bioRxiv directory

1 Plasma amyloid beta ratios in autosomal dominant Alzheimers disease: the influence of genotype

O'Connor, A.; Pannee, J.; Poole, T.; Arber, C.; Portelius, E.; Abel, E.; Swift, I. J.; Heslegrave, A.; Willumsen, N.; Rice, H.; Weston, P. S.; Ryan, N. S.; Polke, J.; Nicholas, J.; mead, s. H.; Wray, S.; Chavez Gutierrez, L.; Frost, C.; Blennow, K.; Zetterberg, H.; Fox, N. C.

10.1101/2021.02.11.430756 — neuroscience — Posted on 2021-02-12

2 Re-treatment with direct-acting antivirals policy is needed to eliminate Hepatitis C among persons who inject drugs

Tatara, E.; Gutfraind, A.; Collier, N. T.; Echevarria, D.; Cotler, S. J.; Major, M.; Ozik, J.; Dahari, H.; Boodram, B.

10.1101/653196 — epidemiology — Posted on 2021-02-22

3 Ownership, Coverage, Utilisation and Maintenance of Long-lasting insecticidal nets in Three Health Districts in Cameroon: A Cross-Sectional Study

Cho, F. N.; Fru, P. N.; Cho, B. M.; Munguh, S. F.; Jokwi, P. K.; Ngah, Y. E.; Fru, C. N.; Tassang, A. N.; Fon, P. N.; Ekobo, A. S.

10.1101/465005 — epidemiology — Posted on 2021-02-22

4 Destabilization of β-cell FIT2 by saturated fatty acids contribute to ER stress and diabetes

Zheng, X.; Ho, Q. W. C.; Chua, M.; Stelmashenko, O.; Muralidharan, S.; Torta, F. T.; Chew, E. G. Y.; Lian, M. M.; Foo, J. N.; Wenk, M. R.; Silver, D. L.; Berggren, P.-O.; Ali, Y.

10.1101/2021.02.28.433270 — biochemistry — Posted on 2021-02-28

5 Novel newt regeneration genes regulate Wingless signaling to restore patterning in Drosophila eye

Mehta, A. S.; Deshpande, P.; Chimata, A. V.; Singh, A.

10.1101/2021.02.28.433269 — developmental biology — Posted on 2021-02-28

6 Collagen polarization provides a structural memory for the elongation of epithelial anlage.

Katsuno-Kambe, H.; Teo, J. L.; Ju, R. J.; Hudson, J. E.; Stehbens, S. J.; Yap, A. S.

10.1101/2021.02.28.433274 — cell biology — Posted on 2021-02-28

7 Highly social pinyon jays, but not less social Clark's nutcrackers, modify their food-storing behaviour when observed by a heterospecific

Vernouillet, A.; Clary, D.; Kelly, D. M.

10.1101/2021.02.28.433225 — animal behavior and cognition — Posted on 2021-02-28

8 Histone demethylome map reveals combinatorial gene regulatory functions in embryonic stem cells

Kumar, Y.; Tripathi, P.; Mehravar, M.; Zhang, Z.; Dakle, P.; Bullen, M. J.; Pandey, V. K.; Hathiwala, D.; Kerenyi, M.; Woo, A.; Ghamari, A.; Cantor, A. B.; Wong, L. H.; Kim, J.; Glass, K.; Yuan, G.-C.; Pinello, L.; Orkin, S. H.; Das, P. P.

10.1101/2020.08.27.269514 — genomics — Posted on 2021-02-28

9 Chronic Pb2+ exposure causes theta-band hypersynchrony disrupting sensory motor gating and exacerbating absence seizures

Schultheiss, N. W.; McGlothan, J. L.; Guilarte, T. R.; Allen, T. A.

10.1101/2020.06.30.181149 — neuroscience — Posted on 2021-02-28

10 Territory-level temperature influences settlement decisions, breeding phenology and productivity in three forest passerine birds

Shutt, J. D.; Bell, S. C.; Bell, F.; Castello, J.; El Harouchi, M.; Burgess, M. D.

10.1101/2021.01.31.429009 — ecology — Posted on 2021-02-28

11 Gut microbial structural variations as determinants of human bile acid metabolism

Wang, D.; Doestzada, M.; Chen, L.; Andreu-Sanchez, S.; van den Munckhof, I. C. L.; Augustijn, H.; Koehorst, M.; Bloks, V. W.; Riksen, N. P.; Rutten, J. H. W.; Netea, M. G.; Zhernakova, A.; Kuipers, F.; Fu, J.

10.1101/2021.02.28.432952 — microbiology — Posted on 2021-02-28

12 Somatosensory processing deficits and altered cortico-hippocampal connectivity in Shank3b-/- mice

Balasco, L.; Pagani, M.; Pangrazzi, L.; Schlosman, E.; Mattioni, L.; Galbusera, A.; Provenzano, G.; Gozzi, A.; Bozzi, Y.

10.1101/2021.02.28.433258 — neuroscience — Posted on 2021-02-28

13 Donor-derived vasculature is required to support neocortical cell grafts after stroke

Krzyspiak, J.; Yan, J.; Ghosh, H.; Galinski, B.; Lituma, P. J.; Alvina, K.; Washburn, S.; Gronska-Peski, M.; Tai, Y. D.; McDermott, K.; Zukin, S.; Weiser, D.; Castillo, P. E.; Khodakhah, K.; Hebert, J.

10.1101/2021.02.27.433204 — neuroscience — Posted on 2021-02-28

14 Hybrid dedicated and distributed coding in PMd/M1 provides separation and interaction of bilateral arm signals

Dixon, T. C.; Merrick, C. M.; Wallis, J. D.; Ivry, R. B.; Carmena, J. M.

10.1101/2020.09.23.310664 — neuroscience — Posted on 2021-02-28

15 Poly (I:C)-induced maternal immune activation modifies ventral hippocampal regulation of stress reactivity: prevention by environmental enrichment

Zhao, X.; Mohammed, R.; Tran, H.; Erickson, M.; Kentner, A. C.

10.1101/2021.01.21.427695 — neuroscience — Posted on 2021-02-28

16 Protein Design and Variant Prediction Using Autoregressive Generative Models

Shin, J.-E.; Riesselman, A. J.; Kollasch, A. W.; McMahon, C.; Simon, E.; Sander, C.; Manglik, A.; Kruse, A. C.; Marks, D. S.

10.1101/757252 — systems biology — Posted on 2021-02-28

17 Rapid stress hardening in the Antarctic midge improves male fertility by increasing courtship success and preventing the decline of accessory gland proteins following cold exposure

Ajayi, O. M.; Finch, G.; Lee, R. E.; Denlinger, D. L.; Benoit, J. B.

10.1101/2021.02.27.432016 — physiology — Posted on 2021-02-28

18 VPRBP functions downstream of the androgen receptor and OGT to restrict p53 activation in prostate cancer

Poulose, N.; Polonski, A.; Forsythe, N.; Gregg, G.; Maguire, S.; Fuchs, M.; Minner, S.; McDade, S. S.; Mills, I.

10.1101/2021.02.28.433236 — cancer biology — Posted on 2021-02-28

19 MAPK Pathway Inhibition as A Rational Therapeutic Strategy for MiR-138-5p/PAQR3 Dysregulation-mediated Epirubicin Resistance in Triple-negative Breast Cancer

Huang, J.; Xiao, Y.; Zeng, S.; Wang, X.; Li, H.; Xiang, T.; Kong, L.; Ren, G.

10.1101/2021.02.28.433242 — cancer biology — Posted on 2021-02-28

20 Informative Regions In Viral Genomes

Reyes, A.; Moreno-Gallego, J. L.

10.1101/2021.02.28.433233 — bioinformatics — Posted on 2021-02-28

21 MASiVar: Multisite, Multiscanner, and Multisubject Acquisitions for Studying Variability in Diffusion Weighted Magnetic Resonance Imaging

Cai, L. Y.; Yang, Q.; Kanakaraj, P.; Nath, V.; Newton, A. T.; Edmonson, H. A.; Luci, J.; Conrad, B. N.; Price, G. R.; Hansen, C. B.; Kerley, C. I.; Ramadass, K.; Yeh, F.-C.; Kang, H.; Garyfallidis, E.; Descoteaux, M.; Rheault, F.; Schilling, K. G.; Landman, B. A.

10.1101/2020.12.03.408567 — bioengineering — Posted on 2021-02-28

22 HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver

Deans, J. R.; Deol, P.; Titova, N.; Radi, S. H.; Vuong, L. M.; Evans, J. R.; Pan, S.; Fahrmann, J.; Yang, J.; Hammock, B. D.; Fiehn, O.; Fekry, B.; Eckel-Mahan, K.; Sladek, F. M.

10.1101/2021.02.28.433261 — genomics — Posted on 2021-02-28

23 Tetraploidy accelerates adaptation under drug-selection in a fungal pathogen

Avramovska, O.; Rego, E.; Hickman, M. A.

10.1101/2021.02.28.433243 — evolutionary biology — Posted on 2021-02-28

24 Is bigger always better? Neither body size nor aggressive behavior are good predictors to measure the degree of specialization of hummingbird interaction networks in rocky outcrops

Claudino, R. M.; Antonini, Y.; Martins, C.; Beirao, M.; Braga, E. M.; Azevedo, C. S.

10.1101/2021.02.27.433160 — ecology — Posted on 2021-02-28

25 PDX1 directs a core developmentally and evolutionarily conserved gene program in the pancreatic islet

Yang, X.; Raum, J. C.; Kim, J.; Yu, R.; Yang, J.; Rice, G.; Li, C.; Won, K.-J.; Stoffers, D. A.; Stanescu, D. E.

10.1101/2021.02.28.433241 — developmental biology — Posted on 2021-02-28

26 Development of the foregut in Katharina tunicata (Mollusca; Polyplacophora)

Biggar, B. S.

10.1101/2021.02.28.433208 — developmental biology — Posted on 2021-02-28

27 A role for Gcn5 in heterochromatin structure, gene silencing and NER at the HML locus in budding yeast

Chen, H.; Zhang, L.; Wang, Q.; He, C.; Dender, L. F.; Gong, F.

10.1101/2021.02.28.433071 — molecular biology — Posted on 2021-02-28

28 The gene expression profile of the song control nucleus HVC shows sex specificity, hormone responsiveness, and species specificity among songbirds

Ko, M.-C.; Frankl-Vilches, C.; Bakker, A.; Gahr, M.

10.1101/2021.02.28.432133 — molecular biology — Posted on 2021-02-28

29 Alanine cross-feeding determines Escherichia coli colony growth dynamics

Diaz-Pascual, F.; Lempp, M.; Nosho, K.; Jeckel, H.; Jo, J. K.; Neuhaus, K.; Hartmann, R.; Jelli, E.; Hansen, M. F.; Dietrich, L. E. P.; Link, H.; Drescher, K.

10.1101/2021.02.28.433255 — microbiology — Posted on 2021-02-28

30 Poly(rC)-binding protein 1 limits hepatitis C virus assembly and egress

Cousineau, S. E.; Sagan, S. M.

10.1101/2021.02.28.433252 — microbiology — Posted on 2021-02-28

31 Visual stimulation with blue wavelength light drives V1 effectively eliminating stray light contamination during two-photon calcium imaging

Kuznetsova, T.; Antos, K.; Malinina, E.; Papaioannou, S.; Medini, P.

10.1101/2021.02.27.433182 — neuroscience — Posted on 2021-02-28

32 Pathology dynamics in healthy-toxic protein interaction and the multiscale analysis of neurodegenerative diseases

Pal, S.; Melnik, R.

10.1101/2021.02.27.433219 — neuroscience — Posted on 2021-02-28

33 Enhancing oscillations in intracranial electrophysiological recordings with data-driven spatial filters

Schaworonkow, N.; Voytek, B.

10.1101/2021.02.26.433127 — neuroscience — Posted on 2021-02-28

34 Increased region of surround stimulation enhances contextual feedback and feedforward processing in human V1

Revina, Y.; Petro, L. S.; Denk-Florea, C. B.; Rao, I. S.; Muckli, L.

10.1101/2021.02.27.433018 — neuroscience — Posted on 2021-02-28

35 Identification of Kinases Activated by Multiple Pro-Angiogenic Growth Factors

Gruver, J. S.; Rata, S.; Peshkin, L.; Kirschner, M. W.

10.1101/2021.02.28.433132 — systems biology — Posted on 2021-02-28

36 Data variability in standardised cell culture experiments

Reddin, I.; Fenton, T. R.; Wass, M. N.; Michaelis, M.

10.1101/2021.02.27.433153 — pharmacology and toxicology — Posted on 2021-02-28

37 Whole-genome doubling-aware copy number phylogenies for cancer evolution with MEDICC2

Petkovic, M.; Watkins, T. B.; Colliver, E. C.; Laskina, S.; Swanton, C.; Haase, K.; Schwarz, R. F.

10.1101/2021.02.28.433227 — bioinformatics — Posted on 2021-02-28

38 The intestinal microbiota-driven dopamine level influences social interaction and innate color preference in zebrafish larvae

Wang, J.; Zheng, F.; Yin, L.; Shi, S.; hu, b.; Zheng, L.

10.1101/2021.02.26.433134 — animal behavior and cognition — Posted on 2021-02-28

39 How does the magnitude of genetic variation affect eco-evolutionary dynamics in character displacement?

Morita, K.; Yamamichi, M.

10.1101/2021.02.26.432976 — ecology — Posted on 2021-02-28

40 DLL4 and PDGF-BB regulate migration of human iPSC-derived skeletal myogenic progenitors

Ferrari, G.; Choi, S.; Moyle, L. A.; Mackinlay, K.; Naouar, N.; Wells, C.; Muntoni, F.; Tedesco, F. S.

10.1101/2021.02.28.431778 — cell biology — Posted on 2021-02-28

41 Normalizing and denoising protein expression data from droplet-based single cell profiling

Mule, M. P.; Martins, A. J.; Tsang, J. S.

10.1101/2020.02.24.963603 — bioinformatics — Posted on 2021-02-28

42 Faecal metabarcoding reveals pervasive long-distance impacts of garden bird feeding

Shutt, J. D.; Trivedi, U. H.; Nicholls, J. A.

10.1101/2021.01.31.429015 — ecology — Posted on 2021-02-28

43 A unicellular walker embodies a finite state machine

Larson, B. T.; Garbus, J.; Pollack, J. B.; Marshall, W. F.

10.1101/2021.02.26.433123 — cell biology — Posted on 2021-02-28

44 The Epstein-Barr virus ubiquitin deconjugase BPLF1 regulates the activity of Topoisomerase II during virus replication

Li, J.; Nagy, N.; Liu, J.; Gupta, S.; Frisan, T.; Hennig, T.; Cameron, D. P.; Baranello, L.; Masucci, M. G.

10.1101/2021.02.26.433008 — microbiology — Posted on 2021-02-28

45 Sustained antibody response to ZIKV infection induced by NS1 protein is accompanied by the progressive appearance of autoreactive antibodies and cross-reactive B cell clones.

Cavazzoni, C. B.; Bozza, V. B.; Tostes, L.; Maia, B.; Mesin, L.; Schiepers, A.; Ersching, J.; Neris, R. L.; Conde, J. N.; Coleho, D. R.; Conde, L.; Paula-Neto, H. A.; Lima, T. M.; Alvim, R. G. F.; Castilho, L. R.; Mohana-Borges, R.; Assuncao-Miranda, I.; Nobrega, A.; Victora, G. D.; Vale, A. M.

10.1101/2020.12.24.423863 — immunology — Posted on 2021-02-28

46 Concurrent feature-specific reactivation within the hippocampus and neocortex facilitates episodic memory retrieval

Bone, M. B.; Buchsbaum, B. R.

10.1101/2021.02.28.433226 — neuroscience — Posted on 2021-02-28

47 Ultra-high field (7T) functional magnetic resonance imaging in amyotrophic lateral sclerosis: a pilot study

Barry, R.; Babu, S.; Anteraper, S.; Triantafyllou, C.; Keil, B.; Rowe, O.; Rangaprakash, D.; Paganoni, S.; Lawson, R.; Dheel, C.; Cernasov, P.; Rosen, B.; Ratai, E.-M.; Atassi, N.

10.1101/2020.12.02.408278 — neuroscience — Posted on 2021-02-28

48 Interaural Time Difference Tuning in the Rat Inferior Colliculus is Predictive of Behavioral Sensitivity

Li, K.; Rajendran, V. G.; Mishra, A. P.; Chan, C. H. K.; Schnupp, J. W. H.

10.1101/2021.02.21.432131 — neuroscience — Posted on 2021-02-28

49 MASiVar: Multisite, Multiscanner, and Multisubject Acquisitions for Studying Variability in Diffusion Weighted Magnetic Resonance Imaging

10.1101/2020.12.03.408567 — bioengineering — Posted on 2021-02-28

50 Neuronal activity patterns regulate BDNF expression in cortical neurons via synaptic connections and calcium signaling

Miyasaka, Y.; Yamamoto, N.

10.1101/2021.02.28.433239 — neuroscience — Posted on 2021-02-28

51 Post-transcriptional dysregulation in autism, schizophrenia and bipolar disorder

Wang, Y.; Liu, L.; Lin, M.

10.1101/2021.02.28.433176 — genomics — Posted on 2021-02-28

52 Allelic and Genotypic Frequencies of NAT2, CYP2E1 and AADAC genes in a cohort of Peruvian Tuberculosis Patients

Levano, K. S.; Jaramillo-Valverde, L.; Tarazona, D. D.; Sanchez, C.; Capristano, S.; Solari, L.; Mendoza-Ticona, A.; Soto, A.; Rojas, C.; Zegarra-Chapoñan, R.; Guio, H.

10.1101/2021.02.27.433209 — genetics — Posted on 2021-02-28

53 CRYPTOCHROME suppresses the circadian proteome and promotes protein homeostasis

Wong, D. C. S.; Seinkmane, E.; Stangherlin, A.; Zeng, A.; Rzechorzek, N. M.; Beale, A. D.; Day, J.; Reed, M.; Peak-Chew, S. Y.; Styles, C. T.; Edgar, R. S.; Putker, M.; O'Neill, J. S.

10.1101/2020.05.16.099556 — cell biology — Posted on 2021-02-28

54 De novo purine nucleotide biosynthesis mediated by amidophosphoribosyl transferase is required for conidiation and essential for the successful host colonization of Magnaporthe oryzae

Aron, O.; Wang, M.; Guo, J.; Otieno, J. F.; Zuriegat, Q.; Lu, S.; Wang, Z.; Tang, W.

10.1101/2021.02.28.433215 — molecular biology — Posted on 2021-02-28

55 Microbial diversity in tropical marine sediments assessed using culture-dependent and culture-independent techniques

Demko, A. M.; Patin, N. V.; Jensen, P. R.

10.1101/2021.02.27.433211 — microbiology — Posted on 2021-02-28

56 Integration of phenomics and transcriptomics data to reveal drivers of inflammatory processes in the skin

Batra, R.; Garzorz-Stark, N.; Lauffer, F.; Jargosch, M.; Pilz, C.; Roenneberg, S.; Schaebitz, A.; Boehner, A.; Seiringer, P.; Thomas, J.; Fereydouni, B.; Kutkaite, G.; Menden, M.; Tsoi, L. C.; Gudjonsson, J. E.; Theis, F. F.; Biedermann, T.; Schmidt-Weber, C. B.; Mueller, N.; Eyerich, S.; Eyerich, K.

10.1101/2020.07.25.221309 — immunology — Posted on 2021-02-28

57 Circumpolar peoples and their languages: lexical and genomic data suggest ancient Chukotko-Kamchatkan-Nivkh and Yukaghir-Samoyedic connections

Starostin, G.; Altınısık, N. E.; Zhivlov, M.; Changmai, P.; Flegontova, O.; Spirin, S. A.; Zavgorodnii, A.; Flegontov, P.; Kassian, A. S.

10.1101/2021.02.27.433193 — genomics — Posted on 2021-02-28

58 A partially sex-reversed giant kelp sheds light into the mechanisms of sexual differentiation in a UV sexual system

Mueller, D.; Gachet, E.; Godfroy, O.; Gueno, J.; Cossard, G.; Kunert, M.; Peters, A. F.; Westermeier, R. H.; Boland, W.; Cock, J. M.; Lipinska, A.; Coelho, S. M.

10.1101/2021.02.28.433149 — evolutionary biology — Posted on 2021-02-28

59 Beyond taxonomic identification: integration of ecological responses to a soil bacterial 16S rRNA gene database.

Jones, B. A.; Goodall, T.; George, P. B. L.; Gweon, H. s.; Puissant, J.; Read, D.; Emmett, B.; Robinson, D.; Jones, D.; Griffiths, R.

10.1101/843847 — microbiology — Posted on 2021-02-28

60 Mapping yeast mitotic 5' resection at base resolution reveals the sequence and positional dependence of nucleases in vivo

Bazzano, D.; Lomonaco, S.; Wilson, T. E.

10.1101/2021.02.27.433206 — genetics — Posted on 2021-02-28

61 Integration of phenomics and transcriptomics data to reveal drivers of inflammatory processes in the skin

Batra, R.; Garzorz-Stark, N.; Lauffer, F.; Jargosch, M.; Pilz, C.; Roenneberg, S.; Schaebitz, A.; Boehner, A.; Seiringer, P.; Thomas, J.; Fereydouni, B.; Tsoi, L. C.; Gudjonsson, J. E.; Theis, F. F.; Biedermann, T.; Schmidt-Weber, C. B.; Mueller, N.; Eyerich, S.; Eyerich, K.

10.1101/2020.07.25.221309 — immunology — Posted on 2021-02-28

62 Unraveling the role of MADS transcription factor complexes in apple tree dormancy using sequential DAP-seq

Falavigna, V. d. S.; Severing, E.; Lai, X.; Estevan, J.; Farrera, I.; Hugouvieux, V.; Revers, L. F.; Zubieta, C.; Coupland, G.; Costes, E.; Andres, F.

10.1101/2021.02.21.431301 — plant biology — Posted on 2021-02-28

63 A synthetic RNA-mediated evolution system in yeast

Jensen, E. D.; Laloux, M.; Lehka, B. J.; Pedersen, L. E.; Jakociunas, T.; Jensen, M. K.; Keasling, J. D.

10.1101/2021.02.27.433199 — bioengineering — Posted on 2021-02-28

64 A new murine Rpl5 (uL18) mutation provides a unique model of variably penetrant Diamond Blackfan Anemia

Yu, L.; Lemay, P.; Ludlow, A.; Guyot, M.-C.; Jones, M.; Mohamed, F. F.; Saroya, G.-A.; Panaretos, C.; Schneider, E.; Wang, Y.; Myers, G.; Khoriaty, R.; Li, Q.; Franceschi, R.; Engel, J. D.; Kaartinen, V.; Rothstein, T. L.; Justice, M. J.; Kibar, Z.; Singh, S. A.

10.1101/2021.02.27.430069 — developmental biology — Posted on 2021-02-28

65 Brazil Nut Effect Drives Pattern Formation in Early Mammalian Embryos

guo, z.; Yao, J.; Zheng, X.; Cao, J.; Guo, S.; Qin, D.; Gao, Z.; Tan, M.; Wang, B.; Meng, F.; Zhang, J.; Chang, Z.; Li, L.; Du, J.; Fan, Y.

10.1101/2021.02.26.433068 — developmental biology — Posted on 2021-02-28

66 Comprehensive Profiling of Plasma Exosomes Using Data Independent Acquisitions, New Tools for Aging Cohort Studies

Patel, S. K.; Bruderer, R.; Basisty, N.; Bons, J.; Desprez, P.-Y.; Neri, F.; Reiter, L.; Campisi, J.; Schilling, B.

10.1101/2021.02.27.433188 — cell biology — Posted on 2021-02-28

67 G9a and Sirtuin6 epigenetically modulate host cholesterol accumulation to facilitate mycobacterial survival

Prakhar, P.; Bhatt, B.; Mukherjee, T.; Lohia, G. K.; Kolthur-Seetharam, U.; Sundaresan, N. R.; Rajmani, R. S.; Balaji, K. N.

10.1101/2021.02.27.433201 — microbiology — Posted on 2021-02-28

68 Allelic and Genotypic Frequencies of NAT2, CYP2E1 and AADAC genes in a cohort of Peruvian Tuberculosis Patients

Levano, K. S.; Jaramillo-Valverde, L.; Tarazona, D. D.; Sanchez, C.; Capristano, S.; Solari, L.; Mendoza-Ticona, A.; Soto, A.; Rojas, C.; Zegarra-Chapoñan, R.; Guio, H.

10.1101/2021.02.27.433209 — genetics — Posted on 2021-02-28

69 The scaffold-dependent function of RIPK1 in dendritic cells promotes injury-induced colitis

Moriwaki, K.; Park, C.; Koyama, K.; Balaji, S.; Kita, K.; Yagi, R.; Komazawa-Sakon, S.; Asuka, T.; Nakano, H.; Kamada, Y.; Miyoshi, E.; Chan, F.

10.1101/2021.02.27.433202 — immunology — Posted on 2021-02-28

70 Evaluation of the growth performance, physiological traits, antioxidant indices, and heat shock protein 70 to dietary supplementation of stinging nettle (Urtica dioica) in broilers exposed to chronic heat stress

Hosseinian, S. A.; Mirsaidi, S. M.

10.1101/2021.02.26.433121 — physiology — Posted on 2021-02-28

71 Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis

Tanner, L.; Single, A. B.; Bonghir, R. K. V.; Oomen, R.; Wallner, O.; Helleday, T.; Kalderen, C.; Egesten, A.

10.1101/2021.02.27.433075 — pharmacology and toxicology — Posted on 2021-02-28

72 The Parastagonospora nodorum necrotrophic effector SnTox5 targets the wheat gene Snn5 and facilitates entry into the leaf mesophyll

Kariyawasam, G.; Richards,, J. K.; Wyatt, N. A.; Running, K. L. D.; Xu, S. S.; Liu, Z.; Borowicz, P.; Faris, J. D.; Friesen, T. L. L.

10.1101/2021.02.26.433117 — pathology — Posted on 2021-02-28

73 Identification and characterization of a G-quadruplex structure in the pre-core promoter region of hepatitis B virus

Meier-Stephenson, V.; Badmalia, M. D.; Mrozowich, T.; Lau, K. C.; Schultz, S. K.; Gemmill, D. L.; Osiowy, C.; van Marle, G.; Coffin, C. S.; Patel, T. R.

10.1101/2021.01.19.427307 — biophysics — Posted on 2021-02-27

74 Cascading indirect genetic effects in a clonal vertebrate

Makowicz, A. M.; Bierbach, D.; Richardson, C.; Hughes, K. A.

10.1101/2021.02.27.433187 — animal behavior and cognition — Posted on 2021-02-28

75 A comprehensive fitness landscape model reveals the evolutionary history and future evolvability of eukaryotic cis-regulatory DNA sequences

Vaishnav, E. D.; de Boer, C. G.; Yassour, M.; Molinet, J.; Fan, L.; Adiconis, X.; Thompson, D. A.; Cubillos, F. A.; Levin, J. Z.; Regev, A.

10.1101/2021.02.17.430503 — genomics — Posted on 2021-02-27

76 A Fast Data-Driven Method for Genotype Imputation, Phasing, and Local Ancestry Inference: MendelImpute.jl

Chu, B. B.; Sobel, E. M.; Wasiolek, R.; Sinsheimer, J. S.; Zhou, H.; Lange, K.

10.1101/2020.10.24.353755 — genetics — Posted on 2021-02-27

77 Differential dominance of an allele of the Drosophila tbetah gene challenges standard genetic techniques

Damrau, C.; Colomb, J.; Brembs, B.

10.1101/504332 — genetics — Posted on 2021-02-27

78 Single-cell analysis identifies a key role for Hhip in murine coronal suture development

Holmes, G.; Gonzalez-Reiche, A. S.; Saturne, M.; Zhou, X.; Borges, A. C.; Shewale, B.; Zhang, B.; van Bakel, H.; Jabs, E. W.

10.1101/2021.02.27.433115 — developmental biology — Posted on 2021-02-27

79 A unicellular walker embodies a finite state machine

Larson, B. T.; Garbus, J.; Pollack, J. B.; Marshall, W. F.

10.1101/2021.02.26.433123 — cell biology — Posted on 2021-02-28

80 Bioorthogonal labeling of transmembrane proteins with non-canonical amino acids allows access to masked epitopes in live neurons

Bessa-Neto, D.; Kuhlemann, A.; Beliu, G.; Pecoraro, V.; Doose, S.; Retailleau, N.; Chevrier, N.; Perrais, D.; Sauer, M.; Choquet, D.

10.1101/2021.02.27.433189 — cell biology — Posted on 2021-02-28

81 Value Shapes Abstraction During Learning

Cortese, A.; Yamamoto, A.; Hashemzadeh, M.; Sepulveda, P.; Kawato, M.; De Martino, B.

10.1101/2020.10.29.361469 — neuroscience — Posted on 2021-02-27

82 Characterization of ethylene-inducible pedicel-fruit abscission zone formation in non-climacteric sweet cherry (Prunus avium L.)

Hewitt, S. L.; Kilian, B.; Koepke, T.; Abarca, J.; Whiting, M.; Dhingra, A.

10.1101/2020.09.05.284497 — plant biology — Posted on 2021-02-27

83 N-terminally truncated helper NLR NRG1C antagonizes immunity mediated by its full-length neighbors NRG1A and NRG1B

Wu, Z.; Tian, L.; Li, X.

10.1101/2021.01.27.428547 — plant biology — Posted on 2021-02-28

84 A unicellular walker embodies a finite state machine

Larson, B. T.; Garbus, J.; Pollack, J. B.; Marshall, W. F.

10.1101/2021.02.26.433123 — cell biology — Posted on 2021-02-27

85 Programmatic modeling for biological systems

Lubbock, A. L. R.; Lopez, C. F.

10.1101/2021.02.26.433125 — systems biology — Posted on 2021-02-27

86 Hyperspectral sensing of photosynthesis, stomatal conductance, and transpiration for citrus tree under drought condition

Zhou, J.-J.; Zhang, Y.-H.; Han, Z.-M.; Liu, X.-Y.; Jian, Y.-F.; Hu, C.; Dian, Y.-Y.

10.1101/2021.02.26.433135 — physiology — Posted on 2021-02-27

87 Discovering single nucleotide variants and indels from bulk and single-cell ATAC-seq

Massarat, A. R.; Sen, A.; Jaureguy, J.; Tyndale, S. T.; Fu, Y.; Erikson, G.; McVicker, G.

10.1101/2021.02.26.433126 — bioinformatics — Posted on 2021-02-27

88 Fiber density and matrix stiffness modulate distinct cell migration modes in a 3D stroma mimetic composite hydrogel

Hiraki, H. L.; Matera, D. L.; Wang, W. Y.; Zarouk, A. A.; Argento, A. E.; Buschhaus, J. M.; Humphries, B. A.; Luker, G. D.; Baker, B. M.

10.1101/2021.02.27.433190 — bioengineering — Posted on 2021-02-27

89 Quantitative consequences of protein carriers in immunopeptidomics and tyrosine phosphorylation MS2 analyses

Stopfer, L. E.; Conage-Pough, J. E.; White, F.

10.1101/2021.02.26.433124 — bioengineering — Posted on 2021-02-27

90 Murine norovirus capsid plasticity - Glycochenodeoxycholic acid stabilizes P domain dimers and triggers escape from antibody recognition

Creutznacher, R.; Maass, T.; Duelfer, J.; Feldmann, C.; Hartmann, V.; Knickmann, J.; Westermann, L. T.; Smith, T. J.; Uetrecht, C.; Mallagaray, A.; Peters, T.; Taube, S.

10.1101/2021.02.27.433148 — biochemistry — Posted on 2021-02-27

91 Structural basis of phosphorylation kinetics in the transcriptional activation domain (TAD) of c-Jun and insight of two new phosphorylation sites Ser58 and Thr62

Singh, V.; Kumar, A.; Bharti, S.; Jatav, A.

10.1101/2021.02.27.433150 — biochemistry — Posted on 2021-02-27

92 APOBEC Mutagenesis is Concordant Between Tumor and Viral Genomes in HPV Positive Head and Neck Squamous Cell Carcinoma

Faden, D. L.

10.1101/2021.02.27.433168 — genomics — Posted on 2021-02-27

93 Circulating miRNAs associated with bone mineral density in healthy adult baboons.

Quillen, E. E.; Foster, J.; Sheldrake, A.; Stainback, M.; Bredbenner, T. L.

10.1101/2021.02.27.433170 — genomics — Posted on 2021-02-27

94 Chromatin and transcriptomic profiling uncover dysregulation of the Tip60 HAT/HDAC2 epigenomic landscape in the neurodegenerative brain

Beaver, M.; Karisetty, B. C.; Zhang, H.; Bhatnagar, A.; Armour, E.; Parmar, V.; Brown, R.; Xiang, M.; Elefant, F.

10.1101/2021.02.27.433179 — genomics — Posted on 2021-02-27

95 Flor yeasts rewire the central carbon metabolism during wine alcoholic fermentation

Peltier, E.; Vion, C.; Abou Saada, O.; Friedrich, A.; Schacherer, J.; Marullo, P.

10.1101/2021.02.27.433177 — genetics — Posted on 2021-02-27

96 A de novo paradigm for male infertility

Oud, M. S.; Smits, R. M.; Smith, H. E.; Mastrorosa, F. K.; Holt, G. S.; Houston, B. J.; de Vries, P. F.; Alobaidi, B. K.; Batty, L. E.; Ismail, H.; Greenwood, J.; Sheth, H.; Mikulasova, A.; Astuti, G.; Gilissen, C. S.; McEleny, K.; Turner, H.; Coxhead, J.; Cockell, S. J.; Braat, D.; Fleischer, K.; D'Hauwers, K.; Schaafsma, E.; GEMINI Consortium, ; Nagirnaja, L.; Conrad, D.; Friedrich, C.; Kliesch, S.; Aston, K. I.; Riera-Escamilla, A.; Krausz, C. G.; Gonzaga-Jauregui, C.; Santibanez-Koref, M.; Elliott, D.; Vissers, L.; Tüttelmann, F.; O'Bryan, M.; Ramos, L.; Xavier, M. J.; van der Heijden, G

10.1101/2021.02.27.433155 — genetics — Posted on 2021-02-27

97 Novel epitopes of human monoclonal antibodies targeting the influenza virus N1 neuraminidase

Kirkpatrick Roubidoux, E.; McMahon, M.; Carreno, J. M.; Capuano, C.; Jiang, K.; Simon, V.; van Bakel, H.; Wilson, P.; Krammer, F.

10.1101/2021.02.26.433142 — microbiology — Posted on 2021-02-27

98 Amplicon sequence variants artificially split bacterial genomes into separate clusters

Schloss, P. D.

10.1101/2021.02.26.433139 — microbiology — Posted on 2021-02-27

99 Protection from lethal Clostridioides difficile infection via intraspecies competition for co-germinant

Leslie, J. L.; Jenior, M. L.; Vendrov, K. C.; Standke, A.; Barron, M. R.; O'Brien, T. J.; Unverdorben, L.; Thaprawat, P.; Bergin, I. L.; Schloss, P. D.; Young, V. B.

10.1101/2021.02.26.433146 — microbiology — Posted on 2021-02-27

100 Identification of a chromosomally-encoded sucrose operon-like gene cluster in Vibrio parahaemolyticus strain PH05 isolated from Negros Island, Philippines

De Mesa, C. A. E.; Mendoza, R. M.; de la Pena, L. D.; Amar, E. C.; Saloma, C. P.

10.1101/2021.02.27.433172 — microbiology — Posted on 2021-02-27

101 Downsizing in plants - UV induces pronounced morphological changes in cucumber in the absence of stress

Qian, M.; Rosenqvist, E.; Prinsen, E.; Pescheck, F.; Flygare, A.-M.; Kalbina, I.; Jansen, M. A. K.; Strid, A.

10.1101/2021.02.27.432481 — plant biology — Posted on 2021-02-27

102 DeCiFering the elusive cancer cell fraction in tumor heterogeneity and evolution

Satas, G.; Zaccaria, S.; El-Kebir, M.; Raphael, B.

10.1101/2021.02.27.429196 — bioinformatics — Posted on 2021-02-27

103 Representation learning applications in biological sequence analysis

Iuchi, H.; Matsutani, T.; Yamada, K.; Sumi, S.; Hosoda, S.; Zhao, S.; Fukunaga, T.; Hamada, M.

10.1101/2021.02.26.433129 — bioinformatics — Posted on 2021-02-27

104 Whole Genome and Exome Sequencing Reference Datasets from A Multi-center and Cross-platform Benchmark Study

Zhao, Y.; Fang, L. T.; Shen, T.-W.; Choudhari, S.; Talsania, K.; Chen, J.; Shetty, J.; Kriga, Y.; Tran, B.; Zhu, B.; Chen, Z.; Chen, W.; Wang, C.; Jaeger, E.; Meerzaman, D.; Lu, C.; Idler, K.; Zheng, Y.; Shi, L.; Petitjean, V.; Sultan, M.; Hung, T.; Peters, E.; Drabek, J.; Vojta, P.; Maestro, R.; Gasparotto, D.; Koks, S.; Reimann, E.; Scherer, A.; Nordlund, J.; Liljedahl, U.; Foox, J.; Mason, C.; Xiao, W.

10.1101/2021.02.27.433136 — bioinformatics — Posted on 2021-02-27

105 Bioptim, a Python framework for Musculoskeletal Optimal Control in Biomechanics

Michaud, B.; Bailly, F.; Charbonneau, E.; Ceglia, A.; Sanchez, L.; Begon, M.

10.1101/2021.02.27.432868 — bioengineering — Posted on 2021-02-27

106 Considerations on activity determinants of fungal polyphenol oxidases based on mutational and structural studies

Nikolaivits, E.; Valmas, A.; Dedes, G.; Topakas, E.; Dimarogona, M.

10.1101/2021.02.26.433144 — biochemistry — Posted on 2021-02-27

107 Structural basis of substrate recognition and translocation by human ABCA4

Xie, T.; Zhang, Z.; Du, B.; Fang, Q.; Gong, X.

10.1101/2021.02.27.433154 — biochemistry — Posted on 2021-02-27

108 Identification of theTMEM232 gene associated with atopic dermatitis through targeted capture sequencing

Zheng, J.; Wu, Y.-Y.; Fang, W.-L.; Cai, X.-Y.; Zhang, Z.-y.-o.; Yu, C.-X.; Zheng, X.; Xiao, F.-L.

10.1101/2021.02.25.432973 — genomics — Posted on 2021-02-27

109 Bioorthogonal labeling of transmembrane proteins with non-canonical amino acids allows access to masked epitopes in live neurons

Choquet, D.; Sauer, M.; Bessa-Neto, D.; Kuhlemann, A.; Beliu, G.; Pecoraro, V.; Retailleau, N.; Chevrier, N.; Perrais, D.; Doose, S.

10.1101/2021.02.27.433189 — cell biology — Posted on 2021-02-27

110 The Orb6-Sts5 Axis Regulates Stress Granule Formation and Heat Stress Response in Fission Yeast

Tams, R. N.; Chen, C.; Nunez, I.; Haller, P.; Verde, F.

10.1101/2021.02.26.432566 — cell biology — Posted on 2021-02-27

111 Ear wound healing in MRL/MpJ mice is associated with gut microbiome composition and is transferable to non-healer mice via microbiome transplantation

Velasco, C.; Dunn, C.; Sturdy, C.; Izda, V. A.; Martin, J. A.; Rivas, A.; McNaughton, J.; Jeffries, M. A.

10.1101/2021.02.25.432835 — molecular biology — Posted on 2021-02-27

112 Functional cooperativity mediated by rationally selected combinations of human monoclonal antibodies targeting the henipavirus receptor binding protein

Doyle, M. P.; Kose, N.; Borisevich, V.; Binshtein, E.; Amaya, M.; Nagel, M.; Annand, E. J.; Armstrong, E.; Bombardi, R.; Dong, J.; Schey, K. L.; Broder, C. C.; Zeitlin, L.; Kuang, E.; Bornholdt, Z.; West, B.; Geisbert, T. W.; Cross, R. W.; Crowe, J. E.

10.1101/2021.02.17.431743 — immunology — Posted on 2021-02-27

113 Plague risk in the western United States over seven decades of environmental change

Carlson, C. J.; Bevins, S. N.; Schmid, B. V.

10.1101/2021.02.26.433096 — ecology — Posted on 2021-02-27

114 Single-cell ATAC and RNA sequencing reveal pre-existing and persistent subpopulations of cells associated with relapse of prostate cancer

Taavitsainen, S.; Engedal, N.; Cao, S.; Handle, F.; Erickson, A.; Prekovic, S.; Wetterskog, D.; Tolonen, T.; Vuorinen, E. M.; Kiviaho, A.; Nätkin, R.; Häkkinen, T.; Devlies, W.; Henttinen, S.; Kaarijärvi, R.; Lahnalampi, M.; Kaljunen, H.; Nowakowska, K.; Syvälä, H.; Bläuer, M.; Cremaschi, P.; Claessens, F.; Visakorpi, T.; Tammela, T. L.; Murtola, T.; Granberg, K. J.; Lamb, A. D.; Ketola, K.; Mills, I. G.; Attard, G.; Wang, W.; Nykter, M.; Urbanucci, A.

10.1101/2021.02.09.430114 — cancer biology — Posted on 2021-02-27

115 Network Inference with Granger Causality Ensembles on Single-Cell Transcriptomic Data

Deshpande, A.; Chu, L.-F.; Stewart, R.; Gitter, A.

10.1101/534834 — bioinformatics — Posted on 2021-02-27

116 Fast and sensitive taxonomic assignment to metagenomic contigs

Mirdita, M.; Steinegger, M.; Breitwieser, F.; Soeding, J.; Levy Karin, E.

10.1101/2020.11.27.401018 — bioinformatics — Posted on 2021-02-27

117 Image denoising for fluorescence microscopy by self-supervised transfer learning

Wang, Y.; Pinkard, H.; Khwaja, E.; Zhou, S.; Waller, L.; Huang, B.

10.1101/2021.02.01.429188 — bioinformatics — Posted on 2021-02-27

118 Simulating rhizodeposition patterns around growing and exuding root systems

Landl, M.; Haupenthal, A.; Leitner, D.; Kroener, E.; Vetterlein, D.; Bol, R.; Vereecken, H.; Vanderborght, J.; Schnepf, A.

10.1101/2021.02.25.432851 — plant biology — Posted on 2021-02-27

119 Antiretroviral Theranostics Based on Intrinsic CEST Contrasts

Bade, A. N.; Gendelman, H.; McMillan, J. M.; Liu, Y.

10.1101/2021.02.25.432765 — bioengineering — Posted on 2021-02-27

120 High-Throughput Sequencing of 5S-IGS rDNA in Fagus L. (Fagaceae) reveals complex evolutionary patterns and hybrid origin of modern species

Cardoni, S.; Piredda, R.; Denk, T.; Grimm, G. W.; Papageorgiou, A. C.; Schulze, E.-D.; Scoppola, A.; Shanjani, P. S.; Suyama, Y.; Tomaru, N.; Worth, J. R. P.; Simeone, M. C.

10.1101/2021.02.26.433057 — evolutionary biology — Posted on 2021-02-27

121 Comprehensive analysis of chemical and biological problems associated with browning agents used in aquatic studies

Scharnweber, K.; Peura, S.; Attermeyer, K.; Bertilsson, S.; Bolender, L.; Buck, M.; Einarsdottir, K.; Garcia, S. L.; Gollnisch, R.; Grasset, C.; Groeneveld, M.; Hawkes, J.; Lindstrom, E. S.; Manthey, C.; Overgaard, R.; Rengefors, K.; Nunez, V. S.; Tranvik, L. J.; Szekely, A. J.

10.1101/2021.02.26.433092 — ecology — Posted on 2021-02-27

122 Aging impairs the essential contributions of non-glial progenitors to neurorepair in the dorsal telencephalon of the Killifish N. furzeri

Van houcke, J.; Marien, V.; Zandecki, C.; Vanhunsel, S.; Moons, L.; Ayana, R.; Seuntjens, E.; Arckens, L.

10.1101/2021.02.26.433041 — neuroscience — Posted on 2021-02-27

123 Improved correspondence of fMRI visual field localizer data after macroanatomical alignment

Qubad, M.; Barnes-Scheufler, C. V.; Schaum, M.; Raspor, E.; Roesler, L.; Peters, B.; Goebel, R.; Reif, A.; Bittner, R. A.

10.1101/2021.02.26.433066 — neuroscience — Posted on 2021-02-27

124 Multidimensional molecular differences between artificial and wild Artemisia rupestris L.

Zhou, Z.; Bin, X.; He, B.; Zhang, C.; Chen, L.; Wang, Z.; Chen, Y.; Abliz, Z.

10.1101/2021.02.26.433081 — systems biology — Posted on 2021-02-27

125 Gene regulatory networks for compatible versus incompatible grafts identify a role for SlWOX4 during junction formation

Thomas, H.; Van den Broeck, L.; Spurney, R.; Sozzani, R.; Frank, M.

10.1101/2021.02.26.433082 — plant biology — Posted on 2021-02-27

126 Sequence-unrelated long noncoding RNAs converged to modulate the activity of conserved epigenetic machineries across kingdoms

Fonouni-Farde, C.; Christ, A.; Blein, T.; Ramirez-Prado, J. S.; Legascue, M. F.; Latrasse, D.; Moison, M.; Lucero, L.; Ferrero, L.; Gonzalez, D.; Benhamed, M.; Quadrana, L.; Crespi, M.; Ariel, F.

10.1101/2021.02.26.433017 — plant biology — Posted on 2021-02-27

127 Discovering differential genome sequence activity with interpretable and efficient deep learning

Hammelman, J.; Gifford, D. K.

10.1101/2021.02.26.433073 — bioinformatics — Posted on 2021-02-27

128 GUIdeStaR (G-quadruplex, Uorf, IRES, Small RNA, Repeats), bioinformatics tool for gene characterization- case study: development of attribute selection and classification methods based on GuideStar for studying human transcription factor genes mediated by SARS-COV-2 small ncRNA

Kang, J. E.

10.1101/2021.02.25.432957 — bioinformatics — Posted on 2021-02-27

129 Podophyllotoxin And Quercetin In Silico Derivatives Docking Analysis With Cyclooxygenase-2 And Aminopeptidase-N

Manukyan, A.

10.1101/2021.02.26.433103 — bioinformatics — Posted on 2021-02-27

130 VCFCons: a versatile VCF-based consensus sequence generator for small genomes

Tseng, E.; Zeng, Q.; Iyer, L.

10.1101/2021.02.26.433111 — bioinformatics — Posted on 2021-02-27

131 DENTIST - using long reads to close assembly gaps at high accuracy

Ludwig, A.; Pippel, M.; Myers, G.; Hiller, M.

10.1101/2021.02.26.432990 — bioinformatics — Posted on 2021-02-27

132 Computational analysis of vertebrate myoglobins reveals aggregation resistance in aquatic birds and higher surface hydrophobicity in fish

Rizvi, S. M.; Zheng, W.; Zhang, C.; Zhang, Y.

10.1101/2021.02.26.433090 — bioinformatics — Posted on 2021-02-27

133 Chasing the cardiomyopathy modifier genes: Integrative computational analysis interweave the missing links in cardiomyopathy diseasome

Chauhan, P. K.; Sowdhamini, R.

10.1101/2021.02.26.433014 — bioinformatics — Posted on 2021-02-27

134 On bridging paired-end RNA-seq data

Li, X.; Shi, Q.; Shao, M.

10.1101/2021.02.26.433113 — bioinformatics — Posted on 2021-02-27

135 Machine learning for cell classification and neighborhood analysis in glioma tissue

Solorzano, L.; Wik, L.; Olsson Bontell, T.; Wang, Y.; Klemm, A. H.; Öfverstedt, J.; Jakola, A. S.; Östman, A.; Wählby, C.

10.1101/2021.02.26.433051 — bioinformatics — Posted on 2021-02-27

136 Segmentation of the Urothelium in Optical Coherence Tomography Images with Dynamic Contrast

Wang, H.; Xu, Z.; Zhu, H.

10.1101/2021.02.26.433072 — bioengineering — Posted on 2021-02-27

137 Discover Your Potential: The Influence of Kinematics on a Muscle's Ability to Contribute to the Sit-to-Stand Transfer

Roelker, S. A.; Schmitt, L. C.; Chaudhari, A. M. W.; Siston, R. A.

10.1101/2021.02.26.433097 — bioengineering — Posted on 2021-02-27

138 Marked differences in local bone remodeling in response to different marrow stimulation techniques in a large animal

Zlotnick, H. M.; Locke, R. C.; Stoeckl, B. D.; Patel, J. M.; Gupta, S.; Browne, K. D.; Koh, J.; Carey, J. L.; Mauck, R.

10.1101/2021.02.26.433037 — bioengineering — Posted on 2021-02-27

139 Insulin-like peptide receptor mediated signaling pathways orchestrate regulation of energy homeostasis in the Pacific oyster, Crassostrea gigas

Li, Y.; Fu, H.; Zhang, F.; Ren, L.; Tian, J.; Li, Q.; Liu, S.

10.1101/2021.02.25.432956 — genomics — Posted on 2021-02-27

140 Distribution of methionine sulfoxide reductases in fungi and conservation of the free-methionine-R-sulfoxide reductase in multicellular eukaryotes

Hage, H.; Rosso, M.-N.; Tarrago, L.

10.1101/2021.02.26.433065 — genomics — Posted on 2021-02-27

141 Genomic analyses of the extinct Sardinian dhole (Cynotherium sardous) reaveal its evolutionary history

Ciucani, M. M.; Sinding, M.-H. S.; Jensen, J. K.; Smith, O.; Bartolini Lucentini, S.; Rosengren, E.; Rook, L.; Tuveri, C.; Arca, M.; Cappellini, E.; Galaverni, M.; Randi, E.; Guojie, C.; Zhang, G.; Sicheritz-Ponten, T.; Dalen, L.; Gilbert, M. T. P.; Gopalakrishnan, S.

10.1101/2021.02.26.432714 — genomics — Posted on 2021-02-27

142 Multiple Loci Selection with Multi-way Epistasis in Coalescence with Recombination

Bose, A.; Utro, F.; Platt, D. E.; Parida, L.

10.1101/2021.02.26.433089 — genomics — Posted on 2021-02-27

143 Drivers of adaptive capacity in wild populations: implications for genetic interventions

Torda, G.; Quigley, K.

10.1101/2021.02.25.432972 — evolutionary biology — Posted on 2021-02-27

144 Phylogenomic Analyses Of 2,786 Genes In 158 Lineages Support a Root of The Eukaryotic Tree of Life Between Opisthokonts (Animals, Fungi and Their Microbial Relatives) and All Other Lineages

Ceron Romero, M. A.; Fonseca, M. M.; Martins, L. d. O.; Posada, D.; Katz, L. A.

10.1101/2021.02.26.433005 — evolutionary biology — Posted on 2021-02-27

145 Ionotropic receptors in the turnip moth Agrotis segetum respond to repellent medium-chain fatty acids

Hou, X.-Q.; Zhang, D.-D.; Powell, D.; Wang, H.-L.; Andersson, M. N.; Lofstedt, C.

10.1101/2021.02.25.432965 — evolutionary biology — Posted on 2021-02-27

146 Molecular response of whitefly to the wild tomato Solanum habrochaites

li, f.; Dewer, Y.; tian, j.; li, d.; qu, c.; luo, c.

10.1101/2021.02.26.432993 — ecology — Posted on 2021-02-27

147 Seasonal dynamics are the major driver of microbial diversity and composition in intensive freshwater aquaculture

Marmen, S.; Fadeev, E.; Al Ashhab, A.; Benet-Perelberg, A.; Naor, A.; Patil, H. J.; Cytryn, E.; Viner-Mozzini, D.; Sukenik, A.; Lalzar, M.; Sher, D.

10.1101/2021.02.26.433039 — ecology — Posted on 2021-02-27

148 Insights into biotic and abiotic modulation of ocean mesopelagic communities

rigonato, j.; Budinich, M.; Murillo, A. A.; Brandao, M. C.; Pierella Karlusich, J. J.; Soviadan, Y. D.; Gregory, A. C.; Endo, H.; Kokoszka, F.; Vik, D.; Henry, N.; Fremont, P.; Labadie, K.; Zayed, A. A.; Dimier, C.; Picheral, M.; Searson, S.; Poulain, J.; Kandels, S.; PESANT, S.; Karsenti, E.; Bork, P.; Bowler, C.; Chaffron, S.; de Vargas, C.; Eveillard, D.; Gehlen, M.; Iudicone, D.; Lombard, F.; Ogata, H.; Stemmann, L.; Sullivan, M. B.; Sunagawa, S.; Wincker, P.; Jaillon, O.

10.1101/2021.02.26.433055 — ecology — Posted on 2021-02-27

149 Plague risk in the western United States over seven decades of environmental change

Carlson, C. J.; Bevins, S. N.; Schmid, B. V.

10.1101/2021.02.26.433096 — ecology — Posted on 2021-02-27

150 Use of botanical gardens as arks for conserving pollinators and plant-pollinator interactions: A case study from the US Northern Great Plains

Vilella-Arnizaut, I. B.; Fenster, C. B.

10.1101/2021.02.26.433109 — ecology — Posted on 2021-02-27

151 The Epstein-Barr virus ubiquitin deconjugase BPLF1 regulates the activity of Topoisomerase II during virus replication

Li, J.; Nagy, N.; Liu, J.; Gupta, S.; Frisan, T.; Hennig, T.; Cameron, D. P.; Baranello, L.; Masucci, M. G.

10.1101/2021.02.26.433008 — microbiology — Posted on 2021-02-27

152 Chronic wireless neural population recordings with common marmosets

Walker, J.; Pirschel, F.; Sundiang, M.; Niekrasz, M.; MacLean, J. N.; Hatsopoulos, N.

10.1101/2021.02.25.432889 — neuroscience — Posted on 2021-02-27

153 Alpha Event-related Desynchronization During Reward Processing in Schizophrenia

Marton, T. F.; Roach, B.; Holroyd, C. B.; Ford, J. M.; McQuaid, J.; Mathalon, D. H.; Fryer, S. L.

10.1101/2021.02.25.432936 — neuroscience — Posted on 2021-02-27

154 Functional characterization of ovine dorsal root ganglion neurons reveals peripheral sensitization after osteochondral defect

Chakrabarti, S.; Ai, M.; Wong, W. Y. K.; Newell, K.; Henson, F.; Smith, E. S. J.

10.1101/2021.02.26.432434 — neuroscience — Posted on 2021-02-27

155 Perineuronal net receptor PTPσ regulates retention of memories

Lesnikova, A.; Casarotto, P. C.; Biojone, C.; Castren, E.

10.1101/2021.02.26.433000 — neuroscience — Posted on 2021-02-27

156 Effects of L-Dopa, SKF-38393, and Quinpirole on exploratory, anxiety- and depressive-like behaviors in pubertal female and male mice

Moraes, M. A.; Arabe, L. B.; Resende, B. L.; Codo, B. C.; Reis, A. L. A. L.; Souza, B. R.

10.1101/2021.02.26.433029 — neuroscience — Posted on 2021-02-27

157 Towards a two-stage model of action-stopping: Attentional capture explains motor inhibition during early stop-signal processing

Tatz, J.; Soh, C.; Wessel, J. R.

10.1101/2021.02.26.433098 — neuroscience — Posted on 2021-02-27

158 A Regression Framework for Brain Network Distance Metrics

Tomlinson, C. E.; Laurienti, P. J.; Lyday, R. G.; Simpson, S. L.

10.1101/2021.02.26.432910 — neuroscience — Posted on 2021-02-27

159 3D Neuronal Mitochondrial Morphology in Axons, Dendrites, and Somata of the Aging Mouse Hippocampus

Faitg, J.; Lacefield, C.; Davey, T.; White, K.; Laws, R.; Kosmidis, S.; Reeve, A. K.; Kandel, E.; Vincent, A. E.; Picard, M.

10.1101/2021.02.26.433056 — neuroscience — Posted on 2021-02-27

160 High and low expression of the hyperpolarization activated current (Ih) in mouse CA1 stratum oriens interneurons.

Hewitt, L. T.; Ordemann, G. J.; Brager, D. H.

10.1101/2021.02.26.433114 — neuroscience — Posted on 2021-02-27

161 NiftyTorch: A Deep Learning framework for NeuroImaging

Subramanian, A.; Lan, H.; Govindarajan, S.; Viswanathan, L.; Choupan, J.; Sepehrband, F.

10.1101/2021.02.26.433116 — neuroscience — Posted on 2021-02-27

162 A fungal powdery mildew pathogen induces extensive local and marginal systemic changes in the Arabidopsis thaliana microbiota

Duran, P.; Reinstaedler, A.; Rajakrut, A. L.; Hashimoto, M.; Garrido-Oter, R.; Schulze-Lefert, P.; Panstruga, R.

10.1101/2021.02.26.432829 — plant biology — Posted on 2021-02-27

163 Alternative electron pathways of photosynthesis drive the algal CO2 concentrating mechanism

Burlacot, A.; Dao, O.; Auroy, P.; Cuine, S.; Li-Beisson, Y.; Peltier, G.

10.1101/2021.02.25.432959 — plant biology — Posted on 2021-02-27

164 UV-B exposure and exogenous hydrogen peroxide application leads to cross-tolerance toward drought in Nicotiana tabacum L.

Saenz de la O, D.; Morales, L. O.; Strid, A.; Torres-Pacheco, I.; Guevara-Gonzalez;, R. G.

10.1101/2021.02.26.432958 — plant biology — Posted on 2021-02-27

165 TRPV1 in arteries enables a rapid myogenic tone

Phan, T. X.; Ton, H. T.; Gulyas, H.; Porszasz, R.; Toth, A.; Russo, R.; Kay, M. W.; Sahibzada, N.; Ahern, G. P.

10.1101/2021.02.25.432719 — physiology — Posted on 2021-02-27

166 AMBIENT: Accelerated Convolutional Neural Network Architecture Search for Regulatory Genomics

Zhang, Z.; Cofer, E. M.; Troyanskaya, O. G.

10.1101/2021.02.25.432960 — bioinformatics — Posted on 2021-02-27

167 IHRW: An Improved Hypergraph Random Walk Model for Predicting Three-Drug Therapy

Wang, Q.; Yan, G.

10.1101/2021.02.25.432979 — bioinformatics — Posted on 2021-02-27

168 LSTM-PHV: Prediction of human-virus protein-protein interactions by LSTM with word2vec

Tsukiyama, S.; Hasan, M. M.; Fujii, S.; Kurata, H.

10.1101/2021.02.26.432975 — bioinformatics — Posted on 2021-02-27

169 Multidimensional Single-Nuclei RNA-Seq Reconstruction of Adipose Tissue Reveals Adipocyte Plasticity Underlying Thermogenic Response

Biagi, C. A.; Cury, S. S.; Alves, C. P.; Rabhi, N.; Silva, W. A.; Farmer, S. R.; Carvalho, R. F.; Batista, M. L.

10.1101/2021.02.16.431320 — cell biology — Posted on 2021-02-27

170 Cell-to-cell heterogeneities during extrinsic apoptosis arise from cell cycle progression and transmitotic apoptosis resistance

Pollak, N.; Lindner, A.; Imig, D.; Kuritz, K.; Fritze, J. S.; Heinrich, I.; Stadager, J.; Eisler, S. A.; Stöhr, D.; Allgöwer, F.; Scheurich, P.; Morrison (Rehm), M.

10.1101/2021.02.26.433034 — cell biology — Posted on 2021-02-27

171 A Tad-like apparatus is required for contact-dependent prey killing in predatory social bacteria

Seef, S.; Herrou, J.; de Boissier, P.; My, L.; Brasseur, G.; Robert, D.; Jain, R.; Mercier, R.; Cascales, E.; Habermann, B. H.; Mignot, T.

10.1101/2021.02.25.432843 — microbiology — Posted on 2021-02-27

172 Comparative genomics analysis of Chryseobacterium sp. KMC2 reveals metabolic pathways involved in keratinous utilization and natural product biosynthesis

Kang, D.; Shoaie, S.; Jacquiod, S.; Sorensen, S. J.; Ledesma-Amaro, R.

10.1101/2021.02.23.432615 — microbiology — Posted on 2021-02-27

173 Analyses of the complete genome sequence of 2,6-dichlorobenzamide (BAM) degrader Aminobacter sp. MSH1 suggests a polyploid chromosome, phylogenetic reassignment, and functions of (un)stable plasmids.

Nielsen, T. K.; Horemans, B.; Lood, C.; T'Syen, J.; van Noort, V.; Lavigne, R.; Ellegaard-Jensen, L.; Hylling, O.; Aamand, J.; Springael, D.; Hansen, L. H.

10.1101/2021.02.25.432982 — microbiology — Posted on 2021-02-27

174 Gene flux and acid-imposed selection are the main drivers of antimicrobial resistance in broiler chicks infected with Salmonella enterica serovar Heidelberg

Oladeine, A.; Abdo, Z.; Press, M. O.; Cook, K.; Cox, N. A.; Zwirzitz, B.; Woyda, R.; Lakin, S. M.; Thomas, J. C.; Looft, T.; Cosby, D. E.; Hinton, A.; Guard, J.; Line, E.; Rothrock, M. J.; Berrang, M. E.; Herrington, K.; Zock, G.; Plumblee Lawrence, J.; Cudnik, D.; House, S.; Ingram, K.; Lariscy, L.; Wagner, M.; Aggrey, S. E.; Chai, L.; Ritz, C.

10.1101/2021.02.25.432983 — microbiology — Posted on 2021-02-27

175 A public broadly neutralizing antibody class targets a membrane-proximal anchor epitope of influenza virus hemagglutinin

Guthmiller, J. J.; Han, J.; Utset, H. A.; Li, L.; Lan, L. Y.-L.; Henry, C.; Stamper, C. T.; Stovicek, O.; Gentles, L.; Dugan, H. L.; Zheng, N.-Y.; Richey, S. T.; Tepora, M. E.; Bitar, D. J.; Changrob, S.; Strohmeier, S.; Huang, M.; Garcia-Sastre, A.; Nachbagauer, R.; Palese, P.; Bloom, J. D.; Krammer, F.; Coughlan, L.; Ward, A. B.; Wilson, P. C.

10.1101/2021.02.25.432905 — immunology — Posted on 2021-02-27

176 Uncovering Network Architecture Using an Exact Statistical Input-Output Relation of a Neuron Model

Rashid Shomali, S.; Rasuli, S. N.; Nili Ahmadabadi, M.; Shimazaki, H.

10.1101/479956 — neuroscience — Posted on 2021-02-27

177 Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption

Tang, C.-C.; Castro, C.; O'Meara, M. J.; Yoon, S.-H.; Brooks, D. J.; Bouxsein, M. L.; Martins, J. d. S.; Wang, J.; Gray, N. S.; Misof, B.; Roschger, P.; Boulin, S.; Klaushofer, K.; Velduis-Vlug, A.; Vegting, Y.; Rosen, C. J.; O'Connell, D.; Sundberg, T. B.; Xavier, R. J.; Ung, P.; Schlessinger, A.; Kronenberg, H. M.; Berdeaux, R.; Foretz, M.; Wein, M. N.

10.1101/2021.02.26.433094 — physiology — Posted on 2021-02-27

178 Characterising ontogeny of numerosity discrimination in zebrafish reveals multiple, numerical and non- numerical mechanisms.

Sheardown, E.; Torres-Perez, J. V.; Anagianni, S.; Fraser, S.; Vallortigara, G.; Butterworth, B.; Miletto-Petrazzini, M. E.; Brennan, C. H.

10.1101/2021.02.25.432846 — animal behavior and cognition — Posted on 2021-02-27

179 AIM-CICs: automatic identification method for Cell-in-cell structures based on convolutional neural network

Tang, M.; Su, Y.; Zhao, W.; Niu, Z.; Ruan, B.; Li, Q.; Zheng, Y.; Wang, C.; Zhou, Y.; Zhang, B.; Zhou, F.; Huang, H.; Shi, H.; Sun, Q.

10.1101/2021.02.26.432996 — cell biology — Posted on 2021-02-27

180 Fiber-associated Lachnospiraceae reduce colon tumorigenesis by modulation of the tumor-immune microenvironment

Almeida, A. S.; Tran, T. T. T.; Ghosh, T. S.; Ribiere, C.; Foley, C.; Alves, L. A.; Pellanda, P.; Frei, W.; Hueston, C. M.; Kumar, R.; Flemer, B.; Sequeira, I.; O'Riordain, M.; Shanahan, F.; O'Toole, P. W.

10.1101/2021.02.24.432654 — microbiology — Posted on 2021-02-27

181 Burst Control

Leleo, E. G.; Segev, I.

10.1101/2021.02.13.431061 — neuroscience — Posted on 2021-02-27

182 Extended numerical analysis of an eyeball injury under direct impact

Koberda, M.; Skorek, A.; Kłosowski, P.; Zmuda-Trzebiatowski, M.; Zerdzicki, K.; Lemski, P.; Stodolska-Koberda, U.

10.1101/2021.02.26.433021 — pathology — Posted on 2021-02-26

183 Identification of Hsp90 inhibitors as potential drugs for the treatment of TSC1/TSC2 deficient cancer

Mrozek, E. M.; Bajaj, V.; Guo, Y.; Malinowska, I.; Zhang, J.; Kwiatkowski, D. J.

10.1101/2021.02.26.433022 — cancer biology — Posted on 2021-02-26

184 THz irradiation inhibits cell division by affecting actin dynamics

yamazaki, s.; Ueno, Y.; Hosoki, R.; Saito, T.; Idehara, T.; Yamaguchi, Y.; Otani, C.; Ogawa, Y.; Harata, M.; Hoshina, H.

10.1101/2021.02.26.433024 — cell biology — Posted on 2021-02-26

185 A cytofluorimetric analysis of a Saccharomyces cerevisiae population cultured in a fed-batch bioreactor

Sanchez, M.; Palomba, E.; Tirelli, V.; de Alteriis, E.; Landi, C.; Mazzoleni, S.

10.1101/2021.02.26.433019 — cell biology — Posted on 2021-02-26

186 A novel reticular oscillator in the brainstem synchronizes neonatal crying with breathing

Wei, X. P.; Collie, M.; Dempsey, B.; Fortin, G.; Yackle, K.

10.1101/2021.02.26.433060 — neuroscience — Posted on 2021-02-26

187 Sparse balance: excitatory-inhibitory networks with small bias currents and broadly distributed synaptic weights

Khajeh, R.; Fumarola, F.; Abbott, L.

10.1101/2021.02.26.433027 — neuroscience — Posted on 2021-02-26

188 Choice of method of place cell classification determines the population of cells identified.

Grijseels, D. M.; Shaw, K.; Barry, C.; Hall, C. N.

10.1101/2021.02.26.433025 — neuroscience — Posted on 2021-02-26

189 Brief report: Attentional Bias towards Social Interactions during Viewing of Naturalistic Scenes

Skripkauskaite, S.; Mihai, I.; Koldewyn, K.

10.1101/2021.02.26.433078 — neuroscience — Posted on 2021-02-26

190 Increasing central serotonin with 5-HTP disrupts the inhibition of social gaze in non-human primates

Weinberg-Wolf, H.; Fagan, N. A.; Dal Monte, O.; Chang, S. W. C.

10.1101/2021.02.26.431901 — neuroscience — Posted on 2021-02-26

191 Biomechanical evaluation of a novel orthogonal angle-stable interlocking nail in a canine femur model

Lucena, D.; Farias, D. V. F.; Minto, B. W.; Rocha, T. A. S. S.; Malta, C. A. S.; Galindez, J. A. S.; Dias, L. G. G. G.

10.1101/2021.02.26.433020 — bioengineering — Posted on 2021-02-26

192 Multiple metabolic signals including AMPK and PKA regulate glucose-stimulated double strand break resection in yeast

Lomonaco, S.; Bazzano, D.; Wilson, T. E.

10.1101/2021.02.26.433101 — genetics — Posted on 2021-02-26

193 Parallel evolution of a splicing program controlling neuronal excitability in flies and mammals

Torres-Mendez, A.; Pop, S.; Bonnal, S.; Almudi, I.; Roberts, R. J. V.; Paolantoni, C.; Alcaina, A.; Avola, A.; Martin Anduaga, A.; Haussmann, I. H.; Morin, V.; Casares, F.; Soller, M.; Kadener, S.; Roignant, J.-Y.; Prieto-Godino, L.; Irimia, M.

10.1101/2021.02.24.432780 — molecular biology — Posted on 2021-02-26

194 Immunity-longevity tradeoff neurally controlled by GABAergic transcription factor PITX1/UNC-30

Otarigho, B.; Aballay, A.

10.1101/2021.02.25.432801 — immunology — Posted on 2021-02-26

195 An integrated comparative physiology and molecular approach pinpoints mediators of breath-hold capacity in dolphins

Blawas, A. M.; Ware, K. E.; Schmaltz, E.; Zheng, L.; Spruance, J.; Allen, A. S.; West, N.; Devos, N.; Corcoran, D. L.; Nowacek, D. P.; Eward, W. C.; Fahlman, A.; Somarelli, J. A.

10.1101/2021.01.20.425775 — physiology — Posted on 2021-02-26

196 Ovarian Tumor Mitochondria Exhibit Abnormal Phenotypes and Blunted Associations with Biobehavioral Factors

Bindra, S.; McGill, M. A.; Triplett, M. K.; Tyagi, A.; Thaker, P. H.; Dahmoush, L.; Goodheart, M. J.; Ogden, T.; Owusu-Ansah, E.; Karan, K.; Cole, S.; Sood, A. K.; Lutgendorf, S. K.; Picard, M.

10.1101/2021.02.26.432917 — cancer biology — Posted on 2021-02-26

197 FINDER: An automated software package to annotate eukaryotic genes from RNA-Seq data and associated protein sequences

Banerjee, S.; Bhandary, P.; Woodhouse, M. R.; Sen, T. Z.; Wise, R. P.; Andorf, C. M.

10.1101/2021.02.04.429837 — bioinformatics — Posted on 2021-02-26

198 The Diameter Factor of Aligned Electrospinning Membranes Facilitates Cutaneous Wound Healing by Promoting Epithelialization

Wang, C.; Chu, C.; Zhao, X.; Hu, C.; Liu, L.; Li, J.; Qu, Y.; Man, Y.

10.1101/2021.02.25.432929 — bioengineering — Posted on 2021-02-26

199 High-throughput functional analysis of natural variants in yeast

Yeh, C.-L. C.; Tsouris, A.; Schacherer, J.; Dunham, M. J.

10.1101/2021.02.26.433108 — genetics — Posted on 2021-02-26

200 X chromosome-dependent disruption of placental regulatory networks in hybrid dwarf hamsters

Brekke, T. D.; Moore, E. C.; Campbell-Staton, S. C.; Callahan, C. M.; Cheviron, Z. A.; Good, J. M.

10.1101/2020.09.15.298893 — evolutionary biology — Posted on 2021-02-26

201 Scientific modelling can be accessible, interoperable and user friendly: An example for pasture and livestock modelling

Marquez Torres, A.; Balbi, S.; Villa, F.

10.1101/2021.02.23.432363 — ecology — Posted on 2021-02-26

202 PI3K Signaling Specifies Proximal-Distal Fate by Driving a Developmental Gene Regulatory Network in Sox9+ Lung Progenitors

Khattar, D.; Fernandes, S.; Snowball, J.; Guo, M.; Gillen, M. C.; Sinner, D. I.; Zacharias, W.; Swarr, D. T.

10.1101/2021.02.26.433053 — developmental biology — Posted on 2021-02-26

203 Asymmetric Contraction of Adherens Junctions arises through RhoA and E-cadherin feedback

Cavanaugh, K.; Staddon, M.; Chmiel, T. A.; Harmon, R. M.; Budnar, S.; Yap, A. S.; Banerjee, S.; Gardel, M.

10.1101/2021.02.26.433093 — cell biology — Posted on 2021-02-26

204 The Aurora B gradient sustains kinetochore stability in anaphase

Papini, D.; Levasseur, M.; Higgins, J. M. G.

10.1101/2021.02.26.433106 — cell biology — Posted on 2021-02-26

205 Completion of the gut microbial epi-bile acid pathway

Doden, H. L.; Alves, J. M. P.; Ridlon, J. M.; Wolf, P. G.; Gaskins, H. R.; Anantharaman, K.

10.1101/2020.09.27.315549 — microbiology — Posted on 2021-02-26

206 Incomplete recruitment of protective T cells facilitates Trypanosoma cruzi persistence in the mouse colon

Ward, A. I.; Lewis, M. D.; Taylor, M. C.; Kelly, J. M.

10.1101/2021.02.26.433032 — immunology — Posted on 2021-02-26

207 Microglia become hypofunctional and release metalloproteases and tau seeds after phagocytosing live neurons with P301S tau aggregates

Spillantini, M. G.; Brelstaff, J. H.; Mason, M.; Katsinelos, T.; McEwan, W. A.; Ghetti, B.; Tolkovsky, A. M.

10.1101/2021.02.26.433088 — neuroscience — Posted on 2021-02-26

208 Oxytocin administration in neonates shapes the hippocampal circuitry and restores social behavior in a mouse model of autism.

Bertoni, A.; Schaller, F.; Tyzio, R.; Gaillard, S.; Santini, F.; Xolin, M.; Diabira, D.; Vaidyanathan, R.; Matarazzo, V.; Medina, I.; Hammock, E.; Zhang, J.; Chini, B.; Gaiarsa, J.-L.; Muscatelli, F.

10.1101/2020.09.21.306217 — neuroscience — Posted on 2021-02-26

209 Calbindin regulates Kv4.1 trafficking and excitability of dentate granule cells via CaMKII-dependent phosphorylation

Kim, K.-R.; Jeong, H.-J.; Kim, Y.; Lee, S. Y.; Kim, Y.; Kim, H.-J.; Lee, S.-H.; Cho, H.; Kim, J.-S.; Ho, W.-K.

10.1101/2021.02.26.433035 — neuroscience — Posted on 2021-02-26

210 Acyloxyacyl Hydrolase Regulates Microglia-Mediated Pelvic Pain Through Toll-Like Receptor-4

Rahman-Enyart, A.; Yaggie, R. E.; Yang, W.; Bollinger, J. L.; Winter, D. R.; Schaeffer, A. J.; Klumpp, D. J.

10.1101/2021.02.26.433087 — neuroscience — Posted on 2021-02-26

211 Multi-modal artificial dura for simultaneous large-scale optical access and large-scaleelectrophysiology in non-human primate cortex

Griggs, D. J.; Khateeb, K.; Zhou, J.; Liu, T.; Wang, R. K.; Yazdan-Shahmorad, A.

10.1101/2021.02.03.429596 — neuroscience — Posted on 2021-02-26

212 Synergistic neural integration is greater downstream of recurrent information flow in organotypic cortical cultures

Sherrill, S. P.; Timme, N. M.; Beggs, J. M.; Newman, E. L.

10.1101/2020.05.12.091215 — neuroscience — Posted on 2021-02-26

213 Cyclocreatine suppresses prostate tumorigenesis through dual effects on SAM and creatine metabolism

Patel, R.; Rodgers, L.; Ford, C. A.; Rushworth, L.; Fleming, J.; Mui, E.; Zhang, T.; Watson, D. G.; MacKay, G.; Sumpton, D.; Sansom, O. J.; Leung, H. Y.

10.1101/2021.02.26.432994 — cancer biology — Posted on 2021-02-26

214 Resolving the spatial and cellular architecture of lung adenocarcinoma by multi-region single-cell sequencing

Sinjab, A.; Han, G.; Treekitkarnmongkol, W.; Kobayashi, K.; Brennan, P.; Dang, M.; Hao, D.; Wang, R.; Dai, E.; Dejima, H.; Zhang, J.; Bogatenkova, E.; Sanchez-Espiridion, B.; Chang, K.; Little, D. R.; Bazzi, S.; Tran, L.; Krysan, K.; Behrens, C.; Duose, D.; Parra, E. R.; Raso, M. G.; Solis, L. M.; Fukuoka, J.; Zhang, J.; Sepesi, B.; Cascone, T.; Byers, L.; Gibbons, D. L.; Chen, J.; Moghaddam, S. J.; Ostrin, E. J.; Rosen, D. G.; Heymach, J. V.; Scheet, P.; Dubinett, S.; Fujimoto, J.; Wistuba, I. I.; Stevenson, C. S.; Spira, A. E.; Wang, L.; Kadara, H.

10.1101/2020.09.04.283739 — cancer biology — Posted on 2021-02-26

215 An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma

Zewdu, R.; Mehrabad, E. M.; Ingram, K.; Fang, P.; Gillis, K. L.; Camolotto, S. A.; Orstad, G.; Jones, A.; Mendoza, M. C.; Spike, B. T.; Snyder, E. L.

10.1101/2020.02.25.965004 — cancer biology — Posted on 2021-02-26

216 NMR Hydrogen Exchange and Relaxation Reveal Positions Stabilized by p53 Rescue Mutants N239Y and N235K

Soto, J.; Moody, C.; Alhoshani, A.; Sanchez-Bonilla, M.; Martinon, D.; Cocco, M. J.

10.1101/2021.02.26.433080 — biophysics — Posted on 2021-02-26

217 Guest-host supramolecular assembly of injectable hydrogel fibers for cell encapsulation

Miller, B.; Hansrisuk, A.; Highley, C. B.; Caliari, S. R.

10.1101/2021.02.26.430926 — bioengineering — Posted on 2021-02-26

218 Bi-phasic dynamics of the mitochondrial DNA mutation m.3243A>G in blood: An unbiased, mutation level-dependent model implies positive selection in the germline.

Fleishmann, Z.; Pickett, S. J.; Franco, M.; Aidlen, D.; Khrapko, M.; Stein, D.; Markuzon, N.; Popadin, K.; Braverman, M.; Woods, D. C.; Tilly, J. L.; Turnbull, D.; Khrapko, K.

10.1101/2021.02.26.433045 — genomics — Posted on 2021-02-26

219 Global genetic heterogeneity in adaptive traits

Lopez-Arboleda, W. A.; Reinert, S.; Nordborg, M.; Korte, A.

10.1101/2021.02.26.433043 — evolutionary biology — Posted on 2021-02-26

220 Tracking cell lineages in 3D by incremental deep learning

Sugawara, K.; Cevrim, C.; Averof, M.

10.1101/2021.02.26.432552 — developmental biology — Posted on 2021-02-26

221 Electrostatic Plasma Membrane Targeting Contributes to Dlg Function in Cell Polarity and Tumorigenesis

Lu, J.; Dong, W.; Tao, Y.; Hong, Y.

10.1101/2020.10.08.331603 — developmental biology — Posted on 2021-02-26

222 Identification of Human CD4+ Sub-population of Resident Cardiac Fibroblasts Linked to Inflammation-Mediated Cardiac Fibrosis

Siamwala, J. H.; Pagano, F.; Dubielecka, P. M.; Zhao, A.; Chen, S.; Granston, H.; Rounds, S.; Gilbert, R. J.

10.1101/2021.02.26.433023 — cell biology — Posted on 2021-02-26

223 Microtubule-based Transport is Essential to Distribute RNA and Nascent Protein in Skeletal Muscle

Denes, L. T.; Kelley, C. P.; Wang, E. T.

10.1101/2021.02.26.433059 — cell biology — Posted on 2021-02-26

224 Big fish, little fish: N-terminal acetyltransferase Naa40p proteoforms caught in the act

Jonckheere, V.; Van Damme, P.

10.1101/2021.02.26.433048 — molecular biology — Posted on 2021-02-26

225 Bortezomib inhibits lung fibrosis and fibroblast activation without proteasome inhibition

Penke, L. R. K.; Speth, J.; Wettlaufer, S.; Draijer, C.; Peters-Golden, M.

10.1101/2021.02.26.433086 — molecular biology — Posted on 2021-02-26

226 Transcriptional regulation of HSFA7 and post-transcriptional modulation of HSFB4a by miRNA4200 govern general and varietal thermotolerance in tomato

Rao, S.; Balyan, S.; Das, J. R.; Verma, R.; Mathur, S.

10.1101/2021.02.26.433069 — molecular biology — Posted on 2021-02-26

227 Calprotectin-mediated zinc chelation inhibits Pseudomonas aeruginosa protease activity in cystic fibrosis sputum

Vermilyea, D. M.; Crocker, A. W.; Gifford, A. H.; Hogan, D. A.

10.1101/2021.02.25.432981 — microbiology — Posted on 2021-02-26

228 Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulence

De Niz, M.; Bras, D.; Pedro, M.; Nascimento, A. M.; Franco, C. A.; Figueiredo, L. M.

10.1101/2021.02.26.433042 — microbiology — Posted on 2021-02-26

229 Growth response and recovery of Corynebacterium glutamicum colonies on single-cell level upon defined pH stress pulses

Täuber, S.; Blöbaum, L.; Wendisch, V. F.; Grünberger, A.

10.1101/2021.02.26.433016 — microbiology — Posted on 2021-02-26

230 DENGUE VIRUS ALTERS SIALIC ACID RESIDUES CONFIGURATION IN MACROPHAGES

Serrato-Salas, J.; Cruz Zazueta, I.; Montiel Hernandez, J. L.; Gonzalez Christen, J.

10.1101/2021.02.26.433067 — immunology — Posted on 2021-02-26

231 IL-10 driven memory T cell survival and Tfh differentiation promote HIV persistence

Pereira Ribeiro, S.; Aid, M.; Dupuy, F. P.; Ngai Chan, C.; Hultquist, J.; Deleage, C.; Moysi, E.; Kulpa, D. A.; Li, L.; Xu, X.; Tamilselvan, B.; Tomalka, J. A.; Nekorchuk, M.; Busman-Sahay, K.; Bordi, R.; Simoneau, C.; Goulet, J. P.; Marconi, V.; Routy, J. P.; Balderas, R.; Micci, L.; J Howell, B.; H Barouch, D.; Krogan, N. J.; Petrovas, C.; Paiardini, M.; Deeks, S.; Estes, J. D.; Gorman, D.; J Hazuda, D.; Sekaly, R.-P.

10.1101/2021.02.26.432955 — immunology — Posted on 2021-02-26

232 Xenogeneic Skin Transplantation Promotes Angiogenesis and Tissue Regeneration Through Vitamin D-Activated Trem2+ Macrophages

Henn, D.; Chen, K.; Fehlmann, T.; Sivaraj, D.; Maan, Z.; Bonham, C. A.; Barrera, J. A.; Mays, C. J.; Greco, A. H.; Moortgat Illouz, S. E.; Lin, J. Q.; Foster, D.; Padmanabhan, J.; Momeni, A.; Nguyen, D.; Wan, D. C.; Kneser, U.; Januszyk, M.; Keller, A.; Longaker, M. T.; Gurtner, G. C.

10.1101/2021.02.26.432991 — immunology — Posted on 2021-02-26

233 Modeling of DNA binding to the condensin hinge domain using molecular dynamics simulations guided by atomic force microscopy

Koide, H.; Kodera, N.; Bisht, S.; Takada, S.; Terakawa, T.

10.1101/2021.02.25.432963 — biophysics — Posted on 2021-02-26

234 Allostery in Proteins as Point-to-Point Telecommunication in a Network: Frequency Decomposed Signal-to-Noise Ratio and Channel Capacity Analysis

Bozkurt Varolgunes, Y.; Rudzinski, J. F.; Demir, A.

10.1101/2021.02.26.433010 — biophysics — Posted on 2021-02-26

235 Stability of ligand-induced protein conformation influences affinity in maltose-binding protein

van der Noort, M.; de Boer, M.; Poolman, B.

10.1101/2021.02.26.433038 — biochemistry — Posted on 2021-02-26

236 Generation of excitatory and inhibitory neurons from common progenitors via Notch signaling in the cerebellum

Zhang, T.; Liu, T.; Mora, N.; Guegan, J.; Bertrand, M.; Contreras, X.; Hansen, A.; Streicher, C.; Anderle, M.; Tiberi, L.; Hippenmeyer, S.; Hassan, B. A.

10.1101/2020.03.18.997205 — developmental biology — Posted on 2021-02-26

237 An anaphase surveillance mechanism prevents micronuclei formation from mitotic errors

Orr, B.; De Sousa, F.; Gomes, M.; Ferreira, L. T.; Figueiredo, A. C.; Maiato, H.

10.1101/2021.02.26.433009 — cell biology — Posted on 2021-02-26

238 Comparative infectivity and pathogenesis of emerging SARS-CoV-2 variants in Syrian hamsters

Abdelnabi, R.; Boudewijns, R.; Foo, C. S.-Y.; Seldeslachts, L.; Sanchez-Felipe, L.; Zhang, X.; Delang, L.; Maes, P.; Kaptein, S. J. F.; Weynand, B.; Vande Velde, G.; Neyts, J.; Dallmeier, K.

10.1101/2021.02.26.433062 — microbiology — Posted on 2021-02-26

239 Graphene oxide/silver nanoparticle ink formulations rapidly inhibit influenza A virus and OC43 coronavirus infection in vitro

Crane, M. J.; Devine, S.; Jamieson, A. M.

10.1101/2021.02.25.432893 — microbiology — Posted on 2021-02-26

240 Antibodies with potent and broad neutralizing activity against antigenically diverse and highly transmissible SARS-CoV-2 variants

Wang, L.; Zhou, T.; Zhang, Y.; Yang, E. S.; Schramm, C. A.; Shi, W.; Pegu, A.; Oloninyi, O. K.; Ransier, A.; Darko, S.; Narpala, S. R.; Hatcher, C.; Martinez, D. R.; Tsybovsky, Y.; Phung, E.; Abiona, O. M.; Cale, E. M.; Change, L. A.; Corbett, K. S.; DiPiazza, A. T.; Gordon, I. J.; Leung, K.; Liu, T.; Mason, R. D.; Nazzari, A.; Novik, L.; Olia, A. S.; Stephens, T.; Stringham, C. D.; Talana, C. A.; Teng, I.-T.; Wagner, D.; Widge, A. T.; Zhang, B.; Roederer, M.; Ledgerwood, J. E.; Ruckwardt, T. J.; Gaudinski, M. R.; Baric, R. S.; Graham, B. S.; McDermott, A. B.; Doueck, D. C.; Kwong, P. D.; Masc

10.1101/2021.02.25.432969 — immunology — Posted on 2021-02-26

241 Dynamic arrest and aging of biomolecular condensates are regulated by low-complexity domains, RNA and biochemical activity

Linsenmeier, M.; Hondele, M.; Grigolato, F.; Secchi, E.; Weis, K.; Arosio, P.

10.1101/2021.02.26.433003 — biophysics — Posted on 2021-02-26

242 Activity-induced fluidization of arrested coalescence in fusion of cellular aggregates

Ongenae, S.; Cuvelier, M.; Vangheel, J.; Ramon, H.; Smeets, B.

10.1101/2021.02.26.433001 — biophysics — Posted on 2021-02-26

243 Negative DNA supercoiling tunes protein-mediated looping

Yan, Y.; Xu, W.; Kumar, S.; Zhang, A.; Leng, F.; Dunlap, D.; Finzi, L.

10.1101/2021.02.25.432970 — biophysics — Posted on 2021-02-26

244 Decisive Role of Polymer-BSA Interactions in Biofilm Substrates on Philicity and EPS Composition

DuttaSinha, S.; Choudhuri, M.; Basu, T.; Gupta, D.; Datta, A.

10.1101/2021.02.26.433004 — biophysics — Posted on 2021-02-26

245 Description and analysis of glycosidic residues in the largest open natural products database

Schaub, J.; Zielesny, A.; Steinbeck, C.; Sorokina, M.

10.1101/2021.02.25.432909 — bioinformatics — Posted on 2021-02-26

246 Targeted replacement of full-length CFTR in human airway stem cells by CRISPR/Cas9 for pan-mutation correction in the endogenous locus

Vaidyanathan, S.; Baik, R.; Chen, L.; Bravo, D. T.; Suarez, C. J.; Abazari, S. M.; Salahudeen, A. A.; Dudek, A. M.; Teran, C. A.; Davis, T. H.; Lee, C. M.; Bao, G.; Randell, S. H.; Artandi, S. E.; Wine, J. J.; Kuo, C. J.; Desai, T. J.; Nayak, J. V.; Sellers, Z. M.; Porteus, M.

10.1101/2021.02.26.432961 — bioengineering — Posted on 2021-02-26

247 H3K36 methylation and DNA-binding are critical for Ioc4 recruitment and Isw1b remodeller function

Li, J.; Bergmann, L.; Webb, K. M.; Gogol, M. M.; Voigt, P.; Liu, Y.; Liang, H.; Smolle, M. M.

10.1101/2021.02.26.432832 — biochemistry — Posted on 2021-02-26

248 A new parallel high-pressure packing system enables rapid multiplexed production of capillary columns

Mueller-Reif, J. B.; Hansen, F. M.; Schweizer, L.; Treit, P. V.; Geyer, P. E.; Mann, M.

10.1101/2021.02.26.433033 — biochemistry — Posted on 2021-02-26

249 Physiological and transcriptomic variability indicative of differences in key functions within a single coral colony

Drake, J.; Malik, A.; Popovits, Y.; Yosef, O.; Shamesh, E.; Stolarski, J.; Tchernov, D.; Sher, D.; Mass, T.

10.1101/2021.02.25.432919 — genomics — Posted on 2021-02-26

250 The impact of invader number on whole community invasions in biomethane-producing communities

Sierocinski, P.; Soria Pascual, J.; Padfield, D.; Salter, M.; Buckling, A.

10.1101/2021.02.25.432953 — ecology — Posted on 2021-02-26

251 Quantitative mapping of dense microtubule arrays in mammalian neurons

Katrukha, E. A.; Jurriens, D.; Salas, D. M.; Kapitein, L.

10.1101/2021.02.26.432992 — cell biology — Posted on 2021-02-26

252 AIM-CICs: automatic identification method for Cell-in-cell structures based on convolutional neural network

Tang, M.; Su, Y.; Zhao, W.; Niu, Z.; Ruan, B.; Li, Q.; Zheng, Y.; Wang, C.; Zhou, Y.; Zhang, B.; Zhou, F.; Huang, H.; Shi, H.; Sun, Q.

10.1101/2021.02.26.432996 — cell biology — Posted on 2021-02-26

253 Kasugamycin is a novel chitinase 1 inhibitor with strong antifibrotic effects on pulmonary fibrosis

Lee, J.-H.; Lee, C.-M.; Kim, M.-O.; Park, J. W.; Kamle, S.; Akosman, B.; Herzog, E. L.; Elias, J. A.; Lee, C. G.

10.1101/2021.02.25.432796 — immunology — Posted on 2021-02-26

254 Immunity-longevity tradeoff neurally controlled by GABAergic transcription factor PITX1/UNC-30

Otarigho, B.; Aballay, A.

10.1101/2021.02.25.432801 — immunology — Posted on 2021-02-26

255 Human Astrocytes Exhibit Tumor Microenvironment-, Age-, and Sex-Related Transcriptomic Signatures

Krawczyk, M. C.; Haney, J. R.; Caneda, C.; Khankan, R. R.; Reyes, S. D.; Chang, J. W.; Morselli, M.; Vinters, H. V.; Wang, A. C.; Cobos, I.; Gandal, M. J.; Bergsneider, M.; Kim, W.; Liau, L. M.; Yong, W.; Jalali, A.; Deneen, B.; Grant, G. A.; Mathern, G. W.; Fallah, A.; Zhang, Y.

10.1101/2021.02.25.432948 — neuroscience — Posted on 2021-02-26

256 Early functional and cognitive declines measured by auditory evoked cortical potentials in Alzheimer's disease mice

Mei, L.; Liu, L.-M.; Chen, K.; Zhao, H.-B.

10.1101/2021.02.25.432945 — neuroscience — Posted on 2021-02-26

257 A Mixed-Modeling Framework for Whole-Brain Dynamic Network Analysis

Bahrami, M.; Laurienti, P. J.; Shappell, H. M.; Simpson, S. L.

10.1101/2021.02.25.432947 — neuroscience — Posted on 2021-02-26

258 FrozenChicken: Promoting the meta-analysis of chicken microarray data

Duarte, I.; Liber, M.; Magno, R.; Andrade, R. P.

10.1101/2021.02.25.432894 — bioinformatics — Posted on 2021-02-26

259 Efficient in vivo genome editing mediated by stem cells-derived extracellular vesicles carrying designer nucleases

Bobis-Wozowicz, S.; Kania, K.; Nit, K.; Blazowska, N.; Kmiotek-Wasylewska, K.; Paw, M.; Karnas, E.; Szyposzynska, A.; Tyszka-Czochara, M.; Woznicka, O.; Boruczkowski, D.; Mussolino, C.; Łabaj, P. P.; Schambach, A.; Madeja, Z.; Cathomen, T.; Zuba-Surma, E.

10.1101/2021.02.25.432823 — bioengineering — Posted on 2021-02-26

260 A chicken IgY can efficiently inhibit the entry and replication of SARS-CoV-2 by targeting the ACE2 binding domain in vitro

Jingchen, W.; Yunfei, L.; Ying, R.; Xuanyu, Z.; Songqing, H.; Shuwen, W.; Qing, X.

10.1101/2021.02.16.430255 — immunology — Posted on 2021-02-26

261 COVID-19 Disease Map, a computational knowledge repository of SARS-CoV-2 virus-host interaction mechanisms

Ostaszewski, M.; Niarakis, A.; Mazein, A.; Kuperstein, I.; Phair, R.; Orta-Resendiz, A.; Singh, V.; Aghamiri, S. S.; Acencio, M. L.; Glaab, E.; Ruepp, A.; Fobo, G.; Montrone, C.; Brauner, B.; Frishman, G.; Monraz Gomez, L. C.; Somers, J.; Hoch, M.; Gupta, S. K.; Scheel, J.; Borlinghaus, H.; Czauderna, T.; Schreiber, F.; Montagud, A.; Ponce de Leon, M.; Funahashi, A.; Hiki, Y.; Hiroi, N.; Yamada, T. G.; Drager, A.; Renz, A.; Naveez, M.; Bocskei, Z.; Messina, F.; Bornigen, D.; Fergusson, L.; Conti, M.; Rameil, M.; Nakonecnij, V.; Vanhoefer, J.; Schmiester, L.; Wang, M.; Ackerman, E. E.; Shoemake

10.1101/2020.10.26.356014 — systems biology — Posted on 2021-02-26

262 Could Italy host the new coronavirus before China?

Tichopad, A.; Pecen, L.

10.1101/2021.02.24.432649 — scientific communication and education — Posted on 2021-02-26

263 A systematic analysis of metabolic pathways in the human gut microbiota

Pascal Andreu, V.; Augustijn, H. E.; Chen, L.; Zhernakova, A.; Fu, J.; Fischbach, M. A.; Dodd, D.; Medema, M. H.

10.1101/2021.02.25.432841 — bioinformatics — Posted on 2021-02-26

264 Error correction enables use of Oxford Nanopore technology for reference-free transcriptome analysis

Sahlin, K.; Medvedev, P.

10.1101/2020.01.07.897512 — bioinformatics — Posted on 2021-02-26

265 Bone Mineral Density modelled as a Random Field: a Feasibility Study on Pelvic Bone

Henys, P.; Vorechovsky, M.; Kuchar, M.; Heinemann, A.; Kopal, J.; Ondruschka, B.; Hammer, N.

10.1101/2021.02.25.432881 — biophysics — Posted on 2021-02-26

266 Power analysis of transcriptome-wide association study: implications for practical protocol choice

Cao, C.; Ding, B.; Li, Q.; Kwok, D.; Wu, J.; Long, Q.

10.1101/2020.07.19.211151 — bioinformatics — Posted on 2021-02-26

267 Polygenic Scores for Cognitive Abilities and their Association with Different Aspects of General Intelligence - a Deep Phenotyping Approach

Genc, E.; Schlüter, C.; Fraenz, C.; Arning, L.; Metzen, D.; Nguyen, H. P.; Voelkle, M. C.; Streit, F.; Güntürkün, O.; Kumsta, R.; Ocklenburg, S.

10.1101/2020.06.03.131318 — genetics — Posted on 2021-02-26

268 Capturing single-copy nuclear genes, organellar genomes, and nuclear ribosomal DNA from deep genome skimming data for plant phylogenetics: A case study in Vitaceae

Liu, B.-B.; Ma, Z.-Y.; Ren, C.; Hodel, R. G. J.; Sun, M.; Liu, X.-Q.; LIU, G.-N.; Hong, D.-Y.; Zimmer, E.; Wen, J.

10.1101/2021.02.25.432805 — evolutionary biology — Posted on 2021-02-26

269 Evolution of thermal physiology alters predicted species distributions under climate change

Wuitchik, S. J.; Mogensen, S.; Barry, T. N.; Paccard, A.; Jamniczky, H. A.; Barrett, R. D.; Rogers, S. M.

10.1101/2021.02.25.432865 — ecology — Posted on 2021-02-26

270 Understanding the emergence of contingent and deterministic exclusion in multispecies communities

Song, C.; Uricchio, L. H.; Mordecai, E. A.; Saavedra, S.

10.1101/2020.09.23.310524 — ecology — Posted on 2021-02-26

271 Can we fish on stocks that need rebuilding? Illustrating the trade-offs between stock conservation and fisheries considerations

Trijoulet, V.; Berg, C. W.; Sparrevohn, C. R.; Nielsen, A.; Pastoors, M. A.; Mosegaard, H.

10.1101/2021.02.25.432880 — ecology — Posted on 2021-02-26

272 Size-dependent eco-evolutionary feedbacks in fisheries

Edeline, E.; Loeuille, N.

10.1101/2020.04.03.022905 — ecology — Posted on 2021-02-26

273 Experimental increases in temperature mean and variance alter reproductive behaviors in the dung beetle Phanaeus vindex

Kirkpatrick, W. H.; Sheldon, K. S.

10.1101/2021.02.25.432276 — ecology — Posted on 2021-02-26

274 Commensal Microbiota Regulates Skin Barrier Function And Repair Via Signaling Through The Aryl Hydrocarbon Receptor

Uberoi, A.; Bartow-McKenney, C.; Zheng, Q.; Flowers, L.; Campbell, A.; Knight, S. A. B.; Chan, N.; Wei, M.; Lovins, V.; Bugayev, J.; Horwinski, J.; Bradley, C.; Meyer, J.; Crumrine, D.; Sutter, C. H.; Elias, P.; Mauldin, E.; Sutter, T. R.; Grice, E. A.

10.1101/2020.12.05.413096 — microbiology — Posted on 2021-02-26

275 A new method shows that a minority of liver-localized CD8 T cells display hard-to-detect attraction to Plasmodium-infected hepatocytes

Zenkov, V. S.; O'Connor, J.; McNamara, H.; Cockburn, I. A.; Ganusov, V. V.

10.1101/2020.12.12.422451 — immunology — Posted on 2021-02-26

276 Multisensory integration-attention trade-off in cochlear-implanted deaf individuals

van de Rijt, L. P. H.; van Opstal, J. A.; van Wanrooij, M. M.

10.1101/2020.11.17.384586 — neuroscience — Posted on 2021-02-26

277 Dissociable oscillatory networks support gain and loss processing in human orbitofrontal cortex

Saez, I.; Lin, J.; Chang, E. F.; Parvizi, J.; Knight, R. T.; Hsu, M.

10.1101/2021.02.25.432874 — neuroscience — Posted on 2021-02-26

278 Unsupervised learning of haptic material properties

Metzger, A.; Toscani, M.

10.1101/2021.02.25.432896 — neuroscience — Posted on 2021-02-26

279 Visual object categorization in infancy

Spriet, C.; Abassi, E.; Hochmann, J.-R.; Papeo, L.

10.1101/2021.02.25.432436 — neuroscience — Posted on 2021-02-26

280 Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system

Ramirez, P.; Sun, W.; Zuniga, G.; Ochoa Thomas, E.; DeVos, S.; Hyman, B.; Chiu, G.; Roy, E. R.; Cao, W.; Orr, M.; Buggia-Prevot, V.; Ray, W. J.; Frost, B.

10.1101/2021.02.25.432716 — neuroscience — Posted on 2021-02-26

281 Engineering Gac/Rsm signaling cascade for optogenetic induction of pathogenicity switch in Pseudomonas aeruginosa

Cheng, X.; Pu, L.; Fu, S.; Xia, A.; Huang, S.; Ni, L.; Xing, X.; Yang, S.; JIN, F.

10.1101/2020.10.28.358515 — synthetic biology — Posted on 2021-02-26

282 Withaferin A promotes white adipose browning and prevents obesity through sympathetic nerve-activated Prdm16-FATP1 axis

Zheng, R.; Guo, B.; Liu, J.; Wang, B.; Zhang, C.; Su, Z.; Zhao, M.

10.1101/2021.02.25.432705 — physiology — Posted on 2021-02-26

283 Screening of different cytotoxicity methods for the assessment of ENDS toxicity relative tobacco cigarettes

Caruso, M.; Emma, R.; Rust, S.; Distefano, A.; Carota, G.; Pulvirenti, R.; Polosa, R.; Li Volti, G.

10.1101/2021.02.25.432848 — pharmacology and toxicology — Posted on 2021-02-26

284 A triple threat: the Parastagonospora nodorum SnTox267 effector exploits three distinct host genetic factors to cause disease in wheat

Richards, J. K.; Kariyawasam, Gayan, G.; Seneviratne, S.; Wyatt, N. A.; Xu, S. S.; Liu, Z.; Faris, J. D.; Friesen, T. L. L.

10.1101/2021.02.25.432871 — pathology — Posted on 2021-02-26

285 Scaling concepts in 'omics: nuclear lamin-B scales with tumor growth and predicts poor prognosis, whereas fibrosis can be pro-survival

Vashisth, M.; Discher, D.; Cho, S.; Irianto, J.; Xia, Y.; Wang, M.; Hayes, B.; Jafarpour, F.; Liu, A.; Wells, R. G.

10.1101/2021.02.25.432860 — cancer biology — Posted on 2021-02-26

286 Imprints of tumor mutation burden on chromosomes and relation to cancer risk in humans: A pan-cancer analysis

Li, X.; Thirumalai, D.

10.1101/2020.04.20.050989 — cancer biology — Posted on 2021-02-26

287 Addressing the Embeddability Problem in Transition Rate Estimation

Goolsby, C.; Losey, J.; Xu, Y.; Düker, M.-C.; Getmansky Sherman, M.; Matteson, D.; Moradi, M.

10.1101/707919 — biophysics — Posted on 2021-02-26

288 Pipeline to detect the relationship between transposable elements and adjacent genes in host genome

Meguerditchian, C.; Ergun, A.; DECROOCQ, V.; LEFEBVRE, M.; Bui, Q. T.

10.1101/2021.02.25.432867 — bioinformatics — Posted on 2021-02-26

289 Development of a label-free microfluidic impedimetric immunoassay for anti-SPAG16 antibody.

Froyen, T.; Vreys, F.; Thoelen, R.; Slaets, L.; Somers, V.

10.1101/2021.02.25.432859 — bioengineering — Posted on 2021-02-26

290 Multilamellar mesoporous silica nanoparticles using a cationic co-surfactant dual-templating method.

Froyen, T.; Froyen, T.; Vounckx, U.; Hardy, A.

10.1101/2021.02.25.432869 — bioengineering — Posted on 2021-02-26

291 Underlying environmental factors and geomagnetic fields linked to 45 pilot whales Globicephala macrorhynchus stranding in Modung white beach, Indonesian coast on 19th February 2021

Wibowo, A. A.

10.1101/2021.02.25.432840 — ecology — Posted on 2021-02-26

292 Different underlying mechanisms for high and low arousal in probabilistic learning in humans

Ciria, L. F.; Suarez-Pinilla, M.; Williams, A. G.; Jagannathan, S. R.; Sanabria, D.; Bekinschtein, T. A.

10.1101/2021.02.26.431959 — neuroscience — Posted on 2021-02-26

293 Sensory and cognitive factors affecting multi-digit touch: a perceptual and modeling study

Arslanova, I.; Takamuku, S.; Gomi, H.; Haggard, P.

10.1101/2021.02.25.432852 — neuroscience — Posted on 2021-02-26

294 Long-range promoter-enhancer contacts are conserved during evolution and contribute to gene expression robustness

Laverre, A.; Tannier, E.; Necsulea, A.

10.1101/2021.02.26.432473 — evolutionary biology — Posted on 2021-02-26

295 Cell Type Assignments for Spatial Transcriptomics Data

Teng, H.; Yuan, Y.; Bar-Joseph, Z.

10.1101/2021.02.25.432887 — bioinformatics — Posted on 2021-02-26

296 Using optogenetics to link myosin patterns to contractile cell behaviors during convergent extension

Herrera-Perez, R. M.; Cupo, C.; Allan, C.; Lin, A.; Kasza, K. E.

10.1101/2021.02.25.432882 — developmental biology — Posted on 2021-02-26

297 Individual-based simulations of genome evolution with ancestry: the GENOMEADMIXR R package

Janzen, T.; Diaz, F.

10.1101/2020.10.19.343491 — bioinformatics — Posted on 2021-02-26

298 The novel, recurrent mutation in the TOP2A gene results in the enhanced topoisomerase activity and transcription deregulation in glioblastoma

Gielniewski, B.; Poleszak, K.; Roura, A.-J.; Szadkowska, P.; Krol, S. K.; Guzik, R.; Wiechecka, P.; Maleszewska, M.; Kaza, B.; Marchel, A.; Czernicki, T.; Koziarski, A.; Zielinski, G.; Styk, A.; Kawecki, M.; Szczylik, C.; Czepko, R.; Banach, M.; Kaspera, W.; Szopa, W.; Bujko, M.; Czapski, B.; Zabek, M.; Izycka-Swieszewska, E.; Kloc, W.; Nauman, P.; Cieslewicz, J.; Wojtas, B.; Kaminska, B.

10.1101/2020.06.17.158477 — cancer biology — Posted on 2021-02-26

299 Fitting quantum machine learning potentials to experimental free energy data: Predicting tautomer ratios in solution

Wieder, M.; Fass, J.; Chodera, J. D.

10.1101/2020.10.24.353318 — biophysics — Posted on 2021-02-26

300 Addressing the Embeddability Problem in Transition Rate Estimation

Goolsby, C.; Losey, J.; Xu, Y.; Düker, M.-C.; Getmansky Sherman, M.; Matteson, D.; Moradi, M.

10.1101/707919 — biophysics — Posted on 2021-02-26

301 Niche evolution of the Neotropical tree genus Otoba in the context of global biogeography of the nutmeg family, Myristicaceae

Frost, L. A.; Santamaria-Aguilar, D. A.; Singletary, D.; Lagomarsino, L. P.

10.1101/2020.10.02.324368 — evolutionary biology — Posted on 2021-02-26

302 Causal approach to environmental risks of seabed mining

Kaikkonen, L.; Helle, I.; Kostamo, K.; Kuikka, S.; Nygard, H.; Törnroos, A.; Venesjärvi, R.; Uusitalo, L.

10.1101/2021.02.21.432138 — ecology — Posted on 2021-02-26

303 Translesion DNA synthesis-driven mutagenesis in very early embryogenesis of fast cleaving embryos

Lo Furno, E.; Busseau, I.; Lorenzi, C.; Saghira, C.; Zuchner, S.; Maiorano, D.

10.1101/2020.11.28.401471 — developmental biology — Posted on 2021-02-26

304 Exploring the interaction network of a synthetic gut bacterial community

Weiss, A. S.; Burrichter, A. G.; Chakravarthy Durai Raj, A.; von Strempel, A.; Meng, C.; Kleigrewe, K.; Münch, P. C.; Rössler, L.; Huber, C.; Eisenreich, W.; Jochum, L. M.; Göing, S.; Jung, K.; Sanchez, A.; Stecher, B.

10.1101/2021.02.25.432904 — microbiology — Posted on 2021-02-26

305 Improving stroke detection via Correlation Tensor MRI

Alves, R.; Henriques, R. N.; Kerkela, L.; Chavarrias, C.; Jespersen, S.; Shemesh, N.

10.1101/2021.02.20.432088 — neuroscience — Posted on 2021-02-26

306 Self-contained and modular structured illumination microscope

Van den Eynde, R.; Vandenberg, W.; Hugelier, S.; Bouwens, A.; Hofkens, J.; Müller, M.; Dedecker, P.

10.1101/2021.02.25.432746 — biophysics — Posted on 2021-02-25

307 Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects

Lin, Y.; Grinter, S. Z.; Lu, Z.; Xu, X.; Wang, H. Z.; Liang, H.; Hou, P.; Gao, J.; Clausen, C.; Shi, J.; Zhao, W.; Ma, Z.; Liu, Y.; White, K. M.; Zhao, L.; Kang, P.-W.; Zhang, G.; Cohen, I. S.; Zou, X.; Cui, J.

10.1101/2021.02.25.432939 — biophysics — Posted on 2021-02-25

308 Metabolomics of aging in primary fibroblasts from small and large breed dogs

Brookes, P. S.; Jimenez, A. G.

10.1101/2021.02.25.432888 — cell biology — Posted on 2021-02-25

309 Rab11-dependent recycling of calcium channels is mediated by auxiliary subunit α2δ-1 but not α2δ-3

Meyer, J. O.; Dolphin, A. C.

10.1101/2021.02.25.432839 — neuroscience — Posted on 2021-02-25

310 Misinformation, Perceptions Towards COVID-19 and Willingness to be Vaccinated: A Population-Based Survey in Yemen

Bitar, A. N.; Zawiah, M.; Al-Ashwal, F. Y.; Kubas, M.; Saeed, R. M.; Abduljabbar, R.; Jaber, A. A. S.; Sulaiman, S. A. S.; Khan, A. H.

10.1101/2021.02.25.432838 — scientific communication and education — Posted on 2021-02-25

311 Frequent PIK3CA mutations in eutopic endometrium of patients with ovarian clear cell carcinoma

Murakami, K.; Kanto, A.; Sakai, K.; Miyagawa, C.; Takaya, H.; Nakai, H.; Kotani, Y.; Nishio, K.; Matsumura, N.

10.1101/2021.02.25.432943 — cancer biology — Posted on 2021-02-25

312 A precise and general FRET-based method for monitoring structural transitions in protein self-organization

Wan, Q.; Mouton, S. N.; Veenhoff, L. M.; Boersma, A. J.

10.1101/2021.02.25.432866 — biophysics — Posted on 2021-02-25

313 Intrinsic Gating Behavior of Voltage-Gated Sodium Channels Predetermines Regulation by Auxiliary β-subunits

Brake, N.; Mancino, A. S.; Yan, Y.; Shimomura, T.; Silveira, H.; Kubo, Y.; Khadra, A.; Bowie, D.

10.1101/2021.02.25.432706 — biophysics — Posted on 2021-02-25

314 Ear wound healing in MRL/MpJ mice is associated with gut microbiome composition and is transferable to non-healer mice via microbiome transplantation

Velasco, C.; Dunn, C.; Sturdy, C.; Izda, V. A.; Martin, J. A.; Rivas, A.; McNaughton, J.; Jeffries, M. A.

10.1101/2021.02.25.432835 — molecular biology — Posted on 2021-02-25

315 A simple and robust method for automating analysis of naïve and regenerating peripheral nerves

Wong, A. L.; Hricz, N.; Malapati, H.; von Guionneau, N.; Wong, M. J.; Harris, T.; Boudreau, M.; Cohen-Adad, J.; Tuffaha, S.

10.1101/2021.02.25.432836 — neuroscience — Posted on 2021-02-25

316 A functional logic for neurotransmitter co-release in the cholinergic forebrain pathway

Nair, A.; Graf, M.; Teo, Y. Y.; Augustine, G. J.

10.1101/2021.02.25.432623 — neuroscience — Posted on 2021-02-25

317 Pax3 induces neural circuit repair through a developmental program of directed axon outgrowth.

Jara, J. S.; Avci, H. X.; Kouremenou, J.; Doulazmi, M.; Bakouche, J.; Dubacq, C.; Goyenvalle, C.; Mariani, J.; Lohof, A. M.; Sherrard, R. M.

10.1101/2021.02.25.432898 — neuroscience — Posted on 2021-02-25

318 Stratified Random Sampling Methodology for Observing Community Mask Use within Indoor Settings: Results from Louisville, Kentucky during the COVID-19 Pandemic

KARIMI, S. M.; Salunkhe, S. S.; White, K. B.; Little, B. M.; McKinney, W. P. M.; Mitra, R. M.; Chen, Y. M.; Adkins, E. R.; Barclay, J. A.; Ezekekwu, E. M.; He, C. X.; Hurst, D. M.; Popescu, M. M. M.; Swinney, D. N.; Johnson, D. A.; Hollenbach, R. M.; Moyer, S. M.; DuPre, N. R.

10.1101/2021.02.25.432837 — scientific communication and education — Posted on 2021-02-25

319 Nothing in evolution makes sense except in the light of parasites

Hickinbotham, S. J.; Stepney, S.; Hogeweg, P.

10.1101/2021.02.25.432891 — evolutionary biology — Posted on 2021-02-25

320 Different historical generation intervals in human populations inferred from Neanderthal fragment lengths and patterns of mutation accumulation

Coll Macia, M.; Skov, L.; Peter, B. M.; Schierup, M. H.

10.1101/2021.02.25.432907 — evolutionary biology — Posted on 2021-02-25

321 Complex trait-environment relationships underlie the structure of Wisconsin forest plant communities

Rolhauser, A. G.; Waller, D. M.; Tucker, C. M.

10.1101/2020.11.17.387050 — ecology — Posted on 2021-02-25

322 Age-related dedifferentiation and hyperdifferentiation of perceptual and mnemonic representations

Deng, L.; Davis, S. W.; Monge, Z. A.; Wing, E. A.; Geib, B. R.; Raghunandan, A.; Cabeza, R.

10.1101/2020.06.15.151217 — neuroscience — Posted on 2021-02-25

323 Elucidation of Japanese pepper (Zanthoxylum piperitum De Candolle) domestication using RAD-Seq

Premarathne, M. D. G. P.; Fukutome, N.; Yamasaki, K.; Hayakawa, F.; Nagano, A. J.; Mizuno, H.; Ibaragi, N.; Nagano, Y.

10.1101/2020.12.29.424752 — plant biology — Posted on 2021-02-25

324 CINS: Cell Interaction Network inference from Single cell expression data

Yuan, Y.; Cosme, C.; Adams, T. S.; Schupp, J.; Sakamoto, K.; Xylourgidis, N.; Ruffalo, M.; Kaminski, N.; Bar-Joseph, Z.

10.1101/2021.02.22.432206 — bioinformatics — Posted on 2021-02-25

325 Agency rescues competition for credit assignment among predictive cues from adverse learning conditions

Kang, M.; Reverte, I.; Volz, S. G.; Kaufman, K.; Fevola, S.; Matarazzo, A.; Alhazmi, F. H.; Marquez, I.; Iordanova, M. D.; Esber, G. R.

10.1101/2021.02.24.432808 — animal behavior and cognition — Posted on 2021-02-25

326 Regulation of DNA (de)methylation positively impacts seed germination during seed development under heat stress

Malabarba, J.; Windels, D.; Xu, W.; Verdier, J.

10.1101/2021.02.25.432822 — molecular biology — Posted on 2021-02-25

327 A minimal rDNA array replicates early, delays genome replication, and uncouples anaphase entry from S phase completion

Kwan, E. X.; Alvino, G. M.; Lynch, K. L.; Levan, P. F.; Amemiya, H. M.; Wang, X. S.; Johnson, S. A.; Sanchez, J. C.; Miller, M. A.; Croy, M.; Lee, S.-b. B.; Naushab, M.; Cuperus, J.; Brewer, B. J.; Queitsch, C.; Raghuraman, M. K.

10.1101/2021.02.25.432950 — molecular biology — Posted on 2021-02-25

328 Exploring the interaction network of a synthetic gut bacterial community

Weiss, A. S.; Burrichter, A. G.; Chakravarthy Durai Raj, A.; von Strempel, A.; Meng, C.; Kleigrewe, K.; Muench, P. C.; Roessler, L.; Huber, C.; Eisenreich, W.; Jochum, L. M.; Goeing, S.; Jung, K.; Sanchez, A.; Stecher, B.

10.1101/2021.02.25.432904 — microbiology — Posted on 2021-02-25

329 The plant immune receptors NRG1.1 and ADR1 are calcium influx channels

Jacob, P. M.; Kim, N. H.; Wu, F.; El Kasmi, F. M.; Walton, W. G.; Furzer, O. J.; Lietzen, A. D.; Sunil, S.; Kempthorn, K.; Redinbo, M.; Pei, Z.-M.; Wan, L.; Dangl, J. L.

10.1101/2021.02.25.431980 — plant biology — Posted on 2021-02-25

330 FrustratometeR: an R-package to compute Local frustration in protein structures, point mutants and MD simulations

Rausch, A. O.; Freiberger, M. I.; Leonetti, C. O.; Luna, D. M.; Radusky, L. G.; Wolynes, P. G.; Ferreiro, D. U.; Parra, R. G.

10.1101/2020.11.26.400432 — bioinformatics — Posted on 2021-02-25

331 DeepCellState: an autoencoder-based framework for prediction of cell type specific transcriptional states induced by drug treatment

Umarov, R.; Li, Y.; Arner, E.

10.1101/2020.12.14.422792 — bioinformatics — Posted on 2021-02-25

332 Positional and Compositional Analysis of Saturated, Monounsaturated and Polyunsaturated Fatty acids in Human Adipose Tissue Triglyceride by 13C NMR

Nunez Torres, A. P.; Tavares, L.; Pereira, M. J.; Eriksson, J. W.; Jones, J. G.

10.1101/2021.02.25.432655 — biochemistry — Posted on 2021-02-25

333 The cis-regulatory effects of modern human-specific variants

Weiss, C. V.; Harshman, L.; Inoue, F.; Fraser, H. B.; Petrov, D. A.; Ahituv, N.; Gokhman, D.

10.1101/2020.10.07.330761 — evolutionary biology — Posted on 2021-02-25

334 Genomic phylogeography of the White-crowned Manakin Pseudopipra pipra (Aves: Pipridae) illuminates a continental-scale radiation out of the Andes

Berv, J. S.; Campagna, L.; Feo, T. J.; Castro-Astor, I.; Ribas, C. C.; Prum, R. O.; Lovette, I. J.

10.1101/713081 — evolutionary biology — Posted on 2021-02-25

335 Mechanically Sensitive HSF1 is a Key Regulator of Left-Right Symmetry Breaking in Zebrafish Embryos

Du, j.; Li, S. K.; Guan, L.-Y.; Guo, Z.; Yin, J.-F.; Gao, L.; Kawanishi, T.; Shimada, A.; Zhang, Q.-p.; Zheng, L.-S.; Liu, Y.-Y.; Feng, X.-X.; Chen, D.-Y.; Takeda, H.; Fan, Y.

10.1101/2021.02.25.432863 — developmental biology — Posted on 2021-02-25

336 The type 2 asthma mediator IL-13 inhibits SARS-CoV-2 infection of bronchial epithelium

Bonser, L. R.; Eckalbar, W. L.; Rodriguez, L.; Shen, J.; Koh, K. D.; Zlock, L. T.; Christenson, S.; Woodruff, P. G.; Finkbeiner, W. E.; Erle, D. J.

10.1101/2021.02.25.432762 — cell biology — Posted on 2021-02-25

337 Pyroptosis of syncytia formed by fusion of SARS-CoV-2 Spike and ACE2 expressing cells

Ma, H.; Zhu, Z.; Lin, H.; Wang, S.; Zhang, P.; Li, Y.; Li, L.; Wang, J.; Zhao, Y.; Han, J.

10.1101/2021.02.25.432853 — cell biology — Posted on 2021-02-25

338 ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation

van der Weegen, Y.; de Lint, K.; van den Heuvel, D.; Nakazawa, Y.; Narayanan, I. V.; Klaassen, N. H. M.; Wondergem, A. P.; Roohollahi, K.; van Schie, J. J. M.; Hara, Y.; Ljungman, M.; Ogi, T.; Wolthuis, R. M. F.; Luijsterburg, M. S.

10.1101/2021.02.25.432427 — molecular biology — Posted on 2021-02-25

339 A microRNA program controls the transition of cardiomyocyte hyperplasia to hypertrophy and stimulates mammalian cardiac regeneration

Raso, A.; Dirkx, E.; Sampaio-Pinto, V.; el Azzouzi, H.; Cubero, R. J.; Sorensen, D.; Ottaviani, L.; Olieslagers, S.; Huibers, M.; de Weger, R.; Siddiqi, S.; Moimas, S.; Torrrini, C.; Zentillin, L.; Braga, L.; da Costa Martins, P. A.; van Berlo, J. H.; Zaccigna, S.; Giacca, M.; De Windt, L. J.

10.1101/2021.02.25.432908 — molecular biology — Posted on 2021-02-25

340 Epithelial and neutrophil interactions and innate immune response to Shigella in a human intestinal enteroid-neutrophil co-culture

Lemme-Dumit, J. M.; Doucet, M.; Zachos, N.; Pasetti, M. F.

10.1101/2020.09.03.281535 — immunology — Posted on 2021-02-25

341 MtrA regulation of essential peptidoglycan cleavage in Mycobacterium tuberculosis during infection

Peterson, E. J. R.; Brooks, A. N.; Reiss, D. J.; Kaur, A.; Wu, W.-J.; Morrison, R.; Srinivas, V.; Turkarslan, S.; Pan, M.; Carter, W.; Arrieta-Ortiz, M. L.; Ruiz, R. A.; Bhatt, A.; Baliga, N. S.

10.1101/2021.02.25.432019 — systems biology — Posted on 2021-02-25

342 Low nitrogen availability inhibits the phosphorus starvation response in maize (Zea mays ssp. mays L.)

Torres-Rodriguez, J. V.; Salazar-Vidal, M. N.; Chavez Montes, R. A.; Massange-Sanchez, J. A.; Gillmor, C. S.; Sawers, R. J. H.

10.1101/2020.10.29.360487 — plant biology — Posted on 2021-02-25

343 The immunosuppression of macrophages underlies the cardioprotective effects of catestatin (CST)

Ying, W.; Tang, K.; Avolio, E.; Schilling, J. M.; Pasqua, T.; Liu, M. A.; Cheng, H.; Gao, H.; Zhang, J.; Mahata, S.; Ko, M. S.; Bandyopadhyay, G. K.; Das, S.; Roth, D. M.; Sahoo, D.; Webster, N. J.; Sheikh, F.; Ghosh, G.; Patel, H. H.; Ghosh, P.; Bogaart, G. v. d.; Mahata, S. K.

10.1101/2020.05.12.092254 — physiology — Posted on 2021-02-25

344 Systems biology analysis identifies TCF7L1 as a key regulator of metastasis in Ewing sarcoma

Cidre-Aranaz, F.; Li, J.; Hoelting, T. L. B.; Orth, M. F.; Imle, R.; Kutschmann, S.; Ammirati, G.; Ceranski, K.; Carreno-Gonzalez, M. J.; Kasan, M.; Marchetto, A.; Funk, C. M.; Bestvater, F.; Bersini, S.; Arrigoni, C.; Moretti, M.; Romero-Perez, L.; Banito, A.; Ohmura, S.; Musa, J.; Kirchner, T.; Knott, M. M. L.; Gruenewald, T. G. P.

10.1101/2021.02.25.432862 — cancer biology — Posted on 2021-02-25

345 The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma.

Pan, M.; Wright, C.; Chapple, R.; Zubair, A.; Sandhu, M.; Batchelder, J.; Low, J.; Blankenship, K.; Wang, L.; Gordon, B.; Archer, P.; Brady, S. W.; Natarajan, S.; Pozsgai, M.; Schuetz, J.; Miller, D.; Kalathur, R.; chen, s.; Connelly, P.; Babu, M.; Dyer, M. A.; Pruett-Miller, S. M.; Freeman, B.; Chen, T.; Godley, L.; Blanchard, S.; Stewart, E.; Easton, J.; Geeleher, P.

10.1101/2021.02.25.432934 — cancer biology — Posted on 2021-02-25

346 ARYL HYDROCARBON RECEPTOR BLOCKS AGING-INDUCED SENESCENCE IN THE LIVER AND FIBROBLAST CELLS

Nacarino Palma, A.; Rico Leo, E. M.; Campisi, J.; Ramanathan, A.; Merino, J. M.; Fernandez-Salguero, P. M.

10.1101/2021.02.25.432074 — cancer biology — Posted on 2021-02-25

347 Chronos: a CRISPR cell population dynamics model

Dempster, J. M.; Boyle, I.; Vazquez, F.; Root, D. E.; Boehm, J. S.; Hahn, W. C.; Tsherniak, A.; McFarland, J.

10.1101/2021.02.25.432728 — bioinformatics — Posted on 2021-02-25

348 Polyvalent Guide RNAs for CRISPR Antivirals

Bagchi, R.; Tinker-Kulberg, R.; Supakar, T.; Chamberlain, S.; Ligaba-Osena, A.; Josephs, E. A.

10.1101/2021.02.25.430352 — bioengineering — Posted on 2021-02-25

349 Termination of DNA replication at Tus-ter barriers results in under-replication of template DNA

Jameson, K. H.; Rudolph, C. J.; Hawkins, M.

10.1101/2021.02.25.432933 — biochemistry — Posted on 2021-02-25

350 Decoupling the bridge helix of Cas12a results in a reduced trimming activity and impaired conformational transitions

Woerle, E.; Jakob, L.; Schmidbauer, A.; Zinner, G.; Grohmann, D.

10.1101/2021.02.25.432845 — biochemistry — Posted on 2021-02-25

351 A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2

Delorey, T. M.; Ziegler, C. G. K.; Heimberg, G.; Normand, R.; Yang, Y.; Segerstolpe, A.; Abbondanza, D.; Fleming, S. J.; Subramanian, A.; Montoro, D. T.; Jagadeesh, K. A.; Dey, K.; Sen, P.; Slyper, M.; Pita-Juarez, Y.; Phillips, D.; Bloom-Ackermann, Z.; Barkas, N.; Ganna, A.; Gomez, J.; Normandin, E.; Naderi, P.; Popov, Y. V.; Raju, S. S.; Niezen, S.; Tsai, L. T.- Y.; Siddle, K. J.; Sud, M.; Tran, V. M.; Karuthedath Vellarikkal, S.; Amir-Zilberstein, L.; Atri, D. S.; Beechem, J. M.; Brook, O. R.; Chen, J.; Divakar, P.; Dorceus, P.; Engreitz, J. M.; Essene, A.; Fitzgerald, D. M.; Fropf, R.; Gaz

10.1101/2021.02.25.430130 — genomics — Posted on 2021-02-25

352 Low-input ATAC&mRNA-Seq: a simple and robust method for simultaneous dual-omics profiling with low cell number

Li, R.; Grimm, S. A.; Wade, P. A.

10.1101/2021.02.25.432879 — genomics — Posted on 2021-02-25

353 Wolbachia in the spittlebug Prosapia ignipectus: Variable infection frequencies, but no apparent effect on host reproductive isolation

Wheeler, T. B.; Thompson, V.; Conner, W. R.; Cooper, B. S.

10.1101/2021.02.25.432892 — evolutionary biology — Posted on 2021-02-25

354 Apolar mode of gastrulation leads to the formation of polarized larva in a marine hydroid, Dynamena pumila

Vetrova, A. A.; Lebedeva, T. S.; Saidova, A. A.; Kupaeva, D. M.; Kraus, Y. A.; Kremnyov, S. V.

10.1101/2021.02.25.432844 — developmental biology — Posted on 2021-02-25

355 The CCL2 Chemokine Promotes Early Seeding of the Latent HIV Reservoir

Packard, T.; Schwarzer, R.; Herzig, E.; Rao, D.; Luo, X.; Egedal, J.; Hsiao, F.; Widera, M.; Hultquist, J. F.; Grimmett, Z. W.; Messer, R. J.; Krogan, N. J.; Deeks, S.; Roan, N. R.; Dittmer, U.; Hasenkrug, K. J.; Greene, W. C.

10.1101/2021.02.25.432826 — cell biology — Posted on 2021-02-25

356 Versatile Cell-Based Assay for Measuring Base Excision Repair of DNA Alkylation Damage

Czaja, W.; Li, Y.; Mao, P.; Basenko, E.; Lewis, Z. A.; Smerdon, M.

10.1101/2021.02.25.432902 — molecular biology — Posted on 2021-02-25

357 High-resolution, genome-wide mapping of positive supercoiling in chromosomes

Guo, M. S.; Littlehale, M. L.; Kawamura, R.; Marko, J. F.; Laub, M. T.

10.1101/2021.02.25.432897 — molecular biology — Posted on 2021-02-25

358 Endoribonuclease activity of XRN-2 is critical for RNA metabolism and survival of Caenorhabditis elegans

Sardar, M.; Samajdar, A.; Wani, A. R.; Chatterjee, S.

10.1101/2021.02.25.432855 — molecular biology — Posted on 2021-02-25

359 Structural and molecular characterization of the Rpv3 locus towards the development of KASP markers for downy mildew resistance in grapevine (Vitis spp.)

Wairich, A.; Malabarba, J.; Buffon, V.; Porto, D. D.; Togawa, R.; Revers, L. F.

10.1101/2021.02.25.432814 — molecular biology — Posted on 2021-02-25

360 Comparison of the pathogenicity and virus shedding of SARS CoV-2 VOC 202012/01 and D614G variant in hamster model

Mohandas, S.; Yadav, P. D.; Nyayanit, D.; Deshpande, G.; Aich, A. S.; Sapkal, G.; Kumar, S.; Jain, R.; Kadam, M.; Kumar, A.; Patil, D. Y.; Sarkale, P.; Gawande, P.; Abraham, P.

10.1101/2021.02.25.432136 — microbiology — Posted on 2021-02-25

361 Metagenomic sequencing reveals a lack of virus exchange between native and invasive freshwater fish across the Murray-Darling Basin, Australia

Costa, V. A.; Mifsud, J. C. O.; Gilligan, D.; Williamson, J. E.; Holmes, E. C.; Geoghegan, J. L.

10.1101/2021.02.25.432824 — microbiology — Posted on 2021-02-25

362 Proanthocyanidin-enriched cranberry extract induces resilient bacterial community dynamics in a gnotobiotic mouse model

Neto, C. C.; Mortzfeld, B. M.; Turbitt, J. R.; Bhattarai, S. K.; Yeliseyev, V.; DiBenedetto, N.; Bry, L. M.; Bucci, V.

10.1101/2021.02.25.432903 — microbiology — Posted on 2021-02-25

363 Aerobic growth physiology of Saccharomyces cerevisiae on sucrose is strain-dependent

Rodrigues, C. I. S.; Wahl, A.; Gombert, A. K.

10.1101/2021.02.25.432870 — microbiology — Posted on 2021-02-25

364 Human breast milk enhances intestinal mucosal barrier function and innate immunity in a pediatric human enteroid model

Noel, G.; In, J.; Lemme-Dumit, J. M.; DeVine, L. R.; Cole, R. N.; Guerrerio, A. L.; Kovbasnjuk, O.; Pasetti, M. F.

10.1101/2021.02.17.431653 — immunology — Posted on 2021-02-25

365 Tissue-resident, extravascular CD64-Ly6C- population forms a critical barrier for inflammation in the synovium

Montgomery, A. B.; Chen, S.-Y.; Gadhvi, G.; Mayr, M. G.; Cuda, C. M.; Dominguez, S.; Makinde, H. M.; Misharin, A.; Gurra, M. G.; AKBARPOUR, M.; Bharat, A.; Bundinger, G. R. S.; Winter, D. R.; Perlman, H.

10.1101/2021.02.25.432850 — immunology — Posted on 2021-02-25

366 Defining kinetic roles of transcriptional activators in the early Drosophila embryo

Harden, T. T.; Vincent, B. J.; DePace, A. H.

10.1101/2021.02.25.432925 — systems biology — Posted on 2021-02-25

367 A crosswalk to align the GSS and NIH grants databases based on university names

Pickett, C. L.

10.1101/2021.02.25.432534 — scientific communication and education — Posted on 2021-02-25

368 Regulation of plasmodesmata at specific cell-cell interfaces

Li, Z.; Aung, K.

10.1101/2021.02.25.432931 — plant biology — Posted on 2021-02-25

369 Vascular and renal telomere shortening in mice exposed to chronic intermittent hypoxia

Mohammad, B.; Abuyassin, B.; Ayas, N.; Sin, D.; Laher, I.

10.1101/2021.02.25.432912 — physiology — Posted on 2021-02-25

370 Neurological mechanism of sensory deficits after developmental exposure to non-dioxin-like polychlorinated biphenyls (PCBs) in zebrafish larvae

Brun, N. R.; Panlilio, J. M.; Zhang, K.; Zhao, Y.; Ivashkin, E.; Stegeman, J.; Goldstone, J.

10.1101/2021.02.14.430009 — pharmacology and toxicology — Posted on 2021-02-25

371 Transposable elements as sensors of SARS-CoV-2 infection

Sorek, M.; Meshorer, E.; Schlesinger, S.

10.1101/2021.02.25.432821 — bioinformatics — Posted on 2021-02-25

372 Antiviral Resistance against Viral Mutation: Praxis and Policy for SARS CoV-2

Penner, R. C.

10.1101/2021.02.25.432861 — bioinformatics — Posted on 2021-02-25

373 The Diameter Factor of Aligned Electrospinning Membranes Facilitates Cutaneous Wound Healing by Promoting Epithelialization

Wang, C.; Chu, C.; Zhao, X.; Hu, C.; Liu, L.; Li, J.; Qu, Y.; Man, Y.

10.1101/2021.02.25.432929 — bioengineering — Posted on 2021-02-25

374 Natural selections on both amino acid sequences and expression levels are determinants of ohnolog retention

Miao, L.; Li, M.

10.1101/2021.02.24.432806 — evolutionary biology — Posted on 2021-02-25

375 Evolutionary Genetic Species Detected in Prokaryotes by Applying the K/θ Ratio to DNA Sequences

Birky, C. W.; Maughan, H.

10.1101/2020.04.27.062828 — evolutionary biology — Posted on 2021-02-25

376 SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc- SMPDL3B

Li, X.; Fan, W.; Tang, S.; Fan, X.; Fang, Y.; Xu, X.; Li, L.; Xu, J.; Li, J.-L.; Wang, Z.

10.1101/2021.02.24.432815 — cell biology — Posted on 2021-02-25

377 Local Accumulation of Axonal Mitochondria in the Optic Nerve Glial Lamina Precedes Myelination

Wilkison, S. J.; Bright, C. L.; Vancini, R.; Song, D. J.; Bomze, H. M.; Cartoni, R.

10.1101/2021.02.25.432924 — neuroscience — Posted on 2021-02-25

378 Brain Morphometry and Diminished Physical Growth in Bangladeshi Children Growing up in Extreme Poverty: a Longitudinal Study

Turesky, T. K.; Shama, T.; Kakon, S. H.; Haque, R.; Someshwar, A.; Islam, N.; Petri, W.; Nelson, C. A.; Gaab, N.

10.1101/2021.02.24.432797 — neuroscience — Posted on 2021-02-25

379 Odor Blocking Of Stress

Lee, E. J.; Saraiva, L. R.; Hanchate, N. K.; Ye, X.; Asher, G.; Ho, J.; Buck, L. B.

10.1101/2021.02.24.432809 — neuroscience — Posted on 2021-02-25

380 Data-driven learning how oncogenic gene expression locally alters heterocellular networks

Klinke, D. J.; Fernandez, A.; Deng, W.; Latifizadeh, H.; Pirkey, A. C.

10.1101/2020.05.04.077107 — systems biology — Posted on 2021-02-25

381 An integrated multi-wavelength SCATTIRSTORM microscope combining TIRFM and IRM modalities for imaging cellulases and other processive enzymes

Nong, D.; Haviland, Z. K.; Vasquez Kuntz, K. O.; Tien, M.; Anderson, C. T.; Hancock, W. O.

10.1101/2021.02.25.432940 — biophysics — Posted on 2021-02-25

382 Genome-wide survey of odorant-binding proteins in the dwarf honey bee Apis florea

Mam, B.; Karpe, S. D.; Sowdhamini, R.

10.1101/2021.02.25.432941 — bioinformatics — Posted on 2021-02-25

383 Agency rescues competition for credit assignment among predictive cues from adverse learning conditions

Kang, M.; Reverte, I.; Volz, S. G.; Kaufman, K.; Fevola, S.; Matarazzo, A.; Alhazmi, F. H.; Marquez, I.; Iordanova, M. D.; Esber, G. R.

10.1101/2021.02.24.432808 — animal behavior and cognition — Posted on 2021-02-25

384 Identification of mutations associated with Macozinone-resistant in Mycobacterium Tuberculosis

Chen, X.; Li, Y.; Wang, B.; Lu, Y.

10.1101/2021.02.24.432818 — molecular biology — Posted on 2021-02-25

385 Sequence-function relationships in phage-encoded bacterial cell wall lytic enzymes and their implications for phage-derived products design

Vazquez, R.; Garcia, E.; Garcia, P.

10.1101/2021.02.23.432618 — microbiology — Posted on 2021-02-25

386 Elucidation of fibril structure responsible for swimming in Spiroplasma using electron microscopy

Sasajima, Y.; Kato, T.; Miyata, T.; Namba, K.; Miyata, M.

10.1101/2021.02.24.432793 — microbiology — Posted on 2021-02-25

387 Dual mechanisms of opioid-induced respiratory depression in the inspiratory rhythm generating network

Baertsch, N. A.; Bush, N. E.; Burgraff, N. J.; Ramirez, J.-M.

10.1101/2021.02.24.432816 — neuroscience — Posted on 2021-02-25

388 HDAC6 promote HCCLM3 cell migration and invasion by regulating TGF-β1pathway

Yu, Z.; Xiaoxiao, Y.; Guowen, Y.

10.1101/2021.02.23.432488 — biochemistry — Posted on 2021-02-25

389 ExOrthist: a tool to infer exon orthologies at any evolutionary distance

Marquez, Y.; Mantica, F.; Cozzuto, L.; Burguera, D.; Hermoso-Pulido, A.; Ponomarenko, J.; Roy, S. W.; Irimia, M.

10.1101/2021.02.22.432358 — genomics — Posted on 2021-02-25

390 Genetic variation in haemoglobin regulates breathing in high-altitude deer mice

Ivy, C. M.; Wearing, O.; Natarajan, C.; Schweizer, R. M.; Gutierrez-Pinto, N.; Velotta, J. P.; Campbell-Staton, S. C.; Petersen, E. E.; Fago, A.; Cheviron, Z. A.; Storz, J. F.; Scott, G. R.

10.1101/2021.02.23.432531 — evolutionary biology — Posted on 2021-02-25

391 The Functional Significance of Bacterial Predators

Hungate, B. A.; Marks, J. C.; Power, M. E.; Schwartz, E.; van Groenigen, K. J.; Blazewicz, S. J.; Chuckran, P. F.; Dijkstra, P.; Finley, B. K.; Firestone, M. K.; Foley, M. M.; Greenlon, A.; Hayer, M.; Hofmockel, K.; Koch, B. J.; Mack, M. C.; Mau, R. L.; Miller, S. N.; Morrissey, E. M.; Propster, J. R.; Purcell, A. M.; Sieradzki, E. T.; Starr, E. P.; Stone, B. W. G.; Terrer, C.; Pett-Ridge, J.

10.1101/2021.02.22.432408 — ecology — Posted on 2021-02-25

392 Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism

Concha, M.; Pulgar, E.; Schwayer, C.; Guerrero, N.; Lopez, L.; Marquez, S.; Härtel, S.; Soto, R.; Heisenberg, C.-P.

10.1101/2021.02.24.432660 — developmental biology — Posted on 2021-02-25

393 Miltefosine enhances infectivity of miltefosine-resistant Leishmania infantum by attenuating innate immune recognition

Bulte, D.; Van Bockstal, L.; Dirkx, L. W.; Van den Kerkhof, M.; De Trez, C.; Timmermans, J.-P.; Hendrickx, S.; Maes, L.; Caljon, G.

10.1101/2021.02.22.432409 — microbiology — Posted on 2021-02-25

394 Cervical Squamous Intraepithelial Lesions are Associated with Changes in the Vaginal Microbiota of Mexican Women

Nieves-Ramirez, M.; Partida-Rodriguez, O.; Moran-Silva, P.; Serrano-Vazquez, A.; Perez-Juarez, H.; Perez-Rodriguez, M. E.; Arrieta, M. C.; Ximenez-Garcia, C.; Finlay, B. B.

10.1101/2021.02.23.432613 — microbiology — Posted on 2021-02-25

395 Expression patterns of Plasmodium falciparum clonally variant genes at the onset of a blood infection in non-immune humans

Pickford, A. K.; Michel-Todo, L.; Dupuy, F.; Mayor, A.; Alonso, P.; Lavazec, C.; Cortes, A.

10.1101/2021.02.23.432621 — microbiology — Posted on 2021-02-25

396 Bacterial Cytological Profiling Identifies Rhodanine-containing PAINS Analogs as Specific Inhibitors of E. coli Thymidylate Kinase in Vivo

Montano, E. T.; Nideffer, J. F.; Sugie, J.; Enustun, E.; Shapiro, A. B.; Tsunemoto, H.; Derman, A.; Pogliano, K.; Pogliano, J.

10.1101/2021.02.22.432404 — microbiology — Posted on 2021-02-25

397 Comparative genomics analysis of Chryseobacterium sp. KMC2 reveals metabolic pathways involved in keratinous utilization and natural product biosynthesis

Kang, D.; Shoaie, S.; Jacquiod, S.; Sorensen, S. J.; Ledesma-Amaro, R.

10.1101/2021.02.23.432615 — microbiology — Posted on 2021-02-25

398 Can we harness digital technologies and physiology to hasten genetic gain in U.S. maize breeding?

Diepenbrock, C. H.; Tang, T.; Jines, M.; Technow, F.; Lira, S.; Podlich, D.; Cooper, M.; Messina, C. D.

10.1101/2021.02.23.432477 — plant biology — Posted on 2021-02-25

399 High Affinity Chimeric Antigen Receptor with Cross-Reactive scFv to Clinically Relevant EGFR Oncogenic Isoforms

Thokala, R.; Binder, Z. A.; Yin, Y.; Zhang, L.; Zhang, J. V.; Zhang, D. Y.; Milone, M. C.; Ming, G.-L.; Song, H.; O'Rourke, D. M.

10.1101/2021.02.04.429797 — cancer biology — Posted on 2021-02-25

400 macroH2A2 shapes chromatin accessibility at enhancer elements in glioblastoma to modulate a targetable self-renewal epigenetic network

Nikolic, A.; Bobyn, A.; Maule, F.; Ellestad, K.; Lun, X.; Johnston, M.; Gafuik, C.; Zemp, F.; Paik, S.; Ninkovic, N.; Marhon, S.; Mehdipour, P.; Shen, Y.; Berger, D.; Brownsey, D.; Dirks, P.; Derksen, D.; Jones, S.; de Carvalho, D.; Senger, D.; Chan, J.; Mahoney, D.; Gallo, M.

10.1101/2021.02.23.432465 — cancer biology — Posted on 2021-02-25

401 SMILE: Mutual Information Learning for Integration of Single Cell Omics Data

Xu, Y.; Das, P.; McCord, R. P.

10.1101/2021.01.28.428619 — bioinformatics — Posted on 2021-02-25

402 A behavioral syndrome linking boldness and flexibility facilitates invasion success in sticklebacks

Bensky, M.; Bell, A.

10.1101/2021.02.06.430052 — animal behavior and cognition — Posted on 2021-02-25

403 Repulsive electrostatic interactions modulate dense and dilute phase properties of biomolecular condensates

Crabtree, M. D.; Holland, J.; Kompella, P. S.; Babl, L.; Turner, N. N.; Baldwin, A. J.; Nott, T. J.

10.1101/2020.10.29.357863 — cell biology — Posted on 2021-02-25

404 Longitudinal high-resolution imaging through a flexible intravital imaging window

Jacquemin, G.; Benavente-Diaz, M.; Djaber, S.; Bore, A.; Dangles-Marie, V.; Surdez, D.; Tajbakhsh, S.; Fre, S.; Lloyd-Lewis, B.

10.1101/2021.02.24.432491 — cell biology — Posted on 2021-02-25

405 Hippocampal sharp wave-ripples and the associated sequence replay emerge from structured synaptic interactions in a network model of area CA3

Ecker, A.; Bagi, B.; Vertes, E.; Steinbach-Nemeth, O.; Karlocai, M. R.; Papp, O. I.; Miklos, I.; Hajos, N.; Freund, T. F.; Gulyas, A. I.; Kali, S.

10.1101/2021.02.18.431868 — neuroscience — Posted on 2021-02-25

406 Turing's diffusive threshold in random reaction-diffusion systems

Haas, P. A.; Goldstein, R. E.

10.1101/2020.11.09.374934 — biophysics — Posted on 2021-02-25

407 Set-Min sketch: a probabilistic map for power-law distributions with application to k-mer annotation

Shibuya, Y.; Belazzougui, D.; Kucherov, G.

10.1101/2020.11.14.382713 — bioinformatics — Posted on 2021-02-25

408 Domestication effects on immune response: comparison of cell-mediated immune competence in wild and domesticated Bengalese finch

Suzuki, K.; Okanoya, K.

10.1101/2021.02.24.432813 — zoology — Posted on 2021-02-25

409 Postembryonic development of the two-spotted field cricket (Gryllus bimaculatus): a staging system

Neiro, J.

10.1101/2021.02.24.432775 — zoology — Posted on 2021-02-25

410 Elementary growth modes/vectors and minimal autocatalytic sets for kinetic/constraint-based models of cellular growth

Müller, S.

10.1101/2021.02.24.432769 — systems biology — Posted on 2021-02-25

411 Modeling SARS-CoV-2 nsp1-5'-UTR complex via the extended ensemble simulations

Sakuraba, S.; Qilin, X.; Kasahara, K.; Iwakiri, J.; Kono, H.

10.1101/2021.02.24.432807 — biophysics — Posted on 2021-02-25

412 Towards a systematic characterization of protein complex function: a natural language processing and machine-learning framework

Sharma, V. S.; Fossati, A.; Ciuffa, R.; Buljan, M.; Williams, E. G.; Chen, Z.; Shao, W.; Pedrioli, P. G. A.; Purcell, A. W.; Rodriguez Martinez, M.; Song, J.; Manica, M.; Aebersold, R.; Li, C.

10.1101/2021.02.24.432789 — bioinformatics — Posted on 2021-02-25

413 Visualization of SARS-CoV-2 Infection Scenes by 'Zero-Shot' Enhancements of Electron Microscopy Images

Drefs, J.; Salwig, S.; Lücke, J.

10.1101/2021.02.25.432265 — bioinformatics — Posted on 2021-02-25

414 Transcriptogram analysis reveals relationship between viral titer and gene set responses during Corona-virus infection.

de Almeida, R. M. C.; Thomas, G. L.; Glazier, J. A.

10.1101/2020.06.16.155267 — bioinformatics — Posted on 2021-02-25

415 The evolutionary history of a gammaretrovirus currently colonizing the mule deer genome is marked by extensive recombination

Yang, L.; Malhotra, R.; Chikhi, R.; Elleder, D.; Kaiser, T.; Rong, J.; Medvedev, P.; Poss, M.

10.1101/2021.02.24.432774 — genomics — Posted on 2021-02-25

416 Larvae and adults exhibit contrasting patterns of immune gene expression and infection resistance in wild flour beetle populations

Tate, A. T.; Perry, A.; Jent, D. G.

10.1101/2021.02.24.432795 — evolutionary biology — Posted on 2021-02-25

417 Genetic and epigenetic determinants of reactivation of Mecp2 and the inactive X chromosome in neural stem cells.

Mira-Bontenbal, H.; Tan, B.; Gontan, C.; Goossens, S.; Boers, R. G.; Boers, J. B.; Dupont, C.; van Royen, M. E.; van IJcken, W.; French, P.; Bedalov, A.; Gribnau, J. M.

10.1101/2021.02.25.432827 — molecular biology — Posted on 2021-02-25

418 Parallel evolution of a splicing program controlling neuronal excitability in flies and mammals

Torres-Mendez, A.; Pop, S.; Bonnal, S.; Almudi, I.; Roberts, R. J. V.; Paolantoni, C.; Alcaina, A.; Avola, A.; Martin Anduaga, A.; Haussmann, I. H.; Morin, V.; Soller, M.; Kadener, S.; Roignant, J.-Y.; Prieto-Godino, L.; Irimia, M.

10.1101/2021.02.24.432780 — molecular biology — Posted on 2021-02-25

419 In situ single-cell activities of microbial populations revealed by spatial transcriptomics

Dar, D.; Dar, N.; Cai, L.; Newman, D. K.

10.1101/2021.02.24.432792 — microbiology — Posted on 2021-02-25

420 NADPH Oxidase 2 Derived Reactive Oxygen Species Promote CD8+ T cell Effector Function

Chen, J.; Liu, C.; Chernatynskaya, A.; Newby, B. N.; Brusko, T. M.; Xu, X.; Morgan, N.; Santarlas, C. P.; Reeves, W. H.; Tse, H. M.; Leiding, J. W.; Mathews, C. E.

10.1101/2021.02.24.432756 — immunology — Posted on 2021-02-25

421 Binocular vs. monocular recovery experience differentially promote recovery from visual deficits in a mouse model of amblyopia

Martinez, J. D.; Donnelly, M. J.; Popke, D.; Torres, D.; Sheskey, S.; Clawson, B. C.; Jiang, S.; Aton, S.

10.1101/2021.02.24.432698 — neuroscience — Posted on 2021-02-25

422 Investigation of the temporal and spatial dynamics of muscular action potentials through optically pumped magnetometers.

Broser, P.; Marquetand, J.; Middelmann, T.; Somettid, D.; Braun, C.

10.1101/2021.02.24.432771 — neuroscience — Posted on 2021-02-25

423 Decoding the brain state-dependent relationship between pupil dynamics and resting state fMRI signal fluctuation

Sobczak, F.; Pais-Roldan, P.; Takahashi, K.; Yu, X.

10.1101/2021.02.24.432768 — neuroscience — Posted on 2021-02-25

424 Automatic recognition of macaque facial expressions for detection of affective states

Morozov, A.; Parr, L.; Gothard, K. M.; Paz, R.; Pryluk, R.

10.1101/2021.02.24.432760 — neuroscience — Posted on 2021-02-25

425 Spatiospectral brain networks reflective of improvisational experience

Faller, J.; Goldman, A. J.; Lin, Y.; McIntosh, J. R.; Sajda, P.

10.1101/2021.02.25.432633 — neuroscience — Posted on 2021-02-25

426 Influence of High Concentrations of Copper Sulfate on In Vitro Adventitious Organogenesis of Cucumis sativus L.

Miguel, J. F.

10.1101/2021.02.24.432794 — plant biology — Posted on 2021-02-25

427 Progranulin promotes immune evasion of pancreatic adenocarcinoma through regulation of MHCI expression

Cheung, P. F.; Yang, J.; Krengel, K.; Althoff, K.; Yip, C.; Siu, E. H.; Ng, L. W.; Lang, K. S.; Cham, L.; Engel, D. R.; Soun, C.; Cima, I.; Scheffler, B.; Striefler, J. K.; Sinn, M.; Bahra, M.; Pelzer, U.; Oettle, H.; Markus, P.; Smeets, E. M.; Aarntzen, E. H.; Savvatakis, K.; Liffers, S.-T.; Neander, C.; Bazarna, A.; Zhang, X.; Paschen, A.; Crawford, H. C.; Chan, A. W.; Cheung, S. T.; Siveke, J. T.

10.1101/2021.02.24.432700 — cancer biology — Posted on 2021-02-25

428 Cancer cell-specific MHCII expression as a determinant of the immune infiltrate organization and function in the non-small cell lung cancer tumor microenvironment

Johnson, A. M.; Boland, J. M.; Wrobel, J. L.; Klezcko, E. K.; Weisner-Evans, M. L.; Heasley, L.; Clambey, E. T.; Nemenoff, R. L.; Schenk, E. L.

10.1101/2021.02.24.432729 — cancer biology — Posted on 2021-02-25

429 Efficient Agony Based Transfer Learning Algorithms for Survival Forecasting

Tamaskar, A.; Bannon, J.; Mishra, B.

10.1101/2021.02.24.432695 — cancer biology — Posted on 2021-02-25

430 Stratification Of Chemotherapy-Treated Stage III Colorectal Cancer Patients Using Multiplexed Imaging And Single Cell Analysis Of T Cell Populations

Stachtea, X.; Loughrey, M. B.; Salvucci, M.; Lindner, A.; Cho, S.; McDonough, E.; Sood, A.; Graf, J.; Santamaria-Pang, A.; Corwin, A.; Laurent-Puig, P.; Dasgupta, S.; Van Schaeybroeck, S.; Lawler, M.; Prehn, J. H. M.; Ginty, F.; Longley, D. B.

10.1101/2021.02.24.432210 — cancer biology — Posted on 2021-02-25

431 Identical Sequences, Different Behaviors: ProteinDiversity Captured at the Single-Molecule Level

Tapia-Rojo, R.; Alonso-Caballero, A.; Badilla, C. L.; Fernandez, J.

10.1101/2021.02.24.432730 — biophysics — Posted on 2021-02-25

432 SnapKin: a snapshot deep learning ensemble for kinase-substrate prediction from phosphoproteomics data

Lin, M.; Xiao, D.; Geddes, T. A.; Burchfield, J. G.; Parker, B.; Humphrey, S. J.; Yang, P.

10.1101/2021.02.23.432610 — bioinformatics — Posted on 2021-02-25

433 merlin v4.0: an updated platform for the reconstruction of high-quality genome-scale metabolic models

Capela, J.; Lagoa, D.; Rodrigues, R.; Cunha, E.; Cruz, F.; Barbosa, A.; Bastos, J.; Lima, D.; Ferreira, E. C.; Rocha, M.; Dias, O.

10.1101/2021.02.24.432752 — bioinformatics — Posted on 2021-02-25

434 SIMILE enables alignment of fragmentation mass spectra with statistical significance

Treen, D. G.; Northen, T. R.; Bowen, B.

10.1101/2021.02.24.432767 — bioinformatics — Posted on 2021-02-25

435 Myo-inositol Oxygenase Overexpression Rescues Vitamin C Deficient Arabidopsis (vtc) Mutants

Acosta-Gamboa, L. M.; Nepal, N.; Medina-Jimenez, K.; Campbell, Z. C.; Cunningham, S. S.; Lee, J. A.; Lorence, A.

10.1101/2021.02.24.432757 — biochemistry — Posted on 2021-02-25

436 Intra-helical salt bridge contribution to membrane protein insertion

Duart, G.; Lamb, J.; Elofsson, A.; Mingarro, I.

10.1101/2021.02.24.432724 — biochemistry — Posted on 2021-02-25

437 Characterising ontogeny of numerosity discrimination in zebrafish reveals multiple, numerical and non- numerical mechanisms.

Sheardown, E.; Torres-Perez, J. V.; Anagianni, S.; Fraser, S.; Vallortigara, G.; Butterworth, B.; Miletto-Petrazzini, M. E.; Brennan, C. H.

10.1101/2021.02.25.432846 — animal behavior and cognition — Posted on 2021-02-25

438 De novo assembly and annotation of a highly contiguous reference genome of the fathead minnow (Pimephales promelas) reveals an AT-rich repetitive genome with compact gene structure

Martinson, J.; Bencic, D. C.; Toth, G. P.; Kostich, M. S.; Lattier, D.; See, M. J.; Biales, A. D.; Huang, W.

10.1101/2021.02.24.432777 — genomics — Posted on 2021-02-25

439 Natural Selection as the Sum over all Histories and a Differential Equation for Environmental Coevolution.

Neal-Sturgess, C. E.

10.1101/2021.02.24.432748 — evolutionary biology — Posted on 2021-02-25

440 Extensive duplication and convergent sequence evolution of an antimicrobial peptide gene

Hanson, M. A.; Lemaitre, B.

10.1101/2021.02.24.432738 — evolutionary biology — Posted on 2021-02-25

441 Towns and Trails Drive Carnivore Connectivity using a Step Selection Approach

Whittington, J.; Baron, R.; Hebblewhite, M.; Ford, A. T.; Paczkowski, J.

10.1101/2021.02.24.432739 — ecology — Posted on 2021-02-25

442 Rats spontaneously perceive global motion direction of drifting plaids

Matteucci, G.; Zattera, B.; Bellacosa Marotti, R.; Zoccolan, D.

10.1101/2021.02.24.432732 — neuroscience — Posted on 2021-02-25

443 Catching a liar through facial expression of fear

Shen, X.; Fan, G.; Niu, C.; Chen, Z.

10.1101/2021.02.24.432646 — neuroscience — Posted on 2021-02-25

444 Prolonged epigenetic and synaptic plasticity alterations following single exposure to a psychedelic in mice

de la Fuente Revenga, M.; Zhu, B.; Guevara, C. A.; Naler, L. B.; Saunders, J. M.; Zhou, Z.; Toneatti, R.; Sierra, S.; Wolstenholme, J. T.; Beardsley, P. M.; Huntley, G. W.; Lu, C.; Gonzalez-Maeso, J.

10.1101/2021.02.24.432725 — neuroscience — Posted on 2021-02-25

445 Extracellular S100B alters spontaneous Ca2+ fluxes in dopaminergic neurons via L-type voltage gated calcium channels: Implications for Parkinson's disease

Bancroft, E. A.; Pandey, G.; Zarate, S. M.; Srinivasan, R.

10.1101/2021.02.24.432751 — neuroscience — Posted on 2021-02-25

446 Outcomes of Progranulin Gene Therapy in the Retina are Dependent on Time of Delivery

Zin, E. A.; Han, D.; Tran, J.; Morrison-Welch, N.; Visel, M.; Kuronen, M.; Flannery, J. G.

10.1101/2021.02.24.432570 — neuroscience — Posted on 2021-02-25

447 Modelling seeding and neuroanatomic spread of pathology in amyotrophic lateral sclerosis

Pandya, S.; Maia, P.; Freeze, B.; Menke, R.; Talbot, K.; Turner, M.; Raj, A.

10.1101/2021.02.24.431118 — neuroscience — Posted on 2021-02-25

448 DYRK1A role in microtubule-based axonal transport regulates the retrograde dynamics of APP vesicles in human neurons

Fernandez Bessone, I.; Karmirian, K.; Goto-Silva, L.; Holubiec, M.; Navarro, J. L.; Martinez, E.; Saez, T. M.; Rehen, S.; Falzone, T. L.

10.1101/2021.02.25.432601 — neuroscience — Posted on 2021-02-25

449 Urea nitrogen recycling via gut symbionts increases in hibernators over the winter fast

Regan, M. D.; Chiang, E.; Liu, Y.; Tonelli, M.; Verdoorn, K. M.; Gugel, S. R.; Suen, G.; Carey, H. V.; Assadi-Porter, F. M.

10.1101/2021.02.24.432731 — physiology — Posted on 2021-02-25

450 Predictive visuo-motor communication through neural oscillations

Benedetto, A.; Binda, P.; Costagli, M.; Tosetti, M.; Morrone, M. C.

10.1101/2020.07.28.224949 — neuroscience — Posted on 2021-02-25

451 Short hydrogen bonds enhance non-aromatic protein-related fluorescence

Stephens, A. D.; Qaisrani, M. N.; Ruggiero, M. T.; Miron, G. D.; Morzan, U.; Gonzalez Lebrero, M. C.; Jones, S. T. E.; Poli, E.; Bond, A. D.; Woodhams, P. J.; Kleist, E. M.; Grisanti, L.; Gebauer, R.; Zeitler, J. A.; Credgington, D.; Hassanali, A.; Kaminski Schierle, G. S.

10.1101/2020.01.22.915306 — biophysics — Posted on 2021-02-25

452 Estimating abundance and phenology from transect count data with GLMs

Edwards, C. B.; Crone, E. E.

10.1101/2020.06.01.127910 — ecology — Posted on 2021-02-25

453 Translesion DNA synthesis-driven mutagenesis in very early embryogenesis of fast cleaving embryos

Lo Furno, E.; Busseau, I.; Lorenzi, C.; Saghira, C.; Zuchner, S.; Maiorano, D.

10.1101/2020.11.28.401471 — developmental biology — Posted on 2021-02-25

454 Disease specific alterations in the olfactory mucosa of patients with Alzheimer's disease

Lampinen, R.; Fazaludeen, M. F.; Avesani, S.; Örd, T.; Penttilä, E.; Lehtola, J.-M.; Saari, T.; Hannonen, S.; Saveleva, L.; Kaartinen, E.; Acosta, F. F.; Cruz-Haces, M.; Löppönen, H.; Mackay-Sim, A.; Malm, T.; Kaikkonen-Maatta, M.; Koivisto, A.; White, A. R.; Giugno, R.; Chew, S.; Kanninen, K. M.

10.1101/2020.11.24.395947 — neuroscience — Posted on 2021-02-25

455 Branched-Chain Amino Acid Metabolism is Regulated by ERRα in Primary Human Myotubes and is Further Impaired by Glucose Loading in Type 2 Diabetes

Sjögren, R. J. O.; Rizo-Roca, D.; Chibalin, A. V.; Chorell, E.; Furrer, R.; Katayama, S.; Harada, J.; Karlsson, H. K. R.; Handschin, C.; Moritz, T.; Krook, A.; Näslund, E.; Zierath, J. R.

10.1101/2020.07.24.218099 — physiology — Posted on 2021-02-25

456 Identification of biomarkers and candidate inhibitors for multiple myeloma

Gu, H.; Wang, W.; Yuan, G.

10.1101/2021.02.25.432847 — bioinformatics — Posted on 2021-02-25

457 Disentangling age-dependent DNA methylation: deterministic, stochastic, and nonlinear

Vershinina, O.; Bacalini, M. G.; Zaikin, A.; Franceschi, C.; Ivanchenko, M.

10.1101/2020.10.07.329987 — systems biology — Posted on 2021-02-25

458 Integrative inference of transcriptional networks in Arabidopsis yields novel ROS signalling regulators

De Clercq, I.; Van de Velde, J.; Luo, X.; Liu, L.; Storme, V.; Van Bel, M.; Pottie, R.; Vaneechoutte, D.; Van Breusegem, F.; vandepoele, K.

10.1101/2020.08.11.245902 — plant biology — Posted on 2021-02-25

459 Gene Ontology Meta Annotator for Plants (GOMAP)

Wimalanathan, K.; Lawrence-Dill, C. J.

10.1101/809988 — bioinformatics — Posted on 2021-02-25

460 Domestication effects on aggressiveness: Comparison of biting motivation and bite force between wild and domesticated finches

Suzuki, K.; Okanoya, K.

10.1101/2021.02.24.432800 — animal behavior and cognition — Posted on 2021-02-25

461 Processing of novel food reveal payoff and rank-biased social learning in a wild primate

Canteloup, C.; Biff Cera, M.; Barrett, B. J.; van de Waal, E.

10.1101/2020.09.25.313437 — animal behavior and cognition — Posted on 2021-02-25

462 Polyploidy-associated paramutation in Arabidopsis is determined by small RNAs, temperature, and allele structure

Bente, H.; Foerster, A. M.; Lettner, N.; Mittelsten Scheid, O.

10.1101/2020.10.21.348839 — genetics — Posted on 2021-02-25

463 Dimerisation of APOBEC1 is dispensable for its RNA/DNA editing activity and modulates its availability

Chieca, M.; Montini, M. D.; Severi, F.; Lembo, G.; Donati, F.; Pecori, R.; Conticello, S. G.

10.1101/410803 — molecular biology — Posted on 2021-02-25

464 Toroidal topology of population activity in grid cells

Gardner, R. J.; Hermansen, E.; Pachitariu, M.; Burak, Y.; Baas, N. A.; Dunn, B. J.; Moser, M.-B.; Moser, E. I.

10.1101/2021.02.25.432776 — neuroscience — Posted on 2021-02-25

465 Local DNA shape is a general principle of transcription factor binding specificity in Arabidopsis thaliana

Sielemann, J.; Wulf, D.; Schmidt, R.; Braeutigam, A.

10.1101/2020.09.29.318923 — plant biology — Posted on 2021-02-25

466 Effects of scent enrichment on behavioural andphysiological indicators of stress in zoo primates

Vaglio, S.; Kaburu, S.; Young, C.; Pearce, R.; Smith, S.; Tompkins, B. E.; Elwell, E.; Fontani, S.; Marliani, G.; Accorsi, P. A.

10.1101/2020.08.21.260679 — animal behavior and cognition — Posted on 2021-02-25

467 Parasitic success and venom composition evolve upon specialization of parasitoid wasps to different host species

Cavigliasso, F.; Mathe-Hubert, H.; Gatti, J.-L.; Colinet, D.; Poirie, M.

10.1101/2020.10.24.353417 — evolutionary biology — Posted on 2021-02-25

468 Late-life fitness gains explain the absence of a selection shadow in ants

Jaimes Nino, L. M.; Heinze, J.; Oettler, J.

10.1101/2021.02.24.432699 — evolutionary biology — Posted on 2021-02-25

469 Role of endopeptidases in peptidoglycan synthesis mediated by alternative cross-linking enzymes in Escherichia coli

Voedts, H.; Dorchene, D.; Lodge, A.; Vollmer, W.; Arthur, M.; Hugonnet, J.-E.

10.1101/2021.02.12.430937 — microbiology — Posted on 2021-02-25

470 A mixture of generative models strategy helps humans generalize across tasks

HERCE CASTANON, S.; Cardoso-Leite, P.; Green, C. S.; Altarelli, I.; Schrater, P.; Bavelier, D.

10.1101/2021.02.16.431506 — neuroscience — Posted on 2021-02-25

471 Whole-body plethysmography revisited

Hülsmann, S.; Khan, A.; Hagos, L.; Hindermann, M.; Nägel, T.; Dullin, C.

10.1101/2021.02.24.432470 — physiology — Posted on 2021-02-25

472 Toxicity Profile of Artesunate in Rats and Dogs

Lang, J. S.

10.1101/2021.02.16.431559 — pharmacology and toxicology — Posted on 2021-02-25

473 Structural analysis of Sulfolobus solfataricus TF55β chaperonin in open and filamentous states

Zeng, Y. C.; Sobti, M.; Stewart, A. G.

10.1101/2020.01.13.905216 — biophysics — Posted on 2021-02-25

474 Activation of Cytochrome C Peroxidase Function Through Coordinated Foldon Loop Dynamics upon Interaction with Anionic Lipids

Li, M.; Sun, W.; Tyurin, V. A.; DeLucia, M.; Ahn, J.; Kagan, V. E.; van der Wel, P. C. A.

10.1101/2021.02.24.432556 — biophysics — Posted on 2021-02-25

475 REVA as a Well-curated Database for Human Expression-modulating Variants

Wang, Y.; Shi, F.-Y.; Liang, Y.; Gao, G.

10.1101/2021.02.24.432622 — bioinformatics — Posted on 2021-02-25

476 scMoC: Single-Cell Multi-omics clustering

elTager, M.; Abdelaal, T.; Mahfouz, A.; Reinders, M.

10.1101/2021.02.24.432644 — bioinformatics — Posted on 2021-02-25

477 Unsupervised Clustering characterizes the CPG dinucleotides distribution of the Andes hantavirus

Mastriani, E.; Liu, S.-L.

10.1101/2021.02.23.432596 — bioinformatics — Posted on 2021-02-25

478 sweetD: An R package using Hoeffding's D statistic to visualise the dependence between M and A for large numbers of gene expression samples

Barton, A. J.

10.1101/2021.02.24.432640 — bioinformatics — Posted on 2021-02-25

479 Hidden information on protein function in censuses of proteome foldedness

Cox, D.; Ang, C.-S.; Nillegoda, N. B.; Reid, G. E.; Hatters, D. M.

10.1101/2021.02.24.432609 — biochemistry — Posted on 2021-02-25

480 Comparison study of sixteen differential abundance methods using two large Parkinson disease gut microbiome datasets

Wallen, Z. D.

10.1101/2021.02.24.432717 — genomics — Posted on 2021-02-25

481 An integrated approach to identify environmental modulators of genetic risk factors for complex traits

Balliu, B.; Carcamo Orive, I.; Gloudemans, M. J.; Nachun, D. C.; Durrant, M. G.; Gazal, S.; Park, C. Y.; Knowles, D. A.; Wabitsch, M.; Quertermous, T.; Knowles, J. W.; Montgomery, S. B.

10.1101/2021.02.23.432608 — genomics — Posted on 2021-02-25

482 Dynamic expression of smRNA from fecal exosome in disease progression of an inflammatory bowel disorder mouse model.

Manning, S.; Torii, S.; Atkins, H. M.; Kawasawa, Y. I.

10.1101/2021.02.24.432648 — genomics — Posted on 2021-02-25

483 A high-quality Genome and Comparison of Short versus Long Read Transcriptome of the Palaearctic duck Aythya fuligula (Tufted Duck)

Mueller, R. C.; Ellström, P.; Howe, K.; Uliano-Silva, M.; Kuo, R. I.; Miedzinska, K.; Warr, A.; Fedrigo, O.; Haase, B.; Mountcastle, J.; Chow, W.; Torrance, J.; Wood, J.; Järhult, J. D.; Naguib, M. M.; Olsen, B.; Jarvis, E. D.; Smith, J.; Eöry, L.; Kraus, R. H.

10.1101/2021.02.24.432697 — genomics — Posted on 2021-02-25

484 Social aging: Late-life fitness gains explain the absence of a selection shadow in ants

Jaimes Nino, L. M.; Heinze, J.; Oettler, J.

10.1101/2021.02.24.432699 — evolutionary biology — Posted on 2021-02-25

485 The origin and drivers of Neotropical plant and tetrapod diversification

Meseguer, A. S.; Michel, A.; Fabre, P.-H.; Perez-Escobar, O.; Chomicki, G.; Riina, R.; Antonelli, A.; Antoine, P.-O.; Delsuc, F.; Condamine, F.

10.1101/2021.02.24.432517 — evolutionary biology — Posted on 2021-02-25

486 Alternative developmental and transcriptomic responses to host plant water limitation in a butterfly metapopulation

Kahilainen, A.; Oostra, V.; Somervuo, P.; Minard, G.; Saastamoinen, M.

10.1101/2021.02.24.432453 — ecology — Posted on 2021-02-25

487 What is the evidence available to support our knowledge about threats to the conservation of Galliformes in the Greater Himalaya?

Gupta, G.; Grainger, M.; Dunn, J. C.; Sanderson, R.; McGowan, P. J.

10.1101/2021.02.23.432604 — ecology — Posted on 2021-02-25

488 Pathogen and endophyte assemblages co-vary with beech bark disease progression, tree decline, and regional climate

Morrison, E. W.; Kasson, M.; Heath, J.; Garnas, J.

10.1101/2021.02.24.432696 — ecology — Posted on 2021-02-25

489 Downregulation of Extraembryonic Tension Controls Body Axis Formation in Avian Embryos

Kunz, D.; Wang, A.; Chan, C. U.; Pritchard, R. H.; Wang, W.; Gallo, F.; Bradshaw, C. R.; Terenzani, E.; Müller, K. H.; Huang, Y. Y. S.; Xiong, F.

10.1101/2021.02.24.432525 — developmental biology — Posted on 2021-02-25

490 A mouse model of occult intestinal colonization demonstrating antibiotic-induced outgrowth of carbapenem-resistant Enterobacteriaceae

Sim, C. K.; Saheb Kashaf, S.; Conlan, S.; Stacy, A.; Proctor, D. M.; Almeida, A.; Bouladoux, N.; Chen, M.; NISC Comparative Sequencing Program, ; Finn, R. D.; Belkaid, Y.; Segre, J. A.

10.1101/2021.02.24.432587 — microbiology — Posted on 2021-02-25

491 The immunophilin protein FKBPL and its peptide derivatives are novel regulators of vascular integrity and inflammation via NF-kappaB signaling

Annett, S. L.; Spence, S.; Garciarena, C.; Campbell, C.; Dennehy, M.; Drakeford, C.; Lai, J.; Dowling, J.; Moore, G.; Yakkundi, A.; Short, A.; Sharpe, D.; Furlong, F.; O'Donnell, J.; Cavalleri, G.; Kerrigan, S.; Tikhonova, I.; Johnson, P.; Kissenpfennig, A.; Robson, T.

10.1101/2021.02.24.431422 — immunology — Posted on 2021-02-25

492 Power spectra reveal distinct BOLD resting-state time courses in white matter

Li, M.; Gao, Y.; Ding, Z.; Gore, J. C.

10.1101/2021.02.24.432346 — neuroscience — Posted on 2021-02-25

493 More comprehensive proprioceptive stimulation of the hand amplifies its cortical processing

Hakonen, M.; Nurmi, T.; Vallinoja, J.; Jaatela, J.; Piitulainen, H.

10.1101/2021.02.24.432547 — neuroscience — Posted on 2021-02-25

494 A synaptic novelty signal in the dentate gyrus supports switching hippocampal attractor networks from generalization to discrimination

Gomez-Ocadiz, R.; Trippa, M.; Posani, L.; Cocco, S.; Monasson, R.; Schmidt-Hieber, C.

10.1101/2021.02.24.432612 — neuroscience — Posted on 2021-02-25

495 An Adeno-Associated Viral vector encoding Neurotrophin 3 injected into affected forelimb muscles modestly improves sensorimotor function after contusive mid-cervical spinal cord injury.

Sydney-Smith, J. D.; Megaro, V.; Spejo, A. B.; Moon, L. D. F.

10.1101/2021.02.24.432676 — neuroscience — Posted on 2021-02-25

496 Human blood lipoprotein predictions from 1H NMR spectra: protocol, model performances and cage of covariance

Khakimov, B.; C.J. Hoefsloot, H.; Mobaraki, N.; Aru, V.; Kristensen, M.; V. Lind, M.; Holm, L.; L Castro Mejia, J.; Nielsen, D. S.; Jacobs, D. M.; Smilde, A. K.; Engelsen, S. B.

10.1101/2021.02.24.432509 — systems biology — Posted on 2021-02-25

497 Optimized cDICE for efficient reconstitution of biological systems in giant unilamellar vesicles

Van de Cauter, L.; Fanalista, F.; van Buren, L.; De Franceschi, N.; Godino, E.; Bouw, S.; Danelon, C.; Dekker, C.; Koenderink, G. H.; Ganzinger, K. A.

10.1101/2021.02.24.432456 — synthetic biology — Posted on 2021-02-25

498 Disruption of the mitochondrial gene orf352 partially restores pollen development in cytoplasmic male sterile rice

Omukai, S.; Arimura, S.-i.; Toriyama, K.; Kazama, T.

10.1101/2021.02.24.432723 — plant biology — Posted on 2021-02-25

499 Evaluation of dsRNA delivery methods for targeting macrophage migration inhibitory factor MIF in RNAi-based aphid control

Liu, S.; Ladera, M.; Poranen, M. M.; van Bel, A. J.; Kogel, K.-H.; Imani, J.

10.1101/2021.02.24.432707 — plant biology — Posted on 2021-02-25

500 The mitochondrial pyruvate carrier (MPC) complex is one of three pyruvate-supplying pathways that sustain Arabidopsis respiratory metabolism

Le, X.; Lee, C. P.; Millar, A. H.

10.1101/2021.02.24.432685 — plant biology — Posted on 2021-02-25

501 Characterization of growth and development of sorghum genotypes with differential susceptibility to Striga hermonthica

Kawa, D.; Taylor, T.; Thiombiano, B.; Musa, Z.; Vahldick, H.; Walmsley, A. J.; Bucksch, A. K.; Bouwmeester, H.; Brady, S. M.

10.1101/2021.02.24.432663 — plant biology — Posted on 2021-02-25

502 Metabolic characteristics of taste differences under the soil and hydroponic cultures of sweet potato leaves by using non-targeted metabolomics

Lin, Z.; Li, G.; Zhang, H.; Ji, R.; Xu, Y.; Xu, G.; Li, H.; Liu, Z.; Luo, W.; Qiu, Y.; Qiu, S.; Tang, H.

10.1101/2021.02.24.432602 — plant biology — Posted on 2021-02-25

503 Disrupted circadian core-clock oscillations in Type 2 Diabetes are linked to altered rhythmic mitochondrial metabolism

Gabriel, B. M.; Altintas, A.; Smith, J. A. B.; Sardon Puig, L.; Zhang, X.; Linde Basse, A.; Laker, R. C.; Gao, H.; Liu, Z.; Dollet, L.; Treebak, J. T.; Zorzano, A.; Huo, Z.; Ryden, M.; Lanner, J. T.; Esser, K. A.; Barres, R.; Pillon, N. J.; Krook, A.; Zierath, J. R.

10.1101/2021.02.24.432683 — physiology — Posted on 2021-02-25

504 Examining the quality and fertilization competence of bovine ejaculate with low progressive motility, should we give it a chance?

Li, Y.; Kalo, D.; Elbaz, A. K.; Zeron, Y.; Roth, Z.

10.1101/2021.02.24.432701 — physiology — Posted on 2021-02-25

505 Structural and Functional Diversity among Agonist-Bound States of the GLP-1 Receptor

Cary, B. P.; Zhao, P.; Truong, T. T.; Piper, S. J.; Belousoff, M. J.; Danev, R.; Sexton, P. M.; Wootten, D.; Gellman, S. H.

10.1101/2021.02.24.432589 — pharmacology and toxicology — Posted on 2021-02-25

506 Single-cell transcriptomics reveal cell type-specific molecular changes and altered intercellular communications in chronic obstructive pulmonary disease

Huang, Q.; Wang, J.; Shen, S.; Wang, Y.; Chen, Y.; Wu, S.; Xu, W.; Chen, B.; Lin, M.; Wu, J.

10.1101/2021.02.23.432590 — pathology — Posted on 2021-02-25

507 Free Energy Landscape of RNA Binding Dynamics in Start Codon Recognition by Eukaryotic Ribosomal Pre-Initiation Complex

Kameda, T.; Asano, K.; Togashi, Y.

10.1101/2021.02.24.432637 — biophysics — Posted on 2021-02-25

508 Nanomechanics of negatively supercoiled diaminopurine-substituted DNA

Salerno, D.; Mantegazza, F.; Cassina, V.; Cristofalo, M.; Shao, Q.; Finzi, L.; Dunlap, D.

10.1101/2021.02.24.432629 — biophysics — Posted on 2021-02-25

509 Quantitative analysis of neuronal mitochondrial movement reveals patterns resulting from neurotoxicity of rotenone and 6-hydroxydopamine

Simoes, R. F.; Pino, R.; Moreira-Soares, M.; Kovarova, J.; Neuzil, J.; Travasso, R.; Oliveira, P. J.; Cunha-Oliveira, T.; Pereira, F. B.

10.1101/2021.02.24.432715 — bioinformatics — Posted on 2021-02-25

510 Truly Privacy-Preserving Federated Analytics for Precision Medicine with Multiparty Homomorphic Encryption

Froelicher, D.; Troncoso-pastoriza, J. R.; Raisaro, J. L.; Cuendet, M.; Sa Sousa, J.; Fellay, J.; Hubaux, J.-P.

10.1101/2021.02.24.432489 — bioinformatics — Posted on 2021-02-25

511 Automated strain separation in low-complexity metagenomes using long reads

Vicedomini, R.; Quince, C.; Darling, A. E.; Chikhi, R.

10.1101/2021.02.24.429166 — bioinformatics — Posted on 2021-02-25

512 qc3C: reference-free quality control for Hi-C sequencing data

DeMaere, M. Z.; Darling, A. E.

10.1101/2021.02.24.432586 — bioinformatics — Posted on 2021-02-25

513 Operational and biochemical aspects of co-digestion (co-AD) from sugarcane vinasse, filter cake and deacetylation liquor

Volpi, M. P. C.; Ferraz, A. D.; Franco, T. T.; Moraes, B.

10.1101/2021.02.24.432031 — bioengineering — Posted on 2021-02-25

514 A 48-Channel Receive Array Coil for Mesoscopic Diffusion-Weighted MRI of Human ex vivo Brain Imaging on the 3T Connectome Scanner

Scholz, A.; Etzel, R.; May, M. W.; Mahmutovic, M.; Tian, Q.; Ramos-Llorden, G.; Bilgic, B.; Witzel, T.; Stockmann, J. P.; Mekkaoui, C.; Wald, L. L.; Huang, S. Y.; Yendiki, A.; Keil, B.

10.1101/2021.02.24.432713 — bioengineering — Posted on 2021-02-25

515 Differences in gait stability, trunk and foot accelerations between healthy young and older women

Zhang, Y.; Zhou, X.; Pijnappels, M.; Bruijn, S. M.

10.1101/2021.02.24.432667 — bioengineering — Posted on 2021-02-25

516 Permeant Fluorescent Probes Visualize the Activation of SARM1 and Uncover an Anti-neurodegenerative Drug Candidate

Li, W. H.; Huang, K.; Cai, Y.; Wang, Q. W.; Zhu, W. J.; Hou, Y. N.; Wang, S.; Cao, S.; Zhao, Z. Y.; Xie, X. J.; Du, Y.; Lee, C.; Lee, H. C.; Zhang, H.; Zhao, Y. J.

10.1101/2021.02.24.432704 — biochemistry — Posted on 2021-02-25

517 Replicating Light-Off Startle Responses in Drosophila melanogaster

Allen, T. A.; Budenberg, W. J.

10.1101/2021.02.24.432669 — animal behavior and cognition — Posted on 2021-02-25

518 Perception of biological motion in point-light displays by jumping spiders

De Agrò, M.; Roessler, D. C.; Kim, K.; Shamble, P. S.

10.1101/2021.02.24.432515 — animal behavior and cognition — Posted on 2021-02-25

519 Sense of absence: Spatial perception through active sensing by insect antennal mechanosensory system

Ifere, N. O.; Shidara, H.; Sato, N.; Ogawa, H.

10.1101/2021.02.23.432611 — animal behavior and cognition — Posted on 2021-02-25

520 Projecting ancient ancestry in modern-day Arabians and Iranians: a key role of the past exposed Arabo-Persian Gulf on human migrations

Ferreira, J. C.; Alshamali, F.; Montinaro, F.; Cavadas, B.; Torroni, A.; Pereira, L.; Raveane, A.; Fernandes, V.

10.1101/2021.02.24.432678 — genetics — Posted on 2021-02-25

521 Approximate Bayesian computation untangles signatures of contemporary and historical hybridization between two endangered species

Dittberner, H.; Tellier, A.; de Meaux, J.

10.1101/2021.02.24.432626 — evolutionary biology — Posted on 2021-02-25

522 Population monitoring of snow leopards using camera trapping in Naryn State Reserve, Kyrgyzstan, between 2016 and 2019

Rode, J.; Lambert, C.; Marescot, L.; Chaix, B.; Beesau, J.; Bastian, S.; Cabanat, A.-L.

10.1101/2021.02.24.432722 — ecology — Posted on 2021-02-25

523 Condensation of the Drosophila Nerve Cord is Oscillatory and depends on Coordinated Mechanical Interactions

Karkali, K.; Tiwari, P.; Singh, A.; Tlili, S.; Jorba, I.; Navajas, D.; Munoz Romero, J. J.; Saunders, T. E.; Martin-Blanco, E.

10.1101/2021.02.24.432750 — developmental biology — Posted on 2021-02-24

524 Biased removal and loading of centromeric histone H3 during reproduction underlies uniparental genome elimination

Marimuthu, M. P. A.; Maruthachalam, R.; Bondada, R.; Kuppu, S.; Tan, E.-H.; Britt, A.; Chan, S. S. W.; Comai, L.

10.1101/2021.02.24.432754 — cell biology — Posted on 2021-02-24

525 Dichotomous regulation of lysosomes by MYC and TFEB controls hematopoietic stem cell fate

Garcia-Prat, L.; Kaufmann, K. B.; Schneiter, F.; Voisin, V.; Murison, A.; Chen, J.; Chan-Seng-Yue, M.; Gan, O. I.; McLeod, J. L.; Smith, S. A.; Shoong, M. C.; Parris, D.; Pan, K.; Zeng, A. G. X.; Krivdova, G.; Gupta, K.; Takayanagi, S.-I.; Wagenblast, E.; Wang, W.; Lupien, M.; Schroeder, T.; Xie, S. Z.; Dick, J. E.

10.1101/2021.02.24.432720 — cell biology — Posted on 2021-02-24

526 The stress-sensing domain of activated IRE1α forms helical filaments in narrow ER membrane tubes

Carter, S. D.; Tran, N.-H.; De Maziere, A.; Ashkenazi, A.; Klumperman, J.; Jensen, G. J.; Walter, P.

10.1101/2021.02.24.432779 — cell biology — Posted on 2021-02-24

527 Mitochondrial and metabolic remodeling in human skin fibroblasts in response to glucose availability

Costa, C. F.; Pinho, S. A.; Pinho, S. L. C.; Miranda-Santos, I.; Bagshaw, O.; Stuart, J.; Oliveira, P. J.; Cunha-Oliveira, T.

10.1101/2021.02.24.432508 — cell biology — Posted on 2021-02-24

528 Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transport of macromolecules

Fragasso, A.; Franceschi, N. D.; Stoemmer, P.; Van der Sluis, E. O.; Dietz, H.; Dekker, C.

10.1101/2021.02.24.432733 — biophysics — Posted on 2021-02-24

529 Morningness-eveningness assessment from mobile phone communication analysis

Roy, C.; Monsivais, D.; Bhattacharya, K.; Dunbar, R. I. M.; Kaski, K.

10.1101/2021.02.24.432651 — evolutionary biology — Posted on 2021-02-24

530 Dynamics of anteroposterior axis establishment in a mammalian embryo-like system

Anlas, K.; Gritti, N.; Oriola, D.; Arato, K.; Nakaki, F.; Lim, J. L.; Sharpe, J.; Trivedi, V.

10.1101/2021.02.24.432766 — developmental biology — Posted on 2021-02-24

531 Circadian rhythm shows potential for mRNA efficiency and self-organized division of labor in multinucleate cells

Zinn-Brooks, L.; Roper, M.

10.1101/2021.02.24.432653 — cell biology — Posted on 2021-02-24

532 Mammalian adipogenesis regulators (Aregs) exhibit robust non- and anti-adipogenic properties that arise with age and involve retinoic acid signalling

Zachara, M.; Rainer, P. Y.; Russeil, J.; Hashimi, H.; Alpern, D.; Ferrero, R.; Litovchenko, M.; Deplancke, B.

10.1101/2021.02.24.432431 — cell biology — Posted on 2021-02-24

533 Longitudinal high-resolution imaging through a flexible intravital imaging window

Jacquemin, G.; Benavente-Diaz, M.; Djaber, S.; Bore, A.; Dangles-Marie, V.; Surdez, D.; Tajbakhsh, S.; Fre, S.; Lloyd-Lewis, B.

10.1101/2021.02.24.432491 — cell biology — Posted on 2021-02-24

534 Cerebellar Dentate Connectivity Across Adulthood: A Large-Scale Resting State Functional Connectivity Investigation

Bernard, J. A.; Ballard, H.; Jacksons, T. B.

10.1101/2021.02.24.432761 — neuroscience — Posted on 2021-02-24

535 Selection of active defensive behaviors relies on extended amygdala dopamine D2 receptors

Castell, L.; Le Gall, V.; Cutando, L.; Puighermanal, E.; Jercog, D.; Tarot, P.; Tassou, A.; Harrus, A.-G.; Rubinstein, M.; Nouvian, R. M.; Rivat, C.; Herry, C.; Valjent, E.

10.1101/2021.02.24.432692 — neuroscience — Posted on 2021-02-24

536 Evaluating the reliability of human brain white matter tractometry

Kruper, J.; Yeatman, J. D.; Richie-Halford, A.; Bloom, D.; Grotheer, M.; Caffarra, S.; Kiar, G.; Karipidis, I. I.; Roy, E.; Rokem, A.

