 — genomics — Posted on 2021-07-27
579 A novel anti-influenza combined therapy assessed by single cell RNA-sequencing
Medaglia, C.; Kolpakov, I.; Zhu, Y.; Constant, S.; Huang, S.; Zwygart, A. C.-A.; Cagno, V.; Dermitzakis, E.; Stellacci, F.; Xenarios, I.; Tapparel, C.
10.1101/2021.07.27.453967 — genomics — Posted on 2021-07-27
580 Development of an ASO therapy for Angelman syndrome by targeting an evolutionarily conserved region at the start of the UBE3A-AS transcript
Dindot, S. V.; Christian, S.; Murphy, W. J.; Berent, A.; Panagoulias, J.; Schlafer, A.; Ballard, J.; Radeva, K.; Robinson, R.; Myers, L.; Jepp, T.; Shaheen, H.; Hillman, P.; Konganti, K.; Hillhouse, A.; Bredemeyer, K. R.; Black, L.; Douville, J.; the FIRE consortium,
10.1101/2021.07.27.453820 — genetics — Posted on 2021-07-27
585 Mutated in Colorectal Cancer (MCC): a centrosomal protein that relocalizes to the ncMTOC during intestinal cell differentiation
Tomaz, L. B.; Liu, B. A.; Ong, S. L. M.; Tan, E. K.; M, M.; Tolwinski, N. S.; Williams, C. S.; Gingras, A.-C.; Leushacke, M.; Dunn, N. R.
10.1101/2021.07.27.453941 — cell biology — Posted on 2021-07-27
586 To bin or not to bin: analyzing single-cell growth data
Kar, P.; Tiruvadi-Krishnan, S.; Männik, J.; Männik, J.; Amir, A.
10.1101/2021.07.27.453901 — microbiology — Posted on 2021-07-27
588 CD8+ T Cell Metabolic Rewiring Defined by Single-Cell RNA-Sequencing Identifies a Critical Role of ASNS Expression Dynamics in T Cell Differentiation
Fernandez-Garcia, J.; Franco, F.; Parik, S.; Pane, A. A.; Broekaert, D.; Van Elsen, J.; Vermeire, I.; Van Brussel, T.; Schepers, R.; Modave, E.; Karakach, T.; Carmeliet, P.; Lambrechts, D.; Ho, P.-C.; Fendt, S.-M.
10.1101/2021.07.27.453976 — immunology — Posted on 2021-07-27
589 Nitrate-regulated growth processes involve activation of gibberellin pathway
Camut, L.; Gallova, B.; Jilli, L.; Sirlin-Josserand, M.; Carrera, E.; Sakvarelidze-Achard, L.; Zumsteg, J.; Heintz, D.; Ruffel, S.; Krouk, G.; Thomas, S. G.; Hedden, P.; Phillips, A. L.; Daviere, J.-M.; Achard, P.
10.1101/2021.07.27.453969 — plant biology — Posted on 2021-07-27
590 3D Convolutional Neural Networks for Classification of Alzheimer's and Parkinson's Disease with T1-Weighted Brain MRI
Dhinagar, N. J.; Thomopoulos, S. I.; Owens-Walton, C.; Stripelis, D.; Ambite, J.-L.; Ver Steeg, G.; Weintraub, D.; Cook, P.; McMillan, C.; Thompson, P. M.
10.1101/2021.07.26.453903 — bioinformatics — Posted on 2021-07-27
593 Disordered climate threatens short-distance migrants
YANG, H.; Yu, L.; Qi, H.; Fu, S.; Wang, Y.; Yang, J.; Du, H.
10.1101/2021.07.27.453912 — ecology — Posted on 2021-07-27
596 Uncoupling of the Diurnal Growth Program by Artificial Genome Relaxation in Synechocystis sp. PCC 6803
Behle, A.; Dietsch, M.; Goldschmidt, L.; Murugathas, W.; Brandt, D.; Busche, T.; Kalinowski, J.; Ebenhoeh, O.; Axmann, I. M.; Machne, R.
10.1101/2021.07.26.453758 — microbiology — Posted on 2021-07-27
598 Spores and extracellular matrix components impart molecular order in Bacillus subtilis biofilms.
Azulay, D. N.; Spaeker, O.; Ghrayeb, M.; Wilsch-Brauninger, M.; Scoppola, E.; Burghammer, M.; Zizak, I.; Bertinetti, L.; Politi, Y.; Chai, L.
10.1101/2021.07.27.453653 — microbiology — Posted on 2021-07-27
599 Quantification of within patient Staphylococcus aureus phenotypic heterogeneity as a proxy for presence of persisters across clinical presentations
Baer, J.; Boumasmoud, M.; Mairpady Shambat, S.; Vulin, C.; Huemer, M.; Schweizer, T. A.; Gómez Mejia, A.; Eberhard, N.; Achermann, Y.; Zingg, P. O.; Mestres, C. A.; Brugger, S. D.; Schüpbach, R. A.; Kouyos, R. D.; Hasse, B.; Zinkernagel, A. S.
10.1101/2021.07.27.453929 — microbiology — Posted on 2021-07-27
600 The olfactory gating of visual preferences to human skin and colors in mosquitoes
Alonso San Alberto, D.; Rusch, C.; Zhan, Y.; Straw, A. D.; Montell, C.; Riffell, J. A.
10.1101/2021.07.26.453916 — neuroscience — Posted on 2021-07-27
607 Deep Learning Image Classification of Red Blood Cell Deformability
Lamoureux, E. S.; Islamzada, E.; Wiens, M. V. J.; Matthews, K.; Duffy, S. P.; Ma, H.
10.1101/2021.07.26.453886 — bioengineering — Posted on 2021-07-27
610 CASowary: CRISPR-Cas13 guide RNA predictor for transcript depletion
Krohannon, A.; Srivastava, M.; Rauch, S.; Srivastava, R.; Dickinson, B.; Janga, S. C.
10.1101/2021.07.26.453663 — bioinformatics — Posted on 2021-07-27
611 Transcriptomic Analysis of Human Skin Wound Healing and Rejuvenation Following Ablative Fractional Laser Treatment
Sherrill, J. D.; Finlay, D.; Binder, R. L.; Robinson, M. K.; Wei, X.; Tiesman, J. P.; Flagler, M. J.; Loftus, J. M.; Kimball, A. B.; Bascom, C. C.; Isfort, R. J.
10.1101/2021.07.26.453869 — bioinformatics — Posted on 2021-07-27
612 Self-supervised contrastive learning for integrative single cell RNA-seq data analysis
Han, W.; Cheng, Y.; Chen, J.; Zhong, H.; Hu, Z.; Chen, S.; Zong, L.; King, I.; Gao, X.; Li, Y.
10.1101/2021.07.26.453730 — bioinformatics — Posted on 2021-07-27
614 Engineering Viral Vectors for Acoustically Targeted Gene Delivery
Li, H.; Heath, J. E.; Trippett, J. S.; Shapiro, M. G.; Szablowski, J. O.
10.1101/2021.07.26.453904 — bioengineering — Posted on 2021-07-27
616 Spatio-temporal dynamics of intra-host variability in SARS-CoV-2 genomes
Pathak, A. K.; Mishra, G. P.; Uppili, B.; Walia, S.; Fatihi, S.; Abbas, T.; Banu, S.; Ghosh, A.; Kanampalliwar, A.; Jha, A.; Fatima, S.; Aggarwal, S.; Dhar, M. S.; Marwal, R.; V. S., R.; Ponnusamy, K.; Kabra, S.; Rakshit, P.; Bhoyar, R. C.; Jain, A.; Divakar, M. K.; Imran, M.; Faruq, M.; Sowpati, D. T.; Thukral, L.; Raghav, S. K.; Mukerji, M.
10.1101/2020.12.09.417519 — genomics — Posted on 2021-07-27
620 Ultrastructural and functional analysis of extra-axonemal structures in trichomonads
Coceres, V. M.; Iriarte, L. S.; Miranda-Magalhaes, A.; de Andrade, T. A. S.; de Miguel, N.; Pereira-Neves, A.
10.1101/2021.07.26.453887 — cell biology — Posted on 2021-07-27
622 AJILE12: Long-term naturalistic human intracranial neural recordings and pose
Peterson, S. M.; Singh, S. H.; Dichter, B.; Scheid, M.; Rao, R. P. N.; Brunton, B. W.
10.1101/2021.07.26.453884 — neuroscience — Posted on 2021-07-27
624 Mechanism of a COVID-19 nanoparticle vaccine candidate that elicits a broadly neutralizing antibody response to SARS-CoV-2 variants
Zhang, Y.-N.; Paynter, J.; Sou, C.; Fourfouris, T.; Wang, Y.; Abraham, C.; Ngo, T.; Zhang, Y.; He, L.; Zhu, J.
10.1101/2021.03.26.437274 — immunology — Posted on 2021-07-27
626 Contribution of 3D genome topological domains to genetic risk of cancers
Jablonski, K. P.; Carron, L.; Mozziconacci, J.; Forne, T.; Hütt, M.-T.; Lesne, A.
10.1101/2021.07.26.453813 — genetics — Posted on 2021-07-27
628 Airborne environmental DNA metabarcoding for the monitoring of terrestrial insects - a proof of concept
Roger, F.; Ghanavi, H.; Danielsson, N. N.; Wahlberg, N.; Löndahl, J.; Pettersson, L. B.; Andersson, G. K. S.; Boke-Olen, N.; Clough, Y.
10.1101/2021.07.26.453860 — ecology — Posted on 2021-07-27
629 A SUMO-dependent regulatory switch connects the piRNA pathway to the heterochromatin machinery in Drosophila
Andreev, V. I.; Yu, C.; Wang, J.; Schnabl, J.; Tirian, L.; Gehre, M.; Handler, D.; Duchek, P.; Novatchkova, M.; Baumgartner, L.; Meixner, K.; Sienski, G.; Patel, D. J.; Brennecke, J.
10.1101/2021.07.27.453956 — molecular biology — Posted on 2021-07-27
632 A novel mobile RND-type efflux pump gene cluster, tmexC3D2-toprJ3, confers tigecycline resistance in Pseudomonas alcaligenes
Maehana, S.; Eda, R.; Niida, N.; Hirabayashi, A.; Sakai, K.; Furukawa, T.; Sei, K.; Kitasato, H.; Suzuki, M.
10.1101/2021.07.26.453812 — microbiology — Posted on 2021-07-27
635 Cell-specific expression buffering promotes cell survival and cancer robustness
Lin, H.-K.; Cheng, J.-H.; Wu, C.-C.; Hsieh, F.-S.; Dunlap, C. A.; Chen, S.-h.
10.1101/2021.07.26.453775 — systems biology — Posted on 2021-07-27
636 Individual repeatability, species differences, and the influence of socio-ecological factors on neophobia in 10 corvid species
Miller, R.; Lambert, M. L.; Frohnwieser, A.; Brecht, K. F.; Bugnyar, T.; Crampton, I.; Garcia-Pelegrin, E.; Gould, K.; Greggor, A. L.; Izawa, E.-I.; Kelly, D. M.; Li, Z.; Luo, Y.; Luong, L. B.; Massen, J. J. M.; Neider, A.; Reber, S. A.; Schiestl, M.; Seguchi, A.; Sepehri, P.; Stevens, J. R.; Taylor, A. H.; Wang, L.; Wolff, L. M.; Zhang, Y.; Clayton, N. S.
10.1101/2021.07.27.453788 — animal behavior and cognition — Posted on 2021-07-27
637 Water-soluble tocopherol derivatives inhibit SARS-CoV-2 RNA-dependent RNA polymerase
Pacl, H. T.; Tipper, J. L.; Sevalkar, R. R.; Crouse, A.; Crowder, C.; UAB Precision Medicine Institute, ; Ahmad, S.; Ahmad, A.; Holder, G. D.; Kuhlman, C. J.; Chinta, K. C.; Nadeem, S.; Green, T. J.; Petit, C. M.; Steyn, A. J.; Might, M.; Harrod, K. S.
10.1101/2021.07.13.449251 — microbiology — Posted on 2021-07-27
641 Sexually distinct song cultures in a songbird metapopulation
Webb, W. H.; Roper, M. M.; Pawley, M. D.; Fukuzawa, Y.; Harmer, A. M.; Brunton, D. H.
10.1101/2021.07.05.451205 — animal behavior and cognition — Posted on 2021-07-27
642 Segmenting biological specimens from photos to understand the evolution of UV plumage in passerine birds
He, Y.; Cooney, C. R.; Varley, Z. K.; Nouri, L. O.; Moody, C. J. A.; Jardine, M. D.; Maddock, S.; Thomas, G. H.
10.1101/2021.07.22.453339 — evolutionary biology — Posted on 2021-07-27
643 Quantitative Profiling of Adaptation to Cyclin E Overproduction
Limas, J. C.; Littlejohn, A. N.; House, A. M.; Kedziora, K. M.; Fleifel, D.; Mouery, B. L.; Walens, A.; Aleman, M. M.; Dominguez, D.; Cook, J. G.
10.1101/2021.07.26.453751 — cell biology — Posted on 2021-07-27
649 De novo macrocyclic peptides for inhibiting, stabilising and probing the function of the Retromer endosomal trafficking complex
Chen, K.-E.; Guo, Q.; Hill, T. A.; Cui, Y.; Kendall, A. K.; Yang, Z.; Hall, R. J.; Healy, M.; Sacharz, J.; Norwood, S. J.; Fonseka, S.; Xie, B.; Reid, R. C.; Leneva, N.; Parton, R. G.; Ghai, R.; Stroud, D. A.; Fairlie, D. P.; Suga, H.; Jackson, L. P.; Teasdale, R. D.; Passioura, T.; Collins, B. M.
10.1101/2020.12.03.410779 — biochemistry — Posted on 2021-07-27
652 Genetic loci of the R. anatipestifer serotype discovered by Pan-GWAS and its application for the development of a multiplex PCR serotyping method
Yang, Z.; Yang, X.; Wang, M.; Jia, R.; Chen, S.; Liu, M.; Zhao, X.; Yang, Q.; Wu, Y.; Zhang, S.; Ou, X.; Mao, S.; Gao, Q.; Sun, D.; Zhu, D.; Cheng, A.
10.1101/2021.07.26.453894 — genomics — Posted on 2021-07-26
653 Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation
Fuchs, S.; Garrood, W. T.; Beber, A.; Hammond, A.; Galizi, R.; Gribble, M.; Morselli, G.; Hui, T.-Y. J.; Willis, K.; Kranjc, N.; Burt, A.; Nolan, T.; Crisanti, A.
10.1101/2021.07.26.453797 — genetics — Posted on 2021-07-26
656 Joint interactions with humans may pose a higher risk of zoonotic outbreaks than interactions with conspecifics among wildlife populations at human-wildlife interfaces
Balasubramaniam, K. N.; Aiempichitkijkarn, N.; Kaburu, S. S. K.; Marty, P. R.; Beisner, B. A.; Bliss-Moreau, E.; Arlet, M. E.; Atwill, E. R.; McCowan, B.
10.1101/2021.07.19.452944 — ecology — Posted on 2021-07-26
657 Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production
Hulme, B.; Geyer, K.; Forde-Thomas, J.; Padalino, G.; Phillips, D.; Ittiprasert, W.; Karinshak, S.; Mann, V.; Chalmers, I.; Brindley, P.; Hokke, C.; Hoffmann, K. F.
10.1101/2021.07.26.453800 — molecular biology — Posted on 2021-07-26
658 Profound structural conservation of chemically cross-linked HIV-1 envelope glycoprotein experimental vaccine antigens
Martin, G.; Russell, R. A.; Mundsperger, P.; Harris, S. L.; Li Jovanoska, L.; Farache Trajano, L.; Schiffner, T.; Fabian, K.; Tolazzi, M.; Scarlatti, G.; McFarlane, L. R.; Cheeseman, H.; Aldon, Y.; van Breemen, M. J.; Sliepen, K.; Katinger, D.; Kunert, R.; Sanders, R.; Shattock, R.; Ward, A.; Sattentau, Q. J.
10.1101/2021.07.26.453798 — molecular biology — Posted on 2021-07-26
659 ADAP1 promotes latent HIV-1 reactivation by selectively tuning a T cell signaling-transcriptional axis
Ramirez, N. G.; Lee, J.; Zheng, Y.; Li, L.; Dennis, B.; Chen, D.; Challa, A.; Planelles, V.; Westover, K. D.; Alto, N.; D'Orso, I.
10.1101/2021.07.26.453250 — microbiology — Posted on 2021-07-26
663 Cell-type specific innate immune responses shape rabies virus tropism
Feige, L.; Kozaki, T.; Dias de Melo, G.; Guillemot, V.; Larrous, F.; Ginhoux, F.; Bourhy, H.
10.1101/2021.07.26.453802 — microbiology — Posted on 2021-07-26
665 CAR/CXCR5-T cell immunotherapy is safe and potentially efficacious in promoting sustained remission of SIV infection
Pampusch, M. S.; Abdelaal, H. M.; Cartwright, E. K.; Molden, J. S.; Davey, B. C.; Sauve, J. D.; Rendahl, A. K.; Rakasz, E. G.; Connick, E.; Berger, E. A.; Skinner, P. J.
10.1101/2021.07.26.453803 — immunology — Posted on 2021-07-26
666 Anipose: a toolkit for robust markerless 3D pose estimation
Karashchuk, P.; Rupp, K. L.; Dickinson, E. S.; Walling-Bell, S.; Sanders, E.; Azim, E.; Brunton, B.; Tuthill, J. C.
10.1101/2020.05.26.117325 — neuroscience — Posted on 2021-07-26
668 Prolonged Pain Reliably Slows Peak Alpha Frequency by Reducing Fast Alpha Power
Furman, A. J.; Prokhorenko, M.; Keaser, M. L.; Zhang, J.; Chen, S.; Mazaheri, A.; Seminowicz, D. A.
10.1101/2021.07.22.453260 — neuroscience — Posted on 2021-07-26
669 Recording and neural circuit-based manipulation of the maternal oxytocin pulses in mice
Yukinaga, H.; Hagihara, M.; Tsujimoto, K.; Chiang, H.-L.; Kato, S.; Kobayashi, K.; Miyamichi, K.
10.1101/2021.07.26.453888 — neuroscience — Posted on 2021-07-26
674 Coil-to-Helix Transition at the Nup358-BicD2 Interface Activates BicD2 for Dynein Recruitment
Gibson, J. M.; Cui, H.; Ali, M. Y.; Zhao, X.; Debler, E. W.; Zhao, J.; Trybus, K. M.; Solmaz, S. R.; Wang, C.
10.1101/2021.05.06.443034 — biophysics — Posted on 2021-07-26
677 Protein Kinase C gamma Mutations Drive Spinocerebellar Ataxia Type 14 by Impairing Autoinhibition
Pilo, C. A.; Kornev, A. P.; Baffi, T. R.; Kunkel, M. T.; Malfavon, M.; Chen, D.-H.; Huang, L.-C.; Longman, C.; Kannan, N. A.; Raskind, W. H.; Gonzalez, D. J.; Taylor, S. S.; Gorrie, G.; Newton, A. C.
10.1101/2021.06.24.449810 — biochemistry — Posted on 2021-07-26
680 Sexually distinct song cultures in a songbird metapopulation
Webb, W. H.; Roper, M. M.; Pawley, M. D.; Fukuzawa, Y.; Harmer, A. M.; Brunton, D. H.
10.1101/2021.07.05.451205 — animal behavior and cognition — Posted on 2021-07-26
682 Hidden genetic variation in plasticity increases the potential to adapt to novel environments
Walter, G. M.; Clark, J.; Terranova, D.; Cozzolino, S.; Cristaudo, A.; Hiscock, S. J.; Bridle, J. R.
10.1101/2020.10.26.356451 — evolutionary biology — Posted on 2021-07-26
686 Retinoic acid fluctuation activates an uneven, direction-dependent network-wide robustness response in early embryogenesis
Parihar, M.; Bendelac-Kapon, L.; Gur, M.; Abbou, T.; Belorkar, A.; Achanta, S.; Kinberg, K.; Vadigepalli, R.; Fainsod, A.
10.1101/2020.07.15.203794 — developmental biology — Posted on 2021-07-26
687 Modeling lung cell development using human pluripotent stem cells
Ngan, Z.; Quach, H.; Dierolf, J.; Laselva, O.; Lee, J.-A.; Huang, E. N.; Mangos, M.; Xia, S.; Wong, A. P.
10.1101/2021.07.16.452691 — developmental biology — Posted on 2021-07-26
690 Rabies virus with a destabilization domain added to its nucleoprotein spreads between neurons only if the domain is removed
Jin, L.; Matsuyama, M.; Sullivan, H. A.; Zhu, M.; Lavin, T. K.; Hou, Y.; Lea, N. E.; Pruner, M. T.; Dam Ferdinez, M. L.; Wickersham, I. R.
10.1101/550640 — neuroscience — Posted on 2021-07-26
692 Asymmetric learning facilitates human inference of transitive relations
Ciranka, S.; Linde-Domingo, J.; Padezhki, I.; Wicharz, C.; Wu, C. M.; Spitzer, B.
10.1101/2021.04.03.437766 — neuroscience — Posted on 2021-07-26
695 A Wnt/β-catenin signaling driven adipocyte population required for beiging and glucose homeostasis
Liu, Z.; Chen, T.; Zhang, S.; Yang, T.; Gong, Y.; deng, H.-W.; Bai, D.; Tian, W.; Chen, Y.
10.1101/2021.01.14.426702 — physiology — Posted on 2021-07-26
696 PEGR: a flexible management platform for reproducible epigenomic and genomic research
Shao, D.; Kellogg, G.; Nematbakhsh, A.; Kuntala, P.; Mahony, S.; Pugh, B. F.; Lai, W. K.
10.1101/2021.07.26.453821 — bioinformatics — Posted on 2021-07-26
698 Resistance, resilience, and functional redundancy of freshwater bacterioplankton communities facing a gradient of agricultural stressors in a mesocosm experiment
Barbosa da Costa, N.; Fugere, V.; Hebert, M.-P.; Xu, C. C. Y.; Barrett, R. D. H.; Beisner, B.; Bell, G.; Yargeau, V.; Fussmann, G. F.; Gonzalez, A.; Shapiro, B. J.
10.1101/2020.04.12.038372 — ecology — Posted on 2021-07-26
700 MYC hyperactivates WNT signaling in APC/CTNNB1-mutated colorectal cancer cells through miR-92a-dependent repression of DKK3
Sehgal, P.; Lanauze, C.; Wang, X.; Hayer, K. E.; Torres-Diz, M.; Sela, Y.; Stanger, B. Z.; Lengner, C. J.; Thomas-Tikhonenko, A.
10.1101/2021.07.26.453875 — cancer biology — Posted on 2021-07-26
701 The Alzheimer's gene SORL1 is a key regulator of endosomal recycling in human neurons
Mishra, S.; Knupp, A.; Szabo, M.; Kinoshita, C.; Hailey, D. W.; Wang, Y.; Young, J. E.
10.1101/2021.07.26.453861 — cell biology — Posted on 2021-07-26
702 Selfish bacteria are active throughout the water column of the ocean
Giljan, G.; Brown, S.; Lloyd, C. C.; Ghobrial, S.; Amann, R.; Arnosti, C.
10.1101/2021.07.26.453833 — microbiology — Posted on 2021-07-26
703 Effect of stimulation time on the expression of human macrophage polarization markers
Unuvar Purcu, D.; Korkmaz, A.; Gunalp, S.; Helvaci, D. G.; Erdal, Y.; Dogan, Y.; Wingender, G.; Sag, D.
10.1101/2021.07.26.453762 — immunology — Posted on 2021-07-26
707 Trehalose induces tomato defenses and increases drought tolerance and bacterial wilt disease resistance
MacIntyre, A. M.; Meline, V.; Gorman, Z.; Augustine, S. P.; Dye, C. J.; Hamilton, C. D.; Iyer-Pascuzzi, A. S.; Kolomiets, M. V.; McCulloh, K. A.; Allen, C.
10.1101/2021.07.26.453814 — plant biology — Posted on 2021-07-26
710 Protection of human ACE2 transgenic Syrian hamsters from SARS CoV-2 variants by human polyclonal IgG from hyper-immunized transchromosomic bovines
Gilliland, T.; Liu, Y.; Li, R.; Dunn, M.; Cottle, E.; Terada, Y.; Ryckman, Z.; Alcorn, M.; Vasilatos, S.; Lundy, J. D.; Larson, D.; Wu, H.; Luke, T.; Bausch, C.; Egland, K.; Sullivan, E.; Wang, Z.; Klimstra, W.
10.1101/2021.07.26.453840 — microbiology — Posted on 2021-07-26
718 Correlational networking guides the discovery of cryptic proteases for lanthipeptide maturation
Xue, D.; Older, E. A.; Zhong, Z.; Shang, Z.; Chen, N.; Walla, M. D.; Dong, S.-H.; Tang, X.; Nagarkatti, P.; Nagarkatti, M.; Li, Y.-X.; Li, J.
10.1101/2021.07.26.453782 — biochemistry — Posted on 2021-07-26
722 FH loss in RPE cells causes retinal degeneration in a human RPE-porcine retinal explant co-culture model
Armento, A.; Murali, A.; Marzi, J.; Arango-Gonzalez, B.; Kilger, E.; Clark, S. J.; Schenke-Layland, K.; Ramlogan-Steel, C. A.; Steel, J. C.; Ueffing, M.
10.1101/2021.07.26.453778 — cell biology — Posted on 2021-07-26
723 Increased aerosol transmission for B.1.1.7 (alpha variant) over lineage A variant of SARS-CoV-2
Port, J.; Yinda, K. C.; Avanzato, V.; Schulz, J.; Holbrook, M.; van Doremalen, N.; Shaia, C.; Fischer, R.; Munster, V.
10.1101/2021.07.26.453518 — microbiology — Posted on 2021-07-26
725 Temporal Dynamics of HCMV Gene Expression in Lytic and Latent Infections
Rozman, B.; Kitsberg, Y.; Nachshon, A.; Schwartz, M.; Stern-Ginossar, N.
10.1101/2021.07.26.453763 — microbiology — Posted on 2021-07-26
726 Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralising SARS-CoV-2 nanobodies
Hanke, L.; Sheward, D. J.; Pankow, A.; Perez Vidakovics, L.; Karl, V.; Kim, C.; Urgard, E.; Smith, N. L.; Astorga-Wells, J.; Ekström, S.; Coquet, J. M.; McInerney, G. M.; Murrell, B.
10.1101/2021.07.25.453673 — immunology — Posted on 2021-07-26
728 Immunization with synthetic SARS-CoV-2 S glycoprotein virus-like particles protects Macaques from infection
Sulbaran, G.; Maisonnasse, P.; Amen, A.; Guilligay, D.; Bosquet, N.; Burger, J. A.; Poniman, M.; Buisson, M.; Dylon, S. D.; Naninck, T.; Lemaitre, J.; Gros, W.; Gallouet, A.-S.; Marlin, R.; Bouillier, C.; Contreras, V.; Relouzat, F.; Fenel, D.; Thepaut, M.; Bally, I.; Thielens, N.; Fieschi, F.; Schoehn, G.; van der Werf, S.; van Gils, M.; Sandres, R. W.; Poignard, P.; Le Grand, R.; Weissenhorn, W.
10.1101/2021.07.26.453755 — immunology — Posted on 2021-07-26
729 Regulatory start-stop elements in 5' untranslated regions pervasively modulate translation
Rendleman, J.; Mohammad, M. P.; Pressler, M.; Maity, S.; Hronova, V.; Gao, Z.; Herrmannova, A.; Lei, A.; Allgoewer, K.; Sultanov, D.; Hinckley, W. E.; Szkop, K.; Topisirovic, I.; Larsson, O.; Hatzoglou, M.; Valasek, L. S.; Vogel, C.
10.1101/2021.07.26.453809 — systems biology — Posted on 2021-07-26
731 The peroxisomal transporter ABCD3 plays a major role in dicarboxylic fatty acid metabolism
Ranea-Robles, P.; Chen, H.; Stauffer, B.; Yu, C.; Bhattacharya, D.; Friedman, S. L.; Puchowicz, M.; Houten, S.
10.1101/2021.07.26.452046 — physiology — Posted on 2021-07-26
735 The structural role of bacterial eDNA in the formation of biofilm streamers
Secchi, E.; Savorana, G.; Vitale, A.; Eberl, L.; Stocker, R.; Rusconi, R.
10.1101/2021.07.26.453754 — biophysics — Posted on 2021-07-26
736 Mutations in two SARS-CoV-2 variants of concern reflect two distinct strategies of antibody escape
Fiedler, S.; Denninger, V.; Morgunov, A. S.; Ilsley, A.; Worth, R.; Meisl, G.; Xu, C. K.; Piziorska, M. A.; Ricci, F.; Malik, A. Y.; Devenish, S. R. A.; Schneider, M. M.; Kosmoliaptsis, V.; Aguzzi, A.; Iwasaki, A.; Fiegler, H.; Knowles, T. P. J.
10.1101/2021.07.23.453327 — biochemistry — Posted on 2021-07-26
737 N-glycosylation profiles of the SARS-CoV-2 spike D614G mutant and its ancestral protein characterized by advanced mass spectrometry
Wang, D.; Zhou, B.; Keppel, T.; Solano, M.; Baudys, J.; Goldstein, J.; Finn, M. G.; Fan, X.; Chapman, A. P.; Bundy, J.; Woolfitt, A. R.; Osman, S.; Pirkle, J. L.; Wentworth, D. E.; Barr, J. R.
10.1101/2021.07.26.453787 — biochemistry — Posted on 2021-07-26
738 NMR spectroscopy of a single mammalian embryo
Sivelli, G.; Conley, G. M.; Herrera, C.; Marable, K.; Rodriguez, K.; Bollwein, H.; Sudano, M.; Brugger, J.; Simpson, A.; Boero, G.; Marco, G.
10.1101/2021.07.26.453772 — biochemistry — Posted on 2021-07-26
739 COPILOT: a Containerised wOrkflow for Processing ILlumina genOtyping daTa
Patel, H.; Lee, S.-H.; Breen, G.; Menzel, S.; Ojewunmi, O.; Dobson, R.
10.1101/2021.07.26.453753 — genomics — Posted on 2021-07-26
741 Unraveling three-dimensional chromatin structural dynamics during spermatogonial differentiation
Zheng, Y.; Zhang, L.; Jin, L.; Zhang, P.; Li, F.; Guo, M.; Gao, Q.; Zeng, Y.; Li, M.; Zeng, W.
10.1101/2021.07.26.453830 — developmental biology — Posted on 2021-07-26
742 The extracellular matrix gene, Svep1, orchestrates airway patterning and the transition from lung branching morphogenesis to alveolar maturation in the mouse
Foxworth, N.; Wells, J.; Ocana-Lopez, S.; Muller, S.; Denegre, J.; Palmer, K.; McGee, T.; Memishian, W.; Murray, S. A.; Donahoe, P. K.; Bult, C. J.; Loscertales, M.
10.1101/2021.07.26.453586 — developmental biology — Posted on 2021-07-26
743 SARS-CoV-2 Delta variant pathogenesis and host response in Syrian hamsters
Mohandas, S.; Yadav, P. D.; Shete, A. A.; Nyayanit, D.; Sapkal, G. N.; Lole, K.; Gupta, N.
10.1101/2021.07.24.453631 — molecular biology — Posted on 2021-07-26
755 Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling
Griffiths, S. C.; Tan, J.; Wagner, A.; Blazer, L. L.; Adams, J. J.; Sidhu, S. S.; Siebold, C.; Ho, H.-Y. H.
10.1101/2021.07.26.453829 — biochemistry — Posted on 2021-07-26
756 Barcoded RH-seq illuminates the complex genetic basis of yeast thermotolerance
Abrams, M. B.; Chuong, J. N.; AlZaben, F.; Dubin, C. A.; Skerker, J. M.; Brem, R. B.
10.1101/2021.07.26.453780 — evolutionary biology — Posted on 2021-07-26
758 Identification of a new family of "megaphages" that are abundant in the marine environment
Michniewski, S.; Rihtman, B.; Cook, R.; Jones, M.; Wilson, W.; Scanlan, D. D.; Millard, A.
10.1101/2021.07.26.453748 — microbiology — Posted on 2021-07-26
759 A highly conserved lipase deacylates oxidized phospholipids and ameliorates acute lung injury
Zou, B.; Goodwin, M.; Saleem, D.; Jiang, W.; Tang, J.; Chu, Y.; Munford, R. S.; Lu, M.
10.1101/2021.07.26.453786 — immunology — Posted on 2021-07-26
761 EXPRESSION OF A SECRETABLE, CELL-PENETRATING CDKL5 PROTEIN ENHANCES THE EFFICACY OF AAV VECTOR-MEDIATED GENE THERAPY FOR CDKL5 DEFICIENCY DISORDER.
Medici, G.; Tassinari, M.; Galvani, G.; Bastianini, S.; Gennaccaro, L.; Loi, M.; Fuchs, C.; Mottolese, N.; Alvente, S.; Berteotti, C.; Bagget, H. R.; Zoccoli, G.; Giustetto, M.; Muotri, A. R.; Nakai, H.; Trazzi, S.; Ciani, E.
10.1101/2021.07.26.453746 — neuroscience — Posted on 2021-07-26
764 Impact of neurite alignment on organelle motion.
Mytiliniou, M.; Wondergem, J. A. J.; Schmidt, T.; Heinrich, D.
10.1101/2021.07.26.453779 — biophysics — Posted on 2021-07-26
766 Accelerated epigenetic aging and inflammatory/immunological profile (ipAGE) in patients with chronic kidney disease
Yusipov, I.; Kondakova, E.; Kalyakulina, A.; Krivonosov, M.; Lobanova, N.; Bacalini, M. G.; Franceschi, C.; Vedunova, M.; Ivanchenko, M.
10.1101/2021.07.23.453588 — bioinformatics — Posted on 2021-07-26
768 Fusion-oncogenes are associated with increased metastatic capacity and persistent disease in pediatric thyroid cancers
Franco, A. T.; Ricarte-Filho, J. C.; Isaza, A.; Jones, Z.; Jain, N.; Mostoufi-Moab, S.; Surrey, L.; Laetsch, T. W.; Li, M. M.; DeHart, J. C.; Reichenberger, E.; Taylor, D.; Kazahaya, K.; Adzick, N. S.; Bauer, A. J.
10.1101/2021.07.23.453235 — genetics — Posted on 2021-07-26
769 The northern gene flow into southeastern East Asians inferred from genome-wide array genotyping
He, G.; Li, Y.; Zou, X.; Yeh, H.-Y.; Tang, R.; Wang, P.; Bai, J.; Yang, X.; Wang, Z.; Guo, J.; Chen, J.; Chen, J.; Yang, M.; Zhao, J.; Sun, J.; Zhu, K.; Ma, H.; Wang, R.; Yang, W.; Hu, R.; Wei, L.; Wang, M.; Chen, G.; Wang, C.-C.
10.1101/2021.07.25.453681 — genetics — Posted on 2021-07-26
770 Quantitative Profiling of Adaptation to Cyclin E Overproduction
Limas, J. C.; Littlejohn, A. N.; House, A. M.; Kedziora, K. M.; Fleifel, D.; Mouery, B. L.; Walens, A.; Aleman, M. M.; Dominguez, D.; Cook, J. G.
10.1101/2021.07.26.453751 — cell biology — Posted on 2021-07-26
772 Inhibition of striatal SEZ6 by miR-3594-5p is a drug-specific marker for late-stage heroin intake escalation
Lenoir, M.; Bondi, I.; Clemenceau, L.; Nondier, I.; Balle, M.; Jacques, S.; Duche, A.; Canestrelli, C.; Martin-Lanneree, S.; Mouillet-Richard, S.; Gunnersen, J. M.; Ahmed, S. H.; Marie, N.; Noble, F.
10.1101/2021.07.26.453355 — neuroscience — Posted on 2021-07-26
778 AGO1 regulates major satellite transcripts and H3K9me3 distribution at pericentromeric regions in mESCs
Mueller, M.; Faeh, T.; Schaefer, M.; Luitz, J.; Stalder, P.; Arora, R.; Ngondo, R. P.; Ciaudo, C.
10.1101/2021.07.26.453733 — cell biology — Posted on 2021-07-26
779 LAMP2A regulates the loading of proteins into exosomes.
Ferreira, J. V.; da Rosa Soares, A.; Ramalho, J. S.; Carvalho, C. M.; Cardoso, M. H.; Pintado, P.; Carvalho, A. S.; Beck, H. C.; Matthiesen, R.; Zuzarte, M.; Girao, H.; van Niel, G.; Pereira, P.
10.1101/2021.07.26.453637 — cell biology — Posted on 2021-07-26
782 Opposing roles of blood-borne monocytes and tissue-resident macrophages in limbal stem cell damage after ocular injury
Zhou, C.; Lei, F.; Mittermaier, M.; Ksander, B.; Dana, R.; Dohlman, C. H.; Vavvas, D. G.; Chodosh, J.; Paschalis, E. I.
10.1101/2021.07.25.453707 — immunology — Posted on 2021-07-26
787 Dynamics of SARS-CoV-2 mutations reveals regional-specificity and similar trends of N501 and High-Frequency mutation N501Y in different levels of control measures
Justo Arevalo, S.; Zapata Sifuentes, D.; Huallpa, C. J.; Landa Bianchi, G.; Castillo Chavez, A.; Garavito-Salini Casas, R.; Uribe Calampa, C. S.; Uceda-Campos, G.; Pineda Chavarria, R.
10.1101/2021.06.01.446571 — genomics — Posted on 2021-07-26
788 The first crested duck genome reveals clues to genetic compensation and crest cushion formation
Chang, G.; Yuan, X.; Guo, Q.; Bai, H.; Cao, X.; Liiu, M.; Wang, Z.; Li, B.; Wang, S.; Jiang, Y.; Wang, Z.; Zhang, Y.; Xu, Q.; Song, Q.; Pan, R.; Zheng, S.; Qiu, L.; Gu, T.; Wu, X.; Bi, Y.; Cao, Z.; Zhang, Y.; Chen, Y.; Li, H.; Liu, J.-F.; Dai, W.; Chen, G.
10.1101/2021.07.25.452189 — genomics — Posted on 2021-07-26
790 Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) Up to 15 Months Post-Infection
Patterson, B.; Francisco, E. B.; Yogendra, R.; Long, E.; Pise, A.; Rodrigues, H.; Hall, E.; Herrera, M.; Parikh, P.; Guevara-Coto, J.; Triche, T.; Scott, P.; Hekmati, S.; Maglinte, D.; Chang, X.; Rodriguez, R.; Mora, J.
10.1101/2021.06.25.449905 — immunology — Posted on 2021-07-26
791 The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2
Cathcart, A. L.; Havenar-Daughton, C.; Lempp, F. A.; Ma, D.; Schmid, M.; Agostini, M. L.; Guarino, B.; Di iulio, J.; Rosen, L.; Tucker, H.; Dillen, J.; Subramanian, S.; Sloan, B.; Bianchi, S.; Wojcechowskyj, J.; Zhou, J.; Kaiser, H.; Chase, A.; Lauron, E.; Montiel-Ruiz, M.; Spreafico, R.; Noack, J.; Czudnochowski, N.; Sahakyan, A.; Pinto, D.; Saliba, C.; Delotta, E.; Park, A.; Cameroni, E.; Ledoux, S.; Werts, A.; Colas, C.; Soriaga, L.; Telenti, A.; Purcell, L. A.; Hwang, S.; Snell, G.; Virgin, H. W.; Corti, D.; Hebner, C. M.
10.1101/2021.03.09.434607 — immunology — Posted on 2021-07-26
792 CD8+ T cell signature in acute SARS-CoV-2 infection identifies memory precursors
Adamo, S.; Michler, J.; Zurbuchen, Y.; Cervia, C.; Taeschler, P.; Raeber, M. E.; Baghai Sain, S.; Nilsson, J.; Moor, A.; Boyman, O.
10.1101/2021.07.22.453029 — immunology — Posted on 2021-07-26
797 Oncogenic c-Myc induces replication stress by increasing cohesins chromatin occupancy
Peripolli, S.; Singh, T.; Patel, H.; Meneguello, L.; Kiso, K.; Thorpe, P. H.; Bertoli, C.; de Bruin, R. A. M.
10.1101/2021.07.25.453647 — cancer biology — Posted on 2021-07-26
806 Genome Profiling of SARS-CoV-2 in Indonesia, ASEAN and the Neighbouring East Asian Countries: Features, Challenges and Achievements
Cahyani, I.; Putro, E. W.; Ridwanuloh, A. M.; Wibowo, S.; Hariyatun, H.; Syahputra, G.; Akbariani, G.; Utomo, A. R.; Ilyas, M.; Loose, M. W.; Kusharyoto, W.; Indonesian SARS-CoV-2 Genomics Surveillance Network, ; Susanti, S.
10.1101/2021.07.06.451270 — genomics — Posted on 2021-07-26
807 Identification of a divergent basal body assembly protein involved in land plant spermatogenesis
Koshimizu, S.; Minamino, N.; Nishiyama, T.; Yoro, E.; Ebine, K.; sakakibara, k.; Ueda, T.; Yano, K.
10.1101/2021.07.25.453666 — evolutionary biology — Posted on 2021-07-26
808 Bats host the most virulent--but not the most dangerous--zoonotic viruses
Guth, S.; Mollentze, N.; Renault, K.; Streicker, D.; Visher, E.; Boots, M.; Brook, C. E.
10.1101/2021.07.25.453574 — ecology — Posted on 2021-07-26
809 Specialized subsets of innate-like T cells and dendritic cells protect from lethal pneumococcal infection in the lung
Murray, M. P.; Crosby, C. M.; Marcovecchio, P.; Hartmann, N.; Chandra, S.; Zhao, M.; Khurana, A.; Zahner, S. P.; Clausen, B. E.; Coleman, F. T.; Mizgerd, J. P.; Mikulski, Z.; Kronenberg, M.
10.1101/2021.07.25.453697 — immunology — Posted on 2021-07-26
818 A Combined Spectroscopic and Molecular Modeling Study on Structure-Function-Dynamics under Chemical Modification: Alpha-Chymotrypsin with Formalin Preservative
Biswas, P.; Adhikari, A.; Pal, U.; Mondal, S.; Mukherjee, D.; Ghosh, R.; Saha-Dasgupta, T.; Chowdhury, S. S.; Das, R.; Pal, S. K.
10.1101/2021.07.24.453635 — biophysics — Posted on 2021-07-26
823 Disentangling key species interactions in diverse and heterogeneous communities: A Bayesian sparse modeling approach
Weiss-Lehman, C.; Werner, C. M.; Bowler, C. H.; Hallett, L. M.; Mayfield, M. M.; Godoy, O.; Aoyama, L.; Barabas, g.; Chu, C.; Ladouceur, E.; Larios, L.; Shoemaker, L. G.
10.1101/2021.07.23.453227 — ecology — Posted on 2021-07-26
825 Whole body regeneration deploys a rewired embryonic gene regulatory network logic
Warner, J. F.; Johnston, H.; Amiel, A. R.; Nedoncelle, K.; Carvalho, J. E.; Röttinger, E.
10.1101/658930 — developmental biology — Posted on 2021-07-26
829 AlphaPept, a modern and open framework for MS-based proteomics
Strauss, M. T.; Bludau, I.; Zeng, W.-F.; Voytik, E.; Ammar, C.; Schessner, J.; Ilango, R.; Gill, M.; Meier, F.; Willems, S.; Mann, M.
10.1101/2021.07.23.453379 — bioinformatics — Posted on 2021-07-26
830 PatchPerPixMatch for Automated 3d Search of Neuronal Morphologies in Light Microscopy
Mais, L.; Hirsch, P.; Managan, C.; Wang, K.; Rokicki, K.; Svirskas, R. R.; Dickson, B. J.; Korff, W.; Rubin, G. M.; Ihrke, G.; Meissner, G. W.; Kainmueller, D.
10.1101/2021.07.23.453511 — bioinformatics — Posted on 2021-07-26
833 A network-based approach reveals the dysregulated transcriptional regulation in non-alcohol fatty liver disease
Yang, H.; Arif, M.; Yuan, M.; Li, X.; Shong, K.; Turkez, H.; Nielsen, J.; Uhlen, M.; Boren, J.; Zhang, C.; Mardinoglu, A.
10.1101/2021.07.24.453650 — systems biology — Posted on 2021-07-26
834 Functional metabolic phenotyping of human pancreatic ductal adenocarcinoma
Heid, I.; Karakaya, S.; Muench, C.; Lueong, S. S.; Winkelkotte, A. M.; Liffers, S. T.; Godfrey, L.; Cheung, P. F.; Savvatakis, K.; Topping, G. J.; Englert, F.; Kritzner, L.; Grashei, M.; Kunzke, T.; Sun, N.; Walch, A.; Tannapfel, A.; Viebahn, R.; Wolters, H.; Uhl, W.; Vangala, D.; Markus-Smeets, E.; Aarntzen, E. H. J. G.; Rauh, D.; Hoheisel, J.; Hellerschmied, D.; Hahn, S.; Schilling, F.; Braren, R.; Trajkovic-Arsic, M.; Siveke, J. T.
10.1101/2021.07.23.452145 — cancer biology — Posted on 2021-07-26
836 Segmenting biological specimens from photos to understand the evolution of UV plumage in passerine birds
He, Y.; Cooney, C. R.; Varley, Z. K.; Nouri, L. O.; Moody, C. J. A.; Jardine, M. D.; Maddock, S.; Thomas, G. H.
10.1101/2021.07.22.453339 — evolutionary biology — Posted on 2021-07-26
837 Tumour Suppressor Parafibromin/Hyrax Governs Cell Polarity and Centrosome Assembly in Neural Stem Cells
Deng, Q.; Wang, C.; Koe, C. T.; Heinen, J. P.; Tan, Y. S.; Li, S.; GONZALEZ, C.; Sung, W.-K.; Wang, H.
10.1101/2021.07.06.451232 — developmental biology — Posted on 2021-07-26
841 High-resolution simulations of chromatin folding at genomic rearrangements in malignant B-cells provide mechanistic insights on proto-oncogene deregulation
Rico, D.; Kent, D.; Mikulasova, A.; Karataraki, N.; Berlinguer-Palmini, R.; Walker, B. A.; Javierre, B. M.; Russell, L. J.; Brackley, C. A.
10.1101/2021.03.12.434963 — genomics — Posted on 2021-07-26
845 A prioritized and validated resource of mitochondrial proteins in Plasmodium identifies leads to unique biology
van Esveld, S. L.; Meerstein-Kessel, L.; Boshoven, C.; Baaij, J.; Barylyuk, K.; Coolen, J.; van Strien, J.; Duim, R. A. J.; Dutilh, B. E.; Garza, D. R.; Letterie, M.; Proellochs, N. I.; de Ridder, M. N.; Venkatasubramanian, P. B.; de Vries, L. E.; Waller, R. F.; Kooij, T. W. A.; Huynen, M. A.
10.1101/2021.01.22.427784 — bioinformatics — Posted on 2021-07-26
846 A yeast lysosomal biogenesis map uncovers the cargo spectrum of lysosomal protein targeting pathways
Eising, S.; Esch, B. M.; Waelte, M.; Vargas Duarte, P.; Walter, S.; Ungermann, C.; Bohnert, M.; Froehlich, F.
10.1101/2021.07.24.453616 — cell biology — Posted on 2021-07-26
848 BAI-Net: Individualized Human Cerebral Cartography using Graph Convolutional Network
Ma, L.; Zhang, Y.; Zhang, H.; Cheng, L.; Zhuo, J.; Shi, W.; Lu, Y.; Li, W.; Wang, J.; Yang, Z.; Fan, L.; Jiang, T.
10.1101/2021.07.15.452577 — neuroscience — Posted on 2021-07-26
856 Energetics but not development is impacted in coral embryos exposed to ocean acidification
Chille, E. E.; Strand, E. L.; Scucchia, F.; Schmidt, V.; Neder, M.; Sherman, M. O.; Mass, T.; Putnam, H. M.
10.1101/2021.07.19.452948 — physiology — Posted on 2021-07-25
857 A combined bioinformatics and LC-MS based approach for the development and benchmarking of a comprehensive database for CNS proteins in Lymnaea stagnalis
Wooller, S.; Anagnostopoulou, A.; Kuropka, B.; Crossley, M.; Benjamin, P. R.; Pearl, F.; Kemenes, I.; Kemenes, G.; Eravci, M.
10.1101/2021.05.03.442491 — bioinformatics — Posted on 2021-07-25
858 Modelling Human Gait using a Nonlinear Differential Equation
Schmalz, J.; Paul, D.; Shorter, K.; Schmalz, X.; Cooper, M.; Murphy, A.
10.1101/2021.03.16.435713 — bioengineering — Posted on 2021-07-25
862 The cold-drought tolerance trade-off in temperate woody plants constrains range size, but not range filling
Puglielli, G.; Tordoni, E.; Humphreys, A.; Kalwij, J. M.; Hutchings, M. J.; Laanisto, L.
10.1101/2021.07.24.453622 — ecology — Posted on 2021-07-25
865 Transcriptomic Analysis of Human Sensory Neurons in Painful Diabetic Neuropathy Reveals Inflammation and Neuronal Loss
Hall, B.; Macdonald, E.; Cassidy, M.; Yun, S.; Sapio, M.; Ray, P.; Doty, M.; Nara, P.; Burton, M. D.; Shiers, S.; Ray-Chaudhury, A.; Mannes, A. J.; Price, T. J.; Iadarola, M. J.; Kulkarni, A. B.
10.1101/2021.07.23.453576 — neuroscience — Posted on 2021-07-25
868 Reducing indoor particle exposure using mobile air purifiers - experimental and numerical analysis
Tobisch, A.; Springsklee, L.; Schaefer, L.-F.; Sussmann, N.; Lehmann, M. J.; Weis, F.; Zoellner, R.; Niessner, J.
10.1101/2021.07.23.453308 — biophysics — Posted on 2021-07-25
869 A community-based approach to image analysis of cells, tissues and tumors
CSBC/PS-ON Image Analysis Working Group, ; Vizcarra, J. C.; Burlingame, E. A.; Hug, C. B.; Goltsev, Y.; White, B. S.; Tyson, D. R.; Sokolov, A.
10.1101/2021.07.22.451363 — bioinformatics — Posted on 2021-07-25
870 Capturing variation in metagenomic assembly graphs with MetaCortex
Martin, S.; Ayling, M.; Patrono, L.; Caccamo, M.; Murcia, P.; Leggett, R. M.
10.1101/2021.07.23.453484 — bioinformatics — Posted on 2021-07-25
871 Green self-immolative polymer: molecular antenna to collect and propagate the signal for zymogen activation
Montasell, M. C.; Monge, P.; Carmali, S.; Mesquita, L.; Andersen, D.; Lovschall, K.; Sogaard, A.; Kristensen, M.; Pütz, J.; Zelikin, A. N.
10.1101/2021.07.25.453687 — biochemistry — Posted on 2021-07-25
872 Functional asymmetry and chemical reactivity of CsoR family persulfide sensors
Fakhoury, J.; Zhang, Y.; Edmonds, K. A.; Bringas, M.; Luebke, J.; Gonzalez-Gutierrez, G.; Capdevila, D. A.; Giedroc, D. P.
10.1101/2021.07.25.453692 — biochemistry — Posted on 2021-07-25
876 Large positive ecological changes of small urban greening actions
Mata, L.; Hahs, A. K.; Palma, E.; Backstrom, A.; King, T.; Olson, A. R.; Renowden, C.; Smith, T. R.; Vogel, B.
10.1101/2021.07.23.453468 — ecology — Posted on 2021-07-25
877 Evolution of a chordate-specific mechanism for myoblast fusion
Zhang, H.; Shang, R.; Kim, K.; Zheng, W.; Johnson, C. J.; Sun, L.; Niu, X.; Liu, L.; Uyeno, T. A.; Zhou, J.; Liu, L.; Pei, J.; Fissette, S. D.; Green, S. A.; Samudra, S. P.; Wen, J.; Zhang, J.; Eggenschwiler, J.; Menke, D.; Bronner, M. E.; Grishin, N. V.; Li, W.; Ye, K.; Zhang, Y.; Stolfi, A.; Bi, P.
10.1101/2021.07.24.453587 — developmental biology — Posted on 2021-07-25
878 Assessing donor-to-donor variability in human intestinal organoid cultures
Mohammadi, S.; Morell-Perez, C.; Wright, C. W.; Wyche, T. P.; White, C. H.; Sana, T. R.; Lieberman, L. A.
10.1101/2021.07.23.453590 — developmental biology — Posted on 2021-07-25
879 A yeast lysosomal biogenesis map uncovers the cargo spectrum of lysosomal protein targeting pathways
Eising, S.; Esch, B. M.; Waelte, M.; Walter, S.; Ungermann, C.; Bohnert, M.; Froehlich, F.
10.1101/2021.07.24.453616 — cell biology — Posted on 2021-07-25
880 Eukaryotic genomes from a global metagenomic dataset illuminate trophic modes and biogeography of ocean plankton
Alexander, H.; Hu, S. K.; Krinos, A. I.; Pachiadaki, M.; Tully, B. J.; Neely, C. J.; Reiter, T.
10.1101/2021.07.25.453713 — microbiology — Posted on 2021-07-25
882 A distinct CD115- erythro-myeloid precursor present at the maternal-embryonic interface and in the bone marrow of adult mice
Tikoo, S.; Jain, R.; Martinez, B.; Song, R.; Wielscher, M.; Rizzetto, S.; Shaw, L. E.; Mitchell, A. J.; Torres-Pacheco, M. E.; Luciani, F.; Farlik, M.; Wong, J.; Jung, S.; Fraser, S. T.; Weninger, W.
10.1101/2021.07.24.453629 — immunology — Posted on 2021-07-25
883 Neuron-Glia Signaling Regulates the Onset of the Antidepressant Response
Yao, V.; Aly, A.; Kalik, S.; Gresack, J.; Wang, W.; Handler, A.; Schaefer, A.; Troyanskaya, O.; Greengard, P.; Chottekalapanda, R. U.
10.1101/2021.07.23.453443 — neuroscience — Posted on 2021-07-25
884 A distributed dopamine-gated circuit underpins reproductive state-dependent behavior in Drosophila females
Boehm, A. C.; Friedrich, A. B.; Bandow, P.; Siju, K. P.; Hunt, S.; Claussen, J.; Link, M.-H.; Hofmann, T. F.; Dawid, C.; Grunwald Kadow, I. C.
10.1101/2021.07.24.453623 — neuroscience — Posted on 2021-07-25
890 Estimation of Average Blood Glucose Values Based on Fructosamine Values
de Oliveira Andrade, L. J.; Bittencourt, A. M. V.; Moreno de Brito, L. F.; Matos de Oliveira, L.; Matos de Oliveira, G. C.
10.1101/2021.07.25.453711 — biochemistry — Posted on 2021-07-25
892 The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance
Dimitrova, D. G.; Brazane, M.; Pigeon, J.; Paolantoni, C.; Tao, Y.; Marchand, V.; Da Silva, B.; Schaefer, E.; Angelova, M. T.; Stark, Z.; Delatycki, M.; Dudding, T.; Gecz, J.; Placais, P.-Y.; Teysset, L.; Preat, T.; Piton, A.; Hassan, B. A.; Roignant, J.-Y.; Motorin, Y.; Carre, C.
10.1101/2021.02.06.430044 — genetics — Posted on 2021-07-25
893 Transcription and splicing dynamics during early Drosophila development
Prudencio, P.; Savisaar, R.; Rebelo, K.; Martinho, R. G.; Carmo-Fonseca, M.
10.1101/2020.11.05.367888 — molecular biology — Posted on 2021-07-25
894 Adapted protocol for Saccharibacteria co-cultivation: two new members join the club of Candidate Phyla radiation
Ibrahim, A.; Maatouk, M.; Rajaonison, A.; Zgheib, R.; Haddad, G.; Bou Khalil, J. Y.; Raoult, D.; Bittar, F.
10.1101/2021.07.23.453610 — microbiology — Posted on 2021-07-25
895 Social Reactivation of Fear Engrams Enhances Memory Recall
Finkelstein, A. B.; Leblanc, H.; Cole, R.; Gallerani, T.; Vieira, A.; Zaki, Y.; Ramirez, S.
10.1101/2021.01.07.425728 — neuroscience — Posted on 2021-07-25
900 PTEN mutant NSCLC require ATM to suppress pro-apoptotic signalling and evade radiotherapy
Fischer, T.; Hartmann, O.; Reissland, M.; Prieto-Garcia, C.; Klann, K.; Schuelein-Voelk, C.; Polat, B.; Gebhard-Hartmann, E.; Rosenfeldt, M.; Muench, C.; Flentje, M.; Diefenbacher, M. E.
10.1101/2021.07.24.453632 — cancer biology — Posted on 2021-07-25
902 In vitro and in vivo analysis of microvesicle-mediated metastasis using a bright, red-shifted bioluminescent reporter protein of extracellular vesicles
Zarea, A. A.; Perez, G. I.; Broadbent, D.; Dolgikh, B.; Bernard, M. P.; Withrow, A.; McGill, A.; Toomajian, V.; Thampy, L. K.; Harkema, J.; Walker, J. R.; Kirkland, T. A.; Bachmann, M. H.; Schmidt, J.; Kanada, M.
10.1101/2021.07.23.453512 — cancer biology — Posted on 2021-07-25
903 Knowledge Graph-based Recommendation Framework Identifies Novel Drivers of Resistance in EGFR mutant Non-small Cell Lung Cancer
Gogleva, A.; Polychronopoulos, D.; Pfeifer, M.; Poroshin, V.; Ughetto, M.; Sidders, B.; Ahdesmaki, M.; McDermott, U.; Papa, E.; Bulusu, K.
10.1101/2021.07.23.453506 — cancer biology — Posted on 2021-07-25
904 Widespread germline genetic heterogeneity of human ribosomal RNA genes
Fan, W.; Eklund, E.; Sherman, R. M.; Liu, H.; Pitts, S.; Ford, B.; NV, R.; Laiho, M.
10.1101/2021.07.21.453267 — bioinformatics — Posted on 2021-07-25
905 Motor Sequences - Separating The Sequence From The Motor. A longitudinal rsfMRI Study
Jaeger, A.-T. P.; Huntenburg, J. M.; Tremblay, S. A.; Schneider, U.; Grahl, S.; Huck, J.; Tardif, C. L.; Villringer, A.; Gauthier, C. J.; Bazin, P.-L.; Steele, C. J.
10.1101/2021.02.09.430495 — neuroscience — Posted on 2021-07-25
906 Strong and opponent contributions of dorsomedial striatal pathways to behavior depends on cognitive demands and task strategy
Bolkan, S.; Stone, I.; Pinto, L.; Ashwood, Z.; Garcia, J.; Herman, A.; Singh, P.; Bandi, A.; Cox, J.; Zimmerman, C.; Cho, J.; Engelhard, B.; Koay, S.; Pillow, J.; Witten, I.
10.1101/2021.07.23.453573 — neuroscience — Posted on 2021-07-25
909 Self-organized morphogenesis of a human neural tube in vitro by geometric constraints
Karzbrun, E.; Khankhel, A.; Megale, H.; Glasauer, S.; Wyle, Y.; Britton, G.; Warmflash, A.; Kosik, K. S.; Siggia, E.; Shraiman, B.; Streichan, S. J.
10.1101/2021.07.24.453659 — developmental biology — Posted on 2021-07-25
910 Glutamatergic dysfunction leads to a hyper-dopaminergic phenotype through deficits in short-term habituation: a mechanism for aberrant salience.
Panayi, M. C.; Boerner, T.; Jahans-Price, T.; Huber, A.; Sprengel, R.; Gilmour, G.; Sanderson, D. J.; Harrison, P. J.; Walton, M. E.; Bannerman, D. M.
10.1101/2021.07.23.453593 — neuroscience — Posted on 2021-07-25
911 Mechanosensitivity of nucleocytoplasmic transport
Andreu, I.; Granero, I.; Chahare, N.; Clein, K.; Molina Jordan, M.; Beedle, A. E. M.; Elosegui-Artola, A.; Trepat, X.; Raveh, B.; Roca-Cusachs, P.
10.1101/2021.07.23.453478 — biophysics — Posted on 2021-07-24
912 Toxin breakdown does not preclude the potential for defensive toxin use in a fruit fly
Douglas, T. E.; Beskid, S. G.; Gernand, C. E.; Nirtaut, B. E.; Tamsil, K. E.; Fitch, R. W.; Tarvin, R. D.
10.1101/2021.07.23.453507 — evolutionary biology — Posted on 2021-07-24
913 The desmin mutation R349P increases contractility and fragility of stem cell-generated muscle micro-tissues
Spoerrer, M.; Kah, D.; Gerum, R. C.; Reischl, B.; Huraskin, D.; Dessalles, C. A.; Schneider, W.; Goldmann, W. H.; Herrmann, H.; Thievessen, I.; Clemen, C. S.; Friedrich, O.; Hashemolhosseini, S.; Schroeder, R.; Fabry, B.
10.1101/2021.07.23.453481 — biophysics — Posted on 2021-07-24
916 Regulation of neuronal progenitor delamination by dynein-driven post-Golgi apical transport
Brault, J.-B.; Bardin, S.; Lampic, M.; Carpentieri, J.; Coquand, L.; Penisson, M.; Lachuer, H.; Victoria, G. S.; Baloul, S.; Boncompain, G.; Miserey-Lenkei, S.; Fraisier, V.; Francis, F.; Perez, F.; Goud, B.; Baffet, A. D.
10.1101/2021.07.23.453475 — cell biology — Posted on 2021-07-24
918 IFITM3 regulates virus-induced inflammatory cytokine production by titrating Nogo-B orchestration of TLR responses
Clement, M.; Forbester, J. L.; Marsden, M.; Sabberwal, P.; Wellington, D.; Dimonte, S.; Harcourt, K.; Clare, S.; Yin, Z.; Nobre, L.; Antrobus, R.; Jin, B.; Chen, M.; Makvandi-Nejad, S.; Lindborg, J. A.; Strittmatter, S. M.; Weekes, M. P.; Stanton, R. j.; Dong, T.; Humphreys, I.
10.1101/2021.07.23.453513 — immunology — Posted on 2021-07-24
920 Genomic rearrangements have consequences for introgression breeding as revealed by genome assemblies of wild and cultivated lentil species
Ramsay, L.; Koh, C. S.; Kagale, S.; Gao, D.; Kaur, S.; Haile, T.; Gela, T. S.; Chen, L.-A.; Cao, Z.; Konkin, D. J.; Toegelova, H.; Dolezel, J.; Rosen, B. D.; Stonehouse, R.; Humann, J. L.; Main, D.; Coyne, C. J.; McGee, R. J.; Cook, D. R.; Penmetsa, R. V.; Vandenberg, A.; Chan, C.; Banniza, S.; Edwards, D.; Bayer, P. E.; Batley, J.; Udupa, S. M.; Bett, K. E.
10.1101/2021.07.23.453237 — plant biology — Posted on 2021-07-24
922 Mapping drug-microenvironment-genetic interplay in CLL reveals trisomy 12 as a modulator of microenvironmental signals
Bruch, P.-M.; Giles, H.; Kolb, C.; Herbst, S. A.; Becirovic, T.; Roider, T.; Lu, J.; Scheinost, S.; Wagner, L.; Hüllein, J.; Berest, I.; Kriegsmann, M.; Kriegsmann, K.; Zgorzelski, C.; Dreger, P.; Zaugg, J. B.; Müller-Tidow, C.; Zenz, T.; Huber, W.; Dietrich, S.
10.1101/2021.07.23.453514 — cancer biology — Posted on 2021-07-24
923 An anti-ACVR1 antibody exacerbates heterotopic ossification by fibro/adipogenic progenitors in fibrodysplasia ossificans progressiva mice
Lees-Shepard, J. B.; Stoessel, S. J.; Chandler, J.; Bouchard, K.; Bento, P.; Apuzzo, L. N.; Devarakonda, P. M.; Hunter, J. W.; Goldhamer, D. J.
10.1101/2021.07.23.451471 — developmental biology — Posted on 2021-07-24
926 Principles of mRNA targeting via the Arabidopsism6A-binding protein ECT2
Arribas-Hernandez, L.; Rennie, S.; Koester, T.; Porcelli, C.; Lewinski, M.; Staiger, D.; Andersson, R.; Brodersen, P.
10.1101/2021.04.18.440342 — molecular biology — Posted on 2021-07-24
928 FTO suppresses STAT3 activation and modulates proinflammatory interferon-stimulated gene expression
McFadden, M. J.; Sacco, M. T.; Murphy, K. A.; Park, M.; Gokhale, N. S.; Somfleth, K. Y.; Horner, S. M. M.
10.1101/2021.07.23.453596 — molecular biology — Posted on 2021-07-24
929 Hundreds of viral families in the healthy infant gut
Shah, S. A.; Deng, L.; Thorsen, J.; Pedersen, A. G.; Dion, M. B.; Castro Mejia, J.; Silins, R.; Romme, F. O.; Sausset, R.; Ndela, E. O.; Hjemso, M. H.; Rasmussen, M. A.; Redgwell, T.; Vestergaard, G. A.; Zhang, Y.; Sorensen, S. J.; Bisgaard, H.; Enault, F.; Stokholm, J.; Moineau, S.; Petit, M.-A.; Nielsen, D. S.
10.1101/2021.07.02.450849 — microbiology — Posted on 2021-07-24
930 The transcription factor Zeb2 drives differentiation of age-associated B cells
Gu, S.; Han, X.; Yao, C.; Ding, H.; Zhang, J.; Hou, G.; Qu, B.; Zhou, H.; Ying, Z.; Ye, Z.; Qian, J.; Guo, Q.; Chen, S.; Vinuesa, C. G.; Dai, D.; Shen, N.
10.1101/2021.07.24.453633 — immunology — Posted on 2021-07-24
931 Structure of long-range direct and indirect spinocerebellar pathways as well as local spinal circuits mediating proprioception.
Pop, I. V.; Espinosa-Becerra, F.; Blevins, C. J.; Okafor, P. C.; Ogujiofor, O.; Goyal, M.; Mona, B.; Landy, M.; Dean, K. M.; Gurumurthy, C. M.; Lai, H. C.
10.1101/2020.08.17.254607 — neuroscience — Posted on 2021-07-24
933 DNA mismatch and damage detection using a FRET-based assay for monitoring the loading of multiple MutS sliding clamps
Kunetsky, V.; Storozhuk, O.; Brouwer, G.; Laffeber, C.; Dillingham, M. S.; Lebbink, J.; Friedhoff, P.
10.1101/2021.07.23.453479 — biochemistry — Posted on 2021-07-24
934 Sulfated host glycan recognition by carbohydrate sulfatases of the human gut microbiota
Luis, A. S.; Basle, A.; Byrne, D. P.; Wright, G. S.; London, J.; Chunsheng, J.; Karlsson, N.; Hansson, G. C.; Eyers, P. A.; Czjzek, M.; Barbeyron, T.; Yates, E. A.; Martens, E. C.; Cartmell, A.
10.1101/2021.07.23.453482 — biochemistry — Posted on 2021-07-24
935 Malaria parasite evades mosquito immunity by glutaminyl cyclase mediated protein modification
Kolli, S. K.; Molina-Cruz, A.; Araki, T.; Geurten, F. J. A. v.; Ramesar, J.; Chevalley-Maurel, S.; Kroeze, H. J.; Bezemer, S.; de Korne, C.; Withers, R.; Raytselis, N.; El Hebieshy, A. F.; Kim, R. Q.; Child, M.; Kakuta, S.; Hisaeda, H.; Kobayashi, H.; Annoura, T.; Hensbergen, P. J.; Franke-Fayard, B. M.; Barillas-Mury, C.; Scheeren, F. A.; Janse, C. J.
10.1101/2021.07.23.453408 — microbiology — Posted on 2021-07-24
936 The human neuronal receptor NgR1 bridges reovirus capsid proteins to initiate infection
Sutherland, D. M.; Strebl, M.; Koehler, M.; Welsh, O. L.; Yu, X.; Hu, L.; dos Santos Natividade, R.; Knowlton, J. J.; Taylor, G. M.; Moreno, R.; Woerz, P.; Lonergan, Z. L.; Aravamudhan, P.; Guzman-Cardozo, C.; Alsteens, D.; Wang, Z.; Prasad, B.; Stehle, T.; Dermody, T. S.
10.1101/2021.07.23.453469 — microbiology — Posted on 2021-07-24
938 SRS-FISH: High-Throughput Platform Linking Microbiome Function to Identity at the Single Cell Level
Ge, X.; Pereira, F. C.; Mitteregger, M.; Berry, D.; Zhang, M.; Wagner, M.; Cheng, J.-X.
10.1101/2021.07.23.453601 — microbiology — Posted on 2021-07-24
941 Orfamide-A-mediated bacterial-algal interactions involve specific Ca2+ signalling pathways
Hou, Y.; Bando, Y.; Carrasco Flores, D.; Hotter, V. S.; Schiweck, B.; Arndt, H.-D.; Mittag, M.
10.1101/2021.07.24.453618 — microbiology — Posted on 2021-07-24
949 High Sucrose Diets Contribute to Brain Angiopathy with Impaired Glucose Uptake, and Psychosis-related Higher Brain Dysfunctions in Mice
Hirai, S.; Miwa, H.; Tanaka, T.; Toriumi, K.; Kunii, Y.; Sakamoto, T.; Hino, M.; Izumi, R.; Nagaoka, A.; Yabe, H.; Nakamachi, T.; Shioda, S.; Dan, T.; Miyata, T.; Nishito, Y.; Shimbo, H.; Suzuki, K.; Miyashita, M.; Tomoda, T.; Takatoshi, H.; Horiuchi, J.; Itokawa, M.; Arai, M.; Okado, H.
10.1101/2020.02.14.939546 — neuroscience — Posted on 2021-07-24
950 Mapping Epigenetic Divergence in the Massive Radiation of Lake Malawi Cichlid Fishes
Vernaz, G.; Malinsky, M.; Svardal, H.; Du, M.; Tyers, A. M.; Santos, M. E.; Durbin, R.; Genner, M. J.; Turner, G. F.; Miska, E. A.
10.1101/2020.11.24.383034 — genomics — Posted on 2021-07-24
951 Sex-specific body mass ageing trajectories in adult Asian elephants
Lalande, L. D.; Lummaa, V.; Aung, H. H.; Htut, W.; Nyein, U. K.; Berger, V.; Briga, M.
10.1101/2020.12.17.423208 — evolutionary biology — Posted on 2021-07-24
954 MinION barcodes: biodiversity discovery and identification by everyone, for everyone
Srivathsan, A.; Lee, L.; Katoh, K.; Hartop, E.; Kutty, S. N.; Wong, J.; Yeo, D.; Meier, R.
10.1101/2021.03.09.434692 — ecology — Posted on 2021-07-24
955 Differential phase register of Hes1 oscillations with mitoses underlies cell-cycle heterogeneity in ER+ breast cancer cells.
Sabherwal, N.; Rowntree, A.; Marinopoulou, E.; Pettini, T.; Hourihane, S.; Thomas, R.; Kursawe, J.; Soto, X.; Papalopulu, N.
10.1101/2021.01.04.425227 — cell biology — Posted on 2021-07-24
956 Representation of Task Structure in Human Hippocampus and Orbitofrontal Cortex
Mizrak, E.; Bouffard, N.; Libby, L. A.; Boorman, E.; Ranganath, C.
10.1101/794305 — neuroscience — Posted on 2021-07-24
958 Phylogenomic analyses of echinoid diversification prompt a re-evaluation of their fossil record
Mongiardino Koch, N.; Thompson, J. R.; Hatch, A. S.; McCowin, M. F.; Armstrong, F.; Coppard, S. E.; Aguilera, F.; Bronstein, O.; Kroh, A.; Mooi, R.; Rouse, G. W.
10.1101/2021.07.19.453013 — evolutionary biology — Posted on 2021-07-24
961 Egress of human cytomegalovirus through multivesicular bodies
Flomm, F. J.; Soh, T. K.; Schneider, C.; Britt, H. M.; Thalassinos, K.; Pfitzner, S.; Reimer, R.; Gruenewald, K.; Bosse, J. B.
10.1101/2020.12.31.424954 — microbiology — Posted on 2021-07-24
963 An Integrated Workflow for Enhanced Taxonomic and Functional Coverage of the Mouse Faecal Metaproteome
Nalpas, N.; Hoyles, L.; Anselm, V.; Ganief, T.; Martinez-Gili, L.; Grau, C.; Droste-Borel, I.; Davidovic, L.; Altafaj, X.; Dumas, M.-E.; Macek, B.
10.1101/2020.11.17.386938 — microbiology — Posted on 2021-07-24
965 Eliminating accidental deviations to minimize generalization error and maximize replicability: applications in connectomics and genomics
Bridgeford, E. W.; Wang, S.; Yang, Z.; Wang, Z.; Xu, T.; Craddock, C.; Dey, J.; Kiar, G.; Gray-Roncal, W.; Coulantoni, C.; Douville, C.; Priebe, C. E.; Caffo, B.; Milham, M.; Zuo, X.-N.; Consortium for Reliability and Reproducibility, ; Vogelstein, J. T.
10.1101/802629 — neuroscience — Posted on 2021-07-24
969 DCIS genomic signatures define biology and correlate with clinical outcome: a Human Tumor Atlas Network (HTAN) analysis of TBCRC 038 and RAHBT cohorts
Strand, S. H.; Rivero-Gutierrez, B.; Houlahan, K. E.; Seoane, J. A.; King, L.; Risom, T.; Simpson, L. A.; Vennam, S.; Khan, A.; Cisneros, L.; Hardman, T.; Harmon, B.; Couch, F.; Gallagher, K.; Kilgore, M.; Wei, S.; DeMichele, A.; King, T.; McAuliffe, P. F.; Nangia, J.; Lee, J.; Tseng, J.; Storniolo, A. M.; Thompson, A.; Gupta, G.; Burns, R.; Veis, D. J.; DeSchryver, K.; Zhu, C.; Matusiak, M.; Wang, J.; Zhu, S. X.; Tappenden, J.; Ding, D. Y.; Zhang, D.; Luo, J.; Jiang, S.; Varma, S.; Anderson, L.; Straub, C.; Srivastava, S.; Curtis, C.; Tibshirani, R.; Angelo, R. M.; Hall, A.; Owzar, K.; Polyak
10.1101/2021.06.16.448585 — cancer biology — Posted on 2021-07-24
970 In vivo amyloid-like fibrils produced under stress
Fontana, N. A.; Rosse, A. D.; Watts, A.; Coelho, P. S. R.; Costa-Filho, A. J.
10.1101/2021.02.02.429251 — biophysics — Posted on 2021-07-24
973 Bayesian model comparison for rare variant association studies
Venkataraman, G. R.; DeBoever, C.; Tanigawa, Y.; Aguirre, M.; Ioannidis, A. G.; Mostafavi, H.; Spencer, C. C. A.; Poterba, T.; Bustamante, C. D.; Daly, M. J.; Pirinen, M.; Rivas, M. A.
10.1101/257162 — genetics — Posted on 2021-07-24
974 A comprehensive framework for handling location error in animal tracking data
Fleming, C. H.; Drescher-Lehman, J.; Noonan, M. J.; Akre, T. S. B.; Brown, D. J.; Cochrane, M. M.; Dejid, N.; DeNicola, V.; DePerno, C. S.; Dunlop, J. N.; Gould, N. P.; Harrison, A.-L.; Hollins, J.; Ishii, H.; Kaneko, Y.; Kays, R.; Killen, S. S.; Koeck, B.; Lambertucci, S. A.; LaPoint, S. D.; Medici, E. P.; Meyburg, B.-U.; Miller, T. A.; Moen, R. A.; Mueller, T.; Pfeiffer, T.; Pike, K. N.; Roulin, A.; Safi, K.; Sechaud, R.; Scharf, A. K.; Shephard, J. M.; Stabach, J. A.; Stein, K.; Tonra, C. M.; Yamazaki, K.; Fagan, W. F.; Calabrese, J. M.
10.1101/2020.06.12.130195 — ecology — Posted on 2021-07-24
980 Vision-based monitoring and measurement of bottlenose dolphins' daily habitat use and kinematics
Gabaldon, J.; Zhang, D.; Lauderdale, L.; Miller, L.; Johnson-Roberson, M.; Barton, K.; Shorter, K. A.
10.1101/2021.07.23.453543 — animal behavior and cognition — Posted on 2021-07-23
981 Deficiency in Lyst function leads to accumulation of secreted proteases and predisposition to mechanic stress-induced retinal detachment
Ji, X.; Zhao, L.; Umapathy, A.; Fitzmaurice, B.; Wang, J.; Williams, D. S.; Chang, B.; Naggert, J.; Nishina, P.
10.1101/2021.07.23.453557 — genetics — Posted on 2021-07-24
985 Identification of a distal RXFP1 gene enhancer with differential activity in fibrotic lung fibroblasts involving AP-1
Chen, T.-Y.; Li, X.; Goobie, G. C.; Hung, C.-H.; hamilton, H.; Bahudhanapati, H.; Tan, J.; Kass, D. J.; Zhang, Y.
10.1101/2021.07.23.453556 — molecular biology — Posted on 2021-07-23
987 {-}CardiOvascular examination in awake Orangutans (Pongo pygmaeus pygmaeus): Low-stress Echocardiography including Speckle Tracking imaging (the COOLEST method)
Chetboul, V.; Concordet, D.; Tissier, R.; Vonfeld, I.; Poissonnier, C.; Alvarado, M. P.; Passavin, P.; Gluntz, M.; Lefort, S.; Bourgeois, A.; Duby, D.; Hano, C.; Chai, N.
10.1101/2021.07.23.453539 — zoology — Posted on 2021-07-23
988 Nano-Insecticides Against the Black Cutworm Agrotis ipsilon (Lepidoptera: Noctuidae): Toxicity, Development, Enzyme activity, and DNA Mutagenicity
Awad, M. A. M.; Ibrahim, E.-D. S.; Osman, E. I.; Elmenofy, W. H.; Mahmoud, A. W. M.; Atia, M. A. M.; Moustafa, M. A. M.
10.1101/2021.07.23.453522 — zoology — Posted on 2021-07-23
990 Gastric cancer derived exosomes induce peritoneal mesothelial cell EMT through TGF-β1/Smads pathway to promote peritoneal metastasis
Dong, J.; Zhu, Z.; Cui, G.; Zhang, Z.; Yue, J.; Zhang, Y.; Yao, X.; Huo, M.; Wei, J.; Wang, Q.; Dai, L.; Li, P.; Liu, X.-P.
10.1101/2021.07.23.453534 — cancer biology — Posted on 2021-07-23
991 Performance of Deep Convolutional Neural Network Approaches and Human Level in Detecting Mosquito Species
Jomtarak, R.; Kittichai, V.; Pengsakul, T.; Phatthamolrat, N.; Naing, K. M.; Tongloy, T.; Chuwongin, S.; Boonsang, S.
10.1101/2021.07.23.453554 — bioinformatics — Posted on 2021-07-23
993 TELSAM polymers accelerate crystallization of fused target proteins by stabilizing minimal crystal contacts and in the absence of direct inter-TELSAM contacts
Sarath Nawarathnage, S. D.; Soleimani, S.; Mathis, M. H.; Bezzant, B. D.; Ramirez, D. T.; Gajjar, P.; Bunn, D.; Stewart, C.; Smith, T.; Pedroza-Romo, M. J.; Brown, S.; Doukov, T.; Moody, J. D.
10.1101/2021.07.23.453529 — biochemistry — Posted on 2021-07-23
994 Waves and currents decrease the available space in a salmon cage
Johannesen, A.; Patursson, O.; Kristmundsson, J.; Dam, S. P.; Mulelid, M.; Klebert, P.
10.1101/2021.07.23.453560 — animal behavior and cognition — Posted on 2021-07-23
996 Effects of pen enrichment on leg health of fast and slower-growing broiler chickens
Güz, B. C.; De Jong, I. C.; Souza Da Silva, C.; Veldkamp, F.; Kemp, B.; Molenaar, R.; van den Brand, H.
10.1101/2021.07.23.453550 — animal behavior and cognition — Posted on 2021-07-23
997 IDENTIFICATION OF HIGH SEED OIL YIELD AND HIGH OLEIC ACID CONTENT IN BRAZILIAN GERMPLASM OF WINTER SQUASH (Cucurbita moschata D.)
Gomes, R. S.; Machado Junior, R.; Almeida, C. F. d.; Oliveira, R. L. d.; Chagas, R. R.; Pereira, E. D.; Delazari, F. T.; Silva, D. J. H. d.
10.1101/2021.07.23.453548 — genetics — Posted on 2021-07-23
1001 Community health and human-animal contacts on the edges of Bwindi Impenetrable National Park, Uganda
Muylaert, R. L.; Davidson, B.; Ngabirano, A.; Kalema-Zikusoka, G.; MacGregor, H.; Lloyd-Smith, J. O.; Fayaz, A.; Knox, M.; Hayman, D. T. S.
10.1101/2021.07.23.453553 — ecology — Posted on 2021-07-23
1002 A real-time assay for cell-penetrating peptide-mediated delivery of molecular cargos
McMurry, J. L.; Gentry, S. B.; Nowak, S. J.; Ni, X.; Hill, S. A.; Wade, L. R.; Clark, W. R.; Keelaghan, A. P.; Morris, D. P.
10.1101/2021.07.23.453555 — cell biology — Posted on 2021-07-23
1003 Buenos Aires, June 2021Inhibition of Mitochondrial Fission by Drp-1 Blockade by Short-Term Leptin and Mdvi-1 Treatment Improves White Adipose Tissue Abnormalities in Obesity and Diabetes
Finocchietto, P.; Perez, H.; Blanco, G.; Miksztowicz, V.; Marotte, C.; Morales, C.; Peralta, J.; Berg, G.; Poderoso, C.; Poderoso, J. J.; Carreras, M. C.
10.1101/2021.07.23.453523 — molecular biology — Posted on 2021-07-23
1009 TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction
Khan, H.; Winstone, H.; Jimenez-Guardeno, J.; Graham, C.; Doores, K.; Goujon, C.; Matthews, D.; Davidson, A.; Rihn, S.; Palmarini, M.; Neil, S.; Malim, M.
10.1101/2021.07.23.453488 — microbiology — Posted on 2021-07-23
1010 Identification and Validation of N-Acetylputrescine in Combination With Non-Canonical Clinical Features As a Parkinsons Disease Biomarker Panel
Peng, K.-W.; Klotz, A.; Guven, A.; Kapadnis, U.; Ravipaty, S.; Tolstikov, V.; Vemulapalli, V.; Rodrigues, L. O.; Li, H.; Kellogg, M. D.; Kausar, F.; Rees, L.; Sarangarajan, R.; Schüle, B.; Langston, W.; Narain, P. P.; Narain, N. R.; Kiebish, M. A.
10.1101/2021.07.23.453542 — neuroscience — Posted on 2021-07-23
1014 Expression of Spred2 in the urothelial tumorigenesis of the urinary bladder
Oda, S.; Fujisawa, M.; Chunning, L.; Ito, T.; Yamaguchi, T.; Yoshimura, T.; Matsukawa, A.
10.1101/2021.07.23.453537 — pathology — Posted on 2021-07-23
1015 Effects of climatic change on the potential distribution of Lycoriella species (Diptera: Sciaridae) of economic importance
Marques, R.; Duarte, J. L.; Fonseca, A. d.; Krüger, R. F.; Silva, U.; Osorio-Olvera, L.; Contreras-Diaz, R. G.; Jimenez-Garcia, D.
10.1101/2021.07.23.453546 — bioinformatics — Posted on 2021-07-23
1017 Coordination of di-acetylated histone ligands by the ATAD2 bromodomain
Evans, C. M.; Phillips, M.; Malone, K. L.; Tonelli, M.; Cornilescu, G.; Cornilescu, C.; Holton, S.; Gorjanacz, M.; Wang, L.; Carlson, S.; Gay, J. C.; Nix, J. C.; Demeler, B.; Markley, J. L.; Glass, K. C.
10.1101/2021.07.23.453464 — biochemistry — Posted on 2021-07-23
1018 Characterization of BLUF-photoreceptors present in Acinetobacter nosocomialis.
Abatedaga, I.; Perez Mora, B.; Tuttobene, M.; Müller, G.; Biancotti, D.; Borsarelli, C. D.; Valle, L.; Mussi, M. A.
10.1101/2021.07.23.453528 — biochemistry — Posted on 2021-07-23
1025 Coordinated activation of both TGFβ and BMP canonical pathways regulates autophagy and tissue regeneration in acetaminophen induced liver injury
Stavropoulos, A.; Divolis, G.; Manioudaki, M.; Gavriil, A.; Kloukina, I.; Perrea, D. N.; Sountoulidis, A.; Ford, E.; Doulou, A.; Apostolidou, A.; Katsantoni, E.; Ritvos, O.; Germanidis, G.; Xilouri, M.; Sideras, P.
10.1101/2021.07.23.453185 — physiology — Posted on 2021-07-23
1026 Maternal microbiota Bifidobacterium promotes placental vascularization, nutrient transport and fetal growth in mice
Lopez-Tello, J.; Schofield, Z.; Kiu, R.; Dalby, M. J.; van Sinderen, D.; Le Gall, G.; Sferruzzi-Perri, A. N.; Hall, L. J.
10.1101/2021.07.23.453407 — physiology — Posted on 2021-07-23
1031 Using Deep Learning to Count Monarch Butterflies in Dense Clusters
Patel, S.; Kulkarni, A.; Mukhopadhyay, A.; Gujar, K.; Roode, J. d.
