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Archive, 2025-06

2 Depth-Resolved Macroscopic Fluorescence Lifetime Imaging via High-Spatial-Frequency Structured Illumination
Yuan, N.; Ragab, S.; Nizam, N. I.; Pandey, V.; Verma, A.; Young, T.; Williams, J. C.; Barroso, M.; Intes, X.
10.1101/2025.06.10.658928 — bioengineering — Posted on 2025-06-15
10 Innervation of Retrodiscal Tissues in Patients with Temporomandibular Joint Disorder
Alfaro, J. J.; Hovhannisyan, A. H.; Locke, E. E.; Amarista, F. J.; Perez, D. E.; Akopian, A. N.
10.1101/2025.06.11.659119 — neuroscience — Posted on 2025-06-15
11 Preventing Microglial Reactivity Protects from Acute and Progressive Neuronal Dysfunction, Motor Impairments and Sedation following Alcohol Abuse
Paouri, E.; Stanko, S.; Gasmi, N.; Glusauskas, G.; Mao, V.; Kwak, A.; Sarmadi, S.; Huang, E.; Hershberger, C.; Watercutter, Q.; Burton, H.; Crockett, A.; Gjojdeshi, A.; McMullen, M. R.; Hanamsagar, R. M.; Rotroff, D. M.; Prayson, R. A.; Bilbo, S. D.; Valadkhan, S.; Dana, H.; Nagy, L. E.; Davalos, D.
10.1101/2025.06.12.658437 — neuroscience — Posted on 2025-06-15
13 Proximity labelling reveals the compartmental proteome of murine sensory neurons
Sondermann, J. R.; Barry, A. M.; Xian, F.; Haberl, T.; Gomez-Varela, D.; Benseler, F.; Schreiner, D.; Lipstein, N.; Brose, N.; Schmidt, M.
10.1101/2025.06.13.659475 — neuroscience — Posted on 2025-06-15
15 Label-free structural imaging of plant roots and microbes using third-harmonic generation microscopy
Pan, D.; Rivera, J. A.; Miao, M.; Kim, P.; Tyml, T.; Rodriguez, C.; Afifa, U.; Wang, B.; Yoshikuni, Y.; Elisabeth, N. H.; Northen, T.; Vogel, J. P.; Ji, N.
10.1101/2024.04.13.589377 — plant biology — Posted on 2025-06-15
16 Hepatic ADMA/PRMT1 axis regulation is associated with NO-dependent endothelial dysfunction in MASH
Lallement, J.; Bott, S.; Esfahani, H.; Serafimov, K.; Henderson, M.; Benoit, Z.; Dumas, L.; Al-Siyabi, S.; Feron, O.; Leclercq, I. A.; Dessy, C.
10.1101/2025.06.10.658894 — physiology — Posted on 2025-06-15
19 Bringing the Genetically Minimal Cell to Life on a Computer in 4D
Thornburg, Z. R.; Maytin, A.; Kwon, J.; Brier, T. A.; Gilbert, B. R.; Fu, E.; Gao, Y.-L.; Quenneville, J.; Wu, T.; Li, H.; Long, T.; Pezeshkian, W.; Sun, L.; Glass, J.; Mehta, A.; Ha, T.; Luthey-Schulten, Z.
10.1101/2025.06.10.658899 — biophysics — Posted on 2025-06-15
22 TRPV4 Inhibition Reduces Cartilage Growth During Axolotl Limb Regeneration
Kondiboyina, V.; Miller, M.; Ritterbuck, M.; Owen, A.; Duerr, T. J.; Monaghan, J. R.; Shefelbine, S. J.
10.1101/2025.06.10.658903 — bioengineering — Posted on 2025-06-15
23 Bipartite chromatin recognition by Hop1 from two diverged holozoa
Rodriguez, A. A.; Cirulli, A. E.; Chau, K.; Nguyen, J.; Ye, Q.; Corbett, K. D.
10.1101/2025.06.14.659699 — biochemistry — Posted on 2025-06-15
24 A high-affinity split-HaloTag for live-cell protein labeling
Lin, Y.-H.; Kompa, J.; Sun, D.-e.; Mao, R.; Koch, B.; Hinnah, K.; Wilhelm, J.; Franz, N.; Kühn, S.; Menche, T.; Adow, A.; Breuer, P.; Hiblot, J.; Johnsson, K.
10.1101/2025.06.15.659771 — biochemistry — Posted on 2025-06-15
26 Systematic characterization of the ovarian landscape across mouse menopause models
Kim, M.; Bhala, R.; Wang, J.; Lu, R. J.; Lee, E. H.; Alvarenga, J. L.; Williams, R. G.; Benayoun, B. A.
10.1101/2025.06.10.658920 — genomics — Posted on 2025-06-15
27 A collection of patient-derived intestinal organoid lines reveals epithelial phenotypes associated with genetic drivers of pediatric inflammatory bowel disease
Jeshvaghani, Z. S.; Argmann, C.; Mokry, M.; van Es, J.; de Vries, M.; Collen, L.; Kotlarz, D.; Sveen, M.; Comella, P.; Snapper, S.; Klein, C.; Schadt, E.; Clevers, H.; Kuijk, E.; Nieuwenhuis, E.
10.1101/2025.06.11.659052 — genetics — Posted on 2025-06-15
28 Urbanization drives genetic and plastic responses of the spotted jewelweed flower morphology
Burkiewicz, J.; Carvalho, J.; Caporgno, S.; Lafond, J.; Devaux, C.; Normandin, E.; Joly, S.
10.1101/2025.06.10.658901 — evolutionary biology — Posted on 2025-06-15
29 Spatial and temporal patterns of colony density and habitat associations of a small desert ant
Cao, A. L.; Milesi, F. A.; Pol, R. G.; Vullo, L.; Miretti, M. F.; Pirk, G. I.; Lopez de Casenave, J.
10.1101/2025.06.10.658907 — ecology — Posted on 2025-06-15
30 Plasma membrane rather than endosomal Gq signaling drives transcriptional activity by the viral chemokine receptor US28 in glioblastoma
Daly, C.; Wright, A.; Heukers, R.; McKee, C. M.; Coll, R. C.; Evergren, E.; Smit, M. J.; Thomsen, A.; Plouffe, B.
10.1101/2025.06.12.659276 — cell biology — Posted on 2025-06-15
33 High-resolution spatial mapping of cell state and lineage dynamics in vivo with PEtracer
Koblan, L. W.; Yost, K. E.; Zheng, P.; Colgan, W. N.; Jones, M. G.; Yang, D.; Kumar, A.; Sandhu, J.; Schnell, A.; Sun, D.; Ergen, C.; Saunders, R. A.; Zhuang, X.; Allen, W. E.; Yosef, N.; Weissman, J. S.
10.1101/2025.06.15.659774 — molecular biology — Posted on 2025-06-15
34 Activin receptor type IIA/B blockade increases muscle mass and strength, but compromises glycemic control in mice
Carlsson, M.; Larsen, E. H. F.; Marmol, J. M.; Ali, M. S.; Raun, S. H.; Battey, E.; Andersen, N. R.; Irazoki, A.; lund, C.; Henriquez-Olguin, C.; Hoejfeldt, M. H.; Blomquist, P.; Bromer, F. D.; Lodberg, A.; Andersen, C. B. F.; Eijken, M.; Knudsen, J. R.; Richter, E. A.; Sylow, L.
10.1101/2025.06.11.659035 — molecular biology — Posted on 2025-06-15
36 Ovarian Cancer Drives TLR5-Dependent Expansion of Myeloid Progenitors Through Systemic Dissemination of Ligands
Kolli, S. H.; McGinty, M. T.; Putelo, A. M.; Hatzinger, C. N.; Bajgai, S.; Poblete, M. K.; Thompson, B.; Feng, T.-Y.; Azar, F. N.; Mirani, A.; Petri, W.; Burgess, S. L.; Rutkowski, M. R.
10.1101/2025.06.10.658497 — immunology — Posted on 2025-06-15
40 Canagliflozin reprograms the aging hippocampus in genetically diverse UM-HET3 mice and attenuates Alzheimer's-like pathology
Jayarathne, H. S.; Manchanayake, D. H.; Chimienti, N.; Kadri, O.; Gurdziel, K.; Kim, S.; Jang, H.; Ginsburg, B. C.; Miller, R. A.; Yakar, S.; Sadagurski, M.
10.1101/2025.06.10.658747 — neuroscience — Posted on 2025-06-15
42 Two Specialized Intrinsic Cardiac Neuron Types Safeguard Heart Homeostasis and Stress Resilience
Xu, Q. J.; Applegate, M. C.; Hsu, I.-U.; Kogan, R. P.; Hafez, O. A.; Wang, R. L.; Rios Coronado, P. E.; Young, L. H.; Zeng, X.; Zhang, L.; Chang, R.
10.1101/2025.06.13.659555 — neuroscience — Posted on 2025-06-15
43 Increased Synapse Elimination by Inflammatory Cells Contributes to Long-lasting Post-Stroke Memory Dysfunction in Old Mice
Shabani, Z.; Pan, P.; Li, Q.; Wang, Z.; Leng, K.; Sangras, S.; Huo, K.; Yadav, A.; Wang, C.; Shi, J.; Chinn, G.; Kyritsis, N.; Ferguson, A. R.; Hellman, J.; Su, H.
10.1101/2025.06.13.659591 — neuroscience — Posted on 2025-06-15
44 The vagus nerve promotes memory via septo-hippocampal acetylcholine: Implications for obesity-induced cognitive dysfunction
Tierno Lauer, L.; Decarie-Spain, L.; Hayes, A. M. R.; Suarez, A. N.; Bashaw, A. G.; Klug, M. E.; Kao, A. E.; Cheng, R.; Rea, J. J.; Subramanian, K. S.; Nourbash, A. C.; Donohue, K. N.; Schier, L. A.; Myers, K. P.; Kanoski, S. E.
10.1101/2025.06.11.659206 — neuroscience — Posted on 2025-06-15
45 Sex-dependent effects of maternal high-fat diet during lactation in adult THY-Tau22 mice offspring
Gauvrit, T.; Benderradji, H.; Pelletier, A.; Carvalho, K.; Aboulouard, S.; Faivre, E.; Chatelain, E.; Cannafarina, H.; Labous, L.; Launay, A.; Fourcot, M.; Kwiatkowski, D.; Chesnais, L.; Vallez, E.; Cardon, T.; Deleau, A.; Thiroux, B.; Eddarkaoui, S.; Bogdanova, A.; Besegher, M.; Delahaye, F.; Annicotte, J.-S.; Le Gras, S.; Tailleux, A.; Salzet, M.; Marot, G.; Buee, L.; Blum, D.; Vieau, D.
10.1101/2025.06.10.658847 — neuroscience — Posted on 2025-06-15
46 Generation of knock-in Cre and FlpO mouse lines for precise targeting of striatal projection neurons and dopaminergic neurons
Albarran, E.; Fushiki, A.; Nelson, A.; Ng, D.; Chaimowitz, C.; Nikoobakht, L.; Sippy, T.; Peterka, D. S.; Costa, R. M.
10.1101/2025.06.15.659794 — neuroscience — Posted on 2025-06-15
49 Supervised white matter bundle segmentation in glioma patients with transfer learning
Riccardi, C.; Coletta, L.; Ghezzi, S.; Amorosino, G.; Zigiotto, L.; Jovicich, J.; Sarubbo, S.; Avesani, P.
10.1101/2025.06.13.659452 — neuroscience — Posted on 2025-06-15
50 Post-translational modifications distinguish amyloid-β isoform patterns extracted from vascular deposits and parenchymal plaques
Koutarapu, S.; Roberts, K. F.; Coyle, R. A.; Mehla, J.; Sato, C.; Zipfel, G. J.; Bateman, R. J.; Schwetye, K. E.; Mukherjee, S.
10.1101/2025.06.11.658821 — neuroscience — Posted on 2025-06-15
52 Astrocytes control motor neuronal mitochondrial axonal transport deficits in C9ORF72 ALS.
Stavrou, M.; Heffernan, A.; Carter, R. N.; Dando, O.; Jiwaji, Z.; Burr, K.; Nanda, J.; Cholewa, J.; Story, D.; Hardingham, G.; Selvaraj, B.; Chandran, S.
10.1101/2025.06.10.658820 — neuroscience — Posted on 2025-06-15
53 Problem-solving without a cortex: inferior lobe drives goal-directed object manipulation in cichlid fish
Estienne, P.; Page, G.; Poon, G.; Larrat, B.; Durier, T.; Dufresne, A.; Ciobanu, L.; Yamamoto, K.
10.1101/2025.06.10.658878 — neuroscience — Posted on 2025-06-15
54 Challenges in Replay Detection by TDLM in Post-Encoding Resting State
Kern, S.; Nagel, J.; Wittkuhn, L.; Gais, S.; Dolan, R. J.; Feld, G. B.
10.1101/2025.06.11.658835 — neuroscience — Posted on 2025-06-15
56 Mapping of individual somatosensory representations - comparison of fMRI and TMS
Gogulski, J. D.; Nyrhinen, M.; Zetter, R.; Tokariev, M.; Lin, H.; Pertovaara, A.; Carlson, S.
10.1101/2025.06.12.659279 — neuroscience — Posted on 2025-06-15
58 Modulation of SLP-2 expression protects against alpha-synuclein neuropathology by mitigating mitochondrial dysfunction
Bolduc, C.; Castelo Rueda, M. P.; Lorente Picon, M.; Gentile, G.; Kalvakuri, S.; Soto Linan, V.; Zanon, A.; Laouafa, S.; Lang, M.; Lavdas, A. A.; Gilmozzi, V.; Bernardo, G.; Coulombe, V.; Gora, C.; Peralta, M.; Rioux, V.; Honisch, C.; Pramstaller, P. P.; Ruzza, P.; Ziviani, E.; Bodmer, R.; Hicks, A. A.; Parent, M.; Soliz, J.; Joseph, V.; Pichler, I.; Levesque, M.
10.1101/2025.06.13.659577 — neuroscience — Posted on 2025-06-15
59 An intracortical brain-machine interface based on macaque ventral premotor activity
De Schrijver, S.; Ramirez, J. G.; Iregui, S.; Aertbelien, E.; De Schutter, J.; Theys, T.; Decramer, T.; Janssen, P.
10.1101/2025.06.11.659174 — neuroscience — Posted on 2025-06-15
62 A systemic clock brake: Period1 stabilizes the circadian network under environmental stress
Kim, P.; Kumar, V.; Garner, N.; Jayasinghe, O.; Roman, G.; Walters, S.; Vo, T. Q. A.; Nguyen, Q.; Bowles, J.; Woodruff, T. M.; Inder, W.; Hunt, J.; Heyde, I.; Oster, H.; Rawashdeh, O.
10.1101/2025.06.12.659230 — neuroscience — Posted on 2025-06-15
63 RubyACRs Enable Red-Shifted Optogenetic Inhibition in Freely Behaving Drosophila
Bushey, D.; Shiozaki, H. M.; Shuai, Y.; Zheng, J.; Jayaraman, V.; Kolb, I.; Hasseman, J. P.; GENIE Project Team, ; Turner, G. C.
10.1101/2025.06.13.659144 — neuroscience — Posted on 2025-06-15
66 Cryo-EM Structure of Photosystem I from mangroves in their natural environment
Malavath, T.; Heilmann, E.; Charras, Q.; Yuan, X.; Al-Amoudi, A.; Naschberger, A.; Gholami, A.
10.1101/2025.06.10.658896 — plant biology — Posted on 2025-06-15
67 Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging
De Man, R.; Cai, Z.; Doddaballapur, P.; Guerrera, N.; Lin, L.; Justet, A.; Abu Hussein, N. S.; Cavinato, C.; Raredon, M. S. B.; Heerdt, P.; Singh, I.; Yan, X.; Kang, M.-J.; Bruns, D. R.; Lee, P. J.; Tellides, G.; Humphrey, J.; Kaminski, N.; Ramachandra, A. B.; Manning, E. P.
10.1101/2025.06.10.658632 — physiology — Posted on 2025-06-15
70 Constrained template matching using rejection sampling
Maurer, V. J.; Grunwald, L.; Kennes, D. M.; Kosinski, J.
10.1101/2025.06.10.658890 — biophysics — Posted on 2025-06-15
71 Encapsulation-enhanced genetic switches in lactobacilli
Blanch-Asensio, M.; Tadimarri, V. S.; Martinez, R. P.; Dahiya, G. S.; Duong, C. N.; Lale, R.; Sankaran, S.
10.1101/2025.01.10.632477 — bioengineering — Posted on 2025-06-15
73 Desert Hedgehog mediates stem Leydig cell differentiation through Ptch2/Gli1/Sf1 signaling axis
Zhao, C.; Chen, Y.; Liu, L.; Liu, X.; Xiao, H.; Wang, F.; Huang, Q.; Dai, X.; Tao, W.; Wang, D.; Wei, J.
10.1101/2025.06.13.659479 — developmental biology — Posted on 2025-06-15
75 The Staphylococcus aureus prophage-encoded SSBP attenuates virulence and enhances IL-6-mediated macrophage clearance
Ahmad-Mansour, N.; Abi Najem, C. N.; Martin, M.; Plumet, L.; Huc-Brandt, S.; Morsli, M.; Francois, P.; Sotto, A.; Dunyach-Remy, C.; Lavigne, J.-P.; MOLLE, V.
10.1101/2025.03.13.643069 — microbiology — Posted on 2025-06-15
76 An archaeal CBASS system eliminates viruses without killing the host cells
Choudhary, D. K.; Singla, H.; Vassover, D.; Golan, N.; Reshef, L.; Shukrun, H.; Gophna, U.
10.1101/2024.09.12.612678 — microbiology — Posted on 2025-06-15
77 The capsule and genetic background, rather than specific individual loci, strongly influence in vitro pneumococcal growth kinetics
Chaguza, C.; Arends, D. W.; Lo, S. W.; Putri, I. H.; York, A.; Lees, J. A.; Wyllie, A. L.; Weinberger, D. M.; Bentley, S. D.; de Jonge, M. I.; Cremers, A. J. H.
10.1101/2024.12.05.627025 — microbiology — Posted on 2025-06-15
78 Multiplexed Neuromodulatory-Type-Annotated EM-Reconstruction of Larval Zebrafish
Li, F.-n.; Liu, J.-z.; Shi, C.; Yuan, J.-b.; Lv, Y.-n.; Liu, J.; Zhang, L.-n.; Li, L.-l.; Shen, L.-j.; Chen, X.; Zhai, H.; Chen, B.-h.; Zhang, Y.-c.; Chen, H.-r.; Yan, H.-y.; Chang, S.; Ma, H.-t.; Zhou, F.-x.; Xin, T.; Dong, X.-h.; Lin, L.-m.; Zhao, X.-h.; Fang, Z.-h.; Zu, J.-l.; Tao, R.-k.; Hu, H.-y.; Qian, C.-y.; Wang, Y.-s.; Zhang, C.-m.; Xiang, P.-s.; Yang, Y.-x.; Du, X.-f.; Han, H.; Du, J.-l.
10.1101/2025.06.12.659365 — neuroscience — Posted on 2025-06-15
80 Long-term Nrf2-driven microglial repopulation mitigates microgliosis, neuronal loss and cognitive deficits in tauopathy
Viqueira, L.; Navarro, E.; Negredo, P.; Bernal, J. A.; Rodriguez-Franco, M. I.; Tortosa, E.; Lopez, M. G.
10.1101/2025.06.11.659019 — neuroscience — Posted on 2025-06-15
81 Viral Infection Induces Alzheimer's Disease-Related Pathways and Senescence in iPSC-Derived Neuronal Models
Hribkova, H.; Pospisilova, V.; Amruz Cerna, K.; Vanova, T.; Haviernik, J.; Sedmik, J.; Bernatik, O.; Olha, J.; Raska, J.; Ruzek, D.; Sheardova, K.; Vajrychova, M.; Gresova, K.; Cesnarikova, S.; Satkova, M.; Plesingrova, K.; Maragkakis, M.; Strakova, P.; Fortova, A.; Sadibolova, M.; Kupcik, R.; Fabrik, I.; Bohaciakova, D.
10.1101/2025.06.11.659008 — neuroscience — Posted on 2025-06-15
85 Overnight circuit remodelling drives juvenile alloparental care
Jamieson, B. B.; Chen, M. X.; Liang, S.; El Rasheed, L. S. H.; Chattey, G. M. K.; Kohl, J.
10.1101/2025.06.13.659524 — neuroscience — Posted on 2025-06-15
86 FiPhoPHA - A fiber photometry python package for post-hoc analysis
Drakopoulos, V.; Reichenbach, A.; Stark, R.; Foldi, C. J.; Jean-Richard-dit-Bressel, P.; Andrews, Z. B.
10.1101/2025.06.12.659422 — neuroscience — Posted on 2025-06-15
87 Aβ-HMGB1 complex is a pathogenic molecule at the advanced stage of Alzheimer's disease
Tanaka, H.; Homma, H.; Yoshioka, Y.; Fujita, K.; Yamada, S.; Furukawa, K.; Ishiki, A.; Atsuta, N.; Waragai, M.; Mano, T.; Katsuno, M.; Sobue, G.; Arai, H.; Iwata, A.; Okazawa, H.
10.1101/2025.06.12.659430 — neuroscience — Posted on 2025-06-15
88 Selective-plane Functional Ultrasound Neuroimaging
Waasdorp, R.; Gouwerok, T.; Munoz-Ibarra, E.; Nelissen, F.; Gazzola, V.; Renaud, G. G. J.; Maresca, D.; Heiles, B.
10.1101/2025.06.12.659275 — neuroscience — Posted on 2025-06-15
89 Sleep strengthens successor representations of learned sequences
He, X.; Büchel, P. K.; Faghel-Soubeyrand, S.; Klingspohr, J.; Kehl, M. S.; Staresina, B. P.
10.1101/2025.06.11.658893 — neuroscience — Posted on 2025-06-15
90 Response dynamics of discrete subiculum->retrosplenial cortex projections underlying trace fear conditioning
Bassett, T. E.; Wang, Y.-Z.; Wood, E. M.; Zhang, H.; Petrovic, Z.; Prifti, V.; Jovasevic, V.; Yamawaki, N.; Ren, L.; Khalatyan, N.; Grayson, V.; Savas, J. N.; Radulovic, J.; Cicvaric, A.
10.1101/2025.06.12.659393 — neuroscience — Posted on 2025-06-15
91 Characterization of neuronal ensembles in a model of dual reward conditioned place preference
Flom, L. T.; Sandum, K.; Hodgins, S.; Johnson-Noya, S.; Crouse, J.; Zhang, Z.; Bobadilla, A. C.
10.1101/2025.06.11.659163 — neuroscience — Posted on 2025-06-15
93 Induction of Human Pruriceptors from Pluripotent Stem Cells via Transcription Factors
Iriki, H.; Hu, R.; Li, X.; Baljinnyam, E.; Habich, C.; Imanishi, I.; Miller, L.; Chegireddy, K.; Malik, L. I.; Yassky, D.; Heul, A. V.; Smith, K. M.; Goedken, E. R.; Reinhardt, P.; Kim, B. S.; Marro, S. G.
10.1101/2025.06.11.659208 — neuroscience — Posted on 2025-06-15
95 GPR68, a proton-sensing GPCR, mediates acid-induced visceral nociception
Paine, L. W.; Gupta, R.; Higham, J.; Aguilera-Lizarraga, J.; Ritoux, A.; Pritchard, T.; Nicholson, S.; Hockley, J.; Raine, T.; Hausmann, M.; Bednar, K.; Rogler, G.; Welsh, F.; Smith, E. S. J.; Bulmer, D.
10.1101/2025.06.13.659465 — neuroscience — Posted on 2025-06-15
97 Arousal-Driven Serial Dependence: Internal States Modulate Perceived Duration
Cheng, S.; Jin, W.; Shan, X.; Kara, E. B.; Bilgic, S. E.; Salomasova, S.; Unterguggenberger, Q.; Shi, Z.
10.1101/2025.06.15.659791 — neuroscience — Posted on 2025-06-15
98 DCPS modulates TDP-43 mediated neurodegeneration through P-body regulation
Ye, Y.; Zhang, Z.; Yu, X.; Zhu, C.; Wright, N.; Asbury, J.; Huang, Y.; Wang, W.; Gomez-Isaza, L.; Troncoso, J.; He, C.; Sun, S.
10.1101/2025.06.13.659508 — neuroscience — Posted on 2025-06-15
99 Drosophila Modeling of Insomnia-Associated Genes Reveals Diverse Underlying Sleep Phenotypes
Mandigo, T. R.; Abou Daya, F.; Math, S.; Ye, A. Q.; Maher, M.; Saxena, R.; Walker, J. A.
10.1101/2025.06.12.659376 — neuroscience — Posted on 2025-06-15
100 Shared Neural Signatures of Socioeconomic Status, Scarcity, and Neighborhood Threat in Youth
Brosch, K.; Wiersch, L.; Christensen, E.; Rakesh, D.; Hanson, J.; Schwartz, R. M.; Dhamala, E.
10.1101/2025.06.11.659188 — neuroscience — Posted on 2025-06-15
102 iSleep: Continuous, binocular pupil tracking in sleep and reduced consciousness for physiological monitoring, predictions and interventions
Yuzgec, O.; Legendre, G.; Asadian, A.; Gloria, Y.; Bayer, L.; Tourdot, Q.; Pellat, S.; Novozhilova, S.; D'Ancona, C.; Ulanova, M.; Kecik, M.; Maccari, A.; Lopez, D.; Licini, L.; Nguyen Tang, G.; Van Delden, S.; Bravetti, G. E.; Vo, T.; Kropp, M.; Boex, C.; Jakus, L.; Schaller, K.; Sollander, F.; Vutskits, L.; Thumann, G.; Schwartz, S.; Huber, D.
10.1101/2025.06.13.659058 — neuroscience — Posted on 2025-06-15
103 Intrinsically disordered regions facilitate Msn2 target search to drive promoter selectivity
Strugo, N.; Burstein, C.; Hossain, S. S.; Nago, N.; Goldsmith, M.; Khamis, H.; Kaplan, A.
10.1101/2025.05.23.654710 — biophysics — Posted on 2025-06-15
104 Investigating diurnal effects and joint nest defense behavior in Herring Gulls
Shah, S. S.; Ellms, M. E.; Dygean, F.; Gunasekera, S.; Hart, E.; Ivanyi, R. E.; Lane, M.; Liu, D.; Pitcher, D.; Saucier, A.; Schroeder, K. F.; Triquet, J.; Williams, K.; Covino, K. M.
10.1101/2025.06.13.659635 — animal behavior and cognition — Posted on 2025-06-15
108 Single-cell omics reveal distinct gene regulatory dynamics underpinning embryonic and extraembryonic lineage functions during pig blastocyst development
Dufour, A.; Rossignol, M.-N.; Manceau, P.; Bailly, Y.; Ferchaud, S.; Mercat, M.-J.; Turhan, A. G.; Djebali, S.; Foissac, S.; Artus, J.; Acloque, H.
10.1101/2025.06.15.657618 — developmental biology — Posted on 2025-06-15
109 Major waves of H2A.Z incorporation during mouse oogenesis
Fosslie, M.; Ilaslan, E.; Skuland, T.; Manaf, A.; Soegaard, M. L. C.; Indahl, M.; Vera-Rodriguez, M.; Suganthan, R.; Jermstad, I.; Khanam, S.; Dalen, K. T.; Eskeland, R.; Choudalakis, M.; Bjoras, M.; Fedorcsak, P. Z.; Greggains, G. D.; Zagrobelny, M.; Dahl, J. A.; Lerdrup, M.
10.1101/2025.06.14.659461 — developmental biology — Posted on 2025-06-15
110 Quantitative Proteomics Links Mitochondrial Dysfunction to Metabolic Changes and Epithelial Differentiation Defects in Hyperoxia-Exposed Neonatal Airway Cells
Ganguly, A.; Carter, C. M.; Negron, A. R.; Zhong, H.; Moreira, A.; Walters, M. S.; Rogers, L. K.; Prakash, Y. S.; Tipple, T. E.; Richardson, A.
10.1101/2025.06.15.659571 — developmental biology — Posted on 2025-06-15
111 Effects of Ambient Temperature During Pregnancy on Newborn Birthweight
Nargund, R.; Marchesoni, J.; Bareja, A.; W. Sosnowski, D.; Peng, G.; Hoyo, C.; Pan, W.; K. Murphy, S.
10.1101/2025.06.10.658978 — developmental biology — Posted on 2025-06-15
115 Neurons, Muscles, and Venom: Identifying Drivers of Cephalopod Predation
Kirchhoff, K. N.; Williams, M.; Stambouli, B.; Pardo-Blas, J. R.; Courtney, A.; Sugarman, A. L.; Vanselow, D. J.; Carrasco, C.; Cuddy, C.; Schafer, W. R.; Cheng, K. C.; Seuntjens, E.; Holford, M.
10.1101/2025.06.15.659772 — neuroscience — Posted on 2025-06-15
117 Cholesterol Inhibits HCN Channels through Dual Mechanisms in Neuropathic Pain
Handlin, L. J.; Giere, C.; Dumaire, N. L.; Salih, L.; Moutal, A.; Dai, G.
10.1101/2025.06.15.659789 — neuroscience — Posted on 2025-06-15
119 Human placental stem cells induce a novel multiple myeloid cell-driven immunosuppressive program that ameliorates proinflammatory CNS pathology
Sarlus, H.; Guo, Y.; Bencina, S.; Zhu, K.; Joshua, V.; Virgilio, G. A.; Cheng, Y.; Lin, J.; Min, J. H.; Cuesta, I. B.; Suerth, V.; Alonso, P. T.; Thomas, O. G.; Rykaczewska, U.; Cacais, A. O. G.; Jagodic, M.; Gramignoli, R.; Harris, R. A.
10.1101/2025.06.14.659704 — neuroscience — Posted on 2025-06-15
127 RpS12-mediated induction of the Xrp1short isoform links ribosomal protein mutations to cell competition
Potiri, M.; Tsakiri, E.; Kontogiannidi, K.; Loizou, M.; Skoulakis, E. M. C.; Samiotaki, M.; Kafasla, P.; Kiparaki, M.