10.1101/2021.02.24.432740 — neuroscience — Posted on 2021-02-24

537 Characterization of late structural maturation with a neuroanatomical marker that considers both cortical thickness and intracortical myelination

Maingault, S.; Pepe, A.; Mazoyer, B.; Tzourio-Mazoyer, N.; Crivello, F.

10.1101/2021.02.24.432645 — neuroscience — Posted on 2021-02-24

538 Could Italy host the new coronavirus before China?

Tichopad, A.; Pecen, L.

10.1101/2021.02.24.432649 — scientific communication and education — Posted on 2021-02-24

539 Effects of substrate stiffness and actin velocity on fibronectin fibril morphometry and mechanics

Weinberg, S. H.; Saini, N.; Lemmon, C.

10.1101/2021.02.24.432650 — biophysics — Posted on 2021-02-24

540 Chitosan-olive oil microparticles for phenylethyl isothiocyanate delivery: optimal formulation

Coscueta, E. R.; Sousa, A. S.; Reis, C. A.; Pintado, M. M.

10.1101/2021.02.24.432652 — bioengineering — Posted on 2021-02-24

541 A systematic approach for finding herbicide synergies

Sukhoverkov, K. V.; Mylne, J. S.

10.1101/2021.02.08.430187 — plant biology — Posted on 2021-02-24

542 Frequency of quorum sensing mutations in Pseudomonas aeruginosa strains isolated from different environments

O'Connor, K.; Zhao, C. Y.; Diggle, S. P.

10.1101/2021.02.22.432365 — microbiology — Posted on 2021-02-24

543 Microbial colonization induces histone acetylation critical for inherited gut-germline-neural signaling

Hong, C.; Lalsiamthara, J.; Ren, J.; Sang, Y.; Aballay, A.

10.1101/2020.09.10.291823 — immunology — Posted on 2021-02-24

544 Comparing spatial null models for brain maps

Markello, R.; Misic, B.

10.1101/2020.08.13.249797 — neuroscience — Posted on 2021-02-24

545 REMY: A platform for the rapid interrogation of epigenome modifications on yeast

Waldman, A. C.; Rao, B. M.; Keung, A. J.

10.1101/2021.02.24.432679 — synthetic biology — Posted on 2021-02-24

546 Functional Near Infrared Spectroscopy (fNIRS) based Odor Detection and Classification using Functional Data Analysis

Moradi, F.; Moein, S. T.; Zakeri, I.; Pourrezaei, K.

10.1101/2021.02.13.431051 — bioinformatics — Posted on 2021-02-24

547 Transport Dynamics of MtrD: an RND multidrug efflux pump from Neisseria gonorrhoeae

Ammerman, L.; Mertz, S. B.; Park, C.; Wise, J. G.

10.1101/2021.02.24.432727 — biochemistry — Posted on 2021-02-24

548 Glypiated FGF directs contact-mediated bidirectional signaling to self-regulate tissue-specific dispersion

Du, L.; Sohr, A.; Roy, S.

10.1101/2021.02.23.432493 — developmental biology — Posted on 2021-02-24

549 Spontaneous Facet Joint Osteoarthritis in NFAT1-Mutant Mice

Wang, J.; Lu, Q.; Mackay, M. J.; Liu, X.; Burton, D. C.; Asher, M. A.

10.1101/2021.02.23.432595 — molecular biology — Posted on 2021-02-24

550 Implications of central carbon metabolism in SARS-CoV-2 replication and disease severity

Krishnan, S.; Nordqvist, H.; Ambikan, A. T.; Gupta, S.; Sperk, M.; Svensson-Akusjarvi, S.; Mikaeloff, F.; Benfeitas, R.; Saccon, E.; Ponnan, S. M.; Rodriguez, J. E.; Nikouyan, N.; Odeh, A.; Ahlen, G.; Asghar, M.; Sallberg, M.; Vesterbacka, J.; Nowak, P.; Vegvari, A.; Sonnerborg, A.; Treutiger, C. J.; Neogi, U.

10.1101/2021.02.24.432759 — microbiology — Posted on 2021-02-24

551 Reciprocal repulsions instruct the precise assembly ofparallel hippocampal networks

Pederick, D. T.; Lui, J. H.; Gingrich, E. C.; Xu, C.; Wagner, M. J.; Liu, Y.; He, Z.; Quake, S. R.; Luo, L.

10.1101/2020.05.28.122242 — neuroscience — Posted on 2021-02-24

552 Identification of neural oscillations and epileptiform changes in human brain organoids

Samarasinghe, R. A.; Miranda, O. A.; Buth, J. E.; Mitchell, S.; Ferando, I.; Watanabe, M.; Allison, T. F.; Kurdian, A.; Fotion, N. N.; Gandal, M. J.; Golshani, P.; Plath, K.; Lowry, W. E.; Parent, J. M.; Mody, I.; Novitch, B. G.

10.1101/820183 — neuroscience — Posted on 2021-02-24

553 No impact of functional connectivity of the motor system on the resting motor threshold: A replication study.

Engelhardt, M. J.; Komnenic, D.; Roth, F.; Kawelke, L.; Finke, C.; Picht, T.

10.1101/2020.10.26.354886 — neuroscience — Posted on 2021-02-24

554 Bacteriophage self-counting in the presence of viral replication

Coleman, S.; Yao, T.; Nguyen, T. V. P.; Golding, I.; Igoshin, O. A.

10.1101/2021.02.24.432718 — systems biology — Posted on 2021-02-24

555 Characterisation of growth plate dynamics in murine models of osteoarthritis

Samvelyan, H. J.; Madi, K.; Tornqvist, A. E.; Javaheri, B.; Staines, K. A.

10.1101/2020.10.14.339119 — physiology — Posted on 2021-02-24

556 Agonist efficiency from concentration-response curves: structural implications and applications

Indurthi, D.; Auerbach, A.

10.1101/2020.10.13.337410 — biophysics — Posted on 2021-02-24

557 Inference of high-resolution trajectories in single cell RNA-Seq data from RNA velocity

Zhang, Z.; Zhang, X.

10.1101/2020.09.30.321125 — bioinformatics — Posted on 2021-02-24

558 Normalizing and denoising protein expression data from droplet-based single cell profiling

Mulè, M. P.; Martins, A. J.; Tsang, J. S.

10.1101/2020.02.24.963603 — bioinformatics — Posted on 2021-02-24

559 Molecular evolutionary dynamics of energy limited microorganisms

Shoemaker, W. R.; Polezhaeva, E.; Givens, K. B.; Lennon, J. T.

10.1101/2021.02.08.430186 — evolutionary biology — Posted on 2021-02-24

560 A functional genetic toolbox for human tissue-derived organoids

Sun, D.; Evans, L. D.; Lim, K.; Rawlins, E. L.

10.1101/2020.05.04.076067 — developmental biology — Posted on 2021-02-24

561 SARS-CoV-2 ORF6 disturbs nucleocytoplasmic trafficking to advance the viral replication

Miyamoto, Y.; Itoh, Y.; Suzuki, T.; Tanaka, T.; Sakai, Y.; Koido, M.; Hata, C.; Wan, C.-X.; Otani, M.; Moriishi, K.; Tachibana, T.; Kamatani, Y.; Yoneda, Y.; Okamoto, T.; Oka, M.

10.1101/2021.02.24.432656 — microbiology — Posted on 2021-02-24

562 Study Of Biofilm Formation by Pseudomonas aureginosa in two different catheters

Asante, E.

10.1101/2021.02.23.432614 — microbiology — Posted on 2021-02-24

563 Synergistic Activity of Minocycline and Rifampin in Combination with Antifungal Drugs against Candida auris

Brennan-Krohn, T.; Friar, L.; Ditelberg, S.; Kirby, J. E.

10.1101/2021.02.23.432620 — microbiology — Posted on 2021-02-24

564 Influenza virus ribonucleoprotein complex formation occurs in the nucleolus

Miyamoto, S.; Nakano, M.; Morikawa, T.; Hirabayashi, A.; Tamura, R.; Fujita, Y.; Hirose, N.; Muramoto, Y.; Noda, T.

10.1101/2021.02.24.432647 — microbiology — Posted on 2021-02-24

565 A randomization-based causal inference framework for uncovering environmental exposure effects on human gut microbiota

Sommer, A. J.; Peters, A.; Cyrys, J.; Grallert, H.; Haller, D.; Müller, C. L.; Bind, M.-A. C.

10.1101/2021.02.24.432662 — microbiology — Posted on 2021-02-24

566 Development of Tribo-Electroceutical Fabrics for Potential Application in Self-sanitizing Personal Protective Equipment (PPE)

Bayan, S.; Adhikari, A.; Pal, U.; Ghosh, R.; Mondal, S.; Darbar, S.; Saha-Dasgupta, T.; Ray, S. K.; Pal, S. K.

10.1101/2021.02.23.432624 — microbiology — Posted on 2021-02-24

567 Sex-specific glycosylation of secreted immunomodulatory proteins in the filarial nematode Brugia malayi

Koussa, J.; Vitrinel, B.; Whitney, P. H.; Kasper, B.; Mahal, L. K.; Vogel, C.; Lustigman, S.; Salehi-Ashtiani, K.; Ghedin, E.

10.1101/2021.02.24.432741 — microbiology — Posted on 2021-02-24

568 Csf1r-GCaMP5 Reporter Mice Reveal Immune Cell Communication in Vitro and in Vivo

Taghdiri, N.; Calcagno, D. M.; Fu, Z. R.; Huang, K.; Kohler, R. H.; Weissleder, R.; Coleman, T. P.; King, K. R.

10.1101/2021.02.24.432710 — immunology — Posted on 2021-02-24

569 Cytotoxic lymphocytes target HIV-1 Gag through granzyme M-mediated cleavage

Saccon, E.; Mikaeloff, F.; Figueras Ivern, P.; Vegvari, A.; Sonnerborg, A.; Neogi, U.; van Domselaar, R.

10.1101/2021.02.24.432686 — immunology — Posted on 2021-02-24

570 An ultrasensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo

Wu, Z.; He, K.; Chen, Y.; Li, H.; Pan, S.; Li, B.; Liu, T.; Wang, H.; Du, J.; Jing, M.; Li, Y.

10.1101/2021.02.24.432680 — neuroscience — Posted on 2021-02-24

571 Eye-Region Specific Ribbon Tuning Supports Distinct Modes of Synaptic Transmission in Same-Type Cone-Photoreceptors

Schroeder, C.; Oesterle, J.; Berens, P.; Yoshimatsu, T.; Baden, T.

10.1101/2021.02.24.432674 — neuroscience — Posted on 2021-02-24

572 Data-driven filtration and segmentation of mesoscale neural dynamics

Weiser, S. C.; Mullen, B. R.; Ascencio, D.; Ackman, J. B.

10.1101/2020.12.30.424865 — neuroscience — Posted on 2021-02-24

573 Determinants of ligand-functionalized DNA nanostructure-cell interactions

Cremers, G. A. O.; Rosier, B. J. H. M.; Meijs, A.; Tito, N. B.; van Duijnhoven, S. M. J.; van Eenennaam, H.; Albertazzi, L.; de Greef, T. F. A.

10.1101/2021.02.24.432702 — synthetic biology — Posted on 2021-02-24

574 Discovery of a AhR flavonoid agonist that counter-regulates ACE2 expression in rodent models of inflammation and attenuates ACE2-SARS-CoV2 interaction in vitro

Biagioli, M.; Marchiano, S.; Roselli, R.; Di Giorgio, C.; Bellini, R.; Bordoni, M.; Gidari, A.; Sabbatini, S.; Francisci, D.; Fiorillo, B.; Catalanotti, B.; Distrutti, E.; Carino, A.; Zampella, A.; Costantino, G.; Fiorucci, S.

10.1101/2021.02.24.432203 — pharmacology and toxicology — Posted on 2021-02-24

575 The deacylase SIRT5 supports melanoma viability by regulating chromatin dynamics

Giblin, W.; Bringman-Rodenbarger, L.; Guo, A. H.; Kumar, S.; Monovich, A. C.; Mostafa, A. M.; Skinner, M. E.; Azar, M.; Mady, A. S. A.; Chung, C. H.; Kadambi, N.; Melong, K.-A.; Lee, H.-J.; Zhang, L.; Sajjakulnukit, P.; Trefely, S.; Varner, E. L.; Iyer, S.; Wang, M.; Wilmott, J. S.; Soyer, H. P.; Sturm, R. A.; Pritchard, A. L.; Andea, A.; Scolyer, R. A.; Stark, M. S.; Scott, D. A.; Fullen, D. R.; Bosenberg, M. W.; Chandrasekaran, S.; Nikolovska-Coleska, Z.; Verhaegen, M. E.; Snyder, N. W.; Rivera, M. N.; Osterman, A. L.; Lyssiotis, C. A.; Lombard, D. B.

10.1101/2020.09.07.286526 — cancer biology — Posted on 2021-02-24

576 Light-powered reactivation of flagella and contraction of microtubules network: towards building an artificial cell

Ahmad, R.; Kleineberg, C.; Nasirimarekani, V.; Su, Y. J.; Goli Pozveh, S.; Bae, A. J.; Bodenschatz, E.; Sundmacher, K.; Guido, I.; Vidakovich-Koch, T.; Gholami, A.

10.1101/2020.07.20.212191 — biophysics — Posted on 2021-02-24

577 Informing NMR experiments with molecular dynamics simulations to characterize the dominant activated state of the KcsA ion channel

Perez-Conesa, S.; Keeler, E. G.; Zhang, D.; Delemotte, L.; McDermott, A. E.

10.1101/2020.12.14.422800 — biophysics — Posted on 2021-02-24

578 AMPGAN v2: Machine Learning Guided Discovery of Anti-Microbial Peptides

Van Oort, C. M.; Ferrell, J. B.; Remington, J. M.; Wshah, S.; Li, J.

10.1101/2020.11.18.388843 — biophysics — Posted on 2021-02-24

579 A missense variant effect prediction and annotation resource for SARS-CoV-2

Dunham, A.; Jang, G. M.; Muralidharan, M.; Swaney, D.; Beltrao, P.

10.1101/2021.02.24.432721 — bioinformatics — Posted on 2021-02-24

580 Cryo-EM study on the homo-oligomeric ring formation of yeast TRiC/CCT subunits reveals TRiC ring assembly mechanism

Cong, Y.; Liu, C.; Wang, H.; Jin, M.; Han, W.; Wang, S.; Wang, Y.; Wang, F.; Su, C.; Hong, X.; Zhao, Q.

10.1101/2021.02.24.432666 — biochemistry — Posted on 2021-02-24

581 Innate behavior sequence progression by peptide-mediated interorgan crosstalk

Heredia, F.; Volonte, Y.; Pereirinha, J.; Fernandez-Acosta, M.; Casimiro, A. P.; Belem, C. G.; Viegas, F.; Tanaka, K.; Menezes, J.; Arana, M.; Cardoso, G. A.; Macedo, A.; Kotowicz, M.; Prado Spalm, F. H.; Dibo, M.; Monfardini, R. D.; Torres, T. T.; Mendes, C. S.; Garelli, A.; Gontijo, A. M.

10.1101/2020.10.10.334540 — animal behavior and cognition — Posted on 2021-02-24

582 Nuclear Hormone Receptor NHR-49 controls a HIF-1-independent hypoxia adaptation pathway in Caenorhabditis elegans

Doering, K. R. S.; Cheng, X.; Milburn, L.; Ratnappan, R.; Ghazi, A.; Miller, D. L.; Taubert, S.

10.1101/2021.02.24.432575 — genetics — Posted on 2021-02-24

583 Modeling host-associating microbes under selection

Bansept, F.; Obeng, N.; Schulenburg, H.; Traulsen, A.

10.1101/2021.02.24.432736 — evolutionary biology — Posted on 2021-02-24

584 Pervasive effects of Wolbachia on host activity

Hague, M. T. J.; Woods, H. A.; Cooper, B. S.

10.1101/2021.02.24.432688 — evolutionary biology — Posted on 2021-02-24

585 Single particle-resolution fluorescence microscopy of nanoplastics

Nguyen, B.; Tufenkji, N.

10.1101/2020.08.25.267443 — ecology — Posted on 2021-02-24

586 Single cell trajectory analysis of human pluripotent stem cells differentiating towards lung and hepatocyte progenitors

Ori, C.; Ansari, M.; Angelidis, I.; Theis, F. J.; Schiller, H. B.; Drukker, M.

10.1101/2021.02.23.432413 — developmental biology — Posted on 2021-02-24

587 Cyclophilin A regulates protein phase separation and mitigates haematopoietic stem cell aging

Maneix, L.; Iakova, P.; Moree, S. E.; King, J. C. K.; Sykes, D. B.; Hill, C. T.; Saez, B.; Spooner, E.; Krause, D. S.; Sahin, E.; Berk, B. C.; Scadden, D. T.; Catic, A.

10.1101/2021.02.24.432737 — cell biology — Posted on 2021-02-24

588 Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis.

Gopalan, J.; Omar, M.; Roy, A.; Cruz, N. M.; Falcone, J.; Forbush, K.; Himmelfarb, J.; Freedman, B.; Scott, J. D.

10.1101/2021.02.24.432764 — cell biology — Posted on 2021-02-24

589 ADF and cofilin-1 collaborate to promote cortical actin flow and the leader bleb-based migration of confined cells

Ullo, M. F.; Logue, J. S.

10.1101/2021.01.11.426289 — cell biology — Posted on 2021-02-24

590 RNase R, a new virulence determinant of Streptococcus pneumoniae

Barria, C.; Mil-Homens, D.; Fialho, A. M.; Arraiano, C. M.; Domingues, S.

10.1101/2021.02.24.432507 — molecular biology — Posted on 2021-02-24

591 A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targets

Kratzel, A.; Kelly, J. N.; Brueggemann, Y.; Portmann, J.; V'kovski, P.; Todt, D.; Ebert, N.; Steinmann, E.; Dijkman, R.; Zimmer, G.; Pfaender, S.; Thiel, V.

10.1101/2021.02.24.432634 — microbiology — Posted on 2021-02-24

592 Targeted Drug Repurposing Against the SARS-CoV-2 E Channel Identifies Blockers With in vitro Antiviral Activity

Tomar, P. P. S.; Krugliak, M.; Arkin, I. T.

10.1101/2021.02.24.432490 — microbiology — Posted on 2021-02-24

593 The nonstructural protein 5 of coronaviruses antagonizes GSDMD-mediated pyroptosis by cleaving and inactivating its pore-forming p30 fragment

Shi, F.; Lv, Q.; Wang, T.; Xu, J.; Xu, W.; Shi, Y.; Fu, X.; Yang, T.; Yang, Y.; Zhuang, L.; Fang, W.; Gu, J.; Li, X.

10.1101/2021.02.23.432418 — microbiology — Posted on 2021-02-24

594 Increased transmission of SARS-CoV-2 lineage B.1.1.7 (VOC 2020212/01) is not accounted for by a replicative advantage in primary airway cells or antibody escape

Brown, J. C.; Goldhill, D. H.; Zhou, J.; Peacock, T. P.; Frise, R.; Goonawardane, N.; Baillon, L.; Kugathasan, R.; Pinto, A.; McKay, P. F.; Hassard, J.; Moshe, M.; Singanayagam, A.; Burgoyne, T.; PHE Virology Consortium, ; Barclay, W. S.

10.1101/2021.02.24.432576 — microbiology — Posted on 2021-02-24

595 Fiber-associated Lachnospiraceae reduce colon tumorigenesis by modulation of the tumor-immune microenvironment

10.1101/2021.02.24.432654 — microbiology — Posted on 2021-02-24

596 Comparative biofilm assays using Enterococcus faecalis OG1RF identify new determinants of biofilm formation

Willett, J. L. E.; Dale, J. L.; Kwiatkowski, L. M.; Powers, J. L.; Korir, M. L.; Kohli, R.; Barnes, A. M. T.; Dunny, G. M.

10.1101/2021.02.24.432758 — microbiology — Posted on 2021-02-24

597 Cleavage of Braun lipoprotein Lpp from the bacterial peptidoglycan by a paralog of L,D-transpeptidases, LdtF

Bahadur, R.; Chodisetti, P. K.; Reddy, M.

10.1101/2021.02.24.432682 — microbiology — Posted on 2021-02-24

598 Identification of host antiviral genes differentially induced by clinically diverse strains of Tick-Borne Encephalitis Virus

Jones, I. M.; Goonawardane, N.; Laura, U.; Harris, M.

10.1101/2021.02.23.432617 — microbiology — Posted on 2021-02-24

599 cpn60 barcode sequences accurately identify newly defined genera within the Lactobacillaceae

Shukla, I.; Hill, J. E.

10.1101/2021.02.24.432354 — microbiology — Posted on 2021-02-24

600 Genetic determinants of intrinsic antibiotic tolerance in Mycobacterium avium

Matern, W. M.; Parker, H.; Danchik, C.; Hoover, L.; Bader, J.; Karakousis, P. C.

10.1101/2021.02.23.432616 — microbiology — Posted on 2021-02-24

601 Targeting of the NLRP3 Inflammasome for early COVID-19

Marchetti, C.; Mould, K.; Tengesdal, I. W.; Janssen, W. J.; Dinarello, C. A.

10.1101/2021.02.24.432734 — immunology — Posted on 2021-02-24

602 Dysregulation of the secretory pathway connects Alzheimer's disease genetics to aggregate formation

Kuo, C.-C.; Chiang, W.-T.; Baghdassarian, H. M.; Lewis, N. E.

10.1101/2020.08.10.243634 — neuroscience — Posted on 2021-02-24

603 Rapid adaptation and remote delivery of undergraduate research training during the COVID 19 Pandemic

Yang Yowler, J.; Knier, K.; WareJoncas, Z.; Ehlers, S. L.; Ekker, S. C.; Guasp Reyes, F.; Horazdovsky, B. F.; Mueller, G.; Morales Gomez, A.; Sood, A.; Sussman, C. R.; Scholl, L. M.; Weavers, K. M.; Pierret, C.

10.1101/2021.02.24.432694 — scientific communication and education — Posted on 2021-02-24

604 Quasi-species evolution maximizes genotypic reproductive value (not fitness or flatness)

Smerlak, M.

10.1101/2021.02.23.432496 — evolutionary biology — Posted on 2021-02-24

605 BMSS2: a unified database-driven modelling tool for systematic model selection and identifiability analysis

Ngo, R. K. J.; Yeoh, J. W.; Fan, G. H. W.; Loh, W. K. S.; Poh, C. L.

10.1101/2021.02.23.432592 — synthetic biology — Posted on 2021-02-24

606 Acute and chronic effects of exams week on cortisol production in undergraduate students

Borghi, F.; da Silva, P. C.; Canova, F.; Souza, A. L.; Barbedo Arouca, A.; Grassi-Kassisse, D. M.

10.1101/2021.02.23.432585 — physiology — Posted on 2021-02-24

607 Regression QSAR Models for Predicting HIV-1 Integrase Inhibitors

Ha, C. H. X.; Lee, N. K.; Rahman, T.; Hwang, S. S.; Yam, W. K.; Chee, X. W.

10.1101/2021.02.23.432583 — pharmacology and toxicology — Posted on 2021-02-24

608 Cortical Tension Initiates the Positive Feedback Loop Between E-cadherin and F-actin

Yu, Q.; Holmes, W. R.; Thiery, J. P.; Luwor, R. B.; Rajagopal, V.

10.1101/2021.02.23.432578 — biophysics — Posted on 2021-02-24

609 Low rank approximation of difference between correlation matrices by using inner product

Tanioka, K.; Hiwa, S.

10.1101/2021.02.23.432533 — bioinformatics — Posted on 2021-02-24

610 The Gossypium stocksii genome as a novel resource for cotton improvement

Grover, C. E.; Yuan, D.; Arick, M. A.; Miller, E. R.; Hu, G.; Peterson, D. G.; Wendel, J. F.; Udall, J. A.

10.1101/2021.02.23.432605 — genomics — Posted on 2021-02-24

611 Chemoenzymatic labeling of DNA methylation patterns for single-molecule epigenetic mapping

Gabrieli, T.; Michaeli, Y.; Avraham, S.; Torchinsky, D.; Juhasz, M.; Coruh, C.; Arbib, N.; Zhou, Z. S.; Law, J. A.; Weinhold, E.; Ebenstein, Y.

10.1101/2021.02.24.432628 — genomics — Posted on 2021-02-24

612 The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid-liquid phase separation

Owen, I.; Yee, D.; Wyne, H.; Perdikari, T. M.; Johnson, V.; Smyth, J.; Kortum, R.; Fawzi, N. L.; Shewmaker, F.

10.1101/2021.02.24.432743 — cell biology — Posted on 2021-02-24

613 Intracellular pools of DAG-activated TRPC3 channels are essential for TLR4 activation

Casas, J.; Meana, C.; Lopez-Lopez, J. R.; Balsinde, J.; Balboa, M. A.

10.1101/2021.02.24.432657 — immunology — Posted on 2021-02-24

614 Small-molecule inhibitors of the RNA m6A demethylase FTO potently support the survival of dopamine neurons

Selberg, S.; Li-Ying, Y.; Bondarenko, O.; Kankuri, E.; Seli, N.; Kovaleva, V.; Herodes, K.; Saarma, M.; Karelson, M.

10.1101/2021.02.23.432419 — neuroscience — Posted on 2021-02-24

615 Cell Communication Network factor 4 promotes tumor-induced immunosuppression in melanoma

Fernandez, A.; Deng, W.; McLaughlin, S. L.; Pirkey, A. C.; Rellick, S.; Klinke, D. J.

10.1101/2021.02.23.432584 — cancer biology — Posted on 2021-02-24

616 Chromatin accessibility changes at intergenic regions associates with ovarian cancer drug resistance

Gallon, J.; Loomis, E.; Curry, E.; Martin, N.; Brody, L.; Garner, I.; Brown, R.; Flanagan, J. M.

10.1101/2021.02.24.432641 — cancer biology — Posted on 2021-02-24

617 p97/VCP induces GLI1 to control XBP1-dependent endoplasmic reticulum stress transcriptional response

Barroso, K.; Almada, L. L.; Olson, R.; Auner, H.; Pedeux, R.; IOVANNA, J. L.; Chevet, E.; Fernandez-Zapico, M. E.

10.1101/2021.02.24.432555 — cancer biology — Posted on 2021-02-24

618 Application of a novel haplotype-based scan for local adaptation to study high-altitude adaptation in rhesus macaques

Szpiech, Z. A.; Novak, T. E.; Bailey, N. P.; Stevison, L. S.

10.1101/2020.05.19.104380 — evolutionary biology — Posted on 2021-02-24

619 MYC promotes immune-suppression in TNBC via inhibition of IFN signaling

Zimmerli, D.; Brambillasca, C. S.; Talens, F.; Bhin, J.; Bhattacharya, A.; Joosten, S. E. P.; Moises da Silva, A.; Wellenstein, M. D.; Kersten, K.; de Boo, M.; Roorda, M.; Henneman, L.; de Bruijn, R.; Annunziato, S.; van der Burg, E.; Drenth, A. P.; Lutz, C.; van der Ven, M.; Wessels, L.; de Visser, K. E.; Zwart, W.; Fehrmann, R. S. N.; van Vugt, M. A. T. M.; Jonkers, J.

10.1101/2021.02.24.432659 — cancer biology — Posted on 2021-02-24

620 Most cancers carry a substantial deleterious load due to Hill-Robertson interference

Tilk, S.; Curtis, C.; Petrov, D.; McFarland, C. D.

10.1101/764340 — evolutionary biology — Posted on 2021-02-24

621 Marine heatwaves depress metabolic activity and impair cellular acid-base homeostasis in reef-building corals regardless of bleaching susceptibility

Innis, T.; Allen-Waller, L.; Brown, K. T.; Sparagon, W.; Carlson, C.; Kruse, E.; Huffmyer, A. S.; Nelson, C. E.; Putnam, H. M.; Barott, K. L.

10.1101/2021.02.23.432550 — ecology — Posted on 2021-02-24

622 Visualizing and quantifying data from timelapse imaging experiments

Mahlandt, E. K.; Goedhart, J.

10.1101/2021.02.24.432684 — cell biology — Posted on 2021-02-24

623 Cerebellar connectivity maps embody individual adaptive behavior

Spaeth, L.; BAHUGUNA, J.; Gagneux, T.; Dorgans, K.; Sugihara, I.; Poulain, B.; Battaglia, D.; Isope, P.

10.1101/2021.02.24.432563 — neuroscience — Posted on 2021-02-24

624 Mental individuation of imagined finger movements can be achieved using TMS-based neurofeedback

Mihelj, E.; Bachinger, M.; Kikkert, S.; Ruddy, K. L.; Wenderoth, N.

10.1101/2021.02.23.432532 — neuroscience — Posted on 2021-02-24

625 Neural correlates of subsequent memory-related gaze reinstatement

Wynn, J. S.; Liu, Z.-X.; Ryan, J. D.

10.1101/2021.02.23.432536 — neuroscience — Posted on 2021-02-24

626 Glia-neuron signaling mediated by two different BMP ligands impacts synaptic growth

Bartoletti, M.; Knight, T.; Held, A.; Rand, L.; Wharton, K. A.

10.1101/2021.02.23.432606 — neuroscience — Posted on 2021-02-24

627 Distrust Before First Sight: Knowledge- and Appearance-Based Effects of Trustworthiness on the Visual Consciousness of Faces

Eiserbeck, A.; Enge, A.; Rabovsky, M.; Abdel Rahman, R.

10.1101/2021.02.24.432562 — neuroscience — Posted on 2021-02-24

628 DeTOKI identifies and characterizes the dynamics of chromatin topologically associating domains in a single cell

Li, X.; Zhang, Z.

10.1101/2021.02.23.432401 — bioinformatics — Posted on 2021-02-24

629 Characterization of the different behaviours exhibited by juvenile grey mullet (Mugil cephalus) under rearing conditions

Jimenez Rivera, J. A.; Boglino, A.; Linares Cordova, J. F.; Duncan, N. J.; Ruiz Gomez, M. d. L.; Rey Planellas, S.; Ibarra Zatarain, Z.

10.1101/2021.02.23.432396 — animal behavior and cognition — Posted on 2021-02-24

630 Chronic Stress Alters Astrocyte Morphology in Mouse Prefrontal Cortex

Codeluppi, S. A.-M.; Chatterjee, D.; Prevot, T. D.; Misquitta, K. A.; Sibille, E.; Banasr, M.

10.1101/2021.02.23.432559 — animal behavior and cognition — Posted on 2021-02-24

631 Emergence of variation between groups through time in fish shoal collective motion

MacGregor, H. E. A.; Ioannou, C. C.

10.1101/2021.02.23.432454 — animal behavior and cognition — Posted on 2021-02-24

632 Combinatorial transcription factor profiles predict mature and functional human islet α and β cells

Shrestha, S.; Saunders, D. C.; Walker, J. T.; Camunas-Soler, J.; Dai, X.-Q.; Haliyur, R.; Aramandla, R.; Poffenberger, G.; Prasad, N.; Bottino, R.; Stein, R.; Cartailler, J.-P.; Parker, S. C. J.; MacDonald, P. E.; Levy, S. E.; Powers, A. C.; Brissova, M.

10.1101/2021.02.23.432522 — genomics — Posted on 2021-02-24

633 Nascent RNA sequencing defines dynamic aryl hydrocarbon receptor signaling responses to wood smoke particles

Gupta, A.; Sasse, S. K.; Sanford, L.; Gruca, M. A.; Dowell, R. D.; Gerber, A. N.

10.1101/2021.02.23.432311 — genomics — Posted on 2021-02-24

634 Genes with Specificity for Expression in the Round Cell Layer of the Growth Plate are Enriched in GWAS of Human Height

Renthal, N. E.; Baronas, J. M.; Nakka, P.; Kronenberg, H. M.; Hirschhorn, J. N.

10.1101/2021.02.24.432568 — genetics — Posted on 2021-02-24

635 Evolutionary priming and transition to the ectomycorrhizal habit in an iconic lineage of mushroom-forming fungi: is preadaptation a requirement?

Looney, B. P.; Miyauchi, S.; Morin, E.; Drula, E.; Courty, P.-E.; Kohler, A. P.; Lindquist, E.; Kuo, A.; LaButti, K.; Pangilinan, J.; Lipzen, A.; Riley, R.; Andreopoulos, W.; He, G.; Johnson, J.; Barry, K. W.; Grigoriev, I. V.; Nagy, L. G.; Hibbett, D.; Henrissat, B.; Matheny, P. B.; Labbe, J.; Martin, F. M.

10.1101/2021.02.23.432530 — evolutionary biology — Posted on 2021-02-24

636 Multiple mechanisms of photoreceptor spectral tuning following loss of UV color vision in Heliconius butterflies

McCulloch, K. J.; Macias-Munoz, A.; Mortazavi, A.; Briscoe, A. D.

10.1101/2021.02.23.432523 — evolutionary biology — Posted on 2021-02-24

637 The developing mouse coronal suture at single-cell resolution

Farmer, D. T.; Mlcochova, H.; Zhou, Y.; Koelling, N.; Wang, G.; Ashley, N.; Maxson, R. E.; Wilkie, A. O.; Crump, J. G.; Twigg, S. R.

10.1101/2021.02.24.432636 — developmental biology — Posted on 2021-02-24

638 MIA3/TANGO1 enables efficient secretion by constraining COPII vesicle budding

McCaughey, J.; Mantell, J. M.; Neal, C. R.; Heesom, K.; Stephens, D. J.

10.1101/2021.02.24.432632 — cell biology — Posted on 2021-02-24

639 Previous estradiol treatment during midlife maintains transcriptional regulation of memory-related proteins by ERα in the hippocampus in a rat model of menopause

Baumgartner, N. E.; Black, K. L.; McQuillen, S. M.; Daniel, J. M.

10.1101/2021.02.23.432513 — neuroscience — Posted on 2021-02-24

640 Widespread ripples synchronize human cortical activity

Dickey, C. W.; Verzhbinsky, I. A.; Jiang, X.; Rosen, B. Q.; Kajfez, S.; Stedelin, B.; Shih, J. J.; Ben-Haim, S.; Raslan, A. M.; Madsen, J. R.; Eskandar, E. N.; Gonzalez-Martinez, J.; Cash, S. S.; Halgren, E.

10.1101/2021.02.23.432582 — neuroscience — Posted on 2021-02-24

641 Altered environmental perception by parental stress and depression vulnerability: impact on mothers and offspring

Alves, R. L.; Portugal, C. C.; Lopes, I. M.; Oliveira, P.; Alves, C. J.; Barbosa, F.; Summavielle, T.; Magalhaes, A.

10.1101/2021.02.23.432580 — neuroscience — Posted on 2021-02-24

642 Deep Brain Stimulation for Parkinson's Disease Induces Spontaneous Cortical Hypersynchrony In Extended Motor and Cognitive Networks

Wang, M. B.; Boring, M. J.; Ward, M. J.; Richardson, M.; Ghuman, A. S.

10.1101/2021.02.23.432542 — neuroscience — Posted on 2021-02-24

643 Astrocyte nanoscale morphology controls Ca2+ signals at tripartite synapses

Denizot, A.; Arizono, M.; Nägerl, V.; Berry, H.; De Schutter, E.

10.1101/2021.02.24.432635 — neuroscience — Posted on 2021-02-24

644 Difference in hoof conformation between shod and barefoot-managed hooves

de Klerk, J. N.

10.1101/2021.02.23.432452 — zoology — Posted on 2021-02-24

645 VAL genes regulate vegetative phase change via miR156-dependent and independent mechanisms

Fouracre, J. P.; He, J.; Chen, V. J.; Sidoli, S.; Poethig, R. S.

10.1101/2021.02.23.432516 — plant biology — Posted on 2021-02-24

646 Control of testes mass by androgen receptor paralogs in a cichlid

Hoadley, A. P.; Fernald, R. D.; Alward, B. A.

10.1101/2021.02.23.432504 — physiology — Posted on 2021-02-24

647 Topography and motion of the acid-sensing ion channel intracellular domains

Couch, T.; Berger, K.; Kneisley, D. L.; McCullock, T. W.; Kammermeier, P. J.; MacLean, D. M.

10.1101/2021.02.23.432526 — physiology — Posted on 2021-02-24

648 The Organelle in the Room: Under-annotated Mitochondrial Reads Bias Coral Microbiome Analysis

Sonett, D.; Brown, T.; Bengtsson-Palme, J.; Padilla-Gamino, J.; Zaneveld, J. R.

10.1101/2021.02.23.431501 — bioinformatics — Posted on 2021-02-24

649 Likelihood-based Tests for Detecting CircadianRhythmicity and Differential Circadian Patterns in Transcriptomic Applications

Ding, H.; Meng, L.; Liu, A. C.; Gumz, M. L.; Bryant, A. J.; Mcclung, C. A.; Tseng, G. C.; Esser, K. A.; Huo, Z.

10.1101/2021.02.23.432538 — bioinformatics — Posted on 2021-02-24

650 PredictProtein - Predicting Protein Structure and Function for 29 Years

Bernhofer, M.; Dallago, C.; Karl, T.; Satagopam, V.; Heinzinger, M.; Littmann, M.; Olenyi, T.; Qiu, J.; Schuetze, K.; Yachdav, G.; Ashkenazy, H.; Ben-Tal, N.; Bromberg, Y.; Goldberg, T.; Kajan, L.; O'Donoghue, S.; Sander, C.; Schafferhans, A.; Schlessinger, A.; Vriend, G.; Mirdita, M.; Gawron, P.; Gu, W.; Jarosz, Y.; Trefois, C.; Steinegger, M.; Schneider, R.; Rost, B.

10.1101/2021.02.23.432527 — bioinformatics — Posted on 2021-02-24

651 CellWalkR: An R Package for integrating single-cell and bulk data to resolve regulatory elements

Przytycki, P. F.; Pollard, K. S.

10.1101/2021.02.23.432593 — bioinformatics — Posted on 2021-02-24

652 Morphological Landscapes from High Content Imaging Identify Optimal Priming Strategies that Enhance MSC Immunosuppression

Andrews, S. H.; Klinker, M. W.; Bauer, S. R.; Marklein, R. A.

10.1101/2021.02.23.432501 — bioengineering — Posted on 2021-02-24

653 Adaptive introgression and standing genetic variation, two facilitators of adaptation to high latitudes in European aspen (Populus tremula L.)

Rendon-Anaya, M.; Wilson, J.; Sveinsson, S.; Fedorkov, A.; Cottrell, J.; Bailey, M. E. S.; Rungis, D.; Lexer, C.; Jansson, S.; Robinson, K. M.; Street, N. R.; Ingvarsson, P. K.

10.1101/2021.02.23.432466 — evolutionary biology — Posted on 2021-02-24

654 Migration Restores Hybrid Incompatibility Driven By Nuclear-Mitochondrial Sexual Conflict

Munasinghe, M.; Haller, B. C.; Clark, A. G.

10.1101/2021.02.23.432505 — evolutionary biology — Posted on 2021-02-24

655 Impacts of agrochemical intensification on the assembly and reassembly of a mainland-island model metacommunity

Pelinson, R. M.; Strecht, B. R.; Shimabukuro, E. M.; Schiesari, L. C.

10.1101/2021.02.23.432475 — ecology — Posted on 2021-02-24

656 A framework for selectively breeding corals for assisted evolution

Humanes, A.; Bythell, J. C.; Beauchamp, E. A.; Carl, M. K.; Craggs, J. R.; Edwards, A. J.; Golbuu, Y.; Lachs, L.; Randle, J. L.; Martinez, H. M.; Palmowski, P.; Paysinger, F.; van der Steeg, E. J.; Sweet, M.; Treumann, A.; Guest, J. R.

10.1101/2021.02.23.432469 — ecology — Posted on 2021-02-24

657 Breeding responses to environmental variation are age- and trait-dependent in female Nazca boobies

Tompkins, E. M.; Anderson, D. J.

10.1101/2021.02.23.432506 — ecology — Posted on 2021-02-24

658 IFNγ and iNOS-mediated alterations in the bone marrow and thymus and its impact on Mycobacterium avium-induced thymic atrophy

Barreira-Silva, P.; Melo-Miranda, R.; Nobrega, C.; Roque, S.; Serre-Miranda, C.; Borges, M.; de Sa Calcada, D.; Behar, S. M.; Appelberg, R.; Correia-Neves, M.

10.1101/2021.02.23.432464 — immunology — Posted on 2021-02-24

659 Expression of recombinant cardosin B in tobacco BY2 cells: an alternative system for the production of active milk clotting enzymes

Folgado, A.; Abranches, R.

10.1101/2021.02.23.432499 — plant biology — Posted on 2021-02-24

660 Extracellular vesicles mediate the intercellular exchange of nanoparticles

Pang, H.; Wu, X.; Tang, T.; Wei, Y.; Cummins, K. A.; Wood, D. K.

10.1101/2021.02.23.432325 — pharmacology and toxicology — Posted on 2021-02-24

661 Estimating DNA methylation potential energy landscapes from nanopore sequencing data

Abante, J.; Kambhampati, S.; Feinberg, A. P.; Goutsias, J.

10.1101/2021.02.22.431480 — bioinformatics — Posted on 2021-02-24

662 TP-MAP - an Integrated Software Package for the Analysis of 1D and 2D Thermal Profiling Data

Feyertag, F.; Huber, K. V. M.

10.1101/2021.02.22.432361 — bioinformatics — Posted on 2021-02-24

663 Predicted distribution of a rare and understudied forest carnivore: Humboldt martens (Martes caurina humboldtensis)

Moriarty, K. M.; Thompson, J.; Delheimer, M. S.; Barry, B. R.; Linnell, M. A.; Levi, T.; Hamm, K.; Early, D.; Gamblin, H.; Szykman Gunther, M.; Ellison, J. L.; Prevey, J.; Hartman, J.; Davis, R.

10.1101/2021.02.05.429381 — ecology — Posted on 2021-02-24

664 Host-associated fungal communities are determined by host phylogeny and exhibit widespread associations with the bacterial microbiome

Harrison, X. A.; McDevitt, A.; Dunn, J. C.; Griffiths, S.; Benvenuto, C.; Birtles, R.; Boubli, J. P.; Bown, K.; Bridson, C.; Brooks, D.; Browett, S. S.; Carden, R. F.; Chantrey, J.; Clever, F.; Coscia, I.; Edwards, K. L.; Ferry, N.; Goodhead, I.; Highlands, A.; Hopper, J.; Jackson, J. A.; Jehle, R.; Kaizer, M.; King, T.; Lea, J. M.; Lenka, J. L.; McCubbin, A.; McKenzie, J.; Moraes, B.; O'Meara, D. B.; Pescod, P.; Preziosi, R. F.; Rowntree, J. K.; Shultz, S.; Silk, M. J.; Stockdale, J. E.; Symondson, W. O.; de la Pena, M.; Walker, S. L.; Wood, M. D.; Antwis, R. E.

10.1101/2020.07.07.177535 — ecology — Posted on 2021-02-24

665 Artemisia annua L. extracts inhibit the in vitro replication of SARS-CoV-2 and two of its variants

Nair, M. S.; Huang, Y.; Fidock, D. A.; Polyak, S. J.; Wagoner, J.; Towler, M.; Weathers, P.

10.1101/2021.01.08.425825 — microbiology — Posted on 2021-02-24

666 Dorsal CA1 Hippocampal Place Cells Form a Multi-Scale Representation of Megaspace

Harland, B.; Contreras, M.; Souder, M.; Fellous, J.-M.

10.1101/2021.02.15.431172 — neuroscience — Posted on 2021-02-24

667 Genetically Engineered Strains for Combinatorial Cardiovascular Optobiology

Lee, F. K.; Lee, J. C.; Shui, B.; Reining, S.; Jibilian, M.; Small, D. M.; Jones, J. S.; Allan-Rahill, N. H.; Lamont, M. R.; Rizzo, M. A.; Tajada, S.; Navedo, M. F.; Santana, L. F.; Nishimura, N.; Kotlikoff, M. I.

10.1101/2021.01.21.427692 — physiology — Posted on 2021-02-24

668 Feeding intervention potentiates the effect of mechanical loading to induce new bone formation in mice

Samvelyan, H. J.; Mathers, J. C.; Skerry, T. M.

10.1101/2020.12.27.424485 — physiology — Posted on 2021-02-24

669 Sensitive, reliable, and robust circRNA detection from RNA-seq with CirComPara2

Gaffo, E.; Buratin, A.; Dal Molin, A.; Bortoluzzi, S.

10.1101/2021.02.18.431705 — bioinformatics — Posted on 2021-02-24

670 Co-translational folding of the first transmembrane domain of ABC-transporter CFTR is supported by assembly with the first cytosolic domain

Kleizen, B.; van Willigen, M.; Mijnders, M.; Peters, F. M.; Grudniewska, M. K.; Hillenaar, T. M.; Thomas, A. S.; Kooijman, L.; Peters, K. W.; Frizzell, R.; van der Sluijs, P.; Braakman, I.

10.1101/2020.12.19.423590 — biochemistry — Posted on 2021-02-24

671 Low-dimensional learned feature spaces quantify individual and group differences in vocal repertoires

Goffinet, J.; Brudner, S.; Mooney, R.; Pearson, J.

10.1101/811661 — animal behavior and cognition — Posted on 2021-02-24

672 A structured observation distribution for generative biological sequence prediction and forecasting

Weinstein, E. N.; Marks, D. S.

10.1101/2020.07.31.231381 — genomics — Posted on 2021-02-24

673 Cross-species Transcriptomic Network Analysis Reveals Links Between Ribosomal Protein Mutation and Cancer

Denton, J. A.; Velasque, M.; Reed, F. A.

10.1101/2020.12.11.420604 — genetics — Posted on 2021-02-24

674 The anatomy of a phenological mismatch: interacting consumer demand and resource characteristics determine the consequences of mismatching

Wilde, L. R.; Simmons, J. E.; Swift, R. J.; Senner, N. R.

10.1101/2020.12.22.423968 — ecology — Posted on 2021-02-24

675 The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

Torrence, M. E.; MacArthur, M. R.; Hosios, A. M.; Valvezan, A.; Asara, J. M.; Mitchell, J. R.; Manning, B. D.

10.1101/2020.10.03.324186 — cell biology — Posted on 2021-02-24

676 A novel DNA-binding protein regulates sexual differentiation in malaria parasites and is essential for transmission.

Campelo Morillo, R.; Tong, X.; Xie, W.; Lenz, T.; Batugedara, G.; Tabassum, N.; Orchard, L. M.; Daher, W.; Patel, D.; Noble, W. S.; Llinas, M.; Le Roch, K. G.; Kafsack, B. F. C.

10.1101/2020.10.26.352583 — microbiology — Posted on 2021-02-24

677 Two opposite voltage-dependent currents control the unusual early development pattern of embryonic Renshaw cell electrical activity

Boeri, J.; Meunier, C.; Le Corronc, H.; Branchereau, P.; Timofeeva, Y.; Lejeune, F.-X.; Mouffle, C.; Arulkandarajah, H.; Mangin, J. M.; Legendre, P.; Czarnecki, A.

10.1101/2020.06.18.158931 — neuroscience — Posted on 2021-02-24

678 Transcranial Random Noise Stimulation acutely lowers the response threshold of human motor circuits

Potok, W.; Baechinger, M.; van der Groen, O.; Cretu, A. L.; Wenderoth, N.

10.1101/2020.10.07.329813 — neuroscience — Posted on 2021-02-24

679 Cortical Responses to the Amplitude Envelopes of Sounds Change with Age

Irsik, V. C.; Almanaseer, A.; Johnsrude, I.; Herrmann, B.

10.1101/2020.10.23.352880 — neuroscience — Posted on 2021-02-24

680 Colloblasts act as a biomechanical sensor for suitable prey in Pleurobrachia

Townsend, J. P.; Merces, G. O.; Castellanos, G. P.; Pickering, M.

10.1101/2020.06.27.175059 — zoology — Posted on 2021-02-24

681 INSULIN-LIKE GROWTH FACTOR I SENSITIZATION REJUVENATES SLEEP PATTERNS IN OLD MICE

Torres Aleman, I.; Zegarra-Valdivia, J. A.; Fernandes, J.; Trueba-Saiz, A.; Fernandez de Sevilla, M. E.; Pignatelli, J.; Suda, K.; Martinez Rachadell, L.; Fernandez, A. M.; Esparza, J.; Vega, M.; Nunez, A.

10.1101/2021.02.23.432494 — neuroscience — Posted on 2021-02-24

682 Scopolamine blocks context-dependent reinstatement of fear responses in rats

Vercammen, L. M.; Lo, A. C.; D'Hooge, R.; Vervliet, B.

10.1101/2021.02.24.432279 — neuroscience — Posted on 2021-02-24

683 Activity-induced gene expression and long-range enhancer-promoter contacts in cohesin-deficient neurons

Calderon, L.; Weiss, F. D.; Beagan, J. A.; Oliveira, M. S.; Wang, Y.-F.; Carroll, T.; Dharmalingam, G.; Gong, W.; Tossell, K.; de Paola, V.; Whilding, C.; Ungless, M. A.; Fisher, A. G.; Phillips-Cremins, J. E.; Merkenschlager, M.

10.1101/2021.02.24.432639 — genomics — Posted on 2021-02-24

684 Apoptotic Extracellular Vesicles (ApoEVs) Safeguard Liver Homeostasis and Regeneration via Assembling an ApoEV-Golgi Organelle

Sui, B.; Wang, R.; Chen, C.; Kou, X.; Wu, D.; Tu, H.-C.; Wang, Y.; Liu, Y.; Jacobson, O.; Chen, X.; Liu, H.; Kwok, R. T. K.; Tang, B. Z.; Yan, H.; Wang, M.; Xiang, L.; Yan, X.; Fu, Y.; Zhang, X.; Tang, J.; Ma, L.; Lu, L.; Jin, Y.; Shi, S.

10.1101/2021.02.24.432630 — cell biology — Posted on 2021-02-24

685 Biogeochemical and omic evidence for paradoxical methane production via multiple co-occurring mechanisms in aquatic ecosystems

Perez-Coronel, E.; Beman, J. M.

10.1101/2020.07.28.225276 — genomics — Posted on 2021-02-24

686 Balancing selection maintains hyper-divergent haplotypes in C. elegans

Lee, D.; Zdraljevic, S.; Stevens, L.; Wang, Y.; Tanny, R. E.; Crombie, T. A.; Cook, D. E.; Webster, A. K.; Chirakar, R.; Baugh, L. R.; Sterken, M.; Braendle, C.; Felix, M.-A.; Rockman, M.; Andersen, E. C.

10.1101/2020.07.23.218420 — evolutionary biology — Posted on 2021-02-24

687 Mapping the probability of forest snowdisturbances in Finland

Suvanto, S.; Lehtonen, A.; Nevalainen, S.; Lehtonen, I.; Viiri, H.; Strandström, M.; Peltoniemi, M.

10.1101/2020.12.23.424139 — ecology — Posted on 2021-02-24

688 Year-round dynamics of amplicon sequence variant communities differ among eukaryotes, Mimiviridae, and prokaryotes in a coastal ecosystem

Prodinger, F.; Endo, H.; Takano, Y.; Li, Y.; Tominaga, K.; Isozaki, T.; Blanc-Mathieu, R.; Gotoh, Y.; Tetsuya, H.; Taniguchi, E.; Nagasaki, K.; Yoshida, T.; Ogata, H.

10.1101/2021.02.02.429489 — microbiology — Posted on 2021-02-24

689 The landscape of PrPC biosynthesis revealed by an arrayed genome-wide interference screen

Heinzer, D.; Avar, M.; Pease, D. P.; Dhingra, A.; Yin, J.-A.; Schaper, E.; Dogancay, B.; Emmenegger, M.; Spinelli, A.; Maggi, K.; Chincisan, A.; Mead, S.; Hornemann, S.; Heutink, P.; Aguzzi, A.

10.1101/2021.01.28.428672 — neuroscience — Posted on 2021-02-24

690 The epoxyeicosatrienoic pathway is intact in endothelial and smooth muscle cells exposed to aldosterone excess

Brunnenkant, L.; Meng, Y.; Sun, J.; Gonzalez Marques, J.; Koletzko, B.; Mederos y Schnitzler, M.; Gudermann, T.; Williams, T. A.; Beuschlein, F.; Heinrich, D. A.; Adolf, C.; Reincke, M.; Schneider, H.

10.1101/2021.02.04.429624 — physiology — Posted on 2021-02-24

691 Calcium Sensitive Allostery Regulates the PI(4,5)P2 Binding Site of the Dysferlin C2A Domain

Otto, S. C.; Reardon, P. N.; Kumar, T. M.; Kuykendall, C. J.; Johnson, C. P.

10.1101/2021.02.10.430549 — biophysics — Posted on 2021-02-24

692 Consumer risk perception towards pesticide stained tomatoes in Uganda.

Sekabojja, D.; Atuhaire, A.; Nabankema, V.; Sekimpi, D.; Jors, E.

10.1101/2021.02.15.431249 — animal behavior and cognition — Posted on 2021-02-24

693 Chromosome-length genome assembly and structural variations of the primal Basenji dog (Canis lupus familiaris) genome

Edwards, R. J.; Field, M. A. J.; Ferguson, J. M.; Dudchenko, O.; Keilwagen, J.; Rosen, B. D.; Johnson, G. S.; Rice, E. S.; Hillier, L.; Hammond, J. M.; Tomwarnicki, S. G.; Omer, A.; Skvortsova, K.; Bogdanovic, O.; Zammit, R. A.; Aiden, E. L.; Warren, W. C.; Ballard, J. W. O.

10.1101/2020.11.11.379073 — genomics — Posted on 2021-02-24

694 Rate-of-change analysis in palaeoecology revisited: a new approach

Mottl, O.; Grytes, J.-A.; Seddon, A. W. R.; Steinbauer, M. J.; Bhatta, K. P.; Felde, V. A.; Flantua, S. G. A.; Birks, H. J. B.

10.1101/2020.12.16.422943 — ecology — Posted on 2021-02-24

695 Recruitment of KRAS downstream target ARL4C to membrane protrusions accelerates pancreatic cancer cell invasion.

Kikuchi, A.; Harada, A.; Matsumoto, S.; Yasumizu, Y.; Akama, T.; Eguchi, H.

10.1101/2021.02.23.432112 — cancer biology — Posted on 2021-02-24

696 Protein Friction and Filament Bending Facilitate Contraction of Disordered Actomyosin Networks

Tam, A. K. Y.; Mogilner, A.; Oelz, D. B.

10.1101/2021.02.23.432588 — biophysics — Posted on 2021-02-24

697 Machine learning to predict the source of campylobacteriosis using whole genome data

Arning, N.; Sheppard, S. K.; Clifton, D. A.; Wilson, D. J.

10.1101/2021.02.23.432443 — bioinformatics — Posted on 2021-02-23

698 Automated classification of signal sources in mesoscale calcium imaging

Mullen, B. R.; Weiser, S. C.; Ascencio, D.; Ackman, J. B.

10.1101/2021.02.23.432573 — neuroscience — Posted on 2021-02-24

699 Antiparasitic effect of stilbene and terphenyl compounds against Trypanosoma cruzi parasites

Bruno, F.; Castelli, G.; Vitale, F.; Catanzaro, S.; Badaco, V. V.; Roberti, M.; Colomba, C.; Cascio, A.; Tolomeo, M.

10.1101/2021.02.23.432446 — microbiology — Posted on 2021-02-23

700 Developmental depression-facilitation shift controls excitation-inhibition balance

Jia, D. W.; Costa, R. P.; Vogels, T. P.

10.1101/2021.02.23.431593 — neuroscience — Posted on 2021-02-23

701 Design principles of acidic transcriptional activation domains

Staller, M. V.; Ramirez, E.; Holehouse, A. S.; Pappu, R. V.; Cohen, B. A.

10.1101/2020.10.28.359026 — systems biology — Posted on 2021-02-23

702 Validation of the Early Warning and Response System (EWARS) for dengue outbreaks: Evidence from the national vector control program in Mexico

Hussain-Alkhateeb, L.; Benitez-Valladares, D.; Kroeger, A.; Tejeda, G. S.

10.1101/2021.02.23.432448 — scientific communication and education — Posted on 2021-02-23

703 A large-scale transcriptome-wide association study (TWAS) of ten blood cell phenotypes reveals complexities of TWAS fine-mapping

Tapia, A. L.; Rowland, B. T.; Rosen, J. D.; Preuss, M.; Young, K.; Graff, M.; Choquet, H.; Couper, D. J.; Buyske, S.; Bien, S. A.; Jorgenson, E.; Kooperberg, C.; Loos, R. J. F.; Morrison, A. C.; North, K. E.; Yu, B.; Reiner, A. P.; Li, Y.; Raffield, L. M.

10.1101/2021.02.23.432444 — genetics — Posted on 2021-02-23

704 Core circadian clock transcription factor BMAL1 regulates mammary epithelial cell growth, differentiation, and milk component synthesis

Casey, T.; Suarez-Trujillo, A. M.; Cummings, S. M.; Huff, K.; Crodian, J.; Bhide, K. M.; Aduwari, C. M.; Teeple, K. M.; Shamay, A.; Mabjeesh, S. J.; San Miguel, P. M.; Thimmapuram, J. M.; Plaut, K. M.

10.1101/2021.02.23.432439 — cell biology — Posted on 2021-02-23

705 The nanoscale organization of the Wnt signaling integrator Dishevelled in the development-essential vegetal cortex domain of an egg and early embryo

Henson, J.; Samasa, B.; Shuster, C.; Wikramanayake, A.

10.1101/2021.02.23.432438 — cell biology — Posted on 2021-02-23

706 Epitranscriptomic addition of m6A regulates HIV-1 RNA stability and alternative splicing

Tsai, K.; Bogerd, H. P.; Kennedy, E. M.; Emery, A.; Swanstrom, R.; Cullen, B. R.

10.1101/2021.02.23.432449 — molecular biology — Posted on 2021-02-23

707 Improved transformation efficiency of group A Streptococcus by inactivation of a type I restriction modification system

Finn, M. B.; Ramsey, K. M.; Dove, S. L.; Wessels, M. R.

10.1101/2021.02.23.432441 — molecular biology — Posted on 2021-02-23

708 Increased biting rate and decreased Wolbachia density in irradiated mosquitoes: safety issues in the framework of genetic control strategies

Moretti, R.; Lampazzi, E.; Fabbri, G.; Lombardi, G.; Damiani, C.; Pioli, C.; Desiderio, A.; Serrao, A.; Calvitti, M.

10.1101/2021.02.23.432445 — microbiology — Posted on 2021-02-23

709 The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation

Meyers, J.; Ramanathan, M.; Shanderson, R.; Donohue, L.; Ferguson, I.; Guo, M.; Rao, D.; Miao, W.; Reynolds, D.; Yang, X.; Zhao, Y.; Yang, Y.-Y.; Wang, Y.; Khavari, P.

10.1101/2021.02.23.432450 — microbiology — Posted on 2021-02-23

710 The Mesodiencephalic Junction as a Central Hub for Cerebro-Cerebellar Communication

WANG, X.; Novello, M.; Gao, Z.; Ruigrok, T. J. H.; De Zeeuw, C. I.

10.1101/2021.02.23.432495 — neuroscience — Posted on 2021-02-23

711 A tale of two gradients: Differences between the left and right hemispheres predict semantic cognition and visual reasoning

Gonzalez Alam, T. R.; Mckeown, B. L. A.; Gao, Z.; Bernhardt, B.; Vos de Wael, R.; Margulies, D. S.; Smallwood, J.; Jefferies, E.

10.1101/2021.02.23.432529 — neuroscience — Posted on 2021-02-23

712 Dense Functional and Molecular Readout of a Circuit Hub in Sensory Cortex

Condylis, C.; Ghanbari, A.; Manjrekar, N.; Bistrong, K.; Yao, S.; Yao, Z.; Nguyen, T. N.; Zeng, H.; Tasic, B.; Chen, J. L.

10.1101/2021.02.23.432355 — neuroscience — Posted on 2021-02-23

713 Mask, the Drosophila Ankyrin Repeat and KH domain-containing protein, regulates microtubule dynamics

Martinez, D. A.; Zhu, M.; Guidry, J. J.; Majeste, N.; Mao, H.; Yanofsky, S.; Tian, X.; Wu, C.

10.1101/2020.04.22.056051 — neuroscience — Posted on 2021-02-23

714 Cellular, physiological, and behavioral validation of a CRFR1:Cre-tdTomato transgenic rat for use in basic neuroscience research

Weera, M. M.; Agoglia, A. E.; Douglass, E. A.; Jiang, Z.; Rajamanikam, S.; Shackett, R. S.; Justice, N. J.; Herman, M. A.; Gilpin, N. W.

10.1101/2021.02.23.432551 — neuroscience — Posted on 2021-02-23

715 Mitochondrial genome phylogeny of voles and lemmings (Rodentia: Arvicolinae): evolutionary and taxonomic implications

Abramson, N. I.; Bodrov, S. Y.; Bondareva, O. V.; Genelt-Yanovskiy, E. A.; Petrova, T. V.

10.1101/2021.02.23.432437 — zoology — Posted on 2021-02-23

716 Effect of exogenously applied alpha-tocopherol on vital agronomic, physiological and biochemical attributes of Lentil (Lens culinaris Medik.) under induced drought stress

Shah, W.; ullah, s.; Ali, S.; Idrees, M.; Khan, M. N.; Ali, K.; Khan, A.; Younas, F.; Ali, M.

10.1101/2021.02.23.432440 — plant biology — Posted on 2021-02-23

717 Cancer blues? A validated judgment bias task suggests pessimism in nude mice with tumors

Resasco, A.; MacLellan, A.; Ayala, M. A.; Kitchenham, L.; Edwards, M.; Lam, S.; Dejardin, S.; Mason, G.

10.1101/2021.02.13.431089 — animal behavior and cognition — Posted on 2021-02-23

718 Identification of promising oilseed rape genotypes for the tropical regions of Iran using multivariate analysis

Bakhshi, B.; Amiri Oghan, H.; Alizadeh, B.; Rameeh, V.; Payghamzadeh, K.; Kiani, D.; Rabiee, M.; Rezaizad, A.; Shiresmaeili, G.; Dalili, A.; Kia, S.

10.1101/2021.02.23.431199 — genetics — Posted on 2021-02-23

719 Dynamic evolution of MLKL in primate and poxvirus genomes indicates necroptosis is a critical, not auxiliary, countermeasure during infection

Palmer, S.; Chappidi, S.; Pinkham, C.; Hancks, D.

10.1101/2021.02.19.432003 — evolutionary biology — Posted on 2021-02-23

720 Host-specific gene expression as a tool for introduction success in populations of generalist Naupactus parthenogenetic weevils

Mackay-Smith, A.; Dornon, M. K.; Lucier, R.; Okimoto, A.; Mendonca de Sousa, F.; Rodriguero, M.; Confalonieri, V.; Lanteri, A.; Sequeira, A.

10.1101/2021.02.23.432442 — evolutionary biology — Posted on 2021-02-23

721 Genetic incompatibilities do not snowball in a demographic model of speciation

Maya-Lastra, C. A.; Eaton, D. A. R.

10.1101/2021.02.23.432472 — evolutionary biology — Posted on 2021-02-23

722 Constructing and validating a transferable epidemic risk index in data scarce environments using open data: a case study for dengue in the Philippines

Hierink, F.; Margutti, J.; van den Homberg, M.; Ray, N.

10.1101/2021.02.23.432447 — ecology — Posted on 2021-02-23

723 Surfactin stimulated by pectin molecular patterns and root exudates acts as a key driver of Bacillus-plant mutualistic interaction

Hoff, G.; Arguelles Arias, A.; Boubsi, F.; Prsic, J.; Meyer, T.; Ibrahim, H. M. M.; Steels, S.; Luzuriaga, P.; Legras, A.; Franzil, L.; Lequart, M.; Rayon, C.; Osorio, V.; de Pauw, E.; Lara, Y.; Deboever, E.; de Coninck, B.; Jacques, P.; Deleu, M.; Petit, E.; Van Wuytswinkel, O.; Ongena, M.

10.1101/2021.02.22.432335 — microbiology — Posted on 2021-02-23

724 Neural excitability and sensory input determine intensity perception with opposing directions in initial cortical responses

Stephani, T.; Hodapp, A.; Jamshidi Idaji, M.; Villringer, A.; Nikulin, V. V.

10.1101/2020.11.27.401430 — neuroscience — Posted on 2021-02-23

725 Automated Segmentation of Amyloid-β Stained Whole Slide Images of Brain Tissue

Lai, Z.; Guo, R.; Xu, W.; Hu, Z.; Mifflin, K.; DeCarli, C.; Dugger, B. N.; Cheung, S.-c.; Chuah, C.-N.

10.1101/2020.11.13.381871 — neuroscience — Posted on 2021-02-23

726 Ciliary neuropeptidergic signaling dynamically regulates excitatory synapses in postnatal neocortical pyramidal neurons

Tereshko, L. R.; Gao, Y.; Cary, B. A.; Turrigiano, G. G.; Sengupta, P.

10.1101/2020.12.10.419507 — neuroscience — Posted on 2021-02-23

727 Rewritable Two-Dimensional DNA-Based Data Storage with Machine Learning Reconstruction

Pan, C.; Tabatabaei, S. K.; Tabatabaei Yazdi, S. M. H.; Hernandez, A. G.; Schroeder, C. M.; Milenkovic, O.

10.1101/2021.02.22.432304 — synthetic biology — Posted on 2021-02-23

728 Genetically Engineered Strains for Combinatorial Cardiovascular Optobiology

10.1101/2021.01.21.427692 — physiology — Posted on 2021-02-23

729 Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1

Deng, Q.; Natesan, R.; Cidre-Aranaz, F.; Arif, S.; Liu, Y.; Rasool, R.; Wang, P.; Cramer, Z.; Chou, M.; Kumar-Sinha, C.; Weber, K.; Eisinger-Mathason, K.; Grillet, N.; Grunewald, T. G. P.; asangani, i. a.

10.1101/2021.02.22.432287 — cancer biology — Posted on 2021-02-23

730 Wrinkle force microscopy: a new machine learning based approach to predict cell mechanics from images

Li, H.; Matsunaga, D.; Matsui, T. S.; Aosaki, H.; Inoue, K.; Doostmohammadi, A.; Deguchi, S.

10.1101/2021.02.01.429065 — biophysics — Posted on 2021-02-23

731 BIAPSS - BioInformatic Analysis of liquid-liquid Phase-Separating protein Sequences

Badaczewska-Dawid, A.; Potoyan, D. A.

10.1101/2021.02.11.430806 — bioinformatics — Posted on 2021-02-23

732 DR2S: An Integrated Algorithm Providing Reference-Grade Haplotype Sequences from Heterozygous Samples

Klasberg, S.; Schmidt, A. H.; Lange, V.; Schöfl, G.

10.1101/2020.11.09.374140 — bioinformatics — Posted on 2021-02-23

733 Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale

Paramasivam, P.; Franke, C.; Stoeter, M.; Hoijer, A.; Bartesaghi, S.; Sabirsh, A.; Lindfors, L.; Yanez Arteta, M.; Dahlen, A.; Bak, A.; Andersson, S.; Kalaidzidis, Y.; Bickle, M.; Zerial, M.

10.1101/2020.12.18.423541 — bioengineering — Posted on 2021-02-23

734 SPIN - Species by Proteome INvestigation

Ruether, P. L.; Husic, I. M.; Bangsgaard, P.; Murphy Gregersen, K.; Pantmann, P.; Carvalho, M.; Godinho, R. M.; Friedl, L.; Cascalheira, J.; Joerkov, M. L. S.; Benedetti, M.; Haws, J.; Bicho, N.; Welker, F.; Cappellini, E.; Olsen, J. V.

10.1101/2021.02.23.432520 — biochemistry — Posted on 2021-02-23

735 Spatially-Resolved Proteomic Analysis of the Lens Extracellular Diffusion Barrier

Wang, Z.; Schey, K. L.

10.1101/2021.02.23.432581 — biochemistry — Posted on 2021-02-23

736 The Mammalian Cytosolic Type 2 (R)-β-hydroxybutyrate Dehydrogenase (BDH2) is 4-oxo-L-proline Reductase (EC1.1.1.104)

Kwiatkowski, S. P.; Bozko, M.; Zarod, M.; Witecka, A.; Jagielski, A. K.; Drozak, J.

10.1101/2021.02.23.432487 — biochemistry — Posted on 2021-02-23

737 TRex, a fast multi-animal tracking system with markerless identification, and 2D estimation of posture and visual fields

Walter, T.; Couzin, I. D.

10.1101/2020.10.14.338996 — animal behavior and cognition — Posted on 2021-02-23

738 Rickettsia japonica in ticks infesting a wild mammal in Thailand

Hirunkanokpun, S.; Ahantarig, A.; Baimai, V.; Trinachartvanit, W.

10.1101/2021.02.23.432398 — genetics — Posted on 2021-02-23

739 Genetic effects on brain traits impact cell-type specific gene regulation during neurogenesis

Aygün, N.; Elwell, A. L.; Liang, D.; Lafferty, M. J.; Cheek, K. E.; Courtney, K. P.; Mory, J.; Hadden-Ford, E.; Krupa, O.; de la Torre-Ubieta, L.; Geschwind, D. H.; Love, M. I.; Stein, J. L.

10.1101/2020.10.21.349019 — genetics — Posted on 2021-02-23

740 Mesoamerica is a cradle and the Atlantic Forest is a museum of Neotropical butterfly diversity: Insights from the evolution and biogeography of Brassolini (Lepidoptera: Nymphalidae)

Matos-Maravi, P.; Wahlberg, N.; Freitas, A. V. L.; DeVries, P. J.; Antonelli, A.; Penz, C.

10.1101/762393 — evolutionary biology — Posted on 2021-02-23

741 Changes in partner traits drive variation in plant-nectar robber interactions across habitats

Fitch, G.; Vandermeer, J. H.

10.1101/2020.01.09.898692 — ecology — Posted on 2021-02-23

742 Host-generalist fungal pathogens of seedlings may maintain forest diversity via host-specific impacts and differential susceptibility among tree species

Spear, E. R.; Broders, K.

10.1101/2020.12.24.424362 — ecology — Posted on 2021-02-23

743 Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex

Papagiannidis, D.; Bircham, P. W.; Luechtenborg, C.; Ruffini, G.; Bruegger, B.; Schuck, S.

10.1101/2020.02.23.961722 — cell biology — Posted on 2021-02-23

744 Engineering of a fluorescent chemogenetic reporter with tunable color for advanced live-cell imaging

Benaissa, H.; Ounoughi, K.; Aujard, I.; Fischer, E.; Goïame, R.; Nguyen, J.; Tebo, A. G.; Li, C.; Le Saux, T.; Danglot, L.; Pietrancosta, N.; Morin, X.; Jullien, L.; Gautier, A.

10.1101/2021.01.29.428635 — molecular biology — Posted on 2021-02-23

745 Hypusinated eIF5A is required for the translation of collagen

Alepuz, P.; Barba, M.; Mena, A.; Espinoza, V.; Apostolova, N.; Costell, M.

10.1101/2021.02.23.432471 — molecular biology — Posted on 2021-02-23

746 IN VITRO ANTI-VIRAL ACTIVITY OF HEXETIDINE (BACTIDOL) ORAL MOUTHWASH AGAINST HUMAN CORONAVIRUS OC43 ANDINFLUENZA A (H1N1) VIRUS

Altura, M. T.; Ngelangel, C. A.

10.1101/2021.02.11.430728 — microbiology — Posted on 2021-02-23

747 Structure and variability of optogenetic responses identify the operating regime of cortex

Palmigiano, A.; Fumarola, F.; Mossing, D. P.; Kraynyukova, N.; Adesnik, H.; Miller, K.

10.1101/2020.11.11.378729 — neuroscience — Posted on 2021-02-23

748 Perceptual difficulty modulates the direction of information flow in familiar face recognition

Karimi-Rouzbahani, H.; Ramezani, F.; Woolgar, A.; Rich, A. N.; Ghodrati, M.

10.1101/2020.08.10.245241 — neuroscience — Posted on 2021-02-23

749 Reward enhances online participants' engagement with a demanding auditory task

Bianco, R.; Mills, G.; De Kerangal, M.; Rosen, S.; Chait, M.

10.1101/2021.02.09.430467 — neuroscience — Posted on 2021-02-23

750 Endocrine fine-tuning of daily locomotor activity patterns under non-starving conditions in Drosophila

Pauls, D.; Selcho, M.; Raederscheidt, J.; Amatobi, K. M.; Fekete, A.; Krischke, M.; Hermann-Luibl, C.; Uenal, A. G.; Ehmann, N.; Itskov, P. M.; Helfrich-Foerster, C.; Kuehnlein, R. P.; Mueller, M. J.; Wegener, C.

10.1101/2020.02.13.947556 — neuroscience — Posted on 2021-02-23

751 Parallel processing of natural images by overlapping retinal neuronal ensembles

Perez-Ortega, J. E.; Araya, J.; Ibaceta, C.; Herzog, R.; Escobar, M.-J.; Pena-Ortega, F.; Carillo-Reid, L.; Palacios, A. G.

10.1101/2021.02.22.432289 — neuroscience — Posted on 2021-02-23

752 Low-frequency neural tracking of speech envelope reflects the convolution of evoked responses to acoustic edges, not oscillatory entrainment

Kojima, K.; Oganian, Y.; Cai, C.; Findlay, A.; Chang, E. F.; Nagarajan, S.

10.1101/2020.04.02.022616 — neuroscience — Posted on 2021-02-23

753 Diffuse optical reconstructions of NIRS data using Maximum Entropy on the Mean

Cai, Z.; Machado, A.; Chowdhury, R. A.; Spilkin, A.; Vincent, T.; Aydin, U.; Pellegrino, G.; Lina, J.-M.; Grova, C.

10.1101/2021.02.22.432263 — neuroscience — Posted on 2021-02-23

754 Elucidation of Japanese pepper (Zanthoxylum piperitum De Candolle) domestication using RAD-Seq

Premarathne, M. D. G. P.; Fukutome, N.; Yamasaki, K.; Hayakawa, F.; Nagano, A. J.; Mizuno, H.; Ibaragi, N.; Nagano, Y.

10.1101/2020.12.29.424752 — plant biology — Posted on 2021-02-23

755 Impact of an oral amino acid provision on Achilles peritendinous amino acid concentrations in young and older adults

Carroll, C. C.; Couture, S.; Farino, D. O.; Patel, S. H.; Campbell, N. W.; Stout, J.; Sabbaghi, A.

10.1101/2021.02.12.430945 — physiology — Posted on 2021-02-23

756 Somatic hypomethylation of pericentromeric SST1 repeats and tetraploidization in human colorectal cancer cells

Gonzalez, B.; Navarro-Jimenez, M.; Alonso-De Gennaro, M. J.; Jansen, S. M.; Granada, I.; Perucho, M.; Alonso, S.

10.1101/2021.02.19.431645 — cancer biology — Posted on 2021-02-23

757 Quantification and demonstration of the collective constriction-by-ratchet mechanism in the dynamin molecular motor

Ganichkin, O.; Vancraenenbroeck, R.; Rosenblum, G.; Hofmann, H.; Mikhailov, A. S.; Daumke, O.; Noel, J. K.

10.1101/2020.09.10.289546 — biophysics — Posted on 2021-02-23

758 A fast and efficient smoothing approach to Lasso regression and an application in statistical genetics: polygenic risk scores for chronic obstructive pulmonary disease (COPD)

Hahn, G.; Lutz, S. M.; Laha, N.; Cho, M. H.; Silverman, E. K.; Lange, C.

10.1101/2020.03.06.980953 — bioinformatics — Posted on 2021-02-23

759 Activity-based urinary biomarkers of response and resistance to checkpoint blockade immunotherapy

Mac, Q. D.; Xu, C.; Bowen, J. R.; Sivakumar, A.; Phuengkham, H.; Su, F.-Y.; Stentz, S. Z.; Sim, H.; Harris, A. M.; Li, T. T.; Qiu, P.; Kwong, G. A.

10.1101/2020.12.10.420265 — bioengineering — Posted on 2021-02-23

760 Epigenetic age is accelerated in schizophrenia with age- and sex-specific effects and associated with polygenic disease risk

Ori, A. P.; Olde Loohuis, L. M.; Guintivano, J.; Hannon, E.; Dempster, E.; St. Clair, D.; Bass, N. J.; McQuillin, A.; Mill, J.; Sullivan, P. F.; Kahn, R. S.; Horvath, S.; Ophoff, R. A.

10.1101/727859 — genomics — Posted on 2021-02-23

761 Evolution Without Variation and Selection

Gabora, L.; Steel, M.

10.1101/2020.08.30.274407 — evolutionary biology — Posted on 2021-02-23

762 Adaptation and correlated fitness responses over two time scales in Drosophila suzukii populations evolving in different environments

Olazcuaga, L.; Foucaud, J.; Gautier, M.; Deschamps, C.; Loiseau, A.; Lemenager, N.; Facon, B.; Ravigne, V.; Hufbauer, R. A.; Estoup, A.; Rode, N. O.

10.1101/749945 — evolutionary biology — Posted on 2021-02-23

763 Sweeps in time: leveraging the joint distribution of branch lengths

Bisschop, G.; Lohse, K.; Setter, D.

10.1101/2021.01.27.428367 — evolutionary biology — Posted on 2021-02-23

764 Cardiac pathologies in mouse loss of imprinting models are due to misexpression of H19 long noncoding RNA

Pfeifer, K.; Park, K.-S.; Rahat, B.; Yu, Z.-X.; Noeker, J.; Mitra, A.; Knutsen, R.; Springer, D.; Kozel, B.

10.1101/2021.02.23.432554 — developmental biology — Posted on 2021-02-23

765 DLG2 knockout reveals neurogenic transcriptional programs underlying neuropsychiatric disorders and cognition

Sanders, B.; D'Andrea, D.; Collins, M. O.; Rees, E. E.; Steward, T. G. J.; Zhu, Y.; Chapman, G.; Legge, S. E.; Pardinas, A. F.; Harwood, A. J.; Gray, W. P.; O'Donovan, M. C.; Owen, M. J.; Errington, A. C.; Blake, D. J.; Whitcomb, D. J.; Pocklington, A. J.; Shin, E.

10.1101/2020.01.10.898676 — developmental biology — Posted on 2021-02-23

766 A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental genes partitioning in Toxoplasma

Farhat, D. C.; Bowler, M. W.; Communie, G.; PONTIER, D.; Belmudes, L.; MAS, C.; Corrao, C.; COUTE, Y.; BOUGDOUR, A.; LAGRANGE, T.; HAKIMI, M.-a.; Swale, C.

10.1101/2021.02.23.432502 — microbiology — Posted on 2021-02-23

767 Forward genetics in Wolbachia: Regulation of Wolbachia proliferation by the amplification and deletion of an addictive genomic island

Duarte, E. H.; Carvalho, A.; Lopez-Madrigal, S.; Costa, J.; Teixeira, L.

10.1101/2020.09.08.288217 — microbiology — Posted on 2021-02-23

768 Model-based inference of neutralizing antibody avidities against influenza virus

Linnik, J.; Syedbasha, M.; Hollenstein, Y.; Halter, J.; Egli, A.; Stelling, J.

10.1101/2020.10.05.326215 — immunology — Posted on 2021-02-23

769 Using EEG Microstates to Examine Post-Encoding Quiet Rest and Subsequent Word-Pair Memory

Poskanzer, C.; Denis, D.; Herrick, A.; Stickgold, R.

10.1101/2020.05.08.085027 — neuroscience — Posted on 2021-02-23

770 Alpha fluctuations regulate the accrual of visual information to awareness

Torralba Cuello, M.; Drew, A.; Sabate San Jose, A.; Moris Fernandez, L.; Soto Faraco, S.

10.1101/2020.09.16.298166 — neuroscience — Posted on 2021-02-23

771 Reward-specific satiety affects subjective economic value coding of orbitofrontal cortex neurons

Pastor-Bernier, A.; Stasiak, A.; Schultz, W.

10.1101/2020.07.04.187518 — neuroscience — Posted on 2021-02-23

772 Aging predisposes B cells to malignancy by activating c-Myc and perturbing the genome and epigenome

Shindyapina, A. V.; Castro, J. P.; Barbieri, A.; Strelkova, O. S.; Paulo, J. A.; Kerepesi, C.; Petrashen, A. P.; Mariotti, M.; Meer, M.; Hu, Y.; Losyev, G.; Indzhykulian, A. A.; Gygi, S. P.; Sedivy, J. M.; Manis, J. P.; Gladyshev, V. N.

10.1101/2021.02.23.432500 — cancer biology — Posted on 2021-02-23

773 Longitudinal preclinical imaging characterization of drug delivery potential after radiotherapy in the healthy and leukemic bone marrow vascular microenvironment

Brooks, J.; Zuro, D.; Song, J. Y.; Madabushi, S. S.; Sanchez, J. F.; Kortylewski, M.; Chen, B. T.; Gupta, K.; Storme, G.; Froelich, J.; Hui, S. K.

10.1101/2021.02.23.432514 — cancer biology — Posted on 2021-02-23

774 Consequences of the constitutive NOX2 activity in living cells: cytosol acidification, apoptosis, and localized lipid peroxidation

Valenta, H.; Dupre-Crochet, S.; Bizouarn, T.; Baciou, L.; Nüsse, O.; Deniset-Besseau, A.; Erard, M.

10.1101/2021.02.23.429648 — biophysics — Posted on 2021-02-23

775 MetaPro: A scalable and reproducible data processing and analysis pipeline for metatranscriptomic investigation of microbial communities

Taj, B.; Adeolu, M.; Xiong, X.; Nursimulu, N.; Ang, J.; Parkinson, J.

10.1101/2021.02.23.432558 — bioinformatics — Posted on 2021-02-23

776 Structure and dynamics of a cold-active esterase reveals water entropy and active site accessibility as the likely drivers for cold-adaptation

Noby, N.; Sabah Auhim, H.; Johnson, R.; Worthy, H.; Embady, a.; Saeed, H.; Hussein, A.; Rizkallah, P.; Wells, S. A.; Jones, D.

10.1101/2021.02.23.432564 — biochemistry — Posted on 2021-02-23

777 Structure guided engineering of a cold active esterase expands substrate range though a stabilisation mutation that allows access to a buried water chamber

Noby, N.; Johnson, R.; Tyzack, J.; Embaby, A.; Saeed, H.; Hussein, A.; Khattab, S.; Rizkallah, P.; Jones, D.

10.1101/2021.02.23.432567 — biochemistry — Posted on 2021-02-23

778 Blood progenitor redox homeostasis through GABA control of TCA cycle in Drosophila hematopoiesis

Mukherjee, T.; Goyal, M.; Tomar, A.; Madhwal, S.

10.1101/2021.02.23.432543 — developmental biology — Posted on 2021-02-23

779 Glypiation enables FGF to self-regulate its tissue-specific dispersion and interpretation through cytonemes

Du, L.; Sohr, A.; Roy, S.

10.1101/2021.02.23.432493 — developmental biology — Posted on 2021-02-23

780 FORMATION OF LIPOFUSCIN-LIKE AUTOFLUORESCENT GRANULES IN THE RETINAL PIGMENT EPITHELIUM REQUIRES LYSOSOME DYSFUNCTION

Escrevente, C.; Falcao, A. S.; Hall, M. J.; Lopes-da-Silva, M.; Antas, P.; Mesquita, M. M.; Ferreira, I. S.; Cardoso, M. H.; Fradinho, A. C.; Futter, C. E.; Tenreiro, S.; Seabra, M. C.

10.1101/2021.02.23.432539 — cell biology — Posted on 2021-02-23

781 A Phosphorylated Histone H2A Variant Displays Properties of Chromatin Insulator Proteins in Drosophila

Simmons, J. R.; An, R.; Amankwaa, B.; Zayac, S.; Kemp, J.; Labrador, M.

10.1101/2021.02.23.432395 — molecular biology — Posted on 2021-02-23

782 Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses

Nambulli, S.; Xiang, Y.; Tilston-Lunel, N. L.; Rennick, L. J.; Sang, Z.; Klimstra, W. B.; Reed, D. S.; Crossland, N. A.; Shi, Y.; Duprex, P. W.

10.1101/2021.02.23.432569 — microbiology — Posted on 2021-02-23

783 Potassium isomerized linoleate satisfies EPA MB-35-00 for surface disinfection of Candida auris (AR-0381)

Changaris, D.; Carenbauer, A. L.

10.1101/2021.02.23.432518 — microbiology — Posted on 2021-02-23

784 Draft metagenomes of endolithic cyanobacteria and co-habitants from hyper-arid deserts

Murray, B.; Dailey, M.; Ertekin, E.; DiRuggiero, J.

10.1101/2021.02.23.432541 — microbiology — Posted on 2021-02-23

785 Oral Hsp90 inhibitor, SNX-5422, attenuates SARS-CoV-2 replication and dampens inflammation in airway cells.

Goswami, R.; Russell, V. S.; Tu, J. J.; Hughes, P.; Kelly, F.; Langel, S. N.; Steppe, J.; Palmer, S. M.; Haystead, T.; Blasi, M.; Permar, S. R.

10.1101/2021.02.23.432479 — microbiology — Posted on 2021-02-23

786 Using mixed-effects modeling to estimate decay kinetics of response to SARS-CoV-2 infection

Bottino, D.; Hather, G.; Yuan, L.; Stoddard, M.; White, L.; Chakravarty, A.

10.1101/2021.02.22.432379 — immunology — Posted on 2021-02-23

787 Arkadia-SKI/SnoN signaling cascade differentially regulates TGF-β-induced iTreg and Th17 cell differentiation

Xu, H.; Wu, L.; Nguyen, H.; Mesa, K. R.; Raghavan, V.; Episkopou, V.; Littman, D. R.

10.1101/2021.02.23.432519 — immunology — Posted on 2021-02-23

788 Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pRab10

Wang, X.; Negrou, E.; Maloney, M. T.; Bondar, V. V.; Andrews, S. V.; Montalban, M.; Llapashtica, C.; Maciuca, R.; Nguyen, H.; Solanoy, H.; Arguello, A.; Przybyla, L.; Moerke, N. J.; Huntwork-Rodriguez, S.; Henry, A. G.

10.1101/2021.02.23.432545 — neuroscience — Posted on 2021-02-23

789 REPROGRAMMING CBX8-PRC1 FUNCTION WITH A POSITIVE ALLOSTERIC MODULATOR

Suh, J. L.; Bsteh, D.; Si, Y.; Hart, B.; Weaver, T. M.; Pribitzer, C.; Lau, R.; Soni, S.; Ogana, H.; Rectenwald, J. M.; Norris, J. L.; Cholensky, S. H.; Sagum, C.; Umana, J. D.; Li, D.; Hardy, B.; Bedford, M. T.; Mumenthaler, S. M.; Lenz, H.-J.; Kim, Y.-m.; Wang, G. G.; Pearce, K. H.; James, L.; Kireev, D. B.; Musselman, C. A.; Frye, S. V.; Bell, O.

10.1101/2021.02.23.432388 — synthetic biology — Posted on 2021-02-23

790 Lactic Acid Production by Clostridium acetobutylicum and Clostridium beijerinckii Under Anaerobic Conditions Using a Complex Substrate

Mattiello-Francisco, L.; Moreira Vieira, F.; Peixoto, G.; Mockaitis, G.

10.1101/2021.02.23.432258 — bioengineering — Posted on 2021-02-23

791 Structural Basis for SARS-CoV-2 Envelope Protein in Recognition of Human Cell Junction Protein PALS1

Chai, J.; Cai, Y.; Pang, C.; Wang, L.; McSweeney, S.; Shanklin, J.; Liu, Q.

10.1101/2021.02.22.432373 — biochemistry — Posted on 2021-02-23

792 Metagenomic diagnosis and pathogenic network profile of SARS-CoV-2 in patients co-morbidly affected by type 2 diabetes

Al-Emran, H. M.; Rahman, M. S.; Hasan, M. S.; Alam, A. S. M. R. U.; Islam, O. K.; Anwar, A.; Jahid, I. K.; Hossain, M. A.

10.1101/2021.02.23.432535 — genomics — Posted on 2021-02-23

793 Comprehensive evaluation of ACE2 expression in female ovary by single-cell RNA-seq analysis

Kong, S.; Yan, Z.; Yuan, P.; Liu, X.; Chen, Y.; Yang, M.; Chen, W.; Song, S.; Yan, J.; Yan, L.; Qiao, J.

10.1101/2021.02.23.432460 — developmental biology — Posted on 2021-02-23

794 Single Unit Analysis and Wide-Field Imaging Reveal Alterations in Excitatory andInhibitory Neurons in Glioma

Gill, B. J. A.; Khan, F. A.; Merricks, E. M.; Goldberg, A. R.; Wu, X.; Sosunov, A. A.; Sudhakar, T.; Liou, J.-y.; Dovas, A.; McKhann, G. M.; Canoll, P.; Schevon, C.

10.1101/2021.02.23.432381 — cancer biology — Posted on 2021-02-23

795 Scientific modelling can be accessible, interoperable and user friendly: An example for pasture and livestock modelling

Marquez Torres, A.; Balbi, S.; Villa, F.

10.1101/2021.02.23.432363 — ecology — Posted on 2021-02-23

796 3D viscoelastic drag forces drive changes to cell shapes during organogenesis in the zebrafish embryo

Sanematsu, P. C.; Erdemci-Tandogan, G.; Patel, H.; Retzlaff, E.; Amack, J. D.; Manning, L.

10.1101/2021.02.23.432503 — developmental biology — Posted on 2021-02-23

797 Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum

Lu, C.-L.; Cain, J.; Brudvig, J.; Ortmeier, S.; Boyadjiev, S.; Weimer, J. M.; Kim, J.

10.1101/2021.02.23.431880 — cell biology — Posted on 2021-02-23

798 Naegleria's mitotic spindles are built from unique tubulins and highlight core spindle features

Velle, K. B.; Trupinic, M.; Ivec, A.; Swafford, A.; Nolton, E.; Rice, L.; Tolic, I. M.; Fritz-Laylin, L. K.; Wadsworth, P.

10.1101/2021.02.23.432318 — cell biology — Posted on 2021-02-23

799 CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection

Lu, Y.-J.; Barreira-Silva, P.; Boyce, S.; Powers, J.; Cavallo, K.; Behar, S. M.

10.1101/2021.02.23.432461 — immunology — Posted on 2021-02-23

800 p16-3MR: a novel model to study cellular senescence in cigarette smoke-induced lung injuries during aging

Kaur, G.; Sundr, I.; Rahman, I.

10.1101/2021.02.23.432412 — pharmacology and toxicology — Posted on 2021-02-23

801 The periodic axon membrane skeleton leads to high-density sodium nanodomains but does not impact action potentials

Chai, Z.; Tzingounis, A. V.; Lykotrafitis, G.

10.1101/2021.02.23.432468 — biophysics — Posted on 2021-02-23

802 Sphingolipid Control of Fibroblast Heterogeneity Revealed by Single-Cell Lipidomics

Capolupo, L.; Khven, I.; Mazzeo, L.; Glousker, G.; Russo, F.; Paz Montoya, J.; Ho, S.; Bhandari, D. R.; Bowman, A. P.; Ellis, S.; Guiet, R.; Muthing, J.; Spengler, B.; Heeren, R. M. A.; Dotto, G.-P.; La Manno, G.; D'Angelo, G.

10.1101/2021.02.23.432420 — biochemistry — Posted on 2021-02-23

803 Fluctuating environments maintain genetic diversity through neutral fitness effects and balancing selection

Abdul-Rahman, F.; Tranchina, D.; Gresham, D.

10.1101/2021.02.23.432553 — evolutionary biology — Posted on 2021-02-23

804 The Good, the Bad and the Stochastic: How Living in Groups Innately Supports Cooperation

Steiner, K. F.

10.1101/2021.02.21.431661 — evolutionary biology — Posted on 2021-02-23

805 Deletion of Fibroblast growth factor 9 globally and in skeletal muscle results in enlarged tuberosities at sites of deltoid tendon attachments

Leek, C. C.; Soulas, J. M.; Bhattacharya, I.; Ganji, E.; Locke, R. C.; Smith, M. C.; Bhavsar, J. D.; Polson, S. W.; Ornitz, D.; Killian, M. L.

10.1101/2021.02.23.432498 — developmental biology — Posted on 2021-02-23

806 Clinical Phage Microbiology:A suggested framework and recommendations for the in-vitro matching steps ‎of phage therapy

Gelman, D.; Yerushalmy, O.; Ben-Porat, S.; Rakov, C.; Alkalay-Oren, S.; Adler, K.; Khalifa, L.; Abdalrhman, M.; Coppenhagen-Glazer, S.; Aslam, S.; Schooley, R. T.; Nir-Paz, R.; Hazan, R.

10.1101/2021.02.23.432393 — microbiology — Posted on 2021-02-23

807 Stabilin-1 plays a protective role against Listeria monocytogenes infection through the regulation of cytokine and chemokine production and immune cell recruitment

Pombinho, R.; Pinheiro, J.; Resende, M.; Meireles, D.; Jalkanen, S.; Sousa, S.; Cabanes, D.

10.1101/2021.02.23.432451 — microbiology — Posted on 2021-02-23

808 Cross-sectional analysis of the microbiota of the human gut and their direct environment (exposome) in a household cohort in northern Vietnam.

Vu Thi Ngoc, B.; Ho Bich, H.; Galazzo, G.; Vu Tien Viet, D.; Oomen, M.; Nghiem Nguyen Minh, T.; Tran Huy, H.; Van Doorn, R.; Wertheim, H. F.; Penders, J.

10.1101/2021.02.23.432416 — microbiology — Posted on 2021-02-23

809 Single-cell sequencing characterizes intratumoral profile of immune cells in old mice

Zhang, C.; Lei, L.; Yang, X.; Zheng, H.; Su, Y.; Jiao, A.; Wang, X.; Liu, H.; Zou, Y.; Shi, L.; Zhou, X.; Sun, C.; Zhang, L.; Hou, Y.; Xiao, Z.; Zhang, B.

10.1101/2021.02.23.432366 — immunology — Posted on 2021-02-23

810 Resting-state theta oscillations and reward sensitivity in risk taking

Azanova, M.; Herrojo Ruiz, M.; Belianin, A. V.; Klucharev, V.; Nikulin, V. V.

10.1101/2021.02.23.432425 — neuroscience — Posted on 2021-02-23

811 Lynx1 modulates the activity of nAChRs to slow NMJ and muscle fiber degeneration during aging

Doss, S. V.; Barbat-Artigas, S.; Myers, T.; Pradhan, B. S.; Proszynski, T. J.; Robitaille, R.; Valdez, G.

10.1101/2020.05.29.123851 — neuroscience — Posted on 2021-02-23

812 Targeted comodulation supports flexible and accurate decoding in V1

Haimerl, C.; Ruff, D. A.; Cohen, M. R.; Savin, C.; Simoncelli, E. P.

10.1101/2021.02.23.432351 — neuroscience — Posted on 2021-02-23

813 A new two-generation approach to the population dynamics of gregarious parasitoids

Samkova, A.; Raska, J.; Hadrava, J.; Skuhrovec, J.

10.1101/2021.02.22.432341 — zoology — Posted on 2021-02-23

814 Circadian Transcriptomic and Epigenomic Remodeling in Response to Lipid Overload and Human Obesity

Sardon Puig, L.; Altintas, A.; Casani, S.; Gabriel, B. M.; Barres, R.; Conesa, A.; Chibalin, A. V.; Naslund, E.; Krook, A.; Pillon, N. J.; Zierath, J. R.

10.1101/2021.02.23.432336 — physiology — Posted on 2021-02-23

815 Mass cytometry reveals immunological response to radiation-induced cardiac fibrosis in mice

Tang, Y.; Wang, B.; Sun, M.; Liu, P.; Zhang, X.; You, M.; Xia, B.

10.1101/2021.02.23.432001 — cancer biology — Posted on 2021-02-23

816 Structural and functional characterization of SARS-CoV-2 RBD domains produced in mammalian cells

Gstoettner, C.; Zhang, T.; Resemann, A.; Ruben, S.; Pengelley, S.; Suckau, D.; Welsink, T.; Wuhrer, M.; Dominguez-Vega, E.

10.1101/2021.02.23.432424 — biochemistry — Posted on 2021-02-23

817 Adult zebrafish anaesthesia: a study of efficacy and behavioural recovery of different anaesthetics

Jorge, S.; Ferreira, J.; Olsson, A.; Valentim, A. M.

10.1101/2021.02.23.432432 — animal behavior and cognition — Posted on 2021-02-23

818 Chromatin reader Dido3 regulates the genetic network of B cell differentiation

Gutierrez del Burgo, F.; Pons, T.; Vazquez de Luis, E.; Martinez-A, C.; Villares, R.

10.1101/2021.02.23.432411 — molecular biology — Posted on 2021-02-23

819 A monocyte/dendritic cell molecular signature of SARS-CoV2-related multisystem inflammatory syndrome in children (MIS-C) with severe myocarditis

de Cevins, C.; Luka, M.; Smith, N.; Meynier, S.; Magerus, A.; Carbone, F.; Garcia Paredes, V.; Barnabei, L.; Batignes, M.; Boulle, A.; Stolzenberg, M.-C.; Perot, B. P.; Charbit, B.; Fali, T.; Pirabarakan, V.; Sorin, B.; Riller, Q.; Abdessalem, G.; Beretta, M.; Grzelak, L.; Goncalves, P.; Di Santo, J. P.; Mouquet, H.; Schwartz, O.; Zarhrate, M.; Parisot, M.; Bole-Feysot, C.; Masson, C.; Cagnard, N.; Corneau, A.; Bruneau, C.; Zhang, S.-Y.; Casanova, J.-L.; Bader Meunier, B.; Haroche, J.; Melki, I.; Lorrot, M.; Oualha, M.; Moulin, F.; Bonnet, D.; Belhadjer, Z.; Leruez, M.; Allali, S.; Gras Leguen

10.1101/2021.02.23.432486 — immunology — Posted on 2021-02-23

820 At the Intersection Between SARS-CoV-2, Macrophages and the Adaptive Immune Response: A Key Role for Antibody-Dependent Pathogenesis But Not Enhancement of Infection in COVID-19

DeMarco, J. K.; Severson, W.; DeMarco, D.; Pogue, G.; Gabbard, J. D.; Palmer, K. E.

10.1101/2021.02.22.432407 — immunology — Posted on 2021-02-23

821 Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection.

Ma, L.; Sahu, S. K.; Cano, M.; Kuppuswamy, V.; Bajwa, J.; McPhatter, J.; Pine, A. B.; Meizlish, M. M.; Goshua, G.; Chang, C. H.; Zhang, H.; Price, C.; Bahel, P.; Rinder, H. M.; Lei, T.; Day, A.; Reynolds, D.; Wu, X.; Schriefer, R.; Rauseo, A. M.; Goss, C. W.; O'Halloran, J. A.; Presti, R. M.; Kim, A. H.; Gelman, A. E.; Dela Cruz, C. S.; Lee, A. I.; Mudd, P. A.; Chun, H. J.; Atkinson, J. P.; Kulkarni, H. S.

10.1101/2021.02.22.432177 — immunology — Posted on 2021-02-23

822 SARS-CoV-2 causes brain inflammation and induces Lewy body formation in macaques

Philippens, I. H. C. H. M.; Boszormenyi, K. P.; Wubben, J. A.; Fagrouch, Z. C.; van Driel, N.; Mayenburg, A. Q.; Lozovagia, D.; Roos, E.; Schurink, B.; Bugiani, M.; Bontrop, R. E.; Middeldorp, J.; Bogers, W. M.; de Geus-Oei, L.-F.; Langermans, J. A. M.; Stammes, M. A.; Verstrepen, B. E.; Verschoor, E. J.

10.1101/2021.02.23.432474 — neuroscience — Posted on 2021-02-23

823 Human basigin (CD147) does not directly interact with SARS-CoV-2 spike glycoprotein

Ragotte, R. J.; Pulido, D.; Donnellan, F. R.; Gorini, G.; Davies, H.; Brun, J.; King, L. D.; Skinner, K.; Draper, S. J.

10.1101/2021.02.22.432402 — biochemistry — Posted on 2021-02-23

824 Histone H2Bub1 deubiquitylation is essential for mouse development, but does not regulate global RNA polymerase II transcription

Wang, F.; El-Saafin, F.; Ye, T.; Stierle, M.; Negroni, L.; Durik, M.; Fischer, V.; Devys, D.; Vincent, S. D.; Tora, L.

10.1101/2021.02.23.432458 — molecular biology — Posted on 2021-02-23

825 Broad influence of mutant ataxin-3 on the proteome of the adult brain, young neurons, and axons reveals central molecular processes and biomarkers in SCA3/MJD using knock-in mouse model

Wiatr, K.; Marczak, L.; Perot, J.-B.; Brouillet, E.; Flament, J.; Figiel, M.

10.1101/2021.02.23.432266 — neuroscience — Posted on 2021-02-23

826 A preliminary assessment of allostatic load in male mantled howler monkeys

Dias, P. A. D.; Coyohua Fuentes, A.; Chavira Ramirez, D. R.; Canales Espinosa, D.; Rangel Negrin, A.

10.1101/2021.02.22.432350 — zoology — Posted on 2021-02-23

827 Systems approaches identify the consequences ofmonosomy in somatic human cells

Chunduri, N. K.; Menges, P.; Gotsmann, V. L.; Zhang, X.; Mardin, B. R.; Buccitelli, C.; Korbel, J. O.; Willmund, F.; Kschischo, M.; Raeschle, M.; Storchova, Z.

10.1101/2021.02.22.432226 — systems biology — Posted on 2021-02-23

828 macroH2A2 shapes chromatin accessibility at enhancer elements in glioblastoma to modulate a targetable self-renewal epigenetic network

Nikolic, A.; Bobyn, A.; Maule, F.; Ellestad, K.; Lun, X.; Johnston, M.; Gafuik, C.; Zemp, F.; Ninkovic, N.; Marhon, S.; Mehdipour, P.; Shen, Y.; Berger, D.; Brownsey, D.; Dirks, P.; Derksen, D.; Jones, S.; de Carvalho, D.; Senger, D.; Chan, J.; Mahoney, D.; Gallo, M.

10.1101/2021.02.23.432465 — cancer biology — Posted on 2021-02-23

829 Multi-fluorescence high-resolution episcopic microscopy (MF-HREM) for three dimensional imaging of adult murine organs

Walsh, C.; Holroyd, N.; Finnerty, E.; Ryan, S. G.; Sweeney, P. W.; Shipley, R. J.; Walker-Samuel, S.

10.1101/2020.04.03.023978 — biophysics — Posted on 2021-02-23

830 Local topology, bifurcations and mutation hot-spots in proteins with SARS-CoV-2 spike protein as an example

Peng, X.; Niemi, A. J.

10.1101/2020.11.11.378828 — biophysics — Posted on 2021-02-23

831 Visualizing multi-protein patterns at the synapse of neuronal tissue with DNA-assisted single-molecule localization microscopy

Narayanasamy, K. K.; Stojic, A.; Li, Y.; Sass, S.; Hesse, M.; Deussner-Helfmann, N. S.; Dietz, M. S.; Klevanski, M.; Kuner, T.; Heilemann, M.

10.1101/2021.02.23.432306 — biophysics — Posted on 2021-02-23

832 SARS-CoV-2 lineage B.1.526 emerging in the New York region detected by software utility created to query the spike mutational landscape

West, A. P.; Barnes, C. O.; Yang, Z.; Bjorkman, P. J.

10.1101/2021.02.14.431043 — bioinformatics — Posted on 2021-02-23

833 Acidogenic Fermentation of Sugarcane Vinasse and Glucose Using Two Different Anaerobic Digestion Inocula

Martins, J.; Valenca de Araujo, H.; Mockaitis, G.; da Silva, A. J.

10.1101/2021.02.22.432247 — bioengineering — Posted on 2021-02-23

834 Hydrophobic-cationic peptides enhance RNA polymerase ribozyme activity by accretion

Li, P.; Holliger, P.; Tagami, S.

10.1101/2021.02.22.432394 — biochemistry — Posted on 2021-02-23

835 A copper chaperone-mimetic polytherapy for SOD1-associated amyotrophic lateral sclerosis

McAlary, L.; Shephard, V. K.; Wright, G. S.; Yerbury, J. J.

10.1101/2021.02.22.432389 — biochemistry — Posted on 2021-02-23

836 Dominance shifts increase the likelihood of soft selective sweeps

Muralidhar, P.; Veller, C.

10.1101/2021.02.22.432386 — evolutionary biology — Posted on 2021-02-23

837 Beneficial cumulative effects of old parental age on offspring fitness

Travers, L. M.; Carlsson, H.; Lind, M. I.; Maklakov, A. A.

10.1101/2021.02.22.432223 — evolutionary biology — Posted on 2021-02-23

838 Solving the Sample Size Problem for Resource Selection Analysis

Street, G. M.; Potts, J. R.; Borger, L.; Beasley, J.; Demarais, S.; Fryxell, J. M.; McLoughlin, P.; Monteith, K.; Prokopenko, C.; Ribeiro, M.; Rodgers, A.; Strickland, B.; Van Beest, F.; Bernasconi, D.; Beumer, L.; Dharmarajan, G.; Dwinnell, S.; Keiter, D.; Keuroghlian, A.; Newediuk, L.; Oshima, J.; Rhodes, O.; Schlichting, P.; Schmidt, N.; Vander Wal, E.

10.1101/2021.02.22.432319 — ecology — Posted on 2021-02-23

839 Dietary vitamin B12 reduces amyloid-β proteotoxicity by alleviating oxidative stress and mitochondrial dysfunction

Lam, A.; Kervin, K.; Tanis, J. E.

10.1101/2021.02.22.432392 — cell biology — Posted on 2021-02-23

840 Targeting CoV-2 Spike RBD and ACE-2 Interaction with Flavonoids of Anatolian Propolis by in silico and in vitro Studies in terms of possible COVID-19 therapeutics

Guler, H. I.; Ay Sal, F.; Can, Z.; Kara, Y.; Yildiz, O.; Belduz, A. O.; Canakci, S.; Kolayli, S.

10.1101/2021.02.22.432207 — molecular biology — Posted on 2021-02-23

841 Chelator sensing and lipopeptide interplay mediates molecular interspecies interactions between soil bacilli and pseudomonads

Andric, S.; Meyer, T.; Rigolet, A.; Arguelles Arias, A.; Steels, S.; Hoff, G.; Hofte, M.; De Mot, R.; McCann, A.; De Pauw, E.; Ongena, M.

10.1101/2021.02.22.432387 — microbiology — Posted on 2021-02-23

842 Crystal structure of Sulfolobus solfataricus topoisomerase III reveals a novel carboxyl-terminal zinc finger domain essential for decatenation activity

Wang, H.; Zhang, J.; Gao, Z.; Zheng, X.; Zhu, K.; Zhang, Z.; Zhang, Z.; Dong, Y.; Huang, L.; Gong, Y.

10.1101/706986 — microbiology — Posted on 2021-02-23

843 Ultrafast large-scale simulations of biophysically realistic neurons using deep learning

Olah, V. J.; Pedersen, N. P.; Rowan, M. J.

10.1101/2021.02.22.432356 — neuroscience — Posted on 2021-02-23

844 Modeling metallicity: low level visual features support robust material perception

Harvey, J. S.; Smithson, H. E.

10.1101/2021.02.22.432364 — neuroscience — Posted on 2021-02-23

845 Sulfur limitation increases duckweed starch accumulation without compromising growth

Sun, Z.; Guo, W.; Zhao, X.; Yang, J.; Duan, P.; Xu, S.; Hou, H.

10.1101/2021.02.22.432231 — plant biology — Posted on 2021-02-23

846 Apple ripening is controlled by a NAC transcription factor

Migicovsky, Z.; Yeats, T. H.; Watts, S.; Song, J.; Forney, C. F.; Burgher-MacLellan, K.; Somers, D. J.; Gong, Y.; Zhang, Z.; Vrebalov, J.; Giovannoni, J. G.; Rose, J. K. C.; Myles, S.

10.1101/708040 — plant biology — Posted on 2021-02-23

847 Pulsatile contractions and pattern formation in excitable active gels

Staddon, M. F.; Munro, E.; Banerjee, S.

10.1101/2021.02.22.432369 — biophysics — Posted on 2021-02-23

848 Forecasting symptomatic influenza A infection based on pre-exposure gene expression using a Deep Learning approach

Zan, A.; Xie, Z.-R.; Hsu, Y.-C.; Chen, Y.-H.; Lin, T.-H.; Chang, Y.-S.; Chang, K. Y.

10.1101/2020.12.02.407940 — bioinformatics — Posted on 2021-02-23

849 BiSEK: a platform for a reliable differential expression analysis

Haas, R.; Light, D.; Festinger, Y.; Friedman, N.; Lamm, A.

10.1101/2021.02.22.432271 — bioinformatics — Posted on 2021-02-23

850 TP-MAP - an Integrated Software Package for the Analysis of 1D and 2D Thermal Profiling Data

Huber, K. V. M.; Feyertag, F.

10.1101/2021.02.22.432361 — bioinformatics — Posted on 2021-02-23

851 DeepMotifSyn: a deep learning approach to synthesize heterodimeric DNA motifs

Lin, J.; Huang, L.; Chen, X.; Zhang, S.; Wong, K.-C.

10.1101/2021.02.22.432257 — bioinformatics — Posted on 2021-02-23

852 clusTCR: a Python interface for rapid clustering of large sets of CDR3 sequences

Valkiers, S.; Van Houcke, M.; Laukens, K.; Meysman, P.

10.1101/2021.02.22.432291 — bioinformatics — Posted on 2021-02-23

853 Chemoproteomics Enabled Discovery of Selective Probes for NuA4 Factor BRD8

Remillard, D.; Savage, N. A.; Kedves, A. T.; Paulk, J.; Chen, X.; Garcia, F. J.; Romanowski, M. J.; Horton, P. A.; Murphy, J.; Schirle, M.; Harrington, E. M.; Maxwell, M. B.; Pham, H. T.; Maksimovic, I.; Thomas, J. R.; Forrester, W. C.

10.1101/2021.02.22.432362 — biochemistry — Posted on 2021-02-23

854 Seven amino acid types suffice to reconstruct the core fold of RNA polymerase

Yagi, S.; Padhi, A. K.; Vucinic, J.; Barbe, S.; Schiex, T.; Nakagawa, R.; Simoncini, D.; Zhang, K. Y. J.; Tagami, S.

10.1101/2021.02.22.432383 — biochemistry — Posted on 2021-02-23

855 Male mate choice unresolved in the mangrove rivulus

Gresham, J. D.; Earley, R. L.

10.1101/2021.02.22.432326 — animal behavior and cognition — Posted on 2021-02-23

856 A more accurate method for colocalisation analysis allowing for multiple causal variants

Wallace, C.

10.1101/2021.02.23.432421 — genetics — Posted on 2021-02-23

857 Variation in self-compatibility among genotypes and across ontogeny in a self-fertilizing vertebrate

Gresham, J. D.; Earley, R. L.

10.1101/2021.02.22.432320 — evolutionary biology — Posted on 2021-02-23

858 High-order interactions maintain or enhance structural robustness of a coffee agroecosystem network

Gonzalez Gonzalez, C.; Mora Van Cauwelaert, E.; Boyer, D.; Perfecto, I.; Vandermeer, J.; Benitez Keinrad, M.

10.1101/2021.02.22.432328 — ecology — Posted on 2021-02-23

859 The multidimensional nutritional niche of fungus-cultivar provisioning in free-ranging colonies of a neotropical leafcutter ant

Crumiere, A. J. J.; James, A.; Lannes, P.; Mallett, S.; Michelsen, A.; Rinnan, R.; Shik, J. Z.

10.1101/2021.02.22.432261 — ecology — Posted on 2021-02-23

860 Protocol for mapping the spatial variability in cell wall mechanical bending behavior in living leaf pavement cells

Li, W.; Keynia, S.; Belteton, S.; Afshar-Hatam, F.; Szymanski, D. B.; Turner, J. A.

10.1101/2021.02.23.432478 — cell biology — Posted on 2021-02-23

861 Frequency of quorum sensing mutations in Pseudomonas aeruginosa strains isolated from different environments

O'Connor, K.; Zhao, C. Y.; Diggle, S. P.

10.1101/2021.02.22.432365 — microbiology — Posted on 2021-02-23

862 Pectin induced colony expansion of soil-derived Flavobacterium strains

Kraut-Cohen, J.; Shapiro, O. H.; Dror, B.; Cytryn, E.

10.1101/2020.06.26.174714 — microbiology — Posted on 2021-02-23

863 improv: A flexible software platform for adaptive neuroscience experiments

Draelos, A.; Nikitchenko, M.; Sriworarat, C.; Sprague, D.; Loring, M. D.; Pnevmatikakis, E.; Giovannucci, A.; Naumann, E. A.; Pearson, J. M.

10.1101/2021.02.22.432006 — neuroscience — Posted on 2021-02-23

864 Hierarchical cross-scale analysis identifies parallel ventral striatal networks coding for dynamic and stabilized olfactory reward predictions

Winkelmeier, L.; Filosa, C.; Scheller, M.; Hartig, R.; Sack, M.; Becker, R.; Wolf, D.; Reinwald, J.; Gerchen, M. F.; Sartorius, A.; Meyer-Lindenberg, A.; Weber-Fahr, W.; Clemm von Hohenberg, C.; Russo, E.; Kelsch, W.

10.1101/2021.02.22.432268 — neuroscience — Posted on 2021-02-23

865 Suppression of alpha-band power underlies exogenous attention to emotional distractors

Arana, L.; Melcon, M.; Kessel, D.; Hoyos, S.; Albert, J.; Carretie, L.; Capilla, A.

10.1101/2021.02.22.432307 — neuroscience — Posted on 2021-02-23

866 Diffuse optical reconstructions of NIRS data using Maximum Entropy on the Mean

Cai, Z.; Machado, A.; Chowdhury, R. A.; Spilkin, A.; Vincent, T.; Aydin, U.; Pellegrino, G.; Lina, J.-M.; Grova, C.

10.1101/2021.02.22.432263 — neuroscience — Posted on 2021-02-23

867 Parallel processing of natural images by overlapping retinal neuronal ensembles

Perez-Ortega, J. E.; Araya, J.; Ibaceta, C.; Herzog, R.; Escobar, M.-J.; Pena-Ortega, F.; Carillo-Reid, L.; Palacios, A. G.

10.1101/2021.02.22.432289 — neuroscience — Posted on 2021-02-23

868 Unexpected false feelings of familiarity about faces are associated with increased pupil dilations

Manning, J. R.; Ziman, K.

10.1101/2021.02.22.432360 — neuroscience — Posted on 2021-02-23

869 Partitioning variability in animal behavioral videos using semi-supervised variational autoencoders

Whiteway, M. R.; Biderman, D.; Friedman, Y.; Dipoppa, M.; Buchanan, E. K.; Wu, A.; Zhou, J.; Noel, J.-P. R.; The International Brain Lab, ; Cunningham, J. P.; Paninski, L.

10.1101/2021.02.22.432309 — neuroscience — Posted on 2021-02-23

870 The amyloid concentric β-barrel hypothesis: models of Synuclein oligomers, annular protofibrils, lipoproteins, and transmembrane channels.

Durell, S.; Guy, H. R.

10.1101/2021.02.22.432295 — neuroscience — Posted on 2021-02-23

871 Functional modules within a distributed neural network control feeding in a model medusa

Weissbourd, B.; Momose, T.; Nair, A.; Kennedy, A.; Hunt, B.; Anderson, D. J.

10.1101/2021.02.22.432372 — neuroscience — Posted on 2021-02-23

872 Connectome-based individual prediction of cognitive behaviors via the graph propagation network reveals directed brain network topology

Wu, D.; Li, X.; Feng, J.

10.1101/2021.02.22.432377 — neuroscience — Posted on 2021-02-23

873 Analysing variations in pelage patterning among European Felis silvestris silvestris populations

Reher, D.; Stefen, C.

10.1101/2021.02.22.432262 — zoology — Posted on 2021-02-23

874 Rewritable Two-Dimensional DNA-Based Data Storage with Machine Learning Reconstruction

Pan, C.; Tabatabaei, K.; Tabatabaei Yazdi, S. M. H.; Hernandez, A. G.; Schroeder, C. M.; Milenkovic, O.

10.1101/2021.02.22.432304 — synthetic biology — Posted on 2021-02-23

875 Clinically-Driven Design of Synthetic Gene Regulatory Programs in Human Cells

Israni, D. V.; LI, H.; Gagnon, K. A.; Sander, J. D.; Roybal, K. T.; Joung, J. K.; Wong, W.; Khalil, A. S.

10.1101/2021.02.22.432371 — synthetic biology — Posted on 2021-02-23

876 An evolutionarily conserved coreceptor gene is essential for CLAVATA signaling in Marchantia polymorpha

Takahashi, G.; Betsuyaku, S.; Okuzumi, N.; Kiyosue, T.; Hirakawa, Y.

10.1101/2021.02.22.427935 — plant biology — Posted on 2021-02-23

877 Chaperones Skp and SurA dynamically expand unfolded outer membrane protein X and synergistically disassemble oligomeric aggregates

Chamachi, N.; Hartmann, A.; Ma, M. Q.; Krainer, G.; Schlierf, M.

10.1101/2021.02.23.432414 — biophysics — Posted on 2021-02-23

878 The contribution of electrostatics to hydrogen exchange in the unfolded protein state

Dass, R.; Corlianò, E.; Mulder, F. A.

10.1101/2021.02.22.432104 — biophysics — Posted on 2021-02-23

879 Lipid type doping of the sponge (L3) mesophase

Brasnett, C.; Squires, A.; Smith, A.; Seddon, A.

10.1101/2021.02.22.432284 — biophysics — Posted on 2021-02-23

880 Protein-protein docking with large-scale backbone flexibility

Kurcinski, M.; Kmiecik, S.; Zalewski, M.; Kolinski, A.

10.1101/2021.02.22.432196 — bioinformatics — Posted on 2021-02-23

881 Designing of multiepitope-based vaccine against Leptospirosis using Immuno-Informatics approaches.

Abdullah, M.; Kadivella, M.; Sharma, R.; Faisal, S. M.; Azam, S.

10.1101/2021.02.22.431920 — bioinformatics — Posted on 2021-02-23

882 Milk-Way Algorithm applied in Imbalanced Dataset

Leite, C. F. V.; Dos Santos, M. A.

10.1101/2021.02.22.432316 — bioinformatics — Posted on 2021-02-23

883 Bone mechanoregulation allows subject-specific load estimation based on time-lapsed micro-CT and HR-pQCT in vivo

Walle, M.; Marques, F. C.; Ohs, N.; Blauth, M.; Müller, R.; Collins, C. J.

10.1101/2021.02.22.431960 — bioengineering — Posted on 2021-02-23

884 Effect of Initial pH and Organic Matter Concentration on Production of Volatile Organic Acids Through Acidogenesis of Sugarcane Vinasse

Martins, J.; Valenca de Araujo, H.; Mockaitis, G.; da Silva, A. J.

10.1101/2021.02.22.432232 — bioengineering — Posted on 2021-02-23

885 Dependency of Lower Limb Joint Reaction Forces on Femoral Anteversion

Modenese, L.; Barzan, M.; Carty, C. P.

10.1101/2021.02.22.432159 — bioengineering — Posted on 2021-02-23

886 NanoTox: Development of a parsimonious in silico model for toxicity assessment of metal-oxide nanoparticles using physicochemical features

AnanthaSubramanian, N.; Palaniappan, A.

10.1101/2021.02.22.432301 — bioengineering — Posted on 2021-02-23

887 ERICA: Emulated Retinal Image CApture - A tool for testing, training and validating retinal image processing methods

Young, L. K.; Smithson, H. E.

10.1101/2021.02.22.432253 — bioengineering — Posted on 2021-02-23

888 Conformity leading self-organised rescue from suboptimally biased risky decision-making

Toyokawa, W.; Gaissmaier, W.

10.1101/2021.02.22.432286 — animal behavior and cognition — Posted on 2021-02-23

889 The Rise of West Nile Virus in Europe: investigatingthe combined effects of climate, land use and economic changes

Watts, M. J.

10.1101/2021.02.22.432294 — ecology — Posted on 2021-02-23

890 RGG-motif protein Sbp1 is required for Processing body (P-body) disassembly

Roy, R.; Kuttanda, I. A.; Bhatter, N.; Rajyaguru, P. I.

10.1101/2021.02.23.432385 — cell biology — Posted on 2021-02-23

891 The G2-phase enriched lncRNA SNHG26 is necessary for proper cell cycle progression and proliferation

Samdal, H.; Hegre, S. A.; Chawla, K.; Liabakk, N.-B.; Aas, P. A.; Sporsheim, B.; Saetrom, P.

10.1101/2021.02.22.432245 — molecular biology — Posted on 2021-02-23

892 Epigenetic rewriting at centromeric DNA repeats leads to increased chromatin accessibility and chromosomal instability

Decombe, S.; Loll, F.; Caccianini, L.; Affannoukoue, K.; Izeddin, I.; Mozziconacci, J.; Escude, C.; Lopes, J.

10.1101/2021.02.22.432244 — molecular biology — Posted on 2021-02-23

893 Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity

Weerakoon, H.; Straube, J.; Lineburg, K.; Cooper, L.; Lane, S.; Smith, C.; Alabbas, S.; Begun, J.; Miles, J. J.; Hill, M. M.; Lepletier, A.

10.1101/2021.02.22.432185 — immunology — Posted on 2021-02-23

894 Human immunodeficiency reveals GIMAP5 as lymphocyte-specific regulator of senescence

Park, A. Y.; Leney-Greene, M.; Lynberg, M.; Xu, X.; Zheng, L.; Zhang, Y.; Matthews, H.; Chao, B.; Morawski, A.; Jiang, P.; Aluri, J.; Aydine, E. K.; Kiykim, A.; Pascall, J.; Barlan, I.; Sari, S.; Butcher, G.; Rao, V. K.; Lifton, R. P.; Baris, S.; Ozen, A.; Vilarinho, S.; Su, H.; Lenardo, M. J.

10.1101/2021.02.22.432146 — immunology — Posted on 2021-02-23

895 pyControl: Open source, Python based, hardware and software for controlling behavioural neuroscience experiments.

Akam, T.; Lustig, A.; Rowland, J.; Kapanaiah, S. K. T.; Esteve-Agraz, J.; Panniello, M.; Marquez, C.; Kohl, M.; Kätzel, D.; Costa, R. M.; Walton, M. E.

10.1101/2021.02.22.432227 — neuroscience — Posted on 2021-02-23

896 Loss of FAS1 function reveals rescue of an aberrant intra-S-phase checkpoint by the G2/M checkpoint regulator SOG1

Eekhout, T.; Dvorackova, M.; Pedroza Garcia, J.; Nespor Dadejova, M.; Kalhorzadeh, P.; Van den Daele, H.; Vercauteren, I.; Fajkus, J.; De Veylder, L.

10.1101/2021.02.22.432330 — plant biology — Posted on 2021-02-23

897 TPX2 Amplification-Driven Aberrant Mitosis in Long-Term Cultured Human Embryonic Stem Cells

Jeong, H.-C.; Go, Y.-H.; Shin, J.-G.; Kim, Y.-J.; Cho, M.-G.; Gwon, D.; Cheong, H. S.; Lee, H.; Lee, J.-H.; Jang, C.-Y.; Shin, H. D.; Cha, H.-J.

10.1101/2021.02.22.432205 — cell biology — Posted on 2021-02-23

898 Loss of Muscleblind Splicing Factor Shortens C. elegans Lifespan by Reducing the Activity of p38 MAPK/PMK-1 and Transcription Factors ATF-7 and Nrf/SKN-1

Matilainen, O. J.; Ribeiro, A. R.; Verbeeren, J.; Cetinbas, M.; Sadreyev, R.; Garcia, S.

10.1101/2021.02.22.432374 — genetics — Posted on 2021-02-23

899 Single cell trajectory analysis of human pluripotent stem cells differentiating towards lung and hepatocyte progenitors

Ori, C.; Ansari, M.; Angelidis, I.; Theis, F. J.; Schiller, H. B.; Drukker, M.

10.1101/2021.02.23.432413 — developmental biology — Posted on 2021-02-23

900 NF-kB-repressed Sirt3 mediates testicular cholesterol metabolism and cytoskeleton assembly by P450scc/SOD2 deacetylation

Wang, M.; Zeng, L.; Xiong, Y.; Wang, X.-f.; Cheng, L.; Wang, F.; Su, P.; Zhang, Y.-z.

10.1101/2021.02.22.432399 — developmental biology — Posted on 2021-02-23

901 Cubam receptor-mediated endocytosis in hindgut-derived pseudoplacenta of a viviparous teleost Xenotoca eiseni

Iida, A.; Sano, K.; Inokuchi, M.; Nomura, J.; Suzuki, T.; Kuriki, M.; Sogabe, M.; Susaki, D.; Tonosaki, K.; Kinoshita, T.; Hondo, E.

10.1101/2021.02.01.429082 — zoology — Posted on 2021-02-23

902 Mitogenomic Phylogeny of Callithrix with Special Focus on Human Transferred Taxa

Malukiewicz, J.; Cartwright, R. A.; Curi, N. H.; Dergam, J. A.; Igayara, C. S.; Moreira, S. B.; Molina, C. V.; Nicola, P. A.; Noll, A.; Passamani, M.; Pereira, L. C.; Pissinatti, A.; Ruiz-Miranda, C. R.; Silva, D. L.; Stone, A. C.; Zinner, D.; Roos, C.

10.1101/2020.08.12.247692 — genomics — Posted on 2021-02-23

903 TGF-beta promotes microtube formation in glioblastoma through Thrombospondin 1

Joseph, J. V.; Magaut, C. R.; Storevik, S.; Geraldo, L. H.; Mathivet, T.; Latif, A. M.; Rudewicz, J.; Guyon, J.; Gambaretti, M.; Haukas, F.; Trones, A.; Ystaas, L. A. R.; Hossain, J. A.; Ninzima, S.; Zhou, W.; Tomar, T.; Klink, B.; Rane, L.; Irving, B. K.; Marrison, J.; O Toole, P.; Wurdak, H.; Wang, J.; Di, Z.; Winkler, F.; Kruyt, F. A.; Bikfalvi, A.; Bjerkvig, R.; Daubon, T.; Miletic, H.

10.1101/2021.02.22.431443 — cancer biology — Posted on 2021-02-22

904 Spontaneous adaptation of ion selectivity in a bacterial flagellar motor

Ridone, P.; Ishida, T.; Sowa, Y.; Baker, M. A.

10.1101/2021.01.26.427765 — microbiology — Posted on 2021-02-22

905 Learning an efficient hippocampal place map from entorhinal inputs using non-negative sparse coding

Lian, Y.; Burkitt, A. N.

10.1101/2020.08.12.248534 — neuroscience — Posted on 2021-02-22

906 Raven: a de novo genome assembler for long reads

Vaser, R.; Sikic, M.

10.1101/2020.08.07.242461 — bioinformatics — Posted on 2021-02-22

907 A combined EM and proteomic analysis places HIV-1 Vpu at the crossroads of retromer and ESCRT complexes: PTPN23 is a Vpu-cofactor

Stoneham, C. A.; Langer, S.; De Jesus, P.; Wozniak, J.; Lapek, J.; Deerinck, T.; Thor, A.; Pache, L.; Chanda, S.; Gonzalez, D.; Ellisman, M.; Guatelli, J.

10.1101/2021.02.22.432252 — microbiology — Posted on 2021-02-22

908 Trends in community- and nosocomial-acquired infections of carbapenem resistant Enterobacteriaceae (CRE), carbapenemase producing Enterobacteriaceae (CPE) and vancomycin resistant Enterococcus (VRE): a 10-year prospective observational study.

Ubillus Arriola, G. M.; Araujo Banchon, W. E.; Patino Gabriel, L.; Kolevic, L.; Quispe Manco, M. d. C. M.; Olivo Lopez, J. M.; Barrientos Achata, A. M.; Bouzid, D.; Revilla Velasquez, M. E.; Casalino, E.

10.1101/2021.02.22.432249 — microbiology — Posted on 2021-02-22

909 A massive 7T fMRI dataset to bridge cognitive and computational neuroscience

Allen, E. J.; St-Yves, G.; Wu, Y.; Breedlove, J. L.; Dowdle, L. T.; Caron, B.; Pestilli, F.; Charest, I.; Hutchinson, J. B.; Naselaris, T.; Kay, K.

10.1101/2021.02.22.432340 — neuroscience — Posted on 2021-02-22

910 Large-scale cortical connectivity dynamics of intrinsic neural oscillations support adaptive listening behavior

Alavash, M.; Tune, S.; Obleser, J.

10.1101/2021.02.22.432315 — neuroscience — Posted on 2021-02-22

911 Planum Temporale grey matter volume asymmetries in new-born monkeys (Papio anubis)

Becker, Y.; Phelipon, R.; Sein, J.; Velly, L.; Renaud, L.; Meguerditchian, A.

10.1101/2021.02.22.432274 — neuroscience — Posted on 2021-02-22

912 The Optimum Cut-off Value of the Nelwan Score to Diagnose Typhoid Fever in Adults

Nelwan, E.; Paramita, L. P. L.; Sinto, R.; Hosea, F. N.; Nugroho, P.; Pohan, H.

10.1101/2021.02.22.432239 — pathology — Posted on 2021-02-22

913 Genetic diversity and population history of eight Italian beef cattle breeds using measures of autozygosity

Fabbri, M. C.; Dadousis, C.; Tiezzi, F.; Maltecca, C.; Lozada-Soto, E.; Biffani, S.; Bozzi, R.

10.1101/2021.02.22.432240 — genomics — Posted on 2021-02-22

914 Locus-specific H3K9me3 gain in aged somatic tissues in Caenorhabditis elegans

Li, C.-L.; Lee, S. S.; Pu, M.; Wang, W.

10.1101/2021.02.22.432236 — genomics — Posted on 2021-02-22

915 Mutational sources of trans-regulatory variation affecting gene expression in Saccharomyces cerevisiae

Duveau, F.; Vande Zande, P.; Metzger, B. P. H.; Diaz, C. J.; Walker, E. A.; Tryban, S.; Siddiq, M. A.; Yang, B.; Wittkopp, P. J.

10.1101/2021.02.22.432283 — genetics — Posted on 2021-02-22

916 Genetic mapping and identification of a QTL determining tolerance to freezing stress in Fragaria vesca L.

Davik, J.; Wilson, R. C.; Njah, R. G.; Grini, P. E.; Randall, S. K.; Alsheikh, M. K.; Sargent, D. J.

10.1101/2021.02.22.432243 — genetics — Posted on 2021-02-22

917 RELATIONSHIP BETWEEN PARENTAL AGE AND SEVERITY OF OROFACIAL CLEFTS

Adamson, O. O.; Oladugba, A.; Alade, A.; Awotoye, W.; Busch, T.; Li, M.; Fashina, A.; Olotu, J.; Sule, V.; James, O.; Ogunlewe, M.; Adeyemo, W.; Butali, A.

10.1101/2021.02.22.432246 — genetics — Posted on 2021-02-22

918 Combined application of biochar with nitrogen fertilizer improves soil quality and reduces soil respiration whilst sustaining wheat grain yield in a semiarid environment

Yeboah, S.; Jun, W.; Liqun, C.; Oteng-Darko, P.; Renzhi, Z.

10.1101/2021.02.22.432242 — ecology — Posted on 2021-02-22

919 The last battle of Anne of Brittany: solving mass grave through an interdisciplinary approach (paleopathology, anthropobiology, history, multiple isotopes and radiocarbon dating)

Colleter, R.; Bataille, C.; Milano, S.; Dabernat, H.; Trost, M.; Marchal, M.; Guilbeau-Frugier, C.; Pichot, D.; Hamon, P.; Labaune-Jean, F.; Jean, S.; Le Cloirec, G.; Steinbrenner, S.; Duchesne, S.; Telmon, N.; Crubezy, E.; Jaouen, K.

10.1101/2021.02.22.432237 — ecology — Posted on 2021-02-22

920 Regulation of Jacobaea vulgaris by varied cutting and restoration measures

Möhler, H.; Diekötter, T.; Donath, T. W.

10.1101/2021.02.22.432250 — ecology — Posted on 2021-02-22

921 The non-benzodiazepine anxiolytic etifoxine limits the sensory-affective expression of pain following streptozotocin-induced diabetic neuropathy

Gazzo, G.; Salgado-Ferrer, M.; Poisbeau, P.

10.1101/2021.02.22.432248 — neuroscience — Posted on 2021-02-22

922 Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1

asangani, i. a.; Deng, Q.; Natesan, R.; Cidre-Aranaz, F.; Arif, S.; Liu, Y.; Rasool, R.; Wang, P.; Cramer, Z.; Chou, M.; Kumar-Sinha, C.; Weber, K.; Eisinger-Mathason, K.; Grillet, N.; Grunewald, T. G. P.

10.1101/2021.02.22.432287 — cancer biology — Posted on 2021-02-22

923 Indirect restoration of ecological interactions: reintroduction of a dung-beetle associated primate increases the recruitment of large seeds

Rebello Landim, A.; A. S. Fernandez, F.; S. Pires, A.

10.1101/2021.01.20.427460 — ecology — Posted on 2021-02-22

924 A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion and virulence in the malaria parasite Plasmodium falciparum

MIAO, J.; Wang, C.; Lucky, A.; Liang, X.; Min, H.; Adapa, S. R.; Jiang, R.; Kim, K.; Cui, L.

10.1101/2021.02.03.429532 — microbiology — Posted on 2021-02-22

925 Isolation and characterisation of bacteriophages with activity against invasive non-typhoidal Salmonella causing bloodstream infection in Malawi

Rodwell, E. V.; Wenner, N.; Pulford, C. V.; Cai, Y.; Bowers-Barnard, A.; Beckett, A.; Rigby, J.; Picton, D. M.; Blower, T. R.; Feasey, N. A.; Hinton, J. C. D.; Perez-Sepulveda, B. M.

10.1101/2021.02.18.431836 — microbiology — Posted on 2021-02-22

926 Dynamic Predictive Coding with Hypernetworks

Jiang, L. P.; Gklezakos, D. C.; Rao, R. P. N.

10.1101/2021.02.22.432194 — neuroscience — Posted on 2021-02-22

927 Descending neocortical output critical for skilled forelimb movements is distributed across projection cell classes

Park, J.; Phillips, J. A.; Martin, K. A.; Hantman, A. W.; Dudman, J. T.

10.1101/772517 — neuroscience — Posted on 2021-02-22

928 Astrocyte-derived TNF and glutamate critically modulate microglia reactivity by methamphetamine

Canedo, T.; Portugal, C. C.; Socodato, R.; Bravo, J.; Almeida, T. O.; Magalhaes, J. D.; Guerra-Gomes, S.; Oliveira, J. F.; Sousa, N.; Magalhaes, A.; Relvas, J. B.; Summavielle, T.

10.1101/2021.02.22.432170 — neuroscience — Posted on 2021-02-22

929 Grapevine rootstocks affect growth-related scion phenotypes

Migicovsky, Z.; Cousins, P.; Jordan, L. M.; Myles, S.; Striegler, R. K.; Verdegaal, P.; Chitwood, D. H.

10.1101/864850 — plant biology — Posted on 2021-02-22

930 Regulation of large-conductance Ca2+- and voltage-gated K+ channels by electrostatic interactions with auxiliary β subunits.

Tian, Y.; Heinemann, S. H.; Hoshi, T.

10.1101/2021.02.22.432338 — physiology — Posted on 2021-02-22

931 Flanker: a tool for comparative genomics of gene flanking regions

Matlock, W.; Lipworth, S.; Constantinides, B.; Peto, T. E. A.; Walker, A. S.; Crook, D. W.; Hopkins, S.; Shaw, L. P.; Stoesser, N.

10.1101/2021.02.22.432255 — bioinformatics — Posted on 2021-02-22

932 Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs.

Papaioannou, A.; Centonze, F. G.; Metais, A.; Maurel, M.; Negroni, L.; Gonzales-Quiroz, M.; Zare Golchesmeh, E.; Blondel, A.; Koong, A. C.; Hetz, C.; Pedeux, R.; Tremblay, M. L.; Eriksson, L. A.; chevet, e.

10.1101/2020.03.02.972950 — biochemistry — Posted on 2021-02-22

933 Genome and transcriptome of a pathogenic yeast, Candida nivariensis

Fan, Y.; Gale, A.; Bailey, A.; Barnes, K.; Colotti, K.; Mass, M.; Morina, L. B.; Robertson, B.; Schwab, R.; Tselepidakis, N.; Timp, W.

10.1101/2021.01.27.428461 — genomics — Posted on 2021-02-22

934 Alteration of gut microbiota with a broad-spectrum antibiotic does not impair maternal care in the European earwig.

Van Meyel, S.; Devers, S.; Dupont, S.; Dedeine, F.; Meunier, J.

10.1101/2020.10.08.331363 — evolutionary biology — Posted on 2021-02-22

935 Dynamics of hunchback translation in real time and at single mRNA resolution in the Drosophila embryo

Vinter, D. J.; Hoppe, C.; Minchington, T. G.; Sutcliffe, C.; Ashe, H.

10.1101/2021.02.16.430474 — developmental biology — Posted on 2021-02-22

936 Targeting CoV-2 Spike RBD and ACE-2 Interaction with Flavonoids of Anatolian Propolis by in silico and in vitro Studies in terms of possible COVID-19 therapeutics

GULER, H. I.; AY SAL, F.; CAN, Z.; KARA, Y.; BELDUZ, A. O.; CANAKCI, S.; KOLAYLI, S.

10.1101/2021.02.22.432207 — molecular biology — Posted on 2021-02-22

937 Establishment of Culex modestus in Belgium and a glance into the virome of Belgian mosquito species

Wang, L.; Rosales Rosas, A. L.; De Coninck, L.; Shi, C.; Bouckaert, J.; Matthijnssens, J.; Delang, L.

10.1101/2020.11.27.401372 — microbiology — Posted on 2021-02-22

938 A novel DNA-binding protein regulates sexual differentiation in malaria parasites and is essential for transmission.

Campelo Morillo, R.; Tong, X.; Xie, W.; Lenz, T.; Batugedara, G.; Tabassum, N.; Orchard, L. M.; Daher, W.; Patel, D.; Noble, W. S.; Llinas, M.; Le Roch, K. G.; Kafsack, B. F. C.

10.1101/2020.10.26.352583 — microbiology — Posted on 2021-02-22

939 Glyphosate Inhibits Melanization and Increases Susceptibility to Infection in Insects

Smith, D. F. Q.; Camacho, E.; Thakur, R.; Barron, A. J.; Dong, Y.; Dimopoulos, G.; Broderick, N. A.; Casadevall, A.

10.1101/2020.05.20.105353 — microbiology — Posted on 2021-02-22

940 Sialic acid ligands of CD28 block co-stimulation of T cells

Edgar, L. J.; Thompson, A. J.; Vartabedian, V. F.; Kikuchi, C.; Woehl, J. L.; Teijaro, J. R.; Paulson, J. C.

10.1101/2021.02.22.432333 — immunology — Posted on 2021-02-22

941 How human runners regulate footsteps on uneven terrain

Dhawale, N.; Venkadesan, M.

10.1101/2021.02.22.432238 — neuroscience — Posted on 2021-02-22

942 Female manipulation of offspring sex ratio in the gregarious parasitoid Anaphes flavipes from a new two-generation approach

Samkova, A.; Raska, J.; Hadrava, J.; Skuhrovec, J.; Jansta, P.

10.1101/2021.02.22.432331 — zoology — Posted on 2021-02-22

943 Pharmacokinetics of Orally Administered GS-441524 in Dogs

Yan, V. C.; Khadka, S.; Arthur, K.; Pham, C.-D.; Yan, M. J.; Yan, A. J.; Ackroyd, J. J.; Georgiou, D. K.; Muller, F. L.

10.1101/2021.02.04.429674 — pharmacology and toxicology — Posted on 2021-02-22

944 Human immunocompetent Organs-on-Chips platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies

Cabon, L.; Petropolis, D.; Tien-Street, W.; Ng, P. R.; Grant, H. S.; Karalis, K.; Hamilton, G. A.; Sam, J.; Weinzierl, T.; Fauti, T.; Freimoser-Grundschober, A.; Eckmann, J.; Hage, C.; Geiger, M.; Micallef, V.; Gerard, R.; Bscheider, M.; Breous-Nystrom, E.; Schneider, A.; Giusti, A. M.; Bertinetti-Lapatki, C.; Roth, A. B.; Singer, T.; Kanellias, M.; Manatakis, D. V.; Moisan, A.; Bruenker, P.; Klein, C.; Bacac, M.; Gjorevski, N.; Belgur, C.; Kerns, S. J.; Barrile, R.

10.1101/2021.02.22.432308 — cancer biology — Posted on 2021-02-22

945 The novel, recurrent mutation in the TOP2A gene results in the enhanced topoisomerase activity and transcription deregulation in glioblastoma

10.1101/2020.06.17.158477 — cancer biology — Posted on 2021-02-22

946 An R Package for Divergence Analysis of Omics Data

Dinalankara, W.; Ke, Q.; Geman, D.; Marchionni, L.

10.1101/720391 — bioinformatics — Posted on 2021-02-22

947 SEMplMe: A tool for integrating DNA methylation effects in transcription factor binding affinity predictions

Nishizaki, S. S.; Boyle, A. P.

10.1101/2020.08.13.250118 — bioinformatics — Posted on 2021-02-22

948 Protein yield is tunable by synonymous codon changes of translation initiation sites

Bhandari, B. K.; Lim, C. S.; Remus, D. M.; Chen, A.; van Dolleweerd, C.; Gardner, P. P.

10.1101/726752 — bioinformatics — Posted on 2021-02-22

949 A comprehensive and centralized database for exploring omics data in Autoimmune Diseases

Martorell-Marugan, J.; Lopez-Dominguez, R.; Garcia-Moreno, A.; Toro-Dominguez, D.; Villatoro-Garcia, J. A.; Barturen, G.; Martin-Gomez, A.; Troule, K.; Gomez-Lopez, G.; Al-Shahrour, F.; Gonzalez-Rumayor, V.; Pena-Chilet, M.; Dopazo, J.; Saez-Rodriguez, J.; Alarcon-Riquelme, M. E.; Carmona-Saez, P.

10.1101/2020.06.10.144972 — bioinformatics — Posted on 2021-02-22

950 Random access DNA memory in a scalable, archival file storage system

Banal, J. L.; Shepherd, T. R.; Berleant, J. D.; Huang, H.; Reyes, M.; Ackerman, C. M.; Blainey, P.; Bathe, M.

10.1101/2020.02.05.936369 — bioengineering — Posted on 2021-02-22

951 Characterizing gene expression responses to biomechanical strain in an in vitro model of osteoarthritis

Hung, A.; Housman, G.; Briscoe, E.; Cuevas, C.; Gilad, Y.

10.1101/2021.02.22.432314 — genomics — Posted on 2021-02-22

952 Universal constraints on protein evolution in the long-term evolution experiment with Escherichia coli

Maddamsetti, R.

10.1101/2020.11.23.394791 — evolutionary biology — Posted on 2021-02-22

953 Robustness of phylogenetic inference to model misspecification caused by pairwise epistasis

Magee, A. F.; Hilton, S. K.; DeWitt, W. S.

10.1101/2020.11.17.387365 — evolutionary biology — Posted on 2021-02-22

954 Aquatic biodiversity enhances multiple nutritional benefits to humans

Bernhardt, J. R.; O'Connor, M. I.

10.1101/691444 — ecology — Posted on 2021-02-22

955 Multiple PDZ Domain Protein Maintains Patterning of the Apical Cytoskeleton in Sensory Hair Cells

Jarysta, A.; Tarchini, B.

10.1101/2021.02.20.432099 — developmental biology — Posted on 2021-02-22

956 Germline activity of the heat shock factor HSF-1 programs the insulin-receptor daf-2 in C. elegans

Prahlad, V.; Das, S.; Min, S.

10.1101/2021.02.22.432344 — cell biology — Posted on 2021-02-22

957 Mitochondrial F1FO ATP synthase determines the local proton motive force in cristae tips

Rieger, B.; Arroum, T.; Villalta, J.; Busch, K. B.

10.1101/2021.02.11.430746 — cell biology — Posted on 2021-02-22

958 Catabolism of lysosome-related organelles in color-changing spiders supports intracellular turnover of pigments

Figon, F.; Hurbain, I.; Heiligenstein, X.; Trepout, S.; Medjoubi, K.; Somogyi, A.; Delevoye, C.; Raposo, G.; Casas, J.

10.1101/2021.02.22.432296 — cell biology — Posted on 2021-02-22

959 ADF and cofilin-1 collaborate to promote cortical actin flow and the leader bleb-based migration of confined cells

Ullo, M. F.; Logue, J. S.

10.1101/2021.01.11.426289 — cell biology — Posted on 2021-02-22

960 Modeling SARS-CoV-2 infection and its individual differences with ACE2-expressing human iPS cells

Sano, E.; Sakamoto, A.; Mimura, N.; Hirabayashi, A.; Muramoto, Y.; Noda, T.; Yamamoto, T.; Takayama, K.

10.1101/2021.02.22.432218 — cell biology — Posted on 2021-02-22

961 Transmission of pre-XDR and XDR-TB in the Mumbai Metropolitan Region, India

Dreyer, V.; Mandal, A.; Dev, P.; Merker, M.; Barilar, I.; Utpatel, C.; Nilgiriwala, K.; Rodrigues, C.; Crook, D. W.; CRyPTIC Consortium, ; Mistry, N. S.; Niemann, S.

10.1101/2021.02.02.429364 — molecular biology — Posted on 2021-02-22

962 Surfactin stimulated by pectin molecular patterns and root exudates acts as a key driver of Bacillus-plant mutualistic interaction

10.1101/2021.02.22.432335 — microbiology — Posted on 2021-02-22

963 Predicted epitope binding core motifs and common amino acid polymorphisms distinguish protective- from susceptibility-associated HLA alleles in leishmaniasis

de Vrij, N.; Meysman, P.; Gielis, S.; Adriaensen, W.; Laukens, K.; Cuypers, B.

10.1101/2021.02.19.431981 — immunology — Posted on 2021-02-22

964 Monitoring oxidative inflammatory processes in live cells and tissue with Hypocrates, a genetically encoded biosensor for hypochlorite

Kostyuk, A.; Tossounian, M.-A.; Panova, A.; Thauvin, M.; Wahni, K.; Van Molle, I.; Raevskii, R.; Baranov, M.; Vriz, S.; Messens, J.; Bilan, D.; Belousov, V.

10.1101/2021.02.22.432222 — immunology — Posted on 2021-02-22

965 Bovine neutrophils release extracellular traps and cooperate with macrophages in Mycobacterium avium subsp. paratuberculosis clearance in vitro

Ladero-Aunon, I.; Molina, E.; Holder, A.; Kolakowski, J.; Harris, H.; Urkitza, A.; Anguita, J.; Werling, D.; Elguezabal, N.

10.1101/2020.12.30.424791 — immunology — Posted on 2021-02-22

966 Age and Race related changes in Gene Expression during Human PBMC aging

Hu, Y.; Xu, Y.; Mao, L.; Xiang, J.; Lei, W.; Chen, G.

10.1101/2021.02.22.432179 — immunology — Posted on 2021-02-22

967 Sterile Inflammation Alters Neutrophil Kinetics in Mice

Singh, A.; Jothiprakasam, T.; Raghavan, J. V.; Jhunjhunwala, S.

10.1101/2021.02.12.430891 — immunology — Posted on 2021-02-22

968 Heterogeneity and excitability of BRAFV600E-induced tumors is determined by PI3K/mTOR-signaling state and Trp53-loss

Cases-Cunillera, S.; van Loo, K. M. J.; Pitsch, J.; Quatraccioni, A.; Sivalingam, S.; Salomoni, P.; Dietrich, D.; Schoch, S.; Becker, A. J.

10.1101/2021.02.22.432030 — neuroscience — Posted on 2021-02-22

969 Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

Wang, C.; Fan, L.; Zhan, L.; Kodama, L.; Liu, B.; Chin, M. Y.; Li, Y.; Le, D.; Zhou, Y.; Condello, C.; Grinberg, L. T.; Seeley, W. W.; Miller, B. L.; Mok, S.-A.; Gestwicki, J. E.; Gan, L.

10.1101/2021.02.22.432272 — neuroscience — Posted on 2021-02-22

970 A compact spatial map in V2 visual cortex

Long, X.; Deng, B.; Cai, J.; Chen, Z. S.; Zhang, S.-J.

10.1101/2021.02.11.430687 — neuroscience — Posted on 2021-02-22

971 High-Speed, Cortex-Wide Volumetric Recording of Neuroactivity at Cellular Resolution using Light Beads Microscopy

Demas, J.; Manley, J.; Tejera, F.; Kim, H.; Martinez Traub, F.; Chen, B.; Vaziri, A.

10.1101/2021.02.21.432164 — neuroscience — Posted on 2021-02-22

972 Conserved cell-lineage controlled epigenetic regulation in human and mouse glioblastoma stem cells determines functionally distinct subgroups

Lu, X.; Maturi, N. P.; Jarvius, M.; Zhao, L.; Xie, Y.; Tan, E.-J.; Xing, P.; Fryknas, M.; Uhrbom, L.; Chen, X.

10.1101/2021.02.22.431953 — neuroscience — Posted on 2021-02-22

973 Child specific activation in left auditory cortex predicts behavioral performance in inhibition tasks.

van Bijnen, S.; Parkkonen, L.; Parviainen, T.

10.1101/2020.04.30.069906 — neuroscience — Posted on 2021-02-22

974 DNA reconciles morphology and colouration in the drunk blenny genus Scartichthys (Teleostei: Blenniidae) and provides insights into their evolutionary history

Delrieu-Trottin, E.; Hartmann Salvo, H.; Saenz Agudelo, P.; Landaeta, M. F.; Perez-Matus, A.

10.1101/2021.02.22.432327 — zoology — Posted on 2021-02-22

975 De novo homology assessment from landmark data: A workflow to identify and track segmented structures in plant time series images

Hodge, J. G.; Li, Q.; Doust, A.

10.1101/2021.02.21.432162 — plant biology — Posted on 2021-02-22

976 Synergy of chemotherapy and macrophage depletion leads to T cell memory activation and durable triple negative breast cancer regression

Singh, S.; Lee, N.; Bado, I.; Hamor, C.; Zhang, L.; Aguirre, S.; Hu, J.; Shen, Y.; Xu, Y.; Gao, Y.; Pedroza, D.; Zhan, N.; Chen, S.-H.; Wan, Y.-W.; Liu, Z.; Chang, J.; Hollern, D.; Perou, C.; Zhang, X.; Rosen, J. M.

10.1101/2021.02.22.432300 — cancer biology — Posted on 2021-02-22

977 The role of memory in non-genetic inheritance and its impact on cancer treatment resistance

Cassidy, T.; Nichol, D.; Robertson-Tessi, M.; Craig, M.; Anderson, A. R. A.

10.1101/2021.02.22.431869 — cancer biology — Posted on 2021-02-22

978 Tetrameric UvrD helicase is located at the E. coli replisome due to frequent replication blocks

Wollman, A. J.; Syeda, A.; Leech, A.; Guy, C.; McGlynn, P.; Hawkins, M.; Leake, M. C.

10.1101/2021.02.22.432310 — biophysics — Posted on 2021-02-22

979 Previously uncharacterized interactions between the folded and intrinsically disordered domains impart asymmetric effects on UBQLN2 phase separation

Zheng, T.; Castaneda, C. A.

10.1101/2021.02.22.432116 — biophysics — Posted on 2021-02-22

980 Machine Learning Differentiates Enzymatic and Non-Enzymatic Metals in Proteins

Feehan, R.; Franklin, M. W.; Slusky, J. S. G.

10.1101/2021.02.01.429261 — biophysics — Posted on 2021-02-22

981 PharmaNet: Pharmaceutical discovery with deep recurrent neural networks.

Ruiz Puentes, P.; Valderrama, N.; Gonzalez, C.; Daza, L.; Munoz-Camargo, C.; Cruz, J. C.; Arbelaez, P.

10.1101/2020.10.21.348441 — bioinformatics — Posted on 2021-02-22

982 Scalable Bias-corrected Linkage Disequilibrium Estimation Under Genotype Uncertainty

Gerard, D.

10.1101/2021.02.08.430270 — bioinformatics — Posted on 2021-02-22

983 scGRNom: a computational pipeline of integrative multi-omics analyses for predicting cell-type disease genes and regulatory networks

Jin, T.; Rehani, P.; Ying, M.; Huang, J.; Liu, S.; Roussos, P.; Wang, D.

10.1101/2020.06.11.147314 — bioinformatics — Posted on 2021-02-22

984 Experimental evidence for enhanced receptor binding by rapidly spreading SARS-CoV-2 variants

Laffeber, C.; de Koning, K.; Kanaar, R.; Lebbink, J.

10.1101/2021.02.22.432357 — biochemistry — Posted on 2021-02-22

985 The role of interspecies recombinations in the evolution of antibiotic resistant pneumococci

D'Aeth, J. C.; van der Linden, M. P. G.; McGee, L.; De Lencastre, H. C.; Turner, P.; Song, J.-H.; Lo, S. W.; Gladstone, R. A.; Sá-Leão, R.; Ko, K. S.; Hanage, W. P.; Beall, B.; Bentley, S. D.; Croucher, N. J.; The GPS Consortium,

10.1101/2021.02.22.432219 — genomics — Posted on 2021-02-22

986 Outbreeding depression as a selective force on mixed mating in the mangrove rivulus fish, Kryptolebias marmoratus

Gresham, J. D.; Earley, R. L.

10.1101/2021.02.22.432322 — evolutionary biology — Posted on 2021-02-22

987 Reanalysis of deep-sequencing data from Austria points towards a small SARS-COV-2 transmission bottleneck on the order of one to three virions

Martin, M. A.; Koelle, K.

10.1101/2021.02.22.432096 — evolutionary biology — Posted on 2021-02-22

988 A Comprehensive Phylogenomic Platform for Exploring the Angiosperm Tree of Life

Baker, W. J.; Bailey, P.; Barber, V.; Barker, A.; Bellot, S.; Bishop, D.; Botigue, L. R.; Brewer, G.; Carruthers, T.; Clarkson, J. J.; Cook, J.; Cowan, R. S.; Dodsworth, S.; Epitawalage, N.; Francoso, E.; Gallego, B.; Johnson, M.; Kim, J. T.; Leempoel, K.; Maurin, O.; McGinnie, C.; Pokorny, L.; Roy, S.; Stone, M.; Toledo, E.; Wickett, N. J.; Zuntini, A. R.; Eiserhardt, W. L.; Kersey, P. J.; Leitch, I. J.; Forest, F.

10.1101/2021.02.22.431589 — evolutionary biology — Posted on 2021-02-22

989 Sex-specific body mass ageing trajectories in adult Asian elephants

Lalande, L. D.; Lummaa, V.; Aung, H. H.; Htut, W.; Nyein, U. K.; Berger, V.; Briga, M.

10.1101/2020.12.17.423208 — evolutionary biology — Posted on 2021-02-22

990 A G protein-coupled receptor is required in cartilaginous and dense connective tissues to maintain spine alignment

Liu, Z.; Hussien, A. A.; Wang, Y.; Heckman, T.; Gonzalez, R.; Karner, C. M.; Snedeker, J. G.; GRAY, R.

10.1101/2021.02.22.432353 — developmental biology — Posted on 2021-02-22

991 Atg39 selectively captures inner nuclear membrane into lumenal vesicles for delivery to the autophagosome

Chandra, S.; Mannino, P. J.; Thaller, D. J.; Ader, N. R.; King, M. C.; Melia, T.; Lusk, C. P.

10.1101/2021.02.22.432332 — cell biology — Posted on 2021-02-22

992 Resurrection of human endogenous retroviruses during aging reinforces senescence

Liu, X.; Liu, Z.; Sun, L.; Ren, J.; Wu, Z.; Jiang, X.; Ji, Q.; Wang, Q.; Fan, Y.; Cai, Y.; Wang, S.; Li, W.; Cao, G.; Song, M.; Lu, F.; Zhang, W.; Qu, J.; liu, g.

10.1101/2021.02.22.432260 — cell biology — Posted on 2021-02-22

993 Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures

Rausser, S.; Trumpff, C.; McGill, M. A.; Junker, A.; Wang, W.; Ho, S.-H.; Mitchell, A.; Karan, K. R.; Monk, C.; Segerstrom, S. C.; Reed, R. G.; Picard, M.

10.1101/2020.10.16.342923 — cell biology — Posted on 2021-02-22

994 Acquisition of the L452R mutation in the ACE2-binding interface of Spike protein triggers recent massive expansion of SARS-Cov-2 variants

Tchesnokova, V.; Kulakesara, H.; Larson, L.; Bowers, V.; Rechkina, E.; Kisiela, D.; Sledneva, Y.; Choudhury, D.; Maslova, I.; Deng, K.; Kutumbaka, K.; Geng, H.; Fowler, C.; Ralston, J. D.; Greene, D.; Samadpour, M.; Sokurenko, E. V.

10.1101/2021.02.22.432189 — microbiology — Posted on 2021-02-22

995 Sequences in the Human papillomavirus Type 18 (HPV18) Upstream Regulatory Region regulate Viral Genome Replication, Establishment and Persistence

Coursey, T. L.; Van Doorslaer, K.; McBride, A. A.

10.1101/2021.02.22.432334 — microbiology — Posted on 2021-02-22

996 High-Throughput, Single-Copy Sequencing Reveals SARS-CoV-2 Spike Variants Coincident with Mounting Humoral Immunity during Acute COVID-19

Ko, S. H.; Bayat Mokhtari, E.; Mudvari, P.; Stein, S.; Stringham, C. D.; Wagner, D.; Ramelli, S.; Ramirez-Benitez, M. J.; Strich, J. R.; Davey, R. T.; Zhou, T.; Misasi, J.; Kwong, P. D.; Chertow, D. S.; Sullivan, N. J.; Boritz, E. A.

10.1101/2021.02.21.432184 — microbiology — Posted on 2021-02-22

997 Comparative analysis of host-associated variation in Phytophthora cactorum

Nellist, C. F.; Armitage, A. D.; Bates, H. J.; Sobczyk, M. K.; Luberti, M.; Lewis, L. A.; Harrison, R. J.

10.1101/2021.02.22.432166 — microbiology — Posted on 2021-02-22

998 The interspecific fungal hybrid Verticillium longisporum displays sub-genome-specific gene expression

Depotter, J.; van Beveren, F.; Rodriguez-Moreno, L.; Kramer, M.; Chavarro Carrero, E.; Lorencini Fiorin, G.; van den Berg, G.; Wood, T.; Thomma, B.; Seidl, M.

10.1101/341636 — microbiology — Posted on 2021-02-22

999 An Autoantigen Profile of Human A549 Lung Cells Reveals Viral and Host Etiologic Molecular Attributes of Autoimmunity in COVID-19

Wang, J. Y.; Zhang, W.; Roehrl, M. W.; Roehrl, V. B.; Roehrl, M. H.

10.1101/2021.02.21.432171 — immunology — Posted on 2021-02-22

1000 Laser-facilitated epicutaneous immunization with SARS-CoV-2 spike protein induces ACE2 blocking antibodies in mice

Scheiblhofer, S.; Drother, S.; Braun, W.; Braun, R.; Boesch, M.; Weiss, R.

10.1101/2021.02.22.432259 — immunology — Posted on 2021-02-22

1001 Levetiracetam treatment normalizes levels of the presynaptic endocytosis machinery and restores non-amyloidogenic APP processing in App knock-in mice.

Rao, N. R.; Savas, J.

10.1101/2021.02.22.432282 — neuroscience — Posted on 2021-02-22

1002 Ribosomes in RNA granules are stalled on mRNA sequences that are consensus sites for FMRP association.

Anadolu, M. N.; Kailasam, s.; Simbriger, K.; Sun, J.; Markova, T.; Jafarnejad, S. M.; Lefebvre, F.; Ortega, J.; Gkogkas, C. G.; Sossin, W. S.

10.1101/2021.02.22.432349 — neuroscience — Posted on 2021-02-22

1003 Role of 5-HT2C receptors in zebrafish alarm reactions and post-exposure behavior

do Carmo Silva, R. X.; do Nascimento, B. G.; Gomes, G. C. V.; Holanda da Silva, N. A.; Pinheiro, J. S.; da Silva Chaves, S. N.; Pimentel, A. F. N.; Costa, B. P. D.; Herculano, A. M.; Lima-Maximino, M.; Maximino, C.

10.1101/2020.10.04.324202 — neuroscience — Posted on 2021-02-22

1004 Kynurenine pathway in post-mortem prefrontal cortex and cerebellum in schizophrenia: relationship with monoamines and symptomatology.

Afia, A. B.; Vila, E.; MacDowell, K. S.; Ormazabal, A.; Leza, J. C.; Haro, J.; Artuch, R.; Ramos, B.; Garcia-Bueno, B.

10.1101/2021.02.22.432214 — neuroscience — Posted on 2021-02-22

1005 Gradients of receptor expression in the macaque cortex

Froudist-Walsh, S.; Xu, T.; Niu, M.; Rapan, L.; Zilles, K.; Margulies, D. S.; Wang, X.-J.; Palomero-Gallagher, N.

10.1101/2021.02.22.432173 — neuroscience — Posted on 2021-02-22

1006 SARS-CoV-2 B.1.1.7 and B.1.351 Spike variants bind human ACE2 with increased affinity

Khavari, P.; Ramanathan, M.; Ferguson, I. D.; Miao, W.

10.1101/2021.02.22.432359 — pathology — Posted on 2021-02-22

1007 E. coli chemotaxis is information-limited

Mattingly, H. H.; Kamino, K.; Machta, B. B.; Emonet, T.

10.1101/2021.02.22.432091 — biophysics — Posted on 2021-02-22

1008 Nanoceutical Fabric Prevents COVID-19 Spread through Expelled Respiratory Droplets: A Combined Computational, Spectroscopic and Anti-microbial Study

Adhikari, A.; Pal, U.; Bayan, S.; Mondal, S.; Ghosh, R.; Darbar, S.; Saha-Dasgupta, T.; Ray, S. K.; Pal, S. K.

10.1101/2021.02.20.432081 — microbiology — Posted on 2021-02-22

1009 KLF2 is a therapeutic target for COVID-19 induced endothelial dysfunction

Xu, S.; Luo, S.; Zheng, X.; Weng, J.

10.1101/2021.02.20.432085 — pharmacology and toxicology — Posted on 2021-02-22

1010 Estimating DNA methylation potential energy landscapes from nanopore sequencing data

Abante, J.; Kambhampati, S.; Feinberg, A. P.; Goutsias, J.

10.1101/2021.02.22.431480 — bioinformatics — Posted on 2021-02-22

1011 A spindle and thread-mechanism unblocks translation of N-terminally disordered proteins

Kaldmae, M.; Vosselman, T.; Zhong, X.; Lama, D.; Chen, G.; Saluri, M.; Kronqvist, N.; Siau, J. W.; Ng, A. S.; Ghadessy, F. J.; Sabatier, P.; Vojtesek, B.; Sarr, M.; Sahin, C.; Osterlund, N.; Ilag, L. I.; Vaananen, V. A.; Sedimbi, S.; Zubarev, R.; Nilsson, L.; Koeck, P. J.; Rising, A.; Fritz, N.; Johansson, J.; Lane, D. P.; Landreh, M.

10.1101/2021.02.22.432221 — biochemistry — Posted on 2021-02-22

1012 High Throughput Nanopore Sequencing of SARS-CoV-2 Viral Genomes from Patient Samples

Pater, A. A.; Bosmeny, M. S.; Parasrampuria, M.; Eddington, S. B.; Ovington, K. N.; White, A. A.; Barkau, C. L.; Metz, P. E.; Sylvain, R. J.; Chilamkurthy, R.; Yinusa, A. O.; Benzinger, S. W.; Hebert, M. M.; Gagnon, K. T.

10.1101/2021.02.09.430478 — genomics — Posted on 2021-02-22

1013 Small-RNA sequencing reveals altered skeletal muscle microRNAs and snoRNAs signatures in weanling male offspring from mouse dams fed a low protein diet during lactation

Kanakis, I.; Alameddine, M.; Folkes, L.; Moxon, S.; Myrtziou, I.; Ozanne, S. E.; Peffers, M. J.; Goljanek-Whysall, K.; Vasilaki, A.

10.1101/2021.02.22.432208 — molecular biology — Posted on 2021-02-22

1014 Dual proteomics of Drosophila melanogaster hemolymph infected with the heritable endosymbiont Spiroplasma poulsonii

Masson, F.; Rommelaere, S.; Marra, A.; Schupfer, F.; Lemaitre, B.

10.1101/2021.02.22.432267 — microbiology — Posted on 2021-02-22

1015 Engineering protease-resistant peptides to inhibit human parainfluenza viral respiratory infection

Outlaw, V. K.; Cheloha, R. W.; Jurgens, E.; Bovier, F. T.; Zhu, Y.; Kreitler, D. F.; Harder, O. K.; Niewiesk, S.; Porotto, M.; Gellman, S. H.; Moscona, A.

10.1101/2021.02.22.432312 — microbiology — Posted on 2021-02-22

1016 Comparative Perturbation-Based Modeling of the SARS-CoV-2 Spike Protein Binding with Host Receptor and Neutralizing Antibodies : Structurally Adaptable Allosteric Communication Hotspots Define Spike Sites Targeted by Global Circulating Mutations

Verkhivker, G.; Agajanian, S.; Oztas, D. Y.; Gupta, G.

10.1101/2021.02.21.432165 — biophysics — Posted on 2021-02-22

1017 Physically interacting beta-delta pairs in the regenerating pancreas revealed by single cell sequencing

Yanowski, E.; Yacovzada, N. S.; David, E.; Giladi, A.; Jaitin, D.; Farack, L.; Egozi, A.; Ben-Zvi, D.; Itzkovitz, S.; Amit, I.; Hornstein, E.

10.1101/2021.02.22.432216 — cell biology — Posted on 2021-02-22

1018 GABARAP membrane conjugation sequesters the FLCN-FNIP tumor suppressor complex to activate TFEB and lysosomal biogenesis

Goodwin, J.; Walkup, W. G.; Hooper, K.; Li, T.; Kishi-Itakura, C.; Ng, A.; Lehmberg, T.; Jha, A.; Kommineni, S.; Fletcher, K.; Garcia-Fortanet, J.; Fan, Y.; Tang, Q.; Wei, M.; Agrawal, A.; Budhe, S. R.; Rouduri, S. R.; Baird, D.; Saunders, J.; Kiselar, J.; Chance, M. R.; Ballabio, A.; Appleton, B. A.; Brumell, J. H.; Florey, O.; Murphy, L. O.

10.1101/2021.02.22.432209 — cell biology — Posted on 2021-02-22

1019 Fundamental Role Of The H2A.Z C-Terminal Tail In The Formation Of Constitutive Heterochromatin

Imre, L.; Nanasi, P.; Bosire, R.; Csoti, A.; Enyedi, K. N.; Mezo, G.; Kusakabe, M.; Ausio, J.; Harata, M.; Szabo, G.

10.1101/2021.02.22.432230 — cell biology — Posted on 2021-02-22

1020 Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016

Starr, T. N.; Greaney, A. J.; Dingens, A. S.; Bloom, J. D.

10.1101/2021.02.17.431683 — microbiology — Posted on 2021-02-22

1021 A novel glucocorticoid and androgen receptor modulator reduces viral entry and innate immune inflammatory responses in the Syrian Hamster model of SARS-CoV-2

Rocha, S. M.; Fagre, A. C.; Latham, A. S.; Popichak, K. A.; McDermott, C. P.; Dawson, C. C.; Lewis, J.; Reigan, P.; Aboellail, T. A.; Kading, R. C.; Schountz, T.; Theise, N. D.; Slayden, R. A.; Tjalkens, R. B.

10.1101/2021.02.20.432110 — immunology — Posted on 2021-02-22

1022 Reduced binding and neutralization of infection- and vaccine-induced antibodies to the B.1.351 (South African) SARS-CoV-2 variant

Edara, V. V.; Norwood, C.; Floyd, K.; Lai, L.; Davis-Gardner, M. E.; Hudson, W. H.; Mantus, G.; Nyhoff, L. E.; Adelman, M. W.; Fineman, R.; Patel, S.; Byram, R.; Gomes, D. N.; Michael, G.; Abdullahi, H.; Beydoun, N.; Panganiban, B.; McNair, N.; Hellmeister, K.; Pitts, J.; Winters, J.; Kleinhenz, J.; Usher, J.; O'Keefe, J. B.; Piantadosi, A.; Waggoner, J. J.; Babiker, A.; Stephens, D. S.; Anderson, E. J.; Edupuganti, S.; Rouphael, N.; Ahmed, R.; Wrammert, J.; Suthar, M. S.

10.1101/2021.02.20.432046 — immunology — Posted on 2021-02-22

1023 Structural Basis for Accommodation of Emerging B.1.351 and B.1.1.7 Variants by Two Potent SARS-CoV-2 Neutralizing Antibodies

Cerutti, G.; Rapp, M.; Guo, Y.; Bahna, F.; Bimela, J.; Reddem, E. R.; Yu, J.; Wang, P.; Liu, L.; Huang, Y.; Ho, D. D.; Kwong, P. D.; Sheng, Z.; Shapiro, L.

10.1101/2021.02.21.432168 — biochemistry — Posted on 2021-02-22

1024 Old players in new posts: the role of P53, ATM and DNAPK in DNA damage-related ubiquitylation-dependent removal of S2P RNAPII

Borsos, B. N.; Pantazi, V.; Pahi, Z. G.; Majoros, H.; Ujfaludi, Z.; Berzsenyi, I.; Pankotai, T.

10.1101/2021.02.22.432201 — molecular biology — Posted on 2021-02-22

1025 Cardiac Atrial Compartmentalisation Proteomics: A Modified Density Gradient Method to Analyse Endo-lysosomal Proteins

Ayagama, T.; Bose, S. J.; Capel, R. A.; Priestman, D. A.; Berridge, G.; Fisher, R. J.; Galione, A.; Platt, F. M.; Kramer, H.; Burton, R. A. B.

10.1101/2021.02.22.432193 — molecular biology — Posted on 2021-02-22

1026 Statistical testing and annotation of gene transcriptomic-neuroimaging associations

Wei, Y.; de Lange, S. C.; Pijnenburg, R.; Scholtens, L. H.; Ardesch, D. J.; Watanabe, K.; Posthuma, D.; van den Heuvel, M. P.

10.1101/2021.02.22.432228 — neuroscience — Posted on 2021-02-22

1027 Unbiased choice of global clustering parameters in single-molecule localization microscopy

Nold, A.; Sun, C.; Heilemann, M.; Schuman, E.; Tchumatchenko, T.

10.1101/2021.02.22.432198 — bioinformatics — Posted on 2021-02-22

1028 Nano Pom-poms Prepared Highly Specific Extracellular Vesicles Expand the Detectable Cancer Biomarkers

He, M.

10.1101/2021.02.21.432188 — bioengineering — Posted on 2021-02-22

1029 High-level representations in human occipito-temporal cortex are indexed by distal connectivity

Walbrin, J.; Almeida, J.

10.1101/2021.02.22.432202 — neuroscience — Posted on 2021-02-22

1030 Genome-wide transcriptional responses of marine nematode Litoditis marina to hyposaline and hypersaline stresses

Xie, Y.; Zhang, P.; Zhang, L.

10.1101/2021.02.21.432187 — zoology — Posted on 2021-02-22

1031 B/tMSI-CAST: a systematic approach for microsatellite instability detection in both tumor tissue and plasma specimens from next-generation sequencing data

Li, W.; Huang, F.; Huang, J.; YANG, J.; Zhang, H.; Zhao, L.; Xie, H.; Wang, X.; Hong, Y.; Shu, J.; Yu, J.; Li, Q.; Chen, W.; He, J.

10.1101/2021.02.22.432191 — bioinformatics — Posted on 2021-02-22

1032 Recovery of small plasmid sequences via Oxford Nanopore sequencing

Wick, R. R.; Judd, L. M.; Wyres, K. L.; Holt, K. E.

10.1101/2021.02.21.432182 — bioinformatics — Posted on 2021-02-22

1033 Structure-function Specialisation of the Interfascicular Matrix in the Human Achilles Tendon

Patel, D.; Zamboulis, D. E.; Spiesz, E. M.; Simpson, D.; Birch, H. L.; Clegg, P. D.; Thorpe, C. T.; Screen, H. R. C.

10.1101/2021.02.22.432199 — bioengineering — Posted on 2021-02-22

1034 Automatic segmentation and cardiac mechanics analysis of evolving zebrafish using deep-learning

Zhang, B.; Pas, K.; Ijaseun, T.; Cao, H.; Fei, P.; Lee, J.

10.1101/2021.02.21.432186 — bioengineering — Posted on 2021-02-22

1035 Chemical rescue of mutant proteins in living cells by naturally occurring small molecules

Hassell, D. S.; Steingesser, M. G.; Denney, A. S.; Johnson, C. R.; McMurray, M. A.

10.1101/2021.02.21.432174 — genetics — Posted on 2021-02-22

1036 A chimeric nuclease substitutes CRISPR-Cas: A phage weaponizes laterally acquired specificity to destroy subviral parasites

Barth, Z. K.; Nguyen, M. H. T.; Seed, K.

10.1101/2021.02.21.432181 — microbiology — Posted on 2021-02-22

1037 GAT-FD: An Integrated MATLAB Toolbox for Graph Theoretical Analysis of Task-Related Functional Dynamics

Cao, M.; Wu, Z.; Li, X.

10.1101/2021.02.21.432161 — neuroscience — Posted on 2021-02-22

1038 Volumetric Calcium Imaging of 1 Million Neurons Across Cortical Regions at Cellular Resolution Using Light Beads Microscopy

Vaziri, A.; Demas, J.; Manley, J.; Tejera, F.; Barber, K.; Kim, H.; Martinez Traub, F.; Chen, B.

10.1101/2021.02.21.432164 — neuroscience — Posted on 2021-02-22

1039 Dynamic Predictive Coding with Hypernetworks

Jiang, L. P.; Gklezakos, D. C.; Rao, R. P. N.

10.1101/2021.02.22.432194 — neuroscience — Posted on 2021-02-22

1040 Assembly of chromosome-scale and allele-aware autotetraploid genome of the Chinese alfalfa cultivar Zhongmu-4 and identification of SNP loci associated with 27 agronomic traits

Long, R.; Zhang, F.; Zhang, Z.; Li, M.; Chen, L.; Wang, X.; Liu, W.; Zhang, T.; Yu, L.-X.; He, F.; Jiang, X.; Yang, X.; Yang, C.; Wang, Z.; Kang, J.; Yang, Q.

10.1101/2021.02.21.428692 — plant biology — Posted on 2021-02-22

1041 IL-32 is a metabolic regulator promoting survival and proliferation of malignant plasma cells

Aass, K. R.; Mjelle, R.; Kastnes, M. H.; Tryggestad, S. S.; van den Brink, L. M.; Westhrin, M.; Zahoor, M.; Moen, S. H.; Buene, G.; Misund, K.; Sponaas, A.-M.; Ma, Q.; Sundan, A.; Groen, R. W.; Slordahl, T. S.; Waage, A.; Standal, T.

10.1101/2021.02.22.431638 — cancer biology — Posted on 2021-02-22

1042 Illustrating Potential Effects of Alternate Control Populations on Real-World Evidence-based Statistical Analyses

Huang, Y.; Yuan, W.; Kohane, I. S.; Beaulieu-Jones, B.

10.1101/2021.02.21.432172 — bioinformatics — Posted on 2021-02-22

1043 A Framework for Evaluating Myocardial Stiffness Using 3D-Printed Hearts

Kolawole, F. O.; Peirlinck, M.; Cork, T. E.; Wang, V. Y.; Dual, S. S.; Levenston, M. O.; Kuhl, E.; Ennis, D. B.

10.1101/2021.02.21.432169 — bioengineering — Posted on 2021-02-22

1044 The Antiviral Enzyme, Viperin, Activates Protein Ubiquitination by the E3 Ubiquitin Ligase, TRAF6

Patel, A. M.; Marsh, N.

10.1101/2021.02.21.432004 — biochemistry — Posted on 2021-02-22

1045 Rare genera differentiate urban green space soil bacterial communities in three cities across the world

Mills, J. G.; Selway, C. A.; Weyrich, L. S.; Skelly, C.; Weinstein, P.; Thomas, T.; Young, J. M.; Marczylo, E.; Yadav, S.; Yadav, V.; Lowe, A. J.; Breed, M. F.

10.1101/2021.02.21.432167 — ecology — Posted on 2021-02-22

1046 CCM2 deficient endothelial cells undergo a mechano-dependent reprogramming into senescence associated secretory phenotype used to recruit endothelial and immune cells.

Vannier, D. R.; Shapeti, A.; Chuffart, F.; Planus, E.; Manet, S.; Rivier, P.; destaing, o.; Albiges-Rizo, C.; Van Oosterwyck, H.; Faurobert, E.

10.1101/2021.02.22.432204 — cell biology — Posted on 2021-02-22

1047 Nanoscale dynamics of cellulase TrCel7A digesting cellulose

Haviland, Z. K.; Nong, D.; Vasquez Kuntz, K.; Starr, T. J.; Ma, D.; Tien, M.; Anderson, C. T.; Hancock, W. O.

10.1101/2021.02.18.431891 — plant biology — Posted on 2021-02-22

1048 Antiviral effect of a nucleic acid hydrolyzing scFv against oseltamivir resistant influenza A virus

Lee, Y.; Kim, D.; Kim, T.; Oh, Y.; Kim, w.-k.; Lee, S.

10.1101/2021.02.19.432068 — microbiology — Posted on 2021-02-22

1049 NAMPT-derived NAD+ fuels PARP1 to promote skin inflammation through parthanatos

Martinez-Morcillo, F. J.; Canton-Sandoval, J.; Martinez-Navarro, F. J.; cabas, I.; Martinez-Vicente, I.; Armistead, J.; Hatzold, J.; Lopez-Munoz, A.; Martinez-Menchon, T.; Corbalan-Velez, R.; Lacal, J.; Hammerschmidt, M.; Garcia-Borron, J. C.; Garcia-Ayala, A.; Cayuela, M. L.; Perez-Oliva, A. B.; Garcia-Moreno, D.; Mulero, V.

10.1101/2021.02.19.431942 — immunology — Posted on 2021-02-22

1050 The aversive value of pain in human decision-making

Slimani, H.; Rainville, P.; Roy, M.

10.1101/2021.02.19.431988 — neuroscience — Posted on 2021-02-22

1051 BTBD9 is a novel component of IGF signaling and regulates manganese-induced dopaminergic dysfunction

Chen, P.; Zheng, F.; Li, S.; Cheng, H.; Bornhorst, J.; Li, Y.; Yang, B.; Lee, K. H.; Ke, T.; Schwerdtle, T.; Yang, X.; Bowman, A. B.; Aschner, M.

10.1101/2021.02.18.431924 — neuroscience — Posted on 2021-02-22

1052 Time-restricted feeding near dawn entrains long-term behavioral changes through the suprachiasmatic nucleus

Zhai, Q.; Zheng, Y.; Gu, Y.; Zhang, T.; Yuan, B.; Wang, T.; Yan, J.; Qin, H.; Yang, L.; Chen, X.; Vidal-Puig, A.; Xu, Y.

10.1101/2021.02.18.431900 — physiology — Posted on 2021-02-22

1053 Comprehensive Assessment of Somatic Copy Number Variation Calling Using Next-Generation Sequencing Data

Chen, Y.-C.; Seifuddin, F.; Nguyen, C.; Yang, Z.; Chen, W.; Yan, C.; Chen, Q.; Wang, C.; Xiao, W.; Pirooznia, M.; Meerzaman, D.; The Somatic Mutation Working Group of the SEQC-II Consortium,

10.1101/2021.02.18.431906 — bioinformatics — Posted on 2021-02-22

1054 Structural basis of RICs iron donation for iron-sulfur cluster biogenesis

Silva, L.; Matias, P. M.; Romao, C. V.; Saraiva, L. M.

10.1101/2021.02.18.431928 — biochemistry — Posted on 2021-02-22

1055 QTLs for potato tuber resistance to Dickeya solani are located on chromosomes II and IV

Lebecka, R.; Sliwka, J.; Grupa-Urbaska, A.; Szajko, K.; Marczewski, W.

10.1101/2021.02.19.432067 — genetics — Posted on 2021-02-22

1056 Multi-omics reveal intricate network of mitochondrial adaptations to training in human skeletal muscle

Granata, C.; Caruana, N. J.; Botella, J.; Jamnick, N. A.; Huynh, K.; Kuang, J.; Janssen, H. A.; Reljic, B.; Mellett, N. A.; Laskowski, A.; Stait, T. L.; Frazier, A. E.; Coughlan, M. T.; Meikle, P. J.; Thorburn, D. R.; Stroud, D. A.; Bishop, D. J.

10.1101/2021.02.19.431993 — cell biology — Posted on 2021-02-22

1057 Investigating the chemolithoautotrophic and formate metabolism of Nitrospira moscoviensis by constraint-based metabolic modeling and 13C-tracer analysis

Lawson, C. E.; Mundinger, A. B.; Koch, H.; Jacobson, T. B.; Weathersby, C. A.; Jetten, M. S.; Pabst, M.; Amador-Noguez, D.; Noguera, D. R.; McMahon, K.; Lücker, S.

10.1101/2021.02.18.431926 — microbiology — Posted on 2021-02-22

1058 Restoration of BDNF-TrkB signaling rescues deficits in a mouse model of SCA6

Cook, A. A.; Jayabal, S.; Sheng, J.; Fields, E.; Leung, T. C. S.; Quilez, S.; McNicholas, E.; Lau, L.; Watt, A. J.

10.1101/2021.02.21.432180 — neuroscience — Posted on 2021-02-22

1059 Quantitative profiling of axonal guidance proteins during the differentiation of human neurospheres

Goto-Silva, L.; Martins, M.; Murillo, J. R.; Rocha, L.; Vitoria, G.; Oliveira, J. T.; Nascimento, J. M.; Loiola, E. C.; Nogueira, F. C. S.; Domont, G. B.; Guimaraes, M. Z. P.; Tovar-Moll, F.; Rehen, S. K.; Junqueira, M.

10.1101/2021.02.21.432144 — neuroscience — Posted on 2021-02-22

1060 Behavioural synchronization in a multilevel society of feral horses

Maeda, T.; Sueur, C.; Hirata, S.; Yamamoto, S.

10.1101/2021.02.21.432190 — animal behavior and cognition — Posted on 2021-02-22

1061 Precise topology of adjacent domain-general and sensory-biased regions in the human brain

Assem, M.; Shashidhara, S.; Glasser, M. F.; Duncan, J.

10.1101/2021.02.21.431622 — neuroscience — Posted on 2021-02-22

1062 HumGut: A comprehensive Human Gut prokaryotic genomes collection filtered by metagenome data

Hiseni, P.; Rudi, K.; Wilson, R. C.; Hegge, F. T.; Snipen, L.

10.1101/2020.03.25.007666 — microbiology — Posted on 2021-02-22

1063 Sterile Inflammation Alters Neutrophil Kinetics in Mice

Singh, A.; Jothiprakasam, T.; Raghavan, J. V.; Jhunjhunwala, S.

10.1101/2021.02.12.430891 — immunology — Posted on 2021-02-22

1064 Reliability assessment of temporal discounting measures in virtual reality environments

Bruder, L. R.; Scharer, L.; Peters, J.

10.1101/2020.08.07.237826 — neuroscience — Posted on 2021-02-22

1065 Discovering footprints of evolutionary chromatin response to transposons activity: merging biophysics with bioinformatics

Vitali, S.; Giampieri, E.; Sala, C.; Do Valle, I.; Criscione, S.; Neretti, N.; Castellani, G.

10.1101/513572 — biophysics — Posted on 2021-02-22

1066 Playing the piano with a robotic third thumb: Assessing constraints of human augmentation

Shafti, A.; Haar, S.; Mio Zaldivar, R.; Guilleminot, P.; Faisal, A. A.

10.1101/2020.05.21.108407 — neuroscience — Posted on 2021-02-22

1067 Hippocampal sharp wave-ripples and the associated sequence replay emerge from structured synaptic interactions in a network model of area CA3

Ecker, A.; Bagi, B.; Vertes, E.; Steinbach-Nemeth, O.; Karlocai, M. R.; Papp, O. I.; Miklos, I.; Hajos, N.; Freund, T. F.; Gulyas, A. I.; Kali, S.

10.1101/2021.02.18.431868 — neuroscience — Posted on 2021-02-22

1068 Quantifying Viscous Damping and Stiffness in Parkinsonism Using Data-Driven Model Estimation

Werning, A.; Umbarila, D.; Fite, M.; Fergus, S.; Zhang, J.; Molnar, G. F.; Johnson, L. A.; Wang, J.; Vitek, J. L.; Escobar Sanabria, D.

10.1101/2021.02.17.431730 — bioengineering — Posted on 2021-02-22

1069 HybPhaser: a workflow for the detection and phasing of hybrids in target capture datasets

Nauheimer, L.; Weigner, N.; Joyce, E.; Crayn, D.; Clarke, C.; Nargar, K.

10.1101/2020.10.27.354589 — evolutionary biology — Posted on 2021-02-22

1070 Simultaneously monitoring aquatic and riparian biodiversity using riverine water eDNA

YANG, H.; DU, H.; QI, H.; YU, L.; HOU, X.; ZHANG, H.; LI, J.; WU, J.; WANG, C.; ZHOU, Q.; WEI, Q.

10.1101/2020.06.20.162388 — ecology — Posted on 2021-02-22

1071 Motor resonance is modulated by an object's weight distribution

Rens, G.; Orban de Xivry, J.-J.; Davare, M.; van Polanen, V.

10.1101/2020.10.11.335000 — neuroscience — Posted on 2021-02-22

1072 TemplateFlow: a community archive of imaging templates and atlases for improved consistency in neuroimaging

Ciric, R.; Lorenz, R.; Thompson, W. H.; Goncalves, M.; MacNicol, E.; Markiewicz, C.; Halchenko, Y.; Ghosh, S. S.; Gorgolewski, K. J.; Poldrack, R.; Esteban, O.

10.1101/2021.02.10.430678 — neuroscience — Posted on 2021-02-22

1073 Motor and Sensory Cortical Processing of Neural Oscillatory Activities revealed by Human Swallowing using Intracranial Electrodes

Hashimoto, H.; Takahashi, K.; Kameda, S.; Yoshida, F.; Maezawa, H.; Oshino, S.; Tani, N.; Khoo, H. M.; Yanagisawa, T.; Yoshimine, T.; Kishima, H.; Hirata, M.

10.1101/2020.07.21.213868 — neuroscience — Posted on 2021-02-22

1074 Effects of dopamine receptor antagonism and amphetamine-induced psychomotor sensitization on sign- and goal-tracking after extended training

Khoo, S.; Uhrig, A.; Samaha, A.-N.; Chaudhri, N.

10.1101/848150 — neuroscience — Posted on 2021-02-22

1075 Paths to Oblivion: Common Neural Mechanisms of Anaesthesia and Disorders of Consciousness

Luppi, A. I.; Mediano, P. A. M.; Rosas, F. E.; Allanson, J.; Pickard, J. D.; Williams, G. B.; Craig, M. M.; Finoia, P.; Peattie, A. R. D.; Coppola, P.; Owen, A. M.; Naci, L.; Menon, D. K.; Bor, D.; Stamatakis, E. A.

10.1101/2021.02.14.431140 — neuroscience — Posted on 2021-02-22

1076 Low photorespiratory capacity is sufficient to block the induction of photosynthetic capacity in high light

Baker, C. R.; Niyogi, K. K.; Alonso, A. P.; Cocuron, J. C.