10.1101/2021.07.23.453502 — bioengineering — Posted on 2021-07-23
1032 Mitochondrial DNA variation across 56,434 individuals in gnomAD
Laricchia, K. M.; Lake, N. J.; Watts, N. A.; Shand, M.; Haessly, A.; Gauthier, L.; Benjamin, D.; Banks, E.; Soto, J.; Garimella, K.; Emery, J.; Genome Aggregation Database Consortium, ; Rehm, H. L.; MacArthur, D. G.; Tiao, G.; Lek, M. V.; Mootha, V. K.; Calvo, S. E.
10.1101/2021.07.23.453510 — genomics — Posted on 2021-07-23
1033 Nematode Small RNA Pathways in the Absence of piRNAs
Zagoskin, M.; Wang, J.; Neff, A. T.; Veronezi, G. M. B.; Davis, R. E.
10.1101/2021.07.23.453445 — genomics — Posted on 2021-07-23
1034 Selection of reference genes for quantitative analysis of microRNA expression in three cancers.
Veryaskina, Y.; Titov, S. E.; Ivanov, M. K.; Ruzankin, P. S.; Tarasenko, A. S.; Shevchenko, S. P.; Kovynev, I. B.; Stupak, E. V.; Pospelova, T. I.; Zhimulev, I. F.
10.1101/2021.07.23.453530 — genetics — Posted on 2021-07-23
1038 Microtubule-based mitotic spindles contain a micron-sized mixed-nucleotide zone
Castrogiovanni, C.; Inchingolo, A. V.; Harrison, J. U.; Dudka, D.; Sen, O.; Burroughs, N. J.; McAinsh, A. D.; Meraldi, P.
10.1101/2021.07.23.453504 — cell biology — Posted on 2021-07-23
1042 Probiotic consortia improve anti-viral immunity to SARS-CoV-2 in ferrets
Lehtinen, M.; Kumar, R.; Zabel, B.; Makela, S. M.; Nedveck, D.; Tang, P.; Latvala, S.; Guery, S.; Budinoff, C. R.
10.1101/2021.07.23.453521 — immunology — Posted on 2021-07-23
1043 Orphan cytochrome P450 20A1 CRISPR/Cas 9 mutants and neurobehavioral phenotypes in zebrafish
Brun, N. R.; Salanga, M. C.; Mora-Zamorano, F. X.; Lamb, D. C.; Goldstone, J. V.; Stegeman, J. J.
10.1101/2021.07.23.453406 — pharmacology and toxicology — Posted on 2021-07-23
1044 Intrinsically disordered N-terminal domain (NTD) of p53 interacts with mitochondrial PTP regulator Cyclophilin D
Zhao, J.; Liu, X.; Blayney, A.; Gandy, L.; Zhang, F.; Linhardt, R. J.; Zhang, Y.; Chen, J.; Baines, C.; Loh, S. N.; Wang, C.
10.1101/2021.07.23.453429 — biochemistry — Posted on 2021-07-23
1045 Mesalamine Reduces Intestinal ACE2 Expression Without Modifying SARS-CoV-2 Infection or Disease Severity in Mice.
Alvarado, D. M.; Son, J.; Thackray, L. B.; Diamond, M.; Ding, S.; Ciorba, M. A.; Washington University IBD Investigators Group,
10.1101/2021.07.23.453393 — microbiology — Posted on 2021-07-23
1046 The in vitro and in vivo potency of CT-P59 against Delta and its associated variants of SARS-CoV-2
Ryu, D.-K.; Woo, H.-M.; Kang, B.; Noh, H.; Kim, J.-I.; Seo, J.-M.; Kim, C.; Kim, M.; Kim, J.-W.; Kim, N.; Jeon, P.; Lee, H.; Yang, J.-S.; Kim, K.-C.; Lee, J.-Y.; Lee, M.-H.; Oh, S.-S.; Chung, H.-Y.; Kwon, K.-S.; Lee, S.-Y.
10.1101/2021.07.23.453472 — microbiology — Posted on 2021-07-23
1049 Novel Class of Psychedelic Iboga Alkaloids Disrupts Opioid Addiction States
Havel, V.; Kruegel, A. C.; Bechand, B.; McIntosh, S.; Stallings, L.; Hodges, A.; Wulf, M. G.; Nelson, M.; Hunkele, A.; Ansonoff, M.; Pintar, J. E.; Hwu, C.; Abi-Gerges, N.; Zaidi, S. A.; Katritch, V.; Yang, M.; Javitch, J. A.; Majumdar, S.; Hemby, S. E.; Sames, D.
10.1101/2021.07.22.453441 — pharmacology and toxicology — Posted on 2021-07-23
1050 How clustered protocadherin binding specificity is tuned for neuronal self/non-self-recognition
Goodman, K. M.; Katsamba, P. S.; Rubinstein, R.; Ahlsen, G.; Bahna, F.; Mannepalli, S.; Dan, H.; Sampogna, R.; Shapiro, L.; Honig, B.
10.1101/2021.07.22.453400 — biophysics — Posted on 2021-07-23
1051 Understanding the role of memory re-activation and cross-reactivity in the defense against SARS-CoV-2
Denninger, V.; Xu, C. K.; Meisl, G.; Morgunov, A. S.; Fiedler, S.; Ilsley, A.; Emmenegger, M.; Malik, A. Y.; Piziorska, M. A.; Schneider, M. M.; Devenish, S. R. A.; Kosmoliaptsis, V.; Aguzzi, A.; Fiegler, H.; Knowles, T. P. J.
10.1101/2021.07.23.453352 — biophysics — Posted on 2021-07-23
1053 A Highly Potent SARS-CoV-2 Blocking Lectin Protein
Ahan, R. E.; Hanifehnezhad, A.; Sahin Kehribar, E.; Oguzoglu, T. C.; Foldes, K.; Ozcelik, C. E.; Filazi, N.; Oztop, S.; Onder, S. C.; Bozkurt, E. U.; Ergunay, K.; Ozkul, A.; Seker, U.
10.1101/2021.07.22.453309 — biochemistry — Posted on 2021-07-23
1054 Faces of men with high serum testosterone are less attractive for women during the fertility phase of the menstrual cycle
Krejza, J.; Sledziewski, R.; Tabedzki, M.; Chen, R.; Krzystanek, E.; Arkuszewski, M.; Odachowska, M.; Kwiatkowska, K.; Marynowska, M.; Rogowski, M.; Ustymowicz, A.
10.1101/2021.07.22.453412 — evolutionary biology — Posted on 2021-07-23
1055 SARS-CoV-2 Exploits Sexually Dimorphic and Adaptive IFN and TNFa Signaling to Gain Entry into Alveolar Epithelium
Giancotti, F.; Wang, Y.; Gurrapu, S.; Chen, H.; Laudato, S.; Caggiano, E.; Jiang, Y.; Ling, H.-H.
10.1101/2021.07.23.453505 — immunology — Posted on 2021-07-23
1056 The precedence effect in spatial hearing emerges only late in the auditory pathway
Li, K.; Auksztulewicz, R.; Chan, C. H. K.; Mishra, A. P.; Schnupp, J. W. H.
10.1101/2021.07.21.453295 — neuroscience — Posted on 2021-07-23
1057 AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery
Potjewyd, F. M.; Annor-Gyamfi, J. K.; Aube, J.; Chu, S.; Conlon, I. L.; Frankowski, K. J.; Guduru, S. K. R.; Hardy, B. P.; Hopkins, M. D.; Kinoshita, C.; Kireev, D. B.; Mason, E. R.; Moerk, C. T.; Nwogbo, F.; Pearce, K. H.; Richardson, T.; Rogers, D. A.; Soni, D. M.; Stashko, M.; Wang, X.; Wells, C.; Willson, T. M.; Frye, S. V.; Young, J. E.; Axtman, A. D.
10.1101/2021.07.22.453404 — neuroscience — Posted on 2021-07-23
1059 Integrative proteomics and phosphoproteomics reveals phosphorylation networks involved in the maintenance and expression of embryogenic competence in sugarcane callus
Xavier, L. R.; Almeida, F. A.; Pinto, V. B.; Passamani, L. Z.; Santa-Catarina, C.; Filho, G. A. d. S.; Mooney, B. P.; Thelen, J. J.; Silveira, V.
10.1101/2021.07.22.453415 — plant biology — Posted on 2021-07-23
1061 A human ensemble cell atlas (hECA) enables in data cell sorting
Chen, S.; Luo, Y.; Gao, H.; Li, F.; Li, J.; Chen, Y.; You, R.; Hao, M.; Bian, H.; Xi, X.; Li, W.; Li, W.; Ye, M.; Meng, Q.; Zou, Z.; Li, C.; Li, H.; Zhang, Y.; Cui, Y.; Wei, L.; Chen, F.; Wang, X.; Lv, H.; Hua, K.; Jiang, R.; Zhang, X.
10.1101/2021.07.21.453289 — bioinformatics — Posted on 2021-07-23
1065 Copy number variations with adaptive potential in caribou (Rangifer tarandus): genome architecture and new annotated genome assembly
Prunier, J.; Carrier, A.; Gilbert, I.; Poisson, W.; Albert, V.; Taillon, J.; Bourret, V.; Cote, S. D.; Droit, A.; Robert, C.
10.1101/2021.07.22.453386 — genomics — Posted on 2021-07-23
1066 The interaction between a parasite and sub-optimal temperatures contributes to honey bee decline
Frizzera, D.; Andreuzza, L.; Boaro, G.; D'Agaro, M.; Del Fabbro, S.; Zanni, V.; Annoscia, D.; Nazzi, F.
10.1101/2021.07.22.453350 — ecology — Posted on 2021-07-23
1068 Baseline psychological traits contribute to Lake Louise Acute Mountain Sickness score at high altitude
Talks, B. J.; Campbell, C.; Larcombe, S. J.; Marlow, L.; Finnegan, S. L.; Lewis, C. T.; Lucas, S. J. E.; Harrison, O. K.; Pattinson, K. T. S.
10.1101/2021.07.22.451589 — neuroscience — Posted on 2021-07-23
1070 Not all smokers are alike: The hidden cost of sustained attention during nicotine abstinence
Deshpande, H. U.; Fedota, J. R.; Castillo, J.; Salmeron, B. J.; Ross, T. J.; Stein, E. A.
10.1101/2021.07.22.453142 — neuroscience — Posted on 2021-07-23
1071 Cerebral coherence in task-based fMRI hyperscanning: a new trick to an old dog
Wang, L.-S.; Cheng, J.-T.; Hsu, I.-J.; Liou, S.; Kung, C.-C.; Chen, D.-Y.; Weng, M.-H.
10.1101/2021.07.21.452832 — neuroscience — Posted on 2021-07-23
1073 Characterization of cocaine addiction-like behavior in heterogeneous stock rats
de Guglielmo, G.; Carrette, L.; Kallupi, M.; Brennan, M.; Boomhower, B.; Maturin, L.; Conlisk, D.; Sedighim, S.; Tieu, L.; Pavlich, M.; Martinez, A.; Velarde, N.; Kononoff, J.; Kimbrough, A.; Simpson, S.; Smith, L.; Shankar, K.; Krook, C.; Avelar, A.; Schweitzer, P.; Woods, L. S.; Palmer, A. A.; George, O.
10.1101/2021.07.22.453410 — neuroscience — Posted on 2021-07-23
1075 Proteome Profiling of Cerebrospinal Fluid Reveals Novel Biomarker Candidates for Parkinson's Disease
Karayel, O.; Virreira Winter, S.; Padmanabhan, S.; Kuras, Y. I.; Vu, D. T.; Tuncali, I.; Merchant, K.; Wills, A.-M.; Scherzer, C. R.; Mann, M.
10.1101/2021.07.22.453322 — systems biology — Posted on 2021-07-23
1076 THESEUS1 modulates cell wall stiffness and abscisic acid production in Arabidopsis thaliana
Bacete, L.; Schulz, J.; Engelsdorf, T.; Bartosova, Z.; Vaahtera, L.; Yan, G.; Gerhold, J.; Ticha, T.; Ovstebo, C.; Gigli-Bisceglia, N.; Starheim, S. J.; Margueritat, J.; Kollist, H.; Dehoux, T.; McAdam, S.; Hamann, T.
10.1101/2021.07.22.453418 — plant biology — Posted on 2021-07-23
1077 Pectin remodeling belongs to a homeostatic system and triggers transcriptomic and hormonal modulations
Jobert, F.; Guenin, S.; Voxeur, A.; Lee, K. J.; Bouton, S.; Senechal, F.; Hocq, L.; Mongelard, G.; Demailly, H.; Amakorova, P.; Strnad, M.; Vernhettes, S.; Mouille, G.; Pilard, S.; Knox, P.; Novak, O.; Pelloux, J.; Gutierrez, L.
10.1101/2021.07.22.453319 — plant biology — Posted on 2021-07-23
1078 Leptin protects against the development and expression of cocaine addiction-like behavior in heterogenous stock rats
Carrette, L. L. G.; Corral, C.; Crook, C.; Boomhower, B.; Brennan, M.; Ortez, C.; Shankar, K.; Simpson, S.; Maturin, L.; de Guglielmo, G.; Solberg-Woods, L.; Palmer, A. A.; George, O.
10.1101/2021.07.22.453426 — physiology — Posted on 2021-07-23
1083 A Workflow for Rapid Unbiased Quantification of Fibrillar Feature Alignment in Biological Images
Marcotti, S.; de Freitas, D. B.; Troughton, L. D.; Kenny, F. N.; Shaw, T. J.; stramer, b.; Oakes, P. W.
10.1101/2021.07.22.453401 — biophysics — Posted on 2021-07-23
1087 Non-specific adhesive forces between filaments and membraneless organelles
Böddeker, T. J.; Rosowski, K. A.; Berchtold, D.; Emmanouilidis, L.; Han, Y.; Allain, F. H. T.; Style, R. W.; Pelkmans, L.; Dufresne, E. R.
10.1101/2021.07.22.453380 — biophysics — Posted on 2021-07-23
1091 Polymer-Conjugated Carbon Nanotubes for Biomolecule Loading
Jackson, C. T.; Wang, J. W.; Gonzalez-Grandio, E.; Goh, N. S.; Mun, J.; Krishnan, S.; Landry, M. P.
10.1101/2021.07.22.453422 — biochemistry — Posted on 2021-07-23
1094 An ancestral burst of regulatory and protein innovation drives divergent implantation in eutherian mammals.
Taylor, A. S.; Tinning, H.; Ovchinnikov, V.; Smith, W.; Pullinger, A. L.; Sutton, R. A.; Constantinides, B.; Wang, D.; Forde, N.; O'Connell, M. J.
10.1101/2021.07.22.453388 — evolutionary biology — Posted on 2021-07-23
1095 Complement Regulator Factor H is a Cofactor for Thrombin in both Pro- and Anticoagulant Roles
McCluskey, G.; Davies, G. E.; Velounias, R. L.; Hughes, T. R.; Morgan, B. P.; Preston, R. J.; Collins, P. W.; Jenkins, P. V.; Heurich, M.
10.1101/2021.07.22.452893 — immunology — Posted on 2021-07-23
1097 Preconditioning by voluntary wheel running attenuates later neuropathic pain via Nrf2 antioxidant signaling in rats
Green-Fulgham, S. M.; Harland, M. E.; Ball, J. B.; D'Angelo, H.; Dreher, R. A.; Li, J.; Lacagnina, M. J.; Lorca, S. A.; Kwilasz, A. J.; Maier, S. F.; Watkins, L. R.; Grace, P. M.
10.1101/2021.07.21.452532 — neuroscience — Posted on 2021-07-23
1098 Drop, Swap, and Generate: A Self-Supervised Approach for Generating Neural Activity
Liu, R.; Azabou, M.; Dabagia, M.; Lin, C.-H.; Azar, M. G.; Hengen, K. B.; Valko, M.; Dyer, E. L.
10.1101/2021.07.21.453285 — neuroscience — Posted on 2021-07-23
1102 Prolonged Pain Reliably Slows Peak Alpha Frequency by Reducing Fast Alpha Power
Furman, A. J.; Prohorenko, M.; Keaser, M. L.; Zhang, J.; Chen, S.; Mazaheri, A.; Seminowicz, D. A.
10.1101/2021.07.22.453260 — neuroscience — Posted on 2021-07-23
1104 Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease
Assante, G.; Chandrasekaran, S.; Ng, S.; Tourna, A.; Chung, C. H.; Isse, K. A.; Filippi, C.; Dhawan, A.; Liu, M.; Rozen, S. G.; Hoare, M.; Campbell, P.; Ballard, J. W. O.; Turner, N.; Morris, M. J.; Chokshi, S.; Youngson, N. A.
10.1101/2021.07.22.453333 — cancer biology — Posted on 2021-07-23
1106 hafeZ: Active prophage identification through read mapping
Turkington, C. J. R.; Abadi, N. N.; Edwards, R. A.; Grasis, J. A.
10.1101/2021.07.21.453177 — bioinformatics — Posted on 2021-07-23
1108 Herbarium specimens reveal herbivory patterns across the genus Cucurbita
Jenny, L. A.; Shapiro, L. R.; Davis, C. C.; Davies, T. J.; Pierce, N. E.; Meineke, E.
10.1101/2021.07.21.452357 — ecology — Posted on 2021-07-23
1111 Cytolytic memory CD4+ T cell clonotypes are expanded during Plasmodium falciparum infection
Furtado, R.; Delahaye, F.; Zhang, J.; Sung, J.; Karell, P.; Kim, R. S.; Caillat-Zucman, S.; Liang, L.; Felgner, P.; Bauleni, A.; Gama, S.; Buchwald, A.; Taylor, T.; Seydel, K.; Laufer, M.; Daily, J.; Lauvau, G.
10.1101/2021.07.21.453277 — immunology — Posted on 2021-07-23
1112 Bassoon controls synaptic vesicle pools via regulation of presynaptic phosphorylation and cAMP homeostasis
Montenegro-Venegas, C.; Guhathakurta, D.; Pina-Fernandez, E.; Andres-Alonso, M.; Plattner, F.; Lazarevic, V.; Gundelfinger, E. D.; Fejtova, A.
10.1101/2021.07.22.453360 — neuroscience — Posted on 2021-07-23
1115 Deep embeddings to comprehend and visualize microbiome protein space
Odrzywolek, K.; Karwowska, Z.; Majta, J.; Byrski, A.; Milanowska-Zabel, K.; Kosciolek, T.
10.1101/2021.07.21.452490 — bioinformatics — Posted on 2021-07-23
1116 Intra-Articular Delivery of an Indoleamine 2,3-Dioxygenase Galectin-3 Fusion Protein for Osteoarthritis Treatment in Male Lewis Rats
Partain, B. D.; Bracho-Sanchez, E.; Farhadi, S. A.; Yarmola, E. G.; Keselowsky, B. G.; Hudalla, G. A.; Allen, K. D.
10.1101/2021.07.21.453247 — bioengineering — Posted on 2021-07-23
1118 The Amazon River microbiome, a story of humic carbon.
Sylvain, F.-E.; Bouslama, S.; Holland, A.; Leroux, N.; Mercier, P.-L.; Val, A. L.; Derome, N. J. A.
10.1101/2021.07.21.453257 — ecology — Posted on 2021-07-23
1119 Fast unconscious processing of emotional stimuli in early stages of the visual cortex
Carretie, L.; Fernandez-Folgueiras, U.; Alvarez, F.; Cipriani, G. A.; Tapia, M.; Kessel, D.
10.1101/2021.07.21.453248 — neuroscience — Posted on 2021-07-23
1121 Retrosplenial cortex is necessary for spatial and non-spatial latent learning in mice
Bottura de Barros, A. C.; Baruchin, L. J.; Panayi, M. C.; Nyberg, N.; Samborska, V.; Mealing, M. T.; Akam, T.; Kwag, J.; Bannerman, D. M.; Kohl, M. M.
10.1101/2021.07.21.453258 — neuroscience — Posted on 2021-07-23
1124 No evidence of human genome integration of SARS-CoV-2 found by long-read DNA sequencing
Smits, N.; Rasmussen, J.; Bodea, G. O.; Amarilla, A. A.; Gerdes, P.; Sanchez-Luque, F. J.; Ajjikuttira, P.; Modhiran, N.; Liang, B.; Faivre, J.; Deveson, I. W.; Khromykh, A. A.; Watterson, D.; Ewing, A. D.; Faulkner, G. J.
10.1101/2021.05.28.446065 — genomics — Posted on 2021-07-23
1130 Conserved exchange of paralog proteins during neuronal differentiation
Di Fraia, D.; Anitei, M.; Mackmull, M.-T.; Parca, L.; Behrendt, L.; Andres-Pons, A.; Gilmour, D.; Helmer-Citterich, M.; Kaether, C.; Beck, M.; Ori, A.
10.1101/2021.07.22.453347 — systems biology — Posted on 2021-07-23
1131 Capitalizing on paradoxical activation of the MAPK pathway for treatment of Imatinib-resistant mast cell leukemia and chronic myelogenous leukemia
Wilhelm, T.; Toledo, M. A.; Simons, I.; Stuth, C.; Mohta, V.; Mülfarth, R.; Nitsche, M.; Maschke-Neuss, K.; Schmitz, S.; Kaiser, A.; Arock, M.; Zenke, M.; Huber, M.
10.1101/2020.08.31.266734 — cancer biology — Posted on 2021-07-23
1134 Flight-induced compass representation in the monarch butterfly heading network
Beetz, M. J.; Kraus, C.; Franzke, M.; Dreyer, D.; Strube-Bloss, M.; Roessler, W.; Warrant, E. J.; Merlin, C.; el Jundi, B.
10.1101/2021.04.07.438824 — neuroscience — Posted on 2021-07-23
1135 Modelling spinal locomotor circuits for movements in developing zebrafish
Roussel, Y.; Gaudreau, S. F.; Kacer, E. R.; Sengupta, M.; Bui, T. V.
10.1101/2021.02.10.430671 — neuroscience — Posted on 2021-07-23
1138 Binding of DNA origami to lipids: maximising yield and switching via strand-displacement
Singh, J. K. D.; Darley, E.; Ridone, P.; Gaston, J. P.; Abbas, A.; Wickham, S. F.; Baker, M. A.
10.1101/2020.06.01.128686 — biophysics — Posted on 2021-07-23
1140 Bayesian model comparison for rare variant association studies
Venkataraman, G. R.; DeBoever, C.; Tanigawa, Y.; Aguirre, M.; Ioannidis, A. G.; Mostafavi, H.; Spencer, C. C. A.; Poterba, T.; Bustamante, C. D.; Daly, M. J.; Pirinen, M.; Rivas, M. A.
10.1101/257162 — genetics — Posted on 2021-07-23
1141 Fast transcriptional activation of developmental signalling pathways during wound healing of the calcareous sponge Sycon ciliatum
Caglar, C.; Ereskovsky, A.; Laplante, M.; Tokina, D.; Leininger, S.; Borisenko, I.; Aisbett, G.; Pan, D.; Adamski, M.; Adamska, M.
10.1101/2021.07.22.453456 — developmental biology — Posted on 2021-07-23
1146 Manipulation of RNA Polymerase III by Herpes Simplex Virus-1
Dremel, S. E.; Sivrich, F. L.; Tucker, J. M.; Glaunsinger, B. A.; DeLuca, N. A.
10.1101/2021.07.21.453214 — molecular biology — Posted on 2021-07-23
1147 Chronic release of tailless phage particles from Lactococcus lactis
Liu, Y.; Alexeeva, S.; Bachmann, H.; Guerra Martinez, J. A.; Yeremenko, N.; Abee, T.; Smid, E. J.
10.1101/2021.07.21.453303 — microbiology — Posted on 2021-07-23
1149 Prediction of fluorophore brightness in designed mini fluorescence activating proteins
Hostetter, E. R.; Keyes, J. R.; Poon, I.; Nguyen, J. P.; Nite, J.; Molecular Modeling and Design Class, ; Jimenez Hoyos, C. A.; Smith, C. A.
10.1101/2021.07.21.452510 — biophysics — Posted on 2021-07-23
1155 Inferring a spatial code of cell-cell interactions across a whole animal body
Armingol, E.; Ghaddar, A.; Joshi, C. J.; Baghdassarian, H.; Shamie, I.; Chan, J.; Her, H.-L.; O'Rourke, E. J.; Lewis, N. E.
10.1101/2020.11.22.392217 — bioinformatics — Posted on 2021-07-23
1156 Ablation of Proliferating Osteoblast Lineage Cells After Fracture Leads to Atrophic Nonunion in a Mouse Model
Hixon, K. R.; McKenzie, J. A.; Sykes, D. A.; Yoneda, S.; Hensley, A.; Buettmann, E. G.; Zheng, H.; Skouteris, D.; McAlinden, A.; Miller, A. N.; Silva, M. J.
10.1101/2020.10.06.327288 — bioengineering — Posted on 2021-07-22
1158 The anterior Hox gene ceh-13 and elt-1/GATA activate the posterior Hox genes nob-1 and php-3 to specify posterior lineages in the C. elegans embryo
Murray, J. I.; Preston, E.; Crawford, J. P.; Rumley, J. D.; Amom, P.; Anderson, B. D.; Sivaramakrishnan, P.; Patel, S. D.; Bennett, B. A.; Lavon, T. D.; Peng, F.; Zacharias, A. L.
10.1101/2021.02.09.430385 — genetics — Posted on 2021-07-23
1159 Force generation of KIF1C is impaired by pathogenic mutations
Siddiqui, N.; Roth, D.; Toleikis, A.; Zwetsloot, A. J.; Cross, R. A.; Straube, A.
10.1101/2021.06.30.450611 — cell biology — Posted on 2021-07-23
1170 GIV/Girdin binds BRCA1 and links trimeric G-proteins to DNA damage response
Abd El-Hafeez, A. A.; Sun, N.; Chakraborty, A.; Ear, J.; Roy, S.; Chamarthi, P.; Rajapakse, N.; Das, S.; Luker, K. E.; Hazra, T. K.; Luker, G. D.; Ghosh, P.
10.1101/2021.07.21.452842 — cancer biology — Posted on 2021-07-22
1171 Perturbation of BRMS1 interactome reveals pathways that impact cell migration
Zimmermann, R. C.; Sardiu, M. E.; Manton, C. A.; Miah, M. S.; Banks, C. A.; Adams, M. K.; Koestler, D. C.; Hurst, D. R.; Edmonds, M. D.; Washburn, M. P.; Welch, D. R.
10.1101/2021.02.04.429764 — cancer biology — Posted on 2021-07-22
1172 Genomic context sensitivity of insulator function
Ribeiro-dos-Santos, A. M.; Hogan, M. S.; Luther, R.; Maurano, M. T.
10.1101/2021.05.16.444030 — genomics — Posted on 2021-07-22
1173 Transcription factor regulation of eQTL activity across individuals and tissues
Flynn, E.; Tsu, A. L.; Kasela, S.; Kim-Hellmuth, S.; Aguet, F.; Ardlie, K. G.; Bussemaker, H. J.; Mohammadi, P.; Lappalainen, T.
10.1101/2021.07.20.453075 — genomics — Posted on 2021-07-22
1177 MERTK on mononuclear phagocytes regulates T cell antigen recognition at autoimmune and tumor sites
Lindsay, R. S.; Whitesell, J. C.; Dew, K. E.; Rodriguez, E.; Sandor, A. M.; Tracy, D.; Yannacone, S. F.; Basta, B. N.; Jacobelli, J.; Friedman, R. S.
10.1101/687061 — immunology — Posted on 2021-07-22
1178 Forearm and hand muscles exhibit high coactivation and overlapping of cortical motor representations
Pazin Tardelli, G.; Souza, V. H.; Hiroshi Matsuda, R.; Cavalcanti Garcia, M. A.; Novikov, P.; Nazarova, M.; Baffa, O.
10.1101/2021.07.20.453121 — neuroscience — Posted on 2021-07-22
1180 GABAA and NMDA receptor density alterations and their behavioral correlates in the gestational methylazoxymethanol acetate model for schizophrenia
Kiemes, A.; Gomes, F. V.; Cash, D.; Uliana, D. L.; Simmons, C.; Singh, N.; Vernon, A. C.; Turkheimer, F. E.; Davies, C.; Stone, J. M.; Grace, A. A.; Modinos, G.
10.1101/2021.06.21.449343 — neuroscience — Posted on 2021-07-22
1181 Metabolic-sensing in AgRP neurons integrates homeostatic state with dopamine signalling in the striatum
Reichenbach, A.; Clarke, R.; Stark, R.; Lockie, S. H.; Mequinion, M.; Reed, F.; Rawlinson, S.; Dempsey, H.; Sepehrizadeh, T.; DeVeer, M.; Munder, A. C.; Nunez-Iglesias, J.; Spanswick, D. C.; Mynatt, R.; Kravitz, L.; Dayas, C. V.; Brown, R.; Andrews, Z. B.
10.1101/2021.03.22.436393 — neuroscience — Posted on 2021-07-22
1182 Image-based assessment of plant disease progression identifies new genetic loci for resistance
Meline, V.; Caldwell, D.; Kim, B.-S. S.; Baireddy, S.; Yang, C.; Sparks, E. E.; Delp, E. J.; Iyer-Pascuzzi, A. S.
10.1101/2021.07.13.452064 — plant biology — Posted on 2021-07-22
1187 Electronic "photoreceptors" enable prosthetic vision with acuity matching the natural resolution in rats
Wang, B.-Y.; Chen, Z. C.; Bhuckory, M.; Huang, T. W.; Shin, A.; Zuckerman, V.; Ho, E.; Rosenfeld, E.; Galambos, L.; Kamins, T.; Mathieson, K.; Palanker, D.
10.1101/2021.07.12.452093 — bioengineering — Posted on 2021-07-22
1188 A stable pollination environment limits current but not potential evolution of floral traits
Castellanos, M. C.; Montero-Pau, J.; Ziarsolo, P.; Blanca, J. M.; Canizares, J.; Pausas, J. G.
10.1101/581827 — evolutionary biology — Posted on 2021-07-22
1193 Restructuring of genomic provinces of surface ocean plankton under climate change
Fremont, P.; Gehlen, M.; Vrac, M.; Leconte, J.; Delmont, T.; Wincker, P.; Iudicone, D.; Jaillon, O.
10.1101/2020.10.20.347237 — ecology — Posted on 2021-07-22
1194 Histone acetyltransferase activity of CREB-binding protein is essential for synaptic plasticity in Lymnaea
Hatakeyama, D.; Sunada, H.; Totani, Y.; Watanabe, T.; Felletar, I.; Fitchett, A.; Eravci, M.; Anagnostopoulou, A.; Miki, R.; Kuzuhara, T.; Kemenes, I.; Ito, E.; Kemenes, G.
10.1101/2021.05.26.445902 — neuroscience — Posted on 2021-07-22
1195 Structure and lipid-mediated remodelling mechanism of the Na+/H+ exchanger NHA2
Matsuoka, R.; Fudim, R.; Jung, S.; Zhang, C.; Bazzone, A.; Chatzikyriakidou, Y.; Nomura, N.; Iwata, S.; Orellana, L.; Beckstein, O.; Drew, D.
10.1101/2021.07.22.453398 — biophysics — Posted on 2021-07-22
1197 Limited accessibility of nitrogen supplied as amino acids, amides, and amines as energy sources for marine Thaumarchaeota
Damashek, J.; Bayer, B.; Herndl, G. J.; Wallsgrove, N. J.; Allen, T.; Popp, B. N.; Hollibaugh, J. T.
10.1101/2021.07.22.453390 — microbiology — Posted on 2021-07-22
1198 Cryo-EM structure of the NLRP3 decamer bound to the cytokine release inhibitory drug CRID3
Hochheiser, I. V.; Pilsl, M.; Hagelueken, G.; Moecking, J.; Marleaux, M.; Brinkschulte, R.; Latz, E.; Engel, C.; Geyer, M.
10.1101/2021.07.22.453353 — immunology — Posted on 2021-07-22
1199 Transcriptional regulatory features associated with Coccidioides immitis phase transition
Duttke, S. H.; Beyhan, S.; Singh, R.; Neal, S. E.; Viriyakosol, S.; Fierer, J.; Kirkland, T. N.; Stajich, J. E.; Benner, C.; Carlin, A.
10.1101/2021.07.22.453417 — immunology — Posted on 2021-07-22
1202 Gestational insulin resistance is mediated by the gut microbiome-indoleamine 2,3-dioxygenase axis
Priyadarshini, M.; Navarro, G.; Reiman, D.; Sharma, A.; Xu, K.; Lednovich, K.; Manzella, C. R.; Khan, M. W.; Wicksteed, B.; Chlipala, G. E.; Szynal, B.; Bernabe, B. P.; Maki, P. M.; Gill, R. K.; Gilbert, J.; Dai, Y.; Layden, B. T.
10.1101/2021.07.21.453234 — physiology — Posted on 2021-07-22
1203 GIV/Girdin binds BRCA1 and links trimeric G-proteins to DNA damage response
Abd El-Hafeez, A. A.; Sun, N.; Chakraborty, A.; Ear, J.; Roy, S.; Chamarthi, P.; Rajapakse, N.; Das, S.; Luker, K. E.; Hazra, T. K.; Luker, G. D.; Ghosh, P.
10.1101/2021.07.21.452842 — cancer biology — Posted on 2021-07-22
1205 GM1 mediates the formation and maintenance of cytotoxic Aβ oligomers
Zhang, D.; Wang, J.; Fleeman, R. M.; Kuhn, M. K.; Swulius, M. T.; Proctor, E. A.; Dokholyan, N. V.
10.1101/2021.07.22.453392 — biophysics — Posted on 2021-07-22
1207 E-cadherin regulates the stability and transcriptional activity of β-catenin in embryonic stem cells
Bhattacharyya, S.; Mote, R. D.; Freimer, J.; Singh, S. B.; Arumugam, S.; Narayana, Y. V.; Rajan, R.; Subramanyam, D.
10.1101/2021.07.22.453344 — cell biology — Posted on 2021-07-22
1208 Systematic mapping of small nucleolar RNA targets in human cells
Dunn-Davies, H.; Dudnakova, T.; Langhendries, J.-L.; Watkins, N.; Lafontaine, D. L.; Tollervey, D.
10.1101/2021.07.22.451324 — cell biology — Posted on 2021-07-22
1212 RTT109 AND Fun30 proteins mediate epigenetic regulation of the DNA damage response pathway in C. albicans
Maurya, P. K.; Garai, P.; Goel, K.; Bhatt, H.; Goyal, A.; Dewasthale, S.; Gupta, M.; Dutta, A.; Haokip, D. T.; Barik, S.; Muthuswami, R.
10.1101/2021.07.22.453354 — molecular biology — Posted on 2021-07-22
1213 Quantification of archaea-driven freshwater nitrification: from single cell to ecosystem level
Klotz, F.; Kitzinger, K.; Ngugi, D. K.; Buesing, P.; Littmann, S.; Kuypers, M. M. M.; Schink, B.; Pester, M.
10.1101/2021.07.22.453385 — microbiology — Posted on 2021-07-22
1214 Roles of proteins containing immunoglobulin-like domains in the conjugation of bacterial plasmids.
Huttener, M.; Hergueta, J.; Bernabeu, M.; Prieto, A.; Aznar, S.; Merino, S.; Tomas, J.; Juarez, A.
10.1101/2021.07.22.453378 — microbiology — Posted on 2021-07-22
1215 The Murine Neuronal Receptor NgR1 Is Dispensable for Reovirus Pathogenesis
Aravamudhan, P.; Guzman-Cardozo, C.; Urbanek, K.; Welsh, O.; Konopka-Anstadt, J.; Sutherland, D. M.; Dermody, T. S.
10.1101/2021.07.22.453368 — microbiology — Posted on 2021-07-22
1216 Gammaherpesvirus infection licenses age-associated B cells for pathogenicity in MS and EAE
Mouat, I. C.; Allanach, J. R.; Fan, V.; Girard, A. M.; Shanina, I.; Vorobeychik, G.; Horwitz, M. S.
10.1101/2021.07.22.453263 — immunology — Posted on 2021-07-22
1219 Proton-mediated gating mechanism of anion channelrhodopsin-1
Tsujimura, M.; Kojima, K.; Kawanishi, S.; Sudo, Y.; Ishikita, H.
10.1101/2021.07.22.453395 — biochemistry — Posted on 2021-07-22
1221 Dichloroacetate improves systemic energy balance and feeding behavior during sepsis
Oh, T.; Zabalawi, M.; Jain, S.; Long, D.; Stacpoole, P.; McCall, C.; Quinn, M. A.
10.1101/2021.07.21.453238 — immunology — Posted on 2021-07-22
1222 CD8+ T cell signature in acute SARS-CoV-2 infection identifies memory precursors
Adamo, S.; Michler, J.; Zurbuchen, Y.; Cervia, C.; Taeschler, P.; Raeber, M. E.; Baghai Sain, S.; Nilsson, J.; Moor, A.; Boyman, O.
10.1101/2021.07.22.453029 — immunology — Posted on 2021-07-22
1223 Abnormal Recovery from Acute Stress in Huntingtons Disease Mice
Zacharoff, L. A.; Hamid, A. A.; Engeland, W. C.; Dubinsky, J. M.
10.1101/2021.07.21.453245 — neuroscience — Posted on 2021-07-22
1225 Automated imaging of duckweed growth and development
Cox, K. L.; Manchego, J.; Meyers, B. C.; Czymmek, K. J.; Harkess, A.
10.1101/2021.07.21.453240 — plant biology — Posted on 2021-07-22
1226 NetSolP: predicting protein solubility in E. coli using language models
Thumuluri, V.; Martiny, H.-M.; Armenteros, J. J. A.; Salomon, J.; Nielsen, H.; Johansen, A.
10.1101/2021.07.21.453084 — bioinformatics — Posted on 2021-07-22
1228 Competent immune responses to SARS-CoV-2 variants in older adults following mRNA vaccination
Jergovic, M.; Uhrlaub, J. L.; Watanabe, M.; Bradshaw, C. M.; White, L. M.; LaFleur, B. J.; Edwards, T.; Sprissler, R.; Worobey, M.; Bhattacharya, D.; Nikolich-Zugich, J.
10.1101/2021.07.22.453287 — immunology — Posted on 2021-07-22
1231 Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer
Memon, D.; Rizvi, H.; Fromm, G.; Lihm, J.; Schoenfeld, A. J.; Sauter, J. L.; Luo, J.; Chow, A.; Bhanot, U. K.; McCarthy, C.; Ye, D.; Vanderbilt, C. M.; Liu, C.; Abu-Akeel, M.; Plodkowski, A. J.; McGranahan, N.; Luksza, M.; Greenbaum, B. D.; Merghoub, T.; Minn, A. J.; Beltrao, P.; Schreiber, T. H.; Miller, M. L.; Hellmann, M. D.
10.1101/2021.07.21.452854 — cancer biology — Posted on 2021-07-22
1232 Structure insights, thermodynamic profiles, dsDNA melting activity, and liquid-liquid phase separation of the SARS-CoV-2 nucleocapsid N-terminal domain binding to DNA
Caruso, I. P.; Almeida, V. S.; Amaral, M. J.; Andrade, G. C.; Araujo, G. R.; Araujo, T. S.; Azevedo, J. M.; Barbosa, G. M.; Bartkevihi, L.; Bezerra, P. R.; Cabral, K. M. d. S.; Lourenco, I. O.; Malizia-Motta, C. L. F.; Marques, A. L.; Mebus-Antunes, N. C.; Neves-Martins, T. C.; de Sa, J. M.; Sanches, K.; Santana-Silva, M. C.; Vasconcelos, A. A.; Almeida, M. S.; Amorim, G. C.; Anobom, C. D.; Da Poian, A. T.; Gomes-Neto, F.; Pinheiro, A. S.; Almeida, F. C. L.
10.1101/2021.07.21.453232 — biophysics — Posted on 2021-07-22
1233 Evolutionary tuning of a key helix drove androgen selectivity
Okafor, C. D.; Colucci, J. K.; Cato, M. L.; Khan, S. H.; Cottrill, K.; Hercules, D.; Eick, G.; Thornton, J. W.; Ortlund, E. A.
10.1101/2021.07.21.453223 — evolutionary biology — Posted on 2021-07-22
1235 Neuroprotective, antioxidant and antiproliferative activity of grapefruit IntegroPectin on SH-SY5Y cells
Nuzzo, D.; Scodino, M.; Scurria, A.; Giardina, C.; Giordano, F.; Meneguzzo, F.; Mudo, G.; Pagliaro, M.; Picone, P.; Attanzio, A.; Raimondo, S.; Ciriminna, R.; Di Liberto, V.
10.1101/2021.07.21.453202 — neuroscience — Posted on 2021-07-22
1236 The five Urochola spp. used in development of tropical forage cultivars originate from defined subpopulations with differentiated gene pools
Higgins, J.; Tomaszewska, P.; Pellny, T. K.; Castiblanco, V.; Arango, J.; Tohme, J.; Schwarzacher, T.; Mitchell, R.; Heslop-Harrison, J. S.; De Vega, J. J.
10.1101/2021.07.21.453213 — plant biology — Posted on 2021-07-22
1237 Kinome state is predictive of cell viability in pancreatic cancer tumor and stroma cell lines
Berginski, M. E.; Jenner, M. R.; Joisa, C. U.; Herrera Loeza, S. G.; Golitz, B. T.; Lipner, M. B.; Leary, J. R.; Rashid, N. U.; Johnson, G. L.; Yeh, J. J.; Gomez, S. M.
10.1101/2021.07.21.451515 — bioinformatics — Posted on 2021-07-22
1239 skater: An R package for SNP-based Kinship Analysis, Testing, and Evaluation
Turner, S. D.; Nagraj, V. P.; Scholz, M.; Jessa, S.; Acevedo, C.; Ge, J.; Woerner, A. E.; Budowle, B.
10.1101/2021.07.21.453083 — bioinformatics — Posted on 2021-07-22
1240 Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes
Schunkert, H.; Li, L.; Chen, Z.; Scheidt, M. v.; Steiner, A.; Gueldener, U.; Koplev, S.; Ma, A.; Hao, K.; Pan, C.; Lusis, A. J.; Pang, S.; Kessler, T.; Ermel, R.; Sukhavasi, K.; Ruusalepp, A.; Gagneur, J.; Erdmann, J.; Kovacic, J. C.; Bjoerkegren, J. L. M.
10.1101/2021.07.21.453208 — genetics — Posted on 2021-07-22
1242 Lowland plant migrations into alpine ecosystems amplify soil carbon loss under climate warming
Walker, T. W. N.; Gavazov, K.; Guillaume, T.; Lambert, T.; Mariotte, P.; Routh, D.; Signarbieux, C.; Block, S.; Muenkemueller, T.; Nomoto, H.; Crowther, T. W.; Richter, A.; Buttler, A.; Alexander, J. M.
10.1101/2021.07.21.453211 — ecology — Posted on 2021-07-22
1246 Impact of human airway epithelial cellular composition on SARS-CoV-2 infection biology
Wang, Y.; Thaler, M.; Ninaber, D.; van der Does, A. M.; S. Ogando, N. S.; Beckert, H.; Taube, C.; Salgado Benvindo Da Silva, C.; Snijder, E. J.; Bredenbeek, P. J.; Hiemstra, P.; van Hemert, M. J.
10.1101/2021.07.21.453304 — cell biology — Posted on 2021-07-22
1247 Conserved Circuits for Direction Selectivity in the Primate Retina
Patterson, S. S.; Bembry, B. N.; Mazzaferri, M. A.; Neitz, M.; Rieke, F.; Soetedjo, R.; Neitz, J.
10.1101/2021.07.21.453225 — neuroscience — Posted on 2021-07-22
1252 Contribution of genome scale metabolic modeling to niche theory
Regimbeau, A.; Budinich, M.; Larhlimi, A.; Pierella Karlusich, J. J.; Aumont, O.; Memery, L.; Bowler, C.; Eveillard, D.
10.1101/2021.07.21.453190 — ecology — Posted on 2021-07-22
1253 Hypoxia induces a transcriptional early primitive streak signature in pluripotent cells enhancing spontaneous elongation and lineage representation in gastruloids
Lopez-Anguita, N.; Gassaloglu, S. I.; Stötzel, M.; Typou, M.; Virta, I.; Hetzel, S.; Buschow, R.; Koksal, B.; Atilla, D.; Maitschke-Rajasekharan, R.; Chen, R.; Mattei, A. L.; Bedzhov, I.; Meierhofer, D.; Meissner, A.; Veenvliet, J. V.; Bulut-Karslioglu, A.
10.1101/2021.07.21.452906 — developmental biology — Posted on 2021-07-22
1256 Egg size variation in a long-lived polyandrous shorebird in the context of senescence and breeding phenology
Eberhart-Hertel, L. J.; Falcao Rodrigues, L.; Krietsch, J.; Eberhart-Hertel, A. G.; Cruz-Lopez, M.; Vazquez-Rojas, K. A.; Gonzalez-Medina, E.; Schroeder, J.; Kuepper, C.
10.1101/2021.07.21.453188 — evolutionary biology — Posted on 2021-07-22
1259 TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling
Sivakumar, S.; Qi, S.; Cheng, N.; sathe, A. a.; Kanchwala, M.; Kumar, A.; Evers, B. M.; Xing, C.; Yu, H.
10.1101/2021.07.22.453348 — developmental biology — Posted on 2021-07-22
1260 Evolutionary conservation of centriole rotational asymmetry in the human centrosome
GAUDIN, N.; MARTIN GIL, P.; BOUMENDJEL, M.; ERSHOV, D.; PIOCHE-DURIEU, C.; BOUIX, M.; DELOBELLE, Q.; MANISCALCO, L.; PHAN, T. B. N.; HEYER, V.; REINA-SAN-MARTIN, B.; AZIMZADEH, J.
10.1101/2021.07.21.453218 — cell biology — Posted on 2021-07-22
1261 Developmental landscape of human forebrain at a single-cell level unveils early waves of oligodendrogenesis
van Bruggen, D.; Pohl, F. B.; Mattsson Langseth, C.; Kukanja, P.; Lee, H.; Kabbe, M.; Meijer, M.; Hilscher, M.; Nilsson, M.; Sundstrom, E.; Castelo-Branco, G.
10.1101/2021.07.22.453317 — neuroscience — Posted on 2021-07-22
1264 High potency of sequential therapy with only beta-lactam antibiotics
Batra, A.; Roemhild, R.; Rousseau, E.; Franzenburg, S.; Niemann, S.; Schulenburg, H.
10.1101/2021.07.20.453050 — evolutionary biology — Posted on 2021-07-22
1267 Bayesian inference of population prevalence
Ince, R. A. A.; Paton, A. T.; Kay, J. W.; Schyns, P. G.
10.1101/2020.07.08.191106 — neuroscience — Posted on 2021-07-22
1273 Modelling the spatiotemporal spread of beneficial alleles using ancient genomes
Muktupavela, R. A.; Petr, M.; Ségurel, L.; Korneliussen, T. S.; Novembre, J.; Racimo, F.
10.1101/2021.07.21.453231 — evolutionary biology — Posted on 2021-07-22
1275 Defining the prototypical DNA replication fork trap in bacteria
Toft, C.; Moreau, M.; Perutka, J.; Mandapati, S.; Enyeart, P.; Sorenson, A.; Ellington, A.; Schaeffer, P. M.
10.1101/2021.07.20.453168 — molecular biology — Posted on 2021-07-22
1277 Impaired developmental microglial pruning of excitatory synapses on CRH-expressing hypothalamic neurons exacerbates stress responses throughout life
Bolton, J. L.; Short, A. K.; Othy, S.; Kooiker, C. L.; Shao, M.; Gunn, B. G.; Beck, J.; Bai, X.; Law, S. M.; Savage, J. C.; Lambert, J. J.; Belelli, D.; Tremblay, M.-E.; Cahalan, M. D.; Baram, T. Z.
10.1101/2021.07.21.453252 — neuroscience — Posted on 2021-07-22
1287 Efficient inhibition of HIV using CRISPR/Cas13d nuclease system
Nguyen, H.; Wilson, H.; Jayakumar, S.; Kulkarni, V.; Kulkarni, S.
10.1101/2021.07.21.453273 — molecular biology — Posted on 2021-07-21
1293 Gram-positive bacteria secrete RNA aptamers to activate human STING for IL-1β release.
Duduskar, S. N.; Ghait, M.; Westermann, M.; Guo, H.; Ramoji, A.; Sponholz, C.; Goehrig, B.; Bruns, T.; Neugebauer, U.; Popp, J.; Tuchscherr, L. P. N.; Loeffler, B.; Ueberschaar, N.; Beemelmanns, C.; Singer, M.; Bauer, M.; Deshmukh, S. D.
10.1101/2021.07.21.453173 — immunology — Posted on 2021-07-21
1295 Analysis of genotype by environment interactions in a maize mapping population
Hudson, A. I.; Odell, S. G.; Dubreuil, P.; Tixier, M.-H.; Praud, S.; Runcie, D. E.; Ross-Ibarra, J.
10.1101/2021.07.21.453280 — plant biology — Posted on 2021-07-21
1298 A pair of transporters controls mitochondrial Zn2+ levels to maintain mitochondrial homeostasis
Ma, T.; Zhao, L.; Zhang, J.; Tang, R.; Wang, X.; Liu, N.; Zhang, Q.; Wang, F.; Li, M.; Shan, Q.; Yang, Y.; Yin, Q.; Yang, L.; Gan, Q.; Yang, C.
10.1101/2021.07.21.453180 — cell biology — Posted on 2021-07-21
1299 Two redundant ubiquitin-dependent pathways of BRCA1 localization to DNA damage sites
Sherker, A.; Chaudhary, N.; Adam, S.; Noordermeer, S. M.; Fradet-Turcotte, A.; Durocher, D.
10.1101/2021.07.21.452958 — molecular biology — Posted on 2021-07-21
1300 Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice
Gul, S.; Akyel, Y. K.; Gul, Z. M.; Isin, S.; Korkmaz, T.; Selvi, S.; Danis, I.; Ipek, O. S.; Aygenli, F.; Taskin, A. C.; Ozturk, N.; Ozturk, N.; Ozer Unal, D.; Guzel, M.; Turkay, M.; Okyar, A.; Kavakli, I. H.
10.1101/2021.07.21.453206 — molecular biology — Posted on 2021-07-21
1301 Unlike Chloroquine, mefloquine inhibits SARS-CoV-2 infection in physiologically relevant cells and does not induce viral variants.
Sacramento, C. Q.; Fintelman-Rodrigues, N.; Dias, S. S. G.; Temerozo, J. R.; Da Silva, A. d. P. D.; da Silva, C. S.; Ferreira, A. C.; Mattos, M.; Soares, V. C.; Pereira-Dutra, F.; Miranda, M. D.; Barreto-Vieira, D. F.; da Silva, M. A. N.; de Siqueira Santos, S.; Torres, M.; Rajoli, R. K. R.; Paccanaro, A.; Owen, A.; Bou-Habib, D. C.; Bozza, P. T.; Souza, T. M. L.
10.1101/2021.07.21.451321 — microbiology — Posted on 2021-07-21
1305 Toxoplasma gondii subverts the host ESCRT machinery for parasite uptake of host cytosolic proteins
Rivera-Cuevas, Y.; Mayoral, J.; Di Cristina, M.; Lawrence, A.-L. E.; Olafsson, E. B.; Thornhill, D.; Waldman, B. S.; Ono, A.; Sexton, J.; Lourido, S.; Weiss, L. M.; Carruthers, V. B.
10.1101/2021.07.21.453261 — microbiology — Posted on 2021-07-21
1307 Single Cell Variability of CRISPR-Cas Interference and Adaptation
McKenzie, R. E.; Keizer, E. M.; Vink, J. N. A.; van Lopik, J.; Büke, F.; Kalkman, V.; Fleck, C.; Tans, S. J.; Brouns, S. J. J.
10.1101/2021.07.21.453200 — microbiology — Posted on 2021-07-21
1308 Maturation, developmental site, and pathology dictate murine neutrophil function
Mackey, J. B. G.; McFarlane, A. J.; Jamieson, T.; Jackstadt, R.; Raffo-Iraolagoitia, X. L.; Secklehner, J.; Cortes-Lavaud, X.; Fercoq, F.; Clarke, W.; Hedley, A.; Gilroy, K.; Lilla, S.; Vuononvirta, J.; Graham, G. J.; De Filippo, K.; Murphy, D. J.; Steele, C. W.; Norman, J. C.; Bird, T. G.; Mann, D. A.; Morton, J. P.; Zanivan, S.; Sansom, O. J.; Carlin, L. M.
10.1101/2021.07.21.453108 — immunology — Posted on 2021-07-21
1309 The RNA m6A binding protein YTHDF2 promotes the B cell to plasma cell transition.
Turner, D.; Saveliev, A.; Salerno, F.; Matheson, L. S.; Screen, M.; Lawson, H.; Wotherspoon, D.; Kranc, K.; Turner, M.
10.1101/2021.07.21.453193 — immunology — Posted on 2021-07-21
1311 Combination of Antiviral Drugs to Inhibit SARS-CoV-2 Polymerase and Exonuclease as Potential COVID-19 Therapeutics
Wang, X.; Sacramento, C. Q.; Jockusch, S.; Chaves, O. A.; Tao, C.; Fintelman-Rodrigues, N.; Chien, M.; Temerozo, J. R.; Li, X.; Kumar, S.; Xie, W.; Patel, D. J.; Meyer, C.; Garzia, A.; Tuschl, T.; Bozza, P. T.; Russo, J. J.; Souza, T. M. L.; Ju, J.
10.1101/2021.07.21.453274 — pharmacology and toxicology — Posted on 2021-07-21
1316 Degradation of Red Blood Cell Deformability during Cold Storage in Blood Bags
Islamzada, E.; Matthews, K.; Lamoureux, E.; Duffy, S. P.; Scott, M. D.; Ma, H.
10.1101/2021.07.20.452409 — bioengineering — Posted on 2021-07-21
1318 The interplay of additivity, dominance, and epistasis in a diploid yeast cross
Matsui, T.; Mullis, M.; Roy, K.; Hale, J.; Schell, R.; Levy, S. F.; Ehrenreich, I.
10.1101/2021.07.20.453124 — genetics — Posted on 2021-07-21
1320 CFTR modulator response measurements in subjects with cystic fibrosis using 2D differentiated nasal epithelia converted into spheroids
Amatngalim, G. D.; Rodenburg, L. W.; Aalbers, B. L.; Raeven, H. H. M.; Aarts, E. M.; Silva, I. A. L.; Nijenhuis, W.; Vrendenbarg, S.; Kruisselbrink, E.; Brunsveld, J.; van Drunen, C. M.; Michel, S.; de Winter-de Groot, K. M.; Heijerman, H. G.; Kapitein, L. C.; Amaral, M. D.; van der Ent, C. K.; Beekman, J. M.
10.1101/2021.07.20.453105 — cell biology — Posted on 2021-07-21
1321 Defining the prototypical DNA replication fork trap in bacteria
Schaeffer, P. M.; Ellington, A.; Perutka, J.; Enyeart, P.; Mandapati, S.; Moreau, M.; Toft, C.; Sorenson, A.; Perutka, J.
10.1101/2021.07.20.453168 — molecular biology — Posted on 2021-07-21
1322 Distinct Colon Mucosa Microbiomes associated with Tubular Adenomas and Serrated Polyps
Avelar-Barragan, J.; DeDecker, L.; Lu, Z.; Coppedge, B.; Karnes, W.; Whiteson, K.
10.1101/2021.07.20.453135 — microbiology — Posted on 2021-07-21
1323 Functional interactomes of the Ebola virus polymerase identified by proximity proteomics in the context of viral replication
Fang, J.; Pietzsch, C.; Tsaprailis, G.; Crynen, G.; Cho, K. F.; Ting, A. Y.; Bukreyev, A.; de la Torre, J. C.; Saphire, E. O.
10.1101/2021.07.20.453153 — microbiology — Posted on 2021-07-21
1324 Escaping the Fate of Sisyphus: Assessing Resistome Hybridization Baits for Antimicrobial Resistance Gene Capture
Beaudry, M. S.; Thomas, J. C.; Baptista, R.; Sullivan, A.; Norfolk, W.; Devault, A.; Enk, J.; Kieran, T.; Rhodes, O.; Perry, A.; Rose, L.; Bayona-Vasquez, N.; Oladeine, A.; Lipp, E. K.; Sanchez, S.; Glenn, T.
10.1101/2021.07.20.452950 — microbiology — Posted on 2021-07-21
1325 The gut microbiome is associated with cocaine behavior and predicts addiction vulnerability in adult male rats
Suess, G. J.; Kasiah, J.; Simpson, S.; Brennan, M.; Conlisk, D.; Maturin, L.; George, O.; Chassaing, B.; Frantz, K. J.
10.1101/2021.07.20.453110 — neuroscience — Posted on 2021-07-21
1333 Mutations in coral soma and sperm imply lifelong stem cell differentiation
Lopez-Nandam, E. H.; Albright, R.; Hanson, E. A.; Sheets, E. A.; Palumbi, S. R.
10.1101/2021.07.20.453148 — genetics — Posted on 2021-07-21
1339 Nonlinear Functional Network Connectivity In Resting fMRI Data
Motlaghian, S.; Belger, A.; Bustillo, J.; Ford, J.; Lim, K.; Mathalon, D.; Mueller, B.; Oleary, D.; Pearlson, G.; Potkin, S.; Preda, A.; Van Erp, T.; Calhoun, V.
10.1101/2021.07.20.452982 — neuroscience — Posted on 2021-07-21
1348 CoVizu: Rapid analysis and visualization of the global diversity of SARS-CoV-2 genomes
Ferreira, R.-C.; Wong, E.; Gugan, G.; Wade, K.; Liu, M.; Munoz Baena, L.; Chato, C.; Lu, B.; Olabode, A. S.; Poon, A.
10.1101/2021.07.20.453079 — bioinformatics — Posted on 2021-07-21
1349 Rapamycin microparticles induce autophagy, prevent senescence and are effective in treatment of Osteoarthritis
Dhanabalan, K. M.; Dravid, A. A.; Agarwal, S.; Sharath, R. K.; Padmanabhan, A. K.; Agarwal, R.
10.1101/2021.07.20.453073 — bioengineering — Posted on 2021-07-21
1351 Tempo of degeneration across independently evolved non-recombining regions
Carpentier, F.; Rodriguez De La Vega, R.; Perlin, M. H.; Wallen, M.; Hood, M.; Giraud, T.
10.1101/2021.07.20.453045 — evolutionary biology — Posted on 2021-07-21
1352 An untargeted metabolomic approach to identify antiviral defense mechanisms in memory leukocytes secreting in vitro IgG anti-SARS-Cov-2
Timperio, A. M.; Gevi, F.; Fanelli, G.; Lelli, V.; Zarletti, G.; Tiberi, M.; De Molfetta, V.; Scapigliati, G.
10.1101/2021.07.20.453042 — cell biology — Posted on 2021-07-21
1353 Circulating osteopontin released by injured kidneys causes pulmonary inflammation and edema
Khamissi, F. Z.; Ning, L.; Kefaloyianni, E.; Dun, H.; Arthanarisami, A.; Keller, A.; Atkinson, J. J.; Li, W.; Wong, B. W.; Dietmann, S.; Lavine, K.; Kreisel, D.; Herrlich, A.
10.1101/2021.07.20.452998 — cell biology — Posted on 2021-07-21
1355 A chimeric KaiA-like regulator extends the nonstandard KaiB3-KaiC3 clock system in bacteria
Koebler, C.; Schmelling, N. M.; Pawlowski, A.; Spaet, P.; Scheurer, N. M.; Berwanger, L.; Macek, B.; Axmann, I. M.; Wilde, A.
10.1101/2021.07.20.453058 — microbiology — Posted on 2021-07-21
1356 Cornering an Ever-Evolving Coronavirus: TATX-03, a fully human synergistic multi-antibody cocktail targeting the SARS-CoV-2 Spike Protein with in vivo efficacy
Roodink, I.; van Erp, M.; Li, A.; Potter, S.; van Duijnhoven, S. M. J.; Kuipers, A. J.; Kazemier, B.; van Geffen, E.; Hemrika, W.; Berkeveld, B.; Sonnemans, G.; de Vries, B. S.; Boers, B.; Smits, M.; Meurs, S.; de Pooter, M.; Thom, A.; Duplantis, B. N.; Romijn, R. A.; Houser, J. S.; Bath, J.; Abdiche, Y. N.
10.1101/2021.07.20.452858 — immunology — Posted on 2021-07-21
1357 An Orally Available Cathepsin L Inhibitor Protects Lungs Against SARS-CoV-2-Induced Diffuse Alveolar Damage in African Green Monkeys
Frueh, F. W.; Maneval, D. C.; Bohm, R. P.; Dufour, J. P.; Blair, R. V.; Simpson, S.; Powell, K.; Aye, P. P.; Golden, N. A.; ROY, C. J.; Spencer, S.; Russell-Lodrigue, K.; Plante, K. S.; Plante, J. A.; McKerrow, J. H.; Rappaport, J.
10.1101/2021.07.20.453127 — immunology — Posted on 2021-07-21
1360 Modelling spinal locomotor circuits for movements in developing zebrafish
Roussel, Y.; Gaudreau, S. F.; Kacer, E. R.; Sengupta, M.; Bui, T. V.
10.1101/2021.02.10.430671 — neuroscience — Posted on 2021-07-21
1361 Forearm and hand muscles exhibit high coactivation and overlapping of cortical motor representations
Pazin Tardelli, G.; Souza, V. H.; Hiroshi Matsuda, R.; Cavalcanti Garcia, M. A.; Nazarova, M.; Novikov, P.; Baffa, O.
10.1101/2021.07.20.453121 — neuroscience — Posted on 2021-07-21
1364 Discovery of nanobodies against SARS-CoV-2 and an uncommon neutralizing mechanism
Li, D.; Li, T.; Zhou, B.; Luo, Z.; Lai, Y.; Huang, S.; Zhou, Y.; Gautam, A.; Bourgeau, S.; Wang, S.; Bao, J.; Tan, J.; Lavillette, D.
10.1101/2021.07.20.453054 — biochemistry — Posted on 2021-07-21
1365 GCAT|Panel, a comprehensive structural variant haplotype map of the Iberian population from high-coverage whole-genome sequencing
Valls-Margarit, J.; Galvan-Femenia, I.; Matias, D.; Blay, N.; Puiggros, M.; Carreras, A.; Salvoro, C.; Cortes, B.; Amela, R.; Farre, X.; Lerga-Jaso, J.; Puig, M.; Sanchez-Herrero, J. F.; Moreno, V.; Perucho, M.; Sumoy, L.; Armengol, L.; Delaneau, O.; Caceres, M.; de Cid, R.; Torrents, D.
10.1101/2021.07.20.453041 — genomics — Posted on 2021-07-21
1366 Integrin activation is an essential component of SARS-CoV-2 infection
Simons, P.; Rinaldi, D.; Bondu, V.; Kell, A.; Bradfute, S.; Lidke, D.; Buranda, T.
10.1101/2021.07.20.453118 — cell biology — Posted on 2021-07-21
1367 SARS-CoV-2 Restructures the Host Chromatin Architecture
Wang, R.; Lee, J.-H.; Xiong, F.; Kim, J.; Al Hasani, L.; Yuan, X.; Shivshankar, P.; Krakowiak, J.; Qi, C.; Wang, Y.; Eltzschig, H. K.; Li, W.
10.1101/2021.07.20.453146 — molecular biology — Posted on 2021-07-21
1368 BashTheBug: a crowd of volunteers reproducibly and accurately measure the minimum inhibitory concentrations of 13 antitubercular drugs from photographs of 96-well broth microdilution plates.
Fowler, P. W.; Wright, C.; Spiers-Bowers, H.; Zhu, T.; Baeten, E. M.; Hoosdally, S. W.; Gibertoni Cruz, A. L.; Roohi, A.; Kouchaki, S.; Walker, T. M.; Peto, T. E.; Miller, G.; Lintott, C.; Clifton, D.; Crook, D. W.; Walker, A. S.; The CRyPTIC Consortium,
10.1101/2021.07.20.453060 — microbiology — Posted on 2021-07-21
1369 PRE-CLINICAL IMMUNE RESPONSE AND SAFETY EVALUATION OF THE PROTEIN SUBUNIT VACCINE NANOCOVAX FOR COVID-19
Tran, T. N. M.; May, B.; Ung, T. T.; Nguyen, M. K.; Nguyen, T. T.; Dinh, V. L.; Tran, T. V.; Khong, H.; Nguyen, T. T.; Hua, H. Q. H.; Nguyen, V. A.; Ha, T. P.; Phan, D. L.; Nguyen, T. A.; Bui, T. N.; Tu, T. M.; Nguyen, T. T.; Le, T. H.; Dong, T. L.; Huynh, T. H.; Truong, C. T.; Nie, L.; Cao, M. N.; Nguyen, D. K.; Trinh, T. H.; Do, M. S.
10.1101/2021.07.20.453162 — immunology — Posted on 2021-07-21
1370 Immunogenic SARS-CoV2 Epitopes Defined by Mass Spectrometry
Pan, K.; Chiu, Y.; Huang, E.; Chen, M.; Wang, J.; Lai, I.; Singh, S.; Shaw, R.; MacCoss, M. J.; Yee, C.
10.1101/2021.07.20.453160 — immunology — Posted on 2021-07-21
1371 Viral receptor profiles of masked palm civet revealed by single-cell transcriptomics
Chen, D.; Ou, Z.; Wang, H.; Zhang, Y.; Zhu, J.; An, F.; Xu, J.; Ding, X.; Ding, P.; Luo, L.; Wu, W.; Qin, Q.; Wei, Y.; Zhao, W.; Lv, Z.; Lan, T.; Li, M.; Zhang, W.; Liu, H.; Hua, Y.
10.1101/2021.07.20.452903 — immunology — Posted on 2021-07-21
1373 Measuring fingerpad deformation during active object manipulation
Delhaye, B. P.; Schiltz, F.; Barrea, A.; Thonnard, J.-L.; Lefevre, P.
10.1101/2021.07.20.453037 — neuroscience — Posted on 2021-07-21
1375 A mechano-osmotic feedback couples cell volume to the rate of cell deformation
Venkova, L.; Vishen, A. S.; Lembo, S.; Srivastava, N.; Duchamp, B.; Ruppel, A.; Vassilopoulos, S.; Deslys, A.; Garcia Arcos, J. M.; Diz-Munoz, A.; Balland, m.; Joanny, J.-F.; Cuvelier, D.; Sens, P.; Piel, M.
10.1101/2021.06.08.447538 — biophysics — Posted on 2021-07-21
1376 Crystal structures of taxane-tubulin complexes: Implications for the mechanism of microtubule stabilization by Taxol
Prota, A. E.; Lucena-Agell, D.; Ma, Y.; Estevez-Gallego, J.; Roca, C.; Josa-Prado, F.; Goossens, K.; Gimenez-Abian, J. F.; Li, S.; Canales, A.; Bargsten, K.; Andreu, J. M.; Altmann, K.-H.; Olieric, N.; Kamimura, S.; Muehlethaler, T.; Oliva, M. A.; Steinmetz, M. O.; Fang, W.-S.; Diaz, J. F.
10.1101/2021.07.20.453061 — biophysics — Posted on 2021-07-21
1377 CryoEM structure of the outer membrane secretin channel pIV from the f1 filamentous bacteriophage
Conners, R.; McLaren, M.; Lapinska, U.; Sanders, K.; Stone, M. R. L.; Blaskovich, M. A. T.; Pagliara, S.; Daum, B.; Rakonjac, J.; Gold, V. A. M.
10.1101/2021.07.20.453082 — biophysics — Posted on 2021-07-21
1381 Antibiotics drive expansion of rare pathogens in a chronic infection microbiome model
Varga, J. J.; Zhao, C.; Davis, J. D.; Hao, Y.; Farrell, J. M.; Gurney, J. R.; Voit, E.; Brown, S. P.
10.1101/2021.06.21.449018 — microbiology — Posted on 2021-07-21
1386 The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth
Sandovici, I.; Georgopoulou, A.; Perez-Garcia, V.; Hufnagel, A. S.; Lopez-Tello, J.; Lam, B. Y. H.; Schiefer, S. N.; Gaudreau, C.; Santos, F.; Hoelle, K.; Yeo, G. S. H.; Burling, K.; Reiterer, M.; Fowden, A. L.; Burton, G. J.; Sferruzzi-Perri, A. N.; Branco, C. M.; Constancia, M.
10.1101/520536 — developmental biology — Posted on 2021-07-21
1390 ASXL3 controls cortical neuron fate specification through extrinsic self-renewal pathways
McGrath, B. T.; Wu, P.; Salvi, S.; Girgla, N.; Xu, C.; Zhu, J.; KC, R.; Tsan, Y.-C.; Moccia, A.; Srivastava, A.; Zhou, X.; Bielas, S. L.
10.1101/2021.07.20.452995 — neuroscience — Posted on 2021-07-21
1391 Comparison of Neutralizing Antibody Titers Elicited by mRNA and Adenoviral Vector Vaccine against SARS-CoV-2 Variants
Tada, T.; Zhou, H.; Samanovic, M. I.; Dcosta, B. M.; Cornelius, A.; Mulligan, M. J.; Landau, N. R.
10.1101/2021.07.19.452771 — immunology — Posted on 2021-07-21
1394 Highly potent anti-SARS-CoV-2 multivalent DARPin therapeutic candidates
Walser, M.; Rothenberger, S.; Hurdiss, D. L.; Schlegel, A.; Calabro, V.; Fontaine, S.; Villemagne, D.; Paladino, M.; Hospodarsch, T.; Neculcea, A.; Cornelius, A.; Schildknecht, P.; Matzner, M.; Haenggi, M.; Franchini, M.; Kaufmann, Y.; Schaible, D.; Schlegel, I.; Iss, C.; Looser, T.; Mangold, S.; Herzog, C.; Schiegg, D.; Reichen, C.; Radom, F.; Bosshart, A.; Lehmann, A.; Haeuptle, M. A.; Zuercher, A.; Vagt, T.; Sigrist, G.; Straumann, M.; Proba, K.; Veitonmaki, N.; Dawson, K. M.; Zitt, C.; Mayor, J.; Ryter, S.; Lyoo, H.; Wang, C.; Li, W.; Drulyte, I.; Du, W.; Binz, H. K.; de Waal, L.; Stittela
10.1101/2020.08.25.256339 — immunology — Posted on 2021-07-21
1396 Adult medial habenula neurons require GDNF receptor GFRalpha1 for synaptic stability and function
Fernandez-Suarez, D.; Krapacher, F.; Pietrajtis, K.; Andersson, A.; Kisiswa, L.; Diana, M.; Ibanez, C.
10.1101/2021.07.07.451421 — neuroscience — Posted on 2021-07-21
1397 Prevalence of Major Limb Loss (MLL) in Post conflict Acholi sub-region of Northern Uganda: Cross sectional study
Atim, P.; Loum, C. S.; Okello, T. R.; Magada, S. M.; Yagos, W. O.; Abelle, P.; Moro, E. B.; Huck, J.; Redmond, A.; Nirmalan, M.
10.1101/2020.05.14.095836 — scientific communication and education — Posted on 2021-07-21
1398 Deep learning-based segmentation and quantification of podocyte foot process morphology
Butt, L.; Unnersjoe-Jess, D.; Hoehne, M.; Sergei, G.; Witasp, A.; Wernerson, A.; Patrakka, J.; Hoyer, P. F.; Blom, H.; Schermer, B.; Bozek, K.; Benzing, T.
10.1101/2021.06.14.448284 — pathology — Posted on 2021-07-21
1399 Insights into Mus musculus subspecies population structure across Eurasia revealed by whole-genome sequence analysis
Fujiwara, K.; Kawai, Y.; Moriwaki, K.; Takada, T.; Shiroishi, T.; Saitou, N.; Suzuki, H.; Osada, N.
10.1101/2021.02.05.429881 — genomics — Posted on 2021-07-21
1400 Structural model of PORCN illuminates disease-associated variants and drug binding sites
Yu, J.; Liao, P.-J.; Xu, W.; Jones, J. R.; Everman, D. B.; Flanagan-Steet, H.; Keller, T. H.; Virshup, D. M.
10.1101/2021.07.19.452875 — molecular biology — Posted on 2021-07-21
1401 The Neural Basis of Delayed Gratification
Gao, Z.; Wang, H.; Lu, C.; Lu, T.; Froudist-Walsh, S.; Chen, M.; Wang, X.-J.; Hu, J.; Sun, W.
10.1101/2021.03.10.434739 — neuroscience — Posted on 2021-07-21
1404 Diverse human astrocyte and microglial transcriptional responses to Alzheimer's pathology
Smith, A.; Davey, K.; Tsartsalis, S.; Khozoie, C.; Fancy, N. N.; Tang, S. S.; Liaptsi, E.; Weinert, M.; McGarry, A.; Muirhead, R. C.; Gentleman, S.; Owen, D. R. J.; Matthews, P. M.
10.1101/2021.07.19.452932 — neuroscience — Posted on 2021-07-21
1405 Diverse human astrocyte and microglial transcriptional responses to Alzheimer's pathology
Matthews, P. M.; Davey, K.; Tsartsalis, S.; Khozoie, C.; Fancy, N. N.; Tang, S. S.; Liaptsi, E.; Weinert, M.; McGarry, A.; Muirhead, R. C.; Gentleman, S.; Owen, D. R. J.
10.1101/2021.07.19.452932 — neuroscience — Posted on 2021-07-20
1406 Development of an exosomal gene signature to detect residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning
Makielski, K.; Donnelly, A. J.; Khammanivong, A.; Scott, M. C.; Ortiz, A. R.; Galvan, D. C.; Tomiyasu, H.; Amaya, C.; Ward, K.; Montoya, A.; Garbe, J. R.; Mills, L. J.; Cutter, G. R.; Fenger, J. M.; Kisseberth, W. C.; O'Brien, T. D.; Weigel, B. J.; Spector, L. G.; Bryan, B. A.; Subramanian, S.; Modiano, J. F.
10.1101/2021.02.11.429432 — cancer biology — Posted on 2021-07-20
1408 Metabolic turnover and dynamics of modified ribonucleosides by 13C labeling
Gameiro, P. A.; Encheva, V.; Silva dos Santos, M.; MacRae, J. I.; Ule, J.
10.1101/2021.07.20.453046 — biochemistry — Posted on 2021-07-20
1410 Solid state NMR reveals a parallel in register architecture for an infectious recombinant prion
Martin-Pastor, M.; Codeseira, Y. B.; Spagnolli, G.; Erana, H.; Fernandez, L. C.; Martin, D.; Bravo, S.; Lopez-Lorenzo, N.; Iglesias, A.; Lopez-Moreno, R.; Sabate, R.; Veiga, S.; Rezaei, H.; Biasini, E.; Sanchez-Pedregal, V. M.; Castilla, J.; Requena, J. R.
10.1101/2021.07.20.453078 — biochemistry — Posted on 2021-07-20
1412 Transcription factor regulation of eQTL activity across individuals and tissues
Flynn, E.; Tsu, A. L.; Kasela, S.; Kim-Hellmuth, S.; Aguet, F.; Ardlie, K. G.; Bussemaker, H. J.; Mohammadi, P.; Lappalainen, T.
10.1101/2021.07.20.453075 — genomics — Posted on 2021-07-20
1414 Metagenome-genome-wide association studies reveal human genetic impact on the oral microbiome
Liu, X.; Tong, X.; Zhu, J.; Tian, L.; Jie, Z.; Zou, Y.; Lin, X.; Liang, H.; Li, W.; Ju, Y.; Qin, Y.; Zou, L.; Lu, H.; Xu, X.; Yang, H.; Wang, J.; Zong, Y.; Liu, W.; Hou, Y.; Zhu, S.; Jin, X.; Jia, H.; Zhang, T.
10.1101/2021.05.06.443017 — genetics — Posted on 2021-07-20
1417 A comparative network approach to assess the social-ecological underpinnings of zoonotic outbreaks at human-wildlife interfaces
Balasubramaniam, K. N.; Aiempichitkijkarn, N.; Kaburu, S. S. K.; Marty, P. R.; Beisner, B. A.; Bliss-Moreau, E.; Arlet, M. E.; Atwill, E. R.; McCowan, B.
10.1101/2021.07.19.452944 — ecology — Posted on 2021-07-20
1418 Mechanisms of translation inhibition and suppression of Stress Granule formation by cisplatin
Pietras, P.; Aulas, A.; Fay, M. M.; Lesniczak, M.; Lyons, S. M.; Szaflarski, W.; Ivanov, P.
10.1101/2021.07.20.452628 — cell biology — Posted on 2021-07-20
1420 Tensin3 interaction with talin drives formationof fibronectin-associated fibrillar adhesions
Atherton, P.; Konstantinou, R.; Neo, S. P.; Wang, E.; Balloi, E.; Ptushkina, M.; Bennett, H.; Clark, K.; Gunaratne, J.; Critchley, D.; Barsukov, I.; Manser, E.; Ballestrem, C.
10.1101/2021.07.16.452612 — cell biology — Posted on 2021-07-20
1421 ChAdOx1 NiV vaccination protects against lethal Nipah Bangladesh virus infection in African green monkeys
van Doremalen, N.; Avanzato, V.; Feldmann, F.; Schulz, J.; Haddock, E.; Okumura, A.; Lovaglio, J.; Hanley, P.; Cordova, K.; Saturday, G.; Lambe, T.; Gilbert, S. C.; Munster, V.
10.1101/2021.07.20.452991 — microbiology — Posted on 2021-07-20
1422 ENGINEERING, DECODING AND SYSTEMS-LEVEL CHARACTERIZATION OF CHIMPANZEE CYTOMEGALOVIRUS
Phan, Q. V.; Bogdanow, B.; Wyler, E.; Landthaler, M.; Liu, F.; Hagemeier, C.; Wiebusch, L.
10.1101/2021.07.20.453063 — microbiology — Posted on 2021-07-20
1423 Discovery of genes that modulate flavivirus replication in an interferon-dependent manner
Lesage, S.; Chazal, M.; Beauclair, G.; Batalie, D.; Couderc, E.; Lescure, A.; Del Nery, E.; Tangy, F.; Martin, A.; Manel, N.; jouvenet, n.
10.1101/2021.07.20.453077 — microbiology — Posted on 2021-07-20
1424 Immunodominant surface epitopes power immune evasion in the African trypanosome
Gkeka, A.; Aresta-Branco, F.; Triller, G.; Vlachou, E. P.; Lilic, M.; Olinares, P. D. B.; Perez, K.; Chait, B.; Blatnik, R.; Ruppert, T.; Stebbins, C. E.; Papavasiliou, F. N.
10.1101/2021.07.20.453071 — immunology — Posted on 2021-07-20
1425 Engineering well-expressed, V2-immunofocusing HIV-1 envelope glycoprotein membrane trimers for use in heterologous prime-boost vaccine regimens
Binley, J. M.; Crooks, E.; Almanza, F.; D'Addabbo, A.; Duggan, E.; Zhang, J.; Wagh, K.; Mou, H.; Allen, J.; Thomas, A.; Osawa, K.; Korber, B.; Tsybovsky, Y.; Cale, E.; Nolan, J.; Crispin, M.; Verkoczy, L.
10.1101/2021.07.20.453076 — immunology — Posted on 2021-07-20
1426 Engineered Bacteriophage T4 Nanoparticle as a Potential Targeted Activator of HIV-1 Latency in CD4+ Human T cells
Batra, H.; Zhu, J.; Jain, S.; Ananthaswamy, N.; Mahalingam, M.; Tao, P.; Lange, C.; Zhong, C.; Kearney, M. F.; Hu, H.; Maldarelli, F.; Rao, V. B.
10.1101/2021.07.20.453091 — immunology — Posted on 2021-07-20
1430 Deep learning-based segmentation and quantification of podocyte foot process morphology
Butt, L.; Unnersjoe-Jess, D.; Hoehne, M.; Sergei, G.; Witasp, A.; Wernerson, A.; Patrakka, J.; Hoyer, P. F.; Blom, H.; Schermer, B.; Bozek, K.; Benzing, T.
10.1101/2021.06.14.448284 — pathology — Posted on 2021-07-20
1432 Environmentally sensitive hotspots in the methylome of the early human embryo
Silver, M. J.; Saffari, A.; Kessler, N. J.; Chandak, G. R.; Fall, C. H.; Issarapu, P.; Dedaniya, A.; Betts, M.; Moore, S. E.; Routledge, M. N.; Herceg, Z.; Cuenin, C.; Derakhshan, M.; James, P. T.; Monk, D.; Prentice, A. M.
10.1101/777508 — genomics — Posted on 2021-07-20
1433 Benchmarking ultra-high molecular weight DNA preservation methods for long-read and long-range sequencing
Dahn, H. A.; Mountcastle, J.; Balacco, J.; Winkler, S.; Bista, I.; Schmitt, A. D.; Vinnere Pettersson, O.; Formenti, G.; Oliver, K.; Smith, M.; Tan, W.; Kraus, A.; Mac, S.; Komoroske, L. M.; Lama, T.; Crawford, A. J.; Murphy, R. W.; Brown, S.; Scott, A. F.; Morin, P. A.; Jarvis, E. D.; Fedrigo, O.
10.1101/2021.07.13.451380 — genomics — Posted on 2021-07-20
1434 Spontaneous emergence of multicellular heritability
Zamani-Dahaj, S. A.; Burnetti, A.; Day, T. C.; Yunker, P. J.; Ratcliff, W. C.; Herron, M. D.
10.1101/2021.07.19.452990 — evolutionary biology — Posted on 2021-07-20
1436 SUV39 SET domains mediate crosstalk of heterochromatic histone marks
Stirpe, A.; Guidotti, N.; Northall, S.; Kilic, S.; Hainard, A.; Vadas, O.; Fierz, B.; Schalch, T.
10.1101/2020.06.30.177071 — molecular biology — Posted on 2021-07-20
1443 A Bayesian model selection approach to mediation analysis
Crouse, W. L.; Keele, G. R.; Gastonguay, M. S.; Churchill, G. A.; Valdar, W.
10.1101/2021.07.19.452969 — genetics — Posted on 2021-07-20
1446 Decoding regulatory specificity of human ribosomal proteins
Luan, Y.; Tang, N.; Yang, J.; Chen, C.; Liu, S.; Cheng, C.; Wang, Y.; Guo, Y.; Wang, H.; Xiang, M.; Ju, R.; Xie, Z.
10.1101/2021.03.27.437302 — cell biology — Posted on 2021-07-20
1447 Cross-tissue immune cell analysis reveals tissue-specific adaptations and clonal architecture across the human body
Dominguez Conde, C.; Gomes, T.; Jarvis, L. B.; Xu, C.; Howlett, S.; Rainbow, D.; Suchanek, O.; King, H.; Mamanova, L.; Polanski, K.; Huang, N.; Fasouli, E.; Mahbubani, K.; Prete, M.; Tuck, E.; Richoz, N.; Tuong, K.; Campos, L.; Mousa, H.; Needham, E.; Pritchard, S.; Li, T.; Elmentaite, R.; Park, J.; Menon, D.; Bayraktar, O.; James, L.; Meyer, K.; Clatworthy, M.; Saeb-Parsy, K.; Jones, J. L.; Teichmann, S. A.
10.1101/2021.04.28.441762 — immunology — Posted on 2021-07-20
1448 Reduction in CD11c+ microglia correlates with clinical progression in chronic experimental autoimmune demyelination
Mayrhofer, F.; Dariychuk, Z.; Zhen, A.; Daugherty, D. J.; Bannerman, P.; Hanson, A. M.; Pleasure, D. E.; Soulika, A.; Deng, W.; Chechneva, O.
10.1101/396036 — neuroscience — Posted on 2021-07-20
1450 Deep learning and cross-species analysis identify the influences of sex and cannabinoidsignaling on cerebellar vermis morphology
Black, K. C.; McPherson, B. C.; Hainline, J.; Baygani, S.; Webb, B.; Mier, T. J.; Essex, A.; Mackie, K.; Pestilli, F.; Kalinovsky, A.
10.1101/2021.07.03.450642 — neuroscience — Posted on 2021-07-20
1451 Cognitive functions and underlying parameters of human brain physiology are associated with chronotype
Salehinejad, M. A.; Wischnewski, M.; Ghanavati, E.; Mosayebi-Samani, M.; Kuo, M.-F.; Nitsche, M. A.
10.1101/2021.06.08.447543 — neuroscience — Posted on 2021-07-20
1452 Loss of Nuclear DNA Ligase III Reverts PARP Inhibitor Resistance in BRCA1/53BP1 Double-deficient Cells by Exposing ssDNA Gaps
Paes Dias, M.; Tripathi, V.; Heijden, I. v. d.; Cong, K.; Manolika, E.-M.; Bhin, J.; Gogola, E.; Galanos, P.; Annunziato, S.; Lieftink, C.; Andujar-Sanchez, M.; Chakrabarty, S.; Smith, G. C. M.; Ven, M. v. d.; Beijersbergen, R. L.; Bartkova, J.; Rottenberg, S.; Cantor, S.; Bartek, J.; Chaudhuri, A. R.; Jonkers, J.
10.1101/2021.03.24.436323 — cancer biology — Posted on 2021-07-20
1453 Lipid-induced polymorphic amyloid fibrils formation by α-synuclein.
Singh, B. P.; Morris, R. J.; Horrocks, M. H.; Kunath, T.; MacPhee, C. E.
10.1101/2021.07.20.453062 — biophysics — Posted on 2021-07-20
1461 Myotubularin-related phosphatase 5 is a critical determinant of autophagy in neurons
Chua, J. P.; Bedi, K.; Paulsen, M. T.; Ljungman, M.; Tank, E. M. H.; Kim, E. S.; Colon-Mercado, J. M.; Ward, M. E.; Weisman, L. S.; Barmada, S. J.