10.1101/2025.06.15.659587 — developmental biology — Posted on 2025-06-15
128 The nucleus forms a dynamic contact with the plasma membrane to maintain the glandular epithelial architecture
Rayer, M. S.; Mui, K.; Pendyala, K.; Rockenbach Zenzen, J. A.; Antoku, S.; Lele, T.; Gundersen, G. G.
10.1101/2025.06.13.659552 — cell biology — Posted on 2025-06-15
129 Treatment with the ribosome biogenesis inhibitor CX-5461 increases platelet count in humans and enhances murine megakaryopoiesis
Bhoopalan, V.; Kaur, A.; Hearn, J. I.; Maclachlan, K. H.; Liu, L.; Ferreira, R.; Ali, S. A.; Thong, Y. L.; Hein, N.; Nazir, S.; Brysland, S. A.; Man, S. M.; Harrison, S. J.; Andrews, R. K.; Eto, K.; Choi, P. Y.-I.; Wen, J.; Hannan, K. M.; Hannan, R. D.; Gardiner, E. E.
10.1101/2025.06.15.659730 — cell biology — Posted on 2025-06-15
130 Oviduct fluid metabolic regulation of embryonic genome methylation
Fuego, D. M.; Devkota, I.; Bonomo, Z. L.; Li, Y.; Zhang, X.; Dondeti, M. F.; Donnarumma, F.; Matsakas, A.; Patterson, A. L.; Williams, C. C.; Vourekas, A.; Fu, X.; Bondioli, K. R.; Simintiras, C. A.
10.1101/2025.06.13.659599 — cell biology — Posted on 2025-06-15
131 Ciliary and non-ciliary functions of CEP104 in Xenopus
Louka, P.; Potamiti, L.; Panayiotidis, M. I.; Skourides, P.
10.1101/2025.06.12.659327 — cell biology — Posted on 2025-06-15
132 Condensate-driven chromatin organization via elastocapillary interactions
Zhao, H.; Strom, A. R.; Eeftens, J. M.; Haataja, M.; Kosmrlj, A.; Brangwynne, C. P.
10.1101/2025.06.12.659369 — biophysics — Posted on 2025-06-15
134 Mechanochemical feedback between confinement and actin crosslinking drives the shape dynamics of liquid-like droplets
Mansour, D.; Jordan, D.; Walker, C.; Chandrasekaran, A.; Lee, C. T.; Graham, K.; Stachowiak, J.; Rangamani, P.
10.1101/2025.06.13.659650 — biophysics — Posted on 2025-06-15
136 Nutritional iron deficiency elicits profound rewiring of red pulp macrophage functions via high FPN and SYK-mediated signaling
Mandal, P. K.; Chouhan, K.; Slusarczyk, P.; Mahadeva, R.; Zurawska, G.; Niklewicz, M.; Jonczy, A.; Lenartowicz, M.; Pokrzywa, W.; Meynard, D.; Nemeth, E.; Mleczko-Sanecka, K.
10.1101/2025.06.13.659526 — cell biology — Posted on 2025-06-15
139 Proof-of-Concept in a Murine Model of Treatment of Thrombotic Thrombocytopenic Purpura Using Engineered Red Blood Cells
Roberts, K. S.; Zhang, S.; Batbayar, K.; Yan, Z.; Muia, J.; Mulvey, J. J.; Olivier, E.; Pullman, J. M.; Cataland, S. R.; Bouhassira, E. E.
10.1101/2025.06.12.659386 — cell biology — Posted on 2025-06-15
141 Functional rescue of a fatal ERAD mutation via alternative splicing
Wang, H.; Wang, Z.; Lin, L.; Verma, S.; Gniadzik, W.; Wang, H.; Li, Z.; Jiang, L.; Kuyumcu-Martinez, M.; Sun, S.; Qi, L.
10.1101/2025.06.13.659581 — cell biology — Posted on 2025-06-15
142 The nucleus activates mechano-responsiveness via FHOD-associated LINC complexes
Antoku, S.; Gundersen, G. G.; Worman, H. J.; Morrow, J. P.; Joseph, L. C.; Fine, B. M.; Zhang, X.; Kushner, J.; Lin, C.-S.; Schwartz, T.; Dabhade, P.
10.1101/2025.06.13.659598 — cell biology — Posted on 2025-06-15
144 Occludin Acts as a Dynein Adaptor Regulating Permeability and Collateral Angiogenesis
Liu, X.; Su, E. J.; Dreffs, A.; Gillies, J. P.; Merlino, M.; Gao, L.; Peregoff, J. S.; Lin, C.-m.; Ross, M. E.; DeSantis, M. E.; Lawrence, D. A.; Antonetti, D. A.
10.1101/2025.06.12.659326 — cell biology — Posted on 2025-06-15
145 PB-scope: Contrastive learning of dynamic processing body formation reveals undefined mechanisms of approved compounds
Shen, D.; Zhu, Q.; Pang, X.; Yang, X.; Pan, D.; Zhang, M.; Li, Y.; Sun, Z.; Fang, L.; Chen, W.; Tsuboi, T.
10.1101/2025.06.14.659731 — cell biology — Posted on 2025-06-15
146 Native, Spatiotemporal Profiling of the Global Human Regulome
Pino, L. K.; Canzani, D.; Gutierrez, A.; Hubbard, E.; Broderick, E.; Prymolenna, A.; Mercenne, G.; Siebenthall, K.; Fondrie, W. E.; Robbins, J.; McEllin, B.; Takta, L.; Paez, J. S.; Federation, A. J.
10.1101/2025.06.14.659727 — cell biology — Posted on 2025-06-15
147 The role of amygdala calcitonin gene-related peptide receptors on the development of persistent bladder pain in mice.
Lewter, L. A.; Paul, B. K.; Salazar, A. M.; Chatterjee, U. R.; Pham, H. P. T.; Khan, M. Z.; Schmitz, A. E.; Nofal, A. M.; Hussein, M. M.; Mysorekar, I. U.; Kolber, B. J.
10.1101/2025.06.10.658965 — neuroscience — Posted on 2025-06-15
148 A connectomic resource for neural cataloguing and circuit dissection of the larval zebrafish brain
Petkova, M. D.; Januszewski, M.; Blakely, T.; Herrera, K. J.; Schuhknecht, G. F. P.; Tiller, R.; Choi, J.; Schalek, R. L.; Boulanger-Weil, J.; Peleg, A.; Wu, Y.; Wang, S.; Troidl, J.; Kumar Vohra, S.; Wei, D.; Lin, Z.; Bahl, A.; Tapia, J. C.; Iyer, N.; Miller, Z. T.; Hebert, K. B.; Pavarino, E. C.; Taylor, M.; Deng, Z.; Stingl, M.; Hockling, D.; Hebling, A.; Wang, R. C.; Zhang, L. L.; Dvorak, S.; Faik, Z.; King, K. I.; Goel, P.; Wagner-Carena, J.; Aley, D.; Chalyshkan, S.; Contreas, D.; Li, X.; Muthukumar, A. V.; Vernaglia, M. S.; Tapia Carrasco, T.; Melnychuck, S.; Yan, T.; Dalal, A.; DiMarti
10.1101/2025.06.10.658982 — neuroscience — Posted on 2025-06-15
149 CTCF is crucial for decidualization of uterine stromal cells through facilitating HOXA11 expression
Yang, X.-Q.; Jiang, R.-F.; Zhang, A.-N.; Deng, Y.-M.; Tang, S.; Zhang, Q.-Y.; Xu, Y.-W.; Yang, S.-H.; Liu, J.-L.
10.1101/2025.06.10.658981 — physiology — Posted on 2025-06-15
153 Scalable expansion and hepatic zone maturation of hepatic progenitor cells from human pluripotent stem cells
Ogawa, S.; Ogawa, M.; Liu, J. C.; Dadvar, A.; Tian, B.; Zhao, X.; Fernandes, I.; Minegishi, K.; Takase, K.; Higuchi, Y.; Suemizu, H.; McGilvray, I.; MacParland, S.; Bader, G.
10.1101/2025.06.13.659636 — cell biology — Posted on 2025-06-15
154 Mitochondrial Dysfunction Drives Age-Related Degeneration of the Thoracic Aorta
Dhanekula, A. S.; Harrison, B.; Pharaoh, G.; Mattson-Hughes, A.; Tarantini, S.; Stuppard, R.; DeRoo, S.; Burke, C. R.; Hwang, B.; Pal, J. D.; Mulligan, M. S.; Marcinek, D.
10.1101/2025.06.13.659620 — cell biology — Posted on 2025-06-15
156 A bipartite, mutation-tolerant NLS regulates interaction of ΔNp63α with importin alpha, nuclear transport and transcriptional activity
De Marinis, A.; Esmaeili, S.; Swarbrick, C. M. D.; Ranno, S.; Pavan, S.; Forwood, J. K.; McSharry, B. P.; Pal, M.; Di Iorio, E.; Alvisi, G.
10.1101/2025.06.12.659319 — cell biology — Posted on 2025-06-15
158 Napping alters Functional Brain Responses in the Aged
Reyt, M.; Dourte, M.; DeHaan, S.; Deantoni, M.; Baillet, M.; Lesoinne, A.; Laloux, S.; Hammad, G.; Collette, F.; Peigneux, P.; Muto, V.; Vandewalle, G.; Bahri, M. A.; Phillips, C.; Schmidt, C.
10.1101/2025.06.10.657597 — neuroscience — Posted on 2025-06-15
159 rAAV-miniBEND: A targeted vector for brain endothelial cell gene delivery and cerebrovascular malformation modeling
Li, J.-L.; Bi, Z.; Chen, X.-j.; Ming, T.; Qiu, B.; Li, F.; Feng, Z.; Ai, D.; Zhang, T.; Wang, J.; Lin, S.; Lu, Y.; Wang, Z.; Huang, J.; Zhao, F.; Zhao, H.; Wang, Y.; Sun, W.; Ge, W.-p.
10.1101/2025.06.10.658979 — neuroscience — Posted on 2025-06-15
160 NanoBondy reacting through NeissLock anhydride allows covalent immune cell decoration
Vankayala, L. R.; Adoni, K. R.; Lim, S. Y.; Dushek, O.; Thalassinos, K.; Howarth, M. R.
10.1101/2025.06.14.659678 — synthetic biology — Posted on 2025-06-15
161 EARLY RAINY SEASON PATTERNS OF FERN DIVERSITY AND ECOLOGICAL DISTRIBUTION IN AMURUM FOREST RESERVE, JOS PLATEAU.
Tumba, C. Y.; Samuel, G.; Ibrahim, I.; Abok, C. J.; Cleophas, A. B.; Chaskda, A. A.; Diffa, A. A.
10.1101/2025.06.10.659003 — plant biology — Posted on 2025-06-15
167 Dissecting the biological impact of GBA1 mutations using multi-omics in an isogenic setting
Alvarez Jerez, P.; Wild Crea, P. A.; Patel, D.; Glasstetter, L. M.; Alvarez, C.; Makarious, M. B.; Lara, E.; Chen, Y.; Pantazis, C. B.; Paquette, K.; Malik, L.; Nalls, M. A.; Reed, X.; Singleton, A. B.; Billingsley, K. J.; Mcdonough, J. A.; Ning, G.; Skarnes, W. C.; Ryten, M.; Sidransky, E.; Cookson, M. R.; Beilina, S.; Blauwendraat, C.
10.1101/2025.06.12.656971 — genomics — Posted on 2025-06-15
168 Organ-specific isolation of hepatocyte extracellular vesicles from human plasma enables tissue-resolved proteomic and miRNA profiling
Figueiras, R.; Vagueiro, S.; G.G Kay, R.; Persia, E.; de Alwis, R.; Hijazi, R.; Davidson, B.; Sanches-Kuiper, R.; Arsene, P.; Dias, T.
10.1101/2025.06.13.658908 — molecular biology — Posted on 2025-06-15
170 PhysDock: A Physics-Guided All-Atom Diffusion Model for Protein-Ligand Complex Prediction
Zhang, K.; Ma, Y.; Yu, J.; Luo, H.; Lin, J.; Qin, Y.; Li, X.; Jiang, Q.; Bai, F.; Dou, J.; Zheng, J.; Yu, J.; Sun, L.
10.1101/2025.04.28.650887 — bioinformatics — Posted on 2025-06-15
172 Structure of endogenous Pfs230:Pfs48/45 in complex with potent malaria transmission-blocking antibodies
Bekkering, E. T.; Yoo, R.; Hailemariam, S.; Heide, F.; Ivanochko, D.; Jackman, M.; Proellochs, N. I.; Stoter, R.; van Gemert, G.-J.; Maeda, A.; Yuguchi, T.; Wanders, O. T.; van Daalen, R. C.; Inklaar, M. R.; Andrade, C. M.; Jansen, P. W.; Vermeulen, M.; Bousema, T.; Takashima, E.; Rubinstein, J. L.; Kooij, T. W.; Jore, M. M.; Julien, J.-P.
10.1101/2025.02.14.638310 — molecular biology — Posted on 2025-06-15
173 Early Postnatal Dysfunction of ACC PV Interneurons in Shank3B-/- Mice
Shih, Y.-C.; Nelson, L.; Janecek, M.; Matarazzo, M.; D'Agostino, A.; Peixoto, R. T.
10.1101/2024.10.04.616584 — neuroscience — Posted on 2025-06-15
176 Larger larval sea lamprey (Petromyzon marinus) have longer survival times when exposed to the lampricide 3-trifluoromethyl-4-nitrophenol
Nalesnik, A. M.; Martin, E. L.; Kovacs, I. S.; Johnson, C. S.; Carroll, E. I.; Jubar, A.; Hemstrom, W.; Wilkie, M. P.; Dunlop, E. S.; Sepulveda, M. S.; Johnson, N. S.; Christie, M. R.
10.1101/2025.01.10.632359 — evolutionary biology — Posted on 2025-06-15
177 Widespread loss of sleep in independently evolved populations of wild-caught cavefish
North, O.; Maza-Castaneda, L. C.; Manning, A. E.; Rastogi, A.; Gluesenkamp, A.; Gluesenkamp, L.; Swanson, N.; Hernandez-Lozano, J.; Garduno-Sanchez, M.; Diaz-Cruz, J. A.; Kowalko, J. E.; McGaugh, S. E.; Keene, A. C.; Ornelas-Garcia, P.
10.1101/2024.10.29.619241 — evolutionary biology — Posted on 2025-06-15
182 Erratic Maternal Care Induces Avoidant-Like Attachment Deficits in a Mouse Model of Early Life Adversity
MacDowell Kaswan, Z.; Bowers, C.; Teplyakov, I.; Munoz-Martin, J.; Ahmed, S.; Kaffman, L.; Giuliano, L.; Dietrich, M. O.; Kaffman, A.
10.1101/2025.06.13.659607 — neuroscience — Posted on 2025-06-15
183 Spectral Matched Filtering in the Butterfly Visuomotor System
Supple, J. A.; Cerkvenik, U.; Ilic, M.; Pirih, P.; Zkorjanc, A.; Belusic, G.; Krapp, H. G.
10.1101/2025.06.10.658887 — neuroscience — Posted on 2025-06-15
184 PhyloControl: a phylogeny visualisation platform for risk analysis in weed biological control
Chen, S. H.; Stevens, L.; Gooden, B.; Rafter, M. A.; Knerr, N.; Thrall, P. H.; Ord, L.; Schmidt-Lebuhn, A. N.
10.1101/2025.06.11.658203 — plant biology — Posted on 2025-06-15
185 Identification of CaVβ1 isoforms required for neuromuscular junction formation and maintenance
Vergnol, A.; Bourguiba, A.; Bauche, S.; Traore, M.; Gelin, M.; Gentil, C.; Pezet, S.; Saillard, L.; Meunier, P.; Lemaitre, M.; Perronnet, J.; Tores, F.; Gautier, C.; Guesmia, Z.; Allemand, E.; Batsche, E.; Pietri-Rouxel, F.; Falcone, S.
10.1101/2025.06.10.658789 — physiology — Posted on 2025-06-15
189 Generalizing animal movement predictions across landscapes: a scalable framework grounded in empirical telemetry data
Chalkowski, K.; Sack, A.; Wittemyer, G.; Miller, R. S.; Boughton, R. K.; Snow, N. P.; Beasley, J. C.; Ditchkoff, S. S.; Evans, T. S.; Gray, S. M.; Lewis, J. S.; Parsons, M. A.; Vercauteren, K. C.; Webb, S. L.; Young, J. K.; Pepin, K. M.
10.1101/2025.06.12.658668 — ecology — Posted on 2025-06-15
191 Resolving a paradox about how vision is transformed into familiarity
Bohn, S.; Hacker, C. M.; Jannuzi, B. G. L.; Meyer, T.; Hay, M.; Rust, N. C.
10.1101/2025.06.13.659490 — neuroscience — Posted on 2025-06-15
192 CCorGsDB: A Database for Clock Correlated Genes in the Mouse and Human Central Nervous Systems
Santos, J. L. A.; Pinto, V. T. B. C.; Santos, T. E. d. S.; Coimbra, D. G.; de Andrade, T. G.
10.1101/2025.06.11.659048 — neuroscience — Posted on 2025-06-15
194 Transient AMPK activation by nutrient stress of high fat diet preserves cardiac electrophysiological stability and protects against arrhythmias
Rudokas, M. W.; McKay, M.; Wu, X.; Granger, J. M.; Williams, Y.; Bogner, M.; Kang, T.; Seyfried, A.; Toksoy, Z.; Cacheux, M.; Young, L. H.; Akar, F. G.
10.1101/2025.06.11.658631 — physiology — Posted on 2025-06-15
196 AI-Guided Design and AKT3 Degradation Synergize to Enhance Bispecific and Trispecific CAR-T Cell Persistence and Overcome Antigen Escape
Ansari, M. S.; Chauhan, V.; Akhtar, A.; Chaudhary, N.; Tyagi, R.; Divya, ; Husain, K.; Singh, A.; Sharma, S.; Alam, R.; Md Shakir, ; Pracha, M.; Anjum, S.; Mohd Nadeem, ; Faizan, M. I.; Azmi, I.; Iyer, A. R.; Gupta, P.; Nafiz, M.; Ali, S.; Ud din, I. M.; Javid, M.; Kuma P, H.; Srivastava, A. K.; Mabalirajan, U.; Mathews, V.; Ramalingam, S.; Kharya, G.; Ahmad, T.
10.1101/2025.06.12.658477 — cancer biology — Posted on 2025-06-15
201 Capture-C MPRA: A high-throughput method to simultaneously characterize promoter interactions and regulatory activity
Arnould, C.; Keukeleire, P.; Inoue, F.; Cui, X.; An, K.; Murray, E.; Zhang, X.; Drmanac, R.; Peters, B.; Shendure, J.; Shen, Y.; Kircher, M.; Ahituv, N.
10.1101/2025.06.11.658967 — genomics — Posted on 2025-06-14
203 Spatial autocorrelation of species diversity and distributions in time and across spatial scales
Soria, C. D.; Ortega, G. R.; Wolke, F. J. R.; Bartak, V.; Tschernosterova, K.; Bejcek, V.; Herrando, S.; Mikulas, I.; Stastny, K.; Ueta, M.; Vorisek, P.; Keil, P.
10.1101/2025.06.13.659470 — ecology — Posted on 2025-06-15
204 Unraveling the diversity and functional potential of cyanosphere microbiomes assembled from terrestrial cyanobacteria
Palmer, B.; Couradeau, E.; Johansen, J.; Kurbessoian, T.; Ortega Carranza, J.; Stajich, J. E.; Ward, R.; Pietrasiak, N.
10.1101/2025.06.10.658773 — ecology — Posted on 2025-06-15
205 Cell type specific CaMKII activation patterns revealed by CaMKAR, a bioactivity reporter deployable in living cells
Severino, A.; Reyes Gaido, O. E.; Liu, B.; Lopez-Cecetaite, G. A.; Wei, A.-C.; Rosales-Soto, G.; Hernandez-Ochoa, E. O.; Luczak, E. D.
10.1101/2025.06.11.658946 — molecular biology — Posted on 2025-06-15
206 Teleost-specific ictacalcins exhibit similar structural organization, cation-dependent activation and transcriptional regulation as human S100 proteins
Hernandez, L.; Paris, T.; Demou, M.; Birck, C.; Begon-Pescia, C.; Rodriguez-Vidal, J. F.; Tyrkalska, S.; Bureau, C.; Gonzalez, C.; Gracia, J.; Lelievre, E.; Mulero, V.; Chi, M. N.; YATIME, L.
10.1101/2025.06.10.658860 — immunology — Posted on 2025-06-14
207 An open dataset of cerebral tau deposition in young healthy adults based on MK6240 positron emission tomography
Lam, J.; Rodriguez-Cruces, R.; Arafat, T.; Royer, J.; Chen, J.; Dascal, A.; Sahlas, E.; Pana, R.; Hopewell, R.; Hsiao, C. H.-H.; Massarweh, G.; Soucy, J.-P.; Villeneuve, S.; Caciagli, L.; Koepp, M.; Bernasconi, A.; Bernasconi, N.; Bernhardt, B.
10.1101/2025.06.13.655622 — neuroscience — Posted on 2025-06-14
210 Sexually-dimorphic neurons in the Drosophila whole-brain connectome
Deutsch, D.; Matsliah, A.; Wang, K.; Dorkenwald, S.; Mondal, A.; Burke, A.; Hebditch, J.; Gager, J.; Yu, S.-C.; Sterling, A.; MkKellar, C.; Schlegel, P.; Gerhard, S.; Sterne, G.; Costa, M.; Eichler, K.; Yin, Y.; Jefferis, G. S. X. E.; Seung, H. S.; Murthy, M.
10.1101/2025.06.10.658788 — neuroscience — Posted on 2025-06-14
211 Cocaine withdrawal enhances subthalamic reward sensitivity
Williams, M.; Vielle, C.; de Peretti, J.-L.; Tiran-Cappello, A.; Melon, C.; Awada, A.; Pelloux, Y.; Maurice, N.; BAUNEZ, C.; Degoulet, M.
10.1101/2025.06.10.658581 — neuroscience — Posted on 2025-06-14
214 Decoupling simultaneous motor imagination and execution via orthogonal ECoG neural representations
Pollina, L.; Struber, L.; de Seta, V.; Russo, E.; Karakas, S.; Chabardes, S.; Aksenova, T.; Charvet, G.; Shokur, S.; Micera, S.
10.1101/2025.06.13.659445 — neuroscience — Posted on 2025-06-14
215 Fos labels a distinct excitatory neuron ensemble for memory retrieval
Ding, N.; Sun, Q.; Wu, C.; Xiao, Y.; Li, Y.; Wang, X.; Shu, Y.; Yuan, P.
10.1101/2025.06.14.659414 — neuroscience — Posted on 2025-06-14
216 Biomarkers in cerebrospinal fluid sediments
Alsina, R.; Riba, M.; Sartorio, M.; Romera, C.; Vilaplana, B.; Prats, E.; Molina-Porcel, L.; del Valle, J.; Pelegri, C.; Vilaplana, J.
10.1101/2025.06.10.657984 — neuroscience — Posted on 2025-06-14
217 A CRISPR-CAS9 high throughput machine-learning platform for modulation of genes involved in Parkinson's disease-associated PINK1-mitophagy in iPSC-derived dopaminergic neurons
Soutar, M. P. M.; Carbone, B.; Kindalova, P.; Mehrizi, R.; Lopes, F. M.; Lam, N.; Rockliffe, A.; Braybrook, T.; Taylor, M.; Nguyen, C.; Ducotterd, F.; Reith, A. D.; Mohamet, L.; Plun-Favreau, H.
10.1101/2025.06.10.658840 — neuroscience — Posted on 2025-06-15
219 Mapping 3D Heterogeneity of Thyroid Tumors Using Micro-CTbased Radiomics
Tajbakhsh, K.; Stanowska, O.; Buljan, M.; Neels, A.; Perren, A.; Zboray, R.
10.1101/2025.06.13.658854 — pathology — Posted on 2025-06-14
220 Spatial analysis reveals a novel inflammatory tumor transition state which promotes a macrophage-driven induction of sarcomatoid renal cell carcinoma
May, A. M.; Kadomoto, S.; Williams, C.; Soupir, A. C.; The, S.; McGue, J. J.; Robinson, T.; Shelley, G.; Hayes, M. T.; Fridley, B. L.; Balasi, J. A.; Ramos Echevarria, P. M.; Dhillon, J.; Nallandhighal, S.; Acharyya, S.; Chen, L.; Aldous, J.; Schurman, N.; Baladandayuthapani, V.; Frankel, T. L.; Salami, S. S.; Manley, B. J.; Mehra, R.; Udager, A. M.; Keller, E. T.
10.1101/2025.06.12.656421 — cancer biology — Posted on 2025-06-14
221 Breaking Through Biology's Data Wall: Expanding the Known Tree of Life by Over 10x using a Global Biodiscovery Pipeline
Vince, O.; Oldach, P.; Pereno, V.; Leung, M. H. Y.; Greco, C.; Minto-Cowcher, G.; Ur-Rehman, S.; Kam, K. Y. K.; Chow, W.; Bolton, E.; Mwambingu, B. R.; Greenhalgh, N. L.; Knot, I. E.; Christoffersen, L.; Clark, M.; Pecoraro, R.; Kollasch, A. W.; Bohnuud, T.; Bakalar, M.; Lorenz, P.; Gowers, G.
10.1101/2025.06.11.658620 — genomics — Posted on 2025-06-14
224 Engineered AAV9 as in vivo gene delivery platform for the selective transduction of TME cell subsets
Demircan, M. B.; Strassheimer, F.; Zinser, L. J.; Elleringmann, P.; John, F.; Thalheimer, F. B.; Steinbach, J. P.; Oellerich, T.; Burger, M. C.; Buchholz, C. J.
10.1101/2025.06.11.658408 — bioengineering — Posted on 2025-06-14
229 Rational Generation of Monoclonal Antibodies and Intrabodies Selective for Pathogenic TDP-43
Zhao, B.; Louadi, S.; Coutts, J. A.; Gibbs, E.; Huang, M. Y.; Marina, R. J.; Aigner, S.; Alam, P.; DeMarco, M. L.; Mackenzie, I. R.; Djikstra, A. A.; Caughey, B.; Yeo, G. W.; Kaplan, J. M.; Cashman, N. R.
10.1101/2025.06.10.658846 — immunology — Posted on 2025-06-14
230 Mitochondrial Bioenergetic Failure in SLE Immunocytes: Targeting Fitness for Therapy
Yennemadi, A. S.; Jordan, N.; Diong, S.; Little, M.; Keane, J.; Leisching, G.
10.1101/2025.06.10.658845 — immunology — Posted on 2025-06-14
232 All-Atom Protein Sequence Design using Discrete Diffusion Models
Villegas-Morcillo, A.; Admiraal, G. J.; Reinders, M. J. T.; Weber, J. M.
10.1101/2025.06.13.659451 — bioinformatics — Posted on 2025-06-14
234 Cell-free RNA reveals host and microbial correlates of broadly neutralizing antibody development against HIV
Kowarsky, M.; Moufarrej, M. N.; Okamoto, J.; Xie, Y.; Neff, N. N.; Abdool Karim, S. S.; Garrett, N. J.; Moore, P. L.; Camunas-Soler, J.; Quake, S. R.
10.1101/2025.06.10.658831 — genomics — Posted on 2025-06-14
237 The metabolic kinase LKB1 shapes the enteric nervous system bymitigating the oxidative stress and p53 activity
Lucas, A.; Appaix, F.; Allard, J.; Mevel-Aliset, M.; Radu, A. G.; Fauvelle, F.; Favier, B.; Grichine, A.; Maurer, J.; Hainaut, P.; Attardi, L. D.; Billaud, M.; Torch, S.; Thibert, C.
10.1101/2025.06.10.658770 — developmental biology — Posted on 2025-06-14
238 Epigenetic regulation of cilia stability and kidney by the chromatin remodeling SWI/SNF complexes
Cheng, X.; Zhu, Q.; Ma, S.; Peng, X.; Huang, G.; Liu, g.; Zhang, W.; Zhang, Y.; Jiang, C.; Qiu, A.; Cao, Y.
10.1101/2025.06.10.658863 — developmental biology — Posted on 2025-06-14
239 Self-amplifying mRNA expression is governed by mitochondrial machinery and ACSL4
F. Tshering, L.; Wang, C.; Xiang, Q.; Kundu, S.; Solorzano, A.; Chaparro-Riggers, J.; Lin, L.; Paksa, A.
10.1101/2025.06.13.659366 — molecular biology — Posted on 2025-06-14
240 Accumulation of SA-βGal High Cells in Human Naive T Cell Compartments Reveals a Stress-Adapted, Senescent-Like State
Alexandru, A. C.; Hormazabal, G. V.; Matsui, H.; Kasler, H.; Lore, S.; Aguirre, C. G.; Roberts, A.; Heckenbach, I. J.; Tiwari, R.; Kwok, R.; Becker, S.; Verdin, E.
10.1101/2025.06.10.658841 — immunology — Posted on 2025-06-14
243 Multi-selective RAS(ON) Inhibition Targets Oncogenic RAS Mutations and Overcomes RAS/MAPK-Mediated Resistance to FLT3 and BCL2 Inhibitors in Acute Myeloid Leukemia
Popescu, B.; Jones, M. F.; Piao, M.; Tran, E.; Koh, A.; Lomeli, I.; Peretz, C. A. C.; Murad, N.; Abelson, S.; Morales, C.; Rivera, J. M.; Pikman, Y.; Cheng, M. L.; Logan, A. C.; Stieglitz, E.; Smith, C. C.
10.1101/2025.06.10.658786 — cancer biology — Posted on 2025-06-14
244 A computational analysis of the glycoprotein LRP1 structure and the role of glycans as quaternary glue
Tuveri, G. M.; Basile, M.; Acosta Gutierrez, S.; Kausas, M.; Tian, X.; Franzese, G.; Ruiz Perez, L.; Battaglia, G.