10.1101/2021.01.20.427534 — plant biology — Posted on 2021-02-22

1077 Interactions among rooting traits for deep water and nitrogen uptake in upland and lowland ecotypes of switchgrass (Panicum virgatum L.)

Griffiths, M.; Wang, X.; Dhakal, K.; Guo, H.; Seethepalli, A.; Kang, Y.; York, L. M.

10.1101/2021.02.19.432036 — plant biology — Posted on 2021-02-22

1078 Plant trait heterosis is quantitatively associated with expression heterosis of plastid ribosomal proteins

Birdseye, D.; De Boer, L.; Shen, Z.; Bai, H.; Zhou, P.; Schmelz, E. A.; Springer, N. M.; Briggs, S.

10.1101/2021.02.16.431485 — plant biology — Posted on 2021-02-22

1079 Mechanical mapping of mammalian follicle development using Brillouin microscopy

Chan, C.; Bevilacqua, C.; Prevedel, R.

10.1101/2021.02.21.432113 — biophysics — Posted on 2021-02-22

1080 Single cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree

Hendley, A. M.; Rao, A. A.; Leonhardt, L.; Ashe, S.; Smith, J. A.; Giacometti, S.; Peng, X. L.; Jiang, H.; Berrios, D.; Pawlak, M.; Li, L. Y.; Lee, J.; Collisson, E. A.; Anderson, M.; Fragiadakis, G. K.; Yeh, J. J.; Chun, J. Y.; Kim, G. E.; Weaver, V. M.; Hebrok, M.

10.1101/2020.10.12.336784 — bioinformatics — Posted on 2021-02-22

1081 Secondary Structure Motifs Made Searchable to Facilitate the Functional Peptide Design

Tsai, C.-Y.; Salawu, E. O.; Li, H.; Lin, G.-Y.; Kuo, T.-Y.; Voon, L.; Sharma, A.; Hu, K.-D.; Cheng, Y.-Y.; Sahoo, S.; Stuart, L.; Chen, C.-W.; Chang, Y.-Y.; Lu, Y.-L.; Ke, X.; Lan, C.-Y.; Fu, H.-W.; Yang, L.-W.

10.1101/651315 — bioinformatics — Posted on 2021-02-22

1082 Calling small variants with universality and Bayesian-frequentist hybridism

Zhao, X.; Hu, A. C.; Wang, S.; Wang, X.

10.1101/2020.08.23.263749 — bioinformatics — Posted on 2021-02-22

1083 Flexible multivariate linear mixed models for structured multiple traits

Kim, H.; Farage, G.; Lovell, J. T.; Mckay, J. K.; Juenger, T. E.; Sen, S.

10.1101/2020.03.27.012690 — genetics — Posted on 2021-02-22

1084 Epidermal Green Autofluorescence is A Novel Biomarker for Local Inflammation of the Skin

Li, Y.; Ying, W.

10.1101/2021.02.21.432139 — immunology — Posted on 2021-02-21

1085 Insulin-dependent maturation of newly generated olfactory sensory neurons after injury

Kuboki, A.; Kikuta, S.; Otori, N.; Kojima, H.; Matsumoto, I.; Reisert, J.; Yamasoba, T.

10.1101/2021.02.21.432129 — neuroscience — Posted on 2021-02-21

1086 De novo homology assessment from landmark data: A workflow to identify and track segmented structures in plant time series images

Hodge, J. G.; Li, Q.; Doust, A.

10.1101/2021.02.21.432162 — plant biology — Posted on 2021-02-21

1087 FAM114A1 Influences Cardiac Fibrosis by Regulating Angiotensin II Signaling in Cardiac Fibroblasts

Subbaiah, K. C. V.; Wu, J.; Tang, W. W.; Yao, P.

10.1101/2021.02.20.432115 — pathology — Posted on 2021-02-21

1088 Inhibition of SARS-CoV-2 infection in human cardiomyocytes by targeting the Sigma-1 receptor disrupts cytoskeleton architecture and contractility

Salerno, J. A.; Torquato, T.; Temerozo, J. R.; Goto-Silva, L.; Mendes, M. A.; Sacramento, C. Q.; Fintelman-Rodrigues, N.; Vitoria, G.; Souza, L. R. Q.; Ornelas, I. M.; Verissimo, C.; Karmirian, K.; Pedrosa, C. d. S. G.; Dias, S. d. S. G.; Soares, V. C.; Aragao, L. G. H. S.; Puig-Pijuan, T.; Salazar, V. W.; Dariolli, R.; Biagi, D.; Furtado, D. R.; Borges, H. L.; Bozza, P. T.; Guimaraes, M. Z. P.; Souza, T. M. L.; Rehen, S.

10.1101/2021.02.20.432092 — cell biology — Posted on 2021-02-21

1089 TOR complex 2 promotes proteasome dependent Pub1 (NEDD4 family E3 ligase) turnover in fission yeast.

Wang, T.; Woodman, P.; Humphrey, S. J.; Petersen, J.

10.1101/2021.02.21.432158 — cell biology — Posted on 2021-02-21

1090 DpaA detaches Braun's lipoprotein from peptidoglycan

Winkle, M.; Hernandez-Rocamora, V. M.; Pullela, K.; Goodall, E. C. A.; Martorana, A. M.; Gray, J.; Henderson, I. R.; Polissi, A.; Vollmer, W.

10.1101/2021.02.21.432140 — microbiology — Posted on 2021-02-21

1091 Comprehensive survey of microsporidia reveals extensive ecological and phenotypic diversity

Murareanu, B. M.; Sukhdeo, R.; Qu, R.; Jiang, J.; Reinke, A. W.

10.1101/2021.02.21.432160 — microbiology — Posted on 2021-02-21

1092 Structural insight into host plasma membrane association and assembly of HIV-1 Matrix protein

Ciftci, H.; Tateishi, H.; Koiwai, K.; Koga, R.; Anraku, K.; Monde, K.; Dag, C.; Destan, E.; Yuksel, B.; Ayan, E.; Yildirim, G.; Yigin, M.; Ertem, F. B.; Shafiei, A.; Guven, O.; Besler, S. O.; Sierra, R. G.; Yoon, C. H.; Su, Z.; Liang, M.; Acar, B.; Haliloglu, T.; Otsuka, M.; Yumoto, F.; Fujita, M.; Senda, T.; DeMirci, H.

10.1101/2021.02.21.432153 — microbiology — Posted on 2021-02-21

1093 Extracellular Delivery of Functional Mitochondria Reverses the Dysfunction of CD4+ T Cells in Aging

Headley, C. A.; Gautam, S.; Akhter, A.; Dwivedi, V.; Ault, R.; Torrelles, J. B.; Gelfond, J. A. L.; Turner, J.

10.1101/2021.02.21.432151 — immunology — Posted on 2021-02-21

1094 Synchrony of mind and body are distinct in mother-child dyads

Reindl, V.; Wass, S.; Leong, V.; Scharke, W.; Wistuba, S.; Wirth, C. L.; Konrad, K.; Gerloff, C.

10.1101/2021.02.21.432077 — neuroscience — Posted on 2021-02-21

1095 Analysis Of Molecular Networks In The Cerebellum In Chronic Schizophrenia: Modulation By Early Postnatal Life Stressors In Murine Models

Vera-Montecinos, A.; Rodriguez-Mias, R.; MacDowell, K. S.; Garcia-Bueno, B.; Leza, J. C.; Villen, J.; Ramos, B.

10.1101/2021.02.21.432145 — neuroscience — Posted on 2021-02-21

1096 A Transient Metabolic State In Melanoma Persister Cells Mediated By Chemotherapeutic Treatments

Karki, P.; Angardi, V.; Mier, J. C.; Orman, M.

10.1101/2021.02.21.432154 — cancer biology — Posted on 2021-02-21

1097 Investigating crosstalk among PTMs provides novel insight into the structural basis underlying the differential effects of Nt17 PTMs on mutant Httex1 aggregation

Chiki, A.; Zhang, Z.; Rajasekhar, K.; Abriata, L. A.; Rostami, I.; Krapp, L.; Boudeffa, D.; Dal Peraro, M.; Lashuel, H. A.

10.1101/2021.02.21.432155 — biophysics — Posted on 2021-02-21

1098 A cannabinoid receptor agonist shows anti-inflammatory and survival properties in human SARS-CoV-2-infected iPSC-derived cardiomyocytes

Aragao, L. G. H. S.; Oliveira, J. T.; Temerozo, J. R.; Mendes, M. A.; Salerno, J. A.; Pedrosa, C. d. S. G.; Puig-Pijuan, T.; Verissimo, C.; Ornelas, I. M.; Torquato, T.; Vitoria, G.; Sacramento, C. Q.; Fintelman-Rodrigues, N.; Dias, S. d. S. G.; Cardoso Soares, V.; Souza, L. R. Q.; Karmirian, K.; Goto-Silva, L.; Biagi, D.; Cruvinel, E. M.; Dariolli, R.; Furtado, D. R.; Bozza, P. T.; Borges, H. L.; Souza, T. M. L.; Guimaraes, M. Z. P.; Rehen, S.

10.1101/2021.02.20.431855 — cell biology — Posted on 2021-02-21

1099 Dynamic evolution of MLKL in primate and poxvirus genomes indicates necroptosis is a critical, not auxiliary, countermeasure during infection

Palmer, S.; Chappidi, S.; Pinkham, C.; Hancks, D.

10.1101/2021.02.19.432003 — evolutionary biology — Posted on 2021-02-21

1100 Memory destabilization during reconsolidation - A consequence of homeostatic plasticity?

Amorim, F. E.; Chapot, R. L.; Moulin, T. C.; Lee, J. L. C.; Amaral, O. B.

10.1101/2021.02.05.429950 — neuroscience — Posted on 2021-02-21

1101 Unraveling the role of MADS transcription factor complexes in apple tree dormancy using sequential DAP-seq

Falavigna, V. d. S.; Severing, E.; Lai, X.; Estevan, J.; Farrera, I.; Hugouvieux, V.; Zubieta, C.; Coupland, G.; Costes, E.; Andres, F.

10.1101/2021.02.21.431301 — plant biology — Posted on 2021-02-21

1102 Finding Druggable Sites in Proteins using TACTICS

Evans, D. J.; Yovanno, R. A.; Rahman, S.; Cao, D. W.; Beckett, M. Q.; Patel, M. H.; Bandak, A. F.; Lau, A. Y.

10.1101/2021.02.21.432120 — biophysics — Posted on 2021-02-21

1103 GAMIBHEAR: whole-genome haplotype reconstruction from Genome Architecture Mapping data

Markowski, J.; Kempfer, R.; Kukalev, A.; Irastorza-Azcarate, I.; Loof, G.; Kehr, B.; Pombo, A.; Rahmann, S.; Schwarz, R. F.

10.1101/2020.01.30.927061 — bioinformatics — Posted on 2021-02-21

1104 MHC class IIa haplotypes derived by high throughput SNP screening in an isolated sheep population

Dicks, K. L.; Pemberton, J. M.; Ballingall, K. T.; Johnston, S. E.

10.1101/2020.07.20.212225 — evolutionary biology — Posted on 2021-02-21

1105 Causal approach to environmental risks of seabed mining

Kaikkonen, L.; Helle, I.; Kostamo, K.; Kuikka, S.; Nygard, H.; Törnroos, A.; Venesjärvi, R.; Uusitalo, L.

10.1101/2021.02.21.432138 — ecology — Posted on 2021-02-21

1106 Structure-based prediction of KDAC6 substrates validated by enzymatic assay reveals determinants of promiscuity and detects new potential substrates

Varga, J. K.; Diffley, K.; Leng, K. R. W.; Fierke, C. A.; Schueler-Furman, O.

10.1101/2021.02.21.431878 — molecular biology — Posted on 2021-02-21

1107 Multimodal-Neural Predictive Models of Children's General Intelligence That Are Stable Across Two Years of Development

Pornpattananangkul, N.; Wang, Y.; Stringaris, A.

10.1101/2021.02.21.432130 — neuroscience — Posted on 2021-02-21

1108 Adaptive learning through temporal dynamics of state representation

Razmi, N.; Nassar, M. R.

10.1101/2020.08.03.231068 — neuroscience — Posted on 2021-02-21

1109 Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer

Schirmer, A. U.; Driver, L. M.; Zhao, M. T.; Wells, C. I.; Pickett, J. E.; O'Bryne, S. N.; Eduful, B. J.; Yang, X.; Howard, L.; You, S.; Devi, G. R.; Digiovanni, J.; Freedland, S. F.; Chi, J.-T. A.; Drewry, D.; Macias, E.

10.1101/2021.02.21.432137 — cancer biology — Posted on 2021-02-21

1110 Rigid-Body Fitting to Atomic Force Microscopy Images for Inferring Probe Shape and Biomolecular Structure

Niina, T.; Matsunaga, Y.; Takada, S.

10.1101/2021.02.21.432132 — biophysics — Posted on 2021-02-21

1111 Mechanical mapping of mammalian follicle development using Brillouin microscopy

Chan, C.; Prevedel, R.; Bevilacqua, C.

10.1101/2021.02.21.432113 — biophysics — Posted on 2021-02-21

1112 Young and Undamaged rMSA Improves the Longevity of Mice

Tang, J.; Ju, A.; Li, B.; Zhang, S.; Gong, Y.; Ma, B.; Jiang, Y.; Liu, H.; Fu, Y.; Luo, Y.

10.1101/2021.02.21.432135 — biochemistry — Posted on 2021-02-21

1113 Interaural Time Difference Tuning in the Rat Inferior Colliculus is Predictive of Behavioral Sensitivity

Li, K.; Rajendran, V. G.; Mishra, A. P.; Chan, C. H. K.; Schnupp, J. W. H.

10.1101/2021.02.21.432131 — neuroscience — Posted on 2021-02-21

1114 Prediction of nanographene binding-scores to trout cellular receptors and cytochromes

Connolly, M.; Navas, J. M.; Coll, J.

10.1101/2021.02.20.432107 — pharmacology and toxicology — Posted on 2021-02-21

1115 Modulating the properties of DNA-SWCNT sensors using chemically modified DNA

Gillen, A. J.; Lambert, B. P.; Antonucci, A.; Molina-Romero, D.; Boghossian, A. A.

10.1101/2021.02.20.432105 — bioengineering — Posted on 2021-02-21

1116 Ku70 suppresses alternative end-joining in G1-arrested progenitor B cells

Liang, Z.; Kumar, V.; Le Bouteiller, M.; Zurita, J.; Kenrick, J.; Lin, S. G.; Lou, J.; Hu, J.; Ye, A. Y.; Boboila, C.; Alt, F. W.; Frock, R. L.

10.1101/2021.02.20.432121 — genetics — Posted on 2021-02-21

1117 A Ratio-Dependent Model of Replicator-Genetic Parasite Coevolution Demonstrates Instability of the Parasite-Free State

Berezovskaya, F. S.; Karev, G. P.; Wolf, Y. I.; Koonin, E. V.

10.1101/2021.02.20.432109 — evolutionary biology — Posted on 2021-02-21

1118 Intrinsic and growth-mediated cell and matrix specialization during meniscus tissue assembly

Tsinman, T. K.; Jiang, X.; Han, L.; Koyama, E.; Mauck, R. L.; Dyment, N. A.

10.1101/2021.02.20.432114 — developmental biology — Posted on 2021-02-21

1119 A genome-wide circular RNA transcriptome in Rat

Sharma, D.; Sehgal, P.; Sivasubbu, S.; Scaria, V.

10.1101/2021.02.20.432122 — molecular biology — Posted on 2021-02-21

1120 Comparative analysis of 16S rRNA gene and metagenome sequencing in pediatric gut microbiomes

Peterson, D.; Bonham, K. S.; Rowland, S.; Pattanayak, C. W.; RESONANCE Consortium, ; Klepac-Ceraj, V.

10.1101/2021.02.20.432118 — microbiology — Posted on 2021-02-21

1121 Microstates and power envelope hidden Markov modeling probe bursting brain activity at different timescales

Coquelet, N.; De Tiege, X.; Roshchupkina, L.; Peigneux, P.; Goldman, S.; Woolrich, M. W.; Wens, V.

10.1101/2021.02.20.432128 — neuroscience — Posted on 2021-02-21

1122 Condensates in RNA Repeat Sequences are Heterogeneously Organized and Exhibit Reptation-like Dynamics

Nguyen, H.; Hori, N.; Thirumalai, D.

10.1101/2021.02.20.432119 — biophysics — Posted on 2021-02-21

1123 Pathogen community composition and co-infection patterns in a wild community of rodents

Abbate, J. L.; Galan, M.; Razzauti, M.; Sironen, T.; Voutilainen, L.; Henttonen, H.; Gasqui, P.; Cosson, J.-F.; Charbonnel, N.

10.1101/2020.02.09.940494 — ecology — Posted on 2021-02-21

1124 STAG proteins promote cohesin ring loading at R-loops.

Porter, H.; Li, Y.; Varsally, W.; Neguembor, M. V.; Beltran, M.; Pezic, D.; Martin, L.; Tavares Cornejo, M.; Bhamra, A.; Surinova, S.; Jenner, R. G.; Cosma, M. P.; HADJUR, S.

10.1101/2021.02.20.432055 — cell biology — Posted on 2021-02-21

1125 Architecture and assembly dynamics of the essential mitochondrial TIM chaperone systems

Weinhäupl, K.; Wang, Y.; Hessel, A.; Brennich, M.; Lindorff-Larsen, K.; Schanda, P.

10.1101/2020.03.13.990150 — biophysics — Posted on 2021-02-21

1126 Kinesin-3 and kinesin-1 motors direct basement membrane protein secretion to a basal sub-region of the basolateral plasma membrane in epithelial cells

Zajac, A. L.; Horne-Badovinac, S.

10.1101/2021.01.31.429062 — cell biology — Posted on 2021-02-21

1127 Notch-Jagged signaling complex defined by an interaction mosaic

Zeronian, M. R.; Klykov, O.; Portell i de Montserrat, J.; Konijnenberg, M. J.; Gaur, A.; Scheltema, R. A.; Janssen, B. J. C.

10.1101/2021.02.19.432005 — molecular biology — Posted on 2021-02-21

1128 Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociability

Li, L.-F.; Zhang, L.-Z.; He, Z.-X.; Zhang, Y.-T.; Yuan, W.; Ma, H.; Xun, Y.-F.; Hou, W.-J.; Li, Y.-T.; Lv, Z.-J.; Jia, R.; Tai, F.

10.1101/2020.09.21.307280 — neuroscience — Posted on 2021-02-20

1129 Widespread cryptic variation in genetic architecture between the sexes

van der Bijl, W.; Mank, J. E.

10.1101/2021.02.20.432102 — evolutionary biology — Posted on 2021-02-20

1130 Stabilizing role of seed banks and the maintenance of bacterial diversity

Wisnoski, N. I.; Lennon, J. T.

10.1101/2020.10.05.327387 — ecology — Posted on 2021-02-20

1131 Screening by deep sequencing reveals mediators of miRNA tailing in C. elegans

Prothro, K. P.; Vieux, K.-F.; Palmer, C.; Veksler-Lublinsky, I. I.; McJunkin, K.

10.1101/2021.01.11.426275 — molecular biology — Posted on 2021-02-20

1132 DNA-Encoded Multivalent Display of Protein Tetramers on Phage: Synthesis and In Vivo Aplications

Lima, G. M.; Atrazhev, A.; Sarkar, S.; Sojitra, M.; Reddy, R.; Macauley, M. S.; Monteiro, G.; Derda, R.

10.1101/2021.02.20.432100 — molecular biology — Posted on 2021-02-20

1133 LayNii: A software suite for layer-fMRI.

Huber, L.; Poser, B. A.; Bandettini, P. A.; Arora, K.; Wagstyl, K.; Cho, S.; Goense, J.; Nothnagel, N.; Morgan, A. T.; Mueller, A. K.; van den Hurk, J.; Reynolds, R. C.; Glen, D. R.; Goebel, R. W.; Gulban, O. F.

10.1101/2020.06.12.148080 — neuroscience — Posted on 2021-02-20

1134 Predictive Coding Models for Pain Perception

Song, Y.; Yao, M.; Kemprecos, H.; byrne, a.; Xiao, Z.; Zhang, Q.; Singh, A.; Wang, J.; Chen, Z. S.

10.1101/843284 — neuroscience — Posted on 2021-02-20

1135 Reversible fronto-occipitotemporal signaling complements task encoding and switching under ambiguous cues

Tsumura, K.; Kosugi, K.; Hattori, Y.; Aoki, R.; Takeda, M.; Chikazoe, J.; Nakahara, K.; Jimura, K.

10.1101/2020.07.29.227736 — neuroscience — Posted on 2021-02-20

1136 Sunday driver mediates multi-compartment Golgi outposts defects induced by amyloid precursor protein

Du, Q.; Chang, J.; Cheng, G.; Zhao, Y.; Zhou, W.

10.1101/2020.09.02.280321 — neuroscience — Posted on 2021-02-20

1137 A Multiscale Multicellular Spatiotemporal Model of Local Influenza Infection and Immune Response

Sego, T. J.; Mochan, E. D.; Ermentrout, B.; Glazier, J. A.

10.1101/2021.02.20.432089 — systems biology — Posted on 2021-02-20

1138 Functional Near Infrared Spectroscopy (fNIRS) based Odor Detection and Classification using Functional Data Analysis

Moradi, F.; Pourrezaei, K.

10.1101/2021.02.13.431051 — bioinformatics — Posted on 2021-02-20

1139 Reconciling Conformational Heterogeneity and Substrate Recognition in Cytochrome P450

Dandekar, B. R.; Ahalawat, N.; Mondal, J.

10.1101/2020.06.08.139790 — biochemistry — Posted on 2021-02-20

1140 Genetic Association Study of Childhood Aggression across raters, instruments and age

Ip, H. F.; van der Laan, C. M.; Krapohl, E. M. L.; Brikell, I.; Sanchez-Mora, C.; Nolte, I. M.; St Pourcain, B.; Bolhuis, K.; Palviainen, T.; Zafarmand, H.; Colodro-Conde, L.; Gordon, S.; Zayats, T.; Aliev, F.; Jiang, C.; Wang, C. A.; Saunders, G.; Karhunen, V.; Hammerschlag, A. R.; Adkins, D. E.; Border, R.; Peterson, R. E.; Prinz, J. A.; Thiering, E.; Seppälä, I.; Vilor-Tejedor, N.; Ahluwalia, T. S.; Day, F. R.; Hottenga, J.-J.; Allegrini, A. G.; Rimfeld, K.; Chen, Q.; Lu, Y.; Martin, J.; Soler Artigas, M.; Rovira, P.; Bosch, R.; Espanol, G.; Ramos Quiroga, J. A.; Neumann, A.; Ensink, J.;

10.1101/854927 — genomics — Posted on 2021-02-20

1141 Target enrichment and extensive population sampling help untangle the recent, rapid radiation of Oenothera sect. Calylophus

Cooper, B. J.; Moore, M. J.; Douglas, N. A.; Wagner, W. L.; Johnson, M. G.; Overson, R. P.; McDonnell, A. J.; Fant, J. B.; Skogen, K. A.; Wickett, N. J.

10.1101/2021.02.20.432097 — evolutionary biology — Posted on 2021-02-20

1142 Antigenic waves of virus-immune co-evolution

Marchi, J.; Laessig, M.; Walczak, A. M.; Mora, T.

10.1101/2021.02.20.432103 — evolutionary biology — Posted on 2021-02-20

1143 Deep ancestral introgression shapes evolutionary history of dragonflies and damselflies

Suvorov, A.; Scornavacca, C.; Fujimoto, M. S.; Bodily, P.; Clement, M.; Crandall, K. A.; Whiting, M. F.; Schrider, D. R.; Bybee, S. M.

10.1101/2020.06.25.172619 — evolutionary biology — Posted on 2021-02-20

1144 Metabolic depression in sea urchin barrens associated with food deprivation

Spindel, N. B.; Lee, L. C.; Okamoto, D.

10.1101/2020.11.28.402156 — ecology — Posted on 2021-02-20

1145 Representative diatom and coccolithophore species exhibit divergent responses throughout simulated upwelling cycles

Lampe, R. H.; Hernandez, G.; Lin, Y. Y.; Marchetti, A.

10.1101/2020.04.30.071480 — ecology — Posted on 2021-02-20

1146 Quadratic Mutual Information estimation of mouse dLGN receptive fields reveals asymmetry between ON and OFF visual pathways

Mu, Z.; Nikolic, K.; Schultz, S. R.

10.1101/2020.12.03.409342 — neuroscience — Posted on 2021-02-20

1147 A Behavioral Association Between Prediction Errors and Risk-Seeking: Theory and Evidence

Moeller, M.; Grohn, J.; Manohar, S. G.; Bogacz, R.

10.1101/2020.04.29.067751 — neuroscience — Posted on 2021-02-20

1148 Improving stroke detection via Correlation Tensor MRI

Alves, R.; Henriques, R. N.; Kerkela, L.; Chavarrias, C.; Jespersen, S.; Shemesh, N.

10.1101/2021.02.20.432088 — neuroscience — Posted on 2021-02-20

1149 The structural connectome constrains fast brain dynamics

Sorrentino, P.; Seguin, C.; Rucco, R.; Liparoti, M.; Troisi Lopez, E.; Bonavita, S.; Quarantelli, M.; Sorrentino, G.; Jirsa, V.; Zalesky, A.

10.1101/2020.11.25.393017 — neuroscience — Posted on 2021-02-20

1150 Preprints in motion: tracking changes between posting and journal publication

Polka, J. K.; Dey, G.; Palfy, M.; Nanni, F.; Brierley, L.; Fraser, N.; Coates, J. A.

10.1101/2021.02.20.432090 — scientific communication and education — Posted on 2021-02-20

1151 High Light and High Temperature Reduce Photosynthesis via Different Mechanisms in the C4 Model Setaria viridis

Anderson, C. M.; Mattoon, E. M.; Zhang, N.; Becker, E.; McHargue, W.; Yang, J.; Patel, D.; Dautermann, O.; McAdam, S. A. M.; Tarin, T.; Pathak, S.; Avenson, T. J.; Berry, J.; Braud, M.; Niyogi, K. K.; Wilson, M.; Nusinow, D. A.; Vargas, R.; Czymmek, K. J.; Eveland, A. L.; Zhang, R.

10.1101/2021.02.20.431694 — plant biology — Posted on 2021-02-20

1152 quincunx: an R package to query, download and wrangle PGS Catalog data

Magno, R.; Duarte, I.; Maia, A.-T.

10.1101/2021.02.19.431997 — bioinformatics — Posted on 2021-02-20

1153 Distinguishing dopamine and calcium responses using XNA-nanotube sensors for improved neurochemical sensing

Gillen, A. J.; Antonucci, A.; Reggente, M.; Morales, D.; Boghossian, A. A.

10.1101/2021.02.20.428669 — bioengineering — Posted on 2021-02-20

1154 Waves of sumoylation support transcription dynamics during adipocyte differentiation

Zhao, X.; Hendriks, I. A.; Le Gras, s.; Ye, T.; Nguea P, A.; Flor Lien, G.; Ramos-Alonso, L.; Klungland, A.; Jost, B.; Enserink, J. M.; Nielsen, M. L.; Chymkowitch, P.

10.1101/2021.02.20.432084 — genomics — Posted on 2021-02-20

1155 RNA-binding proteins regulate aldosterone homeostasis in human steroidogenic cells

Fu, R.; Wellman, K.; Baldwin, A.; Rege, J.; Walters, K.; Hirsekorn, A.; Riemondy, K.; Rainey, W. E.; Mukherjee, N.

10.1101/2021.02.19.431050 — genomics — Posted on 2021-02-20

1156 Oxford Nanopore sequencing-based protocol to detectCpG methylation in human mitochondrial DNA

Bicci, I.; Calabrese, C.; Golder, Z. J.; Gomez-Duran, A.; Chinnery, P. F.

10.1101/2021.02.20.432086 — genomics — Posted on 2021-02-20

1157 Determining the pathogenicity of MUT gene variant by mini-gene splicing assay

Wang, Y.

10.1101/2021.02.19.432054 — genetics — Posted on 2021-02-20

1158 A conserved paint box underlies color pattern diversity in Estrildid finches

Hidalgo, M.; Curantz, C.; Quenech'Du, N.; Gluckman, T.-L.; Neguer, J.; Beck, S.; Mohammad, A.; Manceau, M.

10.1101/2021.02.19.431992 — developmental biology — Posted on 2021-02-20

1159 Unique functions for Notch4 in murine embryonic lymphangiogenesis

Muley, A.; Kim Uh, M.; James, J. M.; Murtomaki, A.; McCarron, J. D.; Kitajewski, C.; Gnarra, M.; Riitano, G.; Mukouyama, Y.-s.; Kitajewski, J.; Shawber, C. J.

10.1101/2021.02.19.431982 — developmental biology — Posted on 2021-02-20

1160 Early embryogenesis and organogenesis in the annelid Owenia fusiformis

Carrillo-Baltodano, A. M.; Seudre, O.; Guynes, K.; Martin-Duran, J. M.

10.1101/2021.02.20.431505 — developmental biology — Posted on 2021-02-20

1161 Multiple PDZ Domain Protein Maintains Patterning of the Apical Cytoskeleton in Sensory Hair Cells

Jarysta, A.; Tarchini, B.

10.1101/2021.02.20.432099 — developmental biology — Posted on 2021-02-20

1162 STAG proteins promote cohesin ring loading at R-loops.

HADJUR, S.; Porter, H.; Li, Y.; Varsally, W.; Neguembor, M. V.; Beltran, M.; Pezic, D.; Martin, L.; Tavares Cornejo, M.; Bhamra, A.; Surinova, S.; Jenner, R. G.; Cosma, M.

10.1101/2021.02.20.432055 — cell biology — Posted on 2021-02-20

1163 Predicted epitope binding core motifs and common amino acid polymorphisms distinguish protective- from susceptibility-associated HLA alleles in leishmaniasis

de Vrij, N.; Meysman, P.; Gielis, S.; Adriaensen, W.; Laukens, K.; Cuypers, B.

10.1101/2021.02.19.431981 — immunology — Posted on 2021-02-20

1164 Daily orexinergic modulation of the rat superficial layers of the superior colliculus - implications for intrinsic clock activities in the visual system

Chrobok, L.; Jeczmien-Lazur, J. S.; Bubka, M.; Pradel, K.; Klekocinska, A.; Klich, J. D.; Ridla Rahim, A.; Myung, J.; Kepczynski, M.; Lewandowski, M. H.

10.1101/2021.02.20.432093 — neuroscience — Posted on 2021-02-20

1165 Behavioral deficits, learning impairment, and enhanced hippocampal excitability in co-isogenic PrnpZH3/ZH3 mice

Matamoros-Angles, A.; Hervera, A.; Soriano, J.; Marti, E.; Carulla, P.; LLorens, F.; Nuvolone, M.; Aguzzi, A.; Ferrer, I.; Gruart, A.; Delgado-Garcia, J. M.; del Rio, J. A.

10.1101/2021.02.20.432083 — neuroscience — Posted on 2021-02-20

1166 A neural circuit basis for bilateral olfactory input-enhanced chemosensory avoidance navigation

Sy, S. K. H.; Chan, D. C. W.; Lai, H.-M.; Li, Z.; Wong, K. K. Y.; Choi, C. H. J.; Mok, V. C. T.; Hu, Y.; Ko, H.

10.1101/2021.02.20.431946 — neuroscience — Posted on 2021-02-20

1167 Losartan Increases Survival of the Fbn1mgR/mgR Mouse Model of Marfan Syndrome in and Age-Dependent Manner

Smith, J. D.; Chen, J. Z.; Phillip, R.; Daugherty, A.; Sheppard, M. B.

10.1101/2021.02.19.429438 — physiology — Posted on 2021-02-20

1168 KLF2 is a therapeutic target for COVID-19 induced endothelial dysfunction

Xu, S.; Luo, S.; Zheng, X.; Weng, J.

10.1101/2021.02.20.432085 — pharmacology and toxicology — Posted on 2021-02-20

1169 Kinetic Interval Measurement: A Tool to Characterize Thermal Reversion Dynamics of Light-switchable Fluorescent Proteins

von Trotha, T.; Johr, R.; Fischer, J.; Schendel, L. C.; Gaub, H. E.; Kluger, C.

10.1101/2021.02.20.432101 — biophysics — Posted on 2021-02-20

1170 CheSPI: Chemical shift Secondary structure Population Inference

Nielsen, J. T.; Mulder, F. A.

10.1101/2021.02.20.432095 — biochemistry — Posted on 2021-02-20

1171 The Size of the Stag Determines the Level of Cooperation

Schnell, E.; Schimmelpfennig, R.; Muthukrishna, M.

10.1101/2021.02.19.432029 — evolutionary biology — Posted on 2021-02-20

1172 Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19

Ziegler, C. G. K.; Miao, V. N.; Owings, A. H.; Navia, A. W.; Tang, Y.; Bromley, J. D.; Lotfy, P.; Sloan, M.; Laird, H.; Williams, H. B.; George, M.; Drake, R. S.; Christian, T.; Parker, A.; Sindel, C. B.; Burger, M. W.; Pride, Y.; Hasan, M.; Abraham, G. E.; Senitko, M.; Robinson, T. O.; Shalek, A. K.; Glover, S. C.; Horwitz, B. H.; Ordovas-Montanes, J.

10.1101/2021.02.20.431155 — immunology — Posted on 2021-02-20

1173 Interacting brains revisited: A cross-brain network neuroscience perspective

Gerloff, C.; Konrad, K.; Bzdok, D.; Büsing, C.; Reindl, V.

10.1101/2021.02.20.432051 — neuroscience — Posted on 2021-02-20

1174 VAMP2 AND SYNAPTOTAGMINS ARE RELATIVELY IMMOBILE ON CHROMAFFIN GRANULE MEMBRANES: IMPLICATIONS FOR MEMBRANE FUSION AND FUSION PORE EXPANSION

Abbineni, P. S.; Briguglio, J. S.; Chapman, E. R.; Holz, R. W.; Axelrod, D.

10.1101/2021.02.20.432015 — biophysics — Posted on 2021-02-20

1175 Biochemical Methane Potential (BMP) from sugarcane biorefinery residues: maximizing their use by co-digestion

Volpi, M. P. C.; de Paiva, L. B. B.; Mockaitis, G.; Rabelo, S. C.; Franco, T. T.; Moraes, B. d. S.

10.1101/2021.02.19.432018 — bioengineering — Posted on 2021-02-20

1176 Relevance of network topology for the dynamics of biological neuronal networks

Mengiste, S.; Aertsen, A.; Kumar, A.

10.1101/2021.02.19.431963 — neuroscience — Posted on 2021-02-20

1177 Harnessing the Power of Antibodies to Fight Bone Metastasis

Tian, Z.; Wu, L.; Yu, C.; Chen, Y.; Xu, Z.; Bado, I.; Loredo, A.; Wang, L.; Wang, H.; Wu, K.-l.; Zhang, W.; Zhang, X.; Xiao, H.

10.1101/2021.02.19.432037 — cancer biology — Posted on 2021-02-20

1178 Selective stimulation of the ferret abdominal vagus nerve with multi-contact nerve cuff electrodes

Shulgach, J. A.; Beam, D. W.; Nanivadekar, A. C.; Miller, D. M.; Fulton, S.; Sciullo, M.; Ogren, J.; Wong, L.; McLaughlin, B.; Yates, B. J.; Horn, C.; Fisher, L.

10.1101/2021.02.19.431879 — bioengineering — Posted on 2021-02-20

1179 Genomic and Spectral Visual Adaptation in Southern Leopard Frogs during the Ontogenetic Transition from Aquatic to Terrestrial Light Environments

Schott, R. K.; Bell, R. C.; Loew, E. R.; Thomas, K. N.; Gower, D. J.; Streicher, J. W.; Fujita, M. K.

10.1101/2021.02.19.432049 — genomics — Posted on 2021-02-20

1180 Genome-wide association study reveals an independent genetic basis of zinc and cadmium concentrations in fresh sweet corn kernels

Baseggio, M.; Murray, M.; Wu, D.; Ziegler, G.; Kaczmar, N.; Chamness, J.; Hamilton, J. P.; Buell, C. R.; Vatamaniuk, O. K.; Buckler, E. S.; Smith, M. E.; Baxter, I.; Tracy, W. F.; Gore, M. A.

10.1101/2021.02.19.432009 — genetics — Posted on 2021-02-20

1181 The Size of the Stag Determines the Level of Cooperation

Schnell, E.; Schimmelpfennig, R.; Muthukrishna, M.

10.1101/2021.02.19.432029 — evolutionary biology — Posted on 2021-02-20

1182 Environmental DNA in a Global Biodiversity Hotspot: Lessons from Coral Reef Fish Diversity Across the Indonesian Archipelago

Marwayana, O. N.; Gold, Z.; Barber, P. H.

10.1101/2021.02.19.432056 — ecology — Posted on 2021-02-20

1183 Complex response of beta diversity to dispersal in meta-community models

Lu, M.

10.1101/2021.02.19.432043 — ecology — Posted on 2021-02-20

1184 Direct tissue sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients

Amaral-Silva, D.; Torrao, R. C.; Torres, R.; Falcao, S.; Goncalves, M. J.; Araujo, M. P.; Martins, M. J.; Lopes, C.; Neto, A.; Marona, J.; Costa, T.; Castelao, W.; Silva, A. B.; Silva, I.; Lourenco, M. H.; Mateus, M.; Pina Goncalves, N.; Manica, S.; Costa, M.; Pimentel-Santos, F.; Mourao, A. F.; Branco, J. C.; Soares, H.

10.1101/2021.02.19.431679 — immunology — Posted on 2021-02-20

1185 Precision Diffusion Imaging

Seider, N. A.; Adeyemo, B.; Miller, R.; Newbold, D. J.; Hampton, J. M.; Scheidter, K. M.; Rutlin, J.; Laumann, T. O.; Roland, J. L.; Montez, D. F.; Van, A. N.; Zheng, A.; Marek, S.; Kay, B. P.; Bretthorst, G. L.; Schlaggar, B. L.; Greene, D. J.; Wang, Y.; Petersen, S. E.; Gordon, E. M.; Snyder, A. Z.; Shimony, J. S.; Dosenbach, N. U.

10.1101/2021.02.19.432023 — neuroscience — Posted on 2021-02-20

1186 Long-term association of pregnancy and maternal brain structure: the Rotterdam Study

Aleknaviciute, J.; Evans, T.; Aribas, E.; de Vries, M. W.; Steegers, E. A. P.; Ikram, M. A.; Tiemeier, H.; Kavousi, M.; Vernooij, M. W.; Kushner, S. A.

10.1101/2021.02.19.432038 — neuroscience — Posted on 2021-02-20

1187 Interactions among rooting traits for deep water and nitrogen uptake in upland and lowland ecotypes of switchgrass (Panicum virgatum L.)

Griffiths, M.; Wang, X.; Dhakal, K.; Guo, H.; Seethepalli, A.; Kang, Y.; York, L. M.

10.1101/2021.02.19.432036 — plant biology — Posted on 2021-02-20

1188 Four large indels detected by cpTILLING in barley chloroplast mutator seedlings

Lencina, F.; Landau, A.; Pacheco, M. G.; Kobayashi, K.; Prina, A. R.

10.1101/2021.02.19.432034 — plant biology — Posted on 2021-02-20

1189 Actinidia seed-born latent virus is transmitted paternally and maternally at high rates

Amponsah, N. T.; van den Brink, R.; Datson, P. M.; Austin, P. T.; Horner, M.; MacDiarmid, R. M.

10.1101/2021.02.19.432071 — pathology — Posted on 2021-02-20

1190 High levels of truncated RHAMM cooperate with dysfunctional p53 to accelerate theprogression of pancreatic cancer

Feng, J.; Lin, A.; Chen, X.; Wang, D.; Wong, M.; Zhang, G.; Na, J.; Zhang, T.; Chen, Z.; Chen, Y.-T.; Du, Y.-C. N.

10.1101/2021.02.19.432042 — cancer biology — Posted on 2021-02-20

1191 Effect of membrane cholesterol on dynamical properties of solvent molecules

Rahmaninejad, H.; Vaughan, D.

10.1101/2021.02.19.432063 — biophysics — Posted on 2021-02-20

1192 Squidpy: a scalable framework for spatial single cell analysis

Palla, G.; Spitzer, H.; Klein, M.; Fischer, D. S.; Schaar, A. C.; Kuemmerle, L. B.; Rybakov, S.; Ibarra, I. L.; Holmberg, O.; Virshup, I.; Lotfollahi, M.; Richter, S.; Theis, F. J.

10.1101/2021.02.19.431994 — bioinformatics — Posted on 2021-02-20

1193 Competitive coordination of the dual roles of the Hedgehog co-receptor in homophilic adhesion and signal reception

Yang, S.; Zhang, Y.; Yang, C.; Wu, X.; El Oud, S. M.; Chen, R.; Cai, X.; Wu, X.; Lan, G.; Zheng, X.

10.1101/2021.02.19.432013 — bioinformatics — Posted on 2021-02-20

1194 mRNA codon optimization on quantum computers

Fox, D. M.; Branson, K. M.; Walker, R. C.

10.1101/2021.02.19.431999 — bioinformatics — Posted on 2021-02-20

1195 Zooming into the genomic vicinity of the major locus for vicine and convicine in faba bean (Vicia faba L.)

Tacke, R.; Ecke, W.; Hoefer, M.; Sass, O.; Link, W.

10.1101/2021.02.19.431996 — genetics — Posted on 2021-02-20

1196 No evidence for short-term evolutionary response to a warming environment in Drosophila

Santos, M. A.; Carromeu-Santos, A.; Quina, A. S.; Santos, M.; Matos, M.; Simoes, P.

10.1101/2021.02.19.432014 — evolutionary biology — Posted on 2021-02-20

1197 Evaluating how lethal management affects poaching of Mexican wolves

Louchouarn, N. X.; Santiago-Avila, F. J.; Parsons, D. R.; Treves, A.

10.1101/2021.02.19.432027 — ecology — Posted on 2021-02-20

1198 Circulating Low Density Neutrophils of Breast Cancer Patients are Associated with their Worse Prognosis due to the Impairment of T cell Responses

Saraiva, D. P.; Correia, B. F.; Salvador, R.; de Sousa, N.; Jacinto, A.; Braga, S.; Cabral, M. G.

10.1101/2021.02.19.431986 — immunology — Posted on 2021-02-20

1199 Optimizing EEG source reconstruction with concurrent fMRI-derived spatial priors

Abreu, R.; Soares, J. F.; Batista, S.; Lima, A. C.; Sousa, L.; Castelo-Branco, M.; Duarte, J. V.

10.1101/2021.02.19.431976 — neuroscience — Posted on 2021-02-20

1200 Juvenile Huntington's Disease and Other PolyQ diseases, Update on Neurodevelopmental Character and Comparative Bioinformatic Review of Transcriptomic Data

Switonska-Kurkowska, K.; Krist, B.; Delimata, J. M.; Figiel, M.

10.1101/2021.02.19.431958 — neuroscience — Posted on 2021-02-20

1201 Fibroblasts - the neglected cell type in peripheral sensitization and chronic pain? - A systematic view on the current state of the literature.

Shinotsuka, N.; Denk, F.

10.1101/2021.02.19.431978 — neuroscience — Posted on 2021-02-20

1202 Dynamic Electrode-to-Image (DETI) Mapping Reveals the Human Brain's Spatiotemporal Code of Visual Information

Hansen, B. C.; Greene, M. R.; Field, D. J.

10.1101/2021.02.19.431983 — neuroscience — Posted on 2021-02-20

1203 Individual variation in brain microstructural-cognition relationships in aging

Patel, R.; Mackay, C. E.; Jansen, M. G.; Devenyi, G.; O'Donoghue, M. C.; Kivimäki, M.; Singh-Manoux, A.; Zsoldos, E.; Ebmeier, K. P.; Chakravarty, M.; Suri, S.

10.1101/2021.02.19.431732 — neuroscience — Posted on 2021-02-20

1204 A photoswitchable GPCR-based opsin for presynaptic silencing

Copits, B. A.; O'Neill, P. R.; Gowrishankar, R.; Yoo, J. J.; Meshik, X.; Parker, K. E.; Spangler, S. M.; Vasquez, A. M.; Elerding, A. J.; Stander, M. C.; Kalyanaraman, V.; Vogt, S. K.; Samineni, V. K.; Gautam, N.; Sunahara, R. K.; Gereau, R. W.; Bruchas, M. R.

10.1101/2021.02.19.432008 — neuroscience — Posted on 2021-02-20

1205 Rice NIN-LIKE PROTEIN 3 plays a significant role in nitrogen use efficiency and grain yield under nitrate-sufficient conditions

Xiang, C.; Zhang, Z.-S.; Xia, J.-Q.; Alfatih, A.; Song, Y.; Huang, Y.-J.; Sun, L.-Q.; Wan, G.-Y.; Wang, S.; Wang, Y.; Hu, B.-H.; Zhang, G.; Peng, Q.; Li, S.; Yu, L.; Wu, J.

10.1101/2021.02.19.432039 — plant biology — Posted on 2021-02-20

1206 Divergence in a stress-associated gene regulatory network underlies differential growth control in the Brassicaceae family

Sun, Y.; Oh, D.-H.; Duan, L.; Ramachandran, P.; Ramirez, A.; Bartlett, A.; Dassanayake, M.; Dinneny, J. R.

10.1101/2020.11.18.349449 — plant biology — Posted on 2021-02-20

1207 Defining the transcriptional signature of esophageal-to-skin lineage conversion

Bejar, M. T.; Jimenez-Gomez, P.; Moutsopoulos, I.; Colom, B.; Han, S.; Calero-Nieto, F. J.; Göttgens, B.; Mohorianu, I.; Simons, B. D.; Alcolea, M.

10.1101/2021.02.19.431899 — cell biology — Posted on 2021-02-19

1208 The action of Con-ikot-ikot toxin on single AMPA-type glutamate receptors

Baranovic, J.; Braunbeck, S.; Zaki, N.; Minniberger, S.; Chebli, M.; Plested, A. J.

10.1101/2021.02.19.432041 — neuroscience — Posted on 2021-02-19

1209 Practices and trends in last-mile delivery of poultry vaccines in rural areas in developing countries: the case of Newcastle disease vaccine delivery in Bungoma County, Kenya

Ogolla, K. O.; Chemuliti, J. K.; Mbogoh, S. G.; Mochabo, K. M.; Kibore, B. K.

10.1101/2021.02.19.431949 — pathology — Posted on 2021-02-19

1210 Time series models for prediction of Leptospirosis in different climate zones in Sri LankaTime series models for prediction of Leptospirosis in different climate zones in Sri Lanka

Warnasekara, J.; Agampodi, S.; Abeynayake, R.

10.1101/2021.02.19.431948 — bioinformatics — Posted on 2021-02-19

1211 Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo.

Saenz, S. A.; Local, A.; Carr, T.; Shakya, A.; Koul, S.; Hu, H.; Chourb, L.; Stedman, J.; Malley, J.; DAgostino, L. A.; Shanmugasundaram, V.; Malona, J.; Schwartz, C. E.; Beebe, L.; Clements, M.; Rajaraman, G.; Cho, J.; Jiang, L.; Dubrovskiy, A.; Kreilein, M.; Shimanovich, R.; Hamann, L. G.; Escoubet, L.; Ellis, J. M.

10.1101/2021.02.19.431952 — immunology — Posted on 2021-02-19

1212 Predictive Coding Models for Pain Perception

Song, Y.; Yao, M.; Kemprecos, H.; byrne, a.; Xiao, Z.; Zhang, Q.; Singh, A.; Wang, J.; Chen, Z. S.

10.1101/843284 — neuroscience — Posted on 2021-02-19

1213 Behavioral control by depolarized and hyperpolarized states of an integrating neuron

Sordillo, A.; Bargmann, C. I.

10.1101/2021.02.19.431690 — neuroscience — Posted on 2021-02-19

1214 Structural connectome fingerprinting and age prediction in pediatric development: assessing voxel- and surface-based white matter connectivity

Al-Sharif, N. B.; St-Onge, E.; Vogel, J. W.; Descoteaux, M.; Evans, A. C.

10.1101/2021.02.19.432024 — neuroscience — Posted on 2021-02-19

1215 The molecular infrastructure of glutamatergic synapses in the mammalian forebrain

Peukes, J.; Lovatt, M.; Leistner, C.; Boulanger, J.; Morado, D. R.; Kukulski, W.; Zhu, F.; Komiyama, N. H.; Briggs, J. A. G.; Grant, S. G. N.; Frank, R. A. W.

10.1101/2021.02.19.432002 — neuroscience — Posted on 2021-02-19

1216 Countering reproducibility issues in mathematical models with software engineering techniques: A case study using a one-dimensional mathematical model of the atrioventricular node

Schölzel, C.; Blesius, V.; Ernst, G.; Goesmann, A.; Dominik, A.

10.1101/2021.02.19.431951 — systems biology — Posted on 2021-02-19

1217 Comparative Analysis of Genetically-Modified Crops: Conditional Equivalence Criteria

Jiang, C.; Meng, C.; Schapaugh, A. W.; Jin, H.

10.1101/2021.02.19.431950 — plant biology — Posted on 2021-02-19

1218 SPaRTAN, a computational framework for linking cell-surface receptors to transcriptional regulators

Ma, X.; Somasundaram, A.; Qi, Z.; Singh, H.; Osmanbeyoglu, H. U.

10.1101/2020.12.22.423961 — bioinformatics — Posted on 2021-02-19

1219 FGF8-mediated signaling regulates tooth developmental pace and size during odontogenesis

Lin, C.; Ruan, N.; Li, L.; Chen, Y.; Hu, X.; Chen, Y.; Hu, X.; Zhang, Y.

10.1101/2020.09.16.299388 — developmental biology — Posted on 2021-02-19

1220 Prophage-encoded phage defence proteins with cognate self-immunity

Owen, S. V.; Wenner, N.; Dulberger, C. L.; Rodwell, E. V.; Bowers-Barnard, A.; Quinones-Olvera, N.; Rigden, D. J.; Rubin, E. J.; Garner, E. C.; Baym, M.; Hinton, J. C. D.

10.1101/2020.07.13.199331 — microbiology — Posted on 2021-02-19

1221 A Substantia Innominata-midbrain Circuit Controls a General Aggressive Response

Zhu, Z.; Ma, Q.; Miao, L.; Yang, H.; Pan, L.; Li, K.; Zhang, X.; Wu, J.; Hao, S.; Lin, S.; Ma, X.; Hao, Y.; Duan, S.; Yu, Y.-q.

10.1101/2020.04.22.047670 — neuroscience — Posted on 2021-02-19

1222 Paradoxical Roles of Peritumoral Hepatic Stellate Cells in Liver Tumorigenesis in Mice: Retarding Tumor Growth and Promoting Tumor Dissemination

Zhu, L.; Tian, C.; Li, L.; Fan, L.; Brown, A.; Norris, E. J.

10.1101/2021.02.19.432035 — cancer biology — Posted on 2021-02-19

1223 Invasive atypical non-typhoidal Salmonella in The Gambia

Kanteh, A.; Sesay, A. K.; Alikhan, N.-F.; Ikumapayi, U. N.; Salaudeen, R.; Manneh, J.; Olatunji, Y.-A.; Page, A. J.; Mackenzie, G.

10.1101/2021.02.18.431831 — genomics — Posted on 2021-02-19

1224 Dynamic evolution of MLKL in primate and poxvirus genomes indicates necroptosis is a critical, not auxiliary, countermeasure during infection

Palmer, S.; Chappidi, S.; Pinkham, C.; Hancks, D.

10.1101/2021.02.19.432003 — evolutionary biology — Posted on 2021-02-19

1225 Reduction of HDAC2 expression in human induced pluripotent stem cell derived neurons improves neuronal maturation, mitochondrial dynamics and cellular neurodegenerative disease phenotypes.

Frankowski, H.; Yeboah, F.; Berry, B.; Kinoshita, C.; Lee, M.; Evitts, K.; Davis, J.; Kinoshita, Y.; Morrison, R. S.; Young, J. E.

10.1101/2021.01.18.427156 — neuroscience — Posted on 2021-02-19

1226 Automated Annotation of Cell Identities in Dense Cellular Images

Chaudhary, S.; Lee, S. A.; Li, Y.; Patel, D. S.; Lu, H.

10.1101/2020.03.10.986356 — neuroscience — Posted on 2021-02-19

1227 Gene prioritization based on random walks with restarts and absorbing states, to define gene sets regulating drug pharmacodynamics from single-cell analyses

Sales-de-Queiroz, A.; Sales Santa Cruz, G.; Jean-Marie, A.; Mazauric, D.; Roux, J.; Cazals, F.

10.1101/2021.02.19.431974 — systems biology — Posted on 2021-02-19

1228 HuR -dependent SOD2 protein synthesis is an early adaptation of ovarian cancer cells in response to anchorage independence

Kim, Y. S.; Welles, J. E.; Tang, P. W.; Javed, Z.; Elhaw, A. T.; Mythreye, K.; Kimball, S. R.; Hempel, N.

10.1101/2021.02.19.432010 — cancer biology — Posted on 2021-02-19

1229 Droplet and fibril formation of the functional amyloid Orb2

Ashami, K.; Falk, A. S.; Hurd, C.; Garg, S.; Cervantes Cortes, S. A.; Rawat, A.; Siemer, A. B.

10.1101/2021.02.19.430336 — biophysics — Posted on 2021-02-19

1230 Theoretical basis for stabilizing messenger RNA through secondary structure design

Wayment-Steele, H. K.; Kim, D. S.; Choe, C. A.; Nicol, J. J.; Wellington-Oguri, R.; Watkins, A. M.; Parra Sparberg, R. A.; Huang, P.; Eterna Massive Open Laboratory, ; Das, R.

10.1101/2020.08.22.262931 — biophysics — Posted on 2021-02-19

1231 CoxBase: an online platform for epidemiological surveillance, visualization, analysis and typing of Coxiella burnetii genomic sequence

Fasemore, A. M.; Helbich, A.; Walter, M.; Dandekar, T.; Vergnaud,, G.; Foerstner, K. U.; Frangoulidis, D.

10.1101/2020.11.29.402362 — bioinformatics — Posted on 2021-02-19

1232 A method for detection of permeation events in Molecular Dynamics simulations of lipid bilayers

Camilo, C. R. d. S.; Ruggiero, J. R.; de Araujo, A. S.

10.1101/2021.01.20.427278 — bioinformatics — Posted on 2021-02-19

1233 Incorporating Gene Expression in Genome-wide Prediction of Chromatin Accessibility via Deep Learning

Liu, Q.; Hua, K.; Zhang, X.; Wong, W. H.; Jiang, R.

10.1101/610642 — bioinformatics — Posted on 2021-02-19

1234 Tissue context determines the penetrance of regulatory DNA variation

Halow, J.; Byron, R.; Hogan, M. S.; Ordonez, R.; Groudine, M.; Bender, M. A.; Stamatoyannopoulos, J. A.; Maurano, M. T.

10.1101/2020.06.27.175422 — genomics — Posted on 2021-02-19

1235 Complex polyploid and hybrid species in an apomictic and sexual tropical forage grass group: genomic composition and evolution in Urochloa (Brachiaria) species

Tomaszewska, P.; Vorontsova, M. S.; Renvoize, S. A.; Ficinski, S. Z.; Tohme, J.; Schwarzacher, T.; Castiblanco, V.; de Vega, J. J.; Mitchell, R. A. C.; Heslop-Harrison, P.

10.1101/2021.02.19.431966 — genomics — Posted on 2021-02-19

1236 Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases

Ritchie, S. C.; Lambert, S. A.; Arnold, M.; Teo, S. M.; Lim, S.; Scepanovic, P.; Marten, J.; Zahid, S.; Chaffin, M.; Liu, Y.; Abraham, G.; Ouwehand, W. H.; Roberts, D. J.; Watkins, N. A.; Drew, B. G.; Calkin, A.; Di Angelantonio, E.; Soranzo, N.; Burgess, S.; Chapman, M.; Kathiresan, S.; Khera, A. V.; Danesh, J.; Butterworth, A. S.; Inouye, M.

10.1101/2019.12.14.876474 — genetics — Posted on 2021-02-19

1237 Identification of Maternal-Effect Genes in Zebrafish using Maternal Crispants

Moravec, C. E.; Voit, G. C.; Otterlee, J.; Pelegri, F.

10.1101/2021.02.19.432057 — developmental biology — Posted on 2021-02-19

1238 Genetic manipulation using hepatocyte-targeting adeno-associated viral vectors has minimal off-target effects.

Kiourtis, C.; Wilczynska, A.; Nixon, C.; Clark, W.; May, S.; Bird, T. G.

10.1101/2021.02.19.431990 — cell biology — Posted on 2021-02-19

1239 Notch-Jagged signaling complex defined by an interaction mosaic

Zeronian, M. R.; Klykov, O.; Portell i de Montserrat, J.; Konijnenberg, M. J.; Gaur, A.; Scheltema, R. A.; Janssen, B. J. C.

10.1101/2021.02.19.432005 — molecular biology — Posted on 2021-02-19

1240 Dimerisation of APOBEC1 is dispensable for its RNA/DNA editing activity and modulates its availability

Chieca, M.; Montini, M. D.; Severi, F.; Lembo, G.; Donati, F.; Pecori, R.; Conticello, S. G.

10.1101/410803 — molecular biology — Posted on 2021-02-19

1241 A simple pressure-assisted method for MicroED specimen preparation

Zhao, J.; Xu, H.; Lebrette, H.; Carroni, M.; Taberman, H.; Hogbom, M.; Zou, X.

10.1101/665448 — molecular biology — Posted on 2021-02-19

1242 Live cell imaging reveals that RecA finds homologous DNA by reduced dimensionality search

Wiktor, J.; Gynna, A. H.; Leroy, P.; Larsson, J.; Coceano, G.; Testa, I.; Elf, J.

10.1101/2020.02.13.946996 — microbiology — Posted on 2021-02-19

1243 Mosquito saliva sialokinin-dependent enhancement of arbovirus infection through endothelial barrier leakage

Lefteri, D.; Bryden, S.; Pingen, M.; Terry, S.; Beswick, E.; Georgiev, G.; Van Der Laan, M.; Mastrullo, V.; Campagnolo, P.; Waterhouse, R. M.; Varjak, M.; Merits, A.; Fragkoudis, R.; Griffin, S.; Pondeville, E.; McKimmie, C. S.

10.1101/2021.02.19.431961 — microbiology — Posted on 2021-02-19

1244 Recoding enhances the metabolic capabilities of two novel methylotrophic Asgardarchaeota lineages

Sun, J.; Evans, P. N.; Gagen, E. J.; Woodcroft, B. J.; Hedlund, B. P.; Woyke, T.; Hugenholtz, P.; Rinke, C.

10.1101/2021.02.19.431964 — microbiology — Posted on 2021-02-19

1245 Vesicular stomatitis virus chimeras expressing the Oropouche virus glycoproteins elicit protective immune responses in mice.

Stubbs, S. H.; Pontelli, M. C.; MISHRA, N.; Zhuo, C.; Souza, J. d. P.; Viana, R. M. M.; Lipkin, W. I. H.; Knipe, D.; Arruda, E. A.; Whelan, S. P. J.

10.1101/2021.02.19.432025 — microbiology — Posted on 2021-02-19

1246 Interacting rhythms enhance sensitivity of target detection in a fronto-parietal computational model of visual attention

Aussel, A.; Fiebelkorn, I. C.; Kastner, S.; Kopell, N. J.; Pittman-Polletta, B. R.

10.1101/2021.02.18.431872 — neuroscience — Posted on 2021-02-19

1247 Increased amphetamine-induced hyperactivity in translin (Tsn) KO mice is driven by elevated adiposity

Fu, X.; Shah, A. P.; Keighron, J.; Mou, T.-C. M.; Ladenheim, B.; Alt, J.; Fukudome, D.; Niwa, M.; Tamashiro, K.; Tanda, G.; Sawa, A.; Cadet, J.-L.; Rais, R.; Baraban, J. M.

10.1101/2020.10.08.331447 — neuroscience — Posted on 2021-02-19

1248 Promoting axon regeneration by enhancing the non-coding function of the injury-responsive coding gene Gpr151

Lee, B.; Lee, J.; Jeon, Y.; Kim, H.; Kwon, M.; Shin, J. E.; Cho, Y.

10.1101/2021.02.19.431965 — neuroscience — Posted on 2021-02-19

1249 Hippocampal sharp wave-ripples and the associatedsequence replay emerge from structured synapticinteractions in a network model of area CA3

Ecker, A.; Bagi, B.; Vertes, E.; Steinbach-Nemeth, O.; Karlocai, M. R.; Papp, O. I.; Miklos, I.; Hajos, N.; Freund, T. F.; Gulyas, A. I.; Kali, S.

10.1101/2021.02.18.431868 — neuroscience — Posted on 2021-02-19

1250 Gut microbial taxa elevated by dietary sugar disrupt memory function

Noble, E. E.; Olson, C.; Davis, E. A.; Tsan, L.; Chen, Y.-W.; Schade, R.; Liu, C.; Suarez, A. N.; Jones, R. B.; de La Serre, C.; Yang, X.; Hsiao, E. Y.; Kanoski, S.

10.1101/2020.06.16.153809 — neuroscience — Posted on 2021-02-19

1251 Combinatorial engineering of bulk-assembled monodisperse coacervate droplets towards logically integrated protocells

Li, Q.; Song, Q.; Wei, J.; Cao, Y.; Chen, D.; Shum, H. C.

10.1101/2021.02.19.432011 — synthetic biology — Posted on 2021-02-19

1252 Designing efficient genetic code expansion in Bacillus subtilis to gain biological insights

Stork, D. A.; Squyres, G. R.; Kuru, E.; Gromek, K. A.; Rittichier, J.; Jog, A.; Burton, B. M.; Church, G. M.; Garner, E. C.; Kunjapur, A. M.

10.1101/2021.02.19.432053 — synthetic biology — Posted on 2021-02-19

1253 Quantitative Analysis of Plasmodesmata Permeability using Cultured Tobacco BY-2 Cells Entrapped in Microfluidic Chips

Shimizu, K.; Kikkawa, M.; Tabata, R.; Kurihara, D.; Kurotani, K.-i.; Honda, H.; Notaguchi, M.

10.1101/2021.02.19.431975 — plant biology — Posted on 2021-02-19

1254 Pregnancy and weaning regulate human maternal liver size and function

Bartlett, A. Q.; Vesco, K. K.; Purnell, J. Q.; Francisco, M.; Goddard, E.; DeBarber, A.; Leo, M. C.; Baetscher, E.; Rooney, W.; Naugler, W.; Guimaraes, A.; Catalano, P.; Schedin, P. J.

10.1101/2021.02.18.431862 — physiology — Posted on 2021-02-19

1255 An mRNA expression-based signature for oncogene-induced replication-stress

Guerrero, S.; Bhattacharya, A.; van der Vegt, B.; Everts, M.; Fehrmann, R.; van Vugt, M.

10.1101/2021.02.19.431930 — cancer biology — Posted on 2021-02-19

1256 Stromal architecture directs early dissemination in pancreatic ductal adenocarcinoma

Ray, A.; Callaway, M.; Rodriguez-Merced, N.; Crampton, A.; Carlson, M.; Emme, K.; Ensminger, E.; Kinne, A.; Schrope, J.; Rasmussen, H.; Jiang, H.; DeNardo, D.; Wood, D.; Provenzano, P.

10.1101/2021.02.19.431984 — cancer biology — Posted on 2021-02-19

1257 Weighted force analysis method for derivation of multidimensional free energy landscapes from adaptively-biased replica simulations

Marinelli, F.; Faraldo-Gomez, J.

10.1101/2021.02.17.431654 — biophysics — Posted on 2021-02-19

1258 A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease risk

Macdonald-Dunlop, E.; Taba, N.; Klaric, L.; Frkatovic, A.; Walker, R.; Hayward, C.; Esko, T.; Haley, C.; Fischer, K.; Wilson, J. F.; Joshi, P. K.

10.1101/2021.02.01.429117 — bioinformatics — Posted on 2021-02-19

1259 Molecular basis for Ras suppressor-1 recruitment to focal adhesions and stabilization of consensus adhesome complex

Fukuda, K.; Lu, F.; Qin, J.

10.1101/2021.02.19.432017 — biochemistry — Posted on 2021-02-19

1260 Succinate is Broadly Tissue-Permeant and Uncouples Mitochondrial Respiration from ATP Synthesis

Hass, D. T.; Robbings, B. M.; Bisbach, C. M.; Giering, E.; Mundinger, T. O.; Sadilek, M.; Sweet, I. R.; Hurley, J. B.

10.1101/2021.02.10.430650 — biochemistry — Posted on 2021-02-19

1261 Collective detection based on visual information in animal groups

Davidson, J. D.; Sosna, M. M. G.; Twomey, C. R.; Sridhar, V. H.; Leblanc, S. P.; Couzin, I. D.

10.1101/2021.02.18.431380 — animal behavior and cognition — Posted on 2021-02-19

1262 RNA-binding proteins regulate aldosterone homeostasis in human steroidogenic cells

Fu, R.; Wellman, K.; Baldwin, A.; Rege, J.; Walters, K.; Hirsekorn, A.; Riemondy, K.; Rainey, W. E.; Mukherjee, N.

10.1101/2021.02.19.431050 — genomics — Posted on 2021-02-19

1263 Parallel Characterization of cis-Regulatory Elements for Multiple Genes UsingCRISPRpath

Ren, X.; Wang, M.; Li, B.; Jamieson, K.; Zheng, L.; Jones, I. R.; Li, B.; Takagi, M. A.; Lee, J.; Maliskova, L.; Tam, T. W.; Yu, M.; Hu, R.; Lee, L.; Abnousi, A.; Li, G.; Li, Y.; Hu, M.; Ren, B.; Wang, W.; Shen, Y.

10.1101/2021.02.19.431931 — genomics — Posted on 2021-02-19

1264 An improved ChEC-seq method accurately maps the genome-wide binding of transcription coactivators and sequence-specific transcription factors

Donczew, R.; Lalou, A.; Devys, D.; Tora, L.; Hahn, S.

10.1101/2021.02.12.430999 — genomics — Posted on 2021-02-19

1265 Thermally tolerant symbionts may explain Caribbean octocoral resilience to heat stress

Pelosi, J. A.; Eaton, K. M.; Mychajliw, S.; terHorst, C. P.; Coffroth, M. A.

10.1101/2020.10.21.349555 — evolutionary biology — Posted on 2021-02-19

1266 Phylogenomic assessment of the role of hybridization and introgression in trait evolution

Wang, Y.; Cao, Z.; Ogilvie, H. A.; Nakhleh, L.

10.1101/2020.09.16.300343 — evolutionary biology — Posted on 2021-02-19

1267 A Multiple Regression Assessment of the Biomineral Urease Activity from Urine Drainpipes of California Rest Areas

Lim, K.; Leverenz, H.; Barnum, S.; Wademan, C.

10.1101/2021.02.18.431895 — ecology — Posted on 2021-02-19

1268 Kinetochores respond to subtle changes in the stability of microtubule attachments

Warren, J. D.; Valles, S. Y.; Compton, D. A.

10.1101/2021.02.19.432040 — cell biology — Posted on 2021-02-19

1269 A Cas-BCAR3 co-regulatory circuit controls lamellipodia dynamics

Steenkiste, E. M.; Berndt, J. D.; Pilling, C.; Simpkins, C.; Cooper, J. A.

10.1101/2021.01.29.428899 — cell biology — Posted on 2021-02-19

1270 A single cell atlas of human teeth

Pagella, P.; De Vargas Roditi, L.; Stadlinger, B.; Moor, A. E.; Mitsiadis, T. A.

10.1101/2021.02.19.431962 — cell biology — Posted on 2021-02-19

1271 Rules for the self-assembly of ESCRT-III on endosomes

Sprenger, S.; Migliano, S. M.; Oleschko, F.; Kobald, M.; Hess, M. W.; Teis, D.

10.1101/2021.02.19.431979 — cell biology — Posted on 2021-02-19

1272 Recoding enhances the metabolic capabilities of two novel methylotrophic Asgardarchaeota lineages

Sun, J.; Evans, P. N.; Gagen, E. J.; Woodcroft, B. J.; Hedlund, B. P.; Woyke, T.; Hugenholtz, P.; Rinke, C.

10.1101/2021.02.19.431964 — microbiology — Posted on 2021-02-19

1273 A Protein A based Staphylococcus aureus vaccine with improved safety

Shi, M.; Chen, X.; Sun, Y.; Kim, H. K.; Schneewind, O.; Missiakas, D. M.

10.1101/2021.02.19.432007 — microbiology — Posted on 2021-02-19

1274 Immune Lag Is a Major Cost of Prokaryotic Adaptive Immunity During Viral Outbreaks

Weissman, J. L.; Alseth, E. O.; Meaden, S.; Westra, E. R.; Fuhrman, J. A.

10.1101/2020.09.30.321075 — microbiology — Posted on 2021-02-19

1275 A novel mechanosensitive channel controls osmoregulation, differentiation and infectivity in Trypanosoma cruzi

Dave, N.; Cetiner, U.; Arroyo, D.; Fonbuena, J.; Tiwari, M.; Barrera, P.; Lander, N.; Anishkin, A.; Sukharev, S.; Jimenez, V.

10.1101/498469 — microbiology — Posted on 2021-02-19

1276 Insights into the regulatory mechanisms of Clostridioides difficile biofilm formation

Buckley, A. M.; Ewin, D.; Moura, I.; Wilcox, M.; Douce, G.

10.1101/2021.02.19.431970 — microbiology — Posted on 2021-02-19

1277 Description of a widespread bacterial secretion system with chemically diverse substrates

Grossman, A. S.; Mauer, T. J.; Forest, K. T.; Goodrich-Blair, H.

10.1101/2020.01.20.912956 — microbiology — Posted on 2021-02-19

1278 Bayesian analysis of source tracking markers to estimate the effects of an urban sanitation intervention on human fecal contamination in Mozambique

Holcomb, D. A.; Knee, J.; Capone, D.; Sumner, T.; Adriano, Z.; Nala, R.; Cumming, O.; Brown, J.; Stewart, J. R.

10.1101/2021.02.19.432000 — microbiology — Posted on 2021-02-19

1279 SMAD4 governs a feedforward regulation of the TGF-beta effects in CD8 T cells that contributes to preventing chronic intestinal inflammation

Igalouzene, R.; Hernandez-Vargas, H.; Benech, N.; Bauche, D.; Barrachina, C.; Dubois, E.; Marie, J. C.; SOUDJA, S. M.

10.1101/2021.02.19.431987 — immunology — Posted on 2021-02-19

1280 Spatially displaced excitation contributes to the encoding of interrupted motion by the retinal direction-selective circuit

Ding, J.; Chen, A.; Chung, J.; Acaron Ledesma, H.; Wu, M.; Berson, D.; Palmer, S.; Wei, W.

10.1101/2020.05.29.124461 — neuroscience — Posted on 2021-02-19

1281 Adequate knowledge of COVID-19 impacts good practices amongst health profession students in the Philippines

Dalanon, J.; Redoble, R.; Belotindos, J.-A.; Delos Reyes, C.; Fabillar, J.; Armero, M. S.; Locsin, R.; Suzuki, Y.; Okura, K.; Matsuka, Y.

10.1101/2021.02.18.431919 — scientific communication and education — Posted on 2021-02-19

1282 TGF-B signaling suppresses TCA cycle metabolism in renal cancer.

Nam, H.; Kundu, A.; Karki, S.; Brinkley, G.; Chandrashekar, D. S.; Kirkman, R. L.; Liu, J.; Liberti, M. V.; Locasale, J. W.; Mitchell, T.; Varambally, S.; Sudarshan, S.

10.1101/2021.02.19.429599 — cancer biology — Posted on 2021-02-19

1283 Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors

Devkota, K.; Schapira, M.; Perveen, S.; Khalili Yazdi, A.; Li, F.; Chau, I.; Ghiabi, P.; Hajian, T.; Loppnau, P.; Bolotokova, A.; Satchell, K. J.; Wang, K.; Li, D.; Liu, J.; Smil, D.; Luo, M.; Jin, J.; Fish, P. V.; Brown, P. J.; Vedadi, M.

10.1101/2021.02.19.424337 — biochemistry — Posted on 2021-02-19

1284 Delivery of recombinant SARS-CoV-2 envelope protein into human cells

Hutchison, J. M.; Capone, R.; Luu, D. D.; Hadziselimovic, A.; Van Horn, W. D.; Sanders, C. R.

10.1101/2021.02.18.431684 — biochemistry — Posted on 2021-02-19

1285 Efficiency Improvements and Discovery of New Substrates for a SARS-CoV-2 Main Protease FRET Assay

Drazic, T.; Kuehl, N.; Leuthold, M. M.; Behnam, M. A.; Klein, C. D.

10.1101/2021.02.19.431973 — biochemistry — Posted on 2021-02-19

1286 Characterization of SdGA, a cold-adapted glucoamylase from Saccharophagus degradans

Wayllace, N. M.; Hedin, N.; Busi, M. V.; Gomez-Casati, D. F.

10.1101/2021.02.19.431967 — biochemistry — Posted on 2021-02-19

1287 Viperin inhibits cholesterol biosynthesis and interacts with enzymes in the cholesterol biosynthetic pathway

Grunkemeyer, T. J.; Ghosh, S.; Patel, A. M.; Sajja, K.; Windak, J.; Basrur, V.; Kim, Y. S.; Nesvizhskii, A. I.; Kennedy, R. T.; Marsh, E. N. G.

10.1101/2021.02.19.431989 — biochemistry — Posted on 2021-02-19

1288 From predictive models to cognitive models: Separable behavioral processes underlying reward learning in the rat

Miller, K. J.; Botvinick, M. M.; Brody, C. D.

10.1101/461129 — animal behavior and cognition — Posted on 2021-02-19

1289 SARS-CoV-2 variant evolution in the United States: High accumulation of viral mutations over time likely through serial Founder Events and mutational bursts.

Tasakis, R. N.; Samaras, G.; Jamison, A.; Lee, M.; Paulus, A.; Whitehouse, G.; Verkoczy, L.; Papavasiliou, F. N.; Diaz, M.

10.1101/2021.02.19.431311 — genetics — Posted on 2021-02-19

1290 Antiviral activity of influenza A virus defective interfering particles against SARS-CoV-2 replication in vitro through stimulation of innate immunity

Rand, U.; Kupke, S. Y.; Shkarlet, H.; Hein, M. D.; Hirsch, T.; Marichal-Gallardo, P.; Cicin-Sain, L.; Reichl, U.; Bruder, D.

10.1101/2021.02.19.431972 — microbiology — Posted on 2021-02-19

1291 Strategies to assure optimal trade-offs among competing objectives for genetic improvement of soybean

Ramasubramanian, V.; Beavis, W. D.

10.1101/2021.02.19.431938 — genetics — Posted on 2021-02-19

1292 Drivers of inter-population variation in the gut microbiomes of sister species of Phanaeus dung beetles

Winfrey, C. C.; Sheldon, K. S.

10.1101/2021.02.19.431932 — ecology — Posted on 2021-02-19

1293 Dispersal syndromes affect ecosystem functioning in ciliate microcosms

Raffard, A.; Campana, J.; Legrand, D.; Schtickzelle, N.; Jacob, S.

10.1101/2021.02.19.431939 — ecology — Posted on 2021-02-19

1294 Whole-genome analysis of antimicrobial-resistant Escherichia coli in human gut microbiota reveals its origin and flexibility in transmitting mcr-1

Ding, Y.; Saw, W.-Y.; Tan, L. W. L.; Moong, D. K. N.; Nagarajan, N.; Teo, Y. Y.; Seedorf, H.

10.1101/2021.02.19.431933 — microbiology — Posted on 2021-02-19

1295 Extracellular riboflavin induces anaerobic biofilm formation in Shewanella oneidensis

Edel, M.; Sturm, G.; Sturm-Richter, K.; Wagner, M.; Novion Ducassou, J.; Coute, Y.; Horn, H.; Gescher, J.

10.1101/2021.02.19.431833 — microbiology — Posted on 2021-02-19

1296 Stable behavioral state-specific large scale activity patterns in the developing cortex of neonates

Mojtahedi, N.; Kovalchuk, Y.; Boettcher, A.; Garaschuk, O.

10.1101/2021.02.19.431943 — neuroscience — Posted on 2021-02-19

1297 The effect of hydrophobic gases on the nervous system of Daphnia magna

Robledo-Sanchez, K. C. M.; Ruiz-Suarez, J. C.

10.1101/2021.02.19.431892 — neuroscience — Posted on 2021-02-19

1298 MVPA does not reveal neural representations of hierarchical linguistic structure in MEG

Arana, S. L.; Schoffelen, J.-M.; Mitchell, T.; Hagoort, P.

10.1101/2021.02.19.431945 — neuroscience — Posted on 2021-02-19

1299 The biosynthesis of phospholipids is linked to the cell cycle in a model eukaryote

Vitova, M.; Lanta, V.; Cizkova, M.; Jakubec, M.; Rise, F.; Halskau, O.; Bisova, K.; Furse, S.

10.1101/2021.02.19.431944 — systems biology — Posted on 2021-02-19

1300 Messages From the Small Intestine Carried by Extracellular Vesicles in Prediabetes: a Proteomic Portrait

Ferreira, I.; de Oliveira, R. M.; Carvalho, A. S.; Beck, H. C.; Matthiesen, R.; Silva, B. C.; Macedo, M. P.

10.1101/2021.02.19.431856 — pathology — Posted on 2021-02-19

1301 Selective MAP1LC3C (LC3C) autophagy requires noncanonical initiation regulators and the paralog-specific C-terminal peptide

Czyzyk-Krzeska, M. F.; Bischoff, M. E.; Zang, Y.; Chou, J.; Price, A. D.; Talbot, N. J.; Newbold, M. J.; Paul, A.; Guan, J.-L.; Plas, D. R.; Meller, J.

10.1101/2021.02.19.431861 — cancer biology — Posted on 2021-02-19

1302 An Interpretable Deep Learning Approach for Biomarker Detection in LC-MS Proteomics Data

Iravani, S.; Conrad, T. O. F.

10.1101/2021.02.19.431935 — bioinformatics — Posted on 2021-02-19

1303 Comparing optimized exoskeleton assistance of the hip, knee, and ankle in single and multi-joint configurations

Franks, P. W.; Bryan, G. M.; Martin, R. M.; Reyes, R.; Collins, S. H.

10.1101/2021.02.19.431882 — bioengineering — Posted on 2021-02-19

1304 Establishment of a human three-dimensional chip-based chondro-synovial co-culture joint model for reciprocal cross-talk studies in arthritis research

Rothbauer, M.; Byrne, R. A.; Schobesberger, S.; Olmos Calvo, I.; Fischer, A.; Reihs, E.; Spitz, S.; Bachmann, B. E. M.; Sevelda, F.; Holinka, J.; Holnthoner, W.; Redl, H.; Toegel, S.; Windhager, R.; Kiener, H. P.; Ertl, P.

10.1101/2021.02.19.431936 — bioengineering — Posted on 2021-02-19

1305 Genetic diversification of persistent Mycobacterium abscessus within Cystic Fibrosis patients

Lewin, A.; Kamal, E.; Semmler, T.; Winter, K.; Kaiser, S.; Schaefer, H.; Mao, L.; Eschenhagen, P.; Grehn, C.; Schwarz, C.

10.1101/2021.02.19.431934 — genomics — Posted on 2021-02-19

1306 Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidence for a two-Path Neolithic expansion to Western Europe

Rohrlach, A. B.; Papac, L.; Childebayeva, A.; Rivollat, M.; Villalba-Mouco, V.; Neumann, G. U.; Penske, S.; Skourtanioti, E. B.; van de Loosdrecht, M.; Akar, M.; Boyadzhiev, K.; Boyadzhiev, Y.; Deguilloux, M.-F.; Dobes, M.; Erdal, Y. S.; Ernee, M.; Frangipane, M.; Furmanek, M.; Friederich, S.; Ghesquiere, E.; Haluszko, A.; Hansen, S.; Kuessner, M.; Mannino, M.; Oezbal, R.; Reinhold, S.; Rottier, S.; Salazar-Garcia, D. C.; Diaz, J. S.; Stockhammer, P. W.; de Togores Munoz, C. R.; Yener, K. A.; Posth, C.; Krause, J.; Herbig, A.; Haak, W.

10.1101/2021.02.19.431761 — genetics — Posted on 2021-02-19

1307 Relative and quantitative rhizosphere microbiome profiling result in distinct abundance patterns

Azarbad, H.; Tremblay, J.; Bainard, L. D.; Yergeau, E.

10.1101/2021.02.19.431941 — ecology — Posted on 2021-02-19

1308 Aedes albopictus bionomics in Procida Island, a promising Mediterranean site for the assessment of innovative and community-based integrated pest management methods.

Caputo, B.; Langella, G.; Petrella, V.; Virgillito, C.; Manica, M.; Filipponi, F.; Varone, M.; Primo, P.; Puggioli, A.; Bellini, R.; D'Antonio, C.; Iesu, L.; Tullo, L.; Rizzo, C.; Longobardi, A.; Sollazzo, G.; Perrotta, M. M.; Fabozzi, M.; Palmieri, F.; Saccone, G.; Rosa, R.; della Torre, A.; Salvemini, M.

10.1101/2021.02.19.431954 — ecology — Posted on 2021-02-19

1309 Cultivation-based quantification and identification of bacteria at two hygienic key sides of domestic washing machines

Jacksch, S.; Zohra, H.; Weide, M.; Schnell, S.; Egert, M.

10.1101/2021.02.19.431940 — microbiology — Posted on 2021-02-19

1310 Rapid neural categorization of facelike objects predicts the perceptual awareness of a face (face pareidolia)

Rekow, D.; Baudouin, J.-Y.; Brochard, R.; Rossion, B.; Leleu, A.

10.1101/2021.02.19.431826 — neuroscience — Posted on 2021-02-19

1311 Cryo-TEM simulations of amorphous radiation-sensitive samples using multislice wave propagation.

Himes, B. A.; Grigorieff, N.

10.1101/2021.02.19.431636 — biophysics — Posted on 2021-02-19

1312 Combined Metabolic Activators decrease liver steatosis by activating mitochondrial metabolism in a Golden Syrian hamster study

Yang, H.; Mayneris-Perxachs, J.; Boque, N.; Bas, J. M. d.; Arola, L.; Yuan, M.; Turkez, H.; Uhlen, M.; Boren, J.; Zhang, C.; Mardinoglu, A.; Caimari, A.

10.1101/2021.02.19.431968 — systems biology — Posted on 2021-02-19

1313 Predicting the zoonotic capacity of mammal species for SARS-CoV-2

Fischhoff, I. R.; Castellanos, A. A.; Rodrigues, J. P. G. L. M.; Varsani, A.; Han, B. A.

10.1101/2021.02.18.431844 — ecology — Posted on 2021-02-19

1314 Decreased neutralization of SARS-CoV-2 global variants by therapeutic anti-spike protein monoclonal antibodies

Tada, T.; Dcosta, B. M.; Zhou, H.; Vaill, A.; Kazmierski, W.; Landau, N. R.

10.1101/2021.02.18.431897 — immunology — Posted on 2021-02-19

1315 ESC - a comprehensive resource for SARS-CoV-2 immune escape variants

Rophina, M.; Pandhare, K.; Shamnath, A.; Imran, M.; Jolly, B.; Scaria, V.

10.1101/2021.02.18.431922 — bioinformatics — Posted on 2021-02-19

1316 Insights into the secondary structural ensembles of the full SARS-CoV-2 RNA genome in infected cells

Lan, T. C. T.; Allan, M. F.; Malsick, L.; Khandwala, S.; Nyeo, S. S. Y.; Sun, Y.; Guo, J. U.; Bathe, M.; Griffiths, A.; Rouskin, S.

10.1101/2020.06.29.178343 — biochemistry — Posted on 2021-02-19

1317 Association of CXCR6 with COVID-19 severity: Delineating the host genetic factors in transcriptomic regulation

Dai, Y.; Wang, J.; Jeong, H.-H.; Chen, W.; Jia, P.; Zhao, Z.

10.1101/2021.02.17.431554 — genetics — Posted on 2021-02-19

1318 Concentration and dosage sensitivity of proteins driving liquid-liquid phase separation

Farahi, N.; Lazar, T.; Wodak, S. J.; Tompa, P.; Pancsa, R.

10.1101/2021.02.19.430946 — molecular biology — Posted on 2021-02-19

1319 An Exhaustive Multiple Knockout Approach to Understanding Cell Wall Hydrolase Function in Bacillus subtilis

Wilson, S.; Garner, E. C.

10.1101/2021.02.18.431929 — microbiology — Posted on 2021-02-19

1320 Transcriptomic and metabolomic responses to carbon and nitrogen sources in Methylomicrobium album BG8

Sugden, S.; Lazic, M.; Sauvageau, D.; Stein, L. Y.

10.1101/2021.02.18.431927 — microbiology — Posted on 2021-02-19

1321 Long SARS-CoV-2 nucleocapsid sequences in blood monocytes collected soon after hospital admission

Pagano, N.; Laurent-Rolle, M.; Hsu, J. C.; Yale IMPACT Research Team, ; Vogels, C. B.; Grubaugh, N. D.; Manuelidis, L.

10.1101/2020.12.16.423113 — microbiology — Posted on 2021-02-19

1322 Utility of SARS-CoV-2 infection models using in vitro and in vivo ACE2-lentivirus transduction

Rawle, D. J.; Le, T. T.; Dumenil, T.; Yan, K.; Tang, B.; Bishop, C.; Suhrbier, A.

10.1101/2021.02.09.430547 — microbiology — Posted on 2021-02-19

1323 Constructing An Adult Orofacial Premotor Atlas In Allen Mouse CCF

Takatoh, J.; Park, J. H.; Lu, J.; Li, S.; Thompson, P. M.; Han, B.-X.; Zhao, S.; Kleinfeld, D.; Friedman, B.; Wang, F.

10.1101/2021.02.18.431923 — neuroscience — Posted on 2021-02-19

1324 Analysis of motor unit spike trains estimated from high-density surface electromyography is highly reliable across operators

Hug, F.; Avrillon, S.; Del Vecchio, A.; Casolo, A.; Ibanez, J.; Nuccio, S.; Rossato, J.; Holobar, A.; Farina, D.

10.1101/2021.02.19.431376 — neuroscience — Posted on 2021-02-19

1325 Somatic hypomethylation of pericentromeric SST1 repeats and tetraploidization in human colorectal cancer cells

Gonzalez, B.; Navarro-Jimenez, M.; Alonso-De Gennaro, M. J.; Jansen, S. M.; Granada, I.; Perucho, M.; Alonso, S.

10.1101/2021.02.19.431645 — cancer biology — Posted on 2021-02-19

1326 Rapid Characterization of AAV gene therapy vectors by Mass Photometry

Wu, D.; Hwang, P.; Li, T.; Piszczek, G.

10.1101/2021.02.18.431916 — biophysics — Posted on 2021-02-19

1327 scMM: Mixture-of-experts multimodal deep generative model for single-cell multiomics data analysis.

Minoura, K.; Abe, K.; Nam, H.; Nishikawa, H.; Shimamura, T.

10.1101/2021.02.18.431907 — bioinformatics — Posted on 2021-02-19

1328 Deep Learning-Based Approaches for Decoding Motor Intent from Peripheral Nerve Signals

Luu, D. K.; Nguyen, A. T.; Jiang, M.; Xu, J.; Drealan, M. W.; Cheng, J.; Keefer, E. W.; Zhao, Q.; Yang, Z.

10.1101/2021.02.18.431483 — bioengineering — Posted on 2021-02-19

1329 Effects of early geometric confinement on the transcriptomic profile of human cerebral organoids

Sen, D.; Voulgaropoulos, A.; Keung, A. J.

10.1101/2021.02.18.431674 — bioengineering — Posted on 2021-02-19

1330 ClusterMap: multi-scale clustering analysis of spatial gene expression

He, Y.; Tang, X.; Huang, J.; Zhou, H.; Chen, K.; Liu, A.; Ren, J.; Shi, H.; Lin, Z.; Li, Q.; Aditham, A.; Shu, J.; Liu, J.; Wang, X.

10.1101/2021.02.18.431337 — genomics — Posted on 2021-02-19

1331 A Multiple Regression Assessment of the Biomineral Urease Activity from Urine Drainpipes of California Rest Areas

Lim, K.; Leverenz, H.; Barnum, S.; Wademan, C.

10.1101/2021.02.18.431895 — ecology — Posted on 2021-02-19

1332 Roadkill islands: carnivore extinction shifts seasonal use of roadside carrion by generalist avian scavenger

Fielding, M. W.; Buettel, J. C.; Brook, B. W.; Stojanovic, D.; Yates, L. A.

10.1101/2021.02.18.429855 — ecology — Posted on 2021-02-19

1333 Light and noise pollution impacts specialist wildlife species disproportionately

Ditmer, M. A.; Francis, C. D.; Barber, J. R.; Stoner, D. C.; Seymoure, B. M.; Fristrup, K. M.; Carter, N. H.

10.1101/2021.02.18.431905 — ecology — Posted on 2021-02-19

1334 Heavy-tailed abundance distributions from stochastic Lotka-Volterra models

Descheemaeker, L.; Grilli, J.; de Buyl, S.

10.1101/2021.02.19.431657 — ecology — Posted on 2021-02-19

1335 Inferring Ecosystem Networks as Information Flows

Li, J.; Convertino, M.

10.1101/2021.02.18.431917 — ecology — Posted on 2021-02-19

1336 A comparative analysis of SARS-CoV-2 antivirals in human airway models characterizes 3CLpro inhibitor PF-00835231 as a potential new treatment for COVID-19

de Vries, M.; Mohamed, A.; Prescott, R. A.; Valero-Jimenez, A.; Desvignes, L.; O'Connor, R.; Steppan, C.; Devlin, J. C.; Ivanova, E.; Herrera, A.; Schinlever, A.; Loose, P.; Ruggles, K.; Koralov, S.; Anderson, A.; Binder, J.; Dittmann, M.

10.1101/2020.08.28.272880 — microbiology — Posted on 2021-02-19

1337 West Nile virus in crocodiles and mosquitoes in Zimbabwe

Roy, M.; Mufunda, F.; Slawski, D.; Mutswiri, C.; Mvere, I.; Slawski, K.; Kelly, P.; Bezuidenhout, A.; Piras, I.; Hanyire, T.; Markey, B.; Barry, G.

10.1101/2021.02.19.431612 — microbiology — Posted on 2021-02-19

1338 Analysis of the blood microbiome in a porcine model of fecal-induced peritonitis

Hyun, H.; Lee, M. S.; Park, I.; Ko, H. S.; Yun, S.; Jang, D.-H.; Kim, S.; Kim, H.; Kang, J. H.; Lee, J. H.; Kwon, T.

10.1101/2021.02.18.431914 — microbiology — Posted on 2021-02-19

1339 Development and validation of a miniaturized host range screening assay for bacteriophages

Ng, R. N.; Grey, L. J.; Vaitekenas, A.; McLean, S. A.; Laucirica, D. R.; Poh, M. W.-P.; Hillas, J.; Winslow, S. G.; Iszatt, J. J.; Iosifidis, T.; Tai, A. S.; Agudelo-Romero, P.; Chang, B. J.; Stick, S. M.; Kicic, A.

10.1101/2021.02.18.431904 — microbiology — Posted on 2021-02-19

1340 Grasp aperture corrections in reach-to-grasp movements do not alter size perception

van Polanen, V.

10.1101/2021.02.18.431812 — neuroscience — Posted on 2021-02-19

1341 BREVIPEDICELLUS and ERECTA mediate expression of AtPRX17 in preventing Arabidopsis callus retardation and browning

Xie, J.; Qi, B.; Mou, C.; Wu, Y.; Wang, L.; Jiao, Y.; Dou, Y.; Zheng, H.

10.1101/2021.02.18.431912 — plant biology — Posted on 2021-02-19

1342 CO2 supply modulates lipid remodelling, photosynthetic and respiratory activities in Chlorella species

Cecchin, M.; Paloschi, M.; Busnardo, G.; Cazzaniga, S.; Cuine, S.; Li-Beisson, Y.; Wobbe, L.; Ballottari, M.

10.1101/2021.02.18.431842 — plant biology — Posted on 2021-02-19

1343 PEAK3 pseudokinase represents a pro-migratory and -invasive signalling scaffold

Hou, J.; Nguyen, E. V.; Surudoi, M.; Roy, M. J.; Patel, O.; Lucet, I. S.; Ma, X.; Daly, R. J.

10.1101/2021.02.17.431740 — cancer biology — Posted on 2021-02-19

1344 CK2 phosphorylation of human papillomavirus 16 E2 on serine 23 promotes interaction with TopBP1 and is critical for E2 plasmid retention function

Morgan, I. M.; Prabhakar, A. T.; James, C. D.; Das, D.; Otoa, R.; Day, M.; Burgner, J. W.; Fontan, C. T.; Wang, X.; Wieland, A.; Donaldson, M. M.; Bristol, M. L.; Li, R.; Oliver, A.; Pearl, L. H.; Smith, B. O.

10.1101/2021.02.17.431757 — molecular biology — Posted on 2021-02-19

1345 Host-virus chimeric events in SARS-CoV2 infected cells are infrequent and artifactual

Yan, B.; Chakravorty, S.; Mirabelli, C.; Wang, L.; Trujillo-Ochoa, J. L.; Chauss, D.; Kumar, D.; Lionakis, M. S.; Olson, M. R.; Wobus, C. E.; Afzali, B.; Kazemian, M.

10.1101/2021.02.17.431704 — microbiology — Posted on 2021-02-19

1346 Toxoplasma gondii injected neurons localize to the cortex and striatum and have altered firing

Mendez, O. A.; Machado, E. F.; Lu, J.; Koshy, A. A.

10.1101/2021.02.18.431839 — microbiology — Posted on 2021-02-19

1347 The trypanosome UDP-glucose pyrophosphorylase is imported by piggybacking into glycosomes where unconventional sugar nucleotide synthesis takes place

Villafraz, O.; Baudouin, H.; Mazet, M.; Kulyk, H.; Dupuy, J.-W.; Pineda, E.; Botte, C. Y.; Inaoka, D.; Portais, J.-C.; Bringaud, F.

10.1101/2021.02.17.431754 — microbiology — Posted on 2021-02-19

1348 A whole-brain imaging-based systems approach to understand origin of addiction in binge-like drinking model

Stefaniuk, M.; Monika, P.; Klaudia, N.; Baranski, M.; Zielinski, Z.; Bijoch, Łukasz; Legutko, D.; Majka, P.; Bednarek, S.; Jermakow, N.; Wojcik, D.; Kaczmarek, L.

10.1101/2021.02.17.431586 — neuroscience — Posted on 2021-02-19

1349 Systematic Phenotyping and Characterization of the 5xFAD mouse model of Alzheimer's Disease

Forner, S.; Kawauchi, S.; Balderrama-Gutierrez, G.; Kramar, E. A.; Matheos, D. P.; Phan, J.; Javonillo, D. I.; Minh Tran, K.; Hingco, E.; da Cunha, C.; Rezaie, N.; Alcantara, J. A.; Baglietto-Vargas, D.; Jansen, C.; Neumann, J.; Wood, M. A.; MacGregor, G. R.; Mortazavi, A.; Tenner, A. J.; LaFerla, F. M.; Green, K. N.

10.1101/2021.02.17.431716 — neuroscience — Posted on 2021-02-19

1350 Intracellular NASPM allows an unambiguous functional measure of GluA2-lacking calcium-permeable AMPA receptor prevalence

Coombs, I. D.; Bats, C.; Sexton, C. A.; Cull-Candy, S. G.; Farrant, M.

10.1101/2021.02.18.431828 — neuroscience — Posted on 2021-02-19

1351 Muscle-specific economy of force generation and efficiency of work production during human running

Bohm, S.; Mersmann, F.; Santuz, A.; Schroll, A.; Arampatzis, A.

10.1101/2021.02.18.431789 — biophysics — Posted on 2021-02-19

1352 The possible fidelity-speed-proofreading cost trade-offs in DNA replication due to the exonuclease proofreading

Li, Q.; Shu, Y.; Fu, W.; Ouyang, Z.; Li, M.

10.1101/2021.02.18.431768 — biophysics — Posted on 2021-02-19

1353 RaptGen: A variational autoencoder with profile hidden Markov model for generative aptamer discovery

Iwano, N.; Adachi, T.; Aoki, K.; Nakamura, Y.; Hamada, M.

10.1101/2021.02.17.431338 — bioinformatics — Posted on 2021-02-19

1354 Adsorption of Azo Dyes by a Novel Bio-Nanocomposite Based on Whey Protein Nanofibrils and Nano-clay: Equilibrium Isotherm and Kinetic Modeling

Rahimi Aqdam, S.; Otzen, D. E.; Mahmoodi, N. M.; Morshedi, D.

10.1101/2020.11.24.394205 — bioengineering — Posted on 2021-02-19

1355 ATLASx: a computational map for the exploration of biochemical space

Mohammadi-Peyhani, H.; Hafner, J.; Sveshnikova, A.; Viterbo, V.; Hatzimanikatis, V.

10.1101/2021.02.17.431583 — biochemistry — Posted on 2021-02-19

1356 Drosophila glue protects from predation

Borne, F.; Prigent, S. R.; Molet, M.; Courtier-Orgogozo, V.

10.1101/2020.12.23.424162 — evolutionary biology — Posted on 2021-02-19

1357 Fetal estrogens are not involved in sex determination but critical for early ovarian differentiation.

Jolivet, G.; Daniel-Carlier, N.; Harscoet, E.; Airaud, E.; Dewaele, A.; Pierson, C.; Giton, F.; Boulanger, L.; Daniel, N.; Mandon-Pepin, B.; Pannetier, M.; Pailhoux, E.

10.1101/2020.12.13.419770 — developmental biology — Posted on 2021-02-19

1358 Autocrine regulation of adult neurogenesis by the endocannabinoid 2-arachidonoylglycerol (2-AG)

Schuele, L.-L.; Schuermann, B.; Bilkei-Gorzo, A.; Zimmer, A.; Leidmaa, E.

10.1101/2021.02.11.430731 — neuroscience — Posted on 2021-02-19

1359 Sexual dimorphism and plasticity in wing shape in three Diptera

Reis, M.; Siomava, N.; Wimmer, E. A.; Posnien, N.

10.1101/135749 — zoology — Posted on 2021-02-19

1360 A small RNA is linking CRISPR-Cas and zinc transport

Märkle, P.; Maier, L.-K.; Maass, S.; Hirschfeld, C.; Bartel, J.; Becher, D.; Voss, B.; Marchfelder, A.

10.1101/2021.02.19.431937 — molecular biology — Posted on 2021-02-19

1361 Spatially confined sub-tumor microenvironments orchestrate pancreatic cancer pathobiology

Grünwald, B. T.; Devisme, A.; Andrieux, G.; Vyas, F.; Aliar, K.; McCloskey, C. W.; Macklin, A.; Jang, G. H.; Denroche, R.; Romero, J. M.; Bavi, P.; Bronsert, P.; Notta, F.; O'Kane, G.; Wilson, J.; Knox, J.; Tamblyn, L.; Radulovich, N.; Fischer, S. E.; Boerries, M.; Gallinger, S.; Kislinger, T. R.; Khokha, R.

10.1101/2021.02.18.431890 — cancer biology — Posted on 2021-02-19

1362 Glioblastoma remodeling of neural circuits in the human brain decreases survival

Krishna, S.; Choudhury, A.; Seo, K.; Ni, L.; Kakaizada, S.; Lee, A.; Aabedi, A.; Cao, C.; Sudharshan, R.; Egladyous, A.; Almeida, N.; Venkatesh, H.; Findlay, A.; Nagarajan, S.; Raleigh, D.; Brang, D.; Monje, M.; Hervey-Jumper, S.

10.1101/2021.02.18.431915 — cancer biology — Posted on 2021-02-19

1363 Pseudomonas can prevent the parasitic fungus, while keeping the crop fungus unaffected, in the gardens of Odontotermes obesus.

Agarwal, R.; Gupta, M.; Antony, A.; Sen, R.; Raychoudhury, R.

10.1101/2021.01.29.428757 — evolutionary biology — Posted on 2021-02-19

1364 A Guide to Pre-Processing High-Throughput Animal Tracking Data

Gupte, P. R.; Beardsworth, C. E.; Spiegel, O.; Lourie, E.; Toledo, S.; Nathan, R.; Bijleveld, A. I.

10.1101/2020.12.15.422876 — ecology — Posted on 2021-02-19

1365 Comparative analysis of Alzheimer's disease knock-in model brain transcriptomes implies changes to energy metabolism as a causative pathogenic stress

Barthelson, K.; Newman, M.; Lardelli, M.

10.1101/2021.02.16.431539 — neuroscience — Posted on 2021-02-19

1366 Probabilistic discrimination of relative stimulus features in mice

Lyamzin, D. R.; Aoki, R.; Abdolrahmani, M.; Benucci, A.

10.1101/2020.12.20.423700 — neuroscience — Posted on 2021-02-19

1367 Predicting Brain Amyloid using Multivariate Morphometry Statistics, Sparse Coding, and Correntropy: Validation in 1,101 Individuals from the ADNI and OASIS Databases

Wu, J.; Dong, Q.; Gui, J.; Zhang, J.; Su, Y.; Chen, K.; Thompson, P. M.; Caselli, R. J.; Reiman, E. M.; Ye, J.; Wang, Y.

10.1101/2020.10.16.343137 — neuroscience — Posted on 2021-02-19

1368 Latching dynamics as a basis for short-term recall

Ryom, K. I.; Boboeva, V.; Soldatkina, O.; Treves, A.

10.1101/2021.02.18.431782 — neuroscience — Posted on 2021-02-18

1369 Membrane-binding mechanism of the EEA1 FYVE domain revealed by multi-scale molecular dynamics simulations

Sansom, M. S. P.; Larsen, A. H.; Tata, L.; John, L.

10.1101/2021.02.18.431783 — biophysics — Posted on 2021-02-18

1370 Modelling the visual world of a velvet worm

Ljungholm, M.; Nilsson, D.-E.

10.1101/2021.02.18.431781 — animal behavior and cognition — Posted on 2021-02-18

1371 Induction of specific antibodies, IgG-secreting plasmablasts and memory B cells following BCG vaccination

Bitencourt, J.; Wilkie, M.; Peralta Alvarez, M. P.; Jacobs, A.; Wright, D.; Harris, S. A.; Smith, S. G.; Elias, S.; White, A.; Sharpe, S.; O'Shea, M. K.; McShane, H.; Tanner, R.

10.1101/2021.02.18.431837 — immunology — Posted on 2021-02-18

1372 Cellular, Circuit and Transcriptional Framework for Modulation of Itch in the Central Amygdala

Samineni, V. K.; Grajales-Reyes, J.; Grajales-Reyes, G. E.; Tycksen, E.; Copits, B.; Pedersen, C.; Ankudey, E.; Sackey, J. N.; Sewell, S. B.; Bruchas, M. R.; Gereau, R. W.

10.1101/2021.02.18.431884 — neuroscience — Posted on 2021-02-18

1373 A Neural Signature of Regularity in Sound is Reduced in Older Adults

Herrmann, B.; Maess, B.; Johnsrude, I. S.

10.1101/2021.02.18.431898 — neuroscience — Posted on 2021-02-18

1374 Impact of immediate cryopreservation on the establishment of patient derived xenografts from head and neck cancer patients.

Abel, L.; Durmaz, A.; Hu, R.; Longhurst, C.; Baschnagel, A. M.; Wheeler, D. L.; Scott, J. G.; Kimple, R. J.

10.1101/2020.02.03.930891 — cancer biology — Posted on 2021-02-18

1375 Dopaminergic Modulation of Working Memory and Cognitive Flexibility in a Zebrafish Model of Aging-Related Cognitive Decline

Cleal, M.; Fontana, B. D.; Double, M.; Mezbrovschi, R.; Parcell, L.; Redhead, E. S.; Parker, M. O.

10.1101/2020.06.05.136077 — animal behavior and cognition — Posted on 2021-02-18

1376 Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases

Korsunsky, I.; Wei, K.; Pohin, M.; Kim, E. Y.; Barone, F.; Kang, J. B.; Friedrich, M.; Turner, J.; Nayar, S.; Fisher, B. A.; Raza, K.; Marshall, J. L.; Croft, A. P.; Sholl, L. M.; Vivero, M.; Rosas, I. O.; Bowman, S. J.; Coles, M.; Frei, A. P.; Lassen, K.; Filer, A.; Powrie, F.; Buckley, C. D.; Brenner, M. B.; Raychaudhuri, S.

10.1101/2021.01.11.426253 — genomics — Posted on 2021-02-18

1377 Social network architecture and the tempo of cumulative cultural evolution

Cantor, M.; Chimento, M.; Smeele, S. Q.; He, P.; Papageorgiou, D.; Aplin, L. M.; Farine, D. R.

10.1101/2020.12.04.411934 — evolutionary biology — Posted on 2021-02-18

1378 Quantifying habitat and landscape effects on composition and structure of plant-pollinator networks in the US Northern Great Plains

Vilella-Arnizaut, I. B.; Nottebrock, H.; Fenster, C. B.

10.1101/2021.02.12.431025 — ecology — Posted on 2021-02-18

1379 Influenza-specific effector memory B cells predict long-lived antibody responses to vaccination in humans

Nellore, A.; Zumaquero, E.; Scharer, C. D.; King, R. G.; Tipton, C. M.; Fucile, C.; Mousseau, B.; Bradley, J. E.; Mi, T.; Goepfert, P. A.; Kearney, J. F.; Boss, J. M.; Randall, T. D.; Sanz, I.; Rosenberg, A.; Lund, F. E.

10.1101/643973 — immunology — Posted on 2021-02-18

1380 Functional cooperativity mediated by rationally selected combinations of human monoclonal antibodies targeting the henipavirus receptor binding protein

10.1101/2021.02.17.431743 — immunology — Posted on 2021-02-18

1381 Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits

Yao, H. K.; Guet-McCreight, A.; Mazza, F.; Moradi Chameh, H.; Prevot, T. D.; Griffiths, J.; Tripathy, S. J.; Valiante, T. A.; Sibille, E.; Hay, E.

10.1101/2021.02.17.431698 — neuroscience — Posted on 2021-02-18

1382 Brain network motifs are markers of loss and recovery of consciousness

Duclos, C.; Nadin, D.; Mahdid, Y.; Tarnal, V.; Picton, P.; Vanini, G.; Golmirzaie, G.; Janke, E.; Avidan, M. S.; Kelz, M. B.; Mashour, G. A.; Blain-Moraes, S.

10.1101/2020.03.16.993659 — neuroscience — Posted on 2021-02-18

1383 FRAGMENTED BIODIVERSITY: FERNS AND LYCOPHYTES FROM FOREST FRAGMENTS IN JUIZ DE FORA, MINAS GERAIS, BRAZIL

Lima, L. V.; Dittrich, V. A.; Souza, F. S.; Fonseca, C. R.; Salino, A.

10.1101/2021.02.17.431701 — plant biology — Posted on 2021-02-18

1384 Redefining colorectal cancer classification and clinical stratification through a single-cell atlas

Khaliq, A. M.; kurt, z.; Grunvald, M. W.; Erdogan, C.; Turgut, S. S.; Rand, T.; Khare, S.; Borgia, J. A.; Hayden, D. M.; Pappas, S. G.; Govekar, H. R.; Bhama, A. R.; Singh, A.; Jacobson, R. A.; Kam, A. E.; Zloza, A.; Reiser, J.; Catenacci, D. V.; Turaga, K.; Radovich, M.; Thyparambil, S.; Levy, M. A.; Subramanian, J.; Kuzel, T. M.; Sadanandam, A.; Hussain, A.; El-Rayes, B.; Salahudeen, A.; Masood, A.

10.1101/2021.02.02.429256 — cancer biology — Posted on 2021-02-18

1385 Weighted force analysis method for derivation of multidimensional free energy landscapes from adaptively-biased replica simulations

Marinelli, F.; Faraldo-Gomez, J.

10.1101/2021.02.17.431654 — biophysics — Posted on 2021-02-18

1386 Relating simulation studies by provenance--Developing a family of Wnt signaling models

Budde, K.; Smith, J.; Wilsdorf, P.; Haack, F.; Uhrmacher, A. M.

10.1101/2021.02.18.430807 — bioinformatics — Posted on 2021-02-18

1387 Variational autoencoders learn universal latent representations of metabolomics data

Gomari, D. P.; Schweickart, A.; Cerchietti, L.; Paietta, E.; Fernandez, H.; Al-Amin, H.; Suhre, K.; Krumsiek, J.

10.1101/2021.01.14.426721 — bioinformatics — Posted on 2021-02-18

1388 Meta-Analysis of Oxidative Transcriptomes in Insects

Bono, H.

10.1101/2021.02.01.427354 — bioinformatics — Posted on 2021-02-18

1389 Mechanical Mapping of Bioprinted Hydrogel Models by Brillouin Microscopy

Mahmodi, H.; Utama, R.; Piloni, A.; Kabakova, I.

10.1101/2021.02.18.431535 — bioengineering — Posted on 2021-02-18

1390 Massive colonization of protein-coding exons by selfish genetic elements in Paramecium germline genomes

Sellis, D.; Guerin, F.; Arnaiz, O.; Pett, W.; Lerat, E.; Boggetto, N.; Krenek, S.; Berendonk, T.; Couloux, A.; Aury, J.-M.; Labadie, K.; Malinski, S.; Meyer, E.; Sperling, L.; Duret, L.; Duharcourt, S.

10.1101/2020.12.23.424184 — genomics — Posted on 2021-02-18

1391 Bridging the gap: Using reservoir ecology and human serosurveys to estimate Lassa virus spillover in West Africa

Basinski, A. J.; Fichet-Calvet, E. J.; Sjodin, A. R.; Varrelman, T. J.; Remien, C.; Layman, N. C.; Bird, B. H.; Wolking, D. J.; Monagin, C.; Ghersi, B. M.; Barry, P. A.; Jarvis, M. A.; Gessler, P. E.; Nuismer, S. L.

10.1101/2020.03.05.979658 — ecology — Posted on 2021-02-18

1392 Dynamics of hunchback translation in real time and at single mRNA resolution in the Drosophila embryo

Vinter, D. J.; Hoppe, C.; Minchington, T. G.; Sutcliffe, C.; Ashe, H.

10.1101/2021.02.16.430474 — developmental biology — Posted on 2021-02-18

1393 New multiscale characterisation methodology for effective determination of isolation-structure-function relationship of extracellular vesicles.

Phan, T. H.; Divakarla, K. S.; Yeo, J. H.; Lei, Q.; Tharkar, P.; Pansani, T. N.; Leslie, K. G.; Tong, M.; Coleman, V. A.; Jamting, A.; Plessis, M.-D. D.; New, E. J.; Kalionis, B.; Demokritou, P.; Woo, H.-K.; Cho, Y.-K.; Chrzanowski, W.

10.1101/2021.02.09.430523 — cell biology — Posted on 2021-02-18

1394 Temporally and Spatially Partitioned Neuropeptide Release from Individual Clock Neurons

Klose, M. K.; Bruchez, M. P.; Deitcher, D. L.; Levitan, E. S.

10.1101/2020.07.24.219725 — neuroscience — Posted on 2021-02-18

1395 The organizational principles of de-differentiated topographic maps

Liu, P.; Chrysidou, A.; Doehler, J.; Hebart, M.; Wolbers, T.; Kuehn, E.

10.1101/2020.07.08.179978 — neuroscience — Posted on 2021-02-18

1396 Temporal enhancement of cross-adaptation between density and size perception based on the theory of magnitude

Hisakata, R.; Kaneko, H.

10.1101/2021.02.16.431522 — neuroscience — Posted on 2021-02-18

1397 Environmental enrichment mitigates stroke-induced change in sharp-wave associated ripple characteristics

Ip, Z. T.; Rabiller, G.; He, J.-W.; Chavan, S.; Nishijima, Y.; Akamatsu, Y.; Liu, J.; Yazdan-Shahmorad, A.

10.1101/2021.02.12.431002 — neuroscience — Posted on 2021-02-18

1398 The human cerebellum is essential for modulating perceptual sensitivity based on temporal expectations

Breska, A.; Ivry, R. B.

10.1101/2021.01.15.426903 — neuroscience — Posted on 2021-02-18

1399 Real-time single-cell characterizationof the eukaryotic transcription cyclereveals correlations between RNAinitiation, elongation, and cleavage

Liu, J.; Hansen, D.; Eck, E.; Kim, Y. J.; Turner, M. A.; Alamos, S.; Garcia, H. G.

10.1101/2020.08.29.273474 — biophysics — Posted on 2021-02-18

1400 Design of novel CV-N variants: Modulation of binding dynamics through distal mutations

Kazan, I. C.; Sharma, P.; Bobkov, A. A.; Fromme, R.; Ghirlanda, G.; Ozkan, S. B.

10.1101/2020.12.21.423842 — biophysics — Posted on 2021-02-18

1401 Energy deficit-independent stress response in the Frataxin-depleted heart: evidence that Integrated Stress Response can predominate over mTORC1 activation

Vasquez, C.; Patel, M.; Sivaramakrishnan, A.; Bekeova, C.; Anderson-Pullinger, L.; Wang, N.; Tang, H.-Y.; Seifert, E. L.

10.1101/2020.06.12.148361 — biochemistry — Posted on 2021-02-18

1402 Conservation and convergence of genetic architecture in the adaptive radiation of Anolis lizards

McGlothlin, J. W.; Kobiela, M. E.; Wright, H. V.; Kolbe, J. J.; Losos, J. B.; Brodie, E. D.

10.1101/2021.02.18.431064 — evolutionary biology — Posted on 2021-02-18

1403 Inferring genome-wide correlations of mutation fitness effects between populations

Huang, X.; Fortier, A. L.; Coffman, A. J.; Struck, T. J.; Irby, M. N.; James, J. E.; Burguette, J. E.; Ragsdale, A. P.; Gutenkunst, R. N.

10.1101/703918 — evolutionary biology — Posted on 2021-02-18

1404 A signalling axis involving CNOT3, Aurora B and ERK promotes differentiation and survival of mesendodermal progenitor cells

Sarkar, M.; Martufi, M.; Roman-Trufero, M.; Wang, Y.-F.; Whilding, C.; Dormann, D.; Sabbattini, P.; Dillon, N.

10.1101/756932 — developmental biology — Posted on 2021-02-18

1405 TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells.

Silva, B.; Arora, R.; Azzalin, C. M.

10.1101/2021.02.18.431840 — cell biology — Posted on 2021-02-18

1406 A genetic program boosts mitochondrial function to power macrophage tissue invasion

Emtenani, S.; Martin, E. T.; Gyoergy, A.; Bicher, J.; Wendelin-Genger, J.; Koecher, T.; Hurd, T.; Bergthaler, A.; Rangan, P.; Siekhaus, D. E.

10.1101/2021.02.18.431643 — cell biology — Posted on 2021-02-18

1407 YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation

He, L.; Pratt, H.; Wei, F.; Gao, M.; Weng, Z.; Struhl, K.

10.1101/2021.02.18.431832 — molecular biology — Posted on 2021-02-18

1408 Probing cortical excitability under GABAergic modulation

Lepeu, G.; Van Maren, E.; Slabeva, K.; Fuchs, M.; Anso, J.; Z'Graggen, W.; Pollo, C.; Schindler, K.; Adamantidis, A.; Baud, M. O.

10.1101/2021.02.18.431873 — neuroscience — Posted on 2021-02-18

1409 Burst coding despite unimodal interval distributions

Williams, E.; Payeur, A.; Gidon, A.; Naud, R.

10.1101/2021.02.18.431851 — neuroscience — Posted on 2021-02-18

1410 Dopaminergic Ric GTPase activity impacts amphetamine sensitivity and sleep quality in a dopamine transporter-dependent manner in Drosophila melanogaster

Fagan, R. R.; Kearney, P. J.; Luethi, D.; Bolden, N. C.; Sitte, H. H.; Emery, P.; Melikian, H. E.

10.1101/2021.02.18.431857 — neuroscience — Posted on 2021-02-18

1411 Cortical Magnification in Human Visual Cortex Parallels Task Performance around the Visual Field

Benson, N. C.; Kupers, E. R.; Barbot, A.; Carrasco, M.; Winawer, J.

10.1101/2020.08.26.268383 — neuroscience — Posted on 2021-02-18

1412 Mapping the organization and dynamics of the posterior medial network during movie watching

Cooper, R.; Kurkela, K.; Davis, S. W.; Ritchey, M.

10.1101/2020.10.21.348953 — neuroscience — Posted on 2021-02-18

1413 Pregnancy and weaning regulate human maternal liver size and function

Bartlett, A. Q.; Francisco, M.; Goddard, E.; DeBarber, A.; Leo, M. C.; Baetscher, E.; Rooney, W.; Naugler, W.; Catalano, P.; Guimaraes, A.; Purnell, J. Q.; Vesco, K. K.; Schedin, P. J.

10.1101/2021.02.18.431862 — physiology — Posted on 2021-02-18

1414 Physiological and ecological consequences of the water optical properties degradation on reef corals

Lopez-Londono, T.; Galindo-Martinez, C. T.; Gomez-Campo, K.; Gonzalez-Guerrero, L. A.; Roitman, S.; Pollock, F. J.; Pizarro, V.; Lopez-Victoria, M.; Medina, M.; Iglesias-Prieto, R.

10.1101/2021.02.18.431834 — physiology — Posted on 2021-02-18

1415 BRAF inhibitors reprogram cancer-associated fibroblasts to drive matrix remodeling and therapeutic escape in melanoma

Liu, T.; Zhou, L.; Xiao, Y.; Andl, T.; Zhang, Y.

10.1101/2021.02.18.431841 — cancer biology — Posted on 2021-02-18

1416 Macromolecular Regulators Have Matching Effects on the Phase Equilibrium and Interfacial Tension of Biomolecular Condensates

Mazarakos, K.; Zhou, H.-X.

10.1101/2021.02.18.431854 — biophysics — Posted on 2021-02-18

1417 MethReg: estimating the regulatory potential of DNA methylation in gene transcription

Silva, T.; Young, J. I.; Martin, E.; Chen, X.; Wang, L.

10.1101/2021.02.18.431696 — bioinformatics — Posted on 2021-02-18

1418 Magnetically-Propelled Fecal Surrogates for Modeling the Impact of Solid-Induced Shear Forces on Primary Colonic Epithelial Cells

Hinman, S. S.; Huling, J.; Wang, Y.; Wang, H.; Bretherton, R. C.; DeForest, C. A.; Allbritton, N. L.

10.1101/2021.02.18.431336 — bioengineering — Posted on 2021-02-18

1419 Mechanical Mapping of Bioprinted Hydrogel Models by Brillouin Microscopy

Mahmodi Sheikh Sarmast, H.; Utama, R.; Piloni, A.; kabakova, I.

10.1101/2021.02.18.431535 — bioengineering — Posted on 2021-02-18

1420 Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia

MARTIN, L.; KACI, N.; BENOIST-LASSELIN, C.; MONDOLONI, M.; DECAUDAVEINE, S.; ESTIBALS, V.; CORNILLE, M.; LOISAY, L.; FLIPO, J.; DEMUYNCK, B.; DE LA LUZ CADIZ-GURREA, M.; BARBAULT, F.; FERNANDEZ-ARROYO, S.; SCHIBLER, L.; SEGURA-CARRETERO, A.; DAMBROISE, E.; LEGEAI-MALLET, L.

10.1101/2021.02.18.431801 — developmental biology — Posted on 2021-02-18

1421 ChEC-seq: a robust method to identify protein-DNA interactions genome-wide

Bruzzone, M. J.; Albert, B.; Hafner, L.; Kubik, S.; Lezaja, A.; Mattarocci, S.; Shore, D. M.

10.1101/2021.02.18.431798 — molecular biology — Posted on 2021-02-18

1422 A glimpse into the diverse cellular immunity against SARS-CoV-2

Chang, L.-J.; Chang, C.-W.; Liu, Y.; Jiao, C.; Liu, H.; Chen, X.

10.1101/2021.02.17.431750 — microbiology — Posted on 2021-02-18

1423 SARS-CoV-2 nucleocapsid protein dually regulates innate immune responses

Zhao, Y.; Sui, L.; Wu, P.; Wang, W.; Tan, G.; Wang, Z.; Yu, Y.; Hou, Z.; Wang, G.; Liu, Q.

10.1101/2021.02.17.431755 — microbiology — Posted on 2021-02-18

1424 Meta-analysis of orthogonal OMICs data from COVID-19 patients unveils prognostic markers and antiviral factors.

Biji, A.; Swaraj, S.; Khatun, O.; Narayan, R.; Sardar, R.; Satish, D.; Mehta, S.; Bindhu, H.; Jeevan, M.; Saini, D. K.; Singh, A.; Gupta, D.; Tripathi, S.

10.1101/2021.02.18.431825 — microbiology — Posted on 2021-02-18

1425 Rotavirus as an Expression Platform of the SARS-CoV-2 Spike Protein

Philip, A. A.; Patton, J. T.

10.1101/2021.02.18.431835 — microbiology — Posted on 2021-02-18

1426 Human microglia extensively reconstitute in humanized BLT mice with human interleukin-34 transgene and support HIV-1 brain infection

Zhang, J.; Lohani, S. C.; Cheng, Y.; Wang, T.; Guo, L.; Kim, W.-K.; Gorantla, S.; Li, Q.

10.1101/2021.02.18.431677 — microbiology — Posted on 2021-02-18

1427 Homologous and heterologous serological response to the N-terminal domain of SARS-CoV-2

Lv, H.; Tsang, O. T.-Y.; So, R. T. Y.; Wang, Y.; Liu, H.; Yip, G. K.; Teo, Q. W.; Lin, Y.; Liang, W.; Wang, J.; Ng, W. W.; Wilson, I. A.; Peiris, M.; Wu, N. C.; Mok, C. K. P.

10.1101/2021.02.17.431722 — immunology — Posted on 2021-02-18

1428 Brain endothelial CXCL12 attracts protective Natural Killer cells during ischemic stroke

Wang, S.; de Fabritus, L.; Ashok Kumar, P.; Werner, Y.; Siret, C.; Simic, M.; Kerdiles, Y. M.; Stumm, R.; van de Pavert, S. A.

10.1101/2021.02.18.431426 — immunology — Posted on 2021-02-18

1429 Viral route of infection determines the effect of Drosophila melanogaster gut bacteria on host resistance and tolerance to disease.

Landum, M.; Silva, M. S.; Martins, N.; Teixeira, L.

10.1101/2021.02.18.431843 — immunology — Posted on 2021-02-18

1430 Ultrastructural analysis of dendritic spine necks reveals a continuum of spine morphologies

Ofer, N.; Berger, D. R.; Kasthuri, N.; Lichtman, J. W.; Yuste, R.

10.1101/2021.02.18.431725 — neuroscience — Posted on 2021-02-18

1431 Fast A-type currents shape a rapidly adapting form of delayed short latency firing of excitatory superficial dorsal horn neurons that express the NPY Y1 receptor

Sinha, G. P.; Prasoon, P.; Smith, B. N.; Taylor, B. K.

10.1101/2021.02.18.431823 — neuroscience — Posted on 2021-02-18

1432 Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter

Robey, R. W.; Robinson, A. N.; Ali-Rahmani, F.; Huff, L. M.; Lusvarghi, S.; Vahedi, S.; Hotz, J. M.; Warner, A. C.; Butcher, D.; Matta, J.; Edmondson, E. F.; Lee, T. D.; Roth, J. S.; Lee, O. W.; Shen, M.; Tanner, K. D.; Hall, M. D.; Ambudkar, S. V.; Gottesman, M. M.

10.1101/2021.02.18.431829 — pharmacology and toxicology — Posted on 2021-02-18

1433 Engineering the Immune Adaptor Protein STING as a Biologic

Sun, X.; Ni, Y.; He, Y.; Yang, M.; Tani, T.; Kitajima, S.; Barbie, D. A.; Li, J.

10.1101/2021.02.18.431824 — bioengineering — Posted on 2021-02-18

1434 Familial prion disease-related mutation E196K displays a novel amyloid fibril structure revealed by cryo-EM

Wang, L.-Q.; Zhao, K.; Yuan, H.-Y.; Li, X.-N.; Dang, H.-B.; Ma, Y.; Wang, Q.; Wang, C.; Sun, Y.; Chen, J.; Li, D.; Zhang, D.; Yin, P.; Liu, C.; Liang, Y.

10.1101/2021.02.18.431846 — biochemistry — Posted on 2021-02-18

1435 Isolation and characterisation of bacteriophages with activity against invasive non-typhoidal Salmonella causing bloodstream infection in Malawi

Rodwell, E. V.; Wenner, N.; Pulford, C. V.; Cai, Y.; Bowers-Barnard, A.; Beckett, A.; Rigby, J.; Picton, D. M.; Blower, T. R.; Feasey, N. A.; Hinton, J. C. D.; Perez-Sepulveda, B. M.

10.1101/2021.02.18.431836 — microbiology — Posted on 2021-02-18

1436 A Combination Adjuvant for the Induction of Potent Antiviral Immune Responses for a Recombinant SARS-CoV-2 Protein Vaccine

Jangra, S.; Landers, J. J.; Rathnasinghe, R.; O'Konek, J. J.; Janczak, K. W.; Cascalho, M.; Kennedy, A. A.; Tai, A. W.; Baker, J. R.; Schotsaert, M.; Wong, P. T.

10.1101/2021.02.18.431484 — immunology — Posted on 2021-02-18

1437 Biological convolutions improve DNN robustness to noise and generalisation

Evans, B. D.; Malhotra, G.; Bowers, J. S.

10.1101/2021.02.18.431827 — neuroscience — Posted on 2021-02-18

1438 CTCF association with episomal HPV16 genomes regulates viral oncogene transcription and splicing

Groves, I. J.; Tang, G.; Coleman, N.

10.1101/2021.02.18.431881 — cancer biology — Posted on 2021-02-18

1439 Platinum nanoparticles inhibit intracellular ROS generation and protect against Cold Atmospheric Plasma-induced cytotoxicity

Gunes, S.; He, Z.; Malone, R.; Cullen, P. J.; Curtin, J. F.

10.1101/2021.02.18.431888 — cancer biology — Posted on 2021-02-18

1440 Improving Generalizability of Protein Sequence Models with Data Augmentations

Shen, H.; Price, L. C.; Bahadori, M. T.; Seeger, F.

10.1101/2021.02.18.431877 — bioinformatics — Posted on 2021-02-18

1441 Invasive atypical non-typhoidal Salmonella in The Gambia

Kanteh, A.; Sesay, A. K.; Alikhan, N.-F.; Ikumapayi, U. N.; Salaudeen, R.; Manneh, J.; Olatunji, Y.-A.; Page, A. J.; Mackenzie, G.

10.1101/2021.02.18.431831 — genomics — Posted on 2021-02-18

1442 Opposing dominance within a color gene block is associated with maladaptive hybrid signal discordance

de Zwaan, D. R.; Mackenzie, J.; Mikklesen, E.; Wang, S.

10.1101/2021.02.18.431741 — evolutionary biology — Posted on 2021-02-18

1443 Stress-induced glucocorticoids alter the rhythmic activity of Leydig cells depending on the circadian time

Medar, M. L.; Andric, S. A.; Kostic, T. S.

10.1101/2021.02.18.431858 — cell biology — Posted on 2021-02-18

1444 Toxoplasma gondii injected neurons localize to the cortex and striatum and have altered firing

Mendez, O. A.; Machado, E. F.; Lu, J.; Koshy, A. A.

10.1101/2021.02.18.431839 — microbiology — Posted on 2021-02-18

1445 Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22

Schnepf, D.; Hernandez, P.; Mahlakoiv, T.; Crotta, S.; Sullender, M. E.; Peterson, S. T.; Ohnemus, A.; Michiels, C.; Gentle, I.; Dumoutier, L.; Reis, C. A.; Diefenbach, A.; Wack, A.; Baldridge, M. T.; Staeheli, P.

10.1101/2021.02.18.431818 — immunology — Posted on 2021-02-18

1446 neurolib: a simulation framework for whole-brain neural mass modeling

Cakan, C.; Jajcay, N.; Obermayer, K.

10.1101/2021.02.18.431886 — neuroscience — Posted on 2021-02-18

1447 Optogenetic silencing of neurotransmitter release with a naturally occurring invertebrate rhodopsin

Mahn, M.; Saraf-Sinik, I.; Patil, P.; Pulin, M.; Bitton, E.; Karalis, N.; Bruentgens, F.; Palgi, S.; Gat, A.; Dine, J.; Wietek, J.; Davidi, I.; Levy, R.; Litvin, A.; Zhou, F.; Sauter, K.; Soba, P.; Schmitz, D.; Luthi, A.; Rost, B. R.; Wiegert, J. S.; Yizhar, O.

10.1101/2021.02.18.431673 — neuroscience — Posted on 2021-02-18

1448 So you want to be a Super Researcher?

Rathee, S.; Lee, S. L.

10.1101/2021.02.18.431804 — scientific communication and education — Posted on 2021-02-18

1449 Detailed characterization of the UMAMITs provides insight into their evolution, functional properties as amino acid transporters and role in the plant

Zhao, C.; Pratelli, R.; Yu, S.; Shelley, B.; Collakova, E.; Pilot, G.

10.1101/2021.02.18.431885 — plant biology — Posted on 2021-02-18

1450 Retrograde Control of Cytosolic Translation Targets Synthesis of Plastid Localized Proteins and Nuclear Responses for Efficient Light Acclimation.

Moore, M.; Smith, A. B.; Wesemann, C.; Schmidtpott, S.; Wegener, M.; Farooq, M. A.; Seidel, T.; Pogson, B. J.; Dietz, K.-J.

10.1101/2021.02.18.431817 — plant biology — Posted on 2021-02-18

1451 The Wild Worm Codon Adapter: a web tool for automated codon adaptation of transgenes for expression in non-Caenorhabditis nematodes

Bryant, A. S.; Hallem, E. A.

10.1101/2021.02.18.431865 — bioinformatics — Posted on 2021-02-18

1452 Strongyloides RNA-seq Browser: a web-based software platform for on-demand bioinformatics analyses of Strongyloides species

Bryant, A. S.; DeMarco, S. F.; Hallem, E. A.

10.1101/2021.02.18.431867 — bioinformatics — Posted on 2021-02-18

1453 pSONIC: Ploidy-aware Syntenic Orthologous Networks Identified via Collinearity

Conover, J. L.; Sharbrough, J.; Wendel, J. F.

10.1101/2021.02.18.431864 — genomics — Posted on 2021-02-18

1454 Analysis of Structural Variation Among Inbred Mouse Strains Identifies Genetic Factors for Autism-Related Traits

Arslan, A.; Fang, Z.; Wang, M.; Cheng, Z.; Yoo, B.; Bejerano, G.; Peltz, G.

10.1101/2021.02.18.431863 — genomics — Posted on 2021-02-18

1455 Natural variation in fertility is correlated with species-wide levels of divergence in Caenorhabditis elegans

Zhang, G.; Mostad, J. D.; Andersen, E. C.

10.1101/2021.02.18.431866 — genetics — Posted on 2021-02-18

1456 Fetal gut colonization: meconium does not have a detectable microbiota before birth

Kennedy, K.; Gerlach, M. J.; Adam, T.; Heimesaat, M. M.; Rossi, L.; Surette, M. G.; Sloboda, D. M.; Braun, T.

10.1101/2021.02.17.431710 — microbiology — Posted on 2021-02-18

1457 Interacting rhythms enhance sensitivity of target detection in a fronto-parietal computational model of visual attention

Aussel, A.; Fiebelkorn, I. C.; Kastner, S.; Kopell, N. J.; Pittman-Polleta, B. R.

10.1101/2021.02.18.431872 — neuroscience — Posted on 2021-02-18

1458 Hippocampal sharp wave-ripples and the associatedsequence replay emerge from structured synapticinteractions in a network model of area CA3

Ecker, A.; Bagi, B.; Vertes, E.; Steinbach-Nemeth, O.; Karlocai, M. R.; Papp, O.; Miklos, I.; Hajos, N.; Freund, T.; Gulyas, A. I.; Kali, S.

10.1101/2021.02.18.431868 — neuroscience — Posted on 2021-02-18

1459 The effect of hydrophobic gases on the nervous system of Daphnia magna

Robledo-Sanchez, K. C. M.; Ruiz-Suarez, J. C.

10.1101/2021.02.18.431860 — neuroscience — Posted on 2021-02-18

1460 The heart rate discrimination task: a psychophysical method to estimate the accuracy and precision of interoceptive beliefs

Legrand, N.; Nikolova, N.; Correa, C.; Braendholt, M.; Stuckert, A.; Kildahl, N.; Vejlo, M.; Fardo, F.; Allen, M.

10.1101/2021.02.18.431871 — neuroscience — Posted on 2021-02-18

1461 Genome-wide approaches for the identification of markers and genes associated with sugarcane yellow leaf virus resistance

Pimenta, R. J. G.; Aono, A. H.; Villavicencio, R. C. B.; Coutinho, A. E.; da Silva, C. C.; dos Anjos, I. A.; Perecin, D.; Landell, M. G. d. A.; Goncalves, M. C.; Pinto, L. R.; de Souza, A. P.

10.1101/2020.09.04.283614 — plant biology — Posted on 2021-02-18

1462 The oligomannose N-glycans 3D architecture and its response to the FcγRIIIa structural landscape

Fogarty, C. A.; fadda, e.

10.1101/2021.01.11.426234 — biophysics — Posted on 2021-02-18

1463 Tetrazoles as PPARγ ligands: Structural and Computational Investigation.

de Paula, K.; dos Santos, J. C.; Mafud, A. C.; Nascimento, A. S.

10.1101/2021.02.17.431624 — biophysics — Posted on 2021-02-18

1464 Network-based protein-protein interaction prediction method maps perturbations of cancer interactome

Qiu, J.; Chen, K.; Zhong, C.; Zhu, S.; Ma, X.

10.1101/2020.07.01.181776 — bioinformatics — Posted on 2021-02-18

1465 Third Backcross Generation Indonesian Indigenous Chicken Kampong Broiler-Type (Kambro) SOX5 Gene Polymorphism

Ardo, T.; Perdamaian, A. B. I.; Mahardhika, I. W. S.; Daryono, B. S.

10.1101/2021.02.17.431737 — genetics — Posted on 2021-02-18

1466 Compression for population genetic data through finite-state entropy

Chen, W.; Elliott, L. T.

10.1101/2021.02.17.431713 — genetics — Posted on 2021-02-18

1467 Alzheimer's-like remodeling of neuronal ryanodine receptor in COVID-19

Marks, A. R.; Dridi, H.; Reiken, S.; Liu, X.; Sittenfeld, L.

10.1101/2021.02.18.431811 — pathology — Posted on 2021-02-18

1468 Immune characterization and profiles of SARS-CoV-2 infected patients

Policard, M.; Jain, S.; Rego, S.; Dakshanamurthy, S.

10.1101/2021.02.17.431721 — immunology — Posted on 2021-02-18

1469 Discovery of photosynthesis genes through whole-genome sequencing of acetate-requiring mutants of Chlamydomonas reinhardtii

Wakao, S.; Shih, P. M.; Guan, K.; Schackwitz, W.; Ye, J.; Shih, R.; Chovatia, M.; Sharma, A.; Martin, J.; Wei, C.-L.; Niyogi, K. K.

10.1101/2021.02.17.431526 — plant biology — Posted on 2021-02-18

1470 Carotenoid and tocopherol fortification of zucchini fruits using a viral RNA vector

Houhou, F.; Cordero, T.; Aragones, V.; Marti, M.; Cebolla-Cornejo, J.; Perez de Castro, A.; Rodriguez-Concepcion, M.; Pico, B.; Daros, J.-A.

10.1101/2021.02.18.431807 — plant biology — Posted on 2021-02-18

1471 Chemical characterization; Antimicrobial and Larvicidal activity of essential oil from Callistemon citrinus (Bottle brush) leaves

Chachad, D. P.; Dias, A.; Uniyal, K.; Varma, U.; Jadhav, P.; Satvekar, T.; Ghag-Sawant, M.; Mondal, M.; Doshi, N.

10.1101/2021.02.18.431822 — pharmacology and toxicology — Posted on 2021-02-18

1472 Celecoxib exhibits therapeutic potential in experimental model of hyperlipidaemia

Ekor, M.; Owusu Agyei, P. E.; Obese, E.; Biney, R. P.; Henneh, I. T.; Antwi-Adjei, M.; Yahaya, E. S.; Amoakohene, G.; Akakpo, P. K.

10.1101/2021.02.15.431245 — pharmacology and toxicology — Posted on 2021-02-18

1473 Mutation N501Y in RBD of Spike Protein Strengthens the Interaction between COVID-19 and its Receptor ACE2

Tian, F.; Tong, B.; Sun, L.; Shi, S.; Zheng, B.; Wang, Z.; Dong, X.; Zheng, P.

10.1101/2021.02.14.431117 — biophysics — Posted on 2021-02-18

1474 Aggregation Tool for Genomic Concepts (ATGC): A deep learning framework for sparse genomic measures and its application to tumor mutational burden

Anaya, J.; Sidhom, J.-W.; Cummings, C. A.; Baras, A. S.; The AACR Project GENIE Consortium,

10.1101/2020.08.05.237206 — bioinformatics — Posted on 2021-02-18

1475 Rats show a preference for certain unfamiliar strains of rats

Kogo, H.; Kiyokawa, Y.; Takeuchi, Y.

10.1101/2021.02.18.431764 — animal behavior and cognition — Posted on 2021-02-18

1476 Chromosome-level genome assembly of the horned-gall aphid, Schlechtendalia chinensis (Hemiptera: Aphididae: Erisomatinae)

Wei, H.-Y.; Ye, Y.-X.; Huang, H.-J.; Chen, M.-S.; Yang, Z.-X.; Chen, X.-M.; Zhang, C.-X.

10.1101/2021.02.17.431348 — genomics — Posted on 2021-02-18

1477 Peak shifts and extinction under sex-specific selection

De Lisle, S.

10.1101/2021.02.18.431780 — evolutionary biology — Posted on 2021-02-18

1478 Joint inference of species histories and gene flow

Mueller, N. F.; Ogilvie, H.; Zhang, C.; Fontaine, M. C.; Amaya-Romero, J. E.; Drummond, A.; Stadler, T.

10.1101/348391 — evolutionary biology — Posted on 2021-02-18

1479 Still no evidence for disruption of global patterns of nest predation in shorebirds

Bulla, M.; Valcu, M.; Kempenaers, B.

10.1101/2021.02.17.431576 — ecology — Posted on 2021-02-18

1480 Distinct Phenotypes of SARS-CoV-2 Isolates Reveal Viral Traits Critical for Replication in Primary Human Respiratory Cells

Pohl, M. O.; Busnadiego, I.; Kufner, V.; Glas, I.; Karakus, U.; Schmutz, S.; Zaheri, M.; Abela, I.; Trkola, A.; Huber, M.; Stertz, S.; Hale, B. G.

10.1101/2020.10.22.350207 — microbiology — Posted on 2021-02-18

1481 Direct activation of endothelial cells by SARS-CoV-2 nucleocapsid protein is blocked by Simvastatin

Qian, Y.; Lei, T.; Patel, P.; Lee, C.; Monaghan-Nichols, P.; Xin, H.-B.; Qiu, J.; Fu, M.

10.1101/2021.02.14.431174 — immunology — Posted on 2021-02-18

1482 The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates

Li, D.; Edwards, R. J.; Manne, K.; Martinez, D. R.; Schafer, A.; Alam, S. M.; Wiehe, K.; Lu, X.; Parks, R.; Sutherland, L. L.; Oguin, T. H.; McDanal, C.; Perez, L. G.; Mansouri, K.; Gobeil, S. M. C.; Janowska, K.; Stalls, V.; Kopp, M.; Cai, F.; Lee, E.; Foulger, A.; Hernandez, G.; Sanzone, A.; Tilahun, K.; Jiang, C.; Tse, L. V.; Bock, K. W.; Minai, M.; Nagata, B. M.; Cronin, K.; Gee-Lai, V.; Deyton, M.; Barr, M.; Von Holle, T.; Macintyre, A. N.; Stover, E.; Feldman, J.; Hauser, B. M.; Caradonna, T. M.; Scobey, T. D.; Moody, M. A.; Cain, D. W.; DeMarco, C. T.; Denny, T. N.; Woods, C. W.; Petzol

10.1101/2020.12.31.424729 — immunology — Posted on 2021-02-18

1483 MEG, myself, and I: individual identification from neurophysiological brain activity

da Silva Castanheira, J.; Orozco, H. D.; Misic, B.; Baillet, S.

10.1101/2021.02.18.431803 — neuroscience — Posted on 2021-02-18

1484 Functional MRI of native and non-native speech production in sequential German-English bilinguals

Treutler, M.; Sörös, P.

10.1101/2021.02.18.431784 — neuroscience — Posted on 2021-02-18

1485 Disrupting short-term memory in premotor but not visual cortex affects serial dependence in visuomotor integration

de Azevedo Neto, R. M.; Bartels, A.

10.1101/2021.02.18.431802 — neuroscience — Posted on 2021-02-18

1486 Contribution of interneuron subtype-specific GABAergic signalling to emergent sensory processing in somatosensory whisker barrel cortex in mouse.

Baruchin, L. J.; Kohl, M. M.; Butt, S. J. B.

10.1101/2021.02.18.431791 — neuroscience — Posted on 2021-02-18

1487 Perceptual history acts in world-centred coordinates

Mikellidou, K.; Cicchini, G. M.; Burr, D. C.

10.1101/2021.02.18.431805 — neuroscience — Posted on 2021-02-18

1488 Biological and Transcriptomic Characterization of Pre-haustorial Resistance to Sunflower Broomrape (Orobanche cumana W.)

Sisou, D.

10.1101/2021.02.17.431739 — plant biology — Posted on 2021-02-18

1489 Resolving the Interactions Between Class 3 Semaphorin Receptors in Live Cells

Christie, S. M.; Hao, J.; Tracy, E.; Buck, M.; Yu, J. S.; Smith, A. W.

10.1101/2021.02.18.431813 — biophysics — Posted on 2021-02-18

1490 The cryo-EM structure of the neurofibromin dimer reveals the molecular basis for von Recklinghausen disease

Lupton, C. J.; Bayly-Jones, C.; D'Andrea, L.; Huang, C.; Schittenhelm, R. B.; Venugopal, H.; Whisstock, J. C.; Halls, M. L.; Ellisdon, A. M.

10.1101/2021.02.18.431788 — biochemistry — Posted on 2021-02-18

1491 Protein and substrate flexibility contribute to enzymatic specificity in human and bacterial methionine adenosyltransferases

GADE, M. H.; Tan, L. L.; Sandhu, M.; Brock, J. S.; Delaney, A.; Villar-Briones, A.; Jackson, C. J.; Laurino, P.

10.1101/2021.02.18.431797 — biochemistry — Posted on 2021-02-18

1492 Mosquito Larvae (Culex spp.) Startle Responses to Vibration Stimuli

Harrison, E. R.; Budenberg, W. J.

10.1101/2021.02.18.431787 — animal behavior and cognition — Posted on 2021-02-18

1493 Identifying gene regulatory networks of senescence in postharvest broccoli (Brassica oleracea)

Ahlawat, Y.; Li, S.; Pliakoni, E. D.; Brecht, J.; Liu, T.

10.1101/2021.02.18.431815 — genomics — Posted on 2021-02-18

1494 Ancient DNA and microfossils reveal dynamics of three harmful dinoflagellate species off Eastern Tasmania, Australia, over the last 9,000 years

Armbrecht, L.; Paine, B.; Bolch, C. J. S.; Cooper, A.; McMinn, A.; Woodward, C.; Hallegraeff, G.

10.1101/2021.02.18.431790 — genomics — Posted on 2021-02-18

1495 Integration of differential gene expression with weighted gene correlation network analysis identifies genes whose expression is remodeled throughout physiological aging in mouse tissues

Ferreira, M.; Francisco, S.; Soares, A. R.; Nobre, A.; Pinheiro, M.; Reis, A.; Neto, S.; Rodrigues, A. J.; Sousa, N.; Moura, G.; Santos, M. A. S.

10.1101/2021.02.18.431793 — genetics — Posted on 2021-02-18

1496 MITOCHONDRIAL GENOME REVEALS CONTRASTING PATTERN OF ADAPTIVE SELECTION IN TURTLES AND TORTOISES

Sahoo, S.; Kumar, A.; Rai, J.; GUPTA, S. K.

10.1101/2021.02.18.431795 — evolutionary biology — Posted on 2021-02-18

1497 Revisiting the early evolution of Cyanobacteria with a new thylakoid-less and deeply diverged isolate from a hornwort

Rahmatpour, N.; Hauser, D. A.; Nelson, J. M.; Chen, P. Y.; Villarreal, J. C.; Ho, M.-Y.; Li, F.-W.

10.1101/2021.02.18.431691 — evolutionary biology — Posted on 2021-02-18

1498 Replication-related control over cell division in Escherichia coli is growth-rate dependent

Tiruvadi Krishnan, S.; Männik, J.; Kar, P.; Lin, J.; Amir, A.; Männik, J.

10.1101/2021.02.18.431686 — cell biology — Posted on 2021-02-18

1499 Pyrazinamide action is driven by the cell envelope stress response in Mycobacterium tuberculosis

Thiede, J. M.; Dillon, N.; Howe, M. D.; Modlin, S. J.; Aflakpui, R.; Hoffner, S.; Valafar, F.; Minato, Y.; Baughn, A. D.

10.1101/2021.02.17.431758 — microbiology — Posted on 2021-02-18

1500 Indoleamine 2,3-dioxygenase upregulates PD-1 expression on ovarian tumor infiltrating CD8+ T cells via kynurenine activation of the aryl hydrocarbon receptor

Amobi-McCloud, A.; MUTHUSWAMY, R.; Battaglia, S.; Yu, H.; Liu, T.; Wang, J.; Putluri, V.; Singh, P. K.; Qian, F.; Huang, R.-Y.; Putluri, N.; Takemasa, T.; Lugade, A.; Liu, S.; Odunsi, K.

10.1101/2021.02.18.431473 — immunology — Posted on 2021-02-18

1501 Evolving a new efficient mode of fructose utilization for improved bioproduction in Corynebacterium glutamicum

Krahn, I.; Bonder, D.; Torregrosa, L.; Stoppel, D.; Krause, J. P.; Meiswinkel, T. M.; Rosenfeldt, N.; Seibold, G. M.; Wendisch, V. F. N.; Lindner, S. N.

10.1101/2021.02.18.431779 — synthetic biology — Posted on 2021-02-18

1502 Integrating genomics and multi-platform metabolomics enables metabolite QTL detection in breeding-relevant apple germplasm

Bilbrey, E. A.; Williamson, K.; Hatzakis, E.; Doud Miller, D.; Fresnedo Ramirez, J.; Cooperstone, J. L.

10.1101/2021.02.18.431481 — plant biology — Posted on 2021-02-18

1503 Structural basis of drug recognition by the multidrug transporter ABCG2

Kowal, J.; Ni, D.; Jackson, S.; Manolaridis, I.; Stahlberg, H.; Locher, K. P.

10.1101/2021.02.18.431786 — biophysics — Posted on 2021-02-18

1504 Sensitive, reliable, and robust circRNA detection from RNA-seq with CirComPara2

Gaffo, E.; Buratin, A.; Dal Molin, A.; Bortoluzzi, S.

10.1101/2021.02.18.431705 — bioinformatics — Posted on 2021-02-18

1505 Relating simulation studies by provenance--Developing a family of Wnt signaling models

Budde, K.; Smith, J.; Wilsdorf, P.; Haack, F.; Uhrmacher, A. M.

10.1101/2021.02.18.430807 — bioinformatics — Posted on 2021-02-18

1506 TransPi - a comprehensive TRanscriptome ANalysiS PIpeline for de novo transcriptome assembly

Rivera-Vicens, R. E.; Garcia Escudero, C.; Conci, N.; Eitel, M.; Wörheide, G.

10.1101/2021.02.18.431773 — bioinformatics — Posted on 2021-02-18

1507 A covalently crosslinked bioink for multi-materials drop-on-demand 3D bioprinting of three-dimensional cell cultures

Utama, R. H.; Tan, V.; Tjandra, K. C.; Sexton, A.; Nguyen, D.; O'Mahony, A. P.; Ribeiro, J. C. C.; Kavallaris, M.; Gooding, J. J.

10.1101/2021.02.18.431759 — bioengineering — Posted on 2021-02-18

1508 Collective detection based on visual information in animal groups

Davidson, J. D.; Sosna, M. M. G.; Twomey, C. R.; Sridhar, V. H.; Leblanc, S. P.; Couzin, I. D.

10.1101/2021.02.18.431380 — animal behavior and cognition — Posted on 2021-02-18

1509 TKTDsimulation.jl and tktdjl2r: innovative packages for High Performance Computing of survival predictions in support of environmental risk assessment under time-variable scenarios

Baudrot, V.; CHARLES, S.

10.1101/2021.02.18.431769 — ecology — Posted on 2021-02-18

1510 Dynamics and nanoscale organization of the postsynaptic endocytic zone at excitatory synapses

Catsburg, L. A. E.; Westra, M.; Van Schaik, A. M. L.; MacGillavry, H. D.

10.1101/2021.02.18.431766 — cell biology — Posted on 2021-02-18

1511 Competence-associated peptide BriC alters fatty acid biosynthesis in Streptococcus pneumoniae

Aggarwal, S. D.; Gullett, J. M.; Fedder, T.; Safi, J. P. F.; Rock, C. O.; Hiller, N. L.

10.1101/2021.02.17.431746 — microbiology — Posted on 2021-02-18

1512 Fluorescence Imaging-Based Discovery of Membrane Domain-Associated Proteins in Mycobacterium smegmatis

Rokicki, C. A. Z.; Brenner, J. R.; Dills, A. H.; Judd, J. J.; Kester, J. C.; Puffal, J.; Wade, J. T.; Gray, T. A.; Derbyshire, K. M.; Fortune, S.; Morita, Y. S.

10.1101/2021.02.17.431749 — microbiology — Posted on 2021-02-18

1513 Aspergillus fumigatus In-Host HOG pathway mutation for Cystic Fibrosis Lung Microenvironment Persistence

Ross, B. S.; Lofgren, L. A.; Ashare, A.; Stajich, J. E.; Cramer, R. A.

10.1101/2021.02.17.431756 — microbiology — Posted on 2021-02-18

1514 A D-2-hydroxyglutarate biosensor based on specific transcriptional regulator DhdR

Xiao, D.; Zhang, W.; Guo, X.; Liu, Y.; Hu, C.; Guo, S.; Kang, Z.; Xu, X.; Ma, C.; Gao, C.; Xu, P.

10.1101/2021.02.18.430539 — microbiology — Posted on 2021-02-18

1515 Feature-based attention induces surround suppression during the perception of visual motion

Yoo, S.-A.; Martinez-Trujillo, J.; Treue, S.; Tsotsos, J. K.; Fallah, M.

10.1101/2021.02.17.431646 — neuroscience — Posted on 2021-02-18

1516 The P3b differentiates parallel physical and rule-based updating of a sensory model

Schwartze, M.; Bellotti, F. I.; Kotz, S. A.

10.1101/2021.02.17.431659 — neuroscience — Posted on 2021-02-18

1517 Sharing happy stories increases interpersonal closeness mediated by enhancing interpersonal brain synchronization

Enhui, X.; Qin, Y.; Keshuang, L.; Nastase, S. A.; Ruqian, Z.; Ning, W.; Xianchun, L.

10.1101/2021.02.18.431771 — neuroscience — Posted on 2021-02-18

1518 Genome-wide insights into population structure and host specificity of Campylobacter jejuni

Epping, L.; Walther, B.; Piro, R. M.; Knüver, M.-T.; Huber, C.; Thürmer, A.; Flieger, A.; Fruth, A.; Janecko, N.; Wieler, L. H.; Stingl, K.; Semmler, T.

10.1101/2021.02.18.431648 — genomics — Posted on 2021-02-18

1519 Modeling land use impacts on spatial distribution of floating plastic litter in surface water of Southeast Asian archipelago

Wibowo, A. A.

10.1101/2021.02.17.431695 — ecology — Posted on 2021-02-18

1520 Accelerated vaccine induction of IgM neutralising antibody enables same day vaccine protection against a lethal influenza virus challenge

Honda-Okubo, Y.; Li, L.; Baldwin, J.; Petrovsky, N.

10.1101/2021.02.17.431751 — microbiology — Posted on 2021-02-18

1521 Broadly Reactive H2 Hemagglutinin Vaccines Elicit Cross-Reactive Antibodies in Ferrets Pre-Immune to Seasonal Influenza A Viruses

Reneer, Z. B.; Skarlupka, A. L.; Jamieson, P. J.; Ross, T. M.

10.1101/2021.02.17.431747 — immunology — Posted on 2021-02-18

1522 Harmonised segmentation of neonatal brain MRI

Grigorescu, I.; Vanes, L.; Uus, A.; Batalle, D.; Cordero-Grande, L.; Nosarti, C.; Edwards, D.; Hajnal, J.; Modat, M.; Deprez, M.

10.1101/2021.02.17.431611 — neuroscience — Posted on 2021-02-18

1523 Targeted Memory Reactivation of Face-Name LearningDepends on Ample and Undisturbed Slow-Wave Sleep

Whitmore, N. W.; Bassard, A. M.; Paller, K. A.

10.1101/2021.02.16.431530 — neuroscience — Posted on 2021-02-18

1524 Altered cortical phase- and amplitude-coupling in Multiple Sclerosis

Siems, M.; Tuennerhoff, J.; Ziemann, U.; Siegel, M.

10.1101/2021.02.17.431597 — neuroscience — Posted on 2021-02-18

1525 Perceptual restoration fails to recover unconscious processing for smooth eye movements after occipital stroke

Kwon, S.; Huxlin, K. R.; Mitchell, J. F.

10.1101/2021.02.16.431524 — neuroscience — Posted on 2021-02-18

1526 Selective auditory attention detection using dynamic learning systems: The study of RNN and reinforcement learning

Geravanchizadeh, M.; Roushan, H.

10.1101/2021.02.18.431748 — neuroscience — Posted on 2021-02-18

1527 Daily caffeinated soda intake is associated with impaired working memory and higher impulsivity in children

Kwon, M.; Kim, H.; Yang, J.; Hur, J.; Lee, T.-H.; Ahn, W.-Y.

10.1101/2021.02.17.431718 — neuroscience — Posted on 2021-02-18

1528 Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits

Yao, H. K.; Guet-McCreight, A.; Mazza, F.; Moradi Chameh, H.; Prevot, T. D.; Griffiths, J.; Tripathy, S. J.; Valiante, T. A.; Sibille, E.; Hay, E.

10.1101/2021.02.17.431698 — neuroscience — Posted on 2021-02-18

1529 Twitches emerge postnatally during quiet sleep in human infants and are synchronized with sleep spindles

Sokoloff, G.; Dooley, J. C.; Glanz, R. M.; Wen, R. Y.; Hickerson, M. M.; Evans, L. G.; Laughlin, H. M.; Apfelbaum, K. S.; Blumberg, M. S.

10.1101/2021.02.17.431688 — neuroscience — Posted on 2021-02-18

1530 Fasting reverses drug-resistance in hepatocellular carcinoma through p53-dependent metabolic synergism

Krstic, J.; Reinisch, I.; Schindlmaier, K.; Galhuber, M.; Berger, N.; Kupper, N.; Moyschewitz, E.; Auer, M.; Michenthaler, H.; Noessing, C.; Depaoli, M. R.; Ramadani-Muja, J.; Stryeck, S.; Pichler, M.; Rinner, B.; Deutsch, A. J.; Reinisch, A.; Madl, T.; Zenezini Chiozzi, R.; Heck, A. J.; Huch, M.; Malli, R.; Prokesch, A.

10.1101/2021.02.10.430545 — cancer biology — Posted on 2021-02-18

1531 On the sensitivity analysis of porous finite element models for cerebral perfusion estimation

Jozsa, T. I.; Padmos, R. M.; El-Bouri, W. K.; Hoekstra, A. G.; Payne, S. J.

10.1101/2021.02.18.431511 — biophysics — Posted on 2021-02-18

1532 Automated assignment of cell identity from single-cell multiplexed imaging and proteomic data

Geuenich, M. J.; Hou, J.; Lee, S.; Jackson, H. W.; Campbell, K. R.

10.1101/2021.02.17.431633 — bioinformatics — Posted on 2021-02-18

1533 Phagocytosed polyhedrin-cytokine co-crystal nanoparticles provide sustained secretion of bioactive cytokines from macrophages

Wendler, A.; James, N.; Jones, M.; Pernstich, C.

10.1101/2021.02.17.431660 — bioengineering — Posted on 2021-02-18

1534 Glycine receptor α3K governs mobility and conductance of L/K splice variant heteropentamers

Lemmens, V.; Thevelein, B.; Kankowski, S.; Mizuno, H.; Meier, J.; Rocha, S.; Brone, B.; Hendrix, J.

10.1101/2021.02.18.431627 — biochemistry — Posted on 2021-02-18

1535 How to reach a higher selection plateau with optimal contribution selection and compensatory mating?

Tiret, M.; Pegard, M.; Sanchez, L.

10.1101/2021.02.15.431233 — evolutionary biology — Posted on 2021-02-18

1536 Relict groups of spiny frogs indicate Late Paleogene-Early Neogene trans-Tibet dispersal of thermophile faunal elements

Hofmann, S.; Jablonski, D.; Litvinchuk, S.; Masroor, R.; Schmidt, J.

10.1101/2021.02.18.430751 — evolutionary biology — Posted on 2021-02-18

1537 Kinesin-6 Klp9 orchestrates spindle elongation by regulating microtubule sliding and growth

Krüger, L. K.; Gelin, M.; Ji, L.; Kikuti, C.; Houdusse, A.; Thery, M.; Blanchoin, L.; Tran, P.

10.1101/2021.02.17.431708 — cell biology — Posted on 2021-02-18

1538 Intra-ocular dendritic cells are increased in HLA-B27 associated acute anterior uveitis

Kasper, M.; Heming, M.; Schafflick, D.; Li, X.; Lautwein, T.; Meyer zu Horste, M.; Bauer, D.; Walscheid, K.; Wiendl, H.; Loser, K.; Heiligenhaus, A.; Meyer zu Hörste, G.

10.1101/2021.02.16.431370 — immunology — Posted on 2021-02-18

1539 Specific changes in sleep oscillations after blocking human metabotropic glutamate receptor 5 in the absence of altered memory function

Feld, G. B.; Bergmann, T. O.; Alzadeh-Asfestani, M.; Stuke, V.; Wriede, J.-P.; Soekadar, S.; Born, J.

10.1101/2020.07.24.219865 — neuroscience — Posted on 2021-02-18

1540 The underlying mechanisms of improved balance after one and ten sessions of balance training in older adults

Alizadehsaravi, L.; Koster, R. A. J.; Muijres, W.; Maas, H.; Bruijn, S. M.; van Dieen, J. H.

10.1101/2020.10.01.322313 — neuroscience — Posted on 2021-02-18

1541 Phase-based cortical synchrony is affected by prematurity

Yrjölä, P.; Stjerna, S.; Palva, J. M.; Vanhatalo, S.; Tokariev, A.

10.1101/2021.02.15.431226 — neuroscience — Posted on 2021-02-18

1542 Universal latent axes capturing Parkinson's patient deep phenotypic variation reveals patients with a high genetic risk for Alzheimer's disease are more likely to develop a more aggressive form of Parkinson's.

Sandor, C.; Millin, S.; Dahl, A.; Lawton, M.; Hubbard, L.; Bojovic, B.; Peyret-Guzzon, M.; Matten, H.; Blancher, C.; Williams, N.; Ben-Shlomo, Y.; Hu, M. T.; Grosset, D. G.; Marchini, J.; Webber, C.

10.1101/655217 — neuroscience — Posted on 2021-02-18

1543 Temporal enhancement of cross-adaptation between density and size perception based on the theory of magnitude

Hisakata, R.; Kaneko, H.

10.1101/2021.02.16.431522 — neuroscience — Posted on 2021-02-18

1544 MK-801-induced behavioral and dopaminergic responses in the shell part of the nucleus accumbens in adult rats are disrupted after neonatal blockade of the ventral subiculum.

Saoud, H.; Kereselidze, E.; Eybrard, S.; Louilot, A.

10.1101/2021.02.16.431488 — neuroscience — Posted on 2021-02-18

1545 Timing of selective basal ganglia white matter loss in Huntington's disease

Zeun, P.; McColgan, P.; Dhollander, T.; Gregory, S.; Johnson, E. B.; Papoutsi, M.; Nair, A.; Scahill, R. I.; Rees, G.; Tabrizi, S. J.

10.1101/2021.02.17.431568 — neuroscience — Posted on 2021-02-18

1546 A candidate neuroimaging biomarker for detection of neurotransmission-related functional alterations and prediction of pharmacological analgesic response in chronic pain

Martins, D.; Veronese, M.; Turkheimer, F. E.; Howard, M. A.; Williams, S. C.; Dipasquale, O.

10.1101/2021.02.17.431572 — neuroscience — Posted on 2021-02-18

1547 Characteristics of mathematical modeling languages that facilitate model reuse in systems biology: A software engineering perspective

Schölzel, C.; Blesius, V.; Ernst, G.; Dominik, A.

10.1101/2019.12.16.875260 — systems biology — Posted on 2021-02-18

1548 The PMT-driven p-coumaroylation of poplar lignins impacts lignin structure and improves wood saccharification

Lapierre, C.; Sibout, R.; Laurans, F.; Lesage-Descauses, M.-C.; Dejardin, A.; Pilate, G.

10.1101/2021.02.16.431462 — plant biology — Posted on 2021-02-18

1549 OMAmer: tree-driven and alignment-free protein assignment to subfamilies outperforms closest sequence approaches

Rossier, V.; Vesztrocy, A. W.; Robinson-Rechavi, M.; Dessimoz, C.

10.1101/2020.04.30.068296 — bioinformatics — Posted on 2021-02-18

1550 The type and source of reactive oxygen species influences the outcome of oxidative stress in cultured cells

Goffart, S.; Tikkanen, P.; Michell, C.; Wilson, T.; Pohjoismäki, J. L. O.

10.1101/2021.02.16.431512 — cell biology — Posted on 2021-02-18

1551 High-throughput and high-efficiency sample preparation for single-cell proteomics using a nested nanowell chip

Woo, J.; Williams, S. M.; Aguilera-Vazquez, V.; Sontag, R. L.; Moore, R. J.; Markillie, L. M.; Mehta, H. S.; Cantlon, J.; Adkins, J. N.; Smith, R. D.; Clair, G. C.; Pasa-Tolic, L.; Zhu, Y.

10.1101/2021.02.17.431689 — systems biology — Posted on 2021-02-18

1552 A genome-scale metabolic model of Saccharomyces cerevisiae that integrates expression constraints and reaction thermodynamics

Oftadeh, O.; Salvy, P.; Masid, M.; Curvat, M.; Miskovic, L.; Hatzimanikatis, V.

10.1101/2021.02.17.431671 — systems biology — Posted on 2021-02-18

1553 Singlet oxygen-dependent chloroplast degradation is independent of macroautophagy in the Arabidopsis ferrochelatase two mutant

Lemke, M. D.; Fisher, K. E.; Kozlowska, M. A.; Tano, D.; Woodson, J. D.

10.1101/2021.02.17.431731 — plant biology — Posted on 2021-02-18

1554 Chloroplast acquisition without the gene transfer in kleptoplastic sea slugs, Plakobranchus ocellatus

Maeda, T.; Takahashi, S.; Yoshida, T.; Shimamura, S.; Takaki, Y.; Nagai, Y.; Toyoda, A.; Suzuki, Y.; Arimoto, A.; Ishii, H.; Satoh, N.; Nishiyama, T.; Hasebe, M.; Maruyama, T.; Minagawa, J.; Obokata, J.; Shigenobu, S.

10.1101/2020.06.16.155838 — evolutionary biology — Posted on 2021-02-18

1555 A method to estimate effective population size from linkage disequilibrium when generations overlap

Garcia-Cortes, L. A.; Austerlitz, F.; R. de Cara, M. A.

10.1101/2021.02.17.431658 — evolutionary biology — Posted on 2021-02-18

1556 Plant responses to multiple antagonists are mediated by order of attack and phytohormone crosstalk

Basu, S.; Clark, R. E.; Bera, S.; Casteel, C. L.; Crowder, D. W.

10.1101/2021.02.17.431727 — ecology — Posted on 2021-02-18

1557 Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells

Cuevas-Velazquez, C. L.; Vellosillo, T.; Guadalupe, K.; Schmidt, H. B.; Yu, F.; Moses, D.; Brophy, J. A.; Cosio-Acosta, D.; Das, A.; Wang, L.; Jones, A. M.; Covarrubias, A. A.; Sukenik, S.; Dinneny, J. R.

10.1101/2021.02.17.431712 — cell biology — Posted on 2021-02-18

1558 Frequent intergenotypic recombination between the non-structural and structural genes is a major driver of epidemiological fitness in caliciviruses

Mahar, J. E.; Jenckel, M.; Huang, N.; Smertina, E.; Holmes, E. C.; Strive, T.; Hall, R.

10.1101/2021.02.17.431744 — microbiology — Posted on 2021-02-18

1559 Spatial modulation of individual behaviors enables collective decision-making during bacterial group migration

Bai, Y.; He, C.; Long, J.; Li, X.; Fu, X.

10.1101/2021.02.17.431709 — microbiology — Posted on 2021-02-18

1560 Herpes Simplex Virus Co-Infection Facilitates Rolling Circle Replication of the Adeno-Associated Virus Genome

Meier, A. F.; Tobler, K.; Leisi, R.; Lkharrazi, A.; Ros, C.; Fraefel, C.

10.1101/2020.12.23.424160 — microbiology — Posted on 2021-02-18

1561 Unifying the known and unknown microbial coding sequence space

Vanni, C.; Schechter, M. S.; Acinas, S.; Barberan, A.; Buttigieg, P. L.; Casamayor, E. O.; Delmont, T. O.; Duarte, C. M.; Eren, A. M.; Finn, R. D.; Kottmann, R.; Mitchell, A.; Sanchez, P.; Siren, K.; Steinegger, M.; Glöckner, F. O.; Fernandez-Guerra, A.

10.1101/2020.06.30.180448 — microbiology — Posted on 2021-02-18

1562 Talaromyces marneffei promotes M2 polarization of human macrophages by downregulating SOCS3 expression and activating TLR9 pathway

Wei, W.; Ning, C.; Huang, J.; Wang, G.; Lai, J.; Han, J.; Zang, N.; Liang, B.; Liao, Y.; Le, T.; Jiang, J.; Ye, L.; Liang, H.

10.1101/2021.02.17.431726 — microbiology — Posted on 2021-02-18

1563 Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave

Hohsfield, L. A.; Najafi, A. R.; Ghorbanian, Y.; Soni, N.; Crapser, J.; Figueroa Velez, D. X.; Jiang, S.; Royer, S. E.; Kim, S. J.; Anderson, A.; Gandhi, S. P.; Mortazavi, A.; Inlay, M. A.; Green, K. N.

10.1101/2021.02.17.431594 — immunology — Posted on 2021-02-18

1564 Functional cooperativity mediated by rationally selected combinations of human monoclonal antibodies targeting the henipavirus receptor binding protein

10.1101/2021.02.17.431743 — immunology — Posted on 2021-02-18

1565 Remyelination restores myelin content on distinct neuronal subtypes in the cerebral cortex

Call, C. L.; Bergles, D. E.

10.1101/2021.02.17.431685 — neuroscience — Posted on 2021-02-18

1566 Heparan Sulfated Glypican-4 is Released from Astrocytes Predominantly by Proteolytic Shedding

Huang, K.; Park, S.

10.1101/2021.02.17.431702 — neuroscience — Posted on 2021-02-18

1567 Impaired pattern separation in Tg2576 mice is associated with hyperexcitable dentate gyrus caused by Kv4.1 downregulation

Kim, K.-R.; Kim, Y.; Jeong, H.-j.; Kang, J.-S.; Lee, S. H.; Kim, Y.; Lee, S.-H.; Ho, W.-K.

10.1101/2021.02.17.431569 — neuroscience — Posted on 2021-02-18

1568 FRAGMENTED BIODIVERSITY: FERNS AND LYCOPHYTES FROM FOREST FRAGMENTS IN JUIZ DE FORA, MINAS GERAIS, BRAZIL

Lima, L. V.; Dittrich, V. A.; Souza, F. S.; Fonseca, C. R.

10.1101/2021.02.17.431701 — plant biology — Posted on 2021-02-18

1569 Hot days are associated with short-term adrenocortical responses in a Southern African arid-zone passerine bird.

Moagi, L. L.; Bourne, A. R.; Cunningham, S. J.; Jansen, R.; Ngcamphalala, C. A.; Ridley, A. R.; McKechnie, A. E.

10.1101/2021.02.17.431578 — physiology — Posted on 2021-02-18

1570 Pharmacological inhibition of PAI-1 alleviates cardiopulmonary pathologies induced by exposure to air pollutants PM2.5

Ghosh, A. K.; Soberanes, S.; Lux, E.; Shang, M.; Piseaux Aillon, R.; Eren, M.; Budinger, G. R. S.; Miyata, T.; Vaughan, D. E.

10.1101/2021.02.17.431681 — pharmacology and toxicology — Posted on 2021-02-18

1571 Phospholipid membrane formation templated by coacervatedroplets

Pir Cakmak, F.; Marianelli, A. M.; Keating, C. D.

10.1101/2021.02.17.431720 — biophysics — Posted on 2021-02-18

1572 Surface Densities Prewet a Near-Critical Membrane

Rouches, M.; Veatch, S.; Machta, B.

10.1101/2021.02.17.431700 — biophysics — Posted on 2021-02-18

1573 Weighted force analysis method for derivation of multidimensional free energy landscapes from adaptively-biased replica simulations

Marinelli, F.; Faraldo-Gomez, J.

10.1101/2021.02.17.431654 — biophysics — Posted on 2021-02-18

1574 Spatiotemporal organization of chromatin domains: role of interaction energy and polymer entropy

Kumari, K.; Jagadeeshan, R. P.; Padinhateeri, R.

10.1101/2021.02.17.431616 — biophysics — Posted on 2021-02-18

1575 Predicting Dengue Fever in Brazilian Cities

Roster, K.; Connaughton, C.; Rodrigues, F. A.

10.1101/2021.02.17.430949 — bioinformatics — Posted on 2021-02-18

1576 An integral genomic signature approach for tailored cancer targeted therapy using genome-wide sequencing data

wang, x.; Lee, S.; Tang, G.; Wang, Y.

10.1101/2021.02.17.431663 — bioinformatics — Posted on 2021-02-18

1577 Chromatin accessibility regulates intron retention in a cell type-specific manner

Petrova, V.; Song, R.; DEEP Consortium, ; Nordstrom, K. J. V.; Walter, J.; Wong, J. J.- L.; Armstrong, N. J.; Rasko, J. J. E.; Schmitz, U.

10.1101/2021.02.17.431609 — bioinformatics — Posted on 2021-02-18

1578 Structural effects driven by rare point mutations in amylin hormone, the type II diabetes associated peptide

Mendes, W. S.; Franco, O. L.; Alencar, S. A.; Porto, W. F.

10.1101/2021.02.17.431675 — bioinformatics — Posted on 2021-02-18

1579 Evidences for functional trans-acting eRNA-promoter R-loops at Alu sequences

Bai, X.; Li, F.; Zhang, Z.

10.1101/2021.02.17.431596 — bioinformatics — Posted on 2021-02-18

1580 coupleCoC+: an information-theoretic co-clustering-basedtransfer learning framework for the integrative analysis of single-cell genomic data

ZENG, P.; Lin, Z.

10.1101/2021.02.17.431728 — bioinformatics — Posted on 2021-02-18

1581 A Programmable Toolkit to Dynamically Signal Cells using Peptide Strand Displacement

Riker, K.; Daly, M. L.; Papanikolas, M.; Jian, T.; Klawa, S. J.; Sahin, J. S.; Liu, D.; Singh, A.; Miller, A. G.; Freeman, R.

10.1101/2021.02.17.431719 — bioengineering — Posted on 2021-02-18

1582 Bioengineering of genetically encoded gene promoter repressed by flavonoids for constructing intracellular sensor for molecular events

Desmet, N. M.; Dhusia, K.; Qi, W.; Doseff, A. I.; Bhattacharya, S.; Gilad, A.

10.1101/2021.02.17.431641 — bioengineering — Posted on 2021-02-18

1583 Quantifying Viscous Damping and Stiffness in Parkinsonism Using Data-Driven Model Estimation

Werning, A.; Umbarila, D.; Fite, M.; Fergus, S.; Zhang, J.; Molnar, G. F.; Johnson, L. A.; Wang, J.; Vitek, J. L.; Escobar Sanabria, D.

10.1101/2021.02.17.431730 — bioengineering — Posted on 2021-02-18

1584 Capturing actively produced microbial volatile organic compounds from human associated samples with vacuum assisted sorbent extraction

Phan, J.; Kapcia, J.; Rodriguez, C. I.; Vogel, V. L.; Dunham, S. J. B.; Whiteson, K.

10.1101/2021.02.16.431476 — biochemistry — Posted on 2021-02-18

1585 Doublecortin engages the microtubule lattice through a cooperative binding mode involving its C- terminal domain

Rafiei, A.; Lee, L.; Crowder, D. A.; Saltzberg, D. J.; Sali, A.; Brouhard, G.; Schriemer, D. C.

10.1101/2021.02.17.431714 — biochemistry — Posted on 2021-02-18

1586 ATLASx: a computational map for the exploration of biochemical space

Mohammadi-Peyhani, H.; Hafner, J.; Sveshnikova, A.; Viterbo, V.; Hatzimanikatis, V.

10.1101/2021.02.17.431583 — biochemistry — Posted on 2021-02-18

1587 Genomic architecture of 5S rDNA cluster and its variations within and between species

Ding, Q.; Li, R.; Ren, X.; Chan, L.-y.; Ho, V. W.; Xie, D.; Ye, P.; Zhao, Z.

10.1101/2021.02.17.431734 — genomics — Posted on 2021-02-18

1588 Non-destructive extraction of DNA from preserved tissues in medical collections

Rayo, E.; Ferrari, G.; Neukamm, J.; Akgül, G.; Breidenstein, A. M.; Cooke, M.; Phillips, C.; Bouwman, A. S.; Rühli, F. J.; Schünemann, V. J.

10.1101/2021.02.17.431618 — genetics — Posted on 2021-02-18

1589 Compression for population genetic datathrough finite-state entropy

Chen, W.; Elliott, L. T.

10.1101/2021.02.17.431713 — genetics — Posted on 2021-02-18

1590 Third Backcross Generation Indonesian Indigenous Chicken Kampong Broiler-Type (Kambro) SOX5 Gene Polymorphism

Ardo, T.; Perdamaian, A. B. I.; Mahardhika, I. W. S.; Daryono, B. S.

10.1101/2021.02.17.431737 — genetics — Posted on 2021-02-18

1591 Dopamine receptor DOP-1 engages a sleep pathway to modulate swimming in C. elegans

Xu, Y.; Zhang, L.; Liu, Y.; Topalidou, I.; Hassinan, C.; Ailion, M.; Zhao, Z.; Wang, T.; Chen, Z.; Bai, J.

10.1101/2021.02.17.431715 — genetics — Posted on 2021-02-18

1592 Large genetic diversity and strong positive selection in F-box and GPCR genes among the wild isolates of Caenorhabditis elegans

Ma, F.; Lau, C. Y.; Zheng, C.

10.1101/2020.07.09.194670 — evolutionary biology — Posted on 2021-02-17

1593 Testing hypotheses of marsupial brain size variation using phylogenetic multiple imputations and a Bayesian comparative framework

Todorov, O. S.; Blomberg, S. P.; Goswami, A.; Sears, K.; Drhlik, P.; Peters, J.; Weisbecker, V.

10.1101/2021.02.17.431536 — evolutionary biology — Posted on 2021-02-18

1594 The frequency and topology of pseudoorthologs

Smith, M. L.; Hahn, M. W.

10.1101/2021.02.17.431499 — evolutionary biology — Posted on 2021-02-18

1595 Association between land use and composition of amphibian species in temperate Brazilian forest remnants

dos Santos, R. C.; Dalmolin, D. A.; Brum, D.; Lucas, E. M.; Tozetti, A. M.

10.1101/2021.02.17.431642 — ecology — Posted on 2021-02-18

1596 Climate change shifts abiotic niche of temperate skates towards deeper zones in the Southwestern Atlantic Ocean

Coelho, J. F. R.; Lima, S. M. Q.; Petean, F. F.

10.1101/2021.02.17.431632 — ecology — Posted on 2021-02-18

1597 Skillful prediction of tropical Pacific fisheries provided by Atlantic Ninos

Gomara, I.; Rodriguez-Fonseca, B.; Mohino, E.; Losada, T.; Polo, I.; Coll, M.

10.1101/2021.02.17.431587 — ecology — Posted on 2021-02-18

1598 Humans hastened the range collapse and extinction of woolly mammoth

Fordham, D. A.; Brown, S. C.; Akcakaya, H. R.; Brook, B. W.; Haythorne, S.; Manica, A.; Shoemaker, K. T.; Austin, J. J.; Blonder, B.; Pilowsky, J.; Rahbek, C.; Nogues-Bravo, D.

10.1101/2021.02.17.431706 — ecology — Posted on 2021-02-18

1599 Ex vivo anticoagulants affect the mechanical properties of human blood platelets with implications for in vitro high-throughput functional mechanophenotyping.

Sachs, L.; Wesche, J.; Lenkeit, L.; Greinacher, A.; Bender, M.; Otto, O.; Palankar, R.

10.1101/2021.02.17.428074 — cell biology — Posted on 2021-02-18

1600 Human breast milk enhances intestinal mucosal barrier function and innate immunity in a pediatric human enteroid model

Noel, G.; In, J.; Lemme-Dumit, J. M.; DeVine, L. R.; Cole, R. N.; Guerrerio, A. L.; Kovbasnjuk, O.; Pasetti, M. F.

10.1101/2021.02.17.431653 — immunology — Posted on 2021-02-18

1601 Goal-Driven Recurrent Neural Network Models of the Ventral Visual Stream

Nayebi, A.; Sagastuy-Brena, J.; Bear, D. M.; Kar, K.; Kubilius, J.; Ganguli, S.; Sussillo, D.; DiCarlo, J. J.; Yamins, D. L. K.

10.1101/2021.02.17.431717 — neuroscience — Posted on 2021-02-18

1602 Soil respiration variation along an altitudinal gradient in Italian Alps: Disentangling forest structure and temperature effects

Montagnani, L.; Badraghi, A.; Ventura, M.; Polo, A.; Borruso, L.

10.1101/2021.02.17.431600 — ecology — Posted on 2021-02-17

1603 The IL-10GFP (VeRT-X) mouse strain is not suitable for the detection of IL-10 production by granulocytes during lung inflammation

Özkan, M.; Eskiocak, Y. C.; Wingender, G.

10.1101/2021.02.17.431604 — immunology — Posted on 2021-02-17

1604 Midbrain dopamine neurons provide teaching signals for goal-directed navigation

Farrell, K.; Lak, A.; Saleem, A. B.

10.1101/2021.02.17.431585 — neuroscience — Posted on 2021-02-17

1605 Stink bug Agonoscelis spp. (Heteroptera: Pentatomidae)-An Emerging Threat for Seed Production in Alfalfa Crop (Medicago sativa L.) and Their Successful Management

Bashir, M. A.

10.1101/2021.02.17.431601 — zoology — Posted on 2021-02-17

1606 Invariant Differential Expression Analysis Reveals Mechanism of Cancer Resistance to Cell Cycle Inhibitors

Chatterjee, A.; Pandey, S.; Danda, R.; Kumar R, R.; S, M.; Khetan, V.; Rishi, P.; S, R.; Elchuri, S. V.; Sahoo, D.

10.1101/2021.02.17.431607 — systems biology — Posted on 2021-02-17

1607 Dynamic Methylome Modification associated with mutational signatures in ageing and etiology of disease

Kumar, G.; Krishnasamy, K.; Pasha, N.; Nagarajan, N.; Mam, B.; Kishinani, M.; Vohra, V.; Jain, R.; Morawala Patell, V.

10.1101/2020.12.22.423778 — genomics — Posted on 2021-02-17

1608 Genetic variation among wMel strains of Wolbachia pipientis differentially rescues a bag of marbles partial loss of function mutant in Drosophila melanogaster

Bubnell, J. E.; Ulbing, C. K.; Fernandez Begne, P.; Aquadro, C. F.

10.1101/2021.01.15.426050 — genetics — Posted on 2021-02-17

1609 Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells

Le Vasseur, M.; Friedman, J. R.; Jost, M.; Xu, J.; Yamada, J.; Kampmann, M.; Horlbeck, M. A.; Salemi, M. R.; Phinney, B. S.; Weissman, J. S.; Nunnari, J.

10.1101/2021.02.16.431450 — cell biology — Posted on 2021-02-17

1610 3D stochastic simulation of chemoattractant-mediated excitability in cells

Biswas, D.; Devreotes, P. N.; Iglesias, P. A.

10.1101/2021.02.17.431608 — cell biology — Posted on 2021-02-17

1611 A unified physiological framework of transitions between seizures, sustained ictal activity, and depolarization block at the single neuron level

Depannemaecker, D.; Ivanov, A.; Lillo, D.; Spek, L.; Bernard, C.; Jirsa, V.

10.1101/2020.10.23.352021 — neuroscience — Posted on 2021-02-17

1612 A transient postnatal quiescent period precedes emergence of mature cortical dynamics

Dominguez, S.; Ma, L.; Yu, H.; Pouchelon, G.; Mayer, C.; Spyropoulos, G. D.; Cea, C.; Buzsaki, G.; Fishell, G.; Khodagholy, D.; Gelinas, J. N.

10.1101/2021.02.17.430487 — neuroscience — Posted on 2021-02-17

1613 Shared functional connections within and between cortical networks predict individual cognitive abilities in males and females

Dhamala, E.; Jamison, K. W.; Jaywant, A.; Kuceyeski, A.

10.1101/2021.02.17.431670 — neuroscience — Posted on 2021-02-17

1614 Visual neuroscience methods for marmosets: efficient receptive field mapping and head-free eye tracking

Jendritza, P.; Klein, F. J.; Rohenkohl, G.; Fries, P.

10.1101/2020.10.30.361238 — neuroscience — Posted on 2021-02-17

1615 Cell-type specific arousal-dependent modulation of thalamic activity in the lateral geniculate nucleus

Molnar, B.; Sere, P.; Borde, S.; Koos, K.; Horvat, P.; Lorincz, M. L.

10.1101/2021.02.17.431649 — neuroscience — Posted on 2021-02-17

1616 FMRP sustains presynaptic function via control of activity-dependent bulk endocytosis

Bonnycastle, K.; Kind, P. C.; Cousin, M. A.

10.1101/2020.09.10.291062 — neuroscience — Posted on 2021-02-17

1617 Visual perception of texture regularity: conjoint measurements and a wavelet response-distribution model

Sun, H.-C.; Baker, C. L.; Kingdom, F. A. A.; St-Amand, D.

10.1101/2021.02.17.431605 — neuroscience — Posted on 2021-02-17

1618 Music-selective neural populations arise without musical training

Boebinger, D. L.; Norman-Haignere, S. V.; McDermott, J. H.; Kanwisher, N.

10.1101/2020.01.10.902189 — neuroscience — Posted on 2021-02-17

1619 Accumulation of somatic mutations leads to genetic mosaicism in Cannabis

Adamek, K.; Torkamaneh, D.; Jones, A. M. P.

10.1101/2021.02.11.430823 — plant biology — Posted on 2021-02-17

1620 Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: the Multi-Targeting Drug DREAM Challenge

Xiong, Z.; Jeon, M.; Allaway, R. J.; Kang, J.; Park, D.; Lee, J.; Jeon, H.; Ko, M.; Jiang, H.; Zheng, M.; Tan, A. C.; Guo, X.; The Multi-Targeting Drug DREAM Challenge Community, ; Dang, K. K.; Tropsha, A.; Hecht, C.; Das, T. K.; Carlson, H. A.; Abagyan, R.; Guinney, J.; Schlessinger, A.; Cagan, R.

10.1101/2021.02.15.430538 — pharmacology and toxicology — Posted on 2021-02-17

1621 Time Trend, Social Vulnerability, and Identification of Risk Areas for Tuberculosis in Brazil: an Ecological Study

DE paiva, J. P. S.; Magalhaes, M. A. F. M.; LEAL, T. c.; DA SILVA, L. F.; DA SILVA, L. G.; DO CARMO, R. F.; Souza, C. D. F.

10.1101/2021.02.17.431602 — pathology — Posted on 2021-02-17

1622 Gene expression profiling of skeletal muscles

Alto, S. I.; Chang, C.-N.; Brown, K.; Kioussi, C.; Filtz, T. M.

10.1101/2021.02.17.431599 — bioinformatics — Posted on 2021-02-17

1623 Measuring the unknown: an estimator and simulation study for assessing case reporting during epidemics

Jarvis, C.; Gimma, A.; Finger, F.; Morris, T.; Thompson, J.; le Polain de Warroux, O.; Edmunds, J.; Funk, S.; Jombart, T.

10.1101/2021.02.17.431606 — bioinformatics — Posted on 2021-02-17

1624 Identification of differentially distributed gene expression and distinct sets of cancer-related genes identified by changes in expression mean and variability

Roberts, A. G. K.; Catchpoole, D. R.; Kennedy, P. J.

10.1101/2021.02.15.431343 — genomics — Posted on 2021-02-17

1625 Chromosome-length genome assembly and structural variations of the primal Basenji dog (Canis lupus familiaris) genome

10.1101/2020.11.11.379073 — genomics — Posted on 2021-02-17

1626 Analysis of paralogs in target enrichment data pinpoints multiple ancient polyploidy events in Alchemilla s.l. (Rosaceae)

Morales-Briones, D. F.; Gehrke, B.; Huang, C.-H.; Liston, A.; Ma, H.; Marx, H. E.; Tank, D. C.; Yang, Y.

10.1101/2020.08.21.261925 — evolutionary biology — Posted on 2021-02-17

1627 Taking fright: the decline of Australian Pied Oystercatchers Haematopus longirostris at South Ballina Beach, New South Wales

Totterman, S.

10.1101/2020.06.09.141796 — ecology — Posted on 2021-02-17

1628 GATA3 is essential for separating patterning domains during facial morphogenesis

Abe, M.; Firulli, A. B.; Kanai, S. M.; Limi, K.-C.; Engel, J. D.; Clouthier, D. E.

10.1101/2021.02.17.431667 — developmental biology — Posted on 2021-02-17

1629 Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures

Rausser, S.; Trumpff, C.; McGill, M. A.; Junker, A.; Wang, W.; Ho, S.-H.; Mitchell, A.; Karan, K. R.; Monk, C.; Segerstrom, S. C.; Reed, R. G.; Picard, M.

10.1101/2020.10.16.342923 — cell biology — Posted on 2021-02-17

1630 Heterogenous susceptibility to R-pyocin killing in populations of Pseudomonas aeruginosa sourced from cystic fibrosis lungs

Mei, M.; Thomas, J.; Diggle, S. P.

10.1101/2020.08.05.238956 — microbiology — Posted on 2021-02-17

1631 Wolbachia-conferred antiviral protection is determined by developmental temperature

Chrostek, E.; Martins, N. E.; Marialva, M. S.; Teixeira, L.