10.1101/2021.07.20.453106 — neuroscience — Posted on 2021-07-20
1465 Previously unrecognized non-reproducible antibody-antigen interactions and their implications for diagnosis of viral infections including COVID-19
Pan, J.; Yang, L.; Deng, Y.; Sun, B.; Zhang, L.; Wu, W.; Li, J.; Cheng, H.; Li, Y.; Xu, W.; Yang, J.; Sun, Y.; Fei, H.; Xue, Q.; Zhou, Y.; Wang, H.; Zheng, P.; Chen, H.; Zhu, F. C.; Peng, D.; Gu, D.; Han, J.; Qiu, J.; Ma, H.
10.1101/2021.07.20.453011 — immunology — Posted on 2021-07-20
1466 HLA-dependent variation in SARS-CoV-2 CD8+ T cell cross-reactivity with human coronaviruses
Buckley, P.; Lee, C. H.-j.; Pinho, M. P.; Babu, R. O.; Woo, J.; Antanaviciute, A.; Simmons, A.; Ogg, G.; Koohy, H.
10.1101/2021.07.17.452778 — immunology — Posted on 2021-07-20
1467 The SARS-CoV-2 reproduction number R0 in cats
Gonzales, J. L.; De Jong, M. C. M.; Gerhards, N. M.; Van der Poel, W. H. M.
10.1101/2021.07.20.453027 — microbiology — Posted on 2021-07-20
1468 CRISPR screens for host factors critical for infection by SARS-CoV-2 variants of concern identify GATA6 as a central modulator of ACE2.
Israeli, M.; Finkel, Y.; Israeli, O.; Beth-Din, A.; Cohen-Gihon, I.; Yahalom-Rone, Y.; Paran, N.; Israely, T.; Chitlaru, T.; Elia, U.; Cohen, O.; Nemet, I.; Kliker, L.; Mandelboim, M.; Stern-Ginossar, N.; Bercovich-Kinori, A.
10.1101/2021.07.19.452809 — microbiology — Posted on 2021-07-20
1469 The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147-receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease
Avolio, E.; Carrabba, M.; Milligan, R.; Kavanagh Williamson, M.; Beltrami, A. P.; Gupta, K.; Elvers, K. T.; Gamez, M.; Foster, R.; Gillespie, K.; Hamilton, F.; Arnold, D.; Berger, I.; Caputo, M.; Davidson, A. D.; Hill, D.; Madeddu, P.
10.1101/2020.12.21.423721 — cell biology — Posted on 2021-07-20
1470 Phylogenomic analyses of echinoid diversification prompt a re-evaluation of their fossil record
Mongiardino Koch, N.; Thompson, J. R.; Hatch, A. S.; McCowin, M. F.; Armstrong, F.; Coppard, S. E.; Aguilera, F.; Bronstein, O.; Kroh, A.; Mooi, R.; Rouse, G.
10.1101/2021.07.19.453013 — evolutionary biology — Posted on 2021-07-20
1471 Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains
Gao, A. W.; El Alam, G.; Lalou, A.; Li, T. Y.; Molenaars, M.; Zhu, Y.; Overmyer, K. A.; Shishkova, E.; Hof, K.; Bou Sleiman, M. S.; Houtkooper, R. H.; Coon, J.; Auwerx, J.
10.1101/2021.07.20.453059 — systems biology — Posted on 2021-07-20
1472 Tissue-engineered collagenous fibrous cap models to systematically elucidate atherosclerotic plaque rupture.
Wissing, T. B.; Van der Heiden, K.; Serra, S. M.; Smits, A. I. P. M.; Bouten, C. V. C.; Gijsen, F.
10.1101/2021.07.20.451997 — bioengineering — Posted on 2021-07-20
1473 Patterns of mesozooplankton community composition and vertical fluxes in the global ocean
Soviadan, Y. D.; benedetti, f.; brandao, m.; ayata, s. d.; Irisson, j. o.; jamet, j. l.; kiko, r.; Lombard, F.; Gnandi, K.; stemmann, l.
10.1101/2021.07.20.452978 — ecology — Posted on 2021-07-20
1474 MCPH1 inhibits condensin II during interphase by regulating its SMC2-kleisin interface.
Houlard, M.; Cutts, E.; S. Shamim, M.; Godwin, J.; Weisz, D.; Presser Aiden, A.; Lieberman Aiden, E.; Schermelleh, L.; Vannini, A.; Nasmyth, K.
10.1101/2021.07.20.453033 — cell biology — Posted on 2021-07-20
1475 Integration of the cyanophage-encoded phosphate binding protein into the cyanobacterial phosphate uptake system
Zhao, F.; Lin, X.; Cai, K.; Jiang, Y.; Ni, T.; Chen, Y.; Feng, J.; Dang, S.; Zhou, C.-Z.; Zeng, Q.
10.1101/2021.07.20.453049 — microbiology — Posted on 2021-07-20
1479 Facilitation of TRKB activation by the angiotensin II receptor type-2 (AT2R) agonist C21
Laukkanen, L.; Dinz, C. R. A. F.; Foulquier, S.; Prickaerts, J.; Castren, E.; Casarotto, P. C.
10.1101/2021.07.20.453028 — pharmacology and toxicology — Posted on 2021-07-20
1480 Somatic point mutations are enriched in long non-coding RNAs with possible regulatory function in breast cancer
Rezaie, N.; Bayati, M.; Tahaei, M. S.; Hamidi, M.; Khorasani, S.; Lovell, N. H.; Breen, J.; Rabiee, H. R.; Alinejad-Rokny, H.
10.1101/2021.07.19.453012 — cancer biology — Posted on 2021-07-20
1481 Imaging biological samples by integrated differential phase contrast (iDPC) STEM technique
Li, X.; Lazic, I.; Huang, X.; Wang, L.; Deng, Y.; Niu, T.; Wu, D.; Wirix, M.; Yu, L.; Sun, F.
10.1101/2021.07.20.453030 — biophysics — Posted on 2021-07-20
1484 FISH-quant v2: a scalable and modular analysis tool for smFISH image analysis
Imbert, A.; Ouyang, W.; Safieddine, A.; Coleno, E.; Zimmer, C.; Bertrand, E.; Walter, T.; Mueller, F.
10.1101/2021.07.20.453024 — bioinformatics — Posted on 2021-07-20
1487 Strategies of tolerance reflected in two North American maple genomes
McEvoy, S. L.; Sezen, U. U.; Trouern-Trend, A.; McMahon, S. M.; Schaberg, P. G.; Yang, J.; Wegrzyn, J. L.; Swenson, N. G.
10.1101/2021.07.19.452996 — genomics — Posted on 2021-07-20
1492 Fast grip force adaptation to friction relies on localized fingerpad strains
Schiltz, F.; Delhaye, B. P.; Crevecoeur, F.; Thonnard, J.-L.; Lefevre, P.
10.1101/2021.07.20.452911 — neuroscience — Posted on 2021-07-20
1494 Sex differences in tissue gene regulation -- contributions of three classes of sex-biasing factors
Blencowe, M.; Itoh, Y.; Chen, X.; Zhao, Y.; Han, Y.; Shou, B.; McClusky, R.; Reue, K.; Arnold, A. P.; Yang, X.
10.1101/2021.07.18.451543 — systems biology — Posted on 2021-07-20
1495 The diversity of quinoa morphological traits and seed metabolic composition
Tabatabaei, I.; Alseekh, S.; Shahid, M.; Leniak, E.; Wagner, M.; Mahmoudi, H.; Thushar, S.; Fernie, A. R.; Murrphy, K. M.; Schmöckel, S. M.; Tester, M.; Mueller-Roeber, B.; Skirycz, A.; Balazadeh, S.
10.1101/2021.07.17.452781 — plant biology — Posted on 2021-07-20
1496 A dynamic and combinatorial histone code drives malaria parasite asexual and sexual development
von Grüning, H.; Coradin, M.; Mendoza, M.; Reader, J.; Sidoli, S.; Garcia, B.; Birkholtz, L.-M.
10.1101/2021.07.19.452879 — biochemistry — Posted on 2021-07-20
1497 Gene co-expression reveals the modularity and integration of C4 and CAM in Portulaca
Gilman, I. S.; Moreno-Villena, J. J.; Lewis, Z. R.; Goolsby, E. W.; Edwards, E. J.
10.1101/2021.07.07.451465 — evolutionary biology — Posted on 2021-07-20
1498 Intramembrane protease SPP defines a cholesterol-regulated switch of the mevalonate pathway
Heidasch, R.; Avci, D.; Lüchtenborg, C.; Kale, D.; Beard, H.; Mentrup, T.; Barniol-Xicota, M.; Schröder, B.; verhelst, S.; Brügger, B.; Lemberg, M. K.
10.1101/2021.07.19.452877 — cell biology — Posted on 2021-07-20
1499 Intrabody induced cell death by targeting the T. brucei cytoskeletal protein TbBILBO1
Broster-Reix, C. E.; Ramanantsalama, M. R.; Di Primo, C.; Minder, L.; Bonhivers, M.; Dacheux, D.; Robinson, D. R.
10.1101/2021.07.18.452872 — cell biology — Posted on 2021-07-20
1500 Rapid visual CRISPR assay: a naked-eye colorimetric detection method for nucleic acids based on CRISPR/Cas12a and convolutional neural network
Xie, S.; Tao, D.; Fu, Y.; Xu, B.; Tang, Y.; Lucilla, S.; Hanneke, H.; Pan, W.; Huang, X.; Zhao, C.; Ruan, J.; Fu, L.; Nie, X.; Zhang, Y.; Han, J.; Ma, Y.; Li, X.; Liu, X.; Zhao, S.
10.1101/2021.07.17.452802 — molecular biology — Posted on 2021-07-20
1501 Comparison of heat-inactivated and infectious SARS-CoV-2 across indoor surface materials shows comparable RT-qPCR viral signal intensity and persistence
Salido, R. A.; Cantu, V. J.; Clark, A. E.; Leibel, S. L.; Foroughishafiei, A.; Saha, A.; Hakim, A.; Nouri, A.; Lastrella, A. L.; Castro-Martinez, A.; Plascencia, A.; Kapadia, B.; Xia, B.; Ruiz, C.; Marotz, C.; Maunder, D.; Lawrence, E. S.; Smoot, E. W.; Eisner, E.; Crescini, E. S.; Kohn, L.; Franco Vargas, L.; Chacon, M.; Betty, M.; Machnicki, M.; Wu, M. Y.; Baer, N. A.; Belda-Ferre, P.; DeHoff, P.; Saever, P.; Ostrander, R. T.; Tsai, R.; Sathe, S.; Aigner, S.; Morgan, S. C.; Ngo, T. T.; Barber, T.; Cheung, W.; Carlin, A. F.; Yeo, G. W.; Laurent, L.; Fielding-Miller, R.; Knight, R.
10.1101/2021.07.16.452756 — microbiology — Posted on 2021-07-20
1502 Genomic epidemiology and strain taxonomy of Corynebacterium diphtheriae
Guglielmini, J.; Hennart, M.; Badell, E.; Toubiana, J.; Criscuolo, A.; Brisse, S.
10.1101/2021.07.18.452871 — microbiology — Posted on 2021-07-20
1503 Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells
Rothenburger, T.; Thomas, D.; Schreiber, Y.; Wratil, P. R.; Pflantz, T.; Knecht, K.; Digianantonio, K.; Temple, J.; Schneider, C.; Baldauf, H.-M.; McLaughlin, K.-M.; Rothweiler, F.; Bilen, B.; Farmand, S.; Bojkova, D.; Costa, R.; Ferreiros, N.; Geisslinger, G.; Oellerich, T.; Xiong, Y.; Keppler, O. T.; Wass, M. N.; Michaelis, M.; Cinatl, J.
10.1101/2021.07.19.452885 — pharmacology and toxicology — Posted on 2021-07-20
1506 Spontaneous emergence of multicellular heritability
Zamani-Dahaj, S. A.; Burnetti, A.; Day, T.; Ratcliff, w. C.; Yunker, P. J.; Herron, M. D.
10.1101/2021.07.19.452990 — evolutionary biology — Posted on 2021-07-20
1515 Cardiac-generated sympathetic stress alters heart-brain communication, reduces EEG-theta activity, and increases locomotor behavior
Agrimi, J.; Menicucci, D.; Laurino, M.; Mackey, C.; Hasnain, L.; Dodaballapur, S.; McDevit, R. A.; Hoover, D. B.; Gemignani, A.; Paolocci, N.; Lakatta, E. G.
10.1101/2021.07.19.452502 — physiology — Posted on 2021-07-20
1522 A Bayesian model selection approach for mediation analysis
Crouse, W. L.; Keele, G. R.; Gastonguay, M. S.; Churchill, G. A.; Valdar, W.
10.1101/2021.07.19.452969 — genetics — Posted on 2021-07-20
1523 An improved auxin-inducible degron system for fission yeast
Zhang, X.-R.; Zhao, L.; Suo, F.; Gao, Y.; Wu, Q.; Qi, X.; Du, L.-L.
10.1101/2021.07.19.452993 — genetics — Posted on 2021-07-20
1529 Ecotoxicological effects of silver nanoparticles in marine mussels
Calisi, A.; Lorusso, C.; Gallego Urrea, J. A.; Hassellov, M.; Dondero, F.
10.1101/2021.07.19.452197 — ecology — Posted on 2021-07-20
1530 The self-peptide repertoire plays a critical role in transplant tolerance induction
Son, E. T.; Faridi, P.; Paul-Heng, M.; Leong, M.; English, K.; Ramarathinam, S. H.; Braun, A.; Dudek, N.; Alexander, I. E.; Lisowski, L.; Bertolino, P.; Bowen, D.; Purcell, A. W.; Mifsud, N.; Sharland, A. F.
10.1101/2020.11.09.359968 — immunology — Posted on 2021-07-20
1540 Hyperspectral characterisation of natural illumination in woodland and forest environments
Shiwen, L.; Steel, L.; Dahlsjö, C. A. L.; Peirson, S. N.; Shenkin, A.; Morimoto, T.; Smithson, H. E.; Spitschan, M.
10.1101/2021.07.19.452949 — systems biology — Posted on 2021-07-20
1542 CHOmpact: a reduced metabolic model of Chinese hamster ovary cells with enhanced interpretability
Jimenez del Val, I.; Kyriakopoulos, S.; Albrecht, S.; Stöckmann, H.; Rudd, P. M.; Polizzi, K. M.; Kontoravdi, C.
10.1101/2021.07.19.452953 — systems biology — Posted on 2021-07-20
1544 Identification of green lineage osmotic stress pathways
Vilarrasa-Blasi, J.; Vellosillo, T.; Jinkerson, R. E.; Fauser, F.; Xiang, T.; Minkoff, B. B.; Wang, L.; Kniazev, K.; Guzman, M.; Osaki, J.; Sussman, M. R.; Jonikas, M. C.; Dinneny, J. R.
10.1101/2021.07.19.453009 — plant biology — Posted on 2021-07-20
1545 Energetics but not development is impacted in coral embryos exposed to ocean acidification
Chille, E. E.; Strand, E. L.; Scucchia, F.; Schmidt, V.; Neder, M.; Sherman, M. O.; Mass, T.; Putnam, H. M.
10.1101/2021.07.19.452948 — physiology — Posted on 2021-07-20
1551 Absolute copy number fitting from shallow whole genome sequencing data
Sauer, C. M.; Eldridge, M. D.; Vias, M.; Hall, J. A.; Boyle, S. E.; Macintyre, G.; Bradley, T.; Markowetz, F.; Brenton, J. D.
10.1101/2021.07.19.452658 — bioinformatics — Posted on 2021-07-20
1552 Cell minor-axis length is a critical feature for breast cancer cell migration on straight, wavy, loop and grid microfibre patterns
Zhang, D.; Sheng, Y.; Piano, N.; Jakuszeit, T.; Cozens, E.; Dong, L.; Lei, I. M.; Wang, A.; Terentjev, E. M.; Huang, Y. Y. S.
10.1101/2021.07.19.452928 — bioengineering — Posted on 2021-07-20
1553 Construction of functional biliary epithelial branched networks with predefined geometry using digital light stereolithography
Mazari-Arrighi, E.; Ayollo, D.; Farhat, W.; Marret, A.; Gontran, E.; Dupuis-Williams, P.; Larghero, J.; Chatelain, F.; Fuchs, A.
10.1101/2021.07.19.452904 — bioengineering — Posted on 2021-07-20
1554 Data-Driven Strain Design Using Aggregated Adaptive Laboratory Evolution Mutational Data
Phaneuf, P. V.; Zielinski, D. C.; Yurkovich, J. T.; Johnsen, J.; Szubin, R.; Yang, L.; Kim, S. H.; Schulz, S.; Wu, M.; Dalldorf, C.; Ozdemir, E.; Palsson, B. O.; Feist, A.
10.1101/2021.07.19.452699 — bioengineering — Posted on 2021-07-20
1555 Genomic insights into the differentiated population admixture structure and demographic history of North East Asians
He, G.; Wang, M.; Zou, X.; Tang, R.; Yeh, H.-Y.; Wang, Z.; Yang, X.; Xia, Z.; Li, Y.; Guo, J.; Wang, R.; Liu, J.; Zhu, K.; Chen, J.; Yang, M.; Shen, Q.; Chen, J.; Zhao, J.; Ma, H.; Wei, L.; Chen, L.; Liu, C.; Liu, C.; Chen, G.; Hou, Y.; Wang, C.-C.
10.1101/2021.07.19.452943 — genomics — Posted on 2021-07-20
1558 High resolution dynamic mapping of the C. elegans intestinal brush border
Bidaud-Meynard, A.; Demouchy, F.; Nicolle, O.; Pacquelet, A.; Suman, S. K.; Plancke, C.; ROBIN, F. B.; Michaux, G.
10.1101/2021.06.14.448317 — developmental biology — Posted on 2021-07-20
1562 NOMA: a high-throughput microchip for robust, sequential measurements of secretions from the same single-cells
Liu, M.; Ji, Y.; Zhu, F.; Bai, X.; Li, L.; Xie, H.; Liu, X.; Luo, Y.; Liu, T.; Lin, B.; Lu, Y.
10.1101/2021.01.21.427049 — bioengineering — Posted on 2021-07-20
1564 Multi-regional module-based signal transmission in mouse visual cortex
Jia, X.; Siegle, J. H.; Durand, S.; Heller, G.; Ramirez, T.; Koch, C.; Olsen, S. R.
10.1101/2020.08.30.272948 — neuroscience — Posted on 2021-07-20
1565 Network expansion of genetic associations defines a pleiotropy map of human cell biology
Barrio-Hernandez, I.; Schwartzentruber, J.; Shrivastava, A.; del Toro, N.; Zhang, Q.; Bradley, G.; Hermjakob, H.; Orchard, S.; Dunham, I.; Anderson, C. A.; Porras, P.; Beltrao, P.
10.1101/2021.07.19.452924 — genetics — Posted on 2021-07-19
1566 Mitochondrial Respiratory Chain Protein Co-Regulation in the Human Brain
Trumpff, C.; Owusu-Ansah, E.; Klein, H.-U.; Lee, A.; Petyuk, V.; Wingo, T. S.; Wingo, A.; Thambisetty, M.; Ferrucci, L.; Seyfried, N.; Bennett, D. A.; De Jager, P. L.; Picard, M.
10.1101/2021.07.19.452923 — cell biology — Posted on 2021-07-19
1567 The amplitude of fNIRS hemodynamic response in the visual cortex unmasks autistic traits in typically developing children
Mazziotti, R. M.; Scaffei, E.; Conti, E.; Marchi, V.; Rizzi, R.; Battini, R.; Cioni, G.; Baroncelli, L.
10.1101/2021.07.19.452678 — neuroscience — Posted on 2021-07-19
1572 Evaluation of DNA extraction protocols from liquid-based cytology specimens for studying cervical microbiota
Shibata, T.; Nakagawa, M.; Coleman, H. N.; Owens, S. M.; Greenfield, W. W.; Sasagawa, T.; Robeson, M. S.
10.1101/2020.01.27.921619 — microbiology — Posted on 2021-07-19
1580 SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization
Wang, H.; Huang, P.; Deng, W.; Bao, H.; Lin, Z.; Liu, M.; Wu, J.; Zhou, X.; Qiao, M.; Yang, Y.; Cai, H.; Rao, F.; Chen, J.; Chen, D.; Lu, J.; Qin, A.; Kong, S.
10.1101/2021.07.19.452960 — physiology — Posted on 2021-07-19
1581 A novel nanoluciferase transgenic reporter to measure proteinuria in zebrafish
Naylor, R. W. W.; Lemarie, E.; Jackson-Crawford, A.; Davenport, J. B.; Mironov, A.; Lowe, M.; Lennon, R.
10.1101/2021.07.19.452884 — pathology — Posted on 2021-07-19
1584 Comparison of linear combination modeling strategies for GABA-edited MRS at 3T
Zöllner, H. J.; Tapper, S.; Hui, S. C. N.; Barker, P. B.; Edden, R. A. E.; Oeltzschner, G.
10.1101/2021.05.26.445817 — biochemistry — Posted on 2021-07-19
1585 Complete genomic and epigenetic maps of human centromeres
Altemose, N.; Logsdon, G. A.; Bzikadze, A. V.; Sidhwani, P.; Langley, S. A.; Caldas, G. V.; Hoyt, S. J.; Uralsky, L.; Ryabov, F. D.; Shew, C. J.; Sauria, M. E. G.; Borchers, M.; Gershman, A.; Mikheenko, A.; Shepelev, V. A.; Dvorkina, T.; Kunyavskaya, O.; Vollger, M. R.; Rhie, A.; McCartney, A. M.; Asri, M.; Lorig-Roach, R.; Shafin, K.; Aganezov, S.; Olson, D.; Gomes de Lima, L.; Potapova, T.; Hartley, G. A.; Haukness, M.; Kerpedjiev, P.; Gusev, F.; Tigyi, K.; Brooks, S.; Young, A.; Nurk, S.; Koren, S.; Salama, S. R.; Paten, B.; Rogaev, E. I.; Streets, A.; Karpen, G. H.; Dernburg, A. F.; Sulliv
10.1101/2021.07.12.452052 — genomics — Posted on 2021-07-19
1588 A high-throughput assay for directly monitoring nucleolar rRNA biogenesis
Bryant, C. J.; McCool, M. A.; Abriola, L.; Surovtseva, Y. V.; Baserga, S. J.
10.1101/2021.07.19.452935 — cell biology — Posted on 2021-07-19
1589 Live-cell 3D single-molecule tracking reveals how NuRD modulates enhancer dynamics
Basu, S.; Shukron, O.; Hall, D.; Parruto, P.; Ponjavic, A.; Shah, D.; Boucher, W.; Lando, D.; Zhang, W.; Reynolds, N.; Sober, L. H.; Jartseva, A.; Ragheb, R.; Ma, X.; Cramard, J.; Floyd, R.; Brown, G.; Balmer, J.; Drury, T. A.; Carr, A.; Needham, L.-M.; Aubert, A.; Communie, G.; Gor, K.; Steindel, M.; Morey, L.; Blanco, E.; Bartke, T.; Di Croce, L.; Berger, I.; Schaffitzel, C.; Lee, S.; Stevens, T. J.; Klenerman, D.; Hendrich, B.; Holcman, D.; Laue, E. D.
10.1101/2020.04.03.003178 — cell biology — Posted on 2021-07-19
1592 Longitudinal tracking reveals sustained polyclonal repopulation of human-HSPC in humanized mice despite vector integration bias
Suryawanshi, G. W.; Arokium, H.; Kim, S.; Khamaikawin, W.; Lin, S.; Shimizu, S.; Chupradit, K.; Lee, Y.; Xie, Y.; Guan, X.; Suryawanshi, V.; Presson, A. P.; An, D.-S.; Chen, I. S. Y.
10.1101/2020.08.21.261537 — molecular biology — Posted on 2021-07-19
1594 Structural model of PORCN illuminates disease-associated variants and drug binding sites
Yu, J.; Liao, P.-J.; Xu, W.; Jones, J. R.; Everman, D. B.; Flanagan-Steet, H.; Keller, T. H.; Virshup, D. M.
10.1101/2021.07.19.452875 — molecular biology — Posted on 2021-07-19
1595 Key substitutions in the spike protein of SARS-CoV-2 variants can predict resistance to monoclonal antibodies, but other substitutions can modify the effects
Lusvarghi, S.; Wang, W.; Herrup, R.; Neerukonda, S. N.; Vassell, R.; Bentley, L.; Eakin, A. E.; Erlandson, K. J.; Weiss, C. D.
10.1101/2021.07.16.452748 — microbiology — Posted on 2021-07-19
1601 The vesicular release probability sets the strength of individual Schaffer collateral synapses
Duerst, C. D.; Wiegert, J. S.; Schulze, C.; Helassa, N.; Torok, K.; Oertner, T. G.
10.1101/2020.08.02.232850 — neuroscience — Posted on 2021-07-19
1605 Cellular and behavioral effects of altered NaV1.2 sodium channel ion permeability in Scn2aK1422E mice
Echevarria-Cooper, D. M.; Hawkins, N. A.; Misra, S. N.; Huffman, A.; Thaxton, T.; Thompson, C. H.; Ben-Shalom, R.; Nelson, A. D.; Lipkin, A. M.; George, A. L.; Bender, K. J.; Kearney, J. A.
10.1101/2021.07.19.452930 — neuroscience — Posted on 2021-07-19
1606 Autophagic signaling promotes systems-wide remodeling in skeletal muscle upon oncometabolic stress
Karlstaedt, A.; Vitrac, H.; Salazar, R. L.; Gould, B. D.; Soedkamp, D.; Spivia, W.; Raedschelders, K.; Dinh, A. Q.; Guzman, A.; Tan, L.; Azinas, S.; Taylor, D. J. R.; Schiffer, W.; McNavish, D.; Burks, H. B.; Gottlieb, R. A.; Lorenzi, P. L.; Hanson, B.; Van Eyk, J. E.; Taegtmeyer, H.
10.1101/2020.10.13.338202 — systems biology — Posted on 2021-07-19
1608 Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance
Skovso, S.; Panzhinskiy, E.; Kolic, J.; Cen, H. H.; Dionne, D. A.; Dai, X.-Q.; Sharma, R. B.; Elghazi, L.; Ellis, C. E.; Faulkner, K.; Marcil, S. A. M.; Overby, P.; Noursadeghi, N.; Hutchinson, D.; Hu, X.; Modi, H.; Wildi, J.; Botezelli, J. D.; Noh, H. L.; Suk, S.; Gablaski, B.; Bautista, A.; Kim, R.; Cras-Meneur, C.; Flibotte, S.; Sinha, S.; Luciani, D. S.; Nislow, C.; Rideout, E. J.; Cytrynbaum, E. N.; Kim, J.; Bernal-Mizrachi, E.; Alonso, L. C.; MacDonald, P. E.; Johnson, J. D.
10.1101/2020.10.15.338160 — physiology — Posted on 2021-07-19
1609 OSTEOPONTIN DEFICIENCY LEADS TO THE RESOLUTION OF PROSTATIC FIBROSIS AND INFLAMMATION
Popovics, P.; Jain, A.; Skalitzky, K. O.; Schroeder, E.; Ruetten, H. M.; Cadena, M.; Uchtmann, K. S.; Vezina, C. M.; Ricke, W. A.
10.1101/2021.07.19.452973 — pathology — Posted on 2021-07-19
1612 Loss of the H4 lysine methyltransferase KMT5B drives tumorigenic phenotypes by depleting H3K27me3 at loci otherwise retained in H3K27M mutant DIPG cells
Kessler, K.; Mackay, A.; Grabovska, Y.; Molinari, V.; Burford, A.; Temelso, S.; Tari, H.; Yara-Romero, E.; Liu, I.; Yu, L.; Castel, D.; Choudhary, J.; Sottoriva, A.; Filbin, M.; Vinci, M.; Jones, C.
10.1101/2021.07.19.452493 — cancer biology — Posted on 2021-07-19
1615 Genetic demultiplexing of pooled single-cell RNA-sequencing samples in cancer facilitates effective experimental design
Weber, L. M.; Hippen, A. A.; Hickey, P. F.; Berrett, K. C.; Gertz, J.; Doherty, J. A.; Greene, C. S.; Hicks, S. C.
10.1101/2020.11.06.371963 — bioinformatics — Posted on 2021-07-19
1616 Optimal balancing of clinical factors in large scale clinical RNA-Seq studies
CHIANG, A. W. T.; Gazestani, V. H.; Altieri, M. G.; Kellman, B. P.; Nalabolu, S. P.; Pramparo, T.; Pierce, K.; Courchesne, E.; Lewis, N. E.
10.1101/2021.06.30.450639 — bioinformatics — Posted on 2021-07-19
1618 AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation
Lu, W.-C.; Omari, R.; Ray, H.; Williams, I.; Jacobs, C.; Hockaden, N.; Bochman, M. L.; Carpenter, R. L.
10.1101/2020.08.31.275909 — biochemistry — Posted on 2021-07-19
1624 Single-nucleus cross-tissue molecular reference maps to decipher disease gene function
Eraslan, G.; Drokhlyansky, E.; Anand, S.; Subramanian, A.; Fiskin, E.; Slyper, M.; Wang, J.; Van Wittenberghe, N.; Rouhana, J. M.; Waldman, J.; Ashenberg, O.; Dionne, D.; Win, T. S.; Cuoco, M. S.; Kuksenko, O.; Branton, P. A.; Marshall, J. L.; Greka, A.; Getz, G.; Segre, A. V.; Aguet, F.; Rozenblatt-Rosen, O.; Ardlie, K. G.; Regev, A.
10.1101/2021.07.19.452954 — cell biology — Posted on 2021-07-19
1628 Rosin Soap Exhibits Virucidal Activity
Bell, S.; Fairley, D. J.; Kettunen, H.; Vuorenmaa, J.; Orte, J.; Bamford, C. G. G.; McGrath, J.
10.1101/2021.07.19.452918 — microbiology — Posted on 2021-07-19
1630 Comparison of Neutralizing Antibody Titers Elicited by mRNA and Adenoviral Vector Vaccine against SARS-CoV-2 Variants
Tada, T.; Zhou, H.; Samanovic, M. I.; Dcosta, B. M.; Cornelius, A.; Mulligan, M. J.; Landau, N. R.
10.1101/2021.07.19.452771 — immunology — Posted on 2021-07-19
1631 TGF--dependent Lymphoid Tissue Residency of Stem-like T cells Limits the Response to Tumor Vaccine
Li, G.; Wang, L.; Ma, C.; Liao, W.; Liu, Y.; Mishra, S.; Zhang, X.; Qiu, Y.; Lu, Q.; Zhang, N.
10.1101/2021.07.19.452945 — immunology — Posted on 2021-07-19
1632 Single-dose respiratory mucosal delivery of next-generation viral-vectored COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2
Afkhami, S.; D'Agostino, M. R.; Zhang, A.; Stacey, H. D.; Marzok, A.; Kang, A.; Singh, R.; Bavananthasivam, J.; Ye, G.; Luo, X.; Wang, F.; Ang, J. C.; Zganiacz, A.; Sankar, U.; Kazhdan, N.; Koenig, J. F. E.; Phelps, A.; Jordana, M.; Wan, Y.; Mossman, K. L.; Jeyanathan, M.; Gillgrass, A.; Medina, M. F. C.; Smaill, F.; Lichty, B. D.; Miller, M. S.; Xing, Z.
10.1101/2021.07.16.452721 — immunology — Posted on 2021-07-19
1634 Unveiling Mutation Effects on the Structural Dynamics of the Main Protease from SARS-CoV-2 with Hybrid Simulation Methods
Philot, E. A.; Gasparini, P.; de Mattos, J. C.; Magro, A.; Torres-Bonfim, E.; Quiroz, R. C. N.; Klioussof, A.; Perahia, D.; Scott, A. L. B.
10.1101/2021.07.17.452787 — biophysics — Posted on 2021-07-19
1635 Artificial Intelligence-rationalized balanced PPARα/γ dual agonism resets the dysregulated macrophage processes in inflammatory bowel disease
Katkar, G.; Sayed, I. M.; Amandachar, M.; Castillo, V.; Vidales, E.; Toobian, D.; Usmani, F. F.; Sawires, J. R.; Leriche, G.; Yang, J.; Sandborn, W. J.; Das, S.; Sahoo, D.; Ghosh, P.
10.1101/2021.07.18.452807 — bioinformatics — Posted on 2021-07-19
1638 Real-time genomic surveillance during the 2021 re-emergence of the yellow fever virus in Rio Grande do Sul State, Brazil
Andrade, M. d. S.; Campos, F. S.; Campos, A. A. S.; Abreu, F. V. S. d.; Melo, F. L.; Cardoso, J. d. C.; Santos, E. d.; Born, L. C.; Silva, C. M. D. d.; Muller, N. F. D.; Oliveira, C. H. d.; Silva, A. J. J. d.; Simonini-Teixeira, D.; Bernal-Valle, S.; Mares-Guia, M. A.; Albuquerque, G. R.; Seva, A. d. P.; Romano, A. P. M.; Franco, A. C.; Ribeiro, B. M.; Roehe, P. M.; Almeida, M. A. B. d.
10.1101/2021.07.16.452727 — genomics — Posted on 2021-07-19
1642 A nationwide genomic study of clinical Klebsiella pneumoniae in Norway 2001-2015: Introduction and spread of ESBL facilitated by CG15 and CG307
Fostervold, A.; Hetland, M. A. K.; Bakksjo, R.-J.; Bernhoff, E.; Holt, K.; Samuelsen, O.; Simonsen, G. S.; Sundsfjord, A.; Wyres, K. L.; Lohr, I. H.; The Norwegian Study Group on Klebsiella pneumoniae,
10.1101/2021.07.16.452602 — microbiology — Posted on 2021-07-19
1643 Susceptibilities of human ACE2 genetic variants in coronavirus infection
Ren, W.; Zhu, Y.; Lan, J.; Chen, H.; Wang, Y.; Shi, H.; Feng, F.; Chen, D.-Y.; Close, B.; Zhao, X.; Wu, J.; Tian, B.; Yuan, Z.; Zhou, D.; Saeed, M.; Wang, X.; Zhang, R.; Ding, Q.
10.1101/2021.07.18.452826 — microbiology — Posted on 2021-07-19
1645 One mucosal administration of a live attenuated recombinant COVID-19 vaccine protects non-human primates from SARS-CoV-2
Tioni, M. F.; Jordan, R.; Silva Pena, A.; Garg, A.; Wu, D.; Phan, S. I.; Cheng, X.; Greenhouse, J.; Orekov, T.; Valentin, D.; Kar, S.; Pessaint, L.; Andersen, H.; Stobart, C. C.; Bloodworth, M. H.; Peebles, R. S.; Liu, Y.; Xie, X.; Shi, P.-Y.; Moore, M. L.; Tang, R. S.
10.1101/2021.07.16.452733 — immunology — Posted on 2021-07-19
1646 A mosaic adeno-associated virus vector as a versatile tool that exhibits high levels of transgene expression and neuron specificity in primate brain
Kimura, K.; Nagai, Y.; Hatanaka, G.; Fang, Y.; Zheng, A.; Fujiwara, M.; Nakano, M.; Hori, Y.; Takeuchi, R.; Inagaki, M.; Minamimoto, T.; Fujita, I.; Inoue, K.-i.; Takada, M.
10.1101/2021.07.18.452859 — neuroscience — Posted on 2021-07-19
1647 Botrytis cinerea BcPTP1 is a late infection phase, cysteine rich protein cytotoxic effector
Zhu, W.; Yu, M.; Xu, R.; Bi, K.; Xiong, C.; Liu, Z.; Sharon, A.; Jiang, D.; Wu, M.; Gu, Q.; Gong, L.; Chen, W.; Wei, W.
10.1101/2021.07.18.452873 — pathology — Posted on 2021-07-19
1648 Phenotypic plasticity and genetic control in colorectal cancer evolution
Househam, J.; Heide, T.; Cresswell, G. D.; Lynn, C.; Spiteri, I.; Mossner, M.; Kimberley, C.; Gabbutt, C.; Lakatos, E.; Berner, A.; Schmidt, M.; Baker, A.-M.; Fernandez-Mateos, J.; Chen, B.; Zapata, L.; James, C.; Nichol, D.; Costa, H.; Mitchinson, M.; Jansen, M.; Caravagna, G.; Shibata, D.; Bridgewater, J.; Rodriguez-Justo, M.; Magnani, L.; Sottoriva, A.; Graham, T. A.
10.1101/2021.07.18.451272 — cancer biology — Posted on 2021-07-19
1649 ARF4-mediated Retrograde Trafficking Drives Chemoresistance in Glioblastoma
Budhiraja, S.; Baisiwala, S.; Perrault, E.; Cho, S.; Nandoliya, K.; Dara, G.; Zolp, A.; Chen, L.; Dmello, C.; Park, C.; Sonabend, A.; Ahmed, A.
10.1101/2021.07.18.451328 — cancer biology — Posted on 2021-07-19
1651 The genomic formation of Tanka people, an isolated 'Gypsies in water' in the coastal region of Southeast China
He, G. G.; Zhang, Y.; Wei, L.-H.; Wang, M.; Yang, X.; Guo, J.; Hu, R.; Wang, C.-C.; Zhang, X.-Q.
10.1101/2021.07.18.452867 — genetics — Posted on 2021-07-19
1652 Huntington's disease age at motor onset is modified by the tandem hexamer repeat in TCERG1
Lobanov, S. V.; McAllister, B.; McDade-Kumar, M.; Landwehrmeyer, G. B.; Rosser, A. E.; REGISTRY Investigators of the European Huntington's disease network, ; Paulsen, J. S.; PREDICT-HD Investigators of the Huntington Study Group, ; Lee, J.-M.; MacDonald, M. E.; Gusella, J.; Ryten, M.; Williams, N.; Holmans, P.; Massey, T. H.; Jones, L.
10.1101/2021.07.16.452643 — genetics — Posted on 2021-07-19
1654 ACE2 binding is an ancestral and evolvable trait of sarbecoviruses
Starr, T. N.; Zepeda, S. K.; Walls, A. C.; Greaney, A. J.; Veesler, D.; Bloom, J. D.
10.1101/2021.07.17.452804 — evolutionary biology — Posted on 2021-07-19
1655 Severe introduced predator impacts despite attempted functional eradication
Cheng, B. S.; Blumenthal, J.; Chang, A. L.; Barley, J.; Ferner, M. C.; Nielsen, K. J.; Ruiz, G. M.; Zabin, C. J.
10.1101/2021.07.19.451788 — ecology — Posted on 2021-07-19
1659 Vaccinia Virus Arrests and Shifts the Cell Cycle
Martin, C. K.; Samolej, J.; Olson, A. T.; Bertoli, C.; Wiebe, M. S.; de Bruin, R. A. M.; Mercer, J.
10.1101/2021.07.19.452625 — microbiology — Posted on 2021-07-19
1660 SARS-CoV-2 spike P681R mutation, a hallmark of the Delta variant, enhances viral fusogenicity and pathogenicity
Saito, A.; Irie, T.; Suzuki, R.; Maemura, T.; Nasser, H.; Uriu, K.; Kosugi, Y.; Shirakawa, K.; Sadamasu, K.; Kimura, I.; Ito, J.; Wu, J.; Iwatsuki-Horimoto, K.; Ito, M.; Yamayoshi, S.; Ozono, S.; Butlertanaka, E. P.; Tanaka, Y. L.; Shimizu, R.; Shimizu, K.; Yoshimatsu, K.; Kawabata, R.; Sakaguchi, T.; Tokunaga, K.; Yoshida, I.; Asakura, H.; Nagashima, M.; Kazuma, Y.; Nomura, R.; Horisawa, Y.; Yoshimura, K.; Takaori-Kondo, A.; Imai, M.; The Genotype to Phenotype Japan (G2P-Japan) Consortium, ; Nakagawa, S.; Ikeda, T.; Fukuhara, T.; Kawaoka, Y.; Sato, K.
10.1101/2021.06.17.448820 — microbiology — Posted on 2021-07-19
1662 Macrophages govern antiviral responses in human lung tissues protected from SARS-CoV-2 infection
Kenney, D. J.; O'Connell, A. K.; Turcinovic, J.; Montanaro, P.; Hekman, R. M.; Tamura, T.; Berneshawi, A. R.; Cafiero, T. R.; Al Abdullatif, S.; Blum, B.; Goldstein, S. I.; Heller, B.; Gertje, H. P.; Bullitt, E.; Trachtenberg, A. J.; Chavez, E.; Sheikh, A.; Kurnick, S.; Grosz, K.; Bosmann, M.; Ericsson, M.; Huber, B. R.; Saeed, M.; Balazs, A. B.; Francis, K. P.; Klose, A.; Paragas, N.; Campbell, J. D.; Connor, J. H.; Emili, A.; Crossland, N. A.; Ploss, A.; Douam, F.
10.1101/2021.07.17.452554 — microbiology — Posted on 2021-07-19
1666 Auxin and pectin remodeling interplay during rootlet emergence in white lupin
Jobert, F.; Soriano, A.; Brottier, L.; Casset, C.; Divol, F.; Safran, J.; LEFEBVRE, V.; PELLOUX, J.; Robert, S.; PERET, B.
10.1101/2021.07.19.452882 — plant biology — Posted on 2021-07-19
1669 ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1
Aykul, S.; Huang, L.; Wang, L.; Das, N.; Reisman, S.; Ray, Y.; Zhang, Q.; Rothman, N.; Nannuru, K. C.; Kamat, V.; Brydges, S.; Troncone, L.; Johnsen, L.; Yu, P. B.; Lees-Shepard, J.; Schutz, K.; Murphy, A. J.; Economides, A. N.; Idone, V.; Hatsell, S. J.
10.1101/2021.07.18.452865 — biochemistry — Posted on 2021-07-19
1673 Facultative variation across a shallow to deep torpor spectrum in hummingbirds
Shankar, A.; Cisneros, I. N.; Thompson, S.; Graham, C. H.; Powers, D. R.
10.1101/2021.07.18.452827 — ecology — Posted on 2021-07-19
1674 A cannabinoid receptor agonist shows anti-inflammatory and survival properties in human SARS-CoV-2-infected iPSC-derived cardiomyocytes
Aragao, L. G. H. S.; Oliveira, J. T.; Temerozo, J. R.; Mendes, M. A.; Salerno, J. A.; Pedrosa, C. d. S. G.; Puig-Pijuan, T.; Verissimo, C.; Ornelas, I. M.; Torquato, T.; Vitoria, G.; Sacramento, C. Q.; Fintelman-Rodrigues, N.; Dias, S. d. S. G.; Cardoso Soares, V.; Souza, L. R. Q.; Karmirian, K.; Goto-Silva, L.; Biagi, D.; Cruvinel, E. M.; Dariolli, R.; Furtado, D. R.; Bozza, P. T.; Borges, H. L.; Souza, T. M. L.; Guimaraes, M. Z. P.; Rehen, S.
10.1101/2021.02.20.431855 — cell biology — Posted on 2021-07-19
1675 CLARA: A web portal for interactive exploration of the cardiovascular cellular landscape in health and disease
Dona, M. S. I.; Hsu, I.; Rathnayake, T. S.; Farrugia, G. E.; Gaynor, T. L.; Kharbanda, M.; Skelly, D. A.; Pinto, A. R.
10.1101/2021.07.18.452862 — cell biology — Posted on 2021-07-19
1677 Altered cortical processing of sensory input in Huntington disease mouse models
Sepers, M. D.; Mackay, J. P.; Koch, E.; Xiao, D.; Mohajerani, M. H.; Chan, A. W.; Smith-Dijak, A. I.; Ramandi, D.; Murphy, T. H.; Raymond, L. A.
10.1101/2021.07.18.452688 — neuroscience — Posted on 2021-07-19
1679 FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons
Hale, C. R.; Sawicka, K.; Mora, K.; Fak, J. J.; Kang, J. J.; Cutrim, P.; Cialowicz, K.; Carroll, T.; B. Darnell, R.
10.1101/2021.07.18.452839 — neuroscience — Posted on 2021-07-19
1680 Common molecular mechanisms underlie the transfer of alpha-synuclein, Tau and huntingtin and modulate spontaneous activity in neuronal cells
Bras, I. C.; Khani, M. H.; Vasili, E.; Mobius, W.; Riedel, D.; Parfentev, I.; Gerhardt, E.; Fahlbusch, C.; Urlaub, H.; Zweckstetter, M.; Gollisch, T.; Outeiro, T. F.
10.1101/2021.07.18.452825 — neuroscience — Posted on 2021-07-19
1683 CoLoRd: Compressing long reads
Kokot, M.; Gudys, A.; Li, H.; Deorowicz, S.
10.1101/2021.07.17.452767 — bioinformatics — Posted on 2021-07-19
1689 Isotropic Reconstruction of Electron Tomograms with Deep Learning
Liu, Y.-T.; Zhang, H.; Wang, H.; Tao, C.-L.; Bi, G.-Q.; Zhou, Z. H.
10.1101/2021.07.17.452128 — cell biology — Posted on 2021-07-19
1690 Decoding molecular and cellular heterogeneity of nucleus accumbens with high-throughput scRNA-seq and MERFISH
Chen, R.; Blosser, T. R.; Djekidel, M. N.; Hao, J.; Bhattacherjee, A.; Chen, W.; Tuesta, L. M.; Zhuang, X.; Zhang, Y.
10.1101/2021.07.17.452808 — neuroscience — Posted on 2021-07-19
1693 Lane-maze for preference testing in flies
Eckert, F. B.; Valdati, D. d. B.; Marino-Neto, J.; de Toni, D. C.; Lino de Oliveira, C.
10.1101/2021.07.18.452790 — neuroscience — Posted on 2021-07-19
1697 HAMdetector: A Bayesian regression model that integrates information to detect HLA-associated mutations
Habermann, D.; Karimzadeh, H.; Walker, A.; Li, Y.; Yang, R.; Brumme, Z. L.; Timm, J.; Roggendorf, M.; Hoffmann, D.
10.1101/2021.07.17.452375 — bioinformatics — Posted on 2021-07-19
1700 Discovering cellular programs of intrinsic and extrinsic drivers of metabolic traits using LipocyteProfiler
Strobel, S.; Laber, S.; Mercader, J. M.; Dashti, H.; Ainbinder, A.; Honecker, J.; Garborcauskas, G.; Stirling, D. R.; Leong, A.; Figueroa, K.; Sinnott-Armstrong, N.; Kost-Alimova, M.; Deodato, G.; Harney, A.; Way, G. P.; Saadat, A.; Harken, S.; Reibe-Pal, S.; Ebert, H.; Zhang, Y.; Calabuig, V.; McGonagle, E.; Stefek, A.; Dupuis, J.; Cimini, B.; Hauner, H.; Udler, M. S.; Carpenter, A. E.; Florez, J. C.; Lindgren, C. M.; Jacobs, S. B.; Claussnitzer, M.
10.1101/2021.07.17.452050 — genomics — Posted on 2021-07-19
1705 Echidna: integrated simulations of single-cell immune receptor repertoires and transcriptomes
Han, J.; Kuhn, R.; Papadopoulou, C.; Agrafiotis, A.; Kreiner, V.; Shlesinger, D.; Dizerens, R.; Hong, K.-L.; Weber, C.; Greiff, V.; Oxenius, A.; Reddy, S. T.; Yermanos, A.
10.1101/2021.07.17.452792 — immunology — Posted on 2021-07-19
1706 Axial spondyloarthritis patients have altered mucosal IgA response to oral and fecal microbiota
Gill, T.; Stauffer, P.; Asquith, M.; Laderas, T.; Martin, T. M.; Davin, S.; Schleisman, M.; Ramirez, C.; Ogle, K.; Lindquist, I.; Nguyen, J.; Planck, S. R.; Shaut, C.; Diamond, S.; Rosenbaum, J. T.; Karstens, L.
10.1101/2021.07.15.452558 — immunology — Posted on 2021-07-19
1711 Selenium in wheat from farming to food
Wang, M.; Li, B.; Li, S.; Kong, F.; Zhang, X.
10.1101/2021.07.17.452805 — plant biology — Posted on 2021-07-19
1716 SprayNPray: user-friendly taxonomic profiling of genome and metagenome contigs
Garber, A. I.; Armbruster, C. R.; Lee, S. E.; Cooper, V. S.; Bomberger, J. M.; McAllister, S. M.
10.1101/2021.07.17.452725 — bioinformatics — Posted on 2021-07-19
1717 A comparative in vitro and in vivo study of osteogenicity by using two biomaterials and two human mesenchymal stem cell subtypes
Fievet, L.; Serratrice, N.; Brulin, B.; Giraudo, L.; Veran, J.; Sabatier, F.; Degardin, N.; Feron, F.; Layrolle, P.
10.1101/2021.07.17.452782 — bioengineering — Posted on 2021-07-19
1718 The role of cytosolic polyadenylation element binding protein 2 alternative splicing in hypoxia
Mayo, E. M.; Stevens, S. C.; Ali, A. N.; Moss, C. J.; Lund, S. P.; Nazario-Munoz, G. S.; Permuth, J. B.; Westerheide, S. D.; Chalfant, C. E.; Park, M. A.
10.1101/2020.10.05.325290 — cell biology — Posted on 2021-07-19
1719 Dynamic mechanisms of CRISPR interference by Escherichia coli CRISPR-Cas3
Yoshimi, K.; TAKESHITA, K.; Kodera, N.; Shibumura, S.; Yamauchi, Y.; Omatsu, M.; Kunihiro, Y.; Yamamoto, M.; Mashimo, T.
10.1101/2021.07.18.452824 — molecular biology — Posted on 2021-07-19
1726 Using diffusion MRI data acquired with ultra-high gradients to improve tractography in routine-quality data
Maffei, C.; Lee, C.; Planich, M.; Ramprasad, M.; Ravi, N.; Trainor, D.; Urban, Z.; Kim, M.; Jones, R.; Henin, A.; Hofmann, S.; Pizzagalli, D.; Auerbach, R.; Gabrieli, J.; Whitfield-Gabrieli, S.; Greve, D.; Haber, S.; Yendiki, A.
10.1101/2021.06.28.450265 — neuroscience — Posted on 2021-07-19
1729 In vivo visualization of propagating α-synuclein pathologies in mouse and marmoset models by a bimodal imaging probe, C05-05
Ono, M.; Takahashi, M.; Shimozawa, A.; Fujinaga, M.; Mori, W.; Nagai, Y.; Mimura, K.; Kumata, K.; Kikuchi, T.; Shimojo, M.; Takuwa, H.; Minamihisamatsu, T.; Uchida, S.; Mishra, S. K.; Yamaguchi, Y.; Shimizu, H.; Kakita, A.; Endo, H.; Takado, Y.; Minamimoto, T.; Sahara, N.; Zhang, M.-R.; Hasegawa, M.; Higuchi, M.
10.1101/2020.10.23.349860 — neuroscience — Posted on 2021-07-19
1731 Revision of the genus Dichaetophora Duda (Diptera: Drosophilidae), part I: DNA bar-coding and molecular phylogenetic reconstruction
Katoh, T. K.; Chen, J.-M.; Yang, J.-H.; Zhang, G.; Wang, L.; Suwito, A.; Toda, M. J.; Zhang, Y.-P.; Gao, J.-J.
10.1101/2021.05.28.446102 — zoology — Posted on 2021-07-19
1733 Regional cytoarchitecture of the adult and developing mouse enteric nervous system
Hamnett, R.; Dershowitz, L. B.; Sampathkumar, V.; Wang, Z.; De Andrade, V.; Kasthuri, N.; Druckmann, S.; Kaltschmidt, J. A.
10.1101/2021.07.16.452735 — neuroscience — Posted on 2021-07-18
1734 3D molecular phenotyping of cleared human brain tissues with light-sheet fluorescence microscopy
Pesce, L.; Scardigli, M.; Gavryusev, V.; Laurino, A.; Mazzamuto, G.; Sancataldo, G.; Silvestri, L.; Destrieux, C.; R. Hof, P.; Costantini, I.; Pavone, F.
10.1101/2021.07.18.452829 — neuroscience — Posted on 2021-07-18
1735 Spatio-temporal dynamics of stress-induced network reconfigurations reflect negative affectivity
Kuehnel, A.; Czisch, M.; Saemann, P. G.; BeCome Study Team, ; Binder, E. B.; Kroemer, N. B.
10.1101/2021.07.16.452622 — neuroscience — Posted on 2021-07-18
1736 Probing the toxic interactions between the reactive dye Drimaren Red and Human Serum Albumin
Menezes, T. M.; de Assis, C. R. D.; da Silva Neto, A. M.; Gubert, P.; Ghislandi, M. G.; Neves, J. L.
10.1101/2021.07.17.452798 — biophysics — Posted on 2021-07-18
1737 Finding Overlapping Rmaps via Gaussian Mixture Model Clustering
Mukherjee, K.; Rossi, M.; Dole-Muinos, D.; Ajayi, A.; Prosperi, M.; Boucher, C.
10.1101/2021.07.16.452722 — bioinformatics — Posted on 2021-07-18
1738 Merfin: improved variant filtering and polishing via k-mer validation
Formenti, G.; Rhie, A.; Walenz, B. P.; Thibaud-Nissen, F.; Shafin, K.; Koren, S.; Myers, E. W.; Jarvis, E. D.; Phillippy, A. M.
10.1101/2021.07.16.452324 — bioinformatics — Posted on 2021-07-18
1741 Body size mediates latitudinal population differences in response to Bd infection in two amphibian species.
Meurling, S.; Cortazar-Chinarro, M.; Siljestam, M.; Ahlen, D.; Agren, E.; Hoglund, J.; Laurila, A.
10.1101/2021.07.16.452656 — ecology — Posted on 2021-07-18
1743 TAF4b transcription networks regulating early oocyte differentiation
Gura, M. A.; Relovska, S.; Abt, K. M.; Seymour, K. A.; Wu, T.; Kaya, H.; Turner, J.; Fazzio, T. G.; Freiman, R. N.
10.1101/2021.07.18.452838 — developmental biology — Posted on 2021-07-18
1745 LENG8 regulation of mRNA processing, is responsible for the control of mitochondrial activity
Zhao, Y.; Wang, X.; Li, N.; Liu, Y.; Sun, Z.; Wang, S.; Gao, Z.; Zhang, X.; Mao, L.; Tang, R.; Xue, W.; Li, C.; Guan, J.; Yi, H.; Zhang, N.; Ding, Q.; Liu, F.
10.1101/2021.07.17.452750 — cell biology — Posted on 2021-07-18
1746 Dynamic surveillance of mosquitoes and their viromes in Wuhan during 2020.
Ren, N.; Wang, S.; Shi, C.; Yu, P.; Zhao, L.; Huang, D.; Ma, H.; Xiao, S.; Wang, F.; Yuan, Z.; Xia, H.
10.1101/2021.07.17.452774 — microbiology — Posted on 2021-07-18
1749 Chloride oscillation in pacemaker neurons regulates circadian rhythms through a chloride-sensing WNK kinase signaling cascade
Schellinger, J. N.; Sun, Q.; Pleinis, J. M.; An, S.-W.; Hu, J.; Mercenne, G.; Titos, I.; Huang, C.-L.; Rothenfluh, A.; Rodan, A. R.
10.1101/2021.07.16.452737 — neuroscience — Posted on 2021-07-18
1753 Deep neural language modeling enables functional protein generation across families
Madani, A.; Krause, B.; Greene, E. R.; Subramanian, S.; Mohr, B. P.; Holton, J. M.; Olmos, J. L.; Xiong, C.; Sun, Z. Z.; Socher, R.; Fraser, J. S.; Naik, N.
10.1101/2021.07.18.452833 — synthetic biology — Posted on 2021-07-18
1754 The low and high postpubertal ethanol use: long-term effects on drinkers reproductive parameters and ethanol-naive offspring development
Fioravante, V. C.; Godoi, A. R.; Camargo, V. M. d. B.; Pinheiro, P. F. F.; Padovani, C. R.; Martinez, M.; Martinez, F. E.
10.1101/2021.07.16.452713 — pharmacology and toxicology — Posted on 2021-07-18
1755 Autofluorescence microscopy as a label-free tool for renal histology and glomerular segmentation
Patterson, N. H.; Neumann, E. K.; Sharman, K.; Allen, J. L.; Harris, R. C.; Fogo, A. B.; deCaestecker, M. P.; Caprioli, R. M.; Van de Plas, R.; Spraggins, J. M.
10.1101/2021.07.16.452703 — bioinformatics — Posted on 2021-07-18
1756 Specificity of Loxosceles α clade phospholipase D enzymes for choline-containing lipids: role of a conserved aromatic cage
Moutoussamy, E. E.; Waheed, Q.; Binford, G. J.; Khan, H. M.; Moran, S. M.; Eitel, A. R.; Cordes, M. H. J.; Reuter, N.
10.1101/2021.07.16.452673 — bioinformatics — Posted on 2021-07-18
1757 Amplification-free detection of viral RNA by super resolution imaging-based CRISPR/Cas13a System
Qin, P.; Yu, D.; He, Q.; Chen, Q.; Li, F.; Yuan, X.; Liu, C.; Deng, L.; Zhang, Y. b.; Du, K.; Dong, Y.; Pandey, V.; Xu, L.; Zhong, X.; Wei, J.
10.1101/2021.07.17.452803 — bioengineering — Posted on 2021-07-18
1758 Genome-Wide Detection of Imprinted Differentially Methylated Regions Using Nanopore Sequencing
Akbari, V.; Garant, J.-M.; O'Neill, K.; Pandoh, P.; Moore, R.; Marra, M. A.; Hirst, M.; Jones, S. J.
10.1101/2021.07.17.452734 — genomics — Posted on 2021-07-18
1759 Genome size evolution in the diverse insect order Trichoptera
Heckenhauer, J.; Frandsen, P. B.; Sproul, J. S.; Li, Z.; Paule, J.; Larracuente, A. M.; Maughan, P. J.; Barker, M. S.; Schneider, J. V.; Stewart, R. J.; Pauls, S. U.
10.1101/2021.05.10.443368 — evolutionary biology — Posted on 2021-07-18
1762 Knockout of E-cadherin in adult mouse epithelium results in emphysema and airway disease
Ghosh, B.; Loube, J.; Thapa, S.; Capodanno, E.; Mahmud, S.; Girgis, M.; Chen, S.; Nishida, K.; Ying, L.; Swaby, C.; Wally, A.; Bhowmik, D. R.; Zaykaner, M. E.; Mitzner, W.; Sidhaye, V. K.
10.1101/2021.07.18.452342 — cell biology — Posted on 2021-07-18
1765 Oct1 recruits the histone lysine demethylase Utx to canalize lineage specification
Perovanovic, J.; Wu, Y.; Shen, Z.; Hughes, E.; Chandrasekharan, M. B.; Tantin, D.
10.1101/2020.12.01.406488 — developmental biology — Posted on 2021-07-18
1769 Defining the Sensitivity Landscape of 74,389 EGFR Variants to Tyrosine Kinase Inhibitors
An, L.; Chen, S.; Wu, G.; Liu, C.; Wang, Z.; Wang, C.; Shi, Z.; Niu, C.; Li, X.; Tang, W.; Xu, H.; Wang, Y.
10.1101/2021.07.18.452818 — genetics — Posted on 2021-07-18
1770 Co-variation between glucocorticoids, behaviour and immunity supports the pace-of-life syndrome hypothesis: an experimental approach
Carbillet, J.; Rey, B.; Palme, R.; Monestier, C.; Borger, L.; Lavabre, T.; Maublanc, M.-L.; Cebe, N.; Rames, J.-L.; Le Loc'h, G.; Wasniewski, M.; Rannou, B.; Gilot-Fromont, E.; Verheyden, H.
10.1101/2021.03.13.435238 — evolutionary biology — Posted on 2021-07-18
1771 Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction
Peng, H.; Shindo, K.; Donahue, R. R.; Gao, E.; Ahern, B. M.; Levitan, B. M.; Tripathi, H.; Powell, D.; Noor, A.; Satin, J.; Seifert, A. W.; Abdel-Latif, A.
10.1101/2020.09.29.317388 — developmental biology — Posted on 2021-07-18
1772 Longitudinal Auditory Pathophysiology Following Mild Blast Induced Trauma
Han, E. X.; Fernandez, J. M.; Swanberg, C.; Shi, R.; Bartlett, E. L.
10.1101/2020.11.06.371591 — neuroscience — Posted on 2021-07-18
1775 Design considerations for workflow management systems use in production genomics research and the clinic
Ahmed, A. E.; Allen, J.; Bhat, T.; Burra, P.; Fliege, C. E.; Hart, S. N.; Heldenbrand, J. R.; Hudson, M. E.; Istanto, D. D.; Kalmbach, M. T.; Kapraun, G. D.; Kendig, K. I.; Kendzior, M. C.; Klee, E. W.; Mattson, N.; Ross, C. A.; Sharif, S. M.; Venkatakrishnan, R.; Fadlelmola, F. M.; Mainzer, L. S.
10.1101/2021.04.03.437906 — bioinformatics — Posted on 2021-07-18
1777 Dual effects of presynaptic membrane mimetics on α-synuclein amyloid aggregation
Lin, Y.; Ito, D.; Yoo, J. M.; Lim, M. H.; Yu, W. K.; Kawata, Y.; Lee, Y.-H.
10.1101/2021.07.13.452016 — biophysics — Posted on 2021-07-18
1779 The interplay of wind and uplift facilitates over-water flight in facultative soaring birds
Nourani, E.; Bohrer, G.; Becciu, P.; Bierregaard, R. O.; Duriez, O.; Figuerola, J.; Gangoso, L.; Giokas, S.; Higuchi, H.; Kassara, C.; Kulikova, O.; Lecomte, N.; Monti, F.; Pokrovsky, I.; Sforzi, A.; Therrien, J.-F.; Tsiopelas, N.; Vansteelant, W. M. G.; Viana, D. S.; Yamaguchi, N. M.; Wikelski, M.; Safi, K.
10.1101/2020.09.04.282939 — animal behavior and cognition — Posted on 2021-07-18
1780 Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity
Melhem, H.; Kaya, B.; Kaymak, T.; Wuggenig, P.; Flint, E.; Roux, J.; Cavelti-Weder, C.; Balmer, M.; Walser, J.-C.; Morales, R.; Riedel, C.; Liberali, P.; Villablanca, E.; Niess, J.
10.1101/2021.03.27.437264 — immunology — Posted on 2021-07-18
1781 Room Temperature Isothermal Colorimetric Padlock Probe Rolling Circle Amplification for Viral RNA Detection
Huang, W.; Ting, J.; Fang, M.; Hsu, H.; Su, J.; Misaki, T.; Chan, D.; Yang, J.; Yeh, T.-Y.; Yang, K.; Chien, V.; Huang, T.; Chen, A.; Wei, C.; Hsu, J.; Clapper, J. C.
10.1101/2020.06.12.128876 — synthetic biology — Posted on 2021-07-17
1784 Novel Hendra virus variant detected by sentinel surveillance of Australian horses.
Annand, E. J.; Horsburgh, B. A.; Xu, K.; Reid, P. A.; Poole, B.; de Kantzow, M. C.; Brown, N.; Tweedie, A.; Michie, M.; Grewar, J. D.; Jackson, A. E.; Singanallur, N. B.; Plain, K. M.; Tachedjian, M.; van der Heide, B.; Williams, D. T.; Secombe, C.; Laing, E. D.; Sterling, S.; Yan, L.; Jackson, L.; Jones, C.; Plowright, R. K.; Peel, A. J.; Diallo, I.; Breed, A. C.; Broder, C. C.; Britton, P. N.; Dhand, N. K.; Smith, I.; Eden, J.-S.
10.1101/2021.07.16.452724 — molecular biology — Posted on 2021-07-18
1786 A strategy to suppress STAT1 signalling conserved in pathogenic poxviruses and paramyxoviruses
Talbot-Cooper, C.; Pantelejevs, T.; Shannon, J. P.; Cherry, C. R.; Au, M. T.; Hyvönen, M.; Hickman, H. D.; Smith, G. L.
10.1101/2021.07.17.452491 — microbiology — Posted on 2021-07-17
1788 Clonally expanded virus-specific CD8 T cells acquire diverse transcriptional phenotypes during acute, chronic, and latent infections
Kuhn, R.; Sandu, I.; Agrafiotis, A.; Hong, K.-L.; Neumeier, D.; Merkler, D.; Oxenius, A.; Reddy, S. T.; Yermanos, A.
10.1101/2021.06.29.450285 — immunology — Posted on 2021-07-17
1789 Degeneracy and stability in neural circuits of neuromodulators
Behera, C. K.; Joshi, A.; Wang, D.-H.; Sharp, T.; Wong-Lin, K.
10.1101/2020.09.25.313999 — neuroscience — Posted on 2021-07-17
1790 α-Synuclein facilitates clathrin assembly in synaptic vesicle endocytosis
Vargas, K. J.; Colosi, P. L.; Girardi, E.; Park, J.-M.; Chandra, S. S.
10.1101/2020.04.29.069344 — neuroscience — Posted on 2021-07-17
1791 Identification of phenotype-specific networks from paired gene expression-cell shape imaging data
Barker, C. G.; Petsalaki, E.; Giudice, G.; Sero, J.; Ekpenyong, E. N.; Bakal, C.; Petsalaki, E.
10.1101/2021.02.11.430597 — systems biology — Posted on 2021-07-17
1796 Novel Hendra virus variant detected by sentinel surveillance of Australian horses.
Annand, E. J.; Horsburgh, B. A.; Xu, K.; Reid, P. A.; Poole, B.; de Kantzow, M. C.; Brown, N.; Tweedie, A.; Michie, M.; Grewar, J. D.; Jackson, A. E.; Singanallur, N. B.; Plain, K. M.; Tachedjian, M.; van der Heide, B.; Williams, D. T.; Secombe, C.; Laing, E. D.; Sterling, S.; Yan, L.; Jackson, L.; Jones, C.; Plowright, R. K.; Peel, A. J.; Diallo, I.; Breed, A. C.; Broder, C. C.; Britton, P. N.; Dhand, N. K.; Smith, I.; Eden, J.-S.
10.1101/2021.07.16.452724 — molecular biology — Posted on 2021-07-17
1798 Proximity interactome analysis of Lassa polymerase reveals eRF3a/GSPT1 as a druggable target for host directed antivirals.
Fang, J.; Pietzsch, C.; Tsaprailis, G.; Crynen, G.; Cho, K. F.; Ting, A. Y.; Bukreyev, A.; Saphire, E. O.; de la Torre, J. C.
10.1101/2021.07.16.452739 — microbiology — Posted on 2021-07-17
1800 Deep deconvolution of the hematopoietic stem cell regulatory microenvironment reveals a high degree of specialization and conservation between mouse and human.
Ye, J.; Calvo, I. A.; Cenzano, I.; Vilas-Zornoza, A.; Martinez-de-Morentin, X.; Lasaga, M.; Alignani, D.; Pavia, B.; Vinado, A. C.; San Martin-Uriz, P.; Romero, J. P.; Quilez Agreda, D.; MinanaBarrios, M.; Sancho-Gonzalez, I.; Todisco, G.; Malcovati, L.; Planell, N.; Saez, B.; Tegner, J.; Prosper, F.; Gomez-Cabrero, D.
10.1101/2021.07.17.452614 — immunology — Posted on 2021-07-17
1801 TREM2 impacts brain microglia, oligodendrocytes and endothelial co-expression modules revealing genes and pathways important in Alzheimer s disease
Carbajosa, G.; Malki, K.; Lawless, N.; Wang, H.; Ryder, J. W.; Wood, K.; Mein, C. A.; Hodgkinson, A.; Dobson, R. J. B.; Collier, D. A.; ONeill, M.; Newhouse, S. J.; Hodges, A. K.
10.1101/2021.07.16.452732 — neuroscience — Posted on 2021-07-17
1805 microRNAs Over-expressed in Diabetic Foot Ulcers Healing - Computational Modeling of Molecular Structure
de Oliveira Andrade, L. J.; Vinhaes Bittencourt, A. M.; Matos de Oliveira, L.; Matos de Oliveira, G. C.
10.1101/2021.07.16.452675 — molecular biology — Posted on 2021-07-17
1806 Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma
Lu, X.; Sabbasani, V. R.; Osei-Amponsa, V.; Evans, C. N.; King, J. C.; Tarasov, S. G.; Dyba, M.; Chan, K. C.; Schwieters, C. D.; Choudhari, S.; Fromont, C.; Zhao, Y.; Tran, B.; Chen, X.; Matsuo, H.; Andresson, T.; Chari, R.; Swenson, R. E.; Tarasova, N. I.; Walters, K. J.
10.1101/2021.07.16.452547 — molecular biology — Posted on 2021-07-17
1809 The M2 Gene Is a Determinant of Reovirus-Induced Myocarditis
Dina Zita, M.; Phillips, M. B.; Stuart, J. D.; Kumarapeli, A. R.; Sridharan, V.; Boerma, M.; Snyder, A. J.; Danthi, P.; Boehme, K. W.
10.1101/2021.07.16.452757 — microbiology — Posted on 2021-07-17
1811 Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1
Guo, Y.; Liu, Q.; Mallette, E.; Caba, C.; Hou, F.; Fux, J.; LaPlante, G.; Dong, A.; Zhang, Q.; Zheng, H.; Tong, Y.; Zhang, W.
10.1101/2021.07.16.452720 — biochemistry — Posted on 2021-07-17
1814 The HDL particle composition determines its anti-tumor activity in pancreatic cancer
Bauer, R.; Kuehrer, K. M.; Udonta, F.; Wroblewski, M.; Ben-Batalla, I.; Hassl, I.; Körbelin, J.; Röhrl, C.; Unseld, M.; Jauhiainen, M.; Hengstschläger, M.; Loges, S.; Stangl, H.
10.1101/2021.07.16.452627 — cancer biology — Posted on 2021-07-17
1816 Cooperative DNA base and shape recognition by the CCAAT-binding complex and its bZIP transcription factor HapX
Huber, E. M.; Hortschansky, P.; Scheven, M. T.; Misslinger, M.; Haas, H.; Brakhage, A. A.; Groll, M.
10.1101/2021.07.15.452465 — biochemistry — Posted on 2021-07-17
1817 Allosteric control of Ubp6 and the proteasome via a bidirectional switch
Hung, K. Y. S.; Klumpe, S.; Eisele, M. R.; Elsasser, S.; Tian, G.; Sun, S.; Moroco, J. A.; Cheng, T. C.; Joshi, T.; Seibel, T.; Van Dalen, D.; Feng, X.-H.; Lu, Y.; Ovaa, H.; Engen, J. R.; Lee, B.-H.; Rudack, T.; Sakata, E.; Finley, D.
10.1101/2021.07.16.452743 — biochemistry — Posted on 2021-07-17
1818 Identification of a novel Candida metapsilosis isolate suggests ongoing hybridization.
O'Brien, C. E.; Zhai, B.; Ola, M.; O Cinneide, E.; O'Connor, I.; Rolling, T.; Miranda, E.; Babady, N. E.; Hohl, T. M.; Butler, G.
10.1101/2021.07.15.452539 — genomics — Posted on 2021-07-17
1820 Unravelling the puzzle of anthranoids metabolism in living plant cells using spectral imaging coupled to mass spectrometry
Chevalier, Q.; Galle, J.-B.; Wasser, N.; Mazan, V.; Villette, C.; Mutterer, J.; Elustondo, M. M.; Girard, N.; Elhabiri, M.; Schaller, H.; Hemmerlin, A. M.; Vonthron-Senecheau, C.
10.1101/2021.07.15.452517 — plant biology — Posted on 2021-07-17
1821 Interpersonal synchronization of movement intermittency
Tomassini, A.; Laroche, J.; Emanuele, M.; Nazzaro, G.; Petrone, N.; Fadiga, L.; D'Ausilio, A.
10.1101/2021.06.09.447663 — neuroscience — Posted on 2021-07-17
1823 Accurate Automatic Glioma Segmentation in Brain MRI images Based on CapsNet
Jalili Aziz, M.; Amiri Tehrani Zade, A.; Farnia, P.; Alimohammadi, M.; Makki Abadi, B.; Ahmadian, A.; Alirezaie, J.
10.1101/2021.07.03.450931 — bioengineering — Posted on 2021-07-17
1825 Coupling of pupil- and neuronal population dynamics reveals diverse influences of arousal on cortical processing
Pfeffer, T.; Keitel, C.; Kluger, D. S.; Keitel, A.; Russmann, A.; Thut, G.; Donner, T. H.; Gross, J.
10.1101/2021.06.25.449734 — neuroscience — Posted on 2021-07-17
1828 Mapping the vocal circuitry of Alston's singing mouse with pseudorabies virus
Zheng, D.-J.; Okobi, D. E.; Shu, R.; Agrawal, R.; Smith, S. K.; Long, M. A.; Phelps, S. M.
10.1101/2021.07.16.452718 — neuroscience — Posted on 2021-07-17
1829 The pathogen-encoded signaling receptor Tir exploits host-like intrinsic disorder to assist infection
Vieira, M. F. M.; Hernandez, G.; Veloso, T.; Monteiro, H.; Arbesu, M.; Zanzoni, A.; Cordeiro, T. N.
10.1101/2021.04.22.440577 — biophysics — Posted on 2021-07-17
1830 Define and visualize pathological architectures of human tissues from spatially resolved transcriptomics using deep learning
Chang, Y.; He, F.; Wang, J.; Chen, S.; Li, J.; Liu, J.; Yu, Y.; Su, L.; Ma, A.; Allen, C.; Lin, Y.; Sun, S.; Liu, B.; Otero, J.; Chung, D.; Fu, H.; Li, Z.; Xu, D.; Ma, Q.
10.1101/2021.07.08.451210 — bioinformatics — Posted on 2021-07-16
1833 Development of antibiotic resistance reveals diverse evolutionary pathways to face the complex and dynamic environment of a long-term treated patient
Colque, C. A.; Tomatis, P. E.; Albarracin Orio, A. G.; Dotta, G.; Moreno, D. M.; Hedemann, L. G.; Hickman, R. A.; Sommer, L. M.; Feliziani, S.; Moyano, A. M.; Bonomo, R. A.; Johansen, H. K.; Molin, S.; Vila, A. J.; Smania, A. M.
10.1101/2021.05.14.444257 — microbiology — Posted on 2021-07-16
1838 Posttranslational modification of the RHO of plants protein RACB by phosphorylation and cross-kingdom conserved ubiquitination
Weiss, L.; Reiner, T.; Mergner, J.; Kuster, B.; Feher, A.; Hensel, G.; Gahrtz, M.; Kumlehn, J.; Engelhardt, S.; Huckelhoven, R.
10.1101/2020.05.28.121228 — plant biology — Posted on 2021-07-16
1839 In vivo profiling of site-specific human cancer cell states in zebrafish
Segal, D.; Mazloom-Farsibaf, H.; Chang, B.-J.; Roudot, P.; Rajendran, D.; Warren, M.; Fiolka, R.; Amatruda, J.; Danuser, G.
10.1101/2021.06.09.447621 — cancer biology — Posted on 2021-07-16
1841 AdRoit: an accurate and robust method to infer complex transcriptome composition
Yang, T.; Alessandri-Haber, N.; Fury, W.; Schaner, M.; Breese, R.; LaCroix-Fralish, M.; Kim, J.; Adler, C.; Macdonald, L. E.; Atwal, G. S.; Bai, Y.
10.1101/2020.12.14.422697 — bioinformatics — Posted on 2021-07-16
1842 Non-Newtonian Patient-specific Simulations of Left Atrial Hemodynamics
Gonzalo, A.; Garcia-Villalba, M.; Rossini, L.; Duran, E.; Vigneault, D.; Martinez-Legazpi, P.; Flores, O.; Bermejo, J.; McVeigh, E.; Kahn, A.; del Alamo, J. C.
10.1101/2021.06.24.449801 — bioengineering — Posted on 2021-07-16
1844 The parasite Schistocephalus solidus secretes proteins with putative host manipulation functions
Berger, C. S.; Laroche, J.; Maaroufi, H.; Martin, H.; Moon, K.-M.; Landry, C.; Foster, L.; Aubin-Horth, N.
10.1101/2020.02.03.932509 — genomics — Posted on 2021-07-16
1846 High-resolution single cell transcriptome analysis of zebrafish sensory hair cell regeneration
Baek, S.; Tran, N. T. T.; Diaz, D. C.; Tsai, Y.-Y.; Navajas Acedo, J.; Lush, M. E.; Piotrowski, T.
10.1101/2021.07.15.452338 — developmental biology — Posted on 2021-07-16
1848 Myonuclear maturation dynamics in aged and adult regenerating mouse skeletal muscle
Kurland, J. V.; Deusen, A. V.; Pawlikowski, B.; Hall, M.; Betta, N. D.; Antwine, T.; Cutler, A. A.; Russell, A.; Allen, M. A.; Dowell, R. D.; Olwin, B. B.
10.1101/2021.07.13.452218 — molecular biology — Posted on 2021-07-16
1850 Gut regulatory T cells mediate immunological tolerance in Salmonella Typhimurium-infected superspreader hosts by suppressing cytotoxic activity of T cells.
Moura Massis, L.; Ruddle, S.; Brewer, S. M.; Schade, R.; Narasimhan, R.; Honeycutt, J. D.; Pham, T. H.; McKenna, J. A.; Brubaker, S. W.; Chairatana, P.; Klein, J. A.; Margalef-Catala, M. d. M.; Amieva, M. R.; Vilches-Moure, J. G.; Monack, D. M.
10.1101/2021.07.16.452606 — immunology — Posted on 2021-07-16
1855 ALG-2 interacting protein-X (Alix) is required for activity-dependent bulk endocytosis at brain synapses
Laporte, M. H.; Chi, K. I.; Rolland, M.; Caudal, L. C.; Martinez-Hernandez, J.; Martineau, M.; Chatellard, C.; Denarier, E.; Mercier, V.; Lemaitre, F.; Blot, B.; Moutaux, E.; Cazorla, M.; Perrais, D.; Fraboulet, S.; Lante, F.; Kirchhoff, F.; Hemming, F. J.; Sadoul, R.
10.1101/2020.07.20.211854 — neuroscience — Posted on 2021-07-16
1857 A Population Receptive Field Model of the Magnetoencephalography Response
Kupers, E. R.; Edadan, A.; Benson, N. C.; Zuiderbaan, W.; De Jong, M. C.; Dumoulin, S. O.; Winawer, J.
10.1101/2020.08.28.272534 — neuroscience — Posted on 2021-07-16
1858 Cell fitness is an omniphenotype
Jacobs, N. C.; Park, J.; Saccone, N. L.; Peterson, T. R.
10.1101/487157 — systems biology — Posted on 2021-07-16
1860 Loss of Endothelial HIF-Prolyl hydroxylase 2 (PHD2) Induces Cardiac Hypertrophy and Fibrosis
Dai, Z.; Cheng, J.; Liu, B.; Yi, D.; Feng, A.; Wang, T.; Gao, C.; Wang, Y.; Zhu, M. M.; Zhang, X.; Zhao, Y.
10.1101/2021.03.19.434301 — physiology — Posted on 2021-07-16
1862 An Omic and Multidimensional Spatial Atlas from Serial Biopsies of an Evolving Metastatic Breast Cancer
Johnson, B. E.; Creason, A. L.; Stommel, J. M.; Keck, J. M.; Parmar, S.; Betts, C. B.; Blucher, A.; Boniface, C.; Bucher, E.; Burlingame, E. A.; Camp, T.; Chin, K.; Eng, J.; Estabrook, J.; Feiler, H. S.; Hu, Z.; Kolodzie, A.; Kong, B. L.; Labrie, M.; Lee, J.; Leyshock, P.; Mitri, S.; Patterson, J.; Riesterer, J. L.; Sivagnanam, S.; Somers, J.; Sudar, D.; Thibault, G.; Zheng, C.; Nan, X.; Heiser, L. M.; Spellman, P. T.; Thomas, G. V.; Demir, E.; Chang, Y. H.; Coussens, L. M.; Guimaraes, A. R.; Corless, C.; Goecks, J.; Bergan, R.; Mitri, Z.; Mills, G. B.; Gray, J. W.
10.1101/2020.12.03.408500 — cancer biology — Posted on 2021-07-16
1869 Mechanisms of genetic instability in a single S-phase following whole genome doubling
Gemble, S.; Bernhard, S. V.; Srivastava, N.; Wardenaar, R.; Nano, M.; Mace, A.-S.; Tijhuis, A.; Keuper, K.; Spierings, D. C. J.; Hochegger, H.; Piel, M.; Foijer, F.; Storchova, Z.; Basto, R.
10.1101/2021.07.16.452672 — cell biology — Posted on 2021-07-16
1873 Accurate Direct PCR with Arabidopsis and rice
Lynagh, P.; Hungsaprug, K.; Osuna-Kleist, P.; Malagon, E.; Tan, E. H.; Comai, L.
10.1101/2021.07.16.452406 — molecular biology — Posted on 2021-07-16
1875 Phenotypic determinism and stochasticity in antibody repertoires of clonally expanded plasma cells
Neumeier, D.; Yermanos, A.; Agrafiotis, A.; Csepregi, L.; Chowdhury, T.; Ehling, R. A.; Kuhn, R.; Brisset-Di Roberto, R.; Di Tacchio, M.; Antonialli, R.; Starkie, D.; Lightwood, D. J.; Oxenius, A.; Reddy, S. T.
10.1101/2021.07.16.452687 — immunology — Posted on 2021-07-16
1877 Structural and functional analysis of lorlatinib analogs reveals roadmap for targeting diverse compound resistance mutations in ALK-positive lung cancer
Shiba-Ishii, A.; Johnson, T. W.; Dagogo-Jack, I.; Mino-Kenudson, M.; Johnson, T. R.; Wei, P.; Weinrich, S. L.; McTigue, M. A.; Walcott, M. A.; Nguyen-Phuong, L.; Dionne, K.; Acker, A.; Kiedrowski, L.; Do, A.; Peterson, J. L.; Barth, J. L.; Yeap, B. Y.; Gainor, J. F.; Lin, J. J.; Yoda, S.; Hata, A. N.
10.1101/2021.07.16.452681 — cancer biology — Posted on 2021-07-16
1878 Epigenetic regulator genes direct lineage switching in MLL-AF4 leukaemia
Tirtakusuma, R.; Szoltysek, K.; Milne, P.; Grinev, V. V.; Ptasinska, A.; Meyer, C.; Nakjang, S.; Hehir-Kwa, J. Y.; Williamson, D.; Cauchy, P.; Assi, S. A.; Imperato, M. R.; Vogiatzi, F.; Lin, S.; Wunderlich, M.; Stutterheim, J.; Komkov, A.; Zerkalenkova, E.; Evans, P.; McNeill, H.; Elder, A.; Martinez Soria, N.; Fordham, S. E.; Shi, Y.; Russell, L. J.; Pal, D.; Smith, A.; Kingsbury, Z.; Becq, J.; Eckert, C.; Haas, O. A.; Carey, P.; Bailey, S.; Skinner, R.; Miakova, N.; Collin, M.; Bigley, V.; Haniffa, M.; Marschalek, R.; Harrison, C. J.; Cargo, C. A.; Schewe, D.; Olshanskaya, Y.; Thirman, M. J
10.1101/2021.07.16.452676 — cancer biology — Posted on 2021-07-16
1879 Combining ancestral reconstruction with folding-landscape simulations to engineer heterologous protein expression
Gamiz-Arco, G.; Risso, V. A.; Gaucher, E. A.; Gavira, J. A.; Naganathan, A. N.; Ibarra-Molero, B.; Sanchez-Ruiz, J. M.
10.1101/2021.07.16.452635 — biophysics — Posted on 2021-07-16
1881 Cellular and genetic drivers of RNA editing variation in the human brain
Cuddleston, R.; Li, J.; Fan, X.; Kozenkov, A.; Lalli, M.; Khalique, S.; Dracheva, S.; Mukamel, E. A.; Breen, M. S.
10.1101/2021.07.16.452690 — genetics — Posted on 2021-07-16
1883 Deforestation projections imply range-wide population decline for critically endangered Bornean orangutan
Voigt, M.; Kühl, H. S.; Ancrenaz, M.; Gaveau, D.; Meijaard, E.; Santika, T.; Sherman, J.; Wich, S. A.; Wolf, F.; Struebig, M. j.; Pereira, H. M.; Rosa, I. M.
10.1101/2021.07.16.451448 — ecology — Posted on 2021-07-16
1884 Very Long-Chain Unsaturated Sphingolipids Mediate Oleate-Induced Rat β-Cell Proliferation
Castell, A.-L.; Vivoli, A.; Tippetts, T. S.; Robillard Frayne, I.; Moulle, V. S.; Ruiz, M.; Ghislain, J.; Des Rosiers, C.; Holland, W. L.; Summers, S. A.; Poitout, V.
10.1101/2021.07.16.452686 — cell biology — Posted on 2021-07-16
1885 The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model
Yuste-Checa, P.; Trinkaus, V. A.; Riera-Tur, I.; Imamoglu, R.; Schaller, T.; Wang, H.; Dudanova, I.; Hipp, M. S.; Bracher, A.; Hartl, F. U.
10.1101/2021.07.16.452659 — cell biology — Posted on 2021-07-16
1886 Airborne environmental DNA for terrestrial vertebrate community monitoring
Lynggaard, C.; Bertelsen, M. F.; Jensen, C. V.; Johnson, M. S.; Froslev, T. G.; Olsen, M. T.; Bohmann, K.
10.1101/2021.07.16.452634 — molecular biology — Posted on 2021-07-16
1888 A flexible Bayesian approach to estimating size-structured matrix population models
Mattern, J. P.; Glauninger, K.; Britten, G. L.; Casey, J.; Hyun, S.; Wu, Z.; Armbrust, E. V.; Harchaoui, Z.; Ribalet, F.
10.1101/2021.07.16.452528 — microbiology — Posted on 2021-07-16
1890 Exploring the human cerebral cortex using confocal microscopy
Pesce, L.; Laurino, A.; Scardigli, M.; Yang, J.; Boas, D. A.; Hof, P. R.; Destrieux, C.; Costantini, I.; Pavone, F. S.