10.1101/2025.06.10.658798 — biophysics — Posted on 2025-06-14
247 Local optogenetic control of genome editing and tumorigenesis in vivo using wireless implantable optoelectronics
Bansal, T.; Lee, M.-K.; Coleman, C.; Kim, Y.-M.; Chen, Y.; Haney, C. R.; David, O.; Sreekanth, V.; Avila, R.; Matsche, J.; Vijeth, S.; Hintermueller, D.; Yamagishi, K.; Kang, J.; Mowry, K.; Kim, M.; Liu, Y.; Toth, P. T.; Lee, S. S.-Y.; Loh, S.; Clark, S.; Huynh, H.; Kim, Y.; Banks, A. R.; Huang, Y.; Good, C. H.; Rehman, J.; Rogers, J. A.; Karginov, A. V.
10.1101/2025.06.12.659214 — bioengineering — Posted on 2025-06-14
251 Swine reporter model for preclinical evaluation and characterization of gene delivery vectors
Campbell, J.; Korpela, D.; Han, H.; Zhao, S.; Webster, D.; Nguyen, Y. A.; Aune, R.; Dagan, H.; Milliken, R.; Watts, J.; Murthy, N.; Carlson, D.
10.1101/2025.06.13.659546 — genetics — Posted on 2025-06-14
257 Vicennial metagenomic time series unveils evolutionary dynamics of giant viruses in a freshwater ecosystem
Vasquez, Y.; Romero-Gutierrez, M. F.; Bower, R.; Rohwer, R. R.; McMahon, K.; Woyke, T.; Schulz, F.
10.1101/2025.06.13.655548 — microbiology — Posted on 2025-06-14
259 Mitochondrial calcium influx-driven bioenergetics in the dopaminergic system selectively enable drug reward
Gao, J.; Zhao, H.; Han, X.; Zeng, L.; Liu, G.; Wei, X.; Liu, C.; Wu, W.; Chen, S.; Chen, J.; Li, T.; Yin, J.; Zhou, T.; Zhang, X.-M.; Li, A.-L.; Li, T.; Pan, X.
10.1101/2025.06.10.658191 — neuroscience — Posted on 2025-06-14
262 MMP release following cartilage injury leads to collagen loss in intact tissue - a computational study
Hamada, M. A.; Eskelinen, A. A.; Kosonen, J. P.; Florea, C.; Grodzinsky, A.; Tanska, P.; Korhonen, R. K.
10.1101/2025.06.10.658780 — biophysics — Posted on 2025-06-14
269 Epigenetic reprogramming of autophagy leads to uncovering a novel therapeutic target for mutant IDH1 astrocytomas
Nunez, F. J.; Banerjee, K.; Mujeeb, A. A.; Mauser, A.; Tronrud, C. E.; Zhu, Z.; Raghuram, S.; Sheth, M. R.; Pena Agudelo, J. A.; Zelaya, J.; Taher, A.; Kadiyala, P.; Carney, S. V.; Garcia-Fabiani, M. B.; Comba, A.; Alghamri, M. S.; McClellan, B. L.; Faisal, S. M.; Nwosu, Z. C.; Hong, H. S.; Sajjakulnukit, P.; Qin, T.; Sartor, M. A.; Ljungman, M.; Welch, J. D.; Cheng, S.-Y.; Lowenstein, P. R.; Lahann, J.; Lyssiotis, C. A.; Castro, M.
10.1101/2024.03.08.584091 — cancer biology — Posted on 2025-06-14
274 Genomic comparisons shed light on the adaptive basis of brain size plasticity and chromosomal instability in the Eurasian common shrew
Thomas, W. R.; Lama, T. M.; Moreno-Santillan, D.; Farre, M.; Baldoni, C.; Abueg, L.; Balacco, J.; Fedrigo, O.; Formenti, G.; Jain, N.; Mountcastle, J.; Tilley, T.; Tracey, A.; Ray, D. A.; Dechmann, D. K. N.; von Elverfeldt, D.; Nieland, J.; Corthals, A. P.; Jarvis, E.; Davalos, L. M.
10.1101/2025.04.11.648246 — evolutionary biology — Posted on 2025-06-14
279 A global map of the Zika virus phosphoproteome reveals host-driven regulation of viral budding and cytopathogenicity
Manuelyan, I.; Schmoker, A. M.; Yount, B. L.; Eisenhauer, P.; Keller, J. I.; Gold, C.; Terino, D.; Ziegler, C. M.; Alexander, J.; Driscoll, H. E.; Hutchinson, E.; Bhella, D.; Syme, C. D.; Widman, D. G.; Heise, M. T.; Baric, R. S.; Ballif, B. A.; Botten, J. W.
10.1101/2021.11.24.469793 — microbiology — Posted on 2025-06-14
280 HIV broadly neutralizing antibody escape dynamics drive the outcome of AAV vectored immunotherapy in humanized mice
Galvez, N. M. S.; Nitido, A. D.; Yoo, S. B.; Cao, Y.; Deal, C. E.; Boutros, C. L.; MacDonald, S. W.; Soto Albrecht, Y. E.; Lam, E. C.; Sheehan, M. L.; Parsons, D.; Lin, A. Z.; Deymier, M. J.; Brady, J. M.; Moon, B.; Bullock, C. B.; Tanno, S.; Pegu, A.; Chen, X.; Liu, C.; Koup, R. A.; Mascola, J. R.; Vrbanac, V. D.; Lingwood, D.; Balazs, A. B.
10.1101/2024.07.11.603156 — microbiology — Posted on 2025-06-14
281 The Ambiguous Genetic Code of Methanogenic Archaea that Grow on Methylamines
Shalvarjian, K. E.; Chadwick, G.; Perez, P. I.; Woods, P.; Orphan, V. J.; Nayak, D. D.
10.1101/2025.06.11.659114 — microbiology — Posted on 2025-06-14
282 Clover-like object vector representations support human spatial cognition
Becu, M.; Krasovec, I. M.; Saldanha, P.; Whitlock, J.; Doeller, C. F.
10.1101/2025.04.18.649400 — neuroscience — Posted on 2025-06-14
284 Humanized Caffeine-Inducible Systems for Controlling Cellular Functions
Scheller, L.; Elia, M.; Bonati, L.; Kang, C.; Gainza, P.; Garodia, Y.; Deshpande, P.; Schmidt, J.; Georgeon, S.; Tang, L.; Correia, B.
10.1101/2025.06.13.659463 — synthetic biology — Posted on 2025-06-14
290 Development and extensive sequencing of a broadly-consented Genome in a Bottle matched tumor-normal pair
McDaniel, J. H.; Patel, V.; Olson, N. D.; He, H.-J.; He, Z.; Cole, K. D.; Gooden, A. A.; Schmitt, A.; Sikkink, K.; Sedlazeck, F.; Doddapaneni, H.; Jhangiani, S. N.; Muzny, D. M.; Gingras, M.-C.; Mehta, H.; Paulin, L. F.; Hastie, A. R.; Yu, H.-C.; Weigman, V.; Rojas, A.; Kennedy, K.; Remington, J.; Salas-Gonzalez, I.; Sudkamp, M.; Wiseman, K.; Lajoie, B. R.; Levy, S.; Jain, M.; Akeson, S.; Narzisi, G.; Steinsnyder, Z.; Reeves, C.; Shelton, J.; Kingan, S. B.; Lambert, C.; Bayabyan, P.; Wenger, A. M.; McLaughlin, I. J.; Adamson, A.; Kingsley, C.; Wescott, M.; Kim, Y.; Paten, B.; Park, J.; Violich
10.1101/2024.09.18.613544 — genomics — Posted on 2025-06-14
295 A high-fidelity in vitro model of the human intestinal epithelium
Fujii, S.; Espenschied, S. T.; Anand, V.; Bettencourt-Silva, J.; Han, Y.; Ito, G.; Koseki, A.; Kosugi, A.; Kozlowski, J.; Matsumoto, R.; Meng, S.; Mulligan, N.; Musich, R. J.; Newhall, K.; Ohshina, E.; Sekiguchi, S.; Wang, Y.; Hu, J.; Ciorba, M. A.; Sibley, L. D.; Okamoto, R.; Stappenbeck, T. S.
10.1101/2024.01.01.573838 — cell biology — Posted on 2025-06-14
296 A single amino acid variant in the variable region I of AAV capsid confers liver detargeting
Xing, R.; Xu, M.; Reil, D.; Destefano, A.; Cui, M.; Liu, N.; Liang, J.; Xu, G.; Luo, L.; Xu, M.; Zhang, F.; Tai, P. W.; Wei, Y.; Gruntman, A. M.; Flotte, T. R.; Gao, G.; Wang, D.
10.1101/2025.03.04.641478 — molecular biology — Posted on 2025-06-14
297 Stable states in an unstable landscape: microbial resistance at the front line of climate change
Cronin, D. R.; Holland-Moritz, H.; Smith, D.; Aroney, S. T. N.; Hodgkins, S.; Borton, M.; Li, Y.-F.; Zayed, A.; Healy, K.; IsoGenie Field & Analytic Teams 2010-2017, ; EMERGE Institute Coordinators, ; Tfaily, M. M.; Crill, P. M.; McCalley, C.; Wrighton, K.; Varner, R. K.; Tyson, G. W.; Woodcroft, B.; Bagby, S. C.; Ernakovich, J.; Rich, V. I.
10.1101/2025.02.07.636677 — microbiology — Posted on 2025-06-14
298 Prefrontal dopamine activity is critical for rapid threat avoidance learning
Zeidler, Z. E.; Gomez, M. F.; Gupta, T.; Shari, M.; Wilke, S. A.; DeNardo, L. A.
10.1101/2024.05.02.592069 — neuroscience — Posted on 2025-06-14
299 Neurally-informed modelling unravels a single evidence accumulation process for choices and subsequent confidence reports
Grogan, J. P.; Vermeylen, L.; Mannion, S.-L.; McCabe, C.; Monakhovych, D.; Desender, K.; O'Connell, R. G.
10.1101/2025.06.05.658071 — neuroscience — Posted on 2025-06-14
300 A Brain Reward Circuit Inhibited By Next-Generation Weight Loss Drugs
Godschall, E. N.; Gungul, T. B.; Sajonia, I. R.; Buyukaksakal, A. K.; Li, O. D.-A.; Ogilvie, S.; Keeler, A. B.; Tian, G.; Koita, O.; Shi, Y.; Deutsch, T. C. J.; Crook, M.; Zhang, Y.; Conley, N. J.; Webster, A. N.; Calhan, O. Y.; Liu, W.; Akkoub, A.; Malik, K.; West, K. I.; Michel-Le, S.; Karthikeyan, A.; van Gerven, G.; Beier, K. T.; Zweifel, L. S.; Patel, M. K.; Campbell, J. N.; Deppmann, C. D.; Guler, A. D.
10.1101/2024.12.12.628169 — neuroscience — Posted on 2025-06-14
301 CrHCF244 is required for psbA translation in Chlamydomonas reinhardtii
Wang, X.; Wang, G.; Cheramie, L. A.; Zhao, C.; Dassanayake, M.; Moroney, J. V.; Vinyard, D. J.
10.1101/2024.05.30.596694 — plant biology — Posted on 2025-06-14
305 Distinct Cellular Phenotypes of Language and Executive Decline in Amyotrophic Lateral Sclerosis
Petrescu, J.; Roque, C. G.; Jackson, C.; Daly, A.; Kang, K.; Casel, O.; Leung, M.; Reilly, L.; Eschbach, J.; McDade, K.; Gregory, J. M.; Bonneau, R.; Smith, C.; Phatnani, H.
10.1101/2025.02.26.640433 — genomics — Posted on 2025-06-14
306 Neuronal Autophagy Failure Drives α-Synuclein Transfer to Microglia to Outsource Aggregate Clearance
Chakraborty, R.; Samella, P.; Testa, V.; Montero-Munoz, J.; Nonaka, T.; Hasegawa, M.; Consiglio, A.; Zurzolo, C.
10.1101/2024.04.19.590207 — cell biology — Posted on 2025-06-14
308 The single-particle structures of a Bacterial Cyanide Dihydratase and a Fungal Cyanide Hydratase
Justo Arevalo, S.; Felice, V. V.-R.; Acuna, M. B.; Flores, K. O.; Aguilar, M. Q.; Balan, A.; Farah, C. S.
10.1101/2025.06.11.659212 — biochemistry — Posted on 2025-06-12
309 An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function
Jame-Chenarboo, Z.; Schmidt, E. N.; Crichton, M.; Takahashi-Yamashiro, K.; Lima, G. M.; Luna-Dulcey, L.; Jung, J.; Ivison, S.; St. Laurent, C. D.; Enterina, J. R.; Lin, S.-Y.; Sarkar, S.; John, R.; Nanjappa, S. G.; Malaker, S. A.; Levings, M. K.; Marth, J. D.; Derda, R.; Macauley, M. S.
10.1101/2025.06.10.658684 — biochemistry — Posted on 2025-06-12
310 High-resolution cryo-EM analysis of the therapeutic Pseudomonas phage Pa223
Hou, C.-F. D.; Bellis, N.; Lokareddy, R. K.; Branston, S.; Reid, J.; Geier, R.; Soriaga, A.; Sim, L.; Kyme, P.; Birx, D.; Lemire, S.; Cingolani, G.
10.1101/2025.06.11.659172 — biochemistry — Posted on 2025-06-12
313 Examining the Effect of Social Determinants of Health on Human Trait Heritability
Risse-Adams, O. S.; Liquori, J. L.; Sinnott-Armstrong, N.; Musharoff, S. A.
10.1101/2025.06.12.659317 — genetics — Posted on 2025-06-13
314 Species-specific responses to paleoclimatic changes and landscape barriers drive contrasting phylogeography of co-distributed lemur species in northeastern Madagascar
van Elst, T.; Schüssler, D.; Rafamantanantsoa, S. M.; Radriarimanga, T.; Rabemananjara, N. R.; Rasolofoson, D. W.; Randimbiharinirina, R. D.; Hohenlohe, P. A.; Radespiel, U.
10.1101/2025.06.11.658897 — evolutionary biology — Posted on 2025-06-13
316 Foraging competence and scrounging tolerance enhance social relationships in a socially tolerant wild primate
Karakoc, E.; Vogg, R.; Michele, M.; Petersdorff-Campen, J.; Ecker, A. S.; Kappeler, P. M.; Fichtel, C.
10.1101/2025.06.12.659242 — ecology — Posted on 2025-06-13
322 The bacterial ESCRT-III PspA rods thin lipid tubules and and increase membrane curvature through helix α0 interactions
Hudina, E.; Schott-Verdugo, S.; Junglas, B.; Kutzner, M.; Ritter, I.; Hellmann, N.; Schneider, D.; Gohlke, H.; Sachse, C.
10.1101/2025.06.13.659447 — biophysics — Posted on 2025-06-13
323 HiFIseek: gene-specific enrichment of high-impact mutations in associated genomic regions
Riudavets Puig, R.; Brorson, I. S.; O'Mahony, D.; Kristensen, V. N.; Mathelier, A.
10.1101/2025.06.12.659305 — bioinformatics — Posted on 2025-06-13
324 Human CXCL17 Activates and Binds to Fish GPR25 Orthologs
Hu, W.-F.; Wang, J.-J.; Yu, J.; Yao, J.-J.; Liu, Y.-L.; Xu, Z.-G.; Guo, Z.-Y.
10.1101/2025.06.10.658772 — biochemistry — Posted on 2025-06-13
325 Spatially-explicit genomics of An. gambiae s.l uncovers fine-scale population structure and mechanisms of insecticide resistance
Nagi, S. C.; Essandoh, J.; Ato-Egyir, N.; Lucas, E. R.; Miles, A.; Desewu, K.; Williams, I.; Egyir-Yawson, A.; Sedda, L.; Weetman, D.; Donnelly, M. J.
10.1101/2025.06.13.655782 — genomics — Posted on 2025-06-13
328 White matter micro- and macrostructural properties in midlife individuals at risk for Alzheimer's disease: Associations with sex and menopausal status
Raikes, A. C.; Dyke, J. P.; Nerattini, M.; Boneu, C.; Ajila, T.; Fauci, F.; Battista, M.; Pahlajani, S.; Williams, S.; Brinton, R. D.; Mosconi, L.
10.1101/2025.06.09.658686 — neuroscience — Posted on 2025-06-13
329 Phosphorylation-inducing chimera rewires oncogenic kinase to trigger apoptosis
Merz, M. M.; Shoba, V. M.; Pergu, R.; Severance, Z. C.; Munkanatta Godage, D. N. P.; Deb, A.; Kwok, H. S.; Singh, P.; Singh, S.; Allen, J. B.; Tian, W.; Gosavi, P. M.; Chaudhary, S. K.; Anokhina, V.; Weisberg, E. L.; Payne, N. C.; He, Y.; Osadchey, R.; Shekhar, M.; Mazitschek, R.; Rees, M. G.; Roth, J. A.; Cui, Q.; Griffin, J. D.; Liau, B. B.; Choudhary, A.
10.1101/2025.06.13.659082 — synthetic biology — Posted on 2025-06-13
330 Humanized Caffeine-Inducible Systems for Controlling Cellular Functions
Scheller, L.; Correia, B.; Elia, M.; Kang, C.; Bonati, L.; Gainza, P.; Garodia, Y.; Deshpande, P.; Schmidt, J.; Georgeon, S.; Tang, L.
10.1101/2025.06.13.659463 — synthetic biology — Posted on 2025-06-13
331 Titania Nanoparticle Regulate Innate Immunity
Whittaker, J. J.; Eikrem, D.; Seisenbaeva, G. A.; Fromell, K.; Ekdahl, K. N.; Nilsson, B.; Sandgren, M.; Kessler, V. G.
10.1101/2025.06.13.658543 — biochemistry — Posted on 2025-06-13
336 MORC2 directs transcription-dependent CpG methylation of human LINE-1 transposons in early neurodevelopment
Dorazehi, F.; Francesconi, C.; Pandiloski, N.; Castilla-Vallmanya, L.; Albecka, A.; Koutounidou, S.; Mohan, S. B.; Adami, A.; Katsikas, A.; Matijevic, J.; Karlsson, O.; Davis-Hansson, C.; Johansson, J. G.; Modis, Y.; Jakobsson, J.; Douse, C. H.
10.1101/2025.06.11.658943 — molecular biology — Posted on 2025-06-13
340 Toward Essential Oil Stewardship Strain-Resolved Evaluation of Thyme Oil Activity Against Pseudomonas aeruginosa
Brozyna, M.; Stepnicka, Z.; Tyminska, N.; Dudek, B.; Kapczynska, K.; Matkowski, A.; Sun, Y.; Junka, A.
10.1101/2025.06.13.659493 — microbiology — Posted on 2025-06-13
343 The mPFC molecular clock mediates the effects of sleep deprivation on depression-like behavior and regulates sleep consolidation and homeostasis
Gardner, W.; Sarrazin, D. H.; Balzinger, M.; Marchese, C.; Ragno, A.; Ramanathan, C.; Veleanu, M.; Vestring, S.; Normann, C.; Bourgin, P.; Serchov, T.
10.1101/2025.06.09.658701 — neuroscience — Posted on 2025-06-13
344 Cancer systems immunology reveals myeloid - T cell interactions and B cell activation mediate response to checkpoint inhibition in metastatic breast cancer
Gonzalez, E.; Kreger, J.; Liu, Y.; Wu, X.; Barbetta, A.; Baugh, A.; Al-Zubeidy, B.; Jang, J.; Shin, S. M.; Jacobo, M.; Stearns, V.; Connolly, R. M.; Ho, W.; Emamaullee, J.; MacLean, A. L.; Roussos Torres, E. T.
10.1101/2025.06.09.658361 — cancer biology — Posted on 2025-06-13
346 AbDesign: Database of point mutants of antibodies with associated structures reveals poor generalization of binding predictions from machine learning models.
Janusz, B.; Chomicz, D.; Demharter, S.; Arts, M.; Kanter, J. d.; Wilke, Y.; Britze, H.; Wrobel, S.; Gawlowski, T.; Dudzic, P.; Ukkivi, K.; Peil, L.; Spreafico, R.; Krawczyk, K.
10.1101/2025.06.09.658639 — bioinformatics — Posted on 2025-06-13
348 Thermally controlled state switches for macrophage immunotherapy
Liu, A.; Farooq, A. S.; Abedi, M. H.; Smith, C. A. B.; Wu, D.; Shapiro, M. G.
10.1101/2025.06.09.658763 — bioengineering — Posted on 2025-06-13
349 Metabolism of epigenetic ribonucleosides leads to nucleolar stress and cytotoxicity
Sun, X.; Donlic, A.; Boyer, J. A.; Reddy, N.; Brangwynne, C. P.; Rabinowitz, J. D.; Kleiner, R. E.
10.1101/2025.06.11.659152 — biochemistry — Posted on 2025-06-13
351 Proteomics- and BRET-screens identify SPRY2 as Ras effector that impacts its membrane organisation
Pavic, K.; Hood, F. E.; Duval, C. J.; Manoharan, G. b.; Laurini, C.; Siddiqui, F. A.; Mo, S. P.; Prior, I. A.; Abankwa, D.
10.1101/2025.06.13.659437 — biochemistry — Posted on 2025-06-13
353 SARS-CoV-2 envelope protein induces LC3 lipidation via the V-ATPase-ATG16L1 axis
Figueras-Novoa, C.; Timimi, L. J.; Marcassa, E.; Taveira-Marques, R.; Adams, L.; Jiang, M.; Wu, M. Y.; Montaner, B.; Ng, K.; De Lorenzo, G.; Furnon, W.; Cowton, V. M.; Upfold, N.; Kassiotis, G.; Harvey, R.; Patel, A. H.; Howell, M.; Ulferts, R.; Beale, R.
10.1101/2025.06.12.659257 — cell biology — Posted on 2025-06-13
354 Molecular Mechanisms of DNMT3A-3L-Mediated de novo DNA Methylation on Chromatin
Yan, Y.; Zhou, X. E.; Thomas, S. L.; Liu, M.; Lai, G.-Q.; Worden, E. J.; Jones, P. A.; Xu, T.-H.
10.1101/2025.06.10.658647 — molecular biology — Posted on 2025-06-13
355 Digital PCR detection of Mycobacterium tuberculosis and HIV-1 co-localization in spinal tuberculosis biopsies
Waters, R.; Martineau, A.; Laubscher, M.; Dunn, R. N.; Held, M.; Abrahams, M.-R.; Coussens, A. K.
10.1101/2025.06.11.659223 — molecular biology — Posted on 2025-06-13
357 Scavenger Receptor class F member 2 is an intracellular receptor for Hepatitis B virus
Li, C.; Wang, Y.; Xiong, R.; Li, Q.; Zhou, Z.; Liu, Q.; Qi, Y.; Gao, Z.; Xu, G.; Fang, L.; Sun, Y.; Farzan, M.; Choe, H.; Sui, J.; Li, W.
10.1101/2025.06.13.659407 — microbiology — Posted on 2025-06-13
358 Microbial Worlds Apart: Distinct Communities in Crude Oil and Production Waters
Alibrandi, A.; Plewka, J.; Vuillemin, A.; Bartholomaeus, A.; di Primio, R.; Probst, A. J.; Kallmeyer, J.
10.1101/2025.06.13.658281 — microbiology — Posted on 2025-06-13
360 Experience-dependent sharp-wave ripple deficits in an Alzheimer's disease mouse model
Schnur, P.; Byron, N.; Gerasimou, S.; Pascual Clavel, A.; Rohner, V.; Patriarchi, T.; Sakata, S.
10.1101/2025.06.09.658771 — neuroscience — Posted on 2025-06-13
362 Lipid droplet dysmetabolism affects cell homeostasis in an in vitro model of Alzheimer disease
Fernandes, T.; Caldeira, M.; Melo, T.; Neves, B. B.; Carvalho, C.; Resende, R.; Filadi, R.; Pizzo, P.; Domingues, M. R.; Pereira, C. F.; Moreira, P. I.
10.1101/2025.06.09.658644 — neuroscience — Posted on 2025-06-13
363 Caffeine-regulated molecular switches for functional control of CAR T cells in vivo
Sylvander, E.; Salzer, B.; Emminger, D.; Baik, H.; D'Accardio, G.; Schaefer, M.; Mouratidis, K.; Buri, M. C.; Maresch, D.; Urbanetz, A.; Seigner, J.; Marchiori, E.; Munoz-Lopez, A.; Engert, F.; Engels, B.; Mittelstaet, J.; van der Veeken, J.; Rosato, A.; Zuber, J.; Putz, E. M.; Zajc, C. U.; Lehner, M.; Traxlmayr, M. W.
10.1101/2025.06.13.659487 — synthetic biology — Posted on 2025-06-13
364 Altered kinematics and muscle activities during half squats in people with ankle sprain history
Matsumura, U.; Tsurusaki, T.; Ogusu, R.; Yamamoto, S.; Lee, Y.; Sunagawa, S.; Koseki, H.
10.1101/2025.06.10.658971 — physiology — Posted on 2025-06-13
368 Metagenomic enables the first detection of Trypanosoma sp. in Streblidae (Diptera: Hippoboscoidea) parasitizing bats in Sao Paulo, Brazil.
Marcatti, R. d. A.; Franco, L. A. M.; Rocha, E. C.; Nardi, M. S.; Summa, J. L.; da Silva, E. T. B. C.; da Rosa, A. R.; de Oliveira, D. C.; Graciolli, G.; Sabino, E. C.
10.1101/2025.06.12.659397 — microbiology — Posted on 2025-06-12
369 Fast Evolution of SOS-Independent Multi-Drug Resistance in Bacteria
Zhang, L.; Guan, Y.; Cheng, Y. Y.; Cokcetin, N. N.; Bottomley, A.; Robinson, A.; Harry, E.; van Oijen, A. M.; Su, Q. P.; Jin, D.
10.1101/2022.03.29.486198 — microbiology — Posted on 2025-06-13
370 HAVEN: Hierarchical Attention for Viral protEin-based host iNference
Antony, B.; Haghani, M.; Lauring, A. S.; Karpatne, A.; Murali, T. M.
10.1101/2025.06.09.658367 — bioinformatics — Posted on 2025-06-13
371 Inference of single cell profiles from histology stains with the Single-Cell omics from Histology Analysis Framework (SCHAF)
Comiter, C.; Chen, X.; Vaishnav, E. D.; Kobayashi-Kirschvink, K. J.; Ciapmricotti, M.; Zhang, K.; Murray, J.; Monticolo, F.; Qi, J.; Tanaka, R.; Brodowska, S. E.; Li, B.; Yang, Y.; Rodig, S. J.; Karatza, A.; Quintanal Villalonga, A.; Turner, M.; Pfaff, K. L.; Jane-Valbuena, J.; Slyper, M.; Waldman, J.; Vigneau, S.; Wu, J.; Blosser, T. R.; Segerstolpe, A.; Abravanel, D.; Wagle, N.; Demehri, S.; Zhuang, X.; Rudin, C. M.; Klughammer, J.; Rozenblatt-Rosen, O.; Stultz, C. M.; Shu, J.; Regev, A.
10.1101/2023.03.21.533680 — bioinformatics — Posted on 2025-06-13
372 Generative prediction of real-world prevalent SARS-CoV-2 mutation with in silico virus evolution
Liu, X.; Nie, Z.; Si, H.; Shen, X.; Liu, Y.; Huang, X.; Dong, T.; Xu, F.; Ren, Z.; Zhou, P.; Chen, J.
10.1101/2024.11.28.625962 — evolutionary biology — Posted on 2025-06-13
375 Decoding Cellular Stress States for Toxicology Using Single-Cell Transcriptomics
Shah, I.; Gallegos, D.; Robinette, B.; Chambers, B. A.; Eastburn, D.; Camiolo, S.; White, K.; Martin, N.; Montis, G.; McComb, J.; Seligmann, B.; Chorley, B. N.
10.1101/2025.06.10.657506 — pharmacology and toxicology — Posted on 2025-06-13
376 Composition of Carotid Plaques Differs Between Chinese and United States Patients: A Histology Study
Cao, J.-L.; Ferguson, M.; Sun, J.; shen, M.; Small, R. C.; Hippe, D. S.; Zhao, X.; Zhang, D.; Watase, H.; Yuan, C.; Gao, P.-y.; Demarco, J. K.; Nicosia, R. F.; Wang, Y.-J.; Li, H.-W.; Li, Z.-R.; Wang, Y.; Kohler, T. R.; Hatsukami, T.; Sui, B.
10.1101/2025.06.10.658993 — pathology — Posted on 2025-06-13
377 Spatial multi-omics and deep learning reveal fingerprints of immunotherapy response and resistance in hepatocellular carcinoma
Wu, Z.; Boen, J.; Jindal, S.; Basu, S.; Bieniosek, M.; He, S.; LaPelusa, M. B.; Mayer, A. T.; Kaseb, A. O.; Zou, J.; Sharma, P.; Trevino, A. E.
10.1101/2025.06.11.656869 — cancer biology — Posted on 2025-06-13
378 Rodents as Potential Reservoirs for Toroviruses
Buigues Bisquert, J.; Vinals, A.; Martinez-Recio, R.; Monros, J. S.; Sanjuan, R.; Cuevas, J. M.
10.1101/2025.06.12.659308 — microbiology — Posted on 2025-06-13
386 GVB-positive neurons are resilient to tau-induced impairment of protein synthesis
Smits, J. F. M.; Ligthart, T. W.; Jorge-Oliva, M.; Middelhoff, S.; Schipper, F.; Pita-Illobre, D.; Li, K. W.; Scheper, W.
10.1101/2025.03.28.645932 — neuroscience — Posted on 2025-06-13
388 Lung inflammation is associated with lipid deposition
Potashnikova, D. M.; Tvorogova, A. V.; Komissarov, A. A.; Saidova, A. A.; Sotnikova, T. N.; Makarova, V. O.; Arifulin, E. A.; Lipina, T. V.; Shirokova, O. M.; Melnikov, E. S.; Rodina, T. A.; Valyaeva, A. A.; Zharikova, A. A.; Zayratyants, G. O.; Zayratyants, O. V.; Sheval, E. V.; Margolis, L. B.; Vasilieva, E. Y.