10.1101/2020.06.24.169169 — microbiology — Posted on 2021-02-17

1632 Molecular characterization of vancomycin-resistant Enterococcus faecium isolates collected from the Dallas, Texas area

Islam, M.; Abaragu, A.; Sistu, H.; Akins, R. L.; Palmer, K. L.

10.1101/2021.02.16.431552 — microbiology — Posted on 2021-02-17

1633 Auditory Stimulus-response Modeling with a Match-Mismatch Task

de Cheveigne, A.; Slaney, M.; Hjortkjaer, J.; Fuglsang, S.

10.1101/2020.11.05.370072 — neuroscience — Posted on 2021-02-17

1634 Dynamic predictive coding across the left fronto-temporal language hierarchy: Evidence from MEG, EEG and fMRI

Wang, L.; Schoot, L.; Brothers, T.; Alexander, E.; Warnke, L.; Kim, M.; Khan, S.; Hamalainen, M.; Kuperberg, G.

10.1101/2021.02.17.431452 — neuroscience — Posted on 2021-02-17

1635 The Need for Sustainable Leadership in Academia - a German Case Study

Haage, V. C.; Voss, L.; Nguyen, D.; Eggert, F.

10.1101/2021.02.17.431650 — scientific communication and education — Posted on 2021-02-17

1636 Tetrazoles as PPARγ ligands: Structural and Computational Investigation.

de Paul, K.; dos Santos, J. C.; Mafud, A. C.; Nascimento, A. S.

10.1101/2021.02.17.431624 — biophysics — Posted on 2021-02-17

1637 Predators affect a plant virus through direct and trait-mediated indirect effects on vectors

Lee, B. W.; Clark, R. E.; Basu, S.; Crowder, D.

10.1101/2021.02.17.431666 — ecology — Posted on 2021-02-17

1638 The Amyloid Precursor Protein regulates human cortical neurogenesis

Shabani, K.; Pigeon, J.; Benaissa Touil Zariouh, M.; Liu, T.; Saffarian, A.; Komatsu, J.; Liu, E.; Danda, N.; Limame, R.; Bohl, D.; Parras, C.; Hassan, B. A.

10.1101/2021.02.17.431707 — developmental biology — Posted on 2021-02-17

1639 Potent neutralization antibodies induced by a recombinant trimeric Spike protein vaccine candidate containing PIKA adjuvant for COVID-19

Tong, J.; Zhu, C.; Lai, H.; Feng, C.; Zhou, D.

10.1101/2021.02.17.431647 — immunology — Posted on 2021-02-17

1640 Broadly reactive human monoclonal antibodies targeting the pneumococcal histidine triad protein protect against fatal pneumococcal infection

Huang, J.; Gingerich, A. D.; Royer, F.; Paschall, A. V.; Pena-Briseno, A.; Avci, F. Y.; Mousa, J. J.

10.1101/2021.02.17.431651 — immunology — Posted on 2021-02-17

1641 Targeting Diacylglycerol Lipase to Reduce AlcoholConsumption

Bedse, G.; Winters, N. D.; Astafyev, A.; Patrick, T. A.; Mahajan, V. R.; Uddin, M. J.; Centanni, S. W.; Samuels, D. C.; Marnett, L. J.; Winder, D. G.; Patel, S.

10.1101/2021.02.16.431429 — neuroscience — Posted on 2021-02-17

1642 Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo

Shao, L.-X.; Liao, C.; Gregg, I.; Savalia, N.; Delagarza, K.; Kwan, A. C.

10.1101/2021.02.17.431629 — neuroscience — Posted on 2021-02-17

1643 Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing translation inhibition.

Panzhinskiy, E.; Skovso, S.; Cen, H. H.; Chu, K. Y.; MacDonald, K.; Soukhatcheva, G.; Dionne, D. A.; Hallmaier-Wacker, L. K.; Wildi, J. S.; Marcil, S.; Noursadeghi, N.; Taghizadeh, F.; Verchere, C. B.; Jan, E.; Johnson, J. D.

10.1101/2021.02.17.431676 — physiology — Posted on 2021-02-17

1644 The Serine Protease HtrA2 mediates radiation-induced senescence in cancer cells

Hammer, L.; Levin-Salomon, V.; Yaeli-Slonim, N.; Weiss, M.; Dekel-Bird, N. P.; Olender, T.; Porat, Z.; Winograd-Katz, S.; Savidor, A.; Levin, Y.; Bialik, S.; Geiger, B.; Kimchi, A.

10.1101/2021.02.17.431668 — cancer biology — Posted on 2021-02-17

1645 Phagocytosed polyhedrin-cytokine co-crystal nanoparticles provide sustained secretion of bioactive cytokines from macrophages

Wendler, A.; James, N.; Jones, M.; Pernstich, C.

10.1101/2021.02.17.431660 — bioengineering — Posted on 2021-02-17

1646 Traditional use of Cissampelos pareira L. for hormone disorder and fever provides molecular links of ESR1 modulation to viral inhibition

Haider, M.; Dholakia, D.; Panwar, A.; Garg, P.; Anand, V.; Gheware, A. P.; Singhal, K.; Singh, D.; Burse, S. A.; Enayathullah, M. G.; Parekh, Y.; Ram, S.; Kumari, S.; Kumar, A.; Ray, A.; Medigeshi, G. R.; Bokara, K. K.; Sharma, U.; Prasher, B.; Mukerji, M.

10.1101/2021.02.17.431579 — genomics — Posted on 2021-02-17

1647 A draft genome of Alliaria petiolata (garlic mustard) as a model system for invasion genetics

Alabi, N.; Wu, Y.; Bossdorf, O.; Rieseberg, L. H.; Colautti, R. I.

10.1101/2021.02.17.431678 — genomics — Posted on 2021-02-17

1648 Stony Coral Tissue Loss Disease biomarker bacteria identified in corals and overlying waters using a rapid field-based sequencing approach

Becker, C. C.; Brandt, M.; Miller, C.; Apprill, A.

10.1101/2021.02.17.431614 — microbiology — Posted on 2021-02-17

1649 Mechanical stress determines morphogenesis and cell ordering in confined bacterial biofilms

Zhang, Q.; Li, J.; Nijjer, J.; Lu, H.; Kothari, M.; Alert, R.; Cohen, T.; Yan, J.

10.1101/2021.02.17.431682 — microbiology — Posted on 2021-02-17

1650 The MS remyelinating drug bexarotene (an RXR agonist) promotes induction of human Tregs and suppresses Th17 differentiation in vitro

Gaunt, C. M.; Rainbow, D.; MacKenzie, R.; Jarvis, L.; Mousa, H.; Cunniffe, N.; Georgieva, Z.; Brown, W.; Coles, A.; Jones, J. L.

10.1101/2021.02.17.431344 — immunology — Posted on 2021-02-17

1651 Epitranscriptomic Dysregulation in Stress-induced Psychopathologies

Wang, D. O.; Joshi, K.; Gururajan, A.

10.1101/2021.02.17.431575 — neuroscience — Posted on 2021-02-17

1652 Diversity and Function of Motile Ciliated Cell Types within Ependymal Lineages of the Zebrafish Brain

D'Gama, P. P.; Qiu, T.; Cosacak, M. I.; Chong, Y. L.; Konac, A.; Hansen, J. N.; Ringers, C.; Hui, S. P.; Olstad, E. W.; Ng, C. P.; Rayamajhi, D.; Wachten, D. N.; Liebl, D.; Kikuchi, K.; Kizil, C.; Yaksi, E.; Roy, S.; Jurisch-Yaksi, N.

10.1101/2021.02.17.431442 — neuroscience — Posted on 2021-02-17

1653 Affinity Requirements For Control Of Synaptic Targeting And Neuronal Cell Survival By Heterophilic IgSF Cell Adhesion Molecules

Xu, S.; Sergeeva, A. P.; Katsamba, P. S.; Mannepalli, S.; Bahna, F.; Bimela, J.; Zipursky, L. S.; Shapiro, L.; Honig, B.; Zinn, K.

10.1101/2021.02.16.431482 — neuroscience — Posted on 2021-02-17

1654 Escherichia coli robustly expresses ATP synthase at growth rate maximizing concentrations

Rabbers, I.; Bruggeman, F. J.

10.1101/2021.02.17.431610 — systems biology — Posted on 2021-02-17

1655 Ezh2 as an epigenetic checkpoint regulator during monocyte differentiation: a potential target to improve cardiac repair after myocardial infarction

Rondeaux, J.; Groussard, D.; Renet, S.; Tardif, V.; Dumesnil, A.; Chu, A.; Henry, J.-P.; Badji, Z.; Claire, V.; Beziau, D.; Guerrot, D.; Brand, M.; Richard, V.; Durand, E.; Brakenhielm, E.; Fraineau, S.

10.1101/2021.02.17.428828 — physiology — Posted on 2021-02-17

1656 Gram-negative outer membrane proteins with multiple β-barrel domains

Solan, R.; Pereira, J.; Lupas, A. N.; Kolodny, R.; Ben-Tal, N.

10.1101/2021.02.17.431615 — biophysics — Posted on 2021-02-17

1657 Phase transitions may explain why SARS-CoV-2 spreads so fast and why new variants are spreading faster

Phillips, J. C.; Moret, M.; Zebende, G. F.; Chow, C. C.

10.1101/2021.02.16.431437 — biophysics — Posted on 2021-02-17

1658 How the replication and transcription complex of SARS-CoV-2 functions in leader-to-body fusion

Li, X.; Zhao, Q.; Chang, J.; Duan, G.; Bei, J.; Yau, T. O.; Yang, J.; Ruan, J.; He, B.; Shan, G.

10.1101/2021.02.17.431652 — bioinformatics — Posted on 2021-02-17

1659 Multiple Sites on SARS-CoV-2 Spike Protein are Susceptible to Proteolysis by Cathepsins B, K, L, S, and V

Bollavaram, K.; Leeman, T.; Kulkarni, A.; Upshaw, S.; Lee, M.; Yang, J.; Song, H.; Platt, M. O.

10.1101/2021.02.17.431617 — bioengineering — Posted on 2021-02-17

1660 Structural basis for the specificity of PPM1H phosphatase for Rab GTPases

Waschbüsch, D.; Berndsen, K.; Knebel, A.; Alessi, D. R.; Khan, A. R.

10.1101/2021.02.17.431620 — biochemistry — Posted on 2021-02-17

1661 A cell atlas of chromatin accessibility across 25 adult human tissues

Zhang, K.; Hocker, J. D.; Miller, M.; Hou, X.; Chiou, J.; Poirion, O. B.; Qiu, Y.; Li, Y. E.; Gaulton, K. J.; Wang, A.; Preissl, S.; Ren, B.

10.1101/2021.02.17.431699 — genomics — Posted on 2021-02-17

1662 A comprehensive fitness landscape model reveals the evolutionary history and future evolvability of eukaryotic cis-regulatory DNA sequences

Vaishnav, E. D.; de Boer, C. G.; Yassour, M.; Molinet, J.; Fan, L.; Adiconis, X.; Thompson, D. A.; Cubillos, F. A.; Levin, J. Z.; Regev, A.

10.1101/2021.02.17.430503 — genomics — Posted on 2021-02-17

1663 A rigorous framework for detecting SARS-CoV-2 spike protein mutational ensemble from genomic and structural features

Fatihi, S.; Rathore, S.; Pathak, A.; Gahlot, D.; Mukerji, M.; Jatana, N.; Thukral, L.

10.1101/2021.02.17.431625 — genomics — Posted on 2021-02-17

1664 Pak1 kinase regulates ribonucleoprotein granules through Sts5 for polarized growth and the glucose starvation response

Magliozzi, J. O.; Moseley, J. B.

10.1101/2021.02.17.431635 — cell biology — Posted on 2021-02-17

1665 HES1 protein oscillations are necessary for neural stem cells to exit from quiescence

Marinopoulou, E.; Sabherwal, N.; Biga, V.; Desai, J.; Adamson, A. D.; Papalopulu, N.

10.1101/2021.02.17.431655 — cell biology — Posted on 2021-02-17

1666 Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

Yuan, M.; Huang, D.; Lee, C.-C. D.; Wu, N. C.; Jackson, A. M.; Zhu, X.; Liu, H.; Peng, L.; van Gils, M. J.; Sanders, R. W.; Burton, D. R.; Reincke, S. M.; Prüss, H.; Kreye, J.; Nemazee, D.; Ward, A. B.; Wilson, I. A.

10.1101/2021.02.16.430500 — microbiology — Posted on 2021-02-17

1667 Eliciting a potent antitumor immune response by expressing tumor antigens in a skin commensal

Chen, Y. E.; Atabakhsh, K.; Dimas, A.; Nagashima, K.; Fischbach, M. A.

10.1101/2021.02.17.431662 — microbiology — Posted on 2021-02-17

1668 SARS-CoV-2 vaccination induces neutralizing antibodies against pandemic and pre-emergent SARS-related coronaviruses in monkeys

Saunders, K. O.; Lee, E.; Parks, R.; Martinez, D. R.; Li, D.; Chen, H.; Edwards, R. J.; Gobeil, S. M. C.; Barr, M.; Mansouri, K.; Alam, S. M.; Sutherland, L. L.; Cai, F.; Sanzone, A.; Berry, M.; Manne, K.; Kapingidza, A. B.; Azoitei, M.; Tse, L. V.; Scobey, T. D.; Spreng, R.; Rountree, R. W.; DeMarco, C. T.; Denny, T. N.; Woods, C. W.; Petzold, E. W.; Oguin, T. H.; Sempowski, G. D.; Gagne, M.; Douek, D. C.; Tomai, M. A.; Fox, C. B.; Seder, R.; Wiehe, K.; Weissman, D.; Pardi, N.; Acharya, P.; Andersen, H.; Lewis, M. G.; Moore, I. N.; Montefiori, D. C.; Baric, R. S.; Haynes, B. F.

10.1101/2021.02.17.431492 — immunology — Posted on 2021-02-17

1669 Delayed induction of type I and III interferons and nasal epithelial cell permissiveness to SARS-CoV-2

Hatton, C. F.; Botting, R. A.; Duenas, M. E.; Haq, I. J.; Verdon, B.; Thompson, B. J.; Stremenova Spegarova, J.; Gothe, F.; Stephenson, E. A.; Gardner, A. I.; Murphy, S.; Scott, J.; Garnett, J. P.; Carrie, S.; Hussain, R.; Coxhead, J.; Davey, T.; Simpson, J.; Haniffa, M.; Hambleton, S.; Brodlie, M.; Ward, C.; Trost, M.; Reynolds, G.; Duncan, C. J. A.

10.1101/2021.02.17.431591 — immunology — Posted on 2021-02-17

1670 Phospholipid peroxidation fuels ExoU phospholipase-dependent cell necrosis and supports Pseudomonas aeruginosa-driven pathology

Bagayoko, S.; Leon-Icaza, S.-A.; Pinilla, M.; Hessel, A.; Santoni, K.; Bordignon, P.-J.; Moreau, F.; Eren, E.; Boyance, A.; Naser, E.; Lefevre, L.; Berrone, C.; Iacobachvili, N.; Metais, A.; Rombouts, Y.; Coste, A.; Attree, I.; Frank, D. W.; Clevers, H.; Peters, P. J.; Cougoule, C.; Planes, R.; Meunier, E.

10.1101/2021.02.17.431580 — immunology — Posted on 2021-02-17

1671 Systemic administration of Ivabradine, an HCN channel inhibitor, blocks spontaneous absence seizures

Iacone, Y.; Morais, T. P.; David, F.; Delicata, F.; Sandle, J.; Raffai, T.; Parri, R.; Weisser, J. J.; Bundgaard, C.; Klewe, I. V.; Tamas, G.; Thomsen, M. S.; Crunelli, V.; Lorincz, M. L.

10.1101/2021.02.17.431588 — neuroscience — Posted on 2021-02-17

1672 Improved exercise anaerobic power and less central fatigue in CD73 knockout mice

Aguiar, A. S.; Speck, A. E.; Canas, P.; Cunha, R.

10.1101/2021.02.17.431631 — neuroscience — Posted on 2021-02-17

1673 The role of genus and life span in predicting seed and vegetative trait variation and correlation in Lathyrus, Phaseolus, and Vicia (Fabaceae)

Herron, S. A.; Rubin, M. J.; Albrecht, M. A.; Long, Q. G.; Sandoval, M. C.; Miller, A. J.

10.1101/2021.02.17.431656 — plant biology — Posted on 2021-02-17

1674 TuMV infection alters miR168/AGO1 and miR403/AGO2 systems regulation in Arabidopsis

Manacorda, C. A.; Tasselli, S.; Marano, M. R.; Asurmendi, S.

10.1101/2021.02.17.431672 — plant biology — Posted on 2021-02-17

1675 High-throughput and dosage-controlled intracellular delivery of large cargos by an acoustic-electric micro-vortices platform

Aghaamoo, M.; Chen, Y.-H.; Li, X.; Garg, N.; Jiang, R.; Lee, A. P.

10.1101/2021.02.16.431546 — bioengineering — Posted on 2021-02-17

1676 Evidence for a force favouring GC over AT at short intronic sites in Drosophila simulans and D. melanogaster

Jackson, B. C.; Charlesworth, B.

10.1101/2021.02.16.431542 — genetics — Posted on 2021-02-17

1677 Defining the Yeast Resistome through in vitro Evolution and Whole Genome Sequencing

Ottilie, S.; Luth, M. R.; Hellemann, E.; Goldgof, G. M.; Vigil, E.; Kumar, P.; Cheung, A. L.; Song, M.; Godinez-Macias, K. P.; Carolino, K.; Yang, J.; Lopez, G.; Abraham, M.; Tarsio, M.; LeBlanc, E.; Whitesell, L.; Schenken, J.; Gunawan, F.; Patel, R.; Smith, J.; Love, M. S.; Williams, R. M.; McNamara, C. W.; Gerwick, W. H.; Ideker, T.; Suzuki, Y.; Wirth, D. F.; Lukens, A. K.; Kane, P. M.; Cowen, L. E.; Durrant, J. D.; Winzeler, E. A.

10.1101/2021.02.17.430112 — genetics — Posted on 2021-02-17

1678 A tissue-aware machine learning framework enhances the mechanistic understanding and genetic diagnosis of Mendelian and rare diseases

Simonovsky, E.; Sharon, M.; Ziv, M.; Mauer, O.; Hekselman, I.; Jubran, J.; Vinogradov, E.; Argov, C. M.; Basha, O.; Kerber, L.; Yogev, Y.; Segre, A.; Im, H. K.; GTEx Consortium, ; Birk, O.; Rokach, L.; Yeger-Lotem, E.

10.1101/2021.02.16.430825 — genetics — Posted on 2021-02-17

1679 Temporal differentiation of resource capture and biomass accumulation as a driver of yield increase in intercropping

Engbersen, N.; Brooker, R. W.; Stefan, L.; Studer, B.; Schoeb, C.

10.1101/2021.02.17.431571 — ecology — Posted on 2021-02-17

1680 Chromosome segregation fidelity is controlled by small changes in kinetochore phospho-occupancy

Kucharski, T.; Hards, R.; Godek, K.; Gerber, S. A.; Compton, D. A.

10.1101/2021.02.16.431549 — cell biology — Posted on 2021-02-17

1681 Multidimensional Single-Nuclei RNA-Seq Reconstruction of Adipose Tissue Reveals Adipocyte Plasticity Underlying Thermogenic Response

Biagi, C. A.; Cury, S. S.; Alves, C. P.; Rahbi, N.; Silva, W. A.; Farmer, S. R.; Carvalho, R. F.; Batista, M. L.

10.1101/2021.02.16.431320 — cell biology — Posted on 2021-02-17

1682 Host preferences of coexisting Perkinsea parasitoids during coastal dinoflagellate blooms

Rene, A.; Timoneda, N.; Sampedro, N.; Alacid, E.; Gallisai, R.; Gordi, J.; Fernandez-Valero, A. D.; Pernice, M. C.; Flo, E.; Garces, E.

10.1101/2021.02.17.431570 — molecular biology — Posted on 2021-02-17

1683 F-type Pyocins are Diverse Non-Contractile Phage Tail-Like Weapons for Killing Pseudomonas aeruginosa

Saha, S.; Ojobor, C.; MacKinnon, E.; North, O. I.; Bondy-Denomy, J.; Lam, J. S.; Ensminger, A.; Maxwell, K. L.; Davidson, A. R.

10.1101/2021.02.16.431561 — microbiology — Posted on 2021-02-17

1684 Similar neural and perceptual masking effects of low-power optogenetic stimulation in primate V1

Chen, S. C.-Y.; Benvenuti, G.; Chen, Y.; Kumar, S.; Ramakrishnan, C.; Deisseroth, K.; Geisler, W. S.; Seidemann, E.

10.1101/2021.02.16.431182 — neuroscience — Posted on 2021-02-17

1685 The spatial signal in area LIP is not an obligatory correlate of perceptual evidence during informed saccadic choices

Seideman, J. A.; Stanford, T. R.; Salinas, E.

10.1101/2021.02.16.431470 — neuroscience — Posted on 2021-02-17

1686 Dynamic Auditory Remapping Across the Sleep-Wake Cycle

Arzi, A.; Trentin, C.; Laudini, A.; Krugliak, A.; Nikolla, D.; Bekinschtein, T.

10.1101/2021.02.16.431383 — neuroscience — Posted on 2021-02-17

1687 Discovery of a molecular glue that enhances UPRmt to restore proteostasis via TRKA-GRB2-EVI1-CRLS1 axis

Qi, L.-F.-R.; Qian, C.; Liu, S.; Peng, C.; Zhang, M.; Yang, P.; Wu, P.; Li, P.; Xu, X.

10.1101/2021.02.17.431525 — pharmacology and toxicology — Posted on 2021-02-17

1688 Structural basis for the Pr-Pfr long-range signaling mechanism of a full-length bacterial phytochrome at the atomic level

Otero, L. H.; Foscaldi, S.; Antelo, G. T.; Sirigu, S.; Klinke, S.; Defelipe, L. A.; Sanchez-Lamas, M.; Battocchio, G.; Chavas, L. M. G.; Goldbaum, F. A.; Mroginski, M. A.; Rinaldi, J.; Bonomi, H. R.

10.1101/2021.02.16.430237 — biophysics — Posted on 2021-02-17

1689 Mapping densely distributed membrane receptors in blood platelets with expansion microscopy

Heil, H. S.; Aigner, M.; Maier, S.; Goeb, V.; Kusch, C.; Meub, M.; Nieswandt, B.; Stegner, D.; Heinze, K. G.

10.1101/2021.02.16.431449 — biophysics — Posted on 2021-02-17

1690 Polyelectrolyte chain at thermal equilibrium: A comparison between the density functional theory framework (DFT) and the molecular dynamic simulations (MD)

Edwards, M. J.

10.1101/2021.02.17.431088 — biophysics — Posted on 2021-02-17

1691 Robust clustering and interpretation ofscRNA-seq data using reference componentanalysis

Schmidt, F.; Ranjan, B.; Xiao Xuan Lin, Q.; Krishnan, V.; Joanito, I.; Honardoost, M. A.; Nawaz, Z.; Venkatesh, P. N.; Tan, J.; Rayan, N. A.; Ong, S. T.; Prabhakar, S.

10.1101/2021.02.16.431527 — bioinformatics — Posted on 2021-02-17

1692 Synthesizing VERDICT maps from standard diffusion mp-MRI data using GANs

Chiou, E.; Valindria, V.; Giganti, F.; Punwani, S.; Kokkinos, I.; Panagiotaki, E.

10.1101/2021.02.16.431521 — bioengineering — Posted on 2021-02-17

1693 Polymorphism of Genetic Ambigrams

Dudas, G.; Huber, G.; Wilkinson, M.; Yllanes, D.

10.1101/2021.02.16.431493 — genomics — Posted on 2021-02-17

1694 Gene loss during the transition to multicellularity

Jimenez-Marin, B.; Rakijas, J. B.; Tyagi, A.; Pandey, A.; Hanschen, E. R.; Anderson, J.; Heffel, M. G.; Platt, T. G.; Olson, B. J. S. C.

10.1101/2021.02.16.431445 — evolutionary biology — Posted on 2021-02-17

1695 A test statistic to quantify treelikeness in phylogenetics

Cherryh, C.; Minh, B. Q.; Lanfear, R.

10.1101/2021.02.16.431544 — evolutionary biology — Posted on 2021-02-17

1696 Spatial model of water quality in Southeast Asian urban lake based on HBI using macrozoobenthos diversity as a proxy

Wibowo, A. A.

10.1101/2021.02.16.431487 — ecology — Posted on 2021-02-17

1697 Simons Collaborative Marine Atlas Project (Simons CMAP): an open-source portal to share, visualize and analyze ocean data

Dehghani Ashkezari, M.; Hagen, N. R.; Denholtz, M.; Neang, A.; Burns, T. C.; Morales, R. L.; Lee, C.; Hill, C.; Armbrust, E. V.

10.1101/2021.02.16.431537 — ecology — Posted on 2021-02-17

1698 Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells

Soares, M. A. F.; Soares, D. S.; Teixeira, V.; Bressan, R. B.; Pollard, S. M.; Oliveira, R. A.; Castro, D. S.

10.1101/2021.02.17.431407 — developmental biology — Posted on 2021-02-17

1699 Regulation of ribosomal protein synthesis in mycobacteria: autogenous control of rpsO

Boni, I. V.; Aseev, L. V.; Koledinskaya, L. S.; Bychenko, O. S.

10.1101/2021.02.16.431553 — molecular biology — Posted on 2021-02-17

1700 Biomolecular recognition of the glycan neoantigen CA19-9 by distinct antibodies

Borenstein-Katz, A.; Warszawski, S.; Amon, R.; Tasnima, N.; Yu, H.; Chen, X.; Padler-Karavani, V.; Fleishman, S. J.; Diskin, R.

10.1101/2021.02.17.431565 — molecular biology — Posted on 2021-02-17

1701 Tax induces the recruitment of NF-kB to unintegrated HIV-1 DNA to rescue viral gene expression and replication

Irwan, I. D.; Cullen, B. R.

10.1101/2021.02.16.431555 — molecular biology — Posted on 2021-02-17

1702 Molecular effects of mannanase-hydrolyzed coprameal to intestinal immunity in the Pacific white shrimp (Litopenaeus vannamei )

Rungrassamee, W.; Arayamethakorn, S.; Karoonuthaisiri, N.; Chen, S.-C.; Chang, E.; Chan, S.; Yoshida, Y.; Maebuchi, M.; Ibuki, M.

10.1101/2021.02.16.431529 — molecular biology — Posted on 2021-02-17

1703 Psilocin acutely disrupts sleep and affects local but not global sleep homeostasis in laboratory mice

Thomas, C. W.; Blanco-Duque, C.; Breant, B.; Sharp, T.; Goodwin, G.; Bannerman, D.; Vyazovskiy, V. V.

10.1101/2021.02.16.431276 — neuroscience — Posted on 2021-02-17

1704 Comparative analysis of Alzheimer's disease knock-in model brain transcriptomes implies changes to energy metabolism as a causative pathogenic stress

Barthelson, K.; Newman, M.; Lardelli, M.

10.1101/2021.02.16.431539 — neuroscience — Posted on 2021-02-17

1705 Statistical determinants of visuomotor adaptation in a virtual reality three-dimensional environment

Ferrea, E.; Morel, P.; Franke, J.; Gail, A.

10.1101/2021.02.16.431440 — neuroscience — Posted on 2021-02-17

1706 CAN CARBON NANOFIBERS AFFECT ANUROFAUNA? STUDY INVOLVING NEOTROPICAL Physalaemus cuvieri (Fitzinger, 1826) TADPOLES

Guimaraes, A. T. B.; Estrela, F. N.; Rodrigues, A. S. d. L.; Nobrega, R. H.; Charlie-Silva, I.; Malafaia, G.

10.1101/2021.02.16.431548 — zoology — Posted on 2021-02-17

1707 Early Dynamics of Chronic Myeloid Leukemia on Nilotinib Predicts Deep Molecular Response

Okamoto, Y.; Hirano, M.; Morino, K.; Kajita, M. K.; Nakaoka, S.; Tsuda, M.; Sugimoto, K.-j.; Tamaki, S.; Hisatake, J.; Yokoyama, H.; Igarashi, T.; Shinagawa, A.; Sugawara, T.; Hara, S.; Fujikawa, K.; Shimizu, S.; Yujiri, T.; Wakita, H.; Nishiwaki, K.; Tojo, A.; Aihara, K.

10.1101/2021.02.17.431221 — systems biology — Posted on 2021-02-17

1708 Leptin regulates glucose homeostasis via the canonical WNT pathway.

Kamstra, K.; Rizwan, M.; Horsfield, J. A.; Pretz, D.; Shepherd, P. R.; Grattan, D. R.; Tups, A.

10.1101/2021.02.16.431518 — physiology — Posted on 2021-02-17

1709 Toxicity Profile of Parenteral Artesunate following Subacute Treatment in Rats and Dogs

Lang, J. S.; Xiong, Y.; Thun-Battersby, S.; Huang, Q.

10.1101/2021.02.16.431559 — pharmacology and toxicology — Posted on 2021-02-17

1710 Bisphenol S and bisphenol F are less disruptive to cardiac electrophysiology and potentially safer for use in medical products, as compared to bisphenol A

Prudencio, T.; Swift, L.; Guerrelli, D.; Cooper, B.; Reilly, M.; Ciccarrelli, N.; Sheng, J.; Jaimes, R.; Posnack, N. G.

10.1101/2021.02.16.431039 — pharmacology and toxicology — Posted on 2021-02-17

1711 Nuclear HMGB1 protects from non-alcoholic fatty liver diseases through negative regulation of liver X receptor

Personnaz, J.; Piccolo, E.; Dortignac, A.; Iacovoni, J. S.; Mariette, J.; Polizzi, A.; Batut, A.; Deleruyelle, S.; Paccoud, R.; Moreau, E.; Martins, F.; Clouaire, T.; Benhamed, F.; Montagner, A.; Wahli, W. A.; Schwabe, R. F.; Yart, A.; Castan-Laurell, I.; Postic, C.; Moro, C.; Legube, G.; Lee, C.-H.; Guillou, H.; Valet, P.; Dray, C.; Pradere, J.-P.

10.1101/2021.02.17.431446 — pathology — Posted on 2021-02-17

1712 Spatiotemporal heterogeneity of glioblastoma is dictated by microenvironmental interference

Ravi, V. M.; Will, P.; Kuekelhaus, J.; Sun, N.; Joseph, K.; Salie, H.; von Ehr, J.; Vollmer, L.; Benotmane, J. K.; Neidert, N.; Follo, M.; Scherer, F.; Goeldner, J.; Behringer, S. P.; Franco, P.; Hofmann, U. G.; Fung, C.; Beck, J.; Sankowski, R.; Prinz, M.; Killmer, S.; Bengsch, B.; Walch, A. K.; Delev, D.; Schnell, O.; Heiland, D. H.

10.1101/2021.02.16.431475 — cancer biology — Posted on 2021-02-17

1713 Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries

Bazzaro, M.; Linder, S.; Shetty, M.; Zhang, X.; Clemente, V.

10.1101/2021.02.17.431266 — cancer biology — Posted on 2021-02-17

1714 A non-canonical role for glutamate decarboxylase 1 in cancer cell amino acid homeostasis, independent of the GABA shunt.

Samborska, B.; Griss, T.; Ma, E. H.; Jones, N.; Williams, K. S.; Sergushichev, A.; Johnson, R. M.; Esaulova, E.; Loginicheva, E.; Flynn, B.; Blagih, J.; Artyomov, M. N.; Jones, R. G.; Vincent, E. E.

10.1101/2021.02.17.431489 — cancer biology — Posted on 2021-02-17

1715 Optical Estimation of Absolute Membrane Potential Using One- and Two-Photon Fluorescence Lifetime Imaging Microscopy

Lazzari-Dean, J.; Miller, E.

10.1101/2021.02.16.431491 — biophysics — Posted on 2021-02-17

1716 Phosphatidylinositol phosphate binding domains exhibit complex dissociation properties at the inner leaflet of plasma membrane sheets

Sponholtz, M.; Senning, E. N.

10.1101/2021.02.17.431012 — biophysics — Posted on 2021-02-17

1717 AirLift: A Fast and Comprehensive Technique for Remapping Alignments between Reference Genomes

Kim, J. S.; Firtina, C.; Cavlak, M. B.; Cali, D. S.; Hajinazar, N.; Alser, M.; Alkan, C.; Mutlu, O.

10.1101/2021.02.16.431517 — bioinformatics — Posted on 2021-02-17

1718 PhylEx: Accurate reconstruction of clonal structure via integrated analysis of bulk DNA-seq and single cell RNA-seq data

Jun, S.-H.; Toosi, H.; Mold, J.; Engblom, C.; Chen, X.; O'Flanagan, C.; Hagemann-Jensen, M.; Sandberg, R.; Aparicio, S.; Hartman, J.; Roth, A.; Lagergren, J.

10.1101/2021.02.16.431009 — bioinformatics — Posted on 2021-02-17

1719 RaptGen: A variational autoencoder with profile hidden Markov model for generative aptamer discovery

Iwano, N.; Adachi, T.; Aoki, K.; Nakamura, Y.; Hamada, M.

10.1101/2021.02.17.431338 — bioinformatics — Posted on 2021-02-17

1720 The combined influence of viscoelastic and adhesive cues on fibroblast spreading and focal adhesion formation

Hui, E.; Moretti, L.; Barker, T. H.; Caliari, S. R.

10.1101/2021.02.17.430924 — bioengineering — Posted on 2021-02-17

1721 Sec17/Sec18 can support membrane fusion without help from completion of SNARE zippering

Song, H.; Torng, T. L.; Orr, A.; Brunger, A. T.; Wickner, W. T.

10.1101/2021.02.16.431494 — biochemistry — Posted on 2021-02-17

1722 Ancient migrations - The first complete genome assembly, annotation and variants of the Zoroastrian-Parsi community of India

Pasha, N.; Krishnasamy, K.; Nagarajan, N.; Mutya, S.; Mam, B.; Sonnekhan, K.; Gopalakrishnan, C.; Jain, R.; Patell, V.-M.

10.1101/2021.02.17.431362 — genomics — Posted on 2021-02-17

1723 Social stratification without genetic differentiation at the site of Kulubnarti in Christian Period Nubia

Sirak, K. A.; Fernandes, D. M.; Lipson, M.; Mallick, S.; Mah, M.; Olalde, I.; Ringbauer, H.; Rohland, N.; Hadden, C. S.; Harney, E.; Adamski, N.; Bernardos, R.; Broomandkhoshbacht, N.; Callan, K.; Ferry, M.; Lawson, A. M.; Michel, M.; Oppenheimer, J.; Stewardson, K.; Zalzala, F.; Patterson, N.; Pinhasi, R.; Thompson, J. C.; Van Gerven, D. P.; Reich, D.

10.1101/2021.02.17.431423 — genomics — Posted on 2021-02-17

1724 Evolutionary jumps in bacterial GC content

Mahajan, S.; Agashe, D.

10.1101/2021.02.16.431469 — evolutionary biology — Posted on 2021-02-17

1725 The expression of deep-sea fish visual genes supports a conserved cone-to-rod vertebrate retinal development

Lupse, N.; Cortesi, F.; Freese, M.; Marohn, L.; Pohlman, J.-D.; Wysujack, K.; Hanel, R.; Musilova, Z.

10.1101/2020.05.25.114991 — evolutionary biology — Posted on 2021-02-17

1726 Role and patterns of butterflies and hawkmoths in plant-pollinator networks at different elevations and seasons in tropical rainforests of Mount Cameroon

Mertens, J. E. J.; Brisson, L.; Janecek, S.; Klomberg, Y.; Maicher, V.; Safian, S.; Delabye, S.; Potocky, P.; Kobe, I. N.; Pyrcz, T.; Tropek, R.

10.1101/2021.02.16.431477 — ecology — Posted on 2021-02-17

1727 Shades of grey: Coat-colour dependent effect of urbanization on the bacterial microbiome of a wild mammal

Stothart, M. R.; Newman, A. E.

10.1101/2021.02.16.431540 — ecology — Posted on 2021-02-17

1728 Integrating plant stoichiometry and feeding experiments: state-dependent forage choice and its implications on body mass

Balluffi-Fry, J.; Leroux, S.; Wiersma, Y. F.; Richmond, I.; Heckford, T.; Rizzuto, M.; Kennah, J.; Vander Wal, E.

10.1101/2021.02.16.431523 — ecology — Posted on 2021-02-17

1729 A visual tour of carbon export by sinking particles

Durkin, C. A.; Buesseler, K. O.; Cetinic, I.; Estapa, M. L.; Kelly, R. P.; Omand, M.

10.1101/2021.02.16.431317 — ecology — Posted on 2021-02-17

1730 The Anna Karenina model of beta cell maturation in development and their dedifferentiation in type 1 and type 2 diabetes

Nimkulrat, S. D.; Ni, Z.; Brown, J.; Kendziorski, C.; Blum, B.

10.1101/2021.02.16.431507 — developmental biology — Posted on 2021-02-17

1731 Cardiac Specific Overexpression of Transcription Factor EB (TFEB) in Normal Hearts Induces Pathologic Cardiac Hypertrophy and Lethal Cardiomyopathy

Kenny, H. C.; Weatherford, E. T.; Collins, G. V.; Allamargot, C.; Gesalla, T.; Zimmerman, K.; Goel, H.; McLendon, J. M.; Dai, D.-F.; Romac, T.; Streeter, J.; Abhinav, D.; Pereira, R. O.; Sharafuddin, J.; Song, L.-S.; Abel, E. D.

10.1101/2021.02.16.431474 — cell biology — Posted on 2021-02-17

1732 Ex-vivo anticoagulants affect the mechanical properties of human blood platelets with implications for in vitro functional mechanophenotyping.

Sachs, L.; Wesche, J.; Lenkeit, L.; Greinacher, A.; Bender, M.; Otto, O.; Palankar, R.

10.1101/2021.02.17.428074 — cell biology — Posted on 2021-02-17

1733 A parasite's paradise: Biotrophic species prevail oomycete community composition in tree canopies

Jauss, R.-T.; Walden, S.; Fiore-Donno, A. M.; Schaffer, S.; Wolf, R.; Feng, K.; Bonkowski, M.; Schlegel, M.

10.1101/2021.02.17.431613 — microbiology — Posted on 2021-02-17

1734 Viral and parasitic cell ratios per free-living microbe across ecosystems

Lopez-Garcia, P.; Gutierrez-Preciado, A.; Ciobanu, M.; Deschamps, P.; Jardillier, L.; Lopez-Perez, M.; Rodriguez-Valera, F.; Moreira, D.

10.1101/2021.02.17.431581 — microbiology — Posted on 2021-02-17

1735 Fossil data do not support a long Pre-Cretaceous history of flowering plants

Budd, G. E.; Mann, R. P.; Doyle, J. A.; Coiro, M. P.; Hilton, J.

10.1101/2021.02.16.431478 — paleontology — Posted on 2021-02-17

1736 Traces of transposable element in genome dark matter co-opted by flowering gene regulation networks.

Baud, A.; Wan, M.; Nouaud, D.; Francillonne, N.; Anxolabehere, D.; Quesneville, H.

10.1101/547877 — genomics — Posted on 2021-02-17

1737 Anatomy, transcription dynamics and evolution of wheat ribosomal RNA loci deciphered by a multi-omics approach

Tulpova, Z.; Kovarik, A.; Toegelova, H.; Navratilova, P.; Kapustova, V.; Hribova, E.; Vrana, J.; Macas, J.; Dolezel, J.; Simkova, H.

10.1101/2020.08.29.273623 — genomics — Posted on 2021-02-17

1738 A suite of rare microbes interacts with a dominant, heritable, fungal endophyte to influence plant trait expression

Harrison, J.; Beltran, L. P.; Buerkle, C. A.; Cook, D.; Gardner, D.; Parchman, T. L.; Poulson, S. R.; Forister, M. L.

10.1101/608729 — ecology — Posted on 2021-02-17

1739 Measurement of Klebsiella Intestinal Colonization Density to Assess Infection Risk

Sun, Y.; Patel, A.; SantaLucia, J.; Roberts, E.; Zhao, L.; Kaye, K. S.; Rao, K.; Bachman, M. A.

10.1101/2021.02.16.431551 — microbiology — Posted on 2021-02-17

1740 Molecular characterization of vancomycin-resistant Enterococcus faecium isolates collected from the Dallas, Texas area

Islam, M.; Abaragu, A.; Sistu, H.; Akins, R. L.; Palmer, K. L.

10.1101/2021.02.16.431552 — microbiology — Posted on 2021-02-17

1741 A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptation

Kang, L.; He, G.; Sharp, A. K.; Wang, X.; Brown, A. M.; Michalak, P.; Weger-Lucarelli, J.

10.1101/2021.02.13.431090 — microbiology — Posted on 2021-02-17

1742 A measles-vectored COVID-19 vaccine induces long-term immunity and protection from SARS-CoV-2 challenge in mice

Frantz, P. N.; Barinov, A.; Ruffie, C.; Combredet, C.; Najburg, V.; Teeravechyan, S.; Jongkaewwattana, A.; Prot, M.; Conquet, L.; Montagutelli, X.; Fernandes, P.; Strick-Marchand, H.; Di Santo, J.; Simon-Loriere, E.; Gerke, C.; Tangy, F.

10.1101/2021.02.17.431630 — immunology — Posted on 2021-02-17

1743 Higher-order visual areas broaden stimulus responsiveness in mouse primary visual cortex

oude Lohuis, M. N.; Cerván Cantón, A.; Pennartz, C. M. A.; Olcese, U.

10.1101/2021.02.16.431393 — neuroscience — Posted on 2021-02-17

1744 Crowdsourced Identification of Multi-Target Kinase Inhibitors for RET- and TAU- Based Disease: the Multi-Targeting Drug DREAM Challenge

10.1101/2021.02.15.430538 — pharmacology and toxicology — Posted on 2021-02-17

1745 HLA binding of self-peptides is biased towards proteins with specific molecular functions

Karnaukhov, V.; Paes, W.; Woodhouse, I. B.; Partridge, T.; Nicastri, A.; Brackenridge, S.; Scherbinin, D.; Chudakov, D. M.; Zvyagin, I.; Ternette, N.; Koohy, H.; Borrow, P.; Shugay, M.

10.1101/2021.02.16.431395 — bioinformatics — Posted on 2021-02-17

1746 Rapid sequence evolution driven by transposable elements at a virulence locus in a fungal wheat pathogen

Singh, N. K.; Badet, T.; Abraham, L. N.; Croll, D.

10.1101/2021.02.16.431386 — genomics — Posted on 2021-02-17

1747 Association of CXCR6 with COVID-19 severity: Delineating the host genetic factors in transcriptomic regulation

Dai, Y.; Wang, J.; Jeong, H.-H.; Chen, W.; Jia, P.; Zhao, Z.

10.1101/2021.02.17.431554 — genetics — Posted on 2021-02-17

1748 Living apart if you can - how genetically and developmentally controlled sex has shaped the evolution of liverworts

He, X.; Flores, J. R.; Sun, Y.; Bowman, J. L.

10.1101/2021.02.08.430207 — evolutionary biology — Posted on 2021-02-17

1749 Effectiveness of Joint Species Distribution Models in the Presence of Imperfect Detection

Wang, Y.; Stone, L.; Hogg, S. E.

10.1101/2021.02.16.431325 — ecology — Posted on 2021-02-17

1750 Col6a1+/CD201+ telocytes regulate intestinal morphogenesis and homeostasis

Melissari, M.-T.; Henriques, A.; Tzaferis, C.; Prados, A.; Sarris, M. E.; Chouvardas, P.; Grammenoudi, S.; Kollias, G.; Koliaraki, V.

10.1101/2021.02.16.431453 — cell biology — Posted on 2021-02-17

1751 Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization

Turner, H. L.; Andrabi, R.; Cottrell, C. A.; Richey, S. T.; Song, G.; Callaghan, S.; Anzanello, F.; Moyer, T. J.; Abraham, W.; Melo, M.; Silva, M.; Scaringi, N.; Rakasz, E. G.; Sattentau, Q. J.; Irvine, D. J.; Burton, D. R.; Ward, A. B.

10.1101/2021.02.16.431310 — immunology — Posted on 2021-02-17

1752 Neural entrainment facilitates duplets: Frequency-tagging differentiates musicians and non-musicians when they tap to the beat

Celma-Miralles, A.; Kleber, B.; Toro, J. M.; Vuust, P.

10.1101/2021.02.15.431304 — neuroscience — Posted on 2021-02-17

1753 Perception of invisible masked objects in early infancy

Nakashima, Y.; Kanazawa, S.; Yamaguchi, M. K.

10.1101/2021.02.15.431195 — neuroscience — Posted on 2021-02-17

1754 Corollary discharge prevents signal distortion and enhances sensing during locomotion

Skandalis, D. A.; Lunsford, E. T.; Liao, J.

10.1101/2021.02.15.431323 — neuroscience — Posted on 2021-02-17

1755 Trial-by-trial fluctuations in post-stimulus attention during memory encoding predict subsequent associative context memory performance.

Elshiekh, A.; Rajah, M. N.

10.1101/2021.02.16.431454 — neuroscience — Posted on 2021-02-17

1756 Neurovascular unit alterations in the growth restricted newborn are improved following ibuprofen treatment

Chand, K. K.; Miller, S. M.; Cowin, G. J.; Mohanty, L.; Pienaar, J.; Colditz, P. B.; Bjorkman, S. T.; Wixey, J. A.

10.1101/2021.02.15.431329 — neuroscience — Posted on 2021-02-17

1757 Constitutive G protein coupling profiles of understudied orphan GPCRs

Lu, S.; Jang, W.; Inoue, A.; Lambert, N. A.

10.1101/2021.02.16.431425 — pharmacology and toxicology — Posted on 2021-02-17

1758 Accessibility Over Transposable Elements Reveals Genetic Determinants of Stemness Properties in Normal and Leukemic Hematopoiesis

Nadorp, B.; Grillo, G.; Qamra, A.; Mitchell, A.; Arlidge, C.; Takayama, N.; Murison, A.; Tonekaboni, S. A. M.; Arruda, A.; Wang, J.; Minden, M.; Dick, J.; Lupien, M.

10.1101/2021.02.16.431334 — cancer biology — Posted on 2021-02-17

1759 Computational Fluid Dynamics Modeling of Cough Transport in an Aircraft Cabin

Davis, A. C.; Zee, M.; Clark, A. D.; Wu, T.; Jones, S. P.; Waite, L. L.; Cummins, J. J.; Olson, N. A.

10.1101/2021.02.15.431324 — biophysics — Posted on 2021-02-17

1760 Probe the effect of clustering on EphA2 receptor signaling efficiency by subcellular control of ligand-receptor mobility

Chen, Z.; Oh, D.; Biswas, K. H.; Zaidel-Bar, R.; Groves, J. T.

10.1101/2021.02.16.431455 — biophysics — Posted on 2021-02-17

1761 kmtricks: Efficient construction of Bloom filters for large sequencing data collections

Lemane, T.; Medvedev, P.; Chikhi, R.; Peterlongo, P.

10.1101/2021.02.16.429304 — bioinformatics — Posted on 2021-02-17

1762 scGAE: topology-preserving dimensionality reduction for single-cell RNA-seq data using graph autoencoder

Luo, Z.; Xu, C.; Zhang, Z.; Jin, W.

10.1101/2021.02.16.431357 — bioinformatics — Posted on 2021-02-17

1763 E484K mutation in SARS-CoV-2 RBD enhances binding affinity with hACE2 but reduces interactions with neutralizing antibodies and nanobodies: Binding free energy calculation studies

Wang, W. B.; Liang, Y.; Jin, Y. Q.; Zhang, J.; Su, J. G.; Li, Q. M.

10.1101/2021.02.17.431566 — bioinformatics — Posted on 2021-02-17

1764 A dynamic view of histone tails interaction with clustered abasic sites in a nucleosome core particle

Bignon, E.; Gillet, N.; Jiang, T.; Morell, C.; Dumont, E.

10.1101/2021.02.16.431417 — biochemistry — Posted on 2021-02-17

1765 A fast, scalable, MinHash-based k-mer tool to assess Sequence Read Archive next generation sequence submissions.

Katz, K. S.; Shutov, O.; Lapoint, R.; Kimelman, M.; O'Sullivan, C.; Brister, J. R.

10.1101/2021.02.16.431451 — genomics — Posted on 2021-02-17

1766 The winding roads to adulthood: a twin study

Rimfeld, K.; Malanchini, M.; Packer, A. E.; Gidziela, A.; Allegrini, A. G.; Ayorech, Z.; Smith-Woolley, E.; McMillan, A.; Ogden, R.; Dale, P. S.; Eley, T. C.; Plomin, R.

10.1101/2021.02.16.431456 — genetics — Posted on 2021-02-17

1767 The evolution of the cytochrome c6 family of photosynthetic electron transfer proteins

Slater, B. A.; Kosmützky, D.; Nisbet, R. E. R.; Howe, C. J.

10.1101/2021.02.16.431308 — evolutionary biology — Posted on 2021-02-17

1768 Frequent origins of traumatic insemination involve convergent shifts in sperm and genital morphology

Brand, J. N.; Viktorin, G.; Wiberg, R. A. W.; Beisel, C.; Harmon, L. J.; Schaerer, L.

10.1101/2021.02.16.431427 — evolutionary biology — Posted on 2021-02-17

1769 Sexual Conflict Over Survival In Trinidadian Guppies

Lin, Y.; Darolti, I.; Furman, B. L. S.; Almeida, P.; Sandkam, B. A.; Breden, F.; Wright, A. E.; Mank, J. E.

10.1101/2021.02.16.431319 — evolutionary biology — Posted on 2021-02-17

1770 Positive selection in multiple salivary gland proteins of Anophelinae reveals potential targets for vector control

Freitas, L.; Nery, M. F.

10.1101/2021.02.16.431392 — evolutionary biology — Posted on 2021-02-17

1771 Delta C2 Domain β1-2 loop contributes to robust Notch signalling

Martins, T.; Meng, Y.; Korona, B.; Suckling, R.; Johnson, S.; Handford, P.; Lea, S. M.; Bray, S. J.

10.1101/2021.02.16.431397 — developmental biology — Posted on 2021-02-17

1772 In-cell structures of a conserved supramolecular array at the mitochondria-cytoskeleton interface in mammalian sperm

Leung, M. R.; Zenezini Chiozzi, R.; Roelofs, M.; Hevler, J. F.; Ravi, R. T.; Maitan, P.; Henning, H.; Zhang, M.; Bromfield, E.; Howes, S.; Gadella, B.; Heck, A. J. R.; Zeev-Ben-Mordehai, T.

10.1101/2021.02.16.431372 — cell biology — Posted on 2021-02-17

1773 Reporter gene assay for membrane fusion of extracellular vesicles

Somiya, M.; Kuroda, S.

10.1101/2021.02.16.431359 — cell biology — Posted on 2021-02-17

1774 The role of Dectin-1 signaling in altering tumor immune microenvironment in the context of aging

Pandiyan, P.

10.1101/2021.02.15.431361 — immunology — Posted on 2021-02-17

1775 FIBRIN POLYMER ON THE SURFACE OF BIOMATERIAL IMPLANTS DRIVES THE FOREIGN BODY REACTION

Balabiyev, A.; Podolnikova, N. P.; Kilbourne, J. A.; Baluch, D. P.; Lowry, D.; Zare, A.; Ros, R.; Flick, M. J.; Ugarova, T. P.

10.1101/2021.02.16.431282 — immunology — Posted on 2021-02-17

1776 Human primed endothelial colony forming cells exert neuroprotective effects in the growth restricted newborn piglet

Chand, K. K.; Patel, J.; Bjorkman, S. T.; Sim, S. L.; Miller, S. M.; Teo, E.; Jones, L.; Sun, J.; Colditz, P. B.; Khosrotehrani, K.; Wixey, J. A.

10.1101/2021.02.15.431307 — neuroscience — Posted on 2021-02-17

1777 Artificial Neurovascular Network (ANVN) to Study the Accuracy Vs. Efficiency Trade-Off in an Energy Dependent Neural Network

Kumar, B. S.; Mayakkannan, N.; Manojna, S.; Chakravarthy, V. S.

10.1101/2021.02.16.431351 — neuroscience — Posted on 2021-02-17

1778 Ketamine disrupts gaze patterns during face viewing in the common marmoset

Schaeffer, D. J.; Selvanayagam, J.; Wong, R. K.; Johnston, K.; Everling, S.

10.1101/2021.02.16.431438 — neuroscience — Posted on 2021-02-17

1779 Simulating homeostatic, allostatic and goal-directed forms of interoceptive control using Active Inference

Tschantz, A.; Barca, L.; Maisto, D.; Buckley, C. L.; Seth, A.; Pezzulo, G.

10.1101/2021.02.16.431365 — neuroscience — Posted on 2021-02-17

1780 THE COMPLEX HODOLOGICAL ARCHITECTURE OF THE MACAQUE DORSAL INTRAPARIETAL AREAS AS EMERGING FROM NEURAL TRACERS AND DW-MRI TRACTOGRAPHY

Caminiti, R.; Girard, G.; Battaglia Mayer, A.; Borra, E.; Schito, A.; Innocenti, G. M.; Luppino, G.

10.1101/2021.02.16.431444 — neuroscience — Posted on 2021-02-17

1781 Audiovisual adaptation is expressed in spatial and decisional codes

Aller, M.; Mihalik, A.; Noppeney, U.

10.1101/2021.02.15.431309 — neuroscience — Posted on 2021-02-17

1782 The role of network connectivity on epileptiform activity

Giacopelli, G.; Tegolo, D.; Migliore, M.

10.1101/2021.02.16.431388 — neuroscience — Posted on 2021-02-17

1783 Plant trait heterosis is quantitatively associated with expression heterosis of plastid ribosomal proteins

Birdseye, D.; De Boer, L.; Shen, Z.; Bai, H.; Zhou, P.; Schmelz, E. A.; Springer, N. M.; Briggs, S.

10.1101/2021.02.16.431485 — plant biology — Posted on 2021-02-17

1784 AGL16 negatively modulates stress response to balance with growth

Xiang, C.; Zhao, P.-X.; Zhang, J.; Chen, S.-Y.; Wu, J.; Xia, J.-Q.; Sun, L.-Q.; Ma, S.

10.1101/2021.02.16.431464 — plant biology — Posted on 2021-02-17

1785 A systems-level analysis of dynamic total-body PET data reveals complex skeletal energy metabolism networks in vivo

Suchacki, K. J.; Alcaide-Corral, C. J.; Nimale, S.; Macaskill, M. G.; Stimson, R. H.; Farquharson, C.; Freeman, T. C.; Tavares, A. A. S.

10.1101/2021.02.16.431368 — physiology — Posted on 2021-02-17

1786 Single cell transcriptome mapping identifies a local innate B cell population driving local antibody production and chronic rejection after lung transplantation

Smirnova, N. F.; Riemondy, K. A.; Collins, S.; Patel, K. N.; Cool, C.; Koenigshoff, M.; Sharma, N. S.; Eickelberg, O.

10.1101/2021.02.16.431278 — physiology — Posted on 2021-02-17

1787 Anthracyclins increase free PUFAs and etherPEs with PUFAs as potential hallmarks of lipid peroxidation and ferroptosis

Balgoma, D.; Kullenberg, F.; Calitz, C.; Kopsida, M.; Heindryckx, F.; Lennernas, H.; Hedeland, M.

10.1101/2021.02.16.431377 — cancer biology — Posted on 2021-02-17

1788 DNA translocase repositions a nucleosome by the lane-switch mechanism

Nagae, F.; Brandani, G. B.; Takada, S.; Terakawa, T.

10.1101/2021.02.15.431322 — biophysics — Posted on 2021-02-17

1789 Deciphering the molecular mechanism of the cancer formation by chromosome structural dynamics

Chu, X.; Wang, J.

10.1101/2021.02.15.431330 — biophysics — Posted on 2021-02-17

1790 Cardiac fibroblast mechanoresponse guides anisotropic organization of hiPSC-derived cardiomyocytes in vitro

Mostert, D.; Klouda, L.; Turnhout, M.; Kurniawan, N. A.; Bouten, C.

10.1101/2021.02.16.431369 — biophysics — Posted on 2021-02-17

1791 Slow chromatin dynamics enhances promoter accessibility to transcriptional condensates

YAMAMOTO, T.; SAKAUE, T.; Schiessel, H.

10.1101/2021.02.16.431394 — biophysics — Posted on 2021-02-17

1792 CONSTAX2: Improved taxonomic classification of environmental DNA markers

Liber, J. A.; Bonito, G.; Benucci, G. M. N.

10.1101/2021.02.15.430803 — bioinformatics — Posted on 2021-02-17

1793 MultiMAP: Dimensionality Reduction and Integration of Multimodal Data

Jain, M. S.; Dominguez Conde, C.; Polanski, K.; Chen, X.; Park, J.; Botting, R.; Stephenson, E.; Haniffa, M.; Lamacraft, A.; Efremova, M.; Teichmann, S.

10.1101/2021.02.16.431421 — bioinformatics — Posted on 2021-02-17

1794 Input-Output Slope Curve Estimation in Neural Stimulation Based on Optimal Sampling Principles

Alavi, M.; Goetz, S. M.; Saif, M.

10.1101/2021.02.16.431436 — bioinformatics — Posted on 2021-02-17

1795 N-terminal extensions strengthen hydrophobic inter-subunit interactions between HU's C-terminal domains to frustrate heterodimer formation

Arora, K.; Thakur, B.; Mrigwani, A.; Guptasarma, P.

10.1101/2021.02.16.431378 — biochemistry — Posted on 2021-02-17

1796 Identification of differentially distributed gene expression and distinct sets of cancer-related genes identified by changes in expression mean and variability

Roberts, A. G. K.; Catchpoole, D. R.; Kennedy, P. J.

10.1101/2021.02.15.431343 — genomics — Posted on 2021-02-17

1797 Change of information by positive frequency-dependent selection in two very different models (laser-like and chirality of shell-coiling in the snail Partula suturalis)

Tiefenbrunner, W.

10.1101/2021.02.15.431340 — evolutionary biology — Posted on 2021-02-17

1798 Understanding distribution and occupancy of Himalayan Monal in Uttarkashi district, Uttarakhand

Sharief, A.; Singh, H.; Joshi, B. D.; Mukherjee, T.; Chandra, K.; Thakur, M.; Sharma, L. K.

10.1101/2021.02.16.431367 — ecology — Posted on 2021-02-17

1799 Disentangling the relative importance of spatio-temporal parameters and host selectivity in shaping AMF communities in temperate forests

Gruenfeld, L.; Mola, M.; Wulf, M.; Hempel, S.; Veresoglou, S. D.

10.1101/2021.02.16.431389 — ecology — Posted on 2021-02-17

1800 Osmolarity-regulated swelling initiates egg activation in Drosophila

York-Andersen, A. H.; Wood, B. W.; Wilby, E. L.; Berry, A. S.; Weil, T. T.

10.1101/2021.02.16.431163 — developmental biology — Posted on 2021-02-17

1801 Demands of visual processing hierarchy shape laminar compartmentalization of attention modulation of luminance contrast in area V4

Wang, X.; Nandy, A.; Jadi, M.

10.1101/2021.02.15.431312 — neuroscience — Posted on 2021-02-17

1802 Cerebellar tDCS alters the perception of optic flow

Nankoo, J.-F.; Madan, C. R.; Medina, O.; Makepeace, T.; Striemer, C. L.

10.1101/2021.02.15.431326 — neuroscience — Posted on 2021-02-17

1803 Transcriptome sequence reveals candidate genes involving in the post-harvest hardening of trifoliate yam Dioscorea dumetorum

Siadjeu, C.; Mayland-Quellhorst, E.; Laubinger, S.; Albach, D. C.

10.1101/2021.02.16.431375 — plant biology — Posted on 2021-02-17

1804 Distinct metabolic flux modes through the tricarboxylic acid cycle in mesophyll and guard cells revealed by GC-MS-based 13C-positional isotopomer analysis

Daubermann, A. G.; Lima, V. F.; Schwarzlander, M.; Erban, A.; Kopka, J.; Fernie, A. R.; dos Anjos, L.; Daloso, D. M.

10.1101/2021.02.16.431495 — plant biology — Posted on 2021-02-17

1805 PAMP-triggered Genetic Reprogramming Involves Widespread Alternative Transcription Initiation and an Immediate Transcription Factor Wave

Brodersen, P.; Thieffry, A.; Bornholdt, J.; Barghetti, A.; Sandelin, A.

10.1101/2021.02.16.431463 — plant biology — Posted on 2021-02-17

1806 LC-MS Based Draft Map of the Arabidopsis thaliana Nuclear Proteome and Protein Import in Pattern Triggered Immunity

Ayash, M.; Abukhalaf, M.; Thieme, D.; Proksch, C.; Heilmann, M.; Schattat, M.; Hoehenwarter, W.

10.1101/2021.02.16.431396 — plant biology — Posted on 2021-02-17

1807 Drought is a stronger driver of plant morphology and nutritional composition than warming in two common pasture species

Catunda, K. L. M.; Churchill, A. C.; Zhang, H.; Power, S. A.; Moore, B. D.

10.1101/2021.02.16.431509 — plant biology — Posted on 2021-02-17

1808 IRONMAN Tunes Responses to Iron Deficiency in Concert with Environmental pH

Schmidt, W.; Tsai, H.-H.; Gautam, C. K.

10.1101/2021.02.16.431461 — plant biology — Posted on 2021-02-17

1809 Sucrose synthase activity is not required for cellulose biosynthesis in Arabidopsis

Wang, W.; Viljamaa, S.; Hodek, O.; Moritz, T.; Niittyla, T.

10.1101/2021.02.16.431385 — plant biology — Posted on 2021-02-17

1810 An HB40 - JUNGBRUNNEN1 - GA 2-OXIDASE regulatory module for gibberellin homeostasis in Arabidopsis

Dong, S.; Tarkowska, D.; Sedaghatmehr, M.; Molochko, M.; Gupta, S.; Mueller-Roeber, B.; Balazadeh, S.

10.1101/2021.02.17.431590 — plant biology — Posted on 2021-02-17

1811 Reexamination of N-terminal domains of Syntaxin-1 in vesicle fusion from central murine synapses

Vardar, G.; Salazar-Lazaro, A.; Brockmann, M.; Weber-Boyvat, M.; Zobel, S.; Kumbol, V. W.-A.; Trimbuch, T.; Rosenmund, C.

10.1101/2021.02.15.431257 — neuroscience — Posted on 2021-02-17

1812 Inferring population histories for ancient genomes using genome-wide genealogies

Speidel, L.; Cassidy, L.; Davies, R. W.; Hellenthal, G.; Skoglund, P.; Myers, S.

10.1101/2021.02.17.431573 — genomics — Posted on 2021-02-17

1813 A unified genealogy of modern and ancient genomes

Wohns, A. W.; Wong, Y.; Jeffery, B.; Akbari, A.; Mallick, S.; Pinhasi, R.; Patterson, N.; Reich, D.; Kelleher, J.; McVean, G.

10.1101/2021.02.16.431497 — genomics — Posted on 2021-02-17

1814 Role of the ubiquitin ligase ITCH in clathrin-mediated endocytosis of the epidermal growth factor receptor

Ayoubi, R.; McPherson, P. S.; Angers, A.

10.1101/2021.02.15.431259 — cell biology — Posted on 2021-02-17

1815 Deep behavioral phenotyping of mouse autism models using open-field behavior

Klibaite, U.; Kislin, M.; Verpeut, J. L.; Sun, X.; Shaevitz, J. W.; Wang, S. S.- H.

10.1101/2021.02.16.431500 — neuroscience — Posted on 2021-02-17

1816 Cerebellum controls timing of periaqueductal grey encoding of fear memory and expression of fear conditioned behaviour

Lawrenson, C.; Paci, E.; Drake, R. A. R.; Lumb, B. M.; Apps, R.

10.1101/2021.02.17.431584 — neuroscience — Posted on 2021-02-17

1817 Molecular origin of somatostatin-positive neuron vulnerability

Tomoda, T.; Sumitomo, A.; Newton, D.; Sibille, E.

10.1101/2021.02.16.431515 — neuroscience — Posted on 2021-02-17

1818 Cholecystokinin 1 Receptor (Cck1R) Activates mTORC1 signaling and is Protective to Purkinje cells in SCA Mice

Wozniak, E. A. L.; Chen, Z.; Yang, P.; Tschumperlin, T.; Berken, M.; Ingram, M.; Henzler, C.; Orr, H. T.

10.1101/2021.02.16.431490 — neuroscience — Posted on 2021-02-17

1819 Laminar dynamics of beta bursts in human motor cortex

Bonaiuto, J. J.; Little, S.; Neymotin, S. A.; Jones, S. R.; Barnes, G. R.; Bestmann, S.

10.1101/2021.02.16.431412 — neuroscience — Posted on 2021-02-17

1820 Corticotropin-releasing factor distribution in the brain of the brown anole lizard

Kabelik, D.

10.1101/2021.02.16.431399 — neuroscience — Posted on 2021-02-17

1821 NECAB2 orchestrates an endosomal pathway of mitochondrial quality control at striatal synapses

Narayan Dey, P.; Bueno, D.; Schacht, T.; Wolf, C.; Wüllner, V.; Morpurgo, E.; Rojas-Charry, L.; Sessinghaus, L.; Leukel, P.; Sommer, C.; Radyushkin, K.; Schaefer, M.; Florin, L.; Tenzer, S.; Baumgart, J.; Stamm, P.; Daiber, A.; Horta, G.; Nardi, L.; Vasic, V.; Schmeisser, M. J.; Hellwig, A.; Oskamp, A.; Bauer, A.; Anand, R.; Reichert, A. S.; Ritz, S.; Silies, M.; Frauenknecht, K. B. M.; Methner, A.

10.1101/2021.02.15.431234 — neuroscience — Posted on 2021-02-17

1822 Restricted nucleation and piRNA-mediated establishment of H3K9me3-dependent heterochromatin during embryogenesis in Drosophila miranda

Wei, K. H. C.; Chan, C.; Bachtrog, D.

10.1101/2021.02.16.431328 — genomics — Posted on 2021-02-17

1823 Tdrd3 regulates the progression of meiosis II through translational control of Emi2 mRNA in mouse oocytes

Takei, N.; Sato, K.; Takada, Y.; Iyyappan, R.; Susor, A.; Yamamoto, T.; Kotani, T.

10.1101/2021.02.17.431574 — developmental biology — Posted on 2021-02-17

1824 Cardiac Specific Overexpression of Transcription Factor EB (TFEB) in Normal Hearts Induces Pathologic Cardiac Hypertrophy and Lethal Cardiomyopathy

10.1101/2021.02.16.431474 — cell biology — Posted on 2021-02-17

1825 Metagenomes from the Loxahatchee wildlife refuge in the Florida Everglades

Benskin, J. B.; Alvarez, D. A.; Cadavid, N. A.; Childs, C. A.; Cupelli, M. F.; De, L. A.; Diaz, A. M.; Eldridge, S. A.; Elhabashy, Y. B.; Fleming, A. E.; Fox, N. A.; Franco, M.; Gaspari, J. C.; Gerstin, I. M.; Gibson, K. A.; Huott, A. L.; Johnson, A. O.; Majhess, E. G.; Mantilla, G.; Perez, G. S.; Prieto, J. J.; Reutter, B. C.; Rivera, E. I.; Rootes, T. R.; Sellers, J.; Streibig, A. M.; Wilkinson, J. S.; Zayas-Bazan, S.; Bhadha, J. H.; Clum, A.; Daum, C.; Glavina del Rio, T.; Lail, K.; Roux, S.; Eloe-Fadrosh, E.

10.1101/2021.02.16.430518 — microbiology — Posted on 2021-02-17

1826 Three-dimensional interactions between integrated HPV genomes and cellular chromatin dysregulate host gene expression in early cervical carcinogenesis

Groves, I. J.; Drane, E. L.; Michalski, M.; Monahan, J. M.; Scarpini, C. G.; Smith, S. P.; Bussotti, G.; Varnai, C.; Schoenfelder, S.; Fraser, P.; Enright, A. J.; Coleman, N.

10.1101/2021.02.03.429496 — cancer biology — Posted on 2021-02-17

1827 A rank-normalized archaeal taxonomy based on genome phylogeny resolves widespread incomplete and uneven classifications

Rinke, C.; Chuvochina, M.; Mussig, A. J.; Chaumeil, P.-A.; Waite, D. W.; Whitman, W. B.; Parks, D. H.; Hugenholtz, P.

10.1101/2020.03.01.972265 — microbiology — Posted on 2021-02-17

1828 Syntactic representations in the human brain: beyond effort-based metrics

Reddy, A. J.; Wehbe, L.

10.1101/2020.06.16.155499 — neuroscience — Posted on 2021-02-17

1829 7-Dehydrocholesterol-derived oxysterols cause neurogenic defects in Smith-Lemli-Opitz syndrome

Tomita, H.; Hines, K. M.; Herron, J. M.; Li, A.; Baggett, D. W.; Xu, L.

10.1101/2021.01.30.428955 — neuroscience — Posted on 2021-02-17

1830 Complex Activity and Short-term Memories in Reciprocally Connected Cerebral Organoids

Osaki, T.; Ikeuchi, Y.

10.1101/2021.02.16.431387 — neuroscience — Posted on 2021-02-16

1831 Parallel processing of working memory and temporal information by distinct types of cortical projection neurons

Bae, J. W.; Jeong, H.; Bae, C.; Lee, H.; Paik, S.-B.; Jung, M. W.

10.1101/2021.02.16.431447 — neuroscience — Posted on 2021-02-16

1832 Extended Graphical Lasso for Multiple Interaction Networks for High Dimensional Computational Data

Xu, Y.; Jiang, H.; Jiang, W.

10.1101/2021.02.16.431400 — systems biology — Posted on 2021-02-16

1833 Exceptional origin activation revealed by comparative analysis in two laboratory yeast strains

Peng, J.; Joshi, I.; Alvino, G. M.; Kwan, E.; Feng, W.

10.1101/2021.02.16.431410 — genomics — Posted on 2021-02-16

1834 VAMPIRE: A model blood cell trait focused annotation tool for interpretation and prioritization of complex trait genome-wide association study results

Crowley, C. A.; Sun, Q.; Huang, L.; Bao, E. L.; Auer, P.; Lettre, G.; Reiner, A. P.; Sankaran, V. G.; Raffield, L. M.; Li, Y.

10.1101/2021.02.16.431409 — genetics — Posted on 2021-02-16

1835 Screening of the antimicrobial activity of marine sponge extracts from Martinique.

Piron, J.; Pastour, J.; Tysklind, N.; Smith-Ravin, J.; Priam, F.

10.1101/2021.02.16.431398 — microbiology — Posted on 2021-02-16

1836 The global redox-responsive transcriptional regulator Rex represses fermentative metabolism and is required for Listeria monocytogenes pathogenesis

Halsey, C. R.; Thomason, M. K.; Glover, R. C.; Reniere, M. L.

10.1101/2021.02.16.431404 — microbiology — Posted on 2021-02-16

1837 Complement Decay-Accelerating Factor is a modulator of influenza A virus lung immunopathology

Santos, N. B.; Vaz da Silva, Z. E.; Gomes, C.; Reis, C. A.; Amorim, M. J.

10.1101/2021.02.16.431406 — microbiology — Posted on 2021-02-16

1838 Human cytomegalovirus blocks canonical TGFβ signaling during lytic infection to limit induction of type I interferons

Pham, A. H.; Mitchell, J.; Botto, S.; Pryke, K. M.; Defilippis, V. R.; Hancock, M.

10.1101/2021.02.16.431411 — microbiology — Posted on 2021-02-16

1839 A mixture of generative models strategy helps humans generalize across tasks

HERCE CASTANON, S.; Cardoso-Leite, P.; Green, C. S.; Altarelli, I.; Schrater, P.; Bavelier, D.

10.1101/2021.02.16.431506 — neuroscience — Posted on 2021-02-16

1840 Shared long-term and short-term memory representational formats in occipital and parietal cortex

Vo, V. A.; Sutterer, D. W.; Foster, J. J.; Sprague, T. C.; Awh, E.; Serences, J. T.

10.1101/2021.02.16.431528 — neuroscience — Posted on 2021-02-16

1841 Size matters: an analytical study on the role of tissue size in spatiotemporal distribution of morphogens unveils a transition between different reaction-diffusion regimes

Ceccarelli, A.; Borges, A.; Chara, O.

10.1101/2021.02.16.431401 — systems biology — Posted on 2021-02-16

1842 Supervised biomedical semantic similarity

Sousa, R. T.; Silva, S.; Pesquita, C.

10.1101/2021.02.16.431402 — bioinformatics — Posted on 2021-02-16

1843 High-resolution genetic mapping reveals cis-regulatory and copy number variation in loci associated with cytochrome P450-mediated detoxification in a generalist arthropod pest

Fotoukkiaii, S. M.; Wybouw, N.; Kurlovs, A. H.; Tsakireli, D.; Pergantis, S. A.; Clark, R. M.; Vontas, J.; Van Leeuwen, T.

10.1101/2021.02.16.431408 — genetics — Posted on 2021-02-16

1844 Virus relatedness predicts susceptibility in novel host species

Imrie, R.; Roberts, K. E.; Longdon, B.

10.1101/2021.02.16.431403 — evolutionary biology — Posted on 2021-02-16

1845 Endothelial cells elicit a pro-inflammatory response to SARS-COV-2 without productive viral infection

Schimmel, L.; Chew, K. Y.; Stocks, C.; Yordanov, T.; Essebier, T.; Kulasinghe, A.; Monkman, J.; Miggiolaro, A. F. R. d. S.; De Noronha, L.; Lagendijk, A. K.; Schroder, K.; Labzin, L.; Gordon, E. J.; Short, K. R.

10.1101/2021.02.14.431177 — cell biology — Posted on 2021-02-16

1846 Interpretable multi-timescale models for predicting fMRI responses to continuous natural speech

Jain, S.; Vo, V. A.; Mahto, S.; LeBel, A.; Turek, J. S.; Huth, A. G.

10.1101/2020.10.02.324392 — neuroscience — Posted on 2021-02-16

1847 Low-cost, scalable, and automated fluid sampling for fluidics applications

Booeshaghi, A. S.; Kil, Y.; Min, K. H.; Gehring, J.; Pachter, L.

10.1101/2021.01.27.428538 — bioengineering — Posted on 2021-02-16

1848 Unravelling processes between phenotypic plasticity and population dynamics in migratory birds

Liu, J.; Lei, W.; Mo, X.; Hassell, C. J.; Zhang, Z.; Coulson, T.

10.1101/2021.02.15.429667 — ecology — Posted on 2021-02-16

1849 Dynamics of hunchback translation in real time and at single mRNA resolution in the Drosophila embryo

Vinter, D. J.; Hoppe, C.; Minchington, T. G.; Sutcliffe, C.; Ashe, H.

10.1101/2021.02.16.430474 — developmental biology — Posted on 2021-02-16

1850 Functional basis for calmodulation of the TRPV5 calcium channel

Roig, S. R.; Thijssen, N.; van Erp, M.; Fransen, J.; Hoenderop, J.; van der Wijst, J.

10.1101/2021.02.16.431366 — cell biology — Posted on 2021-02-16

1851 High and stable ATP levels prevent aberrant intracellular protein aggregation

Takaine, M.; Imamura, H.; Yoshida, S.

10.1101/801738 — cell biology — Posted on 2021-02-16

1852 Diversity of excitatory release sites

Karlocai, R. R.; Heredi, J.; Benedek, T.; Holderith, N.; Lorincz, A.; Nusser, Z.

10.1101/2021.02.15.431316 — neuroscience — Posted on 2021-02-16

1853 The neural G protein Gαo tagged with GFP at an internal loop is functional in C. elegans

Kumar, S.; Olson, A. C.; Koelle, M. R.

10.1101/2021.02.16.431479 — neuroscience — Posted on 2021-02-16

1854 Sequence structure organizes items in varied latent states of working memory neural network

Huang, Q.; Zhang, H.; Luo, H.

10.1101/2020.06.20.162438 — neuroscience — Posted on 2021-02-16

1855 A practical modification to a resting state fMRI protocol for improved characterization of cerebrovascular function

Stickland, R. C.; Zvolanek, K. M.; Moia, S. C.; Ayyagari, A.; Caballero-Gaudes, C.; Bright, M. G.

10.1101/2021.02.15.431289 — neuroscience — Posted on 2021-02-16

1856 N-Terminal finger stabilizes the reversible feline drug GC376 in SARS-CoV-2 Mpro

Arutyunova, E.; Khan, M. B.; Fischer, C.; Lu, J.; Lamer, T.; Vuong, W.; van Belkum, M. J.; McKay, R. T.; Tyrrell, D. L.; Vederas, J. C.; Young, H. S.; Lemieux, M. J.

10.1101/2021.02.16.431021 — biophysics — Posted on 2021-02-16

1857 The Host Interactome of Spike Expands the Tropism of SARS-CoV-2

Bamberger, T. C.; Pankow, S.; Martinez-Bartolome, S.; Diedrich, J.; Park, R.; Yates, J. R.

10.1101/2021.02.16.431318 — molecular biology — Posted on 2021-02-16

1858 Synchrony between daily rhythms of malaria parasites and hosts is driven by an essential amino acid

Prior, K. F.; Middleton, B.; Owolabi, A. T.; Westwood, M. L.; Holland, J.; O'Donnell, A. J.; Blackman, M. J.; Skene, D. J.; Reece, S. E.

10.1101/2020.08.24.264689 — microbiology — Posted on 2021-02-16

1859 Bacteria elicit a phage tolerance response subsequent to infection of their neighbors

Tzipilevich, E.; Fiyaksel, O.; Ben-Yehuda, S.

10.1101/2021.02.16.428622 — microbiology — Posted on 2021-02-16

1860 Single-Domain SARS-CoV-2 S1 and RBD Antibodies Isolated from Immunized Llama Effectively Bind Targets of the Wuhan, UK, and South African Strains in vitro

Yamane, D.; Lu, I.; Tiahjono, W.; Rubidoux, L.; Hussain, A.; Cancilla, J. C.; Duggan, E.; Shaner, N. C.; Nakanishi, N.; Wang, J.

10.1101/2021.02.15.431198 — immunology — Posted on 2021-02-16

1861 Hepatitis C Virus E1 Protein Enhances Macrophage iNOS Expression In Vitro

Munkhjargal, B.; Enkhtuvshin, B.; Ulziisaikhan, U.; Tuvdenjamts, B.; Unurbuyan, K.; Sandagdorj, D.; Enkhjargal, B.; Sandag, T.; Tsolmon, B.; Lkhagvasuren, E.

10.1101/2021.02.15.431273 — immunology — Posted on 2021-02-16

1862 Detection of a biolistic delivery of fluorescent markers and CRISPR/Cas9 to the pollen tube

Nagahara, S.; Higashiyama, T.; Mizuta, Y.

10.1101/2021.02.15.431139 — plant biology — Posted on 2021-02-16

1863 Sucrose transport and metabolism control carbon partitioning between stem and grain in rice

Mathan, J.; Singh, A.; Ranjan, A.

10.1101/2020.10.03.324889 — plant biology — Posted on 2021-02-16

1864 Automated Feature Extraction from Large Cardiac Electrophysiological Data Sets

Jurkiewicz, J.; Zlochiver, V.; Kroboth, S.; Hinow, P.

10.1101/2020.10.21.340968 — physiology — Posted on 2021-02-16

1865 Neurological mechanism of sensory deficits after developmental exposure to non-dioxin-like polychlorinated biphenyls (PCBs)

Brun, N. R.; Panlilio, J. M.; Zhang, K.; Zhao, Y.; Ivashkin, E.; Stegeman, J.; Goldstone, J.

10.1101/2021.02.14.430009 — pharmacology and toxicology — Posted on 2021-02-16

1866 MEMS enabled miniaturized light-sheet microscopy with all optical control

Bakas, S.; Uttamchandani, D.; Toshiyoshi, H.; Bauer, R.

10.1101/2021.02.13.431066 — biophysics — Posted on 2021-02-16

1867 Differential contributions of M1 and pre-M1 to ion selectivity in ASICs and ENaCs

Sheikh, Z. P.; Wulf, M.; Friis, S.; Althaus, M.; Lynagh, T.; Pless, S. A.

10.1101/2021.02.16.431267 — biophysics — Posted on 2021-02-16

1868 DeepLC can predict retention times for peptides that carry as-yet unseen modifications

Bouwmeester, R.; Gabriels, R.; Hulstaert, N.; Martens, L.; Degroeve, S.

10.1101/2020.03.28.013003 — bioinformatics — Posted on 2021-02-16

1869 Quality control and processing of nascent RNA profiling data

Smith, J. P.; Dutta, A. B.; Sathyan, K. M.; Guertin, M. J.; Sheffield, N. C.

10.1101/2020.02.27.956110 — bioinformatics — Posted on 2021-02-16

1870 Rapid active-reflection display on dorsal stripes of Atherinomorus lacunosus

Iwasaka, M.

10.1101/2021.02.15.431186 — bioengineering — Posted on 2021-02-16

1871 A new method for determining ribosomal DNA copy number shows differences between Saccharomyces cerevisiae populations

Sharma, D.; Hermann-Le Denmat, S.; Matzke, N. J.; Hannan, K.; Hannan, R. D.; O'Sullivan, J. M.; Ganley, A. R. D.

10.1101/2021.01.21.427686 — genomics — Posted on 2021-02-16

1872 A hybrid stochastic-deterministic approach to explore multiple infection and evolution in HIV

Kreger, J.; Komarova, N. L.; Wodarz, D.

10.1101/2020.08.30.274142 — evolutionary biology — Posted on 2021-02-16

1873 Validating a high-throughput tracking system: ATLAS as a regional-scale alternative to GPS

Beardsworth, C. E.; Gobbens, E.; van Maarseveen, F.; Denissen, B.; Dekinga, A.; Nathan, R.; Toledo, S.; Bijleveld, A. I.

10.1101/2021.02.09.430514 — ecology — Posted on 2021-02-16

1874 Host phylogeny and host ecology structure the mammalian gut microbiota at different taxonomic scales

Rojas, C. A.; Ramirez-Barahona, S.; Holekamp, K. E.; Theis, K. R.

10.1101/2020.09.23.299727 — ecology — Posted on 2021-02-16

1875 RSC primes the quiescent genome for hypertranscription upon cell cycle re-entry

Cucinotta, C. E.; Dell, R. H.; Braceros, K. C. A.; Tsukiyama, T.

10.1101/2021.01.28.428695 — molecular biology — Posted on 2021-02-16

1876 Monoclonal antibodies targeting the influenza virus N6 neuraminidase

Strohmeier, S.; Amanat, F.; Carreno, J. M.; Krammer, F.

10.1101/2021.02.15.431355 — microbiology — Posted on 2021-02-16

1877 Do size and shape matter? Exploring the interactions and the metabolome of the soil isolate Hylemonella gracilis

Tyc, O.; Kulkarni, P.; Ossowicki, A.; Tracanna, V.; Medema, M.; Baarlen, P. v.; van IJcken, W.; Verhoeven, K. J. F.; Garbeva, P.

10.1101/2021.02.11.430889 — microbiology — Posted on 2021-02-16

1878 Nanoscale resolution of microbial fiber degradation in action

Tatli, M.; Morais, S.; Tovar-Herrera, O. E.; Bomble, Y.; Bayer, E. A.; Medalia, O.; Mizrahi, I.

10.1101/2021.02.16.431430 — microbiology — Posted on 2021-02-16

1879 Pilot study: Trehalose-induced remodelling of the human microbiota affects Clostridioides difficile infection outcome in an in vitro colonic model

Buckley, A.; Moura, I.; Arai, N.; Spittal, W.; Clark, E.; Nishida, Y.; Harris, H.; Bentley, K.; DAVIS, G.; Wang, D.; Mitra, S.; Higashiyama, T.; Wilcox, M. H.

10.1101/2021.02.16.431513 — microbiology — Posted on 2021-02-16

1880 Characterization of heliorhodopsins detected via functional metagenomics in freshwater Actinobacteria, Chloroflexi and Archaea

Chazan, A.; Rozenberg, A.; Mannen, K.; Nagata, T.; Tahan, R.; Yaish, S.; Larom, S.; Inoue, K.; Beja, O.; Pushkarev, A.

10.1101/2021.02.16.431466 — microbiology — Posted on 2021-02-16

1881 Development of chemosynthetic microbial communities in organic falls deployed in the deep Southwest Atlantic Ocean

Amendola, A. M.; Peres, F. V.; Moreira, J. C. F.; Sumida, P. Y. G.; Paula, F. S.; Pellizari, V. H.

10.1101/2021.02.16.431415 — microbiology — Posted on 2021-02-16

1882 Dynamin is primed at endocytic sites for ultrafast endocytosis

Imoto, Y.; Raychaudhuri, S.; Fenske, P.; Sandoval, E.; Itoh, K.; Blumrich, E.-M.; Mamer, L.; Zarebidaki, F.; Sohl-Kielczynski, B.; Trimbuch, T.; Nayak, S.; Iwasa, J. H.; Jorgensen, E. M.; Cousin, M. A.; Rosenmund, C. A.; Watanabe, S.

10.1101/2021.02.15.431332 — neuroscience — Posted on 2021-02-16

1883 Dietary folic acid deficiency impacts hippocampal morphology and cortical acetylcholine metabolism in adult male and female mice

Bennett, C.; Green, J.; Ciancio, M.; Goral, J.; Pitstick, L.; Pytynia, M.; Meyer, A.; Kwatra, N.; Jadavji, N. M.

10.1101/2020.12.13.422535 — neuroscience — Posted on 2021-02-16

1884 Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenic lineages

Redmond, S. A.; Cebrian Silla, A.; Assis Nascimento, M.; Mansky, B.; Wu, D.; Obernier, K.; Romero Rodriguez, R.; Lim, D. A.; Alvarez-Buylla, A.

10.1101/2021.02.10.430525 — neuroscience — Posted on 2021-02-16

1885 Optical activation of TrkB neurotrophin receptor in mouse ventral hippocampus promotes plasticity and facilitates fear extinction

Umemori, J.; Didio, G.; Winkel, F.; Pou, M. L.; Harkki, J.; Lo Russo, G.; Verie, M.; Antila, H.; Buj, C.; Taira, T.; Sari, L.; Guirado, R.; Castren, E.

10.1101/2021.02.14.431126 — neuroscience — Posted on 2021-02-16

1886 Nicotine-mediated recruitment of GABAergic neurons to a dopaminergic phenotype attenuates motor deficits in alpha-synuclein Parkinson's model.

Lai, I.-C.; Romoli, B.; Keisler, M.; Manfredsson, F.; Powell, S. B.; Dulcis, D.

10.1101/2021.02.15.431290 — neuroscience — Posted on 2021-02-16

1887 A compressed representation of spatial distance in the rodent hippocampus

Sheehan, D. J.; Charczynski, S.; Fordyce, B. A.; Hasselmo, M. E.; Howard, M. W.

10.1101/2021.02.15.431306 — neuroscience — Posted on 2021-02-16

1888 Antibiotic tolerance is associated with a broad and complex transcriptional response in E. coli

Deter, H. S.; Hossain, T.; Butzin, N. C.

10.1101/2020.08.27.270272 — systems biology — Posted on 2021-02-16

1889 Affordable Caenorhabditis elegans tracking system for classroom use

Leonard, N.; Vidal-Gadea, A. G.

10.1101/2020.12.28.424585 — scientific communication and education — Posted on 2021-02-16

1890 Gender and geographical disparity in editorial boards of journals in psychology and neuroscience

Palser, E. R.; Lazerwitz, M.; Fotopoulou, K.

10.1101/2021.02.15.431321 — scientific communication and education — Posted on 2021-02-16

1891 Pharmacologic Therapy for Engraftment Arrhythmia Induced by Transplantation of Human Cardiomyocytes

Nakamura, K.; Neidig, L. E.; Yang, X.; Weber, G. J.; El-nachef, D.; Tsuchida, H.; Dupras, S.; Kalucki, F. A.; Jayabalu, A.; Futakuchi-Tsuchida, A.; Nakamura, D. S.; Marchiano, S.; Bertero, A.; Robinson, M. R.; Cain, K.; Whittington, D.; Reinecke, H.; Pabon, L.; Knollmann, B. C.; Kattman, S.; Thies, R. S.; MacLellan, W. R.; Murry, C. E.

10.1101/2021.02.15.431108 — pharmacology and toxicology — Posted on 2021-02-16

1892 The ratio of exhausted to resident infiltrating lymphocytes is prognostic for colorectal cancer patient outcome

Foroutan, M.; Molania, R.; Pfefferle, A.; Behrenbruch, C.; Kallies, A.; Speed, T. P.; Cursons, J.; Huntington, N. D.

10.1101/2020.12.19.423379 — cancer biology — Posted on 2021-02-16

1893 Structural implications of agonist efficiency estimated from concentration-response curves

Indurthi, D.; Auerbach, A.

10.1101/2020.10.13.337410 — biophysics — Posted on 2021-02-16

1894 Correlation between structure and function in phosphatidylinositol lipid-dependent Kir2.2 gating

MacKinnon, R.; Zhang, Y.; Tao, X.

10.1101/2021.02.15.431350 — biophysics — Posted on 2021-02-16

1895 The Kinetic Landscape of Nucleosome Assembly: A Coarse-Grained Molecular Dynamics Study

Brandani, G. B.; Tan, C.; Takada, S.

10.1101/2021.02.14.431121 — biophysics — Posted on 2021-02-16

1896 Decoupling alignment strategy from feature quantification using a standard alignment incidence data structure

Choi, K.; Vincent, M. J.; Churchill, G. A.

10.1101/2021.02.16.431379 — bioinformatics — Posted on 2021-02-16

1897 Identification of common key genes and pathways between Covid-19 and lung cancer by using protein-protein interaction network analysis

Nana, K. S.; Karuppanan, K.; Kumar, S.

10.1101/2021.02.16.431364 — bioinformatics — Posted on 2021-02-16

1898 Enzyme engineering and in vivo testing of a formate-reduction pathway

Wang, J.; Anderson, K.; Yang, E.; He, L.; Lidstrom, M. E.

10.1101/2021.02.15.431286 — bioengineering — Posted on 2021-02-16

1899 501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to Bamlanivimab in vitro

Liu, H.; Wei, P.; Zhang, Q.; Chen, Z.; Aviszus, K.; Downing, W.; Peterson, S.; Reynoso, L.; Downey, G.; Frankel, S.; Kappler, J.; Marrack, P.; Zhang, G.

10.1101/2021.02.16.431305 — biochemistry — Posted on 2021-02-16

1900 Evaluation of Polygenic Prediction Methodology within a Reference-Standardized Framework

Pain, O.; Glanville, K. P.; Hagenaars, S. P.; Selzam, S. P.; Fürtjes, A. E.; Gaspar, H. A.; Coleman, J. R.; Rimfeld, K.; Breen, G.; Plomin, R.; Folkersen, L.; Lewis, C. M.

10.1101/2020.07.28.224782 — genomics — Posted on 2021-02-16

1901 CRISPR interference identifies vulnerable cellular pathways with bactericidal phenotypes in Mycobacterium tuberculosis

McNeil, M.; Keighley, L. M.; Cook, J. R.; Cheung, C.-Y.; Cook, G.

10.1101/2021.02.04.429736 — genomics — Posted on 2021-02-16

1902 Global detection of DNA repair outcomes induced by CRISPR-Cas9

Liu, M.; Zhang, W.; Xin, C.; Yin, J.; Shang, Y.; Ai, C.; Li, J.; Meng, F.-l.; Hu, J.

10.1101/2021.02.15.431335 — genomics — Posted on 2021-02-16

1903 Different evolutionary trends form the twilight zone of the bacterial pan-genome

Horesh, G.; Taylor-Brown, A.; McGimpsey, S.; Lassalle, F.; Corander, J.; Heinz, E.; Thomson, N. R.

10.1101/2021.02.15.431222 — genomics — Posted on 2021-02-16

1904 Whole plastid genome-based phylogenomics supports an inner placement of the O. insectifera group rather than a basal position in the rapidly diversifying Ophrys genus (Orchidaceae)

Bertrand, J. A. M.; Gibert, A.; Llauro, C.; Panaud, O.

10.1101/2020.12.16.423003 — evolutionary biology — Posted on 2021-02-16

1905 Range expansion shifts clonal interference patterns in evolving populations

Krishnan, N.; Fusco, D.; Scott, J. G.

10.1101/794867 — evolutionary biology — Posted on 2021-02-16

1906 Bro1 stimulates Vps4 activity to promote Intralumenal Vesicle Formation during Multivesicular Body biogenesis

Tseng, C.-c.; Dean, S.; Davies, B. A.; Azmi, I. F.; Pashkova, N.; Payne, J. A.; Staffenhagen, J.; West, M.; Piper, R. C.; Odorizzi, G.; Katzmann, D.

10.1101/2020.07.27.223255 — cell biology — Posted on 2021-02-16

1907 Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells

Le Vasseur, M.; Friedman, J. R.; Jost, M.; Xu, J.; Yamada, J.; Kampmann, M.; Horlbeck, M. A.; Weissman, J. S.; Nunnari, J.

10.1101/2021.02.16.431450 — cell biology — Posted on 2021-02-16

1908 Melanoma cells adopt features of both mesenchymal and amoeboid migration within confining channels

Gabbireddy, S. R.; Chung, A. J.; Logue, J. S.

10.1101/2021.02.12.431031 — cell biology — Posted on 2021-02-16

1909 Live attenuated SARS-CoV-2 vaccine candidate: Protective immunity without serious lung lesions in Syrian hamsters

Okamura, S.; Kashiwabara, A.; Suzuki, H.; Ueno, S.; Miyazato, P.; Takekawa, S.; Kamitani, W.; Yamanishi, K.; Ebina, H.

10.1101/2021.02.15.430863 — microbiology — Posted on 2021-02-16

1910 A Catalog of the Diversity and Ubiquity of Metabolic Organelles in Bacteria

Sutter, M.; Melnicki, M. R.; Schulz, F.; Woyke, T.; Kerfeld, C. A.

10.1101/2021.01.25.427685 — microbiology — Posted on 2021-02-16

1911 Organic electron donors and terminal electron acceptors structure anaerobic microbial communities and interactions in a permanently stratified sulfidic lake

Rojas, C. A.; De Santiago-Torio, A.; Park, S.; Bosak, T.; Klepac-Ceraj, V.

10.1101/2021.02.16.431432 — microbiology — Posted on 2021-02-16

1912 Seasonal Dynamics in the Number and Composition of Coliform Bacteria in Drinking Water Reservoirs

Reitter, C.; Petzoldt, H.; Korth, A.; Schwab, F.; Stange, C.; Hambsch, B.; Tiehm, A.; Lagkouvardos, I.; Gescher, J.; Huegler, M.

10.1101/2021.02.16.428560 — microbiology — Posted on 2021-02-16

1913 Genomes of gut bacteria from Nasonia wasps shed light on phylosymbiosis and microbe-assisted hybrid breakdown

Cross, K. L.; Leigh, B. A.; Hatmaker, E. A.; Mikaelyan, A.; Miller, A. K.; Bordenstein, S. R.

10.1101/2021.02.13.431100 — microbiology — Posted on 2021-02-16

1914 Metabolic constraints on nitrogen fixation by rhizobia in legume nodules

Schulte, C. C. M.; Borah, K.; Wheatley, R.; Terpolilli, J.; Saalbach, G.; Crang, N.; de Groot, D. H.; Ratcliffe, R. G.; Kruger, N. J.; Papachristodoulou, A.; Poole, P. S.

10.1101/2021.02.16.431433 — microbiology — Posted on 2021-02-16

1915 Favourable antibody responses to human coronaviruses in children and adolescents with autoimmune rheumatic diseases

Deakin, C.; Cornish, G.; Ng, K.; Faulkner, N.; Bolland, W.; Panova, V.; Hope, J.; Rosa, A.; Harvey, R.; Hussain, S.; Earl, C.; Jebson, B.; Wilkinson, M.; Marshall, L.; O'Brien, K.; Rosser, L.; Radziszewska, A.; Peckham, H.; Heaney, J.; Rickman, H.; Paraskevopoulou, S.; Houlihan, C.; Spyer, M.; Gamblin, S.; Mccauley, J.; Nastouli, E.; Cherepanov, P.; Ciurtin, C.; Wedderburn, L.; Kassiotis, G.

10.1101/2021.02.15.431291 — immunology — Posted on 2021-02-16

1916 Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV

Alrubayyi, A.; Gea-Mallorqui, E.; Touizer, E.; Hameiri-Bowen, D.; Kopycinski, J.; Charlton, B.; Fisher-Pearson, N.; Muir, L.; Rosa, A.; Roustan, C.; Earl, C.; Cherepanov, P.; Pellegrino, P.; Waters, L.; Burns, F.; Kinloch, S.; Dong, T.; Dorrell, L.; Rowland-Jones, S.; McCoy, L. E.; Peppa, D.

10.1101/2021.02.15.431215 — immunology — Posted on 2021-02-16

1917 A chicken IgY can efficiently inhibit the entry and replication of SARS-CoV-2 by targeting the ACE2 binding domain in vitro

Jingchen, W.; Yunfei, L.; Ying, R.; Xuanyu, Z.; Songqing, H.; Shuwen, W.; Qing, X.

10.1101/2021.02.16.430255 — immunology — Posted on 2021-02-16

1918 Multiple time scales of adaptation allow cones to encode the inputs created by visual exploration of natural scenes

Angueyra, J. M.; Baudin, J.; Schwartz, G. W.; Rieke, F.

10.1101/2021.02.13.431101 — neuroscience — Posted on 2021-02-16

1919 Speech auditory-motor adaptation lacks an explicit component: reduced adaptation in adults who stutter reflects limitations in implicit sensorimotor learning.

Kim, K. S.; Max, L.

10.1101/2020.09.06.284638 — neuroscience — Posted on 2021-02-16

1920 Generalization of motor learning in psychological space

Poh, E.; Al-Fawakhiri, N.; Tam, R.; Taylor, J. A.; McDougle, S. D.

10.1101/2021.02.09.430542 — neuroscience — Posted on 2021-02-16

1921 Analyses of infant vocal communication in mouse models of autism spectrum disorder using a novel unsupervised machine learning approach

Mai, L.; Kimura, R.; Hori, K.; Inada, H.; Kanno, K.; Matsuda, T.; Tachibana, R. O.; Yoshizaki, K.; Tucci, V.; Komaki, F.; Hoshino, M.; Osumi, N.

10.1101/738781 — neuroscience — Posted on 2021-02-16

1922 Passive visual stimulation induces fatigue or improvement depending on cognitive load

Ioannucci, S.; Borragan, G.; Zenon, A.

10.1101/2020.11.19.390096 — neuroscience — Posted on 2021-02-16

1923 Simulating the emergence of the Visual Word Form Area: Recycling a convolutional neural network for reading

Hannagan, T.; Agrawal, A.; Cohen, L.; Dehaene, S.

10.1101/2021.02.15.431235 — neuroscience — Posted on 2021-02-16

1924 IRGM/Irgm1 Aggravates Progression of Atherosclerosis by Inducing Macrophage Apoptosis through the MAPK Signaling Pathway

Fang, S.; Sun, S.; Cai, H.; Hao, X.; Zou, X.; Wan, X.; Tian, J.; Li, Z.; Wang, S.; He, Z.; Huang, W.; Liang, C.; Zhang, Z.; Yang, L.; Tian, J.; Yu, B.; Sun, B.

10.1101/2021.01.06.425662 — pathology — Posted on 2021-02-16

1925 A glycan gate controls opening of the SARS-CoV-2 spike protein

Sztain, T. E.; Ahn, S.-H.; Bogetti, A. T.; Casalino, L.; Goldsmith, J. A.; McCool, R. S.; Kearns, F. L.; McCammon, J. A.; McLellan, J. S.; Chong, L.; Amaro, R. E.

10.1101/2021.02.15.431212 — biophysics — Posted on 2021-02-16

1926 Transfer learning via multi-scale convolutional neural layers for human-virus protein-protein interaction prediction

Yang, X.; Yang, S.; Lian, X.; Wuchty, S.; Zhang, Z.

10.1101/2021.02.16.431420 — bioinformatics — Posted on 2021-02-16

1927 Oxidative stress induced by tBHP in human normal colon cells by label free Raman spectroscopy and imaging.The protective role of natural antioxidants in the form of β-carotene

Pluska, B. B.; Beton, K.

10.1101/2021.02.16.431391 — cancer biology — Posted on 2021-02-16

1928 How accurately can we assess zoonotic risk?

Wille, M.; Geoghegan, J. L.; Holmes, E. C.

10.1101/2020.08.17.254961 — microbiology — Posted on 2021-02-16

1929 Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1, a novel oncogene in AML

Nicosia, L.; Boffo, F. L.; Ceccacci, E.; Pallavicini, I.; Bedin, F.; Massignani, E.; Ravasio, R.; Minucci, S.; Bonaldi, T.

10.1101/2021.02.16.431315 — cancer biology — Posted on 2021-02-16

1930 Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells

Le Vasseur, M.; Friedman, J. R.; Jost, M.; Xu, J.; Yamada, J.; Kampmann, M.; Horlbeck, M. A.; Weissman, J. S.; Nunnari, J.

10.1101/2021.02.16.431450 — cell biology — Posted on 2021-02-16

1931 FRET-based screening in HEK293T identifies p38 MAPK and PKC inhibition as therapeutic targets for α-synuclein aggregation

Svanbergsson, A.; Ek, F.; Martinsson, I.; Rodo, J.; Liu, D.; Brandi, E.; Haikal, C.; Torres-Garcia, L.; Li, W.; Gouras, G.; Olsson, R.; Bjorklund, T.; Li, J.-Y.

10.1101/2021.02.16.431382 — molecular biology — Posted on 2021-02-16

1932 Dorsal CA1 Hippocampal Place Cells Form a Multi-Scale Representation of Megaspace

Harland, B.; Contreras, M.; Souder, M.; Fellous, J.-M.

10.1101/2021.02.15.431172 — neuroscience — Posted on 2021-02-16

1933 RCGAToolbox: A real-coded genetic algorithm software for parameter estimation of kinetic models

Maeda, K.; Boogerd, F. C.; Kurata, H.

10.1101/2021.02.15.431062 — systems biology — Posted on 2021-02-16

1934 Nets-within-nets for modeling emergent patterns in ontogeneticprocesses

Bardini, R.; Benso, A.; Politano, G.; Di Carlo, S.

10.1101/2021.02.15.430983 — systems biology — Posted on 2021-02-16

1935 Improving range shift predictions: enhancing the power of traits

Cannistra, A. F.; Buckley, L. B.

10.1101/2021.02.15.431292 — ecology — Posted on 2021-02-16

1936 Deletion of Small Ubiquitin-like Modifier-1 Attenuates Behavioral and Anatomical Deficits by Enhancing Functional Autophagic Activities in Huntington Disease

Ramirez Jarquin, U. N.; Sharma, M.; Shahani, N.; Subramaniam, S.

10.1101/2021.02.15.431277 — neuroscience — Posted on 2021-02-16

1937 Towards deciphering the Nt17 code: How the sequence and conformation of the first 17 amino acids in Huntingtin regulate the aggregation, cellular properties, and neurotoxicity of mutant Httex1

Vieweg, S.; Mahul-Mellier, A.-L.; Ruggeri, F. S.; Riguet, N.; DeGuire, S. M.; Chiki, A.; Cendrowska, U.; Dietler, G.; Lashuel, H. A.

10.1101/2021.02.15.431207 — neuroscience — Posted on 2021-02-16

1938 The hippocampus shows an own-age bias during unfamiliar face viewing

Koen, J. D.; Hauck, N.; Rugg, M. D.

10.1101/2021.02.15.431110 — neuroscience — Posted on 2021-02-16

1939 A new field instrument for leaf volatiles reveals an unexpected vertical profile of isoprenoid emission capacities in a tropical forest

Taylor, T. C.; Wisniewski, W. T.; Alves, E. G.; de Oliveira, R. C.; Saleska, S. R.

10.1101/2021.02.15.431157 — plant biology — Posted on 2021-02-16

1940 Variability in scRNA-Seq analysis is mitigated by regularized or supervised approaches

Durmaz, A.; Scott, J.

10.1101/2021.02.15.431268 — bioinformatics — Posted on 2021-02-16

1941 Quantitative susceptibility mapping of carotid arterial tissue ex vivo: assessing sensitivity to vessel microstructural composition

Stone, A. J.; Tornifoglio, B.; Johnston, R. D.; Shmueli, K.; Kerskens, C. M.; Lally, C.

10.1101/2021.02.15.431261 — bioengineering — Posted on 2021-02-16

1942 Magnetically stimulated cryogels to enhance osteogenic and chondrogenic differentiaton of stem cells

Odabas, S.; Tevlek, A.; Erenay, B.; Aydin, H. M.; Suloglu, A. K.; Yar Saglam, A. S.; Garipcan, B.

10.1101/2021.02.15.431106 — bioengineering — Posted on 2021-02-16

1943 Topoisomerase VI is a chirally-selective, preferential DNA decatenase

McKie, S. J.; Desai, P.; Seol, Y.; Maxwell, A.; Neuman, K. C.

10.1101/2021.02.15.431225 — biochemistry — Posted on 2021-02-16

1944 Towards end-to-end disease prediction from raw metagenomic data

Queyrel, M.; Prifti, E.; Templier, A.; Zucker, J.-D.

10.1101/2020.10.29.360297 — genomics — Posted on 2021-02-16

1945 The genome of the CTG(Ser1) yeast Scheffersomyces stipitis is plastic

Vega Estevez, S.; Armitage, A.; Bates, H. J.; Harrison, R. J.; Buscaino, A.

10.1101/2021.02.15.431239 — genomics — Posted on 2021-02-16

1946 Identification of salt tolerant genotypes in wheat using stress tolerance indices

Bakhshi, b.; Tabatabaei, S. M. T.; Naroui Rad, M. R.; Masoudi, B.

10.1101/2021.02.15.431202 — genetics — Posted on 2021-02-16

1947 On the phenology of protists: Recurrent patterns reveal seasonal variation of protistan (Rhizaria: Cercozoa, Endomyxa) communities in tree canopies

Walden, S.; Jauss, R.-T.; Feng, K.; Fiore-Donno, A. M.; Dumack, K.; Schaffer, S.; Wolf, R.; Schlegel, M.; Bonkowski, M.

10.1101/2021.02.15.431229 — ecology — Posted on 2021-02-16

1948 Anterior eye development in the brown anole, Anolis sagrei

Rasys, A. M.; Pau, S. H.; Irwin, K. E.; Luo, S.; Menke, D. B.; Lauderdale, J. D.

10.1101/2021.02.15.429783 — developmental biology — Posted on 2021-02-16

1949 A quantitative study of the Golgi retention of glycosyltransferases

Sun, X.; Chen, B.; Song, Z.; Lu, L.

10.1101/2021.02.15.431224 — cell biology — Posted on 2021-02-16

1950 The Role Of Senescent Cells Removal For Cell Culture Rejuvenation

Prokhorov, L. Y.

10.1101/2021.02.14.431016 — cell biology — Posted on 2021-02-16

1951 Microstructural determinants of lens stiffness in rat versus guinea pig lenses

Parreno, J.; Abera, K.; Aryal, S.; Forbes, K. E.; Fowler, V. M.

10.1101/2021.02.15.431302 — cell biology — Posted on 2021-02-16

1952 Optimal Reinforcement Learning with Asymmetric Updating in Volatile Environments: a Simulation Study

Rostami Kandroodi, M.; Vahabie, A.-h.; Ahmadi, S.; Nadjar Araabi, B.; Nili Ahmadabadi, M.

10.1101/2021.02.15.431283 — neuroscience — Posted on 2021-02-16

1953 The social cerebellum: A large-scale investigation of functional and structural specificity and connectivity

Metoki, A.; Wang, Y.; Olson, I. R.

10.1101/2021.02.15.431044 — neuroscience — Posted on 2021-02-16

1954 A hands-on tutorial on network and topological neuroscience

Centeno, E. G. Z.; Moreni, G.; Vriend, C.; Douw, L.; Santos, F. A. N.

10.1101/2021.02.15.431255 — neuroscience — Posted on 2021-02-16

1955 Poly (I:C)-induced maternal immune activation affects mouse visual discrimination performance and reversal learning in a sex-dependent manner.

Zhao, X.; Tran, H.; DeRose, H.; Roderick, R. C.; Kentner, A. C.

10.1101/2021.02.15.431275 — neuroscience — Posted on 2021-02-16

1956 Cerebral cortical communication overshadows computational energy-use, but these combine to predict synapse number

Levy, W. B.; Calvert, V. G.

10.1101/2021.02.15.431272 — neuroscience — Posted on 2021-02-16

1957 Exploring MEG brain fingerprints: evaluation, pitfalls and interpretations

Sareen, E.; Zahar, S.; Van De Ville, D.; Gupta, A.; Griffa, A.; Amico, E.

10.1101/2021.02.15.431253 — neuroscience — Posted on 2021-02-16

1958 A practical modification to a resting state fMRI protocol for improved characterization of cerebrovascular function

Stickland, R. C.; Zvolanek, K. M.; Moia, S. C.; Ayyagari, A.; Caballero-Gaudes, C.; Bright, M. G.

10.1101/2021.02.15.431289 — neuroscience — Posted on 2021-02-16

1959 Accuracy of the pneumatic method for estimating xylem vulnerability to embolism in temperate diffuse-porous tree species

Paligi, S. S.; Link, R. M.; Isaza, E.; Bittencourt, P.; Sarmento Cabral, J.; Jansen, S.; Oliveira, R. S.; Pereira, L.; Schuldt, B.

10.1101/2021.02.15.431295 — plant biology — Posted on 2021-02-16

1960 High-pressure sprayed siRNA triggers influence the efficiency but not the profile of transitive silencing

Uslu, V. V.; Dalakouras, A.; Steffens, V. A.; Krczal, G.; Wassenegger, M.

10.1101/2021.02.15.431219 — plant biology — Posted on 2021-02-16

1961 OBSTRUCTIVE APNEAS IN A MOUSE MODEL OF CONGENITAL CENTRAL HYPOVENTILATION SYNDROME

Madani, A.; Pitollat, G.; Sizun, E.; Cardoit, L.; Ringot, M.; BOURGEOIS, T.; Ramanantsoa, N.; Delclaux, C.; dauger, s.; d'Ortho, M.-P.; Thoby-Brisson, M.; GALLEGO, J.; Matrot, B.

10.1101/2021.02.15.431285 — physiology — Posted on 2021-02-16

1962 Can proteomics of snake venoms help drug discovery? A study on the venom of spectacled cobra (Naja naja) from the Western Ghats

Vanuopadath, M.; Raveendran, D.; Nair, B. G.; Sadasivan Nair, S.

10.1101/2021.02.15.431263 — pharmacology and toxicology — Posted on 2021-02-16

1963 Neurological mechanism of sensory deficits after developmental exposure to non-dioxin-like polychlorinated biphenyls (PCBs)

Brun, N. R.; Panlilio, J. M.; Zhang, K.; Zhao, Y.; Ivashkin, E.; Stegeman, J.; Goldstone, J.

10.1101/2021.02.14.430009 — pharmacology and toxicology — Posted on 2021-02-16

1964 The shifting of dominating roles between structural cells and immune cells are key regulators of human adipose tissues aging

Zhou, W.; Lin, J.; Hu, X.; Yao, X.; Hongwei, O.

10.1101/2021.02.15.431264 — pathology — Posted on 2021-02-16

1965 Dual MAPK and HDAC inhibition rewires the apoptotic rheostat to trigger colorectal cancer cell death

Jenkins, L. J.; Luk, I. Y.; Palmieri, M.; Fairlie, W. D.; Lee, E. F.; Schoffer, K. L.; Tan, T.; Ng, I.; Vukelic, N.; Tse, J. W.; Nightingale, R.; Alam, Z.; Iatropoulos, G.; Ernst, M.; Afshar-Sterle, S.; Desai, J.; Gibbs, P.; Sieber, O.; Dhillon, A.; Tebbutt, N. C.; Mariadason, J. M.

10.1101/2021.02.15.431252 — cancer biology — Posted on 2021-02-16

1966 massiveGenesetsTest: a web tool to run enrichment analysis.

Cerulo, L.; Pagnotta, S. M.

10.1101/2021.02.15.431228 — bioinformatics — Posted on 2021-02-16

1967 Comparative Analysis of common alignment tools for single cell RNA sequencing

Bruening, R. S.; Tombor, L.; Schulz, M. H.; Dimmeler, S.; John, D.

10.1101/2021.02.15.430948 — bioinformatics — Posted on 2021-02-16

1968 Cuban history of CRF19 recombinant subtype of HIV-1

ZHUKOVA, A.; Voznica, J.; Davila Felipe, M.; To, T.-H.; Perez, L.; Martinez, Y.; Pintos, Y.; Mendez, M.; Gascuel, O.; Kouri, V.

10.1101/2021.02.15.431210 — bioinformatics — Posted on 2021-02-16

1969 PandoraGAN: Generating antiviral peptides using Generative Adversarial Network

Surana, S.; Arora, P.; Singh, D.; Sahasrabuddhe, D.; Valadi, J.

10.1101/2021.02.15.431193 — bioinformatics — Posted on 2021-02-16

1970 Enzyme engineering and in vivo testing of a formate-reduction pathway

Wang, J.; Anderson, K.; Wang, J.; He, L.

10.1101/2021.02.15.431286 — bioengineering — Posted on 2021-02-16

1971 Copper signaling promotes proteostasis and animal development via allosteric activation of ubiquitin E2D conjugases

Opazo, C. M.; Lotan, A.; Xiao, Z.; Zhang, B.; Greenough, M. A.; Lim, C. M.; Trytell, H.; Ramirez, A.; Ukuwela, A. A.; Mawal, C. H.; McKenna, J.; Saunders, D. N.; Burke, R.; Gooley, P. R.; Bush, A. I.

10.1101/2021.02.15.431211 — biochemistry — Posted on 2021-02-16

1972 How to reach a higher selection plateau with optimal contribution selection and compensatory mating?

Tiret, M.; pegard, m.; sanchez-rodriguez, l.

10.1101/2021.02.15.431233 — evolutionary biology — Posted on 2021-02-16

1973 The Metabesity Factor HMG20A Potentiates Astrocyte Survival and Reactivity Preserving Neuronal Integrity

Lorenzo, P. I.; Fuente-Martin, E.; Mellado-Gil, J. M.; Guerrero Martinez, J. A.; Cobo-Vuilleumier, N.; Comaills, V.; Martin Vazquez, E.; Romero-Zerbo, S. Y.; Munoz Franco, J.; Perez-Caballo, J. A.; Rivero-Canalejo, S.; Campo-Caro, A.; Lachaud, C. C.; Aguilar Diosdado, M.; Garcia Fuentes, E.; Martin-Montalvo, A.; Alvarez Dolado, M.; Martin, F.; Rojo Martinez, G.; Pozo, D.; Bermudez-Silva, F. J.; Reyes, J. C.; Gauthier, B. R.

10.1101/2021.02.15.431213 — cell biology — Posted on 2021-02-16

1974 Synthetic dysmobility screen unveils an integrated STK40-YAP-MAPK system driving cell migration

Yu, L.-Y.; Tseng, T.-J.; Lin, H.-C.; Lu, T.-X.; Tsai, C.-J.; Lin, Y.-C.; Hsu, C.-L.; Tsai, F.-C.

10.1101/2021.02.15.431287 — cell biology — Posted on 2021-02-16

1975 Separate functional subnetworks of excitatory neurons show preference to periodic and random sound structures

Mehra, M.; Mukesh, A.; Bandyopadhyay, S.

10.1101/2021.02.13.431077 — neuroscience — Posted on 2021-02-16

1976 The relationship between dynamic functional network connectivity and spatial orientation in healthy young adults

Sendi, M. S. E.; Ellis, C. A.; Miller, R. L.; Salat, D. H.; Calhoun, V. D.

10.1101/2021.02.14.431143 — neuroscience — Posted on 2021-02-16

1977 Effect of aging-related network changes on unimanual sensorimotor learning - a simultaneous EEG-fMRI study

Chettouf, S.; Triebkorn, P.; Daffertshofer, A.; Ritter, P.

10.1101/2021.02.15.431203 — neuroscience — Posted on 2021-02-16

1978 Primary motor cortex activity traces distinct trajectories of population dynamics during spontaneous facial motor sequences in mice

Boffi, J. C.; Wiessalla, T.; Prevedel, R.

10.1101/2021.02.15.431209 — neuroscience — Posted on 2021-02-16

1979 Changes of mind after movement onset: a motor-state dependent decision-making process

Cos, I.; Pezzulo, G.; Cisek, P.

10.1101/2021.02.15.431196 — neuroscience — Posted on 2021-02-16

1980 The genetic code is not optimized for resource conservation

Xu, H.; Zhang, J. G.

10.1101/2021.02.08.430341 — evolutionary biology — Posted on 2021-02-16

1981 Typical somatomotor physiology of the hand is preserved in a patient with an amputated arm

van den Boom, M. A.; Miller, K. J.; Gregg, N. M.; Ojeda, G.; Lee, K. H.; Richner, T. J.; Ramsey, N. F.; Worrell, G. A.; Hermes, D.

10.1101/2021.02.12.430936 — neuroscience — Posted on 2021-02-16

1982 Stress diminishes outcome but enhances response representations during instrumental learning

Meier, J. K.; Staresina, B. P.; Schwabe, L.

10.1101/2021.02.12.430935 — neuroscience — Posted on 2021-02-16

1983 Paths to Oblivion: Common Neural Mechanisms of Anaesthesia and Disorders of Consciousness

10.1101/2021.02.14.431140 — neuroscience — Posted on 2021-02-16

1984 Fast Numerical Optimization for Genome Sequencing Data in Population Biobanks

Li, R.; Chang, C.; Tanigawa, Y.; Narasimhan, B.; Hastie, T.; Tibshirani, R. j.; Rivas, M. A.

10.1101/2021.02.14.431030 — bioinformatics — Posted on 2021-02-16

1985 Towards end-to-end disease prediction from raw metagenomic data

Queyrel, M.; Prifti, E.; Templier, A.; Zucker, J.-D.

10.1101/2020.10.29.360297 — genomics — Posted on 2021-02-16

1986 Effects of kinship correction on inflation of genetic interaction statistics in commonly used mouse populations

Tyler, A.; Tyler, A. L.; El Kassaby, B.; Kolishovski, G.; Emerson, J.; Wells, A. E.; Mahoney, J. M.; Carter, G. W.

10.1101/2021.02.14.431191 — genetics — Posted on 2021-02-16

1987 What are housekeeping genes?

Joshi, C. J.; Ke, W.; Drangowska-Way, A.; O'Rourke, E. J.; Lewis, N. E.

10.1101/2021.02.14.431149 — evolutionary biology — Posted on 2021-02-16

1988 Unravelling processes between phenotypic plasticity and population dynamics in migratory birds

Liu, J.; Lei, W.; Mo, X.; Hassell, C. J.; Zhang, Z.; Coulson, T.

10.1101/2021.02.15.429667 — ecology — Posted on 2021-02-16

1989 Chitinase 3-like-1 is a Therapeutic Target That Mediates the Effects of Aging in COVID-19

Kamle, S.; Ma, B.; He, C. H.; Akosman, B.; Zhou, Y.; Lee, C.-M.; El-Deiry, W. S.; Huntington, K.; Liang, O.; Machan, J. T.; Kang, M.-J.; Shin, H. J.; Mizoguchi, E.; Lee, C. G.; Elias, J. A.

10.1101/2021.01.05.425478 — immunology — Posted on 2021-02-16

1990 The essential role of Dnmt1 in gametogenesis in the large milkweed bug Oncopeltus fasciatus

Washington, J. T.; Cavender, K. R.; Amukamara, A. U.; McKinney, E. C.; Schmitz, R. J.; Moore, P. J.

10.1101/2020.07.23.218180 — evolutionary biology — Posted on 2021-02-16

1991 COVID-19 Disease Map, a computational knowledge repository of SARS-CoV-2 virus-host interaction mechanisms

10.1101/2020.10.26.356014 — systems biology — Posted on 2021-02-16

1992 freqpcr: estimation of population allele frequency using qPCR ΔΔCq measures from bulk samples

Sudo, M.; Osakabe, M.

10.1101/2021.01.19.427228 — bioinformatics — Posted on 2021-02-16

1993 Privacy preserving storage of sequenced genomic data

Hekel, R.; Budis, J.; Kucharik, M.; Radvanszky, J.; Pos, Z.; Szemes, T.

10.1101/2020.09.16.299594 — bioinformatics — Posted on 2021-02-16

1994 Sox2 controls neural stem cell self-renewal through a Fos-centered gene regulatory network

Pagin, M.; Pernebrink, M.; Giubbolini, S.; Barone, C.; Sambruni, G.; Zhu, Y.; Chiara, M.; Ottolenghi, S.; Pavesi, G.; Wei, C.-L.; Cantu, C.; Nicolis, S. K.

10.1101/2020.03.17.995621 — genetics — Posted on 2021-02-16

1995 Rapid behavioural response of urban birds to COVID-19 lockdown

Gordo, O.; Brotons, L.; Herrando, S.; Gargallo, G.

10.1101/2020.09.25.313148 — ecology — Posted on 2021-02-16

1996 SARS-CoV2 envelop proteins reshape the serological responses of COVID-19 patients

Martin, S.; Heslan, C.; Jegou, G.; Eriksson, L. A.; Le Gallo, M.; Thibault, V.; Chevet, E.; Godey, F.; Avril, T.

10.1101/2021.02.15.431237 — cell biology — Posted on 2021-02-16

1997 The ecological significance of extracellular vesicles in modulating host-virus interactions during algal blooms

Schatz, D.; Schleyer, G.; Saltvedt, M. R.; Sandaa, R.-A.; Feldmesser, E.; Vardi, A.

10.1101/2021.02.10.430559 — microbiology — Posted on 2021-02-16

1998 GABA administration limits viral replication and pneumonitis in a mouse model of COVID-19

Tian, J.; Middleton, B.; Kaufman, D. L.

10.1101/2021.02.09.430446 — immunology — Posted on 2021-02-16

1999 Development of a vaccine against the newly emerging COVID-19 virus based on the receptor binding domain displayed on virus-like particles

Zha, L.; Zhao, H.; Mohsen, M. O.; Hong, L.; Zhou, Y.; Li, Z.; Chen, H.; Liu, X.; Chang, X.; Zhang, J.; Li, D.; Wu, K.; Vogel, M.; Bachmann, M. F.; Wang, J.

10.1101/2020.05.06.079830 — immunology — Posted on 2021-02-16

2000 Database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging data

Rupprecht, P.; Carta, S.; Hoffmann, A.; Echizen, M.; Blot, A.; Kwan, A. C.; Dan, Y.; Hofer, S. B.; Kitamura, K.; Helmchen, F.; Friedrich, R. W.

10.1101/2020.08.31.272450 — neuroscience — Posted on 2021-02-16

2001 Sequence structure organizes items in varied latent states of working memory neural network

Huang, Q.; Zhang, H.; Luo, H.

10.1101/2020.06.20.162438 — neuroscience — Posted on 2021-02-16

2002 When less feels stronger: Earliest cortical responses differentially reflect stimulus intensity and neural excitability

Stephani, T.; Hodapp, A.; Jamshidi Idaji, M.; Villringer, A.; Nikulin, V. V.

10.1101/2020.11.27.401430 — neuroscience — Posted on 2021-02-16

2003 Unravelling the Physiological Correlates of Mental Workload Variations in Tracking and Collision Prediction Tasks: Implications for Air Traffic Controllers

John, A. R.; Singh, A. K.; Do, T.-T. N.; Eidels, A.; Nalivaiko, E.; Gavgani, A. M.; Brown, S.; Bennett, M.; Lal, S.; Simpson, A. M.; Gustin, S. M.; Double, K.; Walker, F. R.; Kleitman, S.; Morley, J.; Lin, C.-T.

10.1101/2021.02.02.428702 — neuroscience — Posted on 2021-02-16

2004 A behavioral paradigm for cortical control of a robotic arm by freely moving rats in a one-dimensional center-out reaching task

Zaidi, S. M. T.; Kocaturk, S.; Baykas, T.; Kocaturk, M.

10.1101/2021.01.24.427325 — neuroscience — Posted on 2021-02-16

2005 Enhanced habit formation in Tourette syndrome : dopamine release and striatal disinhibition modulate shortcut connections in a hierarchical model of cortico-basal ganglia loops

Scholl, C.; Baladron, J.; Vitay, J.; Hamker, F. H.

10.1101/2021.02.08.430235 — neuroscience — Posted on 2021-02-16

2006 Thalamocortical axons control the cytoarchitecture of neocortical layers by area-specific supply of secretory proteins

Sato, H.; Hatakeyama, J.; Iwasato, T.; Araki, K.; Yamamoto, N.; Shimamura, K.

10.1101/2021.02.14.431161 — neuroscience — Posted on 2021-02-16

2007 Individual variability of neural computations in the primate retina

Shah, N.; Brackbill, N.; Samarakoon, R.; Rhoades, C.; Kling, A.; Sher, A.; Litke, A.; Singer, Y.; Shlens, J.; Chichilnisky, E. J.

10.1101/2021.02.14.431169 — neuroscience — Posted on 2021-02-16

2008 Environmental enrichment mitigates stroke-induced change in sharp-wave associated ripple characteristics

Ip, Z.; Rabiller, G.; He, J.-W.; Chavan, S.; Nishijima, Y.; Akamatsu, Y.; Liu, J.; Yazdan-Shahmorad, A.

10.1101/2021.02.12.431002 — neuroscience — Posted on 2021-02-16

2009 Fabrication and electromechanical characterization of free-standing asymmetric membranes

Liu, P.; Zabala-Ferrera, O.; Beltramo, P. J.

10.1101/2020.10.08.331470 — biophysics — Posted on 2021-02-16

2010 The molecular pH-response mechanism of the plant light-stress sensor PsbS

Krishnan-Schmieden, M.; Konold, P.; Kennis, J.; Pandit, A.

10.1101/457614 — biophysics — Posted on 2021-02-16

2011 Human.miRFFL.DB- A curated resource for human miRNA coregulatory networks and associated regulatory-circuits

Khurana, P.; Varshney, R.; Sugadev, R.; Sharma, Y. K.

10.1101/2020.05.16.097865 — bioinformatics — Posted on 2021-02-16

2012 Sensitive and reproducible cell-free methylome quantification with synthetic spike-in controls

Wilson, S. L.; Shen, S. Y.; Harmon, L. M.; Burgener, J. M.; Bratman, S. V.; Triche, T. J.; De Carvalho, D. D.; Hoffman, M. M.

10.1101/2021.02.12.430289 — genomics — Posted on 2021-02-16

2013 Coupling spectral and resource-use complementarity in experimental grassland and forest communities

Schweiger, A. K.; Cavender-Bares, J.; Kothari, S.; Townsend, P. A.; Madritch, M. D.; Grossman, J. J.; Gholizadeh, H.; Wang, R.; Gamon, J. A.

10.1101/2020.04.24.060483 — ecology — Posted on 2021-02-16

2014 Id4 is required for normal ependymal cell development

Rocamonde, B.; Herranz-Perez, V.; Garcia-Verdugo, J.-M.; Huillard, E.

10.1101/2021.02.15.431205 — developmental biology — Posted on 2021-02-16

2015 Akkermansia muciniphila secretome promotes α-synuclein aggregation in enteroendocrine cells.

Amorim Neto, D. P.; Bosque, B. P.; de Godoy, J. V. P.; Rodrigues, P. V.; Meneses, D. D.; Tostes, K.; Tonoli, C. C. C.; Gonzalez-Billault, C.; Fonseca, M. d. C.

10.1101/2021.02.12.430931 — cell biology — Posted on 2021-02-16

2016 Differentially accessible Cdc4 phospho-degrons regulate Ctf19CCAN kinetochore subunit stability in mitosis

Westermann, S.; Böhm, M.; Killinger, K.; Dudziak, A.; Pant, P.; Jänen, K.; Hohoff, S.; Mechtler, K.; Örd, M.; Loog, M.; Sanchez-Garcia, E.

10.1101/2021.02.12.430993 — cell biology — Posted on 2021-02-16

2017 The cohesin regulator Stag1 promotes cell plasticity through heterochromatin regulation.

Pezic, D.; Weeks, S.; Varsally, W.; Dewari, P. S.; Branco, M.; HADJUR, S.

10.1101/2021.02.14.429938 — cell biology — Posted on 2021-02-16

2018 Dynamic association of IκBα to chromatin is regulated by acetylation and cleavage of histone H4

Espinosa, L.; Bertran, J.; Alvarez-Villanueva, D.; Floor, M.; Mulero, M. C.; Vert, A.; Guillen, Y.; Arce, S.; Batlle-Morera, L.; Villa-Freixa, J.; Ghosh, G.; Bigas, A.; Marruecos, L.

10.1101/2021.02.15.431217 — molecular biology — Posted on 2021-02-16

2019 Transcriptional and translational responsiveness of the Neisseria gonorrhoeae type IV secretion system to conditions of host infections

Callaghan, M. M.; Klimowicz, A. K.; Shockey, A. C.; Kane, J.; Pepperell, C.; Dillard, J. P.

10.1101/2021.02.12.431057 — microbiology — Posted on 2021-02-16

2020 Initial HCV infection of adult hepatocytes triggers a temporally structured transcriptional program containing diverse pro- and anti-viral elements

Tegtmeyer, B.; Vieyres, G.; Todt, D.; Lauber, C.; Ginkel, C.; Engelmann, M.; Herrmann, M.; Pfaller, C. K.; Vondran, F. W. R.; Broering, R.; Vafadarnejad, E.; Saliba, A.-E.; Puff, C.; Baumgärtner, W.; Miskey, C.; Ivics, Z.; Steinman, E.; Pietschmann, T.; Brown, R. J. P.

10.1101/2021.02.12.431054 — immunology — Posted on 2021-02-16

2021 Relation of inflammatory marker trajectories with frailty and aging in a 20-year longitudinal study

Samson, L. D.; Buisman, A.-M.; Ferreira, J. A.; Picavet, H. S. J.; Verschuren, W. M. M.; Boots, A. M. H.; Engelfriet, P.

10.1101/2021.02.10.430670 — immunology — Posted on 2021-02-16

2022 Cortical compensation for hearing loss, but not age, in neural tracking of the fundamental frequency of the voice

Van Canneyt, J.; Wouters, J.; Francart, T.

10.1101/2021.02.16.431374 — neuroscience — Posted on 2021-02-16

2023 Generalization of motor learning in psychological space

Poh, E.; Al-Fawakhiri, N.; Tam, R.; Taylor, J. A.; McDougle, S. D.

10.1101/2021.02.09.430542 — neuroscience — Posted on 2021-02-16

2024 A multi-phase multi-objective genome-scale model shows diverse redox balance strategies in yeasts

Henriques, D.; Minebois, R.; Mendonza, S.; Macias, L. G.; Perez-Torrado, R.; barrio, E.; Teusink, B.; Querol, A.; Balsa-Canto, E.

10.1101/2021.02.11.430755 — systems biology — Posted on 2021-02-16

2025 Potential of fungicides, botanicals and biocontrol agents to induce physio-biochemical tolerance on Curcuma longa impaired by Colletotrichum gloeosporioides

Musheer, N.; Ashraf, S.; Jamil, A.

10.1101/2021.02.11.430813 — pathology — Posted on 2021-02-16

2026 Molecular View of Biomimetic Peptide in Action with Membrane

Koneru, J.; Prakashchand, D. D.; Dube, N.; Ghosh, P.; Mondal, J.

10.1101/2021.02.12.430925 — biophysics — Posted on 2021-02-16

2027 Synaptotagmin-like protein 2a regulates lumen formation via Weibel-Palade body apical secretion of angiopoietin-2 during angiogenesis

Francis, C. R.; Claflin, S.; Kushner, E.

10.1101/2021.02.15.431296 — developmental biology — Posted on 2021-02-16

2028 The Relationship between Birth Timing, Circuit Wiring, and Physiological ResponseProperties of Cerebellar Granule Cells

Shuster, A.; Wagner, M.; Pan-Doh, N.; Ren, J.; Grutzner, S.; Beier, K.; Kim, T.; Schnitzer, M.; Luo, L.

10.1101/2021.02.15.431339 — neuroscience — Posted on 2021-02-16

2029 Simulating the emergence of the Visual Word Form Area: Recycling a convolutional neural network for reading

Hannagan, T.; Agrawal, A.; Cohen, L.; Dehaene, S.

10.1101/2021.02.15.431235 — neuroscience — Posted on 2021-02-16

2030 Predictive coding is a consequence of energy efficiency in recurrent neural networks

Ali, A.; Ahmad, N.; de Groot, E.; van Gerven, M. A. J.; Kietzmann, T. C.

10.1101/2021.02.16.430904 — neuroscience — Posted on 2021-02-16

2031 Two distinct neuronal populations in the rat parafascicular nucleus oppositely encode the engagement in stimulus-driven reward-seeking

Sicre, M.; Meffre, J.; Ambroggi, F.

10.1101/2021.02.14.431166 — neuroscience — Posted on 2021-02-16

2032 Optical activation of TrkB neurotrophin receptor in mouse ventral hippocampus promotes plasticity and facilitates fear extinction

Umemori, J.; Didio, G.; Winkel, F.; Pou, M. L.; Harkki, J.; Russo, G. L.; Verie, M.; Antila, H.; Buj, C.; Taira, T.; Lauri, S. E.; Guirado, R.; Castren, E.

10.1101/2021.02.14.431126 — neuroscience — Posted on 2021-02-16

2033 StrainGE: A toolkit to track and characterize low-abundance strains in complex microbial communities

van Dijk, L. R.; Walker, B. J.; Straub, T. J.; Worby, C. J.; Grote, A.; Schreiber, H. L.; Anyansi, C.; Pickering, A. J.; Hultgren, S. J.; Manson, A. L.; Abeel, T.; Earl, A. M.

10.1101/2021.02.14.431013 — bioinformatics — Posted on 2021-02-16

2034 COMPMAP: an allele-specific expression read-counter based on competitive mapping

Sanchez-Ramirez, S.; Cutter, A. D.

10.1101/2021.02.12.431019 — bioinformatics — Posted on 2021-02-16

2035 FORUM: Building a Knowledge Graph from public databases and scientific literature to extract associations between chemicals and diseases

Delmas, M.; Filangi, O.; Paulhe, N.; Vinson, F.; Duperier, C.; Garrier, W.; Saunier, P.- E.; Pitarch, Y.; Jourdan, F.; Giacomoni, F.; Frainay, C.

10.1101/2021.02.12.430944 — bioinformatics — Posted on 2021-02-16

2036 Attentional Modulations of Alpha Power Are Sensitive to the Task-relevance of Auditory Spatial Information

Klatt, L.-I.; Getzmann, S.; Schneider, D.

10.1101/2021.02.12.430942 — neuroscience — Posted on 2021-02-16

2037 Rheb-mTOR Activation Rescues Amyloid Beta-Induced Cognitive Impairment and Memory Function by Restoring miR-146 Activity in Glial Cells

De, D.; Mukherjee, I.; Guha, S.; Paidi, R. K.; Chakrabarti, S.; Biswas, S. C.; Bhattacharyya, S. N.

10.1101/2021.02.11.430878 — neuroscience — Posted on 2021-02-16

2038 Rapid processing and quantitative evaluation of multicontrast EPImix scans for adaptive multimodal imaging

Vasa, F.; Hobday, H.; Stanyard, R. A.; Daws, R. E.; Giampietro, V.; ODaly, O.; Lythgoe, D. J.; Seidlitz, J.; Skare, S.; Williams, S. C. R.; Marquand, A. F.; Leech, R.; Cole, J. H.

10.1101/2021.02.12.430956 — neuroscience — Posted on 2021-02-16

2039 Revealing the Physiological Origin of Event-Related Potentials using Electrocorticography in Humans

Cho, H.; Schalk, G.; Adamek, M.; Moheimanian, L.; Coon, W. G.; Jun, S. C.; Wolpaw, J. R.; Brunner, P.

10.1101/2021.02.12.430921 — neuroscience — Posted on 2021-02-16

2040 Characterizing white matter alterations in drug-naïve de novo Parkinsons disease with diffusion MRI

Xiao, Y.; Peters, T. M.; Khan, A. R.

10.1101/2021.02.13.431081 — neuroscience — Posted on 2021-02-16

2041 PolyA: a tool for adjudicating competing annotations of biological sequences

Carey, K. M.; Hubley, R.; Lesica, G. T.; Olson, D.; Roddy, J. W.; Rosen, J.; Shingleton, A.; Smit, A. F.; Wheeler, T. J.

10.1101/2021.02.13.430877 — bioinformatics — Posted on 2021-02-16

2042 DLAB - Deep learning methods for structure-based virtual screening of antibodies

Schneider, C.; Buchanan, A.; Taddese, B.; Deane, C. M.

10.1101/2021.02.12.430941 — bioinformatics — Posted on 2021-02-16

2043 A Guide to Pre-Processing High-Throughput Animal Tracking Data

Gupte, P. R.; Beardsworth, C. E.; Spiegel, O.; Lourie, E.; Toledo, S.; Nathan, R.; Bijleveld, A. I.

10.1101/2020.12.15.422876 — ecology — Posted on 2021-02-16

2044 Helicase-Like Functions in Phosphate Loop Containing Beta-Alpha Polypeptides

Vyas, P.; Trofimyuk, O.; Longo, L. M.; Deshmukh, F. K.; Sharon, M.; Tawfik, D. S.

10.1101/2020.07.30.228619 — molecular biology — Posted on 2021-02-16

2045 Attention to speech: Mapping distributed and selective attention systems

Agmon, G.; Yahav, P. H.-S.; Ben-Shachar, M.; Golumbic, E. Z.

10.1101/2021.02.13.431098 — neuroscience — Posted on 2021-02-16

2046 Developmental change in prefrontal cortex recruitment supports the emergence of value-guided memory

Nussenbaum, K.; Hartley, C. A.

10.1101/2021.02.13.431073 — neuroscience — Posted on 2021-02-16

2047 Effect of ozone exposure on Amyotrophic Lateral Sclerosis (ALS) pathology using a mice model of TDP-43 proteinopathy

Rodriguez, A.; Ferrer-Donato, A.; Cabrera-Pinto, M.; Sesena, S.; Fernandez, P.; Aranda, A.; Fernandez-Martos, C. M.

10.1101/2021.02.12.430915 — neuroscience — Posted on 2021-02-16

2048 Dynamic Representation of the Subjective Value of Information

Kobayashi, K.; Lee, S.; Filipowicz, A. L. S.; McGaughey, K. D.; Kable, J. W.; Nassar, M. R.

10.1101/2021.02.12.431038 — neuroscience — Posted on 2021-02-16

2049 Intron-mediated induction of phenotypic heterogeneity

Lukacisin, M.; Espinosa-Cantu, A.; Bollenbach, T.

10.1101/2021.01.19.427159 — systems biology — Posted on 2021-02-16

2050 The Progenetix oncogenomic resource in 2021

Huang, Q.; Carrio Cordo, P.; Gao, B.; Paloots, R.; Baudis, M.

10.1101/2021.02.15.428237 — cancer biology — Posted on 2021-02-16

2051 Removal of disulfide from acid stress chaperone HdeA does not wholly eliminate structure or function at low pH

Aguirre Cardenas, M. I.; Geddes-Buehre, D. H.; Crowhurst, K. A.

10.1101/2021.01.17.427034 — biophysics — Posted on 2021-02-16

2052 GRIDSS2: comprehensive characterisation of somatic structural variation using single breakend variants and structural variant phasing

Cameron, D. L.; Baber, J.; Shale, C.; Valle-Inclan, J. E.; Besselink, N.; Cuppen, E.; Priestley, P.; Papenfuss, A. T.

10.1101/2020.07.09.196527 — bioinformatics — Posted on 2021-02-16

2053 Triku: a feature selection method based on nearest neighbors for single-cell data

Ascension, A. M.; Ibanez-Sole, O.; Inza, I.; Izeta, A.; Arauzo-Bravo, M. J.

10.1101/2021.02.12.430764 — bioinformatics — Posted on 2021-02-16

2054 A cross-nearest neighbor/Monte Carlo algorithm for single molecule localization microscopy defines interactions between p53, Mdm2, and MEG3

Bauer, N. C.; Yang, A.; Wang, X.; Zhou, Y.; Klibanski, A.; Soberman, R. J.

10.1101/857912 — cell biology — Posted on 2021-02-16

2055 NDI: A platform-independent data interface and database for neuroscience physiology and imaging experiments

Garcia Murillo, D.; Rogovin, O.; Zhao, Y.; Chen, S.; Wang, Z.; Keeley, Z. C.; Shin, D. I.; Suarez Casanova, V. M.; Zhu, Y.; Martin, L.; Papaemmanouil, O.; Van Hooser, S. D.

10.1101/2020.05.13.093542 — neuroscience — Posted on 2021-02-16

2056 A brain-based universal measure of attention: predicting task-general and task-specific attention performance and their underlying neural mechanisms from task and resting state fMRI

Yoo, K.; Rosenberg, M. D.; Kwon, Y. H.; Avery, E. W.; Lin, Q.; Scheinost, D.; Constable, R. T.; Chun, M. M.

10.1101/2021.02.13.431091 — neuroscience — Posted on 2021-02-16

2057 The Future is Less Concrete than the Present: A Neural Signature of the Concreteness of Prospective Thought Is Modulated by Temporal Proximity during Intertemporal Decision-Making

Lee, S.; Parthasarathi, T.; Cooper, N.; Zauberman, G.; Lerman, C.; Kable, J. W.

10.1101/2021.02.13.431095 — neuroscience — Posted on 2021-02-16

2058 RAS specific protease Induces Irreversible Growth Arrest via p27 in several KRAS Mutant Colorectal Cancer cell lines

Stubbs, C. K.; Biancucci, M.; Vidimar, V.; Satchell, K. J. F.

10.1101/2020.12.08.416578 — cancer biology — Posted on 2021-02-16

2059 Simultaneous estimation of per cell division mutation rate and turnover rate from bulk tumour sequence data

Tibely, G.; Schrempf, D.; Derenyi, I.; Szöllosi, G. J.

10.1101/2021.02.12.430830 — bioinformatics — Posted on 2021-02-16

2060 Iron Responsive Element (IRE)-mediated responses to iron dyshomeostasis in Alzheimer's disease

Hin, N.; Newman, M.; Pederson, S.; Lardelli, M.

10.1101/2020.05.01.071498 — bioinformatics — Posted on 2021-02-16

2061 Molecular epidemiology of human respiratory syncytial virus with severe acute respiratory infection in Huzhou from 2016 to 2019

Chen, L.; Xu, D.; Ji, L.; Wu, X.; Wei, Y.

10.1101/2021.02.15.431241 — molecular biology — Posted on 2021-02-15

2062 Coding of chromatic spatial contrast by macaque V1 neurons

De, A.; Horwitz, G. D.

10.1101/2021.02.12.430975 — neuroscience — Posted on 2021-02-15

2063 Burst Control

Leleo, E. G.; Segev, I.

10.1101/2021.02.13.431061 — neuroscience — Posted on 2021-02-15

2064 Impaired clock gene expression and abnormal diurnal regulation of hippocampal inhibitory transmission and spatial memory in a mouse model of Alzheimers disease

Fusilier, A. R.; Davis, J. A.; Paul, J. R.; Yates, S. D.; McMeekin, L. J.; Goode, L. K.; Mokashi, M. V.; van Groen, T.; Cowell, R. M.; McMahon, L. L.; Roberson, E. D.; Gamble, K. L.

10.1101/2021.02.12.430852 — neuroscience — Posted on 2021-02-15

2065 Automated in vivo tracking of cortical oligodendrocytes

Xu, Y. K. T.; Call, C. L.; Sulam, J.; Bergles, D. E.

10.1101/2021.02.12.430879 — neuroscience — Posted on 2021-02-15

2066 Ongoing habenular activity is driven by forebrain networks and modulated by olfactory stimuli

Bartoszek, E. M.; Jetti, S. K.; Chau, K. T. P.; Yaksi, E.

10.1101/2021.02.14.431141 — neuroscience — Posted on 2021-02-16

2067 Metaplasia of respiratory and digestive tissues in the Eastern oyster Crassostrea virginica associated with the Deepwater Horizon oil spill

Roopnarine, D.; Roopnarine, P.; Anderson, L.; Hwang, J. H.; Patel, S.

10.1101/2021.02.15.431248 — zoology — Posted on 2021-02-15

2068 Consumer risk perception towards pesticides stained tomatoes in Uganda.

Sekabojja, D.; Atuhaire, A.; Nabankema, V.; Sekimpi, D.; Jors, E.

10.1101/2021.02.15.431249 — animal behavior and cognition — Posted on 2021-02-15

2069 Comparative genome analysis revealed gene inversions, boundary expansion and contraction, and gene loss in Stemona sessilifolia (Miq.) Miq. chloroplast genome

Liu, J.; Jiang, M.; Chen, H.; Liu, Y.; Liu, C.; Wu, W.

10.1101/2021.02.15.431246 — genomics — Posted on 2021-02-15

2070 Saccharomyces cerevisiae deficient in the early anaphase release of Cdc14 can traverse anaphase I without ribosomal DNA disjunction and successfully complete meiosis

Yellman, C. M.

10.1101/2021.02.15.431250 — genetics — Posted on 2021-02-15

2071 A conserved role of the duplicated Masculinizer gene in sex determination of the Mediterranean flour moth, Ephestia kuehniella

Visser, S.; Volenikova, A.; Nguyen, P.; Verhulst, E. C.; Marec, F.

10.1101/2021.02.15.431251 — genetics — Posted on 2021-02-15

2072 SecSel, a new software tool for conservation prioritization that is applicable to ordinal-scale data for multiple biodiversity features

Takenaka, A.; Oguma, H.; Amagai, Y.; Ishihama, F.

10.1101/2021.02.15.431247 — ecology — Posted on 2021-02-15

2073 Hybrid Support Vector Regression Model and K-Fold Cross Validation for Water Quality Index Prediction in Langat River, Malaysia

Mamat, N.; Hamzah, F. M.; Jaafar, O.

10.1101/2021.02.15.431242 — ecology — Posted on 2021-02-15

2074 A deep learning model for fish classification base on DNA barcode

Jin, L.; Yu, J.; Yuan, X.; Du, X.

10.1101/2021.02.15.431244 — molecular biology — Posted on 2021-02-15

2075 Shared genetic influences on resting-state functional networks of the brain

Guimaraes, J. P. O. F. T.; Sprooten, E.; Beckmann, C. F.; Franke, B.; Bralten, J.

10.1101/2021.02.15.431231 — neuroscience — Posted on 2021-02-15

2076 Region-specific maladaptive gray matter myelination is associated with differential susceptibility to stress-induced behavior in male rodents and humans

Long, K. L. P.; Chao, L. L.; Kazama, Y.; An, A.; Hu, K. Y.; Peretz, L.; Muller, D. C. Y.; Roan, V. D.; Misra, R.; Toth, C. E.; Breton, J. M.; Casazza, W.; Mostafavi, S. M.; Huber, B. R.; Woodward, S. H.; Neylan, T. C.; Kaufer, D.

10.1101/2021.02.15.431176 — neuroscience — Posted on 2021-02-15

2077 A farewell to EQ: A new brain size measure for comparative primate cognition

van Schaik, C. P.; Triki, Z.; Bshary, R.; Heldstab, S. A.

10.1101/2021.02.15.431238 — animal behavior and cognition — Posted on 2021-02-15

2078 Clinical and Genetic insights in a tertiary care center cohort of patients with bicuspid aortic valve

THERON, A.; Touil, A.; Resseguier, N.; Collod-Beroud, G.; Norscini, G.; Simoni, A.-S.; Odelin, G.; HABIB, G.; Collart, F.; Zaffran, S.; Avierinos, J.-F.

10.1101/2021.02.15.431243 — genetics — Posted on 2021-02-15

2079 Mapping language and non-language cognitive deficits in post-stroke anomic aphasia

Akkad, H.; Hope, T.; Crinion, J.

10.1101/2021.02.15.431293 — neuroscience — Posted on 2021-02-15

2080 Soluble guanylate cyclase stimulation mitigates skeletal and cardiac muscle dysfunction in a mdx model of Duchenne muscular dystrophy

Zhang, L.; Xu, Y.; Yousefi, K.; Irion, C. I.; Alvarez, R. A.; Krishnan, S. M.; Stasch, J.-P.; Martinez, E. C.; Buys, E. S.; Sandner, P.; Shehadeh, L. A.; Percival, J. M.

10.1101/2021.02.14.431156 — physiology — Posted on 2021-02-15

2081 Expanding the MECP2 network using comparative genomics reveals potential therapeutic targets for Rett syndrome

Unterman, I.; Bloch, I.; Cazacu, S.; Kazimirsky, G.; Berman, B. P.; Ben-Zeev, B.; Brodie, C.; Tabach, Y.

10.1101/2021.02.14.431162 — bioinformatics — Posted on 2021-02-15

2082 Long-reads are revolutionizing 20 years of insect genome sequencing

Hotaling, S.; Sproul, J. S.; Heckenhauer, J.; Powell, A.; Larracuente, A. L.; Pauls, S. U.; Kelley, J. L.; Frandsen, P. B.

10.1101/2021.02.14.431146 — genomics — Posted on 2021-02-15

2083 Shrinkage Parameter Estimation in Penalized Logistic RegressionAnalysis of Case-Control Data

Yu, Y.; Chen, S.; McNeney, B.

10.1101/2021.02.12.430986 — genetics — Posted on 2021-02-15

2084 Eusociality through conflict dissolution

Gonzalez-Forero, M.; Pena, J.

10.1101/2020.09.29.316877 — evolutionary biology — Posted on 2021-02-15

2085 The evolution of social parasitism in Formica ants revealed by a global phylogeny

Borowiec, M. L.; Cover, S. P.; Rabeling, C.

10.1101/2020.12.17.423324 — evolutionary biology — Posted on 2021-02-15

2086 Multispecies site occupancy modeling and study design for spatially replicated environmental DNA metabarcoding

Fukaya, K.; Kondo, N. I.; Matsuzaki, S.-I. S.; Kadoya, T.

10.1101/2021.02.14.431192 — ecology — Posted on 2021-02-15

2087 Vertical stratification of environmental DNA in the open ocean captures ecological patterns and behavior of deep-sea fishes

Canals, O.; Mendibil, I.; Santos, M.; Irigoien, X.; Rodriguez-Ezpeleta, N.

10.1101/2021.02.10.430594 — ecology — Posted on 2021-02-15

2088 Ultra-sensitive nanoLC-MS using second generation micro pillar array LC technology with Orbitrap Exploris 480 and FAIMS PRO to enable single cell proteomics

Stejskal, K.; Op de Beeck, J.; Dürnberger, G.; Jacobs, P.; Mechtler, K.

10.1101/2021.02.10.430648 — cell biology — Posted on 2021-02-15

2089 Microbiota-derived metabolites inhibit Salmonella virulent subpopulation development by acting on single-cell behaviors

Hockenberry, A. M.; Micali, G.; Takacs, G.; Weng, J.; Hardt, W.-D.; Ackermann, M.

10.1101/2021.02.14.430798 — microbiology — Posted on 2021-02-15

2090 Microbial tryptophan catabolism affects the vector competence of Anopheles

Feng, Y.; Peng, Y.; Wen, H.; Song, X.; An, Y.; Tang, H.; Wang, J.

10.1101/2021.02.15.431262 — microbiology — Posted on 2021-02-15

2091 Trade-offs between antiseptic cytotoxicity and efficacy in a human ex vivo wound contamination model

Cheong, A.; Liu, A.; Rust, C.; Kalan, L.; Gibson, A.

10.1101/2021.02.14.430155 — microbiology — Posted on 2021-02-15

2092 Broad-spectrum antiviral activity of 3D8, a nucleic acid-hydrolyzing single chain variable fragment (scFv), targeting SARS-CoV-2 and multiple coronaviruses in vitro

Lee, G.; Budhathoki, S.; Lee, G.-Y.; Oh, K.-j.; Ham, Y. K.; Kim, Y. J.; Lim, Y. R.; Hoang, P. T.; Lee, Y.; Lim, S.-W.; Kim, J.-M.; Cho, S.; Kim, T.-H.; Song, J.-W.; Lee, S.; Kim, W.-K.

10.1101/2020.11.25.398909 — microbiology — Posted on 2021-02-15

2093 Assessment of the reproducibility and inter-site transferability of the murine direct splenocyte mycobacterial growth inhibition assay (MGIA)

Tanner, R.; Zelmer, A.; Painter, H.; Stylianou, E.; Pinpathomrat, N.; Harrington-Kandt, R.; Biffar, L.; Brennan, M. J.; McShane, H.; Fletcher, H. A.

10.1101/2021.02.14.431105 — immunology — Posted on 2021-02-15

2094 AAV-Mediated In Vivo CAR Gene Therapy for Targeting Human T Cell Leukemia

Nawaz, W.; Huang, B.; Xu, S.; Li, Y.; Zhu, L.; wu, x.; Wu, Z.

10.1101/2021.02.15.431201 — immunology — Posted on 2021-02-15

2095 c-Rel is required for IL-33-dependent activation of ILC2s

Zaini, A.; Fulford, T.; Grumont, R.; Runting, J.; Rodrigues, G.; Ng, J.; Gerondakis, S.; Zaph, C.; Scheer, S.

10.1101/2021.02.14.431188 — immunology — Posted on 2021-02-15

2096 Analysis of Hippocampal Subfields in Sickle Cell Disease Using Ultrahigh Field MRI

Santini, T.; Koo, M.; Farhat, N.; Campos, V. P.; Alkhateeb, S.; Vieira, M. A. C.; Butters, M. A.; Rosano, C.; Aizenstein, H. J.; Mettenburg, J.; Novelli, E. M.; Ibrahim, T. S.

10.1101/2020.11.10.377564 — neuroscience — Posted on 2021-02-15

2097 Differential role of type I and type II vestibular hair cells in two anti-gravity reflexes in the rat.

Maroto, A. F.; Barrallo-Gimeno, A.; Llorens, J.

10.1101/2020.12.21.423804 — neuroscience — Posted on 2021-02-15

2098 GABA levels in ventral visual cortex decline with age and are associated with neural distinctiveness

Chamberlain, J. D.; Gagnon, H.; Lalwani, P.; Cassady, K. E.; Simmonite, M.; Seidler, R. D.; Taylor, S. F.; Weissman, D. H.; Park, D. C.; Polk, T. A.

10.1101/743674 — neuroscience — Posted on 2021-02-15

2099 Short-term plasticity persists in the absence of PKC phosphorylation of Munc18-1

Wang, C.-C.; Weyrer, C.; Fioravante, D.; Kaeser, P. S.; Regehr, W. G.

10.1101/2021.02.14.431144 — neuroscience — Posted on 2021-02-15

2100 Regulatory adenylnucleotide-mediated binding of the PII-like protein SbtB to the cyanobacterial bicarbonate transporter SbtA is controlled by the cellular energy state

Foerster, B.; Mukherjee, B.; Rourke, L.; Kaczmarski, J. A.; Jackson, C. J.; Price, G. D.

10.1101/2021.02.14.431189 — plant biology — Posted on 2021-02-15

2101 Genetic and gene expression analysis of flowering time regulation by light quality in lentil

Yuan, H. Y.; Caron, C. T.; Ramsay, L.; Fratini, R.; Perez de la Vega, M.; Vandenberg, A.; Weller, J. L.; Bett, K. E.

10.1101/2021.02.14.429948 — plant biology — Posted on 2021-02-15

2102 Cutevariant: a GUI-based desktop application to explore genetics variations

Schutz, S.; Marijon, P.; Montier, T.; Genin, E.

10.1101/2021.02.10.430619 — bioinformatics — Posted on 2021-02-15

2103 Spatially Interacting Phosphorylation Sites and Mutations in Cancer

Huang, K.-l.; Scott, A.; Zhou, D. C.; Wang, L.-b.; Weerasinghe, A.; Elmas, A.; Liu, R.; Wu, Y.; Wendl, M.; Wyczalkowski, M.; Baral, J.; Sengupta, S.; Lai, C.-W.; Ruggles, K.; Payne, S.; Raphael, B.; Fenyo, D.; Chen, K.; Mills, G.; Ding, L.

10.1101/2021.02.14.431184 — bioinformatics — Posted on 2021-02-15

2104 Functional Near Infrared Spectroscopy (fNIRS) based Odor Detection and Classification using Functional Data Analysis

Moradi, F.; Pourrezaei, K.

10.1101/2021.02.13.431051 — bioinformatics — Posted on 2021-02-15

2105 Flexible analysis of TSS mapping data and detection of TSS shifts with TSRexploreR

Policastro, R. A.; McDonald, D. J.; Brendel, V. P.; Zentner, G. E.

10.1101/2021.02.14.431114 — bioinformatics — Posted on 2021-02-15

2106 Hybrid Clustering of single-cell gene-expression and cell spatial information via integrated NMF and k-means

Oh, S.; Park, H.; Zhang, X.

10.1101/2020.11.15.383281 — bioinformatics — Posted on 2021-02-15

2107 Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphoma

Ma, M. C. J.; Tadros, S.; Bouska, A.; Heavican, T.; Yang, H.; Deng, Q.; Moore, D.; Akhter, A.; Hartert, K.; Jain, N.; Showell, J.; Ghosh, S.; Street, L.; Davidson, M.; Carey, C.; Tobin, J.; Perumal, D.; Vose, J.; Lunning, M.; Sohani, A.; Chen, B.; Buckley, S.; Nastoupil, L.; Davis, R. E.; Westin, J.; Fowler, N.; Parekh, S.; Gandhi, M.; Neelapu, S.; Stewart, D.; Iqbal, J.; Rodig, S.; Mansoor, A.; Green, M.

10.1101/674259 — genomics — Posted on 2021-02-15

2108 Optimizing experimental design for genome sequencing and assembly with Oxford Nanopore Technologies

Sutton, J. M.; Millwood, J. D.; McCormack, A. C.; Fierst, J. L.

10.1101/2020.05.05.079327 — genomics — Posted on 2021-02-15

2109 Genome-wide Identification of the Genetic Basis of Amyotrophic Lateral Sclerosis

Zhang, S.; Cooper-Knock, J.; Weimer, A. K.; Shi, M.; Moll, T.; Harvey, C.; Nezhad, H. G.; Franklin, J.; Souza, C. d. S.; Wang, C.; Li, J.; Elhaik, E.; Eitan, C.; Hornstein, E.; Kenna, K. P.; Project MinE Sequencing Consortium, ; Veldink, J.; Ferraiuolo, L.; Shaw, P. J.; Snyder, M. P.

10.1101/2020.11.14.382606 — genomics — Posted on 2021-02-15

2110 Different evolutionary trends form the twilight zone of the bacterial pan-genome

Horesh, G.; Taylor-Brown, A.; McGimpsey, S.; Lasalle, F.; Corander, J.; Heinz, E.; Thomson, N. R.

10.1101/2021.02.15.431222 — genomics — Posted on 2021-02-15

2111 Calling differential DNA methylation at cell-type resolution: addressing misconceptions and best practices

Rahmani, E.; Jew, B.; Schweiger, R.; Rhead, B.; Criswell, L. A.; Barcellos, L. F.; Eskin, E.; Rosset, S.; Sankararaman, S.; Halperin, E.

10.1101/2021.02.14.431168 — genomics — Posted on 2021-02-15

2112 Broad geographic sampling reveals predictable, pervasive, and strong seasonal adaptation in Drosophila

Machado, H.; Bergland, A. O.; Taylor, R.; Tilk, S.; Behrman, E.; Dyer, K.; Fabian, D.; Flatt, T.; Gonzalez, J.; Karasov, T.; Kozeretska, I.; Lazzaro, B. P.; Merritt, T.; Pool, J.; O'Brien, K.; Rajpurohit, S.; Roy, P.; Schaeffer, S.; Serga, S.; Schmidt, P.; Petrov, D.

10.1101/337543 — evolutionary biology — Posted on 2021-02-15

2113 Gene co-expression network reveals highly conserved, well-regulated anti-ageing mechanisms in old ant queens.

Harrison, M. C.; Jaimes Nino, L. M.; Almeida Rodrigues, M.; Ryll, J.; Flatt, T.; Oettler, J.; Bornberg-Bauer, E.

10.1101/2021.02.14.431190 — evolutionary biology — Posted on 2021-02-15

2114 The genetic architecture and genomic context of glyphosate resistance in Amaranthus tuberculatus

Kreiner, J. M.; Tranel, P. M.; Weigel, D.; Stinchcombe, J. R.; Wright, S.

10.1101/2020.08.19.257972 — evolutionary biology — Posted on 2021-02-15

2115 A global indicator of utilised wildlife populations: regional trends and the impact of management

McRae, L.; Freeman, R.; Geldmann, J.; Moss, G. B.; Kjaer-Hansen, L.; Burgess, N. D.

10.1101/2020.11.02.365031 — ecology — Posted on 2021-02-15

2116 Distribution of Panama's narrow-range trees: are there hot-spots?

Tokarz, E.; Condit, R.

10.1101/2021.02.13.431023 — ecology — Posted on 2021-02-15

2117 Are irrigated urban trees more sensitive to light and temperature than water?

Griffin, K. L.; Harris, T. G.; Bruner, S.; McKenzie, P. F.; Hise, J.

10.1101/2020.10.29.361121 — ecology — Posted on 2021-02-15

2118 Melanoma cells adopt features of both mesenchymal and amoeboid migration within confining channels

Gabbireddy, S. R.; Chung, A. J.; Logue, J. S.

10.1101/2021.02.12.431031 — cell biology — Posted on 2021-02-15

2119 Emerin oligomerization and nucleoskeletal coupling at the nuclear envelope regulate nuclear mechanics against stress

Fernandez, A. M.; Bautista, M.; Pinaud, F.

10.1101/2021.02.12.429834 — cell biology — Posted on 2021-02-15

2120 SARS-CoV2 envelop proteins reshape the serological responses of COVID-19 patients

Martin, S.; Heslan, C.; Jegou, G.; Eriksson, L. A.; Le Gallo, M.; Thibault, V.; Chevet, E.; Avril, T.

10.1101/2021.02.15.431237 — cell biology — Posted on 2021-02-15

2121 Bromodomain and Extraterminal Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV-2 Infection (Pre-Clinical)

Mills, R. J.; Humphrey, S. J.; Fortuna, P. R.; Lor, M.; Foster, S. R.; Quaife-Ryan, G. A.; Johnston, R. L.; Dumenil, T.; Bishop, C.; Ruraraju, R.; Rawle, D. J.; Le, T.; Zhao, W.; Lee, L.; Mackenzie-Kludas, C.; Mehdiabadi, N. R.; Halliday, C.; Gilham, D.; Fu, L.; Nicholls, S. J.; Johansson, J.; Sweeney, M.; Wong, N. C. W.; Kulikowski, E.; Sokolowski, K.; Tse, B. W. C.; Devilee, L.; Voges, H. K.; Reynolds, L. T.; Krumeich, S.; Mathieson, E.; Abu-Bonsrah, D.; Karavendzas, K.; Griffen, B.; Titmarsh, D. M.; Elliott, D. A.; McMahon, J. H.; Suhrbier, A.; Subbarao, K.; Porrello, E. R.; Smyth, M. J.; E

10.1101/2020.08.23.258574 — cell biology — Posted on 2021-02-15

2122 ToxCast chemical library screen identifies diethanolamine as an activator of Wnt signaling

Wolter, J. M.; Jimenez, J.; Stein, J. L.; Zylka, M. J.

10.1101/2021.02.15.430319 — molecular biology — Posted on 2021-02-15

2123 Parasite co-opts a ubiquitin receptor to induce a plethora of developmental changes

Huang, W.; MacLean, A.; Sugio, A.; Maqbool, A.; Busscher, M.; Cho, S.-T.; Kamoun, S.; Kuo, C.-H.; Immink, R. G. H.; Hogenhout, S. A.

10.1101/2021.02.15.430920 — molecular biology — Posted on 2021-02-15

2124 Assessment of the suitability of marker fragments DNA sequences of the internal transcribed spacer region (ITS), beta-tubulin gene (TUB) and elongation factor (EF1) genes for diagnostics of Fusarium tricinctum species complex in Russian in grain products

Shchukovskaia, A.

10.1101/2021.02.15.431223 — molecular biology — Posted on 2021-02-15

2125 Comparison of library preparation and sequencing depths for direct sequencing of Bordetella pertussis positive samples

Fong, W.; Pey, K.; Rockett, R.; Sadsad, R.; Sintchenko, V.; Timms, V.

10.1101/2021.02.14.430694 — microbiology — Posted on 2021-02-15

2126 Coordination between nucleotide excision repair and specialized polymerase DnaE2 action enables DNA damage survival in non-replicating bacteria

Joseph, A. M.; Daw, S.; Sadhir, I.; Badrinarayanan, A.

10.1101/2021.02.15.431208 — microbiology — Posted on 2021-02-15

2127 In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia

Cole, B.; Lambrechts, L.; Gantner, P.; Noppe, Y.; Bonine, N.; Witkowski, W.; Chen, L. H.; Palmer, S.; Mullins, J. I.; Chomont, N.; Pardons, M.; Vandekerckhove, L.

10.1101/2021.02.15.431218 — microbiology — Posted on 2021-02-15

2128 SARS CoV-2 nucleoprotein enhances the infectivity of lentiviral spike particles

Mishra, T.; M, S.; Ramdas, P.; Sahu, A. K.; Kumar, A.; Chande, A.

10.1101/2021.02.11.430757 — microbiology — Posted on 2021-02-15

2129 A quantitative measure of functional redundancy in microbial ecosystems

Royalty, T. M.; Steen, A. D.

10.1101/2020.04.22.054593 — microbiology — Posted on 2021-02-15

2130 Phyletic distribution and diversification of the Phage Shock Protein stress response system in bacteria and archaea

Popp, P. F.; Gumerov, V. M.; Andrianova, E. P.; Bewersdorf, L.; Mascher, T.; Jouline, I.; Wolf, D.

10.1101/2021.02.15.431232 — microbiology — Posted on 2021-02-15

2131 The dynamic transition of persistence towards the VBNC state during stationary phase is driven by protein aggregation

Dewachter, L.; Bollen, C.; Wilmaerts, D.; Louwagie, E.; Herpels, P.; Matthay, P.; Khodaparast, L.; Khodaparast, L.; Rousseau, F.; Schymkowitz, J.; Michiels, J.

10.1101/2021.02.15.431274 — microbiology — Posted on 2021-02-15

2132 PD-1-induced T cell exhaustion is controlled by a Drp1-dependent mechanism

Simula, L.; Cancila, V.; Antonucci, Y.; Colamatteo, A.; Procaccini, C.; Matarese, G.; Tripodo, C.; Campello, S.

10.1101/2020.07.14.200592 — immunology — Posted on 2021-02-15

2133 Neuronal variability reflects probabilistic inference tuned to natural image statistics

Festa, D.; Aschner, A.; Davila, A.; Kohn, A.; Coen-Cagli, R.

10.1101/2020.06.17.142182 — neuroscience — Posted on 2021-02-15

2134 NMDA receptor-BK channel coupling regulates synaptic plasticity in the barrel cortex

Gomez, R.; Maglio, L. E.; Gonzalez-Hernandez, A. J.; Rivero-Perez, B.; Bartolome-Martin, D.; Giraldez, T.

10.1101/2020.12.30.424719 — neuroscience — Posted on 2021-02-15

2135 Sphingosine kinase 2 is essential for remyelination following cuprizone intoxication

Song, H.; McEwen, H. P.; Duncan, T.; Teo, J. D.; Don, A. S.

10.1101/2021.02.14.431183 — neuroscience — Posted on 2021-02-15

2136 Ongoing habenular activity is driven by forebrain networks and modulated by olfactory stimuli

Bartoszek, E. M.; Jetti, S. K.; Chau, K. T. P.; Yaksi, E.

10.1101/2021.02.14.431141 — neuroscience — Posted on 2021-02-15

2137 CGRP-receptor family reveals endogenous GPCR agonist bias and its significance in primary human cardiovascular cells

Clark, A.; Mullooly, N.; Safitri, D.; Harris, M.; de Vries, T.; Van Den Brink, A. M.; Poyner, D. R.; Gianni, D.; Wigglesworth, M.; Ladds, G.

10.1101/2020.12.21.423730 — pharmacology and toxicology — Posted on 2021-02-15

2138 Quantifying and Mitigating Motor Phenotypes Induced by Antisense Oligonucleotides in the Central Nervous System

Moazami, M. P.; Rembetsy-Brown, J. M.; Wang, F.; Krishnamurthy, P. M.; Weiss, A.; Marosfoi, M.; King, R. M.; Motwani, M.; Gray-Edwards, H.; Fitzgerald, K. A.; Brown, R. H.; Watts, J. K.

10.1101/2021.02.14.431096 — pharmacology and toxicology — Posted on 2021-02-15

2139 Microsecond resolved infrared spectroscopy on non-repetitive protein reactions by applying caged-compounds and quantum cascade laser frequency combs

Norahan, M. J.; Horvath, R.; Woitzik, N.; Jouy, P.; Eigenmann, F.; Gerwert, K.; Koetting, C.

10.1101/2021.01.04.425172 — biophysics — Posted on 2021-02-15

2140 Identification of chromatin loops from Hi-C interaction matrices by CTCF-CTCF topology classification

Galan, S.; Serra, F.; Marti-Renom, M. A.

10.1101/2020.07.21.214585 — bioinformatics — Posted on 2021-02-15

2141 Jumper Enables Discontinuous Transcript Assembly in Coronaviruses

Sashittal, P.; Zhang, C.; Peng, J.; El-Kebir, M.

10.1101/2021.02.12.431026 — bioinformatics — Posted on 2021-02-15

2142 eQTpLot: a user-friendly R package for the visualization and colocalization of eQTL and GWAS signals

Drivas, T. G.; Lucas, A.; Ritchie, M. D.

10.1101/2020.08.26.268268 — bioinformatics — Posted on 2021-02-15

2143 Traces of transposable element in genome dark matter co-opted by flowering gene regulation networks.

Baud, A.; Wan, M.; Nouaud, D.; Francillonne, N.; Anxolabehere, D.; Quesneville, H.

10.1101/547877 — genomics — Posted on 2021-02-15

2144 SARS-CoV-2 and SARS-CoV spike-mediated cell-cell fusion differ in the requirements for receptor expression and proteolytic activation

Hörnich, B. F.; Grosskopf, A. K.; Schlagowski, S.; Tenbusch, M.; Kleine-Weber, H.; Neipel, F.; Stahl-Hennig, C.; Hahn, A. S.

10.1101/2020.07.25.221135 — microbiology — Posted on 2021-02-15

2145 Cerebellar lesions disrupt spatial and temporal visual attention.

Craig, B. T.; Morrill, A.; Anderson, B.; Danckert, J.; Striemer, C. L.

10.1101/822635 — neuroscience — Posted on 2021-02-15

2146 Betacoronavirus binding dynamics relevant to the functional evolution of the highly transmissible SARS-CoV-2 variant N501Y

Rynkiewicz, P.; Babbitt, G. A.; Cui, F.; Hudson, A. O.; Lynch, M. L.

10.1101/2020.09.11.293258 — biophysics — Posted on 2021-02-15

2147 A benchmarking of human mitochondrial DNA haplogroup classifiers from whole-genome and whole-exome sequence data

Garcia-Olivares, V.; Munoz-Barrera, A.; Lorenzo-Salazar, J. M.; Zaragoza-Trello, C.; Rubio-Rodriguez, L. A.; Diaz-de Usera, A.; Jaspez, D.; Inigo-Campos, A.; Gonzalez-Montelongo, R.; Flores, C.

10.1101/2021.02.11.430775 — genomics — Posted on 2021-02-15

2148 Targeting androgen regulation of TMPRSS2 and ACE2 as a therapeutic strategy to combat COVID-19

Deng, Q.; Rasool, R. u.; Russell, R. M.; Natesan, R.; Asangani, I. A.

10.1101/2020.10.16.342782 — molecular biology — Posted on 2021-02-15

2149 Sequential infection with influenza A virus followed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to more severe disease and encephalitis in a mouse model of COVID-19.

Clark, J. J.; Penrice-Randal, R.; Sharma, P.; Kipar, A.; Dong, X.; Pennington, S.; Marriott, A. E.; Colombo, S.; Davidson, A. D.; Kavanagh Williamson, M.; Matthews, D. A.; Turtle, L.; Prince, T.; Hughes, G.; Patterson, E. I.; Shawli, G.; Subramaniam, K.; Sharp, J.; McLaughlin, L.; Zhou, E.-M.; Turner, J. D.; Biagini, G.; Owen, A.; Hiscox, J. A.; Stewart, J. P.

10.1101/2020.10.13.334532 — microbiology — Posted on 2021-02-15

2150 Immunological and cardio-vascular pathologies associated with SARS-CoV-2 infection in golden syrian hamster

Rizvi, Z. A.; Dalal, R.; Sadhu, S.; Kumar, Y.; Shrivastava, T.; Gupta, S. K.; Aggarwal, S.; Tripathy, M. R.; Yadav, A. K.; Medigeshi, G. R.; Pandey, A. K.; Samal, S.; Asthana, S.; Awasthi, A.

10.1101/2021.01.11.426080 — microbiology — Posted on 2021-02-15

2151 Complete Protection of Nasal and Lung Airways Against SARS-CoV-2 Challenge by Antibody Plus Th1 Dominant N- and S-Specific T-Cell Responses to Subcutaneous Prime and Thermally-Stable Oral Boost Bivalent hAd5 Vaccination in an NHP Study

Gabitzsch, E.; Safrit, J. T.; Verma, M.; Rice, A.; Sieling, P.; Zakin, L.; Shin, A.; Morimoto, B.; Adisetiyo, H.; Wong, R.; Bezawada, A.; Dinkins, K.; Balint, J.; Peykov, V.; Garban, H.; Liu, P.; Bacon, A.; Drew, J.; Sanford, D. C.; Spilman, P.; Sender, L.; Rabizadeh, S.; Niazi, K.; Soon-Shiong, P.

10.1101/2020.12.08.416297 — immunology — Posted on 2021-02-15

2152 A counterintuitive method for slowing down an analyte in a nanopore and its application to polymer sequencing

Sampath, G.

10.1101/2021.01.11.426231 — bioengineering — Posted on 2021-02-15

2153 Pulled Diversification Rates, Lineages-Through-Time Plots and Modern Macroevolutionary Modelling

Helmstetter, A. J.; Glemin, S.; Kafer, J.; Zenil-Ferguson, R.; Sauquet, H.; de Boer, H.; Dagallier, L.-P. M.; Mazet, N.; Reboud, E. L.; Couvreur, T. L.; Condamine, F. L.

10.1101/2021.01.04.424672 — evolutionary biology — Posted on 2021-02-15

2154 The beta component of gamma-band auditory steady-state responses in patients with schizophrenia

Metzner, C.; Steuber, V.

10.1101/2021.02.01.429120 — neuroscience — Posted on 2021-02-15

2155 Conditional distribution modeling as an alternative method for covariates simulation: comparison with joint multivariate normal and bootstrap techniques

Smania, G.; Jonsson, N. E.

10.1101/2020.11.01.363325 — pharmacology and toxicology — Posted on 2021-02-15

2156 The Progenetix oncogenomic resource in 2021

Huang, Q.; Carrio Cordo, P.; Gao, B.; Paloots, R.; Baudis, M.

10.1101/2021.02.15.428237 — cancer biology — Posted on 2021-02-15

2157 Publicly available transcriptomes provide the opportunity for dual RNA-Seq meta analysis in Plasmodium infection

Mukherjee, P.; Burgio, G.; Heitlinger, E.

10.1101/576116 — bioinformatics — Posted on 2021-02-15

2158 A developmental framework linking neurogenesis and circuit formation in the Drosophila CNS

Mark, B.; Lai, S.-L.; Arzan Zarin, A.; Manning, L.; Litwin-Kumar, A.; Cardona, A.; Truman, J. W.; Doe, C. Q.

10.1101/617936 — neuroscience — Posted on 2021-02-15

2159 An allosteric ligand stabilizes distinct conformations in the M2 muscarinic acetylcholine receptor

Xu, J.; Hubner, H.; Hu, Y.; Niu, X.; Gmeiner, P.; Jin, C.; Kobilka, B.

10.1101/2021.02.14.431178 — biophysics — Posted on 2021-02-15

2160 Loss of PABPC1 is compensated by elevated PABPC4 and correlates with transcriptome changes

Xie, J.; Wei, X.; Chen, Y.

10.1101/2021.02.07.430165 — biochemistry — Posted on 2021-02-15

2161 ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model

Vandyck, K.; Abdelnabi, R.; Gupta, K.; Jochmans, D.; Jekle, A.; Deval, J.; Misner, D.; Bardiot, D.; Foo, C. S.; Liu, C.; Ren, S.; Beigelman, L.; Blatt, L. M.; Boland, S.; Vangeel, L.; Dejonghe, S.; Chaltin, P.; Marchand, A.; Serebryany, V.; Stoycheva, A.; Chanda, S.; Symons, J. A.; Raboisson, P.; Neyts, J.

10.1101/2021.02.14.431129 — microbiology — Posted on 2021-02-15

2162 Pulsed broad-spectrum UV light effectively inactivates SARS-CoV-2 on multiple surfaces

Jureka, A. S.; Williams, C. G.; Basler, C. F.

10.1101/2021.02.12.431032 — microbiology — Posted on 2021-02-15

2163 Potent, Novel SARS-CoV-2 PLpro Inhibitors Block Viral Replication in Monkey and Human Cell Cultures

Shen, Z.; Ratia, K.; Cooper, L.; Kong, D.; Lee, H.; Kwon, Y.; Li, Y.; Alqarni, S.; Huang, F.; Dubrovskyi, O.; Rong, L.; Thatcher, G. R.; XIONG, R.

10.1101/2021.02.13.431008 — microbiology — Posted on 2021-02-15

2164 Direct activation of endothelial cells by SARS-CoV-2 nucleocapsid protein is blocked by Simvastatin

Qian, Y.; Lei, T.; Patel, P.; Lee, C.; Monaghan-Nichols, P.; Xin, H.-B.; Qiu, J.; Fu, M.

10.1101/2021.02.14.431174 — immunology — Posted on 2021-02-15

2165 Impact of Binge Drinking During College on Resting State Functional Connectivity

Tong, T. T.; Vaidya, J. G.; Kramer, J. R.; Kuperman, S.; Langbehn, D. R.; OLeary, D. S.

10.1101/2021.02.09.430381 — neuroscience — Posted on 2021-02-15

2166 Integument transcriptome profile of the European sea cucumber Holothuria forskali (Holothuroidea, Echinodermata)

Delroisse, J.; Bonneel, M.; Demeuldre, M.; Eeckhaut, I.; Flammang, P.

10.1101/2021.02.12.430961 — zoology — Posted on 2021-02-14

2167 Identification of phenotype-specific networks from paired gene expression-cell shape imaging data

Barker, C. G.; Petsalaki, E.; Giudice, G.; Ekpenyong, E. N.; Bakal, C.; Petsalaki, E.

10.1101/2021.02.11.430597 — systems biology — Posted on 2021-02-15

2168 picCASO: A Cellular Automaton for Spatial Organisation

Venkatraghavan, S.; Anantakrishnan, S.; Raman, K.

10.1101/2021.02.14.431138 — systems biology — Posted on 2021-02-15

2169 Protocell Arrays for Simultaneous Detection of Diverse Analytes

Zhang, Y.; Kojima, T.; Kim, G.-A.; McNerney, M. P.; Takayama, S.; Styczynski, M. P.

10.1101/2021.02.13.431022 — synthetic biology — Posted on 2021-02-15

2170 MSA Transformer

Rao, R.; Liu, J.; Verkuil, R.; Meier, J.; Canny, J. F.; Abbeel, P.; Sercu, T.; Rives, A.

10.1101/2021.02.12.430858 — synthetic biology — Posted on 2021-02-15

2171 Genie: An interactive real-time simulation for teaching genetic drift

Castillo, A. I.; Roos, B. H.; Rosenberg, M. S.; Cartwright, R. A.; Wilson, M. A.

10.1101/268672 — scientific communication and education — Posted on 2021-02-15

2172 GABA plays a key role in plant acclimation to a combination of high light and heat stress

Balfagon, D.; Gomez-Cadenas, A.; Rambla, J. L.; Granell, A.; de Ollas, C.; Mittler, R.; I Zandalinas, S.

10.1101/2021.02.13.431103 — plant biology — Posted on 2021-02-14

2173 Subcellular dynamics studies reveal how tissue-specific distribution patterns of iron are established in developing wheat grains

Sheraz, S.; Wan, Y.; Venter, E.; Verma, S. K.; Xiong, Q.; Waites, J.; Connorton, J. M.; Shewry, P. R.; Moore, K. L.; Balk, J.

10.1101/2021.02.14.431124 — plant biology — Posted on 2021-02-14

2174 Endothelial alpha globin is a nitrite reductase

Keller, T. C. S.; Keller, A. S.; Broseghini-Filho, G. B.; Butcher, J. T.; Askew Page, H. R.; Islam, A.; Tan, Z. Y.; DeLalio, L. J.; Lechauve, C.; Brooks, S. D.; Sharma, P.; Hong, K.; Xu, W.; Padilha, A. S.; Ruddiman, C. A.; Best, A. K.; Macal, E.; Kim-Shapiro, D.; Christ, G.; Yan, Z.; Cortese-Krott, M. M.; Ricart, K.; Patel, R. P.; Bender, T. P.; Sonkusare, S. K.; Weiss, M. J.; Ackerman, H.; Columbus, L.; Isakson, B. E.

10.1101/2021.02.12.430954 — physiology — Posted on 2021-02-14

2175 Impact of an oral amino acid provision on Achilles peritendinous amino acid concentrations in young and older adults

Carroll, C. C.; Couture, S.; Farino, D. O.; Patel, S. H.; Campbell, N. W.; Stout, J.; Sabbaghi, A.

10.1101/2021.02.12.430945 — physiology — Posted on 2021-02-14

2176 Stomach serosal arteries distinguish gastric regions of the rat

Jaffey, D. M.; Chesney, L.; Powley, T. L.

10.1101/2021.02.13.431085 — physiology — Posted on 2021-02-14

2177 In vitro efficacy of Artemisia extracts against SARS-CoV-2

Nie, C.; Trimpert, J.; Moon, S.; Haag, R.; Gilmore, K.; Kaufer, B. B.; Seeberger, P. H.

10.1101/2021.02.14.431122 — pharmacology and toxicology — Posted on 2021-02-15

2178 Epigenetic changes with age primes mammary luminal epithelia for cancer initiation

Sayaman, R. W.; Miyano, M.; Senapati, P.; Shalabi, S.; Zirbes, A.; Todhunter, M. E.; Seewaldt, V.; Neuhausen, S. L.; Stampfer, M. R.; Schones, D. E.; LaBarge, M. A.

10.1101/2021.02.12.430777 — cancer biology — Posted on 2021-02-13

2179 Invadopodia enable cooperative invasion and metastasis of breast cancer cells

Perrin, L.; Bayarmagnai, B.; Tuzel, E.; Gligorijevic, B.

10.1101/2021.02.13.431047 — cancer biology — Posted on 2021-02-14

2180 EZH2 Engages TGFβ Signaling to Promote Breast Cancer Bone Metastasis via Integrin β1-FAK Activation

Zhang, L.; Qu, J.; Qi, Y.; Huang, Y.-W.; Zhou, Z.; Li, P.; Yao, J.; Huang, B.; Zhang, S.; Yu, D.

10.1101/2021.02.14.431151 — cancer biology — Posted on 2021-02-14

2181 APOBEC mutagenesis inhibits breast cancer growth through induction of a T cell-mediated antitumor immune response

DiMarco, A. V.; Qin, X.; Van Alsten, S.; McKinney, B.; Garcia, N. M. G.; Force, J.; Hanks, B. A.; Troester, M. A.; Owzar, K.; Xie, J.; Alvarez, J. V.

10.1101/2021.02.13.431068 — cancer biology — Posted on 2021-02-14

2182 The APOBEC3A deaminase drives episodic mutagenesis in cancer cells

Petljak, M.; Chu, K.; Dananberg, A.; Bergstrom, E. N.; von Morgen, P.; Alexandrov, L.; Stratton, M. R.; Maciejowski, J.

10.1101/2021.02.14.431145 — cancer biology — Posted on 2021-02-14

2183 Medicago Sativa Defensin 1 (MsDef1), A Natural Tumor Targeted Sensitizer for Improving Chemotherapy: Translation from Anti-Fungal Agent to Potential Anti-Cancer Agent

Pandurangi, R. S.; Shah, D.; Karwa, A.; Sagaram, U. S.

10.1101/2021.02.13.431112 — cancer biology — Posted on 2021-02-14

2184 Metabolomics, Transcriptomics and Functional Glycomics Reveals Bladder Cancer Cells Plasticity and Enhanced Aggressiveness Facing Hypoxia and Glucose Deprivation

Peixoto, A.; Freitas, R. A.; Ferreira, D. A.; Relvas-Santos, M.; Paulo, P.; Cardoso, M.; Soares, J.; Gaiteiro, C. A.; Palmeira, C.; Teixeira, F.; Ferreira, R.; Oliveira, M. J.; Silva, A.; Santos, L. L.; Ferreira, J. A.

10.1101/2021.02.14.431133 — cancer biology — Posted on 2021-02-14

2185 Clinically Validated Model Predicts the Effect of Intratumoral Heterogeneity on Overall Survival for Non-Small Cell Lung Cancer (NSCLC) Patients

Ghaderi, N.; Jung, J. H.; Odde, D. J.; Peacock, J.

10.1101/2021.02.13.431080 — cancer biology — Posted on 2021-02-14

2186 Cancer phylogenetics using single-cell RNA-seq data

Moravec, J. C.; Lanfear, R.; Spector, D.; Diermeier, S.; Gavryushkin, A.

10.1101/2021.01.07.425804 — cancer biology — Posted on 2021-02-14

2187 Synthesis, Physiochemical and Biological evaluation of Inclusion Complex of Benzyl Isothiocyanate encapsulated in cyclodextrins for triple negative breast cancer

Uppal, S.; Kumar, R.; Kaur, K.; Sareen, S.; Bhatia, A.; Mehta, S. K.

10.1101/2021.02.14.430873 — cancer biology — Posted on 2021-02-15

2188 BET Inhibition Enhances TNF Mediated Anti-Tumor Immunity

Wellinger, L. C.; Hogg, S. J.; Newman, D. M.; Friess, T.; Geiss, D.; Michie, J.; Ramsbottom, K. M.; Bacac, M.; Fauti, T.; Marbach, D.; Jarassier, L.; Thienger, P.; Paehler, A.; Cluse, L. A.; Kearney, C. J.; Vervoort, S. J.; Oliaro, J.; Shortt, J.; Ruefli-Brasse, A.; Rohle, D.; Johnstone, R. W.

10.1101/2021.02.15.429851 — cancer biology — Posted on 2021-02-15

2189 Tumor expressed CD95 causes suppression of anti-tumor activity of NK cells in a model of triple negative breast cancer

Qadir, A. S.; Guegan, J. P.; Ginestier, C.; Chaibi, A.; Bessede, A.; Charafe-Jauffret, E.; Macario, M.; Lavoue, V.; de la Motte Rouge, T.; Law, C.; Vilker, J.; Wang, H.; Stroup, E.; Schipma, M. J.; Bridgeman, B.; Murmann, A. E.; Ji, Z.; Legembre, P.; Peter, M. E.