10.1101/2021.07.16.452651 — neuroscience — Posted on 2021-07-16
1891 Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss
Wu, T.; Zhu, J.; Strickland, A.; Ko, K. W.; Sasaki, Y.; Dingwall, C.; Yamada, Y.; Figley, M. D.; Mao, X.; Neiner, A.; Bloom, J.; DiAntonio, A.; Milbrandt, J.
10.1101/2021.07.16.452689 — neuroscience — Posted on 2021-07-16
1892 GAIT-GM integrative cross-omics analyses reveal cholinergic defects in a C. elegans model of Parkinson's disease
Mor, D. E.; Huertas, F.; Morse, A. M.; Kaletsky, R.; Murphy, C. T.; Kalia, V.; Miller, G. W.; Moskalenko, O.; Conesa, A.; McIntyre, L. M.
10.1101/2021.07.16.452702 — neuroscience — Posted on 2021-07-16
1896 Tensin3 interaction with talin drives formationof fibronectin-associated fibrillar adhesions
Atherton, P.; Konstantinou, R.; Neo, S. P.; Wang, E.; Balloi, E.; Ptushkina, M.; Bennett, H.; Clark, K.; Gunaratne, J.; Critchley, D.; Barsukov, I.; Manser, E.; Ballestrem, C.
10.1101/2021.07.16.452612 — cell biology — Posted on 2021-07-16
1897 Regeneration of Plants from DNA-free Edited Grapevine Protoplasts
Scintilla, S.; Salvagnin, U.; Giacomelli, L.; Zeilmaker, T.; Malnoy, M. A.; Rouppe van der Voort, J.; Moser, C.
10.1101/2021.07.16.452503 — plant biology — Posted on 2021-07-16
1902 Intestinal organoids expose heterogeneity in SARS-CoV-2 susceptibility
Jang, K. K.; Kaczmarek, M. E.; Dallari, S.; Chen, Y.-H.; Axelrad, J.; Stapleford, K. A.; Cadwell, K.
10.1101/2021.07.16.452680 — cell biology — Posted on 2021-07-16
1905 Non-genetic maternal effects shape individual differences in cortisol phenotypes in wild chimpanzees
Tkaczynski, P. J.; Mafessoni, F.; Girard-Buttoz, C.; Samuni, L.; Ackermann, C. Y.; Fedurek, P.; Gomes, C.; Hobaiter, C.; Lohrich, T.; Manin, V.; Preis, A.; Vale, P.; Wessling, E. G.; Wittiger, L.; Zommers, Z.; Zuberbuehler, K.; Vigilant, L.; Deschner, T.; Wittig, R. M.; Crockford, C.
10.1101/2021.07.16.452609 — zoology — Posted on 2021-07-16
1907 TaBln1 negatively regulates wheat resistance to stripe rust by reducing Ca2+ influx
Guo, S.; Zhang, Y.; Zeng, P.; Li, M.; Zhang, Q.; Li, X.; Xu, Q.; Li, T.; Wang, X.; Kang, Z.; Zhang, X.
10.1101/2021.07.16.452683 — pathology — Posted on 2021-07-16
1910 A new pipeline for the normalization and pooling of metabolomics data
Viallon, V.; His, M.; Rinaldi, S.; Breeur, M.; Gicquiau, A.; Hemon, B.; Overvad, K.; Tjonneland, A.; Rostgaard-Hansen, A. L.; Rothwell, J. A.; Lecuyer, L.; Severi, G.; Kaaks, R.; Johnson, T.; Schulze, M. B.; Palli, D.; Agnoli, C.; Panico, S.; Tumino, R.; Ricceri, F.; Verschuren, M.; Engelfriet, P.; Onland, C.; Vermeulen, R.; Nost, T. H.; Urbarova, I.; Zamora-Ros, R.; Rodriguez-Barranco, M.; Amiano, P.; Huerta, J. M.; Ardanaz, E.; Melander, O.; Ottoson, F.; Vidman, L.; Rentoft, M.; Schmidt, J. A.; Travis, R. C.; Weiderpass, E.; Johansson, M.; Dossus, L.; Jenab, M.; Gunter, M. J.; Bermejo, L.; S
10.1101/2021.07.16.452593 — bioinformatics — Posted on 2021-07-16
1915 A synthetic lethal screen identifies HDAC4 as a potential target in MELK overexpressing cancers
Foijer, F.; Zhou, L.; Rosas Bringas, F. R.; Bakker, B.; Simon, J. E.; Bakker, P. L.; Kazemier, H. G.; Schubert, M.; Roorda, M.; van Vugt, M.; Chang, M.
10.1101/2021.07.16.452653 — genetics — Posted on 2021-07-16
1917 Modeling lung cell development using human pluripotent stem cells
Ngan, Z.; Quach, H.; Dierolf, J.; Lee, J.-A.; Huang, E. N.; Wong, A. P.
10.1101/2021.07.16.452691 — developmental biology — Posted on 2021-07-16
1920 Low dose AKT inhibitor miransertib cures PI3K-related vascular malformations in preclinical models of human disease
Kobialka, P.; Sabata, H.; Vilalta, O.; Angulo-Urarte, A.; Muixi, L.; Zanoncello, J.; Munoz-Aznar, O.; Olaciregui, N. G.; Lavarino, C.; Celis, V.; Rovira, C.; Lopez-Fernandez, S.; Baselga, E.; Mora, J.; Castillo, S. D.; Graupera, M.
10.1101/2021.07.16.452617 — molecular biology — Posted on 2021-07-16
1926 The gut microbiota of environmentally enriched mice regulates visual cortical plasticity
Lupori, L.; Cornuti, S.; Mazziotti, R. M.; Borghi, E.; Ottaviano, E.; Sagona, G.; Pizzorusso, T.; Tognini, P.
10.1101/2021.07.16.452307 — neuroscience — Posted on 2021-07-16
1929 Left-handedness and its genetic influences are associated with structural asymmetries mapped across the cerebral cortex in 31,864 individuals
Sha, Z.; Pepe, A.; Schijven, D.; Carrion Castillo, A.; Roe, J. M.; Westerhausen, R.; Joliot, M.; Fisher, S. E.; Crivello, F.; Francks, C.
10.1101/2021.07.16.452594 — neuroscience — Posted on 2021-07-16
1940 Quantifying and correcting slide-to-slide variation in multiplexed immunofluorescence images
Harris, C. R.; McKinley, E. T.; Roland, J. T.; Liu, Q.; Shrubsole, M. J.; Lau, K.; Coffey, R. J.; Wrobel, J.; Vandekar, S.
10.1101/2021.07.16.452359 — bioinformatics — Posted on 2021-07-16
1944 Active inference through whiskers
Mannella, F.; Maggiore, F.; Baltieri, M.; Pezzulo, G.
10.1101/2021.07.16.452665 — animal behavior and cognition — Posted on 2021-07-16
1945 Network-based pathogenicity prediction for variants of uncertain significance
Kamada, M.; Takagi, A.; Kojima, R.; Tanaka, Y.; Nakatsui, M.; Tanabe, N.; Hirata, M.; Yoshida, T.; Okuno, Y.
10.1101/2021.07.15.452566 — genomics — Posted on 2021-07-16
1947 Innate immune pathways act synergistically to constrain RNA virus evolution in Drosophila melanogaster
Mongelli, V.; Lequime, S.; Kousathanas, A.; Gausson, V.; Blanc, H.; Quintana-Murci, L.; Elena, S. F.; Saleh, M.-C.
10.1101/2021.07.16.452470 — evolutionary biology — Posted on 2021-07-16
1949 TGF-β modulates cell fate in human ES cell-derived foregut endoderm by inhibiting multiple endogenous signaling pathways
Funa, N. S.; de Lichtenberg, K. H.; Hansen, M. S.; Kuylenstierna, J. v. C.; Jensen, K. B.; Miao, Y.; Garcia, K. C.; Serup, P.
10.1101/2021.07.15.452587 — developmental biology — Posted on 2021-07-16
1950 The molecular architecture of vimentin filaments
Eibauer, M.; Weber, M. S.; Turgay, Y.; Sivagurunathan, S.; Goldman, R. D.; Medalia, O.
10.1101/2021.07.15.452584 — cell biology — Posted on 2021-07-16
1951 The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin
Krastev, D. B.; Li, S.; Sun, Y.; Wicks, A.; Weekes, D.; Badder, L. M.; Knight, E. G.; Marlow, R.; Pardo Calvo, M.; Yu, L.; Talele, T. T.; Bartek, J.; Choudhary, J.; Pommier, Y.; Pettitt, S. J.; Tutt, A.; Ramadan, K.; Lord, C. J.
10.1101/2021.07.16.452473 — molecular biology — Posted on 2021-07-16
1952 An oligosaccharide analog exhibited antifungal activity by misleading cell wall organization via targeting PHR transglucosidases
Li, R.; Wang, Z.; Zhu, L.; Liu, D.; Wang, W.; Zhang, C.; Jiao, S.; Wei, J.; Ren, L.; Zhang, Y.; Gou, X.; Yuan, X.; Du, Y.
10.1101/2021.07.16.452596 — microbiology — Posted on 2021-07-16
1954 Collaboration Between Host and Viral Factors Shape SARS-CoV-2 Evolution
Bamford, C. G. G.; Broadbent, L.; Aranday Cortes, E.; McCabe, M.; McKenna, J.; Courtney, D.; Touzelet, O.; Ali, A.; Roberts, G.; Lopez Campos, G.; Simpson, D.; McCaughey, C.; Fairley, D.; Mills, K.; Power, U. F.; The Breathing Together Consortium,
10.1101/2021.07.16.452629 — microbiology — Posted on 2021-07-16
1955 BET protein inhibition regulates macrophage chromatin accessibility and microbiota-dependent colitis
Hoffner O'Connor, M.; Berglind, A.; Kennedy, M. M.; Keith, B. P.; Lynch, Z. J.; Schaner, M. R.; Steinbach, E. C.; Herzog, J.; Trad, O. K.; Jeck, W. R.; Arthur, J. C.; Sartor, R. B.; Furey, T.; Sheikh, S. Z.
10.1101/2021.07.15.452570 — immunology — Posted on 2021-07-16
1957 Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection
Sasaki, Y.; Zhu, J.; Shi, Y.; Gu, W.; Kobe, B.; Ve, T.; DiAntonio, A.; Milbrandt, J.
10.1101/2021.07.15.452560 — neuroscience — Posted on 2021-07-16
1958 BAI-Net: Individualized Human Cerebral Cartography using Graph Convolutional Network
Ma, L.; Zhang, Y.; Zhang, H.; Cheng, L.; Zhuo, J.; Shi, W.; Lu, Y.; Li, W.; Wang, J.; Yang, Z.; Fan, L.; Jiang, T.
10.1101/2021.07.15.452577 — neuroscience — Posted on 2021-07-16
1959 Structural connectivity-based segmentation of the human entorhinal cortex
Syversen, I. F.; Witter, M. P.; Kobro-Flatmoen, A.; Goa, P. E.; Navarro Schröder, T.; Doeller, C. F.
10.1101/2021.07.16.452500 — neuroscience — Posted on 2021-07-16
1961 Antipsychotic-induced epigenomic reorganization in frontal cortex samples from individuals with schizophrenia
Zhu, B.; Ainsworth, R. I.; Wang, Z.; Sierra, S.; Deng, C.; Callado, L. F.; Meana, J. J.; Wang, W.; Lu, C.; Gonzalez-Maeso, J.
10.1101/2021.07.14.452426 — neuroscience — Posted on 2021-07-16
1963 Climatic niche pre-adaptation in mainland Europe facilitated the colonization of Madeira by ivies (Hedera L., Araliaceae)
Alonso, A.; Gallego-Narbon, A.; Coca-de-la-Iglesia, M.; Monjas, D.; G. Medina, N.; Fernandez-Mazuecos, M.; Valcarcel, V.
10.1101/2021.07.16.452604 — plant biology — Posted on 2021-07-16
1966 On the Apportionment of Archaic Human Diversity
Villanea, F. A.; Witt, K. E.; Loughran, E.; Huerta-Sanchez, E. A.
10.1101/2021.07.15.452563 — genomics — Posted on 2021-07-16
1967 Engineering functional human gastrointestinal organoid tissues using the three primary germ layers separately derived from pluripotent stem cells
Eicher, A. K.; Kechele, D. O.; Sundaram, N.; Berns, H. M.; Poling, H. M.; Haines, L. E.; Sanchez, J. G.; Kishimoto, K.; Krishnamurthy, M.; Han, L.; Zorn, A. M.; Helmrath, M. A.; Wells, J. M.
10.1101/2021.07.15.452523 — developmental biology — Posted on 2021-07-16
1968 Latent neural dynamics encode temporal context in speech
Stephen, E. P.; Li, Y.; Metzger, S.; Oganian, Y.; Chang, E. F.
10.1101/2021.07.15.452519 — neuroscience — Posted on 2021-07-16
1970 Experience-Driven Rate Modulation is Reinstated During Hippocampal Replay
Tirole, M.; Huelin Gorriz, M.; Takigawa, M.; Kukovska, L.; Bendor, D.
10.1101/2021.07.15.452506 — neuroscience — Posted on 2021-07-16
1972 Hyperbolic trade-off: the importance of balancing trial and subject sample sizes in neuroimaging
Chen, G.; Pine, D. S.; Brotman, M. A.; Smith, A. R.; Cox, R. W.; Taylor, P. A.; Haller, S. P.
10.1101/2021.07.15.452548 — neuroscience — Posted on 2021-07-16
1973 GuPPy, a Python toolbox for the analysis of fiber photometry data
Sherathiya, V. N.; Schaid, M. D.; Seiler, J. L.; Lopez, G. C.; Lerner, T.
10.1101/2021.07.15.452555 — neuroscience — Posted on 2021-07-16
1979 A genome-wide CRISPR/Cas9 knock-out screen identifies the DEAD box RNA helicase DDX42 as a broad antiviral inhibitor
Bonaventure, B.; Rebendenne, A.; Garcia de Gracia, F.; McKellar, J.; Gracias, S.; Labaronne, E.; Tauziet, M.; Chaves Valadao, A. L.; Bernard, E.; Briant, L.; Gros, N.; Djilli, W.; Arnaud-Arnould, M.; Courgnaud, V.; Parrinello, H.; Rialle, S.; Schulz, R.; Ricci, E. P.; Jouvenet, N.; Moncorge, O.; Goujon, C.
10.1101/2020.10.28.359356 — microbiology — Posted on 2021-07-16
1981 SARS-CoV-2 B.1.617.2 Delta variant emergence, replication and immune evasion
Mlcochova, P.; Kemp, S. A.; Shanker Dhar, M.; Papa, G.; Meng, B.; Mishra, S.; Whittaker, C.; Mellan, T.; Ferreira, I.; Datir, R.; Collier, D.; Singh, S.; Pandey, R.; Ponnusamy, K.; Radhakrishnan, V. S.; Sengupta, S.; Brown, J.; Marwal, R.; Ponnusamy, K.; Radhakrishnan, V. S.; Goonawardne, N.; Abdullahi, A.; Devi, P.; Wattal, C.; Caputo, D.; Peacock, T.; Goel, N.; Vaishya, R.; Charles, O.; Chattopadhyay, P.; Agarwal, M.; Satwik, A.; INSACOG CONSORTIUM, ; NIHR Bioresource Collaboration, ; Mavousian, A.; Brown, J.; Zhou, J.; Goonawardne, N.; Hyeon Lee, J.; Bassi, J.; Silacci-Fegni, C.; Saliba,
10.1101/2021.05.08.443253 — microbiology — Posted on 2021-07-16
1983 Theta activity paradoxically boosts gamma and ripple frequency sensitivity in prefrontal interneurons
Merino, R. M.; Leon-Pinzon, C.; Stuehmer, W.; Moeck, M.; Staiger, J. F.; Wolf, F.; Neef, A.
10.1101/2019.12.19.882639 — neuroscience — Posted on 2021-07-16
1988 Plasmin-mediated cleavage of EphA4 at central amygdala inhibitory synapses controls anxiety
Mucha, M.; Labrador-Ramos, A.; Attwood, B.; Bajor, M.; Kolenchery, J.; Skrzypiec, A.; Brambilla, V.; Magnowska, M.; Figiel, I.; Swiatek, M.; Wiktorowska, L.; Shah, R. S.; Pijet, B.; Sakai, Y.; Nagai, N.; Klejman, A.; Wlodarczyk, J.; Kaczmarek, L.; Przewlocki, R.; Pawlak, R.
10.1101/2021.07.16.452595 — neuroscience — Posted on 2021-07-16
1991 SMC complexes can traverse physical roadblocks bigger than their ring size
Pradhan, B.; Barth, R.; Kim, E.; Davidson, I. F.; Bauer, B.; van Laar, T.; Yang, W.; Ryu, J.-K.; van der Torre, J.; Peters, J.-M.; Dekker, C.
10.1101/2021.07.15.452501 — biophysics — Posted on 2021-07-16
1993 Allele-resolved single-cell multi-omics uncovers the dynamics and transcriptional kinetics of X-chromosome upregulation
Lentini, A.; Cheng, H.; Noble, J.; Papanicolaou, N.; Coucoravas, C.; Andrews, N.; Deng, Q.; Enge, M.; Reinius, B.
10.1101/2021.07.14.452323 — genomics — Posted on 2021-07-15
1994 The myopathic transcription factor DUX4 induces the production of truncated RNA-bindingproteins in human muscle cells
Campbell, A. E.; Dyle, M. C.; Calviello, L.; Matheny, T.; Cortazar, M. A.; Forman, T.; Fu, R.; Gillen, A. E.; Floor, S. N.; Jagannathan, S.
10.1101/2021.06.28.450189 — genomics — Posted on 2021-07-16
1995 Active enhancers strengthen TAD insulation by bRNA mediated CTCF enrichment at the TAD boundaries
Islam, Z.; Saravanan, B.; Walavalkar, K.; Farooq, U.; Singh, A. K.; Thakur, J.; Pandit, A.; Sabarinathan, R.; Henikoff, S.; Notani, D.
10.1101/2021.07.13.452118 — genomics — Posted on 2021-07-16
1998 Actin force generation in vesicle formation: mechanistic insights from cryo-electron tomography
Serwas, D.; Akamatsu, M.; Moayed, A.; Vegesna, K.; Vasan, R.; Hill, J. M.; Schoeneberg, J.; Davies, K. M.; Rangamani, P.; Drubin, D. G.
10.1101/2021.06.28.450262 — cell biology — Posted on 2021-07-15
1999 Differential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment
Guma, E.; Bordeleau, M.; Snook, E.; Desrosiers-Gregoire, G.; Gonzalez Ibanez, F.; Picard, K.; Spring, S.; Lerch, J. P.; Nieman, B. J.; Devenyi, G. A.; Tremblay, M.-E.; Chakravarty, M. M.
10.1101/2021.07.14.452084 — neuroscience — Posted on 2021-07-15
2001 BitEpi: A Fast and Accurate Exhaustive Higher-Order Epistasis Search
Bayat, A.; Hosking, B.; Jain, Y.; Hosking, C.; Kodikara, M.; Reti, D.; Twine, N.; C. Bauer, D.
10.1101/858282 — bioinformatics — Posted on 2021-07-15
2003 Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits - the Hispanic/Latino Anthropometry Consortium
Fernandez-Rhodes, L.; Graff, M.; Buchanan, V. L.; Justice, A. E.; Highland, H. M.; Guo, X.; Young, K. L.; Adhikari, K.; Allred, N. P.; Below, J. E.; Bradfield, J.; Pereira, A. C.; Glover, L.; Kim, D.; Lilly, A. G.; Shrestha, P.; Thomas, A. G.; Zhang, X.; Chen, M.; Chiang, C.; Pulit, S.; Horimoto, A.; Krieger, J. E.; Guindo-Martinez, M.; Preuss, M.; Schumann, C.; Smit, R. A. J.; Torres-Mejia, G.; Acuna-Alonzo, V.; Bedoya, G.; Bortolini, M.-C.; Canizales-Quinteros, S.; Gallo, C.; Gonzalez-Jose, R.; Poletti, G.; Rothhammer, F.; Hakonarson, H.; Adler, S. G.; Igo, R.; Iyengar, S.; Nicholas, S. B.;
10.1101/2021.05.27.445969 — genetics — Posted on 2021-07-15
2004 Non-invasive imaging of gene expression and protein secretion dynamics in living mice
Nourse, J.; Tokalov, S.; Khokhar, S.; Khan, E.; Schott, L. K.; Hinz, L.; Eder, L.; Arnold-Schild, D.; Probst, H. C.; Danckwardt, S.
10.1101/2021.07.08.451623 — genetics — Posted on 2021-07-15
2006 The haplotype-based analysis of Aegilops tauschii introgression into hard red winter wheat and its impact on productivity traits
Nyine, M.; Adhikari, E.; Clinesmith, M.; Aiken, R.; Betzen, B.; wang, w.; Davidson, D.; Yu, Z.; Guo, Y.; He, F.; Akhunov, A.; Jordan, K. W.; Fritz, A. K.; Akhunov, E.
10.1101/2021.05.29.446303 — genetics — Posted on 2021-07-15
2008 Heterogeneity in the transcriptional response of the human pathogen Aspergillus fumigatus to the antifungal agent caspofungin
Colabardini, A. C.; Wang, F.; Dong, Z.; Pardeshi, L.; Rocha, M. C.; Costa, J. H.; dos Reis, T. F.; Brown, A.; Jaber, Q. Z.; Fridman, M.; Fill, T.; Rokas, A.; Malavazi, I.; Wong, K. H.; Goldman, G. H.
10.1101/2021.07.15.452449 — microbiology — Posted on 2021-07-15
2009 Inactivation effects of plasma-activated water on Fusarium graminearum
Guo, J.; Wang, J.; Xie, H.; Jiang, J.; Li, C.; Li, W.; Li, L.; Liu, X.; Lin, F.
10.1101/2021.07.15.452455 — microbiology — Posted on 2021-07-15
2012 Exosome TDP-43 profile in canine model of ALS: A preliminary study in developing surrogate biomarker
Pfeiffer, P.; Coates, J. R.; Esqueda, Y. M.; Kennedy, A.; Getchell, K.; McLenon, M.; Kosa, E.; Agbas, A.
10.1101/2021.06.17.448876 — neuroscience — Posted on 2021-07-15
2017 Minimizing the ex vivo confounds of cell-isolation techniques on transcriptomic profiles of purified microglia
Ocanas, S. R.; Pham, K. D.; Blankenship, H. E.; Machalinski, A. H.; Chucair-Elliott, A. J.; Freeman, W. M.
10.1101/2021.07.15.452509 — neuroscience — Posted on 2021-07-15
2020 Long distance runners in the marine realm: New insights into genetic diversity, kin relationships and social fidelity of Indian Ocean male sperm whales
Girardet, J.; Sarano, F.; Richard, G.; Tixier, P.; Guinet, C.; Alexander, A.; Sarano, V.; Vitry, H.; Preud'Homme, A.; Heuzey, R.; Garcia-Cegarra, A. M.; Adam, O.; Madon, B.; Jung, J.-L.
10.1101/2021.04.23.440733 — ecology — Posted on 2021-07-15
2022 CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels
Gonçalves, A. B.; Hasselbalch, S. K.; Joensen, B. B.; Patzke, S.; Martens, P.; Ohlsen, S. K.; Quinodoz, M.; Nikopoulus, K.; Suleiman, R.; Jeppesen, M. P. D.; Weiss, C.; Christensen, S. T.; Rivolta, C.; Andersen, J. S.; Farinelli, P.; Pedersen, L. B.
10.1101/2020.10.05.325936 — cell biology — Posted on 2021-07-15
2023 LincRNA-Cox2 functions to regulate inflammation in alveolar macrophages during acute lung injury.
Robinson, E. K.; Worthington, A. K.; Poscablo, D. M.; Shapleigh, B.; Salih, M. M.; Halasz, H.; Seninge, L.; Mosqueira, B.; Smaliy, V.; Forsberg, E. C.; Carpenter, S.
10.1101/2021.07.15.452529 — immunology — Posted on 2021-07-15
2025 Chr21 protein-protein interactions: enrichment in products involved in intellectual disabilities, autism and Late Onset Alzheimer Disease
Viard, J.; Loe-Mie, Y.; Khelfaoui, M.; Daudin, R.; Plancon, C.; Boland, A.; Tejedor, F.; Huganir, R.; Kim, E.; Kinoshita, M.; Liu, G.; Haucke, V.; Moncion, T.; Yu, E.; Hindie, V.; Blehaut, H.; Mircher, C.; Herault, Y.; Deleuze, J.-F.; Rain, J.-C.; Simonneau, M.; Lepagnol-Bestel, A.-M.
10.1101/2019.12.11.872606 — neuroscience — Posted on 2021-07-15
2026 On stability of Canonical Correlation Analysis and Partial Least Squares with application to brain-behavior associations
Helmer, M.; Warrington, S. D.; Mohammadi-Nejad, A.-R.; Ji, J. L.; Howell, A.; Rosand, B.; Anticevic, A.; Sotiropoulos, S. N.; Murray, J. D.
10.1101/2020.08.25.265546 — neuroscience — Posted on 2021-07-15
2028 GPR39 Localization in Aging Human Brain and Correlation of Expression and Polymorphism with Vascular Cognitive Impairment
Davis, C.; Bah, T.; Zhang, W.; Nelson, J.; Golgotiu, K.; Nie, X.; Alkayed, F.; Young, J.; Woltjer, R.; Silbert, L.; Grafe, M.; Alkayed, N. J.
10.1101/2021.07.15.452525 — neuroscience — Posted on 2021-07-15
2029 Synaptic decline precedes dopaminergic neuronal loss in human midbrain organoids harboring a triplication of the SNCA gene
Modamio, J.; Saraiva, C.; Gomez-Giro, G.; Nickels, S. L.; Jarazo, J.; Antony, P.; Barbuti, P.; Halder, R.; Jaeger, C.; Krueger, R.; Glaab, E.; Schwamborn, J. C.
10.1101/2021.07.15.452499 — neuroscience — Posted on 2021-07-15
2031 A Scalable, Open-Source Implementation of a Large-Scale Mechanistic Model for Single Cell Proliferation and Death Signaling
Erdem, C.; Mutsuddy, A.; Bensman, E. M.; Dodd, W.; Saint-Antoine, M. M.; Bouhaddou, M.; Blake, R. C.; Gross, S. M.; Heiser, L. M.; Feltus, F. A.; Birtwistle, M. R.
10.1101/2020.11.09.373407 — systems biology — Posted on 2021-07-15
2033 Decellularized Normal and Tumor Scaffolds for Cancer Organoid Cultures as a Model of Colorectal Peritoneal Metastases
Varinelli, L.; Guaglio, M.; Brich, S.; Zanutto, S.; Belfiore, A.; Zanardi, F.; Iannelli, F.; Oldani, A.; Costa, E.; Chighizola, M.; Minardi, S. P.; Fortuzzi, S.; Filugelli, M.; Garzone, G.; Vecchi, M.; Pruneri, G.; Kusamura, S.; Baratti, D.; Cattaneo, L.; Parazzoli, D.; Podesta, A.; Milione, M.; Deraco, M.; Pierotti, M. A.; Gariboldi, M.
10.1101/2021.07.15.452437 — cancer biology — Posted on 2021-07-15
2034 CHRM1 is a Druggable Melanoma Target Whose Endogenous Activity is Determined by Inherited Genetic Variation in DOPA Production
Doepner, M.; Natale, C. A.; Lee, I. Y.; Venkat, S.; Kim, S. H.; Katzenellenbogen, J. A.; Katzenellenbogen, B. S.; Feigin, M.; Ridky, T. W.
10.1101/2021.03.03.433757 — cancer biology — Posted on 2021-07-15
2036 Deep Learning Achieves Neuroradiologist-Level Performance in Detecting Hydrocephalus
Huang, Y.; Moreno, R.; Malani, R.; Meng, A.; Swinburne, N.; Holodny, A. I.; Choi, Y.; Parra, L. C.; Young, R. J.
10.1101/2021.01.19.427328 — bioinformatics — Posted on 2021-07-15
2037 Bioinformatic and mechanistic analysis of the palmerolide PKS-NRPS biosynthetic pathway from the microbiome of an Antarctic ascidian
Avalon, N. E.; Murray, A. E.; Daligault, H. E.; Lo, C.-C.; Dichosa, A. E. K.; Davenport, K. W.; Chain, P. S. G.; Baker, B. J.
10.1101/2021.04.05.438531 — biochemistry — Posted on 2021-07-15
2041 Cell-free DNA Profiling Informs Major Complications of Hematopoietic Cell Transplantation
Cheng, A. P.; Cheng, M. P.; Loy, C. J.; Lenz, J. S.; Chen, K.; Smalling, S.; Burnham, P.; Timblin, K. M.; Orejas, J. L.; Silverman, E.; Polak, P.; Marty, F. M.; Ritz, J.; De Vlaminck, I.
10.1101/2020.04.25.061580 — genomics — Posted on 2021-07-15
2045 The Mitochondrial Permeability Transition Pore Activates the Mitochondrial Unfolded Protein Response and Promotes Aging
Angeli, S.; Foulger, A.; Chamoli, M.; Peiris, T. H.; Gerencser, A.; Shahmirzadi, A. A.; Andersen, J.; Lithgow, G.
10.1101/2020.11.03.366815 — cell biology — Posted on 2021-07-15
2046 Monitoring the spread of SARS-CoV-2 variants in Moscow and the Moscow region using targeted high-throughput sequencing
Borisova, N. I.; Kotov, I. A.; Kolesnikov, A. A.; Kaptelova, V. V.; Speranskaya, A. S.; Kondrasheva, L. Y.; Tivanova, E. V.; Khafizov, K.; Akimkin, V. G.
10.1101/2021.07.15.452488 — molecular biology — Posted on 2021-07-15
2049 Antagonists targeting eEF2 kinase rescue multiple aspects of pathophysiology in Alzheimer's disease model mice
Kasica, N. P.; Zhou, X.; Wang, X.; Yang, W. P.; Zimmermann, H. R.; Holland, C. E.; Koscielniak, E.; Wu, H.; Cox, A. O.; Lee, J.; Ryazanov, A. G.; Furdui, C. M.; Ma, T.
10.1101/2021.07.15.452522 — neuroscience — Posted on 2021-07-15
2051 Revealing Protein-Level Functional Redundancy in the Human Gut Microbiome using Ultra-deep Metaproteomics
Li, L.; Ning, Z.; Zhang, X.; Butcher, J.; Simopoulos, C.; Mayne, J. M. A.; Stintzi, A.; Mack, D. R.; Liu, Y.-Y.; Figeys, D.
10.1101/2021.07.15.452564 — systems biology — Posted on 2021-07-15
2053 Cellular aging in vitro recapitulates multi-tissue epigenetic aging in vivo
Minteer, C.; Morselli, M.; Meer, M.; Cao, J.; Higgins-Chen, A.; Lang, S.; Pellegrini, M.; Yan, Q.; Levine, M.
10.1101/2020.09.02.280073 — pathology — Posted on 2021-07-15
2054 SARS-Cov-2 Spike binding to ACE2 is stronger and longer ranged with glycans
Huang, Y.; Harris, B. S.; Minami, S. A.; Jung, S.; Shah, P.; Nandi, S.; McDonald, K.; Faller, R.
10.1101/2021.07.15.452507 — biophysics — Posted on 2021-07-15
2056 Gut microbiome dysbiosis during COVID-19 is associated with increased risk for bacteremia and microbial translocation.
Venzon, M.; Bernard-Raichon, L.; Klein, J.; Axelrad, J. E.; Hussey, G. A.; Sullivan, A. P.; Cassanovas-Massana, A.; Noval, M. G.; Valero-Jimenez, A. M.; Gago, J.; Wilder, E.; Yale IMPACT Research Team, ; Thorpe, L. E.; Littman, D. R.; Dittmann, M.; Stapleford, K. A.; Shopsin, B.; Torres, V. J.; Ko, A. I.; Iwasaki, A.; Cadwell, K.; Schluter, J.
10.1101/2021.07.15.452246 — microbiology — Posted on 2021-07-15
2057 Supervised generative design of regulatory DNA forgene expression control
Zrimec, J.; Fu, X.; Muhammad, A. S.; Skrekas, C.; Jauniskis, V.; Speicher, N.; Boerlin, C. S.; Verendel, V.; Dubhashi, D.; Chehreghani, M. H.; Siewers, V.; David, F.; Nielsen, J.; Zelezniak, A.
10.1101/2021.07.15.452480 — synthetic biology — Posted on 2021-07-15
2059 Crosstalk between Flavonoids and the Plant Circadian Clock
Hildreth, S. B.; Littleton, E. S.; Clark, L. C.; Puller, G. C.; Kojima, S.; Winkel, B. S. J.
10.1101/2021.07.15.452546 — plant biology — Posted on 2021-07-15
2060 Gut microbiota-based vaccination engages innate immunity to improve blood glucose control in obese mice
Duggan, B. M.; Tamrakar, A. K.; Barra, N. G.; Anhe, F. F.; Paniccia, G.; Wallace, J. G.; Stacey, H. D.; Miller, M. S.; Sloboda, D. M.; Schertzer, J. D.
10.1101/2021.07.15.452537 — physiology — Posted on 2021-07-15
2063 Effects of a 33-sequential beam galactic cosmic ray analog on male mouse behavior and evaluation of CDDO-EA as a radiation countermeasure
Kiffer, F. C.; Luitel, K.; Tran, F. H.; Patel, R. A.; Guzman, C. S.; Soler, I.; Xiao, R.; Shay, J. W.; Yun, S.; Eisch, A. J.
10.1101/2021.07.15.451917 — animal behavior and cognition — Posted on 2021-07-15
2064 Functional and Structural Segregation of Overlapping Helices in HIV-1
Safari, M.; Jayaraman, B.; Yang, S.; Smith, C.; Fernandes, J. D.; Frankel, A. D.
10.1101/2021.07.15.452440 — evolutionary biology — Posted on 2021-07-15
2066 Measuring biodiversity from DNA in the air
Clare, E. L.; Economou, C. K.; Bennett, F. J.; Dyer, C. E.; Adams, K.; McRobie, B.; Drinkwater, R.; Littlefair, J. E.
10.1101/2021.07.15.452392 — ecology — Posted on 2021-07-15
2068 Single cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccine
Sureshchandra, S.; Lewis, S. A.; Doratt, B.; Jankeel, A.; Ibraim, I.; Messaoudi, I.
10.1101/2021.07.14.452381 — immunology — Posted on 2021-07-15
2071 Chromatin alterations in the aging lung change progenitor cell activity
Rowbotham, S. P.; Pessina, P.; Garcia de Alba Rivas, C.; Li, J.; Wong, I.; Yoon, J.; Fahey, C.; Moye, A.; Chongsaritsinsuk, J.; Bronson, R.; Ho Sui, S. J.; Kim, C. F.
10.1101/2021.07.15.452072 — molecular biology — Posted on 2021-07-15
2072 Novel municipal sewage-associated bacterial genomes and their potential in source tracking
Lindner, B. G.; Suttner, B.; Conrad, R. E.; Rodriguez-R, L. M.; Hatt, J. K.; Zhu, K. J.; Brown, J.; Konstantinidis, K. T.
10.1101/2021.07.15.452399 — microbiology — Posted on 2021-07-15
2074 Mining bacterial NGS data vastly expands the complete genomes of temperate phages
Zhang, X.; Wang, R.; Xie, X.; Hu, Y.; Wang, J.; Sun, Q.; Feng, X.; Tong, S.; Cui, Y.; Wang, M.; Zhai, S.; Niu, Q.; Wang, F.; Kropinski, A. M.; Jiang, X.; Peng, S.; Li, S.; Tong, Y.
10.1101/2021.07.15.452192 — bioinformatics — Posted on 2021-07-15
2078 Phenotypic and genomic diversification in complex carbohydrate degrading human gut bacteria
Pudlo, N. A.; Urs, K.; Crawford, R.; Pirani, A.; Atherly, T.; Jimenez, R.; Terrapon, N.; Henrissat, B.; Peterson, D. A.; Ziemer, C.; Snitkin, E. S.; Martens, E.
10.1101/2021.07.15.452266 — microbiology — Posted on 2021-07-15
2079 IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay
Akaki, K.; Ogata, K.; Yamauchi, Y.; Iwai, N.; Tse, K. M.; Hia, F.; Mochizuki, A.; Ishihama, Y.; Mino, T.; Takeuchi, O.
10.1101/2021.07.15.452458 — immunology — Posted on 2021-07-15
2080 Fatty Alcohols, a Minor Component of the Tree Tobacco Surface Wax, Reduce Insect Herbivory
Negin, B.; Shachar, L.; Meir, S.; Ramirez, C. C.; Horowitz, A. R.; Jander, G.; Aharoni, A.
10.1101/2021.07.15.452450 — plant biology — Posted on 2021-07-15
2081 INFIMA leverages multi-omics model organism data to identify effector genes of human GWAS variants
Dong, C.; Simonett, S. P.; Shin, S.; Stapleton, D. S.; Schueler, K. L.; Churchill, G. A.; Lu, L.; Liu, X.; Jin, F.; Li, Y.; Attie, A. D.; Keller, M. P.; Keles, S.
10.1101/2021.07.15.452422 — bioinformatics — Posted on 2021-07-15
2082 Potato juice, a starch industry waste, as a cost-effective medium for the biosynthesis of bacterial cellulose
Ciecholewska-Jusko, D.; Broda, M.; Zywicka, A.; Styburski, D.; Sobolewski, P.; Goracy, K.; Migdal, P.; Junka, A.; Fijalkowski, K.
10.1101/2021.07.15.452442 — bioengineering — Posted on 2021-07-15
2085 Evolution of DNA methylation across Ecdysozoa
Engelhardt, J.; Scheer, O.; Stadler, P. F.; Prohaska, S. J.
10.1101/2021.07.15.452454 — evolutionary biology — Posted on 2021-07-15
2087 RAD51AP1 compensates for the loss of RAD54 in homology-directed DNA repair
Selemenakis, P.; Sharma, N.; Kwon, Y.; Uhrig, M.; Sung, P.; Wiese, C.
10.1101/2021.07.15.452469 — cell biology — Posted on 2021-07-15
2091 Age-Related Changes in the Rhesus Macaque Eye
Lin, K.; Tran, T.; Kim, S.; Park, S.; Chen, J.; Stout, J. T.; Chen, R.; Rogers, J.; Yiu, G.; Thomasy, S.; Moshiri, A.
10.1101/2021.07.14.452427 — systems biology — Posted on 2021-07-15
2101 Differential requirements for mitochondrial electron transport chain components in the adult murine liver
Lesner, N. P.; Wang, X.; Frank, A.; House, S.; Shelton, S. D.; McFadden, D. G.; DeBerardinis, R. J.; Mishra, P.
10.1101/2021.07.15.452466 — cell biology — Posted on 2021-07-15
2102 Reciprocal regulation of Shh trafficking and H2O2 levels via a noncanonical BOC-Rac1 pathway
Thauvin, M.; Amblard, I.; Rampon, C.; Mourton, A.; Queguiner, I.; Li, C.; Gautier, A.; Joliot, A.; Volovitch, M.; VRIZ, S.
10.1101/2021.07.15.452471 — cell biology — Posted on 2021-07-15
2104 The Antimicrobial Efficacy Of Plasma Activated Water Is Modulated By Reactor Design And Water Composition
Rothwell, J. G.; Alam, D.; Carter, D. A.; Soltani, B.; McConchie, R.; Zhou, R.; Cullen, P. J.; Mai-Prochnow, A.
10.1101/2021.07.14.452435 — microbiology — Posted on 2021-07-15
2107 Long-Term Protective Effects of Single-Dose infusion of Warm Blood Cardioplegic Solution in a mini-pig model on the background of intraoperative anemia
Yavorovskiy, A. G.; Komarov, R. N.; Kogan, E. A.; Mandel, I. A.; Panov, A. V.; Bagdasarov, P. S.; Bulanova, E. L.; Khalikova, E. Y.; Popov, A. M.
10.1101/2021.07.15.452431 — physiology — Posted on 2021-07-15
2108 Cellular Pharmacology of Curcumin With and Without Piperine
Mahran, R. I.; Shu, P.; Colacino, J.; Hagras, M. M.; Sun, D.; Brenner, D. E.
10.1101/2021.07.14.452424 — pharmacology and toxicology — Posted on 2021-07-15
2115 Increased intestinal permeability in an orally-reactive peanut allergy model identifies Angiopoietin like-4 as a biomarker
Steinbach, E. C.; Smeekens, J. M.; Roy, S.; Toyonaga, T.; Cornaby, C.; Perini, L. B.; Berglind, A. E.; Kulis, M. D.; Kim, E. H.; Ferris, M. T.; Furey, T. S.; Burks, A. W.; Sheikh, S. Z.
10.1101/2021.07.14.452416 — cell biology — Posted on 2021-07-15
2116 Ing4-deficiency enhances HSC quiescence and confers resistance to inflammatory stress
Thompson, Z.; Anderson, G. A.; Rodriguez, M.; Gabriel, S.; Binder, V.; Taylor, A. M.; Kathrein, K. L.
10.1101/2021.07.14.452366 — cell biology — Posted on 2021-07-15
2121 Alterations in leptin signaling in Amyotrophic Lateral Sclerosis (ALS)
Ferrer-Donato, A.; Contreras, A.; Frago, L. M.; Chowen, J. A.; Fernandez-Martos, C. M.
10.1101/2021.07.14.452319 — neuroscience — Posted on 2021-07-15
2123 Modeling Allelic Diversity of Multi-parent Mapping Populations Affects Detection of Quantitative Trait Loci
Odell, S.; Hudson, A. I.; Praud, S.; Dubreuil, P.; Tixier, M.-H.; Ross-Ibarra, J.; Runcie, D. E.
10.1101/2021.07.14.452335 — plant biology — Posted on 2021-07-15
2124 Predicting stable binding modes from simulated dimers of the D76N mutant of β2-microglobulin
Oliveira, N. F. B.; Rodrigues, F. E. P.; Vitorino, J. N. M.; Loureiro, R. J. S.; Faisca, P. F.; Machuqueiro, M.
10.1101/2021.07.14.452361 — biophysics — Posted on 2021-07-15
2125 SvAnna: efficient and accurate pathogenicity prediction for coding and regulatory structural variants in long-read genome sequencing
Danis, D.; Jacobsen, J. O. B.; Balachandran, P.; Zhu, Q.; Yilmaz, F.; Reese, J.; Haimel, M.; Mungall, C. J.; Beck, C.; Lee, C.; Smedley, D.; Robinson, P. N.
10.1101/2021.07.14.452267 — bioinformatics — Posted on 2021-07-15
2126 The E3 ligase RNF115 regulates phagosome maturation and host response to bacterial infection
Bilkei-Gorzo, O.; Heunis, T.; Fabrikova, D.; Marin Rubio, J.-L.; Peltier, J.; Oakley, F.; Härtlova, A.; Trost, M.
10.1101/2021.07.13.452284 — biochemistry — Posted on 2021-07-15
2128 Predation Efficiency upon Clinical Isolates: Bdellovibrio bacteriovorus is Prey Specific and Origin Dependent
Herencias, C.; Saralegui, C.; Halperin, A.; Caballero, J. d. D.; Perez-Viso, B.; Salgado-Briegas, S.; Fernandez-Lanza, V.; Canton, R.; Baquero, F.; Prieto, A.; del Campo, R.
10.1101/2021.07.13.452292 — ecology — Posted on 2021-07-15
2129 Implications of Spike-glycoprotein processing at S1/S2 by Furin, at S2' by Furin and/or TMPRSS2 and shedding of ACE2: cell-to-cell fusion, cell entry and infectivity of SARS-CoV-2
Essalmani, R.; Jain, J.; Susan-Resiga, D.; Andreo, U.; Evagelidis, A.; Derbali, R. M.; Huynh, D.; Dallaire, F.; Laporte, M.; Delpal, A.; Sutto-Ortiz, P.; Coutard, B.; Mapa, C.; Wilcoxen, K.; Decroly, E.; Pham, T.; Cohen, E. A.; Seidah, N. G.
10.1101/2020.12.18.423106 — biochemistry — Posted on 2021-07-15
2130 Implications of Spike-glycoprotein processing at S1/S2 by Furin, at S2' by Furin and/or TMPRSS2 and shedding of ACE2: cell-to-cell fusion, cell entry and infectivity of SARS-CoV-2
Essalmani, R.; Jain, J.; Susan-Resiga, D.; Andreo, U.; Evagelidis, A.; Derbali, M.; Huynh, D.; Dallaire, F.; Laporte, M.; Delpal, A.; Sutto-Ortiz, P.; Coutard, B.; Mapa, C.; Wilcoxen, K.; Decroly, E.; Pham, T. N.; Cohen, E. A.; Seidah, N. G.
10.1101/2021.07.02.450896 — biochemistry — Posted on 2021-07-15
2131 Defining the Immune Responses for SARS-CoV-2-Human Macrophage Interactions
Abdelmoaty, M.; Yeapuri, P.; Machhi, J.; Olson, K.; Shahjin, F.; Zhou, Y.; Jingjing, L.; Pandey, K.; Acharya, A.; Byrareddy, S.; Mosley, L.; Gendelman, H.
10.1101/2021.07.07.449660 — immunology — Posted on 2021-07-15
2132 Assessment of the evolutionary consequence of putative driver mutations in colorectal cancer with spatial multiomic data
Heide, T.; Househam, J.; Cresswell, G. D.; Spiteri, I.; Lynn, C.; Kimberley, C.; Mossner, M.; Zapata, L.; Gabbutt, C.; Ramazzotti, D.; Chen, B.; Fernandez-Mateos, J.; James, C.; Iorio, F.; Berner, A.; Schmidt, M.; Lakatos, E.; Baker, A.-M.; Nichol, D.; Costa, H.; Mitchinson, M.; Werner, B.; Jansen, M.; Barnes, C.; Caravagna, G.; Shibata, D.; Bridgewater, J.; Rodriguez-Justo, M.; Magnani, L.; Graham, T. A.; Sottoriva, A.
10.1101/2021.07.14.451265 — cancer biology — Posted on 2021-07-15
2135 USP28 deletion and small molecule inhibition destabilises c-Myc and elicits regression of squamous cell lung carcinoma
Ruiz, E. J.; Pinto-Fernandez, A.; Turnbull, A. P.; Lan, L.; Charlton, T. M.; Scott, H. C.; Damianou, A.; Vere, G.; Riising, E. M.; Da Costa, C.; Krajewski, W. W.; Guerin, D.; Kearns, J.; Ioannidis, S.; Katz, M.; McKinnon, C.; O'Connell, J. C.; Moncaut, N.; Rosewell, I.; Nye, E.; Jones, N.; Heride, C.; Gersch, M.; Wu, M.; Dinsmore, C. J.; Hammonds, T. R.; Kim, S.; Komander, D.; Urbe, S.; Clague, M. J.; Kessler, B. M.; Behrens, A.
10.1101/2020.11.17.377705 — cancer biology — Posted on 2021-07-15
2136 Novel amiloride derivatives that inhibit bacterial motility across multiple strains and stator types
Islam, M. I.; Bae, J.; Ishida, T.; Ridone, P.; Lin, J.; Kelso, M. J.; Sowa, Y.; Buckley, B. J.; Baker, M. A.
10.1101/2021.04.13.439105 — microbiology — Posted on 2021-07-15
2137 The 4.4 A structure of the giant Melbournevirus virion belonging to the Marseilleviridae family
Burton-Smith, R. N.; Reddy, H. K. N.; Svenda, M.; Abergel, C.; Okamoto, K.; Murata, K.
10.1101/2021.07.14.452405 — microbiology — Posted on 2021-07-15
2138 Long-range single-molecule mapping of chromatin modification in eukaryotes
Weng, Z.; Ruan, F.; Chen, W.; Xie, Z.; Xie, Y.; Zhang, C.; Chen, Z.; Wang, J.; Sun, Y.; Fang, Y.; Guo, M.; Tong, Y.; Li, Y.; Tang, C.
10.1101/2021.07.08.451578 — genomics — Posted on 2021-07-15
2142 Minimal DNA Electron Transfer Catalysts Switched by a Chaotropic Ion
Hoog, T. G.; Pawlak, M. R.; Aufdembrink, L. M.; Bachan, B. R.; Galles, M. B.; Bense, N. B.; Adamala, K. P.; Engelhart, A. E.
10.1101/784561 — synthetic biology — Posted on 2021-07-14
2144 Functional enrichment of alternative splicing events with NEASE reveals insights into tissue identity and diseases
Louadi, Z.; Elkjaer, M. L.; Klug, M.; Lio, C. T.; Fenn, A.; Illes, Z.; Bongiovanni, D.; Baumbach, J.; Kacprowski, T.; List, M.; Tsoy, O.
10.1101/2021.07.14.452376 — bioinformatics — Posted on 2021-07-14
2145 Three-dimensional organization of chromatin associated RNAs and their role in chromatin architecture in human cells
Calandrelli, R.; Wen, X.; Nguyen, T. C.; Chen, C.-J.; Qi, Z.; Chen, W.; Yan, Z.; Wu, W.; Zaleta-Rivera, K.; Hu, R.; Yu, M.; Wang, Y.; Ma, J.; Ren, B.; Zhong, S.
10.1101/2021.06.10.447969 — genomics — Posted on 2021-07-14
2151 The 4.4 A structure of the giant Melbournevirus virion belonging to the Marseilleviridae family
Burton-Smith, R. N.; Reddy, H. K. N.; Svenda, M.; Abergel, C.; Okamoto, K.; Murata, K.
10.1101/2021.07.14.452405 — microbiology — Posted on 2021-07-14
2155 Recording Temporal Signals with Minutes Resolution Using Enzymatic DNA Synthesis
Bhan, N. J.; Castinado, A.; Glaser, J. I.; Kalhor, R. K.; Strutz, J.; Boyden, E.; Church, G.; Kording, K. P.; Tyo, K.
10.1101/2021.07.14.452380 — synthetic biology — Posted on 2021-07-14
2158 Twisting DNA by Salt
Cruz-León, S.; Vanderlinden, W.; Müller, P.; Forster, T.; Staudt, G.; Lin, Y.-Y.; Lipfert, J.; Schwierz, N.
10.1101/2021.07.14.452306 — biophysics — Posted on 2021-07-14
2160 Distribution-based comprehensive evaluation ofmethods for differential expression analysis inmetatranscriptomics
Cho, H.; Liu, C.; Lin, B. M.; Tang, B.; Roach, J.; de Ribeiro, A.; Love, M. I.; Divaris, K.; Wu, D.
10.1101/2021.07.14.452374 — bioinformatics — Posted on 2021-07-14
2162 Palmitoylation targets the Calcineurin phosphatase to the Phosphatidylinositol 4-kinase complex at the plasma membrane
Ulengin-Talkish, I.; Parson, M. A.; Jenkins, M. L.; Roy, J.; Shih, A. Z.; St-Denis, N.; Gulyas, G.; Balla, T.; Gingras, A.-C.; Varnai, P.; Conibear, E.; Burke, J. E.; Cyert, M. S.
10.1101/2021.07.14.451536 — biochemistry — Posted on 2021-07-14
2164 Development of epigenetic clocks for New Zealand livestock
Caulton, A.; Dodds, K. G.; McRae, K. M.; Couldrey, C.; Horvath, S.; Clarke, S. M.
10.1101/2021.06.30.450497 — genomics — Posted on 2021-07-14
2165 Efficient and Economical Targeted Insertion in Plant Genomes via Protoplast Regeneration
Hsu, C.-T.; Yuan, Y.-H.; Lin, Y.-C.; Lin, S.; Cheng, Q.-W.; Wu, F.-H.; Sheen, J.; Shih, M.-C.; Lin, C.-S.
10.1101/2021.03.09.434087 — genetics — Posted on 2021-07-14
2166 Retinal ganglion cell-specific genetic regulation in primary open angle glaucoma
Daniszewski, M.; Senabouth, A.; Liang, H. H.; Han, X.; Lidgerwood, G. E.; Hernandez, D.; Sivakumaran, P.; Clarke, J. E.; Lim, S. Y.; Lees, J. G.; Rooney, L.; Gulluyan, L.; Souzeau, E.; Graham, S. L.; Chan, C.-L.; Nguyen, U.; Farbehi, N.; Gnanasambandapillai, V.; McCloy, R. A.; Clarke, L.; Kearns, L.; Mackey, D. A.; Craig, J. E. E.; MacGregor, S.; Powell, J. E.; Pebay, A.; Hewitt, A. W.
10.1101/2021.07.14.452417 — genetics — Posted on 2021-07-14
2167 The dual nature of metacommunity variability
Lamy, T.; Wisnoski, N. I.; Andrade, R. M.; Castorani, M. C.; Compagnoni, A.; Lany, N. K.; Marazzi, L.; Record, S.; Swan, C.; Tonkin, J. D.; Wang, S.; Voelker, N.; Zarnetske, P. L.; Sokol, E. R.
10.1101/2021.04.09.439168 — ecology — Posted on 2021-07-14
2169 Distinct mitochondrial remodeling during early cardiomyocyte development in a human-based stem cell model
Mostafavi, S.; Balafkan, N.; Pettersen, I. K. N.; Nido, G. S.; Siller, R.; Tzoulis, C.; Sullivan, G.; Bindoff, L. A.
10.1101/2021.07.07.451436 — cell biology — Posted on 2021-07-14
2171 The Janus-like role of neuraminidase isoenzymes in inflammation
Howlader, M. A.; Demina, E. P.; Samarani, S.; Guo, T.; Ahmad, A.; Pshezhetsky, A. V.; Cairo, C. W.
10.1101/2021.07.14.452400 — immunology — Posted on 2021-07-14
2177 Targeting KRAS-mutant stomach/colorectal tumours by disrupting the ERK2-p53 complex
Lang, J.-Y.; Wang, X.; Xie, Q.; Ji, Y.; Shen, J.; Zhang, Y.; Jiang, F.; Kong, X.; Liu, D.; Zheng, L.; Qing, C.
10.1101/2020.08.12.247460 — cancer biology — Posted on 2021-07-14
2182 Optimal Time Lags from Causal Prediction Model Help Stratify and Forecast Nervous System Pathology
Bermperidis, T.; Rai, R.; Ryu, J.; Zanotto, D.; Agrawal, S. K.; Lalwani, A. K.; Torres, E. B.
10.1101/2021.03.05.434171 — neuroscience — Posted on 2021-07-14
2183 The importance of environmentally-acquired bacterial symbionts for the squash bug (Anasa tristis), a significant agricultural pest
Acevedo, T. S.; Fricker, G. P.; Garcia, J. R.; Alcaide, T.; Berasategui, A.; Stoy, K. S.; Gerardo, N. M.
10.1101/2021.07.14.452367 — ecology — Posted on 2021-07-14
2184 Structural heterogeneity of the microtubule lattice
Guyomar, C.; Ku, S.; Heumann, J.; Bousquet, C.; Guilloux, G.; Gaillard, N.; Heichette, C.; Duchesne, L.; Steinmetz, M. O.; Gibeaux, R.; Chretien, D.
10.1101/2021.07.14.452321 — cell biology — Posted on 2021-07-14
2186 Hypoxia induces early neurogenesis in human fetal neural stem cells by activating the WNT pathway.
Dey, D.; Joshi, D.; Shrivastava, V.; Singal, C. M. S.; Tyagi, S.; Bhat, M. A.; Jaiswal, P.; Sharma, J. B.; Palanichamy, J. K.; Sinha, S.; Seth, P.; Sen, S.
10.1101/2021.07.14.452315 — neuroscience — Posted on 2021-07-14
2187 PyLipID: A Python package for analysis of protein-lipid interactions from MD simulations
Song, W.; Corey, R. A.; Ansell, B.; Cassidy, K.; Horrell, M.; Duncan, A.; Stansfeld, P. J.; Sansom, M.
10.1101/2021.07.14.452312 — biophysics — Posted on 2021-07-14
2190 Allele-resolved single-cell multi-omics uncovers the dynamics and transcriptional kinetics of X-chromosome upregulation
Lentini, A.; Cheng, H.; Noble, J. C.; Papanicolaou, N.; Coucoravas, C.; Andrews, N.; Deng, Q.; Enge, M.; Reinius, B.
10.1101/2021.07.14.452323 — genomics — Posted on 2021-07-14
2196 Mapping Human Transient Transcriptomes Using Single Nucleotide Resolution 4sU Sequencing (SNU-Seq)
Mellor, J.; Lorenz, P.; Lamstaes, A.; Fischl, H. J.; Xi, S.; Saukko-Paavola, A.; Murray, S. C.; Brown, T.; George, C.; Furger, A.; Angel, A.
10.1101/2021.07.14.452379 — molecular biology — Posted on 2021-07-14
2198 Water-soluble tocopherol derivatives inhibit SARS-CoV-2 RNA-dependent RNA polymerase
Pacl, H. T.; Tipper, J. L.; Sevalkar, R. R.; Crouse, A.; Crowder, C.; UAB Precision Medicine Institute, ; Holder, G. D.; Kuhlman, C. J.; Chinta, K. C.; Nadeem, S.; Green, T. J.; Petit, C. M.; Steyn, A. J.; Might, M.; Harrod, K. S.
10.1101/2021.07.13.449251 — microbiology — Posted on 2021-07-14
2199 Repurposing screen highlights broad-spectrum coronavirus antivirals and their host targets
Haid, S.; Matthaei, A.; Winkler, M.; Sake, S. M.; Gunesch, A. P.; Rueckert, J.; Vieyres, G.; Kuehl, D.; Nguyen, T.-T.; Lasswitz, L.; Zapatero, F.; Brogden, G.; Gerold, G.; Wiegmann, B.; Bilitewski, U.; Broenstrup, M.; Schulz, T.; Pietschmann, T.
10.1101/2021.07.14.452343 — microbiology — Posted on 2021-07-14
2201 A modular protein subunit vaccine candidate produced in yeast confers protection against SARS-CoV-2 in non-human primates
Dalvie, N. C.; Tostanoski, L. H.; Rodriguez-Aponte, S. A.; Kaur, K.; Bajoria, S.; Kumru, O.; Martinot, A. J.; Chandrashekar, A.; McMahan, K.; Mercado, N. B.; Yu, J.; Chang, A.; Giffin, V. M.; Nampanya, F.; Patel, S.; Bowman, L.; Naranjo, C. A.; Yun, D.; Flinchbaugh, Z.; Pessaint, L.; Brown, R.; Velasco, J.; Teow, E.; Cook, A.; Andersen, H.; Lewis, M. G.; Camp, D. L.; Silverman, J. M.; Kleanthous, H.; Joshi, S. B.; Volkin, D. B.; Biswas, S.; Love, J. C.; Barouch, D. H.
10.1101/2021.07.13.452251 — immunology — Posted on 2021-07-14
2204 Transcriptional regulation of neural stem cell expansion in adult hippocampus
Guo, N.; McDermott, K.; Shih, Y.-T.; Zanga, H.; Ghosh, D.; Goncalves, T.; Sahay, A.
10.1101/2021.07.14.452351 — neuroscience — Posted on 2021-07-14
2205 Spinal ganglia control nociceptive input to the central nervous system
Han, H.; Ramli, R.; Wang, C.; Liu, C.; Shah, S.; Mullen, P.; Lall, V.; Jones, F.; Shao, J.; Zhang, H.; Jaffe, D. B.; Gamper, N.; Du, X.
10.1101/2021.07.14.452325 — neuroscience — Posted on 2021-07-14
2211 DeeReCT-TSS: A novel meta-learning-based method annotates TSS in multiple cell types based on DNA sequences and RNA-seq data
Zhou, J.; Zhang, B.; Li, H.; Zhou, L.; Li, Z.; Long, Y.-K.; Han, W.; Wang, M.; Cui, H.; Chen, W.; Gao, X.
10.1101/2021.07.14.452328 — bioinformatics — Posted on 2021-07-14
2213 An exon-intron split framework to prioritize transcriptional and post-transcriptional regulatory signals and its application to study energy homeostasis in pigs
Marmol-Sanchez, E.; Cirera, S.; Zingaretti, L.; Jacobsen, M. J.; Ramayo-Caldas, Y.; Jorgensen, C. B.; Fredholm, M.; Cardoso, T. F.; Quintanilla, R.; Amills, M.
10.1101/2021.07.14.452370 — genomics — Posted on 2021-07-14
2214 Evolutionary transition to XY sex chromosomes associated with Y-linked duplication of a male hormone gene in a terrestrial isopod
Russell, A.; Borrelli, S.; Fontana, R.; Laricchiuta, J.; Pascar, J.; Becking, T.; Giraud, I.; Cordaux, R.; Chandler, C.
10.1101/2020.05.18.102079 — evolutionary biology — Posted on 2021-07-14
2216 mtDNA replication in dysfunctional mitochondria promotes deleterious heteroplasmy via the UPRmt
Yang, Q.; Liu, P.; Anderson, N.; Shpilka, T.; Du, Y.; Uma Naresh, N.; Luk, K.; Lavelle, J.; Zeinert, R.; Chien, P.; Wolfe, S.; Haynes, C.
10.1101/2020.09.01.274472 — cell biology — Posted on 2021-07-14
2217 ECM dimensionality tunes actin tension to modulate the endoplasmic reticulum and spheroid phenotype
Kai, F.; Ou, G.; Tourdot, R. W.; Stashko, C.; Gaietta, G.; Swift, M. F.; Volkmann, N.; Long, A. F.; Han, Y.; Huang, H. H.; Northey, J. J.; Leidal, A. M.; Viasnoff, V.; Bryant, D. M.; Guo, W.; Wiita, A. P.; Guo, M.; Dumont, S.; Hanein, D.; Radhakrishnan, R.; Weaver, V. M.
10.1101/2021.07.14.452329 — cell biology — Posted on 2021-07-14
2218 The role of cytosolic polyadenylation element binding protein 2 alternative splicing in hypoxia
Mayo, E. M.; Stevens, S. C.; Ali, A. N.; Moss, C. J.; Lund, S. P.; Nazario-Munoz, G. S.; Chalfant, C. E.; Permuth, J. B.; Westerheide, S. D.; Park, M. A.
10.1101/2020.10.05.325290 — cell biology — Posted on 2021-07-14
2220 hnRNPA1 regulates early translation to replication switch in SARS-CoV-2 life cycle
Kumar, R.; Chander, Y.; Khandelwal, N.; Nagori, H.; Verma, A.; Pal, Y.; Gulati, B. R.; Tripathi, B. N.; Barua, S.; Kumar, N.
10.1101/2021.07.13.452288 — microbiology — Posted on 2021-07-14
2221 Adaptation, spread and transmission of SARS-CoV-2 in farmed minks and related humans in the Netherlands
Lu, L.; Sikkema, R. S.; Velkers, F. C.; Nieuwenhuijse, D. F.; Fischer, E. A. J.; Meijer, P. A.; Bouwmeester-Vincken, N.; Rietveld, A.; Wegdam-Blans, M. C. A.; Tolsma, P.; Koppelman, M.; Smit, L. A. M.; Hakze-van der Honing, R. W.; van der Poel, W. H. M.; van der Spek, A. N.; Spierenburg, M. A. H.; Molenaar, R. J.; de Rond, J.; Augustijn, M.; Woolhouse, M.; Stegeman, A. J.; Lycett, S.; Oude Munnink, B. B.; Koppelman, M. P. G.
10.1101/2021.07.13.452160 — microbiology — Posted on 2021-07-14
2222 Human placental villi immune cells help maintain homeostasis in utero
Konnikova, L.; Toothaker, J. M.; Olaloye, O.; McCourt, B. T.; McCourt, C. C.; Case, R. M.; Liu, P.; Yimlamai, D.; Tseng, G.
10.1101/2021.07.14.452362 — immunology — Posted on 2021-07-14
2223 Balanced release of neuropeptide FF and gonadotropin-releasing hormone 3 modulates male sexual behavior
Umatani, C.; Yoshida, N.; Yamamoto, E.; Akazome, Y.; Mori, Y.; Kanda, S.; Okubo, K.; Oka, Y.
10.1101/2021.07.14.452327 — neuroscience — Posted on 2021-07-14
2224 Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties
Riguet, N.; Mahul-Mellier, A.-L.; Maharjan, N.; Burtscher, J.; Croisier, M.; Knott, G. W.; Hastings, J.; Patin, A.; Reiterer, V.; Farhan, H.; Nazarov, S.; Lashuel, H.
10.1101/2020.07.29.226977 — neuroscience — Posted on 2021-07-14
2225 Striatal fiber photometry reflects primarily non-somatic activity
Legaria, A. A.; Yang, B.; Ahanonu, B.; Licholai, J. A.; Parker, J.; Kravitz, A.
10.1101/2021.01.20.427525 — neuroscience — Posted on 2021-07-14
2228 Achieving dendritic cell subset-specific targeting in vivo by site-directed conjugation of targeting antibodies to nanocarriers
Simon, J.; Fichter, M.; Kuhn, G.; Brueckner, M.; Kappel, C.; Schunke, J.; Grabbe, S.; Landfester, K.; Mailaender, V.
10.1101/2021.07.14.452311 — bioengineering — Posted on 2021-07-14
2230 The haplotype-resolved reference genome of lemon (Citrus limon L. Burm f.)
Di Guardo, M.; Moretto, M.; Moser, M.; Catalano, C.; Troggio, M.; Deng, Z.; Cestaro, A.; Caruso, M.; Distefano, G.; La Malfa, S.; Bianco, L.; Gentile, A.
10.1101/2021.07.14.452308 — genomics — Posted on 2021-07-14
2232 The J domain of sacsin disrupts intermediate filament assembly
Dabbaghizadeh, A.; Pare, A.; Cheng-Boivin, Z.; Dagher, R.; Minotti, S.; Dicaire, M.-J.; Brais, B.; Young, J. C.; Durham, H. D.; Gentil, B. J.
10.1101/2021.07.14.452331 — cell biology — Posted on 2021-07-14
2234 A cost-effective and efficient approach for generating and assembling reagents for conducting real-time PCR
Mote, R. D.; V, S. L.; Singh, S. B.; Tiwari, M.; Singh, H.; Srivastava, J.; Tripathi, V.; Seshadri, V.; Majumdar, A.; Subramanyam, D.
10.1101/2021.07.14.452300 — molecular biology — Posted on 2021-07-14
2235 RNase HI depletion strongly potentiates cell killing by rifampicin in mycobacteria
Al-Zubaidi, A.; Cheung, C.-Y.; Cook, G. M.; Taiaroa, G.; Mizrahi, V.; Lott, J. S.; Dawes, S. S.
10.1101/2021.07.14.452003 — microbiology — Posted on 2021-07-14
2236 Regulation of MHC-I and MHC-II by CIITA in transmissible cancers
Ong, C. E. B.; Cheng, Y.; Siddle, H.; Lyons, A. B.; Woods, G. M.; Flies, A. S.
10.1101/2021.07.14.452299 — immunology — Posted on 2021-07-14
2237 Differential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment
Guma, E.; Bordeleau, M.; Snook, E.; Desrosiers-Gregoire, G.; Gonzalez Ibanez, F.; Picard, K.; Spring, S.; Lerch, J. P.; Nieman, B. J.; Devenyi, G. A.; Tremblay, M.-E.; Chakravarty, M. M.
10.1101/2021.07.14.452084 — neuroscience — Posted on 2021-07-14
2240 Making Strides in Doctoral-Level Career Outcomes Reporting: Surveying the Landscape of Classification and Visualization Methodologies and Creating a Crosswalk Tool
Collins, T.; Ramadoss, D.; Layton, R.; MacDonald, J.; Wheeler, R.; Bankston, A.; Stayart, C. A.; Hao, Y.; Robinson-Hamm, J.; Sinche, M.; Burghart, S.; Carlsen-Bryan, A.; Eswara, P.; Krasna, H.; Xu, H.; Sullivan, M.
10.1101/2021.07.12.451657 — scientific communication and education — Posted on 2021-07-14
2241 Assessment of the evolutionary consequence of putative driver mutations in colorectal cancer with spatial multiomic data
Sottoriva, A.; Graham, T. A.; Heide, T.; Househam, J.; Cresswell, G. D.; Spiteri, I.; Lynn, C.; Kimberley, C.; Mossner, M.; Zapata, L.; Gabbutt, C.; Ramazzotti, D.; Chen, B.; Fernandez-Mateos, J.; James, C.; Iorio, F.; Berner, A.; Schmidt, M.; Lakatos, E.; Baker, A.-M.; Nichol, D.; Costa, H.; Mitchinson, M.; Werner, B.; Jansen, M.; Barnes, C.; Caravagna, G.; Shibata, D.; Bridgewater, J.; Rodriguez-Justo, M.; Magnani, L.
10.1101/2021.07.14.451265 — cancer biology — Posted on 2021-07-14
2243 Design of complicated all-α protein structures
Sakuma, K.; Kobayashi, N.; Sugiki, T.; Nagashima, T.; Fujiwara, T.; Suzuki, K.; Kobayashi, N.; Murata, T.; Kosugi, T.; Koga, R.; Koga, N.
10.1101/2021.07.14.449347 — biophysics — Posted on 2021-07-14
2252 An osmotic laxative renders mice susceptible to prolonged Clostridioides difficile colonization and hinders clearance
Tomkovich, S.; Taylor, A.; King, J.; Colovas, J.; Bishop, L.; McBride, K.; Royzenblat, S.; Lesniak, N. A.; Bergin, I. L.; Schloss, P. D.
10.1101/2021.07.13.452287 — microbiology — Posted on 2021-07-14
2253 Trophic status and local conditions affect microbial potential for denitrification versus internal nitrogen cycling in lake sediments
Baumann, K. B. L.; Thoma, R.; Callbeck, C. M.; Niederdorfer, R.; Schubert, C.; Müller, B.; Lever, M. A.; Bürgmann, H.
10.1101/2021.07.12.452135 — microbiology — Posted on 2021-07-14
2256 Perturb-map enables CRISPR genomics with spatial resolution and identifies regulators of tumor immune composition
Dhainaut, M.; Rose, S. A.; Akturk, G.; Wroblewska, A.; Sook Park, E.; Nielsen, S. R.; Buckup, M.; Roudko, V.; Pia, L.; Le Berichel, J.; Bektesevic, A.; Lee, B. H.; Baccarini, A.; Bhardwaj, N.; Rahman, A. H.; Gnjatic, S.; Pe'er, D.; Merad, M.; Brown, B. D.
10.1101/2021.07.13.451021 — immunology — Posted on 2021-07-14
2257 Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease
Xia, Z.; Prescott, E.; Leah, T.; Dakin, H.; Dimou, E.; Zuo, Y.; Zhang, Y. P.; Lam, J. Y. L.; Danial, J. S. H.; Jiang, H.; Mortiboys, H. J.; Thornton, P.; Crowther, D. C.; Holtzman, D. M.; Ranasinghe, R. T.; Klenerman, D.; De, S.
10.1101/2021.07.13.452239 — neuroscience — Posted on 2021-07-14
2259 Effects of sub-threshold transcutaneous auricular vagus nerve stimulation on cerebral blood flow
Chen, C.; Mao, Y.; Falahpour, M.; MacNiven, K. H.; Heit, G.; Sharma, V.; Alataris, K.; Liu, T. T.
10.1101/2021.07.13.451709 — neuroscience — Posted on 2021-07-14
2261 Cortical cell ensemble control of past experience-dependent memory updating
Suzuki, A.; Kosugi, S.; Murayama, E.; Sasakawa, E.; Ohkawa, N.; Konno, A.; Hirai, H.; Inokuchi, K.
10.1101/2021.07.13.452275 — neuroscience — Posted on 2021-07-14
2262 Metabolic endotoxemia is dictated by the type of lipopolysaccharide
Anhe, F. F.; Barra, N. G.; Cavallari, J. F.; Henriksbo, B. D.; Schertzer, J.
10.1101/2021.07.13.452270 — physiology — Posted on 2021-07-14
2264 Caveolin-1 temporal modulation enhances trastuzumab and trastuzumab-drug conjugate efficacy in heterogeneous gastric cancer
Pereira, P. M. R.; Mandleywala, K.; Monette, S.; Lumish, M.; Tully, K. M.; Cornejo, M.; Mauguen, A.; Ragupathi, A.; Mattar, M.; Janjigian, Y. Y.; Lewis, J. S.
10.1101/2021.07.13.452260 — cancer biology — Posted on 2021-07-14
2267 CLPTM1L is a lipid scramblase involved in glycosylphosphatidylinositol biosynthesis
Wang, Y.; Menon, A. K.; Maki, Y.; Liu, Y.-S.; Iwasaki, Y.; Fujita, M.; Guerrero, P. A.; Silva, D. V.; Seeberger, P. H.; Murakami, Y.; Kinoshita, T.
10.1101/2021.07.12.451801 — biochemistry — Posted on 2021-07-14
2268 A hyperthermoactive-Cas9 editing tool reveals the role of a unique arsenite methyltransferase in the arsenic resistance system of Thermus thermophilus HB27
Gallo, G.; Mougiakos, I.; Bianco, M.; Carbonaro, M.; Carpentieri, A.; Illiano, A.; Pucci, P.; Bartolucci, S.; van der Oost, J.; Fiorentino, G.
10.1101/2021.07.12.452139 — biochemistry — Posted on 2021-07-14
2270 A Lethal Genetic Incompatibility between Naturally Hybridizing Species in Mitochondrial Complex I
Moran, B. M.; Payne, C. Y.; Powell, D. L.; Iverson, E. N.; Banerjee, S. M.; Langdon, Q. K.; Gunn, T. R.; Liu, F.; Matney, R.; Singhal, K.; Leib, R. D.; Hernandez-Perez, O.; Corbett-Detig, R.; Schartl, M.; Havird, J. C.; Schumer, M.
10.1101/2021.07.13.452279 — evolutionary biology — Posted on 2021-07-14
2272 Mapping the subcortical connectivity of the human default mode network
Li, J.; Curley, W. H.; Guerin, B.; Dougherty, D. D.; Dalca, A. V.; Fischl, B.; Horn, A.; Edlow, B. L.
10.1101/2021.07.13.452265 — neuroscience — Posted on 2021-07-14
2273 Cellular resolution anatomical and molecular atlases for prenatal human brains
Ding, S.-L.; Royall, J. J.; Lesnar, P.; Facer, B. A. C.; Smith, K. A.; Wei, Y.; Brouner, K.; Dalley, R. A.; Dee, N.; Dolbeare, T. A.; Ebbert, A.; Glass, I. A.; Glattfelter, K.; Keller, N. H.; Lee, F.; Lemon, T. A.; Nyhus, J.; Pendergraft, J.; Reid, R.; Sarreal, M.; Shapovalova, N. V.; Szafer, A.; Phillips, J. W.; Sunkin, S. M.; Hohmann, J. G.; Jones, A. R.; Hawrylycz, M. J.; Hof, P. R.; Ng, L.; Bernard, A.; Lein, E. S.
10.1101/2021.07.14.452297 — neuroscience — Posted on 2021-07-14
2276 Global change differentially modulates coral physiology and suggests future shifts in Caribbean reef assemblages
Bove, C. B.; Davies, S. W.; Ries, J. B.; Umbanhowar, J.; Thomasson, B. C.; Farquhar, E. B.; McCoppin, J. A.; Castillo, K. D.
10.1101/2021.07.13.452173 — ecology — Posted on 2021-07-14
2279 Motor memories of object dynamics are categorically organized
Cesanek, E.; Zhang, Z.; Ingram, J. N.; Wolpert, D. M.; Flanagan, J. R.
10.1101/2021.07.13.452183 — neuroscience — Posted on 2021-07-14
2281 PD-1 in hippocampal neurons regulates excitability, synaptic plasticity, and cognition
Zhao, J.; Bang, S.; McGinnis, A.; Furutani, K.; Jiang, C.; Roberts, A.; Donnelly, C. R.; He, Q.; Ko, M.-C.; Wang, H.; Palmiter, R.; Ji, R.-R.
10.1101/2021.07.13.451894 — neuroscience — Posted on 2021-07-14
2284 Nuclear Factor I in neurons, glia and during the formation of Muller glia-derived progenitor cells in avian, porcine and primate retinas
El-Hodiri, H.; Campbell, W.; Kelly, L.; Hawthorn, E.; Schwartz, M.; jalligampala, a.; McCall, M.; Meyer, K.; Fischer, A. J.
10.1101/2021.07.13.451621 — neuroscience — Posted on 2021-07-14
2286 gpuZoo: Cost-effective estimation of gene regulatory networks using the Graphics Processing Unit
Ben Guebila, M.; Morgan, D. C.; Glass, K.; Kuijjer, M. L.; DeMeo, D. L.; Quackenbush, J.
10.1101/2021.07.13.452214 — systems biology — Posted on 2021-07-14
2288 Image-based assessment of plant disease progression identifies new genetic loci for resistance
Meline, V.; Caldwell, D.; Kim, B.-S. S.; Baireddy, S.; Yang, C.; Sparks, E. E.; Delp, E. J.; Iyer-Pascuzzi, A. S.
10.1101/2021.07.13.452064 — plant biology — Posted on 2021-07-14
2289 Engineering sorghum for higher 4-hydroxybenzoic acid content
Lin, C.-Y.; Tian, Y.; Nelson-Vasilchik, K.; Hague, J.; Kakumanu, R.; Lee, M. Y.; Trinh, J.; Northen, T.; Baidoo, E.; Kausch, A.; Scheller, H.; Eudes, A.
10.1101/2021.07.13.452095 — plant biology — Posted on 2021-07-14
2291 Dual effects of presynaptic membrane mimetics on α-synuclein amyloid aggregation
Lin, Y.; Ito, D.; Yoo, J. M.; Lim, M. H.; Yu, W. K.; Kawata, Y.; Lee, Y.-H.
10.1101/2021.07.13.452016 — biophysics — Posted on 2021-07-14
2293 Capsaicin alters human NaV1.5 mechanosensitivity
Cowan, L. M.; Strege, P. R.; Rusinova, R.; Andersen, O. S.; Beyder, A.; Farrugia, G.
10.1101/2021.07.13.452086 — biophysics — Posted on 2021-07-14
2296 MetaFun: Unveiling sex differences in multiple omics studies through comprehensive functional meta-analysis
Malmierca-Merlo, P.; Sanchez-Garcia, R.; Grillo-Risco, R.; Perez-Diez, I.; Catala-Senent, J. F.; de la Iglesia-Vaya, M.; Hidalgo, M. R.; Garcia-Garcia, F.
10.1101/2021.07.13.451905 — bioinformatics — Posted on 2021-07-14
2299 Prolactin and prolactin receptor expression in the HPG axis and crop sac during parental care in both sexes of a biparental bird (Columba livia)
Farrar, V. S.; Harris, R. M.; Austin, S. H.; Nava Ultreras, B. M.; Booth, A. M.; Angelier, F.; Lang, A.; Feustel, T.; Lee, C.; Bond, A.; MacManes, M. D.; Calisi, R. M.
10.1101/2021.07.13.452208 — animal behavior and cognition — Posted on 2021-07-14
2300 Equatorial to Polar genomic variability of the microalgae Bathycoccus prasinos
Leconte, J.; Timsit, Y.; Delmont, T. O.; Lescot, M.; Piganeau, G.; Wincker, P.; Jaillon, O.
10.1101/2021.07.13.452163 — genomics — Posted on 2021-07-14
2301 Active enhancers strengthen TAD insulation by bRNA mediated CTCF enrichment at the TAD boundaries
Islam, Z.; Saravanan, B.; Walavalkar, K.; Farooq, U.; Singh, A. K.; Thakur, J.; Pandit, A.; Sabarinathan, R.; Henikoff, S.; Notani, D.
10.1101/2021.07.13.452118 — genomics — Posted on 2021-07-14
2304 Benchmarking ultra-high molecular weight DNA preservation methods for long-read and long-range sequencing
Dahn, H. A.; Mountcastle, J.; Balacco, J.; Winkler, S.; Bista, I.; Schmitt, A. D.; Vinnere Pettersson, O.; Formenti, G.; Oliver, K.; Smith, M.; Tan, W.; Kraus, A.; Mac, S.; Komoroske, L. M.; Lama, T.; Crawford, A. J.; Murphy, R. W.; Brown, S.; Scott, A. F.; Morin, P. A.; Jarvis, E. D.; Fedrigo, O.
10.1101/2021.07.13.451380 — genomics — Posted on 2021-07-14
2307 Pulling on multiple threads of evidence to reveal tree species coexistence
McNickle, G. G.; Ritzi, M. V.; Blackstone, K. M. S.; Couture, J. J.; Nelson, T.; Hardiman, B. S.; Montague, M. S.; Jacobs, D. F.
10.1101/2021.07.13.452199 — ecology — Posted on 2021-07-14
2308 The roles of NADPH oxidases during adult zebrafish fin regeneration
Chopra, K.; Folkmanaite, M.; Stockdale, L.; Shathish, V.; Ishibashi, S.; Bergin, R.; Amich, J.; Amaya, E.
10.1101/2021.07.13.452203 — developmental biology — Posted on 2021-07-14
2309 IL7R is required for hematopoietic stem cell reconstitution of tissue-resident lymphoid cells
Worthington, A. K.; Cool, T. S.; Poscablo, D. M.; Hussaini, A.; Beaudin, A. E.; Forsberg, E. C.
10.1101/2021.07.13.452134 — cell biology — Posted on 2021-07-14
2310 The ternary complex CEP90, FOPNL and OFD1 specifies the future location of centriolar distal appendages, and promotes their assembly
Le Borgne, P.; Laporte, M. H.; Greibill, L.; Lemullois, M.; Temagoult, M.; Rosnet, O.; Le Guennec, M.; Lignieres, L.; Chevreux, G.; Koll, F.; Hamel, V.; Guichard, P.; Tassin, A.-M.
10.1101/2021.07.13.452210 — cell biology — Posted on 2021-07-14
2313 Long-read transcriptome sequencing analysis with IsoTools
Lienhard, M.; van den Beucken, T.; Claiment, F.; Boerno, S.; Hochradel, M.; Timmermann, B.; Vingron, M.; Herwig, R.
10.1101/2021.07.13.452091 — genetics — Posted on 2021-07-14
2314 Neo-sex chromosome evolution shapes sex-dependent asymmetrical introgression barrier
Wang, S.; Nalley, M. J.; Chatla, K.; Aldaimalani, R.; MacPherson, A.; Wei, K.; Corbett, R.; Mai, D.; Bachtrog, D.
10.1101/2021.07.13.452191 — evolutionary biology — Posted on 2021-07-14
2318 Long-read isoform sequencing reveals tissue-specific isoform expression between active and hibernating brown bears (Ursus arctos)
Tseng, E.; Underwood, J. G.; Evans Hutzenbiler, B. D.; Trojahn, S.; Kingham, B.; Shevchenko, O.; Bernberg, E.; Robbins, C. T.; Jansen, H. T.; Kelley, J. L.
10.1101/2021.07.13.452179 — genomics — Posted on 2021-07-14
2319 Substrate, temperature, and geographical patterns among nearly 2,000 natural yeast isolates
Spurley, W. J.; Fisher, K. J.; Langdon, Q. K.; Buh, K. V.; Jarzyna, M.; Haase, M. A. B.; Sylvester, K.; Moriarty, R. V.; Rodriguez, D.; Sheddan, A.; Wright, S.; Sorlie, L.; Hulfachor, A. B.; Opulente, D. A.; Hittinger, C. T.
10.1101/2021.07.13.452236 — ecology — Posted on 2021-07-14
2322 A patient-driven clinicogenomic partnership through the Metastatic Prostate Cancer Project
Crowdis, J.; Balch, S.; Sterlin, L.; Thomas, B. S.; Camp, S. Y.; Dunphy, M.; Anastasio, E.; Shah, S.; Damon, A. L.; Ramos, R.; Sosa, D. M.; Small, I. K.; Tomson, B.; Nguyen, C. M.; McGillicuddy, M.; Chastain, P. S.; He, M. X.; Cheung, A. T. M.; Wankowicz, S.; Tewari, A. K.; Kim, D.; AlDubayan, S. H.; Dowdye, A.; Zola, B.; Nowak, J.; Manarite, J.; Gunn, I. H.; Olson, B.; Lander, E. S.; Painter, C. A.; Wagle, N.; Van Allen, E. M.
10.1101/2021.07.09.451849 — cancer biology — Posted on 2021-07-14
2324 Inulin nanostructures: The sweet-spot of carbohydrate self-assembly
Arnon, Z. A.; Grabarics, M.; Kreiser, T.; Raveh, A.; Pagel, K.; Gazit, E.
10.1101/2021.07.13.451276 — biophysics — Posted on 2021-07-14
2325 NOMA: a high-throughput microchip for robust, sequential measurements of secretions from the same single-cells
Liu, M.; Ji, Y.; Zhu, F.; Bai, X.; Li, L.; Xie, H.; Wei, Y.; Liu, X.; Luo, Y.; Liu, T.; Lin, B.; Lu, Y.
10.1101/2021.01.21.427049 — bioengineering — Posted on 2021-07-14
2326 Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation
Rousova, D.; Nivsarkar, V.; Altmannova, V.; Funk, S. K.; Raina, V. B.; Liedtke, D.; Janning, P.; Mueller, F.; Reichle, H.; Vader, G.; Weir, J. R.
10.1101/2020.07.30.228908 — biochemistry — Posted on 2021-07-14
2331 Local predictors of anti-Aβ therapy efficacy revealed by quantitative whole-brain microscopy
Kirschenbaum, D.; Voigt, F.; Dadgar-Kiani, E.; Catto, F.; Trevisan, C.; Bichsel, O.; Shirani, H.; Nilsson, P. K. R.; Frontzek, K.; Paganetti, P.; Helmchen, F.; Lee, J. H.; Aguzzi, A.