10.1101/2022.12.30.522299 — pathology — Posted on 2025-06-13
393 Chiari II brain malformation is secondary to open spina bifida
Clark, M.; Edwards, T. J.; Savery, D.; Galea, G. L.; Samy, N.; Pauws, E.; Kessaris, N.; Greene, N. D.; Copp, A. J.
10.1101/2025.01.06.631442 — developmental biology — Posted on 2025-06-13
394 The systemic anti-diabetic effect of polyherbal formulation Varanadi Kashayam is mediated through GLP-1 secretion and DPP4 inhibition
Thottappillil, A.; Kouser, S.; Badiger, A. V.; Pinto, P. G.; Ramachandran, S.; Janadri, S.; Mudagal, M. P.; Kukkupuni, S. K.; Mohan S, S.; Chethala N, V.
10.1101/2024.06.29.601306 — cell biology — Posted on 2025-06-13
395 A new nitrogen biochemical process: Oxidization of ammonium into nitrogen gas using nitrate
lv, x.; zhang, s.; gu, p.; han, x.; li, q.; huang, j.; qu, z.; zhao, d.; wang, z.; li, k.; wang, c.
10.1101/2025.06.12.659240 — microbiology — Posted on 2025-06-13
396 Age-dependent gut microbiota dynamics and their association with male fitness traits in Drosophila melanogaster
Sultanova, Z.; Dönertas, H. M.; Hita, A.; Aguilar, P.; Dag, B.; Lucas-Lledo, J. I.; Latorre, A.; Carazo, P.
10.1101/2025.05.22.655607 — microbiology — Posted on 2025-06-13
400 Distinct heterozygous TTC7A missense variants lead to different intestinal epithelial phenotypes in pediatric IBD
Jeshvaghani, Z. S.; Deenichina, P.; Collen, L.; de Vries, M.; Brunsveld, J.; Kotlarz, D.; Koletzko, S.; Klein, C.; Beekman, J.; Snapper, S.; Lindemans, C.; Mokry, M.; Argmann, C.; Kuijk, E.; Nieuwenhuis, E.
10.1101/2025.06.11.659065 — genetics — Posted on 2025-06-13
401 Shouldering the challenge of deciphering avian palate evolution
Benito, J.; Kuo, P.-C.; Torres, C. R.; Navalon, G.; Plateau, O.; Clark, A. D.; Steell, E. M.; Field, D. J.
10.1101/2025.06.10.658509 — evolutionary biology — Posted on 2025-06-13
402 Deciphering the microbial landscape of lower respiratory tract in health and respiratory diseases
Cheng, C.; Li, Y.; Wang, S.; Wang, H.; Liu, D.; Wang, Q.; Che, Y.; Xue, L.; Chao, N.; He, X.; Li, C.; Tian, H.; Zhou, J.; Wang, X.; Yang, Y.; Zhu, Y.; Xu, R.; Wang, Z.; Li, W.
10.1101/2025.06.11.659233 — microbiology — Posted on 2025-06-13
403 The Art of Not Knowing: Accommodating Structured Missingness in Biomedical Research
Rehak Buckova, B.; Fraza, C.; Koldbaek, C.; Barthel Flaaten, C.; Sofie Saether, L.; Cattarinussi, G.; Sando Ambrosen, K. M.; Andreassen, O. A.; Westlye, L. T.; Beckmann, C.; Ebdrup, B.; Dazzan, P.; Ueland, T.; Mitra, R.; Marquand, A.
10.1101/2025.06.07.658014 — neuroscience — Posted on 2025-06-13
404 Multiplex Proteomics of Lewy Body Dementia Reveals Cerebrospinal Fluid Biomarkers of Disease Pathology and Progression
Higginbotham, L.; Shantaraman, A.; Guo, Q.; Fox, E. J.; Bagchi, P.; Wu, F.; Lah, J. J.; Levey, A. I.; Seyfried, N. T.
10.1101/2025.06.10.658994 — systems biology — Posted on 2025-06-13
407 EFFECTS OF ATTACHMENT DESIGNS ON CLEAR ALIGNER TOOTH MOVEMENT: A FINITE ELEMENT ANALYSIS
Mamboleo, E.; Ouldyerou, A.; Alsharif, K.; Ngan, P.; Guan, G.; Merdji, A.; Mukdadi, O.; Egon Mamboleo, Abdelhak Ouldyerou, Khaled Alsharif, Peter Ngan, Guoqiang Guan, Ali Merdji, and Osama,
10.1101/2025.06.11.659198 — bioengineering — Posted on 2025-06-13
414 Predicting protein stability changes upon mutations with dual-view ensemble learning from single sequence
Nie, Z.; Ma, Y.; Liu, Y.; Huang, X.; Liu, Z.; Yang, P.; Xu, F.; Yin, F.; Li, Z.; Fu, J.; Ren, Z.; Zhang, W.-B.; Chen, J.
10.1101/2024.04.22.590665 — bioinformatics — Posted on 2025-06-13
416 Human Peripheral Nerve-on-a-Chip on a Multiwell Microelectrode Array as a Scalable Preclinical Neurotoxicity Assay
Rountree, C.; Rodriguez, T.; Byrne, E.; Schmidt, E.; Schwarzbach, E.; Dillon, S.; McCrimmon, A.; Terral, M.; Metea, M.; Moore, M. J.; Curley, J. L.
10.1101/2025.06.09.658615 — pharmacology and toxicology — Posted on 2025-06-12
418 Contextual modulation and blunted defensive responses to predators in head-fixed and freely moving mice
Ritter, M.; Barreira, L. M. C.; Sach, L.; Hakus, A.; Oektem, S. K.; Bergmann, R.; Voigt, A.; Schmitz, D.; Poirazi, P.; Larkum, M. E.; Sachdev, R.
10.1101/2025.06.09.658679 — animal behavior and cognition — Posted on 2025-06-12
419 A survey of dietary effects on tRNA abundance and modifications
Liu, S.; Holmes, A. D.; Zhao, R.; Herbert, C.; Limbach, P. A.; Lowe, T. M.; Sharma, U.
10.1101/2025.06.10.658430 — genomics — Posted on 2025-06-12
420 Direct RNA nanopore sequencing reveals rapid RNA modification changes following glucose stimulation of human pancreatic beta-cell lines
Mulroney, L.; Taylor, H. J.; Lee, A.; Swift, A. J.; Zdravkov, M.; Bonnycastle, L. L.; Brooks, S. Y.; Lee, B. N.; Fitzgerald, T.; Narisu, N.; Biesecker, L. G.; Erdos, M. R.; Nicassio, F.; Birney, E.; Collins, F. S.; Taylor, D. L.
10.1101/2025.06.12.659352 — genomics — Posted on 2025-06-12
421 Phage-Assisted Evolution of Allosteric Protein Switches
Southern, N. T.; von Bachmann, A.-L.; Hovsepyan, A.; Griebl, M.-L.; Wolf, B.; Lemmen, N.; Kroell, A.-S.; Westermann, S.; Mathony, J.; Niopek, D.
10.1101/2025.06.12.659331 — synthetic biology — Posted on 2025-06-12
423 Accounting for differences between Infinium MethylationEPIC v2 and v1 in DNA methylation-based tools
Zhuang, B. C.; Jude, M. S.; Konwar, C.; Yusupov, N.; Ryan, C. P.; Engelbrecht, H.-R.; Whitehead, J.; Halberstam, A. A.; MacIsaac, J. L.; Dever, K.; Tran, T. K.; Korinek, K.; Zimmer, Z.; Lee, N. R.; McDade, T. W.; Kuzawa, C. W.; Huffman, K. M.; Belsky, D. W.; Binder, E. B.; Czamara, D.; Korthauer, K.; Kobor, M. S.
10.1101/2024.07.02.600461 — genomics — Posted on 2025-06-12
424 Methanobrevibacter smithii associates with colorectal cancer through trophic control of the cancer bacteriome
Mohammadzadeh, R.; Mahnert, A.; Zurabischvili, T.; Wink, L.; Kumpitsch, C.; Habisch, H.; Sprengel, J.; Filek, K.; Mertelj, P.; Pernitsch, D.; Hingerl, K.; Gorkiewicz, G.; Diener, C.; Loy, A.; Kolb, D.; Trautwein, C.; Madl, T.; Moissl-Eichinger, C.
10.1101/2025.06.12.659283 — microbiology — Posted on 2025-06-12
425 Planetary-scale metagenomic search reveals new patterns of CRISPR targeting
Roux, S.; Neri, U.; Bushnell, B.; Fremin, B.; George, N.; Gophna, U.; Hug, L. A.; Camargo, A. P.; Wu, D.; Ivanova, N.; Kyrpides, N. C.; Eloe-Fadrosh, E. A.
10.1101/2025.06.12.659409 — microbiology — Posted on 2025-06-12
426 Prophage regulation of Shewanella fidelis 3313 motility and biofilm formation: implications for gut colonization dynamics in Ciona robusta
Natarajan, O.; Gibboney, S. L.; Young, M. N.; Lim, S. J.; Nguyen, F.; Pluta, N.; Atkinson, C. G. F.; Leigh, B. A.; Liberti, A.; Kees, E. D.; Breitbart, M.; Gralnick, J. A.; Dishaw, L. J.
10.1101/2022.11.23.517592 — microbiology — Posted on 2025-06-12
427 Assessing the Sylvatic Yellow Fever Vectors in Southern Brazil
Cardoso, S. F.; Kikuti, L. A. O.; Yoshikawa, A. A. G.; Pinheiro, I. C.; Guesser, J. V. C.; Neves, M. S. A. S.; Couto-Lima, D.; Gatti, R. R.; Prophiro, J. S.; Pitaluga, A. N.; Rona, L. D. P.
10.1101/2025.06.12.659296 — microbiology — Posted on 2025-06-12
428 Pandemic Vibrio parahaemolyticus wave succession by gene loss
Yang, C.; Qiu, H.; Svensson, S. L.; Ni, C.; Gao, S.; Jia, Z.; Wen, H.; Xie, L.; Xu, W.; Qin, Y.; Lin, S.; Wang, J.; Zhang, Y.; Li, Y.; Jiang, M.; Shi, X.; Hu, Q.; Zhou, Z.; Chao, Y.; Yang, R.; Cui, Y.; Martinez-Urtaza, J.; Wang, H.; Falush, D.
10.1101/2024.06.03.596356 — microbiology — Posted on 2025-06-12
429 A single MHCII neoepitope mRNA vaccine elicits CD4 T- and B- cell responses promoting endogenous CD8 anti-tumor immunity
Capietto, A.-H.; Balanca, C.-C.; Bouziat, R.; Wu, T.; Gober, J.; Carbone, C.; Nissenbaum, A.; Hoshyar, R.; Yadav, M.; Gutierrez, A.; Chestnut, Y.; Javinal, V.; Menon, H.; Darmanis, S.; de Simone, M.; Sun, Y.; Seshasayee, D.; Paluch, M.; Bulutoglu, B.; Jones, T.; Wang, Y.; Liao, L.; Duong, E.; Anand, A.; Antonelli, A.; Oei, Y.; Cheung, J.; Luoh, S.-M.; Ziai, J.; Preston, J.; Hung, J.; Freund, E.; Wichner, S.; Oh, J.; Tahtinen, S.; Sahin, U.; ElSohly, A.; Schartner, J.; Delamarre, L.; Mellman, I.; Linehan, J.
10.1101/2025.06.09.657934 — immunology — Posted on 2025-06-12
431 GABA-independent activation of GABAB receptor by mechanical forces
Hu, Y.; Zhou, Y.; Lin, L.; Yang, F.; He, F.; Zhang, F.; Song, M.; Shen, C.; Liu, Y.; Xu, C.; Xu, S.; Liu, J.
10.1101/2025.06.09.658551 — neuroscience — Posted on 2025-06-12
432 Striatal output regulates the postnatal maturation of cortical circuits
Janecek, M.; Deemyad, T.; Shih, Y.-C.; Valle, V.; D'Agostino, A.; Matarazzo, M.; Perez, M.; Ketchesin, K.; Silva, S.; Peixoto, R.
10.1101/2024.05.10.593512 — neuroscience — Posted on 2025-06-12
437 Lrrc14b is a novel regulator of striated muscle function
Akinborewa, O.; Prabakaran, A. D.; Durumutla, H. B.; Latimer, H.; McFarland, K.; Quattrocelli, M.
10.1101/2025.06.09.658659 — physiology — Posted on 2025-06-12
438 The metabolic and molecular mechanisms underlying running-induced energy compensation
Sanchis, P.; Baech-laursen, C.; Vizueta, J.; Haytural, H.; Kurgan, N.; Persson, K. W.; Groenning, A.; Salinas, R.; Samodova-Sommer, D.; Guo, J.; Jensen, T. E.; Deshmukh, A. S.; Pedersen, B. K.; Brandt, C.
10.1101/2025.06.09.658628 — physiology — Posted on 2025-06-12
445 M. tuberculosis meets European Lead Factory - identification and structural characterization of novel Rv0183 inhibitors using X-ray crystallography
Riegler-Berket, L.; Goedl, L.; Polidori, N.; Aschauer, P.; Grininger, C.; Prosser, G.; Lichtenegger, J.; Sagmeister, T.; Parigger, L.; Gruber, C. C.; Reiling, N.; Oberer, M.
10.1101/2025.06.12.659322 — biochemistry — Posted on 2025-06-12
449 WAVE complex forms linear arrays at negative membrane curvature to instruct lamellipodia formation.
Wu, M.; Sadhu, R. K.; Meyer, K.; Tang, Z.; Marchando, P.; Woolfson, D. N.; Gov, N. S.; Weiner, O. D.
10.1101/2024.07.08.600855 — cell biology — Posted on 2025-06-12
450 Age-Related Patterns of DNA Methylation Changes
Chen, K. Y.; Wang, W.; Suryadevara, H. N. S. K.; Peng, G.
10.1101/2024.12.10.627727 — molecular biology — Posted on 2025-06-12
451 Structural Basis for Cas9-Directed Spacer Acquisition in Type II-A CRISPR-Cas Systems
Li, Z.; Li, Y.; Kong, J.; Wu, Q.; Huang, P.; Zhang, Y.; Wu, W.; Chen, M.; Liu, Y.; Lin, H.; Hou, L.; Liu, G.; Zeng, T.; He, Y.; Hu, C.; Yang, Z.; Lu, M.; Min, L.; Xiao, Y.
10.1101/2025.06.12.659315 — molecular biology — Posted on 2025-06-12
452 Ralstonia pseudosolanacearum LOV domain protein regulates environmental stress tolerance, iron homeostasis, and bacterial wilt virulence
O'Banion, B.; Carter, M. D.; Sanchez-Gallego, J. A.; Li, H.; Hayes, S. S.; Strysick, M.; Holcomb, J.; Allen, C.
10.1101/2025.06.11.659228 — microbiology — Posted on 2025-06-12
454 Chenodeoxycholic Acid Modulation via Bacteroides intestinalis AM1 underscores a Novel Approach in Acute Liver Failure
PANDEY, S.; Sharma, N.; Sharma, N.; Bhat, S. H.; Sharma, V.; Kushwaha, M.; Kumar, A.; Magar, Y.; Gupta, A.; Mathew, B.; Tripathi, G.; Bindal, V.; Yadav, S.; Yadav, M.; Parasar, A.; Sharma, S.; Bihari, C.; Katyal, A.; Maiwall, R.; Sarin, S. K.; Maras, J. S.
10.1101/2025.06.11.659225 — microbiology — Posted on 2025-06-12
455 Bacterial species and surface structures shape gene transfer and the transcriptional landscape during early conjugation
Williams, G. C.; Danne, J. C.; Crawford, S.; Homman-Ludiye, J.; Kostoulias, X.; Islam, T.; Heron, B.; Yong, M.; Gan, Y.-H.; Srikhanta, Y.; Lyras, D.
10.1101/2025.06.12.659224 — microbiology — Posted on 2025-06-12
457 Full inter-hemispheric integration sustained by a fraction of posterior callosal fibers
Santander, T.; Bekir, S.; Paul, T.; Simonson, J. M.; Wiemer, V. M.; Skinner, H. E.; Hopf, J. L.; Rada, A.; Woermann, F. G.; Kalbhenn, T.; Giesbrecht, B.; Bien, C. G.; Sporns, O.; Gazzaniga, M. S.; Volz, L. J.; Miller, M. B.
10.1101/2025.02.14.638327 — neuroscience — Posted on 2025-06-12
458 Hyperpolarization-activated cation channel mediated intrinsic plasticity changes underlie the malleability of with-in cell-type electrophysiological heterogeneity
Chameh, H. M.; Falby, M.; Yang, Y.; Movahed, M.; Arbabi, K.; Sarathy, C.; Tripathy, S. J.; Zhang, L.; Lefebvre, J.; Valiante, T. A.
10.1101/2025.06.09.658517 — neuroscience — Posted on 2025-06-12
459 Human brain cell types shape host-rabies virus transcriptional interactions revealing a preexisting pro-viral astrocyte subpopulation
Feige, L.; Young, K.; Cerapio, J. P.; Kozaki, T.; Kergoat, L.; Libri, V.; Ginhoux, F.; Hasan, M.; Ben Ameur, L.; Chin, G.; Goode, Z.; Bourhy, H.; Saunders, A.
10.1101/2024.12.18.629263 — neuroscience — Posted on 2025-06-12
461 A fast TMT-based proteomic workflow reveals neural enrichment in neurospheres of hiPSC-derived neural stem cells
Muniz, P. d. L.; Souza, L. R. Q.; Martins, M. R.; Valadares, W.; Nogueira, F. C. S.; Rehen, S.; Nugue, G.; Junqueira, M.
10.1101/2025.06.09.658417 — bioinformatics — Posted on 2025-06-12
462 Structural insights into Cas9-mediated prespacer selection in CRISPR-Cas adaptation
Gaizauskaite, U.; Tamulaitiene, G.; Silanskas, A.; Gasiunas, G.; Siksnys, V.; Sasnauskas, G.
10.1101/2025.06.12.659244 — microbiology — Posted on 2025-06-12
463 A new nitrogen biochemical process: Oxidization of ammonium into nitrogen gas using nitrate
lv, x.; zhang, s.; gu, p.; han, x.; li, q.; huang, j.; qu, z.; zhao, d.; wang, z.; li, k.; wang, c.
10.1101/2025.06.12.659240 — microbiology — Posted on 2025-06-12
464 Stereotypy is strongly linked to multiple biomarkers of oxidative stress--a potential common etiology for Abnormal Repetitive Behaviors
Coden, K. M.; Beacham, K.; Stix-Brunell, B.; Moorhead, R.; Byrd, K.; Baker, J.; Geronimo, J.; Parker, K. J.; Garner, J. P.
10.1101/2025.06.09.658735 — animal behavior and cognition — Posted on 2025-06-12
466 Species-specific oculomotor control tolerances predict saccadic suppression strength in macaques and zebrafish
Soto, G.; Dehmelt, F. A.; Baumann, M. P.; Tunc, I.; Yu, Y.; Malevich, T.; Hafed, Z. M.; Arrenberg, A. B.
10.1101/2025.06.09.658731 — neuroscience — Posted on 2025-06-12
467 Organellar data sets confirm overall angiosperm relationships if problematic RNA-edit sites are accounted for in mitochondrial genomes
Gerelle, W. K.; Jost, M.; Marques, I.; Les, D.; Vallejos, R.; Little, S.; Sinn, B. T.; Sokoloff, D. D.; Macfarlane, T. D.; Iles, W.; Feild, T.; Mathews, S.; Moore, M.; Couvreur, T. L. P.; Sauquet, H.; Wanke, S.; Graham, S. W.
10.1101/2025.06.09.658674 — plant biology — Posted on 2025-06-12
468 Anti-isoDGR Antibody Inhibits Atherosclerosis Induced by Western Diet in ApoE-/- mice
Kalailingam, P.; Ngan, S. C.; Gallart-Palau, X.; Serra, A.; Datta, A.; Ch'ng, T. H.; Tsiani, E. L.; Klentrou, P.; Kalaria, R. N.; McCarthy, N. E.; De Kleijn, D.; Sze, S. K.
10.1101/2025.06.09.658749 — pharmacology and toxicology — Posted on 2025-06-12
470 Autocrine TGFβ2 enforces a transcriptionally hybrid cell state in Ewing sarcoma
Wrenn, E. D.; Harris, J. C.; Apfelbaum, A.; Valenti, J. R.; Lipson, P. A.; Walter, S. I.; Garcia, N. M.; Miyaki, A.; Chen, S. C.; Olson, J. M.; Price, J. S.; Bailey, K. M.; Lawlor, E. R.
10.1101/2025.06.11.653876 — cancer biology — Posted on 2025-06-12
480 A Thiopurine-like Mutagenic Process Defines TGCT Subtypes
Brown, K. M.; Zhong, J.; Miranda, A. M.; Zhang, M.; Williams, J.; Williams, J.; Zhang, H.; Liang, C.; Li, W.; Zhu, B.; Chanock, S. J.; Nathanson, K. L.; Zhang, T.
10.1101/2025.06.12.655573 — genomics — Posted on 2025-06-12
481 Unbiased recording of clonal potency reveals species-specific regulation of mammalian intestine
Islam, M.; Bechard, M. E.; Yang, Y.; Simmons, A. J.; Xu, Y.; Higginbotham, J. N.; Zhao, P.; Cao, Z.; Tasneem, N.; Glass, S. E.; Markham, N. O.; Revetta, F.; Ramirez-Solano, M. A.; Liu, Q.; Franklin, J. L.; Lau, K.; Coffey, R. J.
10.1101/2025.06.10.658707 — genomics — Posted on 2025-06-12
483 Juvenile hormone degradation enzymes have shared and unique requirements in Drosophila development
Siegel, H.; Healy, C.; Goyins, K.; Jumamyradova, A.; Ying, J.; Soshnev, A. A.; Spokony, R. F.; Barton, L. J.
10.1101/2025.06.09.657647 — genetics — Posted on 2025-06-12
486 Population genomics of incipient allochronic divergence in the Pine Processionary Moth
Muller, T.; Gautier, M.; Lombaert, E.; Leblois, R.; Saune, L.; Branco, M.; Kerdelhue, C.; Perrier, C.
10.1101/2025.06.09.657100 — evolutionary biology — Posted on 2025-06-12
488 Spatial Biodiversity Indicators and a Composite Index for Conservation Prioritization in Switzerland
Adde, A.; Boussange, V.; Chauvier, Y.; Dahito, M.-A.; Fruh, J.; Gross, A.; Stofer, S.; Rey, E.; Sieber, P.; Fopp, F.; Schouten, R.; Van Moorter, B.; Guisan, A.; Graham, C.; Pellissier, L.; Zimmermann, N. E.; Altermatt, F.
10.1101/2025.06.10.657334 — ecology — Posted on 2025-06-12
491 A single-cell fixed RNA profiling of liver fibrosis progression and regression reveals SEMA4D and LMCD1 as key mediators of fibrogenesis
Pham, D. M.; Thuy, L. T. T.; Hoang, H.; Nguyen, H. T.; Pham, A. T.; Ikenaga, H.; Fuji, H.; Yuasa, H.; Matsubara, T.; Vu, H. T.; Yi, C.; Yamagishi, R.; Ohtani, N.; Oikawa, D.; Tokunaga, F.; Kisseleva, T.; Brenner, D.; Iwakiri, Y.; Sancho, J. G.; Kawada, N.
10.1101/2025.06.12.657772 — cell biology — Posted on 2025-06-12
494 Shaping a Collaborative, Sustainable, Accessible, and Reproducible Future for Computational Modeling
Guidon, M.; Kaiser, D.; Iavarone, E.; Anderegg, S.; Bisgaard, M.; Bujard, C.; Cassara, A.; Crespo-Valero, P.; Drobuliak, M.; Fasse, A.; Hrytsuk, Y.; Karimi, F.; Maiz, O.; Neagu, A.; Newton, T.; Ordonez, J.; Oetiker, T.; Pascual, I.; Querido, J.; Regel, S.; Steiner, M.; Van Geit, W.; Zhuang, K.; Weitz, A.; Chavannes, N.; Kuster, N.; Neufeld, E.
10.1101/2025.06.12.656959 — neuroscience — Posted on 2025-06-12
496 Oncogenic and tumor-suppressive forces converge on a progenitor-orchestrated niche to shape early tumorigenesis
Reyes, J.; Del Priore, I.; Chaikovsky, A. C.; Pasnuri, N.; Elhossiny, A. M.; Krause, T.; Moorman, A.; Snopkowski, C.; Takizawa, M.; Burdziak, C.; Ratnayeke, N.; Masillioni, I.; Ho, Y.-J.; Chaligne, R.; Romesser, P. B.; Filliol, A.; Nawy, T.; Morris, J. P.; Zhao, Z.; Di Magliano, M. P.; Alonso-Curbelo, D.; Pe'er, D.; Lowe, S. W.
10.1101/2025.06.10.656791 — cancer biology — Posted on 2025-06-12
498 Advancing Fair and Explainable Machine Learning for Neuroimaging Dementia Pattern Classification in Multi-Ethnic Populations
Ho, N.-H.; Charisis, S.; Honnorat, N.; Brandigampala, S. R.; Wang, D.; Heckbert, S. R.; Fox, P. T.; Martinez, D.; Wang, D. H.; Hughes, T. M.; Archer, D. B.; Hohman, T. J.; Seshadri, S.; Davatzikos, C.; Habes, M.
10.1101/2025.06.09.658375 — neuroscience — Posted on 2025-06-12
499 DR5 CAR-T cells target solid tumors and suppress MDSCs with minimal toxicity
Wang, H.; Liu, S.; Sinha, P.; Liu, F.; Zhang, X.; Guo, Y.; Goncalves, B.; Zheng, Q.; Mou, H.; Yang, J.; Huang, L.; Scholler, J.; Miao, F.; Zeng, T.; Karakousis, G.; Huang, A. C.; Mitchell, T.; Amaravadi, R.; Schuchter, L.; Milone, M.; Guo, W.; June, C. H.; Herlyn, M.; Fan, Y.; Xu, X.
10.1101/2025.06.09.658618 — cancer biology — Posted on 2025-06-12
503 Single-nucleus analysis reveals oxidative stress in Down syndrome basal forebrain neurons at birth
West, N. R.; Arachchilage, K. H.; Knaack, S.; MacGregor, S.; Hosseini, M.; Risgaard, R. D.; Kumarage, P.; Martinez, J. L.; Zhang, S.-C.; Wang, D.; Sousa, A. M. M.; Bhattacharyya, A.
10.1101/2025.02.05.636750 — neuroscience — Posted on 2025-06-12
504 Alterations of the composition and spatial organization of the microenvironment following non-dysplastic Barrett's esophagus through progression to cancer
Lin, M.-L.; Hickey, J. W.; Passman, A.; Carlotti, E.; Devkumar, S.; Derwa, Y. H.; ChinAleong, J.; Hackett, R. J.; Evans, J. A.; Sangwan, V.; Novelli, M. R.; Rodriguez-Justo, M.; Wright, N. A.; Jansen, M.; Underwood, T. J.; Huang, S.; Gascard, P.; McLean, M. H.; Schurch, C. M.; Tlsty, T. M.; Ferri, L.; Nolan, G. P.; McDonald, S. A.
10.1101/2025.06.09.657642 — cancer biology — Posted on 2025-06-12
509 A critical role of sux cistron-mediated sucrose uptake for virulence of the rice blight pathogen Xanthomonas oryzae pv. oryzae
Zoellner, N.; Long, J. Y.; Song, C.; Sharkey, J.; Wudick, M. M.; Loo, E. P.; Sadoine, M.; Applegate, V.; Port, A.; Smits, S.; Yang, B.; Frommer, W. B.
10.1101/2025.06.02.657373 — microbiology — Posted on 2025-06-12
510 Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds.
Meunier, D.; Corona-Torres, R.; Boulton, K.; Wu, Z.; Ballantyne, M.; Glendinning, L.; Ahmad, A. A.; Borowska, D.; Taylor, L.; Vervelde, L.; del Pozo, J.; Vasilogianni, M.; Jaramillo-Ortiz, J.; Sanchez-Arsuaga, G.; Psifidi, A.; Tomley, F.; Watson, K. A.; McGrew, M. J.; Stevens, M. P.; Blake, D. P.; Hume, D. A.
10.1101/2025.01.10.632125 — immunology — Posted on 2025-06-12
512 Male and female mice may respectively form stronger social aversive memories with same and different sex conspecifics
Beaver, J. N.; Nicodemus, M. M.; Spalding, I. R.; Scrimshaw, L. R.; Dutta, S.; Jasnow, A. M.; Gilman, L. M.
10.1101/2024.08.12.607663 — neuroscience — Posted on 2025-06-12
514 ASXL1 truncating mutations drive leukemic resistance to T cell attack
McCurry, D. B.; Ge, Z.; Lee, J.; Pasumarthi, R.; Leng, X.; Koehnke, T.; Pasvolsky, O.; Raparla, P.; Nguyen, V.; Maurer, K.; Li, S.; Livak, K. J.; Danson, E.; Thakkar, B.; Azizi, E.; Soiffer, R. J.; Shukla, S. A.; Majeti, R.; Ritz, J.; Wu, C. J.; Molldrem, J. J.; Bachireddy, P.
10.1101/2025.05.29.656798 — cancer biology — Posted on 2025-06-12
515 Targeting SCD in SCD-amplified prostate cancer inhibits growth in bone by modulating cellular stress, mTOR, and DNA damage pathways
Wilson, A.; Herroon, M. K.; Mecca, S.; Garmo, L.; Lindquist, J.; Rajendran, S.; Patrick, S. M.; PODGORSKI, I.
10.1101/2025.06.09.658523 — cancer biology — Posted on 2025-06-12
518 The complete mitochondrial genome of Tunga penetrans and insights into flea phylogeny
Bartilol, B.; Mburu, M. W.; Owaret, J.; Andisi, C.; Oyier, I.; Muriu, S.; Elson, L.; Maia, M.; Mwangangi, J.; Githinji, G.; Rono, M.
10.1101/2025.06.09.658575 — genomics — Posted on 2025-06-12
520 Measuring renal cortical cell-specific mitochondrial metabolism
Feola, K.; Venable, A. H.; Rasouli, M.; Do, J.; McCoy, T.; Llamas, C. B.; Straus, D.; Mishra, P.; Najafian, B.; Huen, S.