10.1101/2021.02.12.431011 — cancer biology — Posted on 2021-02-15

2190 DARPP-32 promotes ERBB3-mediated resistance to molecular targeted therapy in EGFR-mutated lung adenocarcinoma

Alam, S. K.; Zhang, Y.; Wang, L.; Zhu, Z.; Hernandez, C. E.; Zhou, Y.; Yang, N.; Lei, J.; Chen, X.; Zeng, L.; Klein, M. A.; Hoeppner, L. H.

10.1101/2021.02.12.430856 — cancer biology — Posted on 2021-02-15

2191 A Brownian ratchet model for DNA loop extrusion by the cohesin complex

Higashi, T. L.; Tang, M.; Pobegalov, G.; Uhlmann, F.; Molodtsov, M.

10.1101/2021.02.14.431132 — biophysics — Posted on 2021-02-14

2192 Structural origins of protein conformational entropy

Caro, J. A.; Valentine, K. G.; Wand, J.

10.1101/2021.02.12.430981 — biophysics — Posted on 2021-02-14

2193 Effect of cellular rearrangement time delays on the rheology of vertex models for confluent tissues

Erdemci-Tandogan, G.; Manning, M. L.

10.1101/2021.02.13.431087 — biophysics — Posted on 2021-02-14

2194 MEMS enabled miniaturized light-sheet microscopy with all optical control

Bakas, S.; Uttamchandani, D.; Toshiyoshi, H.; Bauer, R.

10.1101/2021.02.13.431066 — biophysics — Posted on 2021-02-14

2195 Inactivation of Aβ42 Protomer-dimer Dissociation Reaction via Increasing Protomer Size

Kurisaki, I.; Tanaka, S.

10.1101/2021.02.12.431048 — biophysics — Posted on 2021-02-14

2196 Close to optimal cell sensing ensures the robustness of tissue differentiation process: the avian photoreceptor mosaic case

Barua, A.; Beygi, A.; Hatzikirou, H.

10.1101/2021.02.14.431147 — biophysics — Posted on 2021-02-14

2197 The Kinetic Landscape of Nucleosome Assembly: A Coarse-Grained Molecular Dynamics Study

Brandani, G. B.; Tan, C.; Takada, S.

10.1101/2021.02.14.431121 — biophysics — Posted on 2021-02-14

2198 Structural and thermodynamic analyses of human TMED1 (p24γ1) Golgi dynamics

Mota, D. C. A. M.; Mori, R. M.; Batista, M. R. B.; Basso, L. G. M.; Cardoso, I. A.; Nonato, M. C.; Costa-Filho, A. J.; Mendes, L. F. S.

10.1101/2021.02.13.431076 — biophysics — Posted on 2021-02-14

2199 A Multiscale Model for Quantitative Prediction of Insulin Aggregation Nucleation Kinetics

Mishra, R. P.; Goel, G.

10.1101/2021.02.13.431119 — biophysics — Posted on 2021-02-14

2200 Cell-extracellular matrix interactions in the fluidic phase direct the topology and polarity of self-organized epithelial structures

Ouyang, M.; Yu, J.-Y.; Chen, Y.; Deng, L.; Guo, C.-L.

10.1101/2020.05.12.090068 — biophysics — Posted on 2021-02-14

2201 Tyrosine 121 moves revealing a druggable pocket that couples catalysis to ATP-binding in serine racemase

Koulouris, C. R.; Gardiner, S. E.; Harris, T. K.; Elvers, K. T.; Roe, S. M.; Gillespie, J. A.; Ward, S. E.; Grubisha, O.; Nicholls, R. A.; Atack, J. R.; Bax, B. D.

10.1101/2021.02.12.430960 — biophysics — Posted on 2021-02-15

2202 Experimental Control of a Reaction Occurring during the Interaction between Chicken Anemia Virus (CAV) and Its Corresponding Antibodies

Ivanov, O.; Todorov, P.; Simeonov, K.; Vaseashta, A.

10.1101/2021.02.12.430950 — biophysics — Posted on 2021-02-15

2203 Mutation N501Y in RBD of Spike Protein Strengthens the Interaction between COVID-19 and its Receptor ACE2

Tian, F.; Tong, B.; Sun, L.; Shi, S.; Zheng, B.; Wang, Z.; Dong, X.; Zheng, P.

10.1101/2021.02.14.431117 — biophysics — Posted on 2021-02-15

2204 Expanding N-Glycopeptide Identifications by Fragmentation Prediction and Glycome Network Smoothing

Klein, J. A.; Zaia, J. A.; Carvalho, L.

10.1101/2021.02.14.431154 — bioinformatics — Posted on 2021-02-14

2205 Sparcle: assigning transcripts to cells in multiplexed images

Prabhakaran, S.; Nawy, T.; Pe'er, D.

10.1101/2021.02.13.431099 — bioinformatics — Posted on 2021-02-14

2206 Overexpression of ELOVL6 has been associated with poor prognosis in patients with head and neck squamous cell carcinoma

wang, r.

10.1101/2021.02.13.431065 — bioinformatics — Posted on 2021-02-14

2207 PDBrenum: a webserver and program providing Protein Data Bank files renumbered according to their UniProt sequences

Faezov, B.; Dunbrack, R.

10.1101/2021.02.14.431128 — bioinformatics — Posted on 2021-02-14

2208 VisVariant: A java program to visualise genetic variants in next-generation sequencing data

Lau, K. W.; Kleeman, M.; Reuter, C.; Lorincz, A. T.

10.1101/2021.02.12.431037 — bioinformatics — Posted on 2021-02-14

2209 Domain adaptive neural networks improvecross-species prediction of transcription factor binding

Cochran, K.; Srivastava, D.; Shrikumar, A.; Balsubramani, A.; Kundaje, A.; Mahony, S.

10.1101/2021.02.13.431115 — bioinformatics — Posted on 2021-02-14

2210 APPLES-2: Faster and More Accurate Distance-based Phylogenetic Placement using Divide and Conquer

Balaban, M.; Roush, D.; Zhu, Q.; Mirarab, S.

10.1101/2021.02.14.431150 — bioinformatics — Posted on 2021-02-14

2211 Protein yield is tunable by synonymous codon changes of translation initiation sites

Bhandari, B. K.; Lim, C. S.; Remus, D. M.; Chen, A.; van Dolleweerd, C.; Gardner, P. P.

10.1101/726752 — bioinformatics — Posted on 2021-02-14

2212 Comprehensive generation, visualization, and reporting of quality control metrics for single-cell RNA sequencing data

Hong, R.; Koga, Y.; Bandyadka, S.; Leshchyk, A.; Wang, Z.; Alabdullatif, S.; Wang, Y.; Akavoor, V.; Cao, X.; Sarfraz, I.; Jansen, F.; Johnson, W. E.; Yajima, M.; Campbell, J. D.

10.1101/2020.11.16.385328 — bioinformatics — Posted on 2021-02-14

2213 RatsPub: a webservice aided by deep learning to mine PubMed for addiction-related genes

Gunturkun, M. H.; Flashner, E.; Wang, T.; Mulligan, M. K.; Williams, R. W.; Prins, P.; Chen, H.

10.1101/2020.09.17.297358 — bioinformatics — Posted on 2021-02-14

2214 A computational approach to identify possible symbiotic mechanisms between Klebsiella and the Mediterranean fly (Ceratitis capitata)

Franco, L. A.; Bravo Pariente, C. A.

10.1101/2021.02.13.431071 — bioinformatics — Posted on 2021-02-14

2215 SearcHPV: a novel approach to identify and assemble human papillomavirus-host genomic integration events in cancer

Pinatti, L. M.; Gu, W.; Wang, Y.; El Hossiny, A.; Bhangale, A. D.; Brummel, C. V.; Carey, T. E.; Mills, R. E.; Brenner, J. C.

10.1101/2021.02.11.430847 — bioinformatics — Posted on 2021-02-15

2216 HaVoC, a bioinformatic pipeline for reference-based consensus assembly and lineage assignment for SARS-CoV-2 sequences

Nguyen, P. T.; Plyusnin, I.; Sironen, T.; Vapalahti, O.; Kant, R.; Smura, T.

10.1101/2021.02.12.431018 — bioinformatics — Posted on 2021-02-15

2217 A fully automated approach for quality control of cancer mutations in the era of high-resolution whole genome sequencing

Househam, J.; Cross, W. C.; Caravagna, G.

10.1101/2021.02.13.429885 — bioinformatics — Posted on 2021-02-15

2218 Streamlining differential exon and 3 UTR usage with diffUTR

Gerber, S.; Schratt, G.; Germain, P.-L.

10.1101/2021.02.12.430963 — bioinformatics — Posted on 2021-02-15

2219 Mutations in bdcA and valS correlate with quinolone resistance in wastewater Escherichia Coli

Malekian, N.; Al-Fatlawi, A.; Berendonk, T. U.; Schroeder, M.

10.1101/2021.02.12.430739 — bioinformatics — Posted on 2021-02-15

2220 SARS-CoV-2 lineage B.1.526 emerging in the New York region detected by software utility created to query the spike mutational landscape

West, A. P.; Barnes, C. O.; Yang, Z.; Bjorkman, P. J.

10.1101/2021.02.14.431043 — bioinformatics — Posted on 2021-02-15

2221 ParticleChromo3D: A Particle Swarm Optimization Algorithm for Chromosome and Genome 3D Structure Prediction from Hi-C Data

Vadnais, D.; Middleton, M.; Oluwadare, O.

10.1101/2021.02.11.430871 — bioinformatics — Posted on 2021-02-15

2222 Computational Simulation of 4-D Micro-Circular Network in Zebrafish Tail Amputation and Regeneration

Roustaei, M.; Baek, K. I.; Wang, Z.; Cavallero, S.; Satta, S.; Lai, A.; O'Donnell, R.; Vedula, V.; Ding, Y.; Marsden, A. L.; Hsiai, T.

10.1101/2021.02.10.430654 — bioengineering — Posted on 2021-02-14

2223 Hydrogels Containing Gradients in Vascular Density Reveal Dose-Dependent Role of Angiocrine Cues on Stem Cell Behavior

Ngo, M. T.; Barnhouse, V. R.; Gilchrist, A. E.; Hunter, C. J.; Hensold, J. N.; Harley, B. A. C.

10.1101/2021.02.12.431015 — bioengineering — Posted on 2021-02-14

2224 Aggregation-induced emission dots assisted non-invasive fluorescence hysterography in near-infrared IIb window

Yu, X.; Ying, Y.; Feng, Z.; Qi, J.; Zheng, J.; Zhang, Y.; Liu, J.; Qian, J.; Tang, B. Z.; Zhang, D.

10.1101/2021.02.14.431069 — bioengineering — Posted on 2021-02-14

2225 Comprehensive metabolic engineering for fermenting glycerol efficiently in Saccharomyces cerevisiae

Khattab, S. M. R.; Watanabe, T.

10.1101/2021.02.13.430370 — bioengineering — Posted on 2021-02-15

2226 Mesenchymal stem cells carry and transport clusters of cancer cells

Zarubova, J.; Hasani-Sadrabadi, M. M.; Norris, S. C.; Kasko, A. M.; Li, S.

10.1101/2021.02.11.430875 — bioengineering — Posted on 2021-02-15

2227 Metabolic and Process Engineering for Microbial Production of Protocatechuate from Xylose with Corynebacterium glutamicum

Labib, M.; Görtz, J.; Brüsseler, C.; Kallscheuer, N.; Gätgens, J.; Jupke, A.; Marienhagen, J.; Noack, S.

10.1101/2021.02.12.430943 — bioengineering — Posted on 2021-02-15

2228 Nano-hydroxyapatite coating synthesized on quasi-fibrillar superstructures of collagen hydrolysate leads to superior osteoblast proliferation when compared to nano-hydroxyapatite synthesized on collagen fibrils

Banerjee, P.; Bajaj, M.; Bhat, C.; Y, G.; Irle, H.

10.1101/2021.02.13.431097 — biochemistry — Posted on 2021-02-14

2229 SUMOylation of the chromodomain factor MRG-1 in C. elegans affects chromatin-regulatory dynamics

Baytek, G.; Blume, A.; Gerceker Demirel, F.; Bulut, S.; Mertins, P.; Tursun, B.

10.1101/2021.02.14.431134 — biochemistry — Posted on 2021-02-14

2230 Thiophosphopeptides Instantly Targeting Golgi Apparatus and Selectively Killing Cancer Cells

Tan, W.; Zhang, Q.; Wang, J.; Yi, M.; He, H.; Xu, B.

10.1101/2021.02.13.431079 — biochemistry — Posted on 2021-02-14

2231 Structure and mechanistic analyses of the gating mechanism of elongating ketosynthases

Mindrebo, J. T.; Chen, A.; Kim, W. E.; Re, R. N.; Davis, T. D.; Noel, J. P.; Burkart, M. D.

10.1101/2021.02.13.431092 — biochemistry — Posted on 2021-02-14

2232 Structural basis of meiotic chromosome synaptic elongation through hierarchical fibrous assembly of SYCE2-TEX12

Dunce, J. M.; Salmon, L. J.; Davies, O. R.

10.1101/2020.12.30.424799 — biochemistry — Posted on 2021-02-14

2233 Paip2 associates with PABPC1 on mRNA, and may facilitate PABPC1 dissociation from mRNA upon deadenylation

Xie, J.; Wei, X.; Kozlov, G.; Chen, Y.; Menade, M.

10.1101/2021.02.07.430161 — biochemistry — Posted on 2021-02-14

2234 Poly(A) binding protein is required for mRNP remodeling to form P-bodies in mammalian cells

Xie, J.; Chen, Y.; Wei, X.; Kozlov, G.

10.1101/2021.02.07.430159 — biochemistry — Posted on 2021-02-14

2235 Structure of an infectious mammalian prion

Kraus, A.; Hoyt, F.; Schwartz, C.; Hansen, B.; Hughson, A. G.; Artikis, E.; Race, B.; Caughey, B.

10.1101/2021.02.14.431014 — biochemistry — Posted on 2021-02-15

2236 Cancer blues? A validated judgment bias task suggests pessimism in nude mice with tumors

Resasco, A.; MacLellan, A.; Ayala, M. A.; Kitchenham, L.; Edwards, M.; Lam, S.; Dejardin, S.; Mason, G.

10.1101/2021.02.13.431089 — animal behavior and cognition — Posted on 2021-02-14

2237 Female and male Sirex noctilio use age and size to select a mate

Queffelec, J.; Allison, J. D.; Slippers, B.; Greeff, J. M.

10.1101/2021.02.14.431120 — animal behavior and cognition — Posted on 2021-02-14

2238 Genomic evidence that governmentally produced Cannabis sativa poorly represents genetic variation available in state markets

Vergara, D.; Huscher, E. L.; Keepers, K. G.; Pisupati, R.; Schwabe, A. L.; McGlaughlin, M. E.; Kane, N. C.

10.1101/2021.02.13.431041 — genomics — Posted on 2021-02-14

2239 Constructing Local Cell Sepcific Networks from Single Cell Data

Wang, X.; Choi, D.; Roeder, K.

10.1101/2021.02.13.431104 — genomics — Posted on 2021-02-14

2240 A benchmarking of human mitochondrial DNA haplogroup classifiers from whole-genome and whole-exome sequence data

Garcia-Olivares, V.; Munoz-Barrera, A.; Lorenzo-Salazar, J. M.; Zaragoza-Trello, C.; Rubio-Rodriguez, L. A.; Diaz-de Usera, A.; Jaspez-Toledo, D.; Inigo-Campos, A.; Gonzalez-Montelongo, R.; Flores, C.

10.1101/2021.02.11.430775 — genomics — Posted on 2021-02-15

2241 Epigenetic modulation in the pathogenesis and treatment of inherited aortic aneurysm conditions

Kang, B. E.; Bagirzadeh, R.; Bedja, D.; Doyle, J. J.; MacFarlane, E. G.; Dietz, H. C.

10.1101/2021.02.12.431010 — genetics — Posted on 2021-02-14

2242 Shrinkage Parameter Estimation in Penalized Logistic RegressionAnalysis of Case-Control Data

Yu, Y.; Chen, S.; McNeney, B.

10.1101/2021.02.12.430986 — genetics — Posted on 2021-02-14

2243 Antisense oligonucleotide-based drug development for Cystic Fibrosis patients carrying the 3849+10kb C-to-T splicing mutation

Oren, Y. S.; Irony-Tur Sinai, M.; Golec, A.; Barchad-Avitzur, O.; Mutyam, V.; Li, Y.; Hong, J.; Ozeri-Galai, E.; Hatton, A.; Reiter, J.; Sorscher, E. J.; Wilton, S. D.; Kerem, E.; Rowe, S. M.; Sermet-Gaudelus, I.; Kerem, B.

10.1101/2021.02.14.431123 — genetics — Posted on 2021-02-14

2244 Exon 9 LEPR Gene SNP Polymorphism of Hybrid Chickens F2 Kambro Crossbreeds of female F1 Kambro with male F1 Kambro

Mahardhika, I. W. S.; Daryono, B. S.

10.1101/2021.02.13.431072 — genetics — Posted on 2021-02-14

2245 Evaluating Sleep Disturbances in Children with Rare Genetic Neurodevelopmental Syndromes

Veatch, O. J.; Malow, B. A.; Lee, H.-S.; Knight, A.; Barrish, J. O.; Neul, J. L.; Lane, J. B.; Skinner, S. A.; Kaufmann, W. E.; Miller, J. L.; Driscoll, D. J.; Bird, L. M.; Butler, M. G.; Dykens, E. M.; Gold, J.-A.; Kimonis, V.; Bacino, C. A.; Tan, W.-H.; Kothare, S. V.; Peters, S. U.; Percy, A. K.; Glaze, D. G.

10.1101/2021.02.12.430633 — genetics — Posted on 2021-02-15

2246 Delineating the molecular and phenotypic spectrum of the SETD1B-related syndrome

Weerts, M. J. A.; Lanko, K.; Guzman-Vega, F. J.; Jackson, A.; Ramakrishnan, R.; Cardona-Londono, K. J.; Pena-Guerra, K. A.; van Bever, Y.; van Paassen, B.; Kievit, A.; van Slegtenhorst, M.; Allen, N. M.; Kehoe, C. M.; Robinson, H. K.; Pang, L.; Banu, S. H.; Zaman, M.; Efthymiou, S.; Houlden, H.; Jarvela, I.; Lauronen, L.; Maatta, T.; Schrauwen, I.; Leal, S. M.; Ruivenkamp, C. A. L.; Barge-Schaapveld, D. Q. C. M.; Peeters-Scholte, C. M. P. C. D.; Galehdari, H.; Mazaheri, N.; Sisodiya, S. M.; Harrison, V.; Sun, A.; Thies, J.; Pedroza, L. A.; Taranchenko, Y. L.; Chinn, I. K.; Lupski, J. R.; Garza

10.1101/2021.02.11.430742 — genetics — Posted on 2021-02-15

2247 Rapid evolution of complete dosage compensation in Poecilia

Metzger, D. C.; Sandkam, B. A.; Darolti, I.; Mank, J. E.

10.1101/2021.02.12.431036 — evolutionary biology — Posted on 2021-02-14

2248 How plants minimize somatic evolution

Kiss, M.; Szöllosi, G. J.; Derenyi, I.

10.1101/2021.02.13.431063 — evolutionary biology — Posted on 2021-02-14

2249 Phylogenomic subsampling and the search for phylogenetically reliable loci

Mongiardino Koch, N.

10.1101/2021.02.13.431075 — evolutionary biology — Posted on 2021-02-14

2250 On the evolution of host specificity: a case study of helminths

Pfenning-Butterworth, A. C.; Botero-Canola, S.; Cressler, C.

10.1101/2021.02.13.431093 — evolutionary biology — Posted on 2021-02-14

2251 The essential role of Dnmt1 in gametogenesis in the large milkweed bug Oncopeltus fasciatus

Washington, J. T.; Cavender, K. R.; Amukamara, A. U.; McKinney, E. C.; Schmitz, R. J.; Moore, P. J.

10.1101/2020.07.23.218180 — evolutionary biology — Posted on 2021-02-15

2252 Climate warming changes synchrony of plants and pollinators

Freimuth, J.; Bossdorf, O.; Scheepens, J. F.; Willems, F. M.

10.1101/2021.01.10.425984 — ecology — Posted on 2021-02-14

2253 Forest loss in Indonesian New Guinea: trends, drivers, and outlook

Gaveau, D.; Santos, L.; Locatelli, B.; Salim, M. A.; Husnayaen, H.; Meijaard, E.; Heatubun, C.; Sheil, D.

10.1101/2021.02.13.431006 — ecology — Posted on 2021-02-14

2254 Tree phylogenetic diversity supports nature's contributions to people, but is at risk from human population growth

Davies, J.; Maurin, O.; Yessoufou, K.; Daru, B.; Bezeng, B.; Schaefer, H.; Thuiller, W.; van der Bank, M.

10.1101/2021.02.13.430985 — ecology — Posted on 2021-02-14

2255 Influence of warming temperatures on coregonine embryogenesis within and among species

Stewart, T. R.; Makinen, M.; Goulon, C.; Guillard, J.; Marjomaki, T. J.; Lasne, E.; Karjalainen, J.; Stockwell, J. D.

10.1101/2021.02.13.431107 — ecology — Posted on 2021-02-14

2256 Quantifying habitat and landscape effects on composition and structure of plant-pollinator networks in the US Northern Great Plains

Vilella-Arnizaut, I. B.; Nottebrock, H.; Fenster, C. B.

10.1101/2021.02.12.431025 — ecology — Posted on 2021-02-14

2257 A macroecological description of alternative stable states reproduces intra- and inter-host variability of gut microbiome

Zaoli, S.; Grilli, J.

10.1101/2021.02.12.430897 — ecology — Posted on 2021-02-15

2258 Competition in depleting resource environments shapes the thermal response of mosquito population fitness

Huxley, P. J.; Murray, K. A.; Cator, L. J.; Pawar, S.

10.1101/2021.02.12.430918 — ecology — Posted on 2021-02-15

2259 Animal soundscapes reveal key markers of Amazon forest degradation from fire and logging

Rappaport, D. I.; Swain, A.; Fagan, W. F.; Dubayah, R.; Morton, D. C.

10.1101/2021.02.11.430853 — ecology — Posted on 2021-02-15

2260 Nitrate enhances anaerobic oxidation of methane in boreal lake sediments

Rissanen, A. J.; Jilbert, T.; Simojoki, A.; Mangayil, R.; Aalto, S. L.; Peura, S.; Jäntti, H.

10.1101/2021.02.12.426818 — ecology — Posted on 2021-02-15

2261 Paths and Pathways that Generate Cell-Type Heterogeneity and Developmental Progression in Hematopoiesis

Girard, J. R.; Goins, L. M.; Vuu, D. M.; Sharpley, M. S.; Spratford, C. M.; Mantri, S. R.; Banerjee, U.

10.1101/2021.02.11.430681 — developmental biology — Posted on 2021-02-13

2262 p53 pro-apoptotic activity is regulated by the G2/M promoting factor Cdk1 in response to DNA damage

Ruiz-Losada, M.; Gonzalez, R.; Peropadre, A.; Baonza, A.; Estella, C.

10.1101/2021.02.13.431094 — developmental biology — Posted on 2021-02-14

2263 An exon junction complex-independent function of Barentsz in neuromuscular synapse growth

Ho, C. H.; Roignant, J.-Y.; Tang, Z.; Brown, S.; Treisman, J. E.

10.1101/2021.02.13.430688 — developmental biology — Posted on 2021-02-15

2264 Developmental co-emergence of cardiac and gut tissues modeled by human iPSC-derived organoids

Silva, A. C.; Matthys, O. B.; Joy, D. A.; Kauss, M. A.; Natarajan, V.; Lai, M. H.; Turaga, D.; Blair, A. P.; Alexanian, M.; Bruneau, B. G.; McDevitt, T. C.

10.1101/2020.04.30.071472 — developmental biology — Posted on 2021-02-15

2265 GRK2/3/5/6 knockout: The impact of individual GRKs on arrestin-binding and GPCR regulation

Drube, J.; Haider, R. S.; Matthees, E. S. F.; Reichel, M.; Zeiner, J.; Fritzwanker, S.; Ziegler, C.; Barz, S.; Klement, L.; Kliewer, A.; Miess, E.; Kostenis, E.; Schulz, S.; Hoffmann, C.

10.1101/2021.02.12.430971 — cell biology — Posted on 2021-02-13

2266 Atg8 licenses adipokine nuclear exit

Poling, M. E.; Sullivan, C. E.; Brent, A. E.; Hafer, T. L.; Rajan, A.

10.1101/2021.01.29.428913 — cell biology — Posted on 2021-02-13

2267 Ferulic acid combined with skeletal stem cells to repair irradiated bone defect

Liang, W. J.; Li, L. P.; Wang, Q.; Liao, S.; Hu, w.; Zhao, D. Z.; Li, L. Z.; Yin, F. B.; Mao, N.; Ding, L.; Zhu, H.

10.1101/2021.02.14.431131 — cell biology — Posted on 2021-02-14

2268 Multisite phosphorylation by Cdk1 initiates delayed negative feedback to control mitotic transcription

Asfaha, J.; Ord, M.; Loog, M.; Morgan, D. O.

10.1101/2021.02.14.431158 — cell biology — Posted on 2021-02-14

2269 New multiscale characterisation methodology for effective determination of isolationstructure-function relationship of extracellular vesicles.

Phan, T. H.; Divakarla, K. S.; Yeo, J. H.; Lei, Q.; Tharkar, P.; Pansani, T. N.; Leslie, K. G.; Tong, M.; Coleman, V. A.; Jamting, A.; Plessis, M.-D. D.; New, E. J.; KALIONIS, B.; Demokritou, P.; Woo, H.-K.; Cho, Y.-K.; Chrzanowski, W.

10.1101/2021.02.09.430523 — cell biology — Posted on 2021-02-14

2270 Remodeling and activation mechanisms of outer arm dyneins revealed by cryo-electron microscopy

Kubo, S.; Yang, S. K.; Black, C.; Dai, D.; Valente, M.; Gaertig, J.; Ichikawa, M.; Bui, K. H.

10.1101/2020.11.30.404319 — cell biology — Posted on 2021-02-14

2271 Ectosome uptake by glia sculpts Caenorhabditis elegans cilia

Razzauti, A.; Laurent, P.

10.1101/2021.02.14.430969 — cell biology — Posted on 2021-02-15

2272 Dynamin-2 controls complement receptor 3- mediated phagocytosis completion and closure

Mularski, A.; Wimmer, R.; Arbaretaz, F.; Le Goff, G.; Niedergang, F.

10.1101/2021.02.14.431164 — cell biology — Posted on 2021-02-15

2273 A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes corpus luteum regression

Li, D.; Chen, J.; Guo, J.; Li, L.; Cai, G.; Chen, S.; Huang, J.; Yang, H.; Zhuang, Y.; Wang, F.; Wang, X.

10.1101/2021.02.14.431152 — cell biology — Posted on 2021-02-15

2274 Reaction of ependymal cells to spinal cord injury: a potential role for oncostatin pathway and microglial cells

Chevreau, R.; Ghazale, H.; Ripoll, C.; Chalfouh, C.; Delarue, Q.; Hemonnot, A. L.; Hirbec, H.; Wahane, S.; Perrin, F.; Noristani, H.; Guerout, N.; Hugnot, J.

10.1101/2021.02.12.428106 — cell biology — Posted on 2021-02-15

2275 Programmed ER fragmentation drives selective ER inheritance and degradation in budding yeast meiosis

Otto, G. M.; Cheunkarndee, T.; Leslie, J. M.; Brar, G. A.

10.1101/2021.02.12.430990 — cell biology — Posted on 2021-02-15

2276 Reaction of ependymal cells to spinal cord injury: a potential role for oncostatin pathway and microglial cells

Chevreau, R.; Ghazale, H.; Ripoll, C.; Chalfouh, C.; Delarue, Q.; Hemonnot-Girard, A. L.; Hirbec, H.; Wahane, S.; Perrin, F.; Noristani, H.; Guerout, N.; Hugnot, J.

10.1101/2021.02.12.428106 — cell biology — Posted on 2021-02-15

2277 Melanoma cells adopt features of both mesenchymal and amoeboid migration within confining channels

Gabbireddy, S. R.; Chung, A. J.; Logue, J. S.

10.1101/2021.02.12.431031 — cell biology — Posted on 2021-02-15

2278 Newly developed ad hoc molecular assays shows how eDNA can witness and anticipate the monk seal recolonization of central Mediterranean

Valsecchi, E.; Coppola, E.; Pires, R.; Parmegiani, A.; Casiraghi, M.; Galli, P.; Bruno, A.

10.1101/2021.02.13.431078 — molecular biology — Posted on 2021-02-14

2279 CSF metabolites associate with CSF tau and improve prediction of Alzheimer's disease status

Dong, R.; Darst, B. F.; Deming, Y.; Ma, Y.; Lu, Q.; Zetterberg, H.; Blennow, K.; Carlsson, C. M.; Johnson, S. C.; Asthana, S.; Engelman, C. D.

10.1101/2021.01.31.429054 — molecular biology — Posted on 2021-02-14

2280 Molecular mechanism of the pH-dependent calcium affinity in langerin

Joswig, J.-O.; Anders, J.; Zhang, H.; Rademacher, C.; Keller, B. G.

10.1101/2020.03.11.986851 — molecular biology — Posted on 2021-02-15

2281 CRISPR/Cas9 targeting of MCPyV T antigen in Merkel tumors

Arora, R.; Gupta, K.; Vijaykumar, A.

10.1101/2021.02.14.431142 — molecular biology — Posted on 2021-02-15

2282 Easy multiple sequential CRISPR/Cas9 knockouts in cell lines using a Cre/LoxP re-cyclable vector

Dong, L.; Etemadi, N.; Vaux, D. L.

10.1101/2021.02.12.431046 — molecular biology — Posted on 2021-02-15

2283 A bacteriophage cocktail significantly reduces Listeria monocytogenes without deleterious impact on the commensal gut microbiota under simulated gastro-intestinal conditions

Jakobsen, R. R.; Trinh, J.; Bomholtz, L.; Brok-Lauridsen, S. K.; Sulakvelidze, A.; Nielsen, D. S.

10.1101/2021.02.12.431056 — microbiology — Posted on 2021-02-13

2284 A nadA mutation confers nicotinic acid auxotrophy in pro-carcinogenic intestinal Escherichia coli NC101

Lopez, L. R.; Barlogio, C. J.; Broberg, C. A.; Wang, J.; Arthur, J. C.

10.1101/2021.02.12.431052 — microbiology — Posted on 2021-02-13

2285 Suppression of Plasmodium MIF-CD74 Signaling Protects Against Severe Malaria

Baeza Garcia, A.; Siu, E.; Du, X.; Leng, L.; Franke-Fayard, B.; Janse, C. J.; Howland, S.; Renia, L.; Lolis, E.; Bucala, R.

10.1101/2021.02.14.430970 — microbiology — Posted on 2021-02-14

2286 Genomes of gut bacteria from Nasonia wasps shed light on phylosymbiosis and microbe-assisted hybrid breakdown

Cross, K. L.; Leigh, B. A.; Hatmaker, E. A.; Mikaelyan, A.; Miller, A. K.; Bordenstein, S. R.

10.1101/2021.02.13.431100 — microbiology — Posted on 2021-02-14

2287 Chemical ecology of a tripartite symbiosis

Mucci, N. C.; Jones, K. A.; Cao, M.; Wyatt, M. R.; Foye, S.; Kauffman, S.; Taufer, M.; Chikaraishi, Y.; Steffan, S.; Campagna, S.; Goodrich-Blair, H.

10.1101/2021.02.13.430781 — microbiology — Posted on 2021-02-14

2288 Chemical ecology of a tripartite symbiosis

Mucci, N. C.; Jones, K. A.; Cao, M.; Wyatt, M. R.; Foye, S.; Kauffman, S.; Taufer, M.; Chikaraishi, Y.; Steffan, S.; Campagna, S.; Goodrich-Blair, H.

10.1101/2021.02.13.430781 — microbiology — Posted on 2021-02-15

2289 In vivo generation of BK and JC polyomavirus defective viral genomes in human urine samples associated with higher viral loads

Addetia, A.; Phung, Q.; Bradley, B. T.; Lin, M.; Zhu, H.; Xie, H.; Huang, M.-L.; Greninger, A. L.

10.1101/2021.02.12.431053 — microbiology — Posted on 2021-02-15

2290 Fast, efficient and virus-free generation of TRAC-replaced CAR T cells

Kath, J.; Du, W.; Thommandru, B.; Turk, R.; Amini, L.; Stein, M.; Zittel, T.; Martini, S.; Ostendorf, L.; Wilhelm, A.; Akyuez, L.; Rehm, A.; Hoepken, U. E.; Pruss, A.; Kuenkele, A.; Jacobi, A. M.; Volk, H.-D.; Schmueck-Henneresse, M.; Reinke, P.; Wagner, D. L.

10.1101/2021.02.14.431017 — immunology — Posted on 2021-02-14

2291 Meta-analysis of scRNA seq data to define the landscape of human liver immune homeostasis.

Rocque, B. L.; Barbetta, A.; Singh, P.; Goldbeck, C.; Helou, D. G.; Loh, Y.-H. E.; Ung, N.; Lee, J.; Akbari, O.; Emamaullee, J.

10.1101/2021.02.12.430976 — immunology — Posted on 2021-02-14

2292 A single-cell atlas of lymphocyte adaptive immune repertoires and transcriptomes reveals age-related differences in convalescent COVID-19 patients

Bieberich, F.; Vazquez-Lombardi, R.; Yermanos, A.; Ehling, R. A.; Mason, D. M.; Wagner, B.; Kapetanovic, E.; Di Roberto, R. B.; Weber, C. R.; Savic, M.; Rudolf, F.; Reddy, S. T.

10.1101/2021.02.12.430907 — immunology — Posted on 2021-02-15

2293 Negative correlation between average speed and average turning angle naturally arises for sparsely sampled cell movement data

Ganusov, V. V.; Zenkov, V. S.; Majumder, B.

10.1101/2020.12.30.424897 — immunology — Posted on 2021-02-15

2294 Innate Immune sensing of Influenza A viral RNA through IFI16 promotes pyroptotic cell death

Mishra, S.; Raj, A. S.; Kumar, A.; Rajeevan, A.; Kumari, P.; Kumar, H.

10.1101/2021.02.13.431067 — immunology — Posted on 2021-02-15

2295 Cholinergic signalling at the body wall neuromuscular junction couples to distal inhibition of feeding in C. elegans

Izquierdo, P. G.; Thisainathan, T.; Atkins, J. H.; Lewis, C. J.; Tattersall, J. E. H.; Green, A. C.; Holden-Dye, L.; OConnor, V.

10.1101/2021.02.12.430967 — neuroscience — Posted on 2021-02-15

2296 SIPA1L1/SPAR1 is a non-PSD protein involved in GPCR signaling

Matsuura, K.; Kobayashi, S.; Konno, K.; Yamasaki, M.; Horiuchi, T.; Senda, T.; Hayashi, T.; Satoh, K.; Arima-Yoshida, F.; Iwasaki, K.; Negishi, L.; Yasui-Shimizu, N.; Kohu, K.; Kawahara, S.; Kirino, Y.; Nakamura, T.; Watanabe, M.; Yamamoto, T.; Manabe, T.; Akiyama, T.

10.1101/2021.02.12.430872 — neuroscience — Posted on 2021-02-15

2297 Neural indicators of human gut feelings

Mayeli, A.; Al Zoubi, O.; White, E. J.; Chappelle, S.; Kuplicki, R.; Smith, R.; Feinstein, J. S.; Bodurka, J.; Paulus, M. P.; Khalsa, S. S.

10.1101/2021.02.11.430867 — neuroscience — Posted on 2021-02-15

2298 During natural viewing, neural processing of visual targets continues throughout saccades

Stankov, A. D.; Touryan, J.; Gordon, S.; Ries, A. J.; Ki, J.; Parra, L. C.

10.1101/2021.02.11.430486 — neuroscience — Posted on 2021-02-15

2299 Tracing Human Amygdala across School Age

Zhou, Q.; Liu, S.; Jiang, C.; He, Y.; Zuo, X.-N.

10.1101/2021.02.11.430883 — neuroscience — Posted on 2021-02-15

2300 Enduring motor memory of walking on a split-belt treadmill in young children and adults

Lissinna, B.; Smith, A.; La, K.; Yang, J. F.

10.1101/2021.02.12.430812 — neuroscience — Posted on 2021-02-15

2301 Fractal dimension of EEG signal senses complexity of fractal animations

Dorosti, S.; Khosrowabadi, R.

10.1101/2021.02.11.430870 — neuroscience — Posted on 2021-02-15

2302 Genetic influence on resting state networks in young male and female adults

Hwang, G.; Kulkarni, A. P.; Mohanty, R.; Cook, C. J.; Nair, V. A.; Bendlin, B. B.; Meyerand, E.; Prabhakaran, V.

10.1101/2021.02.13.430156 — neuroscience — Posted on 2021-02-15

2303 Modest changes in Spi1 dosage reveal the potential for altered microglial function as seen in Alzheimers disease

Jones, R. E.; Andrews, R.; Holmans, P.; Hill, M.; Taylor, P. R.

10.1101/2021.02.12.430903 — neuroscience — Posted on 2021-02-15

2304 Synergistic application of continuous granulation and selective laser sintering 3D printing for the development of pharmaceutical dosage forms with enhanced dissolution rates and physical properties

Thakkar, R.; Zhang, Y.; Zhang, J.; Maniruzzaman, M.

10.1101/2021.02.13.430988 — pharmacology and toxicology — Posted on 2021-02-14

2305 Conserved residues in the extracellular loop 2 regulate Stachel-mediated activation of ADGRG2

Gad, A. A.; Azimzadeh, P.; Balenga, N.

10.1101/2021.02.14.431159 — pharmacology and toxicology — Posted on 2021-02-14

2306 Systematic beach monitoring as a health assessment tool: cetacean morbillivirus under non-epizootic circumstances in stranded dolphins

Marutani, V. H. B.; Miyabe, F. M.; Alfieri, A. F.; Domit, C.; de Matos, A. M. R. N.; Filho, M. R. C. M.; Bracarense, A. P. F. R. L.

10.1101/2021.02.13.431109 — pathology — Posted on 2021-02-14

2307 Tooth chipping patterns in Paranthropus do not support regular hard food mastication

Towle, I.; Irish, J. D.; Fannin, L. D.; Loch, C.

10.1101/2021.02.12.431024 — paleontology — Posted on 2021-02-14

2308 Unravelling cotton RNAseq repositories to the fiber development specific modules and their alliance with the fiber-related traits

Prasad, P.; Khatoon, U.; Verma, R. K.; Kumar, A.; Mohapatra, D.; Bhattacharya, P.; Bag, S. K.; Sawant, S. V.

10.1101/2021.02.13.431059 — plant biology — Posted on 2021-02-13

2309 Whole plant-environment microscopy reveals how Bacillus subtilis utilises the soil pore space to colonise plant roots

Liu, Y.; Patko, D.; Engelhardt, I.; George, T. S.; Stanley-Wall, N.; Ladmiral, V.; Ameduri, B.; Daniell, T. J.; Holden, N.; MacDonald, M. P.; Dupuy, L. X.

10.1101/2021.02.13.430456 — plant biology — Posted on 2021-02-13

2310 slim shady is a novel allele of PHYTOCHROMEB present in the T-DNA line SALK_015201

Dash, L.; McEwan, R. E.; Montes, C.; Mejia, L.; Walley, J. W.; Dilkes, B. P.; Kelley, D. R.

10.1101/2021.02.12.430994 — plant biology — Posted on 2021-02-13

2311 Developmental effects on pattern visual evoked potentials characterized by principal component analysis

Patterson Gentile, C.; Joshi, N. R.; Ciuffreda, K.; Arbogast, K.; Master, C.; Aguirre, G.

10.1101/2020.12.11.420158 — neuroscience — Posted on 2021-02-13

2312 The neural basis of intelligence in fine-grained cortical topographies

Feilong, M.; Guntupalli, J. S.; Haxby, J. V.

10.1101/2020.06.06.138099 — neuroscience — Posted on 2021-02-13

2313 Functional and genetic determinants of mutation rate variability in regulatory elements of cancer genomes

Lee, C. A.; Abd-Rabbo, D.; Reimand, J.

10.1101/2020.07.29.226373 — genomics — Posted on 2021-02-13

2314 Selection for increased tibia length in mice alters skull shape through parallel changes in developmental mechanisms

Unger, C. M.; Devine, J.; Hallgrimsson, B.; Rolian, C.

10.1101/2020.10.01.321604 — evolutionary biology — Posted on 2021-02-13

2315 Modeling gene expression evolution with EvoGeneX uncovers differences in evolution of species, organs and sexes

Pal, S.; Oliver, B.; Przytycka, T. M.

10.1101/2020.01.06.895615 — evolutionary biology — Posted on 2021-02-13

2316 Spatial population genetics in heavily managed species: Separating patterns of historical translocation from contemporary gene flow in white-tailed deer

Chafin, T. K.; Zbinden, Z. D.; Douglas, M. R.; Martin, B. T.; Middaugh, C. R.; Gray, M. C.; Ballard, J. R.; Douglas, M. E.

10.1101/2020.09.22.308825 — evolutionary biology — Posted on 2021-02-13

2317 Evaluation of high-resolution atmospheric and oceanic simulations of the California Current System

Renault, L.; McWilliams, J. C.; Kessouri, F.; Jousse, A.; Frenzel, H.; Chen, R.; Deutsch, C. A.

10.1101/2020.02.10.942730 — ecology — Posted on 2021-02-13

2318 Biogeochemical variability in the California Current System

Deutsch, C. A.; Frenzel, H.; McWilliams, J. C.; Renault, L.; Kessouri, F.; Howard, E. M.; Liang, J.-H.; Bianchi, D.; Yang, S.

10.1101/2020.02.10.942565 — ecology — Posted on 2021-02-13

2319 A Connectivity-based Psychometric Prediction Framework for Brain-behavior Relationship Studies

Wu, J.; Eickhoff, S. B.; Hoffstaedter, F.; Patil, K. R.; Schwender, H.; Yeo, B. T. T.; Genon, S.

10.1101/2020.01.15.907642 — neuroscience — Posted on 2021-02-13

2320 A specific agonist of the orphan nuclear receptor NR2F1 suppresses metastasis through the induction of cancer cell dormancy

Khalil, B. D.; Sanchez, R.; Rahman, T.; Rodriguez-Tirado, C. A.; Moritsch, S.; Rodriguez Martinez, A.; Miles, B.; Farias, E.; Mezei, M.; Cheung, J. F.; Nobre, A. R.; Kale, N.; Sproll, K. C.; Sosa, M. S.; Aguirre-Ghiso, J. A.

10.1101/2021.01.30.428967 — cancer biology — Posted on 2021-02-13

2321 Cooperative stator assembly of bacterial flagellar motor mediated by rotation

Ito, K. I.; Nakamura, S.; Toyabe, S.

10.1101/2020.04.26.059089 — biophysics — Posted on 2021-02-13

2322 Bfimpute: A Bayesian factorization method to recover single-cell RNA sequencing data

Wen, Z.-H.; Langsam, J. L.; Zhang, L.; Shen, W.; Zhou, X.

10.1101/2021.02.10.430649 — bioinformatics — Posted on 2021-02-13

2323 The bacterial iron sensor IdeR recognizes its DNA targets by indirect readout

Marcos-Torres, F. J.; Maurer, D.; Griese, J. J.

10.1101/2021.02.12.430932 — biochemistry — Posted on 2021-02-13

2324 Pescoids and chimeras to probe early evo-devo in the fish Astyanax mexicanus

TORRES-PAZ, J.; RETAUX, S.

10.1101/2020.10.06.328500 — developmental biology — Posted on 2021-02-13

2325 Tracing production instability in a clonally-derived CHO cell line using single cell transcriptomics

Tzani, I.; Herrmann, N.; Carillo, S.; Spargo, C. A.; Hagan, R.; Barron, N.; Bones, J.; Dillmore, W. S.; Clarke, C.

10.1101/2020.11.04.368480 — cell biology — Posted on 2021-02-13

2326 A Human Multi-Lineage Hepatic Organoid Model for Liver Fibrosis

GUAN, Y.; Enejder, A.; Wang, M.; Fang, Z.; Cui, L.; Chen, S.-Y.; Wang, J.; Tan, Y.; Wu, M.; Chen, X.; Johansson, P. K.; Osman, I.; Kunimoto, K.; Russo, P.; Heilshorn, S. C.; Peltz, G.

10.1101/2020.09.01.278473 — cell biology — Posted on 2021-02-13

2327 Effective downregulation of BCR-ABL tumorigenicity by RNA targeted CRISPR-Cas13a

Singh, A.; Bhatia, P.

10.1101/840900 — molecular biology — Posted on 2021-02-13

2328 Sex-specific lipid profiles in muscle of Atlantic salmon juveniles

House, A. H.; Primmer, C. R.; Debes, P. V.; Erkinaro, J.; Kakela, R.; Kurko, J.

10.1101/2020.11.13.379321 — molecular biology — Posted on 2021-02-13

2329 Modelling the impact of the macroalgae Asparagopsis taxiformis on rumen microbial fermentation and methane production

Munoz-Tamayo, R.; Chagas, J. C.; Ramin, M.; Krizsan, S. J.

10.1101/2020.11.09.374330 — microbiology — Posted on 2021-02-13

2330 Methane-derived carbon flow through host-virus trophic networks in soil

Lee, S.; Sieradzki, E. T.; Nicolas, A. M.; Walker, R.; Firestone, M. K.; Hazard, C.; Nicol, G. W.

10.1101/2020.12.16.423115 — microbiology — Posted on 2021-02-13

2331 A non-adaptive demographic mechanism for genome expansion in Streptomyces

Choudoir, M. J.; Järvenpää, M. J.; Marttinen, P.; Buckley, D. H.

10.1101/2021.01.09.426074 — microbiology — Posted on 2021-02-13

2332 Transcriptome signature of cell viability predicts drug response and drug interaction for Tuberculosis

Srinivas, V.; Ruiz, R. A.; Pan, M.; Immanuel, S. R. C.; Peterson, E. J. R.; Baliga, N. S.

10.1101/2021.02.09.430468 — microbiology — Posted on 2021-02-13

2333 Virus transmission by ultrasonic scaler and its prevention by antiviral agent

Fidler, A.; Steyer, A.; Gaspersic, R.

10.1101/2021.02.10.430630 — microbiology — Posted on 2021-02-13

2334 Distinct function of Mediator subunits in fungal development, stress response and secondary metabolism in fungal pathogen Fusarium verticillioides

Zhou, Z.; Yan, H.; Kim, M. S.; Shim, W. B.

10.1101/2021.02.11.430821 — microbiology — Posted on 2021-02-13

2335 TCRβ Sequencing Reveals Spatial and Temporal Evolution of Clonal CD4 T cell Responses in a Breach of Tolerance Model of Inflammatory Arthritis

Al Khabouri, S.; Benson, R. A.; Prendergast, C. T.; Gray, J. I.; Otto, T. D.; Brewer, J. M.; Garside, P.

10.1101/2020.11.15.383539 — immunology — Posted on 2021-02-13

2336 Ventral Pallidum GABA Neurons Mediate Motivation Underlying Risky Choice

Farrell, M. R.; Esteban, J.; Faget, L.; Floresco, S. B.; Hnasko, T. S.; Mahler, S. V.

10.1101/2020.08.04.221960 — neuroscience — Posted on 2021-02-13

2337 Independent population coding of the past and the present in prefrontal cortex during learning

Maggi, S.; Humphries, M. D.

10.1101/668962 — neuroscience — Posted on 2021-02-13

2338 Adaptation to recent outcomes attenuates the lasting effect of initial experience on risky decisions

Kobor, A.; Kardos, Z.; Takacs, A.; Elteto, N.; Janacsek, K.; Toth-Faber, E.; Csepe, V.; Nemeth, D.

10.1101/2020.09.25.313551 — neuroscience — Posted on 2021-02-13

2339 Automated Analysis of Low-Field Brain MRI in Cerebral Malaria

Tu, D.; Goyal, M. S.; Dworkin, J. D.; Kampondeni, S.; Vidal, L.; Biondo-Savin, E.; Juvvadi, S.; Raghavan, P.; Nicholas, J.; Chetcuti, K.; Clark, K.; Satterthwaite, T. D.; Yushkevich, P.; Davatzikos, C.; Erus, G.; Postels, D. G.; Taylor, T. E.; Small, D. S.; Shinohara, R. T.

10.1101/2020.12.23.424020 — neuroscience — Posted on 2021-02-13

2340 Phenotypic analysis of catastrophic childhood epilepsy genes: The Epilepsy Zebrafish Project

Griffin, A.; Carpenter, C.; Liu, J.; Paterno, R.; Grone, B.; Hamling, K.; Moog, M.; Dinday, M. T.; Figueroa, F.; Anvar, M.; Ononuju, C.; Qu, T.; Baraban, S. C.

10.1101/2021.02.11.430844 — neuroscience — Posted on 2021-02-13

2341 Proton receptors regulate synapse-specific reconsolidation in the amygdala

Koffman, E. E.; Kruse, C. M.; Singh, K.; Naghavi, F. N.; Egbo, J. A.; Boateng, S.; Houdi, M. B.; Lin, B.; Debiec, J.; Du, J.

10.1101/2021.01.04.425235 — neuroscience — Posted on 2021-02-13

2342 Coordination between growth and stress responses by DELLA in the liverwort Marchantia polymorpha

Hernandez-Garcia, J.; Sun, R.; Serrano-Mislata, A.; Inoue, K.; Vargas-Chavez, C.; Esteve-Bruna, D.; Arbona, V.; Yamaoka, S.; Nishihama, R.; Kohchi, T.; Blazquez, M. A.

10.1101/2021.02.11.430820 — plant biology — Posted on 2021-02-13

2343 Dietary restriction in the long-chain acyl-CoA dehydrogenase knockout mouse

Diekman, E.; van Weeghel, M.; Suarez-Farinas, M.; Argmann, C.; Ranea-Robles, P.; Wanders, R.; Visser, G.; van der Made, I.; Creemers, E.; Houten, S.

10.1101/2020.12.03.408591 — physiology — Posted on 2021-02-13

2344 The pharmacodynamic inoculum effect from the perspective of bacterial population modeling

Baeder, D. Y.; Regoes, R. R.

10.1101/550368 — pharmacology and toxicology — Posted on 2021-02-13

2345 Kincore: a web resource for structural classification of protein kinases and their inhibitors

Modi, V.; Dunbrack, R.

10.1101/2021.02.12.430923 — bioinformatics — Posted on 2021-02-13

2346 scAEspy: a tool for autoencoder-based analysis of single-cell RNA sequencing data

Tangherloni, A.; Ricciuti, F.; Besozzi, D.; Lio, P.; Cvejic, A.

10.1101/727867 — bioinformatics — Posted on 2021-02-13

2347 Copy-scAT: Deconvoluting single-cell chromatin accessibility of genetic subclones in cancer

Nikolic, A.; Signal, D.; Ellestad, K.; Johnston, M.; Gillmor, A.; Morrissy, S.; Chan, J. A.; Neri, P.; Bahlis, N.; Gallo, M.

10.1101/2020.09.21.305516 — bioinformatics — Posted on 2021-02-13

2348 FMRP activates the translation of large autism/intellectual disability proteins and stimulates N-end rule E3 ligase Poe/UBR4 production within puromycin-sensitive RNP particles

Greenblatt, E. J.; Spradling, A. C.

10.1101/2020.06.27.174136 — biochemistry — Posted on 2021-02-13

2349 Non-invasive sex genotyping of paiche Arapaima gigas by qPCR: An applied bioinformatic approach to identify sex differences

López-Landavery, E. A.; Corona-Herrera, G. A.; Santos-Rojas, L. E.; Herrera-Castillo, N. M.; Delgadin, T. H.; Tapia-Morales, S.; González-Martinez, S.; Reyes-Flores, L. E.; Marín, A.; Yázsiga-Barrera, C. G.; Fernandino, J. I.; Zelada-Mázmela, E.

10.1101/2021.02.12.430980 — genomics — Posted on 2021-02-13

2350 Profiling of histone H1 variants and changes on genome architecture and gene expression upon histone H1 depletion in breast cancer cells

Serna-Pujol, N.; Salinas-Pena, M.; Mugianesi, F.; Le Dily, F.; Marti-Renom, M. A.; Jordan, A.

10.1101/2021.02.12.429879 — genomics — Posted on 2021-02-13

2351 Strong trait correlation and phylogenetic signal in North American ground beetle (Carabidae) morphology

Stachewicz, J. D.; Fountain-Jones, N. M.; Koontz, A.; Woolf, H.; Pearse, W. D.; Gallinat, A. S.

10.1101/2021.02.12.431029 — evolutionary biology — Posted on 2021-02-13

2352 Sexually antagonistic evolution of mitochondrial and nuclear linkage

Radzvilavicius, A.; Layh, S.; Hall, M. D.; Dowling, D.; Johnston, I.

10.1101/2021.02.12.430938 — evolutionary biology — Posted on 2021-02-13

2353 Quantifying habitat and landscape effects on composition and structure of plant-pollinator networks in the US Northern Great Plains

Vilella-Arnizaut, I. B.; Fenster, C. B.; Nottebrock, H.

10.1101/2021.02.12.431025 — ecology — Posted on 2021-02-13

2354 Disentangling spatial and environmental effects: flexible methods for community ecology and macroecology

Viana, D. S.; Keil, P.; Jeliazkov, A.

10.1101/871251 — ecology — Posted on 2021-02-13

2355 Joint changes in RNA, RNA polymerase II, and promoter activity through the cell cycle identify non-coding RNAs involved in proliferation

Hegre, S. A.; Samdal, H.; Klima, A.; Stovner, E. B.; Norsett, K. G.; Liabakk, N.-B.; Olsen, L. C.; Chawla, K.; Aas, P. A.; Saetrom, P.

10.1101/2021.02.12.430890 — molecular biology — Posted on 2021-02-12

2356 Unbiased profiling of CRISPR RNA-guided transposition products by long-read sequencing

Vo, P. L. H.; Acree, C.; Smith, M. L.; Sternberg, S. H.

10.1101/2021.02.11.430876 — molecular biology — Posted on 2021-02-12

2357 SARS-CoV-2 mutations acquired in mink reduce antibody-mediated neutralization

Hoffmann, M.; Zhang, L.; Krueger, N.; Graichen, L.; Kleine-Weber, H.; Hofmann-Winkler, H.; Kempf, A.; Nessler, S.; Riggert, J.; Winkler, M. S.; Schulz, S.; Jaeck, H.-M.; Poehlmann, S.

10.1101/2021.02.12.430998 — molecular biology — Posted on 2021-02-12

2358 Kinetics and topology of DNA associated with circulating extracellular vesicles released during exercise

Neuberger, E. W. I.; Hillen, B.; Mayr, K.; Simon, P.; Kramer-Albers, E.-M.; Brahmer, A.

10.1101/2021.02.12.430930 — molecular biology — Posted on 2021-02-12

2359 Virus transmission by ultrasonic scaler and its prevention by antiviral agent

Fidler, A.; Steyer, A.; Gaspersic, R.

10.1101/2021.02.10.430630 — microbiology — Posted on 2021-02-12

2360 Salmonella Typhimurium outer membrane protein A (OmpA) renders protection against nitrosative stress by promoting SCV stability in murine macrophage

Roy Chowdhury, A.; Chakravortty, D.

10.1101/2021.02.12.430987 — microbiology — Posted on 2021-02-12

2361 IN VITRO ANTI-VIRAL ACTIVITY OF HEXETIDINE (BACTIDOL) ORAL MOUTHWASH AGAINST HUMAN CORONAVIRUS OC43 ANDINFLUENZA A (H1N1) VIRUS

Altura, M. T.; Ngelangel, C. A.

10.1101/2021.02.11.430728 — microbiology — Posted on 2021-02-12

2362 Do size and shape matter? Exploring the interactions and the metabolome of the soil isolate Hylemonella gracilis

Tyc, O.; Kulkarni, P.; Ossowicki, A.; Tracanna, V.; Medema, M.; Baarlen, P. v.; van IJcken, W.; Verhoeven, K. J. F.; Garbeva, P.

10.1101/2021.02.11.430889 — microbiology — Posted on 2021-02-12

2363 Role of endopeptidases in peptidoglycan synthesis mediated by alternative cross-linking enzymes in Escherichia coli

Voedts, H.; Dorchene, D.; Lodge, A.; Vollmer, W.; Arthur, M.; Hugonnet, J.-E.

10.1101/2021.02.12.430937 — microbiology — Posted on 2021-02-12

2364 Genome sequencing of the bacteriophage CL31 and interaction with the host strain Corynebacterium glutamicum ATCC 13032

Huennefeld, M.; Viets, U.; Sharma, V.; Wirtz, A.; Hardy, A.; Frunzke, J.

10.1101/2021.02.12.430922 — microbiology — Posted on 2021-02-12

2365 Recurrent Vulvovaginal Candidiasis; a dynamic interkingdom biofilm disease of Candida and Lactobacillus

McKloud, E.; Sherry, L.; Kean, R.; Delaney, C.; Williams, S.; Metcalfe, R.; Thomas, R.; Williams, C.; Ramage, G.

10.1101/2021.02.12.430906 — microbiology — Posted on 2021-02-12

2366 Mapping global shifts in Saccharomyces cerevisiae gene expression across asynchronous time trajectories with diffusion maps

Reiter, T.; Montpetit, R.; Runnebaum, R.; Brown, C. T.; Montpetit, B.

10.1101/2021.02.11.430862 — microbiology — Posted on 2021-02-12

2367 Chlorine inactivation of Escherichia coli O157:H7 in fresh produce wash process: effectiveness and modeling

Abnavi, M. D.; Kothapalli, C.; Munther, D.; Srinivasan, P.

10.1101/2021.02.12.430939 — microbiology — Posted on 2021-02-12

2368 Direct-from-specimen microbial growth inhibition spectrums under antibiotic exposure and comparison to conventional antimicrobial susceptibility testing

Chen, J.; San, S. S. S.; Kung, A.; Tomasek, M.; Liu, D.; Rodgers, W.; Gau, V.

10.1101/2021.02.12.430910 — microbiology — Posted on 2021-02-12

2369 TPR1, a novel rifampin derivative demonstrates efficacy alone and in combination with doxycycline against the NIAID Category A Priority Pathogen F. tularensis

Cummings, J. E.; Slayden, K. W.; Slayden, R. A.

10.1101/2021.02.12.431005 — microbiology — Posted on 2021-02-13

2370 Single-cell sequencing of plasma cells from COVID-19 patients reveals highly expanded clonal lineages produce specific and neutralizing antibodies to SARS-CoV-2

Ehling, R. A.; Weber, C. R.; Mason, D. M.; Friedensohn, S.; Wagner, B.; Bieberich, F.; Kapetanovic, E.; Vazquez-Lombardi, R.; Di Roberto, R. B.; Hong, K.-L.; Wagner, C.; Sheward, D. J.; Murrell, B.; Yermanos, A.; Cuny, A.; Savic, M.; Rudolf, F.; Reddy, S. T.

10.1101/2021.02.12.430940 — immunology — Posted on 2021-02-12

2371 Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies

Planas, D.; Bruel, T.; Grzelak, L.; Guivel-Benhassine, F.; Staropoli, I.; Porrot, F.; Planchais, C.; Buchrieser, J.; Rajah, M. M.; Bishop, E.; Albert, M.; Donati, F.; Behillil, S.; Enouf, V.; Marianne, M.; Gonzalez, M.; De Seze, J.; Pere, H.; Veyer, D.; Seve, A.; Simon-Loriere, E.; Fafi-Kremer, S.; Stefic, K.; Mouquet, H.; Hocqueloux, L.; van der Werf, S.; Prazuck, T.; Schwartz, O.

10.1101/2021.02.12.430472 — immunology — Posted on 2021-02-12

2372 Elucidating Mechanisms of Antitumor Immunity Mediated by Live Oncolytic Vaccinia and Heat-Inactivated Vaccinia

Wang, W.; Dai, P.; Liu, S.; Yang, N.; Wang, Y.; Giese, R. A.; Merghoub, T.; Wolchok, J. D.; Deng, L.

10.1101/2021.02.11.427912 — immunology — Posted on 2021-02-12

2373 Development and validation of a mouse model of contemporary cannabis smoke exposure

Fantauzzi, M. F.; Cass, S. P.; McGrath, J. J.; Thayaparan, D.; Wang, P.; Stampfli, M. R.; Hirota, J. A.

10.1101/2021.02.11.430865 — immunology — Posted on 2021-02-13

2374 Sterile Inflammation Alters Neutrophil Kinetics in Mice

Singh, A.; Jothiprakasam, T.; Raghavan, J. V.; Jhunjhunwala, S.

10.1101/2021.02.12.430891 — immunology — Posted on 2021-02-13

2375 Fighting over defence chemicals disrupts mating behaviour

Paul, S. C.; Mueller, C.

10.1101/2021.02.12.430958 — zoology — Posted on 2021-02-13

2376 Single-cell Visualization and Quantification of Trace Metals in Chlamydomonas Lysosome-Related Organelles

Schmollinger, S.; Chen, S.; Strenkert, D.; Hui, C.; Ralle, M.; Merchant, S. S.

10.1101/2021.02.12.431000 — plant biology — Posted on 2021-02-13

2377 Interplay between brassinosteroids and TORC signaling in Arabidopsis revealed by integrated multi-dimensional analysis

Montes, C.; Liao, C.-Y.; Nolan, T. M.; Song, G.; Clark, N. M.; Guo, H.; Bassham, D. C.; Yin, Y.; Walley, J.

10.1101/2021.02.12.431003 — plant biology — Posted on 2021-02-13

2378 Benchmarking Association Analyses of Continuous Exposures with RNA-seq in Observational Studies

Sofer, T.; Kurniansyah, N.; Aguet, F.; Ardlie, K.; Durda, P.; Nickerson, D. A.; Smith, J. D.; Liu, Y.; Gharib, S. A.; Redline, S.; Rich, S. S.; Rotter, J. I.; Taylor, K.

10.1101/2021.02.12.430989 — bioinformatics — Posted on 2021-02-13

2379 StrainFLAIR: Strain-level profiling of metagenomic samples using variation graphs

Da Silva, K.; Pons, N.; Berland, M.; Plaza Onate, F.; Almeida, M.; Peterlongo, P.

10.1101/2021.02.12.430979 — bioinformatics — Posted on 2021-02-13

2380 The Evolution of Chunks in Sequence Learning

Tosatto, L.; Fagot, J.; Nemeth, D.; Rey, A.

10.1101/2021.02.12.430894 — animal behavior and cognition — Posted on 2021-02-12

2381 Computational anatomy and geometric shape analysis enables analysis of complex craniofacial phenotypes in zebrafish mutants

Diamond, K. M.; Rolfe, S. M.; Kwon, R. Y.; Maga, A. M.

10.1101/2021.02.12.431035 — developmental biology — Posted on 2021-02-12

2382 Dopamine modulates visual threat processing in the superior colliculus via D2 receptors

Montardy, Q.; Zhou, Z.; Li, L.; Yang, Q.; Lei, Z.; Feng, X.; Chen, S.; Shi, Q.; Zhang, H.; Chen, S.; Zhang, Z.; Zhao, B.; Xu, F.; Lu, Z.; Wang, L.

10.1101/2021.02.12.430615 — neuroscience — Posted on 2021-02-12

2383 Neural markers for Musical Creativity in Jazz Improvisation and Classical Interpretation

Rahman, S.; Christensen, K.; Jensen, H. J.; Vuust, P.; Bhattacharya, J.

10.1101/2021.02.12.427648 — neuroscience — Posted on 2021-02-12

2384 Promiscuous specialists: Host specificity patterns among generalist louse flies

Lehikoinen, A.; Pohjola, P.; Valkama, J.; Mutanen, M.; Pohjoismäki, J. L. O.

10.1101/2021.02.12.430912 — zoology — Posted on 2021-02-12

2385 Life histories as mosaics: plastic and genetic components differ among traits that underpin life-history strategies

Felmy, A.; Reznick, D. N.; Travis, J.; Potter, T.; Coulson, T.

10.1101/2021.02.12.430905 — evolutionary biology — Posted on 2021-02-12

2386 Dynamics of primary productivity in relation to submerged vegetation of a shallow, eutrophic lagoon: a field and mesocosm study

Berthold, M.; Paar, M.

10.1101/2021.02.12.430911 — ecology — Posted on 2021-02-12

2387 KCTD19 associates with ZFP541 and HDAC1 and is required for meiotic exit in male mice

Oura, S.; Koyano, T.; Kodera, C.; Horisawa-Takada, Y.; Matsuyama, M.; Ishiguro, K.-i.; Ikawa, M.

10.1101/2021.02.12.430913 — developmental biology — Posted on 2021-02-12

2388 Using a Human Circulation Mathematical Model to Simulate the Effects of Hemodialysis and Therapeutic Hypothermia.

Joseph, J. J.; Hunter, T. J.; Sun, C.; Goldman, D.; Kharche, S. R.; McIntyre, C. W.

10.1101/2021.02.11.430843 — biophysics — Posted on 2021-02-12

2389 Lack of parent-of-origin effects in Nasonia jewel wasp: a replication and extension study

Olney, K. C.; Gibson, J. D.; Natri, H. M.; Underwood, A.; Gadau, J.; Wilson, M. A.

10.1101/2021.02.11.430138 — genomics — Posted on 2021-02-12

2390 Arboreal aperitifs: Space use and activity of a major songbird nest predator in a tropical Thailand forest

D'souza, A.; Gale, G. A.; Marshall, B. M.; Khamcha, D.; Waengsothorn, S.; Strine, C. T.

10.1101/2021.02.09.430242 — ecology — Posted on 2021-02-12

2391 Relationships between biomechanical parameters, neurological recovery, and neuropathology following concussion in swine

Wofford, K. L.; Grovola, M. R.; Adewole, D. O.; Browne, K. D.; Putt, M. E.; O'Donnell, J. C.; Cullen, D. K.

10.1101/2021.02.09.430268 — neuroscience — Posted on 2021-02-12

2392 Targeting Gys1 with AAV-SaCas9 decreases pathogenic polyglucosan bodies and neuroinflammation in Adult Polyglucosan Body and Lafora disease mouse models

Gumusgoz, E.; Guisso, D. R.; Kasiri, S.; Wu, J.; Dear, M.; Verhalen, B.; Nitschke, S.; Mitra, S.; Nitschke, F.; Minassian, B. A.

10.1101/2021.02.12.430952 — neuroscience — Posted on 2021-02-12

2393 Decrease of Functional Connectivity within the Default Mode Network by a Brief Training of Focused Attention on the Breath in Novices

Trova, S.; Tsuji, Y.; Horiuchi, H.; Shimada, S.

10.1101/2021.02.09.430388 — neuroscience — Posted on 2021-02-12

2394 tDCS modulates effective connectivity during motor command following; a potential therapeutic target for disorders of consciousness

Aloi, D.; Jalali, R.; Tilsley, P.; Miall, C. R.; Fernandez-Espejo, D.

10.1101/2021.02.09.430392 — neuroscience — Posted on 2021-02-12

2395 A Geometric Framework for Understanding Dynamic Information Integration in Context-Dependent Computation

Zhang, X.; Liu, S.; Chen, Z. S.

10.1101/2021.02.09.430498 — neuroscience — Posted on 2021-02-12

2396 Thresholded Partial Least Squares: Fast Construction of Interpretable Whole-brain Decoders

Lee, S.; Bradlow, E. T.; Kable, J. W.

10.1101/2021.02.09.430524 — neuroscience — Posted on 2021-02-12

2397 Locomotor performance and CNS responses to hypoxia in a cyclic nucleotide-gated channel mutant of adult Drosophila

Qiu, S.; Xiao, C.; Robertson, M.

10.1101/2021.02.11.430836 — physiology — Posted on 2021-02-12

2398 Targeted enzyme assisted chemotherapy (TEAC) - a novel microRNA-guided and selenium-based regimen to specifically eradicate hepatocellular carcinoma

Selvam, A. K.; Bjornstedt, M.; Jawad, R.; Gramignoli, R.; Achour, A.; Salter, H.

10.1101/2021.02.09.430426 — cancer biology — Posted on 2021-02-12

2399 Understanding conformational dynamics from macromolecular crystal diffuse scattering

Mazumder, P.; Ayyer, K.

10.1101/2021.02.11.429988 — biophysics — Posted on 2021-02-12

2400 The clinical and functional effects of TERT variants in myelodysplastic syndrome

Reilly, C. R.; Myllymaki, M.; Redd, R.; Padmanaban, S.; Karunakaran, D.; Tesmer, V.; Tsai, F. D.; Gibson, C. J.; Rana, H. Q.; Zhong, L.; Saber, W.; Spellman, S. R.; Hu, Z.-H.; Orr, E. H.; Chen, M. M.; De Vivo, I.; Cutler, C.; Antin, J. H.; Neuberg, D.; Garber, J. E.; Nandakumar, J.; Agarwal, S.; Lindsley, R. C.

10.1101/2021.02.11.430624 — genetics — Posted on 2021-02-12

2401 Unexpected organellar locations of ESCRT machinery in Giardia intestinalis and complex evolutionary dynamics spanning the transition to parasitism in the lineage Fornicata

Pipaliya, S. V.; Santos, R.; Salas-Leiva, D.; Balmer, E. A.; Wirdnam, C. D.; Roger, A.; Hehl, A. B.; Faso, C.; Dacks, J. B.

10.1101/2021.02.11.430673 — evolutionary biology — Posted on 2021-02-12

2402 Schizophrenia-linked protein tSNARE1 regulates endolysosomal trafficking in cortical neurons

Plooster, M.; Farrell, M. S.; Rossi, G.; Won, H.; Gupton, S. L.; Brennwald, P. J.

10.1101/2021.02.09.430442 — neuroscience — Posted on 2021-02-12

2403 Get rid of the beat in mobile EEG applications: A framework towards automated cardiogenic artifact detection and removal in single-channel EEG

Chiu, N.-T.; Huwiler, S.; Ferster, M. L.; Karlen, W.; Wu, H.-T.; Lustenberger, C.

10.1101/2021.02.09.430184 — neuroscience — Posted on 2021-02-12

2404 Beyond massive univariate tests: Covariance regression reveals complex patterns of functional connectivity related to attention-deficit/hyperactivity disorder, age, sex, and response control

Zhao, Y.; Nebel, M. B.; Caffo, B. S.; Mostofsky, S. H.; Rosch, K. S.

10.1101/2021.02.09.430522 — neuroscience — Posted on 2021-02-12

2405 Cancer cells induce hepatocytes apoptosis in co-opted colorectal cancer liver metastatic lesions

Rada, M.; Tsamchoe, M.; Kapelanski-Lamoureux, A.; Bloom, J.; Petrillo, S.; Kim, D. H.; Lazaris, A.; Metrakos, P.

10.1101/2021.02.11.429243 — cancer biology — Posted on 2021-02-12

2406 Different trajectories of polyploidization shape the genomic landscape of the Brettanomyces bruxellensis yeast species

Eberlein, C.; Abou Saada, O.; Friedrich, A.; Albertin, W.; Schacherer, J.

10.1101/2021.02.11.430840 — genomics — Posted on 2021-02-12

2407 The C. elegans Notch proteins LIN-12 and GLP-1 are tuned to lower force thresholds for activation than Drosophila Notch

Langridge, P. D.; Chan, J. Y.; Garcia-Diaz, A.; Greenwald, I.; Struhl, G.

10.1101/2021.02.11.429991 — developmental biology — Posted on 2021-02-12

2408 Parameter estimation for correlated Ornstein-Uhlenbeck time-series

Strey, H. H.; Kumar, R.; Mujica-Parodi, L. R.

10.1101/2021.02.12.430978 — neuroscience — Posted on 2021-02-12

2409 Phenotypic analysis of catastrophic childhood epilepsy genes: The Epilepsy Zebrafish Project

Griffin, A.; Carpenter, C.; Liu, J.; Grone, B.; Hamling, K.; Moog, M.; Dinday, M. T.; Figueroa, F.; Anvar, M.; Ononuju, C.; Qu, T.; Baraban, S. C.

10.1101/2021.02.11.430844 — neuroscience — Posted on 2021-02-12

2410 Postpartum corticosterone and fluoxetine shift the tryptophan-kynurenine pathway in dams

Qiu, W.; Go, K.; Lamers, Y.; Galea, L.

10.1101/2021.02.11.430473 — neuroscience — Posted on 2021-02-12

2411 Abrupt remapping in human CA3/dentate gyrus signals resolution of memory interference

Guo, W.; Favila, S. E.; Kim, G.; Molitor, R. J.; Kuhl, B. A.

10.1101/2021.02.11.430826 — neuroscience — Posted on 2021-02-12

2412 Musicianship and melodic predictability enhance neural gain in auditory cortex during pitch deviance detection

Quiroga-Martinez, D. R.; Hansen, N. C.; Hojlund, A.; Pearce, M.; Brattico, E.; Holmes, E.; Friston, K.; Vuust, P.

10.1101/2021.02.11.430838 — neuroscience — Posted on 2021-02-12

2413 Multi-channel 4D parametrized Atlas of Macro- and Microstructural Neonatal Brain Development

Uus, A.; Grigorescu, I.; Pietsch, M.; Batalle, D.; Christiaens, D.; Hughes, E.; Hutter, J.; Cordero Grande, L.; Price, A. N.; Tournier, J.-D.; Rutherford, M. A.; Counsell, S. J.; Hajnal, J. V.; Edwards, A. D.; Deprez, M.

10.1101/2021.02.11.430835 — neuroscience — Posted on 2021-02-12

2414 Photoperiod shapes aluminium tolerance in plants

Siqueira, J. A.; Wakin, T.; Batista-Silva, W.; Silva, J. C. F.; Vicente, M. H.; Silva, J. C.; Clarindo, W. R.; Zsogon, A.; Peres, L.; De Veylder, L.; Fernie, A. R.; Nunes-Nesi, A.; Araujo, W. L.

10.1101/2021.02.12.430934 — plant biology — Posted on 2021-02-12

2415 Integration of electric, calcium, reactive oxygen species and hydraulic signals during rapid systemic signaling in plants

Fichman, Y.; Mittler, R.

10.1101/2021.02.12.430927 — plant biology — Posted on 2021-02-12

2416 Anti-diabetic effects of Holarrhena antidysentrica extracts: Results from a Longitudinal Meta-analysis

Das, M.; Divya, C. A.; Dhar, S. K.; Shantaram, M.

10.1101/2021.02.11.430868 — plant biology — Posted on 2021-02-12

2417 An improved ChEC-seq method accurately maps the genome-wide binding of transcription coactivators and sequence-specific transcription factors

Donczew, R.; Lalou, A.; Devys, D.; Tora, L.; Hahn, S.

10.1101/2021.02.12.430999 — genomics — Posted on 2021-02-12

2418 The role of auxin and sugar signaling in dominance inhibition of inflorescence growth by fruit load

Smith, H. M.; Goetz, M.; Rabinovich, M.

10.1101/2021.02.12.430977 — plant biology — Posted on 2021-02-12

2419 The making of cauliflowers: the story of unsuccessful flowers

Azpeitia, E.; Tichtinsky, G.; Le Masson, M.; Serrano-Mislata, A.; Gregis, V.; Gimenez, C.; Prunet, N.; Lucas, J.; Farcot, E.; Kater, M.; Bradley, D.; Madueno, F.; Godin, C.; Parcy, F.

10.1101/2021.02.12.427428 — plant biology — Posted on 2021-02-12

2420 Extensive N4 cytosine methylation is essential for Marchantia sperm function

Walker, J.; Zhang, J.; Liu, Y.; Vickers, M.; Dolan, L.; Nakajima, K.; Feng, X.

10.1101/2021.02.12.428880 — developmental biology — Posted on 2021-02-12

2421 Alternative female and male developmental strategies in the dynamic balance of human visual perception

Ziman, G.; Aleshin, S.; Unoka, Z.; Braun, J.; Kovacs, I.

10.1101/2021.02.11.430816 — neuroscience — Posted on 2021-02-12

2422 Extensive introgression among North American wild grapes (Vitis) fuels biotic and abiotic adaptation

Morales-Cruz, A.; Aguirre-Liguori, J.; Zhou, Y.; Minio, A.; Riaz, S.; Walker, A. M.; Cantu, D.; Gaut, B. S.

10.1101/2021.02.11.430822 — evolutionary biology — Posted on 2021-02-12

2423 The genetic basis of adaptation through the evolution of mating systems

Xu, K.

10.1101/2021.02.11.430833 — evolutionary biology — Posted on 2021-02-12

2424 Identification of phenotype-specific networks from paired gene expression-cell shape imaging data

Barker, C. G.; Petsalaki, E.; Giudice, G.; Ekpenyong, E. N.; Bakal, C.; Petsalaki, E.

10.1101/2021.02.11.430597 — systems biology — Posted on 2021-02-12

2425 Development of an exosomal biomarker signature to detect minimal residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning

Makielski, K.; Donnelly, A. J.; Khammanivong, A.; Scott, M. C.; Ortiz, A. R.; Galvan, D. C.; Tomiyasu, H.; Amaya, C.; Ward, K.; Montoya, A.; Garbe, J. R.; Mills, L. J.; Cutter, G. R.; Fenger, J. M.; Kisseberth, W. C.; O'Brien, T. D.; Spector, L. G.; Bryan, B. A.; Subramanian, S.; Modiano, J. F.

10.1101/2021.02.11.429432 — cancer biology — Posted on 2021-02-12

2426 Local thermodynamics governs the formation and dissolution of protein condensates in living cells

Fritsch, A. W.; Diaz-Delgadillo, A. F.; Adame-Arana, O.; Hoege, C.; Kreysing, M.; Mittasch, M.; Leaver, M.; Hyman, A. A.; Julicher, F.; Weber, C. A.

10.1101/2021.02.11.430794 — biophysics — Posted on 2021-02-12

2427 The bacterial iron sensor IdeR recognizes its DNA targets by indirect readout

Marcos-Torres, F. J.; Maurer, D.; Griese, J. J.

10.1101/2021.02.12.430932 — biochemistry — Posted on 2021-02-12

2428 Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex

Hallett, S. T.; Schellenberger, P.; Zhou, L.; Beuron, F.; Morris, E.; Murray, J. M.; Oliver, A.

10.1101/2021.02.12.430902 — biochemistry — Posted on 2021-02-12

2429 Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry

Lei, X.; Wei, T.; Wang, J.; Liang, R.; Chen, W.; He, A.; Du, Y.; Zhou, W.; Zhang, Z.; Ma, M.; Lu, J.; Guo, X.; Chen, X.; Tian, R.; Xiao, J.

10.1101/2021.02.12.430909 — biochemistry — Posted on 2021-02-12

2430 Elucidating vimentin interaction with zinc ions and its interplay with oxidative modifications through crosslinking assays and molecular dynamics simulations

Monico, A.; Guzman-Caldentey, J.; Pajares, M. A.; Martin-Santamaria, S.; Perez-Sala, D.

10.1101/2021.02.12.430929 — biochemistry — Posted on 2021-02-12

2431 Dynamics and modulation of the human snoRNome

Fafard-Couture, E.; Bergeron, D.; Couture, S.; Abou Elela, S.; Scott, M. S.

10.1101/2021.02.11.430834 — genomics — Posted on 2021-02-12

2432 miR-34a is not a candidate tumor suppressor

Seitz, H.; Houbron, E.; Mockly, S.

10.1101/2021.02.11.430795 — genetics — Posted on 2021-02-12

2433 Post mortem validation of DSI compressed sensing with optical imaging

Jones, R.; Maffei, C.; Augustinack, J.; Fischl, B.; Wang, H.; Bilgic, B.; Yendiki, A.

10.1101/2021.02.11.430672 — neuroscience — Posted on 2021-02-12

2434 Lack of effect of different pain-related manipulations on opioid self-administration, reinstatement of opioid seeking, and opioid choice in rats

Reiner, D. J.; Townsend, E. A.; Menendez, J. O.; Applebey, S. V.; Claypool, S. M.; Banks, M. J.; Shaham, Y.; Negus, S. S.

10.1101/2021.02.11.430808 — neuroscience — Posted on 2021-02-12

2435 Physical phenotype of blood cells is altered in COVID-19

Kubankova, M.; Hohberger, B.; Hoffmanns, J.; Fuerst, J.; Hermann, M.; Guck, J.; Krater, M.

10.1101/2021.02.12.429482 — biophysics — Posted on 2021-02-12

2436 BIAPSS - BioInformatic Analysis of liquid-liquid Phase-Separating protein Sequences

Badaczewska-Dawid, A.; Potoyan, D. A.

10.1101/2021.02.11.430806 — bioinformatics — Posted on 2021-02-12

2437 Learning Sparse Log-Ratios for High-Throughput Sequencing Data

Gordon-Rodriguez, E.; Quinn, T. P.; Cunningham, J. P.

10.1101/2021.02.11.430695 — bioinformatics — Posted on 2021-02-12

2438 Evidence for Multiple Teosinte Hybrid Zones in Central Mexico

Hufnagel, D. E.; Kananen, K.; Glaubitz, J. C.; Sanchez-Gonzalez, J. d. J.; Doebley, J. F.; Hufford, M. B.

10.1101/2021.02.11.430632 — evolutionary biology — Posted on 2021-02-12

2439 Reproductive plasticity in both sexes interacts to determine mating behaviour and fecundity

Fowler, E. K.; Leigh, S.; Bretman, A.; Chapman, T.

10.1101/2021.02.11.430788 — evolutionary biology — Posted on 2021-02-12

2440 In vitro evolution of Remdesivir resistance reveals genome plasticity of SARS-CoV-2

Szemiel, A. M.; Merits, A.; Orton, R. J.; MacLean, O.; Wickenhagen, A.; Lieber, G.; Pinto, R. M.; Turnbull, M. L.; Wang, S.; Mair, D.; da Silva Filipe, A.; Willett, B. J.; Wilson, S. J.; Patel, A. H.; Thomson, E. C.; Palmarini, M.; Kohl, A.; Stewart, M. E.

10.1101/2021.02.01.429199 — microbiology — Posted on 2021-02-12

2441 Surface-aerosol stability and pathogenicity of diverse MERS-CoV strains from 2012 - 2018

van Doremalen, N.; Letko, M. C.; Fischer, R.; Bushmaker, T.; Yinda, K. C.; Schulz, J.; Seifert, S. N.; Kim, N. J.; Hemida, M. G.; Kayali, G.; Park, W. B.; Perera, R.; Tamin, A.; Thornburg, N. J.; Tong, S.; Queen, K.; Van Kerkhove, M. D.; Choi, Y. K.; Oh, M.-d.; Assiri, A. M.; Peiris, J. S. M.; Gerber, S.; Munster, V.

10.1101/2021.02.11.429193 — microbiology — Posted on 2021-02-12

2442 A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection

Liu, H.; Yuan, M.; Huang, D.; Bangaru, S.; Lee, C.-C. D.; Peng, L.; Zhu, X.; Nemazee, D.; van Gils, M. J.; Sanders, R. W.; Kornau, H.-C.; Reincke, S. M.; Pruss, H.; Kreye, J.; Wu, N. C.; Ward, A. B.; Wilson, I. A.

10.1101/2021.02.11.430866 — microbiology — Posted on 2021-02-12

2443 Rapidly Increasing SARS-CoV-2 Neutralization by Intravenous Immunoglobulins Produced from Plasma Collected During the 2020 Pandemic

Farcet, M. R.; Karbiener, M.; Schwaiger, J.; Ilk, R.; Kreil, T. R.

10.1101/2021.02.12.430933 — immunology — Posted on 2021-02-12

2444 A single-cell atlas of lymphocyte adaptive immune repertoires and transcriptomes reveals age-related differences in convalescent COVID-19 patients

Bieberich, F.; Vazquez-Lombardi, R.; Yermanos, A.; Ehling, R. A.; Wagner, B.; Kapetanovic, E.; Di Roberto, R. B.; Savic, M.; Rudolf, F.; Reddy, S. T.

10.1101/2021.02.12.430907 — immunology — Posted on 2021-02-12

2445 Regulation of PD1 signaling is associated with prognosis in glioblastoma multiforme

Lopes-Ramos, C. M.; Belova, T.; Brunner, T.; Quackenbush, J.; Kuijjer, M. L.

10.1101/2021.02.11.430786 — systems biology — Posted on 2021-02-12

2446 Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19

Boras, B.; Jones, R. M.; Anson, B. J.; Arenson, D.; Aschenbrenner, L.; Bakowski, M. A.; Beutler, N.; Binder, J.; Chen, E.; Eng, H.; Hammond, J.; Hoffman, R.; Kadar, E. P.; Kania, R.; Kimoto, E.; Kirkpatrick, M. G.; Lanyon, L.; Lendy, E. K.; Lillis, J. R.; Luthra, S. A.; Ma, C.; Noell, S.; Obach, R. S.; O'Brien, M. N.; O'Connor, R.; Ogilvie, K.; Owen, D.; Pettersson, M.; Reese, M. R.; Rogers, T.; Rossulek, M. I.; Sathish, J. G.; Steppan, C.; Ticehurst, M.; Updyke, L. W.; Zhu, Y.; Wang, J.; Chatterjee, A. K.; Mesecar, A. D.; Anderson, A. S.; Allerton, C.; Frieman, M.; Weston, S.; McGrath, M. E.;

10.1101/2020.09.12.293498 — pharmacology and toxicology — Posted on 2021-02-12

2447 Vimentin Intermediate Filaments Stabilize Dynamic Microtubules by Direct Interactions

Schaedel, L.; Lorenz, C.; Schepers, A. V.; Klumpp, S.; Köster, S.

10.1101/2020.05.20.106179 — biophysics — Posted on 2021-02-12

2448 The COVID-19 PHARMACOME: A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization

Schultz, B. T.; Zaliani, A.; Ebeling, C.; Reinshagen, J.; Bojkova, D.; Lage-Rupprecht, V.; Karki, R.; Lukassen, S.; Gadiya, Y.; Ravindra, N. G.; Das, S.; Baksi, S.; Domingo-Fernandez, D.; Lentzen, M.; Strivens, M.; Raschka, T.; Cinatl, J.; DeLong, L. N.; Gribbon, P.; Geisslinger, G.; Ciesek, S.; van Dijk, D.; Gardner, S.; Tom Kodamullil, A.; Froehlich, H.; Peitsch, M.; Jacobs, M.; Hoeng, J.; Eils, R.; Claussen, C.; Hofmann-Apitius, M.

10.1101/2020.09.23.308239 — bioinformatics — Posted on 2021-02-12

2449 NIAGADS Alzheimer's GenomicsDB: A resource for exploring Alzheimer's Disease genetic and genomic knowledge

Greenfest-Allen, E.; Klamann, C.; Gangadharan, P.; Kuzma, A.; Leung, Y. Y.; Valladares, O.; Schellenberg, G.; Stoeckert, C. J.; Wang, L.-S.

10.1101/2020.09.23.310276 — bioinformatics — Posted on 2021-02-12

2450 Joint inference of species histories and gene flow

Mueller, N. F.; Ogilvie, H.; Zhang, C.; Fontaine, M. C.; Amaya-Romero, J. E.; Drummond, A.; Stadler, T.

10.1101/348391 — evolutionary biology — Posted on 2021-02-12

2451 Individual tree-crown detection in RGB imagery using semi-supervised deep learning neural networks

Weinstein, B.; Marconi, S.; Bohlman, S.; Zare, A.; White, E.

10.1101/532952 — ecology — Posted on 2021-02-12

2452 Two distinct bacterial biofilm components trigger metamorphosis in the colonial hydrozoan Hydractinia echinata

Guo, H.; Rischer, M.; Westermann, M.; Beemelmanns, C.

10.1101/2019.12.23.887182 — ecology — Posted on 2021-02-12

2453 Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7

Wang, P.; Nair, M. S.; Liu, L.; Iketani, S.; Luo, Y.; Guo, Y.; Wang, M.; Yu, J.; Zhang, B.; Kwong, P. D.; Graham, B. S.; Mascola, J. R.; Chang, J. Y.; Yin, M. T.; Sobieszczyk, M. E.; Kyratsous, C. A.; Shapiro, L.; Sheng, Z.; Huang, Y.; Ho, D. D.

10.1101/2021.01.25.428137 — immunology — Posted on 2021-02-12

2454 Cone mitochondria act as microlenses to enhance light delivery and confer Stiles-Crawford-like direction sensitivity

Ball, J. M.; Chen, S.; Li, W.

10.1101/2021.02.11.430818 — neuroscience — Posted on 2021-02-12

2455 siRNA enrichment in Argonaute 2-depleted Blattella germanica

Montanes, J. C.; Rojano, C.; Ylla, G.; Piulachs, M.-D.; Maestro, J. L.

10.1101/2021.02.11.430758 — physiology — Posted on 2021-02-12

2456 Substrates modulate charge-reorganization allosteric effects in protein-protein association

Banerjee-Ghosh, K.; Ghosh, S.; Levy, D.; Riven, I.; Naaman, R.; Haran, G.

10.1101/2021.02.11.430712 — biophysics — Posted on 2021-02-12

2457 Ribovore: ribosomal RNA sequence analysis for GenBank submissions and database curation

Schäffer, A. A.; McVeigh, R.; Robbertse, B.; Schoch, C. L.; Johnston, A.; Underwood, B. A.; Karsch-Mizrachi, I.; Nawrocki, E. P.

10.1101/2021.02.11.430762 — bioinformatics — Posted on 2021-02-12

2458 A benchmarking of human mitochondrial DNA haplogroup classifiers from whole-genome and whole-exome sequence data

10.1101/2021.02.11.430775 — genomics — Posted on 2021-02-12

2459 Optimal Linkage Disequilibrium Splitting

Prive, F.

10.1101/2021.02.11.430793 — genetics — Posted on 2021-02-12

2460 Identification of a rapidly-spreading triple mutant for high-level metabolic insecticide resistance in Anopheles gambiae provides a real-time molecular diagnostic for anti-malarial intervention deployment.

Njoroge, H.; van't Hof, A.; Oruni, A.; Pipini, D.; Nagi, S. C.; Lynd, A.; Lucas, E. R.; Tomlinson, S.; Grau-Bove, X.; McDermott, D.; Wat'senga, F. t.; Manzambi, E. Z.; Agossa, F. R.; Mokuba, A.; Kabula, B.; Mbogo, C.; Bargul, J.; Paine, M. J.; Weetman, D.; Donnelly, M. J.

10.1101/2021.02.11.429702 — evolutionary biology — Posted on 2021-02-12

2461 Genetic determinants facilitating the evolution of resistance to carbapenem antibiotics

Hung, D.; Ma, P.; He, L. L.; Pironti, A.; Laibinis, H. H.; Ernst, C. M.; Manson, A. L.; Bhattacharyya, R. P.; Earl, A.; Livny, J.

10.1101/2021.02.11.430761 — evolutionary biology — Posted on 2021-02-12

2462 Cooperative virulence can emerge via horizontal gene transfer but is stabilized by transmission

Bakkeren, E.; Gul, E.; Huisman, J. S.; Steiger, Y.; Rocker, A.; Hardt, W.-D.; Diard, M.

10.1101/2021.02.11.430745 — evolutionary biology — Posted on 2021-02-12

2463 REAP: A platform to identify autoantibodies that target the human exoproteome

Wang, E. Y.; Dai, Y.; Rosen, C. E.; Schmitt, M. M.; Dong, M. X.; Ferre, E. M. N.; Liu, F.; Yang, Y.; Gonzalez-Hernandez, J. A.; Meffre, E.; Hinchcliffe, M.; Koumpouras, F.; Lionakis, M. S.; Ring, A. M.

10.1101/2021.02.11.430703 — immunology — Posted on 2021-02-12

2464 Autocrine regulation of adult neurogenesis by the endocannabinoid 2-arachidonoylglycerol (2-AG)

Schuele, L.-L.; Schuermann, B.; Bilkei-Gorzo, A.; Zimmer, A.; Leidmaa, E.

10.1101/2021.02.11.430731 — neuroscience — Posted on 2021-02-12

2465 Impulsivity and Emotional Dysregulation Predict Choice Behavior During a Competitive Multiplayer Game in Adolescents with Borderline Personality Disorder

Parr, A. C.; Calancie, O. G.; Coe, B.; Khalid-Khan, S.; Munoz, D. P.

10.1101/2021.02.11.430783 — neuroscience — Posted on 2021-02-12

2466 Disordered information processing dynamics in experimental epilepsy

Clawson, W.; Madec, T.; Ghestem, A.; Quilichini, P. P.; Battaglia, D.; Bernard, C.

10.1101/2021.02.11.430768 — neuroscience — Posted on 2021-02-12

2467 Evolutionary divergence of locomotion in two related vertebrate species

Rajan, G.; Lafaye, J.; Carbo-Tano, M.; Duroure, K.; Faini, G.; Tanese, D.; Panier, T.; Candelier, R.; Henninger, J.; Britz, R.; Judkewitz, B.; Gebhardt, C.; Emiliani, V.; Debregeas, G.; Wyart, C.; Del Bene, F.

10.1101/2021.02.11.430752 — neuroscience — Posted on 2021-02-12

2468 Predicting behavior from eye movement and whisking asymmetry

Bergmann, R.; Sehara, K.; Dominiak, S.; Kremkow, J.; Larkum, M.; Sachdev, R.

10.1101/2021.02.11.430785 — neuroscience — Posted on 2021-02-12

2469 Stress induced Differential Expression of THAP9 & THAP9-AS1 in the S-phase of cell cycle.

Sharma, V.; Thakore, P.; Krishnan, M.; Majumdar, S.

10.1101/2021.02.11.430738 — molecular biology — Posted on 2021-02-12

2470 Acute stress blunts prediction error signals in the dorsal striatum during reinforcement learning

Carvalheiro, J.; Conceicao, V. A.; Mesquita, A.; Seara-Cardoso, A.

10.1101/2021.02.11.430640 — neuroscience — Posted on 2021-02-12

2471 Motor planning under uncertainty

Alhussein, L.; Smith, M. A.

10.1101/2021.02.11.430753 — neuroscience — Posted on 2021-02-12

2472 White-box Deep Neural Network Prediction of Genome-Wide Transcriptome Signatures

Magnusson, R.; Tegner, J.; Gustafsson, M.

10.1101/2021.02.11.430730 — systems biology — Posted on 2021-02-12

2473 Comparative Chromatin Dynamics of Stem Cell Differentiation in Human and Rat

Thai, C. W.; Jiang, S.; Roxas, Y.; McGill, C.; Ma, S.; Mortazavi, A.

10.1101/2021.02.11.430819 — genomics — Posted on 2021-02-12

2474 Re-investigation of classic T cell subsets and identification of novel cell subpopulations by single-cell RNA sequencing

Wang, X.; Shen, X.; Chen, S.; Liu, H.; Hong, N.; Chen, X.; Jin, W.

10.1101/2021.02.11.430754 — genomics — Posted on 2021-02-12

2475 Polygenic Prediction of Type 2 Diabetes in Continental Africa

Chikowore, T.; Ekoru, K.; Vujkovic, M.; Gill, D.; Pirie, F.; Young, E.; Sandhu, M.; McCarthy, M.; Rotimi, C.; Adeyemo, A.; Motola, A.; Fatumo, S.

10.1101/2021.02.11.430719 — genetics — Posted on 2021-02-12

2476 With great power comes great responsibility: an analysis of sustainable forest management quantitative indicators in the DPSIR framework

Paillet, Y.; Campagnaro, T.; Burrascano, S.; Gosselin, M.; Ballweg, J.; Chianucci, F.; Dorioz, J.; Marsaud, J.; Maciejewski, L.; Sitzia, T.; Vacchiano, G.

10.1101/2021.02.11.430737 — ecology — Posted on 2021-02-12

2477 Polymetallic nodules are essential for food-web integrity of a prospective deep-seabed mining area in Pacific abyssal plains

Stratmann, T.; Soetaert, K.; Kersken, D.; van Oevelen, D.

10.1101/2021.02.11.430718 — ecology — Posted on 2021-02-12

2478 Top-down attention modulates auditory-evoked neural responses in neurotypical, but not ADHD, young adults

Kwasa, J. A. C.; Noyce, A. L.; Torres, L. M.; Shinn-Cunningham, B. G.

10.1101/2021.02.11.430824 — neuroscience — Posted on 2021-02-12

2479 The relationship between affective visual mismatch negativity to interpersonal difficulties across autism and schizotypal traits

Ford, T. C.; Hugrass, L. E.; Jack, B. N.

10.1101/2021.02.11.430861 — neuroscience — Posted on 2021-02-12

2480 A compact spatial map in V2 visual cortex

Long, X.; Deng, B.; Cai, J.; Chen, Z. S.; Zhang, S.-J.

10.1101/2021.02.11.430687 — neuroscience — Posted on 2021-02-12

2481 Environmental responsiveness of flowering time in cassava genotypes and associated transcriptome changes

Oluwasanya, D. N.; Gisel, A.; Stavolone, L.; Setter, T. L.

10.1101/2021.02.11.430817 — plant biology — Posted on 2021-02-12

2482 Interdependent Iron and Phosphorus Availability Controls Photosynthesis Through Retrograde Signaling

Nam, H.-I.; Shahzad, Z.; Dorone, Y.; Clowez, S.; Zhao, K.; Bouain, N.; Cho, H.; Rhee, S. Y.; Rouached, H.

10.1101/2021.02.11.430802 — plant biology — Posted on 2021-02-12

2483 Coordination between growth and stress responses by DELLA in the liverwort Marchantia polymorpha

Hernandez-Garcia, J.; Sun, R.; Serrano-Mislata, A.; Inoue, K.; Vargas-Chavez, C.; Esteve-Bruna, D.; Arbona, V.; Yamaoka, S.; Nishihama, R.; Kohchi, T.; Blazquez, M. A.

10.1101/2021.02.11.430820 — plant biology — Posted on 2021-02-12

2484 Seasonal Abundance and Spatial Pattern of Distribution of Liriomyza trifolii (Diptera: Agromyzidae) and Its Parasitoid on Bean and Squash in South Florida.

Devkota, S.; Seal, D. R.

10.1101/2021.02.11.430801 — plant biology — Posted on 2021-02-12

2485 Polarly localized receptor-like kinases PXC2 and IRK act redundantly during Arabidopsis root development in the radial axis

Goff, J.; Van Norman, J. M.

10.1101/2021.02.11.429611 — plant biology — Posted on 2021-02-12

2486 Transcriptome and metabolome analyses revealed that narrowband 280 and 310 nm UV-B induce distinctive responses in Arabidopsis

Tsurumoto, T.; Fujikawa, Y.; Ohta, D.; Okazawa, A.

10.1101/2021.02.12.430709 — plant biology — Posted on 2021-02-12

2487 Accumulation of somatic mutations leads to genetic mosaicism in Cannabis

Adamek, K.; Torkamaneh, D.; Jones, A. M. P.

10.1101/2021.02.11.430823 — plant biology — Posted on 2021-02-12

2488 A robust method of nuclei isolation for single-cell RNA sequencing of solid tissues from the plant genus Populus

Conde, D.; Triozzi, P. M.; Balmant, K. M.; Doty, A. L.; Miranda, M.; Boullosa, A.; Schmidt, H. W.; Pereira, W. J.; Dervinis, C.; Kirst, M.

10.1101/2021.02.11.430521 — plant biology — Posted on 2021-02-12

2489 ChEC-seq produces robust and specific maps of transcriptional regulators

Zentner, G. E.; Policastro, R. A.; Henikoff, S.

10.1101/2021.02.11.430831 — genomics — Posted on 2021-02-12

2490 Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19

Feyaerts, D.; Hedou, J.; Gillard, J.; Chen, H.; Tsai, E. S.; Peterson, L. S.; Ando, K.; Manohar, M.; Do, E.; Dhondalay, G. K. R.; Fitzpatrick, J.; Artandi, M.; Chang, I.; Snow, T. T.; Chinthrajah, R. S.; Warren, C. M.; Wittman, R.; Meyerowitz, J. G.; Ganio, E. A.; Stelzer, I. A.; Han, X.; Verdonk, F.; Gaudilliere, D. K.; Mukherjee, N.; Tsai, A. S.; Rumer, K. K.; Jiang, S. J.; Valdes-Ferrer, S. I.; Kelly, J. D.; Furman, D.; Aghaeepour, N.; Angst, M. S.; Boyd, S. D.; Pinsky, B. A.; Nolan, G. P.; Nadeau, K. C.; Gaudilliere, B.; McIlwain, D. R.

10.1101/2021.02.09.430269 — immunology — Posted on 2021-02-12

2491 Dual mTORC1/mTORC2 inhibition as a Host-Directed Therapeutic Target in Pathologically Distinct Mouse Models of Tuberculosis

Tasneen, R.; Mortensen, D. S.; Converse, P. J.; Urbanowski, M. E.; Upton, A.; Fotouhi, N.; Nuermberger, E.; Hawryluk, N.

10.1101/2021.02.10.430715 — pathology — Posted on 2021-02-12

2492 Latrophilin GPCR Signaling Mediates Synapse Formation

Sando, R.; Südhof, T. C.

10.1101/2021.02.10.430631 — cell biology — Posted on 2021-02-12

2493 Brain deletion of Serf2 shifts amyloid conformation in a mouse model

Stroo, E.; Janssen, L.; Sin, O.; Hogewerf, W.; Koster, M. H.; Harkema, L.; Youssef, S. A.; beschorner, N.; Wolters, A. H. G.; Bakker, B.; Thathiah, A.; Foijer, F.; van de Sluis, B.; van Deursen, J.; Jucker, M.; de Bruin, A.; Nollen, E.

10.1101/2021.01.05.423442 — molecular biology — Posted on 2021-02-12

2494 The Landscape of Precision Cancer Combination Therapy: A Single-Cell Perspective

Ahmadi, S.; Sukprasert, P.; Vegesna, R.; Sinha, S.; Schischlik, F.; Artzi, N.; Khuller, S.; Schaffer, A. A.; Ruppin, E.

10.1101/2020.01.28.923532 — bioinformatics — Posted on 2021-02-12

2495 Molecular basis for gating and regulation of cardiac ryanodine receptor: underlying mechanisms for gain- and loss-of function mutations

Kobayashi, T.; Tsutsumi, A.; Kurebayashi, N.; Saito, K.; Kodama, M.; Sakurai, T.; Kikkawa, M.; Murayama, T.; Ogawa, H.

10.1101/2020.11.30.401026 — biochemistry — Posted on 2021-02-12

2496 High-Resolution Chemical Mapping and Microbial Identification of Rhizosphere using Correlative Microscopy

Bandara, C. D.; Schimdt, M.; Davoudpour, Y.; Stryhanyuk, H.; Richnow, H. H.; Musat, N.

10.1101/2021.02.05.429689 — plant biology — Posted on 2021-02-12

2497 Arabidopsis inositol polyphosphate kinases regulate COP9 signalosome functions in phosphate-homeostasis

Walia, Y.; Kasera, M.; Ingole, K. D.; Peddiraju, S.; Roy, A.; Laha, D.; Schaaf, G.; BHATTACHARJEE, S.

10.1101/2020.10.02.323584 — plant biology — Posted on 2021-02-12

2498 The validation of new phase-dependent gait stability measures: a modelling approach

Jin, J.; Kistemaker, D.; van Dieen, J.; Daffertshofer, A.; Bruijn, S.

10.1101/2020.06.18.156950 — bioengineering — Posted on 2021-02-12

2499 Maternal Biological Age Assessed in Early Pregnancy is Associated with Gestational Age at Birth

Lancaster, E. E.; Lapato, D. M.; Jackson-Cook, C.; Strauss, J. F.; Roberson-Nay, R.; York, T. P.

10.1101/2021.01.11.425979 — genomics — Posted on 2021-02-11

2500 Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down Syndrome-related phenotypes

Lana-Elola, E.; Cater, H.; Watson-Scales, S.; Greenaway, S.; Mueller-Winkler, J.; Gibbins, D.; Nemes, M.; Slender, A.; Hough, T.; Keskivali-Bond, P.; Scudamore, C. L.; Herbert, E.; Banks, G. T.; Mobbs, H.; Canonica, T.; Tosh, J.; Noy, S.; Llorian, M.; Nolan, P. M.; Griffin, J. L.; Good, M.; Simon, M.; Mallon, A.-M.; Wells, S.; Fisher, E. M.; Tybulewicz, V. L.

10.1101/2021.02.11.430828 — genetics — Posted on 2021-02-11

2501 Otolith-based discrimination of cod ecotypes and the effect of growth rate.

Jonsson, E. P.; Jonsson, E. P.; Campana, S. E.; Solmundsson, J.; Jakobsdottir, K. B.; Bartharson, H.

10.1101/2021.02.11.430748 — ecology — Posted on 2021-02-11

2502 The same ultra-rapid parallel brain dynamics underpin the production and perception of speech.

Fairs, A.; Michelas, A.; Dufour, S.; Strijkers, K.

10.1101/2021.02.11.430723 — neuroscience — Posted on 2021-02-11

2503 Hyper-connectivity between the left motor cortex and prefrontal cortex is associated with the severity of dysfunction of the descending pain modulatory system in fibromyalgia

Caumo, W.; Oliveira Franco, A.; Fernandes, C.; Vicunha, P.; Bandeira, J.; Aratanha, M. A.; Torres, I. L.; Fregni, F.

10.1101/2021.02.11.430747 — neuroscience — Posted on 2021-02-11

2504 Retrospective Study on the Health Problems of Falcons in Al Ain, United Arab Emirates

ameni, G.; Al Hemeiri, M. A.; Arias de la Torre, A.; Mohteshamuddin, K.; Degafa, B. A.

10.1101/2021.02.11.430749 — pathology — Posted on 2021-02-11

2505 Comparative evaluation of full-length isoform quantification from RNA-Seq

Sarantopoulou, D.; Brooks, T. G.; Nayak, S.; Mrcela, A.; Lahens, N. F.; Grant, G. R. R.

10.1101/698605 — bioinformatics — Posted on 2021-02-11

2506 Moving together, foraging apart: effects of the social environment on movement-integrated habitat selection

Webber, Q. M. R.; Prokopenko, C. M.; Kingdon, K. A.; Vander Wal, E.

10.1101/2021.02.11.430740 — animal behavior and cognition — Posted on 2021-02-11

2507 Nigro-striatal dopamine activation lowers behavioral and neuronal phenotypes associated with obsessive-compulsive disorder

Casado-Sainz, A.; Gudmundsen, F.; Baerentzen, S. L.; Lange, D.; Ringsted, A.; Martinez-Tajada, I.; Medina, S.; Lee, H.; Svarer, C.; Keller, S. H.; Schain, M.; Kjaerby, C.; Fisher, P. M.; Cumming, P.; Palner, M.

10.1101/2021.02.11.430770 — neuroscience — Posted on 2021-02-11

2508 Viral evolutionary dynamics predict Influenza-Like-Illnesses in patients

Wallbank, C.; Aris-Brosou, S.

10.1101/2021.01.31.429026 — evolutionary biology — Posted on 2021-02-11

2509 The structure of the human cell cycle

Stallaert, W.; Kedziora, K. M.; Taylor, C. D.; Zikry, T. M.; Sobon, H. K.; Taylor, S. R.; Young, C. L.; Limas, J. C.; Cook, J. G.; Purvis, J. E.

10.1101/2021.02.11.430845 — cell biology — Posted on 2021-02-11

2510 Macropinosomes host TLR9 signaling and regulation of inflammatory responses in microglia

Stow, J. L.; Hung, Y.; Tuladhar, N.; Xiao, Z.-J.; Tong, S. J.; Vukovic, J.; Luo, L.; Wall, A. A.

10.1101/2021.02.11.430773 — cell biology — Posted on 2021-02-11

2511 Diet-dependent Natriuretic Peptide Receptor C expression in adipose tissue is mediated by PPARγ via long-range distal enhancers

Shi, F.; Simandi, Z.; Nagy, L.; Collins, S.

10.1101/2021.02.09.430332 — molecular biology — Posted on 2021-02-11

2512 Host-pathogen genetic interactions underlie tuberculosis susceptibility

Smith, C. M.; Baker, R. E.; Proulx, M. K.; Mishra, B. B.; Long, J. E.; Park, S. W.; Lee, H.-N.; Kiritsy, M. C.; Bellerose, M. M.; Olive, A. J.; Murphy, K. C.; Papavinasasundaram, K.; Boehm, F. J.; Reames, C. J.; Meade, R. K.; Hampton, B. K.; Linnertz, C. L.; Ehrt, S.; Schnappinger, D.; Pardo-Manuel de Villena, F.; Ferris, M. T.; Ioerger, T. R.; Sassetti, C. M.

10.1101/2020.12.01.405514 — microbiology — Posted on 2021-02-11

2513 Red Blood Cells Function as DNA Sensors

Lam, M.; Murphy, S.; Kokkinaki, D.; Venosa, A.; Sherrill-Mix, S.; Casu, C.; Rivella, S.; Weiner, A.; Park, J.; Shin, S.; Vaughan, A. E.; Hahn, B. H.; Odom John, A. R.; Meyer, N. J.; Hunter, C. A.; Worthen, G. S.; Mangalmurti, N. S.

10.1101/2021.02.11.430782 — immunology — Posted on 2021-02-11

2514 Immune deposit and vasculopathy in metabolic-active lung tissues of patients with pulmonary tuberculosis

Ma, H.; Wang, L.; Wen, Z.-L.; Chen, X.; Liu, H.; Zhang, S.; Xu, J.; Song, Y.-Z.; Wong, K.-W.

10.1101/2021.02.09.430558 — immunology — Posted on 2021-02-11

2515 Regulation of Human Neutrophil Responses to Candida albicans by Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1), CEACAM3 and CEACAM6

Klaile, E.; Prada Salcedo, J. P.; Klassert, T. E.; Besemer, M.; Bothe, A.-K.; Durotin, A.; Mueller, M. M.; Verena, V.; Luther, C.; Dittrich, M.; Singer, B. B.; Dandekar, T.; Slevogt, H.

10.1101/2021.02.11.430790 — immunology — Posted on 2021-02-11

2516 Independent population coding of the past and the present in prefrontal cortex during learning

Maggi, S.; Humphries, M. D.

10.1101/668962 — neuroscience — Posted on 2021-02-11

2517 Quantitative dialing of gene expression via precision targeting of KRAB repressor

Wilken, M. S.; Ciarlo, C.; Pearl, J.; Bloom, J.; Schanzer, E.; Liao, H.; Van Biber, B.; Queitsch, K.; Federation, A.; Acosta, R.; Vong, S.; Otterman, E.; Dunn, D.; Wang, H.; Zrazhevskey, P.; Nandakumar, V.; Bates, D.; Sandstrom, R.; Urnov, F. D.; Funnell, A.; Green, S.; Stamatoyannopoulos, J. A.

10.1101/2020.02.19.956730 — synthetic biology — Posted on 2021-02-11

2518 Root-to-shoot iron partitioning in Arabidopsis requires IRON-REGULATED TRANSPORTER1 (IRT1)

Quintana, J.; Bernal, M. I.; Scholle, M.; Holländer-Czytko, H.; Nga, N.; Piotrowski, M.; Mendoza-Cozatl, D.; Haydon, M. J.; Kraemer, U.

10.1101/2021.02.08.430285 — plant biology — Posted on 2021-02-11

2519 A versatile Tn7 transposon-based bioluminescence tagging tool for quantitative and spatial detection of bacteria in plants

Mine, A.; Matsumoto, A.; Schlueter, T.; Melkonian, K.; Takeda, A.; Nakagami, H.

10.1101/2021.02.11.430857 — plant biology — Posted on 2021-02-11

2520 Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer

Uhlitz, F.; Bischoff, P.; Peidli, S.; Sieber, A.; Obermayer, B.; Blanc, E.; Trinks, A.; Luethen, M.; Ruchiy, Y.; Sell, T.; Mamlouk, S.; Arsie, R.; Wei, T.-T.; Klotz-Noack, K.; Schwarz, R.; Sawitzki, B.; Kamphues, C.; Beule, D.; Landthaler, M.; Sers, C.; Horst, D.; Bluthgen, N.; Morkel, M.

10.1101/2020.01.10.901579 — cancer biology — Posted on 2021-02-11

2521 Identification of CRYAB+ KCNN3+ SOX9+ astro-like and EGFR+ PDGFRA+ OLIG1+ oligo-like tumoral cells in diffuse low-grade gliomas and implication of Notch1 signalling in their genesis

Augustus, M.; Pineau, D.; Aimond, F.; Azar, S.; Lecca, D.; Leventoux, N.; Scamps, F.; Muxel, S.; Darlix, A.; Ritchie, W.; Goze, C.; Rigau, V.; Duffau, H.; Hugnot, J.-P.

10.1101/2021.02.09.430313 — cancer biology — Posted on 2021-02-11

2522 Actin crosslinker competition and sorting drive emergent GUV size-dependent actin network architecture

Bashirzadeh, Y.; Redford, S. A.; Lorpaiboon, C.; Groaz, A.; Litschel, T.; Schwille, P.; Hocky, G. M.; Dinner, A.; Liu, A. P.

10.1101/2020.10.03.322354 — biophysics — Posted on 2021-02-11

2523 Mutability of mononucleotide repeats, not oxidative stress, explains the discrepancy between laboratory-accumulated mutations and the natural allele-frequency spectrum in C. elegans

Rajaei, M.; Saxena, A. S.; Johnson, L. M.; Snyder, M. C.; Crombie, T. A.; Tanny, R. E.; Andersen, E. C.; Joyner-Matos, J.; Baer, C. F.

10.1101/2021.02.09.430480 — evolutionary biology — Posted on 2021-02-11

2524 Deep learning classification of temporal data in ecology

Capinha, C.; Ceia-Hasse, A.; Kramer, A. M.; Meijer, C.

10.1101/2020.09.14.296251 — ecology — Posted on 2021-02-11

2525 Dlc1 controls cardio-vascular development downstream of Vegfa/Kdrl/Nrp1 signaling in the zebrafish embryo.

LINNERZ, T.; BERTRAND, J. Y.

10.1101/2021.02.11.430763 — developmental biology — Posted on 2021-02-11

2526 Prolonged disturbance of proteostasis induces cellular senescence via temporal mitochondrial dysfunction and enhanced mitochondrial biogenesis in human fibroblasts

Takenaka, Y.; Inoue, I.; Nakano, T.; Ikeda, M.; Kakinuma, Y.

10.1101/2020.01.22.916221 — cell biology — Posted on 2021-02-11

2527 Destabilization of the holo-DNA Polδ by loss of Pol32 confers conditional lethality that can be suppressed by stabilizing Pol31-Pol3 interaction

Shimada, K.; Tsai-Pflugfelder, M.; Davoodi Vijeh Motlagh, N.; Delgoshaie, N.; Fuchs, J. M.; Gasser, S. M.

10.1101/2021.02.11.430699 — molecular biology — Posted on 2021-02-11

2528 Mutation of lipoprotein processing pathway gene lspA or inhibition of LspA activity by globomycin increases MRSA resistance to beta-lactam antibiotics

Fingleton, C.; Zeden, M. S.; Bueno, E.; Cava, F.; O'Gara, J. P.

10.1101/2021.02.03.429649 — microbiology — Posted on 2021-02-11

2529 Small intestine lactobacilli growth promotion and immunomodulation in weaner pigs fed Cyberlindnera jadinii yeast high inclusion diet and exposed to enterotoxigenic Escherichia coli F4+: O149

Iakhno, S.; Hellestveit, S. S.; Umu, O. C. O.; Bogevik, L. T.; Akesson, C. P.; Göksu, A. B.; Press, C. M.; Mydland, L. T.; Overland, M.; Sorum, H.

10.1101/2021.02.11.430732 — microbiology — Posted on 2021-02-11

2530 Murine ex vivo cultured alveolar macrophages provide a novel tool to study tissue-resident macrophage behavior and function

Gorki, A.-D.; Symmank, D.; Zahalka, S.; Lakovits, K.; Hladik, A.; Langer, B.; Maurer, B.; Sexl, V.; Kain, R.; Knapp, S.

10.1101/2021.02.11.430791 — immunology — Posted on 2021-02-11

2531 In vivo optogenetic stimulation of the primate retina activates the visual cortex after long-term transduction

Chaffiol, A.; Provansal, M.; Joffrois, C.; Blaize, K.; Labernede, G.; Goulet, R.; Burban, E.; Brazhnikova, E.; Duebel, J.; Pouget, P.; Sahel, J.-A.; Picaud, S.; Gauvain, G.; Arcizet, F.

10.1101/2021.02.09.427243 — neuroscience — Posted on 2021-02-11

2532 Two opposite voltage-dependent currents control the unusual early development pattern of embryonic Renshaw cell electrical activity

Boeri, J.; Meunier, C.; Le Corronc, H.; Branchereau, P.; Timofeeva, Y.; Lejeune, F.-X.; Mouffle, C.; Arulkandarajah, H.; Mangin, J. M.; Legendre, P.; Czarnecki, A.

10.1101/2020.06.18.158931 — neuroscience — Posted on 2021-02-11

2533 Distinct place cell dynamics in CA1 and CA3 encode experience in new contexts

Dong, C.; Madar, A. D.; Sheffield, M.

10.1101/2020.09.10.292177 — neuroscience — Posted on 2021-02-11

2534 Predictive olfactory learning in Drosophila

Zhao, C.; Widmer, Y. F.; Diegelmann, S.; Petrovici, M. A.; Sprecher, S. G.; Senn, W.

10.1101/2019.12.29.890533 — neuroscience — Posted on 2021-02-11

2535 Cell growth model with stochastic gene expression helps understand the growth advantage of metabolic exchange and auxotrophy

Dutta, D.; Saini, S.

10.1101/2020.08.26.268771 — systems biology — Posted on 2021-02-11

2536 A burden-free gene overexpression system

Barajas, C.; Gibson, J.; Sandoval, L.; del vecchio, d.

10.1101/2021.02.11.430724 — synthetic biology — Posted on 2021-02-11

2537 Development of first linkage map for Silphium integrifolium (Asteraceae) enables identification of sporophytic self-incompatibility locus

Price, J. H.; Raduski, A. R.; Brandvain, Y.; Van Tassel, D. L.; Smith, K. P.

10.1101/2021.01.29.428840 — plant biology — Posted on 2021-02-11

2538 Constitutively enhanced genome integrity maintenance and direct stress mitigation characterize transcriptome of extreme stress-adapted Arabidopsis halleri

Lee, G.; Ahmadi, H.; Quintana, J.; Syllwasschy, L.; Janina, N.; Preite, V.; Anderson, J. E.; Pietzenuk, B.; Kraemer, U.

10.1101/859249 — plant biology — Posted on 2021-02-11

2539 Effect of using a physical assistance device for movements involving trunk bending

Jelti, Z.; Lebel, K.; Bastide, S.; Le Borgne, P.; Slangen, P.; Vignais, N.

10.1101/2021.02.08.429597 — physiology — Posted on 2021-02-11

2540 Dietary restriction in the long-chain acyl-CoA dehydrogenase knockout mouse

Diekman, E.; van Weeghel, M.; Suarez-Farinas, M.; Argmann, C.; Wanders, R.; Visser, G.; van der Made, I.; Creemers, E.; Houten, S.

10.1101/2020.12.03.408591 — physiology — Posted on 2021-02-11

2541 Immune landscape of a genetically-engineered murine model of glioma relative to human glioma by single-cell sequencing

Zamler, D. B.; Shingu, T.; Kahn, L. M.; Kassab, C.; Ott, M.; Tomczak, K.; Liu, J.; Li, Y.; Lai, I. P.; Yee, C.; Rai, K.; Heimberger, A. B.; Draetta, G.; Hu, J.

10.1101/2020.05.11.088708 — cancer biology — Posted on 2021-02-11

2542 Cytidine triphosphate promotes efficient ParB-dependent DNA condensation by facilitating one-dimensional spreading from parS

Balaguer, F. d. A.; Aicart-Ramos, C.; Fisher, G. L.; de Braganca, S.; Pastrana, C. L.; Dillingham, M. S.; Moreno-Herrero, F.

10.1101/2021.02.11.430778 — biophysics — Posted on 2021-02-11

2543 Effect of ligand sensing on flagellar bundle formation in bacteria

Agrawal, M.; Chakraborty, S.; Tirumkudulu, M. S.; Venkatesh, K. V.

10.1101/2021.02.11.430483 — biophysics — Posted on 2021-02-11

2544 Importance of viscosity contrast for the motion of erythrocytes in microcapillaries

Dasanna, A. K.; Mauer, J.; Gompper, G.; Fedosov, D.

10.1101/2021.02.11.430779 — biophysics — Posted on 2021-02-11

2545 cytoNet: Spatiotemporal Network Analysis of Cell Communities

Mahadevan, A. S.; Long, B. L.; Hu, C. W.; Ryan, D. T.; Grandel, N. E.; Maloney, Z.; Britton, G. L.; Gonzalez Porras, M. A.; Stojkova, K.; Ligeralde, A.; Son, H.; Shannonhouse, J.; Robinson, J. T.; Warmflash, A.; Brey, E.; Kim, Y. S.; Qutub, A. A.

10.1101/180273 — bioengineering — Posted on 2021-02-11

2546 Contribution of quasi-fibrillar superstructures in peroxide quenching by collagen peptides derived from fish processing by-products and their application as natural food additives

Banerjee, P.; Kadherbasha, S.; Dey, P.; Sumeet, C.; Bajaj, M.; Y, G.; A, V.; Tagadghar, P.

10.1101/2021.02.11.430827 — biochemistry — Posted on 2021-02-11

2547 Norepinephrine as a Memory Reset Signal: Switching the System from Retrieval to Encoding During a Spatial Memory Task can be Both Adaptive and Maladaptive

Grella, S. L.; Gomes, S. M.; Lackie, R. E.; Renda, B.; Marrone, D. F.

10.1101/2020.06.07.138859 — animal behavior and cognition — Posted on 2021-02-11

2548 Conditional resampling improves calibration and sensitivity in single cell CRISPR screen analysis

Katsevich, E.; Barry, T.; Roeder, K.

10.1101/2020.08.13.250092 — genomics — Posted on 2021-02-11

2549 Large palindromes on the primate X Chromosome are preserved by natural selection

Jackson, E. K.; Bellott, D. W.; Cho, T.-J.; Skaletsky, H.; Hughes, J.; Pyntikova, T.; Page, D. C.

10.1101/2020.12.29.424738 — genomics — Posted on 2021-02-11

2550 Whole plastid genome-based phylogenomics supports an inner placement of the O. insectifera group rather than a basal position in the rapidly diversifying Ophrys genus (Orchidaceae)

Bertrand, J. A. M.; Gibert, A.; Llauro, C.; Panaud, O.

10.1101/2020.12.16.423003 — evolutionary biology — Posted on 2021-02-11

2551 Fitness-related traits are maximized in recently introduced, slow-growing populations of an invasive clam: is this a response to strong r-selection?

Hünicken, L. A.; Sylvester, F.; Bonel, N.

10.1101/618082 — ecology — Posted on 2021-02-11

2552 Longitudinal analysis of the faecal microbiome in pigs fed Cyberlindnera jadinii yeast as a protein source during the weanling period followed by a rapeseed- and faba bean-based grower-finisher diet

Iakhno, S.; Delogu, F.; Umu, O. C. O.; Kjos, N. P.; Hakenasen, I. M.; Mydland, L. T.; Overland, M.; Sorum, H.

10.1101/2021.02.11.430725 — microbiology — Posted on 2021-02-11

2553 Distinct function of Mediator subunits in fungal development, stress response and secondary metabolism in fungal pathogen Fusarium verticillioides

Zhou, Z.; Yan, H.; Kim, M. S.; Shim, W. B.

10.1101/2021.02.11.430821 — microbiology — Posted on 2021-02-11

2554 CTP regulates membrane-binding activity of the nucleoid occlusion protein Noc

Jalal, A. S. B.; Tran, N. T.; Wu, L. J.; Ramakrishnan, K.; Rejzek, M.; Stevenson, C. E. M.; Lawson, D. M.; Errington, J.; Le, T. B. K.

10.1101/2021.02.11.430593 — microbiology — Posted on 2021-02-11

2555 Extracellular DNA (eDNA) enables early detection of the phenotypic switch of Pseudomonas sp. during biofilm development

Kakahi, F. B.; Kang, D.; Volke, D. C.; Wirth, N. T.; Nikel, P. I.; Delvigne, F.

10.1101/2021.02.11.430776 — microbiology — Posted on 2021-02-11

2556 Functional and taxonomic comparison of mouse and human gut microbiotas using extensive culturing and metagenomics

Beresford-Jones, B. S.; Forster, S. C.; Stares, M. D.; Notley, G.; Viciani, E.; Browne, H. P.; Kumar, N.; Vervier, K.; Almeida, A.; Lawley, T. D.; Pedicord, V. A.

10.1101/2021.02.11.430759 — microbiology — Posted on 2021-02-11

2557 Saccharomyces cerevisiae gene expression during fermentation of Pinot noir wines at industrially relevant scale

Reiter, T.; Montpetit, R.; Byer, S.; Frias, I.; Leon, E.; Viano, R.; Mcloughlin, M.; Halligan, T.; Hernandez, D.; Runnebaum, R.; Montpetit, B.

10.1101/2021.01.11.426308 — microbiology — Posted on 2021-02-11

2558 Transcriptomics provides a genetic signature of vineyard site with insight into vintage-independent regional wine characteristics

Reiter, T.; Montpetit, R.; Byer, S.; Frias, I.; Leon, E.; Viano, R.; Mcloughlin, M.; Halligan, T.; Hernandez, D.; Figueroa-Balderas, R.; Cantu, D.; Steenwerth, K.; Runnebaum, R.; Montpetit, B.

10.1101/2021.01.07.425830 — microbiology — Posted on 2021-02-11

2559 Gys1 antisense therapy rescues neuropathological bases of murine Lafora disease

Ahonen, S.; Nitschke, S.; Grossman, T. R.; Kordasiewicz, H.; Wang, P.; Zhao, X.; Guisso, D. R.; Kasiri, S.; Nitschke, F.; Minassian, B. A.

10.1101/2021.02.11.430846 — neuroscience — Posted on 2021-02-11

2560 Topography of Hippocampal Connectivity with Sensorimotor Cortex Revealed by Optimizing Smoothing Kernel and Voxel Size

Burman, D. D.

10.1101/2020.05.14.096339 — neuroscience — Posted on 2021-02-11

2561 Network dynamics underlying OFF responses in the auditory cortex

Bondanelli, G.; Deneux, T.; Bathellier, B.; Ostojic, S.

10.1101/810655 — neuroscience — Posted on 2021-02-11

2562 Non-selective response inhibition in Go/NoGo task: Bayesian analysis of fMRI data

Masharipov, R.; Kireev, M.; Korotkov, A.; Medvedev, S.

10.1101/823625 — neuroscience — Posted on 2021-02-11

2563 Emergence of task information from dynamic network interactions in the human brain

Mill, R. D.; Hamilton, J. L.; Winfield, E. C.; Lalta, N.; Chen, R. H.; Cole, M. W.

10.1101/2021.01.26.428276 — neuroscience — Posted on 2021-02-11

2564 Cortical layer-specific modulation of neuronal activity after sensory deprivation due to spinal cord injury

Zaforas, M.; Rosa, J. M.; Alonso-Calvino, E.; Fernandez-Lopez, E.; Miguel-Quesada, C.; Oliviero, A.; Aguilar, J.

10.1101/2020.12.28.424612 — neuroscience — Posted on 2021-02-11

2565 Characterization of spatial dynamics of fMRI data in white matter using diffusion-informed white matter harmonics

Behjat, H.; Aganj, I.; Abramian, D.; Eklund, A.; Westin, C.-F.

10.1101/2020.10.28.359125 — neuroscience — Posted on 2021-02-11

2566 Rubisco proton production can drive the elevation of CO2 within condensates and carboxysomes

Long, B. M.; Förster, B.; Pulsford, S. B.; Price, G. D.; Badger, M. R.

10.1101/2020.07.08.125609 — plant biology — Posted on 2021-02-11

2567 RuBisCO adaptation is more limited by phylogenetic constraint than by catalytic trade-off

Bouvier, J. W.; Emms, D. M.; Rhodes, T.; Bolton, J. S.; Brasnett, A.; Eddershaw, A.; Nielsen, J. R.; Unitt, A.; Whitney, S. M.; Kelly, S.

10.1101/2020.09.15.298075 — plant biology — Posted on 2021-02-11

2568 Crystal structure of a bacterial CNNM magnesium transporter

Chen, Y. S.; Kozlov, G.; Armitano, J.; Moeller, B. J.; Fakih, R.; Rohaim, A.; Roux, B.; Burke, J. E.; Gehring, K.

10.1101/2021.02.11.430706 — biophysics — Posted on 2021-02-11

2569 SARS-CoV-2 variants B.1.351 and B.1.1.248: Escape from therapeutic antibodies and antibodies induced by infection and vaccination

Hoffmann, M.; Arora, P.; Gross, R.; Seidel, A.; Hoernich, B.; Hahn, A.; Krueger, N.; Graichen, L.; Hofmann-Winkler, H.; Kempf, A.; Winkler, M. S.; Schulz, S.; Jaeck, H.-M.; Jahrsdoerfer, B.; Schrezenmeier, H.; Mueller, M.; Kleger, A.; Muench, J.; Poehlmann, S.

10.1101/2021.02.11.430787 — molecular biology — Posted on 2021-02-11

2570 gbpA and chiA genes are not uniformly distributed amongst diverse Vibrio cholerae

Fennell, T. G.; Blackwell, G. A.; Thomson, N. R.; Dorman, M. J.

10.1101/2021.02.11.430729 — microbiology — Posted on 2021-02-11

2571 Data-driven analysis of COVID-19 reveals specific severity patterns distinct from the temporal immune response

Lim, J.; Carissimo, G.; Chan, Y.-H.; Fong, S.-W.; Lee, W. W.; Tan, S.-Y.; Lye, D. C.; Young, B. E.; Renia, L.; Fong-Poh NG, L.; Rotzschke, O.; Puan, K. J.; Wang, L. W.; Teng, K. W. W.; Loh, C. Y.; Tan, K. P.; Poh, C. M.; Lee, C. Y.-P.; Yeo, N. K.-W.; Chee, R. S.-L.; Amrun, S. N.; Chang, Z. W.; Tay, M. Z.; Torres-Ruesta, A.; Leo Fernandez, N.; How, W.; K. Andiappan, A.; Duan, K.; Yan, G.; Kalimuddin, S.; Leo, Y.-S.; Ong, S. W. X.; Lee, B.

10.1101/2021.02.10.430668 — immunology — Posted on 2021-02-11

2572 BMP signaling interferes with optic chiasm formation and retinal ganglion cell pathfinding in zebrafish

Knickmeyer, M. D.; Mateo, J. L.; Heermann, S.

10.1101/2021.02.11.430804 — developmental biology — Posted on 2021-02-11

2573 An invariant Trypanosoma vivax vaccine antigen inducing protective immunity

Autheman, D.; Crosnier, C.; Clare, S.; Goulding, D.; Brandt, C.; Harcourt, K.; Tolley, C.; Galaway, F.; Khushu, M.; Ong, H.; Romero Ramirez, A.; Duffy, C.; Jackson, A.; Wright, G. J.

10.1101/2021.02.10.430711 — microbiology — Posted on 2021-02-11

2574 Rabies anterograde monosynaptic tracing reveals organization of spinal sensory circuits

Pimpinella, S.; Zampieri, N.

10.1101/2021.02.11.429920 — neuroscience — Posted on 2021-02-11

2575 Cholinergic calcium responses in cultured antennal lobe neurons of the migratory locust

Bergmann, G. A.; Bicker, G.

10.1101/2021.02.11.430736 — neuroscience — Posted on 2021-02-11

2576 Comprehensive imaging of synaptic activity reveals dendritic growth rules that cluster inputs

Podgorski, K.; Toth, T. D.; Coleman, P.; Opushnyev, S.; Brusco, J.; Hogg, P.; Edgcumbe, P.; Haas, K.

10.1101/2021.02.11.430646 — neuroscience — Posted on 2021-02-11

2577 Fasting reverses drug-resistance in hepatocellular carcinoma through p53-dependent metabolic synergism

10.1101/2021.02.10.430545 — cancer biology — Posted on 2021-02-11

2578 NeuronMotif: Deciphering transcriptional cis-regulatory codes from deep neural networks

Wei, Z.; Hua, K.; Wei, L.; Ma, S.; Jiang, R.; Li, Y.; Wong, W. H.; Wang, X.

10.1101/2021.02.10.430606 — bioinformatics — Posted on 2021-02-11

2579 Shared genetic underpinnings between genetic generalized epilepsy and background EEG oscillations

Stevelink, R.; Luykx, J. J.; Lin, B.; Leu, C.; Lal, D.; Smith, A.; Schijven, D.; Carpay, J.; Rademaker, K.; Baldez, R.; Braun, K.; Jansen, F.; Epi25 Collaborative, ; ILAE Consortium, ; Smit, D.; Koeleman, B.

10.1101/711200 — genetics — Posted on 2021-02-11

2580 Bacterial diversity of chronic middle ear lesions revealed by high-throughput sequencing

Gu, X.; Cheng, X.; Abulajiang, T.; Huang, X.

10.1101/2021.02.10.430714 — microbiology — Posted on 2021-02-11

2581 Action-based predictions affect visual perception, neural processing, and pupil size, regardless of temporal predictability

Lubinus, C.; Einhaeuser, W.; Schiller, F.; Kircher, T.; Straube, B.; van Kemenade, B. M.

10.1101/2021.02.11.430717 — neuroscience — Posted on 2021-02-11

2582 Optimized CRISPR tools and site-directed transgenesis in Culex quinquefasciatus mosquitoes for gene drive development.

Feng, X.; Lopez Del Amo, V.; Mameli, E.; Lee, M.; Bishop, A. L.; Perrimon, N.; Gantz, V. M.

10.1101/2021.02.10.430702 — synthetic biology — Posted on 2021-02-11

2583 The role of gene segment interactions in driving the emergence of dominant gene constellations during influenza virus reassortment

Trifkovic, S.; Gilbertson, B.; Fairmaid, E.; Cobbin, J.; Rockman, S.; Brown, L. E.

10.1101/2021.02.10.430697 — microbiology — Posted on 2021-02-11

2584 Modelling spinal locomotor circuits for movements in developing zebrafish

Roussel, Y.; Gaudreau, S. F.; Sengupta, M.; Bui, T. V.

10.1101/2021.02.10.430671 — neuroscience — Posted on 2021-02-11

2585 TemplateFlow: a community archive of imaging templates and atlases for improved consistency in neuroimaging

Ciric, R.; Lorenz, R.; Thompson, W. H.; Goncalves, M.; MacNicol, E.; Markiewicz, C.; Halchenko, Y.; Ghosh, S. S.; Gorgolewski, K. J.; Poldrack, R.; Esteban, O.

10.1101/2021.02.10.430678 — neuroscience — Posted on 2021-02-11

2586 5-hydroxymethylcytosine mediated active demethylation is required for neuronal differentiation and function

Stoyanova, E.; Riad, M.; Rao, A.; Heintz, N.

10.1101/2021.02.10.430698 — neuroscience — Posted on 2021-02-11

2587 Fixational drift is driven by diffusive dynamics in central neural circuitry

Ben-Shushan, N.; Shaham, N.; Joshua, M.; Burak, Y.

10.1101/2021.02.10.430643 — neuroscience — Posted on 2021-02-11

2588 Evaluating Wayfinding Designs in Healthcare Settings through EEG Data and Virtual Response Testing

Kalantari, S.; Tripathi, V.; Rounds, J. D.; Mostafavi, A.; Snell, R.; Cruz-Garza, J.

10.1101/2021.02.10.430638 — neuroscience — Posted on 2021-02-11

2589 Expression of a tetracycline-controlled transactivator (Tet-On/Off system) in beta cells reduces insulin expression and secretion in mice

Jouvet, N.; Bouyakdan, K.; Baldwin, C.; Marcinkiewicz, J.; Alquier, T.; Estall, J. L.

10.1101/2021.02.10.430692 — physiology — Posted on 2021-02-11

2590 Hotspot ESR1 mutations are multimodal and contextual drivers of breast cancer metastasis

Li, Z.; Wu, Y.; Yates, M. E.; Tasdemir, N.; Bahreini, A.; Chen, J.; Levine, K. M.; Priedigkeit, N. M.; Ali, S.; Buluwela, L.; Arnesen, S.; Gertz, J.; Richer, J. K.; Troness, B.; El-Ashry, D.; Zhang, Q.; Gerratana, L.; Zhang, Y.; Cristofanilli, M.; Montanez, M. A.; Sundd, P.; Wallace, C. T.; Watkins, S. C.; Zhu, L.; Tseng, G.; Wagle, N.; Carroll, J.; Jank, P.; Denkert, C.; Karsten, M. M.; Blohmer, J.; Park, B. H.; Lucas, P. C.; Atkinson, J. M.; Lee, A. V.; Oesterreich, S.

10.1101/2021.02.10.430701 — cancer biology — Posted on 2021-02-11

2591 Accelerating COVID-19 research with graph mining and transformer-based learning

Tyagin, I.; Kulshrestha, A.; Sybrandt, J.; Matta, K.; Shtutman, M.; Safro, I.

10.1101/2021.02.11.430789 — bioinformatics — Posted on 2021-02-11

2592 Prediction of adverse drug reactions associated with drug-drug interactions using hierarchical classification

Kim, C.; Tatonetti, N.

10.1101/2021.02.10.430512 — bioinformatics — Posted on 2021-02-11

2593 VIA: Generalized and scalable trajectory inference in single-cell omics data

stassen, S. V.; Yip, G.; Ho, J. W. K.; Wong, K. K. Y.; Tsia, K.

10.1101/2021.02.10.430705 — bioinformatics — Posted on 2021-02-11

2594 Niche-guided tissue patterning by chemomechanical flow lithography

Newman, P. L. H.; Osteil, P.; Anderson, T. A.; Sun, J. Q. J.; Kempe, D.; Biro, M.; Tam, P. P. L.; Shin, J.-W.; Zreiqat, H.

10.1101/2021.02.10.430691 — bioengineering — Posted on 2021-02-11

2595 A Framework for Sensor-based Assessment of Upper-limb Functioning

David, A.; Subash, T.; SKM, V.; Melendez-Calderon, A.; Balasubramanian, S.

10.1101/2021.02.10.430700 — bioengineering — Posted on 2021-02-11

2596 A system for continuous and automated measurement of mouse home-cage drinking with automated control of liquid access

Bagley, J.; Kashinsky, W. M.; Jentsch, J. D.

10.1101/2021.02.10.430693 — animal behavior and cognition — Posted on 2021-02-11

2597 Suppressing evolution through environmental switching

Morsky, B.; Vural, D.

10.1101/2021.02.10.430675 — ecology — Posted on 2021-02-11

2598 Adjuvanting a subunit SARS-CoV-2 nanoparticle vaccine to induce protective immunity in non-human primates

S Arunachalam, P.; Walls, A. C.; Golden, N.; Atyeo, C.; Fischinger, S.; Li, C.; Aye, P.; Navarro, M. J.; Lai, L.; Edara, V. V.; Roltgen, K.; Rogers, K.; Shirreff, L.; Ferrell, D. E.; Wrenn, S.; Pettie, D.; Kraft, J. C.; Miranda, M. C.; Kepl, E.; Sydeman, C.; Brunette, N.; Murphy, M.; Fiala, B.; Carter, L.; White, A. G.; Trisal, M.; Hsieh, C.-L.; Russell-Lodrigue, K.; Monjure, C.; Dufour, J.; Doyle-Meyer, L.; Bohm, R. B.; Maness, N. J.; Roy, C.; Plante, J. A.; Plante, K. S.; Zhu, A.; Gorman, M. J.; Shin, S.; Shen, X.; Fontenot, J.; Gupta, S.; O Hagan, D. T.; Most, R. V. D.; Rappuoli, R.; Coffma

10.1101/2021.02.10.430696 — immunology — Posted on 2021-02-11

2599 Differential roles of RIG-I-like receptors in SARS-CoV-2 infection

Yang, D.; Geng, T.; Harrison, A. G.; WANG, P.

10.1101/2021.02.10.430677 — immunology — Posted on 2021-02-11

2600 Specialization of actin isoforms derived from the loss of key interactions with regulatory factors

Boiero Sanders, M.; Toret, C.; Antkowiak, A.; Guillotin, A.; Robinson, R. C.; Michelot, A.

10.1101/2021.02.09.430555 — cell biology — Posted on 2021-02-11

2601 Synthetic multistability in mammalian cells

Zhu, R.; del Rio-Salgado, J. M.; Garcia-Ojalvo, J.; Elowitz, M.

10.1101/2021.02.10.430659 — synthetic biology — Posted on 2021-02-11

2602 Cutevariant: a GUI-based desktop application to explore genetics variations

Schutz, S.; Montier, T.; Genin, E.

10.1101/2021.02.10.430619 — bioinformatics — Posted on 2021-02-11

2603 Bfimpute: A Bayesian factorization method to recover single-cell RNA sequencing data

Wen, Z.-H.; Langsam, J. L.; Zhang, L.; Shen, W.; Zhou, X.

10.1101/2021.02.10.430649 — bioinformatics — Posted on 2021-02-11

2604 Gene dosage effects of polyA track engineered hypomorphs

Powell, G. N.; Pavlovic-Djuranovic, S.; Djuranovic, S.

10.1101/2021.02.10.430645 — genetics — Posted on 2021-02-11

2605 Cytogenetic events in the endosperm of amphiploid Avena maroccana x A. longiglumis

KOSINA, R.; Tomaszewska, P.

10.1101/2021.02.10.430611 — genetics — Posted on 2021-02-11

2606 Evidence of stock connectivity, hybridization and misidentification in white anglerfish support the need for adopting a genetics-informed fisheries management approach

Aguirre-Sarabia, I.; Diaz-Arce, N.; Pereda-Agirre, I.; Mendibil, I.; Urtizberea, A.; Gerritsen, H. D.; Burns, F.; Holmes, I.; Landa, J.; Coscia, I.; Quincoces, I.; Santurtun, M.; Zanzi, A.; Martinsohn, J. T.; Rodriguez-Ezpeleta, N.

10.1101/2021.02.10.430581 — evolutionary biology — Posted on 2021-02-11

2607 Effects of physical, chemical, and biological ageing on the mineralization of pine wood biochar by a Streptomyces isolate

Zeba, N.; Berry, T. D.; Whitman, T.

10.1101/2021.02.10.430652 — ecology — Posted on 2021-02-11

2608 Participant followup rate can bias structural imaging measures in longitudinal studies

Beare, R.; Yang, J. Y.-M.; Ball, G.; Moran, C.; Srikanth, V.; Seal, M.

10.1101/2021.02.10.430674 — neuroscience — Posted on 2021-02-11

2609 On the distribution of spinal premotor interneurons

Ronzano, R.; Skarlatou, S.; Bannatyne, B. A.; Bhumbra, G. S.; Foster, J. D.; Lancelin, C.; Pocratsky, A.; Ozyurt, M. G.; Smith, C. C.; Todd, A. J.; Maxwell, D. J.; Murray, A. J.; Brownstone, R. M.; Zampieri, N.; Beato, M.

10.1101/2021.02.10.430608 — neuroscience — Posted on 2021-02-11

2610 A Multiscale, Systems-level, Neuropharmacological Model of Cortico-Basal Ganglia System for Arm Reaching under Normal, Parkinsonian and Levodopa Medication Conditions

Nair, S. S.; Muddapu, V. R.; Chakravarthy, V. S.

10.1101/2021.02.10.430544 — neuroscience — Posted on 2021-02-11

2611 Cued Naming and the left inferior frontal cortex

Holland, R.; Crinion, J.

10.1101/2021.02.10.430676 — neuroscience — Posted on 2021-02-11

2612 Promises and pitfalls of Topological Data Analysis for brain connectivity analysis

Caputi, L.; Pidnebesna, A.; Hlinka, J.

10.1101/2021.02.10.430469 — neuroscience — Posted on 2021-02-11

2613 Mice Make Targeted Saccades

Zahler, S. H.; Taylor, D. E.; Adams, J. M.; Feinberg, E. H.

10.1101/2021.02.10.430669 — neuroscience — Posted on 2021-02-11

2614 Relatively Shorter Muscle Lengths Increase the Metabolic Rate of Cyclic Force Production

Beck, O. N.; Schroeder, J. N.; Trejo, L. H.; Franz, J. R.; Sawicki, G. S.

10.1101/2021.02.10.430661 — physiology — Posted on 2021-02-11

2615 A like-for-like comparison of lightweight-mapping pipelines for single-cell RNA-seq data pre-processing

Zakeri, M.; Srivastava, A.; Sarkar, H.; Patro, R.

10.1101/2021.02.10.430656 — bioinformatics — Posted on 2021-02-11

2616 Home range and movement patterns of the Andean Fox Lycalopex culpaeus (Molina 1782) in Cotopaxi National Park, Ecuador

Castellanos, A.; Castellanos, F. X.; Kays, R.; Brito, J.

10.1101/2021.02.10.430628 — animal behavior and cognition — Posted on 2021-02-11

2617 The non-linear mixed representations in somatosensory cortex support simple and complex tasks

Nogueira, R.; Rodgers, C. C.; Bruno, R. M.; Fusi, S.

10.1101/2021.02.11.430704 — neuroscience — Posted on 2021-02-11

2618 An Activator Locks Kv7.1 Channels Open by Electro-Mechanical Uncoupling and Allosterically Modulates its Pore with similarity to phosphatidylinositol-4,5-bisphosphat

Moeller, M.; Schreiber, J. A.; Zaydman, M.; Beller, Z.; Becker, S.; Ritter, N.; Wrobel, E.; Strutz-Seebohm, N.; Decher, N.; Cui, J.; Schmidt, N.; Duefer, M.; Wuensch, B.; Seebohm, G.

10.1101/2021.02.11.430741 — biophysics — Posted on 2021-02-11

2619 Human retinal organoids release extracellular vesicles that regulate gene expression in target human retinal progenitors

Zhou, J.; Flores-Bellver, M.; Pan, J.; Benito-Martin, A.; Shi, C.; Onwumere, O.; Mighty, J.; Qian, J.; Zhong, X.; Hogue, T.; Amponsah-Antwi, B.; Einbond, L.; Gharbaran, R.; Wu, H.; Chen, B.-J.; Zheng, Z.; Tchaikovskaya, T.; Zhang, X.; Peinado, H.; Canto-Soler, V.; Redenti, S.

10.1101/2021.02.10.430690 — developmental biology — Posted on 2021-02-11

2620 A strategy to address dissociation-induced compositional and transcriptional bias for single-cell analysis of the human mammary gland

Engelbrecht, L. K.; Twigger, A.-J.; Ganz, H. M.; Gabka, C. J.; Bausch, A. R.; Lickert, H.; Sterr, M.; Kunze, I.; Khaled, W. T.; Scheel, C. H.

10.1101/2021.02.11.430721 — cell biology — Posted on 2021-02-11

2621 Microtubule lattice defects promote catastrophes.

Rai, A.; Liu, T.; Katrukha, E. A.; Estevez-Gallego, J.; Paterson, I.; Diaz, F.; Kapitein, L. C.; Moores, C. A.; Akhmanova, A.

10.1101/2021.02.11.430743 — cell biology — Posted on 2021-02-11

2622 Ultra-sensitive nanoLC-MS using second generation micro pillar array LC technology with Orbitrap Exploris 480 and FAIMS PRO to enable single cell proteomics

Stejskal, K.; Op de Beeck, J.; Düernberger, G.; Jacobs, P. O.; Mechtler, K.

10.1101/2021.02.10.430648 — cell biology — Posted on 2021-02-11

2623 pH profiling of mitochondrial sub-compartments reveals that IF1 is essential to prevent ATP hydrolysis under OXPHOS conditions

Rieger, B.; Arroum, T.; Villalta, J.; Busch, K. B.

10.1101/2021.02.11.430746 — cell biology — Posted on 2021-02-11

2624 An opposing self-reinforced odor pre-exposure memory produces latent inhibition in Drosophila

Jacob, P. F.; Vargas-Gutierrez, P.; Okray, Z.; Vietti-Michelina, S.; Felsenberg, J.; Waddell, S.

10.1101/2021.02.10.430636 — neuroscience — Posted on 2021-02-11

2625 scPNMF: sparse gene encoding of single cells to facilitate gene selection for targeted gene profiling

Song, D.; Li, K. A.; Hemminger, Z.; Wollman, R.; Li, J. J.

10.1101/2021.02.09.430550 — bioinformatics — Posted on 2021-02-11

2626 CONTEXT-INDEPENDENT FUNCTION OF A CHROMATIN BOUNDARY IN VIVO

Willemin, A.; Lopez-Delisle, L.; Bolt, C. C.; Gadolini, M.-L.; Duboule, D.; Rodriguez-Carballo, E.

10.1101/2021.02.11.430727 — genetics — Posted on 2021-02-11

2627 Host-mediated, cross-generational intraspecific competition in a herbivore species

Castagneyrol, B.; van Halder, I.; Kadiri, Y.; Schille, L.; Jactel, H.

10.1101/2020.07.30.228544 — ecology — Posted on 2021-02-11

2628 How much does it take to be old? Modelling the time since the last harvesting to infer the distribution of mature forests in France

Thompson, L.; Cateau, E.; Debaive, N.; Bray, F.; Torre, A.; Vallet, P.; Paillet, Y.

10.1101/2021.02.08.430252 — ecology — Posted on 2021-02-11

2629 Mitochondrial Fission Regulates Transcription of Ribosomal Protein Genes in Embryonic Hearts

Zhao, Q.; Yan, S.; Lu, J.; Parker, D. J.; Wu, H.; Sun, Q.; Crossman, D.; Liu, S.; Wang, Q.; Sesaki, H.; Mitra, K.; Liu, K.; Jiao, K.

10.1101/2021.02.10.430627 — developmental biology — Posted on 2021-02-11

2630 ZC3H4 restricts non-coding transcription in human cells

West, S.; Estell, C.; Davidson, L.; Monier, A.; Steketee, P.

10.1101/2021.02.10.430684 — molecular biology — Posted on 2021-02-11

2631 The discriminatory power of the T cell receptor

Pettmann, J.; Huhn, A.; Abu-Shah, E.; Kutuzov, M. A.; Wilson, D. B.; Dustin, M.; Davis, S.; van der Merwe, P. A.; Dushek, O.

10.1101/2020.11.16.384495 — immunology — Posted on 2021-02-11

2632 EEG-based decoding and recognition of imagined music

Tibo, M.; Geirnaert, S.; Bertrand, A.

10.1101/2020.09.30.320176 — neuroscience — Posted on 2021-02-11

2633 Sailing in rough waters: examining volatility of fMRI noise

Leppanen, J.; Stone, H.; Lythgoe, D. J.; Williams, S.; Horvath, B.

10.1101/2020.06.19.161570 — neuroscience — Posted on 2021-02-11

2634 Multi-class Cancer Classification and Biomarker Identification using Deep Learning

Muazzam, F.

10.1101/2020.12.24.424317 — bioinformatics — Posted on 2021-02-11

2635 Creating Clear and Informative Image-based Figures for Scientific Publications

Jambor, H.; Antonietti, A.; Alicea, B. J.; Audisio, T. L.; Auer, S.; Bhardwaj, V.; Burgess, S. J.; Ferling, I.; Gazda, M. A.; Hoeppner, L. H.; Ilangovan, V.; Lo, H.; Olson, M.; Mohamed, S. Y.; Sarabipour, S.; Varma, A.; Walavalkar, K.; Wissink, E.; Weissgerber, T. L.

10.1101/2020.10.08.327718 — bioinformatics — Posted on 2021-02-11

2636 Effects of Perinatal Fluoxetine Exposure on Novelty-induced Social and Non-Social Investigation Behaviors in a Seminatural Environment

Sylte, O. C.; Johansen, J. S.; Heinla, I.; Houwing, D. J.; Olivier, J. D.; Heijkoop, R.; Snoeren, E. M.

10.1101/2021.02.09.430401 — animal behavior and cognition — Posted on 2021-02-11

2637 Natural enemies have inconsistent impacts on the coexistence of competing species

Terry, C.; Chen, J.; Lewis, O. T.

10.1101/2020.08.27.270389 — ecology — Posted on 2021-02-11

2638 Characterization and rescue by oxytocin of an atypical thermo-sensory reactivity in neonatal mice lacking the autism-associated gene Magel2.

Caccialupi Da Prato, L.; Abdallah, D.; Point, V.; Schaller, F.; Montheil, A.; Pallesi-Pocachard, E.; Canaan, S.; Gaiarsa, J.-L.; Muscatelli, F.; Matarazzo, V.

10.1101/869487 — neuroscience — Posted on 2021-02-11

2639 A comprehensive urine proteome database generated from patients with various renal conditions and prostate cancer

Swensen, A. C.; He, J.; Fang, A. C.; Ye, Y.; Nicora, C. D.; Shi, T.; Liu, A. Y.; Sigdel, T. K.; Sarwal, M. M.; QIAN, W.-J.

10.1101/2021.02.10.430660 — systems biology — Posted on 2021-02-11

2640 Identification and mechanistic analysis of an inhibitor of the CorC Mg2+ transporter

Huang, Y.; Mu, K.; Teng, X.; Zhao, Y.; Funato, Y.; Miki, H.; Zhu, W.; Xu, Z.; Hattori, M.

10.1101/2021.02.10.430528 — biophysics — Posted on 2021-02-11

2641 Electrical Unfolding of Cytochrome c During Translocation Through a Nanopore Constriction

Tripathi, P.; Benabbas, A.; Mehrafrooz, B.; Yamazaki, H.; Aksimentiev, A.; Champion, P.; Wanunu, M.

10.1101/2021.02.10.430607 — biophysics — Posted on 2021-02-11

2642 Autonomous epithelial folding induced by an intracellular mechano-polarity feedback loop

Wen, F.-L.; Kwan, C. W.; Wang, Y.-C.; Shibata, T.

10.1101/2021.02.10.430574 — biophysics — Posted on 2021-02-11

2643 A rationally designed c-di-AMP FRET biosensor to monitor nucleotide dynamics

Pollock, A. J.; Choi, P. H.; Zaver, S. A.; Tong, L.; Woodward, J. J.

10.1101/2021.02.10.430713 — bioengineering — Posted on 2021-02-11

2644 Computational Simulation of 4-D Micro-Circular Network in Zebrafish Tail Amputation and Regeneration

Roustaei, M.; Baek, K. I.; Wang, Z.; Cavallero, S.; Satta, S.; Lai, A.; O'Donnell, R.; Vedula, V.; Ding, Y.; Marsden, A. L.; Hsiai, T.

10.1101/2021.02.10.430654 — bioengineering — Posted on 2021-02-11

2645 Comparative proteome signatures of ultra-low input samples by TMT multiplexed Data-Independent Acquisition

Ctortecka, C.; Krssakova, G.; Stejskal, K.; Penninger, J.; Mendjan, S.; Mechtler, K.; Stadlmann, J.

10.1101/2021.02.11.430601 — biochemistry — Posted on 2021-02-11

2646 Rapid genomic convergent evolution in experimental populations of Trinidadian guppies (Poecilia reticulata)

van der Zee, M. J.; Whiting, J. R.; Paris, J. R.; Bassar, R. D.; Travis, J.; Weigel, D.; Reznick, D. N.; Fraser, B. A.

10.1101/2021.02.10.430609 — evolutionary biology — Posted on 2021-02-11

2647 A molecular framework for control of oriented cell division in the Arabidopsis embryo

Vaddepalli, P.; de Zeeuw, T.; Strauss, S.; Buerstenbinder, K.; Liao, C.-Y.; Smith, R.; Weijers, D.

10.1101/2021.02.09.430440 — plant biology — Posted on 2021-02-11

2648 Characterisation of immune cell subsets of tumour infiltrating lymphocytes in brain metastases

Kalita-de Croft, P.; Chittoory, H.; Nguyen, T.; Saunus, J. M.; Gyeong Kim, W.; McCart Reed, A.; Lim, M.; De Luca, X. M.; Ferguson, K.; Niland, C.; Mazzieri, R.; Dolcetti, R.; Simpson, P. T.; Lakhani, S. R.

10.1101/2021.02.10.430531 — pathology — Posted on 2021-02-11

2649 Multiplatform Computational Analysis of Mast Cells in Adrenocortical Carcinoma Tumor Microenvironment

Baechle, J. J.; Hanna, D. N.; Konjeti, S. R.; Rathmell, J. C.; Rathmell, W. K.; Baregamian, N.

10.1101/2021.02.09.430462 — cancer biology — Posted on 2021-02-11

2650 Genome-wide prediction and integrative functional characterization of Alzheimer's disease-associated genes

Lin, C.; Li, H.-D.; Deng, C.; Liu, W.; Erhardt, S.; WU, F.; Zhao, X.; Wang, J.; Wang, D.; Hu, B.; Wang, J.

10.1101/2021.02.09.430536 — bioinformatics — Posted on 2021-02-10

2651 Accommodating site variation in neuroimaging data using hierarchical and Bayesian models

Bayer, J. M. M.; Dinga, R.; Kia, S. M.; Kottaram, A. R.; Wolfers, T.; Lv, J.; Zalesky, A.; Schmaal, L.; Marquand, A.

10.1101/2021.02.09.430363 — bioinformatics — Posted on 2021-02-11

2652 Sequence neighborhoods enable reliable prediction of pathogenic mutations in cancer genomes

Banerjee, S.; Raman, K.; Ravindran, B.

10.1101/2021.02.09.430460 — bioinformatics — Posted on 2021-02-11

2653 An integrated strategy reveals complex glycosylation of erythropoietin using top-down and bottom-up mass spectrometry

Guan, Y.; Zhang, M.; Gaikwad, M.; Voss, H.; Fazel, R.; Ansari, S.; Shen, H.; Wang, J.; Hartmut, S.

10.1101/2021.02.09.430553 — biochemistry — Posted on 2021-02-10

2654 Proteomics reveals commitment to germination in barley seeds is marked by loss of stress response proteins and mobilisation of nutrient reservoirs

Osama, S. K.; Kerr, E. D.; Yousif, A. M.; Phung, T. K.; Kelly, A. M.; Fox, G. P.; Schulz, B. L.

10.1101/2020.06.02.130823 — biochemistry — Posted on 2021-02-11

2655 CRISPR perturbations at many coronary artery disease loci impair vascular endothelial cell functions

Wünnemann, F.; Fotsing Tadjo, T.; Beaudoin, M.; Lalonde, S.; Sin Lo, K.; Lettre, G.

10.1101/2021.02.10.430527 — genomics — Posted on 2021-02-11

2656 Detecting de novo mitochondrial mutations in angiosperms with highly divergent evolutionary rates

Broz, A. K.; Waneka, G.; Wu, Z.; Fernandes Gyorfy, M.; Sloan, D. B.

10.1101/2020.12.09.418582 — genetics — Posted on 2021-02-11

2657 The UCR Minicore: a valuable resource for cowpea research and breeding

Munoz-Amatriain, M.; Lo, S.; Herniter, I. A.; Boukar, O.; Fatokun, C.; Carvalho, M.; Castro, I.; Guo, Y.-N.; Huynh, B.-L.; Roberts, P. A.; Carnide, V.; Close, T. J.

10.1101/2021.02.09.430326 — genetics — Posted on 2021-02-11

2658 Beyond fitness: selection and information flow through the constructive steps in lifecycles

Smith, E.

10.1101/2021.02.09.430402 — evolutionary biology — Posted on 2021-02-10

2659 Desert lizard diversity worldwide: effects of environment, time, and evolutionary rate

Tejero-Cicuendez, H.; Tarroso, P.; Carranza, S.; Rabosky, D.

10.1101/2021.02.09.430433 — evolutionary biology — Posted on 2021-02-10

2660 Mutability of mononucleotide repeats, not oxidative stress, explains the discrepancy between laboratory-accumulated mutations and the natural allele-frequency spectrum in C. elegans

Rajaei, M.; Saxena, A. S.; Johnson, L. M.; Snyder, M. C.; Crombie, T. A.; Tanny, R. E.; Andersen, E. C.; Joyner-Matos, J.; Baer, C. F.

10.1101/2021.02.09.430480 — evolutionary biology — Posted on 2021-02-10

2661 Stochastic effects on the establishment of mutants resistant to β-lactam antibiotics

Saebelfeld, M.; Das, S. G.; Hagenbeek, A.; Krug, J.; de Visser, A.

10.1101/2021.02.09.430436 — evolutionary biology — Posted on 2021-02-11

2662 Genome resequencing reveals rapid, repeated evolution in the Colorado potato beetle, Leptinotarsa decemlineata

Pelissie, B.; Chen, Y. H.; Cohen, Z. P.; Crossley, M. S.; Hawthorne, D.; Schoville, S. D.

10.1101/2021.02.09.430453 — evolutionary biology — Posted on 2021-02-11

2663 Validating a high-throughput tracking system: ATLAS as a regional-scale alternative to GPS

Beardsworth, C. E.; Gobbens, E.; van Maarseveen, F.; Denissen, B.; Dekinga, A.; Nathan, R.; Toledo, S.; Bijleveld, A. I.

10.1101/2021.02.09.430514 — ecology — Posted on 2021-02-10

2664 Ectomycorrhizas accelerate decomposition to a greater extent than arbuscular mycorrhizas in a northern deciduous forest

Carteron, A.; Cichonski, F.; Laliberte, E.

10.1101/2021.02.09.430490 — ecology — Posted on 2021-02-10

2665 Nanocharacterisation of extracellular vesicles uncovers the correlation between isolation methods, physicochemical composition and their biological function

10.1101/2021.02.09.430523 — cell biology — Posted on 2021-02-10

2666 Sub-diffraction error mapping for localization microscopy images

Marsh, R. J.; Costello, I.; Gorey, M.-A.; Ma, D.; Huang, F.; Gautel, M.; Parsons, M.; Cox, S.

10.1101/2021.02.10.427128 — cell biology — Posted on 2021-02-10

2667 A systematic analysis of Trypanosoma brucei chromatin factors identifies novel protein interaction networks associated with sites of transcription initiation and termination

Staneva, D. P.; Carloni, R.; Auchynnikava, T.; Tong, P.; Arulanandam, J. A.; Rappsilber, J.; Matthews, K. R.; Allshire, R.

10.1101/2021.02.09.430399 — molecular biology — Posted on 2021-02-10

2668 Joint language production: an electrophysiological investigation of simulated lexical access on behalf of task partner

Kuhlen, A. K.; Abdel Rahman, R.

10.1101/2020.09.18.303099 — neuroscience — Posted on 2021-02-10

2669 Detection of Plasmodium sporozoites in Anopheles coustani s.l; a hindrance to malaria control strategies in highlands of western Kenya

Omukunda, E. N.; Ayuya, S.; Kitungulu, N. N.; Webale, M. K.; Busula, A.

10.1101/2021.02.10.430589 — zoology — Posted on 2021-02-10

2670 Consequences of pharmacophagous uptake from plants and conspecifics in a sawfly elucidated using chemical and molecular techniques

Paul, S. C.; Dennis, A. B.; Tewes, L. J.; Friedrichs, J.; Mueller, C.

10.1101/2021.02.09.430406 — zoology — Posted on 2021-02-10

2671 Oncogenic alterations in the p53 pathway abolish oscillatory competence

Xiong, L.; Garfinkel, A.

10.1101/2021.02.09.430245 — systems biology — Posted on 2021-02-10

2672 Scaling laws in enzyme function reveal a new kind of biochemical universality

Gagler, D.; Karas, B.; Kempes, C. P.; Goldman, A.; Kim, H.; Walker, S.

10.1101/2021.02.09.430541 — systems biology — Posted on 2021-02-10

2673 Change in protein, oil and fatty acid contents in soybeans (Glycine max (L.) Merr.) of different seed coat colors and seed weight

Choi, Y.-M.; Yoon, H.; Shin, M.-J.; Lee, Y.; Hur, O. S.; Lee, B. C.; Ha, B.-K.; Wang, X.; Desta, K. T.

10.1101/2021.02.10.430590 — plant biology — Posted on 2021-02-10

2674 Abscisic-acid-dependent regulation of Arabidopsis thaliana ammonium transport relies on ABI1 control of CIPK23 and AMT1

Ganz, P.; Porras-Murillo, R.; Ijato, T.; Menz, J.; Straub, T.; Stuehrwohldt, N.; Moradtalab, N.; Ludewig, U.; Neuhaeuser, B.

10.1101/2021.02.09.430435 — plant biology — Posted on 2021-02-10

2675 Up-regulation of bundle sheath electron transport capacity under limiting light in C4 Setaria viridis

Ermakova, M.; Bellasio, C.; Fitzpatrick, D.; Furbank, R. T.; Mamedov, F.; von Caemmerer, S.

10.1101/2021.02.10.430537 — plant biology — Posted on 2021-02-10

2676 A Unit Pipe Pneumatic model to simulate gas kinetics during measurements of embolism in excised angiosperm xylem

Yang, D.; Pereira, L.; Peng, G.; Ribeiro, R.; Kaack, L.; Jansen, S.; Tyree, M. T.

10.1101/2021.02.09.430450 — plant biology — Posted on 2021-02-10

2677 In vitro evaluation of grapevine endophytes, epiphytes and sap micro-organisms for potential use to control grapevine trunk disease pathogens.

Blundell, R.; Arreguin, M.; Eskalen, A.

10.1101/2021.02.09.430335 — plant biology — Posted on 2021-02-10

2678 The seasonal dynamics of bud dormancy in grapevine suggest a regulated checkpoint prior to acclimation

Velappan, Y.; Chabikwa, T. G.; Considine, J. A.; Agudelo-Romero, P.; Foyer, C. H.; Signorelli, S.; Considine, M. J.

10.1101/2021.02.09.430520 — plant biology — Posted on 2021-02-10

2679 The climate benefits of yield increases in genetically engineered crops

Kovak, E. E.; Qaim, M.; Blaustein-Rejto, D.

10.1101/2021.02.10.430488 — plant biology — Posted on 2021-02-10

2680 Tandem mass spectrum similarity-based network analysis using 13C-labeled and non-labeled metabolome data to identify the biosynthesis pathway of the blood pressure-lowering asparagus metabolite asparaptine A

Nakabayashi, R.; Yamada, Y.; Nishizawa, T.; Mori, T.; Asano, T.; Kuwabara, M.; Saito, K.

10.1101/2021.02.09.430543 — plant biology — Posted on 2021-02-10

2681 Development of a Triazolobenzodiazepine-Based PET Probe for Subtype-Selective Vasopressin 1A Receptor Imaging

Haider, A.; Xiao, Z.; Xia, X.; Chen, J.; Van, R. S.; Kuang, S.; Zhao, C.; Rong, J.; Shao, T.; Ramesh, P.; Aravind, A.; Shao, Y.; Ran, C.; Young, L.; Liang, S. H.

10.1101/2021.02.09.430516 — pharmacology and toxicology — Posted on 2021-02-10

2682 Prediction of occult tumor progression via platelet RNAs in a mouse melanoma model: a potential new platform of cancer screening for early detection of cancer

Yin, Y.; Jiang, R.; Shen, M.; Li, Z.; Yan, N.; Feng, J.; Jiang, H.; Lv, J.; Shi, L.; Wang, L.; Liu, X.; Zhang, K.; Chen, D.

10.1101/2021.02.09.430530 — cancer biology — Posted on 2021-02-10

2683 Signaling amplitude molds the Ras mutation tropism of urethane

Counter, C.; Li, s.

10.1101/2021.02.09.430515 — cancer biology — Posted on 2021-02-10

2684 In-silico Structural and Molecular Docking-Based Drug Discovery Against Viral Protein (VP35) of Marburg Virus: A potent Agent of MAVD

Quazi, S.; Malik, J.; Capuzzo, A. M.; Suman, K. S.; Haider, Z.

10.1101/2021.02.09.430405 — bioinformatics — Posted on 2021-02-10

2685 Genome Warehouse: A Public Repository Housing Genome-scale Data

Chen, M.; Ma, Y.; Wu, S.; Zheng, X.; Kang, H.; Sang, J.; Xu, X.; Hao, L.; Li, Z.; Gong, Z.; Xiao, J.; Zhang, Z.; Zhao, W.; Bao, Y.

10.1101/2021.02.10.430367 — bioinformatics — Posted on 2021-02-10

2686 scPNMF: sparse gene encoding of single cells to facilitate gene selection for targeted gene profiling

Song, D.; Li, K. A.; Li, J. J.

10.1101/2021.02.09.430550 — bioinformatics — Posted on 2021-02-10

2687 Reconciling Inherent Interfacial Compatibility Conflict Enhances Adhesive Infiltration and Resolves Dentin Bonding Durability

Luo, Q.; Chen, Y.; Xu, J.; Shu, C.; Li, Z.; Zhu, W.; Shen, Y.; Li, X.

10.1101/2021.02.09.430396 — bioengineering — Posted on 2021-02-10

2688 Generating controlled gusts using vortex rings

Gupta, D.; Sane, S. P.; Arakeri, J.

10.1101/2021.02.09.430493 — bioengineering — Posted on 2021-02-10

2689 Effects of Perinatal Fluoxetine Exposure on Novelty-induced Social and Non-Social Investigation Behaviors in a Seminatural Environment

Sylte, O. C.; Johansen, J. S.; Heinla, I.; Houwing, D. J.; Heijkoop, R.; Snoeren, E. M.; Olivier, J. D.

10.1101/2021.02.09.430401 — animal behavior and cognition — Posted on 2021-02-10

2690 Comprehensive Analysis of Ubiquitously Expressed Genes in Human, From a Data-Driven Perspective

Gu, J.; Dai, J.; Lu, H.; Zhao, H.

10.1101/2021.02.09.430465 — genomics — Posted on 2021-02-10

2691 DROP: Molecular voucher database for identification of Drosophila parasitoids

Lue, C.-H.; Buffington, M. L.; Scheffer, S.; Lewis, M.; Elliott, T. A.; Lindsey, A. R. I.; Driskell, A.; Jandova, A.; Kimura, M. T.; Carton, Y.; Kula, R. R.; Schlenke, T. A.; Mateos, M.; Govind, S.; Varaldi, J.; Guerrier, E.; Giorgini, M.; Wang, X.; Hoelmer, K.; Daane, K. M.; Abram, P. K.; Pardikes, N. A.; Brown, J. J.; THIERRY, M.; Poirie, M.; Goldstein, P.; Miller, S. E.; Tracey, D.; Davis, J. S.; Jiggins, F. M.; Wertheim, B.; Lewis, O.; Leips, J.; Staniczenko, P. P. A.; Hrcek, J.

10.1101/2021.02.09.430471 — genomics — Posted on 2021-02-10

2692 Identifying the genetic basis and molecular mechanisms underlying phenotypic correlation between complex human traits using a gene-based approach

Gu, J.; Fuller, C. K.; Zheng, J.; Li, H.

10.1101/2021.02.09.430368 — genetics — Posted on 2021-02-10

2693 Glycan-Based Shaping Of The Microbiota During Primate Evolution

Singh, S.; Bastos-Amador, P.; Thompson, J. A.; Truglio, M.; Yilmaz, B.; Cardoso, S.; Sobral, D.; Soares, M. P.

10.1101/2021.02.10.430443 — evolutionary biology — Posted on 2021-02-10

2694 Testing potential mechanisms of conspecific sperm precedence in Drosophila pseudoobscura

Peckenpaugh, B.; Castillo, D. M.; Moyle, L. C.

10.1101/2021.02.09.430534 — evolutionary biology — Posted on 2021-02-10

2695 A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.

Hendrickx, F.; De Corte, Z.; Sonet, G.; Van Belleghem, S. M.; Kostlbacher, S.; Vangestel, C.

10.1101/2021.02.09.430505 — evolutionary biology — Posted on 2021-02-10

2696 The asgardarchaeal-unique contribution to protein families of the eukaryotic common ancestor was 0.3%

Knopp, M.; Stockhorst, S.; van der Giezen, M.; Garg, S. G.; Gould, S. B.

10.1101/2021.02.09.430432 — evolutionary biology — Posted on 2021-02-10

2697 Proxy-based model to assess the relative contribution of ballast water and biofoulings potential propagule pressure and prioritize vessel inspections

Ceballos Osuna, L.; Scianni, C.; Falkner, M. B.; Nedelcheva, R.; Miller, W.

10.1101/2021.02.10.430588 — ecology — Posted on 2021-02-10

2698 rasterdiv - an Information Theory tailored R package for measuring ecosystem heterogeneity from space: to the origin and back

Rocchini, D.; Thouverai, E.; Marcantonio, M.; Iannacito, M.; Da Re, D.; Torresani, M.; Bacaro, G.; Bazzichetto, M.; Bernard, A.; Foody, G. M.; Furrer, R.; Kleijn, D.; Larsen, S.; Lenoir, J.; Malavasi, M.; Marchetto, E.; Messori, F.; Montaghi, A.; Moudry, V.; Naimi, B.; Ricotta, C.; Rossini, M.; Santi, F.; Santos, M. J.; Schaepman, M.; Schneider, F.; Schuh, L.; Silvestri, S.; Simova, P.; Skidmore, A. K.; Tattoni, C.; Tordoni, E.; Vicario, S.; Zannini, P.; Wegmann, M.

10.1101/2021.02.09.430391 — ecology — Posted on 2021-02-10

2699 Mosquitoes (Diptera: Culicidae) of Ecuador: A revised checklist, new records and species of medical importance.

Ponce, P.; Cevallos, V.; Carrazco-Montalvo, A.

10.1101/2021.02.10.429771 — ecology — Posted on 2021-02-10

2700 Single paternal Dexamethasone challenge programs offspring metabolism and reveals circRNAs as novel candidates in RNA-mediated inheritance

Gapp, K.; Parada, G. E.; Gross, F.; Corcoba, A.; Grau, E.; Hemberg, M.; Bohacek, J.; Miska, E. A.

10.1101/2021.02.10.429888 — developmental biology — Posted on 2021-02-10

2701 The biogenesis and function of nucleosome arrays

Singh, A. K.; Schauer, T.; Pfaller, L.; Straub, T.; Mueller-Planitz, F.

10.1101/2021.02.10.429500 — molecular biology — Posted on 2021-02-10

2702 Fluctuations in TCR and pMHC interactions regulate T cell activation

Egan, J. R.; Elliott, T.; MacArthur, B.

10.1101/2021.02.09.430441 — immunology — Posted on 2021-02-10

2703 The integration of continuous audio and visual speech in a cocktail-party environment depends on attention

Ahmed, F.; Nidiffer, A. R.; O'Sullivan, A. E.; Zuk, N. J.; Lalor, E. C.

10.1101/2021.02.10.430634 — neuroscience — Posted on 2021-02-10

2704 Connectivity patterns shape sensory representation in a cerebellum-like network

Zavitz, D.; Amematsro, E.; Borisyuk, A.; Caron, S. J. C.

10.1101/2021.02.10.430647 — neuroscience — Posted on 2021-02-10

2705 Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenic lineages

Redmond, S. A.; Cebrian Silla, A.; Assis Nascimento, M.; Mansky, B.; Wu, D.; Obernier, K.; Romero Rodriguez, R.; Lim, D. A.; Alvarez-Buylla, A.

10.1101/2021.02.10.430525 — neuroscience — Posted on 2021-02-10

2706 An endogenous opioid circuit determines state-dependent appetitive behavior

Castro, D. C.; Oswell, C. S.; Zhang, E. T.; Pedersen, C. E.; Piantadosi, S. C.; Rossi, M. A.; Hunker, A.; Guglin, A.; Moron, J. A.; Zweifel, L. S.; Stuber, G. D.; Bruchas, M. R.

10.1101/2021.02.10.430657 — neuroscience — Posted on 2021-02-10

2707 Effects of Intravenous Magnesium Sulfate on Calcium-Regulating Hormones, Plasma and Urinary Electrolytes in Healthy Horses

Schumacher, S. A.; Kamr, A. M.; Lakritz, J.; Burns, T. A.; Bertone, A. L.; Toribio, R.

10.1101/2021.02.10.430592 — physiology — Posted on 2021-02-10

2708 Vocal plasticity in harbour seal pups

Torres Borda, L.; Jadoul, Y.; Rasilo, H.; Salazar Casals, A.; Ravignani, A.

10.1101/2021.02.10.430617 — animal behavior and cognition — Posted on 2021-02-10

2709 Genome-Wide Identification of 5-Methylcytosine Sites in Bacterial Genomes By High-Throughput Sequencing of MspJI Restriction Fragments

Anton, B. P.; Fomenkov, A.; Wu, V.; Roberts, R. J.

10.1101/2021.02.10.430591 — genomics — Posted on 2021-02-10

2710 Neuroprotective and Mitoprotective Effects of Lemon IntegroPectin on SH-SY5Y Cells

Nuzzo, D.; Picone, P.; Giardina, C.; Scordino, M.; Mudo', G.; Pagliaro, M.; Scurria, A.; Meneguzzo, F.; Ilharco, L. M.; Fidalgo, A.; Presentato, A.; Alduina, R. V.; Ciriminna, R.; Di Liberto, V.

10.1101/2021.02.09.430380 — neuroscience — Posted on 2021-02-10

2711 Emergent Oscillation Induced by Nutrient-Modulating Growth Feedback

Melendez-Alvarez, J.; He, C.; Zhang, R.; Kuang, Y.; Tian, X.-J.

10.1101/2021.02.09.430447 — synthetic biology — Posted on 2021-02-10

2712 The Asian gypsy moth (Lymantria dispar L.) populations: resistance of eggs to extreme winter temperatures

Ananko, G. G.; Kolosov, A. V.

10.1101/2021.02.09.430420 — physiology — Posted on 2021-02-10

2713 Full assembly of HIV-1 particles requires assistance of the membrane curvature factor IRSp53.

Inamdar, K.; Tsai, F.-C.; dePoret, A.; Dibsy, R.; Manzi, J.; Merida, P.; Muller, R.; Lappalainen, P.; Roingeard, P.; Mak, J.; Bassereau, P.; Favard, C.; MURIAUX, D.

10.1101/2021.02.10.430663 — biophysics — Posted on 2021-02-10

2714 Structural variants in Chinese population and their impact on phenotypes, diseases and population adaptation

Wu, Z.; Jiang, Z.; Li, T.; Xie, C.; Zhao, L.; Yang, j.; Ouyang, S.; Liu, Y.; Li, T.; Xie, Z.

10.1101/2021.02.09.430378 — genetics — Posted on 2021-02-10

2715 Role of GM-CSF in regulating metabolism and mitochondrial functions critical to macrophage proliferation

Wessendarp, M.; Watanabe, M.; Liu, S.; Stankiewicz, T.; Ma, Y.; Shima, K.; Chalk, C.; Carey, B.; Romick-Rosendale, L.; Filippi, M.-D.; Arumugam, P.

10.1101/2021.02.10.430444 — cell biology — Posted on 2021-02-10

2716 Transgenerational Regulation of Sexual Attractiveness in C. elegans Nematodes

Toker, I. A.; Lev, I.; Mor, Y.; Gurevich, Y.; Fisher, D.; Houri-Zeevi, L.; Antonova, O.; Hadany, L.; Shaham, S.; Rechavi, O.

10.1101/2020.11.18.389387 — molecular biology — Posted on 2021-02-10

2717 Type IV pili share a conserved mechanism of motor-independent retraction that is an inherent property of the pilus filament

Chlebek, J. L.; Craig, L.; Dalia, A. B.

10.1101/2021.02.10.430637 — microbiology — Posted on 2021-02-10

2718 Co-culturing Hyphomicrobium nitrativorans strain NL23 and Methylophaga nitratireducenticrescens strain JAM1 allows sustainable denitrifying activities under marine conditions

Cucaita, A.; Piochon, M.; Villemur, R.

10.1101/2021.02.10.430622 — microbiology — Posted on 2021-02-10

2719 Host tropism determination by convergent evolution of immunological evasion in the Lyme disease system

Hart, T. M.; Dupuis, A. P.; Tufts, D. M.; Blom, A. M.; Starkey, S.; Rego, R. O. M.; Ram, S.; Kraiczy, P.; Kramer, L. D.; Diuk-Wasser, M. A.; Kolokotronis, S.-O.; Lin, Y.-P.

10.1101/2021.02.09.430532 — microbiology — Posted on 2021-02-10

2720 T cell derived HB-EGF prevents Th17 cell differentiation in an autocrine way.

Zaiss, D. M. W.; Macdonald, F.; van Loosdregt, J.

10.1101/2021.02.09.430418 — immunology — Posted on 2021-02-10

2721 An endogenous basis for synchronization manners of the circadian rhythm in proliferating Lemna minor plants

Ueno, K.; Ito, S.; Oyama, T.

10.1101/2021.02.09.430421 — plant biology — Posted on 2021-02-10

2722 A new variant of ASIC2 mediates sodium retention in nephrotic syndrome

Fila, M.; Sassi, A.; Brideau, G.; Morla, L.; Houillier, P.; Walter, C.; Gennaoui, M.; Collignon, L.; Keck, M.; Planelles, G.; Bakouh, N.; Peuchmaur, M.; Deschenes, G.; Anegon, I.; Remy, S.; Vogt, B.; Crambert, G.; Doucet, A.

10.1101/2021.02.09.430231 — pathology — Posted on 2021-02-10

2723 The 3-D structure of fibrous material is fully restorable from its X-ray diffraction pattern

Iwamoto, H.

10.1101/2021.02.09.430379 — biophysics — Posted on 2021-02-10

2724 "Single-subject studies"-derived analyses unveil altered biomechanisms between very small cohorts: implications for rare diseases

Aberasturi, D.; Pouladi, N.; Rachid Zaim, S.; Kenost, C.; Berghout, J.; Piegorsch, W. W.; Lussier, Y. A.

10.1101/2021.02.10.430623 — bioinformatics — Posted on 2021-02-10

2725 Modeling changes in vascular and extracellular matrix integrity that can occur in decellularized kidneys after implantation

Corridon, P. R.

10.1101/2021.02.09.430397 — bioengineering — Posted on 2021-02-10

2726 Protomer alignment modulates specificity of RNA substrate recognition by Ire1

Li, W.; Crotty, K.; Ruiz, D. G.; Voorhies, M.; Rivera, C.; Sil, A.; Mullins, D.; Jacobson, M.; Peschek, J.; Walter, P.

10.1101/2021.02.10.430655 — biochemistry — Posted on 2021-02-10

2727 N-glycosylation on Oryza Sativa Root Germin-like Protein 1 is conserved but not required for stability or activity

Rubbab, T.; Pegg, C. L.; Phung, T. K.; Nouwens, A. S.; Yeo, B. K. Y.; Zacchi, L. F.; Muhammad, A.; Naqvi, S. M. S. S.; Schulz, B. L.

10.1101/2021.02.09.430526 — biochemistry — Posted on 2021-02-10

2728 Succinate is Broadly Tissue-Permeant and Uncouples Mitochondrial Respiration from ATP Synthesis

Hass, D. T.; Robbings, B. M.; Bisbach, C. M.; Giering, E.; Mundinger, T. O.; Sadilek, M.; Sweet, I. R.; Hurley, J. B.

10.1101/2021.02.10.430650 — biochemistry — Posted on 2021-02-10

2729 Comparative analysis of mammal genomes unveils key genomic variability for human lifespan.

Farre, X.; Molina, R.; Barteri, F.; Timmers, P.; Joshi, P.; Oliva, B.; Acosta, S.; Esteve-Altava, B.; Navarro, A.; Muntane, G.

10.1101/2021.02.09.430384 — genomics — Posted on 2021-02-10

2730 Shadow ORFs illuminated: long overlapping genes in Pseudomonas aeruginosa are translated and under purifying selection

Kreitmeier, M.; Ardern, Z.; Abele, M.; Ludwig, C.; Scherer, S.; Neuhaus, K.

10.1101/2021.02.09.430400 — evolutionary biology — Posted on 2021-02-10

2731 Differential gene regulation in DAPT-treated Hydra reveals molecular pathways dependent on Notch signalling during interstitial cell differentiation and formation of the oral-aboral axis in Hydra.

Böttger, A.; Moneer, J.; Siebert, S.; Krebs, S.; Cazet, J.; Prexl, A.; Pan, Q.; Juliano, C.

10.1101/2021.02.09.430419 — developmental biology — Posted on 2021-02-10

2732 Identification and Evaluation of a Panel of Strong Constitutive Promoters in Listeria monocytogenes for Improving the Expression of Foreign Antigens

Ma, J.; Ji, Q.; Wang, S.; Qiu, J.; Liu, Q.

10.1101/2021.02.09.430548 — microbiology — Posted on 2021-02-10

2733 Capsule protects against intracellular killing and enables vascular endothelial cell translocation during invasive pneumococcal disease

Brissac, T.; Martinez, E.; Kruckow, K. L.; Riegler, A. N.; Ganaie, F.; Im, H.; Bakshi, S.; Arroyo-Diaz, N. M.; Spencer, B.; Saad, J. S.; Nahm, M. H.; Orihuela, C. J.

10.1101/2021.02.10.430484 — microbiology — Posted on 2021-02-10

2734 Soil Microbial Composition and Structure Allow Assessment of Biological Product Effectiveness and Crop Yield Prediction

Imam, N.; Belda, I.; Duehl, A. J.; Doroghazi, J. R.; Almonacid, D. E.; Thomas, V. P.; Acedo, A.

10.1101/2021.02.09.430373 — microbiology — Posted on 2021-02-10

2735 Characterization of a Novel Type Homoserine Dehydrogenase Only with High Oxidation Activity from Arthrobacter nicotinovorans

Liang, X.; Deng, h.; Bai, Y.; Fan, T.-p.; Zheng, X.; Cai, Y.

10.1101/2021.02.09.430557 — microbiology — Posted on 2021-02-10

2736 Embedding of exogenous B cell epitopes on the surface of UreB structure generates a broadly reactive antibody response against Helicobacter pylori

Ma, J.; Wang, S.; Ji, Q.; Qiu, J.; Liu, Q.

10.1101/2021.02.09.430551 — immunology — Posted on 2021-02-10

2737 Bifurcated monocyte states are predictive of mortality in severe COVID-19

Cillo, A. R.; Somasundaram, A.; Shan, F.; Cardello, C.; Workman, C. J.; Kitsios, G. D.; Ruffin, A.; Kunning, S.; Lampenfeld, C.; Onkar, S.; Grebinowski, S.; Deshmukh, G.; Methe, B.; Liu, C.; Nambulli, S.; Andrews, L.; Duprex, W. P.; Joglekar, A. J.; Benos, P. V.; Ray, P.; Ray, A.; McVerry, B. J.; Zhang, Y.; Lee, J. S.; Das, J.; Singh, H.; Morris, A.; Bruno, T. C.; Vignali, D. A.

10.1101/2021.02.10.430499 — immunology — Posted on 2021-02-10

2738 A Safe and Effective Mucosal RSV Vaccine Consisting of RSV Phosphoprotein and Flagellin Variant

Zhao, B.; Yang, J.; He, B.; Li, X.; Yan, H.; Liu, S.; Yang, Y.; Zhou, D.; Liu, B.; Fan, X.; Zhong, M.; Zhang, E.; Zhang, F.; Zhang, Y.; Chen, Y.-Q.; Jiang, S.; Yan, H.

10.1101/2021.02.09.430425 — immunology — Posted on 2021-02-10

2739 Catestatin regulates the colonic mucus layer in inflammatory bowel disease

Muntjewerff, E.; Lutter, L.; Tang, K.; Kea-te Lindert, M.; Fransen, J.; Oldenburg, B.; Mahata, S. K.; van den Bogaart, G.