10.1101/2021.01.15.426090 — neuroscience — Posted on 2021-07-14
2335 Single Serine on TSC2 Exerts Biased Control over mTORC1 Activation by ERK1/2 but Not Akt
Dunkerly-Eyring, B. L.; Pinilla-Vera, M.; McKoy, D.; Mishra, S.; Grajeda Martinez, M. I.; Oeing, C. U.; Ranek, M. J.; Kass, D. A.
10.1101/2021.07.13.452249 — cell biology — Posted on 2021-07-14
2336 CellProfiler 4: Improvements in Speed, Utility and Usability
Stirling, D. R.; Swain-Bowden, M. J.; Lucas, A. M.; Carpenter, A. E.; Cimini, B. A.; Goodman, A.
10.1101/2021.06.30.450416 — cell biology — Posted on 2021-07-14
2337 NSUN2-mediated m5C methylation of IRF3 mRNA negatively regulates type I interferon responses
Wang, H.; Zhang, L.; Zeng, C.; Feng, J.; Wang, D.; He, M.; Jiang, A.; Cao, Y.; Guo, X.; Liu, J.; Yan, K.; Tang, H.; Xu, K.; Fan, C.; Guo, D.; Lan, K.; Zhou, Y.; Chen, Y.
10.1101/2021.07.09.451748 — immunology — Posted on 2021-07-14
2338 Slow Cortical Waves through Cyclicity Analysis
Abraham, I.; Shahsavarani, B.; Zimmerman, B.; Husain, F.; baryshnikov, y.
10.1101/2021.05.16.444387 — neuroscience — Posted on 2021-07-14
2342 Morphological integration during postnatal ontogeny: implications for evolutionary biology
Hubbe, A.; Garcia, G.; Sebastiao, H.; Porto, A.; Machado, F. A.; Cheverud, J.; Marroig, G.
10.1101/2021.07.13.452198 — developmental biology — Posted on 2021-07-13
2344 ATP-Independent Nucleosome Unfolding by FACT: Electron Microscopy Analysis
Sivkina, A. L.; Karlova, M. G.; Valieva, M. E.; McCullough, L.; Formosa, T.; Shaytan, A. K.; Feofanov, A. V.; Kirpichnikov, M. P.; Sokolova, O. S.; Studitsky, V. M.
10.1101/2021.07.13.452273 — molecular biology — Posted on 2021-07-13
2345 Imaging and single cell sequencing analyses of super-enhancer activation mediated by NF-κB in B cells
Wibisana, J. N.; Inaba, T.; Shinohara, H.; Yumoto, N.; Hayashi, T.; Umeda, M.; Ebisawa, M.; Nikaido, I.; Sako, Y.; Okada, M.
10.1101/2021.07.13.452147 — molecular biology — Posted on 2021-07-13
2346 Disentangling environmental effects in microbial association networks
Deutschmann, I. M.; Lima-Mendez, G.; Krabberod, A. K.; Raes, J.; Vallina, S. M.; Faust, K.; Logares, R.
10.1101/2021.07.13.452182 — microbiology — Posted on 2021-07-13
2347 Searching for Consistent Brain Network Topologies Across the Garden of (Shortest) Forking Paths
Luppi, A. I.; Gellersen, H. M.; Peattie, A. R. D.; Manktelow, A. E.; Menon, D.; Dimitriadis, S. I.; Stamatakis, E. A.
10.1101/2021.07.13.452257 — neuroscience — Posted on 2021-07-13
2348 MSA Transformer
Rao, R. M.; Liu, J.; Verkuil, R.; Meier, J.; Canny, J.; Abbeel, P.; Sercu, T.; Rives, A.
10.1101/2021.02.12.430858 — synthetic biology — Posted on 2021-07-13
2350 Structural insight into the dual function of LbpB in mediating Neisserial pathogenesis
Noinaj, N.; Yadav, R.; Govindan, S.; Daczkowski, C.; Mesecar, A.; Chakravarthy, S.
10.1101/2021.07.13.452223 — biophysics — Posted on 2021-07-13
2353 Divergence in dimerization and activity of primate APOBEC3C
Gaba, A.; Hix, M. A.; Suhail, S.; Flath, B.; Boysan, B.; Williams, D. R.; Pelletier, T.; Emerman, M.; Morcos, F.; Cisneros, G. A.; Chelico, L.
10.1101/2021.07.13.452235 — biochemistry — Posted on 2021-07-13
2354 Climate and mountains shaped human ancestral genetic lineages
Maisano Delser, P.; Krapp, M.; Beyer, R.; Jones, E.; Miller, E. F.; Hovhannisyan, A.; Parker, M.; Siska, V.; Vizzari, M. T.; Pearmain, E. J.; Imaz-Rosshandler, I.; Leonardi, M.; Somma, G. L.; Hodgson, J.; Tysall, E.; Xue, Z.; Cassidy, L.; Bradley, D. G.; Eriksson, A.; Manica, A.
10.1101/2021.07.13.452067 — genomics — Posted on 2021-07-13
2355 Towards a Comprehensive Variation Benchmark for Challenging Medically-Relevant Autosomal Genes
Wagner, J.; Olson, N. D.; Harris, L.; McDaniel, J.; Cheng, H.; Fungtammasan, A.; Hwang, Y.-C.; Gupta, R.; Wenger, A. M.; Rowell, W. J.; Khan, Z. M.; Farek, J.; Zhu, Y.; Pisupati, A.; Mahmoud, M.; Xiao, C.; Yoo, B.; Sahraeian, S. M. E.; Miller, D. E.; Jaspez, D.; Lorenzo-Salazar, J. M.; Munoz-Barrera, A.; Rubio-Rodriguez, L. A.; Flores, C.; Narzisi, G.; Evani, U. S.; Clarke, W. E.; Lee, J.; Mason, C. E.; Lincoln, S. E.; Miga, K. H.; Ebbert, M. T.; Shumate, A.; Li, H.; Chin, C.-S.; Zook, J. M.; Sedlazeck, F. J.
10.1101/2021.06.07.444885 — genomics — Posted on 2021-07-13
2360 Chromosome-level genome assembly of a human fungal pathogen reveals synteny among geographically distinct species
Voorhies, M.; Cohen, S.; Shea, T. P.; Petrus, S.; Munoz, J. F.; Poplawski, S.; Goldman, W. E.; Michael, T. P.; Cuomo, C. A.; Sil, A.; Beyhan, S.
10.1101/2021.07.13.452254 — microbiology — Posted on 2021-07-13
2364 Transcriptomic changes highly similar to Alzheimer's disease are observed in a subpopulation of individuals during normal brain aging
Peng, S.; Zeng, L.; Haure-mirande, J.-v.; Wang, M.; Huffman, D. M.; Haroutunian, V.; Ehrlich, M.; Zhang, B.; Tu, Z.
10.1101/2021.06.01.446628 — neuroscience — Posted on 2021-07-13
2365 Metabolic resilience is encoded in genome plasticity
Agudelo, L. Z.; Tuyeras, R. V.; Llinares, C.; Morcuende, A.; Park, Y.; Sun, N.; Kuosmanen, S. M.; Atabaki-Pasdar, N.; Ho, L.-L.; Galani, K.; Franks, P. W.; Kutlu, B.; Grove, K.; Femenia, T.; Kellis, M.
10.1101/2021.06.25.449953 — systems biology — Posted on 2021-07-13
2368 Ribovore: ribosomal RNA sequence analysis for GenBank submissions and database curation
Schäffer, A. A.; McVeigh, R.; Robbertse, B.; Schoch, C. L.; Johnston, A.; Underwood, B. A.; Karsch-Mizrachi, I.; Nawrocki, E. P.
10.1101/2021.02.11.430762 — bioinformatics — Posted on 2021-07-13
2371 De novo macrocyclic peptides for inhibiting, stabilising and probing the function of the Retromer endosomal trafficking complex
Chen, K.-E.; Guo, Q.; Hill, T. A.; Cui, Y.; Kendall, A. K.; Yang, Z.; Hall, R. J.; Healy, M.; Sacharz, J.; Norwood, S. J.; Fonseka, S.; Xie, B.; Reid, R. C.; Leneva, N.; Parton, R. G.; Ghai, R.; Stroud, D. A.; Fairlie, D. P.; Suga, H.; Jackson, L. P.; Teasdale, R. D.; Passioura, T.; Collins, B. M.
10.1101/2020.12.03.410779 — biochemistry — Posted on 2021-07-13
2372 Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation
Rousova, D.; Nivsarkar, V.; Altmannova, V.; Funk, S. K.; Raina, V. B.; Liedtke, D.; Janning, P.; Mueller, F.; Reichle, H.; Vader, G.; Weir, J. R.
10.1101/2020.07.30.228908 — biochemistry — Posted on 2021-07-13
2374 Megapixel camera arrays for high-resolution animal tracking in multiwell plates
Barlow, I.; Feriani, L.; Minga, E.; McDermott-Rouse, A.; O'Brien, T.; Liu, Z.; Hofbauer, M.; Stowers, J. R.; Andersen, E.; Ding, S. S.; Brown, A. E.
10.1101/2021.04.16.440222 — animal behavior and cognition — Posted on 2021-07-13
2375 Optimized Cas9 expression improves performance of large-scale CRISPR screening
Fernandes Neto, J. M.; Jastrzebski, K.; Lieftink, C.; Krenning, L.; Dias, M.; Morris, B.; van der Ven, D.; Heimans, H.; Medema, R. H.; Bernards, R.; Beijersbergen, R. L.
10.1101/2021.07.13.452178 — genomics — Posted on 2021-07-13
2379 Myonuclear maturation dynamics in aged and adult regenerating mouse skeletal muscle
Kurland, J. V.; Deusen, A. V.; Pawlikowski, B.; Hall, M.; Betta, N. D.; Antwine, T.; Cutler, A. A.; Russell, A.; Allen, M. A.; Dowell, R. D.; Olwin, B. B.
10.1101/2021.07.13.452218 — molecular biology — Posted on 2021-07-13
2380 Co-translational assembly counteracts promiscuous interactions
Seidel, M.; Becker, A.; Pereira, F.; Landry, J. J. M.; Trevisan Doimo de Azevedo, N.; Fusco, C. M.; Kaindl, E.; Baumbach, J.; Langer, J. D.; Schuman, E. M.; Patil, K. R.; Hummer, G.; Benes, V.; Beck, M.
10.1101/2021.07.13.452229 — molecular biology — Posted on 2021-07-13
2382 The Bardet-Biedl protein Bbs1 controls photoreceptor outer segment protein and lipid composition
Masek, M.; Etard, C.; Hofmann, C.; Huelsmeier, A.; Zang, J.; Takamiya, M.; Gesemann, M.; Neuhauss, S. C.; Hornemann, T.; Straehle, U.; Bachmann-Gagescu, R.
10.1101/2021.07.13.452166 — molecular biology — Posted on 2021-07-13
2384 Bacterial microcompartments for isethionate desulfonation in the taurine-degrading human-gut bacterium Bilophila wadsworthia
Burrichter, A. G.; Doerr, S.; Bergmann, P.; Haiss, S.; Keller, A.; Fournier, C.; Franchini, P.; Isono, E.; Schleheck, D.
10.1101/2021.07.13.451622 — microbiology — Posted on 2021-07-13
2386 The Burkholderia cenocepacia type VI secretion system effector TecA is a virulence factor during lung infection
Loeven, N. A.; Perault, A. I.; Cotter, P. A.; Hodges, C. A.; Schwartzman, J. D.; Hampton, T. H.; Bliska, J. B.
10.1101/2021.07.13.451912 — microbiology — Posted on 2021-07-13
2387 Metabolic regulation of ILC2 differentiation into ILC1-like cells during Mycobacterium tuberculosis infection
Hudrisier, D.; Corral, D.; Charton, A.; Krauss, M. Z.; Blanquart, E.; Levillain, F.; Lefrancais, E.; Sneperger, T.; Girard, J.-P.; Eberl, G.; Poquet, Y.; Guery, J.-C.; Arguello, R. J.; Hepworth, M. R.; Neyrolles, O.
10.1101/2021.01.19.427257 — immunology — Posted on 2021-07-13
2390 The role of reading experience in atypical cortical tracking of speech and speech-in-noise in dyslexia
Destoky, F.; Bertels, J.; Niesen, M.; Wens, V.; Vander Ghinst, M.; Rovai, A.; Trotta, N.; Lallier, M.; De Tiege, X.; Bourguignon, M.
10.1101/2021.07.13.452155 — neuroscience — Posted on 2021-07-13
2391 Prediction Errors Disrupt Hippocampal Representations and Update Episodic Memories
Sinclair, A. H.; Manalili, G. M.; Brunec, I. K.; Adcock, R. A.; Barense, M. D.
10.1101/2020.09.29.319418 — neuroscience — Posted on 2021-07-13
2392 The neurocomputational architecture of explore-exploit decision making
Hogeveen, J.; Mullins, T. S.; Romero, J.; Eversole, E.; Rogge-Obando, K.; Mayer, A. R.; Costa, V. D.
10.1101/2021.06.21.449128 — neuroscience — Posted on 2021-07-13
2397 Electronic "photoreceptors" enable prosthetic vision with acuity matching the natural resolution in rats
Wang, B.-Y.; Chen, Z. C.; Bhuckory, M.; Huang, T. W.; Shin, A.; Zuckerman, V.; Ho, E.; Rosenfeld, E.; Galambos, L.; Kamins, T.; Mathieson, K.; Palanker, D.
10.1101/2021.07.12.452093 — bioengineering — Posted on 2021-07-13
2398 Bioelectricity generation from live marine photosynthetic macroalgae
Shlosberg, Y.; Krupnik, N.; Toth, T. N.; Eichenbaum, B.; Meirovich, M.; Meiri, D.; Yehezkeli, O.; Schuster, G.; Israel, A.; Adir, N.
10.1101/2021.04.16.440133 — bioengineering — Posted on 2021-07-13
2399 Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 reveal a novel binding site for positive modulators
Botte, M.; Huber, S.; Bucher, D.; Klint, J. K.; Rodriguez, D.; Tagmose, L.; Chami, M.; Cheng, R. K. Y.; Hennig, M.; Abdul Rahman, W.
10.1101/2021.07.13.452180 — biochemistry — Posted on 2021-07-13
2400 Calorie Restriction Maintains Mitochondrial Function and Redox Balance Avoiding Lipidomic Reprogramming during Isoproterenol-Induced Cardiac Hypertrophy
David, C. E. B.; Lucas, A. M. B.; Cunha, P. L. O.; Viana, Y. I. P.; Yoshinaga, M. Y.; Miyamoto, S.; Chaves Filho, A. B.; Kowaltowski, A. J.; Facundo, H. T.
10.1101/2021.07.13.452233 — biochemistry — Posted on 2021-07-13
2403 Disentangling temporal associations in marine microbial networks
Deutschmann, I. M.; Krabberod, A. K.; Benites, L. F.; Latorre, F.; Delage, E.; Marrase, C.; Balague, V.; Gasol, J. M.; Massana, R.; Eveillard, D.; Chaffron, S.; Logares, R.
10.1101/2021.07.13.452187 — microbiology — Posted on 2021-07-13
2405 VirB4- and VirD4-like ATPases, components of a putative type 4C secretion system in Clostridioides difficile
Sorokina, J.; Sokolova, I.; Rybolovlev, I.; Shevlyagina, N.; Troitskiy, V.; Zhukhovitsky, V. G.; Belyi, Y.
10.1101/2021.07.12.452133 — microbiology — Posted on 2021-07-13
2407 A global dataset of seaweed net primary productivity
Pessarrodona, A.; Filbee-Dexter, K.; Krumhansl, K. A.; Moore, P. J.; Wernberg, T.
10.1101/2021.07.12.452112 — ecology — Posted on 2021-07-13
2408 Electrophysiological correlates of proactive and reactive inhibition in a modified visual Go/NoGo task
Kuty, J.; Damborska, A.; Linhartova, P.; Martin, L.; Jerabkova, B.; Rudisinova, D.; Bares, M.; Kasparek, T.
10.1101/2021.07.12.451610 — neuroscience — Posted on 2021-07-13
2409 2',3'-cAMP treatment mimics abiotic stress response
Chodasiewicz, M.; Kerber, O.; Gorka, M.; Moreno Beltran, J. C.; Sampathkumar, A.; Skirycz, A.
10.1101/2021.07.12.452129 — plant biology — Posted on 2021-07-13
2417 Predictions of biodiversity are improved by integrating trait-based competition with abiotic filtering
Chalmandrier, L.; Stouffer, D. B.; Purcell, A. S. T.; Lee, W. G.; Tanentzap, A. J.; Laughlin, D. C.
10.1101/2021.07.12.448750 — ecology — Posted on 2021-07-13
2421 Multiplex base editing to convert TAG into TAA codons in the human genome
Chen, Y.; Hysolli, E.; Chen, A.; Casper, S.; Liu, S.; Yang, K.; Liu, C.; Church, G.
10.1101/2021.07.13.452007 — synthetic biology — Posted on 2021-07-13
2424 Development Of The Inactivated QazCovid-In Vaccine: Protective Efficacy Of The Vaccine In Syrian Hamsters
Zhugunissov, K.; Zakarya, K.; Khairullin, B.; Orynbayev, M.; Abduraimov, Y.; Kassenov, M.; Sultankulova, K.; Kerimbayev, A.; Nurabayev, S.; Myrzhakhmetova, B.; Nakhanov, A.; Nurpeisova, A.; Chervyakova, O.; Assanzhanova, N.; Burashev, Y.; Mambetaliev, M.; Azanbekova, M.; Kopeyev, S.; Kozhabergenov, N.; Issabek, A.; Tuyskanova, M.; Kutumbetov, L.
10.1101/2021.07.13.452175 — immunology — Posted on 2021-07-13
2426 Immunogenicity and pre-clinical efficacy of an OMV-based SARS-CoV-2 vaccine
Grandi, A.; Tomasi, M.; Accordini, S.; Bertelli, C.; Vanzo, T.; Gagliardi, A.; Caproni, E.; Tamburini, S.; Fantappie, L.; Di Lascio, G.; Bisoffi, Z.; Piubelli, C.; Valenti, M. T.; Dalle Carbonare, L.; Zipeto, D.; Rava, M.; Fumagalli, V.; Di Lucia, P.; Marotta, D.; Sala, E.; Iannacone, M.; Cherepanov, P.; Bolognesi, M.; Pizzato, M.; Grandi, G.
10.1101/2021.07.12.452027 — immunology — Posted on 2021-07-13
2427 TNF-α levels in respiratory samples are associated with SARS-CoV-2 infection.
Pereson, M. J.; Badano, M. N.; Aloisi, N.; Chuit, R.; Braco, M. M.; Bare, P.
10.1101/2021.07.12.452071 — immunology — Posted on 2021-07-13
2428 In situ imaging of bacterial membrane projections and associated protein complexes using electron cryo-tomography
Kaplan, M.; Chreifi, G.; Metskas, L. A.; Liedtke, J.; Wood, C. R.; Oikonomou, C. M.; NICOLAS, W. J.; Subramanian, P.; Zacharoff, L. A.; Wang, Y.; Chang, Y.-W.; Beeby, M.; Dobro, M.; Mcbride, M. J.; Briegel, A.; Shaffer, C.; Jensen, G. J.
10.1101/2021.07.13.452161 — molecular biology — Posted on 2021-07-13
2429 Structural insight into Marburg virus nucleoprotein-RNA complex formation
Fujita-Fujiharu, Y.; Sugita, Y.; Takamatsu, Y.; Houri, K.; Igarashi, M.; Muramoto, Y.; Nakano, M.; Tsunoda, Y.; Becker, S.; Noda, T.
10.1101/2021.07.13.452116 — microbiology — Posted on 2021-07-13
2431 An atlas of the Norway spruce needle seasonal transcriptome
Bag, P.; Lihavainen, J.; Delhomme, N.; Riquelme, T.; Robinson, K. M.; Jansson, S.
10.1101/2021.07.12.452085 — plant biology — Posted on 2021-07-13
2432 Inulin nanostructures: The sweet-spot of carbohydrate self-assembly
Arnon, Z. A.; Grabarics, M.; Kreiser, T.; Raveh, A.; Pagel, K.; Gazit, E.
10.1101/2021.07.13.451276 — biophysics — Posted on 2021-07-13
2435 Development of photo-lenalidomide for cellular target identification
Lin, Z.; Amako, Y.; Kabir, F.; Flaxman, H. A.; Budnik, B.; Woo, C. M.
10.1101/2021.07.12.452075 — biochemistry — Posted on 2021-07-13
2436 Complete genomic and epigenetic maps of human centromeres
Altemose, N.; Logsdon, G.; Bzikadze, A. V.; Sidhwani, P.; Langley, S. A.; Caldas, G. V.; Hoyt, S. J.; Uralsky, L.; Ryabov, F. D.; Shew, C.; Sauria, M. E. G.; Borchers, M.; Gershman, A.; Mikheenko, A.; Shepelev, V. A.; Dvorkina, T.; Kunyavskaya, O.; Vollger, M. R.; Rhie, A.; McCartney, A. M.; Asri, M.; Lorig-Roach, R.; Shafin, K.; Aganezov, S.; Olson, D.; Gomes de Lima, L.; Potapova, T.; Hartley, G. A.; Haukness, M.; Kerpedjiev, P.; Gusev, F.; Tigyi, K.; Brooks, S. Y.; Young, A.; Nurk, S.; Koren, S.; Salama, S.; Paten, B.; Rogaev, E. I.; Streets, A. M.; Karpen, G. H.; Dernburg, A.; Sullivan, B.
10.1101/2021.07.12.452052 — genomics — Posted on 2021-07-13
2437 A complete reference genome improves analysis of human genetic variation
Aganezov, S.; Yan, S. M.; Soto, D. C.; Kirsche, M.; Zarate, S.; Avdeyev, P.; Taylor, D. J.; Shafin, K.; Shumate, A.; Xiao, C.; Wagner, J.; McDaniel, J.; Olson, N. D.; Sauria, M. E. G.; Vollger, M. R.; Rhie, A.; Meredith, M.; Martin, S.; Lee, J.; Koren, S.; Rosenfeld, J.; Paten, B.; Layer, R.; Chin, C.-S.; Sedlazeck, F. J.; Hansen, N. F.; Miller, D. E.; Phillippy, A. M.; Miga, K. H.; McCoy, R. C.; Dennis, M. Y.; Zook, J. M.; Schatz, M. C.
10.1101/2021.07.12.452063 — genomics — Posted on 2021-07-13
2438 Prolonged morphological expansion of spiny-rayed fishes following the end-Cretaceous
Ghezelayagh, A.; Harrington, R. C.; Burress, E. D.; Campbell, M. A.; Buckner, J. C.; Chakrabarty, P.; Glass, J. R.; McCraney, W. T.; Unmack, P. J.; Thacker, C. E.; Alfaro, M. E.; Friedman, S. T.; Ludt, W. D.; Cowman, P. F.; Friedman, M.; Price, S. A.; Dornburg, A.; Faircloth, B. C.; Wainwright, P. C.; Near, T. J.
10.1101/2021.07.12.452083 — evolutionary biology — Posted on 2021-07-13
2439 VCP protects neurons from proteopathic seeding
Zhu, J.; Pittman, S.; Dhavale, D.; French, R.; Patterson, J. N.; Kaleelurrrahuman, S.; Sun, Y.; Buchser, W.; Bieschke, J.; Kotzbauer, P.; Ayala, Y. M.; Davis, A. A.; Weihl, C. C.
10.1101/2021.07.12.452081 — neuroscience — Posted on 2021-07-13
2440 Single-nucleus sequencing reveals enriched expression of genetic risk factors sensitises Motor Neurons to degeneration in ALS
Limone, F.; Mordes, D.; Couto, A.; Pietilainen, O.; Joseph, B.; Burberry, A.; Ghosh, S. D.; Meyer, D.; Goldman, M.; Bortolin, L.; Cobos, I.; Therrien, M.; Stevens, B.; Kadiu, I.; McCarroll, S. A.; Eggan, K.
10.1101/2021.07.12.452054 — neuroscience — Posted on 2021-07-13
2441 Arousal impacts distributed hubs modulating the integration of brain functional connectivity
Lee, K.; Horien, C.; O'Connor, D.; Garand-Sheridan, B.; Tokoglu, F.; Scheinost, D.; Lake, E. M.; Constable, R. T.
10.1101/2021.07.12.452041 — neuroscience — Posted on 2021-07-13
2442 Electrocorticography based monitoring of anaesthetic depth in mice
Schmidt, D.; English, G.; Gent, T.; Yanik, M. F.; von der Behrens, W.
10.1101/2021.07.12.452032 — neuroscience — Posted on 2021-07-13
2445 Zinc2+ ion inhibits SARS-CoV-2 main protease and viral replication in vitro.
Panchariya, L.; Khan, W. A.; Kuila, S.; Sonkar, K.; Sahoo, S.; Ghoshal, A.; Kumar, A.; Verma, D. K.; Hasan, A.; Das, S.; Thakur, J. K.; Halder, R.; Sunil, S.; Arulandu, A.
10.1101/2021.06.15.448551 — biochemistry — Posted on 2021-07-13
2446 WDR82-binding long non-coding RNA lncEry controls mouse erythroid differentiation and maturation
Yang, S.; Sun, G.; Wu, P.; Cong, C.; Kuang, Y.; Zheng, Z.; He, Y.; Gu, Q.; Lu, T.; Zhu, C.; Wang, F.; Gou, F.; Yang, Z.; Zhao, X.; Yuan, S.; Yang, L.; Lu, S.; Li, Y.; Lv, X.; Dong, F.; Ma, Y.; Yu, J.; Ng, L. G.; Shi, L.; Liu, J.; Cheng, H.; Cheng, T.
10.1101/2021.07.13.452142 — cell biology — Posted on 2021-07-13
2449 ChronoRoot: High-throughput phenotyping by deep segmentation networks reveals novel temporal parameters of plant root system architecture
Gaggion, N.; Ariel, F.; Daric, V.; Lambert, E.; Legendre, S.; Roule, T.; Camoirano, A.; Milone, D. H.; Crespi, M.; Blein, T.; Ferrante, E.
10.1101/2020.10.27.350553 — plant biology — Posted on 2021-07-13
2450 Accessibility Over Transposable Elements Reveals Genetic Determinants of Stemness Properties in Normal and Leukemic Hematopoiesis
Nadorp, B.; Grillo, G.; Qamra, A.; Mitchell, A.; Arlidge, C.; Takayama, N.; Murison, A.; Tonekaboni, S. A. M.; Arruda, A.; Wang, J.; Minden, M.; Dick, J.; Lupien, M.
10.1101/2021.02.16.431334 — cancer biology — Posted on 2021-07-13
2451 A daily-updated database and tools for comprehensive SARS-CoV-2 mutation-annotated trees
McBroome, J.; Thornlow, B.; Hinrichs, A. S.; De Maio, N.; Goldman, N.; Haussler, D.; Corbett-Detig, R.; Turakhia, Y.
10.1101/2021.04.03.438321 — bioinformatics — Posted on 2021-07-13
2452 Positive selection and enhancer evolution shaped lifespan and body mass in great apes
Tejada-Martinez, D.; Avelar, R. A.; Lopes, I.; Zhang, B.; Novoa, G.; de Magalhaes, J. P.; Trizzino, M.
10.1101/2021.07.08.451631 — genomics — Posted on 2021-07-13
2455 Myosin-driven Nucleation of Actin Filaments Drives Stereocilia Development Critical for Hearing
Moreland, Z. G.; Jiang, F.; Aguilar, C.; Barzik, M.; Gong, R.; Shams, A.; Faaborg-Andersen, C.; Werth, J. C.; Harley, R.; Sutton, D. C.; Cole, S. M.; Parker, A.; Morse, S.; Wilson, E.; Takagi, Y.; Sellers, J. R.; Brown, S. D.; Friedman, T. B.; Alushin, G. M.; Bowl, M. R.; Bird, J. E.
10.1101/2021.07.09.451618 — cell biology — Posted on 2021-07-13
2456 UPF3A and UPF3B are redundant and modular activators of nonsense-mediated mRNA decay in human cells
Wallmeroth, D.; Boehm, V.; Lackmann, J.-W.; Altmueller, J.; Dieterich, C.; Gehring, N. H.
10.1101/2021.07.07.451444 — molecular biology — Posted on 2021-07-13
2457 Linker histone dH1K27 dimethylation marks Drosophila heterochromatin independently of H3K9 methylation
Bernues, J.; Izquierdo-Boulstridge, A.; Reina Garcia, O.; Castejon, L.; Fernandez-Castaner, E.; Leal, N.; Guerrero-Pepinosa, N.; Bonet-Costa, C.; Vujatovic, O.; Azorin, F.
10.1101/2021.06.22.449135 — molecular biology — Posted on 2021-07-13
2459 Highly diverse flavobacterial phages as mortality factor during North Sea spring blooms
Bartlau, N.; Wichels, A.; Krohne, G.; Adriaenssens, E. M.; Heins, A.; Fuchs, B. M.; Amann, R.; Moraru, C.
10.1101/2021.05.20.444936 — microbiology — Posted on 2021-07-13
2463 In vivo evidence that SORL1, encoding the endosomal recycling receptor SORLA, can function as a causal gene in Alzheimer's Disease
Andersen, O. M.; Boegh, N.; Landau, A. M.; Ploeen, G. G.; Jensen, A. M. G.; Monti, G.; Ulhoei, B. P.; Nyengaard, J. R.; Jacobsen, K. R.; Joergensen, M. M.; Holm, I. E.; Kristensen, M. L.; Hansen, E. S.; Teunissen, C. E.; Breidenbach, L.; Droescher, M.; Liu, Y.; Pedersen, H. S.; Callesen, H.; Luo, Y.; Bolund, L.; Brooks, D. J.; Laustsen, C.; Small, S. A.; Mikkelsen, L. F.; Soerensen, C. B.
10.1101/2021.07.13.452149 — neuroscience — Posted on 2021-07-13
2465 Dysregulated myogenesis and autophagy in genetically induced pulmonary emphysema
Balnis, J.; Drake, L. A.; Singer, D. V.; Vincent, C.; Korponay, T. C.; D'Armiento, J. M.; Lee, C. G.; Elias, J. A.; Singer, H. A.; Jaitovich, A.
10.1101/2021.07.08.450201 — physiology — Posted on 2021-07-13
2466 LISA: Learned Indexes for Sequence Analysis
Ho, D.; Kalikar, S.; Misra, S.; Ding, J.; Md, V.; Tatbul, N.; Li, H.; Kraska, T.
10.1101/2020.12.22.423964 — bioinformatics — Posted on 2021-07-13
2467 Clipper: p-value-free FDR control on high-throughput data from two conditions
Ge, X.; Chen, Y. E.; Song, D.; McDermott, M.; Woyshner, K.; Manousopoulou, A.; Wang, N.; Li, W.; Wang, L. D.; Li, J. J.
10.1101/2020.11.19.390773 — bioinformatics — Posted on 2021-07-13
2468 Linking rhizosphere processes across scales: Opinion
Schnepf, A.; Carminati, A.; Ahmed, M.; Ani, M.; Benard, P.; Bentz, J.; Bonkowski, M.; Brax, M.; Diehl, D.; Duddek, P.; Kroener, E.; Javaux, M.; Landl, M.; Lehndorff, E.; Lippold, E.; Lieu, A.; Mueller, C. W.; Oburger, E.; Otten, W.; Portell-Canal, X.; Phalempin, M.; Prechtel, A.; Schulz, R.; Vanderborght, J.; Vetterlein, D.
10.1101/2021.07.08.451655 — bioengineering — Posted on 2021-07-13
2471 Intraflagellar transport-A deficiency attenuates ADPKD in a renal tubular- and maturation-dependent manner
Wang, W.; Silva, L.; Wang, H.; Kavanaugh, M. A.; Pottorf, T.; Allard, B.; Jacobs, D.; Dong, R.; Cornelius, J.; Chaturvedi, A.; Pritchard, M.; Sharma, M.; Slawson, C.; Wallace, D.; Calvet, J.; Tran, P.
10.1101/2020.04.26.061796 — genetics — Posted on 2021-07-13
2472 Multivariate genome-wide association study on tissue-sensitive diffusion metrics identifies key molecular pathways for axonal growth, synaptogenesis, and astrocyte-mediated neuroinflammation
Fan, C. C.; Loughnan, R.; Pechva, D.; Chen, C.-H.; Hagler, D.; Thompson, W. K.; Parker, N.; van der Meer, D.; Frei, O.; Andreassen, O.; Dale, A. M.
10.1101/2021.06.24.449723 — genetics — Posted on 2021-07-13
2474 Mammalian UPF3A and UPF3B activate NMD independently of their EJC binding
Yi, Z.; Arvola, R. M.; Myers, S.; Dilsavor, C. N.; Abu Alhasan, R.; Carter, B. N.; Patton, R. D.; Bundschuh, R.; Singh, G.
10.1101/2021.07.02.450872 — molecular biology — Posted on 2021-07-13
2476 Assessing Overall Reproducibility for Large-scale High-throughput MRI-based Association Studies
Jiao, Z.; Lai, Y.; Kang, J.; Gong, W.; Ma, L.; Jia, T.; Xie, C.; Cheng, W.; Heinz, A.; Desrivieres, S.; Schumann, G.; Sun, F.; Feng, J.
10.1101/2020.08.18.253740 — neuroscience — Posted on 2021-07-13
2478 Human engineered skeletal muscle of hypaxial origin from pluripotent stem cells with advanced function and regenerative capacity
Shahriyari, M.; Islam, M.; Sakib, M.; Rika, A.; Krueger, D.; Kaurani, L.; Anandakumar, H.; Shomroni, O.; Schmidt, M.; Salinas, G.; Unger, A.; Linke, W.; Zschuentzsch, J.; Schmidt, J.; Fischer, A.; Zimmermann, W.; Tiburcy, M.
10.1101/2021.07.12.452030 — cell biology — Posted on 2021-07-12
2479 Lack of blocking activity in anti-CTLA-4 antibodies reduces toxicity, but not anti-tumor efficacy
Stone, E. L.; Carter, K. P.; Wagner, E. K.; Asensio, M. A.; Benzie, E.; Chiang, Y. Y.; Coles, G. L.; Edgar, C.; Gautam, B. K.; Gras, A.; Leong, J.; Leong, R.; Manickam, V. A.; Mizrahi, R. A.; Niedecken, A.; Saini, J.; Sandhu, S. K.; Simons, J. F.; Stadtmiller, K.; Tinsley, B.; Tracy, L.; Wayham, N. P.; Lim, Y. W.; Adler, A. A.; Johnson, D. S.
10.1101/2021.07.12.452090 — immunology — Posted on 2021-07-12
2480 Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer
Bell, E. S.; Shah, P.; Zuela - Sopilniak, N.; Kim, D.; McGregor, A. L.; Isermann, P.; Davidson, P.; Elacqua, J. J.; Lakins, J.; Vahdat, L.; Weaver, V.; Smolka, M. B.; Span, P.; Lammerding, J.
10.1101/2021.07.12.451842 — cancer biology — Posted on 2021-07-12
2481 Therapeutic base and prime editing of COL7A1 mutations in recessive dystrophic epidermolysis bullosa
Hong, S.-a.; Kim, S.-E.; Lee, A.-y.; Hwang, G.-h.; Kim, J. H.; Iwata, H.; Kim, S.-C.; Bae, S.; Lee, S. E.
10.1101/2021.07.12.452037 — bioengineering — Posted on 2021-07-12
2483 Newly Emergent Apelin Expressing Endothelial Stem-like Cells Orchestrate Lung Microvascular Repair
Godoy, R. S.; Cook, D. P.; Cober, N. D.; Deng, Y.; Wang, L.; Chakravarti, A.; Rowe, K.; Stewart, D. J.
10.1101/2021.07.12.452061 — cell biology — Posted on 2021-07-12
2487 Flight-tone mediated circadian control of audibility in mating swarms of Anopheles mosquitoes
Somers, J.; Georgiades, M.; Su, M. P.; Bagi, J.; Andres, M.; Mills, G.; Ntabaliba, W.; Moore, S. J.; Spaccapelo, R.; Albert, J. T.
10.1101/2021.07.12.452033 — neuroscience — Posted on 2021-07-12
2494 The spatial landscape of clonal somatic mutations in benign and malignant tissue
Erickson, A.; Berglund, E.; He, M.; Marklund, M.; Mirzazadeh, R.; Schultz, N.; Bergenstrahle, L.; Kvastad, L.; Andersson, A.; Bergenstrahle, J.; Larsson, L.; Shamikh, A.; Basmaci, E.; de Stahl, T. D.; Rajakumar, T.; Thrane, K.; Ji, A. L.; Khavari, P. A.; Tarish, F.; Tanoglidi, A.; Maaskola, J.; Colling, R.; Mirtti, T.; Hamdy, F. C.; Woodcock, D. J.; Helleday, T.; Mills, I. G.; Lamb, A. D.; Lundeberg, J.
10.1101/2021.07.12.452018 — genomics — Posted on 2021-07-12
2495 Coalescent-based species delimitation meets deep learning: Insights from a highly fragmented cactus system
Perez, M. F.; Bonatelli, I. A.; Romeiro-Brito, M.; Franco, F. F.; Taylor, N. P.; Zappi, D. C.; Moraes, E. M.
10.1101/2020.12.23.424219 — evolutionary biology — Posted on 2021-07-12
2497 C25-modified rifamycin derivatives with improved activity against Mycobacterium abscessus
Paulowski, L.; Beckham, K. S. H.; Johansen, M. D.; Berneking, L.; Van, N.; Degefu, Y.; Staack, S.; Vasquez Sotomayor, F.; Asar, L.; Rohde, H.; Aldridge, B. B.; Aepfelbacher, M.; Parret, A.; Wilmanns, M.; Kremer, L.; Combrink, K.; Maurer, F. P.
10.1101/2021.07.12.452042 — microbiology — Posted on 2021-07-12
2498 Macrophages stimulate epicardial VEGFaa expression to trigger cardiomyocyte proliferation in larval zebrafish heart regeneration
Bruton, F. A.; Kaveh, A.; Ross-Stewart, K.; Matrone, G.; Oremek, M. E.; Solomonidis, E. G.; Tucker, C. S.; Mullins, J. J.; Brittan, M.; Taylor, J. M.; Rossi, A. G.; Denvir, M. A.
10.1101/2021.06.15.448575 — immunology — Posted on 2021-07-12
2501 GWAS-associated variants, non-genetic factors, and transient transcriptome in Multiple Sclerosis etiopathogenesis: a colocalization analysis
Umeton, R.; Bellucci, G.; Bigi, R.; Romano, S.; Buscarinu, M. C.; Renie', R.; Rinaldi, V.; Pizzolato Umeton, R.; Morena, E.; Romano, C.; Mechelli, R.; Salvetti, M.; Ristori, G.
10.1101/2021.03.12.434773 — neuroscience — Posted on 2021-07-12
2504 Molecular insights into the μ-opioid receptorselective signaling
Sounier, R.; Granier, S.; Maurel, D.; Cong, X.; DEMENE, H.; Saint-Paul, J.; Peysson, F.; Vasiliauskaite-Brooks, I.; Hagelberger, J.; Golebiowski, J.
10.1101/2021.03.22.436421 — bioinformatics — Posted on 2021-07-12
2507 Variation in upstream open reading frames contributes to allelic diversity in protein abundance
Gage, J. L.; Mali, S.; McLoughlin, F.; Khaipho-Burch, M.; Monier, B.; Bailey-Serres, J.; Vierstra, R. D.; Buckler, E. S.
10.1101/2021.05.25.445499 — genomics — Posted on 2021-07-12
2511 Direct Antimicrobial Resistance Prediction from clinical MALDI-TOF mass spectra using Machine Learning
Weis, C.; Cuenod, A.; Rieck, B.; Llinares-Lopez, F.; Dubuis, O.; Graf, S.; Lang, C.; Oberle, M.; Brackmann, M.; Soegaard, K. K.; Osthoff, M.; Borgwardt, K.; Egli, A.
10.1101/2020.07.30.228411 — microbiology — Posted on 2021-07-12
2512 PKR-mediated Stress Response Enhances Dengue and Zika Virus Replication
Ricciardi-Jorge, T.; Lummertz da Rocha, E.; Gonzalez-Kozlova, E.; Rodrigues-Luiz, G. F.; Ferguson, B. J.; Irigoyen, N.; Mansur, D. S.
10.1101/2021.04.08.439069 — immunology — Posted on 2021-07-12
2513 How we pay attention in naturalistic visual search settings
Turoman, N.; Tivadar, R.; Retsa, C.; Murray, M. M.; Matusz, P. J.
10.1101/2020.07.30.229617 — neuroscience — Posted on 2021-07-12
2515 Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans
Maglioni, S.; Schiavi, A.; Melcher, M.; Brinkmann, V.; Luo, Z.; Raimundo, N.; Laromaine, A.; Meyer, J.; Distelmaier, F.; Ventura, N.
10.1101/2020.02.20.957225 — neuroscience — Posted on 2021-07-12
2517 Brain virtual histology with X-ray phase-contrast tomography Part I: whole-brain myelin mapping in white-matter injury models
Chourrout, M.; Rositi, H.; Ong, E.; Hubert, V.; Paccalet, A.; Foucault, L.; Autret, A.; Fayard, B.; Olivier, C.; Bolbos, R.; Peyrin, F.; Crola Da Silva, C.; Meyronet, D.; Raineteau, O.; Elleaume, H.; Brun, E.; Chauveau, F.; Wiart, M.
10.1101/2021.03.24.436852 — neuroscience — Posted on 2021-07-12
2519 Maternal RND3/RhoE deficiency impairs placental mitochondrial function in preeclampsia by modulating PPARγ-UCP2 cascade
Huang, L.; Ma, Y.; Chen, L.; Chang, J.; Zhong, M.; Wang, Z.; Sun, Y.; Chen, X.; Sun, F.; Xiao, L.; Chen, J.; Lai, Y.; Yan, C.; Yue, X.
10.1101/2020.06.22.164921 — pathology — Posted on 2021-07-12
2521 Differential fate of acellular vascular scaffolds in vivo involves macrophages and T-cell subsets
Banerjee, D.; Nayakawde, N. B.; Antony, D.; Deshmukh, M.; Ghosh, S.; Sihlbom, C.; Berger, E.; Ul Haq, U.; Olausson, M.
10.1101/2020.11.21.392654 — bioengineering — Posted on 2021-07-12
2522 Strong attraction of male mosquitoes (Aedes aegypti) to humans
Amos, B. A.; Hoffmann, A. A.; Staunton, K. M.; Lau, M.-J.; Burkot, T. R.; Ross, P. A.
10.1101/2021.05.24.445527 — animal behavior and cognition — Posted on 2021-07-12
2526 Drug-free nasal spray as a barrier against SARS-CoV-2 infection: safety and efficacy in human nasal airway epithelia
Fais, F.; Juskeviciene, R.; Francardo, V.; Mateos, S.; Constant, S.; Borelli, M.; Hohenfeld, I. P.; Meyer, T.
10.1101/2021.07.12.452021 — pharmacology and toxicology — Posted on 2021-07-12
2528 High throughput and affordable genome-wide methylation profiling of circulating cell-free DNA by Methylated DNA sequencing (MeD-seq) of LpnPI digested fragments
Deger, T.; Boers, R. G.; de Weerd, V.; Angus, L.; van der Put, M. M.; Boers, J. B.; Azmani, Z.; van IJcken, W.; Grunhagen, D. J.; van Dessel, L. F.; Lolkema, M. P.; Verhoef, C.; Sleijfer, S.; Martens, J. W.; Gribnau, J.; Wilting, S. M.
10.1101/2021.07.12.452012 — genomics — Posted on 2021-07-12
2529 Zic1 advances epaxial myotome morphogenesis to cover the neural tube via Wnt11r
Heilig, A. K.; Nakamura, R.; Shimada, A.; Hashimoto, Y.; Nakamura, Y.; Wittbrodt, J.; Takeda, H.; Kawanishi, T.
10.1101/2021.07.12.452069 — developmental biology — Posted on 2021-07-12
2532 In situ solid-liquid extraction enhances recovery of taxadiene from engineered S. cerevisiae cell factories
Santoyo-Garcia, J.; Walls, L.; Nowrouzi, B.; Ochoa-Villareal, M.; Loake, G.; Dimartino, S.; Rios-Solis, L.
10.1101/2021.07.12.452013 — bioengineering — Posted on 2021-07-12
2534 From telomere to telomere: the transcriptional and epigenetic state of human repeat elements
Hoyt, S. J.; Storer, J. M.; Hartley, G. A.; Grady, P. G. S.; Gershman, A.; de Lima, L. G.; Limouse, C.; Halabian, R.; Wojenski, L.; Rodriguez, M.; Altemose, N.; Core, L.; Gerton, J. L.; Makalowski, W.; Olson, D.; Rosen, J.; Smit, A. F. A.; Straight, A. F.; Vollger, M. R.; Wheeler, T.; Schatz, M.; Eichler, E.; Phillippy, A. M.; Timp, W.; Miga, K. H.; O'Neill, R. J.
10.1101/2021.07.12.451456 — genomics — Posted on 2021-07-12
2536 Novel insights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis.
Uehara, Y.; Nikolaidis, N. M.; Pitstick, L. B.; Wu, H.; Yu, J. J.; Zhang, E.; Hasegawa, Y.; Tanaka, Y.; Noel, J. G.; Gardner, J. C.; Kopras, E. J.; Haffey, W. D.; Greis, K. D.; Guo, J.; Woods, J. C.; Wikenheiser-Brokamp, K. A.; Zhao, S.; Xu, Y.; Kyle, J. E.; Ansong, C.; Teitelbaum, S. L.; Inoue, Y.; Altinisik, G.; McCormack, F. X.
10.1101/2021.07.11.451970 — molecular biology — Posted on 2021-07-12
2538 Pooled screening of CAR T cells identifies non-native signaling domains for next- generation immunotherapies
Goodman, D. B.; Azimi, C. S.; Kearns, K.; Garakani, K.; Garcia, J.; Patel, N.; Hwang, B.; Lee, D.; Park, E.; Ye, C. J.; Marson, A.; Bluestone, J.; Roybal, K.
10.1101/2021.07.11.451980 — immunology — Posted on 2021-07-12
2540 Custom-made design of metabolite composition in N. benthamiana leaves using CRISPR activators.
Selma, S.; Sanmartin, N.; Espinosa-Ruiz, A.; Gianoglio, S.; Lopez-Gresa, M. P.; Vazquez-Vilar, M.; Flors, V.; Granell, A.; Orzaez, D.
10.1101/2021.07.12.452005 — synthetic biology — Posted on 2021-07-12
2544 Cooperative escape in ants and robots
Srinivasa Gopalakrishnan, G. P.; Mandal, S.; Giardina, F.; Kennedy, J.; Murthy, V. N.; Mahadevan, L.
10.1101/2021.07.12.451633 — animal behavior and cognition — Posted on 2021-07-12
2545 Genomic and transcriptomic analyses of the subterranean termite Reticulitermes speratus: gene duplication facilitates social evolution
Shigenobu, S.; Hayashi, Y.; Watanabe, D.; Tokuda, G.; Hojo, M. Y.; Toga, K.; Saiki, R.; Yaguchi, H.; Masuoka, Y.; Suzuki, R.; Suzuki, S.; Kimura, M.; Matsunami, M.; Sugime, Y.; Oguchi, K.; Niimi, T.; Gotoh, H.; Hojo, M. K.; Miyazaki, S.; Toyoda, A.; Miura, T.; Maekawa, K.
10.1101/2021.07.11.451559 — genomics — Posted on 2021-07-12
2548 Genome mosaicism in field strains of Mycoplasma bovis as footprints of in-host horizontal chromosomal transfer
Garcia-Galan, A.; Baranowski, E.; Hygonenq, M.-C.; Walch, M.; Croville, G.; Citti, C.; De la Fe, C.; Nouvel, L.-X.
10.1101/2021.07.12.452010 — evolutionary biology — Posted on 2021-07-12
2553 PPARdelta signaling activation improves metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes.
Wickramasinghe, N. M.; Sachs, D.; Shewale, B.; Gonzalez, D. M.; Dhanan-Krishnan, P.; Torre, D.; LaMarca, E.; Raimo, S.; Dariolli, R.; Serasinghe, M.; Mayourian, J.; Sebra, R.; Beaumont, K. G.; Iyengar, R.; French, D. L.; Hansen, A.; Eschenhagen, T.; Chipuk, J. E.; Sobie, E. A.; Jacobs, A.; Akbarian, S.; Ischiropoulos, H.; Ma'ayan, A.; Houten, S.; Costa, K.; Dubois, N. C.
10.1101/2021.07.12.451352 — cell biology — Posted on 2021-07-12
2558 Disentangling marine microbial networks across space
Deutschmann, I. M.; Delage, E.; Giner, C. R.; Sebastian, M.; Poulain, J.; Aristegui, J.; Duarte, C. M.; Acinas, S. G.; Massana, R.; Gasol, J. M.; Eveillard, D.; Chaffron, S.; Logares, R.
10.1101/2021.07.12.451729 — microbiology — Posted on 2021-07-12
2560 Nitrous Oxide Enhances Focused Ultrasound Mediated Delivery of Viral Gene Therapy
Shah, B. R.; Bailey, R. M.; Youssef, I.; Holmes, S. K.; Marckx, A.; Estill-Terpac, S. J.; Diamond, M.; Chopra, R.
10.1101/2021.07.11.451978 — neuroscience — Posted on 2021-07-12
2565 A corollary discharge mediates saccade related inhibition of single units in mnemonic structures of the human brain
Katz, C. N.; Schjetnan, A. G. P.; Patel, K. V.; Barkley, V.; Hoffman, K. L.; Kalia, S. K.; Duncan, K.; Valiante, T. A.
10.1101/2021.07.12.450085 — neuroscience — Posted on 2021-07-12
2567 Sex Identification in Cattle, based on Amelogenin Gene
Ahmad, A.; Israr, M.; Rahat, M. A.; Wahab, A.; Uddin, S.; Rasool, A.; Akbar, F.; Shah, M.
10.1101/2021.07.11.451984 — zoology — Posted on 2021-07-12
2568 Variation in root system architecture among the founder parents of two 8-way MAGIC wheat populations for selection in breeding
Pariyar, S.; Nagel, K. A.; Lentz, J.; Galinski, A.; Wilhelm, J.; Putz, A.; Adels, S.; Heinz, K.; Frohberg, C.; Watt, M.
10.1101/2021.07.12.451891 — plant biology — Posted on 2021-07-12
2572 Critical Assessment of Metagenome Interpretation - the second round of challenges
Meyer, F.; Fritz, A.; Deng, Z.-L.; Koslicki, D.; Gurevich, A.; Robertson, G.; Zhu, J.; Jia, H.; Kola, A.; Limasset, A.; Kolmogorov, M.; Egan, R.; Rosen, G. L.; Cristian, A.; Zhao, Z.; Gray, M. A.; Nissen, J.; Zeller, G.; Paoli, L.; Ruscheweyh, H.-J.; Milanese, A.; Sunagawa, S.; Alser, M.; Shi, L.; Chen, B.; Wang, Z.; Wang, Z.; Huang, P.; You, R.; Sun, F.; Zhu, S.; Bertrand, D.; Tong, C.; Li, C.; Nagarajan, N.; Renard, B.; Malcher-Miranda, F.; Piro, V. C.; Chikhi, R.; Vicedomini, R.; Wang, Z.; Thomas, A.; Tremblay, J.; Dabrowski, P. W.; Nurk, S.; Jorgensen, T. S.; Willassen, N. P.; Klemetsen, T
10.1101/2021.07.12.451567 — bioinformatics — Posted on 2021-07-12
2574 An integrated analysis tool reveals intrinsic biases in gene set enrichment
Thakur, N.; Pujol, N.; van Helden, J.; Waterston, R. H.; Hillier, L. W.; Tichit, L.; Ewbank, J. J.
10.1101/2021.07.12.452009 — bioinformatics — Posted on 2021-07-12
2577 Chemoproteomic profiling reveals cellular targets of nitro-fatty acids
Fang, M.; Huang, K. H.; Tu, W.-J.; Chen, Y.-T.; Pan, P.-Y.; Hsiao, W.-C.; Ke, Y.-Y.; Tsou, L. K.; Zhang, M. M.
10.1101/2021.07.12.451990 — biochemistry — Posted on 2021-07-12
2578 Mapping the nuclear microenvironment of genes at agenome-wide scale
Yildirim, A.; Hua, N.; Boninsegna, L.; Polles, G.; Gong, K.; Hao, S.; Li, W.; Zhou, X. J.; Alber, F.
10.1101/2021.07.11.451976 — genomics — Posted on 2021-07-12
2579 Native MOWChIP-seq: Genome-wide profiles of key protein bindings reveal functional differences among various brain regions
Liu, Z.; Naler, L. B.; Zhu, Y.; Deng, C.; Zhang, Q.; Zhu, B.; Zhou, Z.; Sarma, M.; Murray, A.; Xie, H.; Lu, C.
10.1101/2021.07.11.451963 — genomics — Posted on 2021-07-12
2582 Lentiviral vector optimization enhances the expression and cytotoxicity of chimeric antigen receptors
Guo, C.; Chen, H.; Yu, J.; Lu, H.; Guo, X.; Li, X.; Wang, T.; Zhi, L.; Niu, Z.; Zhu, W.
10.1101/2021.07.11.451925 — cell biology — Posted on 2021-07-12
2583 Artemisinin acts by inhibiting Plasmodium falciparum Ddi1, a retropepsin, resulting into the accumulation of ubiquitinated proteins
Onchieku, N. M.; Kumari, S.; Pandey, R.; Sharma, V.; Kumar, M.; Deshmukh, A.; Kaur, I.; Mohmmed, A.; Gupta, D.; Kiboi, D.; Gaur, N.; Malhotra, P.
10.1101/2021.07.12.452004 — cell biology — Posted on 2021-07-12
2586 Pathogenic and transcriptomic differences of emerging SARS-CoV-2 variants in the Syrian golden hamster model
O'Donnell, K. L.; Pinski, A. N.; Clancy, C. S.; Gourdine, T.; Shifflett, K.; Fletcher, P.; Messaoudi, I.; Marzi, A.
10.1101/2021.07.11.451964 — microbiology — Posted on 2021-07-12
2589 Wall-associated Receptor Kinase and The Expression Profiles in Wheat Responding to Fungal Stress
Zhang, H.; Li, H.; Zhang, X.; Yan, W.; Deng, P.; Zhang, Y.; Peng, S.; Wang, Y.; Wang, C.; Ji, W.
10.1101/2021.07.11.451968 — plant biology — Posted on 2021-07-12
2590 SARS-CoV-2 Spike Protein Mutations and Escape from Antibodies: a Computational Model of Epitope Loss in Variants of Concern
Triveri, A.; Serapian, S. A.; Marchetti, F.; Doria, F.; Pavoni, S.; Cinquini, F.; Moroni, E.; Rasola, A.; Frigerio, F.; Colombo, G.
10.1101/2021.07.12.452002 — biophysics — Posted on 2021-07-12
2592 High rate of mutational events in SARS-CoV-2 genomes across Brazilian geographical regions, February 2020 to June 2021
Souza, U. J. B. d.; Santos, R. N. d.; Campos, F. S.; Lourenco, K. L.; Fonseca, F. G. d.; Spilki, F. R.; Corona-omica.BR MCTI Network,
10.1101/2021.07.10.451922 — genomics — Posted on 2021-07-12
2595 Niclosamide reverses SARS-CoV-2 control of lipophagy
Garrett, T.; Coatsworth, H.; Mahmud, I.; Hamerly, T.; Stephenson, C. J.; Yazd, H.; Ayers, J. B.; Miller, M.; Lednicky, J. A.; Dinglasan, R. R.
10.1101/2021.07.11.451951 — microbiology — Posted on 2021-07-12
2596 Altered costimulatory signals and hypoxia support chromatin landscapes limiting the functional potential of exhausted T cells in cancer
Ford, B. R.; Rittenhouse, N. L.; Scharping, N. E.; Vignali, P. D. A.; Frisch, A. T.; Peralta, R.; Delgoffe, G. M.; Poholek, A. C.
10.1101/2021.07.11.451947 — immunology — Posted on 2021-07-12
2598 Chemically Induced Senescence in Human Stem Cell-Derived Neurons Promotes Phenotypic Presentation of Neurodegeneration
Fathi, A.; Mathivanan, S.; Kong, L.; Petersen, A. J.; Harder, C. R. K.; Block, J.; Miller, J. M.; Bhattacharyya, A.; Wang, D.; Zhang, S.-C.
10.1101/2021.07.11.451956 — neuroscience — Posted on 2021-07-12
2601 Circuit motifs and graph properties of connectome development in C. elegans
Matelsky, J. K.; Norman-Tenazas, R.; Davenport, F.; Reilly, E. P.; Gray-Roncal, W. R.
10.1101/2021.07.11.451911 — bioinformatics — Posted on 2021-07-12
2602 Ecology and transmission of a dengue virus serotype 4 identified in wild Aedes aegypti in Florida
Ayers, J. B.; Xie, X.; Coatsworth, H.; Stephenson, C. J.; Waits, C. M.; Shi, P. Y.; Dinglasan, R. R.
10.1101/2021.07.11.451177 — microbiology — Posted on 2021-07-12
2604 Dynamics of glioma-associated microglia and macrophages reveals their divergent roles in the immune response of brain
Qian, J.; Wang, C.; Wang, B.; Li, C.; Fu, K.; Wang, Y.; Gao, Y.; Niu, C.; Zhao, C.; Liu, J.; Wang, L.; Liu, R.; Luo, F.; Lu, M.; Liu, Y.; Chu, Y.
10.1101/2021.07.11.451874 — immunology — Posted on 2021-07-12
2609 Evolution of a confluent gut epithelium under cyclic stretching
Geremie, L.; Ilker, E.; Bernheim-Dennery, M.; Cavaniol, C.; Viovy, J.-L.; Matic Vignjevic, D.; Joanny, J.-F.; Descroix, S.
10.1101/2021.07.10.451888 — biophysics — Posted on 2021-07-12
2610 Power Calculator for Detecting Allelic Imbalance Using Hierarchical Bayesian Model
Sherbina, K.; Leon-Novelo, L. G.; Nuzhdin, S. V.; McIntyre, L. M.; Marroni, F.
10.1101/2021.07.10.451873 — bioinformatics — Posted on 2021-07-12
2615 Gluconobacter oxydans Knockout Collection Finds Improved Rare Earth Element Extraction
Schmitz, A. M.; Pian, B.; Medin, S.; Reid, M. C.; Wu, M.; Gazel, E.; Barstow, B.
10.1101/2021.07.11.451920 — genomics — Posted on 2021-07-12
2618 Independent adoptions of a set of proteins found in the matrix of the mineralized shell-like eggcase of Argonaut octopuses
Setiamarga, D. H. E.; Hirota, K.; Ikai, R.; Imoto, S.; Sato, N.; Ono, H.; Isowa, Y.; Yonemitsu, H.; Sasaki, T.; Yoshida, M.-a.
10.1101/2021.07.10.451900 — evolutionary biology — Posted on 2021-07-12
2620 Evolution with private resources reverses some changes from long-term evolution with public resources
van Raay, K.; Stolyar, S.; Sevigny, J.; Draghi, J.; Lenski, R. E.; Marx, C. J.; Kerr, B.; Zaman, L.
10.1101/2021.07.11.451942 — evolutionary biology — Posted on 2021-07-12
2623 A recombinant protein containing influenza viral conserved epitopes and superantigen induces broad-spectrum protection
Li, Y.; Xu, M.; Li, Y.; Gu, W.; Halimu, G.; Li, Y.; Zhang, Z.; Zhou, L.; Liao, H.; Yao, S.; Zhang, H.; Zhang, C.
10.1101/2021.07.08.451596 — epidemiology — Posted on 2021-07-10
2625 A multiple hypotheses framework to study movement ecology and diet in a migratory songbird
Contina, A.; Pierce, A. K.; Yanco, S. W.; Bridge, E. S.; Kelly, J. F.; Wunder, M. B.
10.1101/2021.07.10.451926 — ecology — Posted on 2021-07-12
2631 Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography
Vagenknecht, P.; Ono, M.; Luzgin, A.; Ji, B.; Higuchi, M.; Noain, D.; Maschio, C.; Sobek, J.; Chen, Z.; Konietzko, U.; Gerez, J. A.; Riek, R.; Nitsch, R. M.; Razansky, D.; Klohs, J.; Dean-Ben, X. L.; Ni, R.
10.1101/2021.07.10.451626 — neuroscience — Posted on 2021-07-12
2634 The co-evolution of the genome and epigenome in colorectal cancer
Heide, T.; Househam, J.; Spiteri, I.; Lynn, C.; Cresswell, G. D.; Mossner, M.; Kimberley, C.; Fernandez-Mateos, J.; Chen, B.; Zapata, L.; James, C.; Barozzi, I.; Chkhaidze, K.; Nichol, D.; Berner, A.; Schmidt, M.; Lakatos, E.; Baker, A.-M.; Costa, H.; Mitchinson, M.; Jansen, M.; Caravagna, G.; Ramazzotti, D.; Shibata, D.; Bridgewater, J.; Rodriguez-Justo, M.; Magnani, L.; Graham, T. A.; Sottoriva, A.
10.1101/2021.07.12.451121 — cancer biology — Posted on 2021-07-12
2641 Serotonin GPCR-based biosensing modalities in yeast
Lengger, B.; Hoch-Schneider, E. E.; Noerskov, C.; Jakociunas, T.; Jensen, E. D.; Jensen, M. K.
10.1101/2021.07.12.452006 — bioengineering — Posted on 2021-07-12
2642 Molecular architecture of the human tRNA ligase complex
Kroupova, A.; Ackle, F.; Boneberg, F. M.; Chui, A.; Weitzer, S.; Faini, M.; Leitner, A.; Aebersold, R.; Martinez, J.; Jinek, M.
10.1101/2021.07.11.451954 — biochemistry — Posted on 2021-07-12
2643 The habenula clock influences prediction of danger
Basnakova, A.; Cheng, R.-K.; Chia, J. S. M.; D'Agostino, G. A.; Suryadi, ; Tan, G. J. H.; Langley, S. R.; Jesuthasan, S. J.
10.1101/2020.04.29.067108 — neuroscience — Posted on 2021-07-12
2644 Brain-engrafted macrophages provide protection against therapeutic irradiation and secondary concussive injury
Feng, X.; Frias, E.; Paladini, M.-S.; Chen, D.; Boosalis, Z.; Becker, M.; Gupta, S.; Liu, S.; Gupta, N.; Rosi, S.
10.1101/794354 — neuroscience — Posted on 2021-07-12
2648 Early reduction in PD-L1 expression predicts faster treatment response in human cutaneous leishmaniasis
Dey, N. S.; Senarathna, S.; Somaratne, V.; Madarasinghe, N.; Seneviratne, B.; Forrester, S. S.; Montes De Oca, M.; Reis, L. C.; Moulik, S.; Walrad, P.; Chatterjee, M.; Goto, H.; Wickremasinghe, R.; Lagos, D.; Kaye, P. M.; Ranasinghe, S.
10.1101/2020.02.21.959528 — immunology — Posted on 2021-07-12
2649 Motor dysfunction in Drosophila melanogaster as a biomarker for developmental neurotoxicity
Cabrita, A.; Medeiros, A. M.; Pereira, T.; Rodrigues, A. S.; Kranendonk, M.; Mendes, C. S.
10.1101/2021.07.09.451676 — neuroscience — Posted on 2021-07-12
2650 Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia
Gong, R.; Jiang, F.; Moreland, Z. G.; Reynolds, M. J.; Espinosa de los Reyes, S.; Gurel, P. S.; Shams, A.; Bowl, M. R.; Bird, J. E.; Alushin, G. M.
10.1101/2021.07.09.451843 — biophysics — Posted on 2021-07-12
2654 High-throughput variant detection using a color-mixing strategy
Xie, N. G.; Zhang, K.; Song, P.; Li, R.; Luo, J.; Zhang, D. Y.
10.1101/2021.06.30.450651 — genetics — Posted on 2021-07-12
2661 Towards rainy Arctic winters: experimental icing impacts tundra plant productivity and reproduction
Le Moullec, M.; Hendel, A.-L.; Petit Bon, M.; Jonsdottir, I. S.; Varpe, O.; van der Wal, R.; Beumer, L.; Layton-Matthews, K.; Isaksen, K.; Hansen, B. B.
10.1101/2021.06.10.447955 — plant biology — Posted on 2021-07-12
2663 The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth
Sandovici, I.; Georgopoulou, A.; Perez-Garcia, V.; Hufnagel, A. S.; Lopez-Tello, J.; Lam, B. Y. H.; Schiefer, S. N.; Gaudreau, C.; Santos, F.; Hoelle, K.; Yeo, G. S. H.; Burling, K.; Reiterer, M.; Fowden, A. L.; Burton, G. J.; Sferruzzi-Perri, A. N.; Branco, C. M.; Constancia, M.
10.1101/520536 — developmental biology — Posted on 2021-07-12
2664 Bacteria are everywhere, even in your COI marker gene data!
Zafeiropoulos, H.; Gargan, L.; Hintikka, S.; Pavloudi, C.; Carlsson, J.
10.1101/2021.07.10.451903 — bioinformatics — Posted on 2021-07-11
2665 Distributed and multifaceted effects of threat and safety
Morrow, K.; Murty, D. V. P. S.; Kim, J.; Song, S.; Hu, K.; Pessoa, L.
10.1101/2021.07.11.451944 — neuroscience — Posted on 2021-07-11
2666 Coupled protein synthesis and ribosome-guided piRNA processing on mRNAs
Sun, Y. H.; Wang, R. H.; Du, K.; Zheng, J.; Xie, L. H.; Pereira, A. A.; Zhang, C.; Ricci, E. P.; Li, X. Z.
10.1101/2021.07.10.451906 — molecular biology — Posted on 2021-07-11
2669 Molecular spikes: a gold standard for single-cell RNA counting
Ziegenhain, C.; Hendriks, G.-J.; Hagemann-Jensen, M.; Sandberg, R.
10.1101/2021.07.10.451877 — genomics — Posted on 2021-07-11
2671 CARPOOL: A library-based platform to rapidly identify next generation chimeric antigen receptors
Kyung, T.; Gordon, K. S.; Perez, C. R.; Holec, P. V.; Ramos, A.; Zhang, A. Q.; Liu, Y.; Koch, C.; Starchenko, A.; Joughin, B.; Lauffenburger, D. A.; Irvine, D. J.; Hemann, M. T.; Birnbaum, M. E.
10.1101/2021.07.09.450900 — immunology — Posted on 2021-07-11
2674 Adolescent Brain Cognitive Development (ABCD) Community MRI Collection and Utilities
Feczko, E.; Conan, G.; Marek, S.; Tervo-Clemens, B.; Cordova, M.; Doyle, O.; Earl, E.; Perrone, A.; Sturgeon, D.; Klein, R.; Harman, G.; Kilamovich, D.; Hermosillo, R.; Miranda-Dominguez, O.; Adebimpe, A.; Bertolero, M.; Cieslak, M.; Covitz, S.; Hendrickson, T.; Juliano, A. C.; Snider, K.; Moore, L. A.; Uriartel, J.; Graham, A. M.; Calabro, F.; Rosenberg, M. D.; Rapuano, K. M.; Casey, B.; Watts, R.; Hagler, D.; Thompson, W. K.; Nichols, T. E.; Hoffman, E.; Luna, B.; Garavan, H.; Satterthwaite, T. D.; Feldstein Ewing, S.; Nagel, B.; Dosenbach, N. U.; Fair, D. A.
10.1101/2021.07.09.451638 — neuroscience — Posted on 2021-07-11
2678 Structure of ATP synthase from ESKAPE pathogen Acinetobacter baumannii
Demmer, J. K.; Phillips, B. P.; Uhrig, O. L.; Filloux, A.; Allsopp, L. P.; Bublitz, M.; Meier, T.
10.1101/2021.07.10.451757 — biochemistry — Posted on 2021-07-11
2684 Pili Expression in Geobacter sulfurreducens Lacking the Putative Gene for the PilB Pilus Assembly Motor
Ueki, T.; Walker, D. J.; Nevin, K. P.; Ward, J. E.; Woodard, T. L.; Nonnenmann, S. S.; Lovley, D. R.
10.1101/2021.07.10.451916 — microbiology — Posted on 2021-07-11
2686 The organization of the gravity-sensing system in zebrafish
Liu, Z.; Hildebrand, D. G. C.; Morgan, J. L.; Slimmon, N.; Bagnall, M. W.
10.1101/2021.07.09.451839 — neuroscience — Posted on 2021-07-11
2689 A patient-driven clinicogenomic partnership through the Metastatic Prostate Cancer Project
Crowdis, J.; Balch, S.; Sterlin, L.; Thomas, B. S.; Camp, S. Y.; Dunphy, M.; Anastasio, E.; Shah, S.; Damon, A. L.; Ramos, R.; Sosa, D. M.; Small, I. K.; Tomson, B.; Nguyen, C. M.; McGillicuddy, M.; Chastain, P. S.; He, M. X.; Cheung, A. T. M.; Wankowicz, S.; Tewari, A. K.; Kim, D.; AlDubayan, S. H.; Dowdye, A.; Zola, B.; Nowak, J.; Manarite, J.; Gunn, I. H.; Olson, B.; Lander, E. S.; Painter, C. A.; Wagle, N.; Van Allen, E. M.
10.1101/2021.07.09.451849 — cancer biology — Posted on 2021-07-11
2690 The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes
Costello, S. M.; Shoemaker, S. R.; Hobbs, H. T.; Nguyen, A. W.; Hsieh, C.-L.; Maynard, J. A.; McLellan, J. S.; Pak, J. E.; Marqusee, S.
10.1101/2021.07.11.451855 — biophysics — Posted on 2021-07-11
2693 Unconventional tonicity-regulated nuclear trafficking of NFAT5 mediated by KPNB1, XPOT and RUVBL2
Cheung, C. Y.; Huang, T.-T.; Chow, N.; Zhang, S.; Zhao, Y.; Wong, C. C.; Boassa, D.; Phan, S.; Ellisman, M. H.; Yates, J. R.; Xu, S.; Yu, Z.; Zhang, Y.; Zhang, R.; Ng, L. L.; Ko, B. C. B.
10.1101/2021.07.11.451941 — cell biology — Posted on 2021-07-11
2694 A Massively Parallel Trafficking Assay Accurately Predicts Loss of Channel Function in KCNH2 Variants
Ng, C. A.; Ullah, R.; Farr, J.; Hill, A. P.; Kozek, K. A.; Vanags, L. R.; Mitchell, D. W.; Kroncke, B. M.; Vandenberg, J. I.
10.1101/2021.07.10.451881 — biophysics — Posted on 2021-07-11
2698 Functional analysis of Mmd2 and related PAQR genes during sex determination in mice
Zhao, L.; Thomson, E.; Ng, E. T.; Longmuss, E.; Svingen, T.; Bagheri-Fam, S.; Quinn, A.; Harley, V. R.; Harrison, L. C.; Pelosi, E.; Koopman, P.
10.1101/2021.07.10.451886 — developmental biology — Posted on 2021-07-11
2699 Splicing Factor SRSF1 Deficiency in the Liver Triggers NASH-like Pathology via R-Loop Induced DNA Damage and Cell Death
Arif, W.; Mathur, B.; Saikali, M. F.; Chembazhi, U. V.; Blue, S. M.; Yee, B. A.; Van Nostrand, E. L.; Bangru, S.; Hao, Q.; Yeo, G. W.; Prasanth, K. V.; Anakk, S.; Cummins, C. L.; Kalsotra, A.
10.1101/2021.07.10.451875 — cell biology — Posted on 2021-07-11
2700 Condensate-mediated reactivation of mumps virus infection under stress
Zhang, X.; Sridharan, S.; Zagoriy, I.; Eugster Oegema, C.; Ching, C.; Pflaesterer, T.; Fung, H. K. H.; Poser, I.; Mueller, C. W.; Hyman, A. A.; Savitski, M. M.; Mahamid, J.
10.1101/2021.07.10.451879 — cell biology — Posted on 2021-07-11
2701 TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells
Osnato, A.; Brown, S.; Krueger, C.; Andrews, S.; Collier, A. J.; Nakanoh, S.; Quiroga Londono, M.; Wesley, B. T.; Muraro, D.; Brumm, S.; Niakan, K.; Vallier, L.; Ortmann, D.; Rugg-Gunn, P. J.
10.1101/2021.07.10.451887 — cell biology — Posted on 2021-07-11
2705 Optimization of the TeraTox assay for preclinical teratogenicity assessment
Jaklin, M.; Zhang, J. D.; Schaefer, N.; Clemann, N.; Barrow, P.; Kueng, E.; Sach-Peltason, L.; McGinnis, C.; Leist, M.; Kustermann, S.
10.1101/2021.07.06.451364 — pharmacology and toxicology — Posted on 2021-07-11
2707 Zygotic contractility awakening during mouse preimplantation development
Özgüc, O.; de Plater, L.; Kapoor, V.; Tortorelli, A.-F.; Maitre, J.-L.
10.1101/2021.07.09.451745 — developmental biology — Posted on 2021-07-11
2708 A novel imaging ligand as a biomarker for mutant huntingtin-lowering in Huntington's disease
Bertoglio, D.; Bard, J.; Hessmann, M.; Liu, L.; Gaertner, A.; De Lombaerde, S.; Huscher, B.; Zajicek, F.; Miranda, A.; Peters, F.; Herrmann, F.; Schaertl, S.; Vasilkovska, T.; Brown, C. J.; Johnson, P. D.; Prime, M. E.; Mills, M. R.; Van der Linden, A.; Mrzljak, L.; Khetarpal, V.; Wang, Y.; Marchionini, D. M.; Skinbjerg, M.; Verhaeghe, J.; Dominguez, C.; Staelens, S.; Munoz-Sanjuan, I.
10.1101/2021.07.09.451725 — neuroscience — Posted on 2021-07-11
2711 One billion synthetic 3D-antibody-antigen complexes enable unconstrained machine-learning formalized investigation of antibody specificity prediction
Robert, P. A.; Akbar, R.; Frank, R.; Pavlovic, M.; Widrich, M.; Snapkov, I.; Chernigovskaya, M.; Scheffer, L.; Slabodkin, A.; Mehta, B. B.; Vu, M. H.; Prosz, A.; Abram, K.; Olar, A.; Miho, E.; Haug, D. T. T.; Lund-Johansen, F.; Hochreiter, S.; Hobaek Haff, I.; Klambauer, G.; Sandve, G. K.; Greiff, V.
10.1101/2021.07.06.451258 — immunology — Posted on 2021-07-11
2712 GWAS-associated variants, non-genetic factors, and transient transcriptome in Multiple Sclerosis etiopathogenesis: a colocalization analysis
Umeton, R.; Bellucci, G.; Bigi, R.; Romano, S.; Buscarinu, M. C.; Renie', R.; Rinaldi, V.; Pizzolato Umeton, R.; Morena, E.; Romano, C.; Mechelli, R.; Salvetti, M.; Ristori, G.
10.1101/2021.03.12.434773 — neuroscience — Posted on 2021-07-10
2721 Selective whole genome amplification as a tool to enrich specimens with low Treponema pallidum genomic DNA copies for whole genome sequencing
Thurlow, C. M.; Joseph, S. J.; Ganova-Raeva, L. M.; Katz, S.; Pereira, L.; Chen, C.-Y.; Debra, A.; Vilfort, K.; Workowski, K.; Cohen, S.; Reno, H.; Sun, Y.; Burroughs, M.; Sheth, M.; Chi, K.-H.; Danavall, D.; Philip, S.; Cao, W.; Kersh, E.; Pillay, A.
10.1101/2021.07.09.451864 — genomics — Posted on 2021-07-10
2722 Mutations in Drosophila tRNA processing factors cause phenotypes similar to Pontocerebellar Hypoplasia
Schmidt, C. A.; Min, L. Y.; McVay, M. H.; Giusto, J. D.; Brown, J. C.; Salzler, H. R.; Matera, A. G.
10.1101/2021.07.09.451847 — genetics — Posted on 2021-07-10
2725 Borgs are giant extrachromosomal elements with the potential to augment methane oxidation
Al-Shayeb, B.; Schoelmerich, M. C.; West-Roberts, J.; Valentin-Alvarado, L. E.; Sachdeva, R.; Mullen, S.; Crits-Christoph, A.; Wilkins, M. J.; Williams, K. H.; Doudna, J. A.; Banfield, J. F.
10.1101/2021.07.10.451761 — microbiology — Posted on 2021-07-10
2726 A mouse-adapted SARS-CoV-2 strain replicating in standard laboratory mice.
Montagutelli, X.; Prot, M.; Jouvion, G.; Levillayer, L.; Conquet, L.; Reyes-Gomez, E.; Donati, F.; Albert, M.; van der Werf, S.; Jaubert, J.; Simon-Loriere, E.
10.1101/2021.07.10.451880 — microbiology — Posted on 2021-07-10
2728 Nucleolar stress controls mutant Huntingtin toxicity and monitors Huntington disease progression
Soenmez, A.; Mustafa, R.; Ryll, S. T.; Tuorto, F.; Wacheul, L.; Ponti, D.; Litke, C.; Hering, T.; Kojer, K.; Koch, J.; Pitzer, C.; Kirsch, J.; Neueder, A.; Kreiner, G.; Lafontaine, D. L.; Orth, M.; Liss, B.; Parlato, R.
10.1101/2021.07.09.451766 — neuroscience — Posted on 2021-07-10
2729 Neural excitation/inhibition imbalance and the treatment of severe depression
ten Doesschate, F.; Bruin, W.; Zeidman, P.; Abbott, C.; Argyelan, M.; Dols, A.; Emsell, L.; van Eijndhoven, P. F. P.; van Exel, E.; Mulders, P. C. R.; Narr, K. L.; Tendolkar, I.; Rhebergen, D.; Sienaert, P.; Vandenbulcke, M.; Verdijk, J.; van Verseveld, M.; Bartsch, H.; Oltedal, L.; van Waarde, J. A.; van Wingen, G. A.
10.1101/2021.07.09.451784 — neuroscience — Posted on 2021-07-10
2730 One-week escitalopram intake shifts excitation-inhibition balance in the healthy female brain
Zsido, R. G.; Molloy, E. N.; Cesnaite, E.; Zheleva, G.; Beinhölzl, N.; Scharrer, U.; Piecha, F. A.; Regenthal, R.; Villringer, A.; Nikulin, V. V.; Sacher, J.
10.1101/2021.07.09.451806 — neuroscience — Posted on 2021-07-10
2731 Small RNA profiling in Mycobacterium insights into stress adapt ability
Chen, Y.; Zhai, W.; Zhang, K.; Zhu, T.; Su, L.; Bermudez, L. E.; Chen, H.; Guo, A.
10.1101/2021.07.09.451870 — zoology — Posted on 2021-07-10
2734 Photoprotective qH in Arabidopsis occurs in the light-harvesting complex II trimer
Bru, P.; Steen, C. J.; Park, S.; Amstutz, C. L.; Sylak-Glassman, E. J.; Leuenberger, M.; Lam, L.; Longoni, F.; Fleming, G. R.; Niyogi, K. K.; Malnoë, A.
10.1101/2021.07.09.450705 — plant biology — Posted on 2021-07-10
2736 HepT1-derived murine models of high-risk hepatoblastoma display vascular invasion, metastasis, and circulating tumor cells
Woodfield, S. E.; Mistretta, B. J.; Patel, R. H.; Ibarra, A. M.; Fisher, K. E.; Sarabia, S. F.; Gandhi, I.; Reuther, J.; Starosolski, Z.; Badachhape, A.; Shah, A. P.; Larson, S. R.; Srivastava, R. K.; Shi, Y.; Whitlock, R. S.; Holloway, K.; Roy, A.; Ghaghada, K. B.; Lopez-Terrada, D.; Gunaratne, P. H.; Vasudevan, S. A.
10.1101/2021.07.09.451809 — cancer biology — Posted on 2021-07-10
2738 Single-cell transcriptomics for the 99.9% of species without reference genomes
Botvinnik, O. B.; Vemuri, P.; Pierce Ward, N. T.; Logan, P. A.; Nafees, S.; Karanam, L.; Travaglini, K. J.; Ezran, C. S.; Ren, L.; Wang, J.; Huang, Y.; Wang, J.; Brown, C. T.
10.1101/2021.07.09.450799 — bioinformatics — Posted on 2021-07-10
2747 De novo whole-genome assembly of Chrysanthemum makinoi, a key wild ancestor to hexaploid Chrysanthemum
van Lieshout, N.; van Kaauwen, M.; Kodde, L.; Arens, P.; Smulders, M. J. M.; Visser, R. G. F.; Finkers, R.
10.1101/2021.07.09.451814 — genomics — Posted on 2021-07-10
2749 On the Etiology of Aesthetic Chills: a Behavioral Genetic Study
Bignardi, G.; Chamberlain, R.; Kevenaar, S. T.; Tamimy, Z.; Boomsma, D. I.
10.1101/2021.07.08.451681 — genetics — Posted on 2021-07-10
2750 Antisense oligonucleotides targeting UBE3A-ATS restore expression of UBE3A by relieving transcriptional interference
Germain, N. D.; Gorka, D.; Drennan, R.; Whipple, A.; Jafar-nejad, P.; Core, L.; Levine, E. S.; Rigo, F.; Chamberlain, S. J.
10.1101/2021.07.09.451826 — genetics — Posted on 2021-07-10
2752 A gene coevolution network provides insight into eukaryotic cellular and genomic structure and function
Steenwyk, J. L.; Phillips, M. A.; Yang, F.; Date, S. S.; Graham, T.; berman, j.; Hittinger, C. T.; Rokas, A.
10.1101/2021.07.09.451830 — evolutionary biology — Posted on 2021-07-10
2755 A tail of plumage colouration: disentangling geographic, seasonal, and dietary effects on plumage colour in a migratory songbird
Mahoney, S. M.; Reudink, M. W.; Contina, A.; Roberts, K. A.; Schabert, V. T.; Gunther, E. G.; Covino, K. M.
10.1101/2021.07.09.451669 — ecology — Posted on 2021-07-10
2761 Novel low-avidity glypican-3 specific CARTs resist exhaustion and mediate durable antitumor effects against hepatocellular carcinoma
Caraballo-Galva, L.; Hussein, M.; Jiang, X.; Zhang, H.; Mao, R.; Brody, P.; Chi, X.; Peng, Y.; He, A.; Kehinge-Ige, M.; Sadek, R.; Shi, H.; Qiu, X.; He, Y.
10.1101/2021.07.09.451642 — immunology — Posted on 2021-07-10
2762 The PD-1 checkpoint receptor maintains tolerance of self-reactive CD8 T cell in skin
Damo, M.; Cui, C.; William, I.; Hornick, N. I.; Kwok, D.; Clulo, K.; Damsky, W. E.; Leventhal, J. S.; Joshi, N. S.
10.1101/2021.07.09.451765 — immunology — Posted on 2021-07-10
2763 Motor dysfunction in Drosophila melanogaster as a biomarker for developmental neurotoxicity
Cabrita, A.; Medeiros, A. A.; Pereira, T.; Rodrigues, A. S.; Kranendonk, M.; Mendes, C. S.
10.1101/2021.07.09.451676 — neuroscience — Posted on 2021-07-10
2765 α-Synuclein polymorphism determines oligodendroglial dysfunction
Frieg, B.; Geraets, J. A.; Strohaeker, T.; Dienemann, C.; Mavroeidi, P.; Jung, B. C.; Kim, W.; Lee, S.-J.; Xilouri, M.; Zweckstetter, M.; Schroeder, G. F.
10.1101/2021.07.09.451731 — neuroscience — Posted on 2021-07-10
2766 Atp13a5 Marker Reveals Pericytes of The Central Nervous System in Mice
Guo, X.; Ge, T.; Xia, S.; Wu, H.; Colt, M.; Xie, X.; Zhang, B.; Zeng, J.; Chen, J.-F.; Zhu, D.; Montagne, A.; Gao, F.; Zhao, Z.
10.1101/2021.07.09.451694 — neuroscience — Posted on 2021-07-10
2773 Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia
Gong, R.; Jiang, F.; Moreland, Z. G.; Reynolds, M. J.; Espinosa de los Reyes, S.; Gurel, P. S.; Shams, A.; Bowl, M. R.; Bird, J. E.; Alushin, G. M.
10.1101/2021.07.09.451843 — biophysics — Posted on 2021-07-10
2774 Cross-linkers at growing microtubule ends generate forces that drive actin transport
Alkemade, C.; Wierenga, H.; Volkov, V. A.; Preciado-Lopez, M.; Akhmanova, A.; ten Wolde, P. R.; Dogterom, M.; Koenderink, G. H.
10.1101/2021.07.09.451744 — biophysics — Posted on 2021-07-10
2776 Linking rhizosphere processes across scales: Opinion
Schnepf, A.; Carminati, A.; Ahmed, M.; Ani, M.; Benard, P.; Bentz, J.; Bonkowski, M.; Brax, M.; Diehl, D.; Duddek, P.; Kroener, E.; Javaux, M.; Landl, M.; Lehndorff, E.; Lippold, E.; Lieu, A.; Mueller, C. W.; Oburger, E.; Otten, W.; Phalempin, M.; Prechtel, A.; Schulz, R.; Vanderborght, J.; Vetterlein, D.
10.1101/2021.07.08.451655 — bioengineering — Posted on 2021-07-10
2783 Metabolic state of human blastocysts measured by fluorescence lifetime imaging microscopy
Venturas, M.; Shah, J. S.; Yang, X.; Sanchez, T. H.; Conway, W.; Sakkas, D.; Needleman, D. J.