10.1101/2024.11.24.622516 — molecular biology — Posted on 2025-06-12
521 Single-cell transcriptomics yield insights into the stress-immune interplay and inform disease risk
Benavides, S.; Kosyk, O.; Carpenter, L.; Georgiou, C.; Miller, B. C.; Stanley, N.; Zannas, A. S.
10.1101/2025.06.05.658150 — immunology — Posted on 2025-06-12
522 DEVELOPMENT OF A POTENT MONOCLONAL ANTIBODY FOR TREATMENT OF HUMAN METAPNEUMOVIRUS INFECTIONS
Harris, E. D.; McGovern, M.; Pernikoff, S.; Ikeda, R.; Kipnis, L.; Hannon, W.; Sobolik, E. B.; Gray, M.; Greninger, A. L.; He, S.; Chin, C.-N.; Fu, T.-M.; Pancera, M.; Boonyaratanakornkit, J.
10.1101/2025.06.09.657676 — immunology — Posted on 2025-06-12
524 Reduced susceptibility to experimentally-induced complex visual hallucinations with age
Shenyan, O.; Haye, L.; Milne, G. A.; Lisi, M.; Greenwood, J. A.; Skipper, J. I.; Dekker, T. M.
10.1101/2025.05.27.656359 — neuroscience — Posted on 2025-06-12
525 FERONIA defines intact tissue boundaries through cuticle development
Kim, G.; Choi, J.; Kim, R. J.; Oh, E.; Shin, S. Y.; Kim, H.-S.; Cho, H. S.; Suh, M. C.; Lee, H.-J.
10.1101/2025.06.09.658546 — plant biology — Posted on 2025-06-12
526 Alterations of the composition and spatial organization of the microenvironment following non-dysplastic Barrett's esophagus through progression to cancer
Lin, M.-L.; Hickey, J. W.; Passman, A.; Carlotti, E.; Devkumar, S.; Derwa, Y. H.; ChinAleong, J.; Hackett, R. J.; Evans, J. A.; Sangwan, V.; Novelli, M. R.; Rodriguez-Justo, M.; Wright, N. A.; Jansen, M.; Underwood, T. J.; Huang, S.; Gascard, P.; McLean, M. H.; Schurch, C. M.; Tlsty, T. M.; Ferri, L.; Nolan, G. P.; McDonald, S. A.
10.1101/2025.06.09.657642 — cancer biology — Posted on 2025-06-12
527 SAMP-Score: A morphology-based machine learning classification method for screening pro-senescence compounds in p16 positive cancer cells
Wallis, R.; Hughes, B. K.; Moore, M.; O'Sullivan, E. A.; McIlvenna, L. C.; Gammon, L.; Hope, A.; Bellany, F.; Mackenzie, C.; Green, C.; Gray, D.; Bishop, C. L.
10.1101/2025.06.09.658585 — cancer biology — Posted on 2025-06-12
531 COX6B1 secures a redox-sensitive step in early cytochrome c oxidase assembly
Cunatova, K.; Vrbacky, M.; Knezu, M.; Pecinova, A.; Alan, L.; Houstek, J.; Fernandez-Vizarra, E.; Mracek, T.; Pecina, P.
10.1101/2025.03.25.645161 — biochemistry — Posted on 2025-06-12
532 A novel reusable transcriptome-wide association study workflow used to map key genes linked to important cattle traits
Jayaraman, S.; Chitneedi, P. K.; Kadri, N. K.; Costa-Monteiro-Moreira, G.; Salavati, M.; Charlier, C.; Boichard, D.; Sanchez, M.-P.; Pausch, H.; Kuehn, C.; Prendergast, J. G.; Clark, E. L.
10.1101/2025.06.10.658680 — genomics — Posted on 2025-06-12
533 Evaluating Large Language Models for Gene-to-Phenotype Mapping: The Critical Role of Full-Text Database Access
Suhardi, N. M.; Oktarina, A.; Dhillon, D.; Ninan, D.; Retzky, J.; Bostrom, M.; Yang, X.; Suhardi, V. J.
10.1101/2025.06.11.659165 — genetics — Posted on 2025-06-12
534 Biological causes and impacts of rugged tree landscapes in phylodynamic inference
Gao, J.; Brusselmans, M.; Carvalho, L. M.; Suchard, M. A.; Baele, G.; Matsen, F. A.
10.1101/2025.06.10.657742 — evolutionary biology — Posted on 2025-06-12
535 The Green Band: Using Production and Catch to Judge Distortive Pressure on an Ecosystem
Fulton, E. A.; Sainsbury, K.; Bulman, C.; Novaglio, C.; Porobic, J.; Hayes, D.; van Putten, E. I.; Dutra, L. X. C.; Thomas, L.; Norris, W.; Pert, C.; Willock, A.; Montenegro, S. C.; Garay-Narvaez, L.; Hernandez, S.; Hernandez Saso, A.; Mohamed, K. S.; Sathianandan, T. V.; Kuriakose, S.; Varghese, E.; Najmudeen, T. M.; Vasudevan, S.; Anish, M. K. G.; Salim, S.; Mandro, I.; Zador, S.; Ortiz, I.; Whitehouse, A.; Aydin, K.; Tweit, B.; Evans, D.
10.1101/2025.06.09.658403 — ecology — Posted on 2025-06-12
536 An optimized rabies vaccine vehicle for orotopical administration to wild vampire bats.
Knuese, C.; Cardenas-Canales, E. M.; McDevitt-Galles, T.; Ramirez-Martinez, M. M.; Limonta, D.; Powers, L. E.; Walsh, D. P.; Streicker, D. G.; Osorio, J. E.; Zamanian, M.; Rocke, T. E.
10.1101/2025.06.03.657068 — ecology — Posted on 2025-06-12
537 Near-infrared spectroscopy-based models correctly classify Abies alba seed origin and predict germination properties
Poughon, J.; Lepoittevin, C.; Vicente, E.; Carme, M.; Mihai, G.; Lario Leza, F.; Piotti, A.; Avanzi, C.; Marchi, M.; Vendramin, G. G.; Scotti-Saintagne, C.; Fady, B.; Teyssier, C.; Benito Garzon, M.
10.1101/2025.06.09.658572 — ecology — Posted on 2025-06-12
539 Dynamics of cortico-subthalamic neuronal patterns during dyskinesia in Parkinsons disease
Habets, J. G.; Merk, T.; Mathiopoulou, V.; Lofredi, R.; Binns, T. S.; Busch, J. L.; Koehler, R. M.; Memarpouri, A.; Faust, K.; Krause, P.; Schneider, G.-H.; Neumann, W.-J.; Tovote, P.; Kuehn, A. A.
10.1101/2025.06.09.658641 — neuroscience — Posted on 2025-06-12
540 Ablation of hepatocyte derived-FGL1 does not aggravate metabolic dysfunction-associated steatotic liver disease and hepatocellular carcinoma
Personnaz, J.; Cannizzo, L.; Martin, C. M. P.; Desquesnes, A.; Sotin, M.; DaSilva, J.; Perrier, P.; Guillou, H.; Kautz, L.
10.1101/2024.12.23.628701 — pathology — Posted on 2025-06-12
541 Early postnatal resting-state structural-functional coupling in the perisylvian region
Namiranian, R.; Abrishami Moghaddam, H.; Khadem, A.; Jafari, R.; Chalechale, A.
10.1101/2023.10.26.564007 — bioengineering — Posted on 2025-06-12
542 Personalized models of Disorders of Consciousness revealcomplementary roles of connectivity and local parameters in diagnosis and prognosis
Zonca, L.; Escrichs, A.; Patow, G. A.; Manasova, D.; Sanz Perl, Y.; Annen, J.; Gosseries, O.; Laureys, S.; Sitt, J.; Deco, G.
10.1101/2024.09.03.610819 — neuroscience — Posted on 2025-06-12
545 Heightened subcortical reactivity to uncertain-threat is associated with future internalizing symptoms, conditional on stress exposure
Grogans, S. E.; DeYoung, K. A.; Hur, J.; Anderson, A. S.; Islam, S.; Kim, H. C.; Wedlock, J.; Craig, L. E.; Tillman, R. M.; Das, S.; Kuhn, M.; Conway, C. C.; Fox, A. F.; Smith, J. F.; Shackman, A. J.
10.1101/2025.06.11.659182 — neuroscience — Posted on 2025-06-12
546 Therapeutic splice modulation of COL4A5 reinstates collagen IV assembly in an organoid model of X-linked Alport syndrome
Saei, H.; Estebe, B.; Goudin, N.; Esmailpour, M.; Haure, J.; Gribouval, O.; Arrondel, C.; Moriniere, V.; Tian, P.; Lennon, R.; Antignac, C.; Mollet, G.; Dorval, G.
10.1101/2025.06.10.658776 — genetics — Posted on 2025-06-12
547 Integration of Audiovisual Motion in Dorsolateral Prefrontal Cortical Neurons
Karimi, A.; Mozumder, R.; Schoenhaut, A.; Rausis, O.; Wallace, M.; Ramachandran, R.; Constantinidis, C.
10.1101/2025.06.11.656227 — neuroscience — Posted on 2025-06-12
549 Valuing conservation and natural wealth: The blue economy of manta ray watching in the Maldives
Moloney, H. M.; Rojas, M. I. G.; Rothe, N.; Armstrong, A. O.; Ballard, K.; Barraud, F.; Hamdan, F.; Richardson, A. J.; Mohamed Riyad, E.; Sawers, T. J.; Townsend, K. A.; Stevens, G. M. W.
10.1101/2025.06.05.658185 — ecology — Posted on 2025-06-12
551 The unique molecular recognition features of Siglec-10: structural insights into sialoglycan and antibody interactions
Sobczak, K.; Antonana-Vildosola, A.; Valverde, P.; Travecedo, M. A.; Jame-Chernaboo, Z.; Schmidt, E. N.; DAndrea, S.; Valdaliso-Diez, E.; Oyenarte, I.; Laugieri, M. E.; Joe, M.; Mozaneh, F.; Lin, S.-Y.; Bosch, A.; Moure, M. J.; Franconetti, A.; Lee, S. Y.; Etxaniz-Diaz de Durana, J.; Perez-Gutierrez, L.; Palazon, A.; Marcelo, F.; Fadda, E.; Corzana, F.; Gimeno, A.; Macauley, M. S.; Jimenez-Barbero, J.; Ereno-Orbea, J.
10.1101/2025.06.10.658867 — molecular biology — Posted on 2025-06-12
552 A SHERLOCK toolbox for eco-epidemiological surveillance of African trypanosomes in domestic pigs from Western Africa.
Eloiflin, R.-J.; Perez-Anton, E.; Camara, A.; Dujeancourt-Henry, A.; Boiro, S.; N Djetchi, M.; Traore, M.; Koffi, M.; Kaba, D.; Le Pennec, Y.; Doukoure, B.; Camara, A. D.; Kagbadouno, M.; Campagne, P.; Camara, M.; Jamonneau, V.; Thevenon, S.; Bart, J.-M.; Glover, L.; Rotureau, B.
10.1101/2025.03.14.643090 — microbiology — Posted on 2025-06-12
553 MitoTracker transfers from astrocytes to neurons independently of mitochondria
Hole, K. L.; Norkett, R.; Russell, E.; Strom, M.; Howden, J. H.; Corbett, N. J.; Brownlees, J.; Devine, M. J.
10.1101/2025.05.27.655523 — neuroscience — Posted on 2025-06-12
554 Shared and Distinct Lipid Profiles in amygdala from Sporadic and GBA-associated Parkinson's Diseases
Munoz, S. S.; Marlet, F. R.; Dreier, J. E.; Bilgin, M.; Schott, K.; Neergaard, K. B. S.; Bezard, E.; DEHAY, B.; Jaunmuktane, Z.; Maeda, K.; Galvagnion, C.
10.1101/2024.10.11.617800 — neuroscience — Posted on 2025-06-12
556 Local and distributed information coding in the ventral stream
Bogdan, P. C.; Howard, C.; Gillette, K.; Cabeza, R.; Davis, S. W.
10.1101/2025.03.09.642235 — neuroscience — Posted on 2025-06-12
561 ATF4 activates a transcriptional program that chronically suppresses mTOR activity promoting neurodegeneration in Parkinson's disease models
Demmings, M. D.; Kane, E.; Tennyson, E.; Hurley, K.; Zhao, J.; Cruickshanks, N.; Ciz, V.; Krupa, J.; Pasternak, S.; Cregan, S.
10.1101/2025.06.09.658667 — neuroscience — Posted on 2025-06-12
562 Pervanadate-induced oxidation relieves autoinhibition of SRC protein tyrosine kinase
Mulholland, K. E.; Bourguet, M.; Cheng, N.; Rahman, O.; Ezerina, D.; Daly, L. A.; Lai, T.; Casanova, S. A.; Creixell, P.; Eyers, C.; Eyers, P.; Messens, J.; Byrne, D.; Sharpe, H.
10.1101/2025.04.27.650842 — molecular biology — Posted on 2025-06-12
564 PDCD1 expression increases at elevated temperatures.
Toma-Jonik, A.; Janus, P.; Mrowiec, K.; Vydra, N.; Sarkowicz, K.; Bar, M.; Mirek, J.; Olbryt, M.; Fidyk, W.; Widlak, W.
10.1101/2025.05.22.652424 — immunology — Posted on 2025-06-12
567 Why is there so much variability in crop multi-model studies?
Wallach, D.; Palosuo, T.; Mielenz, H.; Buis, S.; Thorburn, P.; Asseng, S.; Dumont, B.; Ferrise, R.; Gayler, S.; Ghahramani, A.; Harrison, M. T.; Hochman, Z.; Hoogenboom, G.; Huang, M.; Jing, Q.; Justes, E.; Kersebaum, K. C.; Launay, M.; Lewan, E.; Liu, K.; Luo, Q.; Mequanint, F.; Nendel, C.; Padovan, G.; Olesen, J. E.; Pullens, J. W. M.; Qian, B.; Seserman, D.-M.; Shelia, V.; Souissi, A.; Specka, X.; Wang, J.; Weber, T. K. D.; Weihermuller, L.; Seidel, S.
10.1101/2023.02.03.526931 — plant biology — Posted on 2025-06-12
569 In Vitro Characterization of Extracellular Vesicles from the Medicinal Plant Centella asiatica for Aesthetic Applications
Chang, T.-M.; Wu, C.-C.; Huang, H.-C.; Wang, S.-S.; Chuang, C.-H.; Kao, P.-L.; Tang, W.-H.; Liu, L. T.-C.; Qiu, W.-Y.; Percec, I.; Chen, C.; Kuo, T.-Y.
10.1101/2024.12.03.624435 — pharmacology and toxicology — Posted on 2025-06-12
574 Social Context Restructures Behavioral Syntax in Mice
Ritter, M.; Shipley, H.; Deiana, S.; Hengerer, B.; Wotjak, C. T.; Brecht, M.; Bogadhi, A. R.
10.1101/2025.04.17.648924 — animal behavior and cognition — Posted on 2025-06-12
575 The gene regulatory landscape driving mouse gonadal supporting cell differentiation
Stevant, I.; Abberbock, E.; Ridnik, M.; Weiss, R.; Swisa, L.; Futtner, C.; Maatouk, D.; Lovell-Badge, R.; Malysheva, V.; Gonen, N.
10.1101/2024.12.09.627451 — developmental biology — Posted on 2025-06-12
578 Afadin-deficient retinas exhibit severe neuronal lamination defects but preserve visual functions
Ueno, A.; Sakuta, K.; Ono, H.; Hashio, A.; Tokumoto, H.; Watanabe, M.; Nishimoto, T.; Konishi, T.; Emori, Y.; Mizuno, S.; Hiratsuka, M.; Miyoshi, J.; Takai, Y.; Tachibana, M.; Koike, C.
10.1101/2024.12.24.630271 — neuroscience — Posted on 2025-06-12
579 The mechanism of ribosomal recruitment during translation initiation on Type 2 IRESs
Bhattacharjee, S.; Abaeva, I.; Brown, Z.; Arhab, Y.; Fallah, H.; Hellen, C. U. T.; Frank, J.; Pestova, T.
10.1101/2025.06.11.659010 — molecular biology — Posted on 2025-06-11
580 MITF maintains genome stability in non-melanocytic cell lineages and suppresses Hippo pathway signaling
Gudmundsdottir, D. H.; de Lomana, A. L. G.; Venkatesh, T. B.; Kirty, K.; Sigurdsson, S.; Vidarsdottir, L.; Dilshat, R.; Sveinbjornsdottir, E.; Ragnarsdottir, S.; Magnusson, D. H.; Bustos, M. R.; Steingrimsson, E.; Gudjonsson, T.; Sigurdsson, S.
10.1101/2025.06.09.658599 — molecular biology — Posted on 2025-06-11
584 Multiple-level organizational logic of the locus coeruleus-norepinephrine system in structure and function
Zhang, C.-M.; Yang, Y.-X.; Li, F.-N.; Zhang, H.; Sun, L.; Li, J.; Yang, C.; Yue, Z.-F.; Feng, J.-S.; Li, Y.-L.; Zhang, R.-W.; He, J.; Du, X.-F.; Du, J.-L.
10.1101/2025.06.11.659024 — neuroscience — Posted on 2025-06-11
585 Cognition-centric brain activity across diverse imaging tasks constrains the representation of mental health in task-evoked brain function
Korponay, C.; Cohen-Gilbert, J. E.; Kumar, P.; Harnett, N. G.; Medina, A. A.; Cheng, Y.; Forester, B. P.; Ressler, K. J.; Demsar, J.; Frederick, B. B.; Beckmann, C. F.; Harper, D. G.; Nickerson, L. D.
10.1101/2025.06.11.659091 — neuroscience — Posted on 2025-06-11
590 Cross-species comparative connectomics reveals the evolution of an olfactory circuit
Roberts, R.; Giez, C.; Dhawan, S.; Pang, S.; Randel, N.; Zhiyuan, L.; Gong, H.; Dekens, L.; DiFrisco, J.; Xu, C. S.; Hess, H.; Zlatic, M.; Cardona, A.; Prieto-Godino, L. L.
10.1101/2025.06.11.659158 — neuroscience — Posted on 2025-06-11
591 Toward Granular Brain Intrinsic Connectivity Networks and Insights into Schizophrenia
Mirzaeian, S.; Jensen, K. M.; Ballem, R.; Andres Camazon, P.; Chen, J.; Calhoun, V.; Iraji, A.
10.1101/2025.06.11.659084 — neuroscience — Posted on 2025-06-11
592 FEDRANN: effective overlap graph construction based on dimensionality reduction and approximate nearest neighbors
Zhang, J.-Y.; Miao, C.; Qiu, T.; Xia, X.; He, L.; He, J.; Sun, Y.; Zeng, T.; Li, Y.; Xu, X.; Ruan, Y.; Dong, Y.
10.1101/2025.05.30.656979 — bioinformatics — Posted on 2025-06-11
593 Structural basis of RNA-guided transcription by a dCas12f-σE-RNAP complex
Xiao, R.; Hoffmann, F. T.; Xie, D.; Wiegand, T.; Palmieri, A. I.; Sternberg, S. H.; Chang, L.
10.1101/2025.06.10.658880 — biochemistry — Posted on 2025-06-11
596 Telomeric Repeat-Containing RNA Increases in Aged Human Cells
Chu, H.-P. C.; Hsieh, Y.-H.; Tai, C.-H.; Yeh, M.-T.; Yang, P.-C.; Chen, Y.-C.; Yen, C.-P.; Han, D.-S.; Shen, H.-J.; Yeh, C.-H.
10.1101/2024.11.14.623513 — genomics — Posted on 2025-06-11
597 Toward a genetic signature of resistance to activity-based anorexia in striatal projecting cortical neurons
Huang, K.; Magateshvaren Saras, M. A.; Conn, K.; Greaves, E.; Reed, F.; Tyagi, S.; Munguba, H.; Foldi, C. J.
10.1101/2025.03.09.642272 — neuroscience — Posted on 2025-06-11
602 Biochemical engineering of 5hmdC-DNA using a Tet3 double-mutant
Sahin, H.; Islam, S.; Lee, A. H.; Ponzo, I.; Reichl, A.; Carell, T.; Giehr, P.
10.1101/2025.06.11.658802 — biochemistry — Posted on 2025-06-11
608 Structures reveal how the Cas1-2/3 integrase captures, delivers, and integrates foreign DNA into CRISPR loci
Henriques, W. S.; Bowman, J.; Hall, L. N.; Gauvin, C. C.; Wei, H.; Kuang, H.; Zimanyi, C. M.; Eng, E. T.; Santiago-Frangos, A.; Wiedenheft, B.
10.1101/2025.06.10.658980 — molecular biology — Posted on 2025-06-11
610 Recovering historical fish eDNA from museum-preserved Antarctic filter feeders via non-destructive metabarcoding.
Jeunen, G.-J.; Mills, S.; Bailie, M.; Mauvisseau, Q.; Lamare, M.; Mariani, S.; Pearman, W.; Zavodna, M.; Treece, J.; Ferreira, S.; Gemmell, N.
10.1101/2025.06.07.656140 — ecology — Posted on 2025-06-11
611 Multimodal Evidence for Hippocampal Engagement and Modulation by Functional Connectivity-Guided Parietal TMS
Li, Z.; Trapp, N. T.; Bruss, J.; Liu, X.; Wu, K.; Chen, Z.; Etkin, A.; Howard, M. A.; Boes, A. D.; Jiang, J.
10.1101/2025.06.08.658503 — neuroscience — Posted on 2025-06-11
612 A Numerical Alternative to MR Thermometry for Safety Validation of Multi-Channel RF Transmit Coils
Sadeghi-Tarakameh, A.; Schmidt, S.; Waks, M.; Lagore, R. L.; Grant, A.; Auerbach, E.; DelaBarre, L.; Knudsen, L.; Lenglet, C.; Vizioli, L.; Yacoub, E.; Adriany, G.; Metzger, G. J.; Ugurbil, K.; Eryaman, Y.
10.1101/2025.06.07.657475 — neuroscience — Posted on 2025-06-11
618 Human fibrosarcoma cells selected for very-high doxorubicin resistance, acquire trabectedin and eribulin cross-resistance, remain sensitive to recombinant methioninase, and have increased c-MYC expression
Morinaga, S.; Han, Q.; Mizuta, K.; Kang, B. M.; Bouvet, M.; Yamamoto, N.; Hayashi, K.; Kimura, H.; Miwa, S.; Igarashi, K.; Higuchi, T.; Tsuchiya, H.; Demura, S.; Hoffman, R. M.
10.1101/2025.06.07.658455 — cancer biology — Posted on 2025-06-11
619 Better antibodies engineered with a GLIMPSE of human data
Hepler, N. L.; Hill, A. J.; Jaffe, D. B.; Gibbons, M. C.; Pfeiffer, K. A.; Hilton, D. M.; Freeman, M.; McDonnell, W. J.
10.1101/2025.06.08.658113 — bioinformatics — Posted on 2025-06-11
623 Structural and functional characterisation of isolated puff adder (B. arietans) serine proteases
Wilkinson, M. C.; Modahl, C.; Saviola, A.; Tianyi, F.; Harrison, R. A.; Casewell, N. R.
10.1101/2025.06.11.659063 — biochemistry — Posted on 2025-06-11
624 Architecture of the bundle-shaped phycobilisome from Gloeobacter violaceus
Burtseva, A.; Slonimskiy, Y.; Baymukhametov, T.; Sinetova, M.; Maksimov, E. G.; Popov, V. O.; Boyko, K. M.; Sluchanko, N. N.
10.1101/2025.06.10.658930 — biochemistry — Posted on 2025-06-11
625 Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO
Lindsey, G. L.; Hockley, T. K.; Gomez, A. V.; Marshall, A. C.; Brothers, W. R.; Finney, C. T.; Gross, J.; Fox, A. C.; Yeo, G. W.; Melillo, B.; Bond, C. S. S.; Cravatt, B. F.
10.1101/2025.06.10.658857 — biochemistry — Posted on 2025-06-11
628 STING is a key driver of Japanese encephalitis virus induced inflammatory response
Chhabra, S.; Patel, D.; Sharma, K. B.; Sah, V.; Harshan, K.; Chauhan, S.; Kalia, M.
10.1101/2025.06.11.659027 — microbiology — Posted on 2025-06-11
630 The Ambiguous Genetic Code of Methanogenic Archaea that Grow on Methylamines
Shalvarjian, K. E.; Chadwick, G.; Perez, P. I.; Woods, P.; Orphan, V. J.; Nayak, D. D.
10.1101/2025.06.11.659114 — microbiology — Posted on 2025-06-11
635 Mutation or deletion of the Avr6 avirulence effector gene of Fulvia fulva leads to breakdown of the Cf-6 leaf mold resistance locus in tomato
Schol, C. R.; Fokkens, L.; Hu, A.; Jia, R.; de la Rosa, S.; Ökmen, B.; Hilgers, A. M.; van Zwoll, S. L.; Veenendaal, L. D. H.; Turner, M.; Monot, C.; Maeda, K.; Iida, Y.; de Wit, P. J. G. M.; Esselink, D.; Wolters, A.-M. A.; Bai, Y.; Joosten, M. H. A. J.; Mesarich, C. H.
10.1101/2025.06.11.659170 — microbiology — Posted on 2025-06-11
636 Increased basal ganglia volume in older adults with tinnitus
San Martin, S. P.; Medel, V.; Breinbauer, H.; Delgado, C.; Delano, P. H.
10.1101/2025.06.08.658513 — neuroscience — Posted on 2025-06-11
639 High-Throughput Targeted Drug Screening for NF1-associated High-Grade Gliomas with ATRX Deficiency
Dubey, S.; Rai, S.; Guillen, F.; Iyer, A.; Aung, S.; Yuan, M.; Eberhart, C. G.; Rodriguez, F. J.
10.1101/2024.12.14.628525 — cancer biology — Posted on 2025-06-11
640 Fine-Tuning Protein Language Models Unlocks the Potential of Underrepresented Viral Proteomes
Sawhney, R.; Ferrell, B. D.; Dejean, T.; Schreiber, Z.; Harrigan, W.; Polson, S. W.; Wommack, K. E.; Belcaid, M.
10.1101/2025.04.17.649224 — bioinformatics — Posted on 2025-06-11
645 The Sleep-Mood Connection: Temperament Modulates Neuroinflammation, Clock Genes, and Dopaminergic Receptors Expression in Rats
Carvalho, C.; Silva, F. E.; Carvalho, M.; Lima, J. E. C.; Chaves Filho, A. J.; Fries, G.; Sobreira-Neto, M.; Costa, D.; Fonteles, M.; Macedo, D. S.
10.1101/2025.06.09.658634 — animal behavior and cognition — Posted on 2025-06-11
649 American mink as an animal model to study SARS-CoV-2 and vaccine response
Aaltonen, K.; Virtanen, J.; Kegler, K.; Venkat, V.; Kareinen, L.; Korhonen, E. M.; Niamsap, T.; Malmgren, R.; Korpela, J.; Naves, R. A.; Iso-Oja, M.; Svenns, S.; Haggvik, T.; Ojala, E.; Vapalahti, O.; Peura, J.; Sukura, A.; Ritvos, O.; Pasternack, A.; Nordgren, H.; Kant, R.; Sironen, T.
10.1101/2025.06.10.658224 — microbiology — Posted on 2025-06-11
654 EXTENDING PROTEIN LANGUAGE MODELS TO A VIRAL GENOMIC SCALE USING BIOLOGICALLY INDUCED SPARSE ATTENTION
Dejean, T. L.; Sawhney, R.; Harrigan, W.; Ferrell, B. D.; Schreiber, Z.; Polson, S. W.; Wommack, K. E.; Belcaid, M.
10.1101/2025.05.29.656907 — bioinformatics — Posted on 2025-06-11
657 Optimization of Genome-wide CRISPR Screens using dual-guide RNA Infection with Cas9 Electroporation (DICE)
Purman, C.; Lu, C.; Modi, A.; Vijaykumar, V.; Flister, M.; den Hollander, A.; Kadri, S.; Stender, J. D.
10.1101/2025.06.09.658313 — genomics — Posted on 2025-06-11
658 Translation Accuracy in E. coli
Stikeleather, R.; Ali, F.; Ho, W.-C.; Licknack, T.; Lynch, M.
10.1101/2025.04.18.649569 — evolutionary biology — Posted on 2025-06-11
659 Single-cell transcriptional dynamics in a living vertebrate
Eck, E.; Moretti, B.; Schlomann, B. H.; Bragantini, J.; Lange, M.; Zhao, X.; VijayKumar, S.; Valentin, G.; Loureiro, C.; Franco, P. P.; Jollivet, C.; Motomochi, B.; Royer, L. A.; Oates, A. C.; Garcia, H. G.
10.1101/2024.01.03.574108 — developmental biology — Posted on 2025-06-11
662 Ultra-wide-field, deep, adaptive two-photon microscopy
Yang, M.; Zhou, Z.-Q.; Lang, S.; Zheng, H.; Chen, S.; Li, T.; Stas, E.; Zhang, L.; Zhang, Z.; Uzungil, V.; Liu, Q.; Huang, Y.; Jing, L.; Li, Y.; Jia, H.; Li, M.; Li, X.; Li, J.; Tan, Y.; Yan, G.; Schultz, S. R.
10.1101/2025.06.07.658419 — neuroscience — Posted on 2025-06-11
663 Computational enzyme design by catalytic motif scaffolding
Braun, M.; Tripp, A.; Chakatok, M.; Kaltenbrunner, S.; Fischer, C.; Totaro, M. G.; Moser, M.; Stoll, D.; Bijelic, A.; Elaily, W.; Hoch, S. Y. Y.; Lechner, H.; Rossi, F.; Aleotti, M.; Hall, M.; Oberdorfer, G.
10.1101/2024.08.02.606416 — biochemistry — Posted on 2025-06-11
665 Magellon - an extensible platform for cryo-EM data visualization, management, and processing
Khoshbin, B.; Damodar, P.; Garje, R. R.; Schotanus, F. H.; Nair, N.; Wei, L.; Schaefer, J.-H.; Lander, G. C.; Cianfrocco, M. A.; Stagg, S. M.