10.1101/2021.02.09.430377 — immunology — Posted on 2021-02-10

2740 DNA repair enzyme NEIL3 enables a stable neural representation of space by shaping transcription in hippocampal neurons

Kunath, N.; Bugaj, A. M.; Bigonah, P.; Fernandez-Berrocal, M. S.; Bjoras, M.; Ye, J.

10.1101/2021.02.09.430416 — neuroscience — Posted on 2021-02-10

2741 Medicago SPX1 and SPX3 regulate phosphate homeostasis, mycorrhizal colonization and arbuscule degradation

Wang, P.; Snijders, R.; Kohlen, W.; Liu, J.; Bisseling, T.; Limpens, E.

10.1101/2021.02.09.430431 — plant biology — Posted on 2021-02-10

2742 Calcium Sensitive Allostery Regulates the PI(4,5)P2 Binding Site of the Dysferlin C2A Domain

Otto, S. C.; Reardon, P. N.; Kumar, T. M.; Kuykendall, C. J.; Johnson, C. P.

10.1101/2021.02.10.430549 — biophysics — Posted on 2021-02-10

2743 Sequence-specific minimizers via polar sets

Zheng, H.; Kingsford, C.; Marcais, G.

10.1101/2021.02.01.429246 — bioinformatics — Posted on 2021-02-10

2744 Immunomodulatory Contribution of Mast Cells to the Biomaterial Microenvironment

Wang, R. M.; Ungerleider, J.; Kawakami, Y.; Kawakami, Y.; Kawakami, T.; Christman, K.

10.1101/2020.07.31.231852 — bioengineering — Posted on 2021-02-10

2745 HIV reverse transcriptase pre-steady-state kinetic analysis of chain terminators and translocation inhibitors reveals interactions between magnesium and nucleotide 3'-OH

Dilmore, C. R.; DeStefano, J. J.

10.1101/2020.12.21.423855 — biochemistry — Posted on 2021-02-10

2746 An Easy-to-Fabricate Cell Stretcher Reveals Density-Dependent Mechanical Regulation of Collective Cell Movements in Epithelia

Hart, K. C.; Sim, J. Y.; Hopcroft, M. A.; Cohen, D. J.; Tan, J.; Nelson, W. J.; Pruitt, B.

10.1101/2020.08.24.265629 — bioengineering — Posted on 2021-02-10

2747 The road to sorghum domestication: evidence from nucleotide diversity and gene expression patterns

Burgarella, C.; Berger, A.; Glemin, S.; David, J.; Terrier, N.; Deu, M.; Pot, D.

10.1101/2020.11.17.386268 — evolutionary biology — Posted on 2021-02-10

2748 Patient derived models of bladder cancer amplify tumor specific gene expression compared to surgical specimen while maintaining gene expression of molecular subtype and epithelial mesenchymal transition markers

Mastri, M.; Ramakrishnan, S.; Shah, S.; Karasik, E.; Gillard, B. M.; Moser, M. M.; Farmer, B. K.; Chatta, G. S.; Woloszynska, A.; Eng, K. H.; Foster, B. A.; HUSS, W. J.

10.1101/2021.02.10.430614 — cancer biology — Posted on 2021-02-10

2749 Evolution Without Variation and Selection

Gabora, L.; Steel, M.

10.1101/2020.08.30.274407 — evolutionary biology — Posted on 2021-02-10

2750 In vitro evolution of Remdesivir resistance reveals genome plasticity of SARS-CoV-2

10.1101/2021.02.01.429199 — microbiology — Posted on 2021-02-10

2751 SARS-CoV-2 infection models using in vivo and in vitro hACE2-lentivirus transduction

Rawle, D. J.; Le, T. T.; Dumenil, T.; Yan, K.; Tang, B.; Bishop, C.; Suhrbier, A.

10.1101/2021.02.09.430547 — microbiology — Posted on 2021-02-10

2752 N-glycan chitobiose core biosynthesis by Agl24 strengthens the hypothesis of an archaeal origin of the eukaryal N-glycosylation

Meyer, B. H.; Wagstaff, B. A.; Adam, P. S.; Albers, S.-V.; Dorfmueller, H. C.

10.1101/2021.01.19.427365 — microbiology — Posted on 2021-02-10

2753 Naive human B cells can neutralize SARS-CoV-2 through recognition of its receptor binding domain

Feldman, J.; Bals, J.; Denis, K. S.; Lam, E. C.; Hauser, B. M.; Ronsard, L.; Sangesland, M.; Moreno, T. B.; Okonkwo, V.; Hartojo, N.; Balazs, A. B.; Lingwood, D.; Schmidt, A. G.

10.1101/2021.02.02.429458 — immunology — Posted on 2021-02-10

2754 The theory of condensin mediated loop extrusion in genomes

Takaki, R.; Dey, A.; Shi, G.; Thirumalai, D.

10.1101/2020.05.27.119578 — biophysics — Posted on 2021-02-10

2755 A multi-dimensional integrative scoring framework for predicting functional variants in the human genome

Li, X.; Yung, G.; Zhou, H.; Sun, R.; Li, Z.; Liu, Y.; Ionita-Laza, I.; Lin, X.

10.1101/2021.01.06.425527 — genetics — Posted on 2021-02-10

2756 Cardiac RyR N-terminal region biosensors for FRET-based high-throughput screening

Zhang, J.; Yuen, S. M. W. K.; Schwarz, J. A.; Treinen, L. M.; Tung, C.-C.; Rebbeck, R. T.; Ro?man, K.; Svensson, B.; Aldrich, C. C.; Thomas, D. D.; Van Petegem, F.; Cornea, R. L.

10.1101/2021.02.07.430153 — biophysics — Posted on 2021-02-10

2757 Mutation bias implicates RNA editing in a wide range of mammalian RNA viruses

Simmonds, P.; Ansari, M. A.

10.1101/2021.02.09.430395 — genomics — Posted on 2021-02-10

2758 Catching SARS-CoV-2 by sequence hybridization: a comparative analysis

Rehn, A.; Braun, P.; Knuepfer, M.; Woelfel, R.; Antwerpen, M. H.; Walter, M. C.

10.1101/2021.02.05.429917 — genomics — Posted on 2021-02-10

2759 CCG*CGG interruptions in high penetrance SCA8 families increase RAN translation and protein toxicity

Perez, B. A.; Shorrock, H. K.; Banez-Coronel, M.; Laboissonniere, L. A.; Reid, T.; Ikeda, Y.; Reddy, K.; Gomez, C. M.; Bird, T.; Ashizawa, T.; Schut, L. J.; Brusco, A.; Berglund, A.; Hasholt, L. F.; Nielsen, J. E.; Subramony, S. H.; Ranum, L. P. W.

10.1101/2021.02.08.430311 — genetics — Posted on 2021-02-10

2760 Rapid spread of a symbiotic virus in a major crop pest following wide-scale adoption of Bt-cotton in China

Wu, K.; Xiao, Y.; Xu, P.; Wilson, K.; Bravo, A.; Soberon, M.; Yang, X.; Yuan, H.; Jin, M.; Zheng, W.; Li, W.

10.1101/2021.02.08.430243 — ecology — Posted on 2021-02-10

2761 The lncRNA EPB41L4A-AS1 regulates gene expression in the nucleus and exerts cell type-dependent effects on cell cycle progression

Samdal, H.; Hegre, S. A.; Chawla, K.; Liabakk, N.-B.; Aas, P. A.; Sporsheim, B.; Saetrom, P.

10.1101/2021.02.10.430566 — molecular biology — Posted on 2021-02-10

2762 Deletion of Serf2 shifts amyloid conformation in an Aβ amyloid mouse model

10.1101/2021.01.05.423442 — molecular biology — Posted on 2021-02-10

2763 A systematic analysis of Trypanosoma brucei chromatin factors identifies novel protein interaction networks associated with sites of transcription initiation and termination

Staneva, D. P.; Carloni, R.; Auchynnikava, T.; Tong, P.; Arulanandam, J. A.; Rappsilber, J.; Matthews, K. R.; Allshire, R.

10.1101/2021.02.09.430399 — molecular biology — Posted on 2021-02-10

2764 Site-specific O-glycosylation analysis of SARS-CoV-2 spike protein produced in insect and human cells

Bagdonaite, I.; Thompson, A. J.; Wang, X.; Soegaard, M.; Fougeroux, C.; Frank, M.; Diedrich, J. K.; Yates, J. R.; Salanti, A.; Vakhrushev, S. Y.; Paulson, J. C.; Wandall, H. H.

10.1101/2021.02.03.429627 — molecular biology — Posted on 2021-02-10

2765 Characterization and structural prediction of the putative ORF10 protein in SARS-CoV-2

Schuster, N. A.

10.1101/2020.10.26.355784 — microbiology — Posted on 2021-02-10

2766 Genetic models of latent tuberculosis in mice reveal differential control by innate and adaptive immunity

Su, H.; Lin, K.; Tiwari, D.; Healy, C.; Trujillo, C.; Liu, Y.; Schnappinger, D.; Ehrt, S.

10.1101/2021.02.08.430271 — microbiology — Posted on 2021-02-10

2767 Emergence of NADP+-reducing enzymes in Escherichia coli central metabolism via adaptive evolution

Bouzon, M.; Döring, V.; Dubois, I.; Berger, A.; Stoffel, G. M. M.; Calzadiaz Ramirez, L.; Meyer, S.; Foure, M.; Roche, D.; Perret, A.; Erb, T. J.; Bar-Even, A.; Lindner, S. N.

10.1101/2021.02.08.430375 — microbiology — Posted on 2021-02-10

2768 Adoptive transfer of allogeneic gamma delta T cells promotes HIV replication in a humanized mouse model

Biradar, S.; Agarwal, Y.; Lotze, M. T.; Rinaldo, C. R.; Bility, M. T.; Mailliard, R. B.

10.1101/2021.02.08.430263 — immunology — Posted on 2021-02-10

2769 C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases

Zwarthoff, S. A.; Widmer, K.; Kuipers, A.; Strasser, J.; Ruyken, M.; Aerts, P.; de Haas, C. J. C.; Ugurlar, D.; Vidarsson, G.; van Strijp, J.; Gros, P.; Parren, P.; van Kessel, K. P. M.; Preiner, J.; Beurskens, F. J.; Schuurman, J.; Ricklin, D.; Rooijakkers, S. H. M.

10.1101/2021.02.08.430229 — immunology — Posted on 2021-02-10

2770 Alternative splicing of auxiliary β2-subunits stabilizes Cav2.3 Ca2+ channel activity in continuously active midbrain dopamine neurons

Siller, A.; Hofer, N. T.; Tomagra, G.; Wiederspohn, N.; Hess, S.; Benkert, J.; Gaifullina, A.; Spaich, D.; Duda, J.; Poetschke, C.; Vilusic, K.; Fritz, E. M.; Schneider, T.; Kloppenburg, P.; Liss, B.; Carabelli, V.; Carbone, E.; Ortner, N. J.; Striessnig, J.

10.1101/2021.02.10.430224 — neuroscience — Posted on 2021-02-10

2771 A novel and specific regulator of neuronal V-ATPase in Drosophila

Dulac, A.; Issa, A.-R.; Sun, J.; Matassi, G.; Cherif-Zahar, B.; Cattaert, D.; Birman, S.

10.1101/2021.02.08.430253 — neuroscience — Posted on 2021-02-10

2772 Feed efficiency of lactating Holstein cows is less reproducible when changing dietary starch and fibre concentrations than within diet over subsequent lactation stages

Fischer, A.; Gasnier, P.; faverdin, p.

10.1101/2021.02.10.430560 — zoology — Posted on 2021-02-10

2773 A rigid body framework for multi-cellular modelling

Brown, P. J.; Green, J. E. F.; Binder, B. J.; Osborne, J. M.

10.1101/2021.02.10.430170 — systems biology — Posted on 2021-02-10

2774 A user manual to measure gas diffusion kinetics in plants: Pneumatron construction, operation and data analysis

Trabi, C.; Pereira, L.; Guan, X.; Miranda, M. T.; Bittencourt, P. R. d. L.; Oliveira, R. S.; Ribeiro, R. V.; Jansen, S.

10.1101/2021.02.08.430283 — plant biology — Posted on 2021-02-10

2775 Root-to-shoot iron partitioning in Arabidopsis requires IRON-REGULATED TRANSPORTER1 (IRT1)

Quintana, J.; Bernal, M. I.; Scholle, M.; Holländer-Czytko, H.; Nga, N.; Piotrowski, M.; Mendoza-Cozatl, D.; Haydon, M. J.; Kraemer, U.

10.1101/2021.02.08.430285 — plant biology — Posted on 2021-02-10

2776 The desert green algae Chlorella ohadii thrives at excessive high light intensities by exceptionally enhancing the mechanisms that protect photosynthesis from photoinhibition

Levin, G.; Kulikovsky, S.; Liveanu, V.; Eichenbaum, B.; Meir, A.; Isaacson, T.; Tadmor, Y.; Adir, N.; Schuster, G.

10.1101/2021.02.08.430232 — plant biology — Posted on 2021-02-10

2777 High-Intensity Interval Training Remodels the Proteome and Acetylome of Human Skeletal Muscle

Hostrup, M.; Lemminger, A. K.; Stocks, B.; Gonzalez-Franquesa, A.; Larsen, J. K.; Thomassen, M.; Weinert, B.; Bangsbo, J.; Deshmukh, A. S.

10.1101/2021.02.10.430602 — physiology — Posted on 2021-02-10

2778 RNF43 inhibits WNT5A driven signaling and suppresses melanoma invasion

Radaszkiewicz, T.; Noskova, M.; Gömöryova, K.; Vondalova Blanarova, O.; Radaszkiewicz, K. A.; Pickova, M.; Vichova, R.; Gybel, T.; Kaiser, K.; Demkova, L.; Kucerova, L.; Potesil, D.; Zdrahal, Z.; Soucek, K.; Bryja, V.

10.1101/2021.02.08.430210 — cancer biology — Posted on 2021-02-10

2779 Topology-based Sparsification of Graph Annotations

Danciu, D.; Karasikov, M.; Mustafa, H.; Kahles, A.; Ratsch, G.

10.1101/2020.11.17.386649 — bioinformatics — Posted on 2021-02-10

2780 SpacePHARER: Sensitive identification of phages from CRISPR spacers in prokaryotic hosts

Zhang, R.; Mirdita, M.; Levy Karin, E.; Norroy, C.; Galiez, C.; Soeding, J.

10.1101/2020.05.15.090266 — bioinformatics — Posted on 2021-02-10

2781 Testing for parallel genomic and epigenomic footprints of adaptation to urban life in a passerine bird

Caizergues, A. E.; Le Luyer, J.; Gregoire, A.; Szulkin, M.; Senar, J. C.; Charmantier, A.; Perrier, C.

10.1101/2021.02.10.430452 — genomics — Posted on 2021-02-10

2782 Genome-wide transcriptome and translatome analyses reveal the role of protein extension and domestication in liver cancer oncogenesis

Wang, N.; Wang, D.

10.1101/2021.02.10.430565 — genomics — Posted on 2021-02-10

2783 Pathfinder: A gamified measure to integrate general cognitive ability into the biological, medical and behavioural sciences

Malanchini, M.; Rimfeld, K.; Gidziela, A.; Cheesman, R.; Allegrini, A. G.; Shakeshaft, N.; Schofield, K.; Packer, A.; Ogden, R.; McMillan, A.; Ritchie, S. J.; Dale, P. S.; Eley, T. C.; von Stumm, S.; Plomin, R.

10.1101/2021.02.10.430571 — genetics — Posted on 2021-02-10

2784 Schizophrenia Risk Alleles Often Affect The Expression of Many Genes and Each Gene May Have a Different Effect On The Risk; A Mediation Analysis.

Peng, X.; Bader, J. S.; Avramopoulos, D.

10.1101/2020.01.27.904680 — genetics — Posted on 2021-02-10

2785 Dung beetles as vertebrate samplers: a test of high throughput analysis of dung beetle iDNA

Drinkwater, R.; Clare, E. L.; Chung, A. Y. C.; Rossiter, S. J.; Slade, E. M.

10.1101/2021.02.10.430568 — ecology — Posted on 2021-02-10

2786 How much does it take to be old? Modelling the time since the last harvesting to infer the distribution of mature forests in France

Thompson, L.; Cateau, E.; Debaive, N.; Bray, F.; Torre, A.; Vallet, P.; Paillet, Y.

10.1101/2021.02.08.430252 — ecology — Posted on 2021-02-10

2787 Supracellular organization confers directionality and mechanical potency to migrating pairs of cardiopharyngeal progenitor cells

Bernadskaya, Y. Y.; Yue, H.; Copos, C.; Christiaen, L.; Mogilner, A.

10.1101/2021.02.09.430466 — developmental biology — Posted on 2021-02-10

2788 A screen for Twist-interacting proteins identifies Twinstar as a regulator of muscledevelopment during embryogenesis

Balakrishnan, M.; Howard, A.; Yu, S. F.; Sommer, K.; Nowak, S. J.; Baylies, M. K.

10.1101/2021.02.10.430492 — developmental biology — Posted on 2021-02-10

2789 Differential bioactivity of four BMP-family members as function of biomaterial stiffness

SALES RAMOS, A.; KHODR, V.; MACHILLOT, P.; FOUREL, L.; GUEVARA GARCIA, A.; MIGLIORINI, E.; ALBIGES RIZO, C.; PICART, C.

10.1101/2021.02.10.430282 — cell biology — Posted on 2021-02-10

2790 Mechanism of Interaction of BMP and Insulin Signaling in C. elegans Development and Homeostasis

Clark, J. F.; Ciccarelli, E. J.; Kayastha, P.; Ranepura, G.; Hasan, M. S.; Melendez, A.; Savage-Dunn, C.

10.1101/777805 — cell biology — Posted on 2021-02-10

2791 Long non-coding RNA Neat1 is a key translational regulator in hypoxia.

Godet, A.-C.; David, F.; Roussel, E.; Hantelys, F.; Morfoisse, F.; Alves, J.; Pujol, F.; Ader, I.; Bertrand, E.; Burlet-Schiltz, O.; Froment, C.; Henras, A.; Vitali, P.; Lacazette, E.; Tatin, F.; Garmy-Susini, B.; Prats, A.-C.

10.1101/2021.02.10.430272 — molecular biology — Posted on 2021-02-10

2792 High current production of Shewanella oneidensis with electrospun carbon nanofiber anodes is directly linked to biofilm formation

Erben, J.; Wang, X.; Kerzenmacher, S.

10.1101/2021.01.28.428465 — microbiology — Posted on 2021-02-10

2793 The ecological significance of extracellular vesicles in modulating host-virus interactions during algal blooms

Schatz, D.; Schleyer, G.; Saltvedt, M. R.; Sandaa, R.-A.; Feldmesser, E.; Vardi, A.

10.1101/2021.02.10.430559 — microbiology — Posted on 2021-02-10

2794 CD29 enriches for cytotoxic human CD4+ T cells

Nicolet, B. P.; Guislain, A.; Wolkers, M. C.

10.1101/2021.02.10.430576 — immunology — Posted on 2021-02-10

2795 A developmental stage- and Kidins220/ARMS-dependent switch in astrocyte responsiveness to brain-derived neurotrophic factor

Jaudon, F.; Albini, M.; Ferroni, S.; Benfenati, F.; Cesca, F.

10.1101/2021.02.10.430582 — neuroscience — Posted on 2021-02-10

2796 Sustained Interleukin-1β overexpression exacerbates Tau pathology in a murine tauopathy model via cyclooxygenase-1

Ghosh, S.; Olschowka, J. A.; O'Banion, M. K.

10.1101/2021.02.10.430570 — neuroscience — Posted on 2021-02-10

2797 The Size-Weight Illusion is unimpaired in individuals with a history of congenital visual deprivation

Pant, R.; Guerreiro, M. J. S.; Ley, P.; Bottari, D.; Shareef, I.; Kekunnaya, R.; Roeder, B.

10.1101/2021.02.10.430572 — neuroscience — Posted on 2021-02-10

2798 Human blood contains circulating cell-free mitochondria, but are they really functional?

Stier, A.

10.1101/2020.12.29.424785 — physiology — Posted on 2021-02-10

2799 Intravital microscopy confirmed microvascular and ECM preservation in the decellularized rat kidney directly after transplantation

Corridon, P. R.

10.1101/2021.02.10.430561 — physiology — Posted on 2021-02-10

2800 SLC4A2 Anion Exchanger Promotes Tumor Cell Malignancy via Enhancing H+ Leak across Golgi Membranes

Khosrowabadi, E.; Rivinoja, A.; Risteli, M.; Tuomisto, A.; Salo, T.; Makinen, M.; Kellokumpu, S.

10.1101/2021.02.09.428406 — cancer biology — Posted on 2021-02-10

2801 Methylation of KRAS at lysine 182 and 184 by SETD7 promotes KRAS degradation

Chiang, C.; Xiao, T.; Fan, S.; Zheng, H.; Li, S.; Guo, W.; Zhang, M.; Zhong, C.; Zeng, J.; Zheng, D.

10.1101/2021.02.10.429309 — cancer biology — Posted on 2021-02-10

2802 Scalable Bias-corrected Linkage Disequilibrium Estimation Under Genotype Uncertainty

Gerard, D.

10.1101/2021.02.08.430270 — bioinformatics — Posted on 2021-02-10

2803 Next-generation sequencing-based bulked segregant analysis without sequencing the parental genomes

Zhang, J.; Panthee, D. R.

10.1101/2021.02.08.430275 — bioinformatics — Posted on 2021-02-10

2804 Struo2: efficient metagenome profiling database construction for ever-expanding microbial genome datasets

Youngblut, N.; Ley, R. E.

10.1101/2021.02.10.430604 — bioinformatics — Posted on 2021-02-10

2805 SALTS: SURFR (small noncoding RNA) And LAGOOn (long noncoding RNA) Transcriptomics Suite

Kasukurthi, M. V.; Houserova, D.; Huang, Y. M.; Barchie, A. A.; Roberts, J. T.; Li, D.; Wu, B.; Huang, J.; Borchert, G. M.

10.1101/2021.02.08.430280 — bioinformatics — Posted on 2021-02-10

2806 Simulating the outcome of amyloid treatments in Alzheimer's Disease from multi-modal imaging and clinical data

Abi Nader, C.; Ayache, N.; Frisoni, G. B.; Robert, P.; Lorenzi, M.

10.1101/2020.09.02.279521 — bioinformatics — Posted on 2021-02-10

2807 EMBER: Multi-label prediction of kinase-substrate phosphorylation events through deep learning

Kirchoff, K. E.; Gomez, S. M.

10.1101/2020.02.04.934216 — bioinformatics — Posted on 2021-02-10

2808 SPARC Data Structure: Rationale and Design of a FAIR Standard for Biomedical Research Data

Bandrowski, A.; Grethe, J. S.; Pilko, A.; Gillespie, T. H.; Pine, G.; Patel, B.; Surles-Zeiglera, M.; Martone, M. E.

10.1101/2021.02.10.430563 — bioinformatics — Posted on 2021-02-10

2809 Deep learning for robust and flexible tracking in behavioral studies for C. elegans

Lu, H.; Bates, K.; Le, K.

10.1101/2021.02.08.430359 — bioengineering — Posted on 2021-02-10

2810 Machine learning reveals cryptic dialects that guide mate choice in a songbird

Wang, D.; Forstmeier, W.; Farine, D.; Maldonado-Chaparro, A. A.; Martin, K.; Pei, Y.; Alarcon-Nieto, G.; Klarevas-Irby, J. A.; Ma, S.; Aplin, L. M.; Kempenaers, B.

10.1101/2021.02.08.430277 — animal behavior and cognition — Posted on 2021-02-10

2811 The Population Structure and Selection Signal Analysis of Shenxian Pigs based on Genome Resequencing Technology

Liu, D.; Cao, H.

10.1101/2021.02.08.430358 — genomics — Posted on 2021-02-10

2812 The putative causal effect of type 2 diabetes in risk of cataract: a Mendelian randomization study in East Asian

Zhang, H.; Xiu, X.; Xue, A.; Yang, Y.; Yang, Y.; Zhao, H.

10.1101/2021.02.08.430342 — genetics — Posted on 2021-02-10

2813 Cas9 targeted enrichment of mobile elements using nanopore sequencing

McDonald, T. L.; Zhou, W.; Castro, C. P.; Mumm, C.; Switzenberg, J. A.; Mills, R. E.; Boyle, A. P.

10.1101/2021.02.10.430605 — genetics — Posted on 2021-02-10

2814 Cardiac Nmnat/NAD+/SIR2 pathways activation mediates endurance exercise resistance to heart defects induced by a high-fat diet in aging Drosophila

Wen, D.; Zheng, L.; Lu, K.; Hou, W.

10.1101/2021.02.10.430616 — genetics — Posted on 2021-02-10

2815 Ongoing production of low-fitness hybrids limits range overlap between divergent cryptic species

Mikkelsen, E. K.; Irwin, D. E.

10.1101/2021.02.09.430089 — evolutionary biology — Posted on 2021-02-10

2816 Simulation of bacterial populations with SLiM

Cury, J.; Haller, B. C.; Achaz, G.; Jay, F.

10.1101/2020.09.28.316869 — evolutionary biology — Posted on 2021-02-10

2817 Prenatal environmental variation, alternative reproductive tactics and the formation of a mixed-kin cooperative society

Shah, S.; Rubenstein, D. R.

10.1101/2021.02.10.430612 — evolutionary biology — Posted on 2021-02-10

2818 Cardiopharyngeal deconstruction and ancestral tunicate sessility

Ferrandez-Roldan, A.; Fabrega-Torrus, M.; Sanchez-Serna, G.; Duran-Bello, E.; Joaquin-Lluis, M.; Garcia-Fernandez, J.; Albalat, R.; Canestro, C.

10.1101/2021.02.10.430586 — evolutionary biology — Posted on 2021-02-10

2819 Complex introgression history of the erato-sara clade of Heliconius butterflies

Thawornwattana, Y.; Seixas, F. A.; Yang, Z.; Mallet, J.

10.1101/2021.02.10.430600 — evolutionary biology — Posted on 2021-02-10

2820 Intermolecular interactions drive protein adaptive and co-adaptive evolution at both species and population levels

Peng, J.; Zhao, L.

10.1101/2021.02.08.430345 — evolutionary biology — Posted on 2021-02-10

2821 Alteration of gut microbiota with a broad-spectrum antibiotic does not impair maternal care in the European earwig.

Van Meyel, S.; Devers, S.; Dupont, S.; Dedeine, F.; Meunier, J.

10.1101/2020.10.08.331363 — evolutionary biology — Posted on 2021-02-10

2822 Body size dependent dispersal influences stability in heterogeneous metacommunities

Anderson, K. E.; Fahimipour, A. K.

10.1101/2021.02.08.430322 — ecology — Posted on 2021-02-10

2823 Vertical stratification of environmental DNA in the open ocean captures ecological patterns and behavior of deep-sea fishes

Canals, O.; Mendibil, I.; Santos, M.; Irigoien, X.; Rodriguez-Ezpeleta, N.

10.1101/2021.02.10.430594 — ecology — Posted on 2021-02-10

2824 How to count your bugs?

Onufrieva, K. S.; Onufriev, A. V.

10.1101/2021.02.08.430281 — ecology — Posted on 2021-02-10

2825 Harmful Algal Bloom-Forming Organism Responds to Nutrient Stress Distinctly From Model Phytoplankton

McLean, C.; Haley, S. T.; Swarr, G. J.; Kido Soule, M. C.; Dyrhman, S. T.; Kujawinski, E. B.

10.1101/2021.02.08.430350 — ecology — Posted on 2021-02-10

2826 Does the ratio of β-1,4-glucosidase (BG) to β-1,4-N-acetylglucosaminidase (NAG) indicate the relative resource allocation of soil microbes to C and N acquisition?

Mori, T.; Aoyagi, R.; Kitayama, K.; Mo, J.

10.1101/2021.02.08.430361 — ecology — Posted on 2021-02-10

2827 An open-source experimental framework for automation of cell biology experiments

Katunin, P.; Cadby, A. J.; Nikolaev, A.

10.1101/2020.07.02.185454 — cell biology — Posted on 2021-02-10

2828 Deletion of Serf2 shifts amyloid conformation in an Aβ amyloid mouse model

10.1101/2021.01.05.423442 — molecular biology — Posted on 2021-02-10

2829 Biased nicking of mitochondrial DNA during extraction can be avoided by choice of isolation method

Repoles, B. M.; Gorospe, C. M.; Tran, P.; Nilsson, A. K.; Wanrooij, P. H.

10.1101/2021.02.10.430587 — molecular biology — Posted on 2021-02-10

2830 Establishment of a reverse genetic system from a bovine derived Influenza D virus isolate.

Holwerda, M.; Laloli, L.; Wider, M.; Schoenecker, L.; Becker, J.; Meylan, M.; Dijkman, R.

10.1101/2021.02.10.430577 — microbiology — Posted on 2021-02-10

2831 Effects of treatment with three antibiotics, vancomycin, neomycin, and AVNM on gut microbiome in C57BL/6 mice

Ray, P.; Chakraborty, S.; Ghosh, A.; Aich, P.

10.1101/2021.02.08.430372 — immunology — Posted on 2021-02-10

2832 Dissociable Roles of Pallidal Neuron Subtypes in Regulating Motor Patterns

Cui, Q.; Pamukcu, A.; Cherian, S.; Chang, I. Y.; Berceau, B.; Xenias, H.; Higgs, M.; Rajamanickam, S.; Chen, Y.; Du, X.; Zhang, Y.; McMorrow, H.; Abecassis, Z.; Boca, S.; Justice, N.; Wilson, C.; Chan, C. S.

10.1101/2020.08.23.263053 — neuroscience — Posted on 2021-02-10

2833 Organisation of afferents along the anterior-posterior and medial-lateral axes of the rat OFC

Barreiros, I. V.; Panayi, M. C.; Walton, M. E.

10.1101/2020.08.28.272591 — neuroscience — Posted on 2021-02-10

2834 In vivo optogenetic stimulation of the primate retina activates the visual cortex after long-term transfection

Chaffiol, A.; Provansal, M.; Joffrois, C.; Blaize, K.; Labernede, G.; Goulet, R.; Burban, E.; Brazhnikova, E.; Duebel, J.; Pouget, P.; Sahel, J.-A.; Picaud, S.; Gauvain, G.; Arcizet, F.

10.1101/2021.02.09.427243 — neuroscience — Posted on 2021-02-10

2835 Feedforward and feedback interactions between visual cortical areas use different population activity patterns

Semedo, J.; Jasper, A. I.; Zandvakili, A.; Aschner, A.; Machens, C.; Kohn, A.; Yu, B. M.

10.1101/2021.02.08.430346 — neuroscience — Posted on 2021-02-10

2836 Unilateral acoustic degradation delays attentional separation of competing speech

Kraus, F.; Tune, S.; Ruhe, A.; Obleser, J.; Woestmann, M.

10.1101/2020.11.20.391391 — neuroscience — Posted on 2021-02-10

2837 Brief stimuli cast a long-term trace in visual cortex

Fritsche, M.; Solomon, S. G.; de Lange, F. P.

10.1101/2021.02.10.430579 — neuroscience — Posted on 2021-02-10

2838 Resting-state brain activity can predict target-independent aptitude in fMRI-neurofeedback training

Nakano, T.; Takamura, M.; Nishimura, H.; Machizawa, M.; Ichikawa, N.; Yoshino, A.; Okada, G.; Okamoto, Y.; Yamawaki, S.; Yamada, M.; Suhara, T.; Yoshimoto, J.

10.1101/2021.02.08.430334 — neuroscience — Posted on 2021-02-10

2839 Augmenting Flexibility: Mutual Inhibition Between Inhibitory Neurons Expands Functional Diversity

Liu, B.; White, A. J.; Lo, C.-C.

10.1101/2020.11.08.371179 — neuroscience — Posted on 2021-02-10

2840 The impact of allometry on vomer shape and its implications for the taxonomy and cranial kinesis of crown-group birds

Plateau, O.; Foth, C.

10.1101/2020.07.02.184101 — zoology — Posted on 2021-02-10

2841 CASP microdomain formation requires cross cell wall stabilization of domains and non-cell autonomous action of LOTR1

Kolbeck, A.; Marhavy, P.; De Bellis, D.; Li, B.; Kamiya, T.; Fujiwara, T.; Kalmbach, L.; Geldner, N.

10.1101/2020.08.21.261255 — plant biology — Posted on 2021-02-10

2842 An angiosperm NLR atlas reveals that NLR gene reduction is associated with ecological specialization and signal transduction component deletion

Liu, Y.; Zeng, Z.; Li, Q.; Jiang, X.-M.; Jiang, Z.; Tang, J.-H.; Zhang, Y.-M.; Chen, D.; Wang, Q.; Chen, J.-Q.; Shao, Z.-Q.

10.1101/2021.02.10.430603 — plant biology — Posted on 2021-02-10

2843 Serum and sputum MMP-9/TIMP-1 in winter sports athletes and swimmers: relationships with airway function

Bougault, V.; Turmel, J.; Boulet, L.-P.

10.1101/2021.02.10.430578 — physiology — Posted on 2021-02-10

2844 Diet High in Soybean Oil Increases Susceptibility to Colitis in Mice

Deol, S. P.; Ruegger, P.; Logan, G.; Shawki, A.; Li, J.; Mitchell, J.; Yu, J.; Piamthai, V.; Radi, S. H.; Newman, J.; Fiehn, O.; McCole, D.; Nair, M. G.; Hsiao, A.; Borneman, J.; Sladek, F. M.

10.1101/2021.02.08.430328 — physiology — Posted on 2021-02-10

2845 A comparative study of genomic adaptations to low nitrogen availability in Genlisea aurea

Goldsborough, T.

10.1101/2021.02.09.430036 — bioinformatics — Posted on 2021-02-10

2846 On the application of BERT models for nanopore methylation detection

Zhang, Y.-z.; Hatakeyama, S.; Yamaguchi, K.; Furukawa, Y.; Miyano, S.; Yamaguchi, R.; Imoto, S.

10.1101/2021.02.08.430070 — bioinformatics — Posted on 2021-02-10

2847 ACE: Explaining cluster from an adversarial perspective

Lu, Y. Y.; Yu, T.; Bonora, G.; Noble, W. S.

10.1101/2021.02.08.428881 — bioinformatics — Posted on 2021-02-10

2848 Patient-specific cell communication networks associate with disease progression in cancer

Gibbs, D. L.; Aguliar, B.; Thorsson, V.; Ratushny, A. V.; Shmulevich, I.

10.1101/2021.02.08.430343 — bioinformatics — Posted on 2021-02-10

2849 Development and validation of a deep learning algorithm and open-source platform for the automatic labelling of motion capture markers

Clouthier, A. L.; Ross, G. B.; Mavor, M. P.; Coll, I.; Boyle, A.; Graham, R. B.

10.1101/2021.02.08.429993 — bioengineering — Posted on 2021-02-10

2850 Reversible blood-brain barrier opening utilizing the membrane active peptide melittin in vitro and in vivo

Linville, R. M.; Komin, A.; Lan, X.; DeStefano, J. G.; Chu, C.; Liu, G.; Walczak, P.; Hristova, K.; Searson, P. C.

10.1101/2021.02.09.430012 — bioengineering — Posted on 2021-02-10

2851 Gene expression plasticity, genetic variation and fatty acid remodelling in divergent populations of a tropical bivalve species

le luyer, J.; Milhade, L.; Reisser, C. M.; Soyez, C.; Monaco, C. J.; Belliard, C.; Le Moullac, G.; Ky, C.-L.; Pernet, F.

10.1101/2021.02.08.429829 — ecology — Posted on 2021-02-10

2852 Single-cell ATAC and RNA sequencing reveal pre-existing and persistent subpopulations of cells associated with relapse of prostate cancer

Taavitsainen, S.; Engedal, N.; Cao, S.; Handle, F.; Prekovic, S.; Wetterskog, D.; Vuorinen, E. M.; Kiviaho, A.; Nätkin, R.; Devlies, W.; Henttinen, S.; Kaarijärvi, R.; Lahnalampi, M.; Kaljunen, H.; Nowakowska, K.; Syvälä, H.; Bläuer, M.; Cremaschi, P.; Claessens, F.; Visakorpi, T.; Tammela, T. L.; Murtola, T.; Granberg, K. J.; Ketola, K.; Mills, I. G.; Attard, G.; Wang, W.; Nykter, M.; Urbanucci, A.

10.1101/2021.02.09.430114 — cancer biology — Posted on 2021-02-10

2853 Customized de novo mutation detection for any variant calling pipeline: SynthDNM

Lian, A.; Guevara, J.; Xia, K.; Sebat, J.

10.1101/2021.02.10.427198 — bioinformatics — Posted on 2021-02-10

2854 Assessing evolutionary and developmental transcriptome dynamics in homologous cell types

Feregrino, C.; Tschopp, P.

10.1101/2021.02.09.430383 — developmental biology — Posted on 2021-02-10

2855 The foraging gene affects alcohol sensitivity, metabolism and memory in Drosophila

Oepen, A. S.; Catalano, J. L.; Azanchi, R.; Kaun, K. R.

10.1101/2021.02.09.430533 — genetics — Posted on 2021-02-10

2856 Neuromesodermal progenitor origin of trunk neural crest in vivo

Lukoseviciute, M.; Mayes, S.; Sauka-Spengler, T.

10.1101/2021.02.10.430513 — developmental biology — Posted on 2021-02-10

2857 Integrated Collection of Stem Cell Bank data, a data portal for standardized stem cell information

Chen, Y.; Sakurai, K.; Maeda, S.; Masui, T.; Okano, H.; Dewender, J.; Seltmann, S.; Kurtz, A.; Masuya, H.; Nakamura, Y.; Sheldon, M.; Schneider, J.; Stacey, G.; Panina, Y.; Fujibuchi, W.

10.1101/2020.08.26.263830 — bioinformatics — Posted on 2021-02-10

2858 EGRET: Edge Aggregated Graph Attention Networks and Transfer Learning Improve Protein-Protein Interaction Site Prediction

Mahbub, S.; Bayzid, M. S.

10.1101/2020.11.07.372466 — bioinformatics — Posted on 2021-02-10

2859 Chloroplast redox state changes indicate cell-to-cell signalling during the hypersensitive response

Lukan, T.; Zupanic, A.; Mahkovec Povalej, T.; Brunkard, J. O.; Jutersek, M.; Baebler, S.; Gruden, K.

10.1101/2021.02.08.430316 — plant biology — Posted on 2021-02-09

2860 Motor Sequences - Separating The Sequence From The Motor. A longitudinal rsfMRI Study

Jaeger, A.-T. P.; Huntenburg, J. M.; Tremblay, S. A.; Schneider, U.; Grahl, S.; Huck, J.; Tardif, C. L.; Villringer, A.; Gauthier, C. J.; Bazin, P.-L.; Steele, C. J.

10.1101/2021.02.09.430495 — neuroscience — Posted on 2021-02-09

2861 Neuronal morphology and physiology, functional brain networks and memory in temporal lobe epilepsy

Douw, L.; Nissen, I. A.; Fitzsimmons, S. M.; Santos, F. A.; Hillebrand, A.; van Straaten, E. C.; Stam, C. J.; de Witt Hamer, P. C.; Baayen, J. C.; Klein, M.; Reijneveld, J. C.; Heyer, D. B.; Verhoog, M. B.; Wilbers, R.; Hunt, S.; Mansvelder, H. D.; Geurts, J. J.; de Kock, C. P.; Goriounova, N. A.

10.1101/2021.01.31.428369 — neuroscience — Posted on 2021-02-10

2862 New exon ignites accelerated evolution of placental gene Nrk in the ancestral lineage of eutherians

Liu, G.; Zhang, C.; Wang, Y.; Dai, G.; Liu, S.-Q.; Wang, W.; Pan, Y.-H.; Ding, J.; Li, H.

10.1101/2021.02.09.430412 — evolutionary biology — Posted on 2021-02-09

2863 Streptococcus pyogenes forms serotype and local environment-dependent inter-species protein complexes

Chowdhury, S.; Khakzad, H.; Bergdahl, G. E.; Lood, R.; Ekstrom, S.; Linke, D.; Malmström, L.; Happonen, L.; Malmström, j.

10.1101/2021.02.09.430411 — microbiology — Posted on 2021-02-09

2864 High expression of CD38 and MHC class II on CD8+ T cells during severe influenza disease reflects bystander activation and trogocytosis

Jia, X.; Chua, B.; Loh, L.; Koutsakos, M.; Kedzierski, L.; Olshanski, M.; Heath, W.; Xu, J.; Wang, Z.; Kedzierska, K.

10.1101/2021.02.09.430410 — immunology — Posted on 2021-02-09

2865 Linking Labs: Interconnecting Experimental Environments

Schultz, T.; Putze, F.; Fehr, T.; Meier, M.; Mason, C.; Ahrens, F.; Herrmann, M.

10.1101/2021.02.09.430407 — neuroscience — Posted on 2021-02-09

2866 Reward enhances online participants' engagement with a demanding auditory task

Bianco, R.; Mills, G.; Rosen, S.; Chait, M.

10.1101/2021.02.09.430467 — neuroscience — Posted on 2021-02-09

2867 Synaptotagmin 7 is enriched at the plasma membrane to promote vesicle docking and control synaptic plasticity

Vevea, J. D.; Kusick, G. F.; Chen, E.; Courtney, K. C.; Watanabe, S.; Chapman, E. R.

10.1101/2021.02.09.430404 — neuroscience — Posted on 2021-02-09

2868 Wing structure and neural encoding jointly determine sensing strategies in insect flight

Weber, A. I.; Daniel, T. L.; Brunton, B. W.

10.1101/2021.02.09.430476 — neuroscience — Posted on 2021-02-09

2869 Interspecies activation correlations reveal functional correspondences between marmoset and human brain areas

Hori, Y.; Clery, J. C.; Schaeffer, D. J.; Menon, R. S.; Everling, S.

10.1101/2021.02.09.430509 — neuroscience — Posted on 2021-02-09

2870 Pinpointing the neural signatures of single-exposure visual recognition memory

Mehrpour, V.; Meyer, T.; Simoncelli, E. P.; Rust, N. C.

10.1101/2020.07.01.182881 — neuroscience — Posted on 2021-02-09

2871 Checkpoint proteins in patients with precancer and cervical cancer

Kayukova, E. V.; Sholokhov, L. F.; Belokrinitskaya, T.; Tereshkov, P. P.; Kayukova Elena,

10.1101/2021.02.09.430409 — cancer biology — Posted on 2021-02-09

2872 Relative brain size and cognitive equivalence in fishes

Triki, Z.; Aellen, M.; Van Schaik, C.; Bshary, R.

10.1101/2021.02.09.430417 — animal behavior and cognition — Posted on 2021-02-09

2873 Reduction of insulin/IGF-1 receptor rejuvenates immunity via positive feedback circuit

Lee, Y.; Jeong, D.-E.; Hwang, W.; Ham, S.; Park, H.-E.; Kwon, S.; Jung, Y.; Ashraf, J. M.; Murphy, C.; Lee, S.-J. V.

10.1101/795781 — genetics — Posted on 2021-02-09

2874 Yield Maintenance Under Drought is Orchestrated by the qDTY12.1-Encoded DECUSSATE Gene of Rice Through a Network With Other Flowering-Associated Genes Across the Genetic Background

de los Reyes, B. G.; Sanchez, J.; Pal Kaur, P.; Pabuayon, I. C. M.; Karampudi, N. B. R.; Kitazumi, A.; Sandhu, N.; Catolos, M.; Kumar, A.

10.1101/2021.02.09.430414 — genetics — Posted on 2021-02-09

2875 Improving germline transmission efficiency in chimeric chickens using a multi-stage injection approach

Naseri, D.; Dormiani, K.; Hajian, M.; Jafarpour, F.; Forouzanfar, M.; Karimi, N.; Nasr-Esfahani, M. H.

10.1101/2021.02.09.430408 — developmental biology — Posted on 2021-02-09

2876 Single cell transcriptomic analysis reveals cellular diversity of murine esophageal epithelium and age-associated mitochondrial dysfunction

Kabir, M. F.; Karami, A.; Cruz-Acuna, R.; Klochkova, A.; Saxena, R.; Mu, A.; Murray, M. G.; Keith, K.; Madzo, J.; Huang, H.; Jelinek, J.; Karakasheva, T.; Hamilton, K. E.; Muir, A. B.; Tetreault, M.-P.; Whelan, K. A.

10.1101/2021.02.08.430312 — molecular biology — Posted on 2021-02-09

2877 A refinement to gene editing in Atlantic salmon using asymmetrical oligonucleotide donors

Straume, A. H.; Kjaerner-Semb, E.; Skaftnesmo, K. O.; Güralp, H.; Lillico, S.; Wargelius, A.; Edvardsen, R. B.

10.1101/2021.02.08.430296 — molecular biology — Posted on 2021-02-09

2878 A linguistic representation in the visual system underlies successful lipreading

Nidiffer, A. R.; Cao, C. Z.; O'Sullivan, A. E.; Lalor, E. C.

10.1101/2021.02.09.430299 — neuroscience — Posted on 2021-02-09

2879 Verbal Labels Facilitate Tactile Texture Discrimination in a Perceptual Learning Task

Arun, I.; Lazar, L.

10.1101/2021.02.09.430389 — neuroscience — Posted on 2021-02-09

2880 Elucidating the patterns of seed-to-seedling transmission of Xanthomonas citri pv. malvacearum, the causal agent of cotton bacterial blight

Mijatovic, J.; Severns, P.; Kemerait, R.; Walcott, R.; Kvitko, B. H.

10.1101/2021.02.09.430464 — plant biology — Posted on 2021-02-09

2881 homeRNA: A self-sampling kit for the collection of peripheral blood and stabilization of RNA

Haack, A. J.; Lim, F. Y.; Kennedy, D. S.; Day, J. H.; Adams, K. N.; Lee, J. J.; Berthier, E.; Theberge, A. B.

10.1101/2021.02.08.430337 — bioengineering — Posted on 2021-02-09

2882 A Human 3D neural assembloid model for SARS-CoV-2 infection

Gleeson, J. G.; Wang, L.; Sievert, D.; Clark, A. E.; Federman, H.; Gastfriend, B. D.; Shusta, E.; Palecek, S.; Carlin, A.; Clark, A. E.

10.1101/2021.02.09.430349 — microbiology — Posted on 2021-02-09

2883 Intranasal type I interferon treatment is beneficial only when administered before clinical signs onset in the SARS-CoV-2 hamster model

Bessiere, P.; Wasniewsk, M.; Picard-Meyer, E.; Servat, A.; Figueroa, T.; Foret-Lucas, C.; Coggon, A.; Lesellier, S.; Boue, F.; Cebron, N.; Gausseres, B.; Trumel, C.; Foucras, G.; Salguero, F. J.; Monchatre-Leroy, E.; Volmer, R.

10.1101/2021.02.09.430458 — microbiology — Posted on 2021-02-09

2884 Long-term stability of avalanche scaling and integrative network organization in prefrontal and premotor cortex

Miller, S. R.; Pajevic, S.; Yu, S.; Plenz, D.

10.1101/2020.11.17.386615 — neuroscience — Posted on 2021-02-09

2885 Adaptations and responses of the common dandelion to low atmospheric pressure in high altitude environments

Arce, C. C. M.; Bont, Z.; Machado, R. A. R.; Cristaldo, P. F.; Erb, M.

10.1101/2021.01.28.428657 — plant biology — Posted on 2021-02-09

2886 The protection of Gαz-null NOD mice from hyperglycemia is sexually dimorphic and only partially β-cell autonomous

Fenske, R. J.; Peter, D. C.; Wienkes, H. N.; Schaid, M. D.; Reuter, A.; Carbajal, K. A.; Kimple, M. E.

10.1101/2021.02.08.430304 — physiology — Posted on 2021-02-09

2887 Cryo-EM Structures of the N501Y SARS-CoV-2 Spike Protein in Complex with ACE2 and Two Potent Neutralizing Antibodies

Zhu, X.; Mannar, D.; Srivastava, S. S.; Berezuk, A.; Demers, J.-P.; Saville, J.; Leopold, K.; Li, W.; Dimitrov, D. S.; Tuttle, K.; Zhou, S.; Chittori, S.; Subramaniam, S.

10.1101/2021.01.11.426269 — biophysics — Posted on 2021-02-09

2888 A genome wide copper-sensitized screen identifies novel regulators of mitochondrial cytochrome c oxidase activity

Garza, N. M.; Griffin, A. T.; Zulkifli, M.; Qiu, C.; Kaplan, C. D.; Gohil, V. M.

10.1101/2020.12.31.424969 — biochemistry — Posted on 2021-02-09

2889 Mutation bias implicates RNA editing in a wide range of mammalian RNA viruses

Simmonds, P.; Ansari, M. A.

10.1101/2021.02.09.430395 — genomics — Posted on 2021-02-09

2890 Pkd1 mutation has no apparent effects on peroxisome structure or lipid metabolism

Terabayashi, T.; Menezes, L. F.; Zhou, F.; Cai, H.; Walter, P. J.; Garraffo, H. M.; Germino, G. G.

10.1101/2021.02.08.430145 — genetics — Posted on 2021-02-09

2891 Prisoner of War dynamics explains the time-dependent pattern of substitution rates in viruses

Ghafari, M.; Simmonds, P.; Pybus, O.; Katzourakis, A.

10.1101/2021.02.09.430479 — evolutionary biology — Posted on 2021-02-09

2892 SDC3 acts as a timekeeper of myogenic differentiation by regulating the insulin/AKT/mTOR axis in muscle stem cell progeny

Jones, F. K.; Phillips, A.; Jones, A. R.; Pisconti, A.

10.1101/2020.08.10.244152 — cell biology — Posted on 2021-02-09

2893 Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons

Gowrishankar, S.; Lyons, L.; Rafiq, N. M.; Roczniak-Ferguson, A.; De Camilli, P.; Ferguson, S.

10.1101/2020.06.13.149443 — cell biology — Posted on 2021-02-09

2894 Argonaute Binding within Human Nuclear RNA and its Impact on Alternative Splicing

Chu, Y.; Yokota, S.; Liu, J.; Johnson, K.; Kilikevicius, A.; Corey, D. R.

10.1101/2021.02.09.430489 — molecular biology — Posted on 2021-02-09

2895 A transferrable and integrative type I-F Cascade for heterologous genome editing and transcription modulation

Xu, Z.; Li, Y.; Cao, H.; Si, M.; Zhang, G.; Woo, P. C.; Yan, A.

10.1101/2021.02.08.430362 — microbiology — Posted on 2021-02-09

2896 Atomic structure of human sapovirus capsid by single particle cryo-electron microscopy

Miyazaki, N.; Murakami, K.; Oka, T.; Miki, M.; Iwasaki, K.; Murata, K.

10.1101/2021.02.09.429995 — microbiology — Posted on 2021-02-09

2897 Population density affects the outcome of competition in co-cultures of Gardnerella species isolated from the human vaginal microbiome

Khan, S.; Hill, J. E.

10.1101/2021.02.09.430506 — microbiology — Posted on 2021-02-09

2898 Transcriptome signature of cell viability predicts drug response and drug interaction for Tuberculosis

Srinivas, V.; Ruiz, R. A.; Pan, M.; Immanuel, S. R. C.; Peterson, E. J. R.; Baliga, N. S.

10.1101/2021.02.09.430468 — microbiology — Posted on 2021-02-09

2899 mRNA based SARS-CoV-2 vaccine candidate CVnCoV induces high levels of virus neutralizing antibodies and mediates protection in rodents

Rauch, S.; Roth, N.; Schwendt, K.; Fotin-Mleczek, M.; Mueller, S. O.; Petsch, B.

10.1101/2020.10.23.351775 — immunology — Posted on 2021-02-09

2900 Connection Failure: Differences in White Matter Microstructure are associated with 5-HTTLPR but not with Risk-Seeking for Losses

Neukam, P. T.; Mueller, D. K.; Deza-Araujo, Y. I.; Pooseh, S.; Witt, S. H.; Rietschel, M.; Smolka, M. N.

10.1101/2021.02.03.429606 — neuroscience — Posted on 2021-02-09

2901 Trading Mental Effort for Confidence in the Metacognitive Control of Value-Based Decision-Making

Lee, D.; Daunizeau, J.

10.1101/837054 — neuroscience — Posted on 2021-02-09

2902 Disruption of nuclear architecture as a cause of COVID-19 induced anosmia

Zazhytska, M.; Kodra, A.; Hoagland, D. A.; Fullard, J.; Shayya, H. J.; Omer, A.; Firestein, S.; Gong, Q.; Canoll, P.; Goldman, J. E.; Roussos, P.; tenOever, B. R.; Overdevest, J. B.; Lomvardas, S.

10.1101/2021.02.09.430314 — neuroscience — Posted on 2021-02-09

2903 A unified model of amino acid homeostasis in mammalian cells

Gauthier-Coles, G.; Vennitti, J.; Zang, Z.; Comb, W. C.; Javed, K.; Broer, A.; Broer, S.

10.1101/2021.02.08.430327 — systems biology — Posted on 2021-02-09

2904 Epidermal TRPV4 ion channels regulate UVB induced sunburn by triggering inflammmasome activation and MAPK signaling

Moore, C.; Choi, S.; Moon, G.; Zhang, J.; Chen, Y.; Liedtke, W.

10.1101/2021.01.09.426056 — physiology — Posted on 2021-02-09

2905 Exosomes from COVID-19 patients carry tenascin-C and fibrinogen-β in triggering inflammatory signals in distant organ cells

Sur, S.; Khatun, M. B.; Steele, R.; Isbell, S.; Ray, R.; Ray, R. B.

10.1101/2021.02.08.430369 — physiology — Posted on 2021-02-09

2906 Mechanistic underpinning of nonuniform collective motions in swarming bacteria

Bera, P.; Abdul, W.; Mondal, J.; Ghosh, P.

10.1101/2021.02.08.430357 — biophysics — Posted on 2021-02-09

2907 The extracellular loops of OmpA control the slow rate of in vitro folding

Franklin, M. W.; Stevens, J. J.; Krise, J.; Slusky, J. S. G.

10.1101/2020.10.08.331546 — biophysics — Posted on 2021-02-09

2908 Graph convolutional networks for drug response prediction

Nguyen, T. T.; Nguyen, T.; Le, D.-H.

10.1101/2020.04.07.030908 — bioinformatics — Posted on 2021-02-09

2909 Dual RNA-Seq analysis of SARS-CoV-2 correlates specific human transcriptional response pathways directly to viral expression

Maulding, N. D.; Seiler, S.; Pearson, A.; Kreusser, N.; Stuart, J.

10.1101/2021.02.09.430517 — bioinformatics — Posted on 2021-02-09

2910 Nse5/6 inhibits the Smc5/6 ATPase to facilitate DNA substrate selection.

Taschner, M.; Basquin, J.; Steigenberger, B.; Schaefer, I.; Soh, Y.-M.; Basquin, C.; Lorentzen, E.; Raeschle, M.; Scheltema, R. A.; Gruber, S.

10.1101/2021.02.09.430422 — biochemistry — Posted on 2021-02-09

2911 Evolution of gene-rich germline restricted chromosomes in black-winged fungus gnats through introgression (Diptera: Sciaridae)

Hodson, C. N.; Jaron, K. S.; Gerbi, S. A.; Ross, L.

10.1101/2021.02.08.430288 — evolutionary biology — Posted on 2021-02-09

2912 An algal symbiont (Breviolum psygmophilum) responds more strongly to chronic high temperatures than its facultatively symbiotic coral host (Astrangia poculata)

Chan, A. N.; Gonzalez-Guerrero, L. A.; Iglesias-Prieto, R.; Burmester, E. M.; Rotjan, R. D.; Finnerty, J. R.; Baums, I. B.

10.1101/2021.02.08.430325 — ecology — Posted on 2021-02-09

2913 Human spinal cord differentiation proceeds rapidly in vitro and only initially maintains differentiation pace in a heterologous environment

Dady, A.; Davidson, L.; Halley, P. A.; Storey, K. G.

10.1101/2021.02.06.429972 — developmental biology — Posted on 2021-02-09

2914 A Cas-BCAR3 co-regulatory circuit controls lamellipodia dynamics

Steenkiste, E. M.; Berndt, J. D.; Pilling, C.; Simpkins, C.; Cooper, J. A.

10.1101/2021.01.29.428899 — cell biology — Posted on 2021-02-09

2915 Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing

johnson, s.; Chu, Y.; Liu, J.; Corey, D. R.

10.1101/2021.02.09.430449 — molecular biology — Posted on 2021-02-09

2916 DNA damage-induced phosphorylation of histone H2A at serine 15 is linked to DNA end resection

Ahmad, S.; Cote, J.

10.1101/2021.02.08.430376 — molecular biology — Posted on 2021-02-09

2917 An adaptive compromise - Conflicting evolutionary pressures on arthropod borne Zika virus dinucleotide composition in mammalian hosts and mosquito vectors

Fros, J. J.; Visser, I.; Tang, B.; Yan, K.; Nakayama, E.; Visser, T. M.; Koenraadt, C. J. M.; van Oers, M. M.; Pijlman, G. P.; Suhrbier, A.; Simmonds, P.

10.1101/2021.02.09.430415 — microbiology — Posted on 2021-02-09

2918 Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro biofilm and in vivo implant infections

de Vor, L.; van Dijk, B.; van Kessel, K. P.; Kavanaugh, J. S.; de Haas, C. J.; Aerts, P. C.; Viveen, M. C.; Boel, E. C.; Fluit, A. C.; Kwiecinski, J. M.; Krijger, G. C.; Ramakers, R. M.; Beekman, F. J.; Dadachova, E.; Lam, M. G.; Vogely, H. C.; van der Wal, B. C.; van Strijp, J. A.; Horswill, A. R.; Weinans, H.; Rooijakkers, S. H.

10.1101/2021.02.09.429966 — microbiology — Posted on 2021-02-09

2919 Novel gut pathobionts confound results in a widely used mouse model of human inflammatory disease

Forster, S. C.; Clare, S.; Beresford-Jones, B. S.; Harcourt, K.; Notley, G.; Stares, M.; Kumar, N.; Soderholm, A. T.; Adoum, A.; Wong, H.; Moron, B.; Brandt, C.; Dougan, G.; Adams, D. J.; Maloy, K. J.; Pedicord, V. A.; Lawley, T. D.

10.1101/2021.02.09.430393 — microbiology — Posted on 2021-02-09

2920 Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5

Harris, A.; Wagner, M.; Du, D.; Raschka, S.; Gohlke, H.; Smits, S. H. J.; Luisi, B. F.; Schmitt, L.

10.1101/2021.02.09.430491 — microbiology — Posted on 2021-02-09

2921 Differential impact of plant secondary metabolites on the soil microbiota

Schütz, V.; Frindte, K.; Cui, J.; Zhang, P.; Hacquard, S.; Schulze-Lefert, P.; Knief, C.; Schulz, M.; Dörmann, P.

10.1101/2021.02.09.430398 — microbiology — Posted on 2021-02-09

2922 Avian influenza A viruses reassort and diversify differently in mallards and mammals

Ganti, K.; Bagga, A.; DaSilva, J.; Shepard, S. S.; Barnes, J. R.; Shriner, S. A.; Koelle, K.; Lowen, A. C.

10.1101/2021.02.08.430042 — microbiology — Posted on 2021-02-09

2923 Soil, senescence and exudate utilisation: Characterisation of the Paragon var. spring bread wheat root microbiome

Prudence, S. M. M.; Newitt, J. T.; Worsley, S. F.; Macey, M. C.; Murrell, J. C.; Lehtovirta-Morley, L.; Hutchings, M. I.

10.1101/2021.02.09.430461 — microbiology — Posted on 2021-02-09

2924 A novel antibody against the furin cleavage site of SARS-CoV-2 spike protein: effects on proteolytic cleavage and ACE2 binding

Spelios, M. G.; Capanelli, J. M.; Li, A. W.

10.1101/2021.02.09.430451 — immunology — Posted on 2021-02-09

2925 SARS-CoV-2 RBD-Tetanus toxoid conjugate vaccine induces a strong neutralizing immunity in preclinical studies

Valdes-Balbin, Y.; Santana-Mederos, D.; Quintero, L.; Fernandez, S.; Rodriguez, L.; Sanchez-Ramirez, B.; Perez, R.; Acosta, C.; Mendez, Y.; Ricardo, M. G.; Hernandez, T.; Bergado, G.; Pi, F.; Valdes, A.; Ramirez, U.; Oliva, R.; Soubal, J.-P.; Garrido, R.; Cardoso, F.; Landys, M.; Farinas, M.; Gonzalez, H.; Enriquez, J.; Noa, E.; Suarez, A.; Fang, C.; Espinosa, L. A.; Ramos, Y.; Gonzalez, L. J.; Climent, Y.; Rojas, G.; Relova-Hernandez, E.; Cabrera, Y.; Losada, S. L.; Boggiano, T.; Ojito, E.; Leon-Monzon, K.; Chiodo, F.; Paquet, F.; Chen, G.; Rivera, D. G.; Garcia-Rivera, D.; Verez-Bencomo, V.

10.1101/2021.02.08.430146 — immunology — Posted on 2021-02-09

2926 GABA administration limits viral replication and pneumonitis in a mouse model of COVID-19

Tian, J.; Middleton, B.; Kaufman, D. L.

10.1101/2021.02.09.430446 — immunology — Posted on 2021-02-09

2927 Value shapes the structure of schematic representations in the medial prefrontal cortex

Paulus, P. C.; Charest, I.; Benoit, R. G.

10.1101/2020.08.21.260950 — neuroscience — Posted on 2021-02-09

2928 Evaluating state space discovery by persistent cohomology in the spatial representation system

Kang, L.; Xu, B.; Morozov, D.

10.1101/2020.10.06.328773 — neuroscience — Posted on 2021-02-09

2929 Single-cell transitional dynamics unravel stimulus- and cell type-dependent signaling outputs of distinct p53 regulatory feedback motifs

Xie, J.; Zhang, L.; Zhu, Y.; Liang, X.; Shi, J.

10.1101/2021.02.08.430353 — systems biology — Posted on 2021-02-09

2930 Thinopyrum intermedium TiAP1 interacts with a chitin deacetylase from Blumeria graminis f. sp. tritici and increases the resistance to Bgt in wheat

Yang, Y.; Fan, P.; Xie, W.; Liu, N.; Niu, Z.; Li, Q.; Song, J.; Tian, Q.; Liu, J.; Bao, Y.; Wang, H.; Feng, D.

10.1101/2021.02.08.430348 — plant biology — Posted on 2021-02-09

2931 Energetic and structural features of SARS-CoV-2 N-protein co-assemblies with nucleic acids

Zhao, H.; Wu, D.; Nguyen, A.; Li, Y.; Adão, R.; Valkov, E.; Patterson, G. H.; Piszczek, G.; Schuck, P.

10.1101/2021.02.08.430344 — biophysics — Posted on 2021-02-09

2932 Transformations, Comparisons, and Analysis of Down to Up Protomer States of Variants of the SARS-CoV-2 Prefusion Spike Protein Including the UK Variant B.1.1.7

peters, m. h.; Basidas, O.; Kokron, D.; Henze, C. E.

10.1101/2021.02.09.430519 — biophysics — Posted on 2021-02-09

2933 The statistics of k-mers from a sequence undergoing a simple mutation process without spurious matches

Blanca, A.; Harris, R. S.; Koslicki, D.; Medvedev, P.

10.1101/2021.01.15.426881 — bioinformatics — Posted on 2021-02-09

2934 Constructing smaller genome graphs via string compression

Qiu, Y.; Kingsford, C.

10.1101/2021.02.08.430279 — bioinformatics — Posted on 2021-02-09

2935 Plasmodium falciparum hydroxymethylbilane synthase does not house any cosynthase activity within the haem biosynthetic pathway

Scott, A. F.; Deery, E.; Lawrence, A.; Warren, M. J.

10.1101/2021.02.09.429727 — biochemistry — Posted on 2021-02-09

2936 Automatic inference of demographic parameters using Generative Adversarial Networks

Wang, Z.; Wang, J.; Kourakos, M.; Hoang, N.; Lee, H. H.; Mathieson, I.; Mathieson, S.

10.1101/2020.08.05.237834 — genomics — Posted on 2021-02-09

2937 High Throughput Nanopore Sequencing of SARS-CoV-2 Viral Genomes from Patient Samples

Pater, A. A.; Bosmeny, M. S.; Parasrampuria, M.; Eddington, S. B.; Ovington, K. N.; Barkau, C. L.; White, A. A.; Metz, P. E.; Sylvain, R. J.; Chilamkurthy, R.; Yinusa, A. O.; Benzinger, S. W.; Hebert, M. M.; Gagnon, K. T.

10.1101/2021.02.09.430478 — genomics — Posted on 2021-02-09

2938 Using target capture to address conservation challenges: population-level tracking of a globally-traded herbal medicine

Manzanilla, V.; Teixidor Toneu, I.; Martin, G.; Hollingsworth, P.; de Boer, H. J.; Kool, A.

10.1101/744318 — genomics — Posted on 2021-02-09

2939 PRESENILIN 1 mutations causing early-onset familial Alzheimer's disease or familial acne inversa differ in their effects on genes facilitating energy metabolism and signal transduction

Barthelson, K.; Dong, Y.; Newman, M.; Lardelli, M.

10.1101/2021.01.26.428321 — genetics — Posted on 2021-02-09

2940 Phenotypic plasticity explains apparent reverse evolution of fat synthesis in parasitoid insects

Visser, B.; Alborn, H. T.; Rondeaux, S.; Haillot, M.; Hance, T.; Rebar, D.; Riederer, J. M.; Tiso, S.; van Eldijk, T. J. B.; Weissing, F. J.; Nieberding, C. M.

10.1101/2020.07.17.208876 — evolutionary biology — Posted on 2021-02-09

2941 Biases in demographic modelling affect our understanding of recent divergence

Momigliano, P.; Florin, A.-B.; Merilä, J.

10.1101/2020.06.03.128298 — evolutionary biology — Posted on 2021-02-09

2942 Non-cell autonomous inhibition of the Shh pathway due to impaired cholesterol biosynthesis requires Ptch1/2

Jaegers, C. E.; Roelink, H.

10.1101/2020.12.10.420588 — developmental biology — Posted on 2021-02-09

2943 Myomegalin regulates Hedgehog pathway by controlling PDE4D at the centrosome

Ge, X.; Peng, H.; Zhang, J.; Ya, A.; Ma, W.; Villa, S.; Sukenik, S.

10.1101/2020.04.24.059923 — cell biology — Posted on 2021-02-09

2944 A potent bispecific nanobody protects hACE2 mice against SARS-CoV-2 infection via intranasal administration

Wu, X.; Cheng, L.; Fu, M.; Huang, B.; Zhu, L.; Xu, S.; Shi, H.; Zhang, D.; Yuan, H.; Nawaz, W.; Yang, P.; Hu, Q.; Liu, Y.; Wu, Z.

10.1101/2021.02.08.429275 — microbiology — Posted on 2021-02-09

2945 The co-stimulatory activity of Tim-3 requires Akt and MAPK signaling and immune synapse recruitment

Kataoka, S.; Manandhar, P.; Lee, J.; Workman, C. J.; Banerjee, H.; Szymczak-Workman, A. L.; Kvorjak, M.; Lohmueller, J.; Kane, L. P.

10.1101/2019.12.30.878520 — immunology — Posted on 2021-02-09

2946 Interactions between auditory statistics processing and visual experience emerge only in late development

Berto, M.; Pietrini, P.; Ricciardi, E.; Bottari, D.

10.1101/2020.12.16.423049 — neuroscience — Posted on 2021-02-09

2947 Probabilistic, entropy-maximizing control of large-scale neural synchronization

Menceloglu, M.; Grabowecky, M.; Suzuki, S.

10.1101/2020.08.09.243295 — neuroscience — Posted on 2021-02-09

2948 Molecular evolutionary trends and biosynthesis pathways in the Oribatida revealed by the genome of Archegozetes longisetosus

Brueckner, A.; Barnett, A. A.; Antoshechkin, I. A.; Kitchen, S. A.

10.1101/2020.12.10.420141 — zoology — Posted on 2021-02-09

2949 Direct imaging of anthrax intoxication in animals reveals shared and individual functions of CMG-2 and TEM-8 in cellular toxin entry

Merritt, C.; Chun, E. M.; Fattah, R. J.; Moayeri, M.; Paliga, D.; Neumann, S.; Heumann, R.; Leppla, S. H.; Bugge, T. H.

10.1101/2021.01.22.427304 — pathology — Posted on 2021-02-09

2950 RNA matchmaking remodels lncRNA structure and promotes PRC2 activity

Balas, M. M.; Hartwick, E. W.; Barrington, C.; Roberts, J. T.; Wu, S. K.; Bettcher, R.; Griffin, A. M.; Kieft, J. S.; Johnson, A. M.

10.1101/2020.04.13.040071 — biochemistry — Posted on 2021-02-09

2951 Inferring linguistic transmission between generations at the scale of individuals

Thouzeau, V.; Affholder, A.; Mennecier, P.; Verdu, P.; Austerlitz, F.

10.1101/441246 — bioinformatics — Posted on 2021-02-09

2952 Rcn3 is Involved in Postnatal Tendon Development by Regulating Collagen Modification and Fibrillogenesis

Park, N. R.; Shetye, S.; Keene, D. R.; Tufa, S.; Hudson, D. M.; Archer, M.; Soslowsky, L. J.; Dyment, N. A.; Joeng, K. S.

10.1101/2020.09.25.313098 — developmental biology — Posted on 2021-02-09

2953 Recurrent emergence and transmission of a SARS-CoV-2 Spike deletion H69/V70

Kemp, S.; Meng, B.; Ferreira, I.; Datir, R.; Harvey, W.; Collier, D.; COVID-19 Genomics UK (COG-UK) consortium, ; Papa, G.; Carabelii, A.; Lytras, S.; Kenyon, J.; Lever, A.; James, L.; Robertson, D. L.; Gupta, R. K.

10.1101/2020.12.14.422555 — microbiology — Posted on 2021-02-09

2954 Genomic analysis of the diversity, antimicrobial resistance and virulence potential of Campylobacter jejuni and Campylobacter coli strains from Chile

Bravo, V.; Katz, A.; Porte, L.; Weitzel, T.; Varela, C.; Gonzalez-Escalona, N.; Blondel, C. J.

10.1101/2020.07.03.182048 — microbiology — Posted on 2021-02-09

2955 SARS-CoV-2 RBD219-N1C1: A Yeast-Expressed SARS-CoV-2 Recombinant Receptor-Binding Domain Candidate Vaccine Stimulates Virus Neutralizing Antibodies and T-cell Immunity in Mice

Pollet, J.; Chen, W.-H.; Versteeg, L.; Keegan, B.; Zhan, B.; Wei, J.; Liu, Z.; Lee, J.; Kundu, R.; Adhikari, R.; Poveda, C.; Villar Mondragon, M. J.; de Araujo Leao, A. C.; Altieri Rivera, J.; Momin, Z.; Gillespie, P. M.; Kimata, J.; Strych, U.; Hotez, P. J.; Bottazzi, M. E.

10.1101/2020.11.04.367359 — immunology — Posted on 2021-02-09

2956 Coronavirus-associated molecular mimicry through homology to a SARS-CoV-2 peptide could be leading to susceptibility in patients with HLA-A*02:01 and HLA-A*24:02 serotypes

Adiguzel, Y.

10.1101/2021.01.28.428642 — immunology — Posted on 2021-02-09

2957 Temporal context actively shapes EEG signatures of time perception

Damsma, A.; Schlichting, N.; van Rijn, H.

10.1101/2020.03.17.995704 — neuroscience — Posted on 2021-02-09

2958 Correcting False Memories: The Effect of Mnemonic Generalization on Original Memory Traces

Muncy, N.; Kirwan, B.

10.1101/2020.04.13.039479 — neuroscience — Posted on 2021-02-09

2959 Graded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerve

Mridha, Z.; de Gee, J. W.; Shi, Y.; Alkashgari, R.; Williams, J.; Suminski, A.; Ward, M. P.; Zhang, W.; McGinley, M. J.

10.1101/2019.12.28.890111 — neuroscience — Posted on 2021-02-09

2960 Confidence-controlled Hebbian learning efficiently extracts category membership from stimuli encoded in view of a categorization task

Berlemont, K.; Nadal, J.-P.

10.1101/2020.08.06.239533 — neuroscience — Posted on 2021-02-09

2961 Automated improvement of stickleback reference genome assemblies with Lep-Anchor software

Kivikoski, M.; Rastas, P.; Löytynoja, A.; Merilä, J.

10.1101/2020.08.18.255596 — genomics — Posted on 2021-02-09

2962 Specification of axial identity by Hoxa2 distinguishes between a phenotypic and molecular ground state in mouse cranial neural crest cells

Pushel, I.; Trainor, P. A.; Krumlauf, R.

10.1101/2021.02.09.430457 — developmental biology — Posted on 2021-02-09

2963 Tankyrase-mediated ADP-ribosylation is a novel regulator of TNF-induced death

Liu, L.; Sandow, J. J.; Leslie Pedrioli, D. M.; Silke, N.; Hu, Z.; Morrish, E.; Chau, D.; Kratina, T.; Kueh, A. J. M.; Hottiger, M. O.; Webb, A. I.; Lalaoui, N.; Silke, J.

10.1101/2021.02.09.430424 — cell biology — Posted on 2021-02-09

2964 A catalytic-independent function of human DNA polymerase Kappa controls the pool of the Checkpoint Kinase 1

Dall'Osto, M.; Pierini, L.; Valery, N.; Hoffmann, J.-S.; Pillaire, M.-J.

10.1101/2021.02.09.430494 — cell biology — Posted on 2021-02-09

2965 Archaeal extracellular vesicles are produced in an ESCRT-dependent manner and promote gene transfer and nutrient cycling in extreme environments

Liu, J.; Cvirkaite-Krupovic, V.; Commere, P.-H.; Yang, Y.; Zhou, F.; Shen, Y.; Forterre, P.; Krupovic, M.

10.1101/2021.02.09.430445 — microbiology — Posted on 2021-02-09

2966 Role of T cells in intrauterine administration of activated peripheral blood mononuclear cells in recurrent implantation failure.

Ricaud, G.; Vaillancourt, C.; Blais, V.; Disdier, M.; Joao, F.; Johnson, B.; Benkhalifa, M.; Miron, P.; Bernier, J.

10.1101/2021.01.06.425452 — immunology — Posted on 2021-02-09

2967 State-Anxiety Modulates the Effect of Emotion Cues on Visual Temporal Sensitivity in Autism Spectrum Disorder

Chakrabarty, M.; Atsumi, T.; Yaguchi, A.; Fukatsu, R.; Ide, M.

10.1101/2021.02.07.430095 — neuroscience — Posted on 2021-02-09

2968 Why are children so distractible? Development of attentional capacities and motor control from childhood to adulthood.

Hoyer, R. S.; Elshafei, H.; Hemmerlin, J.; Bouet, R.; Bidet-Caulet, A.

10.1101/747527 — neuroscience — Posted on 2021-02-09

2969 Quantitative proteomics identifies secreted diagnostic biomarkers as well as tumor-dependent prognostic targets for clear cell Renal Cell Carcinoma

Senturk, A.; Sahin, A. T.; Armutlu, A.; Kiremit, M. C.; Acar, O.; Erdem, S.; Bagbudar, S.; Esen, T.; Tuncbag, N.; Ozlu, N.

10.1101/2021.02.08.430238 — cancer biology — Posted on 2021-02-09

2970 Tiara: Deep learning-based classification system for eukaryotic sequences

Karlicki, M.; Antonowicz, S.; Karnkowska, A.

10.1101/2021.02.08.430199 — bioinformatics — Posted on 2021-02-09

2971 Development and evaluation of a new methodology for Soft Tissue Artifact compensation in the lower limb

Lahkar, B. K.; Rohan, P.-Y.; Assi, A.; Pillet, H.; Bonnet, X.; Thoreux, P.; Skalli, W.

10.1101/2021.02.08.430265 — bioengineering — Posted on 2021-02-09

2972 Evolution of lower levels of inter-locus sexual conflict in D. melanogaster populations under strong selection for rapid development.

Mital, A.; Sarangi, M.; Joshi, A.

10.1101/2021.02.08.430125 — evolutionary biology — Posted on 2021-02-09

2973 How much does it take to be old? Modelling the time since the last harvesting to infer the distribution of mature forests in France

Thompson, L.; Cateau, E.; Debaive, N.; Bray, F.; Bray, F.; Torre, A.; Paillet, Y.

10.1101/2021.02.08.430252 — ecology — Posted on 2021-02-09

2974 Wavelength-dependent effects of artificial light at night on phytoplankton growth and community structure

Diamantopoulou, C.; Christoforou, E.; Dominoni, D. M.; Kaiserli, E.; Czyzewski, J.; Mirzai, N.; Spatharis, S.

10.1101/2021.02.08.430211 — ecology — Posted on 2021-02-09

2975 Ciliary control of meiotic chromosomal pairing mechanics and germ cell morphogenesis

Mytlis, A.; Kumar, V.; Tao, Q.; Deis, R.; Levy, K.; Masek, M.; Eitan, H.; Nather, F.; Shawahny, A.; Bachmann-Gagescu, R.; Roy, S.; Elkouby, Y. M.

10.1101/2021.02.08.430249 — cell biology — Posted on 2021-02-09

2976 A screen for sleep and starvation resistance identifies a wake-promoting role for the auxiliary channel unc79

Murakami, K.; Palermo, J. C.; Stanhope, B. A.; Keene, A. C.

10.1101/2021.02.08.430360 — neuroscience — Posted on 2021-02-09

2977 Repetitive Mild Head Trauma Induces Activity-Mediated Lifelong Brain Deficits in a Novel Drosophila Model

Behnke, J. A.; Ye, C.; Setty, A.; Moberg, K. H.; Zheng, J. Q.

10.1101/2021.02.09.430429 — neuroscience — Posted on 2021-02-09

2978 Numerical calculation of the light propagation in tapered optical fibers for optical neural interfaces

Mach-Batlle, R.; Pisanello, M.; Pisano, F.; De Vittorio, M.; Pisanello, F.; Ciraci, C.

10.1101/2021.02.08.430223 — neuroscience — Posted on 2021-02-09

2979 Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner

Qian, K.-Y.; Zeng, W.-X.; Hao, Y.; Zeng, X.-T.; Liu, H.; Li, L.; Chen, L.; Tian, F.-M.; Chang, C.; Hall, Q.; Song, C.-X.; Gao, S.; Hu, Z.; Kaplan, J.; Li, Q.; Tong, X.-J.

10.1101/2021.02.09.430459 — neuroscience — Posted on 2021-02-09

2980 Recognition of N6-methyladenosine by the YTHDC1 YTH domain studied by molecular dynamics and NMR spectroscopy: The role of hydration

Krepl, M.; Damberger, F.; von Schroetter, C.; Theler, D.; Pokorna, P.; Allain, F.; Sponer, J.

10.1101/2021.02.08.430239 — biophysics — Posted on 2021-02-09

2981 pyconsFold: A fast and easy tool for modelling and docking using distance predictions.

Lamb, J.; Elofsson, A.

10.1101/2021.02.08.430195 — bioinformatics — Posted on 2021-02-09

2982 Methylomic alteration in peripheral blood lymphocytes of prodromal stage and first-episode Chinese Han schizophrenia patients

Liu, Y.; Lang, B.; Smith, R. C.; Wang, G.; Wang, J.; Liu, Y.; Jin, H.; Lyu, H.; Davis, J. M.; Guidotti, A. R.; Zhao, J.; Wu, R.

10.1101/2021.02.07.430160 — genetics — Posted on 2021-02-09

2983 Modeling features of addiction with an oral oxycodone self-administration paradigm

Murphy, C.; Chang, Y.-H.; Pareta, R.; Li, J.-N.; Earnest, T.; Tooley, J. R.; Vachez, Y. M.; Gereau, R.; Copits, B. A.; Kravitz, A. V.; Creed, M. C.

10.1101/2021.02.08.430180 — neuroscience — Posted on 2021-02-09

2984 Germaphobia! Does our Relationship with, and Knowledge of Biodiversity Affect our Attitudes Towards Microbes?

Robinson, J. M.; Cameron, R.; Jorgensen, A.

10.1101/2021.02.08.430200 — scientific communication and education — Posted on 2021-02-09

2985 RNA fragment assembly with experimental restraints

Chojnowski, G.; Zaborowski, R.; Magnus, M.; Bujnicki, J. M.

10.1101/2021.02.08.430198 — bioinformatics — Posted on 2021-02-09

2986 Copy number variation profile-based genomic subtyping of premenstrual dysphoric disorder in Chinese

Xue, H.; Wu, Z.; Long, X.; Ullah, A.; Chen, S.; Mat, W.-K.; Sun, P.; Gao, M.-Z.; Wang, J.-Q.; Wang, H.-J.; Li, X.; Sun, W.-J.; Qiao, M.-Q.

10.1101/2021.02.08.430168 — genomics — Posted on 2021-02-09

2987 An LR framework incorporating sensitivity analysis to model multiple direct and secondary transfer events on skin surface

Gill, P.; Bleka, O.; Roseth, A.; Fonnelop, A. E.

10.1101/2021.02.08.429904 — genetics — Posted on 2021-02-09

2988 Living apart if you can - how genetically and developmentally controlled sex has shaped the evolution of liverworts

He, X.; Flores, J. R.; Sun, Y.; Bowman, J.

10.1101/2021.02.08.430207 — evolutionary biology — Posted on 2021-02-09

2989 Aerosphere occupancy ({psi}) model of lesser short nosed fruit bat (Cynopterus brachyotis Muller, 1838) related to tree species in Asia mountainous paddy fields

Wibowo, A. A.; Basukriadi, A.; Nurdin, E.; Gunawan, J.

10.1101/2021.02.08.430234 — ecology — Posted on 2021-02-09

2990 Maternal obesity programs white and brown adipose tissue transcriptome and lipidome in offspring in a sex-dependent manner

Savva, C.; Helguero, L.; Gonzalez-Garnillo, M.; Melo, T.; couto, d.; Buyandelger, B.; Gustafsson, S.; Liu, J.; Domingues, M. R.; Li, X.; Korach-Andre, M.

10.1101/2021.02.08.430188 — cell biology — Posted on 2021-02-09

2991 No evidence for somatosensory attenuationduring action observation of self-touch

Kilteni, K.; Engeler, P.; Boberg, I.; Maurex, L.; Ehrsson, H. H.

10.1101/2021.02.08.430193 — neuroscience — Posted on 2021-02-09

2992 Using Adaptive Psychophysics to Identify the Neural Network Reset Time in Sub-second Interval Timing

Sadibolova, R.; Sun, S.; Terhune, D.

10.1101/2021.02.08.430050 — neuroscience — Posted on 2021-02-09

2993 Finger somatotopy is preserved after tetraplegia but deteriorates over time

Kikkert, S.; Pfyffer, D.; Verling, M.; Freund, P.; Wenderoth, N.

10.1101/2021.02.08.430185 — neuroscience — Posted on 2021-02-09

2994 On the Gestural Origin of Language Lateralisation: Manual Communication reflects Broca's Asymmetry in Monkeys

Becker, Y.; Margiotoudi, K.; Marie, D.; Roth, M.; Nazarian, B.; Lacoste, R.; Anton, J.-L.; Coulon, O.; Claidiere, N.; Meguerditchian, A.

10.1101/2021.02.09.430276 — neuroscience — Posted on 2021-02-09

2995 Activation of G-protein coupled estradiol receptor 1 in the dorsolateral striatum attenuates preference for cocaine and saccharin in male but not female rats

Quigley, J. A.; Becker, J. B.

10.1101/824078 — neuroscience — Posted on 2021-02-09

2996 Catechin complexed with lysine has potent antitumor activities in human breast cancer xenograft model

Katsoulieris, E. N.; Rodriguez, A. C.

10.1101/2021.02.01.429090 — cancer biology — Posted on 2021-02-09

2997 Agonist-independent Prostaglandin EP3 Receptor signaling is required to prevent insulin hypersecretion and metabolic dysfunction in a non-obese mouse model of insulin resistance

Reuter, A.; Wisinski, J. A.; Peter, D. C.; Schaid, M.; Fenske, R. J.; Kimple, M. E.

10.1101/671289 — physiology — Posted on 2021-02-09

2998 The anterior Hox gene ceh-13 and elt-1/GATA activate the posterior Hox genes nob-1 and php-3 to specify posterior lineages in the C. elegans embryo

Murray, J. I.; Preston, E.; Crawford, J. P.; Rumley, J. D.; Amom, P.; Anderson, B. D.; Sivaramakrishnan, P.; Patel, S. D.; Bennett, B. A.; Lavon, T. D.; Peng, F.; Zacharias, A. L.

10.1101/2021.02.09.430385 — genetics — Posted on 2021-02-09

2999 Pkd1 mutation has no apparent effects on peroxisome structure or lipid metabolism

Terabayashi, T.; Menezes, L. F.; Zhou, F.; Cai, H.; Walter, P. J.; Garraffo, H. M.; Germino, G. G.

10.1101/2021.02.08.430145 — genetics — Posted on 2021-02-09

3000 Investigating receptor-mediated antibody transcytosis using blood-brain barrier organoid arrays

Simonneau, C.; Duschmalé, M.; Gavrilov, A.; Brandenberg, N.; Hoehnel, S.; Ceroni, C.; Lasalle, E.; Knoetgen, H.; Niewoehner, J.; Villaseñor, R.

10.1101/2021.02.09.430382 — cell biology — Posted on 2021-02-09

3001 Deciphering 3D Human Sphygmopalpation Pulse Patterns using "X-ray" Images Acquired from Tactile Robotic Fingers

KONG, K. W.; CHAN, H.-y.; XIE, J.; LEE, F. C. S.; LEUNG, A. Y. L.; GUAN, B.; SHEN, J.; TAAM WONG, V. C.-W.; LI, W. J.

10.1101/2021.01.10.426152 — bioengineering — Posted on 2021-02-09

3002 A new test suggests that balancing selection maintains hundreds of non-synonymous polymorphisms in the human genome

Soni, V.; Vos, M.; Eyre-Walker, A.

10.1101/2021.02.08.430226 — evolutionary biology — Posted on 2021-02-09

3003 Climate, latitude, and land cover predict flying insect biomass across a German malaise trap network

Welti, E. A. R.; Zajicek, P.; Ayasse, M.; Bornholdt, T.; Buse, J.; Dziock, F.; Engelmann, R. A.; Englmeier, J.; Fellendorf, M.; Foerschler, M. I.; Frenzel, M.; Fricke, U.; Ganuza, C.; Hippke, M.; Hoenselaar, G.; Kaus-Thiel, A.; Mandery, K.; Marten, A.; Monaghan, M. T.; Morkel, C.; Muller, J.; Puffpaff, S.; Redlich, S.; Richter, R.; Rojas Botero, S.; Scharnweber, T.; Scheiffarth, G.; Schmidt Yanez, P.; Schumann, R.; Seibold, S.; Steffan-Dewenter, I.; Stoll, S.; Tobisch, C.; Twietmeyer, S.; Uhler, J.; Vogt, J.; Weis, D.; Weisser, W. W.; Wilmking, M.; Haase, P.

10.1101/2021.02.02.429363 — ecology — Posted on 2021-02-09

3004 AF10 (MLLT10) prevents somatic cell reprogramming through regulation of H3K79 methylation

Ugurlu-Cimen, D.; Odluyurt, D.; Sevinc, K.; Ozkan-Kucuk, N. E.; Ozcimen, B.; Demirtas, D.; Enustun, E.; Aztekin, C.; Philpott, M.; Oppermann, U.; Ozlu, N.; Onder, T. T.

10.1101/2020.12.22.423908 — developmental biology — Posted on 2021-02-09

3005 Antagonistic relationship of NuA4 with the Non-Homologous End-Joining machinery at DNA damage sites.

Ahmad, S.; Cote, V.; Cheng, X.; Bourriquen, G.; Sapountzi, V.; Altaf, M.; Cote, J.

10.1101/2021.01.29.428810 — molecular biology — Posted on 2021-02-09

3006 Functional ultrasound imaging of the spreading activity following optogenetic stimulation of the rat visual cortex

Provansal, M.; Labernede, G.; Joffrois, C.; Rizkallah, A.; Goulet, R.; Valet, M.; Deschamps, W.; Ferrari, U.; Chaffiol, A.; Dalkara, D.; Sahel, J.-A.; Tanter, M.; Picaud, S.; Gauvain, G.; Arcizet, F.

10.1101/2021.02.05.429985 — neuroscience — Posted on 2021-02-09

3007 Sustained neural rhythms reveal endogenous oscillations supporting speech perception

van Bree, S.; Sohoglu, E.; Davis, M. H.; Zoefel, B.

10.1101/2020.06.26.170761 — neuroscience — Posted on 2021-02-09

3008 Enhanced habit formation in Tourette syndrome : dopamine release and striatal disinhibition modulate shortcut connections in a hierarchical model of cortico-basal ganglia loops

Scholl, C.; Baladron, J.; Vitay, J.; Hamker, F. H.

10.1101/2021.02.08.430235 — neuroscience — Posted on 2021-02-09

3009 Internal noise measures in coarse and fine motion direction discrimination tasks, and the correlation with autism traits

Orchard, E.; Dakin, S. C.; van Boxtel, J. J. A.

10.1101/561548 — neuroscience — Posted on 2021-02-09

3010 Phenotyping the preterm brain: characterising individual deviations from normative volumetric development in two large infant cohorts

Dimitrova, R.; Arulkumaran, S.; Carney, O.; Chew, A.; Falconer, S.; Ciarrusta, J.; Wolfers, T.; Batalle, D.; Cordero-Grande, L.; Price, A. N.; Teixeira, R. P.; Hughes, E.; Egloff, A.; Hutter, J.; Makropoulos, A.; Robinson, E. C.; Schuh, A.; Vecchiato, K.; Steinweg, J. K.; Macleod, R.; Marquand, A. F.; McAlonan, G.; Rutherford, M. A.; Counsell, S. J.; Smith, S. M.; Rueckert, D.; Hajnal, J. V.; O'Muircheartaigh, J.; Edwards, A. D.

10.1101/2020.08.05.228700 — neuroscience — Posted on 2021-02-09

3011 Patients with ventromedial prefrontal lesions show an implicit approach bias to angry faces

Buades-Rotger, M.; Solbakk, A.-K.; Liebrand, M.; Endestad, T.; Funderud, I.; Siegwardt, P.; Enter, D.; Roelofs, K.; Kraemer, U. M.

10.1101/2020.06.21.162628 — neuroscience — Posted on 2021-02-09

3012 Mapping Transcriptomic Vector Fields of Single Cells

Qiu, X.; Zhang, Y.; Hosseinzadeh, S.; Yang, D.; Pogson, A. N.; Wang, L.; Shurtleff, M.; Yuan, R.; Xu, S.; Ma, Y.; Replogle, J.; Darmanis, S.; Xing, J.; Weissman, J.

10.1101/696724 — systems biology — Posted on 2021-02-09

3013 Discovery of dual inhibitors of KPC-3 and KPC-15 of Klebsiella pneumoniae :an in-silico molecular docking and dynamics study

Sharma, S.; Kumar-M, P.; Yadav, R.; Singh, S.; Sohal, A.; Gupta, N.

10.1101/2019.12.23.886671 — bioinformatics — Posted on 2021-02-09

3014 simATAC: A single-cell ATAC-seq simulation framework

Navidi, Z.; Zhang, L.; Wang, B.

10.1101/2020.08.14.251488 — bioinformatics — Posted on 2021-02-09

3015 Biologically excretable AIE dots for visualizing through the marmosets intravitally: horizons in future clinical nanomedicine

Feng, Z.; Bai, S.; Qi, J.; Sun, C.; Zhang, Y.; Yu, X.; Ni, H.; Wu, D.; Fan, X.; Xue, D.; Liu, S.; Chen, M.; Gong, J.; Wei, P.; He, M.; Lam, J. W. Y.; Li, X.; Tang, B. Z.; Gao, L.; Qian, J.

10.1101/2020.05.26.113316 — bioengineering — Posted on 2021-02-09

3016 Enhanced genetic analysis of type 1 diabetes by selecting variants on both effect size and significance, and by integration with autoimmune thyroid disease

Crouch, D. J. M.; Inshaw, J. R. J.; Robertson, C. C.; Zhang, J.-Y.; Chen, W.-M.; Onengut-Gumuscu, S.; Cutler, A. J.; Sidore, C.; Cucca, F.; Pociot, F.; Concannon, P.; Rich, S. S.; Todd, J. A.

10.1101/2021.02.05.429962 — genetics — Posted on 2021-02-09

3017 Signatures of mito-nuclear coevolution in a warbler species complex

Wang, S.; Ore, M.; Mikkelsen, E. K.; Lee-Yaw, J.; Toews, D. P. L.; Rohwer, S.; Irwin, D. E.

10.1101/2020.04.06.028506 — evolutionary biology — Posted on 2021-02-09

3018 5-Azacytidine: Effects on the Expression of alpha-Cardiac Actin in Pericytes from Human Adipose Tissue

Ferrreira-Silva, V.; Baqui, M. M.; de Molfetta, G. A.; Fontes, A. M.; Zanette, D. L.; Ferreira, F. U.; Orellana, M. D.; Silva, W. A.; Covas, D. T.

10.1101/2021.02.08.430216 — cell biology — Posted on 2021-02-08

3019 Whole genome 6-methyladenosine sequencing (6-mA-Seq) enables bacterial epigenomics studies.

Spurbeck, R. R.; Minard-Smith, A. T.; Catlin, L. A.; Murdoch, R. W.; Chou, R. M.; Albrecht, K. M.

10.1101/2021.02.08.430217 — genomics — Posted on 2021-02-08

3020 Calculating likelihoods and likelihood ratios at SNPs-based mixtures. A reappraisal of the binomial inference, as applied to forensic identity tests

Pascali, V. L.

10.1101/2021.02.08.430218 — genetics — Posted on 2021-02-08

3021 Unexpected distribution of the 4-formylaminooxyvinylglycine (FVG) biosynthetic pathway in Pseudomonas and beyond

Davis, E. W.; Okrent, R. A.; Manning, V. A.; Trippe, K.

10.1101/2021.02.08.430221 — microbiology — Posted on 2021-02-08

3022 Simultaneous functional MRI of socially interacting marmosets

Gilbert, K. M.; Clery, J. C.; Gati, J. S.; Hori, Y.; Mashkovtsev, A.; Zeman, P.; Menon, R. S.; Schaeffer, D. J.; Everling, S.

10.1101/2021.02.08.430294 — neuroscience — Posted on 2021-02-08

3023 Rare long-range cortical connections enhance information processing

Deco, G.; Sanz Perl, Y.; Vuust, P.; Tagliazucchi, E.; Kennedy, H.; Kringelbach, M. L.

10.1101/2021.02.08.430236 — neuroscience — Posted on 2021-02-08

3024 Sensory experience modulates the reorganisation of temporal auditory regions for executive processing

Manini, B.; Vinogradova, V.; Woll, B.; Cameron, D.; Eimer, M.; Cardin, V.

10.1101/2021.02.08.430248 — neuroscience — Posted on 2021-02-08

3025 Avoiding Data Loss: Synthetic MRIs Generated from Diffusion Imaging Can Replace Corrupted Structural Acquisitions For Freesurfer-Seeded Tractography

Beaumont, J.; Gambarota, G.; Prior, M.; Fripp, J.; Reid, L. B.

10.1101/2021.02.08.430215 — neuroscience — Posted on 2021-02-08

3026 Enhanced habit formation in Tourette syndrome : dopamine release and striatal disinhibition modulate shortcut connections in a hierarchical model of cortico-basal ganglia loops

Scholl, C.; Baladron, J.; Vitay, J.; Hamker, F. H.

10.1101/2021.02.08.430235 — neuroscience — Posted on 2021-02-08

3027 Acoustic context modulates natural sound discrimination in auditory cortex through frequency specific adaptation

Lopez Jury, L.; Garcia-Rosales, F.; Gonzalez-Palomares, E.; Koessl, M.; Hechavarria, J. C.

10.1101/2021.02.08.430293 — neuroscience — Posted on 2021-02-08

3028 Automatic Detection of Larval Zebrafish ECG: Computational Tool for High-throughput Cardiac Activity Analysis

Barrett, R.; Hurst, R.; Tarte, E.; Muller, F.; Sik, A.

10.1101/2021.02.08.430220 — physiology — Posted on 2021-02-08

3029 Recognition and Differentiation of Dural Puncture Click Sensation: A Subjective and Objective Prospective Study of Dural Puncture Forces Using Fine-Gauge Spinal Needles

Utsumi, I.; Hascilowicz, T.; Omi, S.

10.1101/2021.02.08.430219 — biophysics — Posted on 2021-02-08

3030 Cover crop residue diversity enhances microbial activity and biomass with additive effects on microbial structure

Shu, X.; Zou, Y.; Shaw, L. J.; Todman, L.; Tibbett, M.; Sizmur, T.

10.1101/2021.02.08.430214 — microbiology — Posted on 2021-02-08

3031 Physiological underpinning of default-mode network emergence in the human infant brain

Yu, Q.; Ouyang, M.; Detre, J. A.; Kang, H.; Hu, D.; Hong, B.; Fang, F.; Peng, Y.; Huang, H.

10.1101/2021.02.08.430158 — neuroscience — Posted on 2021-02-08

3032 Structure of the human SAGA coactivator complex

Nogales, E.; Herbst, D.; Esbin, M.; Louder, R. K.; Dugast-Darzacq, C.; Dailey, G.; Fang, Q.; Darzacq, X.; Tjian, R.

10.1101/2021.02.08.430339 — biophysics — Posted on 2021-02-08

3033 Interpreting machine learning models to investigate circadian regulation and facilitate exploration of clock function

Gardiner, L.-J.; Rusholme-Pilcher, R.; Colmer, J.; Rees, H.; Crescente, J. M.; Carrieri, A. P.; Duncan, S.; Pyzer-Knapp, E. O.; Krishna, R.; Hall, A.

10.1101/2021.02.04.429826 — genomics — Posted on 2021-02-08

3034 POPULATION GENOMIC ANALYSIS OF CRYPTOCOCCUS BRAZILIAN STRAINS REVEALS AN AFRICAN TYPE SUBCLADES DISTRIBUTION

Maufrais, C.; de Oliveira, L.; Bastos, R. W.; Moyrand, F.; Reis, F. C.; Valero, C.; Gimenez, B.; Josefowicz, L. J.; Goldman, G. H.; Rodrigues, M. L.; Janbon, G.

10.1101/2021.02.08.430197 — genomics — Posted on 2021-02-08

3035 celldeath: a tool for detection of cell death in transmitted light microscopy images by deep learning-based visual recognition

La Greca, A.; Perez, N.; Castaneda, S.; Milone, P. M.; Scarafia, M. A.; Möbbs, A. M.; Waisman, A.; Moro, L. N.; Sevlever, G.; Luzzani, C.; Miriuka, S. G.

10.1101/2020.03.22.002253 — cell biology — Posted on 2021-02-08

3036 Separation and enrichment of sodium-motile bacteria using cost-effective microfluidics.

Gurung, J. P.; Navvab Kashani, M.; Agarwal, S.; Peralta, G.; Gel, M.; Baker, M. A.

10.1101/2020.11.24.395772 — microbiology — Posted on 2021-02-08

3037 Neural epidermal growth factor-like 1 protein variant increases survival and modulates the inflammatory and immune responses in human ACE-2 transgenic mice infected with SARS-CoV-2

Biswas, R.; Eaker, S.; Soni, D. K.; Kar, S.; LoBato, D.; Culiat, C.

10.1101/2021.02.08.430254 — immunology — Posted on 2021-02-08

3038 Cell type classification and discovery across diseases, technologies and tissues reveals conserved gene signatures and enables standardized single-cell readouts

Chamberlain, M.; Hanamsagar, R.; Nestle, F. O.; de Rinaldis, E.; Savova, V.

10.1101/2021.02.01.429207 — immunology — Posted on 2021-02-08

3039 Inferring the heritability of large-scale functional networks with a multivariate ACE modeling approach

Ribeiro, F. L.; dos Santos, F. R. C.; Sato, J. R.; Pinaya, W. H. L.; Biazoli Junior, C. E.

10.1101/437335 — neuroscience — Posted on 2021-02-08

3040 Contrasting recruitment of skin-associated adipose depots during cold challenge of mouse and human

Kasza, I.; Kuehn, J.-P.; Volzke, H.; Hernando, D.; Xu, Y. G.; Siebert, J. W.; Gibson, A. L.; Yen, C.-L. E.; Nelson, D. W.; MacDougald, O. A.; Richardson, N. E.; Lamming, D.; Kern, P. A.; Alexander, C.

10.1101/2020.09.16.300533 — physiology — Posted on 2021-02-08

3041 Mitochondriomics reveals the underlying neuoprotective mechanism of TrkB receptor agonist R13 in the 5xFAD mice

Li, X.; Li, T.; Xie, Y.; Zhang, Z.; Liu, J.; Yu, H.; Li, S.; Song, X.; Yang, X.; Liu, G.

10.1101/2021.02.08.430227 — pharmacology and toxicology — Posted on 2021-02-08

3042 Neuroblastoma formation requires unconventional CD4 T cells and myeloid amino acid metabolism

Van de Velde, L.-A.; Allen, E. K.; Crawford, J. C.; Wilson, T. L.; Guy, C. S.; Russier, M.; Zeitler, L.; Bahrami, A.; Finkelstein, D.; Pelletier, S.; Schultz-Cherry, S.; Thomas, P. G.; Murray, P. J.

10.1101/2021.02.08.430292 — cancer biology — Posted on 2021-02-08

3043 Learning Distance-Dependent Motif Interactions: An Explicitly Interpretable Neural Model of Genomic Events

Quinn, T. P.; Nguyen, D.; Nguyen, P.; Gupta, S.; Venkatesh, S.

10.1101/2020.08.27.270967 — bioinformatics — Posted on 2021-02-08

3044 Nascent polypeptide within the exit tunnel ensures continuous translation elongation by stabilizing the translating ribosome

Chadani, Y.; Sugata, N.; Niwa, T.; Ito, Y.; Iwasaki, S.; Taguchi, H.

10.1101/2021.02.02.429294 — biochemistry — Posted on 2021-02-08

3045 O-GlcNAc regulates MTA1 transcriptional activity during breast cancer cells genotoxic adaptation

Xie, X.; Wu, Q.; Zhang, K.; Liu, Y.; Zhang, N.; Chen, Q.; Wang, L.; Li, W.; Zhang, J.; Liu, Y.

10.1101/2021.02.08.430201 — biochemistry — Posted on 2021-02-08

3046 Sharing mating opportunities by coalition males in stump-tailed macaques: elucidation of ecological mechanism by diversion of PvS model

Toyoda, A.; Maruhashi, T.; Malaivijitnond, S.; Koda, H.; Ihara, Y.

10.1101/2020.01.30.927772 — animal behavior and cognition — Posted on 2021-02-08

3047 Social network architecture and the tempo of cumulative cultural evolution

Cantor, M.; Chimento, M.; Smeele, S. Q.; He, P.; Papageorgiou, D.; Aplin, L. M.; Farine, D. R.

10.1101/2020.12.04.411934 — evolutionary biology — Posted on 2021-02-08

3048 Molecular evolutionary dynamics of energy limited microorganisms

Shoemaker, W. R.; Polezhaeva, E.; Givens, K. B.; Lennon, J. T.

10.1101/2021.02.08.430186 — evolutionary biology — Posted on 2021-02-08

3049 Semi-continuous propagation of influenza A virus and its defective interfering particles: analyzing the dynamic competition to select candidates for antiviral therapy

Pelz, L.; Ruediger, D.; Alnaji, F. G.; Genzel, Y.; Brooke, C. B.; Kupke, S. Y.; Reichl, U.

10.1101/2021.02.08.430251 — evolutionary biology — Posted on 2021-02-08

3050 Altered TGFB1 regulated pathways promote accelerated tendon healing in the superhealer MRL/MpJ mouse

Kallenbach, J.; Freeberg, M.; Abplanalp, D.; Lillis, J.; Ashton, J.; Loiselle, A. E.; Buckley, M.; van Wijnen, A.; Awad, H. A.

10.1101/2021.02.08.430308 — cell biology — Posted on 2021-02-08

3051 Tacc3 modulates microtubule network dynamicity and focal adhesion remodeling to affect cranial neural crest cell migration in Xenopus laevis

Bearce, E. A.; Pratt, B.; Rutherford, E. L.; Carandang, L. A.; Lowery, L.

10.1101/2021.02.08.430297 — cell biology — Posted on 2021-02-08

3052 Visualizing endogenous RhoA activity with an improved localization-based, genetically encoded biosensor

Mahlandt, E. K.; Arts, J. J. G.; van der Meer, W. J.; van der Linden, F. H.; Tol, S.; van Buul, J. D.; Gadella, T. W. J.; Goedhart, J.

10.1101/2021.02.08.430250 — cell biology — Posted on 2021-02-08

3053 Force-dependent activation of actin elongation factor mDia1 protects the cytoskeleton from mechanical damage and facilitates stress fiber repair.

Valencia, F. R.; Sandoval, E.; Liu, J.; Plotnikov, S. V.

10.1101/2021.02.08.430278 — cell biology — Posted on 2021-02-08

3054 Architecture of cell-cell junctions in situ reveals a mechanism for bacterial biofilm inhibition

Melia, C.; Bolla, J. R.; Katharios-Lanwermeyer, S.; Mihaylov, D.; Hoffmann, P.; Huo, J.; Wozny, M.; Elfari, L.; Boehning, J.; Owens, R.; Robinson, C. V.; O'Toole, G.; Bharat, T.

10.1101/2021.02.08.430230 — microbiology — Posted on 2021-02-08

3055 Expanded Genomic Sampling of the DesulfobulbalesReveals Distribution and Evolution of Sulfur Metabolisms

Ward, L. M.; Bertran, E.; Johnston, D. T.

10.1101/2021.02.08.430318 — microbiology — Posted on 2021-02-08

3056 The envelope cytoplasmic tail regulates HIV-1 assembly and spread

Snetkov, X.; Haider, T.; Mesner, D.; Groves, N.; Van Engeleburg, S.; Jolly, C.

10.1101/2021.02.08.430194 — microbiology — Posted on 2021-02-08

3057 Ribonucleotide reductase, a novel target for gonorrhea

Narasimhan, J.; Letinski, S.; Jung, S.; Gerasyuto, A.; Wang, J.; Arnold, M.; Chen, G.; Hedrick, J.; Dumble, M.; Ravichandran, K.; Levitz, T.; Cui, C.; Drennan, C. L.; Stubbe, J.; Karp, G.; Branstrom, A.

10.1101/2020.11.19.389957 — microbiology — Posted on 2021-02-08

3058 Top-down acetylcholine enables social discrimination via unlocking action potential generation in olfactory bulb vasopressin cells

Suyama, H.; Egger, V.; Lukas, M.

10.1101/2020.11.09.373845 — neuroscience — Posted on 2021-02-08

3059 Integrated analysis of the methylome and transcriptome of twin almonds (Prunus dulcis D.A.Webb) reveals genomic features associated with non-infectious bud failure

D'Amico-Willman, K. M.; Niederhuth, C.; Willman, M. R.; Gradziel, T. M.; Ouma, W. Z.; Meulia, T.; Fresnedo Ramirez, J.

10.1101/2021.02.08.430330 — plant biology — Posted on 2021-02-08

3060 Extracellular vesicles induce aggressive phenotype of luminal breast cancer cells by PKM2 phosphorylation

Kang, S. Y.; Lee, E. J.; Byun, J. W.; Han, D.; Choi, Y.; Hwang, D. W.; Lee, D. S.

10.1101/2021.02.08.430192 — cancer biology — Posted on 2021-02-08

3061 Efficacy of CDK4/6 inhibitors in preclinical models of malignant pleural mesothelioma

Aliagas, E.; Alay, A.; Martinez-Iniesta, M.; Hernandez-Madrigal, M.; Cordero, D.; Gausachs, M.; Pros, E.; Saigi, M.; Busacca, S.; Sharkley, A.; Dawson, A.; Palmero, R.; Padrones, S.; Aso, S.; Escobar, I.; Ramos, R.; Llatjos, R.; Vidal, A.; Varela, M.; Sanchez-Cespedes, M.; Fennell, D.; Munoz-Pinedo, C.; Villanueva, A.; Sole, X.; Nadal, E.

10.1101/2021.02.08.430196 — cancer biology — Posted on 2021-02-08

3062 Membrane barrels are taller, fatter, inside-out soluble barrels

Dhar, R.; Feehan, R.; Slusky, J. S. G.

10.1101/2021.01.30.428970 — biophysics — Posted on 2021-02-08

3063 Mechanistic insight into substrate processing and allosteric inhibition of human p97

Pan, M.; Yu, Y.; Ai, H.; Zheng, Q.; Xie, Y.; Liu, L.; Zhao, M.

10.1101/2021.02.08.430295 — biophysics — Posted on 2021-02-08

3064 Molecular Mechanism of Capsid Disassembly in Hepatitis B Virus

Ghaemi, Z.; Gruebele, M.; Tajkhorshid, E.

10.1101/2021.02.08.430262 — biophysics — Posted on 2021-02-08

3065 A Generative Approach toward Precision Antimicrobial Peptide Design

Ferrell, J. B.; Remington, J. M.; Van Oort, C. M.; Sharafi, M.; Aboushousha, R.; Janssen-Heininger, Y.; Schneebeli, S. T.; Wargo, M. J.; Wshah, S.; Li, J.

10.1101/2020.10.02.324087 — biophysics — Posted on 2021-02-08

3066 All-Atom MD Simulations of the HBV Capsid Complexed with AT130 Reveal Secondary and Tertiary Structural Changes and Mechanisms of Allostery

Perez Segura, C.; Goh, B. C.; Hadden-Perilla, J. A.

10.1101/2021.02.08.430329 — biophysics — Posted on 2021-02-08

3067 SLIDR and SLOPPR: Flexible identification of spliced leader trans-splicing and prediction of eukaryotic operons from RNA-Seq data

Wenzel, M.; Mueller, B.; Pettitt, J.

10.1101/2020.12.23.423594 — bioinformatics — Posted on 2021-02-08

3068 Network Medicine Framework Shows Proximity of Polyphenol Targets and Disease Proteins is Predictive of the Therapeutic Effects of Polyphenols

do Valle, I. F.; Roweth, H. G.; Malloy, M. W.; Moco, S.; Barron, D.; Battinelli, E.; Loscalzo, J.; Barabasi, A.-L.

10.1101/2020.08.27.270173 — bioinformatics — Posted on 2021-02-08

3069 Software Evaluation for de novo Detection of Transposons

Rodriguez, M.; Makalowski, W.

10.1101/2021.02.08.430290 — bioinformatics — Posted on 2021-02-08

3070 Automatic Landmark Detection of Human Back Surface from Depth Images via Deep Learning

Delgarmi, M.; Heravi, H.; Rahimpour Jounghani, A.; Shahrezie, A.; Ebrahimi, A.; Shamsi, M.

10.1101/2021.02.04.429842 — bioengineering — Posted on 2021-02-08

3071 Plasticity in novel environments induces larger changes in genetic variance than adaptive divergence

Walter, G. M.; Terranova, D.; Clark, J.; Cozzolino, S.; Cristaudo, A.; Hiscock, S. J.; Bridle, J. R.

10.1101/2021.02.08.430333 — evolutionary biology — Posted on 2021-02-08

3072 The epigenetic eraser LSD1 lies at the apex of a reversible erythroid to myeloid cell fate decision

Yu, L.; Myers, G.; Ku, C.-J.; Schneider, E.; Wang, Y.; Singh, S.; Jearawiriyapaisarn, N.; White, A.; Moriguchi, T.; Khoriaty, R.; Yamamoto, M.; Rosenfeld, M. G.; Pedron, J.; Bushweller, J. H.; Lim, K.-C.; Engel, J. D.

10.1101/2021.01.13.426552 — developmental biology — Posted on 2021-02-08

3073 Midkine-a regulates the formation of a fibrotic scar during zebrafish heart regeneration

Grivas, D.; Gonzalez-Rajal, A.; de la Pompa, J. L.

10.1101/2021.01.29.428781 — developmental biology — Posted on 2021-02-08

3074 TAEL 2.0: An Improved Optogenetic Expression System for Zebrafish

LaBelle, J.; Ramos-Martinez, A.; Shen, K.; Motta-Mena, L. B.; Gardner, K. H.; Materna, S. C.; Woo, S.

10.1101/2020.09.24.312470 — developmental biology — Posted on 2021-02-08

3075 The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis

De Marco Zompit, M.; Mooser, C.; Adam, S.; Rossi, S. E.; Jeanrenaud, A.; Leimbacher, P.-A.; Fink, D.; Durocher, D.; Stucki, M.

10.1101/2021.02.08.430274 — cell biology — Posted on 2021-02-08

3076 Genome-wide CRISPR interference screen identifies long non-coding RNA loci required for differentiation and pluripotency

Haswell, J. R.; Mattioli, K.; Gerhardinger, C.; Maass, P. G.; Foster, D. J.; Fernandez, P. P.; Wang, X.; Rinn, J. L.; Slack, F. J.

10.1101/2021.02.08.430256 — molecular biology — Posted on 2021-02-08

3077 NEIL1 and NEIL2 DNA glycosylases regulate anxiety and learning in a cooperative manner

Hildrestrand, G. A.; Rolseth, V.; Kunath, N.; Suganthan, R.; Jensen, V.; Bugaj, A. M.; Fernandez-Berrocal, M. S.; Sikko, S. B.; Vetlesen, S.; Kusnierczyk, A.; Olsen, A.-K.; Guetzkow, K. B.; Rowe, A. D.; Wang, W.; Moldestad, O.; Syrstad, M. D.; Slupphaug, G.; Eide, L.; Klungland, A.; Saetrom, P.; Luna, L.; Ye, J.; Scheffler, K.; Bjoras, M.

10.1101/2021.02.08.430208 — molecular biology — Posted on 2021-02-08

3078 Dengue virus clinical isolates sustain viability of infected hepatic cells by counteracting apoptosis-mediated DNA breakage

Nath, H.; Ghosh, A.; Basu, K.; De, A.; Biswas, S.

10.1101/2020.06.19.162479 — microbiology — Posted on 2021-02-08

3079 Tracking bacterial lineages in complex and dynamic environments with applications to growth control and persistence

Bakshi, S.; Leoncini, E.; Baker, C.; Canas-Duarte, S.; Okumus, B.; Paulsson, J.

10.1101/2020.03.27.006403 — microbiology — Posted on 2021-02-08

3080 Protistan grazing impacts microbial communities and carbon cycling at deep-sea hydrothermal vents

Hu, S. K.; Herrera, E. L.; Smith, A. R.; Pachiadaki, M. G.; Edgcomb, V. P.; Sylva, S. P.; Chan, E. W.; Seewald, J. S.; German, C. R.; Huber, J. A.

10.1101/2021.02.08.430233 — microbiology — Posted on 2021-02-08

3081 Genetic models of latent tuberculosis in mice reveal differential control by innate and adaptive immunity

Su, H.; Lin, K.; Tiwari, D.; Healy, C.; Trujillo, C.; Liu, Y.; Schnappinger, D.; Ehrt, S.

10.1101/2021.02.08.430271 — microbiology — Posted on 2021-02-08

3082 Differential tolerance of Zymoseptoria tritici to altered optimal moisture conditions during the early stages of wheat infection

Boixel, A.-L.; Gelisse, S.; Marcel, T. C.; Suffert, F.

10.1101/867572 — microbiology — Posted on 2021-02-08

3083 Detection of plasmid contigs in draft genome assemblies using customized Kraken databases

Gomi, R.; Wyres, K. L.; Holt, K. E.

10.1101/2020.11.29.402966 — microbiology — Posted on 2021-02-08

3084 Activin A correlates with the worst outcomes in COVID-19 patients, and can be induced by cytokines via the IKK/NF-kappa B pathway

McAleavy, M.; Zhang, Q.; Xu, J.; Pan, L.; Wakai, M.; Ehmann, P. J.; Wipperman, M. F.; Shavlakadze, T.; Hamon, S. C.; Boyapati, A.; Morton, L. G.; Kyratsous, C. A.; Glass, D. J.

10.1101/2021.02.04.429815 — immunology — Posted on 2021-02-08

3085 Fear in the mind's eye: Mental imagery can generate and regulate acquired differential fear conditioned reactivity

Greening, S. G.; Lee, T.-H.; Gregoire, L.; Burleigh, L.; Robinson, T.; Jiang, X.; Mather, M.; Kaplan, J.

10.1101/2021.02.04.429795 — neuroscience — Posted on 2021-02-08

3086 Dentate spikes and external control of hippocampal function

Dvorak, D.; Chung, A.; Park, E. H.; Fenton, A. A.

10.1101/2020.07.20.211615 — neuroscience — Posted on 2021-02-08

3087 Cortical depth-dependent human fMRI of resting-state networks using EPIK

Pais-Roldan, P.; Yun, S. D.; Palomero-Gallagher, N.; Shah, J. N.

10.1101/2020.12.07.414144 — neuroscience — Posted on 2021-02-08

3088 Developmental and behavioral phenotypes in a new mouse model of DDX3X syndrome

Boitnott, A.; Ung, D.; Garcia-Forn, M.; Niblo, K.; Mendonca, D.; Flores, M.; Maxwell, S.; Ellegood, J.; Qiu, L. R.; Grice, D. E.; Lerch, J. P.; Rasin, M.-R.; Buxbaum, J. D.; Drapeau, E.; De Rubeis, S.

10.1101/2021.01.22.427482 — neuroscience — Posted on 2021-02-08

3089 The Memory for Latent Representations: An Account of Working Memory that Builds on Visual Knowledge for Efficient and Detailed Visual Representations

Hedayati, S.; O'Donnell, R.; Wyble, B.

10.1101/2021.02.07.430171 — neuroscience — Posted on 2021-02-08

3090 Using induced pluripotent stem cells to investigate human neuronal phenotypes in 1q21.1 deletion and duplication syndrome.

Chapman, G.; Alsaqati, M.; Lunn, S.; Singh, T.; Linden, S. C.; Linden, D. E. J.; van den Bree, M. B.; Ziller, M.; Owen, M.; Hall, J.; Harwood, A.; Syed, Y. A.

10.1101/2021.02.08.430246 — neuroscience — Posted on 2021-02-08

3091 Repression by the Arabidopsis TOPLESS corepressor requires association with the core Mediator complex

Leydon, A. R.; Wang, W.; Gala, H. P.; Gilmour, S.; Juarez-Solis, S.; Zemke, J. E.; Zahler, M. L.; Zheng, N.; Nemhauser, J. L.

10.1101/2020.03.04.976134 — plant biology — Posted on 2021-02-08

3092 CRISPR screening identifies novel PARP inhibitor classification based on distinct base excision repair pathway dependencies

Breuer, G. A.; Bezney, J.; Fons, N. R.; Sundaram, R. K.; Feng, W.; Gupta, G. P.; Bindra, R. S.

10.1101/2020.10.18.333070 — cancer biology — Posted on 2021-02-08

3093 CIP2A is a prime synthetic-lethal target for BRCA-mutated cancers

Adam, S.; Rossi, S. E.; Moatti, N.; De Marco Zompit, M.; Ng, T. F.; Alvarez-Quilon, A.; Desjardins, J.; Bhaskaran, V.; Martino, G.; Setiaputra, D.; Noordermeer, S. M.; Ohsumi, T. K.; Hustedt, N.; Szilard, R. K.; Chaudhary, N.; Munro, M.; Veloso, A.; Melo, H.; Yin, S. Y.; Papp, R.; Young, J. T. F.; Zinda, M.; Stucki, M.; Durocher, D.

10.1101/2021.02.08.430060 — cancer biology — Posted on 2021-02-08

3094 The outer membrane loops of OmpA control the slow rate of in vitro folding

Franklin, M. W.; Stevens, J. J.; Krise, J.; Slusky, J. S. G.

10.1101/2020.10.08.331546 — biophysics — Posted on 2021-02-08

3095 SARS-CoV-2 Encodes a PPxY Late Domain Motif Known to Enhance Budding and Spread in Enveloped RNA Viruses

Maaroufi, H.

10.1101/2020.04.20.052217 — bioinformatics — Posted on 2021-02-08

3096 Deriving Ranges of Optimal Estimated Transcript Expression Due to Non-identifiability

Zheng, H.; Ma, C.; Kingsford, C.

10.1101/2019.12.13.875625 — bioinformatics — Posted on 2021-02-08

3097 Structure and inhibitor binding characterization of oncogenic MLLT1 mutants

Ni, X.; Londregan, A. T.; Owen, D. R.; Knapp, S.; Chaikuad, A.

10.1101/2021.02.08.430291 — biochemistry — Posted on 2021-02-08

3098 Mechanisms of GPCR hijacking by Staphylococcus aureus

Grison, C. M.; Leyrat, C.; Lambey, P.; Jeannot, S.; Del Nero, E.; Fontanel, S.; Peysson, F.; Heuninck, J.; Sounier, R.; Durroux, T.; Granier, S.; Bechara, C.

10.1101/2021.02.08.430206 — biochemistry — Posted on 2021-02-08

3099 Mobile Element Insertions and Associated Structural Variants in Longitudinal Breast Cancer Samples

Steely, C. J.; Russell, K. L.; Feusier, J. E.; Qiao, Y.; Tavtigian, S. V.; Marth, G.; Jorde, L. B.

10.1101/2020.02.10.942680 — genomics — Posted on 2021-02-08

3100 Mosquito sound communication: are male swarms loud enough to attract females?

Feugere, L.; Gibson, G.; Manoukis, N. C.; Roux, O.

10.1101/2020.09.01.277202 — ecology — Posted on 2021-02-08

3101 CHD4-NURD controls mouse neonate spermatogonia survival

de Castro, R. O.; Goitea, V.; Previato, L.; Carbajal, A.; Griffin, C.; Pezza, R.

10.1101/687137 — developmental biology — Posted on 2021-02-08

3102 The Pebble/Rho1/Anillin pathway controls polyploidization and axonal wrapping activity in the glial cells of the Drosophila eye

Tavares, L.; Gracio, P.; Ramos, R.; Traquete, R.; Relvas, J. B.; Pereira, P. S.

10.1101/2020.02.12.945600 — developmental biology — Posted on 2021-02-08

3103 FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in Bacillus subtilis cell division

Whitley, K. D.; Jukes, C.; Tregidgo, N.; Karinou, E.; Almada, P.; Henriques, R. D.; Dekker, C.; Holden, S.

10.1101/2020.07.01.182006 — microbiology — Posted on 2021-02-08

3104 Dendrimer-targeted immunosuppression of microglia reactivity super-accelerates photoreceptor regeneration in the zebrafish retina

Emmerich, K. B.; White, D. T.; Kambhampati, S. P.; Lee, G. Y.; Fu, T.-M.; Sahoo, A.; Saxena, M. T.; Betzig, E.; Kannan, R. M.; Mumm, J. S.

10.1101/2020.08.05.238352 — neuroscience — Posted on 2021-02-08

3105 Imaging biomarkers for primary motor outcome after stroke - should we include information from beyond the primary motor system?

Sperber, C.; Rennig, J.; Karnath, H.-O.

10.1101/2020.07.20.212175 — neuroscience — Posted on 2021-02-08

3106 Reliability of web-based affective auditory stimulus presentation

Seow, T. X.; Hauser, T. U.

10.1101/2021.02.08.430267 — neuroscience — Posted on 2021-02-08

3107 Effect of using a physical assistance device for movements involving trunk bending

Jelti, Z.; Lebel, K.; Bastide, S.; Le Borgne, P.; Slangen, P.; Vignais, N.

10.1101/2021.02.08.429597 — physiology — Posted on 2021-02-08

3108 Acyl chain shortening induced by inhibition of acetyl-CoA carboxylase renders phosphatidylcholine redundant

Bao, X.; Koorengevel, M. C.; Groot Koerkamp, M. J. A.; Homavar, A.; Weijn, A.; Crielaard, S.; Renne, M. F.; Geerts, W. J. C.; Surma, M. A.; Mari, M.; Holstege, F. C. P.; Klose, C.; de Kroon, A. I. P. M.

10.1101/2021.02.08.429707 — biochemistry — Posted on 2021-02-08

3109 Sexual dimorphism in gene expression: coincidence and population genomics of two forms of differential expression in Drosophila melanogaster

Singh, A.; Agrawal, A. F.

10.1101/2021.02.08.429268 — evolutionary biology — Posted on 2021-02-08

3110 Zoom in on Ca2+ pattern and ion flux dynamics to decode spatial and temporal regulation of cotton fiber growth

Yang, J.-S.; Bose, J.; Shabala, S.; Ruan, Y.-L.

10.1101/2021.02.08.430284 — cell biology — Posted on 2021-02-08

3111 Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay

Cairrao, F.; Santos, C.; Le-Thomas, A.; Marsters, S.; Ashkenazi, A.; Domingos, P.

10.1101/2021.02.08.430300 — cell biology — Posted on 2021-02-08

3112 A novel rubi-like virus in the Pacific electric ray (Tetronarce californica) reveals the complex evolutionary history of the Matonaviridae

Grimwood, R. M.; Holmes, E. C.; Geoghegan, J. L.

10.1101/2021.02.08.430315 — microbiology — Posted on 2021-02-08

3113 Global warming readiness: Feasibility of enhanced biological phosphorus removal from wastewater at 35oC

Qiu, G.; Law, Y.; Zuniga-Montanez, R.; Lu, Y.; Roy, S.; Thi, S. S.; Hoon, H. Y.; Nguyen, T. Q. N.; Eganathan, K.; Liu, X.; Nielsen, P. H.; Williams, R.; Wuertz, S.

10.1101/2021.02.08.429585 — microbiology — Posted on 2021-02-08

3114 The role of arbuscular mycorrhiza and organosulfur mobilizing bacteria in plant sulphur supply

Gahan, J.; O'Sullivan, O.; Cotter, P. D.; Schmalenberger, A.

10.1101/2021.02.08.429889 — microbiology — Posted on 2021-02-08

3115 Comparison of Janus kinase inhibitors to block the type I interferon pathway in human skeletal muscle cells

Kinder, T. B.; Inglese, J.

10.1101/2021.02.08.430317 — immunology — Posted on 2021-02-08

3116 New skill acquisition does not perturb existing function in sensory cortex

Jeon, B. B.; Chase, S. M.; Kuhlman, S.

10.1101/2021.02.08.430302 — neuroscience — Posted on 2021-02-08

3117 Brain age relates to early life factors but not to accelerated brain aging

Vidal-Pineiro, D.; Wang, Y.; Krogsrud, S. K.; Amlien, I. K.; Baare, W. F.; Bartres-Faz, D.; Bertram, L.; Brandmaier, A. M.; Drevon, C. A.; Duzel, S.; Ebmeier, K. P.; Henson, R. N.; Junque, C.; Kievit, R.; Kuhn, S.; Leonardsen, E.; Lindenberger, U.; Madsen, K. S.; Magnussen, F.; Mowinckel, A. M.; Nyberg, L.; Roe, J. M.; Segura, B.; Sorensen, O.; Suri, S.; Zsoldos, E.; AIBL, ; Walhovd, K. B.; Fjell, A. M.

10.1101/2021.02.08.428915 — neuroscience — Posted on 2021-02-08

3118 Phellem translational landscape throughout secondary development in Arabidopsis roots

Leal, A. R.; Barros, P.; Parizot, B.; Sapeta, H.; Vangheluwe, N.; Andersen, T. G.; Beeckman, T.; Oliveira, M. M.

10.1101/2021.02.08.429142 — plant biology — Posted on 2021-02-08

3119 Key metabolic pathways involved in seed primary physiological dormancy maintenance of Korean pine seed

Song, Y.; Gao, X.

10.1101/2021.02.08.430286 — physiology — Posted on 2021-02-08

3120 Identifying complex sequence patterns in massive omics data with a variable-convolutional layer in deep neural network

Li, J.-Y.; Jin, S.; Tu, X.-M.; Ding, Y.; Gao, G.

10.1101/508242 — bioinformatics — Posted on 2021-02-08

3121 CAMAP: Artificial neural networks unveil the role of codon arrangement in modulating MHC-I peptides presentation

Daouda, T.; Dumont-Lagace, M.; Feghaly, A.; Benslimane, Y.; Panes, R.; Courcelles, M.; Benhammadi, M.; Harrington, L.; Thibault, P.; Major, F.; Bengio, Y.; Gagnon, E.; Lemieux, S.; Perreault, C.

10.1101/2020.06.03.078824 — bioinformatics — Posted on 2021-02-08

3122 A new test suggests that balancing selection maintains hundreds of non-synonymous polymorphisms in the human genome

Soni, V.; Vos, M.; Eyre-Walker, A.

10.1101/2021.02.08.430226 — evolutionary biology — Posted on 2021-02-08

3123 Limiting the loss of terrestrial ecosystems to safeguard nature for biodiversity and humanity

Simmonds, J. S.; Suarez-Castro, A. F.; Reside, A. E.; Watson, J. E. M.; Allan, J. R.; Borrelli, P.; Dudley, N.; Edwards, S.; Fuller, R. A.; Game, E. T.; Linke, S.; Maxwell, S. L.; Panagos, P.; Puydarrieux, P.; Quetier, F.; Runting, R. K.; Santini, T.; Sonter, L. J.; Maron, M.

10.1101/2021.02.07.428694 — ecology — Posted on 2021-02-08

3124 TRF2-mediated ORC recruitment underlies telomere stability upon DNA replication stress

Higa, M.; Matsuda, Y.; Yamada, J.; Sugimoto, N.; Yoshida, K.; Fujita, M.

10.1101/2021.02.08.430303 — cell biology — Posted on 2021-02-08

3125 A human antibody with blocking activity to RBD proteins of multiple SARS-CoV-2 variants including B.1.351 showed potent prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus macaques

Gu, C.; cao, X.; Wang, Z.; Hu, X.; Yao, Y.; Zhou, Y.; Liu, P.; Liu, X.; Gao, G.; Hu, X.; Liang, H.; Chen, Z.; Gao, L.; Peng, Y.; Jia, F.; Shan, C.; Yu, L.; Liu, K.; Li, N.; Guo, W.; Jiang, G.; Min, J.; Zhang, J.; Yang, L.; Shi, M.; Hou, T.; Li, Y.; Liang, W.; Lu, G.; Yang, C.; Wang, Y.; Xia, K.; Xiao, Z.; Xue, J.; Huang, X.; Chen, X.; Ma, H.; Song, D.; Pan, Z.; Wang, X.; Guo, H.; Liang, H.; Yuan, Z.; Guan, W.; Deng, S.-J.

10.1101/2021.02.07.429299 — microbiology — Posted on 2021-02-08

3126 Consistent population activity on the scale of minutes in the mouse hippocampus

Liu, Y.; Levy, S. J.; Mau, W.; Geva, N.; Rubin, A.; Ziv, Y.; Hasselmo, M.; Howard, M.

10.1101/2021.02.07.430172 — neuroscience — Posted on 2021-02-08

3127 Insulin-Like Growth Factor I Couples Metabolism With Circadian Activity Through Hypothalamic Orexin Neurons

Pignatelli, J.; Fernandez de Sevilla, M. E.; Sperber, J.; Horrillo, D.; Medina-Gomez, G.; Torres Aleman, I.

10.1101/2021.02.07.429949 — neuroscience — Posted on 2021-02-08

3128 A DNA-origami NanoTrap for studying the diffusion barriers formed by Phe-Gly-rich nucleoporins

Shen, Q.; Tian, T.; Xiong, Q.; Fisher, P. D. E.; Xiong, Y.; Melia, T.; Lusk, C. P.; Lin, C.

10.1101/2021.02.07.430177 — synthetic biology — Posted on 2021-02-08

3129 Validation of biosignatures confirms the informative nature of fossil organic Raman spectra

Wiemann, J.; Briggs, D. E. G.

10.1101/2021.02.07.430162 — paleontology — Posted on 2021-02-08

3130 Modeling mutational effects on biochemical phenotypes using convolutional neural networks: application to SARS-CoV-2

Wang, B.; Gamazon, E. R.

10.1101/2021.01.28.428521 — bioinformatics — Posted on 2021-02-08

3131 Genome-wide Detection of Cytosine Methylations in Plant from Nanopore sequencing data using Deep Learning

Ni, P.; Huang, N.; Nie, F.; Zhang, J.; Zhang, Z.; Wu, B.; Liu, W.; Bai, L.; Xiao, C.-L.; Luo, F.; Wang, J.

10.1101/2021.02.07.430077 — bioinformatics — Posted on 2021-02-08

3132 Decoding nucleosome positions with ATAC-seq data at single-cell level

Xu, B.; Li, X.; Gao, X.; Jia, Y.; Li, F.; Zhang, Z.

10.1101/2021.02.07.430096 — bioinformatics — Posted on 2021-02-08

3133 Behavioural adaptations in egg laying ancestors facilitate evolutionary transitions to live birth

Pettersen, A. K.; Feiner, N.; Noble, D. W. A.; While, G. M.; Cornwallis, C. K.; Uller, T.

10.1101/2021.02.07.430163 — evolutionary biology — Posted on 2021-02-08

3134 Heterogeneous strains in tissue collagen show that high strains locally suppress degradation by collagenase

Saini, K.; Tiwari, M.; Cho, S.; Jalil, A.; Vashisth, M.; Irianto, J.; Andrechak, J.; Dooling, L.; Alvey, C.; Kasznel, A.; Chenoweth, D. M.; Yamamoto, K.; Discher, D.

10.1101/2021.02.07.430141 — molecular biology — Posted on 2021-02-08

3135 Heterologous expression of human pro-inflammatory Caspase-1 in Saccharomyces cerevisiae and comparison to pro-apoptotic Caspase-8

Valenti, M.; Molina, M.; Cid, V. J.

10.1101/2021.02.07.430150 — molecular biology — Posted on 2021-02-08

3136 A viral protein utilizes the NDP52/CALCOCO2 selective autophagy receptor to disassemble processing bodies

Robinson, C.-A.; Singh, G. K.; Castle, E. L.; Boudreau, B. Q.; Corcoran, J.

10.1101/2021.02.07.430164 — microbiology — Posted on 2021-02-08

3137 Fingerprinting and behavioural prediction rest on distinct functional systems of the human connectome

Mantwill, M.; Gell, M.; Krohn, S.; Finke, C.

10.1101/2021.02.07.429922 — neuroscience — Posted on 2021-02-08

3138 Investigation of layer specific BOLD in the human visual cortex during visual attention

van Mourik, T.; Koopmans, P. J.; Bains, L.; Norris, D.; Jehee, J. F.

10.1101/2021.02.07.430129 — neuroscience — Posted on 2021-02-08

3139 Age-related deficits in rapid visuomotor decision-making

Gomez-Granados, A.; Barany, D.; Schrayer, M.; Kurtzer, I.; Bonnet, C. T.; Singh, T.

10.1101/2021.02.07.430152 — neuroscience — Posted on 2021-02-08

3140 Non-linear Dimensionality Reduction on Extracellular Waveforms Reveals Physiological, Functional, and Laminar Diversity in Premotor Cortex

Lee, E. K.; Balasubramanian, H.; Tsolias, A.; Anakwe, S.; Medalla, M.; Shenoy, K. V.; Chandrasekaran, C.

10.1101/2021.02.07.430135 — neuroscience — Posted on 2021-02-08

3141 Two distinct types of nodes of Ranvier support auditory nerve function in the mouse cochlea

Panganiban, C.; Barth, J. L.; Tan, J.; Kenyaria, N. V.; McClaskey, C. M.; Dias, J. W.; Harris, K. C.; Lang, H.

10.1101/2021.02.07.430087 — neuroscience — Posted on 2021-02-08

3142 What is the state space of the world for real animals?

K Namboodiri, V. M.

10.1101/2021.02.07.430001 — neuroscience — Posted on 2021-02-08

3143 Disulfide-rich, cyclic peptides from Clitoria ternatea protect against β-amyloid toxicity and oxidative stress in transgenic Caenorhabditis elegans

Kalmankar, N. V.; Hari, H.; Sowdhamini, R.; Venkatesan, R.

10.1101/2021.02.07.430179 — plant biology — Posted on 2021-02-08

3144 Epstein-Barr virus long non-coding RNA RPMS1 full-length spliceome in transformed epithelial tissue

Holmqvist, I.; Bäckerholm, A.; Tian, Y.; Xie, G.; Tang, K.-W.

10.1101/2021.02.07.430139 — bioinformatics — Posted on 2021-02-08

3145 Unsupervised selection of optimal single-molecule time series idealization criterion

Bandyopadhyay, A.; Goldschen-Ohm, M. P.

10.1101/2021.02.07.430124 — bioinformatics — Posted on 2021-02-08

3146 Genome wide mapping of DNA lesions by Repair Assisted Damage Detection sequencing - RADD-Seq

Gilat, N.; Fridman, D.; Sharim, H.; Margalit, S.; Gassman, N.; Michaeli, Y.; Ebenstein, Y.

10.1101/2021.02.07.430183 — genomics — Posted on 2021-02-08

3147 Phylogeny of the damselfishes (Pomacentridae) and patterns of asymmetrical diversification in body size and feeding ecology

McCord, C. L.; Cooper, W. J.; Nash, C. M.; Westneat, M. W.

10.1101/2021.02.07.430149 — evolutionary biology — Posted on 2021-02-08

3148 A theory of evolutionary dynamics on any complex spatial structure

Kuo, Y. P.; Nombela-Arrieta, C.; Carja, O.

10.1101/2021.02.07.430151 — evolutionary biology — Posted on 2021-02-08

3149 Leaf economics explained by optimality principles

Wang, H.; Prentice, I. C.; Wright, I. J.; Qiao, S.; Xu, X.; Kikuzawa, K.; Stenseth, N. C.

10.1101/2021.02.07.430028 — ecology — Posted on 2021-02-08

3150 Selection and structural characterisation of anti-TREM2 scFvs that reduce levels of shed ectodomain

Szykowska, A.; Chen, Y.; Smith, T. B.; Preger, C.; Yang, J.; Qian, D.; Mukhopadhyay, S.; Wigren, E.; Neame, S. J.; Gräslund, S.; Persson, H.; Atkinson, P. J.; Di Daniel, E.; Mead, E.; Wang, J.; Davis, J. B.; Burgess-Brown, N. A.; Bullock, A. N.

10.1101/2021.02.07.430123 — molecular biology — Posted on 2021-02-08

3151 Nucleosomal Asymmetry Shapes Histone Mark Binding and Promotes Poising at Bivalent Domains

Bryan, E.; Warburton, M.; Webb, K. M.; McLaughlin, K. A.; Spanos, C.; Ambrosi, C.; Major, V.; Baubec, T.; Rappsilber, J.; Voigt, P.

10.1101/2021.02.08.430127 — molecular biology — Posted on 2021-02-08

3152 c-MAF dependent perivascular macrophages regulate diet induced metabolic syndrome

Moura Silva, H.; Kitoko, J. Z.; Queiroz, C. P.; Kroehling, L.; Matheis, F.; Lu Yang, K.; Ren-Fielding, C.; Littman, D.; Bozza, M.; Mucida, D.; Lafaille, J.

10.1101/2021.02.07.430147 — immunology — Posted on 2021-02-08

3153 Impact of Propionic Acidemia on Brain Astrocytes

Cotrina, M. L.; Sun, W.; Chen, M. J.; Guenzel, A. J.; Zhagnay, J.; Goldman, J.; Barry, M.; Nedergaard, M.

10.1101/2021.02.07.428966 — neuroscience — Posted on 2021-02-08

3154 Chronic paternal morphine exposure increases sensitivity to morphine-derived antinociception

Toussaint, A. B.; Foster, W.; Jones, J. M.; Kaufmann, S.; Wachira, M.; Hughes, R.; Bongiovanni, A. R.; Famularo, S. T.; Dunham, B. P.; Schwark, R.; Fried, N. T.; Wimmer, M.; Abdus-Saboor, I.

10.1101/2021.02.07.430143 — neuroscience — Posted on 2021-02-08

3155 Genomic analyses of 10,376 individuals provides comprehensive map of genetic variations, structure and reference haplotypes for Chinese population

Cong, P.; Bai, W.; Li, J.; Li, N.; Gai, S.; Khederzadeh, S.; Liu, Y.; Qiu, M.; Zhu, X.; Zhao, P.; Xia, J.; Yu, S.; Zhao, W.; Liu, J.; Guan, P.; Qian, Y.; Tao, J.; Yang, M.; Tian, G.; Xie, S.; Liu, K.; Tang, B.; Zheng, H.

10.1101/2021.02.06.430086 — genetics — Posted on 2021-02-08

3156 Human RNA Nm-MTase FTSJ1: new tRNA targets and role in the regulation of brain-specific genes.

DIMITROVA, D. G.; BRAZANE, M.; TAO, Y.; MARCHAND, V.; SCHAEFER, E.; STARK, Z.; DELATYCKI, M.; DUDDING, T.; GECZ, J.; TEYSSET, L.; PITON, A.; MOTORIN, Y.; CARRE, C.

10.1101/2021.02.06.430044 — genetics — Posted on 2021-02-08

3157 Strain dynamics of specific contaminant bacteria modulate the performance of ethanol biorefineries

Lino, F. S. d. O.; Misiakou, M.-A.; Kang, K.; Li, S.; da Costa, B. L. V.; Basso, T. O.; Panagiotou, G.; Sommer, M. O. A.

10.1101/2021.02.07.430133 — microbiology — Posted on 2021-02-08

3158 The landscape of high-affinity human antibodies against intratumoral antigens

Rakocevic, G.; Gotlova, I.; de Santiago, I.; Toptas, B. C.; Popovic, M.; Popovic, M.; Leone, D. A.; Stachyra, A. L.; Kural, D.; Biasci, D.

10.1101/2021.02.06.430058 — immunology — Posted on 2021-02-08

3159 Spatial transcriptomics reveals unique molecular fingerprints of human nociceptors

Tavares-Ferreira, D.; Shiers, S.; Ray, P.; Wangzhou, A.; Jeevakumar, V.; Sankaranarayanan, I.; Chamessian, A.; Copits, B.; Dougherty, P. M.; Gereau, R.; Burton, M. D.; Dussor, G.; Price, T. J.

10.1101/2021.02.06.430065 — neuroscience — Posted on 2021-02-08

3160 CASTLE: A database of synthetic lethal sets predicted from genome-scale metabolic networks

Senthamizhan, V.; Subramaniam, S.; Raghavan, A.; Raman, K.

10.1101/2021.02.08.430024 — systems biology — Posted on 2021-02-08

3161 Efficient gradient-based parameter estimation for dynamic models using qualitative data

Schmiester, L.; Weindl, D.; Hasenauer, J.

10.1101/2021.02.06.430039 — systems biology — Posted on 2021-02-08

3162 A structured reflective process supports student awareness of employability skills development in a science placement module

Mello, L. V.; Varga-Atkins, T.; Edwards, S. W.

10.1101/2021.02.07.430108 — scientific communication and education — Posted on 2021-02-08

3163 Dynamic Gene-Based Ecophysiological Models to Predict Phenotype from Genotype and Environment Data

Vallejos, C. E.; Jones, J. W.; Bhakta, M. S.; Gezan, S. A.; Correll, M. J.

10.1101/2021.02.07.429927 — plant biology — Posted on 2021-02-08

3164 Enhanced MATE transporter DTX6/PQT15 confers paraquat resistance

Xia, J.-Q.; Xiang, C.

10.1101/2021.02.07.430154 — plant biology — Posted on 2021-02-08

3165 A systematic approach for finding herbicide synergies

Sukhoverkov, K. V.; Mylne, J. S.

10.1101/2021.02.08.430187 — plant biology — Posted on 2021-02-08

3166 Spray-induced gene silencing as a potential tool to control potato late blight disease

Kalyandurg, P. B.; Sundararajan, P.; Dubey, M.; Ghadamgahi, F.; Zahid, M. A.; Whisson, S. C.; Vetukuri, R. R.

10.1101/2021.02.07.430140 — plant biology — Posted on 2021-02-08

3167 Biophysical and proteomic analyses suggest functions of Pseudomonas syringae pv tomato DC3000 extracellular vesicles in bacterial growth during plant infection

Janda, M.; Ludwig, C.; Rybak, K.; Meng, C.; Stigliano, E.; Botzenhardt, L.; Szulc, B.; Sklenar, J.; Menke, F. L. H.; Malone, J. G.; Brachmann, A.; Klingl, A.; Robatzek, S.

10.1101/2021.02.08.430144 — plant biology — Posted on 2021-02-08

3168 An MILP Model for Corn Planting and Harvest Scheduling Considering Storage Capacity and Growing Degree Units

Khalilzadeh, Z.; Wang, L.

10.1101/2021.02.06.430062 — bioinformatics — Posted on 2021-02-08

3169 Precise, Fast and Comprehensive Analysis of Intact Glycopeptides and Monosaccharide-Modifications with pGlyco3

Zeng, W.-F.; Cao, W.-Q.; Liu, M.-Q.; He, S.-M.; Yang, P.-Y.

10.1101/2021.02.06.430063 — bioinformatics — Posted on 2021-02-08

3170 A data-driven method to learn a jump diffusion process from aggregate biological gene expression data

Gao, J.-X.; Wang, Z.-Y.; Zhang, M. Q.; Qian, M.-P.; Jiang, D.-Q.

10.1101/2021.02.06.430082 — bioinformatics — Posted on 2021-02-08

3171 A water-reward task assay for evaluating mouse mutualistic cooperative behavior

Feng, W.; Zhang, Y.; Wang, Z.; Wang, T.; Pang, Y.; Zou, Y.; Huang, H.; Sheng, C.; Xiao, M.

10.1101/2021.02.06.430037 — animal behavior and cognition — Posted on 2021-02-08

3172 The role of claw colouration in fiddler crabs' mate choice: Private communication channel or handicap?

Silva, D. J. A.; Erickson, M. F.; Guidi, R. d. S.; Pessoa, D. M. A.

10.1101/2021.02.06.430085 — animal behavior and cognition — Posted on 2021-02-08

3173 A clonal fresh water plants acquires transgenerational stress resistance under recurring copper excess

Huber, M.; Gablenz, S.; Hoefer, M.

10.1101/2021.02.06.430033 — ecology — Posted on 2021-02-08

3174 Comparative reproductive biology of deep-sea ophiuroids inhabiting polymetallic-nodule fields in the Clarion-Clipperton Fracture Zone

Laming, S. R.; Christodoulou, M.; Arbizu, P. M.; Hilario, A.

10.1101/2021.02.06.428832 — ecology — Posted on 2021-02-08

3175 Trophic resources of the edaphic mesofauna: a worldwide review of the empirical evidence

Velazco, V. N.; Saravia, L. A.; Coviella, C. E.; Falco, L. B.

10.1101/2021.02.06.430061 — ecology — Posted on 2021-02-08

3176 A long-term conservation benefit of protected areas in stochastic population dynamics

Takashina, N.

10.1101/2021.02.06.430090 — ecology — Posted on 2021-02-08

3177 Cell Type Hierarchy Reconstruction via Reconciliation of Multi-resolution Cluster Tree

Peng, M.; Wamsley, B.; Elkins, A. G.; Geschwind, D. M.; Wei, Y.; Roeder, K.

10.1101/2021.02.06.430067 — cell biology — Posted on 2021-02-08

3178 Comparison analysis on transcriptomic of different human trophoblast development model

Liu, Y.; Guo, Y.; Gao, Y.; Hu, G.; Ren, J.; Ma, J.; Cui, J.

10.1101/2021.02.06.430084 — cell biology — Posted on 2021-02-08

3179 Overexpressed microrna-129-5p reverses CCl4-Induced hepatic fibrosis by suppressing PEG3 expression and the NF-κB signaling pathway

Li, Y.; Sun, S.; Ma, Y.

10.1101/2020.11.27.401356 — pharmacology and toxicology — Posted on 2021-02-08

3180 Speciation across the Earth driven by global cooling in orchidoid orchids

Thompson, J. B.; Dodd, H. O.; Wills, M. A.; Priest, N. K.

10.1101/2021.02.06.430029 — evolutionary biology — Posted on 2021-02-08

3181 Disentangling the effects of climate change, landscape heterogeneity, and scale on phenological metrics

Newman, E. A.; Breckheimer, I. K.; Park, D. S.

10.1101/2021.02.05.429398 — ecology — Posted on 2021-02-08

3182 Innovations to expand drone data collection and analysis for rangeland monitoring

Gillan, J.; Ponce-Campos, G. E.; Swetnam, T. L.; Gorlier, A.; Heilman, P.; McClaran, M. P.

10.1101/2021.02.05.430004 — ecology — Posted on 2021-02-08

3183 Pupil Size Reflects Exploration and Exploitation in Visual Search (and It's Like Object-Based Attention)

Regnath, F.; Mathot, S.

10.1101/2021.02.05.429946 — neuroscience — Posted on 2021-02-08

3184 Lesion site and therapy time predict responses to a therapy for anomia after stroke: a prognostic model development study

Hope, T. M. H.; Nardo, D.; Holland, R.; Ondobaka, S.; Akkad, H.; Price, C. J.; Leff, A.; Crinion, J.

10.1101/2021.02.05.429894 — neuroscience — Posted on 2021-02-08

3185 Memory destabilization during reconsolidation - A consequence of homeostatic plasticity?

Amorim, F. E.; Chapot, R. L.; Moulin, T. C.; Lee, J.; Amaral, O. B.

10.1101/2021.02.05.429950 — neuroscience — Posted on 2021-02-08

3186 Exploring the dynamic mechanisms of steady-state visual evoked potentials at the whole-brain level: evidence from a computational study

Zhang, G.; Cui, Y.; Zhang, Y.; Cao, H.; Zhou, G.; Shu, H.; Yao, D.; Xia, Y.; Chen, K.; Guo, D.

10.1101/2021.02.05.429877 — neuroscience — Posted on 2021-02-08

3187 Objective pupillometry shows that perceptual styles covary with autistic-like personality traits

Tortelli, C.; Turi, M.; Burr, D. C.; Binda, P.

10.1101/2021.02.05.429964 — neuroscience — Posted on 2021-02-08

3188 The human visual system preserves the hierarchy of 2-dimensional pattern regularity

Kohler, P. J.; Clarke, A. D. F.

10.1101/2021.02.05.429884 — neuroscience — Posted on 2021-02-08

3189 Reducing the efforts to create reproducible analysis code with FieldTrip

van Es, M. W. J.; Spaak, E.; Schoffelen, J.-M.; Oostenveld, R.

10.1101/2021.02.05.429886 — neuroscience — Posted on 2021-02-08

3190 A recurrent cortical model can parsimoniously explain the effect of expectations on sensory processes

Urgen, B. M.; Boyaci, H.

10.1101/2021.02.05.429913 — neuroscience — Posted on 2021-02-08

3191 The effect of pulse width on the dynamics of pulse-coupled oscillators

Afifurrahman, ; Ullner, E.; Politi, A.

10.1101/2021.02.06.430000 — neuroscience — Posted on 2021-02-08

3192 Emergence of Probabilistic Representation in the Neural Network of Primary Visual Cortex

Li, A. A.; Wang, F.; Zhang, X.; Wu, S.

10.1101/2021.02.06.429971 — neuroscience — Posted on 2021-02-08

3193 Neuronal modulation in the mouse superior colliculus during covert visual selective attention

Wang, L.; Herman, J. P.; Krauzlis, R. J.

10.1101/2021.02.05.429996 — neuroscience — Posted on 2021-02-08

3194 Derived loss of signal complexity and plasticity in a genus of weakly electric fish

Saenz, D. E.; Gu, T.; Ban, Y.; Winemiller, K. O.; Markham, M. R.

10.1101/2021.02.06.430027 — physiology — Posted on 2021-02-08

3195 A Network Propagation Approach to Prioritize Long Tail Genes in Cancer

Mohsen, H.; Gunasekharan, V.; Qing, T.; Negahban, S.; Szallasi, Z.; Pusztai, L.; Gerstein, M.

10.1101/2021.02.05.429983 — bioinformatics — Posted on 2021-02-08

3196 ORFhunteR: an accurate approach for the automatic identification and annotation of open reading frames in human mRNA molecules

Grinev, V. V.; Yatskou, M. M.; Skakun, V. V.; Chepeleva, M. K.; Nazarov, P. V.

10.1101/2021.02.05.429963 — bioinformatics — Posted on 2021-02-08

3197 Large-scale tandem mass spectrum clustering using fast nearest neighbor searching

Bittremieux, W.; Laukens, K.; Noble, W. S.; Dorrestein, P. C.

10.1101/2021.02.05.429957 — bioinformatics — Posted on 2021-02-08

3198 An Incrementally Updatable and Scalable System for Large-Scale Sequence Search using LSM Trees

Almodaresi, F.; Khan, J.; Madaminov, S.; Pandey, P.; Ferdman, M.; Johnson, R.; Patro, R.

10.1101/2021.02.05.429839 — bioinformatics — Posted on 2021-02-08

3199 Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor

Xu, H. E.; Zhuang, Y.; Krumm, B.; Zhang, H.; Zhou, X. E.; Wang, Y.; Huang, X.-P.; Liu, Y.; Cheng, X.; Jiang, Y.; Jiang, H.; Zhang, C.; Yi, W.; Roth, B. L.; Zhang, Y.

10.1101/2021.02.07.430101 — molecular biology — Posted on 2021-02-08

3200 Modulating the left inferior frontal cortex by task domain, cognitive challenge and tDCS

Nardo, D.; Pappa, K.; Duncan, J.; Zeidman, P.; Callaghan, M.; Leff, A.; Crinion, J.

10.1101/2021.02.05.429968 — neuroscience — Posted on 2021-02-08

3201 Bacterium-Enabled Transient Gene Activation by Artificial Transcription Factor for Resolving Gene Regulation in Maize

Zhao, M.; Peng, Z.; Qin, Y.; Zhang, L.; Tian, B.; Chen, Y.; Liu, Y.; Lin, G.; Zheng, H.; He, C.; Lv, K.; Trick, H. N.; Liu, Y.; Cho, M.-J.; Park, S.; Wei, H.; Zheng, J.; White, F. F.; Liu, S.

10.1101/2021.02.05.429970 — plant biology — Posted on 2021-02-08

3202 Structural and functional elucidation of NF-κB signaling by the p75 neurotrophin receptor through recruitment of TRADD

Zhang, N.; Kisiswa, L.; Ramanujan, A.; Li, Z.; Sim, E. W.; Yuan, W.; Ibanez, C. F.; LIN, Z.

10.1101/2021.02.07.430167 — biophysics — Posted on 2021-02-08

3203 Paip2 associates with PABPC1 on mRNA, and may facilitate PABPC1 dissociation from mRNA upon deadenylation

Xie, J.; Wei, X.; Kozlov, G.; Chen, Y.; Menade, M.; Gehring, K.

10.1101/2021.02.07.430161 — biochemistry — Posted on 2021-02-08

3204 Loss of PABPC1 is compensated by elevated PABPC4 and correlates with transcriptome changes

Xie, J.; Wei, X.; Chen, Y.; Gehring, K.

10.1101/2021.02.07.430165 — biochemistry — Posted on 2021-02-08

3205 A non-structural pure enzyme protein forms an LCST type of stimuli-responsive and reversible hydrogel with novel structure and catalytic activity

Nie, J.; Zhang, X.; Liu, Y.; Schroer, M.; Wang, W.; Ren, J.; Svergun, D. I.; Zeng, A.-P.

10.1101/2021.02.07.430034 — biochemistry — Posted on 2021-02-08

3206 Plasmodium falciparum Kelch13 and its artemisinin-resistant mutants assemble as hexamers in solution: a SAXS data driven shape restoration study.

Goel, N.; Dhiman, K.; Kalidas, N.; Mukhopadhyay, A.; Ashish, F.; Bhattacharjee, S.

10.1101/2021.02.07.430181 — biochemistry — Posted on 2021-02-08

3207 Poly(A) binding protein is required for mRNP remodeling to form P-bodies in mammalian cells

Xie, J.; Chen, Y.; Wei, X.; Kozlov, G.; Gehring, K.

10.1101/2021.02.07.430159 — biochemistry — Posted on 2021-02-08

3208 Ethanol-guided behavior in Drosophila larvae

Schumann, I.; Berger, M.; Nowag, N.; Schaefer, Y.; Saumweber, J.; Scholz, H.; Thum, A. S.

10.1101/2021.02.07.430116 — animal behavior and cognition — Posted on 2021-02-08

3209 Social selection is density dependent but makes little contribution to total selection in New Zealand giraffe weevils

Fisher, D. N.; LeGrice, R. J.; Painting, C. J.

10.1101/2021.02.06.430048 — evolutionary biology — Posted on 2021-02-08

3210 POGZ controls embryonic stem cell self-renewal and pluripotency by association with esBAF and HP1

sun, y.; Sun, X.; Cheng, l.

10.1101/2021.02.07.430173 — developmental biology — Posted on 2021-02-08

3211 Bidirectional neuronal migration coordinates retinal morphogenesis bypreventing spatial competition

Rocha-Martins, M.; Kretzschmar, J.; Nerli, E.; Weigert, M.; Icha, J.; Myers, E. W.; Norden, C.

10.1101/2021.02.08.430189 — developmental biology — Posted on 2021-02-08

3212 Impact of cobas PCR Media Freezing on SARS-CoV-2 Viral RNA Integrity and Whole Genome Sequencing Analyses

Benoit, P.; Point, F.; Gagnon, S.; Kaufmann, D. E.; Tremblay, C.; Harrigan, P. R.; Hardy, I.; Coutlee, F.; Grandjean Lapierre, S.

10.1101/2021.02.05.430022 — molecular biology — Posted on 2021-02-08

3213 The ability of Pseudomonas aeruginosa to adopt a Small Colony Variant (SCV) phenotype is conserved, and not restricted to clinical isolates

Besse, A.; Trottier, M.; Groleau, M.-C.; Deziel, E.

10.1101/2021.02.05.430018 — microbiology — Posted on 2021-02-08

3214 Loss of ClpP Function in Clostridioides difficile 630 Significantly Impacts Sporulation Systems

Bishop, C. E.; Shadid, T.; Lavey, N. P.; Kempher, M. L.; Ahsan, N.; Ballard, J. D.; Duerfeldt, A. S.

10.1101/2021.02.05.429978 — microbiology — Posted on 2021-02-08

3215 Recombinant chimpanzee adenovirus AdC7 expressing dimeric tandem-repeat RBD of SARS-CoV-2 spike protein protects mice against COVID-19

Xu, K.; An, Y.; Li, Q.; Huang, W.; Han, Y.; Zheng, T.; Fang, F.; Liu, H.; Liu, C.; Gao, P.; Xu, S.; Liu, W. J.; Bi, Y.; Wang, Y.; Zhou, D.; Wang, Q.; Hou, W.; Xia, Q.; Gao, G. F.; Dai, L.

10.1101/2021.02.05.429860 — immunology — Posted on 2021-02-08

3216 Neuronal activity promotes nuclear proteasome-mediated degradation of PDCD4 to regulate activity-dependent transcription

Herbst, W. A.; Deng, W.; Wohlschlegel, J. A.; Achiro, J. M.; Martin, K. C.

10.1101/2021.02.06.429040 — neuroscience — Posted on 2021-02-08

3217 Leaky wiring of the brain: local cluster of coupled synapses and extracellular signal integration

Dietrich, D.; Matthews, E.; Sun, W.; McMahon, S.; Döngi, M.; Halka, L.; Anders, S.; Müller, J. A.; Steinlein, P.; Vana, N.; van Dyk, G.; Pitsch, J.; Becker, A. J.; Pfeifer, A.; Kavalali, E. T.; Lamprecht, A.; Henneberger, C.; Stein, V.; Schoch, S.

10.1101/2021.02.05.429974 — neuroscience — Posted on 2021-02-08

3218 Human spinal cord differentiation proceeds rapidly in vitro and only initially maintains differentiation pace in a heterologous environment

Dady, A.; Davidson, L.; Halley, P. A.; Storey, K. G.

10.1101/2021.02.06.429972 — developmental biology — Posted on 2021-02-08

3219 Transcriptomic and genetic analyses identify the Kruppel-like factor dar1 as a master regulator of tube-shaped long tendon development

Laurichesse, Q.; Moucaud, B.; Jagla, K.; soler, c.

10.1101/2021.02.07.430104 — developmental biology — Posted on 2021-02-08

3220 Tick infestation probability increases with human recreation and exploratory behaviour in great tits

Rollins, R. E.; Mouchet, A.; Margos, G.; Fingerle, V.; Becker, N. S.; Dingemanse, N. J.

10.1101/2020.03.06.978973 — ecology — Posted on 2021-02-08

3221 Cholesterol recognition motifs in the transmembrane domain of the tyrosine kinase receptor family: the case for TRKB

Cannarozzo, C.; Fred, S. M.; Girych, M.; Biojone, C.; Enkavi, G.; Rog, T.; Vattulainen, I.; Casarotto, P. C.; Castren, E.

10.1101/734012 — neuroscience — Posted on 2021-02-08

3222 Brain expressed FKBP5 delineates a therapeutic subtype of severe mental illness

Matosin, N.; Arloth, J.; Martinelli, S.; Czamara, D.; Maitra, M.; Halldorsdottir, T.; Cruceanu, C.; Kaul, D.; Gassen, N.; Hafner, K.; Mueller, N.; Worf, K.; Rehawi, G.; Nagy, C.; Scarr, E.; Tao, R.; Jaffe, A. E.; Arzberger, T.; Falkai, P.; Kleinmann, J.; Weinberger, D.; Mechawar, N.; Schmitt, A.; Dean, B.; Turecki, G.; Hyde, T. M.; Binder, E.

10.1101/2021.01.27.428487 — neuroscience — Posted on 2021-02-08

3223 Ultra-high sensitivity mass spectrometry quantifies single-cell proteome changes upon perturbation

Brunner, A.-D.; Thielert, M.; Vasilopoulou, C.; Ammar, C.; Coscia, F.; Mund, A.; Horning, O. B.; Bache, N.; Apalategui, A.; Lubeck, M.; Raether, O.; Park, M.; Richter, S.; Fischer, D. S.; Meier, F.; Theis, F. J.; Mann, M.

10.1101/2020.12.22.423933 — systems biology — Posted on 2021-02-08

3224 Formation of synthetic RNP granules using engineered phage-coat-protein -RNA complexes

Granik, N.; Katz, N.; Goldberg, S.; Amit, R.

10.1101/682518 — biophysics — Posted on 2021-02-08

3225 Combinatorial approach of binary colloidal crystals (BCCs) and CRISPR activation to improve induced pluripotent stem cell differentiation into neurons

Urrutia-Cabrera, D.; Liou, R. H.-C.; Lin, J.; Liu, K.; Hung, S. S.-C.; Hewitt, A. W.; Wang, P.-Y.; Wong, R. C.-B.

10.1101/2020.12.21.423852 — bioengineering — Posted on 2021-02-08

3226 The Memory for Latent Representations: An Account of Working Memory that Builds on Visual Knowledge for Efficient and Detailed Visual Representations

Hedayati, S.; O'Donnell, R.; Wyble, B.

10.1101/2021.02.07.430171 — neuroscience — Posted on 2021-02-07

3227 High coverage whole genome sequencing of the expanded 1000 Genomes Project cohort including 602 trios

Byrska-Bishop, M.; Evani, U. S.; Zhao, X.; Basile, A. O.; Abel, H. J.; Regier, A. A.; Corvelo, A.; Clarke, W. E.; Musunuri, R.; Nagulapalli, K.; Fairley, S.; Runnels, A.; Winterkorn, L.; Lowy-Gallego, E.; The Human Genome Structural Variation Consortium, ; Flicek, P.; Germer, S.; Brand, H.; Hall, I. M.; Talkowski, M. E.; Narzisi, G.; Zody, M. C.

10.1101/2021.02.06.430068 — genomics — Posted on 2021-02-07

3228 Deep learning integration of molecular and interactome data for protein-compound interaction prediction

Watanabe, N.; Ohnuki, Y.; Sakakibara, Y.

10.1101/2021.01.31.429000 — bioinformatics — Posted on 2021-02-07

3229 Optical regulation of endogenous RhoA reveals switching of cellular responses by signal amplitude

Ju, J.; Ning, L.; Lee, H. N.; Chun, H.; Zhou, X. X.; Ryu, H.; Lee, Y. W.; Lee-Richerson, A. I.; Jeong, C.; Lin, M.; Seong, J.

10.1101/2021.02.05.430013 — bioengineering — Posted on 2021-02-07

3230 Multi-omic characterization of the thermal stress phenome in the stony coral Montipora capitata

Pathmanathan, J.; Williams, A.; Stephens, T. G.; Su, X.; Chiles, E. N.; Conetta, D.; Putnam, H. M.; Bhattacharya, D.

10.1101/2021.02.05.429981 — genomics — Posted on 2021-02-07

3231 Self-assembling SARS-CoV-2 nanoparticle vaccines targeting the S protein induces protective immunity in mice

Liu, X.; Song, H.; Jiang, J.; Gao, X.; Yi, Y.; Shang, Y.; Li, J.; Li, D.; Zeng, Z.; Li, Y.; Zhang, Z.

10.1101/2021.02.05.428685 — immunology — Posted on 2021-02-07

3232 Somatostatin-positive Interneurons Contribute to Seizures in SCN8A Epileptic Encephalopathy

Wengert, E. R.; Wedgwood, K. C.; Wagley, P. K.; Strohm, S. M.; Panchal, P. S.; Idrissi, A. M.; Wenker, I. C.; Gaykema, R. P.; Patel, M. K.

10.1101/2021.02.05.429987 — neuroscience — Posted on 2021-02-07

3233 Neuronal Switching Between Single- and Dual-Network Activity via Modulation of Intrinsic Membrane Properties

Fahoum, S.-R. H.; Blitz, D. M.

10.1101/2021.02.05.429848 — neuroscience — Posted on 2021-02-07

3234 Information Content Differentiates Enhancers From Silencers in Mouse Photoreceptors

Friedman, R. Z.; Granas, D. M.; Myers, C. A.; Corbo, J. C.; Cohen, B. A.; White, M. A.

10.1101/2021.02.05.429997 — systems biology — Posted on 2021-02-07

3235 Whole Animal Multiplexed Single-Cell RNA-Seq Reveals Plasticity of Clytia Medusa Cell Types

Chari, T.; Weissbourd, B.; Gehring, J.; Ferraioli, A.; Leclere, L.; Herl, M.; Gao, F.; Chevalier, S.; Copley, R. R.; Houliston, E.; Anderson, D. J.; Pachter, L.

10.1101/2021.01.22.427844 — systems biology — Posted on 2021-02-07

3236 Rational Design of Programmable Monodisperse Semi-Synthetic Protein Nanomaterials Containing Engineered Disulfide Functionality

Bhandari, P. J.; Sandanaraj, B. S.

10.1101/2021.02.05.430015 — synthetic biology — Posted on 2021-02-07

3237 Randomized controlled studies comparing traditional lectures versus online modules

Musunuru, K.; Machanda, Z. P.; Qiao, L.; Anderson, W. J.

10.1101/2021.01.18.427113 — scientific communication and education — Posted on 2021-02-07

3238 Tissue-type specific accumulation of the plastoglobular proteome, transcriptional networks and plastoglobular functions

Michel, E. J. S.; Ponnala, L.; van Wijk, K. J.

10.1101/2021.02.05.430006 — plant biology — Posted on 2021-02-07

3239 The role of IL-1 in adipose browning and muscle wasting in CKD-associated cachexia

Cheung, W. W.; Zheng, R.; Hao, S.; Wang, Z.; Gonzalez, A.; Zhou, P.; Hoffman, H. M.; Mak, R. H.

10.1101/2021.02.05.429984 — physiology — Posted on 2021-02-07

3240 Elephant seal muscle cells adapt to sustained glucocorticoid exposure by shifting their metabolic phenotype

Torres-Velarde, J. M.; Kolora, S. R. R.; Khudyakov, J. I.; Crocker, D. E.; Sudmant, P. H.; Vazquez-Medina, J. P.

10.1101/2021.02.05.429992 — physiology — Posted on 2021-02-07

3241 The hepatocyte insulin receptor is required to program rhythmic gene expression and the liver clock

Fougeray, T.; Polizzi, A.; Regnier, M.; Fougerat, A.; Ellero-Simatos, S.; Lippi, Y.; Smati, S.; Lasserre, F.; Tramunt, B.; Huillet, M.; Dopavogui, L.; Smith, L.; Naylies, C.; Sommer, C.; Benani, A.; Haas, J. T.; Wahli, W.; Duez, H.; Gourdy, P.; Gamet-Payrastre, L.; Burnol, A.-F.; Loiseau, N.; Postic, C.; Montagner, A.; Guillou, H.

10.1101/2021.02.05.430014 — physiology — Posted on 2021-02-07

3242 Cardiac and behavioural responses to hypoxia and warming in free-swimming gilthead seabream Sparus aurata

Mignucci, A.; Bourjea, J.; Forget, F.; Allal, H.; Dutto, G.; Gasset, E.; McKenzie, D. J.

10.1101/2021.02.05.429945 — physiology — Posted on 2021-02-07

3243 Redefining tumor classification and clinical stratification through a colorectal cancer single-cell atlas

10.1101/2021.02.02.429256 — cancer biology — Posted on 2021-02-07

3244 Standardizing a protocol for studying pH-dependent transient conformations using computer simulations

Singh, R.; Lynn, A. M.

10.1101/2020.12.21.423456 — bioinformatics — Posted on 2021-02-07

3245 VeloSim: Simulating single cell gene-expression and RNA velocity

Zhang, Z.; Zhang, X.

10.1101/2021.01.11.426277 — bioinformatics — Posted on 2021-02-07

3246 Brain transcriptomic changes in Japanese quail reveal roles for neurotensin and urocortin 3 in avian parental care

Lopes, P. C.; de Bruijn, R.

10.1101/2020.11.29.401794 — animal behavior and cognition — Posted on 2021-02-07

3247 DLX5/6 GABAergic expression affects social vocalization: implications for human evolution

Levi, G.; de Lombares, C.; Giuliani, C.; Iannuzzi, V.; Aouci, R.; Garagnani, P.; Franceschi, C.; Grimaud-Herve, D.; Narboux-Neme, N.

10.1101/2020.07.24.218065 — evolutionary biology — Posted on 2021-02-07

3248 Predicted distribution of a rare and understudied forest carnivore: Humboldt martens (Martes caurina humboldtensis)

Moriarty, K. M.; Thompson, J.; Delheimer, M. S.; Barry, B. R.; Linnell, M. A.; Levi, T.; Hamm, K.; Early, D.; Gamblin, H.; Szykman Gunther, M.; Ellison, J. L.; Prevey, J.; Hartman, J.; Davis, R.

10.1101/2021.02.05.429381 — ecology — Posted on 2021-02-07

3249 β-Catenin and canonical Wnts control two separate pattern formation systems in Hydra: Insights from mathematical modelling

Mercker, M.; Lengfeld, T.; Höger, S.; Tursch, A.; Lommel, M.; Holstein, T. W.; Marciniak-Czochra, A.

10.1101/2021.02.05.429954 — developmental biology — Posted on 2021-02-07

3250 Estimation of differential cell cycle kinetics in higher plant root meristem with cellular fate and positional resolution.

Pasternak, T. P.; Kircher, S.; Palme, K.

10.1101/2021.01.01.425043 — cell biology — Posted on 2021-02-07

3251 Resolving the conflict between antibiotic production and rapid growth by recognition of peptidoglycan of susceptible competitors

Maan, H.; Friedman, J.; Kolodkin-Gal, I.

10.1101/2021.02.07.430110 — microbiology — Posted on 2021-02-07

3252 Molecular and cellular insight into Escherichia coli SslE and its role during biofilm maturation

Corsini, P.; Wang, S.; Rehman, S.; Fenn, K.; Sagar, A.; Sirovica, S.; Cleaver, L.; Dorgan, B.; Sewell, L. M.; Lynham, S.; Jarvis, J.; Carpenter, G.; Curtis, M. A.; Bernado, P.; Darbari, V. C.; Garnett, J. A.

10.1101/2021.02.07.430137 — microbiology — Posted on 2021-02-07

3253 Differential optogenetic excitation of the auditory midbrain in freely moving behaving mice

Rogalla, M. M.; Seibert, A.; Hildebrandt, K. J.

10.1101/2021.02.05.429951 — neuroscience — Posted on 2021-02-07

3254 Functional ultrasound imaging of the spreading activity following optogenetic stimulation of the rat visual cortex

Provansal, M.; Labernede, G.; Joffrois, C.; Rizkallah, A.; Goulet, R.; Valet, M.; Deschamps, W.; Ferrari, U.; Chaffiol, A.; Dalkara, D.; Sahel, J.-A.; Tanter, M.; Picaud, S.; Gauvain, G.; Arcizet, F.

10.1101/2021.02.05.429985 — neuroscience — Posted on 2021-02-07

3255 Transsynaptic N-cadherin adhesion complexes control presynaptic vesicle and bulk endocytosis at physiological temperature

Dagar, S.; Gottmann, K.

10.1101/2021.02.05.429924 — neuroscience — Posted on 2021-02-07

3256 C-bouton components on rat extensor digitorum longus motoneurons are resistant to chronic functional overload

Kissane, R. W.; Ghaffari-Rafi, A.; Tickle, P. G.; Chakrabarty, S.; Egginton, S.; Brownstone, R. M.; Smith, C. C.

10.1101/2021.02.05.429939 — neuroscience — Posted on 2021-02-07

3257 Targeting interleukin-1 for reversing fat browning and muscle wasting in infantile nephropathic cystinosis

Cheung, W. W.; Hao, S.; Zheng, R.; Wang, Z.; Gonzalez, A.; Zhou, P.; Hoffman, H. M.; Mak, R. H.

10.1101/2021.02.05.429989 — physiology — Posted on 2021-02-07

3258 Zinc-binding motif acts as an oxidative stress sensor to regulate TRPM7 channel activity

Inoue, H.; Murayama, T.; Kobayashi, T.; Konishi, M.; Yokoyama, U.

10.1101/2020.09.28.316125 — physiology — Posted on 2021-02-07

3259 Drug Conjugates of Antagonistic RSPO4 Mutant For Simultaneous Targeting of LGR4/5/6 for Cancer Treatment

Cui, J.; Park, S.; Yu, W. A.; Carmon, K. S.; Liu, Q. J.

10.1101/2021.02.05.429956 — pharmacology and toxicology — Posted on 2021-02-07

3260 Insights on SARS-CoV-2's Mutations for Evading Human Antibodies: Sacrifice and Survival

Luan, B.; Huynh, T.

10.1101/2021.02.06.430088 — biophysics — Posted on 2021-02-07

3261 The local topological free energy of the SARS-CoV-2 Spike protein

Baldwin, Q.; Sumpter, B. G.; Panagiotou, E.

10.1101/2021.02.06.430094 — bioinformatics — Posted on 2021-02-07

3262 epitopepredict: A tool for integrated MHC binding prediction

Farrell, D.

10.1101/2021.02.05.429892 — bioinformatics — Posted on 2021-02-07

3263 Analysis of independent cohorts of outbred CFW mice reveals novel loci for behavioral and physiological traits and identifies factors determining reproducibility

Zou, J.; Gopalakrishnan, S.; Parker, C. C.; Nicod, J.; Mott, R.; Cai, N.; Lionikas, A.; Davies, R. W.; Palmer, A. A.; Flint, J.

10.1101/2021.02.05.429998 — bioinformatics — Posted on 2021-02-07

3264 Differentiable molecular simulation can learn all the parameters in a coarse-grained force field for proteins

Greener, J. G.; Jones, D. T.

10.1101/2021.02.05.429941 — bioinformatics — Posted on 2021-02-07

3265 Densified Collagen Tubular Grafts for Human Tissue Replacement and Disease Modelling Applications

Justin, A. W.; Burgess, S.; Ong, J.; Jacob, A. G.; Sinha, S.; Markaki, A. E.

10.1101/2021.02.05.429744 — bioengineering — Posted on 2021-02-07

3266 A vascularized tumoroid model for studying human glioblastoma angiogenesis

Stavropoulou-Tatla, A.; Justin, A. W.; Watts, C.; Markaki, A. E.

10.1101/2021.02.05.429930 — bioengineering — Posted on 2021-02-07

3267 Exercise Attenuates Sickness Behavior And Protects Against Dopaminergic Impairment Induced By Neuroinflammation

Alves, A. C. d. B.; Staats, A.; Speck, A. E.; Lopes, S. C.; Scheffer, D. d. L.; Melo, H. M.; Prediger, R. D.; Martins, R. d. P.; Latini, A.; Aguiar, A. S.

10.1101/2021.02.05.429925 — animal behavior and cognition — Posted on 2021-02-07

3268 Mendelian Randomization Analysis Using Multiple Biomarkers of an Underlying Common Exposure

Jin, J.; Qi, G.; Yu, Z.; Chatterjee, N.

10.1101/2021.02.05.429979 — genetics — Posted on 2021-02-07

3269 Intraspecific trait changes have large impacts on community functional composition but do not affect ecosystem function

Pichon, N. A.; Cappelli, S. L.; Allan, E.

10.1101/2021.02.05.429745 — ecology — Posted on 2021-02-07

3270 Targeting CTP Synthetase 1 to Restore Interferon Induction and Impede Nucleotide Synthesis in SARS-CoV-2 Infection

Rao, Y.; Wang, T.-Y.; Qin, C.; Espinosa, B.; Liu, Q.; Ekanayake, A.; Zhao, J.; Savas, A. C.; Zhang, S.; Zarinfar, M.; Liu, Y.; Zhu, W.; Graham, N. A.; Jiang, T.; Zhang, C.; Feng, P.

10.1101/2021.02.05.429959 — microbiology — Posted on 2021-02-07

3271 Human immunoglobulin from transchromosomic bovines hyperimmunized with SARS-CoV-2 spike antigen efficiently neutralizes viral variants.

Liu, Z.; Wu, H.; Egland, K. A.; Gilliland, T. C.; Dunn, M. D.; Luke, T. C.; Sullivan, E. J.; Klimstra, W. B.; Bausch, C. L.; Whelan, S. P. J.

10.1101/2021.02.06.430072 — microbiology — Posted on 2021-02-07

3272 Long non-coding RNAs bind to proteins relevant to the ethanol tolerance in yeast: a systems biology view

Marques, L. F.; Wolf, I. R.; Lazari, L. C.; Almeida, L. F. d.; Schnepper, A. P.; Cardoso, L. H.; Moraes, L. N. d.; Grotto, R. M. T.; Simoes, R. P.; Ramos, E.; Valente, G. T.

10.1101/2021.02.07.430053 — microbiology — Posted on 2021-02-07

3273 A human antibody with blocking activity to RBD proteins of multiple SARS-CoV-2 variants including B.1.351 showed potent prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus macaques

Deng, S.-J.; cao, X.; Gu, C.; Wang, Z.; Liu, P.; Liu, X.; Gao, L.; Jia, F.; Yu, L.; Li, N.; Jiang, G.; Zhang, J.; Yang, L.; Shi, M.; Hou, T.; Li, Y.; Liang, W.; Lu, G.; Yang, C.; Wang, Y.; Xia, K.; Xiao, Z.; Xue, J.; Huang, X.; Chen, X.; Pan, Z.; Wang, X.; Guo, H.; Liang, H.; Yao, Y.; Gao, G.; Peng, Y.; Hu, X.; Min, J.; Zhou, Y.; Liu, K.; Guo, W.; Yuan, Z.; Song, D.; Guan, W.; Ma, H.; Hu, X.; Zhang, Y.; Chen, Z.; Shan, C.

10.1101/2021.02.07.429299 — microbiology — Posted on 2021-02-07

3274 Neutralization of viruses with European, South African, and United States SARS-CoV-2 variant spike proteins by convalescent sera and BNT162b2 mRNA vaccine-elicited antibodies

Tada, T.; Dcosta, B. M.; Samanovic-Golden, M.; Herati, R. S.; Cornelius, A.; Mulligan, M. J.; Landau, N. R.

10.1101/2021.02.05.430003 — microbiology — Posted on 2021-02-07

3275 Adaptive maternal effects in early life history traits help to maintain ecological resilience in novel environments for two contrasting Senecio species

Walter, G. M.; du Plessis, S.; Terranova, D.; la Spina, E.; Majorana, M. G.; Pepe, G.; Clark, J.; Cozzolino, S.; Cristaudo, A. E.; Hiscock, S. J.; Bridle, J. R.

10.1101/2021.02.04.429835 — evolutionary biology — Posted on 2021-02-07

3276 Network centrality is the most important variable determining gene sequence evolution rates in Schizosaccharomyces pombe

Harnqvist, S.

10.1101/2021.01.10.426089 — genomics — Posted on 2021-02-07

3277 Experimentally disambiguating models of sensory cue integration

Scarfe, P.

10.1101/2020.09.01.277400 — neuroscience — Posted on 2021-02-07

3278 Single-cell characterization of step-wise acquisition of carboplatin resistance in ovarian cancer

Wenzel, A. T.; Champa, D.; Venkatesh, H.; Sun, S.; Tsai, C.-Y.; Mesirov, J. P.; Bui, J. D.; Howell, S. B.; Harismendy, O.

10.1101/231548 — cancer biology — Posted on 2021-02-07

3279 Strobemers: an alternative to k-mers for sequence comparison

Sahlin, K.

10.1101/2021.01.28.428549 — bioinformatics — Posted on 2021-02-07

3280 Molecular and structural mechanisms of ZZ domain-mediated cargo recognition by autophagy receptor Nbr1

Wang, Y.-Y.; Zhang, J.; Liu, X.-M.; Dong, M.-Q.; Ye, K.; Du, L.-L.

10.1101/2021.02.07.430097 — cell biology — Posted on 2021-02-07

3281 NEDD4 Regulates Ubiquitination and Stability of the Cell adhesion Molecule IGPR-1 via Lysosomal Pathway

Sun, L.; Amraei, R.; Rahimi, N.

10.1101/2021.02.07.430113 — cell biology — Posted on 2021-02-07

3282 Predictive systems biomarkers of response to immune checkpoint inhibitors

Lapuente-Santana, O.; van Genderen, M.; Hilbers, P.; Finotello, F.; Eduati, F.

10.1101/2021.02.05.429977 — cancer biology — Posted on 2021-02-07

3283 Integrative genome-wide analysis reveals EIF3A as a key downstream regulator of translational repressor protein Musashi 2 (MSI2)

Karmakar, S.; Ramirez, O.; Paul, K. V.; Gupta, A. K.; Botti, V.; Mozos, I. R. d. l.; Neuenkirchen, N.; Ross, R. J.; Neugebauer, K. M.; Pillai, M. M.

10.1101/2021.02.06.428911 — cancer biology — Posted on 2021-02-07

3284 Structure of human Nav1.5 reveals the fast inactivation-related segments as a mutational hotspot for the Long QT Syndrome

Li, Z.; Jin, X.; Wu, T.; Zhao, X.; Wang, W.; Lei, J.; Pan, X.; Yan, N.

10.1101/2021.02.06.430010 — biophysics — Posted on 2021-02-07

3285 The Human walking kinematic model combined with upper and lower limb movement

Chen, X.; Hong, B.; Lin, Z.; Hou, J.; Lv, S.; Gao, Z.

10.1101/2021.02.06.430092 — biophysics — Posted on 2021-02-07

3286 Elucidating the Mechanical Energy for Cyclization of a DNA Origami Tile

Li, R.; Chen, H.; Lee, H.; Choi, J. H.

10.1101/2021.02.07.430115 — biophysics — Posted on 2021-02-07

3287 Likelihood-based estimation of substructure content from single-wavelength anomalous diffraction (SAD) intensity data

Hatti, K. S.; McCoy, A. J.; Read, R. J.

10.1101/2021.02.07.430107 — biophysics — Posted on 2021-02-07

3288 HGC: fast hierarchical clustering for large-scale single-cell data

Zou, Z.; Hua, K.; Zhang, X.

10.1101/2021.02.07.430106 — bioinformatics — Posted on 2021-02-07

3289 Ex vivo delivery of regulatory T cells for control of alloimmune priming in the donor lung

Miyamoto, E.; Takahagi, A.; Ohsumi, A.; Martinu, T.; Hwang, D.; Boonstra, K.; Joe, B.; Juan Umana, M.; Bei, K.; Vosoughi, D.; Liu, M.; Cypel, M.; Keshavjee, S.; Juvet, S. C.

10.1101/2021.02.07.430098 — immunology — Posted on 2021-02-07

3290 TNF signalling fine-tunes Langerhans cell transcriptional programmes mediating adaptive immunity.

Davies, J.; Vallejo, A. F.; Sirvent, S.; Porter, G.; Clayton, K.; Qumbelo, Y.; Stumpf, P.; West, J.; Gray, C. M.; Chigorimbo-Murefu, N. T. L.; MacArthur, B.; Polak, M. E.

10.1101/2021.02.07.430111 — systems biology — Posted on 2021-02-07

3291 Long-term persistence of crAss-like phage crAss001 is associated with phase variation in Bacteroides intestinalis

Shkoporov, A. N.; Khokhlova, E. V.; Stephens, N.; Hueston, C.; Seymour, S.; Hryckowian, A. J.; Scholz, D.; Ross, R. P.; Hill, C.

10.1101/2020.12.02.408625 — microbiology — Posted on 2021-02-07

3292 Temporal dynamics of animacy categorization in the brain of patients with mild cognitive impairment

Karimi, H.; Marefat, H.; Khanbagi, M.; Kalafatis, C.; Modarres, M. H.; Vahabi, Z.; Khaligh-Razavi, S.-M.

10.1101/2020.11.20.390435 — neuroscience — Posted on 2021-02-07

3293 Multiple dimensions underlying the functional organisation of the language network

Hodgson, V. J.; Lambon Ralph, M.; Jackson, R. L.

10.1101/2021.02.05.429902 — neuroscience — Posted on 2021-02-07

3294 Expansion of cortical layers 2 and 3 in human left temporal cortex associates with verbal intelligence

Heyer, D. B.; Wilbers, R.; Galakhova, A. A.; Hartsema, E.; Braak, S.; Hunt, S.; Verhoog, M. B.; Muijtjens, M. L.; Mertens, E. J.; Idema, S.; Baayen, J. C.; de Witt Hamer, P. C.; Klein, M.; McGraw, M.; Lein, E. S.; de Kock, C. P. J.; Mansvelder, H. D.; Goriounova, N. A.

10.1101/2021.02.07.430103 — neuroscience — Posted on 2021-02-07

3295 A behavioral syndrome linking boldness and flexibility facilitates invasion success in sticklebacks

Bensky, M.; BELL, A.

10.1101/2021.02.06.430052 — animal behavior and cognition — Posted on 2021-02-07

3296 Huntingtin CAG expansion impairs germ layer patterning in synthetic human gastruloids through polarity defects.

Galgoczi, S.; Ruzo, A.; Markopoulos, C.; Yoney, A.; Phan-Everson, T.; Haremaki, T.; Metzger, J. J.; Etoc, F.; Brivanlou, A. H.

10.1101/2021.02.06.430005 — developmental biology — Posted on 2021-02-07

3297 Piezo2 mediates ultrasonic hearing via cochlear outer hair cells in mice

Li, J.; Liu, S.; Song, C.; Hu, Q.; Zhao, Z.; Deng, T.; Zou, L.; Wang, S.; Chen, J.; Liu, L.; Hou, H.; Yuan, K.; Zheng, H.; Liu, Z.; Chen, X.; Sun, W.; Xiao, B.; Xiong, W.

10.1101/2020.10.09.332643 — neuroscience — Posted on 2021-02-07

3298 Redefining tumor classification and clinical stratification through a colorectal cancer single-cell atlas

10.1101/2021.02.02.429256 — cancer biology — Posted on 2021-02-07

3299 Diverse molecular mechanisms contribute to differential expression of human duplicated genes

Shew, C. J.; Carmona-Mora, P.; Soto, D. C.; Mastoras, M.; Roberts, E.; Rosas, J.; Jagannathan, D.; Kaya, G.; O'Geen, H.; Dennis, M. Y.