10.1101/2021.07.09.451821 — cell biology — Posted on 2021-07-10
2787 Myosin-driven Nucleation of Actin Filaments Drives Stereocilia Development Critical for Hearing
Moreland, Z. G.; Jiang, F.; Aguilar, C.; Barzik, M.; Gong, R.; Shams, A.; Faaborg-Andersen, C.; Werth, J. C.; Harley, R.; Sutton, D. C.; Cole, S. M.; Parker, A.; Morse, S.; Wilson, E.; Takagi, Y.; Sellers, J. R.; Brown, S. D.; Friedman, T. B.; Alushin, G. M.; Bowl, M. R.; Bird, J. E.
10.1101/2021.07.09.451618 — cell biology — Posted on 2021-07-10
2790 Temporal regulation of Pten is essential for retina regeneration in zebrafish
Gupta, S.; Sharma, P.; Choudhary, M.; Premraj, S.; Kaur, S.; Kumar, V.; Ramachandran, R.
10.1101/2021.07.09.451767 — cell biology — Posted on 2021-07-10
2792 De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis
Laval, T.; Pedro-Cos, L.; Malaga, W.; Guenin-Mace, L.; Pawlik, A.; Mayau, V.; Yahia-Cherbal, H.; Frigui, W.; Bertrand-Michel, J.; Guilhot, C.; Demangel, C.
10.1101/2021.07.08.451715 — immunology — Posted on 2021-07-10
2793 Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathology
Reifschneider, A.; Robinson, S.; van Lengerich, B.; Gnoerich, J.; Logan, T.; Heindl, S.; Vogt, M.; Weidinger, E.; Riedl, L.; Wind, K.; Zatcepin, A.; Haberl, S.; Nuscher, B.; Kleinberger, G.; Klimmt, J.; Goetzl, J.; Liesz, A.; Buerger, K.; Brendel, M.; Levin, J.; Diehl-Schmid, J.; Suh, J.; Di Paolo, G.; Lewcock, J.; Monroe, K.; Paquet, D.; Capell, A.; Haass, C.
10.1101/2021.07.08.451574 — neuroscience — Posted on 2021-07-10
2794 Double nerve transfer to a single target muscle: experimental model in the upper extremity
Luft, M.; Klepetko, J.; Muceli, S.; Ibanez, J.; Tereshenko, V.; Festin, C.; Laengle, G.; Politikou, O.; Maierhofer, U.; Farina, D.; Aszmann, O. C.; Bergmeister, K. D.
10.1101/2021.07.09.451759 — neuroscience — Posted on 2021-07-10
2795 Multi-environment QTL analysis delineates a major locus associated with homoeologous exchanges for water-use efficiency and seed yield in allopolyploid Brassica napus
Raman, H.; Raman, R.; Pirathiban, R.; McVittie, B.; Sharma, N.; Liu, S.; Qiu, Y.; Zhu, A.; Killian, A.; Cullis, B.; Farquhar, G.; Williams, H. S.; White, R.; Tabah, D.; Easton, A.; Zhang, Y.
10.1101/2021.07.08.451711 — plant biology — Posted on 2021-07-10
2796 Thioredoxin reductase controls the capacity of peroxiredoxins to limit mitochondrial H2O2 release
Hoehne, M. N.; Jacobs, L. J.; Lapacz, K. J.; Murschall, L. M.; Marker, T.; Morgan, B.; Fricker, M.; Belousov, V.; Riemer, J.
10.1101/2021.07.08.451718 — biochemistry — Posted on 2021-07-10
2802 Structural modeling of the hERG potassium channel and associated drug interactions
Maly, J.; Emigh, A. M.; DeMarco, K. R.; Furutani, K.; Sack, J. T.; Clancy, C. E.; Vorobyov, I.; Yarov-Yarovoy, V.
10.1101/2021.07.08.451699 — biophysics — Posted on 2021-07-10
2804 Differential fate of acellular vascular scaffolds in vivo involves macrophages and T-cell subsets
Banerjee, D.; Nayakawde, N. B.; Antony, D.; Deshmukh, M.; Ghosh, S.; Sihlbom, C.; Berger, E.; Ul Haq, U.; Olausson, M.
10.1101/2020.11.21.392654 — bioengineering — Posted on 2021-07-10
2805 Desiccation-induced fibrous condensation of CAHS protein from an anhydrobiotic tardigrade
Yagi-Utsumi, M.; Aoki, K.; Watanabe, H.; Song, C.; Nishimura, S.; Satoh, T.; Yanaka, S.; Ganser, C.; Tanaka, S.; Schnapka, V.; Goh, E. W.; Furutani, Y.; Murata, K.; Uchihashi, T.; Arakawa, K.; Kato, K.
10.1101/2021.06.22.449423 — biochemistry — Posted on 2021-07-10
2810 Serotonergic neural network related to behavioral inhibition system
Kojima, K.; Hirano, S.; Kimura, Y.; Seki, C.; Ikoma, Y.; Takahata, K.; Ito, T.; Yokokawa, K.; Hashimoto, H.; Kawamura, K.; Zhang, M.-R.; Ito, H.; Higuchi, M.; Kuwabara, S.; Suhara, T.; Yamada, M.
10.1101/2021.07.09.451787 — neuroscience — Posted on 2021-07-10
2812 Subspace alignment as a mechanism for binding
Fine, J. M.; Yoo, S. B. M.; Ebitz, B.; Hayden, B.
10.1101/2021.07.07.451472 — neuroscience — Posted on 2021-07-10
2813 Disrupted microglial iron homeostasis in progressive multiple sclerosis
Proto, J. D.; Zhang, M.; Ryan, S.; Yao, X.; Huang, Y.; Chang, Y.-C.; Dufault, M.; Christie, E.; Chomyk, A.; Saleh, J.; Blazier, A.; Sancho, J.; Hammond, T.; Trapp, B.; Ofengeim, D.
10.1101/2021.05.09.443127 — neuroscience — Posted on 2021-07-10
2815 Single-cell profiling of the human primary motor cortex in ALS and FTLD
Pineda, S. S.; Lee, H.; Fitzwalter, B. E.; Mohammadi, S.; Pregent, L. J.; Gardashli, M. E.; Mantero, J.; Engelberg-Cook, E.; DeJesus-Hernandez, M.; van Blitterswijk, M.; Pottier, C.; Rademakers, R.; Oskarsson, B.; Shah, J. S.; Petersen, R. C.; Graff-Radford, N. R.; Boeve, B. F.; Knopman, D. S.; Josephs, K. A.; DeTure, M.; Murray, M. E.; Dickson, D. W.; Heiman, M.; Belzil, V. V.; Kellis, M.
10.1101/2021.07.07.451374 — neuroscience — Posted on 2021-07-10
2816 End-to-end computational approach to the design of RNA biosensors for miRNA biomarkers of cervical cancer
Baabu, P. R. S.; Srinivasan, S.; Nagarajan, S.; Muthamilselvan, S.; Suresh, R. R.; Selvi, T.; Palaniappan, A.
10.1101/2021.07.09.451282 — synthetic biology — Posted on 2021-07-10
2818 Dysregulated myogenesis and autophagy in genetically induced pulmonary emphysema
Balnis, J.; Drake, L. A.; Singer, D. V.; Vincent, C.; Korponay, T. C.; D'Armiento, J. M.; Lee, C. G.; Elias, J. A.; Singer, H. A.; Jaitovich, A.
10.1101/2021.07.08.450201 — physiology — Posted on 2021-07-10
2822 The 3D enhancer network of the developing T cell genome is controlled by SATB1
Zelenka, T.; Klonizakis, A.; Tsoukatou, D.; Franzenburg, S.; Tzerpos, P.; Papamatheakis, D. A.; Tzonevrakis, I. R.; Nikolaou, C.; Plewczynski, D.; Spilianakis, C.
10.1101/2021.07.09.451769 — molecular biology — Posted on 2021-07-09
2825 Co-cultivation of the anaerobic fungus Caecomyces churrovis with Methanobacterium bryantii enhances transcription of carbohydrate binding modules
Brown, J. L.; Swift, C. L.; Mondo, S.; Seppala, S.; Salamov, A.; Singan, V.; Henrissat, B.; Henske, J. K.; Lee, S.; He, G.; Yan, M.; Barry, K.; Grigoriev, I. V.; O'Malley, M. A.
10.1101/2021.07.09.451685 — microbiology — Posted on 2021-07-09
2826 A combination of metagenomic and cultivation approaches reveals hypermutator phenotypes within Vibrio cholerae infected patients
Levade, I.; Khan, A. I.; Chowdhury, F.; Calderwood, S. B.; Ryan, E. T.; Harris, J. B.; LaRocque, R. C.; Bhuiyan, T. R.; Qadri, F.; Weil, A. A.; Shapiro, B. J.
10.1101/2020.10.11.333682 — microbiology — Posted on 2021-07-09
2829 Sensory coding and causal impact of mouse cortex in a visual decision
Zatka-Haas, P.; Steinmetz, N. A.; Carandini, M.; Harris, K. D.
10.1101/501627 — neuroscience — Posted on 2021-07-09
2834 Resilience in a Natural Model of Metabolic Dysfunction Through Changes in Longevity and Ageing-Related Metabolites
Medley, J. K.; Persons, J.; Biswas, T.; Olsen, L.; Peuss, R.; Krishnan, J.; Xiong, S.; Rohner, N.
10.1101/2020.10.27.358077 — systems biology — Posted on 2021-07-09
2835 Cellular-level phenotyping of tumor-immune microenvironment (TiME) in patients in vivo reveals distinct inflammation and endothelial anergy signatures
Sahu, A.; Tembo, T.; Kose, K.; Santella, A.; Alfonso, A.; Li, M.; Cordova, M.; Gill, M.; Fox, C.; Gonzalez, S.; Wang, A. W.; Kurtansky, N. R.; Chandrani, P.; Kumar, P.; Yin, S.; Jilani, H.; Mehta, P.; Navarrete-Dechent, C.; Peterson, G.; King, K.; Dusza, S.; Yang, N.; Liu, S.; Phillip, W.; Rossi, A.; Halpern, A.; Deng, L.; Pulitzer, M.; Marghoob, A.; Chen, C.-S. J.; Rajadhyaksha, M.
10.1101/2021.06.10.447835 — cancer biology — Posted on 2021-07-09
2836 SUFI: An automated approach to spectral unmixing of fluorescent multiplex images captured in mouse and postmortem human brain tissues
Sadashivaiah, V.; Tippani, M.; Page, S. C.; Kwon, S. H.; Bach, S. V.; Bharadwaj, R. A.; Hyde, T. M.; Kleinman, J. E.; Jaffe, A. E.; Maynard, K. R.
10.1101/2021.01.28.428639 — bioinformatics — Posted on 2021-07-09
2837 Non-Newtonian Patient-specific Simulations of Left Atrial Hemodynamics
Gonzalo, A.; Garcia-Villalba, M.; Rossini, L.; Duran, E.; Vigneault, D.; Martinez-Legazpi, P.; Flores, O.; Bermejo, J.; McVeigh, E.; Kahn, A.; del Alamo, J. C.
10.1101/2021.06.24.449801 — bioengineering — Posted on 2021-07-09
2839 Global patterns of subgenome evolution in organelle-targeted genes of sixallotetraploid angiosperms
Sharbrough, J.; Conover, J.; Fernandes Gyorfy, M.; Grover, C.; Miller, E. R.; Wendel, J. F.; Sloan, D. B.
10.1101/2021.07.09.451712 — evolutionary biology — Posted on 2021-07-09
2841 In silico proof of principle of machine learning-based antibody design at unconstrained scale
Akbar, R.; Robert, P. A.; Weber, C. R.; Widrich, M.; Frank, R.; Pavlovic, M.; Scheffer, L.; Chernigovskaya, M.; Snapkov, I.; Slabodkin, A.; Mehta, B. B.; Miho, E.; Lund-Johansen, F.; Andersen, J. T.; Hochreiter, S.; Haff, I. H.; Klambauer, G.; Sandve, G. K.; Greiff, V.
10.1101/2021.07.08.451480 — immunology — Posted on 2021-07-09
2844 Organization of cortical and thalamic input to inhibitory neurons in mouse motor cortex
Okoro, S. U.; Goz, R. U.; Njeri, B. W.; Harish, M.; Ruff, C. F.; Ross, S. E.; Gerfen, C. R.; Hooks, B. M.
10.1101/2021.07.08.451716 — neuroscience — Posted on 2021-07-09
2847 Curcumin micronization by supercritical fluid: in vitro and in vivo biological relevance
Sachett, A.; Gallas-Lopes, M.; Benvenutti, R.; Marcon, M.; Aguiar, G. P. S.; Oliveira, J. V.; Herrmann, A. P.; Siebel, A. M.; Piato, A.
10.1101/2021.07.08.451641 — neuroscience — Posted on 2021-07-09
2849 Obtaining Spatially Resolved Tumor Purity Maps Using Deep Multiple Instance Learning In A Pan-cancer Study
Oner, M. U.; Chen, J.; Revkov, E.; James, A.; Heng, S. Y.; Kaya, A. N.; Alvarez, J. J. S.; Takano, A.; Cheng, X. M.; Lim, T. K. H.; Tan, D. S. W.; Zhai, W.; Jacobsen Skanderup, A.; Sung, W.-K.; Lee, H. K.
10.1101/2021.07.08.451443 — cancer biology — Posted on 2021-07-09
2850 CALIPER: A software for blood-free parametric Patlak mapping using PET/MRI input function.
Dassanayake, P.; Cui, L.; Finger, E.; Kewin, M.; Hadaway, J.; Soddu, A.; Jakoby, B.; Zuehlsdorff, S.; St Lawrence, K. S.; Moran, G.; Anazodo, U. C.
10.1101/2021.07.08.451713 — bioinformatics — Posted on 2021-07-09
2851 Photoredox-catalyzed decarboxylative C-terminal differentiation for bulk and single molecule proteomics
Zhang, L.; Floyd, B. M.; Chilamari, M.; Mapes, J.; Swaminathan, J.; Bloom, S.; Marcotte, E. M.; Anslyn, E. V.
10.1101/2021.07.08.451692 — biochemistry — Posted on 2021-07-09
2852 An Empirical Bayes Approach to Estimating Dynamic Models of Co-regulated Gene Expression
Venkatraman, S.; Basu, S.; Clark, A. G.; Delbare, S. Y. N.; Lee, M. H.; Wells, M. T.
10.1101/2021.07.08.451684 — genomics — Posted on 2021-07-09
2856 A photoactivable natural product with broad antiviral activity against enveloped viruses including highly pathogenic coronaviruses
Meunier, T.; Desmarets, L.; Bordage, S.; Bamba, M.; Hervouet, K.; Rouille, Y.; Francois, N.; Decossas, M.; Tra Bi, F. H.; Lambert, O.; Dubuisson, J.; Belouzard, S.; Sahpaz, S.; Seron, K.
10.1101/2021.07.09.451770 — microbiology — Posted on 2021-07-09
2857 Therapeutic efficacy of CT-P59 against P.1 variant of SARS-CoV-2
Lee, S.-Y.; Ryu, D.-K.; Kang, b.; Noh, H.; Kim, J.; Seo, J.-M.; Kim, C.; Baalen, C. v.; Tijsma, A. S.; Chung, H.-Y.; Lee, M.-H.; Oh, S.-S.; Choi, J.-a.; Song, M.; Kwon, K.-S.
10.1101/2021.07.08.451696 — microbiology — Posted on 2021-07-09
2858 Reduced neutralization of SARS-CoV-2 B.1.617 variant by inactivated and RBD-subunit vaccine
Hu, J.; Wei, X.-y.; Xiang, J.; Peng, P.; Xu, F.-l.; Wu, K.; Luo, F.-y.; Jin, A.-s.; Fang, L.; Liu, B.-z.; Wang, K.; Tang, N.; Huang, A.
10.1101/2021.07.09.451732 — microbiology — Posted on 2021-07-09
2859 Impact of temperature on the affinity of SARS-CoV-2 Spike for ACE2
Prevost, J.; Richard, J.; Gasser, R.; Ding, S.; Fage, C.; Anand, S. P.; Adam, D.; Gupta Vergara, N.; Tauzin, A.; Benlarbi, M.; Gong, S. Y.; Goyette, G.; Prive, A.; Moreira, S.; Charest, H.; Roger, M.; Mothes, W.; Pazgier, M.; Brochiero, E.; Boivin, G.; Abrams, C. F.; Schon, A.; Finzi, A.
10.1101/2021.07.09.451812 — microbiology — Posted on 2021-07-09
2860 Persistent autism-relevant phenotype produced by in utero and lactational exposure of female mice to the commercial PBDE mixture, DE-71
Kozlova, E. V.; Valdez, M. C.; Denys, M. E.; Bishay, A. E.; Krum, J. M.; Rabbani, K. M.; Carrillo, V.; Gonzalez, G. M.; Lampel, G.; Tran, J. D.; Vazquez, B. M.; Anchondo, L. M.; Uddin, S. A.; Huffman, N. M.; Monarrez, E.; Olomi, D. S.; Chinthirla, B. D.; Hartman, R. E.; Kodavanti, P. S. R.; Chompre, G.; Phillips, A. L.; Stapleton, H. M.; Henkelmann, B.; Schramm, K.-W.; Curras-Collazo, M. C.
10.1101/2021.07.08.451690 — neuroscience — Posted on 2021-07-09
2861 Dysregulated myogenesis and autophagy in genetically induced pulmonary emphysema
Balnis, J.; Drake, L. A.; Singer, D. V.; Vincent, C.; Korponay, T. C.; D'Armiento, J. M.; Lee, C. G.; Elias, J. A.; Singer, H. A.; Jaitovich, A.
10.1101/2021.07.08.450201 — physiology — Posted on 2021-07-09
2862 The mitochondrial Na+/Ca2+ exchanger, NCLX, mediates PDE2 dependent neuronal survival and learning
Rozenfeld, M.; Savic Azoulay, I.; Ben Kasus Nissim, T.; Stavsky, A.; Hershfinkel, M.; Kofman, O.; Sekler, I.
10.1101/2021.07.08.451717 — physiology — Posted on 2021-07-09
2870 Cell-type specific transcriptional adaptations of nucleus accumbens interneurons to amphetamine
Gallegos, D. A.; Minto, M.; Liu, F.; Hazlett, M. F.; Yousefzadeh, S. A.; Bartelt, L. C.; West, A. E.
10.1101/2021.07.08.451674 — neuroscience — Posted on 2021-07-09
2871 Time-resolved structure-function coupling in brain networks
Liu, Z.-Q.; Vazquez-Rodriguez, B.; Spreng, R. N.; Bernhardt, B.; Betzel, R. F.; Misic, B.
10.1101/2021.07.08.451672 — neuroscience — Posted on 2021-07-09
2873 The Ubiquitous Vigilance Signal in fMRI Time Series Data
Gonzalez-Castillo, J.; Fernandez, I.; Handwerker, D. A.; Bandettini, P. A.
10.1101/2021.07.08.451677 — neuroscience — Posted on 2021-07-09
2877 Standardizing workflows in imaging transcriptomics with the abagen toolbox
Markello, R.; Arnatkeviciute, A.; Poline, J.-B.; Fulcher, B. D.; Fornito, A.; Misic, B.
10.1101/2021.07.08.451635 — neuroscience — Posted on 2021-07-09
2882 RESEPT: tissue architecture inference and visualization from spatially resolved transcriptomics
Chang, Y.; He, F.; Wang, J.; Chen, S.; Li, J.; Liu, J.; Yu, Y.; Su, L.; Ma, A.; Allen, C.; Lin, Y.; Sun, S.; Liu, B.; Otero, J.; Chung, D.; Fu, H.; Li, Z.; Xu, D.; Ma, Q.
10.1101/2021.07.08.451210 — bioinformatics — Posted on 2021-07-09
2883 Glycocalyx engineering with heparan sulfate mimetics attenuates Wnt activity during adipogenesis to promote glucose uptake and metabolism.
Trieger, G.; Pessentheiner, A.; Purcell, S.; Green, C. R.; DeForest, N.; Willert, K.; Majithia, A.; Metallo, C.; Godula, K.; Gordts, P.
10.1101/2021.07.08.451710 — cell biology — Posted on 2021-07-09
2884 Centriole distal-end proteins CP110 and Cep97 influence cartwheel growth at the proximal-end of centrioles
Aydogan, M. G.; Hankins, L. E.; Steinacker, T. L.; Mofatteh, M.; Saurya, S.; Wainman, A.; Wong, S. S.; Lu, X.; Zhou, F. Y.; Raff, J. W.
10.1101/2021.07.08.451650 — cell biology — Posted on 2021-07-09
2885 Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) Up to 15 Months Post-Infection
Patterson, B.; Francisco, E. B.; Yogendra, R.; Long, E.; Pise, A.; Rodrigues, H.; Hall, E.; Herrera, M.; Parikh, P.; Guevara-Coto, J.; Triche, T.; Scott, P.; Hekmati, S.; Maglinte, D.; Chang, X.; Rodriguez, R.; Mora, J.
10.1101/2021.06.25.449905 — immunology — Posted on 2021-07-09
2886 Rationally designed immunogens enable immune focusing to the SARS-CoV-2 receptor binding motif
Hauser, B. M.; Sangesland, M.; St. Denis, K. J.; Windsor, I. W.; Feldman, J.; Lam, E. C.; Kannegieter, T.; Balazs, A. B.; Lingwood, D.; Schmidt, A. G.
10.1101/2021.03.15.435440 — immunology — Posted on 2021-07-09
2887 Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses
Feldman, J.; Bals, J.; Altomare, C.; Denis, K. S.; Lam, E. C.; Hauser, B. M.; Ronsard, L.; Sangesland, M.; Moreno, T. B.; Okonkwo, V.; Hartojo, N.; Balazs, A. B.; Bajic, G.; Lingwood, D.; Schmidt, A. G.
10.1101/2021.02.02.429458 — immunology — Posted on 2021-07-09
2888 Cerebellar Control of a Unitary Head Direction Sense
Fallahnezhad, M.; Le Mero, J.; Zenelaj, X.; Vincent, J.; Rochefort, C.; Rondi-Reig, L.
10.1101/2021.07.08.451624 — neuroscience — Posted on 2021-07-09
2891 A Mouse Model of Brittle Cornea Syndrome caused by mutation in Zfp469.
Stanton, C. M.; Findlay, A. S.; Drake, C.; Mustafa, M. Z.; Gautier, P.; McKie, L.; Jackson, I. J.; Vitart, V.
10.1101/2021.07.08.451591 — genetics — Posted on 2021-07-09
2893 Non-invasive imaging of gene expression and protein secretion dynamics in living mice
Nourse, J.; Tokalov, S.; Khan, E.; Khokhar, S.; Schott, L. K.; Hinz, L.; Eder, L.; Arnold-Schild, D.; Probst, H. C.; Danckwardt, S.
10.1101/2021.07.08.451623 — cell biology — Posted on 2021-07-09
2894 Lung adenocarcinoma cell-derived exosomal miR-328 promote osteoclastogenesis by targeting Nrp2
Zhang, C. C.; Qin, J.; Yang, L.; Zhu, Z.; Qian, X.; Yang, J.; Su, W.; Wang, F.; Chen, W.; Deng, H.; Wang, Z.
10.1101/2021.07.08.451611 — cancer biology — Posted on 2021-07-09
2897 Short-term diet intervention alters the small non-coding RNA (sncRNA) landscape of human sperm
Vaz, C.; Kermack, A. J.; Burton, M.; Tan, P. F.; Huan, J.; Yoo, T. P.; Donnelly, K.; Wellstead, S. J.; Fisk, H. L.; Houghton, F. D.; Lewis, S.; Chong, Y. S.; Gluckman, P. D.; Cheong, Y.; Macklon, N. S.; Calder, P. C.; Dutta, A.; Godfrey, K. M.; Kumar, P.; Lillycrop, K. A.; Karnani, N.
10.1101/2021.07.08.451257 — bioinformatics — Posted on 2021-07-09
2898 Therapeutic targeting of SETD2-deficient cancer cells with the small-molecule compound RITA
Lopez, K. A.; Sarkar, S.; Seraia, E.; Toffanin, C.; Cooper, C.; Challoumas, M.; Okonjo, F. A.; Jones, G. D. D.; Buffa, F.; Ebner, D.; Humphrey, T. C.
10.1101/2021.07.08.451582 — cell biology — Posted on 2021-07-09
2899 Absolute quantitation of individual SARS-CoV-2 RNA molecules: a new paradigm for infection dynamics and variant differences
Lee, J. Y.; Wing, P. A.; Gala, D. S.; Noerenberg, M.; Jarvelin, A. I.; Titlow, J.; Zhuang, X.; Palmalux, N.; Iselin, L.; Thompson, M. K.; Parton, R. M.; Wainman, A.; Agranoff, D.; James, W.; Castello, A.; McKeating, J. A.; Davis, I.
10.1101/2021.06.29.450133 — microbiology — Posted on 2021-07-09
2900 Defining the Immune Responses for SARS-CoV-2-Human Macrophage Interactions
Mostafa, M.; Yeapuri, P.; Machhi, J.; Olson, K.; Shahjin, F.; Zhou, Y.; Jingjing, L.; Pandey, K.; Acharya, A.; Byrareddy, S.; Mosley, L.; Gendelman, H.
10.1101/2021.07.07.449660 — immunology — Posted on 2021-07-09
2901 Meta-strategy learning in physical problem-solving: the effect of embodied experience
Allen, K. R.; Smith, K.; Bird, L.-A.; Tenenbaum, J. B.; Makin, T.; Cowie, D.
10.1101/2021.07.08.451333 — neuroscience — Posted on 2021-07-09
2905 Multiplexed identification of RAS paralog imbalance as a driver of lung cancer growth
Tang, R.; Shuldiner, E. G.; Kelly, M.; Murray, C. W.; Hebert, J. D.; Andrejka, L.; Tsai, M. K.; Cai, H.; Li, Y.-C.; Wahl, G.; Jackson, P. K.; Petrov, D.; Winslow, M. M.
10.1101/2021.07.08.451571 — cancer biology — Posted on 2021-07-09
2906 Reflective mirror-based line-scan adaptive optics OCT
Pandiyan, V. P.; Jiang, X.; Kuchenbecker, J. A.; Sabesan, R.
10.1101/2021.07.07.451545 — bioengineering — Posted on 2021-07-09
2909 Large-scale deregulation of gene expression by artificial light at night in tadpoles of common toads
Touzot, M.; Lefebure, T.; Lengagne, T.; Secondi, J.; Dumet, A.; Konecny-Dupré, L.; Veber, P.; Navratil, V.; Duchamp, C.; Mondy, N.
10.1101/2021.07.08.451570 — ecology — Posted on 2021-07-09
2910 Cellular toxicity of iHAP1 and DT-061 does not occur through PP2A-B56 targeting
Vit, G.; Duro, J.; Rajendraprasad, G.; Hertz, E. P.; Holland, L.; Weisser, M. B.; McEwan, B.; Lopez-Mendez, B.; Montoya, G.; Mailand, N.; Maeda, K.; Kettenbach, A.; Nilsson, J.
10.1101/2021.07.08.451586 — cell biology — Posted on 2021-07-09
2912 Pre-trial predictors of conflict response efficacy in human dorsolateral prefrontal cortex
Herman, A. B.; Smith, E.; Yates, M.; McKhann, G.; Botvinick, M.; Hayden, B.; Sheth, S.
10.1101/2021.07.07.451322 — neuroscience — Posted on 2021-07-09
2913 Motion/direction-sensitive thalamic neurons project extensively to the middle layers of primary visual cortex
Zhuang, J.; Wang, Y.; Ouellette, N. D.; Turschak, E.; Larsen, R.; Takasaki, K. T.; Daigle, T. L.; Tasic, B.; Waters, J.; Zeng, H.; Reid, R. C.
10.1101/2021.07.07.451534 — neuroscience — Posted on 2021-07-09
2915 Pharmacokinetic Effects of Combined Exposure to Nicotine and THC via E-Cigarettes in Pregnant Rats
Breit, K. R.; Rodriguez, C.; Hussain, S.; Thomas, K.; Zeigler, M.; Gerasimidis, I.; Thomas, J. D.
10.1101/2021.07.07.451537 — pharmacology and toxicology — Posted on 2021-07-09
2916 Local CpG density affects the trajectory of age-associated epigenetic changes
Higham, J.; Zhang, Q.; Walker, R. M.; Harris, S. E.; Howard, D. M.; Hawkins, E. L.; Sandu, A.-L.; Steele, J. D.; Waiter, G. D.; Murray, A. D.; Evans, K. L.; McIntosh, A. M.; Visscher, P. M.; Deary, I. J.; Cox, S. R.; Sproul, D.
10.1101/2021.07.08.451539 — genetics — Posted on 2021-07-09
2919 Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples
Polavarapu, V. K.; Xing, P.; Zhang, H.; Zhao, M.; Mathot, L.; Zhao, L.; Rosen, G.; Swartling, F.; Sjoblom, T.; Chen, X.
10.1101/2021.07.08.450856 — genomics — Posted on 2021-07-09
2920 Long-range single-molecule mapping of chromatin modification in eukaryotes
Weng, Z.; Ruan, F.; Chen, W.; Xie, Z.; Xie, Y.; Zhang, C.; Chen, Z.; Wang, J.; Sun, Y.; Fang, Y.; Guo, M.; Tong, Y.; Li, Y.; Tang, C.
10.1101/2021.07.08.451578 — genomics — Posted on 2021-07-09
2926 Genomic and functional characterization of Pseudomonas aeruginosa-targeting bacteriophages isolated from hospital wastewater
Nordstrom, H. R.; Evans, D. R.; Finney, A. G.; Westbrook, K. J.; Zamora, P. F.; Iovleva, A.; Yassin, M. H.; Bomberger, J. M.; Shields, R. K.; Doi, Y.; Van Tyne, D.
10.1101/2021.07.08.451722 — microbiology — Posted on 2021-07-09
2928 The neutralization potency of anti-SARS-CoV-2 therapeutic human monoclonal antibodies is retained against novel viral variants
Makdasi, E.; Zvi, A.; Alcalay, R.; Noy-Porat, T.; Peretz, E.; Mechaly, A.; Levy, Y.; Epstein, E.; Chitlaru, T.; Tennenhouse, A.; Aftalion, M.; Gur, D.; Paran, N.; Tamir, H.; Zimhony, O.; Weiss, S.; Mandelboim, M.; Mendelson, E.; Zuckerman, N.; Nemet, I.; Kliker, L.; Yitzhaki, S.; Shapira, S. C.; Israely, T.; Fleishman, S. J.; Mazor, O.; Rosenfeld, R.
10.1101/2021.04.01.438035 — immunology — Posted on 2021-07-09
2932 metaboprep: an R package for pre-analysis data description and processing.
Hughes, D. A.; Taylor, K. A.; McBride, N.; Lee, M. A.; Mason, D.; Lawlor, D. A.; Timpson, N. J.; Corbin, L. J.
10.1101/2021.07.07.451488 — bioinformatics — Posted on 2021-07-09
2935 Ecological inference using data from accelerometers needs careful protocols
Garde, B.; Wilson, R. P.; Fell, A.; Cole, N.; Tatayah, V.; Holton, M. D.; Rose, K. A. R.; Metcalfe, R. S.; Robotka, H.; Wikelski, M.; Tremblay, F.; Whelan, S.; Elliott, K. H.; Shepard, E.
10.1101/2021.07.07.451487 — animal behavior and cognition — Posted on 2021-07-09
2936 Genome Profiling of SARS-CoV-2 in Indonesia, ASEAN and the Neighbouring East Asian Countries: Features, Challenges and Achievements
Cahyani, I.; Putro, E. W.; Ridwanuloh, A. M.; Wibowo, S.; Hariyatun, H.; Syahputra, G.; Akbariani, G.; Utomo, A. R.; Ilyas, M.; Loose, M. W.; Kusharyoto, W.; Susanti, S.
10.1101/2021.07.06.451270 — genomics — Posted on 2021-07-09
2940 The characteristics of the HIV-1 Env glycoprotein contribute to viral pathogenesis
Perez-Yanes, S.; Pernas, M.; Marfil, S.; Cabrera-Rodriguez, R.; Ortiz, R.; Rovirosa, C.; Estevez-Herrera, J.; Olivares, I.; Casado, C.; Lopez-Galindez, C.; Blanco, J.; Valenzuela-Fernandez, A.
10.1101/2021.07.07.451566 — microbiology — Posted on 2021-07-09
2941 Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eEF2K
Beretta, S.; Ponzoni, L.; Gritti, L.; Scalmani, P.; Mantegazza, M.; Sala, M.; Verpelli, C.; Sala, C.
10.1101/2021.07.07.451562 — neuroscience — Posted on 2021-07-09
2943 Dissociable Multi-scale Patterns of Development in Personalized Brain Networks
Pines, A. R.; Larsen, B.; Cui, Z.; Sydnor, V. J.; Bertolero, M. A.; Adebimpe, A.; Alexander-Bloch, A. F.; Davatzikos, C.; Fair, D. A.; Gur, R. C.; Gur, R. E.; Li, H.; Milham, M. P.; Moore, T. M.; Murtha, K.; Parkes, L.; Thompson-Schill, S. L.; Shanmugan, S.; Shinohara, R. T.; Weinstein, S. M.; Bassett, D. S.; Fan, Y.; Satterthwaite, T. D.
10.1101/2021.07.07.451458 — neuroscience — Posted on 2021-07-09
2948 The disease associated Tau35 fragment has an increased propensity to aggregate compared to full-length tau
Lyu, C.; Da Vela, S.; Al-Hilaly, Y. K.; Marshall, K.; Thorogate, R.; Svergun, D.; Serpell, L.; Pastore, A.; Hanger, D. P.
10.1101/2021.07.08.451675 — biophysics — Posted on 2021-07-09
2950 The Thousand Polish Genomes Project- a national database of Polish variant allele frequencies
Kaja, E.; Lejman, A.; Sielski, D.; Sypniewski, M.; Gambin, T. L.; Suchocki, T.; Dawidziuk, M.; Golik, P.; Wojtaszewska, M.; Stepien, M.; Szyda, J.; Lisiak-Teodorczyk, K.; Wolbach, F.; Kołdziejska, D.; Ferdyn, K.; Wozna, A.; Zytkiewicz, M.; Bodora-Troinska, A.; Elikowski, W.; Krol, Z.; Zaczynski, A.; Pawlak, A.; Gil, R.; Wierzba, W.; Dobosz, P.; Zawadzka, K.; Zawadzki, P.; Sztromwasser, P.
10.1101/2021.07.07.451425 — genomics — Posted on 2021-07-09
2951 Single Cell Transcriptomics Reveals Cell Type Specific Diversification in Human Heart Failure
Koenig, A. L.; Shchukina, I.; Andhey, P. S.; Zaitsev, K.; Lai, L.; Amrute, J.; Bajpai, G.; Bredemeyer, A.; Smith, G.; Jones, C.; Terrebonne, E.; Rentschler, S. L.; Artyomov, M. N.; Lavine, K. J.
10.1101/2021.07.06.451312 — genomics — Posted on 2021-07-09
2952 A geospatial mapping pipeline for ecologists
van den Hoogen, J.; Robmann, N.; Routh, D.; Lauber, T.; van Tiel, N.; Danylo, O.; Crowther, T. W.
10.1101/2021.07.07.451145 — ecology — Posted on 2021-07-09
2953 Skilful decadal-scale prediction of fish habitat and distribution shifts
Payne, M. R.; Miesner, A. K.; Keenlyside, N.; Yang, S.; Yeager, S. G.; Danabasoglu, G.; Matei, D.
10.1101/2021.07.07.451446 — ecology — Posted on 2021-07-09
2956 The variability in potential biomarkers for cochlear synaptopathy after recreational noise exposure
Vande Maele, T.; Keshishzadeh, S.; De Poortere, N.; Dhooge, I.; Keppler, H.; Verhulst, S.
10.1101/2021.01.17.427007 — neuroscience — Posted on 2021-07-09
2957 The lateral entorhinal cortex is a hub for local and global dysfunction in pre-tauopathy states
Mandino, F.; Yeow, L. Y.; Bi, R.; Lee, S.; Bae, H. G.; Baek, S. H.; Lee, C. Y.; Mohammad, H.; Teoh, C. L.; Horien, C. L.; Lee, J.; Lai, M. K. P.; Jung, S.; Yu, F.; Olivo, M.; Gigg, J.; Grandjean, J.
10.1101/2020.04.03.022590 — neuroscience — Posted on 2021-07-09
2958 NHE6-Depletion Corrects ApoE4-Mediated Synaptic Impairments and Reduces Amyloid Plaque Load
Pohlkamp, T.; Xian, X.; Wong, C. H.; Durakoglugil, M. S.; Werthmann, G. C.; Saido, T. C.; Evers, B. M.; White, C. L.; Connor, J.; Hammer, R. E.; Herz, J.
10.1101/2021.03.22.436385 — neuroscience — Posted on 2021-07-09
2960 EEG biomarkers of free recall
Katerman, B. S.; Li, Y.; Pazdera, J. K.; Keane, C.; Kahana, M. J.
10.1101/2021.04.30.442192 — neuroscience — Posted on 2021-07-09
2963 A predictive processing model of episodic memory and time perception
Fountas, Z.; Sylaidi, A.; Nikiforou, K.; Seth, A.; Shanahan, M.; Roseboom, W.
10.1101/2020.02.17.953133 — neuroscience — Posted on 2021-07-09
2967 Emergent collective locomotion in an active polymer model of entangled worm blobs
Nguyen, C.; Ozkan-Aydin, Y.; Tuazon, H.; Goldman, D. I.; Bhamla, M. S.; Peleg, O.
10.1101/2021.07.08.451507 — biophysics — Posted on 2021-07-09
2972 Structural modeling of the hERG potassium channel and associated drug interactions
Maly, J.; Emigh, A.; DeMarco, K.; Furutani, K.; Sack, J. T.; Clancy, C.; Vorobyov, I.; Yarov-Yarovoy, V.
10.1101/2021.07.08.451699 — biophysics — Posted on 2021-07-09
2973 Structure and Mechanism of Hedgehog Acyl Transferase
Coupland, C. E.; Andrei, S. A.; Ansell, T. B.; Carrique, L.; Kumar, P.; Sefer, L.; Schwab, R. A.; Byrne, E. F. X.; Pardon, E.; Steyaert, J.; Magee, A. I.; Sansom, M. S. P.; Tate, E. W.; Siebold, C.
10.1101/2021.07.08.451580 — biophysics — Posted on 2021-07-09
2979 Dug: A Semantic Search Engine Leveraging Peer-Reviewed Literature to Span Biomedical Data Repositories
Waldrop, A. M.; Cheadle, J. B.; Bradford, K.; Braswell, N. T.; Watson, M.; Crerar, A.; Ball, C.; Kebede, Y.; Schreep, C.; Linebaugh, P. J.; Hiles, H.; Boyles, R.; Bizon, C.; Krishnamurthy, A.; Cox, S.
10.1101/2021.07.07.451461 — bioinformatics — Posted on 2021-07-09
2980 Efficient gradient boosting for prognostic biomarker discovery
Li, K.; Yao, S.; Zhang, Z.; Cao, B.; Wilson, C.; Kuan, P.; Zhu, R.; Wang, X.
10.1101/2021.07.06.451263 — bioinformatics — Posted on 2021-07-09
2981 Novel drivers of virulence in Clostridioides difficile identified via context-specific metabolic network analysis
Jenior, M. L.; Leslie, J. L.; Powers, D. A.; Garrett, E. M.; Walker, K. A.; Dickenson, M. E.; Petri, W. A.; Tamayo, R.; Papin, J. A.
10.1101/2020.11.09.373480 — bioengineering — Posted on 2021-07-09
2982 The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics
Kollewe, A.; Chubanov, V.; Tseung, F. T.; Haupt, A.; Müller, C. S.; Bildl, W.; Schulte, S.; Nicke, A.; Fakler, B.; Gudermann, T.
10.1101/2021.07.09.451738 — biochemistry — Posted on 2021-07-09
2983 Structure of mycobacterial CIII2CIV2 respiratory supercomplex bound to the tuberculosis drug candidate telacebec (Q203)
Yanofsky, D. J.; Di Trani, J. M.; Krol, S.; Abdelaziz, R.; Bueler, S. A.; Imming, P.; Brzezinski, P.; Rubinstein, J. L.
10.1101/2021.07.06.451285 — biochemistry — Posted on 2021-07-09
2985 Epigenetic Regulation of Nuclear Lamina-Associated Heterochromatin by HAT1 and the Acetylation of Newly Synthesized Histones
Popova, L. V.; Nagarajan, P.; Lovejoy, C. M.; Sunkel, B. D.; Gardner, M. L.; Wang, M.; Freitas, M. A.; Stanton, B.; Parthun, M. R.
10.1101/2021.06.28.450212 — genomics — Posted on 2021-07-09
2986 Expansion of mutation-driven haematopoietic clones is associated with insulin resistance and low HDL-cholesterol in individuals with obesity
van Deuren, R. C.; Andersson-Assarsson, J. C.; Kristensson, F. M.; Steehouwer, M.; Sjöholm, K.; Svensson, P.-A.; Pieterse, M.; Gilissen, C.; Taube, M.; Jacobson, P.; Perkins, R.; Brunner, H. G.; Netea, M. G.; Peltonen, M.; Carlsson, B.; Hoischen, A.; Carlsson, L. M.
10.1101/2021.05.12.443095 — genomics — Posted on 2021-07-09
2987 Multiplex genotyping method to validate the multiallelic genome editing outcomes using machine learning-assisted long-read sequencing
Kuno, A.; Ikeda, Y.; Ayabe, S.; Kato, K.; Sakamoto, K.; Suzuki, S.; Morimoto, K.; Wakimoto, A.; Mikami, N.; Ishida, M.; Iki, N.; Hamada, Y.; Takemura, M.; Daitoku, Y.; Tanimoto, Y.; Dinh, T. T.; Murata, K.; Hamada, M.; Muratani, M.; Yoshiki, A.; Sugiyama, F.; Takahashi, S.; Mizuno, S.
10.1101/2020.12.14.422641 — genomics — Posted on 2021-07-09
2988 A mutational gradient drives somatic mutation accumulation in mitochondrial DNA and influences germline polymorphisms and genome composition
Sanchez-Contreras, M.; Sweetwyne, M. T.; Kohrn, B. F.; Tsantilas, K. A.; Fredrickson, J.; Whitson, J. A.; Campbell, M. D.; Rabinovitch, P. S.; Marcinek, D. J.; Kennedy, S. R.
10.1101/2021.06.18.448725 — genomics — Posted on 2021-07-09
2990 Gene co-expression reveals the modularity and integration of C4 and CAM in Portulaca
Gilman, I. S.; Moreno-Villena, J. J.; Lewis, Z. R.; Goolsby, E. W.; Edwards, E. J.
10.1101/2021.07.07.451465 — evolutionary biology — Posted on 2021-07-09
2991 Soil conditions drive belowground trait space in temperate agricultural grasslands
Lachaise, T. P.-A.; Bergmann, J.; Hoelzel, N.; Klaus, V.; Kleinebecker, T.; Rillig, M. C.; van Kleunen, M.
10.1101/2021.07.07.450881 — ecology — Posted on 2021-07-09
2994 Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins
Nowicka, U.; Chroscicki, P.; Stroobants, K.; Sladowska, M.; Turek, M.; Uszczynska-Ratajczak, B.; Kundra, R.; Goral, T.; Perni, M.; Dobson, C. M.; Vendruscolo, M.; Chacinska, A.
10.1101/2021.05.02.442342 — molecular biology — Posted on 2021-07-09
2997 Post-transcriptional regulation of Leishmania fitness gain
Piel, L.; Rajan, K. S.; Bussotti, G.; Varet, H.; Legendre, R.; Proux, C.; Douche, T.; Giai Gianetto, Q.; Chaze, T.; Vojtkova, B.; Gordon-Bar, N.; Doniger, T.; Cohen-Chalamish, S.; Rengaraj, P.; Besse, C.; Boland, A.; Sadlova, J.; Deleuze, J.-F.; Matondo, M.; Unger, R.; Volf, P.; Michaeli, S.; Pescher, P.; Spaeth, G. F.
10.1101/2021.03.22.436378 — microbiology — Posted on 2021-07-09
2998 Micronutrient supplements with iron promote disruptive protozoan and fungal communities in the developing infant gut
Popovic, A.; Bourdon, C.; Wang, P. W.; Guttman, D. S.; Soofi, S.; Bhutta, Z. A.; Bandsma, R. H. J.; Parkinson, J.; Pell, L. G.
10.1101/2021.07.06.451346 — microbiology — Posted on 2021-07-09
3000 Noradrenergic control of non-REM sleep substates
Osorio-Forero, A.; Cardis, R.; Vantomme, G.; Guillaume-Gentil, A.; Katsioudi, G.; Fernandez, L. M.; Luthi, A.
10.1101/2021.03.08.434399 — neuroscience — Posted on 2021-07-09
3003 Stimulus-induced narrowband gamma oscillations are test-retest reliable in healthy elderly in human EEG
Kumar, W. S.; Manikandan, K.; Murty, D. V. P. S.; Ramesh, R. G.; Purokayastha, S.; Javali, M.; Rao, N. P.; Ray, S.
10.1101/2021.07.06.451226 — neuroscience — Posted on 2021-07-09
3008 The evolution of two distinct strategies of moth flight
Aiello, B. R.; Sikandar, U. B.; Minoguchi, H.; Bhinderwala, B.; Hamilton, C. A.; Kawahara, A. Y.; Sponberg, S.
10.1101/2020.10.27.358176 — physiology — Posted on 2021-07-09
3010 Somatic hypomethylation of pericentromeric SST1 repeats and tetraploidization in human colorectal cancer cells
Gonzalez, B.; Navarro-Jimenez, M.; Alonso-De Gennaro, M. J.; Jansen, S. M.; Granada, I.; Perucho, M.; Alonso, S.
10.1101/2021.02.19.431645 — cancer biology — Posted on 2021-07-09
3011 FANCD2 directly inhibits DNA2 nuclease at stalled replication forks and acts as a RAD51 mediator in strand exchange
Liu, W.; Roubal, I.; Polaczek, P.; Meng, Y.; Choe, W.-c.; Caron, M. C.; Sedgeman, C. A.; Xi, Y.; Liu, C.; Wu, Q.; Zheng, L.; Masson, J. Y.; Shen, B.; Campbell, J. L.
10.1101/2021.07.08.450798 — biochemistry — Posted on 2021-07-09
3013 The geometry of domain-general performance monitoring representations in the human medial frontal cortex
Fu, Z.; Beam, D.; Chung, J. M.; Reed, C. M.; Mamelak, A. N.; Adolphs, R.; Rutishauser, U.
10.1101/2021.07.08.451594 — neuroscience — Posted on 2021-07-08
3015 Positive selection and enhancer evolution shaped lifespan and body mass in great apes
Tejada-Martinez, D.; Avelar, R. A.; de Magalhaes, J. P.; Lopes, I.; Zhang, B.; Novoa, G.; Trizzino, M.
10.1101/2021.07.08.451631 — genomics — Posted on 2021-07-08
3022 Fully resolved assembly of Cryptosporidium parvum
Menon, V. K.; Okhuysen, P. C.; Chappell, C.; Mahmoud, M.; Meng, Q.; Vee, V.; Doddapaneni, H.; Han, Y.; Salvi, S.; Bhamidipati, S.; Kottapalli, K.; Weissenberger, G.; Shen, H.; Ross, M. C.; Hoffman, K. L.; Cregeen, S. J.; Muzny, D. M.; Metcalf, G. A.; Gibbs, R. A.; Petrosino, J. F.; Sedlazeck, F. J.
10.1101/2021.07.07.451495 — genomics — Posted on 2021-07-08
3023 Growth temperature is the principal driver of chromatinization in archaea
Hocher, A.; Borrel, G.; Fadhlaoui, K.; Brugere, J.-F.; Gribaldo, S.; Warnecke, T.
10.1101/2021.07.08.451601 — evolutionary biology — Posted on 2021-07-08
3025 SPE-51, a sperm secreted protein with an Immunoglobulin-like domain, is required for sperm-egg fusion in C. elegans
Mei, X.; Druzhinina, M.; Dharia, S.; Krauchunas, A. R.; Ni, J.; Singaravelu, G.; Gu, S. G.; Shakes, D. C.; Grant, B. D.; Singson, A. W.
10.1101/2021.07.07.451548 — developmental biology — Posted on 2021-07-08
3026 Establishment of 3D chromatin structure after fertilization and the metabolic switch at the morula-to-blastocyst transition require CTCF
Andreu, M. J.; Alvarez-Franco, A.; Portela, M.; Gimenez-Llorente, D.; Cuadrado, A.; Badia-Careaga, C.; Tiana, M.; Losada, A.; Manzanares, M.
10.1101/2021.07.07.451492 — developmental biology — Posted on 2021-07-08
3027 The EGF-motif containing protein SPE-36 is a secreted protein required for sperm function at fertilization in C. elegans
Krauchunas, A. R.; Marcello, M. R.; Looper, A.; Mei, X.; Putiri, E.; Singaravelu, G.; Ahmed, I. I.; Singson, A.
10.1101/2021.07.07.451551 — developmental biology — Posted on 2021-07-08
3029 Ultrastructural analysis of nasopharyngeal epithelial cells from patients with SARS-CoV-2 infection
Saraiva, K. L.; Vasconcelos, L. R.; Bezerra, M. F.; Arcoverde, R. M.; Brandao-Filho, S. P.; Ayres, C. F.; Figueiredo, R. C.; Pereira-Neves, A.
10.1101/2021.07.08.451607 — cell biology — Posted on 2021-07-08
3030 Cytoplasmic Switch of ARS2 Isoforms Promotes Nonsense-Mediated mRNA Decay and Arsenic Sensitivity
Mesa-Perez, M.; Hamilton, P.; Miranda-Rodriguez, A.; Brodie, N.; O'Sullivan, C.; Christie, J.; Ryan, B.; Chow, R.; Goodlett, D.; Nelson, C. J.; Howard, P.
10.1101/2021.07.08.451683 — molecular biology — Posted on 2021-07-08
3031 Combinations of Peptides Synergistically Activate the Regenerative Capacity of Skin Cells In Vitro
Flagler, M. J.; Tamura, M.; Laughlin, T.; Hartman, S.; Ashe, J.; Adams, R.; Kozak, K.; Cresswell, K.; Mullins, L.; Jarrold, B. B.; Isfort, R. J.; Sherrill, J. D.
10.1101/2021.07.07.451479 — molecular biology — Posted on 2021-07-08
3033 Founder cell configuration drives competitive outcome within colony biofilms
Eigentler, L.; Kalamara, M.; Ball, G.; MacPhee, C. E.; Stanley-Wall, N. R.; Davidson, F. A.
10.1101/2021.07.08.451560 — microbiology — Posted on 2021-07-08
3036 Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer
Mujal, A. M.; Combes, A. J.; Rao, A. A.; Binnewies, M.; Samad, B.; Tsui, J.; Boissonnas, A.; Pollack, J. L.; Arguello, R. J.; Ruhland, M. K.; Barry, K. C.; Chan, V.; Krummel, M. F.
10.1101/2021.07.07.451502 — immunology — Posted on 2021-07-08
3038 Subspace alignment as a mechanism for binding
Fine, J. M.; Yoo, S. B. M.; Ebitz, B.; Hayden, B.
10.1101/2021.07.07.451472 — neuroscience — Posted on 2021-07-08
3040 Nicotine dependence and functional connectivity of insular cortex subregions
Ghahremani, D. G.; Pochon, J.-B.; Perez Diaz, M.; Tyndale, R. F.; Dean, A. C.; London, E. D.
10.1101/2021.07.07.451360 — neuroscience — Posted on 2021-07-08
3041 A natural marmoset model of genetic generalized epilepsy.
Yang, X.; Chen, Z.; Wang, Z.; He, G.; Li, Z.; Shi, Y.; Gong, N.; Zhao, B.; Takahashi, E.; Li, W.
10.1101/2021.07.07.451379 — neuroscience — Posted on 2021-07-08
3044 Evaluation of intranasal nafamostat or camostat for SARS-CoV-2 chemoprophylaxis in Syrian golden hamsters
Neary, M.; Box, H.; Sharp, J.; Tatham, L.; Curley, P.; Herriott, J.; Kijak, E.; Arshad, U.; Hobson, J. J.; Rajoli, R. K.; Pertinez, H.; Valentijn, A.; Dhaliwal, K.; McCaughan, F.; Rannard, S. P.; Kipar, A.; Stewart, J. P.; Owen, A.
10.1101/2021.07.08.451654 — pharmacology and toxicology — Posted on 2021-07-08
3046 Differential effects of high versus low linear energy transfer (LET) radiation on type-I interferon (IFNβ) and TREX1 responses
Miles, D.; Cao, N.; Sandison, G.; Stewart, R. D.; Moffitt, G.; Pulliam, T. H.; Parvathaneni, U.; Goff, P.; Nghiem, P.; Stantz, K.
10.1101/2021.07.07.451516 — cancer biology — Posted on 2021-07-08
3051 Citizen-science surveillance of triazole-resistant Aspergillus fumigatus in UK residential garden soils
Shelton, J. M.; Collins, R.; Uzzell, C. B.; Alghamdi, A.; Dyer, P. S.; Singer, A. C.; Fisher, M. C.
10.1101/2021.07.08.451577 — microbiology — Posted on 2021-07-08
3053 Antibody and T cell memory immune response after two doses of the BNT162b2 mRNA vaccine in older adults with and without prior SARS-CoV-2 infection
Demaret, J.; Corroyer-Simovic, B.; Alidjinou, E. K.; Goffard, A.; Trauet, J.; Miczek, S.; Vuotto, F.; Dendooven, A.; Huvent-Grelle, D.; Podvin, J.; Dreuil, D.; Faure, K.; Deplanque, D.; Bocket, L.; Duhamel, A.; Labreuche, J.; Sobaszek, A.; Puisieux, F.; Labalette, M.; Lefevre, G.
10.1101/2021.07.08.451426 — immunology — Posted on 2021-07-08
3054 In Silico Defined SARS-CoV2 Epitopes May Not Predict Immunogenicity to COVID19
Pan, K.; Chiu, Y.; Chen, M.; Wang, J.; Lai, I.; Singh, S.; Shaw, R. M.; Yee, C.
10.1101/2021.07.08.451555 — immunology — Posted on 2021-07-08
3055 Structure of a germline-like human antibody defines a neutralizing epitope on the SARS-CoV-2 spike NTD
Altomare, C. G.; Adelsberg, D. C.; Carreno, J. M.; Sapse, I. A.; Amanat, F.; Ellebedy, A.; Simon, V.; Krammer, F.; Bajic, G.
10.1101/2021.07.08.451649 — immunology — Posted on 2021-07-08
3057 LptB2FG is an ABC transporter with Adenylate Kinase activity regulated by LptC/A recruitment
Baeta, T.; Giandoreggio-Barranco, K.; Ayala, I.; Moura, E. C.; Sperandeo, P.; Polissi, A.; Simorre, J.-P.; Laguri, C.
10.1101/2021.07.08.451440 — biochemistry — Posted on 2021-07-08
3059 Structure of the integrin receptor M2 headpiece in complex with a function-modulating nanobody
Jensen, R. K.; Pedersen, H.; Lorentzen, J.; Laursen, N. S.; Vorup-Jensen, T.; Andersen, G. R.
10.1101/2021.07.07.451531 — immunology — Posted on 2021-07-08
3060 Gating mechanism of human N-type voltage-gated calcium channel
Dong, Y.; Gao, Y.; Xu, S.; Wang, Y.; Yu, Z.; Li, Y.; Li, B.; Yang, B.; Zhang, X. C.; Jiang, D.; Huang, Z.; Zhao, Y.
10.1101/2021.07.08.451561 — neuroscience — Posted on 2021-07-08
3063 Patch-seq of mouse DRG neurons reveals candidate genes for specific mechanosensory functions
Parpaite, T.; Brosse, L.; Sejourne, N.; Laur, A.; Mechioukhi, Y.; Delmas, P.; Coste, B.
10.1101/2021.07.07.451447 — neuroscience — Posted on 2021-07-08
3065 All driven by energy demand? Integrative comparison of metabolism of Enterococcus faecalis wildtype and a glutamine synthase mutant
Loghmani, S. B.; Zitzow, E.; Koh, G. C.-C.; Ulmer, A.; Veith, N.; Großeholz, R.; Rossnagel, M.; Loesch, M.; Aebersold, R.; Kreikemeyer, B.; Fiedler, T.; Kummer, U.
10.1101/2021.07.07.451427 — systems biology — Posted on 2021-07-08
3066 Genome binning of viral entities from bulk metagenomics data
Johansen, J.; Plichta, D. R.; Nissen, J. N.; Jespersen, M. L.; Shah, S. A.; Deng, L.; Stokholm, J.; Bisgaard, H.; Nielsen, D. S.; Sorensen, S. J.; Rasmussen, S.
10.1101/2021.07.07.451412 — genomics — Posted on 2021-07-08
3068 Calpains are required for efficient microtubule detyrosination
Bär, J.; Popp, Y.; Koudelka, T.; Tholey, A.; Mikhaylova, M.
10.1101/2021.07.08.451629 — cell biology — Posted on 2021-07-08
3069 Autoimmunity increases susceptibility to and mortality from sepsis
Jensen, I. J.; Jensen, S. N.; McGonagill, P. W.; Griffith, T. S.; Mangalam, A. K.; Badovinac, V. P.
10.1101/2021.07.06.451335 — immunology — Posted on 2021-07-08
3073 Hippocampal Astrocytes Encode Reward Location
Doron, A.; Rubin, A.; Benmelech-Chovav, A.; Benaim, N.; Carmi, T.; Kreisel, T.; Ziv, Y.; Goshen, I.
10.1101/2021.07.07.451434 — neuroscience — Posted on 2021-07-08
3074 Virtual meetings promise to eliminate the geographical and administrative barriers and increase accessibility, diversity, and inclusivity
Wu, J.; Rajesh, A.; Huang, Y.-N.; Chhugani, K.; Acharya, R.; Peng, K.; Johnson, R. D.; Fiscutean, A.; Robles-Espinoza, C. D.; De La Vega, F. M.; Bao, R.; Mangul, S.
10.1101/2021.07.07.451408 — scientific communication and education — Posted on 2021-07-08
3080 SARS-CoV-2 Neurotropism and Single Cell Responses in Brain Organoids Containing Innately Developing Microglia
Samudyata, ; Oliveira, A. O.; Malwade, S.; de Sousa, N. R.; Goparaju, S. K.; Orhan, F.; Steponaviciute, L.; Sheridan, S. D.; Perlis, R. H.; Rothfuchs, A. G.; Sellgren-Majkowitz, C.
10.1101/2021.07.07.451463 — neuroscience — Posted on 2021-07-08
3081 Impact of Fkbp5 x Early Life Adversity x Sex in Humanized Mice on Multidimensional Stress Responses and Circadian Rhythmicity
Nold, V.; Del Prete, D.; Blasius, A.; Harris, I.; Koros, E.; Peleh, T.; Hengerer, B.; Kolassa, I. T.; Slezak, M.; Alleres, K. A.
10.1101/2021.07.06.450863 — neuroscience — Posted on 2021-07-08
3083 A billion synthetic 3D-antibody-antigen complexes enable unconstrained machine-learning formalized investigation of antibody specificity prediction
Robert, P. A.; Akbar, R.; Frank, R.; Pavlovic, M.; Widrich, M.; Snapkov, I.; Chernigovskaya, M.; Scheffer, L.; Slabodkin, A.; Mehta, B. B.; Vu, M. H.; Prosz, A.; Abram, K.; Olar, A.; Miho, E.; Haug, D. T. T.; Lund-Johansen, F.; Hochreiter, S.; Hobaek Haff, I.; Klambauer, G.; Sandve, G. K.; Greiff, V.
10.1101/2021.07.06.451258 — immunology — Posted on 2021-07-08
3084 GLOBAL EFFECTS OF A PD RISK-SNP AT THE ALPHA-SYNUCLEIN LOCUS
Prahl, J. D.; Pierce, S. E.; van der Schans, E. J.; Coetzee, G. A.; Tyson, T.
10.1101/2021.07.06.451330 — neuroscience — Posted on 2021-07-08
3086 Stimulus-induced narrowband gamma oscillations are test-retest reliable in healthy elderly in human EEG
Ray, S.; Murty, D. V. P. S.; Kumar, W. S.; Manikandan, K.; Ramesh, R. G.; Purokayastha, S.; Javali, M.; Rao, N. P.
10.1101/2021.07.06.451226 — neuroscience — Posted on 2021-07-08
3087 A cell-sorting-based nano-scale pipeline for cell-type-specific proteomics in plants
Wang, H.; Li, R.; Rong, J.; Sang, T.; Kim, C.; Song, C.-P.; Dai, S.; Hsu, C.-C.; Wang, P.
10.1101/2021.07.06.451220 — plant biology — Posted on 2021-07-08
3088 Arabidopsis Topless-related 1 mitigates physiological damage and growth penalties of induced immunity
Griebel, T.; Lapin, D.; Locci, F.; Kracher, B.; Bautor, J.; Qiu, J.; Concia, L.; Benhamed, M.; Parker, J. E.
10.1101/2021.07.07.451397 — plant biology — Posted on 2021-07-08
3092 Efficient gradient boosting for prognostic biomarker discovery
Li, K.; Yao, S.; Zhang, Z.; Cao, B.; Wilson, C.; Kuan, P.; Zhu, R.; Wang, X.
10.1101/2021.07.06.451263 — bioinformatics — Posted on 2021-07-08
3097 Spatial heterogeneity in forest carbon storage affects priorities for reforestation
Chaplin-Kramer, R.; Johnson, J. A.; Sharp, R. P.; Chatterton, J.; Weil, C.; Baccini, A.; Sim, S.
10.1101/2021.07.06.450936 — ecology — Posted on 2021-07-08
3101 Quantifying phase separation property of chromatin associated proteins under physiological conditions using anti-1,6-hexanediol index
Shi, M.; You, K.; Chen, T.; Hou, C.; Liang, Z.; Liu, M.; Wang, J.; Wei, T.; Qin, J.; Chen, Y.; Zhang, M. Q.; Li, T.
10.1101/2020.12.07.415489 — cell biology — Posted on 2021-07-08
3104 Convergent consequences of parthenogenesis on stick insect genomes
Jaron, K. S.; Parker, D. J.; Anselmetti, Y.; Tran Van, P.; Bast, J.; Dumas, Z.; Figuet, E.; Francois, C. M.; Hayward, K.; Rossier, V.; Simion, P.; Robinson-Rechavi, M.; Galtier, N.; Schwander, T.
10.1101/2020.11.20.391540 — evolutionary biology — Posted on 2021-07-08
3105 Negative modulation of macroautophagy by HERPUD1 is counteracted by an increased ER-lysosomal network with impact in drug-induced stress cell survival
Vargas, G.; Cortes, O. H.; Arias-Munoz, E. N.; Hernandez-Galaz, S. F.; Cerda-Troncoso, C.; Hernandez-Torres, L.; Gonzalez, A. E.; Tatham, M.; Bustamante, H. A.; Retamal, C. E.; Cancino, J.; Varas-Godoy, M.; Hay, R. T.; Rojas-Fernandez, A.; Cavieres, V. A.; Burgos, P. V.
10.1101/2021.06.14.447273 — cell biology — Posted on 2021-07-08
3106 Members of a highly widespread bacteriophage family are hallmarks of metabolic syndrome gut microbiomes
de Jonge, P. A.; Wortelboer, K.; Scheithauer, T. P. M.; van den Born, B.-J. H.; Zwinderman, A. H.; Nobrega, F. L.; Dutilh, B. E.; Nieuwdorp, M.; Herrema, H.
10.1101/2021.03.30.437683 — microbiology — Posted on 2021-07-08
3108 Interrogation of genome-wide, experimentally dissected gene regulatory networks reveals mechanisms underlying dynamic cellular state control
Tan, X.; Worley, J.; Turunen, M.; Wong, K.; Fernandez, E. C.; Paull, E.; Jones, S.; Wang, J.; Noh, H.; Salvatori, B.; Chavez, A.; Califano, A.
10.1101/2021.06.28.449297 — systems biology — Posted on 2021-07-08
3110 The molecular mechanism of cytoadherence to placenta or tumor cells through VAR2CSA from Plasmodium falciparum
Wang, W.; Wang, Z.; Yang, X.; Gao, Y.; Zhang, X.; Wang, W.; Zhao, L.; Zhang, J.; Jing, Q.; Xu, Q.; Cao, L.; Tian, Y.; Dai, A.; Sun, J.; Sun, L.; Jiang, L.; Chen, Z.; Wang, L.
10.1101/2021.07.06.451098 — biophysics — Posted on 2021-07-08
3111 Characterization of the radiation desiccation response regulon of the radioresistant bacterium Deinococcus radiodurans by integrative genomic analyses.
Eugenie, N.; Zivanovic, Y.; Lelandais, G.; Coste, G.; Bouthier de la Tour, C.; Bentchikou, E.; Servant, P.; Confalonieri, F.
10.1101/2021.07.07.451423 — genomics — Posted on 2021-07-08
3112 MG132 induces progerin clearance and improves disease phenotypes in fibroblasts of patients affected with Hutchinson-Gilford Progeria-like syndromes
HARHOURI, K.; CAU, P.; CASEY, F.; GUEDENON, K. M.; DOUBAJ, Y.; VAN MALDERGEM, L.; MEJIA-BALTODANO, G.; Bartoli, C.; De SANDRE-GIOVANNOLI, A.; LEVY, N.
10.1101/2021.04.14.439612 — genetics — Posted on 2021-07-08
3117 Spatially resolved transcriptomics reveals unique gene signatures associated with human temporal cortical architecture and Alzheimer's pathology
Chen, S.; Chang, Y.; Li, L.; Acosta, D.; Morrison, C.; Wang, C.; Julian, D.; Hester, M. E.; Serrano, G. E.; Beach, T. G.; Ma, Q.; Fu, H.
10.1101/2021.07.07.451554 — neuroscience — Posted on 2021-07-08
3122 Ultra-fast insulin-pramlintide co-formulation for improved glucose management in diabetic rats
Maikawa, C. L.; Chen, P. C.; Vuong, E. T.; Nguyen, L. T.; Mann, J. L.; d'Aquino, A. I.; Lal, R. A.; Maahs, D. M.; Buckingham, B. A.; Appel, E. A.
10.1101/2021.04.12.439573 — bioengineering — Posted on 2021-07-07
3123 The myopathic transcription factor DUX4 induces the production of truncated RNA-bindingproteins in human muscle cells
Campbell, A. E.; Dyle, M. C.; Calviello, L.; Matheny, T.; Cortazar, M. A.; Forman, T.; Fu, R.; Gillen, A. E.; Floor, S. N.; Jagannathan, S.
10.1101/2021.06.28.450189 — genomics — Posted on 2021-07-07
3126 Size-dependent protein segregation creates a spatial switch for Notch signaling and function
Kwak, M.; Southard, K. M.; Kim, N. H.; Gopalappa, R.; Kim, W. R.; An, M.; Lee, H. J.; Kang, M. K.; Choi, S. H.; Farlow, J.; Georgakopoulos, A.; Robakis, N. K.; Seo, D.; Kim, H. B.; Kim, Y. H.; Cheon, J.; Gartner, Z. J.; Jun, Y.-w.
10.1101/2020.06.28.176560 — cell biology — Posted on 2021-07-07
3128 Egress of human cytomegalovirus through multivesicular bodies
Flomm, F. J.; Soh, T. K.; Schneider, C.; Britt, H. M.; Thalassinos, K.; Pfitzner, S.; Reimer, R.; Gruenewald, K.; Bosse, J. B.
10.1101/2020.12.31.424954 — microbiology — Posted on 2021-07-07
3129 Fine-scale adaptations to environmental variation and growth strategies drive phyllosphere Methylobacterium diversity.
Leducq, J.-B.; Seyer-Lamontagne, E.; Condrain-Morel, D.; Bourret, G.; Sneddon, D.; Foster, J. A.; Marx, C. J.; Sullivan, J. M.; Shapiro, B. J.; Kembel, S. W.
10.1101/2021.06.04.447128 — microbiology — Posted on 2021-07-07
3130 Endosomal proteins NPC1 and NPC2 at African swine fever virus entry/fusion
Alonso, C.; Cuesta-Geijo, M. A.; Urquiza, J.; Del Puerto, A.; Garcia-Dorival, I.; Lasala, F.; Barrado-Gil, L.; Galindo, I.; Delgado, R.
10.1101/2021.07.07.451424 — microbiology — Posted on 2021-07-07
3133 Life on leaves : uncovering temporal dynamics in Arabidopsis' leaf microbiota
Almario, J.; Mahmoudi, M.; Kroll, S.; Agler, M.; Placzek, A.; Mari, A.; Kemen, E.
10.1101/2021.07.06.450897 — microbiology — Posted on 2021-07-08
3136 Human fetal neural stem cell-derived astrocytes maintain glutamate transport after hypoxic injury in vitro
Shrivastava, V.; Dey, D.; Singal, C. M. S.; Jaiswal, P.; Singh, A.; Sharma, J. B.; Chattopadhyay, P.; Palanichamy, J. K.; Sinha, S.; Seth, P.; Sen, S.
10.1101/2021.05.17.444180 — neuroscience — Posted on 2021-07-07
3137 Intrinsic Network Activity Reflects the Fluctuating Experience of Tonic Pain
Deak, B.; Eggert, T.; Mayr, A.; Stankewitz, A.; Filippopulos, F.; Jahn, P.; Witkovsky, V.; Straube, A.; Schulz, E.
10.1101/2021.06.30.450591 — neuroscience — Posted on 2021-07-07
3139 Single-cell profiling of the human primary motor cortex in ALS and FTLD
Pineda, S. S.; Lee, H.; Fitzwalter, B. E.; Mohammadi, S.; Pregent, L. J.; Gardashli, M. E.; Mantero, J.; Engelberg-Cook, E.; DeJesus-Hernandez, M.; van Blitterswijk, M.; Pottier, C.; Rademakers, R.; Oskarsson, B.; Shah, J. S.; Petersen, R. C.; Graff-Radford, N. R.; Boeve, B. F.; Knopman, D. S.; Josephs, K. A.; DeTure, M.; Murray, M. E.; Dickson, D. W.; Heiman, M.; Belzil, V. V.; Kellis, M.
10.1101/2021.07.07.451374 — neuroscience — Posted on 2021-07-07
3142 Two evolutionary distinct effectors from a nematode and virus target RanGAP1 and 2 via the WPP domain to promote disease
Sukarta, O. C. A.; Munoz, A. D. G.; Slootweg, E. J.; Overmars, H.; van Schaik, C.; Pokhare, S.; Roosien, J.; Pomp, R.; Elashry, A.; Smant, G.; Goverse, A.
10.1101/2021.06.24.449730 — plant biology — Posted on 2021-07-07
3143 A robust field-based method to screen heat tolerance in wheat
Ullah, N.; Christopher, J.; Frederiks, T.; Ma, S.; Tan, D.; Chenu, K.
10.1101/2021.06.09.447803 — plant biology — Posted on 2021-07-07
3144 ABA homeostasis and long-distance translocation is redundantly regulated by ABCG ABA importers
Zhang, Y.; Vasuki, H.; Liu, J.; Bar, H.; Lazary, S.; Egbaria, A.; Ripper, D.; Charrier, L.; Aharoni, A.; Ragni, L.; Strader, L.; Sade, N.; Weinstain, R.; Geisler, M.; Shani, E.
10.1101/2021.05.12.443788 — plant biology — Posted on 2021-07-07
3145 Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors
Foster, J. B.; Griffin, C.; Rokita, J. L.; Stern, A.; Brimley, C.; Rathi, K.; Lane, M. V.; Buongervino, S. N.; Smith, T.; Martinez, D.; Wechsler-Reya, R.; Kariko, K.; Storm, P. B.; Barrett, D. M.; Resnick, A. C.; Maris, J. M.; Bosse, K. R.
10.1101/2021.07.06.451385 — cancer biology — Posted on 2021-07-07
3146 Oncogenic RABL6A promotes NF1-associated MPNST progression in vivo
Kohlmeyer, J. L.; Kaemmer, C. A.; Lingo, J. J.; Leidinger, M. R.; Meyerholz, D. K.; Tanas, M. R.; Dodd, R. D.; Quelle, D. E.
10.1101/2021.07.07.451475 — cancer biology — Posted on 2021-07-07
3149 Genome-wide Disease Screening in Early Human Embryos with Primary Template-Directed Amplification
Xia, Y.; Gonzales-Pena, V.; Klein, D.; Luquette, J.; Puzon, L.; Siddiqui, N.; Reddy, V.; Park, P.; Behr, B.; Gawad, C.
10.1101/2021.07.06.451077 — bioengineering — Posted on 2021-07-07
3151 Interactome analyses reveal profound proteasome structural and functional rearrangements throughout mammalian spermatogenesis
Zivkovic, D.; Sanchez Dafun, A.; Menneteau, T.; Schahl, A.; Lise, S.; Kervarrec, C.; Toste-Rego, A.; da Fonseca, P.; Chavent, M.; Pineau, C.; Schiltz, O.; Marcoux, J.; Bousquet, M.-P.
10.1101/2021.06.18.447862 — biochemistry — Posted on 2021-07-07
3156 Concerted dynamics between conserved histidines in the N-extein region regulates Mycobacterium tuberculosis SufB intein cleavage
Panda, S.; Nanda, A.; Sahu, N.; Ojha, D. K.; Pradhan, B.; Rai, A.; Suryawanshi, A. R.; Banavali, N.; Nayak, S.
10.1101/2021.07.07.451452 — molecular biology — Posted on 2021-07-07
3157 High-throughput functional analysis of CFTR and other apically localized channels in iPSC derived intestinal organoids
Xia, S.; Bozoky, Z.; Laselva, O.; DiPaola, M.; Ahmadi, S.; Jiang, J. X.; Pitstick, A.; Jiang, C.; Rotin, D.; Mayhew, C.; Jones, N. L.; Bear, C. E.
10.1101/2021.07.07.451180 — molecular biology — Posted on 2021-07-07
3158 UPF3A and UPF3B are redundant and modular activators of nonsense-mediated mRNA decay in human cells
Wallmeroth, D.; Boehm, V.; Lackmann, J.-W.; Altmueller, J.; Dieterich, C.; Gehring, N. H.
10.1101/2021.07.07.451444 — molecular biology — Posted on 2021-07-07
3160 SAFA facilitates chromatin opening of immune genes through interacting with nascent antiviral RNAs
Cao, L.; Li, Y.; Luo, Y.; Guo, X.; Li, S.; Zhang, Z.; Gao, F.; Zhang, Q.; Ji, X.; Gao, X.; Wang, Y.; Zhao, Y.; You, F.; Liu, S.; Li, J.
10.1101/2021.07.06.451336 — immunology — Posted on 2021-07-07
3161 Clostridium difficile Toxin B activates the NLRP3 inflammasome in human macrophages, demonstrating a novel regulatory mechanism for the Pyrin inflammasome
Mangan, M. S. J.; Gorki, F.; Krause, K.; Heinz, A.; Ebert, T.; Jahn, D.; Hiller, K.; Hornung, V.; Mauer, M.; Schmidt, F. I.; Gerhard, R.; Latz, E.
10.1101/2021.07.07.451422 — immunology — Posted on 2021-07-07
3162 Adult medial habenula neurons require GDNF receptor GFRalpha1 for synaptic stability and function
Fernandez-Suarez, D.; Krapacher, F.; Pietrajtis, K.; Andersson, A.; Kisiswa, L.; Diana, M.; Ibanez, C.
10.1101/2021.07.07.451421 — neuroscience — Posted on 2021-07-07
3163 Chronic CNS Pathology is Associated with Abnormal Collagen Deposition and Fibrotic-like Changes
Macapagal, D.; Cann, J.; Zerrouki, K.; Dacosta, K.; Wang, J.; Connor, J.; Cresswell, G.; Davidson, T.
10.1101/2021.07.06.451298 — neuroscience — Posted on 2021-07-07
3164 A unified theory of E/I synaptic balance, quasicritical neuronal avalanches and asynchronous irregular spiking
Girardi-Schappo, M.; Galera, E. F.; Carvalho, T. T. A.; Brochini, L.; Kamiji, N. L.; Roque, A. C.; Kinouchi, O.
10.1101/2020.12.17.423201 — neuroscience — Posted on 2021-07-07
3165 Multivalent designed proteins protect against SARS-CoV-2 variants of concern
Hunt, A. C.; Case, J. B.; Park, Y.-J.; Cao, L.; Wu, K.; Walls, A. C.; Liu, Z.; Bowen, J. E.; Yeh, H.-W.; Saini, S.; Helms, L.; Zhao, Y. T.; Hsiang, T.-Y.; Starr, T. N.; Goreshnik, I.; Kozodoy, L.; Carter, L.; Ravichandran, R.; Green, L. B.; Matochko, W. L.; Thomson, C. A.; Vogeli, B.; Kruger-Gericke, A.; VanBlargan, L. A.; Chen, R. E.; Ying, B.; Bailey, A. L.; Kafai, N. M.; Boyken, S.; Ljubetic, A.; Edman, N.; Ueda, G.; Chow, C.; Addetia, A.; Panpradist, N.; Gale, M.; Freedman, B.; Lutz, B.; Bloom, J. D.; Ruohola-Baker, H.; Whelan, S. P. J.; Stewart, L.; Diamond, M. S.; Veesler, D.; Jewett, M.
10.1101/2021.07.07.451375 — synthetic biology — Posted on 2021-07-07
3166 Synthetic genomic reconstitution reveals principles of mammalian Hox cluster regulation
Pinglay, S.; Bulajic, M.; Rahe, D. P.; Huang, E.; Brosh, R.; German, S.; Cadley, J. A.; Rieber, L.; Easo, N.; Mahony, S.; Maurano, M. T.; Holt, L. J.; Mazzoni, E. O.; Boeke, J. D.
10.1101/2021.07.07.451065 — synthetic biology — Posted on 2021-07-07
3168 Optimization of the TeraTox assay for preclinical teratogenicity assessment
Jaklin, M.; Zhang, J. D.; Schaefer, N.; Clemann, N.; Barrow, P.; Kueng, E.; Sach-Peltason, L.; McGinnis, C.; Leist, M.; Kustermann, S.
10.1101/2021.07.06.451364 — pharmacology and toxicology — Posted on 2021-07-07
3169 Re-convolving the compositional landscape of primary and recurrent glioblastoma using single nucleus RNA sequencing
Al-Dalahmah, O.; Argenziano, M.; Boyett, D.; Save, A.; Mahajan, A.; Khan, F.; Tuddenham, J.; goldberg, a. r.; Dovas, A.; Banu, M.; Furnari, J.; Sudhakar, T.; Bush, E.; Lassman, A.; Bruce, J.; Sims, P.; Menon, V.; Canoll, P.
10.1101/2021.07.06.451295 — pathology — Posted on 2021-07-07
3170 m6A demethylase ALKBH5 promotes tumor cell proliferation by destabilizing IGF2BPs target genes and worsens the prognosis of patients with non-small cell lung cancer
Tsuchiya, K.; Yoshimura, K.; Iwashita, Y.; Inoue, Y.; Ohta, T.; Watanabe, H.; Yamada, H.; Kawase, A.; Tanahashi, M.; Ogawa, H.; Funai, K.; Shinmura, K.; Suda, T.; Sugimura, H.
10.1101/2021.07.06.451216 — cancer biology — Posted on 2021-07-07
3172 CAT, AGTR2, L-SIGN and DC-SIGN are potential receptors for the entry of SARS-CoV-2 into human cells
Guo, D.; Guo, R.; Li, Z.; Zhang, Y.; Zheng, W.; Huang, X.; Aziz, T.; Zhang, Y.; Liu, L.
10.1101/2021.07.07.451411 — bioinformatics — Posted on 2021-07-07
3173 Wireless endovascular nerve stimulation with a millimeter-sized magnetoelectric implant
Chen, J. C.; Kan, P.; Yu, Z.; Alrashdan, F.; Garcia, R.; Singer, A. C.; Lai, C. S. E.; Avants, B.; Crosby, S.; Felicella, M. M.; Robledo, A.; Hartgerink, J. D.; Sheth, S. A.; Yang, K.; Robinson, J. T.
10.1101/2021.07.06.450036 — bioengineering — Posted on 2021-07-07
3174 Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling
Mohapatra, J.; Tashiro, K.; Beckner, R. L.; Sierra, J.; Kilgore, J. A.; Williams, N. S.; Liszczak, G.
10.1101/2021.07.06.449314 — biochemistry — Posted on 2021-07-07
3176 The E. coli helicase does not use ATP during replication.
Spenkelink, L. M.; Spinks, R. R.; Jergic, S.; Lewis, J. S.; Dixon, N. E.; van Oijen, A. M.
10.1101/2021.07.07.451541 — biochemistry — Posted on 2021-07-07
3178 Microchromosomes are building blocks of bird, reptile and mammal chromosomes
Waters, P. D.; Patel, H. R.; Ruiz-Herrera, A.; Alvarez-Gonzalez, L.; Lister, N. C.; Simakov, O.; Ezaz, T.; Kaur, P.; Frere, C.; Grutzner, F.; Georges, A.; Graves, J. A. M.
10.1101/2021.07.06.451394 — genomics — Posted on 2021-07-07
3179 Receptor-binding domain recombinant protein RBD219-N1C1 on alum-CpG induces broad protection against SARS-CoV-2 variants of concern
Pollet, J.; Strych, U.; Chen, W.-H.; Versteeg, L.; Keegan, B.; Zhan, B.; Wei, J.; Liu, Z.; Lee, J.; Kundu, R.; Adhikari, R.; Poveda, C.; Villar, M. J.; Lopez, B.; Gillespie, P. M.; Ronca, S.; Kimata, J. T.; Reers, M.; Paradkar, V.; Hotez, P.; Bottazzi, M. E.
10.1101/2021.07.06.451353 — molecular biology — Posted on 2021-07-07
3181 Immunogenicity of low dose prime-boost vaccination of mRNA vaccine CV07050101 in non-human primates
van Doremalen, N.; Fischer, R.; Schulz, J.; Holbrook, M.; Smith, B.; Lovaglio, J.; Petsch, B.; Munster, V.
10.1101/2021.07.07.451505 — microbiology — Posted on 2021-07-07
3182 Genome-wide association study reveals putative bacterial risk factors for cavitary Mycobacterium avium complex lung disease
Yano, H.; Nishiuchi, Y.; Arikawa, K.; Ota, A.; Miki, M.; Maruyama, F.; Kida, H.; Kitada, S.; Iwamoto, T.
10.1101/2021.07.06.451401 — microbiology — Posted on 2021-07-07
3184 Defining the Immune Responses for SARS-CoV-2-Human Macrophage Interactions
Mostafa, M.; Yeapuri, P.; Machhi, J.; Olson, K.; Shahjin, F.; Zhou, Y.; Jingjing, L.; Pandey, K.; Acharya, A.; Byrareddy, S.; Mosley, L.; Gendelman, H.
10.1101/2021.07.07.449660 — immunology — Posted on 2021-07-07
3186 The methamphetamine-induced RNA targetome of hnRNP H in Hnrnph1 mutants showing reduced dopamine release and behavior
Ruan, Q. T.; Rieger, M. A.; Lynch, W. B.; Cox, J. W.; Beierle, J. A.; Yao, E. J.; Kandola, A.; Chen, M. M.; Kelliher, J. C.; Babbs, R. K.; Ash, P. E. A.; Wolozin, B.; Szumlinski, K. K.; Johnson, W. E.; Dougherty, J.; Bryant, C. D.
10.1101/2021.07.06.451358 — neuroscience — Posted on 2021-07-07
3188 Multi-modal locomotor costs explain sexual size but not shape dimorphism in a leaf-mimicking insect
Boisseau, R. P.; Buscher, T. H.; Klawitter, L. J.; Gorb, S. N.; Emlen, D. J.; Tobalske, B. W.
10.1101/2021.07.06.451325 — ecology — Posted on 2021-07-07
3189 Biomechanical study of cellulose scaffolds for bone tissue engineering in vivo and in vitro.
Leblanc Latour, M.; Tarar, M.; Hickey, R. J.; Cuerrier, C. M.; Catelas, I.; Pelling, A.
10.1101/2021.07.07.451476 — bioengineering — Posted on 2021-07-07
3190 Epigenetic scores for the circulating proteome as tools for disease prediction
Gadd, D. A.; Hillary, R. F.; McCartney, D. L.; Zaghlool, S. B.; Stevenson, A. J.; Nangle, C.; Campbell, A.; Flaig, R.; Harris, S. E.; Walker, R. M.; Shi, L.; Tucker-Drob, E. M.; Gieger, C.; Peters, A.; Waldenberger, M.; Graumann, J.; McRae, A. F.; Deary, I. J.; Porteous, D. J.; Hayward, C.; Visscher, P. M.; Cox, S. R.; Evans, K. L.; McIntosh, A. M.; Suhre, K.; Marioni, R. E.
10.1101/2020.12.01.404681 — genomics — Posted on 2021-07-07
3191 Molecular adaptation to folivory and the conservation implications for Madagascar's lemurs
Guevara, E. E.; Greene, L. K.; Blanco, M. B.; Farmer, C.; Ranaivonasy, J.; Ratsirarson, J.; Mahefarisoa, K.; Rajaonarivelo, T.; Rakotondrainibe, H.; Junge, R.; Williams, C.; Rambeloson, E.; Rasoanaivo, H.; Rahalinarivo, V.; Andrianandrianina, L.; Clayton, J.; Rothman, R.; Lawler, R. R.; Bradley, B. J.; Yoder, A. D.
10.1101/2021.07.06.451309 — ecology — Posted on 2021-07-07
3193 S18-phosphorylation of USP7 regulates interaction with TCEAL4 that defines specific complexes and potentially distinct functions.
Querques, F.; Darling, S.; Cheetham-Wilkinson, I.; Kim, R.; Hapangama, D. K.; Sixma, T. K.; Coulson, J. M.