10.1101/2025.06.09.658726 — biophysics — Posted on 2025-06-11
669 Measles vaccine attenuation comprises innate immune cell infection and interferon responses
Andres, F. G.; Parusel, S.; Siering, O.; Acosta, F. M.; Skeele, D. A.; Ayasoufi, K.; Cattaneo, R.; Sawatsky, B.; Pfaller, C. K.
10.1101/2025.06.09.657851 — immunology — Posted on 2025-06-11
670 Selective targeting of IL-1RAP-dependent eosinophilic inflammation in allergic fungal airway disease
Williams, T. J.; Griffiths, J. S.; Gonzales-Huerta, L. E.; Bell, D.; Reed, A. K.; Shah, A.; Naglik, J. R.; Armstrong-James, D.
10.1101/2025.06.09.658569 — immunology — Posted on 2025-06-11
671 ALOX12B overexpression in the skin drives inflammasome/Th17 signaling axis to promote inflammation in the mouse model and human patients
Singh, S.; Ahmed, F.; Fatima, N.; Cholleti Sai, N.; Bhuktar, H.; Khan, R. A.; Afroz, S.; Battu, S.; Reddy, K. K.; Jagadeb, M.; Naz, S.; Sharma, N.; Philips, A. M.; Priscilla, T.; Vindal, V.; Kumar, M. J. M.; Oruganti, S.; Pal, M.; Reddanna, P.; Khan, N.
10.1101/2025.06.09.658245 — immunology — Posted on 2025-06-11
672 Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis
Georgiev, P.; Johnson, S.; Kurmi, K.; Hu, S.-H.; Han, S.; Patterson, D.; Nguyen, T.; Huang, L.; Liang, D.; Goldman, N.; Conway, T.; Creasey, H.; Rowe, J.; Haigis, M. C.; Sharpe, A. H.
10.1101/2025.06.09.658561 — immunology — Posted on 2025-06-11
674 Oblique Thick Light-Sheet Microscopy with Spatiotemporal 3D Localization for RNA Imaging in Intact 50 μm-Thick Sections
Cai, L.; Song, Q.; Cao, D.; Li, Q.; Wu, W.; Xiao, Y.; Chen, X.; Huang, S.; Yang, J.; Zhang, Y.; Huang, Z.-L.
10.1101/2025.06.09.658547 — biophysics — Posted on 2025-06-11
677 Establishing a standardized genetic toolkit for the radiation-resistant extremophile Deinococcus radiodurans
Simmons, T. R.; Cordova, A.; Grismore, K. B.; Moline, L. C.; Stankes, A. C.; Johnson, J.; Bok, C.; Contreras, L. M.
10.1101/2025.06.09.658681 — bioengineering — Posted on 2025-06-11
679 Optimization of Genome-wide CRISPR Screens using dual-guide RNA Infection with Cas9 Electroporation (DICE)
Stender, J. D.; Purman, C.; Lu, C.; Modi, A.; Vijaykumar, V.; Flister, M.; den Hollander, A.; Kadri, S.
10.1101/2025.06.09.658313 — genomics — Posted on 2025-06-11
680 Defective plasticity in dermatomyositis patients muscle stem cells is associated with sustained intrinsic inflammatory signaling and disruption of the histone H3.3 chromatin loading pathway
Bouchereau, W.; Chenane, L.; Lessard, L.; Weiss-Gayet, M.; Cardona, Y.; Mounier, R.; Gallay, L.; Allenbach, Y.; Benveniste, O.; Corpet, A.; Chazaud, B.; Lomonte, P.
10.1101/2025.06.09.658580 — molecular biology — Posted on 2025-06-11
681 Unlocking River Biofilm Microbial Diversity: A Comparative Analysis of Sequencing Technologies
Anderson, M. A. J.; Thorpe, A. C.; Busi, S. B.; Gweon, H. S.; Warren, J.; Walsh, K.; Read, D. S.
10.1101/2025.06.09.658576 — molecular biology — Posted on 2025-06-11
684 How Ikaros and Aiolos homo- and heterodimers drive gene expression to ensure B cell development
Deau, M.-C.; Heizmann, B.; Aukenova, A.; Heydt, Q.; Marchal, P.; Charvet, C.; le Gras, S.; Billas, I. M. L.; van Essen, D.; Saccani, S.; Kastner, P.; Chan, S.
10.1101/2025.06.09.658591 — immunology — Posted on 2025-06-11
686 DEVELOPMENT OF A POTENT MONOCLONAL ANTIBODY FOR TREATMENT OF HUMAN METAPNEUMOVIRUS INFECTIONS
Harris, E. D.; McGovern, M.; Pernikoff, S.; Ikeda, R.; Kipnis, L.; Hannon, W.; Sobolik, E. B.; Gray, M.; Greninger, A. L.; He, S.; Chin, C.-N.; Fu, T.-M.; Pancera, M.; Boonyaratanakornkit, J.
10.1101/2025.06.09.657676 — immunology — Posted on 2025-06-11
690 Cholesterol-Responsive Interaction of NFE2L1-INSIG1 Controls VLDL Secretion and MASH Pathogenesis
Deng, S.; Freed, J.; Lee, G. Y.; Askin, G.; Cao, Z.; Cakici, O.; Yuan, B.; Hui, S. T.; Graupera, I.; Hotamisligil, G. S.
10.1101/2025.06.09.657856 — physiology — Posted on 2025-06-11
694 Loss of B cell tolerance at the T2/T3a B cell transition is a convergent pathogenic mechanism in common variable immunodeficiency
Hillier, K.; Yuen, G.; Hui, A.; Kumar, S.; Roy, P. G.; McColgan, J.; Zaldana, K.; Premo, K.; Kaneko, N.; Ingram, N.; Barmettler, S.; Ghebremichael, M.; Walter, J. E.; Perugino, C. A.; Das, J.; Farmer, J. R.; Pillai, S.
10.1101/2025.06.07.658167 — immunology — Posted on 2025-06-11
695 EGR3 Deletion Rescues Developmental and Epileptic Encephalopathy in Kcna1-null Mice
Mazumder, A. G.; Karedia, S.; Adhyapak, N.; Bass, J. S.; Kamen, J. L.; Jankovic, M.; Miao, Q.; Gallitano, A. L.; Saltzman, A. B.; Jain, A.; Malovannaya, A.; Glasscock, E.; Aiba, I.; Noebels, J. L.; Krishnan, V.
10.1101/2025.06.07.658422 — neuroscience — Posted on 2025-06-11
698 Bioinspired Oxidized mRNA Lipid Nanoparticles for Ex Vivo Engineering of Chimeric Antigen Receptor Macrophages Targeting Solid Tumors
Mukalel, A. J.; Tylek, T.; O'Brien, E.; Frazee, C.; Geisler, H. C.; Li, J.; Thatte, A. S.; Safford, H. C.; Figueroa-Espada, C. G.; Alameh, M.-G.; Hamilton, A. G.; Mai, D.; Sheppard, N. C.; June, C. H.; Weissman, D.; Spiller, K. L.; Mitchell, M. J.
10.1101/2025.06.07.658363 — bioengineering — Posted on 2025-06-11
699 Structural Identification of Major Molecular Determinants for Phosphotyrosine Recognition in Tyrosine Kinases Reveals Tumour Promoting and Suppressive Functions
Cheng, N.; Millan-Barea, L. R.; Creixell, M.; Barr, A. R.; Kong, Y. W.; Joughin, B. A.; Lopez, C. K.; Lengefeld, J.; Clarke, J.; Liu, C.; Sriram, G.; Gonzalez-Robles, T. J.; van de Kooij, B.; Savickas, S.; Schoof, E. M.; Johnson, J. L.; Bakal, C.; Cantley, L. C.; Chiarle, R.; Pritchard, J.; Hubbard, S.; Huntly, B. J. P.; Hemann, M.; Creixell, P.; Yaffe, M. B.
10.1101/2025.06.10.658871 — biochemistry — Posted on 2025-06-11
702 MAFA Phosphorylation Controls Beta-Cell Identity and Sex-Specific Pancreatic Disease Outcomes
Ka, M.; Druillennec, S.; Chabi, S.; Roulle, C.; NG, D. Y.; PECHOUX, C.; Messaoudi, C.; Walczak, C.; Soler, M.-N.; Besse, L.; Lecoin, L.; Majo, S.; Gradwohl, G.; Eychene, A.; Terris, B.; Pouponnot, C.; DUVILLIE, B.
10.1101/2025.06.11.659123 — cell biology — Posted on 2025-06-11
703 Neural basis of cognitive control signals in anterior cingulate cortex during delay discounting
Seamans, J. K.; Emberly, E.; White, S. M.; Morningstar, M.; Linsenbardt, D. N.; Ma, B.; Czachowski, C. L.; Lapish, C.
10.1101/2024.06.07.597894 — neuroscience — Posted on 2025-06-11
706 Single-cell multi-omic analysis of mesenchymal cells reveals molecular signatures and putative regulators of lung allograft fibrosis
Lu, L.; McLinden, A. P.; Walker, N. M.; Vittal, R.; Wang, Y.; Russell, S. T.; Combs, M. P.; Welch, J. D.; Lama, V. N.
10.1101/2024.11.27.625698 — bioinformatics — Posted on 2025-06-11
709 Cross-species Standardised Cortico-Subcortical Tractography
Assimopoulos, S.; Warrington, S.; Folloni, D.; Bryant, K.; Tang, W.; Jbabdi, S.; Heilbronner, S.; Mars, R. B.; Sotiropoulos, S. N.
10.1101/2025.04.29.651254 — neuroscience — Posted on 2025-06-11
710 Afadin-deficient retinas exhibit severe neuronal lamination defects but preserve visual functions
Ueno, A.; Sakuta, K.; Ono, H.; Hashio, A.; Tokumoto, H.; Watanabe, M.; Nishimoto, T.; Konishi, T.; Emori, Y.; Mizuno, S.; Hiratsuka, M.; Miyoshi, J.; Takai, Y.; Tachibana, M.; Koike, C.
10.1101/2024.12.24.630271 — neuroscience — Posted on 2025-06-11
715 Ultra-wide-field, deep, adaptive two-photon microscopy
Yang, M.; Zhou, Z.-Q.; Lang, S.; Zheng, H.; Chen, S.; Li, T.; Stas, E.; Zhang, L.; Zhang, Z.; Uzungil, V.; Liu, Q.; Huang, Y.; Jing, L.; Li, Y.; Jia, H.; Li, M.; Li, X.; Li, J.; Tan, Y.; Yan, G.; Schultz, S. R.
10.1101/2025.06.07.658419 — neuroscience — Posted on 2025-06-11
718 Evaluating transportability of in-vitro cellular models to in-vivo human phenotypes using gene perturbation data
Howe, L. J.; Aulchenko, Y.; Davey Smith, G.; Davies, N. M.; Esparza Gordillo, J.; Johnson, T.; Liu, J. Z.; Richardson, T. G.; Sanseau, P.; Scott, R. A.; Seaton, D. D.; Sharma, A.; Cortes, A.
10.1101/2024.10.17.618648 — genetics — Posted on 2025-06-11
720 A Molecular, Spatial, and Regulatory Atlas of the Hydra vulgaris Nervous System
Morris Little, H.; Primack, A. S.; Tsverov, J.; Mühlbauer, S.; Cox, B. D.; Busse, C.; Schneid, S.; Louwagie, A.; Cazet, J. F.; David, C. N.; Farrell, J. A.; Juliano, C.
10.1101/2023.03.15.531610 — developmental biology — Posted on 2025-06-11
721 Failed Cellular Surveillance Enables Pathogenic Matrix Deposition in a COL2A1-Related Osteoarthritis
Yammine, K. M.; Abularach, S. M.; Xiong, M.; Kim, S.-y.; Bikovtseva, A. A.; Butty, V.; Schiavoni, R. P.; Bateman, J. F.; Lamande, S. R.; Shoulders, M. D.
10.1101/2024.11.07.622468 — cell biology — Posted on 2025-06-11
722 Microglia Adopt Temporally Specific States after Irradiation, Correlating with Neuronal Asynchrony
Lastra Romero, A.; Preka, E.; Pizzirusso, G.; Arroyo-Garcia, L. E.; Zisiadis, G. A.; Oliva-Vilarnau, N.; Ruchiy, Y.; Seitz, T.; Zhou, K.; Gonzalez Isla, A.; Friess, L.; Sun, Y.; Querol Canut, M.; Shamikh, A.; Xu, Y.; Zhu, C.; Rodrigues, C.; Fisahn, A.; Joseph, B.; Carlson, L.-M.; Fragkopoulou, A.; Lauschke, V.; Betsholtz, C.; Osman, A.; Blomgren, K.
10.1101/2025.02.15.638339 — neuroscience — Posted on 2025-06-11
724 Single-cell multiomics identifies both shared and unique features of immune dysfunction in Parkinson's disease and inflammatory bowel disease colon, plasma and stool
Bolen, M. L.; Buendia, M.; Shi, J.; Staley, H.; Kachergus, J. M.; Efron, P. A.; Park, G.; Nagpal, R.; Alvarez, S. D.; Xue, Q.-S.; McFarland, N. R.; Zimmermann, E. M.; Forsmark, C. E.; Menees, K. B.; Salas, A.; Thompson, E. A.; Tansey, M. G.
10.1101/2025.04.29.651228 — neuroscience — Posted on 2025-06-11
727 Multi-task benchmarking of single-cell multimodal omics integration methods
Liu, C.; Ding, S.; Kim, J. H.; Long, S.; Xiao, D.; Ghazanfar, S.; Yang, P.
10.1101/2024.09.15.613149 — bioinformatics — Posted on 2025-06-11
728 Genomic Insights into a Versatile Deep-Sea Methanotroph Constituting the Rare Biosphere of a Brazilian Carbonate Mound Complex
Butarelli, A. C.; Nakamura, F. M.; Vilela Peres, F.; Modolon da Silva, F.; Bendia, A.; Basti, R.; Mahiques, M.; Sumida, P.; Pellizari, V. H.
10.1101/2025.06.09.658676 — microbiology — Posted on 2025-06-11
729 Small tau aggregates exhibit disease-specific molecular profiles across tauopathies
Böken, D.; Huang, M.; Wu, Y.; Fertan, E.; Lam, J. Y. L.; Meisl, G.; Baig, S.; Rowe, J.; Smith, C.; Quaegebeur, A.; Cox, D.; McEwan, W. A.; Klenerman, D.
10.1101/2025.06.10.658934 — neuroscience — Posted on 2025-06-11
730 Large-scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of α-synuclein aggregation
Neupane, S.; Nikolic, L.; Maraio, L.; Goiran, T.; Karpilovsky, N.; Sellitto, S.; Bouris, V.; Yin, J.-A.; Melki, R.; Fon, E. A.; De Cecco, E.; Aguzzi, A.
10.1101/2025.06.10.658866 — neuroscience — Posted on 2025-06-11
731 Lowering the HTT1a transcript as an effective therapy for Huntingtons disease
Papadopoulou, A. S.; Alterman, J.; Landles, C.; Smith, E. J.; Conroy, F.; Phillips, J.; Canibano-Pico, M.; Nita, I. M.; Osborne, G. F.; Iqbal, A.; Aldous, S. G.; Bondulich, M. K.; Gomez-Paredes, C.; Sathasivam, K.; O'Reilly, D.; Echeverria, D.; Bobkov, K.; Greene, J. R.; Aronin, N.; Khvorova, A.; Bates, G. P.
10.1101/2025.06.10.658804 — neuroscience — Posted on 2025-06-11
737 Scalable 3D Bioprinting of Human Islets in a Pancreatic Decellularized Extracellular Matrix-Enriched Bioink for Beta-Cell Replacement Therapy
Jeong, W.; Perrier, Q.; Rengaraj, A.; Byers, L.; Gonzalez, G. C.; Peveri, E.; Miller, J.; Bottino, R.; Mikhailov, A. V.; Fraker, C.; Opara, E. C.; Tomei, A. A.; Lee, S. J.; Orlando, G.; Asthana, A.
10.1101/2025.06.06.658360 — bioengineering — Posted on 2025-06-11
742 The genome of the charismatic sea star Linckia laevigata
Trimble, C. J.; Laumer, C. E.; Lamare, M.; Carter, H. F.; Byrne, M.; Fellner, M.; Williams, S. T.; Kenny, N. J.
10.1101/2025.06.09.658723 — genetics — Posted on 2025-06-11
746 Introducing PIGMO, a novel PIGmented MOuse model of Parkinson's disease
Chocarro, J.; Marana, S.; Espelosin, M.; Rico, A. J.; Ariznabarreta, G.; Lorenzo-Ramos, E.; Ilarduya, M. M.; Hernandez-Alcoceba, R.; Chillon, M.; Vila, M.; Kordower, J.; Schapira, A. H. V.; Garcia-Osta, A.; Cuadrado-Tejedor, M.; Lanciego, J. L.
10.1101/2025.05.09.653000 — neuroscience — Posted on 2025-06-11
748 Multi-agent AI System for High Quality Metadata Curation at Scale
Mondal, R.; Dhruw, N. K.; Sen, M.; Sengupta, S.; Maity, W.; Palapetta, S.; Jha, A.
10.1101/2025.06.10.658658 — scientific communication and education — Posted on 2025-06-11
749 Tissue-Specific Iron Levels Modulate Lipid Peroxidation and the FLASH Radiotherapy Effect
Vilaplana Lopera, N.; Kim, J.; Nam, G.; Tullis, I. D. C.; Paillas, S.; Ruan, J.-L.; Lee, P. J.; Jiang, Y.; Park, S.; Hou, T.; Nasir, A.; Charlesworth, E.; Walker, E.; Abu-Halawa, A.; Hill, M. A.; Choi, C.; Lee, I. J.; Jeong, Y.; Lakhal-Littleton, S.; Then, C. K.; Shen, S.-C.; Giaccia, A.; Petersson, K.; Moon, E. J.
10.1101/2025.05.14.653978 — cancer biology — Posted on 2025-06-11
752 ATP2B1 expression identifies human hematopoietic stem cells across ontogeny with superior repopulation and self-renewal capacity
Varesi, A.; Nagree, M.; Di Biasio, I.; Zeng, A. G. X.; Shah, S.; Kim, H.; Zhang, M.; Murison, A.; Dick, J. E.; Xie, S. Z.
10.1101/2025.06.11.659017 — cell biology — Posted on 2025-06-11
753 ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chains
Reinders, M.; Kravic, B.; Gahlot, P.; van den Boom, J.; Schulze, N.; Levantovsky, S.; Kleine, S.; Kaiser, M.; Kulathu, Y.; Behrends, C.; Meyer, H.
10.1101/2025.06.10.656592 — cell biology — Posted on 2025-06-11
754 Human meibomian gland organoids to study epithelial homeostasis and dysfunction
Yu, C.; Wan, X.; Wei, J.; Wu, X.; Xu, Z.; Wang, X.; Mi, Y.; Zhang, Y.; Wu, D.; Zhou, X.; Le, Q.; Xu, J.; Zhao, C.; Sun, X.; Zhou, X.; Hong, J.; Zhao, B.
10.1101/2025.06.10.658800 — cell biology — Posted on 2025-06-11
755 The microcephaly-associated protein YIPF5 differentially regulates ER-export
Bruno, F.; Anitei, M.; Di Fraia, D.; Durso, W.; Dau, T.; Cirri, E.; Sannai, M.; Valkova, C.; Maldutyte, J.; Miller, E. A.; Rubio, I.; Garloff, V.; Kersten, N.; Farias, G. G.; Ori, A.; Mestres, I.; Calegari, F.; Kaether, C.
10.1101/2025.06.11.659036 — cell biology — Posted on 2025-06-11
756 The mitochondrial unfolded protein response and metabolic reprogramming promote PASMC proliferation in response to sphingosine kinase-1/sphingosine-1-phosphate signaling
Lockett, A. D.; Snow, A.; Adogamhe, P.; Sysol, J.; Yadav, M.; Mubuuke, T.; Gomes, M. T.; Cook, T.; Fisher, A.; Aldred, M.; Machado, R. F.
10.1101/2025.06.10.658872 — cell biology — Posted on 2025-06-11
759 Dynamic regulation of origin firing factors links CDK activity to dormant origin activation
Hossain, M. S.; Sansam, C. G.; Wittig, K. A.; Noble, T. D.; Boyd, K. A.; Sansam, C. L.
10.1101/2025.06.10.657920 — cell biology — Posted on 2025-06-11
760 TrAEL-seq captures DNA replication dynamics in mammalian cells
Kara, N.; Biggins, L.; Grinkevich, V.; Whale, A.; Garran Garcia, P.; Srinivasan, J.; Rugg-Gunn, P.; Andrews, S.; Parry, A.; Robinson, H. M. R.; Houseley, J.
10.1101/2025.06.09.658559 — molecular biology — Posted on 2025-06-11
762 Maintenance of chronic neuroinflammation in multiple sclerosis via interferon signaling and CD8 T cell-mediated cytotoxicity
Raza, S. A.; Enose-Akahata, Y.; Blazier, A.; Guerra, L. M.; Beck, E. S.; Gaitan, M. I.; Ngouth, N.; Drijvers, J. M.; Dammer, E. B.; Moodley, D.; Johnson, K. R.; Absinta, M.; TURNER, T. J.; Ransohoff, R. M. J.; Jacobson, S.; Ofengeim, D.; Cahir-McFarland, E.; Reich, D. S.
10.1101/2025.06.09.658729 — immunology — Posted on 2025-06-11
764 Circadian Variation in Salivary Oxytocin in young adult women
Teixeira de Almeida, M.; Quattrocchi, L.; Perroud, N.; Aboulafia Brakha, T.
10.1101/2025.03.26.645423 — neuroscience — Posted on 2025-06-11
765 Neural responses underlying ITD discrimination as a function of sensory reliability in the barn owl
Fischer, B. J.; Shadron, K.; Keller, C. H.; Bala, A. D. S.; Cazettes, F.; Ferger, R.; Pena, J. L.
10.1101/2025.06.10.658945 — neuroscience — Posted on 2025-06-11
766 Interdependency between oxytocin and dopamine in trust-based learning in mice
Budniok, S.; Callaerts-Vegh, Z.; Bakermans-Kranenburg, M.; Bosmans, G.; D'Hooge, R.
10.1101/2025.06.11.659016 — neuroscience — Posted on 2025-06-11
767 Brain cholesterol metabolites cause significant neurodegeneration in human iPSC-derived neurons
Feng, Y.; Mazumder, B.; Konno, T.; Hui, E.; Brockhoff, M.; Davi, V.; Lu, M.; Ward, E. N.; Stephens, A.; Dai, W.; Fernandez-Villegas, A.; Fusco, G.; Ali Asgari, M.; Avezov, E.; De Simone, A.; Wang, Y.; Griffiths, W. J.; Kaminski, C. F.; Kaminski Schierle, G. S.
10.1101/2025.06.10.656594 — neuroscience — Posted on 2025-06-11
768 Dynamic regulation of mRNA acetylation at synapses by spatial memory in mouse hippocampus
Zhou, H.-Q.; Zhu, Z.; Zhang, J.-W.; Lin, W.-P.; Jin, H.-J.; Ding, Y.-Y.; Liu, S.; Yin, D.-M.
10.1101/2024.06.01.596932 — neuroscience — Posted on 2025-06-11
771 Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer
Zhang, C.; Zhang, Z.; Wu, Y.; Wu, Y.; Cheng, J.; Luo, K.; Li, Z.; Zhang, M.; Wang, J.; Zhang, X.; Li, Y.
10.1101/2024.05.21.595220 — cancer biology — Posted on 2025-06-11
774 Future climate and land use change will equally impact global terrestrial vertebrate diversity
Hari, C.; Hickler, T.; Hof, C.; Reyer, C. P. O.; Vanderkelen, I.; Voskamp, A.; Biber, M. F.; Fischer, M.; Davin, E. L.
10.1101/2024.12.13.627895 — ecology — Posted on 2025-06-11
775 A globally influential area-condition metric is a poor proxy for invertebrate biodiversity
Duffus, N. E.; Atkins, T. B.; zu Ermgassen, S. O. S. E.; Grenyer, R.; Bull, J. W.; Castell, D. A.; Stone, B.; Tooher, N.; Milner-Gulland, E. J.; Lewis, O. T.
10.1101/2024.10.02.616290 — ecology — Posted on 2025-06-11
776 Nephron segmentation and patterning in kidney organoids can be modulated by distinct FGF subfamily members
Zylberberg, A. K.; Scully, E. I.; Er, P. X.; Baric, H.; Scurr, M.; Xie, M.; Peiris, T.; Howden, S. E.; Lawlor, K. T.; Little, M. H.
10.1101/2025.06.10.658766 — developmental biology — Posted on 2025-06-11
777 Cross-species insemination reveals mouse sperm ability to locate and cross the fish micropyle
Garibova, S.; Stickler, E.; AlAli, F.; Abdulla, M. A.; Sathappan, A.; Da'as, S.; Ghanem, L.; Djekidel, M. N.; Portman, R.; Avella, M.
10.1101/2025.03.29.646094 — developmental biology — Posted on 2025-06-11
778 Transcriptional Dynamics Uncover the Role of BNIP3 in Mitophagy during Muscle Remodeling in Drosophila
Taoka, H.; Murakawa, T.; Kawaguchi, K.; Koizumi, M.; Kaminishi, T.; Sakamaki, Y.; Tanaka, K.; Harada, A.; Inoue, K.; Kanki, T.; Ohkawa, Y.; Fujita, N.
10.1101/2024.12.30.630714 — cell biology — Posted on 2025-06-11
783 A spatial long-read approach at near-single-cell resolution reveals developmental regulation of splicing and polyadenylation sites in distinct cortical layers and cell types.
Foord, C.; Prjibelski, A. D.; Hu, W.; Michielsen, L.; Vandelli, A.; Narykov, O.; Evans, B.; Hsu, J.; Belchikov, N.; Jarroux, J.; He, Y.; Ross, M. E.; Hajirasouliha, I.; Tartaglia, G. G.; Korkin, D.; Tomescu, A. I.; Tilgner, H. U.
10.1101/2025.06.10.658877 — genomics — Posted on 2025-06-10
784 Quantitative trait loci mapping of gene expression and chromatin accessibility in primary fibroblast reveals shared allelic effects between Latin American and European ancestries
Boltz, T.; Bot, M.; Lapinska, S.; Schwarz, T.; Hou, K.; Garske, K. M.; Freund, M. K.; Bearden, C. E.; Macaya, G.; Lopez-Jaramillo, C.; Freimer, N. B.; Boks, M. P.; Kahn, R. S.; Pasaniuc, B.; Ophoff, R. A.
10.1101/2025.06.09.658613 — genomics — Posted on 2025-06-10
785 Deciphering the dynamic proteome of multiciliated cells
Boutin, C.; Rosnet, O.; Touret, M.; Audebert, S.; Camoin, L.; Dussert, S.; Brouilly, N.; Thome, V.; Fortun, D.; Borg, J.-P.; Kodjabachian, L.
10.1101/2025.06.10.658933 — cell biology — Posted on 2025-06-10
786 A Foraging-Theory-Based Model Captures the Spectrum of Human Behavioral Diversity in Sequential Decision Making
Harrell, D.; Zid, M.; Laurie, V.-J.; Chen, C.; Grissom, N.; Darrow, D. P.; Ebitz, B. R.; Herman, A. B.
10.1101/2025.05.06.652482 — neuroscience — Posted on 2025-06-10
788 CRISPR-mediated knockdown of oxytocin receptor in extended amygdala reduces stress-induced social avoidance and vigilance
Salazar, V. C.; Boender, A.; Seelke, A.; Gaard, L.; Mederos, S.; Rogers, S.; Gutierrez, X.; Bales, K.; Young, L.; Trainor, B. C.
10.1101/2025.06.10.658921 — neuroscience — Posted on 2025-06-10
790 Essentialome-Wide Multigenerational Imaging Reveals Mechanistic Origins of Cell Growth Laws
Eaton, D. S.; Sanchez, C.; Gutierrez-Lopez, L.; Shenker, J. Q.; Goulev, Y.; Watson, B. R.; Henriot, V.; Garner, E. C.; Justman, Q. A.; Moffitt, J. R.; Paulsson, J.
10.1101/2025.06.10.658525 — systems biology — Posted on 2025-06-10
791 Sex Differences in the Cancer Proteome
Zhu, C.; Zeltser, N.; Oh, J.; Li, C. H.; Boutros, P. C.
10.1101/2025.03.14.643396 — cancer biology — Posted on 2025-06-10
792 Senescent human fibroblasts have increased FasL expression and impair the tumor immune response
Cruz, M.; Dulong, J.; Mansour Nehmo, G.; Sonn, A.; Moquin-Beaudry, G.; Benabdallah, B.; Le, O.; Beausejour, C.
10.1101/2024.06.10.598270 — cancer biology — Posted on 2025-06-10
793 Fine-Tuning Protein Language Models Unlocks the Potential of Underrepresented Viral Proteomes
Dejean, T.; Sawhney, R.; Ferrell, B. D.; Schreiber, Z.; Harrigan, W.; Polson, S. W.; Wommack, K. E.; Belcaid, M.
10.1101/2025.04.17.649224 — bioinformatics — Posted on 2025-06-10
795 Intervertebral disc impairments in a mouse model of Alzheimer's Disease
Gonzalez, C. C.; Schurman, C. A.; Wilson, K. A.; Schilling, B.; Ellerby, L. M.; Tang, S. Y.
10.1101/2025.05.24.655931 — bioengineering — Posted on 2025-06-10
796 Genetic differences in plasticity across environmental scales determine fitness along an ecological gradient
Walter, G. M.; Emma, G.; Terranova, D.; Clark, J.; Cozzolino, S.; Hiscock, S.; Cristaudo, A.; Bridle, J.
10.1101/2025.03.19.644087 — evolutionary biology — Posted on 2025-06-10
799 Immune-mediated inflammation modulates the thalamostriatal circuitry regulating depression-like behaviour in both mice and humans
Sharma, D.; Andrianova, L.; McGonigal, R.; Gardner-Stephen, K.; al Fadhel, H.; Sunzini, F.; Stefanov, K.; Barrie, J. A.; Hohne, R.; Saathoff, M.; Karabalci, Y.; Montes Gomez, A.; Bourgognon, J.-M.; Thornton, P.; Basu, N.; Cole, J. J.; Craig, M. T.; Cavanagh, J. T.