10.1101/2020.11.27.401752 — genomics — Posted on 2021-02-07

3300 Heterogeneous recruitment abilities to RNA polymerases generate nonlinear scaling of gene expression level with cell volume

Lin, J.

10.1101/2021.01.26.428201 — genetics — Posted on 2021-02-07

3301 The nucleoid-associated protein Gbn binds to GATC sequences and affects sporulation and antibiotic production in Streptomyces

Du, C.; Willemse, J.; Carrion, V. J.; Erkelens, A. M.; Dame, R. T.; van Wezel, G. P.

10.1101/2021.02.06.430045 — molecular biology — Posted on 2021-02-07

3302 Comparing Methods for Species Tree Estimation With Gene Duplication and Loss

Willson, J.; Roddur, M.; Warnow, T.

10.1101/2021.02.05.429947 — evolutionary biology — Posted on 2021-02-07

3303 Delayed auditory encoding and variable representation of stimulus regularity in cerebellar lesion patients

Schwartze, M.; Kotz, S. A.

10.1101/2021.02.06.430035 — neuroscience — Posted on 2021-02-07

3304 Cortico-subcortical β burst dynamics underlying movement cancellation in humans

Diesburg, D. A.; Greenlee, J. D. W.; Wessel, J. R.

10.1101/2021.02.06.430074 — neuroscience — Posted on 2021-02-07

3305 Temporo-cerebellar connectivity underlies timing constraints in audition

Stockert, A.; Schwartze, M.; Poeppel, D.; Anwander, A.; Kotz, S. A.

10.1101/2021.02.06.430038 — neuroscience — Posted on 2021-02-07

3306 Design of intrinsically disordered proteins that undergo phase transitions with lower critical solution temperatures

Zeng, X.; Liu, C.; Fossat, M. J.; Ren, P.; Chilkoti, A.; Pappu, R. V.

10.1101/2020.11.13.381897 — biophysics — Posted on 2021-02-06

3307 Bayesian Decoder Models with a Discriminative Observation Process

Rezaei, M. R.; Hadjinicolaou, A. E.; Cash, S. S.; Eden, U.; Yousefi, A.

10.1101/2020.07.11.198564 — bioinformatics — Posted on 2021-02-06

3308 Depth Dataset Using Microsoft Kinect-v2

Heravi, H.; Delgarmi, M.; Rahimpour Jounghani, A.; shahrezaie, A.; Ebrahimi, A.; Shamsi, M.

10.1101/2021.02.04.429850 — bioengineering — Posted on 2021-02-06

3309 Nascent polypeptide within the exit tunnel ensures continuous translation elongation by stabilizing the translating ribosome

Chadani, Y.; Sugata, N.; Niwa, T.; Ito, Y.; Iwasaki, S.; Taguchi, H.

10.1101/2021.02.02.429294 — biochemistry — Posted on 2021-02-06

3310 Single-cell RNA-sequencing reveals pre-meiotic X-chromosome dosage compensation in Drosophila testis

Witt, E.; Shao, Z.; Hu, C.; Krause, H. M.; Zhao, L.

10.1101/2021.02.05.429952 — genetics — Posted on 2021-02-06

3311 Aspartate-phobia of thermophiles as a reaction to deleterious chemical transformations

Villain, E.; Fort, P.; Kajava, A. V.

10.1101/2020.08.16.252783 — evolutionary biology — Posted on 2021-02-06

3312 Sex pheromone signal and stability covary with fitness

Blankers, T.; Lievers, R.; Plata, C.; van Wijk, M.; van Veldhuizen, D.; Groot, A. T.

10.1101/2021.02.05.429875 — evolutionary biology — Posted on 2021-02-06

3313 Landscape composition mediates suppression of major pests by natural enemies in conventional cruciferous vegetables

Zhang, J.; You, S.; Niu, D.; Gavilanes Guaman, K. G.; Wang, A.; Saqib, H. S. A.; He, W.; Yu, Y.; Yang, G.; Pozsgai, G.; You, M.

10.1101/2021.02.04.429816 — ecology — Posted on 2021-02-06

3314 Regulation of Dopamine D1 Receptor Signaling at the Golgi Apparatus by a Low Affinity Dopamine Transporter

Puri, N. M.; Romano, G. R.; Mai, Q. N.; Irannejad, R.

10.1101/2020.11.23.394445 — cell biology — Posted on 2021-02-06

3315 celldeath: a tool for detection of cell death in transmitted light microscopy images by deep learning-based visual recognition

La Greca, A.; Perez, N.; Milone, P. M.; Castaneda, S.; Scarafia, M. A.; Möbbs, A. M.; Waisman, A.; Moro, L. N.; Sevlever, G.; Luzzani, C.; Miriuka, S. G.

10.1101/2020.03.22.002253 — cell biology — Posted on 2021-02-06

3316 Discovery of fungal-specific targets and inhibitors using chemical phenotyping of pathogenic spore germination

Ortiz, S. C.; Huang, M.; Hull, C. M.

10.1101/2021.02.06.430071 — microbiology — Posted on 2021-02-06

3317 Cold adapted desiccation-tolerant bacteria isolated from polar soils presenting high resistance to anhydrobiosis

Nobrega, F.; Duarte, R. T. D.; Torres-Ballesteros, A. M.; Queiroz, L. L.; Whyte, L. G.; Pellizari, V. H.

10.1101/2021.02.06.430066 — microbiology — Posted on 2021-02-06

3318 Functional Annotation of Human Cognitive States using Deep Graph Convolution

Zhang, Y.; Tetrel, L.; Thirion, B.; Bellec, P.

10.1101/2020.04.24.060657 — neuroscience — Posted on 2021-02-06

3319 An optimal growth law for RNA composition and its partial implementation through ribosomal and tRNA gene locations in bacterial genomes

Hu, X.-P.; Lercher, M. J.

10.1101/2021.02.05.429890 — systems biology — Posted on 2021-02-06

3320 Target2DeNovoDrugPropMax : a novel programmatic tool incorporating deep learning and in silico methods for automated de novo drug design for any target of interest

Madaj, R.; Geoffrey A S, B.; Valluri, P. P.; Sanker, A.

10.1101/2020.12.11.421768 — bioinformatics — Posted on 2021-02-06

3321 Mechanically Transduced Immunosorbent Assay To Measure Protein-Protein Interactions

Petell, C. J.; Randene, K.; Pappas, M.; Sandoval, D.; Strahl, B.; Harrison, J. S.; Steimel, J. P.

10.1101/2021.02.05.429999 — biochemistry — Posted on 2021-02-06

3322 NeuroSCORE: A Genome-wide Omics-Based Model to Identify Candidate Disease Genes of the Central Nervous System

Davis, K. W.; Bilancia, C. G.; Martin, M.; Vanzo, R.; Rimmasch, M.; Hom, Y.; Uddin, M.; Serrano, M.

10.1101/2021.02.04.429640 — genomics — Posted on 2021-02-06

3323 Consistent ultra-long DNA sequencing with automated slow pipetting

Prall, T. M.; Neumann, E. K.; Karl, J. A.; Shortreed, C. G.; Baker, D. A.; Bussan, H. E.; Wiseman, R. W.; O'Connor, D. H.

10.1101/2020.09.18.302471 — genomics — Posted on 2021-02-06

3324 Cancer relevance of human genes

Qing, T.; Mohsen, H.; Cannataro, V. L.; Marczyk, M.; Rozenblit, M.; Foldi, J.; Murray, M. F.; Townsend, J. P.; Kluger, Y.; Gerstein, M.; Pusztai, L.

10.1101/2021.02.04.429823 — genomics — Posted on 2021-02-06

3325 ZCCHC8 is required for the degradation of pervasive transcripts originating from multiple genomic regulatory features

Collins, J. W.; Martin, D.; Genomics and Computational Biology Core, ; Wang, S.; Yamada, K. M.

10.1101/2021.01.29.428898 — genomics — Posted on 2021-02-06

3326 Interpreting machine learning models to investigate circadian regulation and facilitate exploration of clock function

Gardiner, L.-J.; Rusholme-Pilcher, R.; Colmer, J.; Rees, H.; Crescente, J. M.; Carrieri, A. P.; Duncan, S.; Pyzer-Knapp, E. O.; Krishna, R.; Halll, A.

10.1101/2021.02.04.429826 — genomics — Posted on 2021-02-06

3327 TRNP1 sequence, function and regulation co-evolve with cortical folding in mammals

Kliesmete, Z.; Wange, L. E.; Vieth, B.; Esgleas, M.; Radmer, J.; Huelsmann, M.; Geuder, J.; Richter, D.; Ohnuki, M.; Goetz, M.; Hellmann, I.; Enard, W.

10.1101/2021.02.05.429919 — evolutionary biology — Posted on 2021-02-06

3328 Capacity of countries to reduce biological invasions

Latombe, G.; Seebens, H.; Lenzner, B.; Courchamp, F.; Dullinger, S.; Golivets, M.; Kühn, I.; Leung, B.; Roura-Pascual, N.; Cebrian, E.; Dawson, W.; Diagne, C.; Jeschke, J. M.; Perez-Granados, C.; Liu, C.; Moser, D.; Turbelin, A.; Visconti, P.; Essl, F.

10.1101/2021.02.04.429788 — ecology — Posted on 2021-02-06

3329 Coupled Dynamics of Behavior and Disease Contagion Among Antagonistic Groups

Smaldino, P. E.; Jones, J. H.

10.1101/2020.06.17.157511 — ecology — Posted on 2021-02-06

3330 Hepatocyte nuclear factor 4a and glucocorticoid receptor coordinately regulate lipid metabolism in mice fed a high-fat-high-sugar diet

Lu, H.; Lei, X.; Winkler, R.; Guo, S.; John, S.; Kumar, D.; Li, W.; Alnouti, Y.

10.1101/2021.02.06.427306 — molecular biology — Posted on 2021-02-06

3331 Cotranslational folding of a periplasmic protein domain in Escherichia coli

Sandhu, H.; Hedman, R.; Cymer, F.; Kudva, R.; Ismail, N.; Von Heijne, G.

10.1101/2021.02.06.430026 — molecular biology — Posted on 2021-02-06

3332 Tn7-CRISPR-Cas12K elements manage pathway choice using truncated repeat-spacer units to target tRNA attachment sites

Hsieh, S.-C.; Peters, J. E.

10.1101/2021.02.06.429022 — molecular biology — Posted on 2021-02-06

3333 Osteomacs support osteoclast-mediated resorption and contribute to bone pathology in a postmenopausal osteoporosis mouse model

Batoon, L.; Millard, S. M.; Raggatt, L. J.; Wu, A. C.; Kaur, S.; Sun, L. W. H.; Williams, K.; Sandrock, C.; Ng, P. Y.; Bartnikowski, M.; Glatt, V.; Pavlos, N.; Pettit, A.

10.1101/2021.02.05.429872 — immunology — Posted on 2021-02-06

3334 Genome editing human primary T cells with microfluidic vortex shedding & CRISPR Cas9

Jarrell, J. A.; Sytsma, B. J.; Wilson, L. H.; Pan, F. L.; Lau, K. H. W. J.; Kirby, G. T. S.; Lievano, A. A.; Pawell, R. S.

10.1101/2020.02.26.960336 — immunology — Posted on 2021-02-06

3335 Sex and metabolic state interact to influence expression of passive avoidance memory in rats: Potential contribution of A2 noradrenergic neurons

Edwards, C. M.; Dolezel, T.; Rinaman, L.

10.1101/2021.02.04.429639 — neuroscience — Posted on 2021-02-06

3336 A Mathematical Model which Examines Age-Related Stochastic Fluctuations in DNA Maintenance Methylation

Zagkos, L.; Roberts, J.; Mc Auley, M.

10.1101/2021.02.05.429896 — systems biology — Posted on 2021-02-06

3337 Larval nutrition impacts survival to adulthood, body size, and the allometric scaling of metabolic rate in adult honeybees

Nicholls, E.; Rossi, M.; Niven, J. E.

10.1101/2021.02.05.429975 — physiology — Posted on 2021-02-06

3338 Thunor: Visualization and Analysis of High-Throughput Dose-response Datasets

Lubbock, A. L. R.; Harris, L. A.; Quaranta, V.; Tyson, D. R.; Lopez, C. F.

10.1101/530329 — pharmacology and toxicology — Posted on 2021-02-06

3339 Loss of HMCES is synthetic lethal with APOBEC activity in cancer cells

Biayna, J.; Garcia-Cao, I.; Alvarez, M. M.; Salvadores, M.; Espinosa-Carrasco, J.; McCullough, M.; Supek, F.; Stracker, T. H.

10.1101/2021.02.05.429803 — cancer biology — Posted on 2021-02-06

3340 Long-term antitumor CD8+ T cell immunity induced by endogenously engineered extracellular vesicles

Ferrantelli, F.; Manfredi, F.; Chiozzini, C.; Olivetta, E.; Giovannelli, A.; Leone, P.; Federico, M.

10.1101/2021.02.05.429897 — cancer biology — Posted on 2021-02-06

3341 Heterogeneous nuclear ribonucleoprotein K is overexpressed in acute myeloid leukemia and causes myeloproliferative disease in mice via altered Runx1 splicing

Aitken, M. J. L.; Malaney, P.; Zhang, X.; Herbrich, S. M.; Chan, L. E.; Ma, H.; Jacamo, R.; Duan, R.; Link, T. M.; Kornblau, S. M.; Kanagal-Shamanna, R.; Bueso-Ramos, C. E.; Post, S. M.

10.1101/2021.02.05.429385 — cancer biology — Posted on 2021-02-06

3342 FGFR2 fusion protein-driven mouse models of intrahepatic cholangiocarcinoma unveil a necessary role for Erk signaling

Cristinziano, G.; Porru, M.; Lamberti, D.; Buglioni, S.; Rollo, F.; Amoreo, C. A.; Manni, I.; Giannarelli, D.; Cristofoletti, C.; Russo, G.; Borad, M. J.; Grazi, G. L.; Diodoro, M. G.; Giordano, S.; Forcato, M.; Anastasi, S.; Leonetti, C.; Segatto, O.

10.1101/2020.05.20.106104 — cancer biology — Posted on 2021-02-06

3343 Improving RNA branching predictions: advances and limitations

Poznanovic, S.; Wood, C.; Cloer, M.; Heitsch, C.

10.1101/2021.02.04.429782 — bioinformatics — Posted on 2021-02-06

3344 The Case for Retaining Natural Language Descriptions of Phenotypes in Plant Databases and a Web Application as Proof of Concept

Braun, I. R.; Bassham, D. C.; Lawrence-Dill, C. J.

10.1101/2021.02.04.429796 — bioinformatics — Posted on 2021-02-06

3345 FINDER: An automated software package to annotate eukaryotic genes from RNA-Seq data and associated protein sequences

Banerjee, S.; Bhandary, P.; Woodhouse, M. R.; Sen, T. Z.; Wise, R. P.; Andorf, C. M.

10.1101/2021.02.04.429837 — bioinformatics — Posted on 2021-02-06

3346 CD8+ T cell immunogenicity induced by endogenous EVs engineered by antigens fused to a truncated Nefmut EV-anchoring protein

Chiozzini, C.; Manfredi, F.; Ferrantelli, F.; Leone, P.; giovannelli, a.; Olivetta, E.; Federico, M.

10.1101/2021.02.05.429891 — bioengineering — Posted on 2021-02-06

3347 Drosophila Evolution over Space and Time (DEST) - A New Population Genomics Resource

Kapun, M.; Nunez, J. C. B.; Bogaerts-Marquez, M.; Murga-Moreno, J.; Paris, M.; Outten, J.; Coronado-Zamora, M.; Tern, C.; Rota-Stabelli, O.; Garcia Guerreiro, M. P. P.; Casillas, S.; Orengo, D. J.; Puerma, E.; Kankare, M.; Ometto, L.; Loeschcke, V. V.; Onder, B. S.; Abbott, J. K.; Schaeffer, S. W.; Rajpurohit, S.; Behrman, E. L.; Schou, M. F.; Merritt, T. J. S.; Lazzaro, B. P. B.; Glaser-Schmitt, A.; Argyridou, E.; Staubach, F.; Wang, Y.; Tauber, E.; Serga, S. V.; Fabian, D. K.; Dyer, K. A.; Wheat, C. W.; Parsch, J.; Grath, S.; Savic Veselinovic, M.; Stamenkovic-Radak, M.; Jelic, M.; Buendia-R

10.1101/2021.02.01.428994 — genomics — Posted on 2021-02-06

3348 Suppression of miR-199a-5p alleviates ulcerative colitis by upregulating endoplasmic reticulum stress component XBP1

Wang, S.; Shen, L.; Peng, S.; Tian, M.; Li, X.; Luo, H.

10.1101/2021.02.05.430002 — genomics — Posted on 2021-02-06

3349 Analysis of mitochondrial genome methylation using Nanopore single-molecule sequencing

Lueth, T.; Klein, C.; Schaake, S.; Tse, R.; Pereira, S.; Lass, J.; Sinkkonen, L.; Gruenewald, A.; Trinh, J.

10.1101/2021.02.05.429923 — genetics — Posted on 2021-02-06

3350 Alternative splice variants and germline polymorphisms in human immunoglobulin light chain genes

Mikocziova, I.; Peres, A.; Gidoni, M.; Greiff, V.; Yaari, G.; Sollid, L. M.

10.1101/2021.02.05.429934 — genetics — Posted on 2021-02-06

3351 Enhanced genetic analysis of type 1 diabetes by selecting variants on both effect size and significance, and by integration with autoimmune thyroid disease

Crouch, D. J. M.; Inshaw, J. R. J.; Robertson, C. C.; Zhang, J.-Y.; Chen, W.-M.; Onengut-Gumuscu, S.; Cutler, A. J.; Sidore, C.; Cucca, F.; Pociot, F.; Concannon, P.; Rich, S. S.; Todd, J. A.

10.1101/2021.02.05.429962 — genetics — Posted on 2021-02-06

3352 Strong transgenerational effects but no genetic adaptation in zooplankton 24 years after an abrupt +10°C climate change

Pais-Costa, A. J.; Lievens, E. J. P.; Redon, S.; Sanchez, M. I.; Jabbour-Zahab, R.; Joncour, P.; Van Hoa, N.; Van Stappen, G.; Lenormand, T.

10.1101/2021.02.05.429921 — evolutionary biology — Posted on 2021-02-06

3353 The Goldilocks Effect: Female geladas in mid-sized groups have higher fitness

Tinsley Johnson, E.; Feder, J.; Bergman, T. J.; Lu, A.; Snyder-Mackler, N.; Beehner, J. C.

10.1101/348383 — evolutionary biology — Posted on 2021-02-06

3354 Contingency and chance erase necessity in the experimental evolution of ancestral proteins

Xie, V. C.; Pu, J.; Metzger, B. P. H.; Thornton, J. W.; Dickinson, B.

10.1101/2020.08.29.273581 — evolutionary biology — Posted on 2021-02-06

3355 Potential of Synthetic Aperture Radar Sentinel-1 time series for the monitoring of phenological cycles in a deciduous forest

SOUDANI, K.; Delpierre, N.; Berveiller, D.; Hmimina, G.; Vincent, G.; Morfin, A.; Dufrene, E.

10.1101/2021.02.04.429811 — ecology — Posted on 2021-02-06

3356 Characterization of a novel Fgf10CreERT2 knock-in mouse line targeting postnatal lung Fgf10 lineages

Chu, X.; Taghizadeh, S.; Vasquez-Armendariz, A. I.; Herold, S.; Lei, C.; Zhang, J. S.; El Agha, E.; Bellusci, S.

10.1101/2021.02.05.429562 — developmental biology — Posted on 2021-02-06

3357 Quantitative assessment of constitutive G protein-coupled receptor activity with BRET-based G protein biosensors

Schihada, H.; Shekhani, R.; Schulte, G.

10.1101/2021.02.05.429900 — cell biology — Posted on 2021-02-06

3358 The lysosomal chloride-proton exchanger CLC7 functions in melanosomes as a negative regulator of human pigmentation

Koroma, D. C.; Scales, J. L.; Trotman, J. C.; Wakamatsu, K.; Ito, S.; Oancea, E.

10.1101/2021.02.05.430016 — cell biology — Posted on 2021-02-06

3359 Coordinate transcriptional and post-transcriptional repression of pro-differentiation genes maintains intestinal stem cell identity

Buddika, K.; Huang, Y.-T.; Ariyapala, I. S.; Butrum-Griffith, A.; Norrell, S. A.; OConnor, A. M.; Patel, V. K.; Rector, S. A.; Slovan, M.; Sokolowski, M.; Kato, Y.; Nakamura, A.; Sokol, N. S.

10.1101/2020.06.27.175398 — cell biology — Posted on 2021-02-06

3360 Repurposing of Synaptonemal Complex Proteins for Kinetochores in Kinetoplastida

Tromer, E. C.; Wemyss, T. A.; Waller, R. F.; Akiyoshi, B.

10.1101/2021.02.06.430040 — cell biology — Posted on 2021-02-06

3361 The nucleoid-associated protein Gbn binds to GATC sequences and affects sporulation and antibiotic production in Streptomyces

Du, C.; Willemse, J.; Carrion, V. J.; Erkelens, A. M.; van Wezel, G. P.; Dame, R. T.

10.1101/2021.02.06.430045 — molecular biology — Posted on 2021-02-06

3362 G9a/GLP methyltransferases inhibit autophagy by methylation-mediated ATG12 protein degradation

Kim, C.-H.; Lee, S.-H.; Park, K.-T.

10.1101/2021.02.05.430008 — molecular biology — Posted on 2021-02-06

3363 The cryo-EM structure of vesivirus 2117 highlights functional variations in entry pathways for viruses in different clades of the vesivirus genus.

Sutherland, H.; Conley, M. J.; Emmott, E.; Streetley, J.; Goodfellow, I. G.; Bhella, D.

10.1101/2021.02.05.429895 — microbiology — Posted on 2021-02-06

3364 Subgenomic RNAs as molecular indicators of asymptomatic SARS-CoV-2 infection

Wong, C. H.; Ngan, C. Y.; Goldfeder, R. L.; Idol, J.; Kuhlberg, C.; Maurya, R.; Kelly, K.; Omerza, G.; Renzette, N.; Abreu, F. D.; Li, L.; Browne, F. A.; Liu, E. T.; Wei, C.-L.

10.1101/2021.02.06.430041 — microbiology — Posted on 2021-02-06

3365 Systematic measurement of combination drug landscapes to predict in vivo treatment outcomes for tuberculosis

Larkins-Ford, J.; Greenstein, T.; Van, N.; Degefu, Y. N.; Olson, M. C.; Sokolov, A.; Aldridge, B. B.

10.1101/2021.02.03.429579 — microbiology — Posted on 2021-02-06

3366 IL-1-driven stromal-neutrophil interaction in deep ulcers defines a pathotype of therapy non-responsive inflammatory bowel disease

Friedrich, M.; Pohin, M.; Jackson, M. A.; Korsunsky, I.; Bullers, S.; Rue-Albrecht, K.; Christoforidou, Z.; Santhananthan, D.; Ravindran, R.; Sanches Peres, R.; Sharpe, H.; Wei, K.; Watts, G. F. M.; Mann, E. H.; Geremia, A.; Thomas, T.; Attar, M.; Oxford IBD Cohort Investigators, ; Roche Fibroblast Network Consortium, ; McCuaig, S.; Thomas, L.; Collantes, E.; Uhlig, H. H.; Sansom, S. N.; Easton, A.; Raychaudhuri, S.; Travis, S. P.; Powrie, F. M.

10.1101/2021.02.05.429804 — immunology — Posted on 2021-02-06

3367 Fear in the mind's eye: Mental imagery can generate and regulate acquired differential fear conditioned reactivity

Greening, S. G.; Lee, T.-H.; Gregoire, L.; Burleigh, L.; Robinson, T.; Jiang, X.; Mather, M.; Kaplan, J.

10.1101/2021.02.04.429795 — neuroscience — Posted on 2021-02-06

3368 Expectation-Based Gist Facilitation: Rapid Scene Understanding and the Role of Top-Down Information

McLean, D.; Renoult, L.; Malcolm, G. L.

10.1101/2021.02.04.429791 — neuroscience — Posted on 2021-02-06

3369 A comparison of population receptive fields from fMRI and large-scale neurophysiological recordings in non-human primates.

Klink, P. C.; Chen, X.; Vanduffel, W.; Roelfsema, P.

10.1101/2020.09.05.284133 — neuroscience — Posted on 2021-02-06

3370 A novel RyR1 inhibitor prevents and rescues sudden death in a mouse model of malignant hyperthermia and heat stroke

Yamazawa, T.; Kobayashi, T.; Kurebayashi, N.; Konishi, M.; Noguchi, S.; Inoue, T.; Inoue, Y. U.; Nishino, I.; Mori, S.; Iinuma, H.; Manaka, N.; Kagechika, H.; Uryas, A.; Adams, J.; Lopez, J. R.; Liu, X.; Diggle, C.; Allen, P. D.; Kakizawa, S.; Ikeda, K.; Lin, B.; Ikemi, Y.; Nunomura, K.; Nakagawa, S.; Sakurai, T.; Murayama, T.

10.1101/2020.07.02.185520 — pharmacology and toxicology — Posted on 2021-02-06

3371 Activity pulses induce spontaneous flow reversals in viscoelastic environments

Plan, E. L. C. V. M.; Yeomans, J. M.; Doostmohammadi, A.

10.1101/2021.02.05.429955 — biophysics — Posted on 2021-02-06

3372 Engineering Threshold-Based Selection Systems

Pedone, K. H.; Gonzalez-Perez, V.; Leopold, L. E.; Der, C. J.; Cox, A. D.; Ahmed, S.; Reiner, D. J.

10.1101/2021.02.04.429784 — genetics — Posted on 2021-02-06

3373 Genetic Analysis of Right Heart Structure and Function in 40,000 People

Pirruccello, J. P.; Di Achille, P.; Nauffal, V.; Nekoui, M.; Friedman, S. N.; Klarqvist, M. D. R.; Chaffin, M. D.; Khurshid, S.; Roselli, C.; Batra, P.; Ng, K.; Lubitz, S. A.; Ho, J. E.; Lindsay, M. E.; Philippakis, A. A.; Ellinor, P. T.

10.1101/2021.02.05.429046 — genetics — Posted on 2021-02-06

3374 Real-time conversion of tissue-scale mechanical forces into an interdigitated growth pattern

Belteton, S. A.; Li, W.; Yanagisawa, M.; Afshar-Hatam, F.; Quinn, M. I.; Szymanski, M. K.; Marley, M. W.; Turner, J. A.; Szymanski, D. B.

10.1101/2021.02.06.428645 — cell biology — Posted on 2021-02-06

3375 The differentiation of pluripotent stem cells towards transplantable endothelial progenitor cells

YANG, J.; Qin, k.

10.1101/2021.02.05.430011 — cell biology — Posted on 2021-02-06

3376 The glycosphingolipid inhibitor eliglustat inhibits autophagy in osteoclasts to increase bone mass and reduce myeloma bone disease

Leng, H.; Zhang, H.; Li, L.; Zhang, S.; Wang, Y.; Ersek, A.; Morris, E.; Sezgin, E.; Lee, Y.-H.; Li, Y.; Mi, J.; Zhong, Q.; Edwards, C.; Simon, A. K.; Horwood, N. J.

10.1101/2021.02.05.429906 — cell biology — Posted on 2021-02-06

3377 A novel class of sulfur-containing aminolipids widespread in marine roseobacters

Smith, A.; Silvano, E.; Pauker, O.; Guillonneau, R.; Quareshy, M.; Murphy, A.; Mausz, M. A.; Stirrup, R.; Rihtman, B.; Ferretjans, M. A.; Brandsma, J.; Petersen, J.; Scanlan, D. J.; Chen, Y.

10.1101/2021.02.05.429882 — microbiology — Posted on 2021-02-06

3378 Active microrheology using pulsed optical tweezers to probe viscoelasticity of Lamin A towards diagnosis of laminopathies

Mukherjee, C.; Kundu, A.; Dey, R.; Banerjee, A.; Sengupta, K.

10.1101/2021.02.05.429901 — biophysics — Posted on 2021-02-06

3379 In vivo magnetic resonance spectroscopy of hyperpolarized pyruvate in a male guinea pig model of life-long Western diet consumption and non-alcoholic fatty liver disease development

Smith, L. M.; Pitts, C. B.; Friesen-Waldner, L. J.; Prabhu, N. H.; Mathers, K. E.; Sinclair, K. J.; Wade, T. P.; Regnault, T. R.; McKenzie, C. A.

10.1101/2021.02.05.429612 — biophysics — Posted on 2021-02-06

3380 waveRAPID(R) - a robust assay for high-throughput kinetic screens with the Creoptix(R) WAVEsystem

Kartal, O.; Andres, F.; Lai, M. P.; Nehme, R.; Cottier, K.

10.1101/2021.02.05.429874 — biophysics — Posted on 2021-02-06

3381 LAMP3 is critical for surfactant homeostasis in mice

Lunding, L. P.; Krause, D.; Stichtenoth, G.; Stamme, C.; Lauterbach, N.; Hegermann, J.; Ochs, M.; Schuster, B.; Sedlacek, R.; Saftig, P.; Schwudke, D.; Wegmann, M.; Damme, M.

10.1101/2021.02.05.429758 — biochemistry — Posted on 2021-02-06

3382 A Mendelian randomization study of the role of lipoprotein subfractions in coronary artery disease

Zhao, Q.; Wang, J.; Miao, Z.; Zhang, N. R.; Hennessy, S.; Small, D. S.; Rader, D. J.

10.1101/691089 — genetics — Posted on 2021-02-06

3383 Macroscopic quantities of collective brain activity during wakefulness and anesthesia

Ponce-Alvarez, A.; Uhrig, L.; Deco, N.; Signorelli, C. M.; Kringelbach, M.; Jarraya, B.; Deco, G.

10.1101/2021.02.03.429578 — neuroscience — Posted on 2021-02-06

3384 Effects of LSD are differentially modulated in arrestin knockout mice

Rodriguiz, R. M.; Nadkarni, V.; Means, C. R.; Chiu, Y.-T.; Roth, B. L.; Wetsel, W. C.

10.1101/2021.02.04.429772 — neuroscience — Posted on 2021-02-06

3385 Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors

Thibado, J.; Tano, J.-Y.; Lee, J.; Salas-Estrada, L.; Provasi, D.; Strauss, A.; Marcelo Lamim Ribeiro, J.; Xiang, G.; Broichhagen, J.; Filizola, M.; Lohse, M.; Levitz, J.

10.1101/2021.02.04.429701 — neuroscience — Posted on 2021-02-06

3386 Cancer cells adapt FAM134B-BiP complex mediated ER-phagy to survive hypoxic stress

Chipurupalli, S.; Ganesan, R.; Martini, G.; Mele, L.; Kannan, E.; Namasivayam, V.; Desiderio, V.; Robinson, N.

10.1101/2021.02.05.429931 — cancer biology — Posted on 2021-02-06

3387 The Integrity of the Speciation Core Complex is necessary for centromeric binding and reproductive isolation in Drosophila

Lukacs, A.; Thomae, A. W.; Krueger, P.; Schauer, T.; Venkateswaran Venkatasubramani, A.; Kochanova, N. Y.; Aftab, W.; Choudhury, R.; Forne, I.; Imhof, A.

10.1101/2021.02.05.429932 — biochemistry — Posted on 2021-02-06

3388 Rampant tooth loss across 200 million years of frog evolution

Paluh, D. J.; Riddell, K.; Early, C. M.; Hantak, M. M.; Jongsma, G. F.; Keeffe, R. M.; Magalhaes Silva, F.; Nielsen, S. V.; Vallejo-Pareja, M. C.; Stanley, E. L.; Blackburn, D. C.

10.1101/2021.02.04.429809 — evolutionary biology — Posted on 2021-02-06

3389 Mosquito community composition shapes virus prevalence patterns along anthropogenic disturbance gradients

Hermanns, K.; Marklewitz, M.; Zirkel, F.; Kopp, A.; Kramer-Schadt, S.; Junglen, S.

10.1101/2021.02.04.429754 — ecology — Posted on 2021-02-06

3390 SSNA1 stabilizes dynamic microtubules and detects microtubule damage

Lawrence, B.; Arnaiz, C.; Arpag, G.; Zanic, M.

10.1101/2021.02.05.429994 — biophysics — Posted on 2021-02-06

3391 Insights into the mechanisms of LOV domain color tuning from a set of high-resolution X-ray structures

Remeeva, A.; Nazarenko, V. V.; Kovalev, K.; Goncharov, I. M.; Yudenko, A.; Astashkin, R.; Gordeliy, V.; Gushchin, I.

10.1101/2021.02.05.429969 — biophysics — Posted on 2021-02-06

3392 Mechanically Transduced Immunosorbent Assay To Measure Protein-Protein Interactions

Petell, C. J.; Randene, K.; Pappas, M.; Sandoval, D.; Strahl, B.; Harrison, J. S.; Steimel, J. P.

10.1101/2021.02.05.429999 — biochemistry — Posted on 2021-02-06

3393 Snowball Earths, population bottlenecks, and the evolution of marine photosynthetic bacteria

ZHANG, H.; SUN, Y.; Zeng, Q.; Crowe, S. A.; Luo, H.

10.1101/2020.11.24.395392 — microbiology — Posted on 2021-02-06

3394 Sublingual allergen immunotherapy with recombinant dog allergens prevents airway hyperresponsiveness in a model of asthma marked by vigorous TH2 and TH17 cell responses

Stark, J. M.; Liu, J.; Tibbitt, C. A.; Christian, M.; Ma, J.; Wintersand, A.; Murrell, B.; Adner, M.; Gronlund, H.; Gafvelin, G.; Coquet, J. M.

10.1101/2021.02.04.429730 — immunology — Posted on 2021-02-06

3395 Modeling mutational effects on biochemical phenotypes using convolutional neural networks: application to SARS-CoV-2

Wang, B.; Gamazon, E. R.

10.1101/2021.01.28.428521 — bioinformatics — Posted on 2021-02-06

3396 Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells.

Borriello, L.; Coste, A.; Sharma, V.; Karagiannis, G.; Lin, Y.; Wang, Y.; Ye, X.; Duran, C.; Chen, X.; Dalla, E.; Singh, D.; Oktay, M.; Condeelis, J.; Entenberg, D.

10.1101/2021.02.04.429798 — cancer biology — Posted on 2021-02-05

3397 Cryo-EM Structure of Bacterioferritin Nanocages Provides Insight into the Bio-mineralization of Ferritins

Jobichen, C.; Ying Chong, T.; Rattinam, R.; Basak, S.; Srinivasan, M.; Pandey, K. P.; Ngoc, T. B.; Jian, S.; Angayarkanni, J.; Sivaraman, J.

10.1101/2021.02.04.429857 — biophysics — Posted on 2021-02-05

3398 Dynamics of vesicle reshaping and scission under osmotic shocks

Vanhille-Campos, C.; Saric, A.

10.1101/2020.11.16.384602 — biophysics — Posted on 2021-02-05

3399 Digital twinning of Cellular Capsule Technology: emerging outcomes from the perspective of porous media mechanics

Urcun, S.; Rohan, P.-Y.; Skalli, W.; Nassoy, P.; Bordas, S. P. A.; Sciume, G.

10.1101/2020.06.09.142927 — biophysics — Posted on 2021-02-05

3400 Understanding population history of range expansion and environmental adaptation by visualizing gene-environment-trait associations

Nakamichi, R.; Kitada, S.; Kishino, H.

10.1101/452581 — bioinformatics — Posted on 2021-02-05

3401 BiSulfite Bolt: A BiSulfite Sequencing Analysis Platform

Farrell, C.; Thompson, M.; Tosevska, A.; Oyetunde, A.; Pellegrini, M.

10.1101/2020.10.06.328559 — bioinformatics — Posted on 2021-02-05

3402 Exploring protein sequence and functional spaces using adversarial autoencoder

Bitard-Feildel, T.

10.1101/2020.11.09.375311 — bioinformatics — Posted on 2021-02-05

3403 Towards a Better Understanding of Reverse-Complement Equivariance for Deep Learning Models in Regulatory Genomics

Zhou, H.; Shrikumar, A.; Kundaje, A.

10.1101/2020.11.04.368803 — bioinformatics — Posted on 2021-02-05

3404 FAIRSCAPE: A Framework for FAIR and Reproducible Biomedical Analytics

Levinson, M. A.; Niestroy, J.; Al Manir, S.; Fairchild, K. D.; Lake, D. E.; Moorman, J. R.; Clark, T.

10.1101/2020.08.10.244947 — bioinformatics — Posted on 2021-02-05

3405 Automatic Landmark Detection of Human Back Surface from Depth Images via Deep Learning

Delgarmi, M.; Heravi, H.; Rahimpour Jounghani, A.; Shahrezie, A.; Ebrahimi, A.; Shamsi, M.

10.1101/2021.02.04.429842 — bioengineering — Posted on 2021-02-05

3406 Automatic Identification and Avoidance of Axon Bundle Activation for Epiretinal Prosthesis

Tandon, P.; Bhaskar, N.; Shah, N.; Madugula, S.; Grosberg, L. E.; Fan, V. H.; Hottowy, P.; Sher, A.; Litke, A. M.; Chichilnisky, E. J.; Mitra, S.

10.1101/2021.02.03.429317 — bioengineering — Posted on 2021-02-05

3407 Analytical Performance of a Standardized Kit for Mass Spectrometry-based Measurements of Human Glycosaminoglycans

Tamburro, D.; Bratulic, S.; Shameh, S. A.; Soni, N. K.; Bacconi, A.; Maccari, F.; Galeotti, F.; Mattsson, K.; Volpi, N.; Nielsen, J.; Gatto, F.

10.1101/2021.02.04.429694 — biochemistry — Posted on 2021-02-05

3408 13C tracer analysis identifies extensive recycling of endogenous CO2 in vivo

Duan, L.; Cooper, D. E.; Scheidemantle, G.; Locasale, J.; Kirsch, D. G.; Liu, X.

10.1101/2021.02.04.429777 — biochemistry — Posted on 2021-02-05

3409 Alternative architecture of the E. coli chemosensory array

Burt, A.; Cassidy, C. K.; Stansfeld, P. J.; Gutsche, I.

10.1101/2021.02.05.429929 — biochemistry — Posted on 2021-02-05

3410 Splicing motifs are organized within global structural scaffold of a pre-mRNA

Saha, K.; Fernandez, M. M.; Biswas, T.; Joseph, S.; Ghosh, G.

10.1101/292458 — biochemistry — Posted on 2021-02-05

3411 Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

Tian, R.; Abarientos, A.; Hong, J.; Hashemi, S. H.; Yan, R.; Draeger, N.; Leng, K.; Nalls, M. A.; Singleton, A. B.; Xu, K.; Faghri, F.; Kampmann, M.

10.1101/2020.06.27.175679 — genomics — Posted on 2021-02-05

3412 Insights into Mus musculus subspecies population structure across Eurasia revealed by whole-genome sequence analysis

Fujiwara, K.; Kawai, Y.; Moriwaki, K.; Takada, T.; Shiroishi, T.; Saitou, N.; Suzuki, H.; Osada, N.

10.1101/2021.02.05.429881 — genomics — Posted on 2021-02-05

3413 Identification of LINE retrotransposons and long non-coding RNAs expressed in the octopus brain

Petrosino, G.; Ponte, G.; Volpe, M.; Zarrella, I.; Langella, C.; Di Cristina, G.; Finaurini, S.; Russo, M. T.; Basu, S.; Musacchia, F.; Ristoratore, F.; Pavlinic, D.; Benes, V.; Ferrante, M. I.; Albertin, C.; Simakov, O.; Gustincich, S.; Fiorito, G.; Sanges, R.

10.1101/2021.01.24.427974 — genomics — Posted on 2021-02-05

3414 Identification of Novel Genetic Susceptibility Loci for Thoracic and Abdominal Aortic Aneurysms Via Genome-Wide Association Study Using the UK Biobank Cohort

Ashvetiya, T.; Fan, S. X.; Chen, Y.-J.; Williams, C. H.; O'Connell, J. R.; Perry, J. A.; Hong, C. C.

10.1101/2021.02.05.429911 — genomics — Posted on 2021-02-05

3415 Bayesian modeling of skewed X inactivation ingenetically diverse mice identifies a novel Xce allele associated with copy number changes

Sun, K. Y.; Oreper, D. G.; Schoenrock, S. A.; McMullan, R.; Giusti-Rodriguez, P.; Zhabotynsky, V.; Miller, D. R.; Tarantino, L. M.; Pardo-Manuel de Villena, F.; Valdar, W.

10.1101/2020.11.13.380535 — genetics — Posted on 2021-02-05

3416 Chance, contingency, and necessity in the experimental evolution of ancestral proteins

Xie, V. C.; Pu, J.; Metzger, B. P. H.; Thornton, J. W.; Dickinson, B.

10.1101/2020.08.29.273581 — evolutionary biology — Posted on 2021-02-05

3417 Alteration of gut microbiota with rifampicin does not impair maternal care in the European earwig

Van Meyel, S.; Devers, S.; Dupont, S.; Dedeine, F.; Meunier, J.

10.1101/2020.10.08.331363 — evolutionary biology — Posted on 2021-02-05

3418 Polygenic adaptation, clonal interference, and the evolution of mutators in experimental Pseudomonas aeruginosa populations

Harris, K. B.; Flynn, K. M.; Cooper, V. S.

10.1101/2021.01.14.426720 — evolutionary biology — Posted on 2021-02-05

3419 Ancient genomes reveal hybridisation between extinct short-faced bears and the extant spectacled bear (Tremarctos ornatus)

Salis, A. T.; Gower, G.; Schubert, B. W.; Soibelzon, L. H.; Heiniger, H.; Prieto, A.; Prevosti, F. J.; Meachen, J.; Cooper, A.; Mitchell, K. J.

10.1101/2021.02.05.429853 — evolutionary biology — Posted on 2021-02-05

3420 Male genital lobe morphology affects the chance to copulate in Drosophila pachea

Lefevre, B. M.; Catte, D.; Courtier-Orgogozo, V.; Lang, M.

10.1101/816538 — evolutionary biology — Posted on 2021-02-05

3421 TRNP1 sequence, function and regulation co-evolve with cortical folding in mammals

Enard, W.; Hellmann, I.; Goetz, M.; Esgleas, M.; Huelsmann, M.; Kliesmete, Z.; Wange, L. E.; Vieth, B.; Radmer, J.; Geuder, J.; Richter, D.; Ohnuki, M.

10.1101/2021.02.05.429919 — evolutionary biology — Posted on 2021-02-05

3422 Habitat selection by the Ringed Kingfisher (Megaceryle torquata stictipennis) in Basse-Terre, Guadeloupe: Possible negative association with chlordecone pollution

Villard, P.; Ferchal, A.; Feldmann, P.; Pavis, C.; Bonenfant, C.

10.1101/2020.04.15.038729 — ecology — Posted on 2021-02-05

3423 Evolution and connectivity influence the persistence and recovery of coral reefs under climate change in the Caribbean, Southwest Pacific, and Coral Triangle

McManus, L. C.; Forrest, D. L.; Tekwa, E. W.; Schindler, D. E.; Colton, M. A.; Webster, M. M.; Essington, T. E.; Palumbi, S. R.; Mumby, P. J.; Pinsky, M. L.

10.1101/2021.02.04.429453 — ecology — Posted on 2021-02-05

3424 Montane species track rising temperatures better in the tropics than in the temperate zone

Freeman, B.; Song, Y.; Feeley, K.; Zhu, K.

10.1101/2020.05.18.102848 — ecology — Posted on 2021-02-05

3425 The impacts of hydropower on freshwater macroinvertebrate richness: A global meta-analysis

Trottier, G.; Turgeon, K.; Boisclair, D.; Margni, M.; Bulle, C.

10.1101/2021.02.05.429909 — ecology — Posted on 2021-02-05

3426 Calcium-vesicles perform active diffusion in the sea urchin embryo during larval biomineralization

Winter, M.; Morgulis, M.; Gildor, T.; Cohen, A. R.; Ben-Tabou de-Leon, S.

10.1101/2020.08.14.244053 — developmental biology — Posted on 2021-02-05

3427 β-importins Tnpo-SR and Cadmus and the small GTPase Ran promote ovarian cyst formation in Drosophila

Beachum, A. N.; Hinnant, T. D.; Williams, A. E.; Powell, A. M.; Ables, E. T.

10.1101/2021.01.31.429051 — developmental biology — Posted on 2021-02-05

3428 Morphogenetic coupling leads to pattern emergence in the pre somitic mesoderm

Fulton, T.; Hwang, S.; Wang, Y.; Thomson, L.; Clark, B.; Verd, B.; Steventon, B.

10.1101/2021.02.05.429898 — developmental biology — Posted on 2021-02-05

3429 Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads

Belicova, L.; Repnik, U.; Delpierre, J.; Gralinska, E.; Seifert, S.; Valenzuela, J. I.; Morales-Navarrete, H. A.; Franke, C.; Raagel, H.; Shcherbinina, E.; Prikazchikova, T. P.; Koteliansky, V.; Vingron, M.; Kalaidzidis, Y.; Zatsepin, T.; Zerial, M.

10.1101/2020.12.31.424978 — cell biology — Posted on 2021-02-05

3430 Chromatin Bridges, not Micronuclei, Activate cGAS after Drug-induced Mitotic Errors in Human Cells

Flynn, P. J.; Koch, P. D.; Mitchison, T. J.

10.1101/2021.02.02.429360 — cell biology — Posted on 2021-02-05

3431 Structural and molecular basis for Cardiovirus 2A protein as a viral gene expression switch

Hill, C. H.; Napthine, S.; Pekarek, L.; Kibe, A.; Firth, A. E.; Graham, S. C.; Caliskan, N.; Brierley, I.

10.1101/2020.08.11.245035 — molecular biology — Posted on 2021-02-05

3432 Defining the role of the polyasparagine repeat domain of the S. cerevisiae transcription factor Azf1p

Stewart, T.; Wolfe, B. E.; Fuchs, S. M.

10.1101/2021.02.05.429910 — molecular biology — Posted on 2021-02-05

3433 Spatio-temporal control of DNA replication by the pneumococcal cell cycle regulator CcrZ

Gallay, C.; Sanselicio, S.; Anderson, M. E.; Soh, Y. M.; Liu, X.; Stamsas, G. A.; Pelliciari, S.; van Raaphorst, R.; Denereaz, J.; Kjos, M.; Murray, H.; Gruber, S.; Grossman, A. D.; Veening, J.-W.

10.1101/775536 — microbiology — Posted on 2021-02-05

3434 Phylogenetic and population structure analyses uncover pervasive misclassification and help assessing the biosafety of Pseudomonas putida for biotechnological applications

Araujo, H. P.; Jacobs, S. H.; Franco, G. R.; Venancio, T. M.

10.1101/2020.12.22.423983 — microbiology — Posted on 2021-02-05

3435 Spatial segregation and cooperation in radially expanding microbial colonies under antibiotic stress

Sharma, A.; Wood, K. B.

10.1101/2020.02.18.954644 — microbiology — Posted on 2021-02-05

3436 Systems-Level Proteomics Evaluation of Microglia Response to Tumor-Supportive Anti-inflammatory Cytokines

Ahuja, S.; Lazar, I. M.

10.1101/2021.02.04.429830 — immunology — Posted on 2021-02-05

3437 Sequence structure context organizes items in varied latent states of working memory neural network

Huang, Q.; Zhang, H.; Luo, H.

10.1101/2020.06.20.162438 — neuroscience — Posted on 2021-02-05

3438 Cognitive and GABAergic protection by hAPPSw,Ind and hTauVLW coexpression: a model of Non-Demented with Alzheimer's disease Neuropathology

Davila-Bouziguet, E.; Casoliba-Melich, A.; Targa-Fabra, G.; Galera-Lopez, L.; Ozaita, A.; Maldonado, R.; Delgado-Garcia, J. M.; Gruart, A.; Avila, J.; Soriano, E.; Pascual, M.

10.1101/2020.12.10.417907 — neuroscience — Posted on 2021-02-05

3439 Average beta burst duration profiles provide a signature of dynamical changes between the ON and OFF medication states in Parkinson's disease

Duchet, B.; Ghezzi, F.; Weerasinghe, G.; Tinkhauser, G.; Kuhn, A. A.; Brown, P.; Bick, C.; Bogacz, R.

10.1101/2020.04.27.064246 — neuroscience — Posted on 2021-02-05

3440 Predictive visual motion extrapolation emerges spontaneously and without supervision at each layer of a hierarchical neural network with spike-timing-dependent plasticity

Burkitt, A. N.; Hogendoorn, H.

10.1101/2020.08.01.232595 — neuroscience — Posted on 2021-02-05

3441 Sodium channel Nav1.2-L1342P variant displaying complex biophysical properties renders hyperexcitability of cortical neurons derived fromhuman iPSCs

Que, Z.; Olivero-Acosta, M. I.; Zhang, J.; Eaton, M.; Skarnes, W. C.; Yang, Y.

10.1101/2021.01.18.427192 — neuroscience — Posted on 2021-02-05

3442 Local projections of layer Vb-to-Va are more effective in lateral than in medial entorhinal cortex

Ohara, S.; Blankvoort, S.; Nair, R. R.; Nigro, M. J.; Nilssen, E. S.; Kentros, C.; Witter, M. P.

10.1101/2020.09.17.301002 — neuroscience — Posted on 2021-02-05

3443 Rhythmic coordination of hippocampal-prefrontal ensembles for odor-place associative memory and decision making

Symanski, C. A.; Bladon, J. H.; Kullberg, E. T.; Jadhav, S. P.

10.1101/2020.06.08.140939 — neuroscience — Posted on 2021-02-05

3444 Extended experience reveals distinct representational dynamics governing the CA1 spatial code

Keinath, A. T.; Mosser, C.-A.; Brandon, M. P.

10.1101/2021.01.12.426395 — neuroscience — Posted on 2021-02-05

3445 The temporal and spectral characteristics of expectations and prediction errors in pain and thermoception

Strube, A.; Rose, M.; Fazeli, S.; Büchel, C.

10.1101/2020.09.10.291658 — neuroscience — Posted on 2021-02-05

3446 Multiple dimensions underlying the functional organisation of the language network

Hodgson, V. J.; Lambon Ralph, M.; Jackson, R. L.

10.1101/2021.02.05.429902 — neuroscience — Posted on 2021-02-05

3447 A nested cortical hierarchy of neural states underlies event segmentation in the human brain

Geerligs, L.; van Gerven, M.; Campbell, K.; Güclü, U.

10.1101/2021.02.05.429165 — neuroscience — Posted on 2021-02-05

3448 Detecting neural state transitions underlying event segmentation

Geerligs, L.; van Gerven, M.; Güclü, U.

10.1101/2020.04.30.069989 — neuroscience — Posted on 2021-02-05

3449 What The Brain Does As We Speak

Forseth, K. J.; Pitkow, X.; Fischer-Baum, S.; Tandon, N.

10.1101/2021.02.05.429841 — neuroscience — Posted on 2021-02-05

3450 Neural Network Organization for Courtship Song Feature Detection in Drosophila

Baker, C. A.; McKellar, C.; Nern, A.; Dorkenwald, S.; Pacheco, D. A.; Pang, R.; Eckstein, N.; Funke, J.; Dickson, B. J.; Murthy, M.

10.1101/2020.10.08.332148 — neuroscience — Posted on 2021-02-05

3451 Quantifying the regulatory role of individual transcription factors in Escherichia coli

Guharajan, S.; Chhabra, S.; Parisutham, V.; Brewster, R. C.

10.1101/2021.01.04.425191 — systems biology — Posted on 2021-02-05

3452 Small in size, big on taste: metabolomics analysis of flavor compounds from Philippine garlic

Rellin, K. F.; Molino, R. J. E.; Junio, H.; Nellas, R. B.

10.1101/2021.02.05.429908 — systems biology — Posted on 2021-02-05

3453 A new approach to evaluate scientific production

Pfrieger, F. W.

10.1101/2020.06.01.128355 — scientific communication and education — Posted on 2021-02-05

3454 The Physcomitrium (Physcomitrella) patens PpKAI2L receptors for strigolactones and related compounds highlight MAX2 dependent and independent pathways

LOPEZ-OBANDO, M.; GUILLORY, A.; BOYER, F.-D.; CORNU, D.; HOFFMANN, B.; LE BRIS, P.; POUVREAU, J.-B.; DELAVAULT, P.; RAMEAU, C.; DE SAINT GERMAIN, A.; BONHOMME, S.

10.1101/2020.11.24.395954 — plant biology — Posted on 2021-02-05

3455 Cytoplasmic and nuclear Sw-5b NLR act both independently and synergistically to dictate full host defense against tospovirus infection

Chen, H.; Qian, X.; Chen, X.; Yang, T.; Feng, M.; Chen, J.; Cheng, R.; Hong, H.; Zheng, Y.; Mei, Y.; Shen, D.; Xu, Y.; Zhu, M.; Ding, X. S.; Tao, X.

10.1101/2020.12.24.424293 — plant biology — Posted on 2021-02-05

3456 The epoxyeicosatrienoic pathway is intact in endothelial and smooth muscle cells exposed to aldosterone excess

10.1101/2021.02.04.429624 — physiology — Posted on 2021-02-05

3457 Bayesian modeling and simulation to inform rare disease drug development early decision-making: application to Duchenne muscular dystrophy

Lennie, J.; Mondick, J. T.; Gastonguay, M. R.

10.1101/2021.02.05.429907 — pharmacology and toxicology — Posted on 2021-02-05

3458 Individual tree-crown detection in RGB imagery using semi-supervised deep learning neural networks

Weinstein, B.; Marconi, S.; Bohlman, S.; Zare, A.; White, E.

10.1101/532952 — ecology — Posted on 2021-02-05

3459 Mathematical model reveals that heterogeneity in the number of ion transporters regulates the fraction of mouse sperm capacitation

Aguado-Garcia, A.; Priego Espinosa, D. A.; Aldana, A.; Darszon, A.; Martinez-Mekler, G.

10.1101/2021.02.04.429865 — developmental biology — Posted on 2021-02-05

3460 CRISPR-Cas9 gene editing and rapid detection of gene-edited mutants using high-resolution melting in the apple scab fungus, Venturia inaequalis

Rocafort, M.; Arshed, S.; Hudson, D.; Singh, J.; Bowen, J. K.; Plummer, K. M.; Bradshaw, R. E.; Johnson, R. D.; Johnson, L. J.; Mesarich, C. H.

10.1101/2021.02.04.428760 — microbiology — Posted on 2021-02-05

3461 Nitroxoline as a promising alternative drug for the treatment of Lyme disease based on an in-vitro study

Alvarez-Manzo, H. S.; Zhang, Y.; Shi, W.; Zhang, Y.

10.1101/2021.02.04.429852 — microbiology — Posted on 2021-02-05

3462 Modeling ex vivo tumor-infiltrating lymphocyte expansion from established solid malignancies

Knochelmann, H. M.; Rivera-Reyes, A. M.; Wyatt, M. M.; Smith, A. S.; Chamness, R.; Dwyer, C. J.; Bobian, M.; Rangel Rivera, G. O.; Horton, J. D.; Lilly, M.; Rubinstein, M. P.; Neskey, D. M.; Paulos, C. M.

10.1101/2021.02.04.429846 — immunology — Posted on 2021-02-05

3463 Oxazepam and cognitive reappraisal: a randomised experiment

Nilsonne, G.; Tamm, S.; Golkar, A.; Olsson, A.; Sörman, K.; Howner, K.; Kristiansson, M.; Ingvar, M.; Petrovic, P.

10.1101/656355 — neuroscience — Posted on 2021-02-05

3464 Standing Variations Modeling Captures Inter-Individual Heterogeneity in a Deterministic Model of Prostate Cancer Response to Combination Therapy

Jain, H.; Sorribes, I. C.; Handelman, S. K.; Barnaby, J.; Jackson, T. L.

10.1101/2021.02.04.429807 — systems biology — Posted on 2021-02-05

3465 Nutritional Redundancy in Human Diet

Wang, X.-W.; Grodstein, F.; Bhupathiraju, S. N.; Sun, Q.; Zhang, X.; Hu, F.; Weiss, S. T.; Liu, Y.-Y.

10.1101/2021.02.04.429776 — systems biology — Posted on 2021-02-05

3466 Pharmacokinetics of Orally Administered GS-441524 in Dogs

Yan, V. C.; Khadka, S.; Arthur, K.; Ackroyd, J. J.; Georgiou, D. K.; Muller, F. L.

10.1101/2021.02.04.429674 — pharmacology and toxicology — Posted on 2021-02-05

3467 A theoretical approach to coupling the epithelial-mesenchymal transition (EMT) to extracellular matrix (ECM) stiffness via LOXL2

Deng, Y.; Chakraborty, P.; Jolly, M. K.; Levine, H.

10.1101/2021.02.04.429859 — cancer biology — Posted on 2021-02-05

3468 Targeting of TP53-independent cell cycle checkpoints overcomes FOLFOX resistance in Metastatic Colorectal Cancer

Behrenbruch, C.; Foroutan, M.; Lind, P.; Smith, J.; Grandin, M.; Cooper, B.; Shembrey, C.; Ramm, S.; Cowley, K.; Nikolic, I.; Liuu, J.; Cursons, J.; Millen, R.; Patch, A.-M.; Huntington, N. D.; Puisieux, A.; Michael, M.; Knowles, B.; Thomson, B. N.; Ramsay, R. G.; Grimmond, S. M.; Simpson, K.; Heriot, A. G.; Hollande, F.

10.1101/2021.02.04.429849 — cancer biology — Posted on 2021-02-05

3469 Uncovering Differences in Hydration Free Energies for Model Compound Mimics of Charged Sidechains of Amino Acids

Fossat, M. J.; Zeng, X.; Pappu, R. V.

10.1101/2021.02.04.429838 — biophysics — Posted on 2021-02-05

3470 Multi-task deep learning for concurrent prediction of protein structural properties

zhang, b.; Li, J.; Quan, L.; Lyu, Q.

10.1101/2021.02.04.429840 — bioinformatics — Posted on 2021-02-05

3471 Inference of genome 3D architecture by modeling overdispersion of Hi-C data

Varoquaux, N.; Noble, W. S.; Vert, J.-P.

10.1101/2021.02.04.429864 — bioinformatics — Posted on 2021-02-05

3472 Focused X-ray Luminescence Computed Tomography using a Continuous Scanning Scheme

Lun, M. C.; Fang, Y.; Li, C.

10.1101/2021.02.04.429805 — bioengineering — Posted on 2021-02-05

3473 Caprin-1 binding to the critical stress granule protein G3BP1 is regulated by pH

Schulte, T.; Panas, M. D.; Wiliams, L.; Kedersha, N.; Fleck, J. S.; Tan, T. J. C.; Olsson, A.; Morro, A. M.; Hanke, L.; Nilvebrant, J.; Giang, K. A.; Nygren, P.-A.; Anderson, P.; Achour, A.; McInerney, G. M.

10.1101/2021.02.05.429362 — biochemistry — Posted on 2021-02-05

3474 Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation

Zhang, L.; Mann, M.; Syed, Z.; Reynolds, H. M.; Tian, E.; Samara, N. L.; Zeldin, D. C.; Tabak, L. A.; Ten Hagen, K. G.

10.1101/2021.02.05.429982 — biochemistry — Posted on 2021-02-05

3475 Serological Profile Of Specific Antibodies Against Dominant Antigens Of SARS-CoV-2 In Chilean COVID-19 Patients.

Cereceda, K.; Gonzalez-Stegmaier, R.; Briones, J. L.; Selman, C.; Aguirre, A.; Valenzuela-Nieto, G.; Caglevic, C.; Gazitua, R.; Rojas-Fernandez, A.; Villaroel-Espindola, F.

10.1101/2021.02.05.429566 — biochemistry — Posted on 2021-02-05

3476 Human brain mitochondrial-nuclear cross-talk is cell-type specific and is perturbed by neurodegeneration

Fairbrother-Browne, A.; Ali, A. T.; Reynolds, R. H.; Garcia-Ruiz, S.; Zhang, D.; Chen, Z.; Ryten, M.; Hodgkinson, A.

10.1101/2021.02.04.429781 — genomics — Posted on 2021-02-05

3477 BGvar - a comprehensive resource for blood group immunogenetics

Rophina, M.; Pandhare, K.; Jadhao, S.; Nagaraj, S. H.; Scaria, V.

10.1101/2021.02.04.429861 — genomics — Posted on 2021-02-05

3478 Drosophila STING protein has a role in lipid metabolism.

Akhmetova, K.; Balasov, M.; Chesnokov, I.

10.1101/2021.02.04.429825 — genetics — Posted on 2021-02-05

3479 Expanded Asgard archaea shed new light on the origin of eukaryotes and support a 2-domain tree of life

Xie, R.; Wang, Y.; Huang, D.; Hou, J.; Li, L.; Hu, H.; Zhao, X.; Wang, F.

10.1101/2021.02.04.429862 — evolutionary biology — Posted on 2021-02-05

3480 Little evidence the standard genetic code is optimized for resource conservation

Rozhonova, H.; Payne, J. L.

10.1101/2021.02.04.429873 — evolutionary biology — Posted on 2021-02-05

3481 Evolutionary implications of recombination differences across diverging populations of Anopheles

Nelson, J. T.; Cornejo, O. E.; AG1000,

10.1101/2021.02.04.429659 — evolutionary biology — Posted on 2021-02-05

3482 Protein glycosylation is essential for SARS-CoV-2 infection

Casas-Sanchez, A.; Romero-Ramirez, A.; Hargreaves, E.; Patterson, E. I.; Hughes, G. L.; Zech, T.; Acosta-Serrano, A.

10.1101/2021.02.05.429940 — microbiology — Posted on 2021-02-05

3483 On the robustness of inference of association with the gut microbiota in stool, swab and mucosal tissue samples

Sun, S.; Zhu, X.; Huang, X.; Murff, H. J.; Ness, R. M.; Seidner, D. L.; Sorgen, A.; Blakley, I.; Yu, C.; Dai, Q.; Azcarate-Peril, M. A.; Shrubsole, M. J.; Fodor, A. A.

10.1101/2021.02.04.429844 — microbiology — Posted on 2021-02-05

3484 High fiber, whole foods dietary intervention alters the human gut microbiome but not fecal short-chain fatty acids

Oliver, A.; Chase, A. B.; Weihe, C.; Orchanian, S. B.; Riedel, S. F.; Hendrickson, C.; Lay, M.; Massimelli Sewall, J.; Martiny, J. B.; Whiteson, K.

10.1101/2021.02.04.429869 — microbiology — Posted on 2021-02-05

3485 Cellular management of Zinc in group B Streptococcus supports bacterial resistance against metal intoxication and promotes disseminated infection

Sullivan, M. J.; Goh, K. G.; Ulett, G. C.

10.1101/2021.02.04.429868 — microbiology — Posted on 2021-02-05

3486 Post-infection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection

Dampalla, C.; Zheng, J.; Perera, K.; Wong, L. Y. R.; Meyerholz, D.; Nguyen, H.; Kashipathy, M.; Battaile, K.; Lovell, S.; Kim, Y.; Perlman, S.; Groutas, W.; Chang, K.-O.

10.1101/2021.02.05.429937 — microbiology — Posted on 2021-02-05

3487 LncRNA SNHG1 suppresses LPS-induced acute lung injury by regulating miR-421/TIMP3 axis

Chen, Y.; Jiang, Z.; Tan, J.; Yuan, Y.; Shen, J.

10.1101/2021.02.04.429871 — immunology — Posted on 2021-02-05

3488 Collaboration between the Fab and Fc contribute to maximal protection against SARS-CoV-2 in nonhuman primates following NVX-CoV2373 subunit vaccine with Matrix-M™ vaccination

Gorman, M. J.; Patel, N.; Guebre-Xabier, M.; Zhu, A.; Atyeo, C.; Pullen, K.; Loos, C.; Goez-Gazi, Y.; Carrion, R.; Tian, J.-H.; Yuan, D.; Bowman, K.; Zhou, B.; Maciejewski, S.; McGrath, M.; Logue, J.; Frieman, M.; Montefiori, D.; Mann, C.; Schendel, S.; Amanat, F.; Krammer, F.; Saphire, E. O.; Lauffenburger, D. A.; Greene, A. M.; Portnoff, A. D.; Massare, M. J.; Ellingsworth, L.; Glenn, G.; Smith, G.; Alter, G.

10.1101/2021.02.05.429759 — immunology — Posted on 2021-02-05

3489 SARS-CoV-2 ORF7b: is a bat virus protein homologue a major cause of COVID-19 symptoms?

Fogeron, M.-L.; Montserret, R.; Zehnder, J.; Nguyen, M.-H.; Dujardin, M.; Brigandat, L.; Cole, L.; Ninot-Pedrosa, M.; Lecoq, L.; Meier, B. H.; Bockmann, A.

10.1101/2021.02.05.428650 — biochemistry — Posted on 2021-02-05

3490 Tuberculostearic acid (TSA)-containing phosphatidylinositols as reliable marker to determine Mycobacterium tuberculosis bacterial burden

Brandenburg, J.; Heyckendorf, J.; Waldow, F.; Zehethofer, N.; Linnemann, L.; Gisch, N.; Karakose, H.; Reimann, M.; Kranzer, K.; Kalsdorf, B.; Sanchez-Carballo, P.; Weinkauf, M.; Scholz, V.; Malm, S.; Homolka, S.; Gaede, K. I.; Herzmann, C.; Schaible, U. E.; Hölscher, C.; Reiling, N.; Schwudke, D.

10.1101/2021.02.04.429149 — biochemistry — Posted on 2021-02-05

3491 Catching SARS-CoV-2 by sequence hybridization: a comparative analysis

Rehn, A.; Braun, P.; Knuepfer, M.; Woelfel, R.; Antwerpen, M. H.; Walter, M. C.

10.1101/2021.02.05.429917 — genomics — Posted on 2021-02-05

3492 A dynamically-structured matrix population model based on renewal processes for accumulative development under variable environmental conditions

Erguler, K.; Mendel, J.

10.1101/2021.02.04.429697 — ecology — Posted on 2021-02-05

3493 A comparative study of isothermal nucleic acid amplification methods for SARS-CoV-2 detection at point-of-care

Tran, D. H.; Hoang, Q. C.; Tran, H. T.; Le, U. P.; Do, H. D. K.; Bui, L. M.; Nguyen, D. H.; Hoang, T. L.; Nguyen, T. T. T.; Nguyen, H. A.; Nguyen, T. H.; Cao, M. T.; Vu, V. V.; Phung, H. T. T.

10.1101/2020.05.24.113423 — molecular biology — Posted on 2021-02-05

3494 Bone Marrow-Derived AXL Tyrosine Kinase Promotes Mitogenic Crosstalk and Cardiac Allograft Vasculopathy

Glinton, K.; DeBerge, M.; Fisher, E.; Schroth, S.; Sinha, A.; Wang, J.-J.; Wasserstrom, J. A.; Ansari, M. J.; Zhang, Z. J.; Feinstein, M.; Leventhal, J.; Forbess, J.; Lomasney, J.; Luo, X.; Thorp, E. B.

10.1101/2021.02.04.429773 — immunology — Posted on 2021-02-05

3495 Discovery and Functional Characterization of Pro-growth Enhancers in Human Cancer Cells

Chen, P.; Fiaux, P.; Li, B.; Zhang, K.; Kubo, N.; Jiang, S.; Hu, R.; Wu, S.; Wang, M.; Wang, W.; McVicker, G. P.; Mischel, P.; Ren, B.

10.1101/2021.02.04.429675 — cancer biology — Posted on 2021-02-05

3496 Insertions and deletions as phylogenetic signal in alignment-free sequence comparison

Birth, N.; Dencker, T.; Morgenstern, B.

10.1101/2021.02.03.429685 — bioinformatics — Posted on 2021-02-05

3497 LevioSAM: Fast lift-over of alternate reference alignments

Mun, T.; Chen, N.-C.; Langmead, B.

10.1101/2021.02.05.429867 — bioinformatics — Posted on 2021-02-05

3498 High similarity among ChEC-seq datasets

Mittal, C.; Rossi, M. J.; Pugh, B. F.

10.1101/2021.02.04.429774 — genomics — Posted on 2021-02-05

3499 Brain transcriptional regulatory architecture and schizophrenia etiology converge between East Asian and European ancestral populations

Liu, S.; Chen, Y.; Wang, F.; Jiang, Y.; Duan, F.; Xia, Y.; Ning, Z.; Li, M.; Qiu, W.; Ma, C.; Yan, X.; Bao, A.; Dai, J.; Kopp, R. F.; Kuney, L.; Huang, J.; Xu, S.; Tang, B.; Liu, C.; Chen, C.

10.1101/2021.02.04.922880 — genetics — Posted on 2021-02-05

3500 Functional traits of carabid beetles reveal seasonal variation in community assembly in annual crops

Marrec, R.; Gross, N.; Badenhausser, I.; Dupeyron, A.; Caro, G.; Bretagnolle, V.; Roncoroni, M.; Gauffre, B.

10.1101/2021.02.04.429696 — ecology — Posted on 2021-02-05

3501 Akaike model selections of the vegetation structures and aerosphere factors in supporting lesser short nosed fruit bat (Cynopterus brachyotis Muller, 1838) populations in Asia mountainous paddy fields

Wibowo, A. A.

10.1101/2021.02.03.429676 — ecology — Posted on 2021-02-05

3502 Sublingual allergen immunotherapy with recombinant dog allergens prevents airway hyperresponsiveness in a model of asthma marked by vigorous TH2 and TH17 cell responses

Coquet, J. M.; Stark, J. M.; Liu, J.; Tibbitt, C. A.; Christian, M.; Ma, J.; Wintersand, A.; Murrell, B.; Adner, M.; Gronlund, H.; Gafvelin, G.

10.1101/2021.02.04.429730 — immunology — Posted on 2021-02-05

3503 Somatosensory innervation of healthy human oral tissues

Moayedi, Y.; Michlig, S.; Park, M.; Koch, A.; Lumpkin, E. A.

10.1101/2021.02.03.429664 — neuroscience — Posted on 2021-02-05

3504 Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience

Madsen, M. K.; Stenbaek, D. S.; Arvidsson, A.; Armand, S.; Marstrand-Jorgensen, M. R.; Johansen, S. S.; Linnet, K.; Ozenne, B.; Knudsen, G. M.; Fisher, P. M.

10.1101/2021.02.03.429325 — neuroscience — Posted on 2021-02-05

3505 The molecular clockwork of the suprachiasmatic nucleus is sufficient to co-ordinate phasing and stabilisation of sleep-wake cycles and enhance memory deficits in a clockless mouse

Maywood, E. S.; Chesham, J. E.; Winsky-Sommerer, R.; Hastings, M. H.

10.1101/2021.02.04.429717 — neuroscience — Posted on 2021-02-05

3506 Neuron-derived extracellular vesicles extracted from plasma show altered size and miRNA cargo as a function of antidepressant drug response

Saeedi, S.; Nagy, C.; Ibrahim, P.; Theroux, J.-F.; Wakid, M.; Fiori, L.; Yang, J.; Rotzinger, S.; Foster, J. A.; Mechawar, N.; Kennedy, S. H.; Turecki, G.

10.1101/2021.02.03.429557 — neuroscience — Posted on 2021-02-05

3507 Interaction between decision-making and interoceptive representations of bodily arousal in frontal cortex

Fujimoto, A.; Murray, E. A.; Rudebeck, P. H.

10.1101/2021.02.04.429750 — neuroscience — Posted on 2021-02-05

3508 A Quantitative Data-Driven Analysis (QDA) Framework for Resting-state fMRI: a Study of the Impact of Adult Age

Li, X.; Fischer, H.; Manzouri, A.; Maansson, K. N. T.; Li, T.-Q.

10.1101/2021.02.04.429600 — neuroscience — Posted on 2021-02-05

3509 Pulsed Focal ultrasound as a non-invasive method to deliver exosomes in the brain/stroke

Alptekin, A.; Khan, M. B.; Ara, R.; Rashid, M. H.; Kong, F.; Parvin, M.; Frank, J. A.; Chopra, R.; Dhandapani, K.; Arbab, A. S.

10.1101/2021.02.03.429621 — neuroscience — Posted on 2021-02-05

3510 JNK activation in TA and EDL muscle is load-dependent in rats receiving identical excitation patterns

Eftestoel, E.; Franchi, M. V.; Kasper, S.; Flueck, M.

10.1101/2021.02.04.429746 — physiology — Posted on 2021-02-05

3511 SARS-CoV-2 RECoVERY: a multi-platform open-source bioinformatic pipeline for the automatic construction and analysis of SARS-CoV-2 genomes from NGS sequencing data

De Sabato, L.; Vaccari, G.; Knijn, A.; Ianiro, G.; Di Bartolo, I.; Morabito, S.

10.1101/2021.01.16.425365 — bioinformatics — Posted on 2021-02-05

3512 Machine learning for single cell genomics data analysis

Raimundo, F.; Papaxanthos, L.; Vallot, C.; Vert, J.-P.

10.1101/2021.02.04.429763 — bioinformatics — Posted on 2021-02-05

3513 ASIGNTF: AGNOSTIC SIGNATURE USING NTF: A UNIVERSAL AGNOSTIC STRATEGY TO ESTIMATE CELL-TYPES ABUNDANCE FROM TRANSCRIPTOMIC DATASETS

Fogel, P.; Boldina, G.; Rocher, C.; Bettembourg, C.; Luta, G.; Auge, F.

10.1101/2021.02.04.429589 — bioinformatics — Posted on 2021-02-05

3514 GRAFIMO: variant and haplotype aware motif scanning on pangenome graphs

Tognon, M.; Bonnici, V.; Garrison, E.; Giugno, R.; Pinello, L.

10.1101/2021.02.04.429752 — bioinformatics — Posted on 2021-02-05

3515 Practical selection of representative sets of RNA-seq samples using a hierarchical approach

Tung, L. H.; Kingsford, C.

10.1101/2021.02.04.429817 — bioinformatics — Posted on 2021-02-05

3516 Ovine CD14- an immune response gene has a role against gastrointesinal nematode Haemonchus contortus -a novel report

Rawat, K.; Pal, A.; Banerjee, S.; Pal, A.; Mandal, S. C.; Batabyal, S.

10.1101/2021.02.04.429682 — genomics — Posted on 2021-02-05

3517 CRISPR interference identifies vulnerable cellular pathways with bactericidal phenotypes in Mycobacterium tuberculosis

McNeil, M.; Keighley, L. M.; Cook, J. R.; Cheung, C.-Y.; Cook, G.

10.1101/2021.02.04.429736 — genomics — Posted on 2021-02-05

3518 The prevalence, predominance, and metabolic potentials of Candidatus Prochlorobium terpiosii in the coral-killing sponge, Terpios hoshinota

Chen, Y.-H.; Chen, H.-J.; Yang, C.-Y.; Shiu, J.-H.; Hoh, D. Z.; Chiang, P.-W.; Chow, W. S.; Chen, C. A.; Shih, T.-H.; Lin, S.-H.; Yang, C.-M.; Reimer, J. D.; Hirose, E.; Iskandar, B. H.; Huang, H.; Schupp, P. J.; Tan, C. H. J.; Yamashiro, H.; Liao, M.-H.; Tang, S.-L.

10.1101/2021.02.04.429686 — ecology — Posted on 2021-02-05

3519 Evolution of butterfly-plant networks over time, as revealed by Bayesian inference of host repertoire

Braga, M. P.; Janz, N.; Nylin, S.; Ronquist, F.; Landis, M. J.

10.1101/2021.02.04.429735 — ecology — Posted on 2021-02-05

3520 Interleukin-33 regulates metabolic reprogramming of the retinal pigment epithelium in response to immune stressors.

Scott, L. M.; Vincent, E. E.; Hudson, N.; Neal, C.; Jones, N.; Lavelle, E.; Campbell, M.; Halestrap, A.; Dick, A. D.; Theodoropoulou, S.

10.1101/2021.02.04.429634 — immunology — Posted on 2021-02-05

3521 PML-Dependent Memory of Type I Interferon Treatment Results in a Restricted Form of HSV Latency

Suzich, J. B.; Cuddy, S. R.; Baidas, H.; Dochnal, S.; Ke, E.; Babnis, A.; Boutell, C.; Cliffe, A. R.

10.1101/2021.02.03.429616 — immunology — Posted on 2021-02-05

3522 New lessons on TDP-43 from the killifish N. furzeri

Louka, A.; Bagnoli, S.; Rupert, J.; Esapa, B.; Tartaglia, G. G.; Cellerino, A.; Pastore, A.; Terzibasi Tozzini, E.

10.1101/2021.02.04.429704 — neuroscience — Posted on 2021-02-05

3523 Five hours total sleep deprivation does not affect CA1 dendritic length or spine density

Brodin, A. T.; Gabulya, S.; Wellfelt, K.; Karlsson, T. E.

10.1101/2021.02.04.429550 — neuroscience — Posted on 2021-02-05

3524 Differentiation of human adult-derived stem cells towards a neural lineage involves a de-differentiation event prior to re-differentiation to neural phenotypes

Bueno, C.; Martinez-Morga, M.; Garcia-Bernal, D.; Moraleda, J. M.; Martinez, S.

10.1101/2021.02.04.429708 — neuroscience — Posted on 2021-02-05

3525 Phencyclidine-induced psychosis causes hypersynchronization and disruption of connectivity within prefrontal-hippocampal circuits that is rescued by antipsychotic drugs

Delgado-Sallent, C.; Nebot, P.; Gener, T.; Timplalexi, M.; Fath, A. B.; Puig, M. V.

10.1101/2021.02.03.429582 — neuroscience — Posted on 2021-02-05

3526 Spatio-temporal dynamics of visual information representation and transformation in brain networks resolving algorithmic functions

Jaworska, K.; van Rijsbergen, N. J.; Ince, R. A. A.; Schyns, P. G.

10.1101/2021.02.04.429372 — neuroscience — Posted on 2021-02-05

3527 Heartbeat-evoked potentials during interoceptive-exteroceptive integration are not consistent with precision-weighting

Banellis, L.; Cruse, D.

10.1101/2021.02.03.429610 — neuroscience — Posted on 2021-02-05

3528 Sublayer- and cell-type-specific neurodegenerative transcriptional trajectories in hippocampal sclerosis

Cid, E.; Marquez-Galera, A.; Valero, M.; Gal, B.; Medeiros, D. C.; Navarron, C. M.; Ballesteros-Esteban, L.; Reig-Viader, R.; Morales, A. V.; Fernandez-Lamo, I.; Gomez-Dominguez, D.; Sato, M.; Hayashi, Y.; Bayes, A.; Barco, A.; Lopez-Atalaya, J. P.; de la Prida, L. M.

10.1101/2021.02.03.429560 — neuroscience — Posted on 2021-02-05

3529 Human islet expression levels of Prostaglandin E2 synthetic enzymes, but not prostaglandin EP3 receptor, are positively correlated with markers of β-cell function and mass in non-diabetic obesity

Truchan, N. A.; Fenske, R. J.; Sandhu, H. K.; Weeks, A. M.; Patibandla, C.; Reuter, A.; Harrington, J. M.; Brill, A. L.; Peter, D. C.; Nall, R.; Daniels, M.; Pabich, S.; Punt, M.; Davis, D. B.; Kimple, M. E.

10.1101/2021.02.03.429205 — pharmacology and toxicology — Posted on 2021-02-05

3530 Fentanyl binds to the mu-opioid receptor via the lipid membrane and transmembrane helices

Sutcliffe, K. J.; Corey, R. A.; Charlton, S. J.; Sessions, R. B.; Henderson, G.; Kelly, E.

10.1101/2021.02.04.429703 — pharmacology and toxicology — Posted on 2021-02-05

3531 Dynamic blinking in the head of hardyhead silverside fish

Iwasaka, M.

10.1101/2021.02.03.429660 — biophysics — Posted on 2021-02-05

3532 Quantifying full-length circular RNAs in cancer

Yu, K. H.-O.; Shi, C. H.; Wang, B.; Chow, S. H.-C.; Chung, G. T.-Y.; Tan, K.-E.; Lim, Y.-Y.; Tsang, A. C.-M.; Lo, K.-W.; Yip, K. Y.

10.1101/2021.02.04.429722 — bioinformatics — Posted on 2021-02-05

3533 Extreme Phenotypic Diversity in Operant Responding for an Intravenous Cocaine or Saline Infusion in the Hybrid Mouse Diversity Panel

Bagley, J. R.; Khan, A. H.; Smith, D. J.; Jentsch, J. D.

10.1101/2021.02.03.429584 — animal behavior and cognition — Posted on 2021-02-05

3534 The genomic signature of wild-to-crop introgression during the domestication of scarlet runner bean (Phaseolus coccineus L.)

Guerra-Garcia, A.; Rojas-Barrera, I. C.; Ross-Ibarra, J.; Papa, R.; Piñero, D.

10.1101/2021.02.03.429668 — evolutionary biology — Posted on 2021-02-05

3535 Footprints to Singularity: A global population model explains late 20th century slow-down and predicts peak within ten years

Bystroff, C.

10.1101/2021.02.04.429734 — ecology — Posted on 2021-02-05

3536 Multi-modal artificial dura for simultaneous large-scale optical access and large-scaleelectrophysiology in non-human primate cortex

Griggs, D. J.; Khateeb, K.; Zhou, J.; Liu, T.; Wang, R. K.; Yazdan-Shahmorad, A.

10.1101/2021.02.03.429596 — neuroscience — Posted on 2021-02-05

3537 Connection Failure: Differences in White Matter Microstructure are associated with 5-HTTLPR but not with Risk-Seeking for Losses

Neukam, P. T.; Mueller, D. K.; Deza-Araujo, Y. I.; Pooseh, S.; Witt, S. H.; Rietschel, M.; Smolka, M. N.

10.1101/2021.02.03.429606 — neuroscience — Posted on 2021-02-05

3538 BioDynaMo: a general platform for scalable agent-based simulation

Breitwieser, L.; Hesam, A.; de Montigny, J.; Vavourakis, V.; Iosif, A.; Jennings, J.; Kaiser, M.; Manca, M.; Di Meglio, A.; Al-Ars, Z.; Rademakers, F.; Mutlu, O.; Bauer, R.

10.1101/2020.06.08.139949 — systems biology — Posted on 2021-02-05

3539 Development of a highly sensitive bioanalytical assay for the quantification of favipiravir.

Curley, P.; Neary, M.; Arshad, U.; Tatham, L.; Pertinez, H.; Box, H.; Rajoli, R. K. R.; Valentijn, A.; Sharp, J.; Rannard, S.; Owen, A.

10.1101/2021.02.03.429628 — pharmacology and toxicology — Posted on 2021-02-05

3540 Maize inbred line B96 is the source of large-effect loci for resistance to generalist but not specialist spider mites

Bui, H.; Greenhalgh, R.; Gill, G. S.; Ji, M.; Kurlovs, A. H.; Ronnow, C.; Lee, S.; Ramirez, R. A.; Clark, R. M.

10.1101/2021.02.04.429847 — genetics — Posted on 2021-02-05

3541 Preprinting the COVID-19 pandemic

Fraser, N.; Brierley, L.; Dey, G.; Polka, J. K.; Palfy, M.; Nanni, F.; Coates, J. A.

10.1101/2020.05.22.111294 — scientific communication and education — Posted on 2021-02-05

3542 Growth and grain yield of eight maize hybrids is aligned with water transport, stomatal conductance, and photosynthesis in a semi-arid irrigated system

Gleason, S. M.; Nalezny, L.; Hunter, C.; Bensen, R.; Chintamanani, S.; Comas, L. H.

10.1101/2021.02.04.429760 — plant biology — Posted on 2021-02-05

3543 The chicken or the egg? Plastome evolution and a novel loss of the inverted repeat in papilionoid legumes

Lee, C.; Choi, I.-S.; Cardoso, D.; de Lima, H. C.; Wojciechowski, M. F.; Jansen, R. K.; Ruhlman, T. A.

10.1101/2021.02.04.429812 — plant biology — Posted on 2021-02-05

3544 Direct acetylation of the conserved threonine of an immune regulator by bacterial effectors activates RPM1-dependent immunity in Arabidopsis

Choi, S.; Prokchorchik, M.; Lee, H.; Gupta, R.; Lee, Y.; Cho, B.; Kim, M.; Kim, S.-T.; Sohn, K. H.

10.1101/2021.02.05.426302 — plant biology — Posted on 2021-02-05

3545 The evolutionary making of SARS-CoV-2

Iruegas Lopez, R.; Dosch, J.; Sikora, M.; Hummer, G.; Covino, R.; Ebersberger, I.

10.1101/2021.01.29.428808 — evolutionary biology — Posted on 2021-02-05

3546 Return of a lost structure in the evolution of felid dentition revisited: A DevoEvo perspective on the irreversibility of evolution

Lynch, V. J.

10.1101/2021.02.04.429820 — evolutionary biology — Posted on 2021-02-05

3547 Development of the entorhinal cortex occurs via parallel lamination during neurogenesis.

Liu, Y.; Bergmann, T.; Mori, Y.; Peralvo Vidal, J. M.; Pihl, M.; Vasistha, N. A.; Dybdahl Thomsen, P.; Seemann, S. E.; Gorodkin, J.; Hyttel, P.; Khodosevich, K.; Witter, M.; Hall, V. J.

10.1101/2021.02.05.429755 — developmental biology — Posted on 2021-02-05

3548 Characterisation of protease activity during SARS-CoV-2 infection identifies novel viral cleavage sites and cellular targets for drug repurposing

Meyer, B.; Chiaravalli, J.; Gellenoncourt, S.; Brownridge, P.; Bryne, D. P.; Daly, L. A.; Walter, M.; Agou, F.; Chakrabarti, L. A.; Craik, C. S.; Eyers, C. E.; Eyers, P. A.; Gambin, Y.; Sierecki, E.; Verdin, E.; Vignuzzi, M.; Emmott, E.

10.1101/2020.09.16.297945 — microbiology — Posted on 2021-02-05

3549 Pharmacological rescue of the brain cortex phenotype in Tbx1 mouse mutants: significance for 22q11.2 deletion syndrome

favicchia, i.; flore, g.; lania, g.; baldini, a.; illingworth, e.

10.1101/2021.02.04.429794 — neuroscience — Posted on 2021-02-05

3550 High-Resolution Chemical Mapping and Microbial Identification of Rhizosphere using Correlative Microscopy

Bandara, C. D.; Schimdt, M.; Davoudpour, Y.; Stryhanyuk, H.; Richnow, H. H.; Musat, N.

10.1101/2021.02.05.429689 — plant biology — Posted on 2021-02-05

3551 ARGONAUTE10 is required for cell fate specification and the control of formative cell divisions in the Arabidopsis root meristem

El Arbi, N.; Schurholz, A.-K.; Schiffner, A.; Hidalgo Prados, I.; Bohme, F.; Wenzl, C.; Zhao, X.; Zeng, J.; Lohmann, J. U.; Wolf, S.

10.1101/2021.02.05.429893 — plant biology — Posted on 2021-02-05

3552 Tropism of SARS-CoV-2 in commonly used laboratory cell lines and their proteomic landscape during infection

Saccon, E.; Chen, X.; Mikaeloff, F.; Rodriguez, J. E.; Szekely, L.; Vinhas, B. S.; Krishnan, S.; Byrareddy, S.; Frisan, T.; Vegvari, A.; Mirazimi, A.; Neogi, U.; Gupta, S.

10.1101/2020.08.28.271684 — microbiology — Posted on 2021-02-05

3553 Transcriptomic profiling of atrial fibrillation canine models at disease onset

Leblanc, F. J. A.; Vahdati Hassani, F.; Qi, X.; Liesinger, L.; Naud, P.; Birner-Gruenberger, R.; Lettre, G.; Nattel, S.

10.1101/2021.02.04.429512 — genomics — Posted on 2021-02-05

3554 In vivo analysis of LEA-1 in C. elegans desiccation tolerance

Hibshman, J. D.; Goldstein, B.

10.1101/2021.02.04.429810 — genetics — Posted on 2021-02-05

3555 The epigenetic landscape in purified myonuclei from fast and slow muscles

Bengtsen, M.; Winje, I. M.; Eftestoel, E.; Landskron, J.; Sun, C.; Domanska, D.; Millay, D.; Meza-Zepeda, L.; Gundersen, K.

10.1101/2021.02.04.429545 — physiology — Posted on 2021-02-05

3556 Temporal and trophic partitioning promote coexistence between mesocarnivores in a Mediterranean landscape

Ferreiro-Arias, I.; Isla, J.; Jordano, P.; Benitez-Lopez, A.

10.1101/2020.11.05.370403 — ecology — Posted on 2021-02-05

3557 A Unified Framework for Lineage Tracing and Trajectory Inference

Forrow, A.; Schiebinger, G.

10.1101/2020.07.31.231621 — developmental biology — Posted on 2021-02-05

3558 Lymphatic PD-L1 expression restricts tumor-specific CD8+ T cell responses

Cousin, N.; Cap, S.; Dihr, M.; Tacconi, C.; Detmar, M.; Dieterich, L.

10.1101/2020.10.22.350934 — immunology — Posted on 2021-02-05

3559 ERAP2 increases the abundance of a peptide submotif highly selective for the Birdshot Uveitis-associated HLA-A29

Venema, W.; Hiddingh, S.; de Boer, J. H.; Claas, F.; Mulder, A.; Hollander, A. D.; Stratikos, E.; Sarkizova, S.; Veken, L. v. d.; Janssen, G.; Veelen, P. v.; Kuiper, J. J.

10.1101/2020.08.14.250654 — immunology — Posted on 2021-02-05

3560 Cholesterol recognition motifs in the transmembrane domain of the tyrosine kinase receptor family: the case for TRKB

Cannarozzo, C.; Fred, S. M.; Girych, M.; Biojone, C.; Enkavi, G.; Laukkanen, L.; Rog, T.; Vattulainen, I.; Casarotto, P. C.; Castren, E.

10.1101/734012 — neuroscience — Posted on 2021-02-05

3561 Plasticity of body axis polarity in Hydra regeneration under constraints

Livshits, A.; Garion, L.; Maroudas-Sacks, Y.; Shani-Zerbib, L.; Braun, E.; Keren, K.

10.1101/2021.02.04.429818 — biophysics — Posted on 2021-02-05

3562 Dopaminergic Modulation of Working Memory and Cognitive Flexibility in a Zebrafish Model of Aging-Related Cognitive Decline

Cleal, M.; Fontana, B. D.; Double, M.; Mezbrovschi, R.; Parcell, L.; Redhead, E. S.; Parker, M. O.

10.1101/2020.06.05.136077 — animal behavior and cognition — Posted on 2021-02-05

3563 A New 'Comprehensive' Annotation of Leucine-Rich Repeat-Containing Receptors in Rice

Gottin, C.; Dievart, A.; Summo, M.; Droc, G.; Perin, C.; Ranwez, V.; Chantret, N.

10.1101/2021.01.29.428842 — genomics — Posted on 2021-02-05

3564 Douglas fir and Norway spruce admixtures to beech forests along a site gradient in Northern Germany - Are soil nutrient conditions affected?

Foltran, E. C.; Lamersdorf, N.; Ammer, C.

10.1101/2020.09.25.313213 — ecology — Posted on 2021-02-05

3565 AlnC: An extensive database of long non-coding RNAs in Angiosperms

Singh, A.; Vivek, A.; Kumar, S.

10.1101/2021.02.04.429715 — bioinformatics — Posted on 2021-02-05

3566 Enzyme kinetics of CRISPR molecular diagnostics

Ramachandran, A.; Santiago, J. G.

10.1101/2021.02.03.429513 — bioengineering — Posted on 2021-02-05

3567 Genomic surveillance framework and global population structure for Klebsiella pneumoniae

Lam, M. M.; Wick, R. R.; Watts, S. C.; Cerdeira, L. T.; Wyres, K. L.; Holt, K. E.

10.1101/2020.12.14.422303 — genomics — Posted on 2021-02-05

3568 Ancestral mitochondrial apparatus derived from the bacterial type II secretion system

Horvathova, L.; Zarsky, V.; Panek, T.; Derelle, R.; Pyrih, J.; Motyckova, A.; Klapstova, V.; Vinopalova, M.; Markova, L.; Voleman, L.; Klimes, V.; Petru, M.; Vaitova, Z.; Cepicka, I.; Hryzakova, K.; Harant, K.; Gray, M. W.; Chami, M.; Guilvout, I.; Francetic, O.; Lang, B. F.; Vlcek, C.; Tsaousis, A. D.; Elias, M.; Dolezal, P.

10.1101/790865 — evolutionary biology — Posted on 2021-02-05

3569 The scaffold protein IQGAP1 links heat-induced stress signals to alternative splicing regulation in gastric cancer cells

Birladeanu, A.; Rogalska, M.; Potiri, M.; Papadaki, V.; Andreadou, M.; Kontoyiannis, D. L.; Lewis, J. D.; Erpapazoglou, Z.; Kafasla, P.

10.1101/2020.05.11.089656 — molecular biology — Posted on 2021-02-05

3570 Integrated tapered fibertrode for simultaneous control and readout of neural activity over small brain volumes with reduced light-induced artefacts

Spagnolo, B.; Peixoto, R.; Sileo, L.; Pisanello, M.; Pisano, F.; Assad, J. A.; Sabatini, B. L.; DeVittorio, m.; Pisanello, F.

10.1101/2020.07.31.226795 — neuroscience — Posted on 2021-02-05

3571 The immunosuppression of macrophages underlies the cardioprotective effects of catestatin (CST)

10.1101/2020.05.12.092254 — physiology — Posted on 2021-02-04

3572 ATP-dependent Clp protease subunit C1, HvClpC1, is a strong candidate gene for barley variegation mutant luteostrians as revealed by genetic mapping and genomic re-sequencing

Li, M.; Guo, G.; Pidon, H.; Melzer, M.; Prina, A. R.; Börner, T.; Stein, N.

10.1101/2021.02.04.429718 — genetics — Posted on 2021-02-04

3573 Genomic regions associated with Mycoplasma ovipneumoniae presence in nasal secretions of domestic sheep.

Mousel, M. R.; White, S. N.; Herndon, M. K.; Herndon, D. R.; Taylor, J. B.; Becker, G. M.; Murdoch, B. M.

10.1101/2021.02.04.429710 — genetics — Posted on 2021-02-04

3574 Follow-up of a hospital cohort during the first 3,530 suspected cases of COVID-19 in Sao Jose do Rio Preto, Sao Paulo, Brazil

Pacca, C. C.; Zini, N.; Versiani, A.; Lobl, E.; Milhim, B.; Campos, G.; Moraes, M.; dos Santos, T.; Dourado, F.; Moraes, B.; Rocha, L.; dos Santos, A.; Ruiz, L.; da Silva, G.; Nicesio, R.; Queiroz, F.; Salomao, M. L.; da Silva, N.; Negri, A.; Nogueira, M.; Estofolete, C.

10.1101/2021.02.04.429711 — molecular biology — Posted on 2021-02-04

3575 Chronic effects of short-term aerobic and anaerobic physical training on the ventral prostate of adult rats

Borges, R. M. R.; da Rocha, E. S.; de Andrade, E. M.; Nazare, N. E. d. S.; Araujo, P. A. O.; Cembraneli, P. N.; Ruiz, T. F. R.; Colleta, S. J.; Carlos, C. P.; Marques, V. B.; Taboga, S. R.; Gomes, F. d. C.; de Melo-Neto, J. S.

10.1101/2021.02.04.429709 — molecular biology — Posted on 2021-02-04

3576 Limitations of bacterial culture, viral PCR, and tulathromycin susceptibility test methods from upper respiratory tract samples in predicting the outcome of tulathromycin control or treatment of bovine respiratory disease in high risk feeder heifers

Sarchet, J. J.; Pollreisz, J. P.; Bechtol, D.; Blanding, M.; Saltman, R.; Taube, P.

10.1101/2021.02.04.429716 — microbiology — Posted on 2021-02-04

3577 Ventral hippocampus mediates the context-dependence of two-way signaled avoidance in male rats

Oleksiak, C. R.; Ramanathan, K. R.; Miles, O. W.; Perry, S. J.; Maren, S.; Moscarello, J. M.

10.1101/2021.02.04.429792 — neuroscience — Posted on 2021-02-04

3578 Increased abundance of nuclear HDAC4 impairs neuronal development and long-term memory

Main, P.; Tan, W. J.; Wheeler, D.; Fitzsimons, H. L.

10.1101/2021.02.04.429836 — neuroscience — Posted on 2021-02-04

3579 Does Food Insecurity exist among Farm households? Evidence from Ghana

Acheampong, P. P.; Obeng, E. A.; Opoku, M.; Brobbey, L.; Sakyiamah, B.

10.1101/2021.02.04.429712 — scientific communication and education — Posted on 2021-02-04

3580 Nonsense-mediated decay is highly stable across individuals and tissues.

Teran, N. A.; Nachun, D.; Eulalio, T.; Ferraro, N. M.; Smail, C.; Rivas, M. A.; Montgomery, S. B.

10.1101/2021.02.03.429654 — genomics — Posted on 2021-02-04

3581 New loci and neuronal pathways for resilience to heat stress in animals

Cheruiyot, E. K.; Haile-Mariam, M.; Cocks, B. G.; MacLeod, I. M.; Xiang, R.; Pryce, J. E.

10.1101/2021.02.04.429719 — genomics — Posted on 2021-02-04

3582 Functional classes of SNPs related to psychiatric disorders and behavioral traits contrast with those related to neurological disorders

Reimers, M.; Kendler, K. S.

10.1101/2021.02.04.429714 — genetics — Posted on 2021-02-04

3583 Plant genome response to incoming coding sequences: stochastic transcriptional activation independent of integration loci

Satoh, S.; Hata, T.; Takada, N.; Tachikawa, M.; Matsuo, M.; Kushnir, S.; Obokata, J.

10.1101/2020.11.28.401992 — evolutionary biology — Posted on 2021-02-04

3584 Proximity proteomics in a marine diatom reveals a putative cell surface-to-chloroplast iron trafficking pathway

Turnsek, J.; Brunson, J. K.; Martinez Viedma, M. d. P.; Deerinck, T. J.; Horak, A.; Obornik, M.; Bielinski, V. A.; Allen, A. E.

10.1101/806539 — cell biology — Posted on 2021-02-04

3585 {-}Cellular and biochemical response to chaperone versus substrate reduction therapies in neuropathic Gaucher disease{-}

Ivanova, M. M.; Dao, J.; kasaci, N.; Adewale, B.; Nazari, S.; Noll, L.; Fikry, J.; Sanati, A. H.; Goker-Alpan, O.

10.1101/2021.02.04.429713 — molecular biology — Posted on 2021-02-04

3586 Species-resolved sequencing of low-biomass microbiomes by 2bRAD-M

Sun, Z.; Huang, S.; Zhu, P.; Tzehau, L.; Zhao, H.; Lv, J.; Zhang, R.; Zhou, L.; Niu, Q.; Wang, X.; Zhang, M.; Jing, G.; Bao, Z.; Liu, J.; Wang, S.; Xu, J.

10.1101/2020.12.01.405647 — microbiology — Posted on 2021-02-04

3587 Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons

Ji, D. X.; Witt, K. C.; Kotov, D. I.; Margolis, S. R.; Louie, A.; Chevee, V.; Chen, K. J.; Dhaliwal, H. S.; Lee, A. Y.; Zamboni, D. S.; Kramnik, I.; Portnoy, D. A.; Darwin, K. H.; Vance, R. E.

10.1101/2020.01.07.897553 — immunology — Posted on 2021-02-04

3588 Recurrent circuit based neural population codes for stimulus representation and inference

Zhang, W.; Wu, S.; Josic, K.; Doiron, B.

10.1101/2020.11.18.389197 — neuroscience — Posted on 2021-02-04

3589 Enhanced preference for delayed rewards requires the basolateral amygdala and retrosplenial cortex

Lefner, M. J.; Magnon, A. P.; Gutierrez, J. M.; Lopez, M. R.; Wanat, M.

10.1101/2021.01.14.426754 — neuroscience — Posted on 2021-02-04

3590 Distinct neural representations of content and ordinal structure in auditory sequence memory

Fan, Y.; Han, Q.; Guo, S.; Luo, H.

10.1101/2020.12.05.412791 — neuroscience — Posted on 2021-02-04

3591 Organelle specific protein profiling with light mediated proximal labeling in living cells

Li, Z.

10.1101/2019.12.28.890095 — biochemistry — Posted on 2021-02-04

3592 Mechanoreceptor synapses in the brainstem shape the central representation of touch

Lehnert, B. P.; Santiago, C.; Huey, E. L.; Emanuel, A. J.; Renauld, S.; Africawala, N.; Alkislar, I.; Zheng, Y.; Bai, L.; Koutsioumpa, C.; Hong, J. T.; Magee, A. R.; Harvey, C. D.; Ginty, D. D.

10.1101/2021.02.02.429463 — neuroscience — Posted on 2021-02-04

3593 Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells.

Borriello, L.; Coste, A.; Sharma, V.; Karagiannis, G.; Lin, Y.; Wang, Y.; Ye, X.; Duran, C.; Chen, X.; Dalla, E.; Singh, D.; Oktay, M.; Condeelis, J.; Entenberg, D.

10.1101/2021.02.04.429798 — cancer biology — Posted on 2021-02-04

3594 Perturbation of BRMS1 interactome reveals pathways that impact cell migration

Zimmermann, R. C.; Sardiu, M. E.; Manton, C. A.; Miah, M. S.; Banks, C. A.; Adams, M. K.; Koestler, D. C.; Washburn, M. P.; Welch, D. R.

10.1101/2021.02.04.429764 — cancer biology — Posted on 2021-02-04

3595 Synergistic Cytotoxicity Between Cold Atmospheric Plasma and Pyrazolopyrimidinones Against Glioblastoma Cells

He, Z.; Charleton, C.; Devine, R.; Kelada, M.; Walsh, J. M. D.; Conway, G.; Gunes, S.; Mondala, J. R. M.; Tian, F.; Tiwari, B.; Kinsella, G. K.; Malone, R.; O'Shea, D.; Devereux, M.; Wang, W.; Cullen, P. J.; Stephens, J. C.; Curtin, J. F.

10.1101/2021.02.04.429831 — cancer biology — Posted on 2021-02-04

3596 Codon arrangement modulates MHC-I peptides presentation: implications for a SARS-CoV-2 peptide-based vaccine

Daouda, T.; Dumont-Lagace, M.; Feghaly, A.; Villani, A.-C.

10.1101/2021.02.04.429819 — bioinformatics — Posted on 2021-02-04

3597 Discovery of 17 conserved structural RNAs in fungi

Gao, W.; Jones, T. A.; Rivas, E.

10.1101/2021.02.01.429235 — bioinformatics — Posted on 2021-02-04

3598 Elucidation of global and local epidemiology of Salmonella Enteritidis through multilevel genome typing

Luo, L.; Payne, M.; Kaur, S.; Hu, D.; Cheney, L.; Octavia, S.; Wang, Q.; Tanaka, M. M.; Sintchenko, V.; Lan, R.

10.1101/2020.06.30.169953 — genomics — Posted on 2021-02-04

3599 Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells

Rouhani, F. J.; Zou, X.; Danecek, P.; Dias Amarante, T.; Koh, G.; Wu, Q.; Memari, Y.; Durbin, R.; Martincorena, I.; Bassett, A. R.; Gaffney, D.; Nik-Zainal, S.

10.1101/2021.02.04.429731 — genomics — Posted on 2021-02-04

3600 Extensive recombination-driven coronavirus diversification expands the pool of potential pandemic pathogens

Goldstein, S. A.; Brown, J.; Pedersen, B. S.; Quinlan, A. R.; Elde, N. C.

10.1101/2021.02.03.429646 — evolutionary biology — Posted on 2021-02-04

3601 High-throughput miRNA-sequencing of the human placenta: expression throughout gestation

Gonzalez, T. L.; Eisman, L. E.; Joshi, N. V.; Flowers, A. E.; Wu, D.; Wang, Y.; Santiskulvong, C.; Tang, J.; Buttle, R. A.; Sauro, E.; Clark, E. L.; DiPentino, R.; Jefferies, C. A.; Chan, J. L.; Lin, Y.; Zhu, Y.; Afshar, Y.; Tseng, H.-R.; Taylor, K.; Williams, J.; Pisarska, M. D.

10.1101/2021.02.04.429392 — developmental biology — Posted on 2021-02-04

3602 Conserved Cdk inhibitors show unique structural responses to tyrosine phosphorylation

Swadling, J. B.; Warnecke, T.; Morris, K. L.; Barr, A. R.

10.1101/2021.02.04.429742 — cell biology — Posted on 2021-02-04

3603 Site-specific O-glycosylation analysis of SARS-CoV-2 spike protein produced in insect and human cells

Bagdonaite, I.; Thompson, A. J.; Wang, X.; Soegaard, M.; Fougeroux, C.; Frank, M.; Diedrich, J. K.; Yates, J. R.; Salanti, A.; Vakhrushev, S. Y.; Paulson, J. C.; Wandall, H. H.

10.1101/2021.02.03.429627 — molecular biology — Posted on 2021-02-04

3604 Escherichia coli S2P family intramembrane protease RseP is engaged in the regulated sequential cleavages of FecR in the ferric citrate signaling

Yokoyama, T.; Niinae, T.; Tsumagari, K.; Imami, K.; Ishihama, Y.; Hizukuri, Y.; Akiyama, Y.

10.1101/2021.02.04.429786 — molecular biology — Posted on 2021-02-04

3605 Prioritization of antimicrobial targets by CRISPR-based oligo recombineering

Benns, H. J.; Storch, M.; Falco, J.; Fisher, F. R.; Alves, E.; Wincott, C. J.; Baum, J.; Baldwin, G. S.; Weerapana, E.; Tate, E. W.; Child, M. A.

10.1101/2021.02.04.429737 — microbiology — Posted on 2021-02-04

3606 Microbiota analysis of rural and urban surface waters and sediments in Bangladesh identifies human waste as driver of antibiotic resistance

McInnes, R. S.; uz-Zaman, M. H.; Alam, I. T.; Ho, S. F. S.; Moran, R. A.; Clemens, J. D.; Islam, M. S.; van Schaik, W.

10.1101/2021.02.04.429629 — microbiology — Posted on 2021-02-04

3607 An extracellular redox signal triggers calcium release and impacts the asexual development of Toxoplasma gondii

Alves, E.; Benns, H. J.; Magnus, L.; Dominicus, C.; Dobai, T.; Blight, J.; Wincott, C. J.; Child, M. A.

10.1101/2021.02.04.429728 — microbiology — Posted on 2021-02-04

3608 Genome-Wide CRISPR Screening Identifies BRD9 as a Druggable Component of Interferon-Stimulated Gene Expression and Antiviral Activity

Börold, J.; Eletto, D.; Busnadiego, I.; Mair, N. K.; Moritz, E.; Schiefer, S.; Schmidt, N.; Petric, P. P.; Wong, W. W.-L.; Schwemmle, M.; Hale, B. G.

10.1101/2021.02.04.429732 — immunology — Posted on 2021-02-04

3609 Glutamatergic dysfunction precedes neuron loss in cerebral organoids with MAPT mutation.

Bowles, K. R.; Silva, M. C.; Whitney, K.; Bertucci, T.; Garza, J.; Boles, N. C.; Strang, K. H.; Mahali, S.; Marsh, J. A.; Chen, C.; Pugh, D. A.; Liu, Y.; Berlind, J. E.; Lai, J. D.; Goderie, S. K.; Chowdhury, R.; Lotz, S.; Lane, K.; Onanuga, K.; Karch, C.; Ichida, J.; Crary, J. F.; Haggarty, S. J.; Goate, A. M.; Temple, S.

10.1101/2021.02.03.429623 — neuroscience — Posted on 2021-02-04

3610 Cortical Processing of Arithmetic and Simple Sentences in an Auditory Attention Task

Kulasingham, J. P.; Joshi, N. H.; Rezaeizadeh, M.; Simon, J. Z.

10.1101/2021.01.31.429030 — neuroscience — Posted on 2021-02-04

3611 Achieving natural behavior in a robot using neurally inspired hierarchical control

Barter, J. W.; Yin, H. H.

10.1101/2021.01.22.427862 — neuroscience — Posted on 2021-02-04

3612 How much does habitat isolation drive forest bird morphology?

Desrochers, A.; Noreau, F.

10.1101/2021.02.03.429615 — zoology — Posted on 2021-02-04

3613 Dissecting Response to Cancer Immunotherapy by Applying Bayesian Network Analysis to Flow Cytometry Data

Rodin, A. S.; Gogoshin, G.; Hilliard, S.; Wang, L.; Egelston, C.; Rockne, R. C.; Chao, J.; Lee, P. P.

10.1101/2020.06.14.151100 — systems biology — Posted on 2021-02-04

3614 Expanding the SiMPl plasmid toolbox for use with spectinomycin/streptomycin

Palanisamy, N.; Ballestin, J. B.; Di Ventura, B.

10.1101/2021.02.04.429595 — synthetic biology — Posted on 2021-02-04

3615 In-planta Gene Targeting in Barley using Cas9, with and without Geminiviral Replicons

Lawrenson, T.; Hinchliffe, A.; Clarke, M.; Morgan, Y.; Harwood, W.

10.1101/2021.02.04.429787 — plant biology — Posted on 2021-02-04

3616 High Affinity Chimeric Antigen Receptor with Cross-Reactive scFv to Clinically Relevant EGFR Oncogenic Isoforms

Thokala, R.; Binder, Z. A.; Zhang, L.; Zhang, J. V.; Zhang, D. Y.; Milone, M. C.; Ming, G.-L.; Song, H.; O'Rourke, D. M.

10.1101/2021.02.04.429797 — cancer biology — Posted on 2021-02-04

3617 Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer

Huang, H.; Wang, Z.; Zhang, Y.; Brekken, R. A.

10.1101/2021.02.04.429827 — cancer biology — Posted on 2021-02-04

3618 Missing the sweet spot: one of the two N-glycans on human Gb3/CD77 synthase curtails its activity

Mikolajczyk, K.; Bereznicka, A.; Szymczak-Kulus, K.; Haczkiewicz-Lesniak, K.; Szulc, B.; Olczak, M.; Rossowska, J.; Majorczyk, E.; Kapczynska, K.; Bovin, N. V.; Lisowska, M.; Kaczmarek, R.; Miazek, A.; Czerwinski, M.

10.1101/2021.02.04.429793 — biochemistry — Posted on 2021-02-04

3619 Genetically independent phenotype analysis identifies LPA and VCAM1 as drug targets for human ageing

Timmers, P. R. H. J.; Tiys, E. S.; Sakaue, S.; Akiyama, M.; Kiiskinen, T. T. J.; Zhou, W.; Hwang, S.-J.; Yao, C.; The Biobank Japan Project, ; FinnGen Study, ; Deelen, J.; Levy, D.; Ganna, A.; Kamatani, Y.; Okada, Y.; Joshi, P. K.; Wilson, J. F.; Tsepilov, Y. A.

10.1101/2021.01.22.427837 — genomics — Posted on 2021-02-04

3620 Low-pass sequencing increases the power of GWAS and decreases measurement error of polygenic risk scores compared to genotyping arrays

Li, J. H.; Mazur, C. A.; Berisa, T.; Pickrell, J. K.

10.1101/2020.04.29.068452 — genomics — Posted on 2021-02-04

3621 Large-scale analysis of SARS-CoV-2 spike-glycoprotein mutants demonstrates the need for continuous screening of virus isolates

Schroers, B.; Gudimella, R.; Bukur, T.; Roesler, T.; Loewer, M.; Sahin, U.

10.1101/2021.02.04.429765 — genomics — Posted on 2021-02-04

3622 Population genetics as a tool to elucidate pathogen reservoirs: Lessons from Pseudogymnoascus destructans, the causative agent of white-nose disease in bats

Fischer, N. M.; Altewischer, A.; Ranpal, S.; Dool, S. E.; Kerth, G.; Puechmaille, S. J.

10.1101/2021.02.04.429503 — ecology — Posted on 2021-02-04

3623 Sensory cilia act as a specialized venue for regulated EV biogenesis and signaling

Wang, J.; Nikonorova, I. A.; Silva, M. S.; Walsh, J. D.; Tilton, P. E.; Gu, A.; Barr, M. M.

10.1101/2021.02.04.429799 — cell biology — Posted on 2021-02-04

3624 Virome composition in marine fish revealed by meta-transcriptomics

Geoghegan, J. L.; Di Giallonardo, F.; Wille, M.; Ortiz-Baez, A. S.; Costa, V. A.; Ghaly, T.; Mifsud, J. C.; Turnbull, O. M.; Bellwood, D. R.; Williamson, J. E.; Holmes, E. C.

10.1101/2020.05.06.081505 — microbiology — Posted on 2021-02-04

3625 Targeting evolutionary conserved sequences circumvents the evolution of resistance in a viral gene drive against human cytomegalovirus

Walter, M.; Perrone, R.; Verdin, E.

10.1101/2021.01.08.425902 — microbiology — Posted on 2021-02-04

3626 Modeling intrahippocampal effects of anterior hippocampal hyperactivity relevant to schizophrenia using chemogenetic excitation of long axis-projecting mossy cells in the mouse dentate gyrus

Bauer, J. P.; Rader, S. L.; Joffe, M.; Kwon, W.; Quay, J.; Seanez, L.; Zhou, C.; Conn, P. J.; Lewis, A. S.

10.1101/2020.12.15.422938 — neuroscience — Posted on 2021-02-04

3627 Deficits in Behavioral and Neuronal Pattern Separation in Temporal Lobe Epilepsy

Madar, A. D.; Pfammatter, J. A.; Bordenave, J.; Plumley, E. I.; Ravi, S.; Cowie, M.; Wallace, E. P.; Hermann, B. P. D.; Maganti, R. K.; Jones, M. V.

10.1101/2020.02.13.948364 — neuroscience — Posted on 2021-02-04

3628 Distinct information-seeking modes in healthy and addicted individuals

Cogliati Dezza, I.; Noel, X.; Cleeremans, A.; Yu, A.

10.1101/2020.02.19.955989 — neuroscience — Posted on 2021-02-04

3629 Experimental corticosterone manipulation increases mature feather corticosterone content: implications for inferring avian stress history from feather analyses

Aharon-Rotman, Y.; Buttemer, W. A.; Koren, L.; Wynne-Edwards, K.

10.1101/2021.01.11.425815 — physiology — Posted on 2021-02-04

3630 Colonic epithelial adaptation to EGFR-independent growth induces induces chromosomal instability and is accelerated by prior injury

Chen, T.; Zeineldin, M.; Johnson, B.; Dong, Y.; Narkar, A.; Li, T.; Zhu, J.; Li, R.; Larman, T.

10.1101/2021.02.02.429426 — cancer biology — Posted on 2021-02-04

3631 RNAxplorer: Harnessing the Power of Guiding Potentials for Sampling RNA Landscapes

Entzian, G.; Hofacker, I.; Ponty, Y.; Lorenz, R.; Tanzer, A.

10.1101/2020.07.03.186882 — bioinformatics — Posted on 2021-02-04

3632 Natural diversity of honey bee (Apis mellifera) gut bacteriome in various climatic and seasonal states

Papp, M.; Bekesi, L.; Farkas, R.; Makrai, L.; Maroti, G.; Tözser, D.; Solymosi, N.

10.1101/2021.01.27.428438 — genomics — Posted on 2021-02-04

3633 Towards end-to-end disease prediction from raw metagenomic data

Queyrel, M.; Prifti, E.; Templier, A.; Zucker, J.-D.

10.1101/2020.10.29.360297 — genomics — Posted on 2021-02-04

3634 Ocular elongation and retraction in foveated reptiles

Rasys, A. M.; Pau, S. H.; Irwin, K. E.; Luo, S.; Trainor, P. A.; Menke, D. B.; Lauderdale, J. D.

10.1101/2021.01.20.427408 — developmental biology — Posted on 2021-02-04

3635 Godanti Bhasma (anhydrous CaSO4) induces massive cytoplasmic vacuolation and cell survival response through stimulation of LC3 Associated Phagocytosis (LAP)

Das, S. K.; Joshi, A.; Bisht, L.; Das, N.; Balkrishna, A.; Dhara, S.

10.1101/2020.02.01.930594 — cell biology — Posted on 2021-02-04

3636 Initial spindle formation at the oocyte center protects against incorrect kinetochore-microtubule attachment and aneuploidy in mice

Kincade, J. N.; Balboula, A. Z.

10.1101/2020.06.28.176594 — cell biology — Posted on 2021-02-04

3637 The Genetic Basis of phage susceptibility, cross-resistance and host-range in Salmonella

Adler, B. A.; Kazakov, A. E.; Zhong, C.; Liu, H.; Kutter, E.; Lui, L. M.; Nielsen, T. N.; Carion, H.; Deutschbauer, A. M.; Mutalik, V. K.; Arkin, A. P.

10.1101/2020.04.27.058388 — microbiology — Posted on 2021-02-04

3638 Modelling the effects of lymph node swelling on T-cell response

Johnson, S. C.; Frattolin, J.; Edgar, L. T.; Jafarnejad, M.; Moore, J. E.

10.1101/2020.06.19.161232 — immunology — Posted on 2021-02-04

3639 Informative neural representations of unseen objects during higher-order processing in human brains and deep artificial networks

Mei, N.; Santana, R.; Soto, D.

10.1101/2021.01.12.426428 — neuroscience — Posted on 2021-02-04

3640 A brief glimpse at a haptic target is sufficient for multisensory integration in reaching movements

Camponogara, I.; Volcic, R.

10.1101/2020.10.04.325712 — neuroscience — Posted on 2021-02-04

3641 A solution to temporal credit assignment using cell-type-specific modulatory signals

Liu, Y. H.; Smith, S. J.; Mihalas, S.; Shea-Brown, E.; Sumbul, U.

10.1101/2020.11.22.393504 — neuroscience — Posted on 2021-02-04

3642 A general decoding strategy explains the relationship between behavior and correlated variability

Ni, A. M.; Huang, C.; Doiron, B.; Cohen, M. R.

10.1101/2020.10.08.331850 — neuroscience — Posted on 2021-02-04

3643 The structural connectome constrains fast brain dynamics

Sorrentino, P.; Seguin, C.; Rucco, R.; Liparoti, M.; Troisi Lopez, E.; Bonavita, S.; Quarantelli, M.; Sorrentino, G.; Jirsa, V.; Zalesky, A.

10.1101/2020.11.25.393017 — neuroscience — Posted on 2021-02-04

3644 Photosynthesis dynamics and regulation sensed in the frequency domain

Nedbal, L.; Lazar, D.

10.1101/2021.02.03.429631 — plant biology — Posted on 2021-02-04

3645 MSM and sesame seed oil improve hyperlipidemia and PUFA metabolism in the db/db mouse

Volpe, C. K.; Lin, L.; Chapman, J.; Hamilton, D.; Yates, C. R.

10.1101/2020.12.30.424717 — pharmacology and toxicology — Posted on 2021-02-04

3646 CVTree: A Parallel Alignment-free Phylogeny and Taxonomy Tool based on Composition Vectors of Genomes

Zuo, G.

10.1101/2021.02.04.429726 — bioinformatics — Posted on 2021-02-04

3647 Microglia control cerebral blood flow and neurovascular coupling via P2Y12R-mediated actions

Csaszar, E.; Lenart, N.; Cserep, C.; Kornyei, Z.; Fekete, R.; Posfai, B.; Balazsfi, D.; Hangya, B.; Schwarcz, A. D.; Szollosi, D.; Szigeti, K.; Mathe, D.; West, B. L.; Sviatko, K.; Bras, A. R.; Mariani, J. C.; Kliewer, A.; Lenkei, Z.; Hricisak, L.; Benyo, Z.; Baranyi, M.; Sperlagh, B.; Menyhart, A.; Farkas, E.; Denes, A.

10.1101/2021.02.04.429741 — neuroscience — Posted on 2021-02-04

3648 Low doses of the organic insecticide spinosad trigger lysosomal defects, ROS driven lipid dysregulation and neurodegeneration in flies

Martelli, F.; Zuo, Z.; Wang, J.; Wong, C.-O.; Karagas, N. E.; Roessner, U.; Rupasinghe, T.; Venkatachalam, K.; Perry, T.; Batterham, P.; Bellen, H. J.

10.1101/2021.02.03.429672 — neuroscience — Posted on 2021-02-04

3649 Parallel Rap1>RalGEF>Ral and Ras signals sculpt the C. elegans nervous system

Mardick, J. I.; Rasmussen, N. R.; Wightman, B.; Reiner, D. J.

10.1101/2021.02.04.429158 — developmental biology — Posted on 2021-02-04

3650 Reparative macrophages regulate fibrosis in the infarcted myocardium by attenuating apoptosis and senescence of fibroblasts

Shiraishi, M.

10.1101/2021.01.29.428912 — molecular biology — Posted on 2021-02-04

3651 Identification of 370 genetic loci for age at first sex and birth linked to externalising behaviour

Mills, M. C.; Tropf, F. C.; Brazel, D. M.; van Zuydam, N.; Vaez, A.; eQTLGen Consortium, ; BIOS Consortium, ; Pers, T. H.; Snieder, H.; Perry, J. R. B.; Ong, K. K.; den Hoed, M.; Barban, N.; Day, F. R.; Human Reproductive Behaviour Consortium,

10.1101/2020.05.06.081273 — genetics — Posted on 2021-02-04

3652 Type-I interferon signatures in SARS-CoV-2 infected Huh7 cells

Chen, X.; Saccon, E.; Appelberg, K. S.; Mikaeloff, F.; Rodriguez, J. E.; Vinhas, B. S.; Frisan, T.; Vegvari, A.; Mirazimi, A.; Neogi, U.; Gupta, S.

10.1101/2021.02.04.429738 — microbiology — Posted on 2021-02-04

3653 Molnupiravir (EIDD-2801) inhibits SARS-CoV-2 replication and enhances the efficacy of favipiravir in a Syrian hamster infection model

Abdelnabi, R.; Foo, C. S.; Kaptein, S. J. F.; Zhang, X.; Langendries, L.; Vangeel, L.; Vergote, V.; Heylen, E.; Leyssen, P.; Dallmeier, K.; coelmont, l.; JOCHMANS, D.; Chatterjee, A. K.; De Jonghe, S.; Weynand, B.; Neyts, J.

10.1101/2020.12.10.419242 — microbiology — Posted on 2021-02-04

3654 The protein modifier SUMO is critical for Arabidopsis shoot meristem maintenance at warmer ambient temperatures

Hammoudi, V.; Beerens, B.; Jonker, M. J.; Helderman, T. A.; Vlachakis, G.; Giesbers, M.; Kwaaitaal, M.; van den Burg, H. A.

10.1101/2021.02.04.429700 — plant biology — Posted on 2021-02-04

3655 Bronchoalveolar lavage affects thorax computed tomography of healthy and SARS-CoV-2 infected rhesus macaques (Macaca mulatta)

Maaskant, A.; Meijer, L.; Bakker, J.; van Geest, L.; Zijlmans, D. G. M.; Langermans, J. A. M.; Verschoor, E. J.; Stammes, M. A.

10.1101/2021.02.04.429761 — biophysics — Posted on 2021-02-04

3656 Age-related susceptibility to insulin resistance is due to a combination of CPT1B decline and lipid overload

Vieira-Lara, M. A.; Dommerholt, M. B.; Zhang, W.; Blankestijn, M.; Wolters, J. C.; Abegaz, F.; van der Veen, Y.; van Dijk, T. H.; van Os, R.; Reijngoud, D.-J.; Jonker, J. W.; Kruit, J. K.; Bakker, B. M.

10.1101/2021.02.04.429529 — biochemistry — Posted on 2021-02-04

3657 Modulation of SARS-CoV-2 Spike-induced Unfolded Protein Response (UPR) in HEK293T cells by selected small chemical molecules

Balakrishnan, B.; Lai, K.

10.1101/2021.02.04.429769 — biochemistry — Posted on 2021-02-04

3658 Targeted in situ cross-linking mass spectrometry and integrative modeling reveal the architectures of Nsp1, Nsp2, and Nucleocapsid proteins from SARS-CoV-2

Slavin, M.; Zamel, J.; Zohar, K.; Eliyahu, S.; Braitbard, M.; Brielle, E.; Baraz, L.; Stolovich-Rain, M.; Friedman, A.; Wolf, D. G.; Rouvinski, A.; Linial, M.; Schneidman-Duhovny, D.; Kalisman, N.

10.1101/2021.02.04.429751 — biochemistry — Posted on 2021-02-04

3659 Alpha-arrestins Aly1 and Aly2 regulate trafficking of the glycerophosphoinositol transporter Git1 and impact phospholipid homeostasis

Robinson, B. P.; Hawbaker, S. E.; Chiang, A.; Jordahl, E. M.; Anaokar, S.; Nikiforov, A.; Bowman, R. W.; Ziegler, P.; McAtee, C. K.; Patton-Vogt, J.; O'Donnell, A. F.

10.1101/2021.02.04.429748 — cell biology — Posted on 2021-02-04

3660 A novel capsid protein network allows the characteristic inner membrane structure of Marseilleviridae giant viruses

Chihara, A.; Burton-Smith, R. N.; Kajimura, N.; Mitsuoka, K.; Okamoto, K.; Song, C.; Murata, K.

10.1101/2021.02.03.428533 — microbiology — Posted on 2021-02-04

3661 Speciation of the Mycobacterium tuberculosis complex using mass spectrometry: a proof-of-concept.

Robinne, S.; Saad, J.; Morsli, M.; Harouna, H. Z.; Tazerart, F.; Drancourt, M.; Baron, S. A.

10.1101/2021.02.04.429756 — microbiology — Posted on 2021-02-04

3662 In-depth characterization of HIV-1 reservoirs reveals links to viral rebound during treatment interruption

Cole, B.; Lambrechts, L.; Boyer, Z.; Noppe, Y.; De Scheerder, M.-A.; Eden, J.-S.; Vrancken, B.; Schlub, T.; Frenkel, L. M.; McLaughlin, S.; Palmer, S.; Vandekerckhove, L.

10.1101/2021.02.04.429690 — microbiology — Posted on 2021-02-04

3663 Sensitive visualization of SARS-CoV-2 RNA with CoronaFISH

Rensen, E. I.; Pietropaoli, S.; Weber, C.; Souquere, S.; Isnard, P.; Rabant, M.; Gibier, J.-B.; Simon-Loriere, E.; Rameix-Welti, M.-A.; Pierron, G.; Mueller, F.; Barba-Spaeth, G.; Zimmer, C.

10.1101/2021.02.04.429604 — microbiology — Posted on 2021-02-04

3664 The SARS-CoV-2 transcriptome and the dynamics of the S gene furin cleavage site in primary human airway epithelia

Zou, W.; Xiong, M.; Hao, S.; Zhang-Chen, E. Y.; Baumlin, N.; Kim, M. D.; Salathe, M.; Yan, Z.; Qiu, J.

10.1101/2021.02.03.429670 — microbiology — Posted on 2021-02-04

3665 Cold-acclimation induces life stage-specific responses in the cardiac proteome of Western painted turtles (Chrysemys picta bellii): implications for anoxia tolerance

Alderman, S. L.; Riggs, C. L.; Bullingham, O.; Gillis, T. E.; Warren, D. E.

10.1101/2021.02.03.429598 — physiology — Posted on 2021-02-04

3666 Analytical Performance of a Standardized Kit for Mass Spectrometry-based Measurements of Human Glycosaminoglycans

Tamburro, D.; Bratulic, S.; Shameh, S. A.; Soni, N. K.; Bacconi, A.; Maccari, F.; Galeotti, F.; Mattsson, K.; Volpi, N.; Nielsen, J.; Gatto, F.

10.1101/2021.02.04.429694 — biochemistry — Posted on 2021-02-04

3667 Electric fish use electrocommunication signals to fine tune relative dominance and access to resources

Raab, T.; Bayezit, S.; Erdle, S.; Benda, J.

10.1101/2021.02.04.429572 — animal behavior and cognition — Posted on 2021-02-04

3668 Selection on growth rate and local adaptation drive genomic adaptation during experimental range expansions in the protist Tetrahymena thermophila

Moerman, F.; Fronhofer, E. A.; Altermatt, F.; Wagner, A.

10.1101/2021.02.04.429706 — evolutionary biology — Posted on 2021-02-04

3669 Habitat complexity in organic olive orchards modulates the abundance of natural enemies but not the attraction to plant species

Alvarez, H. A.; Morente, M.; Ruano, F.

10.1101/2021.02.04.429588 — ecology — Posted on 2021-02-04

3670 Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant

Reuschl, A.-K.; Thorne, L.; Zuliani Alvarez, L.; Bouhaddou, M.; Obernier, K.; Hiatt, J.; Soucheray, M.; Turner, J.; Fabius, J.; Nguyen, G. T.; Swaney, D.; Rosales, R.; White, K. M.; Aviles, P.; Kirby, I. T.; Melnyk, J. E.; Shi, Y.; Zhang, Z.; Shokat, K.; Garcia-Sastre, A.; Jolly, C.; Towers, G. J.; Krogan, N. J.

10.1101/2021.01.24.427991 — microbiology — Posted on 2021-02-04

3671 Are specialised ABC transporters responsible for the circularisation of type I circular bacteriocins?

Vezina, B.; Rehm, B. H. A.; Smith, A. T.

10.1101/2020.12.23.424127 — microbiology — Posted on 2021-02-04

3672 Aquila_stLFR: diploid genome assembly basedstructural variant calling package for stLFRlinked-read

Liu, Y. H.; Grubbs, G. L.; Zhang, L.; Fang, X.; Dill, D. L.; Sidow, A.; Zhou, X.

10.1101/742239 — bioinformatics — Posted on 2021-02-04

3673 A model for pH coupling of the SARS-CoV-2 spike protein open/closed equilibrium.

Warwicker, J.

10.1101/2020.10.31.363176 — bioinformatics — Posted on 2021-02-04

3674 Slow phase-locked endogenous modulations support selective attention to sound

Kachlicka, M.; Laffere, A.; Dick, F.; Tierney, A. T.

10.1101/2021.02.03.429516 — neuroscience — Posted on 2021-02-04

3675 Individual variability in structural brain development from late childhood to young adulthood

Mills, K. L.; Siegmund, K. D.; Tamnes, C. K.; Ferschmann, L.; Bos, M. G. N.; Wierenga, L. M.; Luna, B.; Herting, M. L.

10.1101/2021.02.04.429671 — neuroscience — Posted on 2021-02-04

3676 De novo inter-regional coactivations of pre-configured local ensembles support memory

Miyawaki, H.; Mizuseki, K.

10.1101/2021.02.03.429684 — neuroscience — Posted on 2021-02-04

3677 The excitatory/inhibitory balance of synaptic transmission is impaired at higher extracellular Ca2+ concentrations in Scn1a+/- mouse model of Dravet syndrome

Uchino, K.; Kawano, H.; Tanaka, Y.; Adaniya, Y.; Asahara, A.; Deshimaru, M.; Kubota, K.; Watanabe, T.; Katsurabayashi, S.; Iwasaki, K.; Hirose, S.

10.1101/2021.02.04.429687 — neuroscience — Posted on 2021-02-04

3678 DMRscaler: A Scale-Aware Method to Identify Regions of Differential DNA Methylation Spanning Basepair to Multi-Megabase Features

Bondhus, L.; Wei, A.; ARBOLEDA, V. A.

10.1101/2021.02.03.428187 — genomics — Posted on 2021-02-04

3679 Systematic measurement of combination drug landscapes to predict in vivo treatment outcomes for tuberculosis

Larkins-Ford, J.; Greenstein, T.; Van, N.; Degefu, Y. N.; Olson, M. C.; Sokolov, A.; Aldridge, B. B.

10.1101/2021.02.03.429579 — microbiology — Posted on 2021-02-04

3680 Myelin biogenesis is associated with pathological ultrastructure that is resolved by microglia during development

Djannatian, M.; Weikert, U.; Safaiyan, S.; Wrede, C.; Deichsel, C.; Kislinger, G.; Ruhwedel, T.; Campbell, D. S.; van Ham, T. J.; Schmid, B.; Hegermann, J.; Möbius, W.; Schifferer, M.; Simons, M.

10.1101/2021.02.02.429485 — neuroscience — Posted on 2021-02-04

3681 Effects of tDCS Dose and Electrode Montage on regional cerebral blood flow and motor behavior

Shinde, A.; Lerud, K. D.; Munsch, F.; Alsop, D.; Schlaug, G.

10.1101/2021.02.02.429369 — neuroscience — Posted on 2021-02-04

3682 Systematic analysis of brain lactate and pH levels in 65 animal models related to neuropsychiatric conditions

Hagihara, H.; Shoji, H.; Sala, G.; Takamiya, Y.; Tanaka, M.; Hagino, Y.; Kotajima-Murakami, H.; Ikeda, K.; Otabi, H.; Toyoda, A.; Darwish, M.; Nishizono, H.; Takao, K.; Hori, K.; Hoshino, M.; Kim, H.; Kaang, B.-K.; Kohno, T.; Hattori, M.; Matsumoto, K.-i.; Okabe, S.; Ida-Eto, M.; Narita, M.; Fujisawa, H.; Sugimura, Y.; Numakawa, T.; Kunugi, H.; Tabuchi, K.; Katayama, Y.; Nakayama, K. I.; Matsushita, M.; Inazawa, J.; Yamamoto, T.; Nakamura, H.; Goshima, Y.; Hatakama, H.; Asaoka, N.; Kaneko, S.; Tatsukawa, T.; Raveau, M.; Yamakawa, K.; Ihara, M.; Yamanishi, K.; Sapkota, K.; Nakazawa, K.; Graef,

10.1101/2021.02.02.428362 — neuroscience — Posted on 2021-02-04

3683 Protein lactylation induced by neural excitation

Hagihara, H.; Shoji, H.; Otabi, H.; Toyoda, A.; Katoh, K.; Namihira, M.; Miyakawa, T.

10.1101/2021.02.02.428370 — neuroscience — Posted on 2021-02-04

3684 Photosynthesis dynamics and regulation sensed in the frequency domain

Nedbal, L.; Lazar, D.

10.1101/2021.02.03.429631 — plant biology — Posted on 2021-02-04

3685 Split-HaloTag Imaging Assay for Sophisticated Microscopy of Protein-Protein Interactions in planta

Minner-Meinen, R.; Weber, J. N.; Albrecht, A.; Matis, R.; Behnecke, M.; Tietge, C.; Frank, S.; Schulze, J.; Buschmann, H.; Walla, P. J.; Mendel, R. R.; Haensch, R.; Kaufholdt, D.

10.1101/2020.06.08.139378 — plant biology — Posted on 2021-02-04

3686 In vivo Evaluation and in silico Prediction of the Toxicity of Drepanoalpha Hard capsules

Gbolo Zoawe, B.; Ngbolua Koto-te-Nyiwa, J.-P.; Tshibangu Sha-Tshibey, D.; Memvanga Bondo, P.; Tshilanda Dinangayi, D.; Matondo, A.; Kilembe Thambwe, J.; Lebwaze Masamba, B.; Nachtergael, A.; Mpiana Tshimankinda, P.; Duez, P.

10.1101/2020.12.03.411124 — pharmacology and toxicology — Posted on 2021-02-04

3687 Single molecule tracking of AMPA receptors shows the role of synaptic insertion during maintenance of chemical LTP

Jin, C.; Ja, S.-S.; Ge, P.; Chun, H. J.; Selvin, P. R.

10.1101/2021.02.04.429665 — biophysics — Posted on 2021-02-04

3688 Differential dropout analysis captures biological variation in single-cell RNA sequencing data

Bouland, G. A.; Mahfouz, A.; Reinders, M. J. T.

10.1101/2021.02.01.429187 — bioinformatics — Posted on 2021-02-04

3689 Microtissue geometry and cell-generated forces drive patterning of liver progenitor cell differentiation in 3D

Berg, I. C.; Mohagheghian, E.; Habing, K.; Wang, N.; Underhill, G. H.

10.1101/2020.10.28.355875 — bioengineering — Posted on 2021-02-04

3690 A protein-based biosensor for detecting calcium by magnetic resonance imaging

Ozbakir, H. F.; Miller, A. D. C.; Fishman, K.; Martins, A. F.; Kippin, T. E.; Mukherjee, A.

10.1101/2021.02.04.429691 — bioengineering — Posted on 2021-02-04

3691 The yeast eIF2 kinase Gcn2 facilitates H2O2-mediated feedback inhibition of both protein synthesis and ER oxidative folding during recombinant protein production

Gast, V.; Campbell, K.; Picazo, C.; Engqvist, M. K. M.; Siewers, V.; Molin, M.

10.1101/2021.02.03.429681 — bioengineering — Posted on 2021-02-04

3692 S-acylation targets ORAI1 channels to lipid rafts for efficient Ca2+ signaling by T cell receptors at the immune synapse

Carreras-Sureda, A.; Abrami, L.; JI-Hee, K.; Frieden, M.; Didier, M.; van der Goot, F. G.; Demaurex, N.

10.1101/2021.02.03.429577 — biochemistry — Posted on 2021-02-04

3693 The mutation profile of SARS-CoV-2 is primarily shaped by the host antiviral defense

Azgari, C.; Kilinc, Z.; Turhan, B.; Circi, D.; Adebali, O.

10.1101/2021.02.02.429486 — evolutionary biology — Posted on 2021-02-04

3694 Protein structure without structure determination: direct coupling analysis based on in vitro evolution

Fantini, M.; Lisi, S.; de los Rios, P.; Cattaneo, A.; Pastore, A.

10.1101/582056 — evolutionary biology — Posted on 2021-02-04

3695 Phylogenetically conserved peritoneal fibrosis response to an immunologic adjuvant in ray-finned fishes

Vrtilek, M.; Bolnick, D. I.

10.1101/2020.07.08.191601 — evolutionary biology — Posted on 2021-02-04

3696 Living with relatives offsets the harm caused by pathogens in natural populations

Bensch, H. M.; O'Connor, E. A.; Cornwallis, C. K.

10.1101/2021.02.02.429439 — ecology — Posted on 2021-02-04

3697 Positive but variable effects of crop diversification on biodiversity and ecosystem services

Beillouin, D.; Ben-Ari, T.; Malezieux, E.; Seufert, V.; Makowski, D.

10.1101/2020.09.30.320309 — ecology — Posted on 2021-02-04

3698 Artificial Intelligence Approaches to Assessing Primary Cilia

Bansal, R.; Engle, S. E.; Kamba, T. K.; Brewer, K.; Lewis, W. R.; Berbari, N. F.

10.1101/2021.02.03.429602 — cell biology — Posted on 2021-02-04

3699 A WDR35-dependent coatomer transports ciliary membrane proteins from the Golgi to the cilia

Quidwai, T.; Hall, E. A.; Keighren, M. A.; Leng, W.; Kiesel, P.; Wells, J. N.; Murphy, L. C.; Marsh, J. A.; Pigino, G.; Mill, P.

10.1101/2020.12.22.423978 — cell biology — Posted on 2021-02-04

3700 A novel adhesive complex at the base of intestinal microvilli

Hartmann, C.; Thuering, E.-M.; Michels, B. E.; Pajonczyk, D.; Leussink, S.; Greune, L.; Brinkmann, F.; Glaesner-Ebnet, M.; Wardelmann, E.; Zobel, T.; Schmidt, M. A.; Gerke, V.; Ebnet, K. T.

10.1101/2021.01.25.428038 — cell biology — Posted on 2021-02-04

3701 Mutation of lipoprotein processing pathway gene lspA or inhibition of LspA activity by globomycin increases MRSA resistance to -lactam antibiotics

Fingleton, C.; Zeden, M. S.; Bueno, E.; Cava, F.; O'Gara, J. P.

10.1101/2021.02.03.429649 — microbiology — Posted on 2021-02-04

3702 Spatial and temporal plasticity of neoantigen-specific T-cell responses bases on characteristics associated to antigen and TCR

Braeunlein, E.; Lupoli, G.; Abalrous, E. T.; de Andrade Kraetzig, N.; Gosmann, D.; Fuechsl, F.; Wietbrock, L.; Lange, S.; Engleitner, T.; Lan, H.; Audehm, S.; Effenberger, M.; Boxberg, M.; Steiger, K.; Chang, Y.; Yu, K.; Atay, C.; Bassermann, F.; Weichert, W.; Busch, D. H.; Rad, R.; Freund, C.; Antes, I.; Krackhardt, A. M.

10.1101/2021.02.02.428777 — immunology — Posted on 2021-02-04

3703 DPSleep: Open-Source Longitudinal Sleep Analysis From Accelerometer Data

Rahimi Eichi, H.; Coombs, G.; Vidal Bustamante, C. M.; Onnela, J.-P.; Baker, J. T.; Buckner, R. L.

10.1101/2021.02.02.429455 — neuroscience — Posted on 2021-02-04

3704 Consciously detecting and recognizing a stimulus without knowing what it looks like

Rimsky-Robert, D.; Lisi, M.; Nous, C.; Sergent, C.

10.1101/2021.02.02.429359 — neuroscience — Posted on 2021-02-04

3705 Epigenetic therapy to enhance therapeutic effects of PD-1 inhibition in uveal melanoma

Sah, V. R.; Jespersen, H.; Karlsson, J.; Lindberg, M.; Nilsson, L. M.; Ny, L.; Nilsson, J. A.

10.1101/2021.02.04.429575 — cancer biology — Posted on 2021-02-04

3706 CDK4/6 inhibitors induce replication stress to cause long-term cell cycle withdrawal

Crozier, L.; Foy, R.; Mouery, B. L.; Whitaker, R. H.; Corno, A.; Spanos, C.; Ly, T.; Cook, J. G.; Saurin, A. T.

10.1101/2021.02.03.428245 — cancer biology — Posted on 2021-02-04

3707 Essential role of CFAP53 in sperm flagellum biogenesis

Wu, B. b.; Yu, X. c.; Liu, C.; Wang, L.; Huang, T.; Lu, G.; Chen, Z.-J.; Li, W.; Liu, H. b.

10.1101/2021.02.04.429673 — developmental biology — Posted on 2021-02-04

3708 Tig1 regulates proximo-distal identity during salamander limb regeneration

Oliveira, C. R.; Knapp, D.; Elewa, A.; Gonzalez Malagon, S. G.; Gates, P. B.; Petzold, A.; Arce, H.; Cordoba, R.; Chara, O.; Tanaka, E. M.; Simon, A.; Yun, M.

10.1101/2021.02.03.428234 — developmental biology — Posted on 2021-02-04

3709 The C. elegans DAF-19M module: a shift from general ciliogenesis to ciliary and behavioral specialization

Ahn, S.; Yang, H.; Son, S.; Park, D.; Yim, H.; Swoboda, P.; LEE, J.

10.1101/2021.02.03.429678 — molecular biology — Posted on 2021-02-04

3710 Imaging transmembrane dynamics of biomolecules at live cell plasma membranes using quenchers in extracellular environment

Hou, W.; Ma, D.; He, X.; Han, W.; Ma, J.; Wang, H.; Xu, C.; Xie, R.; Fan, Q.-h.; Ye, F.; Hu, S.; Lu, Y.; Li, M.

10.1101/2020.08.30.266148 — biophysics — Posted on 2021-02-04

3711 Revisiting giraffe photo-identification using deep learning and network analysis

Miele, V.; Dussert, G.; Spataro, B.; Chamaille-Jammes, S.; Allaine, D.; Bonenfant, C.

10.1101/2020.03.25.007377 — ecology — Posted on 2021-02-04

3712 Establishing regulated unconventional secretion for production of heterologous proteins

Hussnaetter, K. P. P.; Philipp, M.; Muentjes, K.; Feldbruegge, M.; Schipper, K.

10.1101/2021.02.02.429340 — molecular biology — Posted on 2021-02-04

3713 My voice therefore I spoke: sense of agency over speech enhanced in hearing self-voice

Ohata, R.; Asai, T.; Imaizumi, S.; Imamizu, H.

10.1101/2020.11.20.392308 — neuroscience — Posted on 2021-02-04

3714 Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency

De La Rossa, A.; Laporte, M. H.; Astori, S.; Marissal, T.; Montessuit, S.; Sheshadri, P.; Ramos-Fernández, E.; Mendez, P.; Khani, A.; Quairiaux, C.; Taylor, E.; Rutter, J.; Nunes, J. M.; carleton, a.; Duchen, M.; Sandi, C.; Martinou, J.-C.

10.1101/2020.12.22.423903 — neuroscience — Posted on 2021-02-04

3715 Highly efficient CRISPR-mediated homologous recombination via NHEJ deficiency rather than HDR factors overexpression in Populus

Movahedi, A.; Wei, H.; Chen, Z.-H.; Sun, W.; Zhang, J.; Li, D.; Yang, L.; Zhuge, Q.

10.1101/2020.07.04.188219 — plant biology — Posted on 2021-02-04

3716 Reciprocalspaceship: A Python Library for Crystallographic Data Analysis

Greisman, J. B.; Dalton, K. M.; Hekstra, D. R.

10.1101/2021.02.03.429617 — biophysics — Posted on 2021-02-04

3717 RAD51 nuclear recruitment and inhibition towards innovative strategies against pancreatic cancer

Schipani, F.; Manerba, M.; Marotta, R.; Gennari, A.; Rinaldi, F.; Armirotti, A.; Roberti, M.; Di Stefano, G.; Rocchia, W.; Tirelli, N.; Girotto, S.; Cavalli, A.

10.1101/2021.02.03.429564 — biophysics — Posted on 2021-02-04

3718 SplicingFactory - Splicing diversity analysis for transcriptome data

Szikora, P.; Por, T.; Sebestyen, E.

10.1101/2021.02.03.429568 — bioinformatics — Posted on 2021-02-03

3719 NanoMethViz: an R/Bioconductor package for visualizing long-read methylation data

Su, S.; Gouil, Q.; Blewitt, M. E.; Cook, D.; Hickey, P. F.; Ritchie, M. E.

10.1101/2021.01.18.426757 — bioinformatics — Posted on 2021-02-04

3720 PIGNON: A protein-protein interaction-guided functional enrichment analysis for quantitative proteomics

Nadeau, R.; Byvsheva, A.; Lavallee-Adam, M.

10.1101/2021.02.03.429592 — bioinformatics — Posted on 2021-02-04

3721 Using de novo assembly to identify structural variation of complex immune system gene regions

Zhang, J.-Y.; Roberts, H.; Flores, D. S. C.; Cutler, A. J.; Brown, A. C.; Whalley, J. P.; Mielczarek, O.; Buck, D.; Lockstone, H.; Xella, B.; Oliver, K.; Corton, C.; Betteridge, E.; Bashford-Rogers, R.; Knight, J. C.; Todd, J. A.; Band, G.

10.1101/2021.02.03.429586 — bioinformatics — Posted on 2021-02-04

3722 Automatic Identification and Avoidance of Axon Bundle Activation for Epiretinal Prosthesis

Tandon, P.; Bhaskar, N.; Shah, N.; Madugula, S.; Grosberg, L. E.; Fan, V. H.; Hottowy, P.; Sher, A.; Litke, A. M.; Chichilnisky, E. J.; Mitra, S.

10.1101/2021.02.03.429317 — bioengineering — Posted on 2021-02-03

3723 High-throughput selection of microalgae based on biomass accumulation rates in production environments using PicoShell Particles

van Zee, M.; de Rutte, J.; Rumyan, R.; Williamson, C.; Burnes, T.; Radakovits, R.; Sonico Eugenio, A.; Badih, S.; Lee, D.-H.; Archang, M.; Di Carlo, D.

10.1101/2021.02.03.429271 — bioengineering — Posted on 2021-02-04

3724 REHE: Fast Variance Components Estimation for Linear Mixed Models

Yue, K.; Ma, J.; Thornton, T.; Shojaie, A.

10.1101/2021.02.03.429643 — genetics — Posted on 2021-02-03

3725 In vivo identification and validation of novel potential predictors for human cardiovascular diseases

Hammouda, O. T.; Yue, M.; Kaul, V.; Thumberger, T.; Wittbrodt, J.

10.1101/2021.02.03.429563 — genetics — Posted on 2021-02-04

3726 Two transcriptionally distinct pathways drive female development in a reptile with both genetic and temperature dependent sex determination

Whiteley, S. L.; Holleley, C. E.; Wagner, S.; Blackburn, J.; Deveson, I. W.; Marshall Graves, J. A.; Georges, A.

10.1101/2021.02.03.429474 — genetics — Posted on 2021-02-04

3727 Cryptic microgeographic variation in responses of larval Atlantic cod to warmer temperatures

Oomen, R. A.; Juliussen, E.; Olsen, E. M.; Knutsen, H.; Jentoft, S.; Hutchings, J. A.

10.1101/2021.02.03.429645 — evolutionary biology — Posted on 2021-02-03

3728 Horizontal transfer of microbial toxin genes to gall midge genomes

Verster, K. I.; Tarnopol, R. L.; Akalu, S. M.; Whiteman, N. K.

10.1101/2021.02.03.429655 — evolutionary biology — Posted on 2021-02-04

3729 Identifying nearshore nursery habitats for sharks in the Eastern Tropical Pacific from fisheries landings and interviews

Lopez Angarita, J.; Villate, M.; Diaz, J. M.; Cubillos, J. C.; Tilley, A.

10.1101/2021.02.03.429561 — ecology — Posted on 2021-02-03

3730 Thermal flexibility is a repeatable mechanism to cope with environmental stressors in a passerine bird

Robertson, J. K.; Mastromonaco, G. F.; Burness, G.

10.1101/2021.02.03.429657 — ecology — Posted on 2021-02-03

3731 Ground cover presence in organic olive orchards affects the interaction of natural enemies against Prays oleae, promoting an effective egg predation

Alvarez, H. A.; Jimenez-Munoz, R.; Morente, M.; Campos, M.; Ruano, F.

10.1101/2021.02.03.429537 — ecology — Posted on 2021-02-04

3732 Exotic bifurcations in three connected populations with Allee effect

Rost, G.; Sadeghimanesh, A.

10.1101/2021.02.03.429609 — ecology — Posted on 2021-02-04

3733 14-3-3ζ-depletion impairs mammary gland development in the mouse

Poltavets, V.; Esmaeili, Z.; Boyle, S. T.; Ramshaw, H. S.; Lopez, A. F.; Kochetkova, M.; Samuel, M. S.

10.1101/2021.02.03.425513 — cell biology — Posted on 2021-02-03

3734 A modular platform for engineering function ofnatural and synthetic biomolecular condensates

Lasker, K.; Boeynaems, S.; Lam, V.; Stainton, E.; Jacquemyn, M.; Daelemans, D.; Villa, E.; Holehouse, A. S.; Gitler, A.; Shapiro, L.

10.1101/2021.02.03.429226 — cell biology — Posted on 2021-02-03

3735 Inhibiting glycogen synthase kinase 3 suppresses TDP-43-mediated neurotoxicity in a caspase-dependant manner

White, M. A.; Massenzio, F.; Li, X.; Coleman, M. P.; Barmada, S. J.; Sreedharan, J.

10.1101/2021.02.03.429569 — neuroscience — Posted on 2021-02-03

3736 Delta-range coupling between prefrontal cortex and hippocampus supported by respiratory rhythmic input from the olfactory bulb in freely behaving rats

Mofleh, R.; Kocsis, B.

10.1101/2020.05.04.077461 — neuroscience — Posted on 2021-02-04

3737 Examination of digital images from Macaulay Library to determine avian molt strategies: A case study on molts and plumages in eight species of North American hummingbirds

Pyle, P.

10.1101/2021.02.03.429637 — zoology — Posted on 2021-02-03

3738 How much does habitat isolation drive forest bird morphology?

Desrochers, A.; Noreau, F.

10.1101/2021.02.03.429615 — zoology — Posted on 2021-02-03

3739 Knowledge and Awareness of coronavirus disease 2019 (COVID-19) among Chinese dental students----a comparison study.

Shi, b.; Deng, C.; Ma, H.; Shou, Y.; Zhao, Y.; Li, Y.

10.1101/2021.02.03.429522 — scientific communication and education — Posted on 2021-02-03

3740 Plant pathogens convergently evolved to counteract redundant nodes of an NLR immune receptor network

Derevnina, L.; Contreras, M. P.; Adachi, H.; Upson, J.; Vergara Cruces, A.; Xie, R.; Sklenar, J.; Menke, F. L.; Mugford, S. T.; MacLean, D. T.; Ma, W.; Hogenhout, S. A.; Goverse, A.; Maqbool, A.; Wu, C.-h.; Kamoun, S.

10.1101/2021.02.03.429184 — plant biology — Posted on 2021-02-03

3741 Molecular diagnosis and prognosis of cancers of unknown-primary (CUPs): progress from a microRNA-based droplet digital PCR assay

Laprovitera, N.; Riefolo, M.; Porcellini, E.; Durante, G.; Garajova, I.; Vasuri, F.; Aigelsreiter, A.; Dandachi, N.; Benvenuto, G.; Agostinis, F.; Sabbioni, S.; Berindan-Neagoe, I.; Romualdi, C.; Ardizzoni, A.; Trere, D.; Pichler, M.; D'Errico, A.; Ferracin, M.

10.1101/2021.02.03.429509 — pathology — Posted on 2021-02-03

3742 The biochemical resolving power of fluorescence lifetime imaging

Trinh, A. L.; Esposito, A.

10.1101/2021.02.03.429635 — biophysics — Posted on 2021-02-03

3743 Extending the Near Infrared Emission Range of Indium Phosphide Quantum Dots for Multiplexed In Vivo Imaging

Saeboe, A. M.; Nikiforov, A. Y.; Toufanian, R.; Kays, J. C.; Chern, M.; Han, K.; Casas, J. P.; Piryatinski, A.; Jones, D.; Dennis, A. M.

10.1101/2021.02.03.429632 — bioengineering — Posted on 2021-02-03

3744 Polar and non-polar fractions of deep fried edible oils induce differential cytotoxicity and hemolysis

Sneha, P.; Paul, Y.; Venugopal, M.; Narayanankutty, A.

10.1101/2021.02.03.429519 — biochemistry — Posted on 2021-02-03

3745 Does colour impact attention towards 2D images in geckos?

Katlein, N.; Ray, M.; Wilkinson, A.; Claude, J.; Kiskowski, M.; Wang, B.; Glaberman, S.; Chiari, Y.

10.1101/2021.02.03.429594 — animal behavior and cognition — Posted on 2021-02-03

3746 Using population-specific add-on polymorphisms to improve genotype imputation in underrepresented populations

Xu, Z. M.; Rüeger, S.; Zwyer, M.; Brites, D.; Hiza, H.; Reinhard, M.; Borrell, S.; Isihaka, F.; Temba, H.; Maroa, T.; Naftari, R.; Hella, J.; Sasamalo, M.; Reither, K.; Portevin, D.; Gagneux, S.; Fellay, J.

10.1101/2021.02.03.429542 — genetics — Posted on 2021-02-03

3747 Alien chromatin but not Fhb7 confers Fusarium head blight resistance in wheat breeding

Guo, X.; Shi, Q.; Yuan, J.; Wang, M.; Wang, J.; Wang, C.; Zhang, J.; Fu, S.; Su, H.; Liu, Y.; Wang, L.; Wang, K.; Jing, D.; Zhang, P.; Li, J.; Zhou, Y.; Ye, X.; Han, F.

10.1101/2021.02.03.429547 — genetics — Posted on 2021-02-03

3748 Rapid divergence in independent aspects of the compatibility phenotype in the Spiroplasma/Drosophila interaction.

Griffin, J. S.; Gerth, M.; Hurst, G. D. D.

10.1101/2021.02.03.429608 — evolutionary biology — Posted on 2021-02-03

3749 Bridging Between Material Properties Of Proteins And The Underlying Molecular Interactions

Song, G.

10.1101/2021.02.03.429521 — molecular biology — Posted on 2021-02-03

3750 A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion and virulence in the malaria parasite Plasmodium falciparum

MIAO, J.; Wang, C.; Lucky, A.; Liang, X.; Min, H.; Adapa, S. R.; Jiang, R.; Kim, K.; Cui, L.

10.1101/2021.02.03.429532 — microbiology — Posted on 2021-02-03

3751 The impact of genetic background and sex on the phenotype of IL-23 induced murine arthritis

Haley, E.; Matmusaev, M.; Hossain, I. N.; Davin, S.; Martin, T. M.; Ermann, J.

10.1101/2021.02.03.429523 — immunology — Posted on 2021-02-03

3752 The purine nucleoside phosphorylase pnp-1 regulates epithelial cell resistance to infection in C. elegans

Tecle, E.; Chhan, C. B.; Franklin, L.; Underwood, R. S.; Hanna-Rose, W.; Troemel, E. R.

10.1101/2021.02.03.429531 — immunology — Posted on 2021-02-03

3753 Selection of stimulus parameters for enhancing slow wave sleep events with a Neural-field theory thalamocortical computational model

Torres, F.; Orio, P.; Escobar, M.-J.

10.1101/2021.02.03.429528 — neuroscience — Posted on 2021-02-03

3754 'Nepotistic journals: a survey of biomedical journals.

Scanff, A.; Naudet, F.; Cristea, I.; Moher, D.; Bishop, D.; Locher, C.

10.1101/2021.02.03.429520 — scientific communication and education — Posted on 2021-02-03

3755 Sex Differences in Solute and Water Handling in the Human Kidney: Modeling and Functional Implications

Hu, R.; McDonough, A. A.; Layton, A.

10.1101/2021.02.03.429526 — physiology — Posted on 2021-02-03

3756 Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice

Weingartner, M.; Jebbawi, F.; Wang, J.; Stücheli, S.; Gottstein, B.; Beldi, G.; Lundström-Stadelmann, B.; Odermatt, A.

10.1101/2021.02.03.429530 — pathology — Posted on 2021-02-03

3757 SamQL: A Structured Query Language and filtering tool for the SAM/BAM file format

Lee, C. T.-Y.; Maragkakis, E.

10.1101/2021.02.03.429524 — bioinformatics — Posted on 2021-02-03

3758 Inferring time-lagged causality using the derivative of single-cell expression

Wei, H.-H.; Lu, H.; Zhao, H.

10.1101/2021.02.03.429525 — bioinformatics — Posted on 2021-02-03

3759 How public reaction to disease information across scales and the impacts of vector control methods influence disease prevalence and control efficacy

Jiao, J.; Suarez, G.; Fefferman, N.

10.1101/2021.02.03.429527 — ecology — Posted on 2021-02-03

3760 Genotyping Copy Number Alterations from single-cell RNA sequencing

Milite, S.; Bergamin, R.; Caravagna, G.

10.1101/2021.02.02.429335 — bioinformatics — Posted on 2021-02-03

3761 simplifyEnrichment: an R/Bioconductor package for Clustering and Visualizing Functional Enrichment Results

Gu, Z.; Huebschmann, D.

10.1101/2020.10.27.312116 — bioinformatics — Posted on 2021-02-03

3762 SWOTein: A structure-based approach to predict stability Strengths and Weaknesses of prOTEINs

Hou, Q.; Pucci, F.; Ancien, F.; Kwasigroch, J. M.; Bourgeas, R.; Rooman, M.

10.1101/2020.10.13.338046 — bioinformatics — Posted on 2021-02-03

3763 Nonlinear Stability Analysis for Artificial Kidney Multi-compartmental Models

Abohtyra, R.; Chait, Y.; Horowitz, J.

10.1101/2020.11.26.400606 — bioengineering — Posted on 2021-02-03

3764 Physiology and ecology together regulate host and vector importance for Ross River virus and other vector-borne diseases

Kain, M. P.; Skinner, E.; van den Hurk, A. F.; McCallum, H.; Mordecai, E. A.

10.1101/2021.01.28.428670 — ecology — Posted on 2021-02-03

3765 Evidence of Absence Regression: A Binomial N-Mixture Model for Estimating Fatalities at Wind Power Facilities

McDonald, T.; Bay, K.; Studyvin, J.; Leckband, J.; Schorg, A.; McIvor, J.

10.1101/2020.01.21.914754 — ecology — Posted on 2021-02-03

3766 Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma

Prummel, K. D.; Crowell, H. L.; Nieuwenhuize, S.; Brombacher, E. C.; Daetwyler, S.; Soneson, C.; Kresoja-Rakic, J.; Ronner, M.; Kocere, A.; Ernst, A.; Labbaf, Z.; Clouthier, D. E.; Firulli, A. B.; Sanchez-Iranzo, H.; Naganathan, S. R.; O'Rourke, R.; Raz, E.; Mercader, N.; Burger, A.; Felley-Bosco, E.; Huisken, J.; Robinson, M. D.; Mosimann, C.

10.1101/2020.11.11.355693 — developmental biology — Posted on 2021-02-03

3767 ADH5-mediated NO Bioactivity Maintains Metabolic Homeostasis in Brown Adipose Tissue

Sebag, S. C.; Zhang, Z.; Qian, Q.; Li, M.; Harata, M.; Li, W.; Zhu, Z.; Zingman, L.; Liu, L.; Lira, V. A.; Potthoff, M. J.; Bartelt, A.; Yang, L.

10.1101/2020.12.27.424489 — molecular biology — Posted on 2021-02-03

3768 Cell type classification and discovery across diseases, technologies and tissues reveals conserved gene signatures and enables standardized single-cell readouts

Chamberlain, M.; Hanamsagar, R.; Nestle, F. O.; de Rinaldis, E.; Savova, V.

10.1101/2021.02.01.429207 — immunology — Posted on 2021-02-02

3769 Cell type classification and discovery across diseases, technologies and tissues reveals conserved gene signatures and enables standardized single-cell readouts

Chamberlain, M.; Hanamsagar, R.; Nestle, F. O.; de Rinaldis, E.; Savova, V.

10.1101/2021.02.01.429207 — immunology — Posted on 2021-02-03

3770 Cerebral μ-opioid and CB1-receptor systems have distinct roles in human feeding behavior

Kantonen, T.; Karjalainen, T.; Pekkarinen, L.; Isojärvi, J.; Kalliokoski, K.; Kaasinen, V.; Hirvonen, J.; Nuutila, P.; Nummenmaa, L.

10.1101/2020.12.17.423284 — neuroscience — Posted on 2021-02-03

3771 Frontal cortical regions associated with attention connect more strongly to central than peripheral V1

Sims, S. A.; Demirayak, P.; Cedotal, S.; Visscher, K. M.

10.1101/2020.09.09.281725 — neuroscience — Posted on 2021-02-03

3772 Predicting modular functions and neural coding of behavior from a synaptic wiring diagram

Vishwanathan, A.; Ramirez, A.; Wu, J.; Sood, A.; Yang, R.; Kemnitz, N.; Ih, D.; Turner, N.; Lee, K.; Tartavull, I.; Silversmith, W. M.; Jordan, C. S.; David, C.; Bland, D.; Goldman, M. S.; Aksay, E.; Seung, H. S.

10.1101/2020.10.28.359620 — neuroscience — Posted on 2021-02-03

3773 A hardware/software system for electrophysiology "supersessions" in marmosets

Muthmann, J.-O.; Levi, A. J.; Carney, H. C.; Huk, A.

10.1101/2020.08.09.243279 — neuroscience — Posted on 2021-02-03

3774 Prolonged low-dose dioxin exposure impairs metabolic adaptability to high-fat diet feeding in female but not male mice

Matteo, G.; Hoyeck, M. P.; Blair, H. L.; Zebarth, J.; Rick, K. R.; Williams, A.; Gagne, R.; Buick, J. K.; Yauk, C.; Bruin, J. E.

10.1101/2020.09.12.294587 — pharmacology and toxicology — Posted on 2021-02-03

3775 Crystal structure determination of the armadillo repeat domain of Drosophila SARM1 using MIRAS phasing

Gu, W.; Luo, Z.; Vonrhein, C.; Jia, X.; Ve, T.; Nanson, J. D.; Kobe, B.

10.1101/2021.01.31.428505 — biophysics — Posted on 2021-02-03

3776 GranatumX: A community engaging, modularized and flexible software environment for single-cell analysis

Zhu, X.; Yunits, B.; Wolfgruber, T.; Liu, Y.; Huang, Q.; Poirion, O.; Arisdakessian, C.; Zhao, T.; Garmire, D.; Garmire, L.; Stanojevic, S.

10.1101/385591 — bioinformatics — Posted on 2021-02-03

3777 precisionFDA Truth Challenge V2: Calling variants from short- and long-reads in difficult-to-map regions

Olson, N. D.; Wagner, J.; McDaniel, J.; Stephens, S. H.; Westreich, S. T.; Prasanna, A. G.; Johanson, E.; Boja, E.; Maier, E. J.; Serang, O.; Jaspez, D.; Lorenzo-Salazar, J. M.; Munoz-Barrera, A.; Rubio-Rodriguez, L. A.; Flores, C.; Kyriakidis, K.; Malousi, A.; Shafin, K.; Pesout, T.; Jain, M.; Paten, B.; Chang, P.-C.; Kolesnikov, A.; Nattestad, M.; Baid, G.; Goel, S.; Yang, H.; Carroll, A.; Eveleigh, R.; Bourgey, M.; Bourque, G.; Li, G.; MA, C.; Tang, L.; DU, Y.; Zhang, S.; Morata, J.; Tonda, R.; Parra, G.; Trotta, J.-R.; Brueffer, C.; Demirkaya-Budak, S.; Kabakci-Zorlu, D.; Turgut, D.; Kalay

10.1101/2020.11.13.380741 — bioinformatics — Posted on 2021-02-03

3778 The regulatory landscape of Arabidopsis thaliana roots at single-cell resolution

Dorrity, M. W.; Alexandre, C.; Hamm, M.; Vigil, A.-L.; Fields, S.; Queitsch, C.; Cuperus, J.

10.1101/2020.07.17.204792 — genomics — Posted on 2021-02-03

3779 RNA-binding protein Syncrip regulates Starvation-Induced Hyperactivity in adult Drosophila

Chi, W.; Liu, W.; Fu, W.; Xia, S.; Heckscher, E. S.; Zhuang, X.

10.1101/2020.01.07.897652 — genomics — Posted on 2021-02-03

3780 Revisiting a GWAS peak in Arabidopsis thaliana reveals possible confounding by genetic heterogeneity

Sasaki, E.; Koecher, T.; Filiault, D.; Nordborg, M.

10.1101/2021.02.03.429533 — genetics — Posted on 2021-02-03

3781 Clinal and seasonal change are correlated in Drosophila melanogaster natural populations

Rodrigues, M. F.; Vibranovski, M. D.; Cogni, R.

10.1101/2020.03.19.999011 — evolutionary biology — Posted on 2021-02-03

3782 Disrupted Surfaces of Porous Membranes Reduce Nuclear YAP Localization through Diminished Cell Spreading and Enhance Adipogenesis

Allahyari, Z.; Casillo, S.; Perry, S.; Peredo, A. P.; Gholizadeh, S.; Gaborski, T. R.

10.1101/2021.01.31.429012 — cell biology — Posted on 2021-02-03

3783 Transcriptome and metabolome analysis of crGART, a novel cell model of de novo purine synthesis deficiency: Alterations in CD36 expression and activity

Mazzarino, R. C.; Baresova, V.; Zikanova, M.; Duval, N.; Wilkinson, T. G.; Patterson, D.; Vacano, G. N.

10.1101/2020.06.23.167924 — cell biology — Posted on 2021-02-03

3784 A validation scale to determine the readiness of environmental DNA assays for routine species monitoring

Thalinger, B.; Deiner, K.; Harper, L. R.; Rees, H. C.; Blackman, R. C.; Sint, D.; Traugott, M.; Goldberg, C. S.; Bruce, K.

10.1101/2020.04.27.063990 — molecular biology — Posted on 2021-02-03

3785 Glutamatergic dysfunction precedes neuron loss in cerebral organoids with MAPT mutation.

10.1101/2021.02.03.429623 — neuroscience — Posted on 2021-02-03

3786 Between-subject correlation of heart rate variability predicts movie preferences

So, T. Y.; Li, M. Y. E.; Lau, H.

10.1101/2020.10.12.335646 — neuroscience — Posted on 2021-02-03

3787 Exaggerated cytokine production in human peripheral blood mononuclear cells by recombinant SARS-CoV-2 spike glycoprotein S1 and its inhibition by dexamethasone

Olajide, O. A.; Iwuanyanwu, V. U.; Lepiarz-Raba, I.; Al-Hindawi, A. A.

10.1101/2021.02.03.429536 — pharmacology and toxicology — Posted on 2021-02-03

3788 Pre-mutagenic and mutagenic changes imprinted on the genomes of mammalian cells after irradiation with a nail polish dryer

Zhivagui, M.; Valenzuela, N.; Yeh, Y.-Y.; Dai, J.; He, Y.; Alexandrov, L. B.

10.1101/2021.02.03.429605 — cancer biology — Posted on 2021-02-03

3789 Discovery of a first-in-class inhibitor of the PRMT5-substrate adaptor interaction

McKinney, D. C.; McMillan, B. J.; Ranaghan, M.; Moroco, J. A.; Brousseau, M.; Mullin-Bernstein, Z.; O'Keefe, M.; McCarren, P.; Mesleh, M. F.; Mulvaney, K. M.; Singh, R.; Bajrami, B.; Skepner, A.; Timm, D. E.; Porter, D.; Kaushik, V.; Sellers, W. R.; Ianari, A.

10.1101/2021.02.03.429644 — cancer biology — Posted on 2021-02-03

3790 RNA polymerase II clusters form in line with liquid phase wetting of chromatin

Pancholi, A.; Klingberg, T.; Zhang, W.; Prizak, R.; Mamontova, I.; Noa, A.; Kobitski, A. Y.; Nienhaus, G. U.; Zaburdaev, V.; Hilbert, L.

10.1101/2021.02.03.429626 — biophysics — Posted on 2021-02-03

3791 Understanding of the 2-oxoglutarate dehydrogenase and 2-oxoadipate dehydrogenase assembly with the E2o core relevant to a hybrid complex formation

Zhang, X.; Jordan, F.; Nemeria, N. S.

10.1101/2021.02.03.429618 — biochemistry — Posted on 2021-02-03

3792 Nonsense-mediated decay is highly stable across individuals and tissues.

Teran, N. A.; Nachun, D.; Eulalio, T.; Ferraro, N. M.; Smail, C.; Rivas, M. A.; Montgomery, S. B.

10.1101/2021.02.03.429654 — genomics — Posted on 2021-02-03

3793 Variation in predicted COVID-19 risk among lemurs and lorises

Melin, A. D.; Orkin, J. D.; Janiak, M. C.; Valenzuela, A.; Kuderna, L. F.; Marrone, F.; Ramangason, H.; Horvath, J. E.; Roos, C.; Kitchener, A. C.; Khor, C. C.; Lim, W. K.; Lee, J. G.; Tan, P.; Umapathy, G.; Raveendran, M.; Harris, R. A.; Gut, I.; Gut, M.; Lizano, E.; Nadler, T.; Zinner, D.; Johnson, S. E.; Jarvis, E. D.; Fedrigo, O.; Wu, D.; Zhang, G.; Farh, K. K.-H.; Rogers, J.; Marques-Bonet, T.; Navarro, A.; Juan, D.; Arora, P. S.; Higham, J. P.

10.1101/2021.02.03.429540 — genetics — Posted on 2021-02-03

3794 Global spread and evolutionary history of HCV subtype 3a

Lin, S.-K.; De Maio, N.; Pedergnana, V.; Wu, C.-H.; Theze, J.; Barnes, E.; Ansari, A.

10.1101/2021.02.03.429581 — evolutionary biology — Posted on 2021-02-03

3795 Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development

Mead, T. J.; Martin, D. R.; Wang, L. W.; Cain, S. A.; Gulec, C.; Cahill, E.; Mauch, J.; Reinhardt, D. P.; Lo, C. W.; Baldock, C.; APTE, S.

10.1101/2021.02.03.429587 — developmental biology — Posted on 2021-02-03

3796 hC9ORF78 localizes to kinetochores and is required for proper chromosome segregation.

Koranne, R.; Brown, K.; Vandenbroek, H.; Taylor, W. R.

10.1101/2021.02.03.429653 — cell biology — Posted on 2021-02-03

3797 Oxidant-Resistant LRRC8A/C Anion Channels Support Superoxide Production by Nox1

Rohrbough, J.; Choi, H.; Nguyen, H.-N.; Dikalova, A.; Lamb, F. S.

10.1101/2021.02.03.429614 — cell biology — Posted on 2021-02-03

3798 MSX2 safeguards syncytiotrophoblast fate of human trophoblast stem cells

Hornbachner, R.; Lackner, A.; Haider, S.; Knöfler, M.; Mechtler, K.; Latos, P. A.

10.1101/2021.02.03.429538 — molecular biology — Posted on 2021-02-03

3799 The promiscuous and highly mobile resistome of a superbug.

Hernandez-Gonzalez, I.; Mateo-Estrada, V.; Castillo-Ramirez, S.

10.1101/2021.02.03.429652 — microbiology — Posted on 2021-02-03

3800 Individuals at risk for developing rheumatoid arthritis harbor differential intestinal bacteriophage communities with distinct metabolic potential

Mangalea, M. R.; Paez-Espino, D.; Kieft, K. A.; Chatterjee, A.; Seifert, J. A.; Feser, M. L.; Demoruelle, M. K.; Chriswell, M. E.; Sakatos, A.; Anantharaman, K.; Deane, K. D.; Kuhn, K. A.; Holers, V. M.; Duerkop, B. A.

10.1101/2021.02.03.429590 — microbiology — Posted on 2021-02-03

3801 Microbial population dynamics are dominated by stochastic forces in a low biomass subseafloor habitat

Anderson, R. E.; Graham, E. D.; Huber, J. A.; Tully, B. J.

10.1101/2021.02.03.429647 — microbiology — Posted on 2021-02-03

3802 Allogeneic CAR-invariant Natural Killer T Cells Exert Potent Antitumor Effects Through Host CD8 T cell Cross-Priming

Simonetta, F.; Lohmeyer, J. K.; Hirai, T.; Maas-Bauer, K.; Alvarez, M.; Wenokur, A. S.; Baker, J.; Aalipour, A.; Ji, X.; Haile, S.; Mackall, C. L.; Negrin, R. S.

10.1101/2021.02.03.428987 — immunology — Posted on 2021-02-03

3803 Fibroblast activation protein regulates natural killer cell migration, extravasation and tumor infiltration

Fitzgerald, A. A.; Marcisak, E. F.; Nasir, A.; Glasgow, E.; Jablonski, S.; Van der Veken, P.; Pearson, G.; Fertig, E. J.; Mace, E. M.; Weiner, L. M.

10.1101/2021.02.03.429622 — immunology — Posted on 2021-02-03

3804 Enabling multiscale variation analysis with genome graphs

Letcher, B.; Hunt, M.; Iqbal, Z.

10.1101/2021.02.03.429603 — bioinformatics — Posted on 2021-02-03

3805 Molecular dynamics simulation study of effects of key mutations in SARS-CoV-2 on protein structures

Lon, J. R.; Xi, B.; Zhong, B.; Zheng, Y.; Guo, P.; Chen, Z.; Du, H.

10.1101/2021.02.03.429495 — bioinformatics — Posted on 2021-02-03

3806 Characterization of the NiRAN domain from RNA-dependent RNA polymerase provides insights into a potential therapeutic target against SARS-CoV-2

Dwivedy, A.; Mariadasse, R.; Ahmad, M.; Chakraborty, S.; Kar, D.; Tiwari, S.; Majumdar, T.; Jeyakanthan, J.; Biswal, B.

10.1101/2021.02.03.429510 — bioinformatics — Posted on 2021-02-03

3807 A high-throughput radioactivity-based assay for screening SARS-CoV-2 nsp10-nsp16 complex

Khalili Yazdi, A.; Li, F.; Devkota, K.; Perveen, S.; Ghiabi, P.; Hajian, T.; Bolotokova, A.; Vedadi, M.

10.1101/2021.02.03.429625 — biochemistry — Posted on 2021-02-03

3808 Who infects Whom? - Reconstructing infection chains of Mycobacterium avium ssp. paratuberculosis in an endemically infected dairy herd by use of genomic data

Nigsch, A.; Robbe-Austerman, S.; Stuber, T. P.; Pavinski Bitar, P. D.; Grohn, Y. D.; Schukken, Y. H.

10.1101/2021.02.03.429502 — genomics — Posted on 2021-02-03

3809 Unfazed: parent-of-origin detection for large and small de novo variants

Belyeu, J. R.; Sasani, T. A.; Pedersen, B. S.; Quinlan, A. R.

10.1101/2021.02.03.429658 — genomics — Posted on 2021-02-03

3810 Summix: A method for detecting and adjusting for population structure in genetic summary data

Arriaga-MacKenzie, I. S.; Matesi, G.; Chen, S.; Ronco, A.; Marker, K. M.; Hall, J. R.; Scherenberg, R.; Khajeh-Sharafabadi, M.; Wu, Y.; Gignoux, C. R.; Null, M.; Hendricks, A. E.

10.1101/2021.02.03.429446 — genetics — Posted on 2021-02-03

3811 Why do species get a thin slice of π? Revisiting Lewontin's Paradox of Variation

Buffalo, V.

10.1101/2021.02.03.429633 — evolutionary biology — Posted on 2021-02-03

3812 Multi-specific DARPin(R) therapeutics demonstrate very high potency against mutated SARS-CoV-2 variants in vitro

Rothenberger, S.; Walser, M.; Malvezzi, F.; Mayor, J.; Ryter, S.; Moreno, H.; Liechti, N.; Halg, S.; Bosshart, A.; Iss, C.; Calabro, V.; Cornelius, A.; Hospodarsch, T.; Neculcea, A.; Looser, T.; Mangold, S.; Reichen, C.; Radom, F.; Dawson, K. M.; Lewis, S.; Steiner, D.; Amstutz, P.; Engler, O.; Stumpp, M. T.

10.1101/2021.02.03.429164 — immunology — Posted on 2021-02-03

3813 Impact of the B.1.1.7 variant on neutralizing monoclonal antibodies recognizing diverse epitopes on SARS-CoV-2 Spike

Graham, C.; Seow, J.; Huettner, I.; Khan, H.; Kouphou, N.; Acors, S.; Winstone, H.; Pickering, S.; Pedro Galao, R.; Jose Lista, M.; Jimenez-Guardeno, J. M.; Laing, A. G.; Wu, Y.; Joseph, M.; Muir, L.; Ng, W. M.; Duyvesteyn, H. M. E.; Zhao, Y.; Bowden, T. A.; Shankar-Hari, M.; Rosa, A.; Cherepanov, P.; McCoy, L. E.; Hayday, A. C.; Neil, S. J. D.; Malim, M. H.; Doores, K. J.

10.1101/2021.02.03.429355 — immunology — Posted on 2021-02-03

3814 Pelagic larval polyclads that practice macrophagous carnivory

von Dassow, G.; Mendes, C. B.

10.1101/2021.02.03.429620 — zoology — Posted on 2021-02-03

3815 Light spectra trigger divergent gene expression in barley cultivars

Monteagudo, A.; Rodriguez del Rio, A.; Contreras-Moreira, B.; Kiss, T.; Mayer, M.; Karsai, I.; Igartua, E.; Casas, A. M.

10.1101/2021.02.03.429565 — plant biology — Posted on 2021-02-03

3816 A semi-empirical model of the aerodynamics of manoeuvring insect flight

Taylor, G. K.; Walker, S. M.

10.1101/2020.01.09.900654 — biophysics — Posted on 2021-02-03

3817 Evolution is in the details: Regulatory differences in modern human and Neanderthal

Barker, H.; Parkkila, S.; Tolvanen, M.

10.1101/2020.09.04.282749 — genomics — Posted on 2021-02-03

3818 'Phytopathological strolls' in the dual context of COVID-19 lockdown and IYPH2020: transforming constraints into an opportunity for public education about plant pathogens

Suffert, F.; Suffert, M.

10.1101/2021.02.03.429201 — microbiology — Posted on 2021-02-03

3819 Establishment of Multi-stage Intravenous Self-administration in Mice

Slosky, L. M.; Pires, A.; Bai, Y.; Clark, N.; Hauser, E. R.; Gross, J. D.; Porkka, F.; Zhou, Y.; Chen, X.; Pogorelov, V. M.; Toth, K.; Wetsel, W. C.; Barak, L. S.; Caron, M. G.

10.1101/2020.11.25.398503 — neuroscience — Posted on 2021-02-03

3820 Antibiotic tolerance, persistence, and resistance of the evolved minimal cell, Mycoplasma mycoides JCVI-Syn3B.

Hossain, T.; Deter, H. S.; Peters, E. J.; Butzin, N. C.

10.1101/2020.06.02.130641 — synthetic biology — Posted on 2021-02-03

3821 Systematic monitoring of photosynthetically-derived oxidative signals using a 2-Cys peroxiredoxin-based redox probe

Lampl, N.; Nissan, I.; Gilad, G.; Hipsch, M.; Rosenwasser, S.

10.1101/2021.02.03.429619 — plant biology — Posted on 2021-02-03

3822 Autoregulation dependent and independent mechanisms are responsible for the systemic control of nodule formation by the plant N demand

Pervent, M.; Lambert, I.; Tauzin, M.; Kairouani, A.; Nigg, M.; Jardinaud, M.-F.; Severac, D.; Colella, S.; Martin-Magniette, M.-L.; Lepetit, M.

10.1101/2021.02.03.429583 — plant biology — Posted on 2021-02-03

3823 Touch-triggered bZIP translocation regulates elongation and secondary wall biosynthesis

Coomey, J. H.; MacKinnon, K. J.-M.; Handakumbura, P.; McCahill, I. W.; Trabucco, G. M.; Mazzola, J.; Leblanc, N. A.; Kheam, R.; Hernandez-Romero, M.; Barry, K. W.; Liu, L.; Lee, J. E.; Vogel, J. P.; O'Malley, R.; Chambers, J. J.; Hazen, S. P.

10.1101/2021.02.03.429573 — plant biology — Posted on 2021-02-03

3824 Multiple indole glucosinolates and myrosinases defend Arabidopsis against Tetranychus urticae herbivory

Widemann, E.; Bruinsma, K.; Walshe-Roussel, B.; Saha, R. K.; Letwin, D.; Zhurov, V.; Bernards, M. A.; Grbic, M.; Grbic, V.

10.1101/2021.02.03.429630 — plant biology — Posted on 2021-02-03

3825 The record of Deinotheriidae from the Miocene of the Swiss Jura Mountains (Jura Canton, Switzerland)

Gagliardi, F.; Maridet, O.; Becker, D.

10.1101/2020.08.10.244061 — paleontology — Posted on 2021-02-03

3826 Structure of plant PSI-plastocyanin complex reveals strong hydrophobic interactions.

Caspy, I.; Fadeeva, M.; Kuhlgert, S.; Borovikova-Sheinker, A.; Klaiman, D.; Masrati, G.; Drepper, F.; Ben-Tal, N.; Hippler, M.; Nelson, N.

10.1101/2021.02.03.429574 — biochemistry — Posted on 2021-02-03

3827 Viral susceptibility across host species is largely independent of dietary protein to carbohydrate ratios

Roberts, K. E.; Longdon, B.

10.1101/2020.10.21.348987 — evolutionary biology — Posted on 2021-02-03

3828 Potential global impact of the N501Y mutation on MHC-II presentation and immune escape

Castro, A.; Carter, H.; Zanetti, M.

10.1101/2021.02.02.429431 — bioinformatics — Posted on 2021-02-03

3829 Functional Organization of the Maternal and Paternal Human 4D Nucleome

Lindsly, S. M.; Jia, W.; Chen, H.; Liu, S.; Ronquist, S.; Chen, C.; Wen, X.; Dotson, G.; Ryan, C.; Omenn, G. S.; Li, S. C.; Wicha, M.; Rehemtulla, A.; Muir, L.; Rajapakse, I.

10.1101/2020.03.15.992164 — genomics — Posted on 2021-02-03

3830 Visualizing cellular and tissue ultrastructure using Ten-fold Robust Expansion Microscopy (TREx)

Damstra, H. G. J.; Mohar, B.; Eddison, M.; Akhmanova, A.; Kapitein, L. C.; Tillberg, P. W.

10.1101/2021.02.03.428837 — cell biology — Posted on 2021-02-03

3831 Identification of a Nervous System Gene Expression Signature in Colon Cancer Stem Cells Reveals a Role for Neural Crest Regulators EGR2 and SOX2 in Tumorigenesis

Regan, J. L.; Schumacher, D.; Staudte, S.; Steffen, A.; Lesche, R.; Toedling, J.; Jourdan, T.; Haybaeck, J.; Golob-Schwarzl, N.; Mumberg, D.; Henderson, D.; Gyorffy, B.; Regenbrecht, C. R. A.; Keilholz, U.; Schafer, R.; Lange, M.

10.1101/2021.02.02.428317 — cell biology — Posted on 2021-02-03

3832 Full Brain and Lung Prophylaxis against SARS-CoV-2 by Intranasal Lentiviral Vaccination in a New hACE2 Transgenic Mouse Model or Golden Hamsters

Ku, M.-W.; Authie, P.; Bourgine, M.; Anna, F.; Noirat, A.; Moncoq, F.; Vesin, B.; Nevo, F.; Lopez, J.; Souque, P.; Blanc, C.; Chardenoux, S.; Lafosse, I.; Hardy, D.; Nemirov, K.; Guinet, F.; Langa Vives, F.; Majlessi, L.; Charneau, P.

10.1101/2021.02.03.429211 — microbiology — Posted on 2021-02-03

3833 Identification of the SHREK family of proteins as broad-spectrum host antiviral factors

Dabbagh, D.; He, S.; Hetrick, B.; Chilin, L.; Andalibi, A.; Wu, Y.

10.1101/2021.02.02.429469 — microbiology — Posted on 2021-02-03

3834 Assessment of immunogenicity and protective efficacy of ZyCoV-D DNA vaccine candidates in Rhesus macaques against SARS-CoV-2 infection

Yadav, P.; Kumar, S.; Agarwal, K.; Jain, M.; Patil, D.; Maithal, K.; Mathapati, B.; Giri, S.; Mohandas, S.; Shete, A.; Sapkal, G.; Patil, D.; Dey, A.; Chandra, H.; Deshpande, G.; Gupta, N.; Nyayanit, D.; Kaushal, H.; Sahay, R.; Tripathy, A.; Jain, R.; Kumar, A.; Sarkale, P.; Baradkar, S.; Rajanathan, C.; Raju, H. P.; Patel, S.; Shah, N.; Dwivedi, P.; Singh, D.; Abraham, P.

10.1101/2021.02.02.429480 — microbiology — Posted on 2021-02-03

3835 In silico, in vitro and in cellulo models for monitoring SARS-CoV-2 spike/human ACE2 complex, viral entry and cell fusion

Lapaillerie, D.; Chariler, C.; Fernandes, H. S.; Sousa, S.; Lesbats, P.; Weigel, P.; Favereaux, A.; Guyonnnet-Duperat, V.; Parissi, V.

10.1101/2021.02.03.429555 — microbiology — Posted on 2021-02-03

3836 Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection

Pekayvaz, K.; Leunig, A.; Kaiser, R.; Brambs, S.; Joppich, M.; Janjic, A.; Popp, O.; Polewka, V.; Wange, L. E.; Gold, C.; Kirchner, M.; Muenchhoff, M.; Hellmuth, J. C.; Scherer, C.; Eser, T.; Deak, F.; Kuhl, N.; Linder, A.; Saar, K.; Tomas, L.; Schulz, C.; Enard, W.; Kroidl, I.; Geldmacher, C.; von Bergwelt-Baildon, M.; Keppler, O. T.; Zimmer, R.; Mertins, P.; Huebner, N.; Hoelscher, M.; Massberg, S.; Stark, K.; Nicolai, L.