10.1101/2021.07.07.451439 — cell biology — Posted on 2021-07-07
3194 Myeloid-to-mesenchymal NGF-p75 signaling coordinates skeletal cell migration during repair
Xu, J.; Li, Z.; Tower, R. J.; Negri, S.; Wang, Y.; Meyers, C. A.; Sono, T.; Qin, Q.; Lu, A.; McCarthy, E. F.; Clemens, T. L.; James, A. W.
10.1101/2021.07.07.451468 — cell biology — Posted on 2021-07-07
3196 Distinct mitochondrial remodeling during early cardiomyocyte development in a human-based stem cell model
Mostafavi, S.; Balafkan, N.; Pettersen, I. K. N.; Nido, G. S.; Siller, R.; Tzoulis, C.; Sullivan, G.; Bindoff, L. A.
10.1101/2021.07.07.451436 — cell biology — Posted on 2021-07-07
3197 Nucleolar NOC1 controls protein synthesis and cell competition in Drosophila
Destefanis, F.; Manara, V.; Santarelli, S.; Zola, S.; Brambilla, M.; Viola, G.; Maragno, P.; Viero, G.; Pasini, M. E.; Penzo, M.; Bellosta, P.
10.1101/2021.07.06.451100 — cell biology — Posted on 2021-07-07
3198 Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine
Cao, J.; Li, M.; Liu, K.; Shi, X.; Sui, N.; Yao, Y.; Wang, X.; Tan, S.; Zhao, Q.; Wang, L.; Chai, X.; Zhang, L.; Liu, C.; Li, X.; Chang, Z.; Li, D.; Zhao, T.
10.1101/2021.07.06.451381 — cell biology — Posted on 2021-07-07
3199 Dynamics in Fip1 regulate eukaryotic mRNA 3'-end processing
Kumar, A.; Yu, C. W.; Rodriguez-Molina, J. B.; Li, X.-H.; Freund, S. M.; Passmore, L. A.
10.1101/2021.07.07.451483 — molecular biology — Posted on 2021-07-07
3200 Spontaneous pauses in firing of external pallidum neurons are associated with exploratory behavior
Kaplan, A.; Mizrahi-Kliger, A. D.; Rappel, P.; Iskhakova, L.; Fonar, G.; Israel, Z.; Bergman, H.
10.1101/2021.07.06.451269 — neuroscience — Posted on 2021-07-07
3202 Mapping circuit dynamics during function and dysfunction
Gorur-Shandilya, S.; Cronin, E. M.; Schneider, A. C.; Haddad, S. A.; Rosenbaum, P.; Bucher, D.; Nadim, F.; Marder, E.
10.1101/2021.07.06.451370 — neuroscience — Posted on 2021-07-07
3203 Simvastatin Therapy Attenuates Memory Deficits that Associate with Brain Monocyte Infiltration in Chronic Hypercholesterolemia
Don-Doncow, N.; Vanherle, L.; Matthes, F.; Kragh Petersen, S.; Matuskova, H.; Rattik, S.; Hartlova, A.; Meissner, A.
10.1101/2020.05.15.098236 — physiology — Posted on 2021-07-07
3206 Force generation by protein-DNA co-condensation
Quail, T.; Golfier, S.; Elsner, M.; Ishihara, K.; Renger, R.; Julicher, F.; Brugues, J.
10.1101/2020.09.17.302299 — biophysics — Posted on 2021-07-07
3210 MONI: A Pangenomics Index for Finding MEMs
Rossi, M.; Oliva, M.; Langmead, B.; Gagie, T.; Boucher, C.
10.1101/2021.07.06.451246 — bioinformatics — Posted on 2021-07-07
3211 DyNeuMo Mk-1: Design and Pilot Validation of an Investigational Motion-Adaptive Neurostimulator with Integrated Chronotherapy
Zamora, M.; Toth, R.; Morgante, F.; Ottaway, J.; Gillbe, T.; Martin, S.; Lamb, G.; Noone, T.; Benjaber, M.; Nairac, Z.; Constandinou, T. G.; Herron, J.; Aziz, T. Z.; Gillbe, I.; Green, A. L.; Pereira, E.; Denison, T.
10.1101/2020.09.10.292284 — bioengineering — Posted on 2021-07-07
3212 Proteolytic Activation of Human-specific Olduvai Domains by the Furin Protease
Pacheco, A.; Issaian, A.; Davis, J.; Anderson, N.; Nemkov, T.; Vögeli, B.; Hansen, K.; Sikela, J.
10.1101/2021.07.06.450945 — evolutionary biology — Posted on 2021-07-07
3213 Predictability and parallelism in the contemporary evolution of hybrid genomes
Langdon, Q. K.; Powell, D. L.; Kim, B.; Banerjee, S. M.; Payne, C.; Dodge, T. O.; Moran, B.; Fascinetto-Zago, P.; Schumer, M.
10.1101/2021.07.06.451368 — evolutionary biology — Posted on 2021-07-07
3217 Ultrastructural readout of in vivo synaptic activity for functional connectomics.
Simon, A.; Roth, A.; Sheridan, A.; Fisek, M.; Marra, V.; Racca, C.; Funke, J.; Staras, K.; Hausser, M.
10.1101/2021.07.07.451278 — neuroscience — Posted on 2021-07-07
3219 History of winning and hierarchy landscape influence stress susceptibility in mice
LeClair, K. B.; Chan, K. L.; Kaster, M. P.; Parise, L. F.; Burnett, C. J.; Russo, S.
10.1101/2021.07.06.451249 — neuroscience — Posted on 2021-07-07
3224 Behavioral, Anatomical and Genetic Convergence of Affect and Cognition in Superior Frontal Cortex
Kraljevic, N.; Schaare, H. L.; Eickhoff, S. B.; Kochunov, P.; Yeo, B. T. T.; Kharabian Masouleh, S.; Valk, S. L.
10.1101/2020.12.03.401414 — neuroscience — Posted on 2021-07-07
3226 Recovering Escherichia coli plasmids in the absence of long-read sequencing data
Paganini, J. A.; Plantinga, N. L.; Arredondo-Alonso, S.; Willems, R. J. L.; Schurch, A. C.
10.1101/2021.07.06.451259 — bioinformatics — Posted on 2021-07-07
3230 The orexigenic force of olfactory palatable food cues in sated rats
Peris-Sampedro, F.; Stoltenborg, I.; Le May, M. V.; Sole-Navais, P.; Adan, R. A.; Dickson, S. L.
10.1101/2021.07.06.451251 — neuroscience — Posted on 2021-07-07
3233 DiMeLo-seq: a long-read, single-molecule method for mappingprotein-DNA interactions genome-wide
Altemose, N.; Maslan, A.; Smith, O. K.; Sundararajan, K.; Brown, R. R.; Detweiler, A. M.; Neff, N.; Miga, K. H.; Straight, A. F.; Streets, A.
10.1101/2021.07.06.451383 — genomics — Posted on 2021-07-07
3235 Adaptive foraging behaviour increases vulnerability to climate change
Gauzens, B.; Rosenbaum, B.; Kalinkat, G.; Boy, T.; Jochum, M.; Kortsch, S.; O'Gorman, E. J.; Brose, U.
10.1101/2021.05.05.442768 — ecology — Posted on 2021-07-07
3236 Heat-treated virus inactivation rate depends strongly on treatment procedure: illustration with SARS-CoV-2
Gamble, A.; Fischer, R. J.; Morris, D. H.; Yinda, K. C.; Munster, V. J.; Lloyd-Smith, J. O.
10.1101/2020.08.10.242206 — microbiology — Posted on 2021-07-07
3237 Spike frequency adaptation supports network computations on temporally dispersed information
Salaj, D.; Subramoney, A.; Kraisnikovic, C.; Bellec, G.; Legenstein, R.; Maass, W.
10.1101/2020.05.11.081513 — neuroscience — Posted on 2021-07-07
3241 Entering into a self-regulated learning mode prevents detrimental effect of feedback removal on memory
Vavra, P.; Sokolovic, L.; Porcu, E.; Ripolles, P.; Rodriguez-Fornells, A.; Noesselt, T.
10.1101/2021.07.02.450865 — neuroscience — Posted on 2021-07-07
3245 Genomes of novel Myxococcota reveal severely curtailed machineries for predation and cellular differentiation
Murphy, C.; Cavalliere, C.; Cornell, J.; Higgs, J.; Mares, S.; Meili, C.; Andreev, V.; Bircher, N.; Decker, T.; Dohmen, R.; Eichhorn, A.; Grinnell, A.; Jett, C.; Khadka, R.; Liu, J.; Mukhtar, H.; Pratt, C.; Elshahed, M. S.; Youssef, N. H.
10.1101/2021.07.06.451402 — microbiology — Posted on 2021-07-07
3248 Genome Profiling of SARS-CoV-2 in Indonesia, ASEAN and the Neighbouring East Asian Countries: Features, Challenges and Achievements
Cahyani, I.; Putro, E. W.; Ridwanuloh, A. M.; Wibowo, S.; Hariyatun, ; Syahputra, G.; Akbariani, G.; Utomo, A. R.; Ilyas, M.; Loose, M. W.; Kusharyoto, W.; Susanti, S.
10.1101/2021.07.06.451270 — genomics — Posted on 2021-07-07
3250 Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection
Wang, R.; Hume, A.; Beermann, M. L.; Simone-Roach, C.; Lindstrom-Vautrin, J.; Le Suer, J.; Huang, J.; Olejnik, J.; Villacorta-Martin, C.; Bullitt, E.; Hinds, A.; Ghaedi, M.; Werder, R.; Abo, K.; Wilson, A.; Muhlberger, E.; Kotton, D. N.; Hawkins, F. J.
10.1101/2021.07.06.451340 — cell biology — Posted on 2021-07-07
3257 A Newcastle disease virus-vector expressing a prefusion-stabilized spike protein of SARS-CoV-2 induces protective immune responses against prototype virus and variants of concern in mice and hamsters
Sun, W.; Liu, Y.; Amanat, F.; Gonzalez-Dominguez, I.; McCroskery, S.; Slamanig, S.; Coughlan, L.; Rosado, V.; Lemus, N.; Jangra, S.; Rathnasinghe, R.; Schotsaert, M.; Martinez, J.; Sano, K.; Mena, I.; Innis, B. L.; Wirachwong, P.; Thai, D. H.; Oliveira, R. D. N.; Scharf, R.; Hjorth, R.; Raghunandan, R.; Krammer, F.; Garcia-Sastre, A.; Palese, P.
10.1101/2021.07.06.451301 — immunology — Posted on 2021-07-07
3258 Nonclinical Safety and Immunogenicity of an rVSV-ΔG-SARS-CoV-2-S vaccine in mice, hamsters, rabbits and pigs
Madar-Balakirski, N.; Rosner, A.; Melamed, S.; Politi, B.; Steiner, M.; Tamir, H.; Yahalom Ronen, Y.; Bar-David, E.; Ben-Shmuel, A.; Sittner, A.; Glinert, I.; Weiss, S.; Bar-Haim, E.; Cohen, H.; Elia, U.; Achdout, H.; Erez, N.; Rotem, S.; Lazar, S.; Nyska, A.; Yitzhaki, S.; Beth-Din, A.; Levy, H.; Paran, N.; Israely, T.; Marcus, H.
10.1101/2021.07.06.451119 — pharmacology and toxicology — Posted on 2021-07-07
3262 Mouse Antibodies with Activity Against the SARS-CoV-2 D614G and B.1.351 Variants
Troitskaya, L.; Chan, N. L. S.; Frank, B.; Capon, D.; Zabel, B. A.; Ge, X.; Luo, D.; Martinelli, R.; Jin, J.; Simmons, G.
10.1101/2021.07.05.451203 — molecular biology — Posted on 2021-07-07
3264 Micronutrient supplements with iron promote disruptive protozoan and fungal communities in the developing infant gut
Popovic, A.; Bourdon, C.; Wang, P. W.; Guttman, D. S.; Soofi, S.; Bhutta, Z. A.; Bandsma, R. H. J.; Parkinson, J.; Pell, L. G.
10.1101/2021.07.06.451346 — microbiology — Posted on 2021-07-06
3266 Zeb2 DNA-binding sites in ES cell derived neuroprogenitor cells reveal autoregulation and align with neurodevelopmental knockout mouse and disease phenotypes.
Birkhoff, J. C.; Korporaal, A. L.; Brouwer, R. W. W.; Milazzo, C.; Mouratidou, L.; van den Hout, M. C. G. N.; van IJcken, W. F. J.; Huylebroeck, D.; Conidi, A.
10.1101/2021.07.06.451350 — cell biology — Posted on 2021-07-06
3267 Multiparametric profiling of cellular lipid metabolism in hypercholesterolemia
Pfisterer, S. G.; Brock, I.; Kanerva, K.; Hlushchenko, I.; Paavolainen, L.; Ripatti, P.; Islam, M. M.; Kyttala, A.; Di Taranto, M. D.; di Frega, A. S.; Fortunato, G.; Kuusisto, J.; Horvath, P.; Ripatti, S.; Laakso, M.; Ikonen, E.
10.1101/2021.04.19.440471 — cell biology — Posted on 2021-07-06
3270 Outer membrane vesicles derived from Klebsiella pneumoniae are a driving force for horizontal gene transfer
Dell'Annunziata, F.; DellAversana, C.; Doti, N.; Donadio, G.; Dal Piaz, F.; Izzo, V.; De Filippis, A.; Galdiero, M.; Altucci, L.; Boccia, G.; Galdiero, M.; Folliero, V.; Franci, G.
10.1101/2021.07.06.451238 — microbiology — Posted on 2021-07-06
3271 Social experience alters oxytocinergic modulation in the nucleus accumbens of female prairie voles
Borie, A. M.; Agezo, S.; Lunsford, P.; Boender, A. J.; Guo, J.-D.; Zhu, H.; Berman, G. J.; Young, L. J.; Liu, R. C.
10.1101/2021.07.06.451323 — neuroscience — Posted on 2021-07-06
3275 Selection-Enriched Genomic Loci (SEGL) Reveals Genetic Loci for Environmental Adaptation and Photosynthetic Productivity in Chlamydomonas reinhardtii.
Lucker, B. F.; Panchy, N.; Temple, J.; Benning, U.; Bibik, J.; Neofotis, P.; Weissman, J.; Baxter, I.; Shu, S.-H.; Kramer, D.
10.1101/2021.07.06.451237 — evolutionary biology — Posted on 2021-07-06
3277 PECAn, a pipeline for image processing and statistical analysis of complex mosaic 3D tissues
Baumgartner, M. E.; Langton, P. F.; Mastrogiannopoulos, A.; Logeay, R.; Piddini, E.
10.1101/2021.07.06.451317 — cell biology — Posted on 2021-07-06
3278 Interrogation of genome-wide, experimentally dissected gene regulatory networks reveals mechanisms underlying dynamic cellular state control
Tan, X.; Worley, J.; Turunen, M.; Wong, K.; Fernandez, E. C.; Paull, E.; Jones, S.; Wang, J.; Noh, H.; Salvatori, B.; Chavez, A.; Califano, A.
10.1101/2021.06.28.449297 — systems biology — Posted on 2021-07-06
3279 Identification of genetic markers and wood properties that predict wood biorefinery potential in aspen bioenergy feedstock (Populus tremula).
Escamez, S.; Luomaranta, M.; Mahler, N.; Gandla, M. L.; Robinson, K. M.; Yassin, Z.; Grahn, T.; Scheepers, G.; Stener, L.-G.; Jonsson, L. J.; Jansson, S.; Street, N.; Tuominen, H.
10.1101/2021.07.06.450716 — plant biology — Posted on 2021-07-06
3283 Global evolutionary dynamics and resistome analysis of Clostridioides difficile ribotype 017
Imwattana, K.; Putsathit, P.; Collins, D. A.; Leepattarakit, T.; Kiratisin, P.; Riley, T. V.; Knight, D. R.
10.1101/2021.07.04.451084 — microbiology — Posted on 2021-07-06
3284 Activity dependent translation in astrocytes dynamically alters the proteome of the perisynaptic astrocyte process
Sapkota, D.; Kater, M. S. J.; Sakers, K.; Nygaard, K. R.; Liu, Y.; Lake, A. M.; Khazanchi, R.; Khankan, R. R.; Smit, A. B.; Maloney, S. E.; Verheijen, M. H. G.; Zhang, Y.; Dougherty, J. D.
10.1101/2020.04.08.033027 — neuroscience — Posted on 2021-07-06
3286 Injury-Free In Vivo Delivery and Engraftment into the Cornea Endothelium Using Extracellular Matrix Shrink-Wrapped Cells
Palchesko, R. N.; Du, Y.; Geary, M.; Carrasquilla, S.; Shiwarski, D. J.; Khandaker, I.; Feunderburgh, J. L.; Feinberg, A. W.
10.1101/2021.03.01.433476 — bioengineering — Posted on 2021-07-06
3287 Neural ADMIXTURE: rapid population clustering with autoencoders
Mantes, A. D.; Montserrat, D. M.; Bustamante, C.; Giro-i-Nieto, X.; Ioannidis, A. G.
10.1101/2021.06.27.450081 — genomics — Posted on 2021-07-06
3290 Polygenic routes lead to parallel altitudinal adaptation in Heliosperma pusillum (Caryophyllaceae)
Szukala, A.; Lovegrove-Walsh, J.; Luqman, H.; Fior, S.; Wolfe, T. M.; Frajman, B.; Schoenswetter, P.; Paun, O.
10.1101/2021.07.05.451094 — evolutionary biology — Posted on 2021-07-06
3291 Cumulative growth and stress responses to the 2018-2019 drought in a European floodplain forest
Schnabel, F.; Purrucker, S.; Schmitt, L.; Engelmann, R. A.; Kahl, A.; Richter, R.; Seele-Dilbat, C.; Skiadaresis, G.; Wirth, C.
10.1101/2021.03.05.434090 — ecology — Posted on 2021-07-06
3293 The total mRNA concentration buffering system in yeast is global rather than gene-specific
Garcia-Martinez, J.; Medina, D. A.; Bellvis, P.; Sun, M.; Cramer, P.; Chavez, S.; Perez-Ortin, J. E.
10.1101/2021.01.14.426689 — molecular biology — Posted on 2021-07-06
3295 Region-specific, maladaptive, gray matter myelination is associated with differential susceptibility to stress-induced behavior in rats and humans
Long, K. L. P.; Chao, L. L.; Kazama, Y.; An, A.; Hu, K. Y.; Peretz, L.; Muller, D. C. Y.; Roan, V. D.; Misra, R.; Toth, C. E.; Breton, J. M.; Casazza, W.; Mostafavi, S. M.; Huber, B. R.; Woodward, S. H.; Neylan, T. C.; Kaufer, D.
10.1101/2021.02.15.431176 — neuroscience — Posted on 2021-07-06
3299 A computational model for investigating the evolution of colonic crypts during Lynch syndrome carcinogenesis
Haupt, S.; Gleim, N.; Ahadova, A.; Bläker, H.; von Knebel Doeberitz, M.; Kloor, M.; Heuveline, V.
10.1101/2020.12.29.424555 — cancer biology — Posted on 2021-07-06
3303 homeRNA: A self-sampling kit for the collection of peripheral blood and stabilization of RNA
Haack, A. J.; Lim, F. Y.; Kennedy, D. S.; Day, J. H.; Adams, K. N.; Lee, J. J.; Berthier, E.; Theberge, A. B.
10.1101/2021.02.08.430337 — bioengineering — Posted on 2021-07-06
3307 Quantitative intracellular retention of delivered RNAs through optimized cell fixation and immuno-staining
Paramasivam, P.; Stoter, M.; Corradi, E.; Costa, I. D.; Hoijer, A.; Bartesaghi, S.; Sabirsh, A.; Lindfors, L.; Arteta, M. Y.; Nordberg, P.; Andersson, S.; Baudet, M.-L.; Bickle, M.; Zerial, M.
10.1101/2021.07.06.451306 — cell biology — Posted on 2021-07-06
3308 Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex
Koike, Y.; Sugai, A.; Hara, N.; Ito, J.; Yokoseki, A.; Ishihara, T.; Yamagishi, T.; Tsuboguchi, S.; Tada, M.; Ikeuchi, T.; Kakita, A.; Onodera, O.
10.1101/2021.01.13.426599 — molecular biology — Posted on 2021-07-06
3309 Pulling the strings of cell cycle: a non-coding RNA, CcnA, modulates the master regulators CtrA and GcrA in Caulobacter crescentus
Beroual, W.; Lalaouna, D.; Benzaina, N.; Valette, O.; Prevost, K.; Denis, Y.; Djendli, M.; Brasseur, G.; Brilli, M.; Robledo, M.; Jimenez Zurdo, J. I.; Masse, E.; Biondi, E. G.
10.1101/756452 — microbiology — Posted on 2021-07-06
3310 Cerebral laterality for writing in right- and left-handers: A functional transcranial Doppler ultrasound study
Papadatou-Pastou, M.; Sampanis, P.; Koumzis, I.; Stefanopoulou, S.; Sousani, D.; Tsigkou, A.; Badcock, N. A.
10.1101/2020.07.14.203588 — neuroscience — Posted on 2021-07-06
3312 CatSper mediates the chemotactic behavior and motility of the ascidian sperm
Kijima, T.; Kurokawa, D.; Sasakura, Y.; Ogasawara, M.; Aratake, S.; Yoshida, K.; Yoshida, M.
10.1101/2021.07.06.451356 — developmental biology — Posted on 2021-07-06
3315 SARS-CoV-2 Nsp14 mediates the effects of viral infection on the host cell transcriptome
Zaffagni, M.; Harris, J. M.; Patop, I. L.; Pamudurti, N. R.; Nguyen, S.; Kadener, S.
10.1101/2021.07.02.450964 — molecular biology — Posted on 2021-07-06
3317 Life on leaves : uncovering temporal dynamics in Arabidopsis' leaf microbiota
Almario, J.; Mahmoudi, M.; Kroll, S.; Agler, M.; Placzek, A.; Mari, A.; Kemen, E. T.
10.1101/2021.07.06.450897 — microbiology — Posted on 2021-07-06
3319 Dietary Exposure to Antibiotic Residues Facilitates Metabolic Disorder by Altering the Gut Microbiota and Bile Acid Composition
Chen, R.-A.; Wu, W.-K.; Panyod, S.; Liu, P.-Y.; Chuang, H.-L.; Chen, Y.-H.; Lyu, Q.; Hsu, H.-C.; Lin, T.-L.; Shen, T.-C. D.; Yang, Y.-T.; Zou, H.-B.; Huang, H.-S.; Lin, Y.-E.; Chen, C.-C.; Ho, C.-T.; Lai, H.-C.; Wu, M.-S.; Hsu, C.-C.; Sheen, L.-Y.
10.1101/2021.07.06.451284 — microbiology — Posted on 2021-07-06
3320 The fruit fly Anastrepha obliqua harbors three kingdoms of life in its intestinal tract.
Amores, G. R.; Zepeda-Ramos, G.; Garcia-Fajardo, L. V.; Hernandez, E.; Guillen-Navarro, K.
10.1101/2021.07.06.451314 — microbiology — Posted on 2021-07-06
3321 Ca2+-dependent liquid-liquid phase separation underlies intracellular Ca2+ stores.
Mayfield, J. E.; Pollak, A. J.; Worby, C. A.; Xu, J. C.; Tandon, V.; Newton, A. C.; Dixon, J. E.
10.1101/2021.07.06.451223 — biochemistry — Posted on 2021-07-06
3322 Structure of mycobacterial CIII2CIV2 respiratory supercomplex bound to the tuberculosis drug candidate telacebec (Q203)
Yanofsky, D. J.; Di Trani, J. M.; Krol, S.; Abdelaziz, R.; Bueler, S. A.; Imming, P.; Brzezinski, P.; Rubinstein, J. L.
10.1101/2021.07.06.451285 — biochemistry — Posted on 2021-07-06
3323 C2CD6 is required for assembly of the CatSper calcium channel complex and fertilization
Yang, F.; Gervasi, M. G.; Leu, N. A.; Tourzani, D. A.; Ruthel, G.; Visconti, P. E.; Wang, J.
10.1101/2021.07.06.451342 — developmental biology — Posted on 2021-07-06
3324 Downregulation of WT1 transcription factor gene expression is required to promote myocardial fate
Marques, I. J.; Ernst, A.; Arora, P.; Vianin, A.; Hetke, T.; Sanz-Morejon, A.; Naumann, U.; Odriozola, A.; Oliva, X. L.; Andres-Delgado, L.; Haberthuer, D.; Zuber, B.; Torroja, C.; Hlushchuk, R.; Osterwalder, M.; Simoes, F.; Englert, C.; Mercader, N.
10.1101/2021.07.06.451274 — developmental biology — Posted on 2021-07-06
3328 TAF8 regions important for TFIID lobe B assembly, or for TAF2 interactions, are required for embryonic stem cell survival
Scheer, E.; Luo, J.; Ruffenach, F.; Garnier, J.-M.; Kolb-Cheynel, I.; Gupta, K.; Berger, I.; Ranish, J.; Tora, L.
10.1101/2021.07.06.451281 — molecular biology — Posted on 2021-07-06
3332 MiDAS 4: A global catalogue of full-length 16S rRNA gene sequences and taxonomy for studies of bacterial communities in wastewater treatment plants
Dueholm, M. S.; Nierychlo, M.; Andersen, K. S.; Joergensen, V. R.; Knutsson, S.; the MiDAS Global Consortium, ; Albertsen, M.; Nielsen, P. H.
10.1101/2021.07.06.451231 — microbiology — Posted on 2021-07-06
3336 Small molecules enhance the potency of natural antimicrobial peptides
Losasso, V.; Agarwal, K.; Waskar, M.; Majumdar, A.; Crain, J.; Winn, M.; Hoptroff, M.
10.1101/2021.07.06.451332 — molecular biology — Posted on 2021-07-06
3341 The molecular mechanism of cytoadherence to placenta or tumor cells through VAR2CSA from Plasmodium falciparum
Wang, W.; Wang, Z.; Yang, X.; Gao, Y.; Zhang, X.; Cao, L.; Dai, A.; Sun, J.; Sun, L.; Jiang, L.; Chen, Z.; Wang, L.
10.1101/2021.07.06.451098 — biophysics — Posted on 2021-07-06
3344 Tumour Suppressor Parafibromin/Hyrax Governs Cell Polarity and Centrosome Assembly in Neural Stem Cells
Deng, Q.; Wang, C.; Koe, C. T.; Heinen, J. P.; Tan, Y. S.; Li, S.; GONZALEZ, C.; Sung, W.-K.; Wang, H.
10.1101/2021.07.06.451232 — developmental biology — Posted on 2021-07-06
3348 Irisin stimulates the release of CXCL1 from differentiating human subcutaneous and deep-neck derived adipocytes via upregulation of NFκB pathway
Shaw, A.; B. Toth, B.; Kiraly, R.; Arianti, R.; Csomos, I.; Poliska, S.; Vamos, A.; Korponay-Szabo, I. R.; Bacso, Z.; Györy, F.; Fesüs, L.; Kristof, E.
10.1101/2021.07.06.451152 — cell biology — Posted on 2021-07-06
3349 UVC inactivation of pathogenic samples suitable for cryoEM analysis
Depelteau, J. S.; Renault, L.; Althof, N.; Cassidy, C. K.; Mendonca, L. M.; Jensen, G. J.; Resch, G. P.; Briegel, A.
10.1101/2021.07.06.451241 — molecular biology — Posted on 2021-07-06
3350 Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autism
Bridi, M.; Luo, N.; Kim, G.; O'Ferrall, C.; Oatel, R.; Bertrand, S.; Kannan, S.; Kirkwood, A.
10.1101/2021.07.05.451213 — neuroscience — Posted on 2021-07-06
3351 Adolescent dopamine neurons represent reward differently during action and state guided learning
McCane, A.; Wegener, M.; Faraji, M.; Garcia, M. R.; Wallin-Miller, K.; Costa, V.; Moghaddam, B.
10.1101/2021.07.05.451195 — neuroscience — Posted on 2021-07-06
3354 Discovery of putative Golgi S-Adenosyl methionine transporters reveals the importance of plant cell wall polysaccharide methylation
Temple, H.; Phyo, P.; Yang, W.; Lyczakowski, J. J.; Echevarria-Poza, A.; Yakunin, I.; Parra-Rojas, J. P.; Terrett, O. M.; Saez-Aguayo, S.; Dupree, R.; Orellana, A.; Hong, M.; Dupree, P.
10.1101/2021.07.06.451061 — plant biology — Posted on 2021-07-06
3356 Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms
Pividori, M.; Lu, S.; Li, B.; Su, C.; Johnson, M. E.; Wei, W.-Q.; Feng, Q.; Namjou, B.; Kiryluk, K.; Kullo, I.; Luo, Y.; Sullivan, B. D.; Skarke, C.; Ritchie, M. D.; Grant, S. F. A.; Greene, C. S.
10.1101/2021.07.05.450786 — bioinformatics — Posted on 2021-07-06
3358 Population-level inference for home-range areas
Fleming, C. H.; Deznabi, I.; Alavi, S.; Crofoot, M. C.; Hirsch, B. T.; Medici, E. P.; Noonan, M. J.; Kays, R.; Fagan, W. F.; Sheldon, D.; Calabrese, J. M.
10.1101/2021.07.05.451204 — ecology — Posted on 2021-07-06
3360 Differential impact of Kv8.2 loss on rod and cone signaling and degeneration.
Inamdar, S. M.; Lankford, C. K.; Poria, D.; Laird, J. G.; Solessio, E.; Kefalov, V. J.; Baker, S. A.
10.1101/2021.07.05.451197 — neuroscience — Posted on 2021-07-06
3363 Genetic characterization of outbred Sprague Dawley rats and utility for genome-wide association studies
Gileta, A. F.; Fitzpatrick, C. J.; Chitre, A. S.; St. Pierre, C. L.; Joyce, E. V.; Maguire, R. J.; McLeod, A. M.; Gonzales, N. M.; Williams, A. E.; Morrow, J. D.; Robinson, T. E.; Flagel, S. B.; Palmer, A. A.
10.1101/412924 — genetics — Posted on 2021-07-06
3365 Relaxation time asymmetry in stator dynamics of the bacterial flagellar motor
Perez-Carrasco, R.; Franco-Onate, M.-J.; Walter, J.-C.; Dorignac, J.; Geniet, F.; Palmeri, J.; Parmeggiani, A.; Walliser, N.-O.; Nord, A. L.
10.1101/2021.07.05.451114 — biophysics — Posted on 2021-07-06
3367 Mapping the glycosyltransferase fold landscape using deep learning
Taujale, R.; Zhou, Z.; Yeung, W.; Moremen, K. W.; Li, S.; Kannan, N.
10.1101/2021.07.05.451183 — bioinformatics — Posted on 2021-07-06
3368 The crucial role of genome-wide genetic variation in conservation
Kardos, M.; Armstrong, E.; Fitzpatrick, S. W.; Hauser, S.; Hedrick, P.; Miller, J.; Tallmon, D.; Funk, W. C.
10.1101/2021.07.05.451163 — evolutionary biology — Posted on 2021-07-06
3369 Message in a Bottle, Metabarcoding Enables Biodiversity Comparisons Across Ecoregions
Steinke, D.; deWaard, S. L.; Sones, J. E.; Ivanova, N. V.; Prosser, S. W.; Perez, K.; Braukmann, T. W. A.; Milton, M.; Zakharov, E.; deWaard, J. R.; Ratnasingham, S.; Hebert, P. D. N.
10.1101/2021.07.05.451165 — ecology — Posted on 2021-07-06
3372 Transcriptional heterogeneity of ventricular zone cells throughout the embryonic mouse forebrain
Lee, D. R.; Rhodes, C.; Mitra, A.; Zhang, Y.; Maric, D.; Dale, R. K.; Petros, T. J.
10.1101/2021.07.05.451224 — neuroscience — Posted on 2021-07-06
3374 Inhibitory control of synaptic signals preceding motor action in mouse frontal cortex
Zhang, C.; Koukouli, F.; Allegra, M.; Ortiz, C.; Kao, H.-L.; Maskos, U.; Changeux, J.-P.; Schmidt-Hieber, C.
10.1101/2021.07.05.451151 — neuroscience — Posted on 2021-07-06
3376 A Distributed Network for Multimodal Experiential Representation of Concepts
Tong, J.-Q.; Binder, J. R.; Humphries, C. J.; Conant, L. L.; Fernandino, L.
10.1101/2021.07.05.451188 — neuroscience — Posted on 2021-07-06
3377 Genome sequences of the five Sitopsis species of Aegilops and the origin of polyploid wheat B-subgenome
Li, L.; Zhang, Z.; Wang, Z.; Li, N.; Sha, Y.; Wang, X.; Ding, N.; Li, Y.; Zhao, J.; Wu, Y.; Gong, L.; Mafessoni, F.; Levy, A.; Liu, B.
10.1101/2021.07.05.444401 — evolutionary biology — Posted on 2021-07-06
3378 Adenylate Kinase 2 deficiency causes NAD+ depletion and impaired purine metabolism during myelopoiesis
Wang, W.; DeVilbiss, A.; Arreola, M.; Mathews, T.; Martin-Sandoval, M.; Zhao, Z.; Awani, A.; Dever, D.; Al-Herz, W.; Noratangelo, L.; Porteus, M. H.; Morrison, S. J.; Weinacht, K. G.
10.1101/2021.07.05.450633 — cell biology — Posted on 2021-07-06
3380 Female meiosis II and pronuclear fusion require Bicaudal-D
Vazquez Pianzola, M. P.; Beuchle, D.; Saro, G.; Hernandez, G.; Maldonado, G.; Brunssen, D.; Meister, P.; Suter, B.
10.1101/2020.12.22.423980 — developmental biology — Posted on 2021-07-06
3381 Pulling the strings of cell cycle: a non-coding RNA, CcnA, modulates the master regulators CtrA and GcrA in Caulobacter crescentus
Beroual, W.; Lalaouna, D.; Benzaina, N.; Valette, O.; Prevost, K.; Denis, Y.; Djendli, M.; Brasseur, G.; Brilli, M.; Robledo, M.; Jimenez Zurdo, J. I.; Masse, E.; Biondi, E. G.
10.1101/756452 — microbiology — Posted on 2021-07-06
3385 A computationally designed fluorescent biosensor for D-serine
Vongsouthi, V.; Whitfield, J. H.; Unichenko, P.; Mitchell, J. A.; Breithausen, B.; Khersonsky, O.; Kremers, L.; Janovjak, H.; Monai, H.; Hirase, H.; Fleishman, S. J.; Henneberger, C.; Jackson, C. J.
10.1101/2020.08.18.255380 — biochemistry — Posted on 2021-07-06
3386 A Kozak-related non-coding deletion effectively increases B.1.1.7 transmissibility
Yang, J.; Zhang, G.; Yu, D.; Cao, R.; Wu, X.; Ling, Y.; Pan, Y.-H.; Yi, C.; Sun, X.; Sun, B.; Zhang, Y.; Zhao, G.-P.; Li, Y.; Li, H.
10.1101/2021.04.30.442029 — evolutionary biology — Posted on 2021-07-06
3388 All-trans retinoic acid induces synaptopodin-dependent metaplasticity in mouse dentate granule cells
Lenz, M.; Eichler, A.; Kruse, P.; Muellerleile, J.; Deller, T.; Jedlicka, P.; Vlachos, A.
10.1101/2021.07.05.451170 — neuroscience — Posted on 2021-07-06
3390 ZETA: a parameter-free statistical test for neuronal responsiveness
Montijn, J. S.; Seignette, K.; Howlett, M. H.; Cazemier, J. L.; Kamermans, M.; Levelt, C. N.; Heimel, J. A.
10.1101/2020.09.24.311118 — neuroscience — Posted on 2021-07-06
3394 Antisense-mediated repression of SAGA-dependent genes involves the HIR histone chaperone
Soudet, J.; Beyrouthy, N.; Pastucha, A. M.; Maffioletti, A.; Bakir, Z.; Stutz, F.
10.1101/2021.07.05.451174 — molecular biology — Posted on 2021-07-06
3395 Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques
He, W.-t.; Yuan, M.; Callaghan, S.; Musharrafieh, R.; Song, G.; Silva, M.; Beutler, N.; Lee, W.-H.; Yong, P.; Torres, J. L.; Melo, M.; Zhou, P.; Zhao, F.; Zhu, X.; Peng, L.; Huang, D.; Anzanello, F.; Ricketts, J.; Parren, M.; Garcia, E.; Ferguson, M.; Rinaldi, W.; Rawlings, S. A.; Nemazee, D.; Smith, D. M.; Briney, B.; Safonova, Y.; Rogers, T.; Crotty, S.; Irvine, D. J.; Ward, A. B.; Wilson, I. A.; Burton, D. R.; Andrabi, R.
10.1101/2021.07.05.451222 — immunology — Posted on 2021-07-06
3397 Members of the CUGBP Elav-Like Family of RNA-Binding Proteins are Expressed in Distinct Populations of Primary Sensory Neurons
Grlickova-Duzevik, E.; Michael, M.; McGrath-Conwell, A.; Neufeld, P. K.; Reimonn, T. M.; Molliver, D. C.; Harrison, B. J.
10.1101/2021.07.05.451166 — neuroscience — Posted on 2021-07-06
3398 D-cysteine is an endogenous regulator of neural progenitor cell dynamics in the mammalian brain
Semenza, E. R.; Harraz, M. M.; Abramson, E.; Malla, A. P.; Vasavda, C.; Gadalla, M. M.; Kornberg, M. D.; Snyder, S. H.; Roychaudhuri, R.
10.1101/2021.07.05.451211 — neuroscience — Posted on 2021-07-06
3400 p53-mediated neurodegeneration in the absence of the nuclear protein Akirin2
Peek, S. L.; Bosch, P. J.; Bahl, E.; Iverson, B. J.; Parida, M.; Bais, P.; Manak, J. R.; Michaelson, J.; Burgess, R. W.; Weiner, J. A.
10.1101/2021.07.05.451155 — neuroscience — Posted on 2021-07-06
3401 CALR frameshift mutations in MPN patient-derived iPS cells accelerate maturation of megakaryocytes
Olschok, K.; Han, L.; de Toledo, M. A. S.; Boehnke, J.; Grasshoff, M.; Costa, I. G.; Theocharides, A.; Maurer, A.; Schueler, H. M.; Buhl, E. M.; Pannen, K.; Baumeister, J.; Kalmer, M.; Gupta, S.; Boor, P.; Gezer, D.; Bruemmendorf, T. H.; Zenke, M.; Chatain, N.; Koschmieder, S.
10.1101/2021.07.05.451130 — cancer biology — Posted on 2021-07-05
3403 Increased Histone-DNA Complexes and Endothelial-Dependent Thrombin Generation in Severe COVID-19
Bouchard, B. A.; Colovos, C.; Lawson, M.; Sackhiem, A.; Mould, K. J.; Janssen, W. J.; Cohen, M. J.; Majumdar, D.; Freeman, K.
10.1101/2021.07.03.450992 — biochemistry — Posted on 2021-07-05
3404 Feeding effects on liver mitochondrial bioenergetics of Boa constrictor (Serpentes: Boidae)
Araujo, H. R. M.; Sartori, M. R.; Navarro, C. D. C.; de Carvalho, J. E.; Cruz, A. L.
10.1101/2021.07.05.451168 — biochemistry — Posted on 2021-07-05
3405 Protease Resistance of ex vivo Amyloid Fibrils implies the proteolytic Selection of disease-associated Fibril Morphologies
Schoenfelder, J.; Pfeiffer, P. B.; Pradhan, T.; Bijzet, J.; Hazenberg, B. P. C.; Schoenland, S. O.; Hegenbart, U.; Reif, B.; Haupt, C.; Faendrich, M.
10.1101/2021.07.05.451219 — biochemistry — Posted on 2021-07-06
3406 A PKA Inhibitor Motif within Smoothened Controls Hedgehog Signal Transduction
Happ, J. T.; Arveseth, C. D.; Bruystens, J.; Bertinetti, D.; Nelson, I. B.; Olivieri, C.; Hedeen, D. S.; Zhu, J.-F.; Capener, J. L.; Bröckel, J. W.; Vu, L.; King, C. C.; Ruiz-Perez, V. L.; Veglia, G.; Herberg, F. W.; Taylor, S. S.; Myers, B. R.
10.1101/2021.07.05.451193 — biochemistry — Posted on 2021-07-06
3407 Construction of a new chromosome-scale, long-read reference genome assembly of the Syrian hamster, Mesocricetus auratus
Harris, R. A.; Raveendran, M.; Lyfoung, D. T.; Sedlazeck, F. J.; Mahmoud, M.; Prall, T.; Karl, J.; Doddapaneni, H.; Meng, Q.; Han, Y.; Muzny, D.; Wiseman, R. W.; O'Connor, D. H.; Rogers, J.
10.1101/2021.07.05.451071 — genomics — Posted on 2021-07-05
3410 Exocyst Inactivation in Urothelial Cells Disrupts Autophagy and Activates non-canonical NF-κB
Ortega, M. A.; Villiger, R. K.; Harrison-Chau, M.; Lieu, S.; Tamashiro, K.-K.; Lee, A. J.; Fujimoto, B. A.; Patwardhan, G. Y.; Kepler, J.; Fogelgren, B.
10.1101/2021.07.05.451173 — developmental biology — Posted on 2021-07-05
3412 Optimized nickase- and nuclease-based prime editing in human and mouse cells
Adikusuma, F.; Lushington, C.; Arudkumar, J.; Godahewa, G. I.; Chey, Y. C. J.; Gierus, L.; Piltz, S.; Reti, D.; Wilson, L.; Bauer, D.; Thomas, P.
10.1101/2021.07.01.450810 — molecular biology — Posted on 2021-07-05
3415 Immunisation of ferrets and mice with recombinant SARS-CoV-2 spike protein formulated with Advax-SM adjuvant protects against COVID-19 infection
Li, L.; Honda-Okubo, Y.; Huang, Y.; Jang, H.; Carlock, M. A.; Baldwin, J.; Piplani, S.; Bebin-Blackwell, A. G.; Forgacs, D.; Sakamoto, K.; Stella, A.; Turville, S.; Chataway, T.; Colella, A.; Triccas, J.; Ross, T.; Petrovsky, N.
10.1101/2021.07.03.451026 — immunology — Posted on 2021-07-05
3419 Dynamics of SARS-CoV-2 host cell interactions inferred from transcriptome analyses
Adam, L.; Stanifer, M.; Springer, F.; Mathony, J.; Di Ponzio, C.; Eils, R.; Boulant, S.; Niopek, D.; Kallenberger, S. M.
10.1101/2021.07.04.450986 — systems biology — Posted on 2021-07-05
3420 A SARS-CoV-2 nucleocapsid protein TR-FRET assay amenable to high-throughput screening
Gorshkov, K.; Vasquez, D. M.; Chiem, K.; Ye, C.; Nguyen Tran, B.; de la Torre, J. C.; Moran, T.; Chen, C. Z.; Martinez-Sobrido, L.; Zheng, W.
10.1101/2021.07.03.450938 — pharmacology and toxicology — Posted on 2021-07-05
3422 Sexually distinct song cultures in a songbird metapopulation
Webb, W. H.; Roper, M. M.; Pawley, M. D.; Fukuzawa, Y.; Harmer, A. M.; Brunton, D. H.
10.1101/2021.07.05.451205 — animal behavior and cognition — Posted on 2021-07-05
3424 χ-separation: Magnetic susceptibility source separation toward iron and myelin mapping in the brain
Shin, H.-G.; Lee, J.; Yun, Y. H.; Yoo, S. H.; Jang, J.; Oh, S.-H.; Nam, Y.; Jung, S.; Kim, S.; Fukunaga, M.; Kim, W.; Choi, H. J.; Lee, J.
10.1101/2020.11.07.363796 — neuroscience — Posted on 2021-07-05
3425 Precise optical control of gene expression in C. elegans using genetic code expansion and Cre recombinase
Davis, L.; Radman, I.; Goutou, A.; Tynan, A.; Baxter, K.; Xi, Z.; O'Shea, J. M.; Chin, J. W.; Greiss, S.
10.1101/2020.05.02.072363 — neuroscience — Posted on 2021-07-05
3428 Coding and regulatory variants affect serum protein levels and common disease
Emilsson, V.; Gudmundsdottir, V.; Gudjonsson, A.; Karim, M. A.; Ilkov, M.; Staley, J. R.; Gudmundsson, E. F.; Jonsson, B. G.; Launer, L. J.; Lindeman, J. H.; Morton, N. M.; Aspelund, T.; Lamb, J. R.; Jennings, L. L.; Gudnason, V.
10.1101/2020.05.06.080440 — genetics — Posted on 2021-07-05
3429 Diet unmasks genetic variants that regulate lifespan in outbred Drosophila
Pallares, L. F.; Lea, A. J.; Han, C.; Filippova, E. V.; Andolfatto, P.; Ayroles, J. F.
10.1101/2020.10.19.346312 — evolutionary biology — Posted on 2021-07-05
3430 The role of ventromedial prefrontal cortex in reward valuation and future thinking during intertemporal choice
Ciaramelli, E.; De Luca, F.; Kwan, D.; Mok, J. N. Y.; Bianconi, F.; Knyagnytska, V.; Craver, C.; Green, L.; Myerson, J.; Rosenbaum, S.
10.1101/2021.03.15.435400 — neuroscience — Posted on 2021-07-05
3431 Peripheral CB1 receptor blockade acts as a memory enhancer through an adrenergic-dependent mechanism
Martinez-Torres, S.; Bergada-Martinez, A.; Ortega, J.; Galera-Lopez, L.; Hervera Abad, A.; Ortega-Alvaro, A.; Remmers, F.; Munoz-Moreno, E.; Soria, G.; del Rio, J. A.; Lutz, B.; Ruiz-Ortega, J. A.; Meana, J. J.; Maldonado, R.; Ozaita, A.
10.1101/2021.06.16.448227 — neuroscience — Posted on 2021-07-05
3435 Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models
de Rus Jacquet, A.; Ambaw, A.; Tambe, M. A.; Ma, S. Y.; Timmers, M.; Grace, M. H.; Wu, Q.-L.; Simon, J. E.; McCabe, G. P.; Lila, M. A.; Shi, R.; Rochet, J.-C.
10.1101/2020.12.01.391268 — pharmacology and toxicology — Posted on 2021-07-05
3436 Stat3 co-operates with mutant Ezh2Y641F to regulate gene expression and limit the anti-tumor immune response in melanoma
Zimmerman, S.; Nixon, S. J.; Chen, P. Y.; Raj, L.; Smith, S.; Paolini, R. L.; Lin, P. N.; Souroullas, G. P.
10.1101/2021.06.01.446580 — cancer biology — Posted on 2021-07-05
3444 Single-cell transcriptomics reveals a conserved metaplasia program in pancreatic injury
Ma, Z.; Lytle, N. K.; Chen, B.; Jyotsana, N.; Weiser Novak, S.; Cho, C. J.; Caplan, L.; Ben-Levy, O.; Neininger, A. C.; Burnette, D. T.; Trinh, V. Q.; Tan, M. C. B.; Patterson, E. A.; Arrojo e Drigo, R.; Giraddi, R. R.; Ramos, C.; Means, A. L.; Matsumoto, I.; Manor, U.; Mills, J. C.; Goldenring, J. R.; Lau, K.; Wahl, G.; DelGiorno, K. E.
10.1101/2021.04.09.439243 — cell biology — Posted on 2021-07-05
3445 Synaptic Encoding of Vestibular Sensation Regulates Movement Timing and Coordination
Hamling, K. R.; Harmon, K.; Greaney, M. R.; Dobler, Z.; Kimura, Y.; Higashijima, S.-i.; Schoppik, D.
10.1101/2021.07.05.451142 — neuroscience — Posted on 2021-07-05
3448 Perifornical Area Urocortin-3 Neurons Promote Infant-directed Neglect and Aggression
Autry, A. E.; Wu, Z.; Kohl, J.; Bambah-Mukku, D.; Rubinstein, N. D.; Marin-Rodriguez, B.; Carta, I.; Sedwick, V.; Dulac, C.
10.1101/697334 — neuroscience — Posted on 2021-07-05
3449 On the topochronic map of the human brain dynamics
Sorrentino, P.; Petkoski, S.; Sparaco, M.; Troisi Lopez, E.; Rucco, R.; Signoriello, E.; Baselice, F.; Bonavita, S.; Pirozzi, M. A.; Quarantelli, M.; Sorrentino, G.; Jirsa, V.
10.1101/2021.07.01.447872 — neuroscience — Posted on 2021-07-05
3451 Deficits in Behavioral and Neuronal Pattern Separation in Temporal Lobe Epilepsy
Madar, A. D.; Pfammatter, J. A.; Bordenave, J.; Plumley, E. I.; Ravi, S.; Cowie, M.; Wallace, E. P.; Hermann, B. P. D.; Maganti, R. K.; Jones, M. V.
10.1101/2020.02.13.948364 — neuroscience — Posted on 2021-07-05
3456 In vivo modelling of patient genetic heterogeneity identifies concurrent Wnt and PI3K activity as a potent driver of invasive cholangiocarcinoma growth.
Younger, N.; Wilson, M.; Jarman, E.; Meynert, A.; Grimes, G.; Gournopanos, K.; Waddell, S.; Tennant, P.; Wilson, D.; Guest, R.; Wigmore, S.; Acosta, J. C.; Kendall, T. J.; Taylor, M.; Sproul, D.; Mill, P.; Boulter, L.
10.1101/2021.07.05.449722 — cancer biology — Posted on 2021-07-05
3458 A new platform for high-throughput therapy testing on iPSC-derived, immature airway from Cystic Fibrosis Patients
Jiang, J. X.; Wellhauser, L.; Laselva, O.; Utkina, I.; Bozoky, Z.; Gunawardena, T.; Ngan, Z.; Xia, S.; Eckford, P. D. W.; Ratjen, F.; Moraes, T. J.; Parkinson, J.; Wong, A. P.; Bear, C.
10.1101/2021.07.05.451013 — genomics — Posted on 2021-07-05
3460 Cyp26b1 restrains murine heart valve growth during development
Ahuja, N.; Hiltabildle, M. S.; Rajasekhar, H.; Daniel, E.; Barlow, H. R.; Voss, S.; Cleaver, O.; Maynard, C.
10.1101/2021.07.05.450958 — developmental biology — Posted on 2021-07-05
3463 Aberrant motor contagion of emotions in psychopathy and high-functioning autism
Sun, L.; Lukkarinen, L.; Noppari, T.; Nazari-Farsani, S.; Putkinen, V. J.; Seppala, K.; Hudson, M.; Tani, P.; Lindberg, N.; Karlsson, H.; Hirvonen, J.; Salomaa, M.; Venetjoki, N.; Lauerma, H.; Tiihonen, J.; Nummenmaa, L.
10.1101/2021.07.05.450842 — neuroscience — Posted on 2021-07-05
3466 Hydrogel-based slow release of a receptor-binding domain subunit vaccine elicits neutralizing antibody responses against SARS-CoV-2
Gale, E. C.; Powell, A. E.; Roth, G. A.; Ou, B. S.; Meany, E. L.; Grosskopf, A. K.; Adamska, J.; Picece, V. C. T. M.; d'Aquino, A. I.; Pulendran, B.; Kim, P. S.; Appel, E.
10.1101/2021.03.31.437792 — bioengineering — Posted on 2021-07-05
3469 An Immune Cell Atlas Reveals Dynamic COVID-19 Specific Neutrophil Programming Amenable to Dexamethasone Therapy
Sinha, S.; Rosin, N.; Arora, R.; Labit, E.; Jaffer, A.; Cao, L.; Farias, R.; Nguyen, A. P.; de Almeida, L. G. N.; Dufour, A.; Bromley, A.; McDonald, B.; Gillrie, M.; Fritzler, M. J.; Yipp, B.; Biernaskie, J.
10.1101/2021.04.18.440366 — immunology — Posted on 2021-07-05
3473 Disturbance-based management of ecosystem services and disservices in partial nitritation anammox biofilms
Suarez, C.; Sedlacek, C. J.; Gustavsson, D. J. I.; Eiler, A.; Modin, O.; Hermansson, M.; Persson, F.
10.1101/2021.07.05.451122 — microbiology — Posted on 2021-07-05
3475 Generation, quality control, and analysis of the first genomically humanised knock-in mice for the ALS/FTD genes SOD1, TARDBP (TDP-43), and FUS
Devoy, A.; Price, G.; De Giorgio, F.; Bunton-Stasyshyn, R.; Thompson, D.; Gasco, S.; Allan, A.; Codner, G. F.; Nair, R. R.; Tibbit, C.; McLeod, R.; Ali, Z.; Noda, J.; Marrero-Gagliardi, A.; Brito-Armas, J. M.; Simon, M.; ONeill, E.; Harrison, J.; Atkins, G.; Corrochano, S.; Stewart, M.; Teboul, L.; Acevedo Arozena, A.; Fisher, E. M.; Cunningham, T. J.
10.1101/2021.07.05.451113 — neuroscience — Posted on 2021-07-05
3476 The Dilemma Of Disobedience: An ERP study
Fabre, E. F.; Causse, M.; Othon, M.; Vanderhenst, J.-B.
10.1101/2021.07.05.451127 — neuroscience — Posted on 2021-07-05
3477 Investigating facial information content in the hand area of individuals with a congenital and acquired missing hand
Root, V.; Muret, D.; Arribas, M.; Amoruso, E.; Thornton, J.; Tarall-Jozwiak, A.; Tracey, I.; Makin, T.
10.1101/2021.07.05.451126 — neuroscience — Posted on 2021-07-05
3478 Direct neuronal reprogramming by temporal identity factors
Boudreau-Pinsonneault, C.; Javed, A.; Fries, M.; Mattar, P.; Cayouette, M.
10.1101/2021.07.05.451124 — neuroscience — Posted on 2021-07-05
3479 CXCL17 is an endogenous inhibitor of CXCR4 via a novel mechanism of action
White, C. W.; Kilpatrick, L. E.; Dale, N.; Abhayawardana, R. S.; Dekkers, S.; Stocks, M. J.; Pfleger, K. D.; Hill, S. J.
10.1101/2021.07.05.451109 — pharmacology and toxicology — Posted on 2021-07-05
3480 Multifaceted roles of SAMHD1 in cancer
McLaughlin, K.-M.; Cinatl, J.; Wass, M. N.; Michaelis, M.
10.1101/2021.07.03.451003 — cancer biology — Posted on 2021-07-05
3484 Stable Isotope Tracing In Vivo Reveals A Metabolic Bridge Linking The Microbiota To Host Histone Acetylation
Lund, P. J.; Gates, L. A.; Leboeuf, M.; Smith, S. A.; Chau, L.; Friedman, E. S.; Lopes, M.; Saiman, Y.; Kim, M. S.; Petucci, C.; Allis, C. D.; Wu, G. D.; Garcia, B. A.
10.1101/2021.07.05.450926 — biochemistry — Posted on 2021-07-05
3486 Sand dropseed (Sporobolus cryptandrus) - A new pest in Eurasian sand areas?
Torok, P.; Schmidt, D.; Batori, Z.; Aradi, E.; Kelemen, A.; Habenczyus, A. A.; Diaz, P.; Tolgyesi, C.; Pal, R. W.; Balogh, N.; Toth, E.; Matus, G.; Taborska, J.; Sramko, G.; Laczko, L.; Jordan, S.; Sonkoly, J.
10.1101/2021.07.05.451115 — ecology — Posted on 2021-07-05
3488 Periosteum-derived podoplanin-expressing stromal cells regulate nascent vascularization during epiphyseal marrow development
Tamura, S.; Mukaide, M.; Katsuragi, Y.; Fujii, W.; Odaira, K.; Suzuki, N.; Okamoto, S.; Suzuki, A.; Kanematsu, T.; Katsumi, A.; Takagi, A.; Suzuki-Inoue, K.; Matsushita, T.; Kojima, T.; Hayakawa, F.
10.1101/2021.07.05.451096 — developmental biology — Posted on 2021-07-05
3489 Embigin deficiency leads to delayed embryonic lung development and high neonatal mortality
Talvi, S.; Jokinen, J.; Sipila, K. H.; Rappu, P.; Zhang, F.; Poutanen, M.; Rantakari, P.; Heino, J.
10.1101/2021.07.05.451131 — developmental biology — Posted on 2021-07-05
3490 The E3 Ubiquitin Ligase Mindbomb1 controls zebrafish Planar Cell Polarity
Saraswathy, V. M.; Sharma, P.; Kurup, A. J.; Poles, S.; Poulain, M.; Fürthauer, M.
10.1101/2021.07.05.451064 — developmental biology — Posted on 2021-07-05
3491 A chromatin phase transition protects mitotic chromosomes against microtubule perforation
Schneider, M. W. G.; Gibson, B. A.; Otsuka, S.; Spicer, M. F. D.; Petrovic, M.; Blaukopf, C.; Langer, C. C. H.; Doolittle, L. K.; Rosen, M. K.; Gerlich, D. W.
10.1101/2021.07.05.450834 — cell biology — Posted on 2021-07-05
3492 Reversal of the renal hyperglycemic memory by targeting sustained tubular p21 expression
Al-Dabet, M. M.; Shahzad, K.; Elwakiel, A.; Sulaj, A.; Kopf, S.; Bock, F.; Gadi, I.; Zimmermann, S.; Rana, R.; Krishnan, S.; Gupta, D.; Nazir, S.; Baber, R.; Scholz, M.; Geffers, R.; Mertens, P. R.; Nawroth, P. P.; Griffin, J.; Dockendorff, C.; Kohli, S.; Isermann, B.
10.1101/2021.07.05.450846 — molecular biology — Posted on 2021-07-05
3493 Novel microbial syntrophies identified by longitudinal metagenomics
Raguideau, S.; Trego, A.; Farrell, F.; Collins, G.; Quince, C.; Soyer, O. S.
10.1101/2021.07.05.451125 — microbiology — Posted on 2021-07-05
3496 Topography-induced large-scale anti-parallel collective migration in vascular endothelium
Leclech, C.; Gonzalez-Rodriguez, D.; Villedieu, A.; Lok, T.; Déplanche, A.-M.; Barakat, A. I.
10.1101/2021.07.05.451106 — biophysics — Posted on 2021-07-05
3499 Polygenic routes lead to parallel altitudinal adaptation in Heliosperma pusillum (Caryophyllaceae)
Szukala, A.; Lovegrove-Walsh, J.; Luqman, H.; Fior, S.; Wolfe, T. M.; Frajman, B.; Schoenswetter, P.; Paun, O.
10.1101/2021.07.05.451094 — evolutionary biology — Posted on 2021-07-05
3502 A bacterial derived plant- mimicking cytokinin hormone regulates social behaviour in a rice pathogen
Deb, S.; Kumar, C.; Kumar, R.; Kaur, A.; Ghosh, P.; Jha, G.; Patil, P. B.; Chatterjee, S.; Patel, H. K.; Sonti, R. V.
10.1101/2021.07.05.451090 — microbiology — Posted on 2021-07-05
3503 Global evolutionary dynamics and resistome analysis of Clostridioides difficile ribotype 017
Imwattana, K.; Putsathit, P.; Leepattarakit, T.; Kiratisin, P.; Riley, T. V.; Knight, D. R.
10.1101/2021.07.04.451084 — microbiology — Posted on 2021-07-05
3506 Divergent effects of absolute evidence magnitude on decision accuracy and confidence in perceptual judgements
Ko, Y. H.; Feuerriegel, D. C.; Turner, W.; Overhoff, H.; Niessen, E.; Stahl, J.; Hester, R.; Fink, G. R.; Weiss, P. H.; Bode, S.
10.1101/2021.07.04.451079 — neuroscience — Posted on 2021-07-05
3510 Molecular Determinants of Complexin Clamping in Reconstituted Single-Vesicle Fusion
Bera, M.; Ramakrishnan, S.; Coleman, J.; Krishnakumar, S. S.; Rothman, J. E.
10.1101/2021.07.05.451112 — biophysics — Posted on 2021-07-05
3511 C-STEM: ENGINEERING NICHE-LIKE MICRO-COMPARTMENTS FOR OPTIMAL AND SCALE-INDEPENDENT EXPANSION OF HUMAN PLURIPOTENT STEM CELLS IN BIOREACTORS
Cohen, P. J. R.; Luquet, E.; Pletenka, J.; Leonard, A.; Warter, E.; Gurchenkov, B.; Carrere, J.; Rieu, C.; Hardouin, J.; Moncaubeig, F.; Lanero, M.; Quelennec, E.; Wurtz, H.; Jamet, E.; Demarco, M.; banal, C.; Van Liedekerke, P.; Nassoy, P.; Feyeux, M.; Lefort, N.; Alessandri, k.
10.1101/2021.07.05.451086 — bioengineering — Posted on 2021-07-05
3513 Fly Cell Atlas: a single-cell transcriptomic atlas of the adult fruit fly
Li, H.; Janssens, J.; De Waegeneer, M.; Kolluru, S. S.; Davie, K.; Gardeux, V.; Sealens, W.; David, F.; Brbic, M.; Leskovec, J.; McLaughlin, C.; Xie, Q.; Jones, R.; Brueckner, K.; Shim, J.; Tattikota, S. G.; Schnorrer, F.; Rust, K.; Nystul, T.; Carvalho-Santos, Z.; Ribeiro, C.; Pal, S.; Przytycka, T. M.; Allen, A.; Goodwin, S.; Berry, C.; Fuller, M. T.; White-Cooper, H.; Matunis, E.; DiNardo, S.; Galenza, A.; O'Brien, L. E.; Dow, J. A. T.; FCA Consortium, ; Jasper, H.; Oliver, B.; Perrimon, N.; Deplancke, B.; Quake, S.; Luo, L.; Aerts, S.
10.1101/2021.07.04.451050 — genomics — Posted on 2021-07-05
3515 Phylogenomic analysis of Uganda influenza type-A viruses to assess their relatedness to the vaccine strains and other Africa viruses: a molecular epidemiology study.
Nabakooza, G.; Owuor, D. C.; R. de Laurent, Z.; Owor, N.; Kayiwa, J. T.; Jjingo, D.; Agoti, C. N.; Nokes, D. J.; Kateete, D. P.; Kitayimbwa, J. M.; Frost, S. D. W.; Lutwama, J. J.
10.1101/2021.07.05.451078 — evolutionary biology — Posted on 2021-07-05
3516 Gut microbial diversity in stingless bees is linked to host wing size and is influenced by geography
Liu, H.; Hall, M. A.; Brettell, L.; Halcroft, M.; Wang, J.; Nacko, S.; Spooner-Hart, R.; Cook, J.; Riegler, M.; Singh, B.
10.1101/2021.07.04.451070 — ecology — Posted on 2021-07-05
3518 A new transgene mouse model using an extravesicular EGFP tag to elucidate the in vivo function of extracellular vesicles
Noegaard, M. O.; Steffensen, L. B.; Hansen, D.; Fuchtbauer, E.-M.; Engelund, M. B.; Dimke, H.; Andersen, D. C.; Svenningsen, P.
10.1101/2021.07.05.451120 — molecular biology — Posted on 2021-07-05
3523 Pro-inflammatory Cytokine GM-CSF Improves Learning/Memory and Brain Pathology in Dp16 Down Syndrome Mice and Improves Learning/Memory in Wild-Type Mice
Ahmed, M. M.; Wang, A.; Elos, M.; Chial, H.; Sillau, S.; Solano, A.; Coughlan, C.; Aghili, L.; Anton, P.; Markham, N.; Adame, V.; Gardiner, K.; Boyd, T.; Potter, H.
10.1101/2021.07.04.451073 — neuroscience — Posted on 2021-07-05
3526 Towards a Neurometric-based Construct Validity of Trust
Chen, P.-H. A.; Fareri, D.; Guroglu, B.; Delgado, M. R.; Chang, L. J.
10.1101/2021.07.04.451074 — neuroscience — Posted on 2021-07-05
3530 PHENOTYPIC CHARACTERIZATION OF TWO NOVEL CELL LINE MODELS OF CASTRATION RESISTANT PROSTATE CANCER.
Haffner, M. C.; Bhamidipati, A.; Tsai, H. K.; Esopi, D. M.; Vaghasia, A. M.; Low, J.-Y.; Patel, R. A.; Guner, G.; Pham, M.-T.; Castagna, N.; Hicks, J.; Wyhs, N.; Aebersold, R.; De Marzo, A. M.; Nelson, W. G.; Guo, T.; Yegnasubramanian, S.
10.1101/2021.07.04.450352 — cancer biology — Posted on 2021-07-05
3531 Deleting in vivo β-catenin degradation domain in mouse hepatocytes drives hepatocellular carcinoma or hepatoblastoma-like tumors
Loesch, R.; Caruso, S.; Paradis, V.; Godard, C.; Gougelet, A.; Picard, S.; Perret, C.; Taketo, M. M. M.; Zucman-Rossi, J.; Colnot, S.
10.1101/2021.07.04.450836 — cancer biology — Posted on 2021-07-05
3533 Open-source personal pipetting robots with live-cell incubation and microscopy compatibility
Dettinger, P.; Kull, T.; Arekatla, G.; Ahmed, N.; Zhang, Y.; Schneiter, F.; Wehling, A.; Schirmacher, D.; Kawamura, S.; Loeffler, D.; Schroeder, T.
10.1101/2021.07.04.448641 — bioengineering — Posted on 2021-07-05
3534 Self-organization of collective escape in pigeon flocks
Papadopoulou, M.; Hildenbrandt, H.; Sankey, D. W. E.; Portugal, S. J.; Hemelrijk, C. K.
10.1101/2021.07.04.450902 — animal behavior and cognition — Posted on 2021-07-05
3540 Mechanics defines the spatial pattern of compensatory proliferation
Kawaue, T.; Yow, I.; Le, A. P.; Lou, Y.; Loberas, M.; Shagirov, M.; Prost, J.; Hiraiwa, T.; Ladoux, B.; Toyama, Y.
10.1101/2021.07.04.451019 — cell biology — Posted on 2021-07-05
3545 Coding and regulatory variants affect serum protein levels and common disease
Emilsson, V.; Gudmundsdottir, V.; Ilkov, M.; Staley, J. R.; Gudmundsson, E. F.; Launer, L. J.; Lindeman, J. H.; Morton, N. M.; Aspelund, T.; Lamb, J. R.; Jennings, L. L.; Gudnason, V.; Gudjonsson, A.; Karim, M. A.; Jonsson, B. G.
10.1101/2020.05.06.080440 — genetics — Posted on 2021-07-05
3547 TLR4 regulation in human fetal membranes as an explicative mechanism of a pathological preterm case.
Belville, C.; Ponelle-Chachuat, F.; Rouzaire, M.; Gross, C.; Pereira, B.; Gallot, D.; Sapin, V.; BLANCHON, L.
10.1101/2021.06.28.450131 — cell biology — Posted on 2021-07-05
3548 Single-cell RNA sequencing-based characterization of resident lung mesenchymal stromal cells in bronchopulmonary dysplasia
Mizikova, I.; Lesage, F.; Cyr-Depauw, C.; Cook, D. P.; Hurskainen, M.; Hanninen, S.; Vadivel, A.; Bardin, P.; Zhong, S.; Carpen, O.; Vanderhyden, B. C.; Thebaud, B.
10.1101/2021.06.18.448928 — cell biology — Posted on 2021-07-05
3549 Fluctuations in TCR and pMHC interactions regulate T cell activation
Egan, J. R.; Abu-Shah, E.; Dushek, O.; Elliott, T.; MacArthur, B.
10.1101/2021.02.09.430441 — immunology — Posted on 2021-07-05
3551 Hippocampal sharp wave-ripples and the associated sequence replay emerge from structured synaptic interactions in a network model of area CA3
Ecker, A.; Bagi, B.; Vertes, E.; Steinbach-Nemeth, O.; Karlocai, M. R.; Papp, O. I.; Miklos, I.; Hajos, N.; Freund, T. F.; Gulyas, A. I.; Kali, S.
10.1101/2021.02.18.431868 — neuroscience — Posted on 2021-07-05
3552 Predicting speech from a cortical hierarchy of event-based timescales
Schmitt, L.-M.; Erb, J.; Tune, S.; Rysop, A.; Hartwigsen, G.; Obleser, J.
10.1101/2020.12.19.423616 — neuroscience — Posted on 2021-07-05
3553 Multi-omics-based label-free metabolic flux inference reveals obesity-associated dysregulatory mechanisms in liver glucose metabolism
Uematsu, S.; Ohno, S.; Tanaka, K. Y.; Hatano, A.; Kokaji, T.; Ito, Y.; Kubota, H.; Hironaka, K.-i.; Suzuki, Y.; Matsumoto, M.; Nakayama, K. I.; Hirayama, A.; Soga, T.; Kuroda, S.
10.1101/2021.06.21.449220 — systems biology — Posted on 2021-07-05
3555 Gasdermin B over-expression arbitrates HER2-targeted therapy resistance by inducing protective autophagy
Gamez-Chiachio, M.; Molina-Crespo, A.; Ramos-Nebot, C.; Martinez-Val, J.; Martinez, L.; Gassner, K.; Llobet, F. J.; Gonzalo-Consuegra, C.; Cordani, M.; Bernado-Morales, C.; Diaz, E.; Rojo-Sebastian, A.; Trivino, J. C.; Sanchez, L.; Rodriguez-Barrueco, R.; Arribas, J.; Llobet-Navas, D.; Sarrio, D.; Moreno-Bueno, G.
10.1101/2021.07.01.450506 — cancer biology — Posted on 2021-07-05
3556 Crop loss identification at field parcel scale using satellite remote sensing and machine learning
Hiremath, S.; Wittke, S.; Palosuo, T.; Kaivosoja, J.; Tao, F.; Proll, M.; Puttonen, E.; Peltonen-Sainio, P.; Marttinen, P.; Mamitsuka, H.
10.1101/2021.05.07.443072 — bioinformatics — Posted on 2021-07-05
3560 GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans
Nair, S.; Srivastava, C.; Brown, R. V.; Koli, S.; Choquet, H.; Kang, H. S.; Kuo, Y.-M.; Grimm, S. A.; Sutherland, C.; Badea, A.; Johnson, G. A.; Zhao, Y.; Yin, J.; Okamoto, K.; Kizhatil, K.; Borras, T.; Zode, G.; Clark, G.; Chakrabarti, S.; John, S. W. M.; Jorgenson, E.; Jetten, A. M.
10.1101/2021.07.02.450719 — molecular biology — Posted on 2021-07-05
3563 Characterisation of the transcriptional dynamics underpinning the function, fate, and migration of the mouse Anterior Visceral Endoderm
Thowfeequ, S.; Fiorentino, J.; Hu, D.; Solovey, M.; Ruane, S.; Whitehead, M.; Vanhaesebroeck, B.; Scialdone, A.; Srinivas, S.
10.1101/2021.06.25.449902 — developmental biology — Posted on 2021-07-05
3564 Mice and primates use distinct strategies for visual segmentation
Luongo, F. J.; Liu, L.; Ho, C. L. A.; Hesse, J. K.; Wekselblatt, J. B.; Lanfranchi, F.; Huber, D. K.; Tsao, D. Y.
10.1101/2021.07.04.451059 — neuroscience — Posted on 2021-07-05
3565 Dopaminergic axon tracts within a hyaluronic acid hydrogel encasement for implantation to restore the nigrostriatal pathway
Gordian-Velez, W. J.; Browne, K. D.; Galarraga, J. H.; Duda, J. E.; Espana, R. A.; Chen, H. I.; Burdick, J. A.; Cullen, D. K.
10.1101/2021.07.03.451006 — bioengineering — Posted on 2021-07-04
3572 Trycycler: consensus long-read assemblies for bacterial genomes
Wick, R. R.; Judd, L. M.; Cerdeira, L. T.; Hawkey, J.; Meric, G.; Vezina, B.; Wyres, K. L.; Holt, K. E.
10.1101/2021.07.04.451066 — bioinformatics — Posted on 2021-07-04
3573 Accurate Automatic Glioma Segmentation in Brain MRI images Based on CapsNet
Jalili Aziz, M.; Amiri Tehrani Zadeh, M. A.; Farnia, P.; Alimohammadi, M.; Makki Abadi, B.; Ahmadian, A.; Alirezaie, J.
10.1101/2021.07.03.450931 — bioengineering — Posted on 2021-07-04
3576 eQTL mapping using allele-specific gene expression
Zhabotynsky, V.; Huang, L.; Little, P.; Hu, Y.; Pardo Manuel de Villena, F. F.; Zou, F.; Sun, W.
10.1101/2021.07.03.450987 — genomics — Posted on 2021-07-04
3578 Bark beetles locate fungal symbionts by detecting volatile fungal metabolites of host tree resin monoterpenes
Kandasamy, D.; Zaman, R.; Nakamura, Y.; Zhao, T.; Hartmann, H.; Andersson, M. N.; Hammerbacher, A.; Gershenzon, J.
10.1101/2021.07.03.450988 — ecology — Posted on 2021-07-04
3582 Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation
Kang, J.; Pearson, R.; Zhu, H.; Chan, K. T.; Huang, X.; Blake, S.; Trigos, A. S.; Anderson, D.; Creek, D. J. S.; De Souza, D. P.; Wang, X.; Fu, C.; Jana, M.; Sanij, E.
10.1101/2021.07.04.451041 — cell biology — Posted on 2021-07-04
3584 Network-based identification and pharmacological targeting of host cell master regulators induced by SARS-CoV-2 infection
Laise, P.; Stanifer, M. L.; Bosker, G.; Sun, X.; Triana, S.; Doldan, P.; La Manna, F.; De Menna, M.; Realubit, R. B.; Pampou, S.; Karan, C.; Alexandrov, T.; Kruithof-de Julio, M.; Califano, A.; Boulant, S.; Alvarez, M. J.
10.1101/2021.07.03.451001 — microbiology — Posted on 2021-07-04
3585 Single-cell analysis uncovers differential regulation of lung γδ T cell subsets by the co-inhibitory molecules, PD-1 and TIM-3
Edwards, S. C.; Hedley, A.; Hoevenaar, W. H. M.; Glauner, T.; Wiesheu, R.; Kilbey, A.; Shaw, R.; Boufea, K.; Batada, N.; Blyth, K.; Miller, C.; Kirschner, K.; Coffelt, S. B.
10.1101/2021.07.04.451035 — immunology — Posted on 2021-07-04
3586 Neuronal activity drives pathway-specific depolarization of astrocyte distal processes
Armbruster, M.; Naskar, S.; Garcia, J.; Sommer, M.; Kim, E.; Adam, Y.; Haydon, P. G.; Boyden, E. S.; Cohen, A. E.; Dulla, C. G.
10.1101/2021.07.03.450922 — neuroscience — Posted on 2021-07-04
3587 Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer's disease
Guzman-Velez, E.; Diez, I.; Schoemaker, D.; Pardilla-Delgado, E.; Vila-Castelar, C.; Fox-Fuller, J. T.; Baena, A.; Sperling, R. A.; Johnson, K. A.; Lopera, F.; Sepulcre, J.; Quiroz, Y. T.
10.1101/2021.07.03.450933 — neuroscience — Posted on 2021-07-04
3592 Combined tumor and immune signals from genomes or transcriptomes predict outcomes of checkpoint inhibition in melanoma
Freeman, S. S.; Sade-Feldman, M.; Kim, J.; Stewart, C.; Gonye, A. L. K.; Ravi, A.; Arniella, M. B.; Gushterova, I.; LaSalle, T. J.; Blaum, E. M.; Yizhak, K.; Frederick, D. T.; Sharova, T.; Leshchiner, I.; Elagina, L.; Spiro, O. G.; Livitz, D.; Rosebrock, D.; Aguet, F.; Carrot-Zhang, J.; Ha, G.; Lin, Z.; Chen, J. H.; Barzily-Rokni, M.; Hammond, M. R.; Vitzthum von Eckstaedt, H. C.; Blackmon, S. M.; Jiao, Y. J.; Gabriel, S.; Lawrence, D. P.; Duncan, L. M.; Stemmer-Rachamimov, A. O.; Wargo, J. A.; Flaherty, K. T.; Sullivan, R. J.; Boland, G. M.; Meyerson, M.; Getz, G.; Hacohen, N.
10.1101/2021.07.03.450733 — genomics — Posted on 2021-07-04
3596 Lattice defects induced by microtubule-stabilizing agents exert a long-range effect on microtubule growth by promoting catastrophes
Rai, A.; Liu, T.; Katrukha, E. A.; Estevez-Gallego, J.; Paterson, I.; Diaz, F.; Kapitein, L. C.; Moores, C. A.; Akhmanova, A.
10.1101/2021.02.11.430743 — cell biology — Posted on 2021-07-04
3597 Three-dimensional drug screen identifies HDAC inhibitors as therapeutic agents in mTORC1-driven lymphangioleiomyomatosis
Pietrobon, A.; Yockell-Lelievre, J.; Melong, N.; Smith, L. J.; Delaney, S. P.; Azzam, N.; Xue, C.; Merwin, N.; Lian, E.; Camacho-Magallanes, A.; Dore, C.; Musso, G.; Julian, L. M.; Kristof, A. S.; Tam, R. Y.; Berman, J. N.; Shoichet, M. S.; Stanford, W. L.
10.1101/2021.07.03.451004 — cell biology — Posted on 2021-07-04
3598 SARS-CoV-2 Nsp14 mediates the effects of viral infection on the host cell transcriptome
Zaffagni, M.; Harris, J. M.; Patop, I. L.; Pamudurti, N. R.; Nguyen, S.; Kadener, S.
10.1101/2021.07.02.450964 — molecular biology — Posted on 2021-07-04
3600 Enzymatic and structural characterization of HAD5, an essential phosphomannomutase of malaria parasites
Frasse, P. M.; Miller, J. J.; Soleimani, E.; Zhu, J.-S.; Jakeman, D. L.; Jez, J. M.; Goldberg, D. E.; Odom John, A. R.
10.1101/2021.07.03.451008 — microbiology — Posted on 2021-07-04
3601 Multivalency enhances the specificity of Fc-cytokine fusions
Orcutt-Jahns, B.; Emmel, P. C.; Snyder, E. M.; Posner, C.; Carlson, S. M.; Meyer, A. S.
10.1101/2021.07.03.451002 — immunology — Posted on 2021-07-04
3604 3D printed lung on a chip device with a stretchable nanofibrous membrane for modeling ventilator induced lung injury
Tas, S.; Rehnberg, E.; Bölükbas, D. A.; Beech, J. P.; Nasi Kazado, L.; Svenningsson, I.; Arvidsson, M.; Sandberg, A.; Dahlgren, K. A.; Edthofer, A.; Gustafsson, A.; Isaksson, H.; Wood, J. A.; Tegenfeldt, J. O.; Wagner, D. E.
10.1101/2021.07.02.450873 — bioengineering — Posted on 2021-07-04
3605 Historical climate change and megafaunal extinctions linked to genetic diversity declines in shorebirds
Tan, H. Z.; Jansen, J. J. F. J.; Allport, G. A.; Garg, K. M.; Chattopadhyay, B.; Irestedt, M.; Chilton, G.; Gwee, C. Y.; Rheindt, F. E.
10.1101/2021.07.02.450884 — evolutionary biology — Posted on 2021-07-04
3606 An executive center for the intake of liquids
Dempsey, B.; Sungeelee, S.; Bokiniec, P.; Chettouh, Z.; Diem, S.; Autran, S.; Harrell, E. R.; Poulet, J. F. A.; Birchmeier, C.; Carey, H.; Genovesio, A.; McMullan, S.; Goridis, C.; Fortin, G.; Brunet, J.-F.
10.1101/2021.07.02.450862 — neuroscience — Posted on 2021-07-04
3607 Using Progressive Context Encoders for Anomaly Detection in Digital Pathology Images
Gillard, R.; Gu, Q.; Meroueh, C.; Prodduturi, N.; Patil, S.; Flotte, T. J.; Hart, S. N.
10.1101/2021.07.02.450957 — pathology — Posted on 2021-07-04
3608 Single cell tools for WormBase
da Veiga Beltrame, E.; Arnaboldi, V.; Sternberg, P. W.
10.1101/2021.07.04.451030 — bioinformatics — Posted on 2021-07-04
3610 RNA modification mapping with JACUSA2
Piechotta, M.; Wang, Q.; Altmueller, J.; Dieterich, C.
10.1101/2021.07.02.450888 — bioinformatics — Posted on 2021-07-04
3613 A Novel Art of Electrocardiogram Assessment in Zebrafish for Cardiovascular Disease Studies and Drug Screening
Le, T.; Zhang, J.; Nguyen, A. H.; Trigo Torres, R. S.; Vo, K.; Dutt, N.; Lee, J.; Ding, Y.; Xu, X.; Lau, M. P. H.; Cao, H.
10.1101/2021.07.02.450921 — bioengineering — Posted on 2021-07-04
3615 A genome-wide association study of serum proteins reveals shared loci with common diseases
Gudjonsson, A.; Gudmundsdottir, V.; Axelsson, G. T.; Gudmundsson, E. F.; Jonsson, B. G.; Launer, L. J.; Lamb, J. R.; Jennings, L. L.; Aspelund, T.; Emilsson, V.; Gudnason, V.
10.1101/2021.07.02.450858 — genomics — Posted on 2021-07-04
3616 Systems Biology Analysis of Human Genomes Points to Key Pathways Conferring Spina Bifida Risk
Aguiar-Pulido, V.; Wolujewicz, P.; Martinez-Fundichely, A.; Elhaik, E.; Thareja, G.; Abdel-Aleem, A.; Chalhoub, N.; Cuykendall, T.; Al-Zamer, J.; Lei, Y.; El-Bashir, H.; Musser, J. M.; Al-Kaabi, A.; Shaw, G. M.; Khurana, E.; Suhre, K.; Mason, C.; Elemento, O.; Finnell, R. H.; Ross, M. E.
10.1101/2021.07.02.450913 — genomics — Posted on 2021-07-04
3617 Economic costs of biological invasions in the United States
Fantle-Lepczyk, J.; Haubrock, P. J.; Cuthbert, R. N.; Kramer, A. M.; Turbelin, A. J.; Crystal-Ornelas, R.; Diagne, C.; Courchamp, F.
10.1101/2021.07.02.450757 — ecology — Posted on 2021-07-04
3619 Single-domain antibodies for targeting, detection and in vivo imaging of human CD4+ cells
Traenkle, B.; Kaiser, P. D.; Pezzana, S.; Richardson, J.; Gramlich, M.; Wagner, T. R.; Weldle, M.; Holz, S.; Parfyonova, Y.; Schaller, M.; Nueske, S.; Scholz, A.; Zeck, A.; Jakobi, M.; Schneiderhan-Marra, N.; Maurer, A.; Gouttefangeas, C.; Kneilling, M.; Pichler, B. J.; Sonanini, D.; Rothbauer, U.
10.1101/2021.07.02.450848 — immunology — Posted on 2021-07-04
3620 Single nucleus transcriptomic analysis of human dorsal root ganglion neurons
Nguyen, M. Q.; von Buchholtz, L. J.; Reker, A. N.; Ryba, N. J. P.; Davidson, S.
10.1101/2021.07.02.450845 — neuroscience — Posted on 2021-07-04
3624 A multimodal AI system for out-of-distribution generalization of seizure detection
Yang, Y.; Truong, N. D.; Eshraghian, J. K.; Maher, C.; Nikpour, A.; Kavehei, O.
10.1101/2021.07.02.450974 — neuroscience — Posted on 2021-07-04
3629 Making BrainWaves: Portable Brain Technologies in Biology Education
Davidesco, I.; Azeka, S.; Carter, S.; Laurent, E.; Valk, H.; Naipaul, J.; Dikker, S.; Suzuki, W. A.
10.1101/2021.07.02.450935 — scientific communication and education — Posted on 2021-07-04
3630 Fatty acid binding proteins shape the cellular response to activation of the glucocorticoid receptor
Liu, B.; Chandrashekaran, I. R.; Ilyichova, O.; Valour, D.; Melchiore, F.; Bourrier, C.; Giganti, A.; Stephan, J.-P.; Dacquet, C.; Genissel, P.; Gosgnach, W.; Weaver, R. J.; Porter, C. J.; Scanlon, M. J.; Halls, M. L.
10.1101/2021.07.02.450968 — pharmacology and toxicology — Posted on 2021-07-04
3631 The first observation of osmotically neutral sodium accumulation in the myocardial interstitium
Artyukov, I.; Arutyunov, G.; Bobrov, M. A.; Bukreeva, I.; Cedola, A.; Dragunov, D.; Feshchenko, R.; Fratini, M.; Mitrokhin, V. M.; Sokolova, A. V.; Vinogradov, A.; Gianoncelli, A.
10.1101/2021.07.02.450864 — biophysics — Posted on 2021-07-04
3632 Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket - Targeting P-pocket by fragment screening
Singh, A. K.; Martinez, S. E.; Gu, W.; Nguyen, H.; Schols, D.; Herdewijn, P. H.; De Jonghe, S.; Das, K.
10.1101/2021.07.03.451029 — biophysics — Posted on 2021-07-04
3637 Repopulation of a 3D-simulated periapical lesion cavity with triggered osteoblastic-differentiated dental pulp stem cell spheroids.
Ribeiro, V. L.; Dernowsek, J. A.; Fernandes, R. R.; Pitol, D.; Issa, J. P.; Chaves, J.; Bombonato-Prado, K. F.; Sousa-Neto, M. D.; Passos, G. A.
10.1101/2021.07.02.450930 — bioengineering — Posted on 2021-07-04
3638 Extrachromosomal DNA is associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma
Zhao, X.; Xing, P.; Song, X.; Zhao, M.; Zhao, L.; Dang, Y.; Lei, L.-L.; Xu, R.-H.; Han, W.-L.; Wang, P.-P.; Yang, M.-M.; Hu, J.-F.; Zhong, K.; Zhou, F.-Y.; Han, X.-N.; Meng, C.-L.; Ji, J.-J.; Chen, X.; Wang, L.-D.