10.1101/2024.06.26.600791 — neuroscience — Posted on 2025-06-10
804 Identification of a new inhibitor of Ran GTPase with therapeutic value in epithelial ovarian cancer
Boudhraa, Z.; Tian, X.; Gam, R.; Ritch, S.; Kendall-Dupont, J.; Carmona, E.; Provencher, D.; Wu, J. H.; Mes-Masson, A.-M.
10.1101/2025.03.02.641080 — cancer biology — Posted on 2025-06-10
807 mRNArchitect: sequence design of mRNA medicines
Budzinska, M. A.; Zardbani, M.; Sidharta, M. P.; Waterhouse, J.; Leonard, T. E.; Ghodasara, A.; Lakshman Das, S.; Chang, R. Y.; Chaudhary, N.; Cheetham, S. W.; Mercer, T. R.; Gunter, H. M.
10.1101/2024.12.03.626696 — bioinformatics — Posted on 2025-06-10
808 Listen, who is it? A novel method for studying the nightly and annual phenologies of cave bat communities in data deficient areas of the world.
Labadie, M.; Morand, S.; Caron, A.; De Nys, H. M.; Niama, F. R.; Nguilili, F.; TOBI, N.-; Bourgarel, M.; Bas, Y.; Roemer, C.
10.1101/2025.02.22.639615 — ecology — Posted on 2025-06-10
809 Nephron segmentation and patterning in kidney organoids can be modulated by distinct FGF subfamily members
Zylberberg, A. K.; Scully, E. I.; Er, P. X.; Baric, H.; Scurr, M.; Xie, M.; Peiris, T.; Howden, S. E.; Lawlor, K. T.; Little, M. H.
10.1101/2025.06.10.658766 — developmental biology — Posted on 2025-06-10
810 Neural crest induction requires SALL4-mediated BAF recruitment to lineage specific enhancers
Demurtas, M.; Barnada, S. M.; Van Domselaar, E.; Mitchell, Z. H.; Deelen, L. L.; Trizzino, M.
10.1101/2025.06.10.658805 — developmental biology — Posted on 2025-06-10
813 Perirhinal cortex structure and function is dysregulated by corticosteroid treatment
Claydon, M. D. B.; Troy, O.; Birnie, M. T.; Kershaw, Y. M.; Barker, G. R. I.; Warburton, E. C.; Bortolotto, Z. A.; Lightman, S. L.; Conway-Campbell, B. L.
10.1101/2025.06.06.658287 — neuroscience — Posted on 2025-06-10
816 Spatial Image Gradient Estimation from the Diffusion MRI Profile
Aganj, I.; Feiweier, T.; Kirsch, J. E.; Fischl, B. R.; van der Kouwe, A. J.
10.1101/2025.06.06.658348 — bioengineering — Posted on 2025-06-10
817 Structural basis of RNA-guided transcription by a dCas12f-σE-RNAP complex
Xiao, R.; Hoffmann, F. T.; Xie, D.; Wiegand, T.; Palmieri, A. I.; Sternberg, S. H.; Chang, L.
10.1101/2025.06.10.658880 — biochemistry — Posted on 2025-06-10
818 Purification of post-transcriptionally modified tRNAs for enhanced cell-free translation systems
Kalb, E.; Alejo, J.; Dias-Fields, L.; Knudson, I.; Davisson, J.; Maldonado, E.; Chattrakun, K.; Lin, S.; Schepartz, A.; Zhang, S.; Blanchard, S.; Engelhart, A. E.; Adamala, K. P.
10.1101/2025.06.10.658963 — biochemistry — Posted on 2025-06-10
819 Early life environments shape adult cardiometabolic health during rapid lifestyle change
Petersen, R. M.; Tennyson, R.; A/P Tan Boon Huat, T. B. T.; Tam, K. L.; Watowich, M. M.; Solhaimi bin Fadzil, K.; Nicholas, C.; bin Mohd Sayed, I.; Seong Ng, K.; A L Lim, Y.; Venkataraman, V. V.; Wallace, I. J.; Kraft, T. S.; Lea, A. J.
10.1101/2025.06.06.658350 — evolutionary biology — Posted on 2025-06-10
820 Alveolar epithelial cell plasticity and injury memory in human pulmonary fibrosis
Adams, T. S.; Schupp, J. C.; Balayev, A.; Khoury, J.; Justet, A.; Nikola, F.; Laurens, D. S. J.; Garcia, J. C.; Zapata-Ortega, M.; Panayiotis, B. V.; McDonough, J. E.; Ahangari, F.; Koenigshoff, M.; Ding, J.; Homer, R. J.; Rosas, I. O.; Yan, X.; Vanaudenaerde, B. M.; Wuyts, W. A.; Kaminski, N.
10.1101/2025.06.10.658504 — cell biology — Posted on 2025-06-10
821 APOBEC3A deaminase catalyzes site-specific editing of transfer RNAs
Hoffa-Sobiech, K.; Sikora, J.; Ruszkowski, M.; Starczak, M.; Gackowski, D.; Blaszczak, A.; Mierzwa, A.; Rakoczy, M.; Marcinkowska-Swojak, M.; Stolarek, I.; Jackowiak, P.; Figlerowicz, M.; Budzko, L.
10.1101/2025.06.10.658825 — molecular biology — Posted on 2025-06-10
822 Exapted CRISPR-Cas12f homologs drive RNA-guided transcription
Hoffmann, F. T.; Wiegand, T.; Palmieri, A. I.; Glass-Klaiber, J.; Xiao, R.; Tang, S.; Le, H.; Meers, C.; Lampe, G. D.; Chang, L.; Sternberg, S. H.
10.1101/2025.06.10.658865 — molecular biology — Posted on 2025-06-10
823 The unique molecular recognition features of Siglec-10: structural insights into sialoglycan and antibody interactions
Sobczak, K.; Antonana-Vildosola, A.; Valverde, P.; Travecedo, M. A.; Jame-Chernaboo, Z.; Schmidt, E. N.; DAndrea, S.; Valdaliso-Diez, E.; Oyenarte, I.; Laugieri, M. E.; Joe, M.; Mozaneh, F.; Lin, S.-Y.; Bosch, A.; Moure, M. J.; Franconetti, A.; Lee, S. Y.; Etxaniz-Diaz de Durana, J.; Perez-Gutierrez, L.; Palazon, A.; Marcelo, F.; Fadda, E.; Corzana, F.; Gimeno, A.; Macauley, M. S.; Jimenez-Barbero, J.; Ereno-Orbea, J.
10.1101/2025.06.10.658867 — molecular biology — Posted on 2025-06-10
824 A male-drive female-sterile system for the self-limited control of the malaria mosquito Anopheles gambiae
Bernardini, F.; Strampelli, A.; Willis, K.; Gulliford, H. R.; Gribble, M.; Fasulo, B.; Burt, A.; Crisanti, A.
10.1101/2025.06.10.658817 — molecular biology — Posted on 2025-06-10
826 Salmonella hijacks a host glucose transporter for intravacuolar proliferation
Fang, X.; Shi, L.; Ding, Y.; Wang, Y.; Chen, W.; Xue, J.; Wang, L.; Hui, Y.; Tao, X.; Yang, J.; Du, L.; Xie, D.; Meng, K.
10.1101/2025.06.10.658782 — microbiology — Posted on 2025-06-10
828 Light-harvesting by antenna-containing xanthorhodopsin from an Antarctic cyanobacterium
Marin Perez, M. d. C.; Murakoshi, S.; Rozenberg, A.; Tanaka, T.; Konno, M.; Shihoya, W.; Nureki, O.; Inoue, K.; Beja, O.
10.1101/2025.06.10.658827 — microbiology — Posted on 2025-06-10
829 Plastic-Degrading Clusters of Orthologous Groups in Prokaryotes
Mustari, S.; Pham, L. T.; Saikkonen, K.; Nakamura, M.; Puigbo, P.
10.1101/2025.06.10.658834 — microbiology — Posted on 2025-06-10
831 Intelectin-2 is a broad-spectrum antimicrobial lectin
Dugan, A. E.; Syangtan, D.; Nonnecke, E. B.; Chorghade, R. S.; Peiffer, A. L.; Yao, J. J.; Ille-Bunn, J.; Sergio, D.; Pishchany, G.; Dhennezel, C.; Vlamakis, H.; Bae, S.; Johnson, S.; Ellis, C.; Ghosh, S.; Alty, J. W.; Barnes, C. E.; Krupkin, M.; Carcamo-Oyarce, G.; Ribbeck, K.; Xavier, R. j.; Bevins, C. L.; Kiessling, L. L.
10.1101/2025.06.09.658748 — microbiology — Posted on 2025-06-10
832 The DanRI regulatory system in uropathogenic Escherichia coli subverts neutrophil responses
Cerina, D.; Rousseau, M.; Olaiz, C. H.; Marsman, G.; Zychlinsky, A.; Ingersoll, M. A.
10.1101/2025.06.10.658900 — microbiology — Posted on 2025-06-10
835 4-Nitrobenzoate inhibits 4-hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy
Verdaguer, I. B.; Santos, M. F.; Mazzine Filho, M.; Castro, G. O.; Hernandez, A.; Peres, M. A.; Katzin, A. M.; Crispim, M.
10.1101/2025.06.10.658244 — microbiology — Posted on 2025-06-10
836 Impaired envelope integrity in the absence of SanA is linked to increased Lipid II availability and an imbalance of FtsI and FtsW activities
Carr, J. F.; De Santiago, C. B.; Bhut, S.; Warzecha, D. J.; Wei, R.; Herrera, C.; Trent, M. S.; Nan, B.; Mitchell, A.
10.1101/2025.06.10.658892 — microbiology — Posted on 2025-06-10
837 Proposal of two new genera and seventy-seven new species of ascomycetous yeasts isolated from China
Zhu, H.-H.; Li, A.-H.; Liu, M.-M.; Jiang, Y.-L.; Zhao, X.-M.; Pan, S.; Liu, J.-H.; Zhang, X.-H.; Wang, J.-C.; Tian, Z.-Y.; Wang, G.-S.; Guo, Y.-T.; Phurbu, D.; Bai, F.-Y.; Wang, Q.-M.
10.1101/2025.06.10.658801 — microbiology — Posted on 2025-06-10
839 Ionic Mechanisms Underlying Bistability in Spinal Motoneurons: Insights from a Computational Model
Molkov, Y.; Krust, F.; Jeter, R.; Stell, T.; Mohammed, M. A. Y.; Brocard, F.; Rybak, I.
10.1101/2025.06.06.658369 — neuroscience — Posted on 2025-06-10
840 Dual effect of alpha-synuclein disease variants on condensate formation
Chandran, A.; Agarwal, A.; Wang, T.; Amaral, L.; Chaves, S. R.; Outeiro, T. F.; Lautenschlager, J.
10.1101/2025.06.06.657340 — neuroscience — Posted on 2025-06-10
841 Voluntary movement initiation is associated with cardiac input in Libet's task.
Germanova, K.; Studenova, A.; Bredikhin, D.; Gippert, M.; Kapralov, N.; Klucharev, V.; Villringer, A.; Herrojo Ruiz, M.; Nikulin, V.
10.1101/2025.06.06.658322 — neuroscience — Posted on 2025-06-10
845 Topological stratification of continuous genetic variation in large biobanks
Diaz-Papkovich, A.; Zabad, S.; Ben-Eghan, C.; Anderson-Trocme, L.; Femerling, G.; Nathan, V.; Patel, J.; Gravel, S.
10.1101/2023.07.06.548007 — genomics — Posted on 2025-06-10
846 Subclonal mutation load predicts survival and response to immunotherapy in cancers with low to moderate tumor mutation burden
Jiang, Y.; Montierth, M. D.; Yu, K.; Ji, S.; Tran, Q.; Liu, X.; Shen, J. P.; Guo, S.; Wu, A.; Dai, Y.; Shin, S. J.; Li, R.; Cao, S.; Tang, Y.; Lesluyes, T.; Kopetz, S.; Msaouel, P.; Sood, A. K.; Devonshire, G.; Jones, C. M.; Ajani, J.; Subudhi, S. K.; Aparicio, A.; Sharma, P.; Shen, J. P.; Kimmel, M.; Wang, J. R.; Tarabichi, M.; Fitzgerald, R. C.; Zhu, H.; Loo, P. V.; Wang, W.
10.1101/2024.07.03.601939 — genomics — Posted on 2025-06-10
847 Warning signals for the long-term innovative potential of genetic research based on 20 million papers and patents
Chae, J.; Kim, W.; Jung, W.; Jeong, D.; Lim, R.; Chamlagain, M.; Jung, G.; Jang, J.; Lee, J. W.; Kang, N. K.; Baek, K.; Shin, J.; Lee, Y.-G.; Koh, H. G.; Kim, C.; Yook, S.; Cheung, A. K. L.; Jin, Y.-S.; Youn, H.; Kim, P.-J.; Ghim, C.-M.
10.1101/2025.02.17.638429 — scientific communication and education — Posted on 2025-06-10
849 The architecture of resilience: a genome assembly of Myrothamnus flabellifolia sheds light on desiccation tolerance and sex determination
Marks, R. A.; Lovell, J. T.; Carey, S. B.; Van Der Pas, L.; Chimukuche, N. M.; Bruna, T.; Plott, C.; Webber, J.; Lipzen, A.; Yan, J.; Bauer, D.; Bentley, J.; Talag, J.; Barry, K.; Grimwood, J.; Jenkins, J. W.; Schmutz, J.; Harkess, A.; VanBuren, R.; Leebens-Mack, J.; Farrant, J. M.
10.1101/2025.06.02.657439 — plant biology — Posted on 2025-06-10
850 Defense-Suppressive Fragments of RIN4 generated by AvrRpt2 Participate in NDR1-dependent Activation of RPS2
Afzal, A. J.; Alam, M.; Huang, J.; Agha, M.; Da Cunha, L.; Iqbal Rai, M.; Tahir, J.; Jamroze, A.; Jones, J. D.; Mackey, D.
10.1101/2025.06.02.656948 — plant biology — Posted on 2025-06-10
851 Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism
Godfrey, W. H.; Lee, J. J.; Shanmukha, S.; Cho, K.; Deng, X.; Ambati, C. S. R.; Putluri, V.; Kamal, A. H. M.; Kim, P. M.; Putluri, N.; Kornberg, M. D.
10.1101/2024.06.23.600101 — immunology — Posted on 2025-06-10
853 Synaptic vesicles that store monoamines and glutamate differ in protein composition.
Asmerian, H.; Diaz, A. J.; Xu, H.; Oses-Prieto, J. A.; Alberts, J.; Sanetra, A. M.; Gnanabharathi, B.; Carr, N.; Burlingame, A. L.; Edwards, R. H.; Silm, K.
10.1101/2025.05.06.651945 — neuroscience — Posted on 2025-06-10
854 Ras-dependent activation of BMAL2 regulates hypoxic metabolism in pancreatic cancer
Curiel-Garcia, A.; Holmstrom, S.; Castillo, C.; Palermo, C. F.; Sastra, S. A.; Andren, A.; Tomassoni, L.; Li, Z.; LeLarge, T.; Sagalovskiy, I.; Ross, D. R.; Wong, W.; Shaw, K.; Genkinger, J.; Hibshoosh, H.; Manji, G. A.; Iuga, A.; Schmid, R. M.; Johnson, K.; Badgley, M. A.; Laise, P.; Lyssiotis, C.; Shah, Y. M.; Califano, A.; Maurer, H. C.; Olive, K. P.
10.1101/2023.03.19.533333 — cancer biology — Posted on 2025-06-10
861 Linking biotic interactions to species stability
Lajaaiti, I.; Kefi, S.; Loreau, M.; Ardichvili, A.; Arnoldi, J.-F.
10.1101/2025.03.25.645234 — ecology — Posted on 2025-06-10
862 Growth and patterning in vertebrate limb developmentA timescale perspective on skeletal specification
Ben Tahar, S.; Comellas, E.; Duerr, T. J.; Bakr, D.; Monaghan, J. R.; Munoz, J. J.; Shefelbine, S. J.
10.1101/2025.03.20.644440 — developmental biology — Posted on 2025-06-10
864 Unraveling Regulatory Feedback Mechanisms in Adult Neurogenesis Through Mathematical Modelling
Danciu, D.-P.; Klawe, F. Z.; Kazarnikov, A.; Femmer, L.; Kostina, E.; Martin-Villalba, A.; Marciniak-Czochra, A.
10.1101/2025.03.12.642763 — systems biology — Posted on 2025-06-10
865 Tick extracellular vesicles alter keratinocyte function in the skin epidermis
Marnin, L.; Valencia, L.; Bogale, H.; Laukaitis-Yousey, H.; Rolandelli, A.; Ferraz, C. R.; O'Neal, A. J.; Schmitter-Sanchez, A.; Bencosme Cuevas, E.; Nguyen, T.-T.; Leal-Galvan, B.; Rickert, D. M.; Mendes, M. T.; Samaddar, S.; Butler, L. R.; Singh, N.; Cabrera Paz, F.; Wu-Chuang, A.; Oliver, J.; Jameson, J.; Munderloh, U.; Oliva Chavez, A.; Mulenga, A.; Park, S.; Serre, D.; Pedra, J. H. F.
10.1101/2023.11.10.566612 — microbiology — Posted on 2025-06-10
866 Effects of diffusion MRI spatial resolution on human brain short-range association fiber reconstruction and structural connectivity estimation
Zheng, J.; Li, Z.; Zhong, W.; Wang, Z.; Li, Z.; Yang, H.; Liu, M.; Cao, X.; Liao, C.; Salat, D. H.; Huang, S. Y.; Tian, Q.
10.1101/2025.06.04.657810 — neuroscience — Posted on 2025-06-10
871 Antimicrobial stewardship in animal health: experience-based co-design framework to capture progress and accelerate improvement
Hewson, K. A.; Binet, M.; Richards, K.; Gleeson, B.; Adsett, S.; Tuckett, G.; Kennedy, B.; Jenner, R.; Courtice, J.; Batterham, T.; Page, S. W.; Britton, S.
10.1101/2025.06.03.657743 — microbiology — Posted on 2025-06-10
875 The phonology of sperm whale coda vowels
Begus, G.; Dabkowski, M.; Sprouse, R.; Gruber, D.; Gero, S.
10.1101/2025.06.09.658556 — animal behavior and cognition — Posted on 2025-06-10
879 Optimizing a Human Monoclonal Antibody for Better Neutralization of SARS-CoV-2
Wang, Q.; Guo, Y.; Casner, R. G.; Yu, J.; Nair, M. S.; Ho, J.; Reddem, E. R.; Mellis, I. A.; Wu, M.; Tzang, C. C.; Hong, H.; Huang, Y.; Shapiro, L.; Liu, L.; Ho, D. D.
10.1101/2024.12.04.626800 — microbiology — Posted on 2025-06-10
881 All spectral frequencies of neural activity reveal semantic representation in the human anterior ventral temporal cortex
Frisby, S. L.; Halai, A. D.; Cox, C. R.; Clarke, A.; Shimotake, A.; Kikuchi, T.; Kuneida, T.; Arakawa, Y.; Takahashi, R.; Ikeda, A.; Matsumoto, R.; Rogers, T. T.; Lambon Ralph, M. A.
10.1101/2025.04.17.649404 — neuroscience — Posted on 2025-06-10
882 Hepatic retromer is essential for systemic cholesterol homeostasis by regulating lysosomal cholesterol metabolism
Vos, D. Y.; Barbosa, M. G.; Heida, A. H.; Caillaud, A.; Tissink, J. J.; Koster, M. H.; Smit, M.; Huijkman, N.; Kloosterhuis, N. J.; Girardeau, A.; Berue-Racape, Z.; Bloks, V. W.; Havinga, R.; Fuh, M. M.; Reggiori, F.; Mari, M.; Scheja, L.; Heeren, J.; Kuipers, F.; de Boer, J. F.; Rimbert, A.; Wolters, J. C.; Kuivenhoven, J. A.; Verzijl, C.; van de Sluis, B.
10.1101/2023.08.09.552611 — molecular biology — Posted on 2025-06-10
886 Neural crest induction requires SALL4-mediated BAF recruitment to lineage specific enhancers
Demurtas, M.; Barnada, S. M.; Van Domeslaar, E.; Mitchell, Z. H.; Deelen, L. L.; Trizzino, M.
10.1101/2025.06.10.658805 — developmental biology — Posted on 2025-06-10
889 Layer 6 is a hub for cholinergic modulation in the mouse auditory cortex
Vattino, L. G.; Clayton, K. K.; Hackett, T. A.; Takesian, A. E.; Polley, D. B.
10.1101/2025.06.09.658740 — neuroscience — Posted on 2025-06-10
890 FOXP1 differentially regulates the development of murine vasopressin and oxytocin magnocellular neurons
Berkhout, J.; Trender, S.; Krabichler, Q.; Podpecan, Y.; Franke, F.; Schubert, T.; Burbach, P.; Grinevich, V.; Adan, R.; Fröhlich, H.; Althammer, F.; Meijer, O.; Mahfouz, A.
10.1101/2025.06.10.658830 — neuroscience — Posted on 2025-06-10
894 Acute anaphylactic and multiorgan inflammatory effects of Comirnaty in pigs: evidence of spike protein mRNA transfection and paralleling inflammatory cytokine upregulation
Dezsi, L.; Kokeny, G.; Szeneasi, G.; Revesz, C.; Meszaros, T.; Barta, B.; Facsko, R.; Szilasi, A.; Bakos, T.; Kozma, G. T.; Dobos, A.; Merkely, B.; Radovits, T.; Szebeni, J.
10.1101/2025.06.07.658379 — immunology — Posted on 2025-06-10
896 Hyperpolarization activated cation channel mediated intrinsic plasticity changes underlie the malleability of with-in cell-type electrophysiological heterogeneity
Chameh, H. M.; Falby, M.; Yang, Y.; Movahed, M.; Arbabi, K.; Sarathy, C.; Tripathy, S. J.; Zhang, L.; Lefebvre, J.; Valiante, T. A.
10.1101/2025.06.09.658517 — neuroscience — Posted on 2025-06-10
900 The Desmoglein 2 interactome in primary neonatal cardiomyocytes
Li, Y.; Campbell, A. P.; Balasubramanian, S.; Zeng, X.; Porter, E.; Cantrell, P. S.; Sun, M.; Mattheyses, A. L.; Kwiatkowski, A. V.
10.1101/2025.06.09.658637 — cell biology — Posted on 2025-06-10
902 Electron tomography reveals mitochondrial network and cristae remodelling during cell differentiation in the human placenta
Acharya, S.; Hanssen, E.; Botha, V. B.; Smith, T. M.; Jayatissa, S.; Trifunovic, Z.; Bartho, L. A.; Schjenken, J. E.; Kaitu'u-Lino, T. J.; Perkins, A. V.; James, J. L.; Pringle, K. G.; Bouwer, J. C.; Smith, R.; Fisher, J. J.
10.1101/2025.06.09.658204 — cell biology — Posted on 2025-06-10
903 Neuronal migration induces DNA damage in developing brain
Zhang, Z.; Canela, A.; Zou, P.; Furuta, T.; Takeda, N.; Kawaue, T.; Nakazawa, N.; Saeki, M.; Utsunomiya, M.; Kurisu, J.; Ishidate, F.; Sasanuma, H.; Kishi, Y.; Kengaku, M.
10.1101/2025.06.10.658810 — cell biology — Posted on 2025-06-10
909 Volumetric single-molecule tracking inside subcellular structures
Daly, S.; Chambers, J. E.; Jones, C.; Fu, B.; Manton, J. D.; Beckwith, J. S.; Marciniak, S. J.; Gershlick, D. C.; Lee, S. F.
10.1101/2025.06.09.658280 — biophysics — Posted on 2025-06-10
910 Secondary structure transitions and dual PIP2 binding define cardiac KCNQ1-KCNE1 channel gating
Zhong, L.; Lin, X.; Cheng, X.; Wan, S.; Hua, Y.; Nan, W.; Hu, B.; Yan, Z.; Jiang, D.; Zhang, H.; Liu, F.; Xiao, C.; Zhou, Z.; Yu, H.; Ma, L.; Huang, C.; Wong, K. W.; Chung, S. K.; Shen, B.; Jiang, Z.-H.; Neher, E.; Zhu, W.; Zhang, J.; Hou, P.
10.1101/2025.06.10.657059 — biophysics — Posted on 2025-06-10
911 Phosphorylation Toggles the SARS-CoV-2 Nucleocapsid Protein Between Two Membrane-Associated Condensate States
Favetta, B.; Wang, H.; Cubuk, J.; Singh, A.; Barai, M.; Ramirez, C.; Gormley, A. J.; Murthy, S.; Dignon, G.; Soranno, A.; Shi, Z.; Schuster, B. S.
10.1101/2024.10.17.618867 — biophysics — Posted on 2025-06-10
913 Large adipocytes in a biomimetic adipose tissue model promote breast cancer malignancy
Beeghly, G. F.; Pincus, M. I.; Varshney, R. R.; Giri, D. D.; Falcone, D. J.; Rudolph, M. C.; Antonyak, M. A.; Iyengar, N. M.; Fischbach, C.
10.1101/2025.03.28.645549 — bioengineering — Posted on 2025-06-10
924 Pcbp1 orchestrates amino acid metabolism burst during the naive-to-primed pluripotency transition
Bakhmet, E. I.; Potapenko, E. V.; Shuvalov, O. Y.; Lobov, A. A.; Repkin, E. A.; Vorobyeva, N. E.; Korablev, A. N.; Zinovyeva, A. S.; Kuzmin, A. A.; Aksenov, N. D.; Kopylov, A. T.; Wu, G.; Schoeler, H. R.; Tomilin, A. N.
10.1101/2025.06.07.658314 — developmental biology — Posted on 2025-06-10
925 Developmental Emergence of Replay-DMN Coordination Predicts Entorhinal Grid Codes
Pang, L.; Qu, Y.; Ou, J.; Wu, S.; Luo, Y.; Gohil, C.; Woolrich, M.; Behrens, T.; Liu, Y.
10.1101/2025.04.02.646732 — neuroscience — Posted on 2025-06-10
926 FRA1 drives melanoma metastasis through an actionable transcriptional network
Xu, X.; Chadourne, M.; Soto-Vargas, Z.; Jarajapu, V.; Yao, J.; Yu, X.; Karreth, F. A.
10.1101/2025.06.07.658418 — cancer biology — Posted on 2025-06-10
927 Treatment Resistant Persister Cells Exploit Macrophage Lipid Metabolism to Sustain Glioblastoma Growth
Chakraborty, A.; Yang, C.; Silver, A.; Feier, D.; Tian, G.; Pittu, A.; Roemeling, C. V.; Thomas, N.; Andrews, M.; Conforti, C.; Sobanjo, O. O.; Searl, N. T.; Anica, M. N.; McTiernan, R.; Rahman, M.; Huang, J.; Harrison, J. K.; Mitchell, D. A.; Sarkisian, M.; Deleyrolle, L. P.
10.1101/2025.06.07.658345 — cancer biology — Posted on 2025-06-10
928 Cut-Detector: A Tool for Automated Temporal Analysis of Late Cytokinetic Events
Bonte, T.; Dubois, L.; Gagna, P.; Dibsy, R.; Petrovic, A.; Advedissian, T.; Serres, M.; Cuvelier, F.; Crouigneau, M.; Sassoon, N.; Gupta-Rossi, N.; Fremont, S.; Echard, A.; Walter, T.
10.1101/2025.06.06.658046 — bioinformatics — Posted on 2025-06-10
929 Decoding PDI diversity: insights into structure, domains, and functionality in sorghum
Lopez Gomez, C. F.; Morris, M. T.; Massel, K.; Smith, M.; Crisp, P.; Schenk, G.; Godwin, I. D.
10.1101/2025.06.06.658324 — bioinformatics — Posted on 2025-06-10
931 Monalisa: An Open Source, Documented, User-Friendly MATLAB Toolbox for Magnetic Resonance Imaging Reconstruction
Leidi, M.; Jia, Y.; Helbing, D.; Barranco, J.; Acikgoz, B. C.; Peper, E.; Ledoux, J.-B.; Bastiaansen, J. A. M.; Franceschiello, B.; Milani, B.
10.1101/2025.06.06.658299 — bioinformatics — Posted on 2025-06-10
932 Female Moths Incorporate Plant Acoustic Emissions into Their Oviposition Decision
Seltzer, R.; Zer Eshel, G.; Yinon, O.; Hafani, A.; Eitan, O.; Matveev, S.; Levedev, G.; Davidovitz, M.; Ben Tov, T.; Sharabi, G.; Shapira, Y.; Shvil, N.; Atallah, I.; Hadad, S.; Ment, D.; Hadany, L.; Yovel, Y.
10.1101/2024.11.06.622209 — animal behavior and cognition — Posted on 2025-06-10
933 The Population Genetics of Biological Noise
Weinreich, D. M.; Sgouros, T.; Raynes, Y.; Burtsev, H.; Chang, E.; Rajakumar, S.; Bravo, I. G.; Petak, C.
10.1101/2025.01.11.632402 — evolutionary biology — Posted on 2025-06-10
936 Harnessing Random Peptide Mixtures to Overcome Multidrug-Resistant Fungal Infections
Adeoye, J.; Belo, Y.; Rocha, M.; Hayby, H.; Israyilova, A.; Hayouka, Z.; Shlezinger, N.
10.1101/2024.09.01.610663 — microbiology — Posted on 2025-06-10
939 Extracting Reproducible Components from Electroencephalographic Responses to Transcranial Magnetic Stimulation with Group Task-Related Component Analysis
Couto, B. A. N.; Fecchio, M.; Russo, S.; De Martino, E.; Parmigiani, S.; Sarasso, S.; Graven-Nielsen, T.; de Andrade, D. C.; Massimini, M.; Rosanova, M.; Casali, A. G.