10.1101/2021.02.03.429351 — immunology — Posted on 2021-02-03

3837 Potent in vitro Neutralization of SARS-CoV-2 by Hetero-bivalent Alpaca Nanobodies Targeting the Spike Receptor-Binding Domain

Ma, H.; Zeng, W.; Meng, X.; Huang, X.; Yang, Y.; Zhao, D.; Zhou, P.; Wang, X.; Zhao, C.; Sun, Y.; Wang, P.; Ou, H.; Hu, X.; Xiang, Y.; Jin, T.

10.1101/2021.02.02.429311 — immunology — Posted on 2021-02-03

3838 Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia

Garcia-Bermudez, J.; Prasad, S.; Baudrier, L.; Badgley, M. A.; Liu, Y.; La, K.; Soula, M.; Williams, R. T.; Yamaguchi, N.; Hwang, R. F.; Taylor, L. J.; De Stanchina, E.; Rostandy, B.; Alwaseem, H.; Molina, H.; Bar-Sagi, D.; Birsoy, K.

10.1101/2021.02.02.429407 — cancer biology — Posted on 2021-02-03

3839 Revision of commonly accepted Warburg mechanism of cancer development. Redox-sensitive mitochondrial cytochromes in breast and brain cancers by Raman imaging

Abramczyk, H.; Surmacki, J.; Brozek-Pluska, B.; Kopec, M.

10.1101/2021.02.03.429508 — cancer biology — Posted on 2021-02-03

3840 CovRadar: Continuously tracking and filtering SARS-CoV-2 mutations for molecular surveillance

Wittig, A.; Miranda, F.; Tang, M.; Hölzer, M.; Renard, B. Y.; Fuchs, S.

10.1101/2021.02.03.429146 — bioinformatics — Posted on 2021-02-03

3841 Bacterial expression and purification of functional recombinant SARS-CoV-2 spike receptor binding domain

Prahlad, J.; Struble, L.; Lutz, W. E.; Wallin, S. A.; Khurana, S.; Schnaubelt, A.; Broadhurst, M. J.; Bayles, K.; Borgstahl, G. E. O.

10.1101/2021.02.03.429601 — biochemistry — Posted on 2021-02-03

3842 Discovery of re-purposed drugs that slow SARS-CoV-2 replication in human cells

Pickard, A.; Calverley, B. C.; Chang, J.; Garva, R.; Lu, Y.; Kadler, K. E.

10.1101/2021.01.31.428851 — immunology — Posted on 2021-02-03

3843 LIFE AND WORK OF RESEARCHERS TRAPPED IN THE COVID-19PANDEMIC VICIOUS CYCLE

Ghaffarizadeh, S. A.; Ghaffarizadeh, S. A.; Behbahani, A. H.; Mehdizadeh, M.; Olechowski, A.

10.1101/2021.02.02.429476 — scientific communication and education — Posted on 2021-02-03

3844 The flavin monooxygenase Bs3 triggers cell death in plants, impairs growth in yeast and produces H2O2 in vitro

Kroenauer, C.; Lahaye, T.

10.1101/2021.02.03.429511 — plant biology — Posted on 2021-02-03

3845 Improved alpha-beta power reduction via combined Electrical and Ultrasonic stimulation in a Parkinsonian Cortex-Basal Ganglia-Thalamus Computational Model

Tarnaud, T.; Joseph, W.; Schoeters, R.; Martens, L.; Tanghe, E.

10.1101/2021.02.03.429377 — neuroscience — Posted on 2021-02-03

3846 Multiscale three-dimensional imaging of intact human organs down to the cellular scale using hierarchical phase-contrast tomography

Walsh, C.; Tafforeau, P.; Wagner, W. L.; Jafree, D. J.; Bellier, A.; Werlein, C.; Kühnel, M. P.; Boller, E.; Walker-Samuel, S.; Robertus, J. L.; Long, D. A.; Jacob, J.; Marussi, S.; Brown, E. E.; Holroyd, N.; Jonigk, D. D.; Ackermann, M.; Lee, P. D.

10.1101/2021.02.03.429481 — physiology — Posted on 2021-02-03

3847 Diffusion of the disordered E-cadherin tail on β-catenin

Wiggers, F.; Wohl, S.; Dubovetskyi, A.; Rosenblum, G.; Zheng, W.; Hofmann, H.

10.1101/2021.02.03.429507 — biophysics — Posted on 2021-02-03

3848 Co-linear chaining with overlaps and gap costs

Jain, C.; Gibney, D.; Thankachan, S. V.

10.1101/2021.02.03.429492 — bioinformatics — Posted on 2021-02-03

3849 DeepDRIM: a deep neural network to reconstruct cell-type-specific gene regulatory network using single-cell RNA-seq data

Chen, J.; Cheong, C.; Lan, L.; Zhou, X.; Liu, J.; Lu, A.; Cheung, W. K.; Zhang, L.

10.1101/2021.02.03.429484 — bioinformatics — Posted on 2021-02-03

3850 APICURON: a database to credit and acknowledge the work of biocurators

Hatos, A.; Quaglia, F.; Piovesan, D.; Tosatto, S. C. E.

10.1101/2021.02.03.429425 — bioinformatics — Posted on 2021-02-03

3851 Mutational effects of ubiquitously present gamma radiation on Arabidopsis thaliana: insight into radiosensitivity in the reproductive stage

Hirao, A. S.; Watanabe, Y.; Hasegawa, Y.; Takagi, T.; Ueno, S.; Kaneko, S.

10.1101/2021.02.03.429546 — genetics — Posted on 2021-02-03

3852 Large portion of essential genes is missed by screening either fly or beetle indicating unexpected diversity of insect gene function

Hakeemi, M. S.; Ansari, S.; Teuscher, M.; Weisskopf, M.; Grossmann, D.; Kessel, T.; Dönitz, J.; Siemanowski, J.; Wan, X.; Schultheis, D.; Frasch, M.; Roth, S.; Schoppmeier, M.; Klingler, M.; Bucher, G.

10.1101/2021.02.03.429118 — genetics — Posted on 2021-02-03

3853 Energy-harnessing problem solving of primordial life: modeling the emergence of catalytic host-parasite life cycles

Conrad, B.; Pirovino, M.

10.1101/2021.02.03.429491 — evolutionary biology — Posted on 2021-02-03

3854 Frequent coexistence of closely related tree species on a small scale in temperate evergreen forests in Japan

Watanabe, S.; Maesako, Y.

10.1101/2021.02.03.429543 — ecology — Posted on 2021-02-03

3855 A biomechanical switch regulates the transition towards homeostasis in esophageal epithelium

McGinn, J.; Hallou, A.; Han, S.; Krizic, K.; Ulyanchenko, S.; Iglesias-Bartolome, R.; England, F. J.; Verstreken, C.; Chalut, K. J.; Jensen, K. B.; Simons, B. D.; Alcolea, M. P.

10.1101/2021.02.03.428820 — cell biology — Posted on 2021-02-03

3856 A programmable pAgo nuclease with universal guide and target specificity from the mesophilic bacterium Kurthia massiliensis

Kropocheva, E.; Kuzmenko, A.; Aravin, A.; Esyunina, D.; Kulbachiskiy, A.

10.1101/2021.02.03.429301 — molecular biology — Posted on 2021-02-03

3857 Pathogenic bacteria grown in iron and zinc milieu exhibit magnetotaxis

Ghosh, D.; Kaushik, S.; Thomas, J.; Panwar, V.; Murugesan, P.; Singh, R.; Roy, H. S.; Kumar, R.; Chopra, V.; Gautam, V.

10.1101/2021.02.03.429514 — microbiology — Posted on 2021-02-03

3858 In vivo antigen expression regulates CD4 T cell differentiation and vaccine efficacy against Mycobacterium tuberculosis infection

Strand Clemmensen, H.; Dube, J.-Y.; McIntosh, F.; Rosenkrands, I.; Jungersen, G.; Aagaard, C.; Andersen, P.; Behr, M. A.; Mortensen, R.

10.1101/2021.02.02.429488 — immunology — Posted on 2021-02-03

3859 Structural variability and concerted motions of the T cell receptor - CD3 complex

Pandey, P. R.; Rozycki, B.; Lipowsky, R.; Weikl, T. R.

10.1101/2021.02.03.429549 — immunology — Posted on 2021-02-03

3860 MTHFD2 is a Metabolic Checkpoint Controlling Effector and Regulatory T Cell Fate and Function

Sugiura, A.; Andrejeva, G.; Voss, K.; Heintzman, D. R.; Beier, K. L.; Wolf, M. M.; Greenwood, D. L.; Ye, X.; Shahi, S. K.; Freedman, S. N.; Cameron, A. M.; Foerch, P.; Bourne, T.; Xu, X.; Garcia-Canaveras, J. C.; Mangalam, A. K.; Rabinowitz, J.; Rathmell, J.

10.1101/2021.02.03.428939 — immunology — Posted on 2021-02-03

3861 Down Regulation Of IL-1β Secretion By TGF-β1 In Macrophages Infected With Dengue Virus

Ramirez-Aguero, B.; Serrato-Salas, J.; Montiel Hernandez, J. L.; Gonzalez-Christen, J.

10.1101/2021.02.03.429556 — immunology — Posted on 2021-02-03

3862 Mechanoreceptor synapses in the brainstem shape the central representation of touch

Lehnert, B. P.; Santiago, C.; Huey, E. L.; Emanuel, A. J.; Renauld, S.; Africawala, N.; Alkislar, I.; Zheng, Y.; Bai, L.; Koutsioumpa, C.; Hong, J. T.; Magee, A. R.; Harvey, C. D.; Ginty, D. D.

10.1101/2021.02.02.429463 — neuroscience — Posted on 2021-02-03

3863 Compensatory variability in network parameters enhances memory performance in the Drosophila mushroom body

Abdelrahman, N. Y.; Vasilaki, E.; Lin, A. C.

10.1101/2021.02.03.429444 — neuroscience — Posted on 2021-02-03

3864 Central inhibition of P2Y12R differentially regulates survival and neuronal loss in MPTP-induced Parkinsonism in mice

Iring, A.; Toth, A.; Baranyi, M.; Otrokocsi, L.; Modis, L. V.; Goloncser, F.; Varga, B.; Hortobagyi, T.; Bereczki, D.; Denes, A.; Sperlagh, B.

10.1101/2021.02.03.256941 — neuroscience — Posted on 2021-02-03

3865 Brain2Pix: Fully convolutional naturalistic video reconstruction from brain activity

Le, L.; Ambrogioni, L.; Seeliger, K.; Güclütürk, Y.; van Gerven, M.; Güclü, U.

10.1101/2021.02.02.429430 — neuroscience — Posted on 2021-02-03

3866 Effects of awareness and task relevance on neurocomputational models of mismatch negativity generation

Schlossmacher, I.; Lucka, F.; Bruchmann, M.; Straube, T.

10.1101/2021.02.03.429421 — neuroscience — Posted on 2021-02-03

3867 Hoplonemertean larvae are planktonic predators that capture and devour active animal prey

von Dassow, G.; Mendes, C. B.; Robbins, K.; Andrade, S. C. S.; Maslakova, S. A.

10.1101/2021.02.02.429399 — zoology — Posted on 2021-02-03

3868 High Throughput Fitness Profiling Reveals Loss Of GacS-GacA Regulation Improves Indigoidine Production In Pseudomonas putida

Eng, T. T.; Banerjee, D.; Lau, A. K.; Bowden, E.; Herbert, R. A.; Trinh, J.; Prahl, J.-P.; Deutschbauer, A.; Tanjore, D.; Mukhopadhyay, A.

10.1101/2021.02.02.429437 — systems biology — Posted on 2021-02-03

3869 The effect of mentee and mentor gender on scientific productivity of applicants for NIH training fellowships

Yu, H.; Willis, K. A.; Litovitz, A.; Harriman, R. M.; Davis, M. T.; Meyer, P.; Busse, B.; Meseroll, R. A.; Wijayatilake, H. D.; Perkins, M. J.; Anderson, J. M.; Santangelo, G. M.

10.1101/2021.02.02.429450 — scientific communication and education — Posted on 2021-02-03

3870 Dynamic histone acetylation in floral volatile synthesis and emission in petunia flowers

Patrick, R. M.; Huang, X.-Q.; Dudareva, N.; Li, Y.

10.1101/2021.02.02.429379 — plant biology — Posted on 2021-02-03

3871 A development guide for evaluating the maximum yield potential stage in barley

Thirulogachandar, V.; Schnurbusch, T.

10.1101/2021.02.02.429383 — plant biology — Posted on 2021-02-03

3872 Comparison of starch granule sizes of maize seeds between parental lines and derived hybrids

Niu, L.; Wang, W.

10.1101/2021.02.03.429493 — plant biology — Posted on 2021-02-03

3873 Redefining tumor classification and clinical stratification through a colorectal cancer single-cell atlas

10.1101/2021.02.02.429256 — cancer biology — Posted on 2021-02-03

3874 Voltage-Gated Potassium Channel Kv1.3 as a Therapeutic Target for Pancreatic Ductal Adenocarcinoma

Li, W.; Wilson, G.; Bachmann, M.; Wang, J.; Mattarei, A.; Paradisi, C.; Edwards, M.; Szabo, I.; Gulbins, E.; Ahmad, S.; Patel, S.

10.1101/2021.02.03.429505 — cancer biology — Posted on 2021-02-03

3875 Three-dimensional interactions between integrated HPV genomes and cellular chromatin dysregulate host gene expression in early cervical carcinogenesis

Groves, I. J.; Drane, E. L.; Michalski, M.; Monahan, J. M.; Scarpini, C. G.; Smith, S. P.; Bussotti, G.; Varnai, C.; Schoenfelder, S.; Fraser, P.; Enright, A. J.; Coleman, N.

10.1101/2021.02.03.429496 — cancer biology — Posted on 2021-02-03

3876 SpatialDWLS: accurate deconvolution of spatial transcriptomic data

Dong, R.; Yuan, G.-C.

10.1101/2021.02.02.429429 — bioinformatics — Posted on 2021-02-03

3877 Sorghum pan-genome explores the functional utility to accelerate the genetic gain

Ruperao, P.; Thirunavukkarasu, N.; Gandham, P.; Selvanayagam, S.; M, G.; Nebie, B.; Manyasa, E.; Gupta, R.; Gandhi, H.; Das, R. R.; Edwards, D.; Deshpande, S.; Rathore, A.

10.1101/2021.02.02.429137 — bioinformatics — Posted on 2021-02-03

3878 Improving deep learning-based protein distance prediction in CASP14

Guo, Z.; Wu, T.; Liu, J.; Hou, J.; Cheng, J.

10.1101/2021.02.02.429462 — bioinformatics — Posted on 2021-02-03

3879 Effect of air pockets in drug delivery in jet injections

Rohilla, P.; Khusnatdinov, E.; Marston, J. O.

10.1101/2021.02.02.429451 — bioengineering — Posted on 2021-02-03

3880 Enzyme kinetics of CRISPR molecular diagnostics

Ramachandran, A.; Santiago, J. G.

10.1101/2021.02.03.429513 — bioengineering — Posted on 2021-02-03

3881 Lateral Undulation Aids Biological and Robotic Earthworm Anchoring and Locomotion

Ozkan-Aydin, Y.; Liu, B.; Carruthers Ferrero, A.; Seidel, M.; Hammond, F. L.; Goldman, D. I.

10.1101/2021.02.02.429151 — animal behavior and cognition — Posted on 2021-02-03

3882 Specialization and selective social attention establishes the balance between individual and social learning

Wu, C. M.; Ho, M.; Kahl, B.; Leuker, C.; Meder, B.; Kurvers, R.

10.1101/2021.02.03.429553 — animal behavior and cognition — Posted on 2021-02-03

3883 Chimpanzees use numerous flexible vocal sequences with more than two vocal units: A step towards language?

Girard-Buttoz, C.; Zaccarella, E.; Bortolato, T.; Friederici, A. D.; Wittig, R. M.; Crockford, C.

10.1101/2021.02.03.429517 — animal behavior and cognition — Posted on 2021-02-03

3884 Characterization of Poldip2 knockout mice: avoiding incorrect gene targeting

Lassegue, B.; Kumar, S.; Mandavilli, R.; Wang, K.; Tzai, M.; Kang, D.-W.; Hernandes, M. S.; San Martin, A.; Jo, H.; Taylor, W. R.; Griendling, K. K.

10.1101/2021.02.02.429447 — genetics — Posted on 2021-02-03

3885 Autophagy as a mechanism for adaptive prediction-mediated emergence of drug resistance

Nivedita, N.; Aitchison, J. D.; Baliga, N. S.

10.1101/2021.02.02.429461 — evolutionary biology — Posted on 2021-02-03

3886 Advancing admixture graph estimation via maximum likelihood network orientation

Molloy, E. K.; Durvasula, A.; Sankararaman, S.

10.1101/2021.02.02.429467 — evolutionary biology — Posted on 2021-02-03

3887 Evolutionary modelling of HCV subtypes provides rationale for their different disease outcomes

Zhang, H.; Quadeer, A. A.; McKay, M. R.

10.1101/2021.02.02.429470 — evolutionary biology — Posted on 2021-02-03

3888 Integration of APSIM and PROSAIL models to develop more precise radiometric estimation of crop traits using deep learning

Chen, Q.; Zheng, B.; Chen, T.; Chapman, S.

10.1101/2021.02.02.429471 — ecology — Posted on 2021-02-03

3889 Transmission of pre-XDR and XDR-TB in the Mumbai Metropolitan Region, India

Dreyer, V.; Mandal, A.; Dev, P.; Merker, M.; Barilar, I.; Utpatel, C.; Nilgiriwala, K.; Rodrigues, C.; Crook, D. W.; CRyPTIC Consortium, ; Mistry, N. S.; Niemann, S.

10.1101/2021.02.02.429364 — molecular biology — Posted on 2021-02-03

3890 Year-round dynamics of amplicon sequence variant communities differ among eukaryotes, Mimiviridae, and prokaryotes in a coastal ecosystem

Prodinger, F.; Endo, H.; Takano, Y.; Li, Y.; Tominaga, K.; Isozaki, T.; Blanc-Mathieu, R.; Gotoh, Y.; Tetsuya, H.; Taniguchi, E.; Nagasaki, K.; Yoshida, T.; Ogata, H.

10.1101/2021.02.02.429489 — microbiology — Posted on 2021-02-03

3891 Defining a Connectome-Based Predictive Model of Attentional Control in Aging

Fountain-Zaragoza, S.; Manglani, H. R.; Rosenberg, M. D.; Andridge, R.; Prakash, R. S.

10.1101/2021.02.02.429232 — neuroscience — Posted on 2021-02-03

3892 A model of the appearance of the moving human eye

Aguirre, G. K.

10.1101/2021.02.02.429411 — neuroscience — Posted on 2021-02-03

3893 Marker-free imaging of α-Synuclein aggregates in a rat model of Parkinson' disease using Raman microspectroscopy

Sevgi, F.; Brauchle, E. M.; Carvajal-Berrio, D. A.; Schenke-Layland, K.; Casadei, N.; Salker, M.; Riess, O.; Singh, Y.

10.1101/2021.02.02.429468 — neuroscience — Posted on 2021-02-03

3894 Extracellular membrane tubules involved in suberin deposition in plant cell walls

De Bellis, D.; Kalmbach, L.; Marhavy, P.; Daraspe, J.; Geldner, N.; Barberon, M.

10.1101/2021.02.02.429332 — plant biology — Posted on 2021-02-03

3895 Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia

Birsoy, K.; Bar-Sagi, D.; Garcia-Bermudez, J.; Prasad, S.; Baudrier, L.; Badgley, M. A.; Liu, Y.; La, K.; Soula, M.; Williams, R. T.; Yamaguchi, N.; Hwang, R. F.; Taylor, L. J.; De Stanchina, E.; Rostandy, B.; Alwaseem, H.; Molina, H.

10.1101/2021.02.02.429407 — cancer biology — Posted on 2021-02-03

3896 MicroPIPE: An end-to-end solution for high-quality complete bacterial genome construction

Murigneux, V.; Roberts, L.; Forde, B. M.; Phan, M.-D.; Nguyen, T. K. N.; Irwin, A. D.; Harris, P. N. A.; Paterson, D. L.; Schembri, M. A.; Whiley, D. M.; Beatson, S. A.

10.1101/2021.02.02.429319 — bioinformatics — Posted on 2021-02-03

3897 A variant selection framework for genome graphs

Jain, C.; Tavakoli, N.; Aluru, S.

10.1101/2021.02.02.429378 — bioinformatics — Posted on 2021-02-03

3898 Genotyping Copy Number Alterations from single-cell RNA sequencing

Milite, S.; Bergamin, R.; Caravagna, G.

10.1101/2021.02.02.429335 — bioinformatics — Posted on 2021-02-03

3899 Quantifying the severity of adverse drug reactions using social media

Lavertu, A.; Hamamsy, T.; Altman, R. B.

10.1101/2021.02.02.429445 — bioinformatics — Posted on 2021-02-03

3900 Privacy-Preserving Genotype Imputation in a Trusted Execution Environment

Dokmai, N.; Kockan, C.; Zhu, K.; Wang, X.; Sahinalp, S. C.; Cho, H.

10.1101/2021.02.02.429428 — bioinformatics — Posted on 2021-02-03

3901 Drug delivery via tattooing: Effect of needle and fluid properties

Lawal, I.; Rohilla, P.; Marston, J.

10.1101/2021.02.02.429454 — bioengineering — Posted on 2021-02-03

3902 INCORPORATING A DYNAMIC GENE-BASED PROCESS MODULE INTO A CROP SIMULATION MODEL

Oliveira, F. A. A.; Jones, J. W.; Pavan, W.; Bhakta, M.; Vallejos, C. E.; Correll, M. J.; Boote, K. J.; Fernandes, J. M. C.; Hölbig, C. A.; Hoogenboom, G.

10.1101/2021.02.02.429409 — genomics — Posted on 2021-02-03

3903 SYSTEM ANALYSIS OF THE SEQUENCING QUALITY OF HUMAN WHOLE EXOME SAMPLES ON BGI NGS PLATFORM

Belova, V.; Pavlova, A.; Afasizhev, R.; Moskalenko, V.; Korzhanova, M.; Cheranev, V.; Krivoy, A.; Nikashin, B.; Bulusheva, I.; Rebrikov, D.; Korostin, D.

10.1101/2021.02.02.429394 — genomics — Posted on 2021-02-03

3904 Die hard in Lake Bourget! The case of Planktothrix rubescens

Moiron, M.; Rimet, F.; Girel, C.; Jacquet, S.

10.1101/2021.02.02.429300 — ecology — Posted on 2021-02-03

3905 Designing fisheries restricted areas using standard fishery survey data: a novel multilevel spatio-temporal approach

Paradinas, I.; Gimenez, J.; Conesa, D.; Lopez-Quilez, A.; Pennino, M. G.

10.1101/2021.02.02.429345 — ecology — Posted on 2021-02-03

3906 Climate, latitude, and land cover predict flying insect biomass across a German malaise trap network

Welti, E. A. R.; Zajicek, P.; Ayasse, M.; Bornholdt, T.; Buse, J.; Dziock, F.; Engelmann, R. A.; Englmeier, J.; Fellendorf, M.; Forschler, M. I.; Frenzel, M.; Fricke, U.; Ganuza, C.; Hippke, M.; Hoenselaar, G.; Kaus-Thiel, A.; Mandery, K.; Marten, A.; Monaghan, M. T.; Morkel, C.; Muller, J.; Puffpaff, S.; Redlich, S.; Richter, R.; Rojas Botero, S.; Scharnweber, T.; Scheiffarth, G.; Schmidt Yanez, P.; Schumann, R.; Seibold, S.; Steffan-Dewenter, I.; Stoll, S.; Tobisch, C.; Twietmeyer, S.; Uhler, J.; Vogt, J.; Weis, D.; Weisser, W. W.; Wilmking, M.; Haase, P.

10.1101/2021.02.02.429363 — ecology — Posted on 2021-02-03

3907 Consciously detecting and recognizing a stimulus without knowing what it looks like

Rimsky-Robert, D.; Lisi, M.; Nous, C.; Sergent, C.

10.1101/2021.02.02.429359 — neuroscience — Posted on 2021-02-03

3908 Unravelling the Physiological Correlates of Mental Workload Variations in Tracking and Collision Prediction Tasks: Implications for Air Traffic Controllers

10.1101/2021.02.02.428702 — neuroscience — Posted on 2021-02-03

3909 Active Inference as a Framework for Brain-Computer Interfaces

Ather, S. H.

10.1101/2021.02.02.429272 — neuroscience — Posted on 2021-02-03

3910 Alpha oscillations shape sensory representation and perceptual accuracy

Zhou, Y. J.; Iemi, L.; Schoffelen, J.-M.; de Lange, F. P.; Haegens, S.

10.1101/2021.02.02.429418 — neuroscience — Posted on 2021-02-03

3911 Artificial light at night leads to circadian disruption in a songbird: integrated evidence from behavioural, genomic and metabolomic data

Dominoni, D. M.; de Jong, M.; van Oers, K.; O'Shaughnessy, P. J.; Blackburn, G.; Atema, E.; Mateman, C. A.; D'Amelio, P. B.; Trost, L.; Bellingham, M.; Clark, J.; Visser, M.; Helm, B.

10.1101/2020.12.18.423473 — zoology — Posted on 2021-02-03

3912 An updated staging system for cephalochordate development: one table suits them all

Carvalho, J. E.; Lahaye, F.; Yong, L. W.; Croce, J. C.; Escriva, H.; Yu, J.-K.; Schubert, M.

10.1101/2020.05.26.112193 — developmental biology — Posted on 2021-02-03

3913 Sleeping at the Switch

Bouchard, M.; Lina, J.-M.; Gaudreault, P.-O.; Lafreniere, A.; Dube, J.; Gosselin, N.; Carrier, J.

10.1101/2021.02.02.429396 — neuroscience — Posted on 2021-02-03

3914 Encoding of motion by spatial and temporal frequency in the human middle temporal cortex measured by 7T fMRI

Gaglianese, A.; Fracasso, A.; Fernandes, F. G.; Harvey, B. M.; Dumoulin, S. O.; Petridou, N.

10.1101/2021.02.01.429141 — neuroscience — Posted on 2021-02-03

3915 Effect of number and placement of EEG electrodes onmeasurement of neural tracking of speech

Montoya Martinez, J.; Vanthornhout, J.; Bertrand, A.; Francart, T.

10.1101/800979 — neuroscience — Posted on 2021-02-03

3916 cGMP signaling: probing antagonistic cyclic nucleotide platelet signals by modeling and experiment

Dandekar, T.; Friebe, A.; Feil, R.; Dittrich, M.; Breitenbach, T.; Englert, N.; Osmanoglu, O.; rukoyatkina, n.; Wangorsch, G.; Butt, E.; Gambaryan, S.

10.1101/2021.02.01.429103 — systems biology — Posted on 2021-02-03

3917 Computational hypothesis: How Intra-hepatic functional heterogeneity may influence the cascading progression of free fatty acid-induced non-alcoholic fatty liver disease (NAFLD)

Holzhuetter, H.-G.; Berndt, N.

10.1101/2020.05.28.120626 — systems biology — Posted on 2021-02-03

3918 High-throughput fluorescent assay for inhibitor screening of proteases from RNA viruses

Cihlova, B.; Huskova, A.; Böserle, J.; Nencka, R.; Boura, E.; Silhan, J.

10.1101/2020.10.27.357418 — biochemistry — Posted on 2021-02-03

3919 Pluripotent stem cell SOX9 and INS reporters facilitate differentiation into insulin-producing cells

Dettmer, R.; Niwolik, I.; Mehmeti, I.; Jörns, A.; Naujok, O.

10.1101/2021.02.02.429390 — developmental biology — Posted on 2021-02-03

3920 Extracellular matrix stiffness regulates degradation of the Hippo kinase MST2 via SCFβTrCP

Fiore, A. P. Z. P.; da Silva, A. M. R.; Ribeiro, H. V.; Manucci, A. C.; Ribeiro, P. d. F.; Silva Botelho, M. C.; Oliveira, P. S. L.; Pagano, M.; Bruni-Cardoso, A.

10.1101/2021.01.31.429078 — cell biology — Posted on 2021-02-03

3921 Factors affecting bacterial community dynamics and volatile metabolite profiles of Thai traditional salt fermented fish

Det-udom, R.; Settachaimongkon, S.; Chancharoonpong, C.; Suphamityotin, P.; Suriya, A.; Prakitchaiwattana, C.

10.1101/2021.02.02.429487 — microbiology — Posted on 2021-02-03

3922 Horizontal gene transfer of a unique nif island drives convergent evolution of free-living N2-fixing Bradyrhizobium

Tao, J.; Wang, S.; Liao, T.; Luo, H.

10.1101/2021.02.03.429501 — microbiology — Posted on 2021-02-03

3923 Semi-quantitative detection for L-asparaginase producing fungi and the impact of carbon and nitrogen sources on enzyme activity

Osman, A. A.; Hamed, M.; Ates, M.

10.1101/2021.02.02.429175 — microbiology — Posted on 2021-02-03

3924 Systematic analysis of brain lactate and pH levels in 65 animal models related to neuropsychiatric conditions

10.1101/2021.02.02.428362 — neuroscience — Posted on 2021-02-03

3925 The structural and electrophysiological properties of progesterone receptor expressing neurons vary along the anterior-posterior axis of the ventromedial hypothalamus and undergo local changes across the reproductive cycle

Dias, I. C.; Gutierrez-Castellanos, N.; Ferreira, L.; Lima, S. Q.

10.1101/2021.02.02.429415 — neuroscience — Posted on 2021-02-03

3926 Modeling of histone modifications reveals formation mechanism and function of bivalent chromatin

Zhao, W.; Qiao, L.; Yan, S.; Nie, Q.; Zhang, L.

10.1101/2021.02.03.429504 — systems biology — Posted on 2021-02-03

3927 Assigning Secondary Structure in Proteins using AI

Antony, J. V.; Balakrishnan, J. P.; Madhu, P.

10.1101/2021.02.02.429329 — bioinformatics — Posted on 2021-02-03

3928 Identification of novel inner membrane complex and apical annuli proteins of the malaria parasite Plasmodium falciparum

Wichers, J. S.; Wunderlich, J.; Heincke, D.; Pazicky, S.; Strauss, J.; Schmitt, M.; Kimmel, J.; Wilcke, L.; Scharf, S.; von Thien, H.; Burda, P.-C.; Spielmann, T.; Loew, C.; Filarsky, M.; Bachmann, A.; Gilberger, T. W.

10.1101/2021.02.03.428885 — cell biology — Posted on 2021-02-03

3929 Proximity-labeling reveals novel host and parasite proteins at the Toxoplasma parasitophorous vacuole membrane

Cygan, A. M.; Jean Beltran, P. M.; Branon, T. C.; Ting, A. Y.; Carr, S. A.; Boothroyd, J. C.

10.1101/2021.02.02.429490 — microbiology — Posted on 2021-02-03

3930 ChIPuana: from raw data to epigenomic dynamics

Daunesse, M.; Legendre, R.; Varet, H.; Pain, A.; Chica, C.

10.1101/2021.02.02.429342 — bioinformatics — Posted on 2021-02-03

3931 The anterior cingulate cortex and its role in controlling contextual fear memory to predatory threats.

de Lima, M. A. X.; Baldo, M. V. C.; de Oliveira, F. A.; Canteras, N. S.

10.1101/2021.02.02.429419 — neuroscience — Posted on 2021-02-03

3932 Replacement of microglia by brain-engrafted macrophages provide long term protection against brain irradiation and concussive injury

Feng, X.; Frias, E.; Paladini, M.-S.; Chen, D.; Boosalis, Z.; Becker, M.; Gupta, S.; Liu, S.; Gupta, N.; Rosi, S.

10.1101/794354 — neuroscience — Posted on 2021-02-03

3933 Evidence that standard metabolic rate and risk-taking to breathe air are linked to boldness, activity level and exploratory behaviour in a catfish.

McKenzie, D. J.; Belao, T. C.; Killen, S. S.; Blasco, F. R.; Svendsen, M. B. S.; Rantin, F. T.

10.1101/2021.02.02.429387 — animal behavior and cognition — Posted on 2021-02-03

3934 Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches

Ketteler, R.; Tsefou, E.; Walker, A. S.; Clark, E. H.; Hicks, A. R.; Luft, C.; Takeda, K.; Watanabe, T.; Ramazio, B.; Staddon, J. M.; Briston, T.

10.1101/2021.02.02.429344 — neuroscience — Posted on 2021-02-02

3935 A feed-forward Ca2+-dependent mechanism boosting glycolysis and OXPHOS by activating Aralar-malate-aspartate shuttle, upon neuronal stimulation

Perez-Liebana, I.; Juaristi, I.; Gonzalez-Sanchez, P.; Gonzalez-Moreno, L.; Rial, E.; Podunavac, M.; Zakarian, A.; Molgo, J.; Pardo, B.; Satrustegui, J.; del Arco, A.

10.1101/2021.02.02.429391 — neuroscience — Posted on 2021-02-03

3936 Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer

Pelka, K.; Hofree, M.; Chen, J.; Sarkizova, S.; Pirl, J. D.; Jorgji, V.; Bejnood, A.; Dionne, D.; Ge, W. H.; Xu, K. H.; Chao, S. X.; Zollinger, D. R.; Lieb, D. J.; Reeves, J. W.; Fuhrman, C. A.; Hoang, M. L.; Delorey, T.; Nguyen, L. T.; Waldman, J.; Klapholz, M.; Wakiro, I.; Cohen, O.; Smillie, C. S.; Cuoco, M. S.; Wu, J.; Su, M.-j.; Yeung, J.; Vijaykumar, B.; Magnuson, A. M.; Asinovski, N.; Moll, T.; Goder-Reiser, M. N.; Applebaum, A. S.; Brais, L. K.; DelloStritto, L. K.; Denning, S. L.; Phillips, S. T.; Hill, E. K.; Meehan, J. K.; Frederick, D. T.; Sharova, T.; Kanodia, A.; Todres, E. Z.; J

10.1101/2021.01.30.426796 — cancer biology — Posted on 2021-02-02

3937 DRDOCK: A Drug Repurposing platform integrating automated docking, simulations and a log-odds-based drug ranking scheme

Tsai, K.-L.; Yang, L.-W.

10.1101/2021.01.31.429052 — bioinformatics — Posted on 2021-02-02

3938 Kinesin-3 and kinesin-1 motors direct basement membrane protein secretion to a basal sub-region of the basolateral plasma membrane in epithelial cells

Zajac, A. L.; Horne-Badovinac, S.

10.1101/2021.01.31.429062 — cell biology — Posted on 2021-02-02

3939 Neural Fragility as an EEG Marker of the Seizure Onset Zone

Li, A.; Huynh, C.; Fitzgerald, Z.; Cajigas, I.; Brusko, D.; Claudio, A.; Jagid, J.; Kanner, A.; Hopp, J.; Chen, S.; Haagensen, J.; Johnson, E.; Crone, N.; Anderson, W.; Inati, S.; Zaghloul, K.; Bulacio, J.; Martinez, J.; Sarma, S.

10.1101/862797 — neuroscience — Posted on 2021-02-02

3940 Modeling autism-associated SHANK3 deficiency using human cortico-striatal organoids generated from single neural rosettes

Wang, Y.; Chiola, S.; Yang, G.; Russell, C.; Armstrong, C. J.; Wu, Y.; Spampanato, J.; Tarboton, P.; Chang, A. N.; Harmin, D. A.; Vezzoli, E.; Besusso, D.; Cui, J.; Cattaneo, E.; Kubanek, J.; Shcheglovitov, A.

10.1101/2021.01.25.428022 — neuroscience — Posted on 2021-02-02

3941 Animal-appropriate housing of ball pythons (Python regius)-- Behavior-based evaluation of two types of housing systems

Hollandt, T.; Baur, M.; Wöhr, A.-C.

10.1101/2021.02.02.429328 — animal behavior and cognition — Posted on 2021-02-02

3942 Transcriptional Profiling Reveals the Transcription Factor Networks Regulating the Survival of Striatal Neurons

Yang, L.; Su, Z.; Wang, Z.; Li, Z.; Shang, Z.; Du, H.; Liu, G.; Qi, D.; Yang, Z.; Xu, Z.; Zhang, Z.

10.1101/2020.05.20.105585 — neuroscience — Posted on 2021-02-02

3943 Evidence for efficient non-evaporative leaf-to-air heat dissipation in a pine forest under drought conditions

Muller, J. D.; Rotenberg, E.; Tatarinov, F.; Oz, I.; Yakir, D.

10.1101/2021.02.01.429145 — ecology — Posted on 2021-02-02

3944 DAZL regulates mRNA deadenylation independently of translation in germ cells

Smith, R. W.; Gorgoni, B.; Johnston, Z. C.; Richardson, W. A.; Grieve, K. M.; Anderson, R. C.; Gray, N. K.

10.1101/2021.02.02.429436 — molecular biology — Posted on 2021-02-02

3945 A large panel of chicken cells are invaded in vivo by Salmonella Typhimurium even when depleted of all known invasion factors

Roche, S. M.; Holbert, S.; Le Vern, Y.; Rossignol, C.; Rossignol, A.; Velge, P.; Virlogeux-Payant, I.

10.1101/2020.11.17.386375 — microbiology — Posted on 2021-02-02

3946 Braiding Braak and Braak: Staging patterns and model selection in network neurodegeneration

Putra, P.; Thompson, T. B.; Goriely, A.

10.1101/2021.01.21.427609 — neuroscience — Posted on 2021-02-02

3947 Cubam receptor-mediated endocytosis in hindgut-derived pseudoplacenta of a viviparous teleost Xenotoca eiseni

Iida, A.; Sano, K.; Inokuchi, M.; Suzuki, T.; Kuriki, M.; Sogabe, M.; Susaki, D.; Tonosaki, K.; Kinoshita, T.; Hondo, E.

10.1101/2021.02.01.429082 — zoology — Posted on 2021-02-02

3948 Facilitation drives estrogen receptor positive (ER+) breast cancer growth and survival under drug pressure

Emond, R.; Griffiths, J. I.; Grolmusz, V. K.; Sousa, R. S.; Bild, A. H.; Adler, F. R.

10.1101/2021.02.01.429214 — systems biology — Posted on 2021-02-02

3949 Characterization of novel regulatory modules controlling leaf angle in maize

Wang, X.; Wang, X.; Sun, S.; Tu, X.; Lin, K.; Qin, L.; Wang, X.; Li, G.; Zhong, S.; Li, P.

10.1101/2021.02.02.429433 — plant biology — Posted on 2021-02-02

3950 Mitochondrial ATP Synthase Subunit d, a Component of the Peripheral Stalk, is Essential for Growth and Heat Stress Tolerance in Arabidopsis thaliana.

Liu, T.; Arsenault, J.; Vierling, E.; Kim, M.

10.1101/2021.02.02.429459 — plant biology — Posted on 2021-02-02

3951 The Arabidopsis AAC Proteins CIL and CIA2 Are Sub-functionalized Paralogs involved in Chloroplast Development

Li, M.; Ruwe, H.; Melzer, M.; Junker, A.; Hensel, G.; Tschiersch, H.; Schwenkert, S.; Chamas, S.; Schmitz-Linneweber, C.; Boerner, T.; Stein, N.

10.1101/2021.02.02.429330 — plant biology — Posted on 2021-02-02

3952 Teosinte introgression modulates phosphatidylcholine levels and induces early maize flowering time

Rodriguez-Zapata, F.; Barnes, A. C.; Blocher-Juarez, K. A.; Gates, D. J.; Kur, A.; Wang, L.; Jensen, S. E.; Estevez-Palmas, J. M. M.; Janzen, G. M.; Crow, T. M.; Aguilar-Rangel, R.; Demesa-Arevalo, E.; Skopelitis, T.; Perez-Limon, S.; Stutts, W. L.; Thomson, P. M.; Chiu, Y.-C.; Jackson, D.; Fiehn, O.; Runcie, D.; Buckler, E. S.; Ross-Ibarra, J.; Hufford, M.; Sawers, R. J.; Rellan-Alvarez, R.

10.1101/2021.01.25.426574 — plant biology — Posted on 2021-02-02

3953 Strategies of grain number determination differentiate barley row-types

Venkatasubbu, T.; Koppolu, R.; Schnurbusch, T.

10.1101/2020.08.31.275446 — plant biology — Posted on 2021-02-02

3954 Increased energy expenditure and protection from diet-induced obesity in mice lacking the cGMP-specific phosphodiesterase, PDE9

Ceddia, R. P.; Liu, D.; Shi, F.; Mishra, S.; Kass, D. A.; Collins, S.

10.1101/2021.02.02.429406 — physiology — Posted on 2021-02-02

3955 Akr1d1-/- mice have a sexually dimorphic metabolic phenotype with reduced fat mass, increased insulin sensitivity and hypertriglyceridemia in males

Gathercole, L. L.; Nikolaou, N.; Arvaniti, A.; Harris, S. E.; Poolman, T. M.; Hazlehurst, J. M.; Kratschmar, D. V.; Todorcevic, M.; Moolla, A.; Dempster, N.; Pink, R. C.; Saikali, M. F.; Bentley, L.; Penning, T. M.; Ohlsson, C.; Cummins, C. L.; Poutanen, M.; Odermatt, A.; Cox, R. D.; Tomlinson, J. W.

10.1101/2021.02.02.429227 — physiology — Posted on 2021-02-02

3956 Single-cell analysis reveals the pan-cancer invasiveness-associated transition of adipose-derived stromal cells into COL11A1-expressing cancer-associated fibroblasts

Zhu, K.; Cai, L.; Cui, C.; Anastassiou, D.

10.1101/2020.06.23.166066 — cancer biology — Posted on 2021-02-02

3957 Blinking Statistics and Molecular Counting in direct Stochastic Reconstruction Microscopy (dSTORM)

Patel, L.; Williamson, D.; Owen, D. M.; Cohen, E. A. K.

10.1101/834572 — biophysics — Posted on 2021-02-02

3958 Polaratio: A magnitude-contingent monotonic correlation metric and its improvements to scRNA-seq clustering

Wang, V.; Cicalese, P. A.; Louis Sam Titus, A. S. C.; Mohan, C.

10.1101/2020.12.20.423308 — bioinformatics — Posted on 2021-02-02

3959 Computational identification and experimental characterization of preferred downstream positions in human core promoters

Dreos, R.; Malachi, N.; Sloutskin, A.; Bucher, P.; Juven-Gershon, T.

10.1101/2021.02.02.429413 — bioinformatics — Posted on 2021-02-02

3960 A metabolic CRISPR-Cas9 screen in Chinese hamster ovary cells identifies glutamine-sensitive genes

Karottki, K. J. l. C.; Hefzi, H.; Li, S.; Pedersen, L. E.; Spahn, P.; Joshi, C.; Ruckerbauer, D.; Bort, J. H.; Thomas, A.; Lee, J. S.; Borth, N.; Lee, G. M.; Kildegaard, H. F.; Lewis, N. E.

10.1101/2020.05.07.081604 — bioengineering — Posted on 2021-02-02

3961 Is energetics or competition a stronger driver of male smallmouth bass seasonal reproductive timing?

Laroche, R. A. S.; Weinersmith, K. L.; Angeloni, L.; Baylis, J. R.; Newman, S. P.; Egan, S. P.; Wiegmann, D. D.

10.1101/2021.01.30.428956 — animal behavior and cognition — Posted on 2021-02-02

3962 Knockdown of Dnmt1 links Gene body DNA methylation to regulation of gene expression and maternal-zygotic transition in the wasp Nasonia

Arsala, D.; Wu, X.; Yi, S. V.; Lynch, J. A.

10.1101/2021.02.02.429402 — genomics — Posted on 2021-02-02

3963 Chromosome-level genome assemblies of the malaria vectors Anopheles coluzzii and Anopheles arabiensis

Zamyatin, A.; Avdeyev, P.; Liang, J.; Sharma, A.; Chen, C.; Lukyanchikova, V.; Alexeev, N.; Tu, Z.; Alekseyev, M. A.; Sharakhov, I. V.

10.1101/2020.09.29.318477 — genomics — Posted on 2021-02-02

3964 Myoglobin primary structure reveals multiple convergent transitions to semi-aquatic life in the world smallest mammalian divers

He, K.; Eastman, T. G.; Czolacz, H.; Li, S.; Shinohara, A.; Kawada, S.-i.; Springer, M.; Berenbrink, M.; Campbell, K. L.

10.1101/2021.01.14.426706 — evolutionary biology — Posted on 2021-02-02

3965 Quantifying cell transitions in C. elegans with data-fitted landscape models

Camacho-Aguilar, E.; Warmflash, A.; Rand, D. A.

10.1101/2021.01.22.426019 — developmental biology — Posted on 2021-02-02

3966 EGR4-dependent decrease of UTF1 is associated with failure to reserve spermatogonial stem cells in infertile men

Di Persio, S.; Tekath, T.; Siebert-Kuss, L. M.; Cremers, J.-F.; Wistuba, J.; Li, X.; Meyer zu Hoerste, G.; Drexler, H. C.; Wyrwoll, M. J.; Tuettelmann, F.; Dugas, M.; Kliesch, S.; Schlatt, S.; Laurentino, S.; Neuhaus, N.

10.1101/2021.02.02.429371 — molecular biology — Posted on 2021-02-02

3967 Spray-induced gene silencing for disease control is dependent on the efficiency of pathogen RNA uptake

Qiao, L.; Lan, C.; Capriotti, L.; Ah-Fong, A.; Nino Sanchez, J.; Hamby, R.; Heller, J.; Zhao, H.; Glass, N. L.; Judelson, H. S.; Mezzetti, B.; Niu, D.; Jin, H.

10.1101/2021.02.01.429265 — microbiology — Posted on 2021-02-02

3968 Source identity shapes spatial preference in primary auditory cortex during active navigation

Amaro, D.; Ferreiro, D. N.; Grothe, B.; Pecka, M.

10.1101/2021.01.05.425444 — neuroscience — Posted on 2021-02-02

3969 Social Reactivation of Fear Engrams Enhances Recall and Reinstatement

Finkelstein, A. B.; Leblanc, H.; Cole, R.; Gallerani, T.; Vieira, A.; Zaki, Y.; Ramirez, S.

10.1101/2021.01.07.425728 — neuroscience — Posted on 2021-02-02

3970 Norepinephrine and glucocorticoids modulate chronic unpredictable stress-induced increase in the type 2 CRF and glucocorticoid receptors in brain structures related to the HPA axis activation.

Malta, M. B.; Martins, J.; Novaes, L. S.; dos Santos, N. B.; Sita, L. V.; Camarini, R.; Scavone, C.; Bittencourt, J. C.; Munhoz, C. D.

10.1101/2021.02.02.429424 — neuroscience — Posted on 2021-02-02

3971 Angiotensin-II modulates GABAergic neurotransmission in the mouse substantia nigra.

Amberg, G.; Singh, M.; Vigh, J.

10.1101/2021.02.02.429274 — neuroscience — Posted on 2021-02-02

3972 Sensory experience selectively reorganizes the late component of evoked responses

Bermudez Contreras, E.; Gomez Palacio-Schjetnan, A.; Luczak, A.; Mohajerani, M. H.

10.1101/2020.09.30.321547 — neuroscience — Posted on 2021-02-02

3973 Single calcium channel nanodomains drive presynaptic calcium entry at individual lamprey reticulospinal presynaptic terminals

Ramachandran, S.; Rodriguez, S.; Potcoava, M.; Alford, S.

10.1101/2021.02.02.429388 — neuroscience — Posted on 2021-02-02

3974 Mapping the contents of consciousness during musical imagery

Regev, M.; Halpern, A. R.; Owen, A. M.; Patel, A. D.; Zatorre, R. J.

10.1101/2020.11.20.391375 — neuroscience — Posted on 2021-02-02

3975 PDE9 Inhibition Activates PPARa to Stimulate Mitochondrial Fat Metabolism and Reduce Cardiometabolic Syndrome

Mishra, S.; Hahn, V.; Sadagopan, N.; Dunkerly-Eyring, B.; Rodriguez, S.; Sarver, D. C.; Ceddia, R. P.; Murphy, S.; Knutsdottir, H.; Jani, V.; Ashok, D.; Oeing, C. U.; O'Rourke, B.; Sharma, K.; Gangoiti, J.; Sears, D. D.; Wong, G. W.; Collins, S.; Kass, D. A.

10.1101/2021.02.02.429442 — physiology — Posted on 2021-02-02

3976 Characterisation of tumour immune microenvironment remodelling following oncogene inhibition in preclinical studies using an optimised imaging mass cytometry workflow

van Maldegem, F.; Valand, K.; Cole, M.; Patel, H.; Angelova, M.; Rana, S.; Colliver, E.; Enfield, K.; Bah, N.; Tsang, V.; Mugarza, E.; Moore, C.; Hobson, P.; Levi, D.; Molina, M.; Swanton, C.; Downward, J.

10.1101/2021.02.02.429358 — cancer biology — Posted on 2021-02-02

3977 H3K27me3 mediated KRT14 upregulation promotes TNBC peritoneal metastasis

Verma, A.; Singh, A.; Nengroo, M. A.; Saini, K.; Sinha, A.; Singh, A. K.; Datta, D.

10.1101/2021.02.02.429349 — cancer biology — Posted on 2021-02-02

3978 Analysis of gastric cancer transcriptome allows the identification of histotype specific molecular signatures with prognostic potential

Carino, A.; Graziosi, L.; Marchiano, S.; Biagioli, M.; Marino, E.; Sepe, V.; Zampella, A.; Distrutti, E.; Donini, A.; Fiorucci, S.

10.1101/2021.02.02.429357 — cancer biology — Posted on 2021-02-02

3979 Refinement of α-synuclein ensembles against SAXS data: Comparison of force fields and methods

Ahmed, M. C.; Skaanning, L. K.; Jussupow, A.; Newcombe, E. A.; Kragelund, B. B.; Camilloni, C.; Langkilde, A. E.; Lindorff-Larsen, K.

10.1101/2021.01.15.426794 — biophysics — Posted on 2021-02-02

3980 Genotyping common, large structural variations in 5,202 genomes using pangenomes, the Giraffe mapper, and the vg toolkit

Siren, J.; Monlong, J.; Chang, X.; Novak, A. M.; Eizenga, J. M.; Markello, C.; Sibbesen, J. A.; Hickey, G.; Chang, P.-C.; Carroll, A.; Gupta, N.; Gabriel, S.; Blackwell, T. W.; Ratan, A.; Taylor, K. D.; Rich, S. S.; Rotter, J. I.; Haussler, D.; Garrison, E.; Paten, B.

10.1101/2020.12.04.412486 — bioinformatics — Posted on 2021-02-02

3981 4DNvestigator: Time Series Genomic Data Analysis Toolbox

Lindsly, S. M.; Chen, C.; Lu, S.; Ronquist, S.; Dilworth, S.; Perlman, M.; Rajapakse, I.

10.1101/2020.01.08.898387 — bioinformatics — Posted on 2021-02-02

3982 s-aligner: a greedy algorithm for non-greedy de novo genome assembly

Bermudez, J.

10.1101/2021.02.02.429443 — bioinformatics — Posted on 2021-02-02

3983 MS2AI: Automated repurposing of public peptide LC-MS data for machine learning applications

Rehfeldt, T. G.; Krawczyk, K.; Bogebjerg, M.; Schwämmle, V.; Röttger, R.

10.1101/2021.01.27.428375 — bioinformatics — Posted on 2021-02-02

3984 PASV: Automatic protein partitioning and validation using conserved residues

Moore, R. M.; Harrison, A. O.; Nasko, D. J.; Chopyk, J.; Cebeci, M.; Ferrell, B. D.; Polson, S. W.; Wommack, K. E.

10.1101/2021.01.20.427478 — bioinformatics — Posted on 2021-02-02

3985 A transcriptionally distinct subpopulation of healthy acinar cells exhibit features of pancreatic progenitors and PDAC

Gopalan, V.; Singh, A.; Rashidi, F.; Wang, L.; Ruppin, E.; Arda, E.; Hannenhalli, S.

10.1101/2021.01.04.425042 — genomics — Posted on 2021-02-02

3986 Cellular Reprogramming in Bursts and Phases

Alicea, B. J.

10.1101/2021.02.02.429448 — cell biology — Posted on 2021-02-02

3987 Long noncoding RNA VENTHEART is required for cardiomyocyte specification and function

Dashi, A.; Lek Wen, T. W.; Anene, G.; Pan, B.; Autio, M. I.; Tiang, Z.; Hartman, R.; Stenzig, J.; Wei, H.; Chen, G.; Ackers-Johnson, M.; Lim, B.; Walentinsson, A.; Iyer, V.; Jonsson, M.; Foo, R.

10.1101/2021.02.01.429136 — cell biology — Posted on 2021-02-02

3988 AN INULIN-TYPE FRUCTAN ENRICHED EXCLUSIVE ENTERAL NUTRITION FORMULA SUPPRESSES COLITIS THROUGH GUT MICROBIOME MODULATION AND PROMOTING EXPANSION OF ANTI-INFLAMMATORY T CELL SUBSETS

Healey, G. R.; Tsai, K.; Lisko, D. J.; Cook, L.; Vallance, B. A.; Jacobson, K.

10.1101/2021.02.02.429403 — microbiology — Posted on 2021-02-02

3989 Balanced Input from the tRNA Prenyltransferase MiaA Controls the Stress Resistance and Virulence Potential of Extraintestinal Pathogenic Escherichia coli

Blango, M. G.; Fleming, B. A.; Kincannon, W. M.; Tran, A.; Lewis, A. J.; Russell, C. W.; Zhou, Q.; Baird, L. M.; Brannon, J. R.; Beebout, C. J.; Bandarian, V.; Hadjifraniskou, M.; Howard, M. T.; Mulvey, M. A.

10.1101/2021.02.02.429414 — microbiology — Posted on 2021-02-02

3990 Latent gammaherpesvirus exacerbates arthritis and requires age-associated B cells

Mouat, I. C.; Morse, Z. J.; Shanina, I.; Brown, K. L.; Horwitz, M. S.

10.1101/2021.02.02.429395 — immunology — Posted on 2021-02-02

3991 Dynamic modulation of spleen germinal center reactions by gut bacteria during Plasmodium infection

Mandal, R. K.; Denny, J. E.; Namazzi, R.; Opoka, R. O.; Datta, D.; John, C. C.; Schmidt, N. W.

10.1101/2021.02.02.429404 — immunology — Posted on 2021-02-02

3992 Comparing synaptic proteomes across seven mouse models for autism reveals molecular subtypes and deficits in Rho GTPase signaling

Carbonell, A. U.; Freire-Cobo, C.; Deyneko, I. V.; Erdjument-Bromage, H.; Clipperton-Allen, A.; Rasmusson, R.; Page, D. T.; Neubert, T. A.; Jordan, B. A.

10.1101/2021.02.02.429412 — neuroscience — Posted on 2021-02-02

3993 Midbrain microglia exhibit early proliferative and inflammatory responses during aging that are modulated by CX3CR1 and microglial ablation and repopulation

Moca, E. N.; Lecca, D.; Hope, K. T.; Tweedie, D.; Sidhu, S.; Masukawa, L.; Sitoy, H.; Mathew, R.; Saban, D.; Greig, N. H.; De Biase, L. M.

10.1101/2021.02.02.429070 — neuroscience — Posted on 2021-02-02

3994 Severe deficiency of voltage-gated sodium channel NaV1.2 elevates neuronal excitability in adult mice

Zhang, J.; Chen, X.; Eaton, M.; Lai, S.; Park, A.; Ahmad, T. S.; Wu, J.; Ma, Z.; Que, Z.; Hea Lee, J.; Xiao, T.; Li, Y.; Wang, Y.; Olivero-Acosta, M. I.; Schaber, J. A.; Jayant, K.; Huang, Z.; Lanman, N. A.; Skarnes, W. C.; Yang, Y.

10.1101/2021.02.02.429384 — neuroscience — Posted on 2021-02-02

3995 Preference for animate domain sounds in the fusiform gyrus of blind individuals is modulated by shape-action mapping

Bola, L.; Yang, H.; Caramazza, A.; Bi, Y.

10.1101/2020.06.20.162917 — neuroscience — Posted on 2021-02-02

3996 Deficits of Hippocampal RNA Editing and Social Interaction Resulting from Prenatal Stress are Mitigated by Clozapine.

Bristow, G. C.; Dong, E.; Nwabuisi-Heath, E.; Gentile, S.; Guidotti, A.; Sodhi, M.

10.1101/2021.02.02.429408 — neuroscience — Posted on 2021-02-02

3997 Spatial microbial community dynamics using a continuous species interaction model

Swain, A.; Fussell, L.; Fagan, W. F.

10.1101/2021.02.02.429382 — systems biology — Posted on 2021-02-02

3998 A novel positive feedback mechanism of ABI5 phosphorylation by mitogen activated protein kinase-3 regulates ABA signaling in Arabidopsis

Bhagat, P. K.; Verma, D.; Verma, N.; Sinha, A. K.

10.1101/2021.02.02.429361 — plant biology — Posted on 2021-02-02

3999 Colonic epithelial adaptation to EGFR-independent growth induces induces chromosomal instability and is accelerated by prior injury

Chen, T.; Zeineldin, M.; Johnson, B.; Dong, Y.; Narkar, A.; Li, T.; Zhu, J.; Li, R.; Larman, T.

10.1101/2021.02.02.429426 — cancer biology — Posted on 2021-02-02

4000 A novel vascular endothelial growth factor-trap KP-VR2 with enhanced ligand blocking

Kim, M.-R.; Kim, B.; Na, Y.; Yoo, J.; Kim, S.-H.; Seo, I.-R.

10.1101/2021.02.02.429416 — cancer biology — Posted on 2021-02-02

4001 Hybrid multisite silicon neural probe with integrated flexible connector for interchangeable packaging

Novais, A.; Calaza, C.; Fernandes, J.; Fonseca, H.; Gaspar, J.; Jacinto, L.

10.1101/2021.02.02.429112 — bioengineering — Posted on 2021-02-02

4002 Spc1 regulates substrate selection for signal peptidase

Yim, C.; Chung, Y.; Kim, J.; Nilsson, I.; Kim, J.-S.; Kim, H.

10.1101/2021.02.02.429376 — biochemistry — Posted on 2021-02-02

4003 Nascent polypeptide within the exit tunnel ensures continuous translation elongation by stabilizing the translating ribosome

Chadani, Y.; Sugata, N.; Niwa, T.; Ito, Y.; Iwasaki, S.; Taguchi, H.

10.1101/2021.02.02.429294 — biochemistry — Posted on 2021-02-02

4004 The basis of a more contagious 501Y.V1 variant of SARS-COV-2

Zhang, G.; Liu, H.; Zhang, Q.; Wei, P.; Chen, Z.; Aviszus, K.; Yang, J.; Downing, W.; Peterson, S.; Jiang, C.; Liang, B.; Reynoso, L.; Downey, G.; Frankel, S.; Kapper, J.; Marrack, P.

10.1101/2021.02.02.428884 — biochemistry — Posted on 2021-02-02

4005 DNA METHYLATION PROFILING OF A CNIDARIAN-ALGAL SYMBIOSIS USING NANOPORE SEQUENCING

Dimond, J.; Roberts, S.; Nguyen, N.

10.1101/2021.02.01.429278 — genomics — Posted on 2021-02-02

4006 Population size mediates the contribution of high-rate and large-benefit mutations to parallel evolution

Schenk, M. F.; Zwart, M. P.; Hwang, S.; Ruelens, P.; Severing, E.; Krug, J.; de Visser, J. A. G. M.

10.1101/2021.02.02.429281 — evolutionary biology — Posted on 2021-02-02

4007 Improved accuracy for automated counting of a fish in baited underwater videos for stock assessment

Connolly, R.; Fairclough, D.; Jinks, E.; Ditria, E.; Jackson, G.; Lopez-Marcano, S.; Olds, A.; Jinks, K.

10.1101/2021.02.01.429285 — ecology — Posted on 2021-02-02

4008 Chromatin Bridges, not Micronuclei, Activate cGAS after Drug-induced Mitotic Errors in Human Cells

Flynn, P. J.; Koch, P. D.; Mitchison, T. J.

10.1101/2021.02.02.429360 — cell biology — Posted on 2021-02-02

4009 Deep Proteome Profiling of Human Mammary Epithelia at Lineage and Age Resolution

Hinz, S.; Manousopoulou, A.; Miyano, M.; Sayaman, R. W.; Aguilera, K. Y.; Todhunter, M. E.; Lopez, J. C.; Sohn, L. L.; Wang, L. D.; LaBarge, M. A.

10.1101/2021.02.02.429276 — cell biology — Posted on 2021-02-02

4010 RNA-Sequencing of Long-Term Label-Retaining Colon Cancer Stem Cells Identifies Novel Regulators of Quiescence

Regan, J. L.; Schumacher, D.; Staudte, S.; Steffen, A.; Lesche, R.; Toedling, J.; Jourdan, T.; Haybaeck, J.; Mumberg, D.; Henderson, D.; Gyorffy, B.; Regenbrecht, C. R. A.; Keilholz, U.; Schafer, R.; Lange, M.

10.1101/2021.02.02.429354 — cell biology — Posted on 2021-02-02

4011 Mosaic Ends Tagmentation (METa) assembly for extremely efficient construction of functional metagenomic librarie

Crofts, T. S.; McFarland, A. G.; Hartmann, E. M.

10.1101/2021.02.01.429292 — microbiology — Posted on 2021-02-02

4012 Spatial-proteomics reveal in-vivo phospho-signaling dynamics at subcellular resolution

Martinez del Val, A.; Bekker-Jensen, D. B.; Steigerwald, S.; Mehta, A.; Tran, T.; Sikorski, K.; Torres-Vega, E.; Kwasniewicz, E.; Hlin Brynjolfsdottir, S.; Frankel, L. B.; Kjobsted, R.; Krogh, N.; Lundby, A.; Bekker-Jensen, S.; Lund-Johansen, F.; Olsen, J. V.

10.1101/2021.02.02.425898 — systems biology — Posted on 2021-02-02

4013 Facilitation drives estrogen receptor positive (ER+) breast cancer growth and survival under drug pressure

Emond, R.; Griffiths, J. I.; Grolmusz, V. K.; Sousa, R. S.; Bild, A. H.; Adler, F. R.

10.1101/2021.02.01.429214 — systems biology — Posted on 2021-02-02

4014 Transport engineering for improving production and secretion of valuable alkaloids in Escherichia coli

Yamada, Y.; Urui, M.; Oki, H.; Inoue, K.; Matsui, H.; Ikeda, Y.; Nakagawa, A.; Sato, F.; Minami, H.; Shitan, N.

10.1101/2021.02.01.429260 — synthetic biology — Posted on 2021-02-02

4015 Resolving phylogenetic and biochemical barriers to functional expression of heterologous iron-sulphur cluster enzymes

Shomar, H.; Garcia, P. S.; Fernandez-Fueyo, E.; D'Angelo, F.; Pelosse, M.; Manuel, R. R.; Büke, F.; Liu, S.; van den Broek, N.; Duraffourg, N.; de Ram, C.; Pabst, M.; Gribaldo, S.; Py, B.; Ollagnier de Choudens, S.; Bokinsky, G.; Barras, F.

10.1101/2021.02.02.429153 — synthetic biology — Posted on 2021-02-02

4016 Bioprinting transgenic plant cells for production of a recombinant biodefense agent

Varma, A.; Gemeda, H. B.; McNulty, M. J.; McDonald, K.; Nandi, S.; Knipe, J.

10.1101/2021.02.01.429263 — plant biology — Posted on 2021-02-02

4017 Genetic autonomy and low singlet oxygen yield support kleptoplast functionality in photosynthetic sea slugs

Havurinne, V.; Handrich, M.; Antinluoma, M.; Khorobrykh, S.; Gould, S.; Tyystjärvi, E.

10.1101/2021.02.02.429324 — plant biology — Posted on 2021-02-02

4018 Coupling Comprehensive Transcriptome-Metabolome Association and Phylogenetic Analysis Speed Dissecion of Polyphyllins Biosynthetic Pathway

hua, x.; Song, W.; Wang, K.; Yin, X.; Hao, c.; Xu, Z.; Su, T.; Xue, z.

10.1101/2021.02.01.429277 — plant biology — Posted on 2021-02-02

4019 Chemical screen identifies a small molecule antagonizing JA-Ile perception and auxin responses.

Chini, A.; Monte, I.; Fernandez-Barbero, G.; Boter, M.; Hicks, G.; Raikhel, N. V.; Solano, R.

10.1101/2021.02.02.429350 — plant biology — Posted on 2021-02-02

4020 PolyQ expansion does not alter the Huntingtin-HAP40 complex

Huang, B.; Guo, Q.; Niedermeier, M. L.; Cheng, J.; Engler, T.; Maurer, M.; Pautsch, A.; Baumeister, W.; Stengel, F.; Kochanek, S.; Fernandez-Busnadiego, R.

10.1101/2021.02.02.429316 — biophysics — Posted on 2021-02-02

4021 Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology

Ng, C. A.; Farr, J.; Young, P.; Windley, M. J.; Perry, M. D.; Hill, A. P.; Vandenberg, J. I.

10.1101/2021.02.02.427891 — biophysics — Posted on 2021-02-02

4022 Predicting Epigenomic Functions of Genetic Variants in the Context of Neurodevelopment via Deep Transfer Learning

Lai, B.; Qian, S.; Zhang, H.; Zhang, S.; Kozlova, A.; Duan, J.; Xu, J.; He, X.

10.1101/2021.02.02.429064 — bioinformatics — Posted on 2021-02-02

4023 PDAUG - a Galaxy based toolset for peptide library analysis, visualization, and machine learning modeling

Joshi, J.; Blankenberg, D.

10.1101/2021.02.02.429203 — bioinformatics — Posted on 2021-02-02

4024 Amplification of the epigenetic (gestational) age acceleration signal

Lee, Y.; Bohlin, J.

10.1101/2021.02.02.429312 — bioinformatics — Posted on 2021-02-02

4025 Identification of APOE4 modulators, targeted therapeutic candidates in Coronary Artery Disease, using Molecular Docking studies

Hazarika, L.; Sen, S.; Zawar, A.; Doshi, J.

10.1101/2021.02.02.429307 — bioinformatics — Posted on 2021-02-02

4026 Functionalized extracellular matrix scaffolds loaded with endothelial progenitor cells promote neovascularization and diabetic wound healing

He, S.; Walimbe, T.; Chen, H.; Gao, K.; Kumar, P.; Wei, Y.; Hao, D.; Liu, R.; Farmer, D. L.; Lam, K.; Zhou, J.; Panitch, A.; Wang, A.

10.1101/2021.02.02.429318 — bioengineering — Posted on 2021-02-02

4027 How coiled-coil assemblies accommodate multiple aromatic residues

Rhys, G. G.; Dawson, W. M.; Beesley, J. L.; Martin, F. J. O.; Brady, L.; Thomson, A. R.; Woolfson, D. N.

10.1101/2021.02.01.429152 — biochemistry — Posted on 2021-02-02

4028 Validation and classification of RNA binding proteins identified by mRNA interactome capture

Vaishali, V.; Dimitrova-Paternoga, L.; Haubrich, K.; Sun, M.; Ephrussi, A.; Hennig, J.

10.1101/2021.02.02.429302 — biochemistry — Posted on 2021-02-02

4029 Impact of central complex lesions on visual orientation in ants: Turning behaviour, but not the overall movement direction, is disrupted

Dell-Cronin, S.; Buehlmann, C.; Diyalagoda Pathirannahelage, A.; Goulard, R.; Webb, B.; Niven, J. E.; Graham, P.

10.1101/2021.02.02.429334 — animal behavior and cognition — Posted on 2021-02-02

4030 Combined influence of food availability and agricultural intensification on a declining aerial insectivore

Garrett, D. R.; Pelletier, F.; Garant, D.; Belisle, M.

10.1101/2021.02.02.427782 — ecology — Posted on 2021-02-02

4031 Progressive domain segregation in early embryonic development and underlying correlation to genetic and epigenetic changes

Quan, H.; Tian, H.; Liu, S.; Xue, Y.; Zhang, Y.; Xie, W.; Gao, Y. Q.

10.1101/2021.02.02.429282 — developmental biology — Posted on 2021-02-02

4032 Identification of a Nervous System Gene Expression Signature in Colon Cancer Stem Cells Reveals a Role for Neural Crest Regulators EGR2 and SOX2 in Tumorigenesis

10.1101/2021.02.02.428317 — cell biology — Posted on 2021-02-02

4033 Super-resolved local recruitment of CLDN5 to filtration slits implicates a direct relationship with podocyte foot process effacement

Tesch, F.; Siegerist, F.; Hay, E.; Artelt, N.; Daniel, C.; Amann, K.; Zimmermann, U.; Kavvadas, P.; Grisk, O.; Chadjichristos, C.; Endlich, K.; Chatziantoniou, C.; Endlich, N.

10.1101/2021.02.02.429338 — cell biology — Posted on 2021-02-02

4034 The MAP She1 coordinates directional spindle positioning by spatially restricting dynein activity

Ecklund, K. H.; Bailey, M. E.; Dietvorst, C. K.; Asbury, C. L.; Markus, S. M.

10.1101/2021.02.02.429374 — cell biology — Posted on 2021-02-02

4035 Cardiac fibroblast GSK-3α mediates adverse myocardial fibrosis via IL-11 and ERK pathway

Umbarkar, P.; Tousif, S.; Singh, A. P.; Anderson, J. C.; Zhang, Q.; Lal, H.

10.1101/2021.02.02.429435 — molecular biology — Posted on 2021-02-02

4036 Role of transmembrane spanning domain 1 in cystic fibrosis transmembrane conductance regulator folding

Patrick, A. E.; Millen, L.; Thomas, P. J.

10.1101/2021.02.02.428178 — molecular biology — Posted on 2021-02-02

4037 Perturbations in 3D genome organization can promote acquired drug resistance

Manjon, A. G.; Peric-Hupkes, D.; Liu, N. Q.; Friskes, A.; Joosten, S.; Teunissen, H.; Aarts, M.; Prekovic, S.; Zwart, W.; de Wit, E.; van Steensel, B.; Medema, R. H.

10.1101/2021.02.02.429315 — molecular biology — Posted on 2021-02-02

4038 Establishing regulated unconventional secretion for production of heterologous proteins

Hussnaetter, K. P.; Philipp, M.; Muentjes, K.; Feldbruegge, M.; Schipper, K.

10.1101/2021.02.02.429340 — molecular biology — Posted on 2021-02-02

4039 Antennal transcriptome analysis and identification of candidate chemosensory genes of the harlequin ladybird beetle, Harmonia axyridis (Pallas) (Coleoptera: Coccinellidae)

Rondoni, G.; Roman, A.; Meslin, C.; Montagne, N.; Conti, E.; Jacquin-Joly, E.

10.1101/2021.02.01.429221 — molecular biology — Posted on 2021-02-02

4040 Outer membrane vesicles derived from Salmonella Typhimurium can deliver Shigella flexneri 2a O-polysaccharide antigen to prevent lethal pulmonary infection in mice

Liu, Q.; Tian, H.; Li, B.; Chen, Y.; Jie, K.; Xu, T.; Song, Z.; Huang, X.

10.1101/2021.02.01.429291 — microbiology — Posted on 2021-02-02

4041 Phenotypic and genotypic characterization of antibiotic Resistant Gram Negative Bacteria isolated in Tabuk City, Saudi Arabia

Alnour, T. M.; Elssaig, E. H.; Ahmed-Abakur, E. H.; Abuduhier, F. M.; Alfifi, K. A. S.; Abusuliman, M. S.; Albalawi, T.

10.1101/2021.02.01.429288 — microbiology — Posted on 2021-02-02

4042 Potential Early Rabies Infection Detected in Two Raccoon Cases by LN34 pan-lyssavirus real-time RT-PCR Assay in Pennsylvania

Dettinger, L.; Gigante, C. M.; Strohecker, M.; Seiders, M.; Patel, P.; Orciari, L. A.; Yager, P.; Lute, J.; Regec, A.; Li, Y.; Xia, D.

10.1101/2021.02.01.429287 — microbiology — Posted on 2021-02-02

4043 Spatial and temporal plasticity of neoantigen-specific T-cell responses bases on characteristics associated to antigen and TCR

10.1101/2021.02.02.428777 — immunology — Posted on 2021-02-02

4044 Voluntary alcohol consumption disrupts coupling of prefrontal cortical activity to arousal

Sipe, G. O.; Linares-Garcia, I.; Nguyen, M.; Vazey, E.; Huda, R.

10.1101/2021.02.01.429229 — neuroscience — Posted on 2021-02-02

4045 Cortico-amygdalar connectivity and externalizing/internalizing behavior in children with neurodevelopmental disorders

Nakua, H.; Hawco, C.; Forde, N. J.; Jacobs, G. R.; Joseph, M.; Voineskos, A.; Wheeler, A. L.; Lai, M.-C.; Szatmari, P.; Kelley, E.; Liu, X.; Georgiades, S.; Nicolson, R.; Schachar, R.; Crosbie, J.; Anagnostou, E.; Lerch, J. P.; Arnold, P. D.; Ameis, S. H.

10.1101/2021.02.01.429143 — neuroscience — Posted on 2021-02-02

4046 Protein lactylation induced by neural excitation

Hagihara, H.; Shoji, H.; Otabi, H.; Toyoda, A.; Katoh, K.; Namihira, M.; Miyakawa, T.

10.1101/2021.02.02.428370 — neuroscience — Posted on 2021-02-02

4047 Mesophyll cells mediate systemic reactive oxygen signaling during wounding or heat stress

I Zandalinas, S.; Mittler, R.

10.1101/2021.02.02.429427 — plant biology — Posted on 2021-02-02

4048 Synergistic Therapy of Doxorubicin with Cationic Anticancer Peptide L-K6 Reverses Multidrug Resistance in Cancer Cells in vitro via P-glycoprotein Inhibition

Wang, C.; Huang, L.; Li, R.; Wang, Y.; Wu, X.; Shang, D.

10.1101/2021.02.02.429308 — pharmacology and toxicology — Posted on 2021-02-02

4049 WILMS TUMORIGENESIS IN HUMAN KIDNEY ORGANOIDS

Waehle, V.; Ungricht, R.; Hoppe, P. S.; Betschinger, J.

10.1101/2021.02.02.429313 — cancer biology — Posted on 2021-02-02

4050 In vivo amyloid-like fibrils produced under stress

Fontana, N. A.; Rosse, A. D.; Watts, A.; Coelho, P. S. R.; Costa-Filho, A. J.

10.1101/2021.02.02.429251 — biophysics — Posted on 2021-02-02

4051 Machine Learning Differentiates Enzymatic and Non-Enzymatic Metals in Proteins

Feehan, R.; Franklin, M. W.; Slusky, J. S. G.

10.1101/2021.02.01.429261 — biophysics — Posted on 2021-02-02

4052 The impact of distributional assumptions in gene-set and pathway analysis: how far can it go wrong?

Ho, C.-H.; Huang, Y.-J.; Lai, Y.-J.; Mukherjee, R.; Hsiao, C. K.

10.1101/2021.02.01.429279 — bioinformatics — Posted on 2021-02-02

4053 ChIPuana: from raw data to epigenomic dynamics

Daunesse, M.; Legendre, R.; Varet, H.; Pain, A.; Chica, C.

10.1101/2021.02.02.429342 — bioinformatics — Posted on 2021-02-02

4054 dcHiC: differential compartment analysis of Hi-C datasets

Wang, J.; Chakraborty, A.; Ay, F.

10.1101/2021.02.02.429297 — bioinformatics — Posted on 2021-02-02

4055 Increased levels of the mitochondrial import factor Mia40 prevent the aggregation of polyQ proteins in the cytosol

Schlagowski, A. M.; Knöringer, K.; Morlot, S.; Sachez Vicente, A.; Boos, F.; Khalid, N.; Ahmed, S.; Schramm, J.; Murschall, L. M.; Haberkant, P.; Stein, F.; Riemer, J.; Westermann, B.; Braun, R. J.; Winklhofer, K. F.; Charvin, G.; Herrmann, J. M.

10.1101/2021.02.02.429331 — biochemistry — Posted on 2021-02-02

4056 Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors

Pandey, S.; Kumari, P.; Baidya, M.; Kise, R.; Cao, Y.; Dwivedi-Agnihotri, H.; Banerjee, R.; Li, X.; Cui, C.; Lee, J.; Kawakami, K.; Chaturvedi, M.; Ranjan, A.; Laporte, S.; Woodruff, T. M.; Inoue, A.; SHUKLA, A. K.

10.1101/2021.02.02.429298 — biochemistry — Posted on 2021-02-02

4057 Pseudogenization of trnT-GGU in chloroplast genomes of the plant family Asteraceae

Abdullah, ; Mehmood, F.; Heidari, P.; Ahmed, I.; Poczai, P.

10.1101/2021.02.01.429200 — evolutionary biology — Posted on 2021-02-02

4058 Endothelial cell senescence exacerbates pulmonary hypertension through Notch-mediated juxtacrine signaling

Ramadhiani, R.; Ikeda, K.; Miyagawa, K.; Ryanto, G. R. T.; Tamada, N.; Suzuki, Y.; Hirata, K.-i.; Emoto, N.

10.1101/2021.02.02.429321 — cell biology — Posted on 2021-02-02

4059 Computational insights into differential interaction of mamalian ACE2 with the SARS-CoV-2 spike receptor binding domain

Lupala, C. S.; Kumar, V.; Su, X.-d.; Wu, C.; Liu, H.

10.1101/2021.02.02.429327 — bioinformatics — Posted on 2021-02-02

4060 Accurate and robust inference of microbial growth dynamics from metagenomic sequencing

Joseph, T. A.; Chlenski, P.; Korem, T.; Pe'er, I.

10.1101/2021.02.02.429365 — bioinformatics — Posted on 2021-02-02

4061 Evolution of ACE2 and SARS-CoV-2 Interplay Across 247 Vertebrates

Zhang, Z.; Zhang, T.; Wu, Q.; Ma, Y.; Liu, W.; Zou, C.

10.1101/2021.01.28.428568 — evolutionary biology — Posted on 2021-02-02

4062 Therapeutic antibodies, targeting the SARS-CoV-2 spike N-terminal domain, protect lethally infected K18-hACE2 mice

Noy-Porat, T.; Mechaly, A.; Levy, Y.; Makdasi, E.; Alcalay, R.; Gur, D.; Aftalion, M.; Falach, R.; Leviatan Ben-Arye, S.; Lazar, S.; Zauberman, A.; Epstein, E.; Chitlaru, T.; Weiss, S.; Achdout, H.; Edgeworth, J. D.; Kikkeri, R.; Yu, H.; Chen, X.; Yitzhaki, S.; Shapira, S. C.; Padler-Karavani, V.; Mazor, O.; Rosenfeld, R.

10.1101/2021.02.02.428995 — immunology — Posted on 2021-02-02

4063 Paradoxical hyperexcitability from NaV1.2 sodium channel loss in neocortical pyramidal cells

Spratt, P. W.; Ben-Shalom, R.; Sahagun, A.; Keeshen, C. M.; Sanders, S. J.; Bender, K. J.

10.1101/2021.02.02.429423 — neuroscience — Posted on 2021-02-02

4064 Cofilin pathology is a new player on α-synuclein-induced spine impairment in models of hippocampal synucleinopathy

Oliveira da Silva, M. I.; Santejo, M.; Babcock, I. W.; Magalhaes, A.; Minamide, L. S.; Castillo, E.; Gerhardt, E.; Fahlbusch, C.; Swanson, R. A.; Outeiro, T. F.; Bamburg, J. R.; Liz, M. A.

10.1101/2021.02.02.425931 — neuroscience — Posted on 2021-02-02

4065 Identifying Cross-Cancer Similar Patients via a Semi-Supervised Deep Clustering Approach

Ay, D.; Tastan, O.

10.1101/2020.11.07.372672 — bioinformatics — Posted on 2021-02-02

4066 A Thermostable, Flexible RNA Vaccine Delivery Platform for Pandemic Response

Gerhardt, A.; Voigt, E.; Archer, M.; Reed, S.; Larson, E.; Van Hoeven, N.; Kramer, R.; Fox, C.; Casper, C.

10.1101/2021.02.01.429283 — bioengineering — Posted on 2021-02-02

4067 Resveratrol And Pterostilbene Potently Inhibit SARS-CoV-2 Replication In Vitro

ter Ellen, B. M.; Dinesh Kumar, N.; Bouma, E. M.; Troost, B.; van de Pol, D. P. I.; van der Ende-Metselaar, H. H.; Apperloo, L.; van Gosliga, D.; van den Berge, M.; Nawijn, M. C.; van der Voort, P. H. J.; Moser, J.; Rodenhuis-Zybert, I. A.; Smit, J. M.

10.1101/2020.09.24.285940 — microbiology — Posted on 2021-02-02

4068 Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products in vitro

He, C.-L.; Huang, L.-Y.; Wang, K.; Gu, C.-J.; Hu, J.; Zhang, G.-J.; Xu, W.; Xie, Y.-H.; Tang, N.; Huang, A.-L.

10.1101/2020.12.13.420406 — microbiology — Posted on 2021-02-02

4069 Isoform-specific functions of Numb in breast cancer progression, metastasis and proteome remodeling.

Zhang, Y.; Dho, S. E.; Simpson, C. D.; Othman, K.; Bondoc, A.; McGlade, C. J.

10.1101/2021.02.01.429237 — cancer biology — Posted on 2021-02-02

4070 Molecular mechanism of N-terminal acetylation by the ternary NatC complex

Deng, S.; Gottlieb, L.; Pan, B.; Supplee, J.; Wei, X.; Petersson, J.; Marmorstein, R.

10.1101/2021.02.01.429250 — biophysics — Posted on 2021-02-02

4071 Sequence-specific minimizers via polar sets

Zheng, H.; Kingsford, C.; Marcais, G.

10.1101/2021.02.01.429246 — bioinformatics — Posted on 2021-02-02

4072 Stratified neural networks in a time-to-event setting

Kuruc, F.; Binder, H.; Hess, M.

10.1101/2021.02.01.429169 — bioinformatics — Posted on 2021-02-02

4073 Rampant prophage movement among transient competitors drives rapid adaptation during infection

Marshall, C. W.; Gloag, E. S.; Lim, C.; Wozniak, D. J.; Cooper, V. S.

10.1101/2021.02.01.429245 — microbiology — Posted on 2021-02-02

4074 Spray-induced gene silencing for disease control is dependent on the efficiency of pathogen RNA uptake

Qiao, L.; Lan, C.; Capriotti, L.; Ah-Fong, A.; Nino Sanchez, J.; Hamby, R.; Heller, J.; Zhao, H.; Glass, N. L.; Judelson, H. S.; Mezzetti, B.; Niu, D.; Jin, H.

10.1101/2021.02.01.429265 — microbiology — Posted on 2021-02-02

4075 Slower prefrontal metastable dynamics during deliberation predicts error trials in a distance discrimination task

Benozzo, D.; La Camera, G.; Genovesio, A.

10.1101/2021.02.01.429249 — neuroscience — Posted on 2021-02-02

4076 Working Memory Representations in Visual Cortex Mediate the Effects of Distraction

Hallenbeck, G. E.; Sprague, T. C.; Rahmati, M. C.; Sreenivasan, K. K.; Curtis, C. E.

10.1101/2021.02.01.429259 — neuroscience — Posted on 2021-02-02

4077 Distinct neurophysiological correlates of the fMRI BOLD signal in the hippocampus and neocortex

Hill, P. F.; Seger, S. E.; Yoo, H. B.; King, D. R.; Lega, B. C.; Rugg, M. D.

10.1101/2021.02.01.429258 — neuroscience — Posted on 2021-02-02

4078 LRH-1 NUTRIGENOMICS: The Provision of Lauric Acid Results in the Endogenous Production of the Liver Receptor Homolog-1 Ligand, Dilauroylphosphatidylcholine, and LRH-1 Transactivation

Klatt, K. C.; Zhang, S.; Malysheva, O. V.; Sun, Z.; Dong, B.; Brenna, J. T.; Moore, D. D.; Roberson, M. S.; Caudill, M. A.

10.1101/2021.02.01.429240 — physiology — Posted on 2021-02-02

4079 Mutant SETBP1 enhances NRAS-driven MAPK pathway activation to promote aggressive leukemia

Carratt, S. A.; Braun, T. P.; Coblentz, C.; Schonrock, Z.; Callahan, R.; Smith, B. M.; Maloney, L.; Foley, A.; Maxson, J. E.

10.1101/2021.02.01.429244 — cancer biology — Posted on 2021-02-02

4080 Discovery of 17 conserved structural RNAs in fungi

Gao, W.; Jones, T. A.; Rivas, E.

10.1101/2021.02.01.429235 — bioinformatics — Posted on 2021-02-02

4081 Autonomous Wireless System for Robust and Efficient Inductive Power Transmission to Multi-Node Implants

Feng, P.; Constandinou, T.

10.1101/2021.02.01.429239 — bioengineering — Posted on 2021-02-02

4082 Combining chemogenomic and gene-dose assays to investigate drug synergy

Gaikani, H.; Smith, A. M.; Lee, A. Y.; Giaever, G.; Nislow, C.

10.1101/2021.02.01.429253 — genomics — Posted on 2021-02-02

4083 The ETS Transcription Factor ERF controls the exit from the naive pluripotent state

Vega-Sendino, M.; Olbrich, T.; Tillo, D.; Tran, A. D.; Domingo, C. N.; Franco, M.; FitzGerald, P. C.; Kruhlak, M.; Ruiz Macias, S.

10.1101/2021.02.01.429223 — developmental biology — Posted on 2021-02-02

4084 Molecular mechanism underlying the non-essentiality of Bub1 for the fidelity of chromosome segregation in human cells

Chen, Q.; Zhang, M.; Pan, X.; Zhou, L.; Yan, H.; Wang, F.

10.1101/2021.02.01.429225 — cell biology — Posted on 2021-02-02

4085 Stage-specific, morphological and molecular markers of encystation in Giardia lamblia

Thomas, E. B.; Sutanto, R.; Johnson, R. S.; Shih, H.-W.; Krtkova, J.; MacCoss, M. J.; Paredez, A. R.

10.1101/2021.02.01.429238 — cell biology — Posted on 2021-02-02

4086 Itaconate and its derivatives repress C2C12 myogenesis via succinate dehydrogenase inhibition

Oh, T.; Hutchins, D.; Mainali, R.; Goslen, K.; Hayes, J.; Quinn, M. A.

10.1101/2021.02.01.429228 — cell biology — Posted on 2021-02-02

4087 Chemogenetic dissection of the primate prefronto-subcortical pathways for working memory and decision-making

Oyama, K.; Hori, Y.; Nagai, Y.; Miyakawa, N.; Mimura, K.; Hirabayashi, T.; Inoue, K.-i.; Suhara, T.; Takada, M.; Higuchi, M.; Minamimoto, T.

10.1101/2021.02.01.429248 — neuroscience — Posted on 2021-02-02

4088 Colonization at birth with human CST IV cervicovaginal microbiota alters development and increases neonatal mortality in mice

Jasarevic, E.; Hill, E. M.; Kane, P. J.; Rutt, L.; Gyles, T.; Folts, L.; Rock, K. D.; Howard, C. D.; Morrison, K. E.; Ravel, J.; Bale, T. L.

10.1101/2021.02.01.429213 — systems biology — Posted on 2021-02-02

4089 Basal-to-classical phenotypic switch of pancreatic cancer cells upon integration into the duodenal epithelium

Bozoky, B.; Fernandez Moro, C.; Strell, C.; Ernberg, I.; Szekely, L.; Gerling, M.; Bozoky, B.

10.1101/2021.02.01.429212 — cancer biology — Posted on 2021-02-02

4090 Variation in Placental microRNA Expression Associates with Familial Cardiovascular Disease

Tehrani, J. M.; Kennedy, E. M.; Tian, F.-Y.; Everson, T. M.; Deyssenroth, M.; Burt, A.; Hermetz, K.; Hao, K.; Chen, J.; Koestler, D. C.; Marsit, C. J.

10.1101/2021.02.01.429202 — genetics — Posted on 2021-02-02

4091 The color pattern inducing gene wingless is expressed in specific cell types of campaniform sensilla of a polka-dotted fruit fly, Drosophila guttifera

Koseki, M.; Tanaka, N. K.; Koshikawa, S.

10.1101/2021.02.01.429284 — developmental biology — Posted on 2021-02-02

4092 Impact of a human gut microbe on Vibrio cholerae host colonization through biofilm enhancement

Barrasso, K.; Chac, D.; Debele, M. D.; Harris, J. B.; LaRocque, R. C.; Midani, F. S.; Qadri, F.; Yan, J.; Weil, A. A.; Ng, W.-L.

10.1101/2021.02.01.429194 — microbiology — Posted on 2021-02-02

4093 Biosynthesis system of Synechan, a sulfated exopolysaccharide, in the model cyanobacterium Synechocystis sp. PCC 6803

Maeda, K.; Okuda, Y.; Enomoto, G.; Watanabe, S.; Ikeuchi, M.

10.1101/2021.02.01.429190 — microbiology — Posted on 2021-02-02

4094 RIM and RIM-binding protein localize synaptic Cav2 channels in a differential manner to regulate transmission in neuronal circuits

Janosi, B.; Liewald, J. F.; Yu, S.-c.; Umbach, S.; Alcantara, I. C.; Bergs, A. C.; Schneider, M. W.; Shao, J.; Gottschalk, A.

10.1101/2021.02.01.429206 — neuroscience — Posted on 2021-02-02

4095 Kv1.1 subunits localize to cardiorespiratory brain networks in mice where their absence induces astrogliosis and microgliosis

Dhaibar, H. A.; Hamilton, K. A.; Glasscock, E.

10.1101/2021.02.01.429209 — neuroscience — Posted on 2021-02-02

4096 Isolation and in vitro culture of primary pia mater cells

Saadeh, F.; Remsik, J.; Derderian, C.; Chi, Y.; Boire, A.

10.1101/2021.02.01.429222 — neuroscience — Posted on 2021-02-02

4097 CRISPR targeting of MEIOTIC-TOPOISOMERASE VIB-dCas9 to a recombination hotspot is insufficient to increase crossover frequency in Arabidopsis

Yelina, N. E.; Gonzalez-Jorge, S.; Hirsz, D.; Yang, Z.; Henderson, I. R.

10.1101/2021.02.01.429210 — plant biology — Posted on 2021-02-02

4098 Hydrogen peroxide modulates lignin and silica deposits in sorghum roots

Zexer, N.; Elbaum, R.

10.1101/2021.02.01.429181 — plant biology — Posted on 2021-02-02

4099 Differential dropout analysis captures biological variation in single-cell RNA sequencing data

Bouland, G. A.; Mahfouz, A.; Reinders, M. J. T.

10.1101/2021.02.01.429187 — bioinformatics — Posted on 2021-02-02

4100 Image denoising for fluorescence microscopy by self-supervised transfer learning

Wang, Y.; Pinkard, H.; Zhou, S.; Waller, L.; Huang, B.

10.1101/2021.02.01.429188 — bioinformatics — Posted on 2021-02-02

4101 The adaptive value of tandem communication in ants: insights from an agent-based model

Goy, N.; Glaser, S. M.; Grueter, C.

10.1101/2020.09.14.296426 — animal behavior and cognition — Posted on 2021-02-02

4102 Single-nuclei RNA-sequencing of plant tissues

Sunaga-Franze, D. Y.; Muino, J.; Braeuning, C.; Xu, X.; Zong, M.; Smaczniak, C.; Yan, W.; Fischer, C.; Vidal, R.; Kliem, M.; Kaufmann, K.; Sauer, S.

10.1101/2020.11.14.382812 — genomics — Posted on 2021-02-02

4103 Neuronal control of maternal provisioning in response to social cues

Wasson, J. A.; Harris, G.; Keppler-Ross, S.; Brock, T. J.; Dar, A. R.; Butcher, R. A.; Fischer, S. E. J.; Kagias, K.; Clardy, J.; Zhang, Y.; Mango, S. E.

10.1101/2021.02.01.429208 — genetics — Posted on 2021-02-02

4104 Evolution of flowering time in a selfing annual plant: Roles of adaptation and genetic drift

Gay, L.; Dhinaut, J.; Jullien, M.; Vitalis, R.; Navascues, M.; Ranwez, V.; Ronfort, J.

10.1101/2020.08.21.261230 — evolutionary biology — Posted on 2021-02-02

4105 Hybridization enables the fixation of selfish queen genotypes in eusocial colonies

Weyna, A.; Romiguier, J.; Mullon, C. D. L.

10.1101/2021.01.12.426359 — evolutionary biology — Posted on 2021-02-02

4106 Relaxation of purifying selection suggests low effective population size in eusocial Hymenoptera and solitary pollinating bees

Romiguier, J.; Weyna, A.

10.1101/2020.04.14.038893 — evolutionary biology — Posted on 2021-02-02

4107 Climate warming changes synchrony of plants and pollinators

Freimuth, J.; Bossdorf, O.; Scheepens, J. F.; Willems, F. M.

10.1101/2021.01.10.425984 — ecology — Posted on 2021-02-02

4108 The Collagens DPY-17 and SQT-3 Direct Anterior-Posterior Migration of the Q Neuroblasts in C. elegans.

Lang, A. E.; Lundquist, E. A.

10.1101/2021.02.01.429218 — developmental biology — Posted on 2021-02-02

4109 The ATF6β-calreticulin axis protects hippocampal neurons against endoplasmic reticulum stress and excitotoxicity

Nguyen, D. T.; Le, T. M.; Hattori, T.; Takarada-Iemata, M.; Ishii, H.; Roboon, J.; Tamatani, T.; Kannon, T.; Hosomichi, K.; Tajima, A.; Taniuchi, S.; Miyake, M.; Oyadomari, S.; Saito, S.; Mori, K.; Hori, O.

10.1101/2021.02.01.429116 — cell biology — Posted on 2021-02-02

4110 The cyclic di-GMP network is a global regulator of phase-transition and attachment-dependent host colonization in Erwinia amylovora

Kharadi, R. R.; Selbmann, K.; Sundin, G. W.

10.1101/2021.02.01.429191 — microbiology — Posted on 2021-02-02

4111 Immune complex solubility and size govern individual Fc-gamma receptor responses: Novel biomarkers for autoimmune diseases

Chen, H.; Maul-Pavicic, A.; Holzer, M.; Salzer, U.; Chevalier, N.; Voll, R. E.; Hengel, H.; Kolb, P.

10.1101/2020.11.11.378232 — immunology — Posted on 2021-02-02

4112 Microglia control glutamatergic synapses in the adult mouse hippocampus

Basilico, B.; Ferrucci, L.; Ratano, P.; Golia, M. T.; Grimaldi, A.; Rosito, M.; Ferretti, V.; Reverte, I.; Marrone, M. C.; Giubettini, M.; de Turris, V.; Salerno, D.; Garofalo, S.; St-Pierre, M.-K.; Carrier, M.; Renzi, M.; Pagani, F.; Raspa, M.; Scavizzi, F.; Gross, C. T.; Marinelli, S.; Tremblay, M.-E.; Caprioli, D.; Maggi, L.; Limatola, C.; Di Angelantonio, S.; Ragozzino, D.

10.1101/2021.02.01.429096 — neuroscience — Posted on 2021-02-02

4113 Maladaptive cue-controlled cocaine-seeking habits promote increased relapse severity in rats.

Fouyssac, M.; Pena-Oliver, Y.; Puaud, M.; Lim, N.; Giuliano, C.; Everitt, B. J.; Belin, D.

10.1101/2021.02.01.429216 — neuroscience — Posted on 2021-02-02

4114 Glucose-dependent activation, activity, and deactivation of beta cell networks in acute mouse pancreas tissue slices

Stozer, A.; Skelin Klemen, M.; Gosak, M.; Krizancic-Bombek, L.; Pohorec, V.; Slak Rupnik, M.; Dolensek, J.

10.1101/2020.03.11.986893 — physiology — Posted on 2021-02-02

4115 A specific agonist of the orphan nuclear receptor NR2F1 suppresses metastasis through the induction of cancer cell dormancy

10.1101/2021.01.30.428967 — cancer biology — Posted on 2021-02-02

4116 Studying models of balancing selection usingphase-type theory

Zeng, K.; Charlesworth, B.; Hobolth, A.

10.1101/2020.07.06.189837 — evolutionary biology — Posted on 2021-02-02

4117 Neutralization of SARS-CoV-2 VOC 501Y.V2 by human antisera elicited by both inactivated BBIBP-CorV and recombinant dimeric RBD ZF2001 vaccines

Huang, B.; Dai, L.; Wang, H.; Hu, Z.; Tan, W.; Gao, G. F.; Yang, X.

10.1101/2021.02.01.429069 — microbiology — Posted on 2021-02-02

4118 Cortical representation of touch in silico

Huang, C.; Zeldenrust, F.; Celikel, T.

10.1101/2020.11.06.371252 — neuroscience — Posted on 2021-02-02

4119 Cell type specific information transfer for sparse coding

Zeldenrust, F.; Calcini, N.; Yan, X.; Bijlsma, A.; Celikel, T.

10.1101/2020.11.06.371658 — neuroscience — Posted on 2021-02-02

4120 Transparent and flexible ECoG electrode arrays based on silver nanowire networks for neural recordings

Neto, J. P.; Costa, A.; Pinto, J. V.; Marques-Smith, A.; Costa, J.; Martins, R.; Fortunato, E.; Kampff, A. R.; Barquinha, P.

10.1101/2020.02.24.962878 — neuroscience — Posted on 2021-02-02

4121 Efficient CRISPR/Cas9 mutagenesis for neurobehavioral screening in adult zebrafish

Shaw, D. K.; Mokalled, M.

10.1101/2021.02.01.429280 — genetics — Posted on 2021-02-02

4122 Regenerating insulin-producing β-cells ectopically from a mesodermal origin in the absence of endothelial specification

Liu, K.-C.; Villasenor, A.; Schmitner, N.; Radros, N.; Rautio, L.; Reischauer, S.; Stainier, D. Y.; Andersson, O.

10.1101/2021.02.01.429189 — developmental biology — Posted on 2021-02-02

4123 Agricultural fertilization with poultry manure results in persistent environmental contamination with the pathogen Clostridioides difficile

Frentrup, M.; Thiel, N.; Junker, V.; Behrens, W.; Munch, S.; Siller, P.; Kabelitz, T.; Faust, M.; Indra, A.; Baumgartner, S.; Schepanski, K.; Amon, T.; Roesler, U.; Funk, R.; Nubel, U.

10.1101/2021.02.01.429155 — microbiology — Posted on 2021-02-02

4124 Variation in Leishmania chemokine suppression driven by diversification of the GP63 virulence factor

Antonia, A. L.; Martin, A. T.; Wang, L.; Ko, D. C.

10.1101/2021.02.01.429140 — microbiology — Posted on 2021-02-02

4125 Rapid fall in circulating non-classical monocytes in ST elevation myocardial infarction patients correlates with cardiac injury

Marsh, S.; Park, C.; Redgrave, R. E.; Singh, E.; Draganova, L. V.; Boag, S. E.; Spray, L.; Ali, S.; Spyridopoulos, I.; Arthur, H. M.

10.1101/2021.02.01.428825 — immunology — Posted on 2021-02-02

4126 Phase Gradients and Anisotropy of the Suprachiasmatic Network

Yoshikawa, T.; Pauls, S. D.; Foley, N.; Taub, A.; LeSauter, J.; Foley, D.; Honma, K.-I.; Honma, S.; Silver, R.

10.1101/2021.02.01.429173 — neuroscience — Posted on 2021-02-02

4127 Environmental enrichment induces epigenomic and genome organization changes relevant for cognitive function

Espeso-Gil, S.; Holik, A.; Bonnin, S.; Jhanwar, S.; Chandrasekaran, S.; Pique-Regi, R.; Albaiges-Rafols, J.; Maher, M.; Permanyer, J.; Irimia, M.; Friedländer, M. R.; Pons-Espinal, M.; Akbarian, S.; Dierssen, M.; Maass, P. G.; Hor, C. N.; Ossowski, S.

10.1101/2021.01.31.428988 — neuroscience — Posted on 2021-02-02

4128 Complementary Maps for Location and Environmental Structure in CA1 and Subiculum

Olson, J. M.; Johnson, A. B.; Chang, L.; Tao, E. L.; Wang, X.; Nitz, D. A.

10.1101/2021.02.01.428537 — neuroscience — Posted on 2021-02-02

4129 Learning and attention increase visual response selectivity through distinct mechanisms

Poort, J.; Wilmes, K. A.; Blot, A.; Chadwick, A.; Sahani, M.; Clopath, C.; Mrsic-Flogel, T. D.; Hofer, S. B.; Khan, A. G.

10.1101/2021.01.31.429053 — neuroscience — Posted on 2021-02-02

4130 Cubam receptor-mediated endocytosis in hindgut-derived pseudoplacenta of a viviparous teleost Xenotoca eiseni

Iida, A.; Sano, K.; Inokuchi, M.; Suzuki, T.; Kuriki, M.; Sogabe, M.; Susaki, D.; Tonosaki, K.; Kinoshita, T.; Hondo, E.

10.1101/2021.02.01.429082 — zoology — Posted on 2021-02-02

4131 Contextualization of causal regulatory networks from toxicogenomics data applied to drug-induced liver injury

Trairatphisan, P.; de Souza, T. M.; Kleinjans, J.; Jennen, D.; Saez-Rodriguez, J.

10.1101/2021.01.31.429025 — systems biology — Posted on 2021-02-02

4132 The Reactobiome Unravels a New Paradigm in Human Gut Microbiome Metabolism

Bidkhori, G.; Lee, S.; Edwards, L.; Chatelier, E. L.; Almeida, M.; Ezzamouri, B.; Plaza -Onate, F.; Ponte, N.; Shawcross, D.; Proctor, G. B.; Nielsen, L.; Nielsen, J.; Uhlen, M.; Dusko Ehrlich, S.; Shoaie, S.

10.1101/2021.02.01.428114 — systems biology — Posted on 2021-02-02

4133 ESD1 Affects Seed Setting Rate in Rice by Controlling Embryo Sac Development

Wang, T.; Li, Y.; Song, S.; Qiu, M.; Zhang, L.; Li, C.; Dong, H.; Li, L.; Wang, J.; Li, L.

10.1101/2021.02.01.429182 — plant biology — Posted on 2021-02-02

4134 Tomato roots sense horizontal/vertical mechanical impedance and divergently modulate root/shoot metabolome

Kumari, A.; Nongmaithem, S.; Devulapalli, S.; Sreelakshmi, Y.; Sharma, R.

10.1101/2021.02.01.429093 — plant biology — Posted on 2021-02-02

4135 Stimulated oxygen transport in tissue by magnetic needles - Physiology of acupuncture

Liu, Z.; Wen, C.; Zhang, S.

10.1101/2021.02.01.426016 — physiology — Posted on 2021-02-02

4136 Evidence for efficient non-evaporative leaf-to-air heat dissipation in a pine forest under drought conditions

Muller, J. D.; Rotenberg, E.; Tatarinov, F.; Oz, I.; Yakir, D.

10.1101/2021.02.01.429145 — physiology — Posted on 2021-02-02

4137 Electrospun fibers for vaginal administration of tenofovir disoproxil fumarate and emtricitabine in the context of topical pre-exposure prophylaxis

Nunes, R.; Bogas, S.; Faria, M. J.; Goncalves, H.; Lucio, M.; Viseu, T.; Sarmento, B.; das Neves, J.

10.1101/2021.02.01.429162 — pharmacology and toxicology — Posted on 2021-02-02

4138 PACAS: pairwise comparisons of aligned subsequences

DeMonn, K.; Powell, C. L. E.; Battistuzzi, F. U.

10.1101/2021.02.01.428731 — bioinformatics — Posted on 2021-02-02

4139 A Reproducibility Analysis-based Statistical Framework for Residue-Residue Evolutionary Coupling Detection

Si, Y.; Yan, C.

10.1101/2021.02.01.429092 — bioinformatics — Posted on 2021-02-02

4140 A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease risk

Macdonald-Dunlop, E.; Taba, N.; Klaric, L.; Frkatovic, A.; Walker, R.; Hayward, C.; Esko, T.; Haley, C.; Fischer, K.; Wilson, J. F.; Joshi, P. K.

10.1101/2021.02.01.429117 — bioinformatics — Posted on 2021-02-02

4141 LoopViz: A uLoop Assembly Clone Verification Tool for Nanopore Sequencing Reads

Lensink, M. E.; Abramson, B.; Hartwick, N.; Poire, A.; Bielinski, V. A.; Michael, T.

10.1101/2021.02.01.427927 — bioinformatics — Posted on 2021-02-02

4142 Video-based quantification of human movement frequency using pose estimation

Cornman, H. L.; Stenum, J.; Roemmich, R. T.

10.1101/2021.02.01.429161 — bioengineering — Posted on 2021-02-02

4143 Single-component optogenetic tools for inducible RhoA GTPase signaling

Berlew, E. E.; Kuznetsov, I. A.; Yamada, K. K.; Bugaj, L. J.; Boerckel, J. D.; Chow, B. Y.

10.1101/2021.02.01.429147 — bioengineering — Posted on 2021-02-02

4144 Consequences of the Nyquist-Shannon sampling criterion in Mesoscopic Multiphoton Microscopy to avail full-field sub-micron resolution resolvability

Borah, B. J.; Lee, J.-C.; Chi, H.-H.; Hsiao, Y.-T.; Yen, C.-T.; Sun, C.-K.

10.1101/2021.01.31.429063 — bioengineering — Posted on 2021-02-02

4145 Comparative genomics of Chinese and international isolates of Escherichia albertii: population structure and evolution of virulence and antimicrobial resistance

Luo, L.; Wang, H.; Payne, M. J.; Liang, C.; Bai, L.; Zheng, H.; Zhang, Z.; Zhang, L.; Zhang, X.; Yan, G.; Zou, N.; Chen, X.; Wan, Z.; Xiong, Y.; Lan, R.; Li, Q.

10.1101/2021.02.01.429068 — genomics — Posted on 2021-02-02

4146 Selfish migrants: How a meiotic driver is selected to increase dispersal

Runge, J.-N.; Kokko, H.; Lindholm, A. K.

10.1101/2021.02.01.429134 — evolutionary biology — Posted on 2021-02-02

4147 Hybridization dynamics and extensive introgression in the Daphnia longispina species complex: new insights from a high-quality Daphnia galeata reference genome

Nickel, J. H.; Schell, T.; Holtzem, T.; Thielsch, A.; Dennis, S. R.; Schlick-Steiner, B.; Steiner, F. M.; Moest, M.; Pfenninger, M.; Schwenk, K.; Cordellier, M.

10.1101/2021.02.01.429177 — evolutionary biology — Posted on 2021-02-02

4148 The evolution of the metazoan Toll receptor family and its expression during protostome development

Orus, A.; Lu, T.-M.; Hejnol, A.

10.1101/2021.02.01.429095 — evolutionary biology — Posted on 2021-02-02

4149 Stochastic dynamics of consumer-resource interactions

Singh, A.

10.1101/2021.02.01.429174 — ecology — Posted on 2021-02-02

4150 Spatial integrated models foster complementarity between monitoring programs in producing large-scale ecological indicators

Lauret, V.; Labach, H.; Turek, D.; Laran, S.; Gimenez, O.

10.1101/2021.02.01.429097 — ecology — Posted on 2021-02-02

4151 How animals endure by bending environmental space: Redefining the fundamental niche

Matthiopoulos, J.

10.1101/2021.02.01.429132 — ecology — Posted on 2021-02-02

4152 Risk assessment for the establishment of the Asian giant hornet (Vespa mandarinia) in the Pacific Northwest

Norderud, E. D.; Powell, S. L.; Peterson, R. K. D.

10.1101/2021.02.01.429186 — ecology — Posted on 2021-02-02

4153 Faecal metabarcoding reveals pervasive long-distance impacts of garden bird feeding

Shutt, J. D.; Trivedi, U. H.; Nicholls, J. A.

10.1101/2021.01.31.429015 — ecology — Posted on 2021-02-02

4154 The carbon footprint of meat and dairy proteins: a practical perspective to guide low carbon footprint dietary choices

Marbach, S.; Gaillac, R.

10.1101/2021.01.31.429047 — ecology — Posted on 2021-02-02

4155 MESOMELIC DYSPLASIAS ASSOCIATED WITH THE HOXD LOCUS ARE CAUSED BY REGULATORY REALLOCATIONS

Bolt, C. C.; Lopez-Delisle, L.; Mascrez, B.; Duboule, D.

10.1101/2021.02.01.429171 — developmental biology — Posted on 2021-02-02

4156 Long noncoding RNA VENTHEART is required for cardiomyocyte specification and function

Foo, R.; Dashi, A.; Lek Wen, T. W.; Anene, G.; Pan, b.; Autio, M. I.; Tiang, Z.; Hartman, R.; Stenzig, J.; Wei, H.; Chen, G.; Ackers-Johnson, M.; Jonsson, M.; Walentinsson, A.; Lim, B.; Iyer, V.

10.1101/2021.02.01.429136 — cell biology — Posted on 2021-02-02

4157 Mouse oocytes do not contain a conventional Balbiani body

Dhandapani, L.; Salzer, M.; Duran, J. M.; Zaffagnini, G.; De Guirior, C.; Martinez-Zamora, M. A.; Boke, E.

10.1101/2021.02.01.429160 — cell biology — Posted on 2021-02-02

4158 EMC is required for biogenesis and membrane insertion of Xport-A, an essential chaperone of rhodopsin-1 and the TRP channel

Gaspar, C. J.; Vieira, L. C.; Christianson, J. C.; Jakubec, D.; Strisovsky, K.; Adrain, C.; Domingos, P.

10.1101/2021.02.01.429115 — cell biology — Posted on 2021-02-02

4159 Molecular mechanism behind the involvement of apple flavonoid glycosyltransferase gene MdGT1 in the color of apple leaves

Li, P.; Ge, H.; Zhang, L.; Shu, J.; Sun, Z.; Jiang, L.; Zheng, C.-C.; Shu, H.; Sha, G.; Ji, L.; Zhang, S.

10.1101/2021.02.01.429094 — molecular biology — Posted on 2021-02-02

4160 Synapomorphic variations in the THAP domains of the human THAP protein family and its homologs

Sanghavi, H. M. K.; Majumdar, S.

10.1101/2021.02.01.429122 — molecular biology — Posted on 2021-02-02

4161 LncRNA XIST knockdown suppresses cell proliferation and promotes apoptosis in diabetic cataract via miR-34a/SMAD2 axis

Wang, C.; Zhao, R.; Zhang, S.

10.1101/2021.02.01.429101 — microbiology — Posted on 2021-02-02

4162 Heliorhodopsin evolution is driven by photosensory promiscuity in monoderms

Bulzu, P.-A.; Kavagutti, V. S.; Chiriac, M.-C.; Vavourakis, C.; Inoue, K.; Kandori, H.; Andrei, A.-S.; Ghai, R.

10.1101/2021.02.01.429150 — microbiology — Posted on 2021-02-02

4163 Itaconate and fumarate derivatives exert a dual inhibitory effect on canonical NLRP3 activation in macrophages and microglia

Hoyle, C.; Green, J. P.; Allan, S. M.; Brough, D.; Lemarchand, E.

10.1101/2021.02.01.429180 — immunology — Posted on 2021-02-02

4164 Quality control strategies for brain MRI segmentation and parcellation: practical approaches and recommendations - insights from The Maastricht Study

Monereo Sanchez, J.; de Jong, J.; Drenthen, G.; Beran, M.; Backes, W.; Stehouwer, C.; Schram, M.; Linden, D.; Jansen, J.

10.1101/2021.02.01.428681 — neuroscience — Posted on 2021-02-02

4165 The beta component of gamma-band auditory steady-state responses in patients with schizophrenia

Metzner, C.; Steuber, V.

10.1101/2021.02.01.429120 — neuroscience — Posted on 2021-02-02

4166 Preparatory activity links frontal eye field activity with small amplitude motor unit recruitment of neck muscles during gaze planning

Rungta, S. P.; Basu, D.; Sendhilnathan, N.; Murthy, A.

10.1101/2021.02.01.429125 — neuroscience — Posted on 2021-02-02

4167 Increasing age is independently associated with higher free water in non-active MS brain - A multi-compartment analysis using FAST-T2

Zhou, L.; Li, Y.; Wang, X. H.; Sweeney, E.; Zhang, H.; Tanzi, E. B.; Prince, J.; Su-Ortiz, V. A.; Gauthier, S. A.; Nguyen, T. D.

10.1101/2021.02.01.429067 — neuroscience — Posted on 2021-02-02

4168 A deep network-based model of hippocampal memory functions under normal and Alzheimer's disease conditions

Kanagamani, T.; Chakaravarthy, V. S.; Ravindran, B.

10.1101/2021.01.31.429076 — neuroscience — Posted on 2021-02-02

4169 Properties of multi-vesicular release from rod photoreceptors support transmission of single photon responses

Hays, C. L.; Field, G. D.; Thoreson, W.

10.1101/2021.02.01.429179 — neuroscience — Posted on 2021-02-02

4170 Transcriptomics-informed large-scale cortical model captures topography of pharmacological neuroimaging effects of LSD

Burt, J. B.; Preller, K. H.; Demirtas, M.; Ji, J. L.; Krystal, J. H.; Vollenweider, F. X.; Anticevic, A.; Murray, J. D.

10.1101/2021.01.31.429016 — neuroscience — Posted on 2021-02-02

4171 Motor cortex activity across movement speeds is predicted by network-level strategies for generating muscle activity

Saxena, S.; Russo, A.; Cunningham, J.; Churchland, M. M.

10.1101/2021.02.01.429168 — neuroscience — Posted on 2021-02-02

4172 Differential activation of parathyroid and renal Ca2+-sensing receptors underlies the renal phenotype in autosomal dominant hypocalcemia 1

van Megen, W.; Tan, R.; Alexander, R. T.; Dimke, H.

10.1101/2021.02.01.429170 — physiology — Posted on 2021-02-02

4173 Metabolomic profiling of pancreatic adenocarcinoma reveals fundamental clinical features

IOVANNA, J. L.; El kaoutari, A.; Fraunhoffer, N.; Hoare, O.; Teyssedou, C.; Gayet, O.; Roques, J.; Lomberk, G. A.; Urrutia, R. A.; Dusetti, N. J.

10.1101/2021.02.01.429087 — cancer biology — Posted on 2021-02-02

4174 Cannabinoids is a "No-Go" While a Cancer Patient is on Immunotherapy; but is It Safe to Use Psychedelics During Cancer Immunotherapy?

Amit Romach, E.; Nachliely, M.; Moran, O.; Brami, M.; Lamensdorf, I.

10.1101/2021.02.01.429102 — cancer biology — Posted on 2021-02-02

4175 Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer

Delaine-Smith, R.; Maniati, E.; Malacrida, B.; Nichols, S.; Roozitalab, R.; Jones, R. R.; Lecker, L.; Pearce, O. M.; Knight, M. M.; Balkwill, F. R.

10.1101/2021.02.01.428374 — cancer biology — Posted on 2021-02-02

4176 The Prognostic Value of Tumor-Infiltrating Immune Cells in Gynecologic Cancers

Chen, W.; Hu, T.; He, C.

10.1101/2021.01.31.429066 — cancer biology — Posted on 2021-02-02

4177 Catechin complexed with lysine has potent antitumor activities in human breast cancer xenograft model

Katsoulieris, E. N.; Rodriguez, A. C.

10.1101/2021.02.01.429090 — cancer biology — Posted on 2021-02-02

4178 Targeted therapy for LIMD1-deficient non-small cell lung cancer subtypes.

Davidson, K.; Grevitt, P.; Contreras, M.; Bridge, K. S.; Hermida, M.; Shah, K. M.; Mardakheh, F. K.; Stubbs, M.; Clarke, P. A.; Burke, R.; Casado-Izquierdo, P.; Cutillas, P. R.; Martin, S. A.; Sharp, T. V.

10.1101/2021.02.01.429178 — cancer biology — Posted on 2021-02-02

4179 Machine learning based cellular contractile force detection: a new approach to predict cell mechanics by images

Li, H.; Matsunaga, D.; Matsui, T. S.; Aosaki, H.; Inoue, K.; Doostmohammadi, A.; Deguchi, S.

10.1101/2021.02.01.429065 — biophysics — Posted on 2021-02-01

4180 Associations of weather fronts with pig reproduction and mortality

Reibling, T.; Hagstrand, L.; Maroti-Agots, A.; Barcza, Z.; Solymosi, N.

10.1101/2021.02.01.428991 — biophysics — Posted on 2021-02-02

4181 OmicsTIDE: Interactive Exploration of Trends in Multi-Omics Data

Harbig, T. A.; Fratte, J.; Krone, M.; Nieselt, K. K.

10.1101/2021.02.01.428836 — bioinformatics — Posted on 2021-02-02

4182 DRDOCK: A Drug Repurposing platform integrating automated docking, simulations and a log-odds-based drug ranking scheme

Tsai, K.-L.; Yang, L.-W.

10.1101/2021.01.31.429052 — bioinformatics — Posted on 2021-02-02

4183 Telomere maintenance pathway activity analysis enables tissue- and gene-level inferences

Nersisyan, L.; Simonyan, A.; Binder, H.; Arakelyan, A.

10.1101/2021.02.01.429081 — bioinformatics — Posted on 2021-02-02

4184 Meta-Analysis of Oxidative Transcriptomes in Insects

Bono, H.

10.1101/2021.02.01.427354 — bioinformatics — Posted on 2021-02-02

4185 Synthetic Antigen-Presenting Cells for Adoptive T Cell Therapy

Dahotre, S. N.; Romanov, A. M.; Su, F.-Y.; Kwong, G. A.

10.1101/2021.02.01.429167 — bioengineering — Posted on 2021-02-02

4186 Molecular basis for two stereoselective Diels-Alderases that produce decalin skeletons

Fujiyama, K.; Kato, N.; Re, S.; Kinugasa, K.; Watanabe, K.; Takita, R.; Nogawa, T.; Hino, T.; Osada, H.; Sugita, Y.; Takahashi, S.; Nagano, S.

10.1101/2021.02.01.429105 — biochemistry — Posted on 2021-02-02

4187 MDA5 autoimmune disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA

Yu, Q.; Herrero del Valle, A.; Singh, R.; Modis, Y.

10.1101/2021.02.01.429133 — biochemistry — Posted on 2021-02-02

4188 Genomic Considerations for FHIR; eMERGE Implementation Lessons

Murugan, M.; Babb, L. J.; Taylor, C. O.; Rasmussen, L. V.; Freimuth, R. R.; Venner, E.; Yan, F.; Yi, V.; Granite, S. J.; Zouk, H.; Aronson, S. J.; Power, K.; Fedotov, A.; Crosslin, D. R.; Fasel, D.; Jarvik, G. P.; Hakonarson, H.; Bangash, H.; Kullo, I. J.; Connolly, J. J.; Nestor, J. G.; Caraballo, P. J.; Wei, W.; Wiley, K.; Rehm, H. L.; Gibbs, R. A.

10.1101/2021.01.31.429037 — genomics — Posted on 2021-02-01

4189 TRIM71 deficiency causes germ cell loss during mouse embryogenesis and promotes human male infertility

Torres-Fernández, L. A.; Emich, J.; Port, Y.; Mitschka, S.; Wöste, M.; Schneider, S.; Fietz, D.; Oud, M. S.; Di Persio, S.; Neuhaus, N.; Kliesch, S.; Hölzel, M.; Schorle, H.; Friedrich, C.; Tüttelmann, F.; Kolanus, W.

10.1101/2021.02.01.429172 — developmental biology — Posted on 2021-02-02

4190 Identification of Pectobacterium species isolated from the soft rot of tetecho (Neobuxbaumia tetetzo), a columnar cactus, and associated metagenomics

Vargas-Peralta, D.; Narvaez-Barragan, D.; De Sandozequi, A.; Segovia, L.; Martinez-Anaya, C.; Romero-Gutierrez, M.; David Alcaraz, L.; De la Torre Almaraz, R.

10.1101/2021.02.01.429127 — microbiology — Posted on 2021-02-01

4191 Task-specific elevation of motor learning by conjunctive transcranial direct current stimulation

Wang, Y.; Wang, J.-x.; Zhang, Q.-f.; Xiao, K.-w.; Wang, L.; Yu, Q.-p.; Xie, Q.; Poo, M.-m.; Wen, Y.

10.1101/2021.01.31.429080 — neuroscience — Posted on 2021-02-02

4192 In-land long-term culture of colonial ascidians

Wawrzyniak, M. K.; Matas Serrato, L. A.; Blanchoud, S.

10.1101/2021.01.31.429038 — zoology — Posted on 2021-02-01

4193 Energy content of anchovy and sardine using surrogate calorimetry methods

Campanini, C.; Albo-Puigserver, M.; Gerez, S.; Lloret-Lloret, E.; Gimenez, J.; Pennino, M. G.; Bellido, J. M.; Colmenero, A. I.; Coll, M.

10.1101/2021.02.01.429042 — physiology — Posted on 2021-02-01

4194 Protein SUMOylation is crucial for phagocytosis in Entamoeba histolytica trophozoites

Diaz-Hernandez, M.; Javier-Reyna, R.; Ortega-Soto, I.; Garcia-Rivera, G.; Montano, S.; Betanzos, A.; Orozco, E.

10.1101/2021.02.01.429131 — microbiology — Posted on 2021-02-01

4195 Non-Canonical Projections from Ventral CA1 and Subicular Complex to CA3 Augments the Feedforward Hippocampal Trisynaptic Pathway

Lin, X.; Amarlraj, M.; Blanton, C.; Avila, B.; Todd, H.; Nitz, D.; Xu, X.

10.1101/2021.02.01.429124 — neuroscience — Posted on 2021-02-01

4196 Hierarchical modelling of functional brain networks in population and individuals from big fMRI data

Farahibozorg, S.-R.; Bijsterbosch, J. D.; Gong, W.; Jbabdi, S.; Smith, S. M.; Harrison, S. J.; Woolrich, M. W.

10.1101/2021.02.01.428496 — neuroscience — Posted on 2021-02-01

4197 Geometry of neural computation unifies working memory and planning

Ehrlich, D. B.; Murray, J. D.

10.1101/2021.02.01.429156 — neuroscience — Posted on 2021-02-01

4198 Input-independent homeostasis of developing thalamocortical activity

Riyahi, P.; Phillips, M. A.; Colonnese, M. T.

10.1101/2021.02.01.429056 — neuroscience — Posted on 2021-02-01

4199 Sablefish (Anoplopoma fimbria) plasma biochemistry and hematology reference intervals including blood cell morphology

Schubiger, C.; Gorman, M. E.; Johns, J. L.; Arkoosh, M. R.; Dietrich, J. P.

10.1101/2021.02.01.429130 — zoology — Posted on 2021-02-01

4200 Terpenoid components, antioxidant and antibacterial activities of essential oils from fresh immature and mature leaves of Blumea balsamifera, extracted with different hydrodistillation periods

Jirakitticharoen, S.; Wisuitiprot, W.; Jitareerat, P.; Wongs-Aree, C.

10.1101/2021.02.01.429126 — plant biology — Posted on 2021-02-01

4201 Development and validation of a cellular host response test as an early diagnostic for sepsis

Guillou, L.; Sheybani, R.; Jensen, A. E.; DiCarlo, D.; Caffery, T.; Thomas, C. B.; Shah, A. M.; Tse, H. T. K.; O'Neal, H. R.

10.1101/2021.02.01.429128 — bioengineering — Posted on 2021-02-01

4202 Verapamil/Curcumin treatment attenuates the behavioral alterations observed in Williams Syndrome mice by regulation of MAPK pathway and Microglia overexpression

Ortiz-Romero, P.; Egea, G.; Perez-Jurado, L. A.; Campuzano, V.

10.1101/2021.02.01.429086 — animal behavior and cognition — Posted on 2021-02-01

4203 A functional bacterial-derived restriction modification system in the mitochondrion of a heterotrophic protist

Milner, D.; Wideman, J.; Stairs, C.; Dunn, C.; Richards, T. A.

10.1101/2021.02.01.429123 — evolutionary biology — Posted on 2021-02-01

4204 Structural analysis of viral ExoN domains reveals polyphyletic hijacking events

Cruz-Gonzalez, A.; Munoz-Velasco, I.; Cottom-Salas, W.; Becerra, A.; Campillo-Balderas, J. A.; Hernandez-Morales, R.; Vazquez-Salazar, A.; Jacome, R.; Lazcano, A.

10.1101/2021.02.01.429129 — evolutionary biology — Posted on 2021-02-01

4205 Spindle-slow oscillation coupling during sleep predicts sequence-based language learning

Cross, Z. R.; Helfrich, R. F.; Kohler, M. J.; Corcoran, A. W.; Coussens, S.; Zou-Williams, L.; Schlesewsky, M.; Gaskell, M. G.; Knight, R. T.; Bornkessel-Schlesewsky, I.

10.1101/2020.02.13.948539 — neuroscience — Posted on 2021-02-01

4206 Feature-based Quality Assessment of Middle Cerebral Artery Occlusion Using 18F-fluorodeoxyglucose Positron Emission Tomography

He, W.; Tang, H.; Li, J.; Hou, C.; Shen, X.; Li, C.; Liu, H.; Yu, W.

10.1101/2020.12.28.424532 — neuroscience — Posted on 2021-02-01

4207 Early, color-specific neural responses to object color knowledge

Retter, T. L.; Gao, Y.; Jiang, F.; Rossion, B.; Webster, M. A.

10.1101/2021.02.01.429104 — neuroscience — Posted on 2021-02-01

4208 Deciphering active prophages from metagenomes

Kieft, K.; Anantharaman, K.

10.1101/2021.01.29.428894 — bioinformatics — Posted on 2021-02-01

4209 A Fast Lasso-based Method for Inferring Pairwise Interactions

Elmes, K.; Heywood, A.; Huang, Z.; Gavryushkin, A.

10.1101/2021.01.28.428698 — bioinformatics — Posted on 2021-02-01

4210 Resequencing 250 soybean accessions: new insights into genes associated with agronomic traits and genetic networks

Yang, C.; Yan, J.; Jiang, S.; Li, X.; Min, H.; Wang, X.; Hao, D.

10.1101/2021.01.28.428693 — genomics — Posted on 2021-02-01

4211 The Giardia lamellipodium-like ventrolateral flange supports attachment and rapid cytokinesis

Hardin, W. R.; Alas, G. C. M.; Taparia, N.; Thomas, E. B.; Steele-Ogus, M.; Hvorecny, K. L.; Halpern, A. R.; Tumova, P.; Kollman, J. M.; Vaughan, J. C.; Sniadecki, N. J.; Paredez, A. R.

10.1101/2021.01.31.429041 — cell biology — Posted on 2021-02-01

4212 Cluster-specific gene markers enhance Shigella and Enteroinvasive Escherichia coli in silico serotyping

Zhang, X.; Payne, M.; Nguyen, T.; Kaur, S.; Lan, R.

10.1101/2021.01.30.428723 — microbiology — Posted on 2021-02-01

4213 Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in mice

Boast, B.; Helian, K.; Andrews, D.; Li, X.; Cho, V.; Closa, A.; Sutton, H. J.; Reed, J. H.; Bergmann, H.; Roots, C. M.; Yabas, M.; Barthel, N.; Omari, S. A.; Young, C.; Miosge, L. A.; Eyras, E.; Nutt, S. L.; Hein, N.; Hannan, K. M.; Cockburn, I. A.; Goodnow, C. C.; Enders, A.

10.1101/2021.01.29.428877 — immunology — Posted on 2021-02-01

4214 The secreted peptide IRP functions as a DAMP in rice immunity

Wang, P.; Jia, H.; Guo, T.; Zhang, Y.; Li, Z.; Kawano, Y.

10.1101/2021.01.31.429004 — plant biology — Posted on 2021-02-01

4215 Protein model accuracy estimation empowered by deep learning and inter-residue distance prediction in CASP14

Chen, X.; Liu, J.; Guo, Z.; Wu, T.; Hou, J.; Cheng, J.

10.1101/2021.01.31.428975 — bioinformatics — Posted on 2021-02-01

4216 Host PDZ-containing proteins targeted by SARS-Cov-2

Caillet-Saguy, C.; Durbesson, F.; REZELJ, V. V.; Gogl, G.; Tran, Q. D.; Twizere, J.-C.; Vignuzzi, M.; Vincentelli, R.; Wolff, N.

10.1101/2021.02.01.429176 — biochemistry — Posted on 2021-02-01

4217 Fitting drift-diffusion decision models to trial-by-trial data

Feltgen, Q.; Daunizeau, J.

10.1101/2020.01.30.925123 — animal behavior and cognition — Posted on 2021-02-01

4218 Drosophila functional screening of de novo variants in autism uncovers deleterious variants and facilitates discovery of rare neurodevelopmental diseases

Marcogliese, P. C.; Deal, S. L.; Andrews, J.; Harnish, J. M.; Bhavana, V. H.; Graves, H. K.; Jangam, S.; Luo, X.; Liu, N.; Bei, D.; Chao, Y.-H.; Hull, B.; Lee, P.-T.; Pan, H.; Longley, C. M.; Chao, H.-T.; Chung, H.; Haelterman, N. A.; Kanca, O.; Manivannan, S. N.; Rossetti, L. Z.; Gerard, A.; Schwaibold, E. M. C.; Guerrini, R.; Vetro, A.; England, E.; Murali, C. N.; Barakat, T. S.; van Dooren, M. F.; Wilke, M.; van Slegtenhorst, M.; Lesca, G.; Sabatier, I.; Chatron, N.; Brownstein, C. A.; Madden, J. A.; Agrawal, P. B.; Keller, R.; Pavinato, L.; Brusco, A.; Rosenfeld, J. A.; Marom, R.; Wangler,

10.1101/2020.12.30.424813 — genetics — Posted on 2021-02-01

4219 Territory-level temperature influences settlement decisions, breeding phenology and productivity in three forest passerine birds

Shutt, J. D.; Bell, S. C.; Bell, F.; Castello, J.; El Harouchi, M.; Burgess, M. D.

10.1101/2021.01.31.429009 — ecology — Posted on 2021-02-01

4220 β-importins Tnpo-SR and Cadmus and the small GTPase Ran promote ovarian cyst formation in Drosophila

Beachum, A. N.; Hinnant, T. D.; Williams, A. E.; Powell, A. M.; Ables, E. T.

10.1101/2021.01.31.429051 — developmental biology — Posted on 2021-02-01

4221 H3K4 Methylation in β-cells Prevents Transcriptional Downregulation and Variance Associated with Type 2 Diabetes

Vanderkruk, B.; Maeshima, N.; Pasula, D. J.; An, M.; Suresh, P.; Daniel, A.; McDonald, C. L.; Luciani, D. S.; Hoffman, B.

10.1101/2021.01.28.428651 — cell biology — Posted on 2021-02-01

4222 In vitro inactivation of SARS-CoV-2 with 0.5% povidone iodine nasal spray (Nasodine) at clinically relevant concentrations and timeframes using tissue culture and PCR based assays

Tucker, S. P.; Goodall, S.; Molloy, P.; Julander, J.; Mendenhall, M.; Friedland, P.

10.1101/2021.01.31.426979 — microbiology — Posted on 2021-02-01

4223 Virus-derived peptide inhibitors of the herpes simplex virus type 1 nuclear egress complex

Draganova, E. B.; Heldwein, E. E.

10.1101/2020.06.24.168898 — microbiology — Posted on 2021-02-01

4224 First isolation and genetic characterization of Puumala orthohantavirus strains from France

Vulin, J.; Murri, S.; Madrieres, S.; Galan, M.; Tatard, C.; Piry, S.; Vaccari, G.; D'agostino, C.; Charbonnel, N.; Castel, G.; Marianneau, P.

10.1101/2020.08.27.270181 — microbiology — Posted on 2021-02-01

4225 CXCR6 enforced retention promotes resident memory CD8 T cell-mediated immunosurveillance and control of ovarian cancer.

Muthuswamy, R.; McGray, A. R.; Battaglia, S.; He, W.; Miliotto, A.; Eppolito, C. A.; Litchy, B. D.; Shrikant, P.; Odunsi, K.; Odunsi, K.

10.1101/2020.12.02.401729 — immunology — Posted on 2021-02-01

4226 Paradoxical stabilization of relative position in moving frames

Özkan, M.; Anstis, S.; 't Hart, B. M.; Wexler, M.; Cavanagh, P.

10.1101/2021.01.23.427924 — neuroscience — Posted on 2021-02-01

4227 The Contribution of Environmental Enrichment to Phenotypic Variation in Mice and Rats

Kentner, A. C.; Speno, A. V.; Doucette, J.; Roderick, R. C.

10.1101/2020.07.11.198705 — neuroscience — Posted on 2021-02-01

4228 Asymmetric Binomial Statistics Explains Organelle Partitioning Variance in Cancer Cell Proliferation

Peruzzi, G.; Miotto, M.; Maggio, R.; Ruocco, G.; Gosti, G.

10.1101/2021.01.21.427596 — systems biology — Posted on 2021-02-01

4229 Multiplexed activation in mammalian cells using dFnCas12a-VPR

Bryson, J. W.; Auxillos, J. Y.; Rosser, S.

10.1101/2021.01.31.429049 — synthetic biology — Posted on 2021-02-01

4230 Hedgehog pathway inhibitors significantly reduce the formation of heterotopic ossification in a direct trauma/burn mouse model

Chakraborty, A.; Gvozdenovic-Jeremic, J.; Wang, F.; Hoag, S. W.; Vert-Wong, E.; Pearson, R. M.

10.1101/2021.01.31.429058 — pharmacology and toxicology — Posted on 2021-02-01

4231 Inhalable textile microplastic fibers impair airway epithelial growth

van Dijk, F.; Song, S. S.; van Eck, G.; Wu, X. H.; Bos, S.; Boom, D.; Kooter, I.; Spierings, D. C. J. N.; Wardenaar, R.; Cole, M.; Salvati, A.; Gosens, R.; Melgert, B. N.

10.1101/2021.01.25.428144 — pharmacology and toxicology — Posted on 2021-02-01

4232 Evolution of a virus-like architecture and packaging mechanism in a repurposed bacterial protein

Tetter, S.; Terasaka, N.; Steinauer, A.; Bingham, R. J.; Clark, S.; Scott, A. J. P.; Patel, N.; Leibundgut, M.; Wroblewski, E.; Ban, N.; Stockley, P. G.; Twarock, R.; Hilvert, D.

10.1101/2020.12.23.423990 — biochemistry — Posted on 2021-02-01

4233 Diagnostic design with machine learning model-based optimization

Metsky, H. C.; Welch, N. L.; Haradhvala, N. J.; Rumker, L.; Zhang, Y. B.; Pillai, P. P.; Yang, D. K.; Ackerman, C. M.; Weller, J.; Blainey, P. C.; Myhrvold, C.; Mitzenmacher, M.; Sabeti, P. C.

10.1101/2020.11.28.401877 — genomics — Posted on 2021-02-01

4234 A topological characterization of DNA sequences based on chaos geometry and persistent homology

Nguyen, D. Q. N.; Le, P. D. T.; Xing, L.; Lin, L.

10.1101/2021.01.31.429071 — genomics — Posted on 2021-02-01

4235 Flight demand and environmental niche are associated with molecular evolutionary rates in a large avian radiation

Duchene, D. A.; Montoya, P.; Claramunt, S.; Cadena, D. A.

10.1101/2020.01.16.908368 — evolutionary biology — Posted on 2021-02-01

4236 Genome evolution in an agricultural pest following adoption of transgenic crops

Fritz, M. L.; Hamby, K. A.; Taylor, K.; DeYonke, A. M.; Gould, F.

10.1101/2020.10.05.326801 — evolutionary biology — Posted on 2021-02-01

4237 A pragmatic approach to make theoretical syntheses in ecology

Travassos-Britto, B.; Pardini, R.; El-Hani, C.; Prado, P. I.

10.1101/344200 — ecology — Posted on 2021-02-01

4238 Isolating and Cryo-Preserving Pig Skin Cells for Single Cell RNA Sequencing Study

Han, L.; Jara, C. P.; Wang, O.; Thibivilliers, S.; Woycicki, R. K.; Carlson, M. A.; Velander, W. H.; Araujo, E. P.; Libault, M.; Zhang, C.; Lei, Y.

10.1101/2021.01.31.429035 — cell biology — Posted on 2021-02-01

4239 Regulatory Modules of Human Thermogenic Adipocytes: Functional Genomics of Meta-Analyses Derived Marker-Genes

B. Toth, B.; Barta, Z.; Fesus, L.

10.1101/2021.01.25.428057 — molecular biology — Posted on 2021-02-01

4240 An unusual aspartic acid cluster in the reovirus attachment fiber σ1 mediates stability at low pH

Glorani, G.; Ruwolt, M.; Holton, N.; Neu, U.

10.1101/2021.02.01.429088 — microbiology — Posted on 2021-02-01

4241 Half-life of biodegradable plastics in the marine environment depends on material, habitat, and climate zone

Lott, C.; Eich, A.; Makarow, D.; Unger, B.; van Eekert, M.; Schuman, E.; Segre Reinach, M.; Lasut, M. T.; Weber, M.

10.1101/2021.01.31.429013 — microbiology — Posted on 2021-02-01

4242 Nonameric structures of the cytoplasmic domain of FlhA and SctV in the context of the full-length protein

Kuhlen, L.; Johnson, S.; Cao, J. Y.; Deme, J.; Lea, S. M.

10.1101/2020.10.12.336966 — microbiology — Posted on 2021-02-01

4243 Diet-regulated production of PDGFcc by macrophages controls energy storage

Cox, N.; Crozet, L.; Holtman, I. R.; Loyher, P.-L.; Lazarov, T.; Mass, E.; Stanley, R.; Glass, C. K.; Geissmann, F.

10.1101/2020.06.15.152397 — immunology — Posted on 2021-02-01

4244 The Drosophila Baramicin polypeptide gene protects against fungal infection

Hanson, M. A.; Cohen, L. B.; Marra, A.; Iatsenko, I.; Wasserman, S. A.; Lemaitre, B.

10.1101/2020.11.23.394148 — immunology — Posted on 2021-02-01

4245 Neuronal morphology and physiology, functional brain networks and memory in temporal lobe epilepsy

Douw, L.; Nissen, I. A.; Fitzsimmons, S. M.; Hillebrand, A.; van Straaten, E. C.; Stam, C. J.; de Witt Hamer, P. C.; Baayen, J. C.; Klein, M.; Reijneveld, J. C.; Heyer, D. B.; Verhoog, M. B.; Wilbers, R.; Hunt, S.; Mansvelder, H. D.; Geurts, J. J.; de Kock, C. P.; Goriounova, N. A.

10.1101/2021.01.31.428369 — neuroscience — Posted on 2021-02-01

4246 A neuroendocrine pathway modulating osmotic stress in Drosophila

Zandawala, M.; Nguyen, T.; Segura, M. B.; Johard, H.; Amcoff, M.; Wegener, C.; Paluzzi, J.-P.; Nassel, D. R.

10.1101/522441 — neuroscience — Posted on 2021-02-01

4247 A preferential role for ventromedial prefrontal cortex in assessing the value of the whole in multi-attribute object evaluation

Pelletier, G.; Aridan, N.; Fellows, L. K.; Schonberg, T.

10.1101/2020.09.29.319293 — neuroscience — Posted on 2021-02-01

4248 Multidimensional brain-age prediction reveals altered brain developmental trajectory in psychiatric disorders

Niu, X.; Talyer, A.; Shinohara, R. T.; Kounios, J.; Zhang, F.

10.1101/2020.12.24.424350 — neuroscience — Posted on 2021-02-01

4249 Single cell analysis of population-wide nuclear and cytosolic drug responses using high-content FRET imaging: measuring protein kinase activation in rat primary striatal neurons

Jones-Tabah, J.; Martin, R. D.; Tanny, J.; Clarke, P. B. S.; Hebert, T.

10.1101/2021.01.31.429059 — neuroscience — Posted on 2021-02-01

4250 Chemogenetic activation of nigrostriatal dopamine neurons in freely moving common marmosets

Mimura, K.; Nagai, Y.; Inoue, K.-i.; Matsumoto, J.; Hori, Y.; Sato, C.; Takada, M.; Suhara, T.; Higuchi, M.; Minamimoto, T.

10.1101/2021.01.29.428749 — neuroscience — Posted on 2021-02-01

4251 Effects of arousal and movement on secondary somatosensory and visual thalamus

Petty, G. H.; Kinnischtzke, A.; Hong, Y. K.; Bruno, R. M.

10.1101/2020.03.04.977348 — neuroscience — Posted on 2021-02-01

4252 Visualization and Analysis of Whole Depot Adipose Tissue Neural Innervation

Willows, J. W.; Blaszkiewicz, M.; Lamore, A.; Borer, S.; Dubois, A. L.; Garner, E.; Breeding, W. P.; Tilbury, K. B.; Khalil, A.; Townsend, K. L.

10.1101/788885 — neuroscience — Posted on 2021-02-01

4253 Characterization of cognitive-motor function in women who have experienced intimate partner violence-related brain injury

Maldonado-Rodriguez, N.; Val Crocker, C.; Taylor, E.; Jones, K. E.; Rothlander, K.; Smirl, J.; Wallace, C.; van Donkelaar, P.

10.1101/2021.01.29.428699 — neuroscience — Posted on 2021-02-01

4254 The retrosplenial cortex combines internal and external cues to encode head velocity during navigation

Keshavarzi, S.; Bracey, E. F.; Faville, R. A.; Campagner, D.; Tyson, A. L.; Lenzi, S. C.; Branco, T.; Margrie, T. W.

10.1101/2021.01.22.427789 — neuroscience — Posted on 2021-02-01

4255 National Institutes of Health Institute and Center Award Rates and Funding Disparities

Lauer, M. S.; Doyle, J.; Wang, J.; Roychowdhury, D.

10.1101/2020.12.27.424490 — scientific communication and education — Posted on 2021-02-01

4256 FGF21 Normalizes Plasma Glucose in Mouse Models of Type 1 Diabetes and Insulin Receptor Dysfunction

Diener, J. L.; Mowbray, S.; Yowe, D.; Xu, J.; Caplan, S.; Misra, A.; Kapur, A.; Huang, W.-J.; Shapiro, J.; Ke, X.; Wu, X.; Bose, A.; Panza, D.; Chen, M.; Beaulieu, V.; Gao, J.

10.1101/2021.01.04.425295 — pharmacology and toxicology — Posted on 2021-02-01

4257 FGFR2 fusion proteins drive oncogenic transformation of mouse liver organoids towards cholangiocarcinoma

Cristinziano, G.; Porru, M.; Lamberti, D.; Buglioni, S.; Rollo, F.; Amoreo, C. A.; Manni, I.; Giannarelli, D.; Cristofoletti, C.; Russo, G.; Borad, M. J.; Grazi, G. L.; Diodoro, M. G.; Giordano, S.; Sacconi, A.; Forcato, M.; Anastasi, S.; Leonetti, C.; Segatto, O.

10.1101/2020.05.20.106104 — cancer biology — Posted on 2021-02-01

4258 Crystal structure determination of the armadillo repeat domain of Drosophila SARM1 using MIRAS phasing

Gu, W.; Luo, Z.; Vonrhein, C.; Jia, X.; Ve, T.; Nanson, J. D.; Kobe, B.

10.1101/2021.01.31.428505 — biophysics — Posted on 2021-02-01

4259 Clearing spheroids for 3D fluorescent microscopy:combining safe and soft chemicals with deep convolutional neural network

Ahmad, A.; Goodarzi, S.; Frindel, C.; Recher, G.; Riviere, C.; Rousseau, D.

10.1101/2021.01.31.428996 — bioinformatics — Posted on 2021-02-01

4260 Deep learning integration of molecular and interactome data for protein-compound interaction prediction

Watanabe, N.; Ohnuki, Y.; Sakakibara, Y.

10.1101/2021.01.31.429000 — bioinformatics — Posted on 2021-02-01

4261 Geographic heterogeneity impacts drug resistance predictions in Mycobacterium tuberculosis

Gan, G. L.; Nguyen, M.; Willie, E.; Rezaie, M.; Lee, B.; Chauve, C.; Libbrecht, M.; Chindelevitch, L.

10.1101/2020.09.17.301226 — bioinformatics — Posted on 2021-02-01

4262 Network science inspires novel tree shape statistics

Chindelevitch, L.; Hayati, M.; Poon, A.; Colijn, C.

10.1101/608646 — bioinformatics — Posted on 2021-02-01

4263 Evolving cryo-EM structural approaches for GPCR drug discovery

Zhang, X.; Johnson, R. M.; Drulyte, I.; Yu, L.; Kotecha, A.; Danev, R.; Wootten, D.; Sexton, P. M.; Belousoff, M. J.

10.1101/2021.01.11.426276 — biochemistry — Posted on 2021-02-01

4264 SCOPE: Flexible targeting and stringent CARF activation enables type III CRISPR-Cas diagnostics

Steens, J. A.; Zhu, Y.; Taylor, D. W.; Bravo, J. P. K.; Prinsen, S. H. P.; Schoen, C. D.; Keijser, B. J. F.; Ossendrijver, M.; Hofstra, L. M.; Brouns, S. J. J.; Shinkai, A.; van der Oost, J.; Staals, R. H. J.

10.1101/2021.02.01.429135 — biochemistry — Posted on 2021-02-01

4265 Effect of Silicon Application on Leaf mineral Composition of Eucalyptus

Kumar, R.; Reddy, D. K.; Kaushik, P.

10.1101/2021.01.31.429072 — biochemistry — Posted on 2021-02-01

4266 Metabolic differentiation of co-occurring Accumulibacter clades revealed through genome-resolved metatranscriptomics

McDaniel, E. A.; Moya-Flores, F.; Keene Beach, N.; Camejo, P. Y.; Oyserman, B. O.; Kizaric, M.; Khor, E. H.; Noguera, D. R.; McMahon, K. D.

10.1101/2020.11.23.394700 — genomics — Posted on 2021-02-01

4267 Non-essential ribosomal proteins in bacteria and archaea identified using COGs

Galperin, M. Y.; Wolf, Y. I.; Garushyants, S. K.; Vera Alvarez, R.; Koonin, E. V.

10.1101/2021.01.31.429008 — genomics — Posted on 2021-02-01

4268 Consistency of non-cognitive skills and their relation to educational outcomes in a UK cohort

Morris, T. T.; Davey Smith, G.; Van den Berg, G.; Davies, N. M.

10.1101/470682 — genetics — Posted on 2021-02-01

4269 Schizosaccharomyces pombe KAT5 contributes to resection and repair of a DNA double strand break

Li, T.; Petreaca, R. C.; Forsburg, S. L.

10.1101/2020.06.03.132316 — genetics — Posted on 2021-02-01

4270 Common breast cancer risk loci predispose to distinct tumor subtypes

Ahearn, T. U.; Zhang, H.; Michailidou, K.; Milne, R. L.; Bolla, M. K.; Dennis, J.; Dunning, A. M.; Lush, M.; Wang, Q.; Andrulis, I. L.; Anton-Culver, H.; Arndt, V.; Aronson, K. J.; Auer, P. L.; Augustinsson, A.; Baten, A.; Becher, H.; Behrens, S.; Benitez, J.; Bermisheva, M.; Blomqvist, C.; Bojesen, S. E.; Bonanni, B.; Borresen-Dale, A.-L.; Brauch, H.; Brenner, H.; Brooks-Wilson, A.; Bruning, T.; Burwinkel, B.; Canzian, F.; Castelao, J. E.; Chang-Claude, J.; Chanock, S.; Chenevix-Trench, G.; Clarke, C. L.; NBCS Collaborators, ; Collee, J. M.; Cox, A.; Cross, S. S.; Czene, K.; Daly, M. B.; Dev

10.1101/733402 — genetics — Posted on 2021-02-01

4271 Independent origins of the Golgi phosphoprotein 3 oncoprotein gene

Opazo, J. C.; Vandewege, M. W.; Gutierrez, J.; Zavala, K.; Vargas-Chacoff, L.; Morera, F. J.; Mardones, G. A.

10.1101/2021.01.31.429031 — evolutionary biology — Posted on 2021-02-01

4272 Viral evolutionary dynamics predict Influenza-Like-Illnesses in patients

Wallbank, C.; Aris-Brosou, S.

10.1101/2021.01.31.429026 — evolutionary biology — Posted on 2021-02-01

4273 Mitochondrial energy dysfunction induces remodeling of the cardiac mitochondrial protein acylome

Peoples, J. N.; Ghazal, N.; Duong, D. M.; Hardin, K. R.; Seyfried, N. T.; Faundez, V.; Kwong, J. Q.

10.1101/2021.01.31.429057 — cell biology — Posted on 2021-02-01

4274 Arylsulfonamide mediated RBM39 degradation causes aberrant splicing of mitotic kinesins

Coomar, S.; Penson, A.; Schwaller, J.; Abdel-Wahab, O.; Gillingham, D.

10.1101/2021.02.01.428819 — molecular biology — Posted on 2021-02-01

4275 CSF metabolites associate with CSF tau and improve prediction of Alzheimer's disease status

Dong, R.; Darst, B. F.; Deming, Y.; Ma, Y.; Lu, Q.; Zetterberg, H.; Blennow, K.; Carlsson, C. M.; Johnson, S. C.; Asthana, S.; Engelman, C. D.

10.1101/2021.01.31.429054 — molecular biology — Posted on 2021-02-01

4276 Genome-scale metabolic modelling of P. thermoglucosidasius NCIMB 11955 reveals metabolic bottlenecks in anaerobic metabolism.

Mol, V.; Bennett, M.; Sanchez, B. J.; Lisowska, B. K.; Herrgard, M. J.; Toftgaard Nielsen, A.; Leak, D. J.; Sonnenschein, N.

10.1101/2021.02.01.429138 — microbiology — Posted on 2021-02-01

4277 The conserved serine transporter SdaC moonlights to enable self recognition

Chittor, A.; Gibbs, K. A.

10.1101/2021.02.01.428846 — microbiology — Posted on 2021-02-01

4278 Metagenomic screening for lipolytic genes reveals an ecology-clustered distribution pattern

Lu, M.; Schneider, D.; Daniel, R.

10.1101/2021.02.01.429111 — microbiology — Posted on 2021-02-01

4279 Induction of selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir

Rao, S.; Lungu, C.; Crespo, R.; Steijaert, T. H.; Gorska, A.; Palstra, R.-J.; Prins, H. A. B.; van Ijcken, W.; Rokx, C.; Mueller, Y. M.; Van Kampen, J. J. A.; Verbon, A.; Katsikis, P. D.; Boucher, C. A. B.; Gruters, R. A.; Mahmoudi, T.

10.1101/2020.08.26.266726 — microbiology — Posted on 2021-02-01

4280 Enhanced immunogenicity of a synthetic DNA vaccine expressing consensus SARS-CoV-2 Spike protein using needle-free immunization

Alamri, S. S.; Alluhaybi, K. A.; Alhabbab, R. Y.; Algaissi, A.; Almahboub, S.; Alfaleh, M. A.; Abujamel, T. S.; Abdulaal, W.; ElAssouli, M.-Z.; Alharbi, R.; Hassanain, M.; Hashem, A. M.

10.1101/2021.02.01.429219 — immunology — Posted on 2021-02-01

4281 Novel EGFRvIII-CAR transgenic mice for rigorous preclinical studies in syngeneic mice

Chuntova, P.; Hou, Y.; Naka, R.; Goretsky, Y.; Nejo, T.; Kohanbash, G.; Chen, T.; Mende, A. L.; Montoya, M.; Yamamichi, A.; Downey, K. M.; Diebold, D.; Skinner, J.; Liang, H.-E.; Schwer, B.; Okada, H.

10.1101/2021.01.31.429020 — immunology — Posted on 2021-02-01

4282 ICOS signaling limits regulatory T cell accumulation and function in visceral adipose tissue

Mittelsteadt, K. L.; Hayes, E. T.; Campbell, D. J.

10.1101/2020.06.01.128504 — immunology — Posted on 2021-02-01

4283 In for a pound, in for a penny: How the opportunity to gain reward influences the competition for memory resources

Talmi, D.; Kavaliauskaite, D.; Daw, N. D.

10.1101/464388 — neuroscience — Posted on 2021-02-01

4284 Outer Hair Cell Function is Normal in βV Spectrin Knockout Mice

Stankewich, M. C.; Bai, J.-P.; Stabach, P. R.; Khan, S.; Song, L.; Morrow, J. S.; Santos-Sacchi, J.; Navaratnam, D. S.

10.1101/2021.02.01.427491 — neuroscience — Posted on 2021-02-01

4285 Nanotraps for the containment and clearance of SARS-CoV-2

Chen, M.; Rosenberg, J.; Cai, X.; Lee, A. C. H.; Shi, J.; Nguyen, M.; Wignakumar, T.; Mirle, V.; Edobor, A. J.; Fung, J.; Donington, J. S.; Shanmugarajah, K.; Chang, E. B.; Randall, G.; Penaloza-MacMaster, P.; Tian, B.; Madariaga, M. L.; Huang, J.

10.1101/2021.02.01.428871 — bioengineering — Posted on 2021-02-01

4286 Monitoring mitochondrial translation by pulse SILAC

Imami, K.; Selbach, M.; Ishihama, Y.

10.1101/2021.01.31.428997 — biochemistry — Posted on 2021-02-01

4287 Drosophila Evolution over Space and Time (DEST) - A New Population Genomics Resource

10.1101/2021.02.01.428994 — genomics — Posted on 2021-02-01

4288 Consequences of combining sex-specific life-history traits

Revathi Venkateswaran, V.; Roth, O.; Gokhale, C. S.

10.1101/2020.01.03.892810 — evolutionary biology — Posted on 2021-02-01

4289 REFINING THE IDENTITY AND ROLE OF KV4 CHANNELS IN MOUSE SUBSTANTIA NIGRA DOPAMINERGIC NEURONS

Haddjeri-Hopkins, A.; Tapia, M.; Ramirez-Franco, J.; Tell, F.; Marqueze-Pouey, B.; Amalric, M.; Goaillard, J.-M.

10.1101/2021.02.01.429100 — neuroscience — Posted on 2021-02-01

4290 Cell-type specific expression and behavioral impact of galanin and GalR1 in the locus coeruleus during opioid withdrawal

Foster, S. L.; Galaj, E.; Karne, S. L.; Ferre, S.; Weinshenker, D.

10.1101/2021.01.31.428998 — neuroscience — Posted on 2021-02-01

4291 Identification of a conserved neutralizing epitope present on spike proteins from highly pathogenic coronaviruses

Huang, Y.; Nguyen, A. W.; Hsieh, C.-L.; Silva, R.; Olaluwoye, O. S.; Wilen, R.; Kaoud, T. S.; Azouz, L. R.; Qerqez, A. N.; Le, K. C.; Bohanon, a. L.; DiVenere, A. M.; Liu, Y.; Amengor, D.; Dalby, K.; D'Arcy, S.; McLellan, J. S.; Maynard, J. A.

10.1101/2021.01.31.428824 — biochemistry — Posted on 2021-02-01

4292 Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release

Ijäs, H.; Shen, B.; Heuer-Jungemann, A.; Keller, A.; Kostiainen, M. A.; Liedl, T.; Ihalainen, J. A.; Linko, V.

10.1101/2020.05.13.088054 — biochemistry — Posted on 2021-02-01

4293 Environmentally-induced mdig is a major contributor to the severity of COVID-19 through fostering expression of SARS-CoV-2 receptor NRPs and glycan metabolism

Chen, F.

10.1101/2021.01.31.429010 — cell biology — Posted on 2021-02-01

4294 Kinesin-3 and kinesin-1 motors direct basement membrane protein secretion to a basal sub-region of the basolateral plasma membrane in epithelial cells

Zajac, A. L.; Horne-Badovinac, S.

10.1101/2021.01.31.429062 — cell biology — Posted on 2021-02-01

4295 Nelfinavir markedly improves lung pathology in SARS-CoV-2-infected Syrian hamsters despite a lack of an antiviral effect

Foo, C. S.; Abdelnabi, R.; Kaptein, S. J. F.; Zhang, X.; ter Horst, S.; Mols, R.; Delang, L.; Rocha-Pereira, J.; Coelmont, L.; Leyssen, P.; Dallmeier, K.; Vergote, V.; Heylen, E.; Vangeel, L.; Chatterjee, A. K.; Annaert, P.; Augustijns, P.; De Jonghe, S.; Jochmans, D.; Weynand, B.; Neyts, J.

10.1101/2021.02.01.429108 — microbiology — Posted on 2021-02-01

4296 Sequential delivery of LAIV and SARS-CoV-2 in the ferret model can reduce SARS-CoV-2 shedding and does not result in enhanced lung pathology.

Ryan, K. A.; Schewe, K. E.; Crowe, J.; Fotheringham, S. A.; Hall, Y.; Humphreys, R.; Marriott, A. C.; Paterson, J.; Rayner, E.; Salguero, F. J.; Watson, R. J.; Whittaker, C. J.; Carroll, M. W.; Dibben, O.

10.1101/2021.02.01.429110 — microbiology — Posted on 2021-02-01

4297 Identification of anti-severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) oxysterol derivatives in vitro

Ohashi, H.; Wang, F.; Stappenbeck, F.; Tsuchimoto, K.; Kobayashi, C.; Saso, W.; Kataoka, M.; Kuramochi, K.; Muramatsu, M.; Suzuki, T.; Sureau, C.; Takeda, M.; Wakita, T.; Parhami, F.; Watashi, K.

10.1101/2021.01.31.429001 — microbiology — Posted on 2021-02-01

4298 Mn2+ coordinates Cap-0-RNA to align substrates for efficient 2'-O-methyl transfer by SARS-CoV-2 nsp16

Minasov, G.; Rosas-Lemus, M.; Shuvalova, L.; Inniss, N. L.; Brunzelle, J. S.; Daczkowski, C. M.; Hoover, P.; Mesecar, A. D.; Satchell, K. J.

10.1101/2021.01.31.429023 — microbiology — Posted on 2021-02-01

4299 Expression of human ACE2 N-terminal domain, part of the receptor for SARS-CoV-2, in fusion with maltose binding protein, E. coli ribonuclease I and human RNase A

Xu, S.-y.; Fomenkov, A.; Chen, T.-H.; Yigit, E.

10.1101/2021.01.31.429007 — microbiology — Posted on 2021-02-01

4300 Discovery of re-purposed drugs that slow SARS-CoV-2 replication in human cells

Pickard, A.; Calverley, B. C.; Chang, J.; Garva, R.; Lu, Y.; Kadler, K. E.

10.1101/2021.01.31.428851 — immunology — Posted on 2021-02-01

4301 TMEM97 increases in synapses and is a potential synaptic Aβ binding partner in human Alzheimer's disease

Colom-Cadena, M.; Tulloch, J.; Jackson, R. J.; Catterson, J. H.; Rose, J.; Davies, C.; Hooley, M.; Anton-Fernandez, A.; Dunnett, S.; Tempelaar, R.; Tzioras, M.; Izzo, N. J.; Catalano, S. M.; Smith, C.; Spires-Jones, T. L.

10.1101/2021.02.01.428238 — neuroscience — Posted on 2021-02-01

4302 coronaSPAdes: from biosynthetic gene clusters to RNA viral assemblies

Meleshko, D.; Hajirasouliha, I.; Korobeynikov, A.

10.1101/2020.07.28.224584 — bioinformatics — Posted on 2021-02-01

4303 Trial-to-trial variability of spiking delay activity in prefrontal cortex constrains burst-coding models of working memory

Li, D.; Constantinidis, C.; Murray, J. D.

10.1101/2021.01.30.428962 — neuroscience — Posted on 2021-02-01

4304 CDSeqR: fast complete deconvolution for gene expression data from bulk tissues

Kang, K.; Huang, C.; Li, Y.; Umbach, D. M.; Li, L.

10.1101/2021.01.30.428954 — bioinformatics — Posted on 2021-02-01

4305 Cortical Microcircuitry of Executive Control and Source of Associated Event-Related Potentials

Sajad, A.; Errington, S. P.; Schall, J. D.

10.1101/2021.01.30.428901 — neuroscience — Posted on 2021-02-01

4306 Moving outside the lab: The viability of conducting sensorimotor learning studies online

Tsay, J. S.; Lee, A. S.; Ivry, R. B.; Avraham, G.

10.1101/2021.01.30.181370 — neuroscience — Posted on 2021-02-01

4307 7-Dehydrocholesterol-derived oxysterols cause neurogenic defects in Smith-Lemli-Opitz syndrome

Tomita, H.; Hines, K. M.; Herron, J. M.; Li, A.; Baggett, D. W.; Xu, L.

10.1101/2021.01.30.428955 — neuroscience — Posted on 2021-02-01

4308 Prefrontal-motor and somatosensory-motor cortical network interactions during reactive balance are associated with distinct aspects of balance behavior in older adults

Palmer, J.; Payne, A. M.; Ting, L. H.; Borich, M. R.

10.1101/2021.01.30.428951 — neuroscience — Posted on 2021-02-01

4309 Ribosome Profiling Reveals a Dichotomy Between Ribosome Occupancy of Nuclear-Encoded and Mitochondrial-Encoded OXPHOS mRNA Transcripts in a Striatal Cell Model of Huntington Disease

Subramaniam, S.; Shahani, N.

10.1101/2021.01.30.428960 — neuroscience — Posted on 2021-02-01

4310 Pupillary aperture is a potential biomarker ofmovement preparation

Pandey, P.; Ray, S.

10.1101/2021.01.30.428981 — neuroscience — Posted on 2021-02-01

4311 Robust, sensitive, and quantitative single-cell proteomics based on ion mobility filtering

Woo, J.; Clair, G. C.; Williams, S. M.; Feng, S.; Moore, R. J.; Chrisler, W. B.; Smith, R. D.; Kelly, R. T.; Pasa-Tolic, L.; Ansong, C.; Zhu, Y.

10.1101/2021.01.30.428333 — systems biology — Posted on 2021-02-01

4312 Regulation of lateral root development by shoot-sensed far-red light via HY5 is nitrate-dependent and involves the NRT2.1 nitrate transporter.

van Gelderen, K.; Kang, C.-K.; Li, P.; Pierik, R.

10.1101/2021.01.31.428985 — plant biology — Posted on 2021-02-01

4313 Evolution of the bread wheat D-subgenome and enriching it with diversity from Aegilops tauschii

Gaurav, K.; Arora, S.; Silva, P.; Sanchez-Martin, J.; Horsnell, R.; Gao, L.; Brar, G. S.; Widrig, V.; Raupp, J.; Singh, N.; Wu, S.; Kale, S. M.; Chinoy, C.; Nicholson, P.; Quiroz-Chavez, J.; Simmonds, J.; Hayta, S.; Smedley, M. A.; Harwood, W.; Pearce, S.; Gilbert, D.; Kangara, N.; Gardener, C.; Forner-Martinez, M.; Liu, J.; Yu, G.; Boden, S.; Pascuccci, A.; Ghosh, S.; Hafeez, A. N.; O'Hara, T.; Waites, J.; Cheema, J.; Steuernagel, B.; Patpour, M.; Justesen, A. F.; Liu, S.; Rudd, J.; Avni, R.; Sharon, A.; Steiner, B.; Kirana, R. P.; Buerstmayr, H.; Mehrabi, A. A.; Nasyrova, F. Y.; Chayut, N.;

10.1101/2021.01.31.428788 — plant biology — Posted on 2021-02-01

4314 Surviving hypothermia by ferritin-mediated iron detoxification

Pekec, T.; Lewandowski, J.; Komur, A. A.; Sobanska, D.; Guo, Y.; Switonska-Kurkowska, K.; Frankowski, M.; Figiel, M.; Ciosk, R.

10.1101/2021.01.30.428937 — physiology — Posted on 2021-02-01

4315 Vasoconstriction in isolated goat aorta does not increase mean aortic pressure

Gangadharan, N.; V, A.; Jebaraj, B.; Zachariah, S. M.; Devasahayam, S.; Saravana Kumar, G.; Subramani, S.

10.1101/2021.01.30.428980 — physiology — Posted on 2021-02-01

4316 MYC controls metastatic heterogeneity in pancreatic cancer

Maddipati, R.; Norgard, R.; Baslan, T.; Rathi, K.; Zhang, A.; Raman, P.; Pitarresi, J.; Wengyn, M.; Yamazoe, T.; Li, J.; Balli, D.; LaRiviere, M.; Folkert, I.; Millstein, I.; Bermeo, J.; Carpenter, E.; Lowe, S.; Iacobuzio-Donahue, C. A.; Notta, F.; Stanger, B.

10.1101/2021.01.30.428641 — cancer biology — Posted on 2021-02-01

4317 Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer

Pelka, K.; Hofree, M.; Chen, J.; Sarkizova, S.; Pirl, J. D.; Jorgji, V.; Bejnood, A.; Dionne, D.; Ge, W. H.; Xu, K. H.; Chao, S. X.; Zollinger, D. R.; Lieb, D. J.; Reeves, J. W.; Fuhrman, C. A.; Hoang, M. L.; Delorey, T.; Nguyen, L. T.; Waldmann, J. A.; Klapholz, M.; Wakiro, I.; Cohen, O.; Smillie, C. S.; Cuoco, M. S.; Wu, J.; Su, M.-j.; Yeung, J.; Vijaykumar, B.; Magnuson, A. M.; Asinovski, N.; Moll, T.; Goder-Reiser, M. N.; Applebaum, A. S.; Brais, L. K.; DelloStritto, L. K.; Denning, S. L.; Phillips, S. T.; Hill, E. K.; Meehan, J. K.; Frederick, D. T.; Sharova, T.; Kanodia, A.; Todres, E. Z

10.1101/2021.01.30.426796 — cancer biology — Posted on 2021-02-01

4318 Water as a reactant in the first step of triosephosphate isomerase catalysis

Callis, P. R.; Yates, M.

10.1101/2021.01.30.427993 — biophysics — Posted on 2021-02-01

4319 Membrane barrels are taller, fatter, inside-out soluble barrels

Dhar, R.; Feehan, R.; Slusky, J. S. G.

10.1101/2021.01.30.428970 — biophysics — Posted on 2021-02-01

4320 Tools enabling flexible approaches to high-resolution subtomogram averaging

Burt, A.; Gaifas, L.; Dendooven, T.; Gutsche, I.

10.1101/2021.01.31.428990 — biophysics — Posted on 2021-02-01

4321 Thermodynamic modeling reveals widespread multivalent binding by RNA-binding proteins

Sohrabi-Jahromi, S.; Soeding, J.

10.1101/2021.01.30.428941 — bioinformatics — Posted on 2021-02-01

4322 AhNGE : A Database for Arachis hypogaea Nodule Developmental Gene Expression

Shaheen, T.; Tembhare, K.; Singh, A.; Raul, B.; Ghosh, A. K.; Torres-Jerez, I.; Clevenger, J.; Udvardi, M.; Scheffler, B.; Ozias-Akins, P.; Bandyopadhyay, K.; Kumar, S.; Sinharoy, S.

10.1101/2021.01.30.428929 — bioinformatics — Posted on 2021-02-01

4323 PalaCell2D: A framework for detailed tissue morphogenesis

Conradin, R.; Coreixas, C.; Latt, J.; Chopard, B.

10.1101/2021.01.30.428940 — bioinformatics — Posted on 2021-02-01

4324 In silico assessment of missense point mutations on human cathelicidin LL-37

Porto, W. F.; Alencar, S. A.

10.1101/2021.01.30.428671 — bioinformatics — Posted on 2021-02-01

4325 Super-delta2: An Enhanced Differential Expression Analysis Procedure for Multi-Group Comparisons of RNA-seq Data

Cui, Z.; Liu, Y.; Zhang, J.; Qiu, X.

10.1101/2021.01.30.428977 — bioinformatics — Posted on 2021-02-01

4326 Attention is all you need for general-purpose protein structure embedding

Cui, X.

10.1101/2021.01.31.428935 — bioinformatics — Posted on 2021-02-01

4327 dSCOPE: a software to detect sequences critical for liquid-liquid phase separation

Li, S.; Yu, K.; Zhang, Q.; Liu, Z.; Liu, J.; Ju, H.-Q.; Zuo, Z.; Li, X.; Wang, Z.; Cheng, H.; Liu, Z.-X.

10.1101/2021.01.30.428971 — bioinformatics — Posted on 2021-02-01

4328 Improving sequence-based modeling of protein families using secondary structure quality assessment

Malbranke, C.; Bikard, D.; Cocco, S.; Monasson, R.

10.1101/2021.01.31.428964 — bioinformatics — Posted on 2021-02-01

4329 Manipulation of stimulus waveform and frequency permits targeted fiber activation during vagus nerve stimulation in 2 rodent species

Chang, Y.-C.; Ahmed, U.; Jayaprakash, N.; Abbas, A.; Lin, Q.; Mughrabi, I.; Guo, T.; Wu, Y.-C.; Gabalski, A. H.; Daytz, A.; Ashville, J.; Dokos, S.; Al-Abed, Y.; Zanos, S.

10.1101/2021.01.30.428827 — bioengineering — Posted on 2021-02-01

4330 Production of SARS-CoV-2 virus-like particles in insect cells

mi, Y.; Xie, T.; Zhu, B.; tan, J.; Li, X.; Luo, Y.; Li, F.; Niu, H.; Han, J.; Lv, W.; Wang, J.

10.1101/2021.01.30.428979 — bioengineering — Posted on 2021-02-01

4331 A Facile and Rapid Route to Self-Digitization of Samples into a High Density Microwell Array for Digital Bioassays

Cui, X.; Hu, T.; Chen, Q.; Zhao, Q.; Wu, Y.; Xie, T.; Liu, P.; Su, X.; Li, G.

10.1101/2021.01.31.428989 — bioengineering — Posted on 2021-02-01

4332 Larval zebrafish display dynamic learning of aversive stimuli in a constant visual surrounding

Xu, J.; Casanave, R.; Guo, S.

10.1101/2021.01.30.428906 — animal behavior and cognition — Posted on 2021-02-01

4333 Is energetics or competition a stronger driver of male smallmouth bass seasonal reproductive timing?

Laroche, R. A. S.; Weinersmith, K. L.; Angeloni, L.; Baylis, J. R.; Newman, S. P.; Egan, S. P.; Wiegmann, D. D.

10.1101/2021.01.30.428956 — animal behavior and cognition — Posted on 2021-02-01

4334 A genome-wide screen in the mouse liver reveals sex-specific and cell non-autonomous regulation of cell fitness

Keys, H. R.; Knouse, K. A.

10.1101/2021.01.30.428976 — genomics — Posted on 2021-02-01

4335 piRNAs Coordinate poly(UG) Tailing to Prevent Aberrant and Permanent Gene Silencing

Shukla, A.; Perales, R.; Kennedy, S.

10.1101/2021.01.30.428010 — genetics — Posted on 2021-02-01

4336 Small Intestinal Resident Eosinophils Maintain Gut Homeostasis Following Microbial Colonisation

Shah, K.; Ignacio, A.; Bernier-Latmani, J.; Koeller, Y.; Coakley, G.; Moyat, M.; Hamelin, R.; Armand, F.; Wong, N. C.; Remay, H.; Thomson, C. A.; Bukhard, R.; Dufour, A.; Petrova, T. V.; Harris, N. L.; McCoy, K. D.

10.1101/2021.01.30.428930 — immunology — Posted on 2021-02-01

4337 Individual structural MRI abnormality indexes are associated with molecular,histological and cognitive indicators for frontal glioma patients

Zhang, G.; Huang, H.; Wang, Y.; Zhang, X.; Li, H.; Duan, Y.; Chen, H.; Liu, Y.; Jing, B.; Lin, S.

10.1101/2021.01.30.428923 — neuroscience — Posted on 2021-02-01

4338 Non cell-autonomous effect of astrocytes on cerebral cavernous malformations

Lopez-Ramirez, M. A. A.; Soliman, S. I.; Hale, P.; Lai, C. C.; Pham, A.; Estrada, E. J.; McCurdy, S.; Girard, R.; Verma, R.; Moore, T.; Lightle, R.; Hobson, N.; Shenkar, R.; Poulsen, O.; Haddad, G. G.; Daneman, R.; Gongol, B.; Sun, H.; Lagarrigue, F.; Awad, I. A.; Ginsberg, M.

10.1101/2021.01.29.428891 — neuroscience — Posted on 2021-02-01

4339 Sense of Agency for Mental Actions: Insights from a Belief-Based Action-Effect Paradigm

Lopez-Sola, E.; Arsiwalla, X. D.; Moreno-Bote, R.

10.1101/2021.01.30.428924 — neuroscience — Posted on 2021-02-01

4340 Aperiodic measures of neural excitability are associated with anticorrelated hemodynamic networks at rest: a combined EEG-fMRI study

Jacob, M.; Roach, B.; Sargent, K.; Mathalon, D.; Ford, J.

10.1101/2021.01.30.427861 — neuroscience — Posted on 2021-02-01

4341 Separated and overlapping neural coding of face and body identity

Foster, C.; Zhao, M.; Bolkart, T.; Black, M. J.; Bartels, A.; Buelthoff, I.

10.1101/2021.01.30.428936 — neuroscience — Posted on 2021-02-01

4342 A Mixture Model Incorporating Individual Heterogeneity in Human Lifetimes

Huang, F.; Maller, R.; Milholland, B.; Ning, X.

10.1101/2021.01.29.428902 — systems biology — Posted on 2021-02-01

4343 How certain are we? Development of an ensemble based framework for assessing astronaut cancer risks from space radiation

Simonsen, L. C.; Slaba, T. C.

10.1101/2021.01.29.428854 — biophysics — Posted on 2021-02-01

4344 GraphUnzip: unzipping assembly graphs with long reads and Hi-C

Faure, R.; Guiglielmoni, N.; Flot, J.-F.

10.1101/2021.01.29.428779 — bioinformatics — Posted on 2021-02-01

4345 HashSeq: A Simple, Scalable, and Conservative De Novo Variant Caller for 16S rRNA Gene Datasets

Fouladi, F.; Young, J. B.; Fodor, A. A.

10.1101/2021.01.29.428714 — bioinformatics — Posted on 2021-02-01

4346 Morphological Metrics of Magnetic Resonance Imaging of Glioblastoma as Biomarkers of Prognosis

Curtin, L.; Whitmire, P.; White, H.; Mrugala, M. M.; Hu, L. S.; Swanson, K. R.

10.1101/2021.01.29.428875 — bioinformatics — Posted on 2021-02-01

4347 PATO: Pangenome Analysis Toolkit

Fernandez-de-Bobadilla, M. D.; Talavera-Rodriguez, A.; Chacon, L.; Baquero, F.; Coque, T. M.; Lanza, V. F.

10.1101/2021.01.30.428878 — bioinformatics — Posted on 2021-02-01

4348 Expected 10-anonymity of HyperLogLog sketches for federated queries of clinical data repositories

Tao, Z.; Weber, G. M.; Yu, Y. W.

10.1101/2021.01.30.428918 — bioinformatics — Posted on 2021-02-01

4349 Rest-fMRI Based Comparison Study between Autism Spectrum Disorder and Typically Control Using Graph Frequency Bands

Jafadideh, A. T.; Mohammadzadeh Asl, B.

10.1101/2021.01.29.428745 — bioengineering — Posted on 2021-02-01

4350 SFARI Genes and where to find them; classification modelling to identify genes associated with Autism Spectrum Disorder from RNA-seq data

Navarro, M.; Simpson, I.

10.1101/2021.01.29.428754 — genomics — Posted on 2021-02-01

4351 Functional and comparative genome analysis reveals clade-specific genome innovations in the killer fungus Candida auris

Narayanan, A.; Vadnala, R. N.; Ganguly, P.; Selvakumar, P.; Rudramurthy, S.; Prasad, R.; Chakrabarti, A.; Siddharthan, R.; Sanyal, K.

10.1101/2021.01.29.428909 — genomics — Posted on 2021-02-01

4352 Modeling Vertical Migrations of Zooplankton Based on Maximizing Fitness

Kuzenkov, O.; Ryabova, E.; Garcia Garcia, A.; Degtyarev, A.

10.1101/2021.01.29.428857 — evolutionary biology — Posted on 2021-02-01

4353 Agri-environment nectar chemistry suppresses parasite social epidemiology in an important pollinator

Folly, A. J.; Koch, H.; Farrell, I. W.; Stevenson, P. C.; Brown, M. J. F.

10.1101/2021.01.30.428928 — ecology — Posted on 2021-02-01

4354 Reparative macrophages regulate fibrosis in the infarcted myocardium by attenuating apoptosis and senescence of fibroblasts

Shiraishi, M.

10.1101/2021.01.29.428912 — molecular biology — Posted on 2021-02-01

4355 Cluster-specific gene markers enhance Shigella and Enteroinvasive Escherichia coli in silico serotyping

Zhang, X.; Payne, M.; Nguyen, T.; Kaur, S.; Lan, R.

10.1101/2021.01.30.428723 — microbiology — Posted on 2021-02-01

4356 Defensive freezing and its relation to approach-avoidance decision-making under threat

Klaassen, F. H.; Held, L.; Figner, B.; O'Reilly, J. X.; Klumpers, F.; de Voogd, L. D.; Roelofs, K.

10.1101/2021.01.29.428809 — neuroscience — Posted on 2021-02-01

4357 Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in a foraging task.

Dongelmans, M.; Durand-de Cuttoli, R.; Nguyen, C.; Come, M.; Durante, E. K.; Lemoine, D.; Britto, R.; Yahia, T. A.; Mondoloni, S.; Didienne, S.; Bousseyrol, E.; Hannesse, B.; Reynolds, L. M.; Torquet, N.; Dalkara, D.; Marti, F.; Mourot, A.; Naude, J.; Faure, P.

10.1101/2021.01.29.428835 — neuroscience — Posted on 2021-02-01

4358 Just-in-time: gaze guidance behavior while action planning and execution in VR

Keshava, A.; Nezami, F. N.; Neumann, H.; Izdebski, K.; Schueler, T.; Koenig, P.

10.1101/2021.01.29.428782 — neuroscience — Posted on 2021-02-01

4359 Multi-Tissue Multi-Compartment models of diffusion MRI

Frigo, M.; Fick, R. H. J.; Zucchelli, M.; Deslauriers-Gauthier, S.; Deriche, R.

10.1101/2021.01.29.428843 — neuroscience — Posted on 2021-02-01

4360 Characterization of cognitive-motor function in women who have experienced intimate partner violence-related brain injury

Maldonado-Rodriguez, N.; Val Crocker, C.; Taylor, E.; Jones, K. E.; Rothlander, K.; Smirl, J.; Wallace, C.; van Donkelaar, P.

10.1101/2021.01.29.428699 — neuroscience — Posted on 2021-02-01

4361 Fat and carbohydrate interact to potentiate food reward in healthy weight but not in overweight or obesity

Perszyk, E. E.; Hutelin, Z.; Trinh, J.; Kanyamibwa, A.; Fromm, S.; Davis, X. S.; Wall, K. M.; Flack, K. D.; DiFeliceantonio, A.; Small, D. M.

10.1101/2021.01.29.428845 — neuroscience — Posted on 2021-02-01

4362 Small size of recorded neuronal structures confines the accuracy in direct axonal voltage measurements

Oláh, V. J.; Tarcsay, G.; Brunner, J.

10.1101/2021.01.29.428709 — neuroscience — Posted on 2021-02-01

4363 Trial-by-trial modulation of express visuomotor responses induced by symbolic or barely detectable cues

Contemori, S.; Loeb, G. E.; Corneil, B. D.; Wallis, G.; Carroll, T. J.

10.1101/2021.01.29.428908 — neuroscience — Posted on 2021-02-01

4364 DeepFrag: An Open-Source Browser App for Deep-Learning Lead Optimization

Green, H.; Durrant, J.

10.1101/2021.01.29.428897 — pharmacology and toxicology — Posted on 2021-02-01

4365 Improving protein tertiary structure prediction by deep learning and distance prediction in CASP14

Liu, J.; Wu, T.; Guo, Z.; Hou, J.; Cheng, J.

10.1101/2021.01.28.428706 — bioinformatics — Posted on 2021-02-01

4366 The Functional Order (FunOrder) tool - Identification of essential biosynthetic genes through computational molecular co-evolution

Vignolle, G. A.; Schaffer, D.; Mach, R. L.; Mach-Aigner, A. R.; Derntl, C.

10.1101/2021.01.29.428829 — bioinformatics — Posted on 2021-02-01

4367 MDM-TASK-web: A web platform for protein dynamic residue networks and modal analysis

Sheik Amamuddy, O.; Glenister, M.; Tastan Bishop, O.

10.1101/2021.01.29.428734 — bioinformatics — Posted on 2021-02-01

4368 Neptune: An environment for the delivery of genomic medicine

Venner, E.; Yi, V.; Murdock, D. R.; Kalla, S. E.; Wu, T.-J.; Sabo, A.; Li, S.; Meng, Q.; Tian, X.; Murugan, M.; Cohen, M.; Kovar, C.; Wei, W.-Q.; Chung, W.; Weng, C.; Weisner, G.; Jarvik, G.; Muzny, D. M.; Gibbs, R.

10.1101/2021.01.29.428608 — bioinformatics — Posted on 2021-02-01

4369 DeepRank: A deep learning framework for data mining 3D protein-protein interfaces

Renaud, N.; Geng, C.; Georgievska, S.; Ambrosetti, F.; Ridder, L.; Marzella, D. F.; Bonvin, A. M. J. J.; Xue, L. C.

10.1101/2021.01.29.425727 — bioinformatics — Posted on 2021-02-01

4370 Innate visual attraction in wood ants is a hardwired behaviour seen across different motivational and ecological contexts

Buehlmann, C.; Graham, P.

10.1101/2021.01.29.428794 — animal behavior and cognition — Posted on 2021-02-01

4371 Evolutionary genetic integration of behavioural and endocrine components of the stress response

Houslay, T. M.; Earley, R. L.; White, S. J.; Lammers, W.; Grimmer, A. J.; Travers, L.; Johnson, E.; Young, A. J.; Wilson, A. J.

10.1101/770586 — evolutionary biology — Posted on 2021-02-01

4372 Identifying loci under selection via explicit demographic models

Luqman, H.; Widmer, A.; Fior, S.; Wegmann, D.

10.1101/2020.07.20.211581 — evolutionary biology — Posted on 2021-02-01

4373 The imprinted Zdbf2 gene finely tunes control of feeding and growth in neonates

Glaser, J.; Iranzo, J.; Borensztein, M.; Marinucci, M.; Gualtieri, A.; Jouhanneau, C.; Teissandier, A.; Gaston-Massuet, C.; Bourc'his, D.

10.1101/2021.01.27.428419 — molecular biology — Posted on 2021-02-01

4374 A Mycobacterium tuberculosis effector targets mitochondrion, controls energy metabolism and limits cytochrome c exit.

Martin, M.; deVisch, A.; Barthe, P.; Turapov, O.; Aydogan, T.; Heriaud, L.; Gracy, J.; Mukamolova, G.; Letourneur, F.; Cohen-Gonsaud, M.

10.1101/2021.01.31.428746 — microbiology — Posted on 2021-02-01

4375 Macrophage Scavenger Receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease

Govaere, O.; Petersen, S. K.; Martinez-Lopez, N.; Wouters, J.; Van Haele, M.; Mancina, R. M.; Jamialahmadi, O.; Bilkei-Gorzo, O.; Lassen, P. B.; Darlay, R.; Peltier, J.; M. Palmer, J.; Younes, R.; Tiniakos, D.; Aithal, G. P.; Allison, M.; Vacca, M.; Goransson, M.; J. Drinnan, M.; Yki-Jarvinen, H.; Dufour, J.-F.; Ekstedt, M.; Francque, S.; Petta, S.; Bugianesi, E.; Schattenberg, J. M.; Day, C. P.; Cordell, H. J.; Topal, B.; Clement, K.; Romeo, S.; Ratziu, V.; Roskams, T.; Daly, A. K.; Anstee, Q. M.; Trost, M.; Hartlova, A.

10.1101/2020.02.01.930115 — immunology — Posted on 2021-02-01

4376 Non-parametric modelling of temporal and spatial counts data from RNA-seq experiments

BinTayyash, N.; Georgaka, S.; John, S.; Ahmed, S.; Boukouvalas, A.; Hensman, J.; Rattray, M.

10.1101/2020.07.29.227207 — bioinformatics — Posted on 2021-02-01

4377 HTSlib - C library for reading/writing high-throughput sequencing data

Bonfield, J. K.; Marshall, J.; Danecek, P.; Li, H.; Ohan, V.; Whitwham, A.; Keane, T.; Davies, R. M.

10.1101/2020.12.16.423064 — bioinformatics — Posted on 2021-02-01

4378 Structural and functional sex differences in the ventral pallidal vasopressin system are associated with the sex-specific regulation of juvenile social play behavior in rats

Lee, J. D. A.; Reppucci, C. J.; Bowden, S. M.; Huez, E. D. M.; Bredewold, R.; Veenema, A. H.

10.1101/2021.01.31.429043 — neuroscience — Posted on 2021-02-01

4379 Cortical Processing of Arithmetic and Simple Sentences in an Auditory Attention Task

Kulasingham, J. P.; Joshi, N. H.; Rezaeizadeh, M.; Simon, J. Z.

10.1101/2021.01.31.429030 — neuroscience — Posted on 2021-02-01

4380 Multimodal sensorimotor integration of visual and kinaesthetic afferents modulates motor circuits in humans

Zschorlich, V.; Behrendt, F.; de Lussanet, M. H. E.

10.1101/2021.01.31.429002 — neuroscience — Posted on 2021-02-01

4381 NAP-CNB: Bioinformatic pipeline to predict MHC-I-restricted T cell epitopes in mice

Wert-Carvajal, C.; Sanchez-Garcia, R.; Macias, J. R.; Sanz-Pamplona, R.; Mendez Perez, A.; Alemany, R.; Veiga, E.; Sorzano, C. O. S.; Munoz-Barrutia, A.

10.1101/2020.10.05.327015 — bioinformatics — Posted on 2021-02-01

4382 Long-read-sequenced reference genomes of the seven major lineages of enterotoxigenic Escherichia coli (ETEC) circulating in modern time

von Mentzer, A.; Blackwell, G.; Pickard, D.; Boinett, C. J.; Joffre, E.; Page, A. J.; Svennerholm, A.-M.; Dougan, G.; Sjöling, A.

10.1101/2020.07.16.203430 — genomics — Posted on 2021-02-01

4383 Genomic and demographic processes differentially influence genetic variation across the X chromosome

Cotter, D. J.; Webster, T. H.; Wilson, M. A.

10.1101/2021.01.31.429027 — genetics — Posted on 2021-02-01

4384 The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota

Bermudez-Martin, P.; Becker, J. J.; Caramello, N.; Fernandez, S. P.; Costa-Campos, R.; Canaguier, J.; Barbosa, S.; Martinez Gili, L.; Myridakis, A.; Dumas, M. E.; Bruneau, A.; Cherbuy, C.; Langella, P.; Callebert, J.; Launay, J.-M.; Chabry, J.; Barik, J.; Le Merrer, J.; Glaichenhaus, N.; Davidovic, L.

10.1101/2020.05.18.101147 — neuroscience — Posted on 2021-02-01

4385 Dendritic domain-specific sampling of long-range axons shapes feedforward and feedback connectivity of L5 neurons

Galloni, A. R.; Ye, Z.; Rancz, E.

10.1101/2021.01.31.429033 — neuroscience — Posted on 2021-02-01

4386 Fast gene set enrichment analysis

Korotkevich, G.; Sukhov, V.; Budin, N.; Shpak, B.; Artyomov, M. N.; Sergushichev, A.

10.1101/060012 — bioinformatics — Posted on 2021-02-01

Archive, 2021-02