10.1101/2021.07.02.450861 — genomics — Posted on 2021-07-04
3639 Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection
Brugger, M.; Demoulins, T.; Barut, G. T.; Zumkehr, B.; Oliveira Esteves, B.; Mehinagic, K.; Haas, Q.; Schogler, A.; Rameix-Welti, M.-A.; Eleouet, J.-F.; Moehrlen, U.; Marti, T.; Schmid, R.; Summerfield, A.; Posthaus, H.; Ruggli, N.; Hall, S.; Alves, M. P.
10.1101/2021.05.12.443770 — microbiology — Posted on 2021-07-04
3641 Structural basis for the specificity of PPM1H phosphatase for Rab GTPases
Waschbüsch, D.; Berndsen, K.; Lis, P.; Knebel, A.; Lam, Y. P.; Alessi, D. R.; Khan, A. R.
10.1101/2021.02.17.431620 — biochemistry — Posted on 2021-07-04
3645 VPRBP functions downstream of the androgen receptor and OGT to restrict p53 activation in prostate cancer
Poulose, N.; Polonski, A.; Forsythe, N.; Gregg, G.; Maguire, S.; Fuchs, M.; Minner, S.; McDade, S. S.; Mills, I.
10.1101/2021.02.28.433236 — cancer biology — Posted on 2021-07-04
3646 Single caudate neurons encode temporally discounted value for formulating motivation for action
Hori, Y.; Mimura, K.; Nagai, Y.; Fujimoto, A.; Oyama, K.; Kikuchi, E.; Inoue, K.-i.; Takada, M.; Suhara, T.; Richmond, B. J.; Minamimoto, T.
10.1101/2020.05.18.101824 — neuroscience — Posted on 2021-07-04
3648 Combinatorial Polyacrylamide Hydrogels for Preventing Biofouling on Implantable Biosensors
Chan, D.; Chien, J.-C.; Axpe, E.; Blankemeier, L.; Baker, S. W.; Swaminathan, S.; Piunova, V. A.; Zubarev, D. Y.; Maikawa, C. L.; Grosskopf, A. K.; Mann, J. L.; Soh, H. T.; Appel, E. A.
10.1101/2020.05.25.115675 — bioengineering — Posted on 2021-07-04
3649 Tfap2b specifies an embryonic melanocyte stem cell population that retains adult multi-fate potential
Brombin, A.; Simpson, D. J.; Travnickova, J.; Brunsdon, H. R.; Zeng, Z.; Lu, Y.; Chandra, T.; Patton, E. E.
10.1101/2021.06.18.448859 — developmental biology — Posted on 2021-07-04
3657 Parallel processing in speech perception: Local and global representations of linguistic context
Brodbeck, C.; Bhattasali, S.; Cruz Heredia, A. A. L.; Resnik, P.; Simon, J. Z.; Lau, E.
10.1101/2021.07.03.450698 — neuroscience — Posted on 2021-07-03
3658 Deep learning and cross-species analysis identify the influences of sex and cannabinoidsignaling on cerebellar vermis morphology
Black, K. C.; McPherson, B. C.; Hainline, J.; Baygani, S.; Webb, B.; Mier, T. J.; Essex, A.; Mackie, K.; Pestilli, F.; Kalinovsky, A.
10.1101/2021.07.03.450642 — neuroscience — Posted on 2021-07-03
3659 The role of feedback in the production of skilled finger sequences
Popp, N. J.; Hernandez-Castillo, C. R.; Gribble, P. L.; Diedrichsen, J.
10.1101/2021.07.02.450916 — neuroscience — Posted on 2021-07-03
3660 Music-Based Intervention Connects Auditory and Reward Systems
Quinci, M.; Belden, A.; Goutama, V.; Gong, D.; Hanser, S.; Donovan, N. J.; Geddes, M.; Loui, P.
10.1101/2021.07.02.450867 — neuroscience — Posted on 2021-07-03
3661 mGluR5 Negative Modulators for Fragile X: Resistance and Persistence
Stoppel, D. C.; McCamphill, P. K.; Senter, R. K.; Heynen, A. J.; Bear, M. F.
10.1101/2021.07.02.450894 — neuroscience — Posted on 2021-07-03
3662 Hyperdirect connectivity of opercular speech network to the subthalamic nucleus
Jorge, A.; Lipksi, W. J.; Wang, D.; Crammond, D. J.; Turner, R. S.; Richardson, R. M.
10.1101/2021.07.02.450909 — neuroscience — Posted on 2021-07-04
3665 Decay and damage of therapeutic phage OMKO1 by environmental stressors
Blazanin, M.; Lam, W. T.; Vasen, E.; Chan, B. K.; Turner, P.
10.1101/864025 — microbiology — Posted on 2021-07-03
3666 Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder
Westacott, L. J.; Humby, T.; Naan, N.; Brain, S. A.; Bush, E.-L.; Toneva, M.; Baloc, A.-I.; Moon, A. L.; Reddaway, J.; Owen, M. J.; Hall, J.; Hughes, T. R.; Morgan, B. P.; Gray, W. P.; Wilkinson, L.
10.1101/685537 — neuroscience — Posted on 2021-07-03
3668 Entorhinal cortex EWAS meta-analysis highlights four novel loci showing differential methylation in Alzheimer's disease
Sommerer, Y.; Dobricic, V.; Schilling, M.; Ohlei, O.; Sabet, S. S.; Wesse, T.; Fuss, J.; Franzenburg, S.; Franke, A.; Parkkinen, L.; Lill, C. M.; Bertram, L.
10.1101/2021.07.02.450878 — genomics — Posted on 2021-07-03
3671 The blood vasculature instructs lymphatics patterning in a SOX7-dependent manner
Chiang, I. K. N.; Luu, W.; Jiang, K.; Kirschnick, N.; Moustaqil, M.; Davidson, T. L.; Lesieur, E.; Skoczylas, R.; Kouskoff, V.; Kazenwadel, J.; Arriola-Martinez, L.; Sierecki, E.; Gambin, Y.; Alitalo, K.; Kiefer, F.; Harvey, N. L.; Francois, M.
10.1101/2021.07.02.450967 — developmental biology — Posted on 2021-07-03
3672 ERp44 is Required for Endocardial Cushion Development by Regulating VEGFA Secretion in Myocardium
Bi, Y.; Yang, Z.; Jin, M.; Zhai, K.; Wang, J.; Mao, Y.; Liu, Y.; Ding, M.; Wang, H.; Wang, F.; Ji, G.
10.1101/2021.07.02.450976 — developmental biology — Posted on 2021-07-03
3674 Mammalian UPF3A and UPF3B activate NMD independently of their EJC binding
Yi, Z.; Arvola, R. M.; Myers, S.; Dilsavor, C. N.; Abu Alhasan, R.; Carter, B. N.; Patton, R. D.; Bundschuh, R.; Singh, G.
10.1101/2021.07.02.450872 — molecular biology — Posted on 2021-07-03
3675 Manual resolution of virome dark matter uncovers hundreds of viral families in the infant gut
Shah, S. A.; Deng, L.; Thorsen, J.; Pedersen, A. G.; Dion, M. B.; Castro Mejia, J.; Silins, R.; Romme, F. O.; Sausset, R.; Ndela, E. O.; Hjemso, M. H.; Rasmussen, M. A. A.; Redgwell, T.; Vestergaard, G. A.; Zhang, Y.; Enault, F.; Sorensen, S. J.; Bisgaard, H.; Stokholm, J.; Moineau, S.; Petit, M.-A.; Nielsen, D. S.
10.1101/2021.07.02.450849 — microbiology — Posted on 2021-07-03
3676 Identification of effector metabolites using exometabolite profiling of diverse microalgae
Brisson, V.; Mayali, X.; Bowen, B.; Golini, A.; Thelen, M. P.; Stuart, R. K.; Northen, T.
10.1101/2021.07.02.450979 — microbiology — Posted on 2021-07-03
3677 Plasmodium falciparum GBP2 is a telomere-associated protein that binds to G-quadruplex DNA and RNA
Edwards-Smallbone, J.; Jensen, A. L.; Roberts, L. E.; Totanes, F. I. G.; Hart, S. R.; Merrick, C. J.
10.1101/2021.07.02.450898 — microbiology — Posted on 2021-07-03
3678 Kinetic Properties of Microbial Exoenzymes Vary with Soil Depth but Have Similar Temperature Sensitivities Through the Soil Profile
Alves, R. J. E.; Callejas, I. A.; Marschmann, G. L.; Mooshammer, M.; Singh, H. W.; Whitney, B.; Torn, M. S.; Brodie, E. L.
10.1101/2021.07.02.450965 — microbiology — Posted on 2021-07-03
3682 Pharmacokinetics and Central Accumulation of Delta-9-Tetrahydrocannabinol (THC) and its Bioactive Metabolites are Influenced by Route of Administration and Sex
Baglot, S. L.; Hume, C.; Petrie, G. N.; Aukema, R. J.; Lightfoot, S. H.; Grace, L. M.; Zhou, R.; Parker, L.; Rho, J. M.; Borgland, S. L.; McLaughlin, R. J.; Brechenmacher, L.; Hill, M. N.
10.1101/2021.07.02.450963 — neuroscience — Posted on 2021-07-03
3683 The MAP3Ks DLK and LZK direct diverse responses to axon damage in zebrafish peripheral neurons
Adula, K. P.; Shorey, M.; Chauhan, V.; Nassman, K.; Chen, S.-F.; Rolls, M.; Sagasti, A.
10.1101/2021.07.03.450951 — neuroscience — Posted on 2021-07-03
3685 Monitoring the 5`UTR landscape reveals 5`terminal oligopyrimidine (TOP) motif switches to drive translational efficiencies
Weber, R.; Ghoshdastider, U.; Spies, D.; Dure, C.; Valdivia-Francia, F.; Forny, M.; Ormiston, M.; Renz, P. F.; Taborsky, D.; Yigit, M.; Yamahachi, H.; Sendoel, A.
10.1101/2021.07.02.450886 — cancer biology — Posted on 2021-07-03
3686 Truncation of IFT80 causes early embryonic loss in cattle
Obando Ortega, M. S.; Bickhart, D. M.; Clark, K. N.; Null, D. J.; Hutchison, J. L.; McClure, J. C.; Cole, J. B.
10.1101/2021.07.02.450952 — genomics — Posted on 2021-07-03
3688 ENDO-Pore: High-throughput linked-end mapping of single DNA cleavage events using nanopore sequencing
Torres Montaguth, O. E.; Cross, S. J.; Ingram, K. W. A.; Lee, L.; Diffin, F. M.; Szczelkun, M.
10.1101/2021.07.02.450912 — molecular biology — Posted on 2021-07-03
3690 A Population-level Strain Genotyping Method to Study Pathogen Strain Dynamics in Human Infections
Morgan, S. J.; Durfey, S. L.; Ravishankar, S.; Jorth, P.; Ni, W.; Skerrett, D.; Aitken, M. L.; Mckone, E. F.; Salipante, S.; Radey, M.; Singh, P. K.
10.1101/2021.07.02.450905 — microbiology — Posted on 2021-07-03
3691 Plakoglobin and HMGB1 mediate intestinal epithelial cell apoptosis induced by Clostridioides difficile TcdB
Li, Y.; Xu, W.; Ren, Y.; Cheung, H.-C.; Huang, P.; Kaur, G.; Kuo, C.-J.; McDonough, S. P.; Fubini, S. L.; Lipkin, S. M.; Deng, X.; Chang, Y.-F.; Huang, L.
10.1101/2021.07.02.450318 — microbiology — Posted on 2021-07-03
3693 Mitochondrial dysfunction triggers secretion of the immunosuppressive factor α-fetoprotein
Jett, K. A.; Baker, Z. N.; Hossain, A.; Boulet, A.; Cobine, P. A.; Ghosh, S.; Ng, P.; Yilmaz, O.; Barretto, K.; DeCoteau, J.; Mochoruk, K.; Ioannou, G.; Savard, C.; Yuan, S.; Lowden, C.; Kim, B.-E.; Cheng, H.-Y. M.; Battersby, B. J.; Gohil, V. M. M.; Leary, S. C.
10.1101/2021.07.02.450924 — cell biology — Posted on 2021-07-03
3694 Dasabuvir inhibits human norovirus infection in human intestinal enteroids
Hayashi, T.; Murakami, K.; Hirano, J.; Fujii, Y.; Yamaoka, Y.; Ohashi, H.; Watashi, K.; Estes, M. K.; Muramatsu, M.
10.1101/2021.07.02.450857 — microbiology — Posted on 2021-07-03
3695 The pore conformation of lymphocyte perforin
Ivanova, M.; Lukoyanova, N.; Malhotra, S.; Topf, M.; Trapani, J. A.; Voskoboinik, I.; Saibil, H. R.
10.1101/2021.07.03.450947 — biochemistry — Posted on 2021-07-03
3696 Accurately positioning functional residues with robotics-inspired computational protein design
Krivacic, C.; Kundert, K.; Pan, X.; Pache, R. A.; Liu, L.; O Conchuir, S.; Jeliazkov, J. R.; Gray, J. J.; Thompson, M. C.; Fraser, J. S.; Kortemme, T.
10.1101/2021.07.02.450934 — bioengineering — Posted on 2021-07-03
3697 Benchmarking ideal sample thickness in cryo-EM using MicroED
Martynowycz, M. W.; Clabbers, M. T. B.; Unge, J.; Hattne, J.; Gonen, T.
10.1101/2021.07.02.450941 — biochemistry — Posted on 2021-07-03
3700 Protein abundance and folding rather than the redox state of Kelch13 determine the artemisinin susceptibility of Plasmodium falciparum
Schumann, R.; Bischoff, E.; Klaus, S.; Möhring, S.; Flock, J.; Keller, S.; Remans, K.; Ganter, M.; Deponte, M.
10.1101/2021.07.02.450839 — biochemistry — Posted on 2021-07-03
3702 Dissociation of β2m from MHC Class I Triggers Formation of Noncovalent, Transient Heavy Chain Dimers
Dirscherl, C.; Loechte, S.; Hein, Z.; Kopicki, J.-D.; Harders, A. R.; Linden, N.; Weghuber, J.; Garcia-Alai, M.; Uetrecht, C.; Zacharias, M.; Piehler, J.; Lanzerstorfer, P.; Springer, S.
10.1101/2021.07.02.450866 — cell biology — Posted on 2021-07-03
3705 Integrated light and electron microscopy continuum resolution imaging of 3D cell cultures
Dimprima, E.; Garcia Montero, M.; Gawrzak, S.; Ronchi, P.; Zagoriy, I.; Schwab, Y.; Jechlinger, M.; Mahamid, J.
10.1101/2021.07.02.450855 — cell biology — Posted on 2021-07-03
3708 Allergy-induced systemic inflammation impairs tendon quality
Lehner, C.; Spitzer, G.; Langthaler, P.; Jakubecova, D.; Klein, B.; Weissenbacher, N.; Wagner, A.; Gehwolf, R.; Trinka, E.; Iglseder, B.; Paulweber, B.; Aigner, L.; Couillard-Despres, S.; Weiss, R.; Tempfer, H.; Traweger, A.
10.1101/2021.07.02.450910 — molecular biology — Posted on 2021-07-03
3710 Co-deletion of ATAD1 with PTEN primes cells for BIM-mediated apoptosis
Winter, J. M.; Fresenius, H. L.; Keys, H. R.; Cunningham, C. N.; Ryan, J.; Sirohi, D.; Berg, J. A.; Tripp, S. R.; Barta, P.; Agarwal, N.; Letai, A.; Sabatini, D. M.; Wohlever, M. L.; Rutter, J.
10.1101/2021.07.01.450781 — cancer biology — Posted on 2021-07-03
3711 Blockade of pro-fibrotic response mediated by the miR-143/-145 cluster prevents targeted therapy-induced phenotypic plasticity and resistance in melanoma
Diazzi, S.; Baeri, A.; Fassy, J.; Lecacheur, M.; Marin-Bejar, O.; Girard, C.; Lefevre, L.; Lacoux, C.; Irondelle, M.; Mounier, C.; Truchi, M.; Couralet, M.; Carminati, A.; Berestjuk, I.; Larbret, F.; Vassaux, G.; Marine, J.-C.; Deckert, M.; Mari, B.; Tartare-Deckert, S.
10.1101/2021.07.02.450838 — cancer biology — Posted on 2021-07-03
3712 Deep learning-based quantification of arbuscular mycorrhizal fungi in plant roots
Evangelisti, E.; Turner, C.; McDowell, A.; Shenhav, L.; Yunusov, T.; Gavrin, A.; Servante, E. K.; Quan, C.; Schornack, S.
10.1101/2021.03.05.434067 — plant biology — Posted on 2021-07-03
3713 Correlated Evolution in the Small Parsimony Framework
Smith, B.; Navarro-Martinez, C.; Buonopane, R.; Byun, A. S.; Patterson, M. D.
10.1101/2021.01.26.428213 — evolutionary biology — Posted on 2021-07-03
3717 Glucose-dependent miR-125b is a negative regulator of β-cell function
Cheung, R. W. S.; Pizza, G.; Chabosseau, P.; Rolando, D.; Tomas, A.; Burgoyne, T.; Salowka, A.; Macklin, A.; Cao, Y.; Nguyen-Tu, M.-S.; Marchetti, P.; Shapiro, J.; Piemonti, L.; de Koning, E. J. P.; Leclerc, I.; Sakamoto, K.; Smith, D. M.; Rutter, G. A.; Martinez-sanchez, A.
10.1101/2021.05.17.444559 — molecular biology — Posted on 2021-07-03
3720 A centronuclear myopathy-causing mutation in dynamin-2 perturbs the actin-dependent structure of dendritic spines leading to excitatory synaptic defects in a murine model of the disease
ARRIAGADA-DIAZ, J.; Gomez, B.; Prado-Vega, L.; MATTAR-ARAOS, M.; LABRANA-ALLENDE, M.; HINOSTROZA, F.; Gajardo, I.; Guerra-Fernandez, M. J.; Bevilacqua, J. A.; CARDENAS, A. M.; Bitoun, M.; ARDILES, A. O.; GONZALEZ-JAMETT, A. M.
10.1101/2021.06.28.450172 — neuroscience — Posted on 2021-07-03
3723 Structural connectome quantifies tumor invasion and predicts survival in glioblastoma patients
Wei, Y.; Li, C.; Cui, Z.; Mayrand, R. C.; Zou, J.; Wong, A. L. K. C.; Sinha, R.; Matys, T.; Schönlieb, C.-B.; Price, S. J.
10.1101/2021.03.09.434656 — neuroscience — Posted on 2021-07-03
3725 The Phtheirospermum japonicum isopentenyltransferase PjIPT1a regulates host cytokinin responses in Arabidopsis
Greifenhagen, A.; Braunstein, I.; Pfannstiel, J.; Yoshida, S.; Shirasu, K.; Schaller, A.; Spallek, T.
10.1101/2021.05.24.445531 — plant biology — Posted on 2021-07-03
3726 Gasdermin D mediates inflammation-induced defects in reverse cholesterol transport and promotes atherosclerosis.
Opoku, E.; Traughber, C. A.; Zhang, D.; Iacano, A. J.; Khan, M.; Han, J.; Smith, J. D.; Gulshan, K.
10.1101/2021.04.16.440183 — pathology — Posted on 2021-07-03
3728 KOMB: Graph-Based Characterization of Genome Dynamics in Microbial Communities
Balaji, A.; Sapoval, N.; Seto, C.; Elworth, R. A. L.; Nute, M. G.; Savidge, T.; Segarra, S.; Treangen, T. J.
10.1101/2020.05.21.109587 — bioinformatics — Posted on 2021-07-03
3731 Permutation-based significance analysis reduces the type 1 error rate in bisulfite sequencing data analysis of human umbilical cord blood samples
Laajala, E.; Halla-aho, V.; Grönroos, T.; Ullah, U.; Vähä-Mäkilä, M.; Nurmio, M.; Kallionpää, H.; Lietzen, N.; Mykkänen, J.; Rasool, O.; Toppari, J.; Oresic, M.; Knip, M.; Lund, R. J.; Lahesmaa, R.; Lähdesmäki, H.
10.1101/2021.05.18.444359 — bioinformatics — Posted on 2021-07-03
3732 Enhancing the interoperability of glycan data flow between ChEBI, PubChem, and GlyGen.
Navelkar, R.; Owen, G.; Mutherkrishnan, V.; Thiessen, P.; Bolton, E.; Cheng, T.; Edwards, N.; Tiemeyer, M.; Campbell, M.; Martin, M.; Vora, J.; Kahsay, R.; Mazumder, R.
10.1101/2021.06.17.448729 — bioinformatics — Posted on 2021-07-03
3733 Suppression of sost/sclerostin and dickkopf-1 promote intervertebral disc structure in mice
Kroon, T. M.; Niziolek, P.; Edwards, D.; Clinkenbeard, E. L.; Robling, A. G.; Holguin, N.
10.1101/2021.07.01.449486 — bioengineering — Posted on 2021-07-03
3736 Convergent consequences of parthenogenesis on stick insect genomes
Jaron, K. S.; Parker, D. J.; Anselmetti, Y.; Tran Van, P.; Bast, J.; Dumas, Z.; Figuet, E.; Francois, C. M.; Hayward, K.; Rossier, V.; Simion, P.; Robinson-Rechavi, M.; Galtier, N.; Schwander, T.
10.1101/2020.11.20.391540 — evolutionary biology — Posted on 2021-07-03
3737 Environmental transmission of Pseudogymnoascus destructans to hibernating little brown bats
Hicks, A. C.; Darling, S.; Flewelling, J.; von Linden, R.; Meteyer, C. U.; Redell, D.; White, J. P.; Redell, J.; Smith, R.; Blehert, D.; Rayman, N.; Hoyt, J. R.; Okoniewski, J. C.; Langwig, K. E.
10.1101/2021.07.01.450774 — ecology — Posted on 2021-07-03
3740 The evolutionary origins of extreme halophilic Archaea
Feng, Y.; Neri, U.; Gosselin, S.; Louyakis, A. S.; Papke, R. T.; Gophna, U.; Gogarten, J. P.
10.1101/2019.12.19.883488 — microbiology — Posted on 2021-07-03
3741 Combined protein and transcript single cell RNA sequencing in human peripheral blood mononuclear cells
Vallejo, J.; Saigusa, R.; Gulati, R.; Ghosheh, Y.; Durant, C. P.; Roy, P.; Ehinger, E.; Pattarabanjird, T.; Padgett, L. E.; Olingy, C. E.; Hanna, D. B.; Landay, A. L.; Tracy, R. P.; Lazar, J. M.; Mack, W. J.; Weber, K. M.; Adimora, A. A.; Hodis, H. N.; Tien, P. C.; Ofotokun, I.; Heath, S. L.; Dinh, H. Q.; Shemesh, A.; McNamara, C. A.; Lanier, L. L.; Hedrick, C. C.; Kaplan, R. C.; Ley, K.
10.1101/2020.09.10.292086 — immunology — Posted on 2021-07-03
3748 The spatial transcriptomic landscape of the healing intestine following damage
Parigi, S. M.; Larsson, L.; Das, S.; Ramirez Flores, R. O.; Frede, A.; Tripathi, K.; Diaz, O.; Selin, K.; Morales, R. A.; Luo, X.; Monasterio, G.; Engblom, C.; Gagliani, N.; Saez, J.; Lundeberg, J.; Villablanca, E. J.
10.1101/2021.07.01.450768 — systems biology — Posted on 2021-07-03
3751 Knowledge-based antibody repertoire simulation, a novel allele detection tool evaluation and application
Yang, X.; Zhu, Y.; Zeng, H.; Chen, S.; Guan, J.; Wang, Q.-L.; Lan, C.; Sun, D.; Yu, X.; Zhang, Z.
10.1101/2021.07.01.450681 — bioinformatics — Posted on 2021-07-02
3756 OpenSense: An open-source toolbox for Inertial-Measurement-Unit-based measurement of lower extremity kinematics over long durations
Al Borno, M.; O'Day, J.; Ibarra, V.; Dunne, J.; Seth, A.; Habib, A.; Ong, C.; Hicks, J.; Uhlrich, S.; Delp, S.
10.1101/2021.07.01.450788 — bioengineering — Posted on 2021-07-02
3757 On the contingent nature of satellite DNA evolution
Camacho, J. P. M.; Cabrero, J.; Lopez-Leon, M. D.; Martin-Pecina, M.; Perfectti, F.; Garrido-Ramos, M. A.; Ruiz-Ruano, F. J.
10.1101/2021.07.01.450629 — genomics — Posted on 2021-07-03
3763 Aboveground biomass increments over 26 years (1993-2019) in an old-growth cool-temperate forest in northern Japan
Noguchi, M.; Hoshizaki, K.; Matsushita, M.; Sugiura, D.; Yagihashi, T.; Saitoh, T.; Itabashi, T.; Kazuhide, O.; Shibata, M.; Hoshino, D.; Masaki, T.; Osumi, K.; Takahashi, K.; Suzuki, W.
10.1101/2021.07.02.450668 — ecology — Posted on 2021-07-02
3766 Neutrophil and natural killer cell imbalances prevent muscle stem cell mediated regeneration following murine volumetric muscle loss
Larouche, J. A.; Kurpiers, S. J.; Yang, B. A.; Davis, C.; Fraczek, P. M.; Hall, M.; Brooks, S. V.; Shea, L. D.; Aguilar, C. A.
10.1101/2021.07.02.450777 — cell biology — Posted on 2021-07-02
3767 Clonal dynamics of normal hepatocyte expansions in homeostatic human livers and their association with the biliary epithelium
Passman, A.; Haughey, M. J.; Carlotti, E.; Williams, M. J.; Cereser, B. J.; Lin, M.-L.; Devkumar, S.; Gabriel, J. p.; Russo, F. P.; Hoare, M.; Jansen, M.; Chin-Aleong, J.; Wright, N. A.; Kocher, H.; Huang, W.; Alison, M. R.; McDonald, S. A.
10.1101/2021.07.02.450704 — cell biology — Posted on 2021-07-02
3768 Mapping Protein Numbers in Living Cells
Thirstrup, D. J.; Yao, J.; Sherman, J.; Mueller, I. A.; Wiegraebe, W.
10.1101/2021.07.02.450806 — cell biology — Posted on 2021-07-03
3773 Network diffusion model predicts neurodegeneration in limb-onset amyotrophic lateral sclerosis
Bhattarai, A.; Chen, Z.; Chua, P.; Talman, P.; Mathers, S.; Chapman, C.; Howe, J.; Lee, C. S.; Lie, Y.; Poudel, G. R.; Egan, G. F.
10.1101/2021.07.02.450445 — neuroscience — Posted on 2021-07-02
3774 Postsynaptic plasticity of cholinergic synapses underlies the induction and expression of appetitive memories in Drosophila
Pribbenow, C.; Chen, Y.-c.; Heim, M.-M.; Laber, D.; Reubold, S.; Reynolds, E.; Balles, I.; Suarez Grimalt, R.; Rauch, C.; Roesner, J.; Fernandez-d.V. Alquicira, T.; Owald, D.
10.1101/2021.07.01.450776 — neuroscience — Posted on 2021-07-02
3776 A validation standard for Area of Habitat maps for terrestrial birds and mammals
Dahal, P. R.; Lumbierres, M.; Butchart, S. H. M.; Donald, P. F.; Rondinini, C.
10.1101/2021.07.02.450824 — zoology — Posted on 2021-07-02
3778 PEPSDI: Scalable and flexible inference framework for stochastic dynamic single-cell models
Persson, S.; Welkenhuysen, N.; Shashkova, S.; Wiqvist, S.; Reith, P.; Schmidt, G. W.; Picchini, U.; Cvijovic, M.
10.1101/2021.07.01.450748 — systems biology — Posted on 2021-07-02
3782 Time to recover from daily caffeine intake.
Lin, Y.-S.; Weibel, J.; Landolt, H.-P.; Santini, F.; Garbazza, C.; Kistler, J.; Rehm, S. S.; Rentsch, K.; Borgwardt, S.; Cajochen, C.; Reichert, C.
10.1101/2021.07.01.450708 — pharmacology and toxicology — Posted on 2021-07-02
3783 The Effect of a Fennel Extract on the STAT Signaling and Intestinal Barrier Function
Rabalais, J.; Kozan, P.; Lu, T.; Durali, N.; Okamoto, K.; Das, B.; McGeough, M. D.; Lee, J. B.; Barrett, K. E.; Marchelletta, R.; Sivagnanam, M.
10.1101/2021.07.01.450766 — pharmacology and toxicology — Posted on 2021-07-02
3784 Sulfated polysaccharides from red seaweed Gracilaria cornea induce macrophages polarization to an antitumor M1 phenotype
Teles, F. B.; Assef, A. N. B.; Andrade, R. M.; Soares, V. V. M.; Alves, A. W. d. S.; Lima-Junior, R. C. P.; Benevides, N. M. B.; Wilke, D. V.
10.1101/2021.07.01.450714 — pharmacology and toxicology — Posted on 2021-07-02
3786 SPOROS: A pipeline to analyze DISE/6mer seed toxicity
Bartom, E.; Kocherginsky, M.; Paudel, B.; Vaidyanathan, A.; Haluck-Kangas, A.; Patel, M.; O'Shea, K.; Murmann, A.; Peter, M. E.
10.1101/2021.07.01.450720 — bioinformatics — Posted on 2021-07-02
3788 Mining all publicly available expression data to compute dynamic microbial transcriptional regulatory networks
Sastry, A. V.; Poudel, S.; Rychel, K.; Yoo, R.; Lamoureux, C. R.; Chauhan, S.; Haiman, Z. B.; Al Bulushi, T.; Seif, Y.; Palsson, B. O.
10.1101/2021.07.01.450581 — bioinformatics — Posted on 2021-07-02
3790 Temporal Gene Expression in Apical Culms Shows Early Changes in Cell Wall Biosynthesis Genes in Sugarcane
Hosaka, G. K.; Correr, F. H.; Silva, C. C.; Sforca, D. A.; Zatti Barreto, F.; Almeira Balsalobre, T. W.; Pasha, A.; de Souza, A. P.; Provart, N. J.; Carneiro, M. S.; Margarido, G. R. A.
10.1101/2021.07.01.450585 — genomics — Posted on 2021-07-02
3791 An Automated SNP-Based Approach for Contaminant Identification in Biparental Polyploid Populations of Tropical Forage Grasses
Martins, F. B.; Moraes, A. d. C. L.; Aono, A. H.; Ferreira, R. C. U.; Chiari, L.; Simeao, R. M.; Barrios, S. C. L.; Santos, M. F.; Jank, L.; do Valle, C. B.; Vigna, B.; de Souza, A. P.
10.1101/2021.07.01.450796 — genomics — Posted on 2021-07-02
3797 Knockout of Anopheles stephensi immune gene LRIM1 by CRISPR-Cas9 reveals its unexpected role in reproduction and vector competence
Inbar, E.; Eappen, A.; Alford, R. T.; Reid, W.; Harrell, R. A.; Hosseini, M.; Chakravarty, S.; Li, T.; Sim, B. K. L.; Billingsley, P. F.; Hoffman, S. L.
10.1101/2021.07.02.450840 — microbiology — Posted on 2021-07-02
3798 Behavioral origin of sound-evoked activity in visual cortex
Bimbard, C.; Sit, T. P.; Lebedeva, A.; Harris, K. D.; Carandini, M.
10.1101/2021.07.01.450721 — neuroscience — Posted on 2021-07-02
3800 Atypical gaze patterns in autism are heterogeneous across subjects but reliable within individuals
Keles, U.; Kliemann, D.; Byrge, L.; Saarimaki, H.; Paul, L. K.; Kennedy, D. P.; Adolphs, R.
10.1101/2021.07.01.450793 — neuroscience — Posted on 2021-07-02
3801 Living with high potassium: an asset or a hindrance
Pantha, P.; Oh, D.-H.; Longstreth, D. J.; Dassanayake, M.
10.1101/2021.07.01.450778 — plant biology — Posted on 2021-07-02
3802 Large-scale topological disruption of chromosome territories 9 and 22 is associated with nonresponse to treatment in CML
Fabian-Morales, E.; Vallejo Escamilla, D. G.; Gomez, A. A. G.; Rodriguez, A.; Gonzalez-Barrios, R.; Rodriguez-Torres, Y. L.; Henandez, C. C.; de la Torre Lujan, A.; Rico, D. A. O.; Guzman, E. C. O.; Saavedra, A. L.; Frias, S.; Montalvo, L. A. H.
10.1101/2021.07.01.450740 — cancer biology — Posted on 2021-07-02
3803 High confidence identification of intra-host single nucleotide variants for person-to-person influenza transmission tracking in congregate settings
Maljkovic Berry, I.; Treangen, T.; Fung, C.; Tai, S.; Pollett, S.; Hong, F.; Li, T.; Pireku, P.; Thomanna, A.; German, J.; Bueno de Mesquita, P. J.; Rutvisuttinunt, W.; Panciera, M.; Lidl, G.; Frieman, M.; Jarman, R. G.; Milton, D. K.
10.1101/2021.07.01.450528 — genomics — Posted on 2021-07-02
3806 Accurate profiling of forensic autosomal STRs using the Oxford Nanopore Technologies MinION device
Hall, C. L.; Kesharwani, R. K.; Phillips, N. R.; Planz, J. V.; Sedlazeck, F. J.; Zascavage, R. R.
10.1101/2021.07.01.450747 — genetics — Posted on 2021-07-02
3809 Evidence that nuclear receptors evolved from terpene synthases
Houston, D. R.; Hanna, J. G.; Lathe, J. C.; Hillier, S. G.; Lathe, R.
10.1101/2021.06.29.450438 — evolutionary biology — Posted on 2021-07-02
3810 Optimized nickase- and nuclease-based prime editing in human and mouse cells
Adikusuma, F.; Lushington, C.; Arudkumar, J.; Godahewa, G. I.; Chey, Y. C. J.; Gierus, L.; Piltz, S.; Reti, D.; Wilson, L.; Bauer, D.; Thomas, P.
10.1101/2021.07.01.450810 — molecular biology — Posted on 2021-07-02
3812 Diversity and distribution of sulfur metabolism in the human gut microbiome and its association with colorectal cancer
Wolf, P. G.; Cowley, E. S.; Breister, A.; Matatov, S.; Lucio, L.; Polak, P.; Ridlon, J. M.; Gaskins, H. R.; Anantharaman, K.
10.1101/2021.07.01.450790 — microbiology — Posted on 2021-07-02
3813 Evolution of the quorum sensing regulon in cooperating populations of Pseudomonas aeruginosa
Smalley, N. E.; Schaefer, A. L.; Asfahl, K. L.; Perez, C.; Greenberg, E. P.; Dandekar, A. A.
10.1101/2021.07.01.450773 — microbiology — Posted on 2021-07-02
3815 Phenogenomic characterization of a newly domesticated and novel species from the genus Verrucosispora
Kennedy, S.; Atkinson, C.; Tomlinson, B.; Hammond, L.; Eswara, P. J.; Baker, B. J.; Shaw, L. N.
10.1101/2021.07.01.450820 — microbiology — Posted on 2021-07-02
3818 Gaussian accelerated molecular dynamics reveals that a proline-rich signaling peptide frequently samples cis conformations when unbound
Alcantara, J.; Stix, R.; Huang, K.; Connor, A.; East, R.; Jaramillo-Martinez, V.; Stollar, E. J.; Ball, K. A.
10.1101/2021.07.01.450746 — biophysics — Posted on 2021-07-02
3820 Suppression of sost/sclerostin and dikkopf-1 promote intervertebral disc structure in mice
Kroon, T. M.; Niziolek, P.; Edwards, D.; Clinkenbeard, E. L.; Robling, A. G.; Holguin, N.
10.1101/2021.07.01.449486 — bioengineering — Posted on 2021-07-02
3822 Fungal community composition along a gradient of permafrost thaw
Kluge, M.; Wurzbacher, C.; Wauthy, M.; Engelbrecht Clemmensen, K.; Hawkes, J.; Einarsdottir, K.; Stenlid, J.; Peura, S.
10.1101/2021.07.01.450738 — ecology — Posted on 2021-07-02
3823 Natural infection of SARS-CoV-2 delta variant in Asiatic lions (Panthera leo persica) in India
Mishra, A.; Kumar, N.; Bhatia, S.; Aasdev, A.; Kanniappan, S.; Thayasekhar, A.; Gopinadhan, A.; Silambarasan, R.; Sreekumar, C.; Dubey, C. K.; Tripathi, M.; Raut, A. A.; Singh, V. P.
10.1101/2021.07.02.450663 — microbiology — Posted on 2021-07-02
3824 Neutralization of Delta variant with sera of Covishield vaccinees and COVID-19 recovered vaccinated individuals
Sapkal, G.; Yadav, P. D.; Sahay, R. R.; Deshpande, G.; Gupta, N.; Nyayanit, D. A.; Patil, D. Y.; Kumar, S.; Abraham, P.; Panda, S.; Bhargava, B.
10.1101/2021.07.01.450676 — microbiology — Posted on 2021-07-02
3825 Idiopathic chronic diarrhea in rhesus macaques is not associated with enteric viral infections
Delwart, E.; Tisza, M. J.; Altan, E.; Li, Y.; Deng, X.; Hartigan-O'Connor, J. D.; Ardeshir, A.
10.1101/2021.07.01.450785 — microbiology — Posted on 2021-07-02
3827 Loss of GdpP function in Staphylococcus aureus leads to β-lactam tolerance and enhanced evolution of β-lactam resistance
Poon, R.; Basuino, L.; Satishkumar, N.; Chatterjee, A.; Mukkayyan, N.; Buggeln, E.; Huang, L.; Nair, V.; Argudin, M. A.; Datta, S. K.; Chambers, H. F.; Chatterjee, S. S.
10.1101/2021.07.02.449101 — microbiology — Posted on 2021-07-02
3829 Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint
Masle-Farquhar, E.; Peters, T. J.; Miosge, L. A.; Parish, I. A.; Weigel, C.; Oakes, C. C.; Reed, J. H.; Goodnow, C.
10.1101/2021.07.01.450650 — immunology — Posted on 2021-07-02
3830 Qualification of ELISA and neutralization methodologies to measure SARS-CoV-2 humoral immunity using human clinical samples
Larsen, S. E.; Berube, B. J.; Pecor, T.; Cross, E.; Brown, B. P.; Williams, B.; Johnson, E.; Qu, P.; Carter, L.; Wren, S.; Kepl, E.; Sydeman, C.; King, N. P.; Baldwin, S. L.; Coler, R. N.
10.1101/2021.07.02.450915 — immunology — Posted on 2021-07-02
3832 Implications of Spike-glycoprotein processing at S1/S2 by Furin, at S2' by Furin and/or TMPRSS2 and shedding of ACE2: cell-to-cell fusion, cell entry and infectivity of SARS-CoV-2
Essalmani, R.; Jain, J.; Susan-Resiga, D.; Andreo, U.; Evagelidis, A.; Derbali, M.; Huynh, D.; Dallaire, F.; Laporte, M.; Delpal, A.; Sutto-Ortiz, P.; Coutard, B.; Mapa, C.; Wilcoxen, K.; Decroly, E.; Pham, T. N.; Cohen, E. A.; Seidah, N. G.
10.1101/2021.07.02.450896 — biochemistry — Posted on 2021-07-02
3833 Chasing perfection: validation and polishing strategies for telomere-to-telomere genome assemblies
Mc Cartney, A. M.; Shafin, K.; Alonge, M.; Bzikadze, A. V.; Formenti, G.; Fungtammasan, A.; Howe, K.; Jain, C.; Koren, S.; Logsdon, G. A.; Miga, K. H.; Mikheenko, A.; Paten, B.; Shumate, A.; Soto, D. C.; Sovic, I.; Wood, J. M.; Zook, J. M.; Phillippy, A. M.; Rhie, A.
10.1101/2021.07.02.450803 — genomics — Posted on 2021-07-02
3834 Betacoronavirus-specific alternate splicing
Karlebach, G.; Aronow, B. J.; Baylin, S. J.; Butler, D.; Foox, J.; Levy, S.; Meydan, C.; Mozsary, C.; Saravia-Butler, A. M.; Taylor, D. M.; Wurtele, E.; Mason, C.; Beheshti, A.; Robinson, P. N.
10.1101/2021.07.02.450920 — genomics — Posted on 2021-07-02
3835 DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression
Kong, T.; Laranjeira, A. B. A.; Yang, K.; Fisher, D.; Yu, L.; Wang, A. Z.; Ruzinova, M.; Fowles, J.; Allen, M.; Celik, H.; Challen, G.; Huang, S.; Oh, S.
10.1101/2021.06.27.449656 — cancer biology — Posted on 2021-07-02
3838 Acquisition of cancer stem cell properties during EMT requires cell division
den Hollander, P.; Vasaikar, S. V.; Castaneda, M.; Joseph, R.; Deshmukh, A. P.; Zhao, T.; Pietila, M.; Fu, C.; Symmans, W. F.; Soundararajan, R.; Mani, S. A.
10.1101/2021.07.01.449976 — cell biology — Posted on 2021-07-02
3839 Immune complex solubility and size govern Fc-gamma receptor responses: A scalable cell-based reporter system
Chen, H.; Maul-Pavicic, A.; Holzer, M.; Salzer, U.; Chevalier, N.; Voll, R. E.; Hengel, H.; Kolb, P.
10.1101/2020.11.11.378232 — immunology — Posted on 2021-07-02
3841 Distinct roles of nonmuscle myosin II isoforms for establishing tension and elasticity during cell morphogenesis
Weissenbruch, K.; Grewe, J.; Hippler, M.; Fladung, M.; Tremmel, M.; Stricker, K.; Schwarz, U. S.; Bastmeyer, M.
10.1101/2020.10.09.333203 — biophysics — Posted on 2021-07-02
3842 Assembled Cell-Decorated Collagen (AC-DC) bioprinted implants mimic musculoskeletal tissue properties and promote functional recovery
Christensen, K. W.; Turner, J.; Coughenour, K.; Maghdouri-White, Y.; Bulysheva, A. A.; Sergeant, O.; Rariden, M.; Randazzo, A.; Sheean, A. J.; Christ, G. J.; Francis, M. P.
10.1101/2021.06.22.449431 — bioengineering — Posted on 2021-07-02
3844 Development of epigenetic clocks for New Zealand livestock
Caulton, A.; Dodds, K. G.; McRae, K. M.; Couldrey, C.; Horvath, S.; Clarke, S. M.
10.1101/2021.06.30.450497 — genomics — Posted on 2021-07-02
3849 Extent, impact, and mitigation of batch effects in tumor biomarker studies using tissue microarrays
Stopsack, K. H.; Tyekucheva, S.; Wang, M.; Gerke, T. A.; Vaselkiv, J. B.; Penney, K. L.; Kantoff, P. W.; Finn, S. P.; Fiorentino, M.; Loda, M.; Lotan, T. L.; Parmigiani, G.; Mucci, L. A.
10.1101/2021.06.29.450369 — pathology — Posted on 2021-07-02
3850 The Myogenesis Program Drives Clonal Selection and Drug Resistance in Rhabdomyosarcoma
Patel, A. G.; Chen, X.; Huang, X.; Clay, M. R.; Komarova, N.; Krasin, M. J.; Pappo, A.; Tillman, H.; Orr, B. A.; McEvoy, J.; Gordon, B.; Blankenship, K.; Reilly, C.; Zhou, X.; Norrie, J. L.; Karlstrom, A.; Yu, J.; Wodarz, D.; Stewart, E.; Dyer, M. A.
10.1101/2021.06.16.448386 — cancer biology — Posted on 2021-07-02
3852 Aerobiology in High Latitudes: Evidence of Bacteria Acting as Tracer of Warm Air Mass Advection reaching Northern Antarctic Peninsula
Cataldo, M.; Evangelista, H.; Pereira, J. A. A.; Bertho, A. L.; Pellizari, V.; Kuhn, E.; Sampaio, M.; da Cunha, K. D.; Alencar, A.; Amaral, C.
10.1101/2021.06.27.450079 — biophysics — Posted on 2021-07-02
3854 Unsupervised Spatial Embedded Deep Representation of Spatial Transcriptomics
Fu, H.; Xu, H.; Chong, K.; Li, M.; Ang, K. S.; Lee, H. K.; Lin, J.; Chen, A.; Shao, L.; Liu, L.; Chen, J.
10.1101/2021.06.15.448542 — bioinformatics — Posted on 2021-07-02
3858 Evolution of a minimal cell
Moger-Reischer, R. Z.; Glass, J. I.; Wise, K.; Bittencourt, D.; Sun, L.; Lynch, M.; Lennon, J. T.
10.1101/2021.06.30.450565 — evolutionary biology — Posted on 2021-07-02
3859 Reproductive biology of wild and domesticated Ensete ventricosum: Further evidence for maintenance of sexual reproductive capacity in a vegetatively propagated perennial crop
Tamrat, S.; Borrell, J. S.; Shiferaw, E.; Wondimu, T.; Kallow, S. S.; Davies, R. M.; Dickie, J. B.; Nuraga, G. W.; White, O.; Woldeyes, F.; Demissew, S.; Wilkin, P.
10.1101/2020.04.30.055582 — ecology — Posted on 2021-07-02
3861 The nematode worm C. elegans chooses between bacterial foods exactly as if maximizing economic utility
Katzen, A.; Chung, H.-K.; Harbaugh, W.; Iacono, C. D.; Jackson, N.; Yu, S.; Flavell, S. W.; Glimcher, P.; Lockery, S.
10.1101/2021.04.25.441352 — neuroscience — Posted on 2021-07-02
3862 On the topochronic map of the human brain dynamics
Sorrentino, P.; Petkoski, S.; Sparaco, M.; Troisi Lopez, E.; Rucco, R.; Signoriello, E.; Baselice, F.; Bonavita, S.; Pirozzi, M. A.; Quarantelli, M.; Sorrentino, G.; Jirsa, V.
10.1101/2021.07.01.447872 — neuroscience — Posted on 2021-07-02
3863 Hematopoietic differentiation is characterized by a transient peak of entropy at a single cell level.
Dussiau, C.; Boussaroque, A.; Gaillard, M.; Bravetti, C.; Zaroili, L.; Knosp, C.; Friedrich, C.; Asquier, P.; Willems, L.; Quint, L.; Bouscary, D.; Fontenay, M.; Espinasse, T.; Plesa, A.; Sujobert, P.; Gandrillon, O.; Kosmider, O.
10.1101/2021.04.30.442092 — systems biology — Posted on 2021-07-02
3865 Natural selection promotes the evolution of recombination 2: during the selective process
Gerrish, P. J.; Cordero, F.; Galeota-Sprung, B.; Colato, A.; Vejalla, V.; Sniegowski, P. D.; Hengartner, N. W.
10.1101/2021.06.07.447324 — evolutionary biology — Posted on 2021-07-02
3867 Cerebrospinal fluids from healthy pregnant women does not harbor a detectable microbial community
Kang, Y.; Ji, X.; Guo, L.; Xia, H.; Yang, X.; Xie, Z.; Shi, X.; Wu, R.; Feng, D.; Wang, C.; Chen, M.; Zhang, W.; Wei, H.; Guan, Y.; Ye, K.; Zhao, G.
10.1101/2020.09.16.299065 — microbiology — Posted on 2021-07-02
3869 On the topochronic map of the human brain dynamics
Sorrentino, P.; Petkoski, S.; Sparaco, M.; Troisi Lopez, E.; Rucco, R.; Signoriello, E.; Baselice, F.; Bonavita, S.; Pirozzi, M. A.; Quarantelli, M.; Sorrentino, G.; Jirsa, V.
10.1101/2021.07.01.447872 — neuroscience — Posted on 2021-07-02
3870 Oligodendrocytes depend on MCL-1 to prevent spontaneous apoptosis and white matter degeneration
Cleveland, A. H.; Romero-Morales, A.; Alfonso Azcona, L.; Herrero, M.; Nikolova, V. D.; Moy, S.; Elroy-Stein, O.; Gama, V.; Gershon, T. R.
10.1101/2020.12.02.408138 — neuroscience — Posted on 2021-07-02
3875 Improved correspondence of fMRI visual field localizer data after macroanatomical alignment
Qubad, M.; Barnes-Scheufler, C. V.; Schaum, M.; Raspor, E.; Roesler, L.; Peters, B.; Goebel, R.; Reif, A.; Bittner, R. A.
10.1101/2021.02.26.433066 — neuroscience — Posted on 2021-07-02
3878 GranatumX: A community engaging, modularized and flexible webtool for single-cell analysis
Zhu, X.; Yunits, B.; Wolfgruber, T.; Liu, Y.; Huang, Q.; Poirion, O.; Arisdakessian, C.; Zhao, T.; Garmire, D.; Garmire, L.; Stanojevic, S.
10.1101/385591 — bioinformatics — Posted on 2021-07-01
3880 Natural selection promotes the evolution of recombination 1: among selected genotypes
Gerrish, P. J.; Galeota-Sprung, B. J.; Sniegowski, P. D.; Chevallier, J.; Ycart, B.
10.1101/2021.06.07.447320 — evolutionary biology — Posted on 2021-07-02
3881 Natural selection and the advantage of recombination
Gerrish, P. J.; Galeota-Sprung, B.; Cordero, F.; Sniegowski, P. D.; Colato, A.; Hengartner, N. W.; Vejalla, V.; Chevalier, J.; Ycart, B.
10.1101/2020.08.28.271486 — evolutionary biology — Posted on 2021-07-02
3882 A Guide to Pre-Processing High-Throughput Animal Tracking Data
Gupte, P. R.; Beardsworth, C. E.; Spiegel, O.; Lourie, E.; Toledo, S.; Nathan, R.; Bijleveld, A. I.
10.1101/2020.12.15.422876 — ecology — Posted on 2021-07-02
3883 Impacts of an urban sanitation intervention on fecal indicators and the prevalence of human fecal contamination in Mozambique
Holcomb, D. A.; Knee, J.; Capone, D.; Sumner, T.; Adriano, Z.; Nala, R.; Cumming, O.; Brown, J.; Stewart, J. R.
10.1101/2021.02.19.432000 — microbiology — Posted on 2021-07-02
3886 Single-cell anatomical analysis of human hippocampus and entorhinal cortex uncovers early-stage molecular pathology in Alzheimer's disease
Davila-Velderrain, J.; Mathys, H.; Mohammadi, S.; Ruzicka, W. B.; Jiang, X.; Ng, A.; Bennett, D. A.; Tsai, L.-H.; Kellis, M.
10.1101/2021.07.01.450715 — neuroscience — Posted on 2021-07-01
3887 Spectro-temporal neural dynamics during sentence completion
Coolen, T.; Dumitrescu, A. M.; Wens, V.; Bourguignon, M.; Gomez, G. L.; Rovai, A.; Sadeghi, N.; Urbain, C.; Goldman, S.; De Tiege, X.
10.1101/2021.07.01.450734 — neuroscience — Posted on 2021-07-01
3889 Hierarchical modelling of functional brain networks in population and individuals from big fMRI data
Farahibozorg, S.-R.; Bijsterbosch, J. D.; Gong, W.; Jbabdi, S.; Smith, S. M.; Harrison, S. J.; Woolrich, M. W.
10.1101/2021.02.01.428496 — neuroscience — Posted on 2021-07-02
3891 CHROMOMETHYLTRANSFERASE3/KRYPTONITE maintain the sulfurea paramutation in Solanum lycopersicum
Martinho, C.; Wang, Z.; Ghigi, A.; Buddle, S.; Barbour, F.; Yarur, A.; Gouil, Q.; Muller, S.; Stam, M.; Liu, C.; Baulcombe, D. C.
10.1101/2021.07.01.450764 — plant biology — Posted on 2021-07-01
3892 Strategies for the site-specific decoration of DNA origami nanostructures with functionally intact proteins
Hellmeier, J.; Platzer, R.; Muehlgrabner, V.; Schneider, M. C.; Kurz, E.; Schuetz, G. J.; Huppa, J. B.; Sevcsik, E.
10.1101/2021.07.01.450695 — biophysics — Posted on 2021-07-01
3893 Biosynthetic Glycan Labeling
Marando, V. M.; Kim, D. E.; Calabretta, P. J.; Kraft, M. B.; Bryson, B. D.; Kiessling, L. L.
10.1101/2021.07.01.450741 — biochemistry — Posted on 2021-07-01
3896 Improved Metabolite Prediction Using Microbiome Data-Based Elastic Net Models
Xie, J.; Cho, H.; Lin, B. M.; Pillai, M.; Heimisdottir, L.; Bandyopadhyay, D.; Zou, F.; Roach, J.; Divaris, K.; Wu, D.
10.1101/2021.07.01.450697 — microbiology — Posted on 2021-07-01
3898 Hypervariable-Locus Melting Typing (HLMT): a novel, fast and inexpensive sequencing-free approach to pathogen typing based on High Resolution Melting (HRM) analysis
Perini, M.; Piazza, A.; Panelli, S.; Papaleo, S.; Alvaro, A.; Vailati, F.; Corbella, M.; Saluzzo, F.; Gona, F.; Castelli, D.; Farina, C.; Marone, P.; Cirillo, D. M.; Cavallero, A.; Zuccotti, G. V.; Comandatore, F.
10.1101/2021.07.01.450706 — microbiology — Posted on 2021-07-01
3899 A novel α/β T-cell subpopulation defined by recognition of EPCR
Arrondo, E. E.; Moran-Garrido, M.; Saiz, J.; Barbas, C.; Dichiara Rodriguez, M. G.; Ramirez, N.; Lopez-Sagaseta, J.
10.1101/2021.07.01.450412 — immunology — Posted on 2021-07-01
3901 Activation of Adipocyte mTORC1 Increases Milk Lipids in a Mouse Model of Lactation
El-Habbal, N.; Meyer, A. C.; Hafner, H.; Redd, J. R.; Carlson, Z.; Mulcahy, M. C.; Gregg, B.; Bridges, D.
10.1101/2021.07.01.450596 — physiology — Posted on 2021-07-01
3902 Effects of High-Volume versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations
Vann, C.; Sexton, C.; Osburn, S.; Smith, M.; Haun, C.; Rumbley, M.; Mumford, P.; Ferguson, B.; Montgomery, N.; Fox, C.; Ruple, B.; McKendry, J.; McLeod, J.; Bashir, A.; Beyers, R.; Brook, M.; Smith, K.; Atherton, P.; Beck, D.; McDonald, J.; Young, K.; Phillips, S.; Roberts, M.
10.1101/2021.07.01.450728 — physiology — Posted on 2021-07-01
3904 Gasdermin B over-expression arbitrates HER2-targeted therapy resistance by inducing protective autophagy
Gamez-Chiachio, M.; Molina-Crespo, A.; Martinez-Val, J.; Martinez, L.; Gassner, K.; Llobet, F. J.; Gonzalo-Consuegra, C.; Cordani, M.; Bernado-Morales, C.; Diaz, E.; Rojo-Sebastian, A.; Trivino, J. C.; Sanchez, L.; Rodriguez-Barrueco, R.; Arribas, J.; Llobet-Navas, D.; Sarrio, D.; Moreno-Bueno, G.
10.1101/2021.07.01.450506 — cancer biology — Posted on 2021-07-01
3906 Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a
Burbidge, O.; Pastok, M. W.; Hodder, S. L.; Zenkeviciute, G.; Noble, M. E.; Endicott, J. A.; Itzhaki, L.
10.1101/2021.07.01.450670 — biochemistry — Posted on 2021-07-01
3907 RNA and the Goldilocks Zone: Where Mg2+ concentration is just right
Guth-Metzler, R.; Mohamed, A. M.; Cowan, E. T.; Frenkel-Pinter, M.; Wartell, R.; Glass, J. B.; Williams, L. D.
10.1101/2021.07.01.450745 — biochemistry — Posted on 2021-07-01
3908 Size Matters: A Mechanistic Model of Nanoparticle Curvature Effects on Amyloid Fibril Formation
John, T.; Adler, J.; Elsner, C.; Petzold, J.; Krueger, M.; Martin, L. L.; Huster, D.; Risselada, H. J.; Abel, B.
10.1101/2021.07.01.450782 — biochemistry — Posted on 2021-07-01
3909 CRISPRa screening with real world evidence identifies potassium channels as neuronal entry factors and druggable targets for SARS-CoV-2
Wang, C.; Dinesh, R.; Qu, Y.; Rustagi, A.; Cousins, H.; Zengel, J.; Guo, Y.; Hall, T.; Beck, A.; Tso, L.; Erdemic, E.; Tanudtanud, K.; Ren, S.; Tzeng, K. T.-H.; Wilk, A.; Wang, M.; Carette, J.; Altman, R.; Blish, C.; Cong, L.
10.1101/2021.07.01.450475 — genomics — Posted on 2021-07-01
3914 CRISPR/Cas9 deletions induce adverse on-target genomic effects leading to functional DNA in human cells
Geng, K.; Merino, L. G.; Wedemann, L.; Martens, A.; Sobota, M.; Sondergaard, J. N.; White, R. J.; Kutter, C.
10.1101/2021.07.01.450727 — molecular biology — Posted on 2021-07-01
3915 Thiol-based mucolytics exhibit antiviral activity against SARS-CoV-2 through allosteric disulfide disruption in the spike glycoprotein
Shi, Y.; Zeida, A.; Edwards, C. E.; Mallory, M. L.; Sastre, S.; Machado, M. R.; Pickles, R. J.; Fu, L.; Liu, K.; Yang, J.; Baric, R. S.; Boucher, R. C.; Radi, R.; Carroll, K. S.
10.1101/2021.07.01.450701 — microbiology — Posted on 2021-07-01
3917 Lager yeast design through meiotic segregation of a fertile Saccharomyces cerevisiae x Saccharomyces eubayanus hybrid
Krogerus, K.; Magalhaes, F.; Castillo, S.; Peddinti, G.; Vidgren, V.; De Chiara, M.; Yue, J.-X.; Liti, G.; Gibson, B.
10.1101/2021.07.01.450509 — microbiology — Posted on 2021-07-01
3920 Structural basis of membrane recognition of Toxoplasma gondii vacuole by Irgb6
Hamano, Y. S.; Sherif, A. A.; Pradipta, A.; Sasai, M.; Sakai, N.; Sakihama, Y.; Yamamoto, M.; Standley, D. M.; Nitta, R.
10.1101/2021.07.01.450801 — microbiology — Posted on 2021-07-01
3921 Ad26.COV2.S elicited neutralizing activity against Delta and other SARS-CoV-2 variants of concern
Jongeneelen, M.; Kaszas, K.; Veldman, D.; Huizingh, J.; van der Vlugt, R.; Schouten, T.; Zuijdgeest, D.; Uil, T.; van Roey, G.; Guimera, N.; Navis, M.; Bos, R.; Le Gars, M.; Sadoff, J.; Muchene, L.; Juraszek, J.; Langedijk, J. P.; Vogels, R.; Custers, J.; Schuitemaker, H.; Brandenburg, B.
10.1101/2021.07.01.450707 — immunology — Posted on 2021-07-01
3922 Macrophage Circadian Rhythms are Differentially Affected Based on Stimuli
Don, S. S. L.; Mas-Rosario, J. A.; Lin, H.-H.; Nguyen, M.; Taylor, S. R.; Farkas, M. E.
10.1101/2021.07.01.450771 — immunology — Posted on 2021-07-01
3923 Dendro-somatic synaptic inputs to ganglion cells violate receptive field and connectivity rules in the mammalian retina
Sedlacek, M.; Grimes, W.; Musgrove, M.; Nath, A.; Tian, H.; Hoon, M.; Rieke, F.; Singer, J. H.; Diamond, J. S.
10.1101/2021.07.01.450751 — neuroscience — Posted on 2021-07-01
3927 Deciphering the tumor-specific immunopeptidome in vivo with genetically engineered mouse models
Jaeger, A. M.; Stopfer, L. E.; Sanders, E.; Sandel, D.; Freed-Pastor, W.; Rideout, W.; Naranjo, S.; Fessenden, T.; Winter, P. S.; Kohn, R.; Schenkel, J.; Shanahan, S.-L.; Shalek, A. K.; Spranger, S.; White, F.; Jacks, T.
10.1101/2021.06.30.450516 — cancer biology — Posted on 2021-07-01
3932 Fungal effector SIB1 of Colletotrichum orbiculare has unique structural features and can suppress plant immunity in Nicotiana benthamiana
Zhang, R.; Isozumi, N.; Mori, M.; Okuta, R.; Singkaravanit-Ogawa, S.; Imamura, T.; Gan, P.; Shirasu, K.; Ohki, S.; Takano, Y.
10.1101/2021.07.01.450775 — microbiology — Posted on 2021-07-01
3935 Genome-wide association study and functional validation implicates JADE1 in tauopathy
Farrell, K.; Kim, S.; Han, N.; Iida, M. A.; Gonzalez, E.; Otero-Garcia, M.; Walker, J.; Richardson, T.; Renton, A. E.; Andrews, S. J.; Fulton-Howard, B.; Humphrey, J.; Vialle, R. A.; Bowles, K. R.; Whitney, K.; Dangoor, D. K.; Marcora, E.; Hefti, M. M.; Casella, A.; Bhangale, T.; Hunkapiller, J.; Ayalon, G.; Graham, R.; Cherry, J. D.; Cortes, E.; Borukov, V.; McKee, A. C.; Stein, T. D.; Vonsattel, J. P.; Teich, A. F.; Gearing, M.; Glass, J.; Troncoso, J. C.; Frosch, M. P.; Hyman, B. T.; Dickson, D. W.; Murray, M. E.; Attems, J.; Flanagan, M. E.; Mao, Q.; Mesulam, M. M.; Weintraub, S.; Woltjer,
10.1101/2021.06.30.450599 — neuroscience — Posted on 2021-07-01
3936 Intrinsic Network Activity Reflects the Ongoing Experience of Chronic Pain
Jahn, P.; Deak, B.; Mayr, A.; Stankewitz, A.; Keeser, D.; Griffanti, L.; Witkovsky, V.; Irving, S.; Schulz, E.
10.1101/2021.06.30.450604 — neuroscience — Posted on 2021-07-01
3937 GABAA α Subunit Control of Hyperactive Behavior in Developing Zebrafish
Barnaby, W. W.; Dorman, H. E.; Nagarkar, A.; Perkins, M.; Teicher, G.; Trapani, J. G.; Downes, G. B.
10.1101/2021.07.01.450600 — neuroscience — Posted on 2021-07-01
3939 Organization of the catecholaminergic system in the short-lived fish Nothobranchius furzeri
Borgonovo, J.; Ahumada-Galleguillos, P.; Onate-Ponce, A.; Allende-Castro, C.; Henny, P.; Concha, M. L.
10.1101/2021.06.30.450602 — neuroscience — Posted on 2021-07-01
3940 Two faces of perceptual awareness during the attentional blink: Gradual and discrete
Karabay, A.; Wilhelm, S. A.; de Jong, J.; Wang, J.; Martens, S.; Akyurek, E. G.
10.1101/769083 — neuroscience — Posted on 2021-07-01
3944 High throughput measurement of Arabidopsis thaliana fitness traits using transfer learning
Wang, P.; Meng, F.; Donaldson, P.; Horan, S.; Panchy, N. L.; Vischulis, E.; Winship, E.; Conner, J. K.; Lehti-Shiu, M. D.; Shiu, S.-H.
10.1101/2021.07.01.450758 — bioinformatics — Posted on 2021-07-01
3946 Prolonging coagulant activity of factor Xa under hemophilic conditions by site-specific N-glycosylation of the surface-exposed autolysis loop
Bonde, A. C.; Lund, J.; Hansen, J. J.; Winther, J. R.; Zahn, S.; Tiainen, P.; Olsen, O. H.; Petersen, H. H.; Bjelke, J. R.
10.1101/2021.07.01.450767 — biochemistry — Posted on 2021-07-01
3947 Functional profiling of long intergenic non-coding RNAs in fission yeast
Rodriguez-Lopez, M.; Anver, S.; Cotobal, C.; Kamrad, S.; Malecki, M.; Correia-Melo, C.; Hoti, M.; Townsend, S.; Marguerat, S. B.; Pong, S.; Wu, M.; Montemayor, L.; Howell, M.; Ralser, M.; Bahler, J.
10.1101/2021.06.30.450572 — genetics — Posted on 2021-07-01
3952 The method of choice to knock-in large inserts via CRISPR
Marks, D.; Bachmann, L.; Gallego Villarejo, L.; Geidies, A.; Heinen, N.; Anstatt, J.; Mueller, T.
10.1101/2021.07.01.450700 — molecular biology — Posted on 2021-07-01
3962 Comprehensive transcriptomic analysis shows disturbed calcium homeostasis and deregulation of T lymphocyte apoptosis in inclusion body myositis
Johari, M.; Vihola, A.; Palmio, J.; Jokela, M.; Jonson, P. H.; Sarparanta, J.; Huovinen, S.; Savarese, M.; Hackman, P.; Udd, B.
10.1101/2021.06.30.450477 — neuroscience — Posted on 2021-07-01
3965 Mechanistic model-driven exometabolomic characterisation of human dopaminergic neuronal metabolism
Preciat, G.; Moreno, E. L.; Wegrzyn, A.; Willacey, C. C. W.; Modamio, J.; Monteiro, F. L.; El Assal, D.; Schurink, A.; Oliveira, M. A. P.; Zhang, Z.; Cousins, B.; Zach, S.; Vempala, S.; Hengerer, B.; Harms, A.; Schwamborn, J. C.; Thiele, I.; Hankemeier, T.; Fleming, R. M.
10.1101/2021.06.30.450562 — systems biology — Posted on 2021-07-01
3967 Small Vessel Diseases: 3D Characteristics of the Vasculature and White Matter
Saito, R.; Tainaka, K.; Nozaki, H.; Uemura, M.; Toyoshima, Y.; Suzuki, M.; Tanaka, M.; Hasegawa, A.; Abe, T.; Sato, A.; Hashidate, H.; Igarashi, S.; Koike, R.; Ueda, A.; Ueda, M.; Ando, Y.; Akazawa, K.; ONODERA, O.; Kakita, A.
10.1101/2021.06.30.450101 — pathology — Posted on 2021-07-01
3968 Proximity-dependent biotinylation to elucidate the interactome of TNK2 non-receptor tyrosine kinase
Tahir, R.; Madugundu, A. K.; Udainiya, S.; Cutler, J. A.; Renuse, S.; Wang, L.; Pearson, N. A.; Mitchell, C.; Mahajan, N.; Pandey, A.; Wu, X.
10.1101/2021.06.30.450607 — cancer biology — Posted on 2021-07-01
3971 Optimal balancing of clinical factors in large scale clinical RNA-Seq studies
CHIANG, A. W. T.; Gazestani, V. H.; Altieri, M. G.; Courchesne, E.; Lewis, N. E.
10.1101/2021.06.30.450639 — bioinformatics — Posted on 2021-07-01
3975 Network-Based Discovery of Opioid Use Vulnerability in Rats Using the Bayesian Stochastic Block Model
Allen, C.; Kuhn, B. N.; Cannella, N.; Crow, A. D.; Roberts, A. T.; Lunerti, V.; Ubaldi, M.; Hardiman, G.; Solberg Woods, L. C.; Ciccocioppo, R.; Kalivas, P. W.; Chung, D.
10.1101/2021.06.30.450568 — animal behavior and cognition — Posted on 2021-07-01
3978 Genome of the parasitoid wasp Dinocampus coccinellae reveals extensive duplications, accelerated evolution, and independent origins of thelytokous parthenogeny and solitary behavior
Sethuraman, A.; Tovar, A.; Grenier, C.; Welch, W.; Arce, C.; Dettmers, R.; Skaggs, T.; Rothenberg, A.; Saisho, R.; Summerhays, B.; Cartmill, R.; Vasquez, Y.; Vansant, H.; Obrycki, J. J.
10.1101/2021.06.30.450623 — genomics — Posted on 2021-07-01
3979 Probing molecular specificity with deep sequencing and biophysically interpretable machine learning
Rube, H. T.; Rastogi, C.; Feng, S.; Kribelbauer, J. F.; Li, A.; Becerra, B.; Melo, L. A. N.; Do, B. V.; Li, X.; Adam, H. H.; Shah, N. H.; Mann, R. S.; Bussemaker, H. J.
10.1101/2021.06.30.450414 — genomics — Posted on 2021-07-01
3984 The histone chaperone FACT facilitates heterochromatin spreading through regulation of histone turnover and H3K9 methylation states
Murawska, M.; Greenstein, R. A.; Schauer, T.; Olsen, K. C. F.; Ng, H.; Ladurner, A. G.; Al-Sady, B.; Braun, S.
10.1101/2021.06.30.450523 — genetics — Posted on 2021-07-01
3985 daf-16/FOXO blocks adult cell fate in Caenorhabditis elegans dauer larvae via lin-41/TRIM71
Wirick, M. J.; Cale, A. R.; Smith, I. T.; Alessi, A. F.; Starostik, M. R.; Cuko, L.; Lalk, K.; Schmidt, M. N.; Olson, B. S.; Salomon, P. M.; Santos, A.; Schmitter-Sanchez, A.; Galagali, H.; Ranke, K. J.; Wolbert, P. A.; Knoblock, M. L.; Kim, J. K.; Karp, X.
10.1101/2021.06.30.450637 — genetics — Posted on 2021-07-01
3987 A supergene in seaweed flies modulates male traits and female perception
Enge, S.; Merot, C.; Mozuraitis, R.; Apsegaite, V.; Bernatchez, L.; Martens, G. A.; Radziute, S.; Pavia, H.; Berdan, E. L.
10.1101/2021.06.30.450538 — evolutionary biology — Posted on 2021-07-01
3992 Life history mediates the trade-offs among different components of demographic resilience
Capdevila, P.; Stott, I.; Cant, J.; Beger, M.; Rowlands, G.; Grace, M.; Salguero-Gomez, R.
10.1101/2021.06.30.450480 — ecology — Posted on 2021-07-01
3994 A transferable IncC-IncX3 hybrid plasmid co-carrying blaNDM-4, tet(X4), and tmexCD3-toprJ3 confers resistance to carbapenem and tigecycline
Hirabayashi, A.; Dao, T. D.; Takemura, T.; Hasebe, F.; Trang, L. T.; Thanh, N. H.; Tran, H. H.; Shibayama, K.; Kasuga, I.; Suzuki, M.
10.1101/2021.06.30.450641 — microbiology — Posted on 2021-07-01
3996 ICER controls HIV-1 infection and replication in elite controllers
Luo, Z.; Li, M.; Li, T.; Lv, Z.; Ye, Z.; Cisneros, W. J.; Zhang, J.; Yuan, L.; Hultquist, J. F.; Migueles, S.; Zhu, J.; Jiang, W.
10.1101/2021.06.30.450567 — immunology — Posted on 2021-07-01
3998 Early neuroadaptations to an obesogenic diet identify the schizophrenia-related ErbB4 receptor in obesity-induced hippocampal abnormalities
Vega-Torres, J. D.; Ontiveros-Angel, P.; Terrones, E.; Stuffle, E. C.; Solak, S.; Tyner, E.; Oropeza, M.; Dela Pena, I.; Obenaus, A.; Ford, B. D.; Figueroa, J. D.
10.1101/2021.06.30.450398 — neuroscience — Posted on 2021-07-01
3999 Genomic Modules and Intramodular Network Convergency of Susceptibility and Resilience in Multimodeled Stress in Male Mice
Marrocco, J.; Caradonna, S. G.; Zhang, T.-Y.; O'Toole, N.; Shen, M.-J.; Khalil, H.; Einhorn, N.; Wen, X.; Parent, C.; Lee, F. S.; Akil, H.; McEwen, B.; Meaney, M. J.
10.1101/2021.06.30.450390 — neuroscience — Posted on 2021-07-01
4000 Deficiency of the ywhaz gene, involved in neurodevelopmental disorders, alters brain activity and behaviour in zebrafish
Anton-Galindo, E.; Dalla Vecchia, E.; Orlandi, J. G.; Castro, G.; Gualda, E.; Loza-Alvarez, P.; Aguado, F.; Norton, W. H.; Cormand, B.; Fernandez-Castillo, N.
10.1101/2021.06.30.450513 — neuroscience — Posted on 2021-07-01
4001 Individually Unique Dynamics of Cortical Connectivity Reflect the Ongoing Intensity of Chronic Pain
Mayr, A.; Jahn, P.; Deak, B.; Stankewitz, A.; Devulapally, V.; Witkovsky, V.; Dietrich, O.; Schulz, E.
10.1101/2021.06.30.450553 — neuroscience — Posted on 2021-07-01
4004 Intrinsic Network Activity Reflects the Fluctuating Experience of Tonic Pain
Deak, B.; Eggert, T.; Mayr, A.; Stankewitz, A.; Filippopulos, F.; Jahn, P.; Witkovsky, V.; Straube, A.; Schulz, E.
10.1101/2021.06.30.450591 — neuroscience — Posted on 2021-07-01
4005 Characterization of the Brassica napus flavonol synthase gene family reveals bifunctional flavonol synthases
Schilbert, H. M.; Schoene, M.; Baier, T.; Busche, M.; Viehoever, P.; Weisshaar, B.; Holtgraewe, D.
10.1101/2021.06.30.450533 — plant biology — Posted on 2021-07-01
4006 A 3D gene expression atlas of the floral meristem based on spatial reconstruction of single nucleus RNA sequencing data
Neumann, M.; Xu, X.; Smaczniak, C.; Schumacher, J.; Yan, W.; Greb, T.; Bluthgen, N.; Jonsson, H.; Traas, J.; Kaufmann, K.; Muino, J. M.
10.1101/2021.06.30.450319 — plant biology — Posted on 2021-07-01
4009 Susceptibility to diet induced obesity at thermoneutral conditions is independent of UCP1
Dieckmann, S.; Strohmeyer, A.; Willershaeuser, M.; Maurer, S.; Wurst, W.; Marschall, S.; Hrabe de Angelis, M.; Kuehn, R.; Worthmann, A.; Fuh, M. M.; Heeren, J.; Koehler, N.; Pauling, J.; Klingenspor, M.
10.1101/2021.06.30.450595 — physiology — Posted on 2021-07-01
4010 Toxicological profile of umbilical cord blood-derived small extracellular vesicles
Rodrigues, S. C.; Cardoso, R. M. S.; Gomes, C. F.; Duarte, F. V.; Freire, P. C.; Neves, R.; Simoes-Correia, J.
10.1101/2021.06.30.450343 — pharmacology and toxicology — Posted on 2021-07-01
4011 Conversion of cancer-associated fibroblasts from pro- to antitumor improves the sensitivity of pancreatic cancer to chemotherapeutics
Iida, T.; Mizutani, Y.; Esaki, N.; Ponik, S. M.; Burkel, B. M.; Weng, L.; Kuwata, K.; Masamune, A.; Ishihara, S.; Haga, H.; Kataoka, K.; Mii, S.; Shiraki, Y.; Ishikawa, T.; Ohno, E.; Kawashima, H.; Hirooka, Y.; Fujishiro, M.; Takahashi, M.; Enomoto, A.
10.1101/2021.06.29.450327 — cancer biology — Posted on 2021-07-01
4012 Intratumoral Heterogeneity Promotes Collective Cancer Invasion Through NOTCH1 Variation
Torab, P.; Yan, Y.; Ahmed, M.; Yamashita, H.; Warrick, J.; Raman, J.; DeGraff, D. J.; Wong, P.
10.1101/2021.06.30.450540 — cancer biology — Posted on 2021-07-01
4013 Evaluation of FRET X for Single-Molecule Protein Fingerprinting
de Lannoy, C.; Filius, M.; van Wee, R.; Joo, C.; de Ridder, D.
10.1101/2021.06.30.450512 — biophysics — Posted on 2021-07-01
4016 The Genome Sequence Archive Family: Towards Explosive Data Growth and Diverse Data Types
Chen, T.; Chen, X.; Zhang, S.; Zhu, J.; Tang, B.; Wang, A.; Dong, L.; Zhang, Z.; Yu, C.; Sun, Y.; Chi, L.; Chen, H.; Zhai, S.; Sun, Y.; Lan, L.; Zhang, X.; Xiao, J.; Bao, Y.; Wang, Y.; Zhang, Z.; Zhao, W.
10.1101/2021.06.29.449849 — bioinformatics — Posted on 2021-07-01
4022 Epigenetic regulation clocks the multigenerational olfactory imprinting in C. elegans
Garcia, M. E.; Fernandes de Abreu, D. A.; Gruet, A.; Blanchard, M.-P.; Baranger, K.; Clovis, Y.; Feron, F.; Remy, J.-J.
10.1101/2021.06.30.449753 — animal behavior and cognition — Posted on 2021-07-01
4025 Penetrance estimation of SORL1 loss-of-function variants using a family-based strategy adjusted on APOE genotypes suggest a non-monogenic inheritance
Schramm, C.; Charbonnier, C.; Zarea, A.; Lacour, M.; Wallon, D.; CNRMAJ collaborators, ; Boland, A.; Deleuze, J.-F.; Olaso, R.; Alarcon, F.; Campion, D.; Nuel, G.; Nicolas, G.
10.1101/2021.06.30.450554 — genetics — Posted on 2021-07-01
4029 Promoting long-term forest landscape resilience in the Lake Tahoe basin
Abelson, E. S.; Reynolds, K. M.; White, A. M.; Long, J. W.; Maxwell, C.; Manley, P. N.
10.1101/2021.06.29.450434 — ecology — Posted on 2021-07-01
4032 Distinct repertoire expansion patterns during affinity maturation of antigen responding camelid-derived single-domain VHH antibody
Matsuda, T.; Akazawa-Ogawa, Y.; Komaba, L.-K.; Kiyose, N.; Miyazaki, N.; Mizuguchi, Y.; Fukuta, T.; Ito, Y.; Hagihara, Y.
10.1101/2021.06.29.449501 — immunology — Posted on 2021-07-01
4033 PET imaging studies to investigate functional expression of mGluR2 using mG2P001
Yuan, G.; Dhaynaut, M.; Guehl, N. J.; Ramesh, N.; Moon, S.-H.; Qu, X.; Poutiainen, P.; Afshar, S.; El Fakhri, G.; Brownell, A.-L.; Normandin, M. D.
10.1101/2021.06.29.450406 — neuroscience — Posted on 2021-07-01
4034 All-optical interrogation of neural circuits in behaving mice
Russell, L. E.; Dalgleish, H. W. P.; Nutbrown, R.; Gauld, O.; Herrmann, D.; Fisek, M.; Packer, A.; Hausser, M.
10.1101/2021.06.29.450430 — neuroscience — Posted on 2021-07-01
4039 A novel post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson's disease GBA-N370S dopamine neurons
Bogetofte, H.; Ryan, B. J.; Jensen, P.; Vergoossen, D. L. E.; Bogetofte Barnkob, M.; Kiani, L.; Chughtai, U.; Brandes, J.; Vowles, J. J.; Bunn, F.; Kilfeather, P.; Fernandes, H. J. R.; Caffrey, T.; Meyer, M.; Cowley, S. A.; Larsen, M. R.; Wade-Martins, R.
10.1101/2021.06.30.450333 — neuroscience — Posted on 2021-07-01
4040 Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice
Cudalbu, C.; Bady, P.; Lai, M.; Xin, L.; Gusyatiner, O.; Hamou, M.-F.; Lepore, M.; Brouland, J.-P.; Daniel, R. T.; Hottinger, A.; Hegi, M. E.
10.1101/2021.06.29.450408 — cancer biology — Posted on 2021-07-01
4047 Design, synthesis, and characterization of mG2P026 as a high contrast PET imaging ligand for metabotropic glutamate receptor 2
Yuan, G.; Dhaynaut, M.; Guehl, N. J.; Afshar, S.; Huynh, D.; Moon, S.-H.; Iyengar, S.; Kang, H. J.; Ondrechen, M. J.; El Fakhri, G.; Normandin, M. D.; Brownell, A.-L.
10.1101/2021.06.29.450249 — neuroscience — Posted on 2021-07-01
4048 Transcriptional profiling of sequentially generated septal neuron fates
Harwell, C. C.; Turrero Garcia, M.; Stegmann, S. K.; Lacey, T.; Reid, C. M.; Hrvatin, S.; Weinreb, C.; Adam, M. A.; Nagy, M. A.
10.1101/2021.06.29.450296 — neuroscience — Posted on 2021-07-01
4049 Prefrontal stimulation prior to motor sequence learning alters multivoxel patterns in the striatum and the hippocampus
Gann, M. A.; King, B. R.; Dolfen, N.; Veldman, M. P.; Davare, M.; Swinnen, S. P.; Mantini, D.; Robertson, E. M.; Albouy, G.
10.1101/2021.07.01.450671 — neuroscience — Posted on 2021-07-01
4050 Optogenetic tools for public goods control in Saccharomyces cerevisiae
Moreno Morales, N.; Patel, M. T.; Stewart, C. J.; Sweeney, K.; McClean, M. N.
10.1101/2021.06.28.450270 — bioengineering — Posted on 2021-07-01
4051 Mapping of the fibrinogen-binding site on the staphylocoagulase C-terminal repeat region
Maddur, A. A.; Voehler, M. W.; Panizzi, P.; Meiler, J.; Bock, P. E.; Verhamme, I. M.
10.1101/2021.06.29.450373 — biochemistry — Posted on 2021-07-01
4053 B1-type cyclins control microtubule organization during cell division in Arabidopsis
Motta, M. R.; Zhao, X.; Pastuglia, M.; Belcram, K.; Roodbarkelari, F.; Komaki, M.; Harashima, H.; Komaki, S.; Bulankova, P.; Heese, M.; Riha, K.; Bouchez, D.; Schnittger, A.
10.1101/2021.06.29.450310 — cell biology — Posted on 2021-07-01
4054 Blocking mitophagy does not improve fuel ethanol production in Saccharomyces cerevisiae
Eliodorio, K. P.; de Gois e Cunha, G. C.; White, B. A.; Patel, D. H.; Zhang, F.; Hettema, E.; Basso, T. O.; Gombert, A.; Raghavendran, V.
10.1101/2021.06.29.450456 — microbiology — Posted on 2021-07-01
4055 Logical modeling: Combining manual curation and automated parameterization to predict drug synergies
Flobak, A.; Zobolas, J.; Vazquez, M.; Steigedal, T. S.; Thommesen, L.; Grislingas, A.; Niederdorfer, B.; Folkesson, E.; Kuiper, M.
10.1101/2021.06.28.450165 — systems biology — Posted on 2021-07-01
4056 An open-access volume electron microscopy atlas of whole cells and tissues
Xu, C. S.; Pang, S.; Shtengel, G.; Müller, A.; Ritter, A. T.; Hoffman, H. K.; Takemura, S.-y.; Lu, Z.; Pasolli, H. A.; Iyer, N.; Chung, J.; Bennett, D.; Weigel, A. V.; Freeman, M.; van Engelenburg, S. B.; Walther, T. C.; Farese, R. V.; Lippincott-Schwartz, J.; Mellman, I.; Solimena, M.; Hess, H.
10.1101/2020.11.13.382457 — cell biology — Posted on 2021-07-01
4058 Mycobacterium tuberculosis SufR Responds to Nitric oxide via its 4Fe-4S cluster and Regulates Fe-S cluster Biogenesis for Persistence in Mice
Anand, K.; Tripathi, A.; Shukla, K.; Malhotra, N.; Jamithireddy, A.; Jha, R. K.; Chaudhury, S. N.; Rajmani, R. S.; Ramesh, A.; Nagaraja, V.; Gopal, B.; Nagaraju, G.; Seshasayee, A. S. N.; Singh, A.
10.1101/2020.08.10.245365 — microbiology — Posted on 2021-07-01
4063 Synaptic targets of photoreceptors specialized to detect color and skylight polarization in Drosophila
Kind, E.; Longden, K. D.; Nern, A.; Zhao, A.; Sancer, G.; Flynn, M.; Laughland, C.; Gezahegn, B.; Ludwig, H.; Thomson, A.; Obrusnik, T.; Alarcon, P. G.; Dionne, H.; Bock, D. D.; Rubin, G. M.; Reiser, M. B.; Wernet, M. F.
10.1101/2021.05.17.444480 — neuroscience — Posted on 2021-07-01
4064 Rare long-range cortical connections enhance information processing
Deco, G.; Sanz Perl, Y.; Vuust, P.; Tagliazucchi, E.; Kennedy, H.; Kringelbach, M. L.
10.1101/2021.02.08.430236 — neuroscience — Posted on 2021-07-01
4065 Different underlying mechanisms for high and low arousal in probabilistic learning in humans
Ciria, L. F.; Suarez-Pinilla, M.; Williams, A. G.; Jagannathan, S. R.; Sanabria, D.; Bekinschtein, T. A.
10.1101/2021.02.26.431959 — neuroscience — Posted on 2021-07-01
4066 DiversityScanner: Robotic discovery of small invertebrates with machine learning methods
Wuehrl, L.; Pylatiuk, C.; Giersch, M.; Lapp, F.; von Rintelen, T.; Balke, M.; Schmidt, S.; Cerretti, P.; Meier, R.
10.1101/2021.05.17.444523 — zoology — Posted on 2021-07-01
4068 Validation and classification of RNA binding proteins identified by mRNA interactome capture
Vaishali, V.; Dimitrova-Paternoga, L.; Haubrich, K.; Sun, M.; Ephrussi, A.; Hennig, J.
10.1101/2021.02.02.429302 — biochemistry — Posted on 2021-07-01
4069 Primary saturation of α,β-unsaturated carbonyl containing fatty acids does not abolish electrophilicity
Snyder, N. W.; O'Brien, J.; Singh, B.; Buchan, G.; Arroyo, A. D.; Liu, X.; Bostwick, A.; Varner, E. L.; Angajala, A.; Sobol, R. W.; Blair, I. A.; Mesaros, C. A.; Wendell, S. G.
10.1101/2020.09.24.311985 — biochemistry — Posted on 2021-07-01