10.1101/2025.06.02.657489 — neuroscience — Posted on 2025-06-10
944 Rapid transcriptional response to a dynamic morphogen by time integration
Brantley, S. E.; Janssen, J.; Chao, A.; Vergassola, M.; Blythe, S. A.; Di Talia, S.
10.1101/2025.06.09.658715 — developmental biology — Posted on 2025-06-09
947 Convergent and divergent brain-cognition relationships during development revealed by cross-sectional and longitudinal analyses in the ABCD Study
Xie, Y.; Zhang, S.; Orban, C.; Ooi, L. Q. R.; Kong, R.; Floris, D. L.; Zuo, X.-N.; Dhamala, E.; Holmes, A. J.; Uddin, L. Q.; Nichols, T. E.; Di Martino, A.; Yeo, B. T. T.
10.1101/2025.06.06.658294 — neuroscience — Posted on 2025-06-09
955 AAV gene therapy for Cockayne syndrome
Batista, A. R.; Scholand, A. C.; Callahan, W. S.; Watson, M. K.; Sion, C. M.; Mola, T.; O'Hara, K.; King, O. D.; King, R. M.; Sena-Esteves, M.
10.1101/2025.06.06.658349 — neuroscience — Posted on 2025-06-09
956 The Vitis vinifera receptor VvLYK6 negatively regulates chitin-triggered immune responses and promotes fungal infections
VILLETTE, J.; MARZARI, T.; LANDRY, D.; ROUDAIRE, T.; ROMANET, R.; KLINGUER, A.; LEBORGNE-CASTEL, N.; VICEDO, C.; GASCIOLLI, V.; POUZET, C.; LEFEBVRE, B.; HELOIR, M. C.; POINSSOT, B.
10.1101/2025.06.06.658283 — plant biology — Posted on 2025-06-09
965 Monitoring for fisheries or for fish? Declines in monitoring of salmon spawners continue despite a conservation crisis
Atkinson, E. M.; Carturan, B. S.; Atkinson, C. P.; Bateman, A. W.; Connors, K.; Hertz, E.; Peacock, S. J.
10.1101/2024.12.01.626233 — ecology — Posted on 2025-06-09
969 Formins and Arp2/3 Reciprocally Regulate Contact Guidance on Aligned Collagen Fibrils
Foroozandehfar, A.; Tohidi, S.; Siddiqui, S. A.; Namanda, F. R.; Forrester, M.; Cochran, E.; Schneider, I.
10.1101/2025.01.03.631234 — bioengineering — Posted on 2025-06-09
970 A Slc5a6 Deficient Mouse Model Reveals a Metabolically Driven Dilated Cardiomyopathy with Therapeutic Potential for Vitamin-Based Intervention
Fullerton, M. O.; Phillips, L. C.; Redgrave, R. E.; Haufroid, V.; Merces, G.; Kerridge, S. T.; Richardson, G. D.; Mercier, N.; Roland, D.; Dewulf, J. P.; Burn, J.; Bamforth, S. D.; Phillips, H. M.
10.1101/2025.06.06.658273 — genetics — Posted on 2025-06-09
972 Chromosome-length genome assembly of Uta stansburiana and gene expression data reveal fast pace-of-life comes with environmental stability
Fellows, S.; Araya-Donoso, R.; Davalos-Dehullu, E.; Khan, R.; Weisz, D.; Dudchenko, O.; Aiden, E. L.; Munguia-Vega, A.; Dolby, G. A.; Edwards, D. L.
10.1101/2025.05.28.656178 — evolutionary biology — Posted on 2025-06-09
973 Caudata macrogenetics: Geographic attributes predict mitochondrial genetic variation in salamanders on a global scale
Amador, L.; Wiley, D. L. F.; Arroyo-Torres, I.; McDaniels, C. X.; Rosario-Sanchez, E. O.; Farmer, H.; Bradley, H.; Erdmann, J.; Pelletier, T. A.; Barrow, L. N.
10.1101/2025.01.24.634750 — evolutionary biology — Posted on 2025-06-09
975 Metacaspases mediate thermotolerance of diatoms following marine heat waves
Sadeh, M.; Schatz, D.; Ben-Dor, S.; Mizrachi, A.; Graff van Creveld, S.; Zafrin, A.; Vardi, A.
10.1101/2025.06.09.658587 — microbiology — Posted on 2025-06-09
976 Analysis of Essential Genes in Clostridioides difficile by CRISPRi and Tn-seq
Alberts, M. E.; Kurtz, M. P.; Müh, U.; Bernardi, J. P.; Bollinger, K. W.; Duncan, L.; Dobrila, H. A.; Laster, H. M.; Orea, A. J.; Pannullo, A. G.; Rivera-Rosado, J. G.; Torres, F. V.; Ellermeier, C. D.; Weiss, D. S.
10.1101/2025.06.04.657922 — microbiology — Posted on 2025-06-09
977 Zα domain-dependent ZBP1 condensate formation induces an amyloidal necroptotic signalling complex
Nemegeer, J.; Soenmez, A.; Dierick, E.; Staes, K.; Naesens, L.; Vandenabeele, P.; Lafontaine, D. L.; Maelfait, J.
10.1101/2025.06.06.658343 — immunology — Posted on 2025-06-09
979 Enteric nervous system degeneration in human and murine CLN3 disease, is ameliorated by gene therapy in mice
Ziolkowska, E. A.; Williams, L. L.; Jansen, M. J.; Wang, S. H.; Eultgen, E. M.; Sharma, J.; Sardiello, M.; Bradley, R. P.; Whiteman, I. T.; Sands, M. S.; Heuckeroth, R. O.; Cooper, J. D.
10.1101/2025.01.29.635518 — neuroscience — Posted on 2025-06-09
980 Endothelin B receptor inhibition rescues aging-dependent neuronal regenerative decline
Feng, R.; Rosen, S. F.; Ansari, I.; John, S.; Thomsen, M. B.; Avraham, O.; Geoffroy, C. G.; Cavalli, V.
10.1101/2024.06.08.597928 — neuroscience — Posted on 2025-06-09
983 Single Cell Spatial Profiling Identifies Region-Specific Extracellular Matrix Adhesion and Signaling Networks in Glioblastoma
De, A.; Forero, S. A.; Pirani, A.; Morales, J. E.; De La Fuente-Granada, M.; Sebastian, S.; Huse, J. T.; Ballester, L. Y.; Weinberg, J. S.; Lang, F. F.; Akdemir, K. C.; McCarty, J. H.
10.1101/2024.10.31.621280 — cancer biology — Posted on 2025-06-09
986 Bacterial extracellular vesicles as a tunable platform for vaginal drug delivery
Steinman, D.; Hemanth, V.; McIlvaine, R.; Tyagi, P.; Kang, H.; Alam, R.; Liu, A.; Jewell, C.; Burd, I.; Molinari, S.; Zierden, H.
10.1101/2025.06.09.658669 — bioengineering — Posted on 2025-06-09
987 CalciumInsights: An Open-Source, Tissue-Agnostic Graphical Interface for High-Quality Analysis of Calcium Signals
Gomez, D. S.; Rosas, N. C. P.; Contreras, G. I. M.; Brana, S. R. C.; Zhang, W.; Mim, M. S.; Tan, S. G.; Gazzo, D.; Tepole, A. B.; Deng, Q.; Reeves, G. T.; Isaza, C. E.; Staiger, C. J.; Umulis, D. M.; Zartman, J. J.; Rios, M. C.
10.1101/2025.06.04.657923 — bioengineering — Posted on 2025-06-09
991 Loss of nephronophthisis-associated nephrocystin-1 impairs DNA damage repair in kidney organoids
Sendino Garvi, E.; Biermans, S.; Knoers, N. N. V. A. M.; van Eerde, A. A. M.; Masereeuw, R.; Slaats, G. G. G.; van Genderen, A. M.; Janssen, M. J.
10.1101/2025.06.09.658557 — molecular biology — Posted on 2025-06-09
992 DDX3X acts as a selective dual switch regulator of mRNA translation in acute ER stress
Shawky, A.-E.-M. A.; Scarboro, A.; Mick, J.; Dondeti, M.; Avanzino, K.; Simintiras, C.; Hatzoglou, M.; Vourekas, A.
10.1101/2025.06.08.658532 — molecular biology — Posted on 2025-06-09
993 Acute induction of IFNα is responsible for the attenuation of the live measles vaccine
Edwards, J.; Yoon, S.; Brockhurst, J. K.; Rennick, L. J.; Duprex, W. P.; Coppens, I.; Pekosz, A.; Griffin, D. E.
10.1101/2025.06.09.658652 — microbiology — Posted on 2025-06-09
996 Prenatal Zika Virus Exposure Disrupts Social-Emotional Development and Cortical Visual Function in Infant Macaques
Ausderau, K. K.; Boerigter, B.; Razo, E. R.; Gutkes, J.; Krabbe, N. P.; Mitzey, A. M.; Walsh, S.; Menna, V.; Drew, J. R.; Kabakov, S.; Eckes, F.; Spanton, R. V.; Shah, A.; Sun, A.; Katz, A.; Kim, C.; Hartman, A.; Weiler, A. M.; Rasmussen, C.; Nork, M.; Basu, P.; Simmons, H. A.; Ver Hoeve, J.; Capuano, S.; Friedrich, T. C.; Mohr, E. L.
10.1101/2025.06.09.658678 — microbiology — Posted on 2025-06-09
998 Plasticity in a bacterial global regulatory switch that drives a shift in antibiotic resistance and virulence
Correia, A.; Manners, E. J.; Evans, B. A.; Malone, J. G.; O'Grady, J.; Mavrogiorgou, E.; Arminu, S.; Usai, M.; Naik, D.; McMillan, S.; Kay, G. L.; Hill, C.; Sudhakar, P.; Meader, E.; Schmidt, K.; Korcsmaros, T.; Desbois, A. P.; Crossman, L.; Wain, J.; Langridge, G. C.
10.1101/2025.06.09.658697 — microbiology — Posted on 2025-06-09
1001 Identification of reactive CpGs and RNA expression in early COVID-19 through cis-eQTM analysis reflecting disease severity and recovery
Ryu, H.; An, K.; Kwon, Y.; Jeon, Y.; Jeon, S.; Choi, H.; Kim, Y. J.; Kim, S.; Sul, O. J.; Lee, S.; Chun, A. Y.; Shin, E.-S.; Ra, S. W.; Bhak, J.
10.1101/2025.06.09.658549 — bioinformatics — Posted on 2025-06-09
1002 High-throughput in vivo screening using barcoded mRNA identifies lipid nanoparticles with extrahepatic tropism for cancer immunotherapy
Hamilton, A. G.; Thatte, A. S.; Xu, J.; Luo, Z.; Safford, H. C.; Swingle, K. L.; Muscat-Rivera, J.; Kegel, M.; Han, X.; Joseph, R. A.; Murray, A. M.; Geisler, H. C.; Whitaker, R. C.; Xue, L.; Spektor, R.; Melamed, J. R.; Weissman, D.; Mitchell, M. J.
10.1101/2025.06.09.658602 — bioengineering — Posted on 2025-06-09
1003 Expression of a human Gb3/CD77 synthase in insect and human cells: comparison of activity and glycosylation
Mikolajczyk, K.; Szymczak-Kulus, K.; Bereznicka, A.; Kaczmarek, R.; Sobala, L. F.; Jakubiak-Augustyn, A.; Czerwinski, M.
10.1101/2025.06.09.658241 — biochemistry — Posted on 2025-06-09
1005 Methane-fed microbial communities enriched from field-grown rice support diverse heterotrophic bacteria
Perry, E. K.; Hasnain, A.; Cole, B. J.; Carlson, H. K.; Deutschbauer, A. M.; Chiniquy, D.
10.1101/2025.06.09.658666 — microbiology — Posted on 2025-06-09
1006 Brain FGF2 and NCAM1 contribute to FGFR1-dependent progression of ER+ breast cancer brain metastases in young and aged hosts
Fox, M. S.; Jaramillo-Gomez, J. A.; Marquez-Ortiz, R. A.; Alvarez-Eraso, K. L. F.; Contreras Zarate, M. J.; Koliavas, S.; Kabos, P.; Serkova, N. J.; Sartorius, C. A.; Wellberg, E. A.; Cittelly, D. M.
10.1101/2025.06.07.658373 — cancer biology — Posted on 2025-06-09
1007 Inflammasome activation differences underpin different Mycobacterium tuberculosis infection outcomes
Kumar, R.; Kolloli, A.; Bhargavi, G.; Husain, S.; Ghanny, S.; Soteropoulos, P.; Subbian, S.
10.1101/2025.06.06.658135 — immunology — Posted on 2025-06-09
1009 Improved Allele Frequencies in gnomAD through Local Ancestry Inference
Kore, P.; Wilson, M.; Tiao, G.; Chao, K. R.; Darnowsky, P. W.; Watts, N.; Honorato-Mauer, J.; Baxter, S. M.; Genome Aggregation Database Consortium, ; Rehm, H.; Daly, M.; Karczewski, K. J.; Atkinson, E. G.
10.1101/2024.10.30.620961 — genomics — Posted on 2025-06-09
1010 Failed Cellular Surveillance Enables Pathogenic Matrix Deposition in a COL2A1-Related Osteoarthritis
Yammine, K. M.; Abularach, S. M.; Kim, S.-y.; Bikovtseva, A. A.; Lilianty, J.; Butty, V. L.; Schiavoni, R. P.; Bateman, J. F.; Lamande, S. R.; Shoulders, M. D.
10.1101/2023.10.19.562780 — genetics — Posted on 2025-06-09
1012 Single-cell and cell-type-level insights into stress-driven immune regulation relevant to disease
Benavides, S.; Kosyk, O.; Carpenter, L.; Georgiou, C.; Miller, B. C.; Stanley, N.; Zannas, A. S.
10.1101/2025.06.05.658150 — immunology — Posted on 2025-06-09
1013 Imaging CRISPR-Edited CAR-T Cell Therapies with Optical and Positron Emission Tomography Reporters
Sanchez-Pupo, R. E.; Kelly, J. J.; Shalaby, N.; Xia, Y.; Martinez Santiesteban, F. M.; Lau, J.; Verriet, I.; Hicks, J.; Fox, M.; Thiessen, J. D.; Ronald, J. A.
10.1101/2025.06.06.658308 — immunology — Posted on 2025-06-09
1014 SINE compounds activate exportin-1 degradation via an allosteric mechanism
Wing, C. E.; Fung, H. Y. J.; Kwanten, B.; Cagatay, T.; Niesman, A. B.; Jacquemyn, M.; Gharghabi, M.; Permentier, B.; Shakya, B.; Nandi, R.; Ready, J. M.; Kashyap, T.; Shacham, S.; Landesman, Y.; Lapalombella, R.; Daelemans, D.; Chook, Y. M.
10.1101/2024.10.07.617049 — cancer biology — Posted on 2025-06-09
1016 ArchMap: A web-based platform for reference-based analysis of single-cell datasets
Lotfollahi, M.; Bright, C.; Skorobogat, R.; Dehkordi, M.; George, X.; Richter, S.; Topalova, A.; Shitov, V.; Luecken, M. D.; Theis, F. J.
10.1101/2024.09.19.613883 — bioinformatics — Posted on 2025-06-09
1017 A hybrid machine learning framework leveraging biophysicochemical insights for scalable discovery of protein-ligand interactions
Rayakar, A. A.; Jaladanki, C. K.; Ong, Q.; Tan, B.; Chen, J.; Tan, A. Q. L.; Lim, L. T. R.; Kohaal, N.; Chen, Y.; Wang, J.; Han, W.; Hu, J.; Lee, H. K.; Fan, H.
10.1101/2025.03.16.643501 — bioinformatics — Posted on 2025-06-09
1018 Brain-derived extracellular vesicle microRNAs in Lewy body and Alzheimer's disease
Yang, S. J.; Lin, A. A.; Shen, H.; Pappalardo, L. W.; Spychalski, G. B.; Rosario, J.; Forsberg, L. K.; Grant, K. M.; Savica, R.; O'Bryant, S.; Jones, D. T.; Dickson, D. W.; Reichard, R. R.; Nguyen, A. T.; Meaney, D. F.; Boeve, B. F.; Ross, O. A.; McLean, P. J.; Issadore, D.
10.1101/2025.06.06.656900 — bioengineering — Posted on 2025-06-09
1019 Low-density lipoprotein receptor-targeting chimeras for membrane protein degradation and enhanced drug delivery
Zhao, F.; Wu, Y.; Schaefer, K.; Zhang, Y.; Miao, K.; Yao, Z.; Ganjave, S. D.; Kumru, K.; Peters-Clarke, T. M.; Inague, A.; Olzmann, J. A.; Leung, K. K.; Wells, J. A.
10.1101/2025.06.06.658366 — bioengineering — Posted on 2025-06-09
1020 Combined Central and Peripheral Nerve Stimulation Improves Functional Recovery of Mixed Peripheral Nerve Injury in a Rat Forelimb Model
Eftekari, S. C.; Yoon, Y.-C.; Chen, R. C.-H.; Nicksic, P. J.; Donnelly, D. T.; Jesch, A.; Shaffrey, E. C.; Zeng, W.; Ludwig, K. A.; Poore, S. O.; Vakoc, B. J.; Suminski, A.; Dingle, A. M.
10.1101/2025.01.26.634922 — neuroscience — Posted on 2025-06-09
1023 MIRO1 controls energy production and proliferation of vascular smooth muscle cells
Qian, L.; Koval, O. M.; Endoni, B. T.; Juhr, D.; Stein, C. C.; Allamargot, C.; Lin, L.-H.; Guo, D.-F.; Rahmouni, K.; Boudreau, R. L.; Streeter, J.; Thiel, W. H.; Grumbach, I. M.
10.1101/2024.08.13.607854 — cell biology — Posted on 2025-06-09
1025 Single-cell and cell-type-level insights into stress-driven immune regulation relevant to disease
Benavides, S.; Kosyk, O.; Carpenter, L.; Georgiou, C.; Miller, B. C.; Stanley, N.; Zannas, A. S.
10.1101/2025.06.05.658150 — immunology — Posted on 2025-06-09
1026 Effects of diffusion MRI spatial resolution on human brain short-range association fiber reconstruction and structural connectivity estimation
Zheng, J.; Li, Z.; Zhong, W.; Wang, Z.; Li, Z.; Yang, H.; Liu, M.; Cao, X.; Liao, C.; David, S. H.; Huang, S. Y.; Tian, Q.
10.1101/2025.06.04.657810 — neuroscience — Posted on 2025-06-09
1027 Too little and too much: balanced hippocampal, but not medial prefrontal, neural activity is required for intact novel object recognition in rats
Taylor, C. J. L.; Renstrom, J. G.; Loayza, J.; Gwilt, M.; Williams, S. A.; Grasmeder Allen, R.; Moran, P. M.; Gigg, J.; Neill, J.; Harte, M.; Bast, T.
10.1101/2025.04.01.646403 — neuroscience — Posted on 2025-06-09
1031 Testing for a wildlife reservoir of divergent SARS-CoV-2 in white-tailed deer
Crawshaw, L.; Kotwa, J. D.; Jeeves, S. P.; Loomer, C.; Dibernardo, A.; Stewart, A.; Newar, S. L.; Chien, E.; Yim, W.; Kruczkiewicz, P.; Vernygora, O.; Lung, O.; Schulte-Hostedde, A. I.; Nituch, L.; Maguire, F.; Pickering, B.; Jardine, C. M.; Coatsworth, H.; Mubareka, S.; Bowman, J.
10.1101/2025.05.22.655348 — pathology — Posted on 2025-06-09
1032 Infrared Laser Sampling of Low Volumes Reveals Marker Lipids in Palatine Tonsil Carcinoma via Shotgun Lipidomics
Kerkhoff, L.; Moritz, M.; Eggert, D.; Worthmann, A.; Heeren, J.; Zech, H.; Clauditz, T.; Wilczak, W.; Schlueter, H.; Betz, C. S.; Bottcher, A.; Hahn, J.
10.1101/2025.06.05.658016 — cancer biology — Posted on 2025-06-09
1033 PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer
Young, A. A.; Juhler, I. G.; Pierce, J. R.; Bohlin, H. E.; Harper, H. A.; Onishile, D. S.; Chua, R. N.; Liu, M. E.; Gardner, E. N.; Elzey, B. D.; Cottrell, K. A.
10.1101/2025.05.27.656288 — cancer biology — Posted on 2025-06-09
1034 GTP cycling gates CTP synthase activation
Guo, C.-J.; Wu, Y.-F.; Guo, S.-Y.; Lu, J.-L.; Xu, L.; Fu, Y.; Zhou, X.; Zhong, J.; Wang, W.; Zhang, Z.; Liu, J.-L.
10.1101/2022.09.24.509316 — biochemistry — Posted on 2025-06-09
1035 A Cryptic Interfacial Pocket Uncovered in Full CRL4CRBN-IKZF3 Ubiquitylation Complex Enhances IMiD Efficacy
Deng, Z.; Ai, H.; Shi, Q.; Liang, J.; He, Z.; Zheng, J.; Li, H.; Zhang, L.; He, W.; Tao, S.; Zheng, Q.; He, W.; Pan, M.; Liu, L.
10.1101/2025.06.08.658527 — biochemistry — Posted on 2025-06-09
1037 Hb-EGF directs systemic muscle repair
Dean, H. C.; Saraswathy, V.; Saini, A.; Ou, T.; McAdow, J.; Tendolkar, A.; Mokalled, M.; Johnson, A. N.
10.1101/2025.06.04.657846 — developmental biology — Posted on 2025-06-09
1038 Remodelled cholesteryl ester enriched lipid droplets fuel flavivirus morphogenesis
Banducci-Karp, A.; Brixton, S.; Shah, P. M.; Li, M.-Y.; Bancroft, J.; Riepsaame, J.; Dhaliwal, R.; Melia, C. E.; Malavige, G. N.; Sanyal, S.
10.1101/2025.06.07.658178 — cell biology — Posted on 2025-06-09
1039 A Transient Increase in Cardiomyocyte Protein O-GlcNAcylation Enhances Susceptibility to Pressure Overload-Induced Cardiac Remodeling
Chang, S. F.; Ha, C.-M.; Brahma, M. K.; Potter, L. A.; Reddy, M. S.; Bakshi, S.; Preuss, K.; Rahman, M. S.; Fischer, J.; Harrell, C. A.; Sun, Z.; Chatham, J. C.; Wende, A. R.
10.1101/2025.06.04.657956 — molecular biology — Posted on 2025-06-09
1040 Accumulation of LRRK2-associated phospho-Rab12 degenerative lysosomes in tauopathies
Buck, S. A.; Malankhanova, T.; Ma, E. B.; Yim, S.; Pratt, H. W.; Ervin, J.; Wang, S.-H. J.; Cohen, T. J.; West, A. B.; Sanders, L. H.
10.1101/2025.06.06.658328 — neuroscience — Posted on 2025-06-09
1041 Smelling the Risk: Early Olfactory Deficits, Brain Networks, and Blood Markers of Alzheimers Disease Risk in Humanized APOE Mice
Moon, H. S.; Han, Z. Y.; Anderson, R. J.; Mahzarnia, A.; Stout, J. A.; Niculescu, A.; Tremblay, J.; Badea, A.
10.1101/2025.06.06.658383 — neuroscience — Posted on 2025-06-09
1043 Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of Fragile X syndrome.
Wang, H.-B.; Smale, N. E.; Brown, S. H.; Villanueva, S. A.; Zhou, D.; Mulji, A.; Bhandal, D. S.; Nguyen-Ngo, K.; Harvey, J. R.; Ghiani, C. A.; Colwell, C. S.
10.1101/2024.09.16.613343 — neuroscience — Posted on 2025-06-09
1045 A Chromosome-Level Assembly of the Pine Processionary Moth (Thaumetopoea pityocampa) genome
Gautier, M.; Nouhaud, P.; Lagnel, J.; Saune, L.; Legeai, F.; Parinello, H.; Gschloessl, B.; Marande, W.; Lopez-Roques, C.; Dorkeld, F.; Branco, M.; Perrier, C.; Kerdelhue, C.
10.1101/2025.06.06.658235 — genomics — Posted on 2025-06-09
1046 Multiparent Recombinant Inbred lines crossed to a tester provide novel insights into sources of cis and trans regulation of gene expression
Marroni, F.; Morse, A. M.; Nanni, A.; Nolte, N. F.; Williams-Simon, P.; Leon-Novelo, L. G.; Graze, R. M.; Schmidt, P.; King, E. G.; McIntyre, L. M.
10.1101/2025.06.07.658407 — genetics — Posted on 2025-06-09
1048 Uncovering Heterogeneous Effects via Localized Feature Selection
Liu, X.; Gu, J.; Chen, Z.; Chu, B.; Liu, L.; Morrison, T.; Butler, R. R.; Edelson, J.; Li, J.; Longo, F. M.; Tang, H.; Ionita-laza, I.; Sabatti, C.; Candes, E.; He, Z.
10.1101/2025.06.03.657761 — bioinformatics — Posted on 2025-06-09
1051 Localization of KANK2 to Focal or Fibrillar Adhesions Influences Migration in Melanoma Cell Lines
Stojanovic, N.; Rac, A.; Loncaric, M.; Tadijan, A.; Paradzik, M.; Acman, M.; Humphries, J. D.; Humphries, M. J.; Ambriovic-Ristov, A.
10.1101/2025.02.24.639831 — cell biology — Posted on 2025-06-09
1052 TURBO: Automated Total-body PET Image Processing and Kinetic Modeling Toolbox
Tuisku, J.; Palonen, S.; Kärpijoki, H.; Latva-Rasku, A.; Tuomola, N.; Harju, H.; Nesterov, S.; Oikonen, V.; Iida, H.; Teuho, J.; Han, C.; Karjalainen, T.; Kirjavainen, A. K.; Rajander, J.; Klen, R.; Nuutila, P.; Nummenmaa, L.; Knuuti, J.
10.1101/2025.06.06.658206 — neuroscience — Posted on 2025-06-09
1054 Identification and Validation of a Previously Missed Mutational Signature in Colorectal Cancer
Kazachkova, M.; Otlu-Saritas, B.; Diaz-Gay, M.; Abbasi, A.; Moody, S.; Perdomo, S.; Wedge, D. C.; Brennan, P.; Stratton, M.; Alexandrov, L. B.
10.1101/2025.06.06.658321 — cancer biology — Posted on 2025-06-09
1058 Forecasting oncogene amplification and tumour suppressor deletion
Hernando, B.; Fernandez-Sanroman, A.; Cadiz, A.; Santamaria, P. G.; Gomez-Sanchez, D.; Escobar-Rey, M.; Chaves-Urbano, B.; Thompson, J. S.; Torres, M.; Ruiz de Garibay, G.; Adradas, V.; Alvarez, E.; The Pan Prostate Cancer Group, ; Tarabichi, M.; Lesluyes, T.; Coya, J. M.; Zugazagoitia, J.; Paz-Ares, L.; Macintyre, G.
10.1101/2025.06.06.658212 — genomics — Posted on 2025-06-09
1059 Persistent ECM Scarring Reprograms Intestinal Stem Cells to Drive Chronic Inflammation
Adir, I.; Sochen, C.; Menachem, A. H.; Lebon, S.; Toval, B.; Holiar, V.; Davidzohn, N.; Salame, T. M.; Rosenhek-Goldian, I.; Savickas, S.; Sabino, F.; auf dem Keller, U.; Biton, M.; Sagi, I.
10.1101/2025.06.08.658481 — immunology — Posted on 2025-06-09
1060 TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950
Lackner, A.; Leonidas, L.; Macapagal, A.; Lee, H.; Xu, H.; Qiu, Y.; Campos, M.; Cabral, J. E.; Onyuru, J.; Kulkarni, S.; Albrecht, L.; Hoffman, H. M.; McNulty, R.
10.1101/2025.06.05.658156 — immunology — Posted on 2025-06-09
1061 Structural insights into wiring specificity in the neuromuscular system through the Beat-Side complex
Priest, J. M.; Zhang, R.; Olechwier, A. M.; Caspi-Lebovic, A. B.; Ashley, J.; Aher, V.; Carrillo, R. A.; Özkan, E.
10.1101/2025.06.05.656487 — neuroscience — Posted on 2025-06-09
1063 Multivariate Resting-State Functional Connectivity Features Linked to Transdiagnostic Psychopathology in Early Psychosis
Wang, H. R.; Liu, Z.-Q.; Nomi, J. S.; Schleifer, C. H.; Bearden, C. E.; Misic, B.; Uddin, L. Q.; Karlsgodt, K. K.
10.1101/2025.06.04.654984 — neuroscience — Posted on 2025-06-09
1065 Neurological effects induced by micro- and nanoplastics in fish: a systematic review and meta-analysis
Klippel Zanona, Q.; Gallas-Lopes, M.; Alves Marconi, G.; Nachtigall Lazzarotto, I.; Piato, A.; Herrmann, A. P.; Calcagnotto, M. E.
10.1101/2025.06.07.658168 — neuroscience — Posted on 2025-06-09
1066 Development of a Novel Benzodiazepine to Delineate Peripheral GABA-A Signaling Mechanisms in Visceral Pain Syndromes
Poslusney, M. S.; Li, Q.; Buchler, I. P.; Huang, Y.; Liu, L.; Zhu, Y.; Kulkarni, S.; Carr, G.; DeBrosse, A.; White, N.; Peters, D.; Barrow, J. C.; Pasricha, P. J.
10.1101/2025.06.08.658501 — neuroscience — Posted on 2025-06-09
1068 Intra-subtype heterogeneity shapes treatment response in KMT2A-rearranged ALL across all age groups
Hartmann, A. M.; Bastian, L.; Barz, M. J.; Haas, J.; Amelunxen, E.; Ehm, P.; Lenk, L.; Kotrova, M.; Beder, T.; Steffen, F.; Rauwolf, K.; Wolgast, N.; Bendig, S.; Bozzetti, C.; Alten, J.; Mondal, M.; Rademacher, A.; Heymann, J.; Walter, W.; Haferlach, C.; Ströh, A.-S.; Bergmann, A. K.; Burmeister, T.; Gökbuget, N.; Bornhauser, B.; Bourquin, J.-P.; Brüggemann, M.; Schrappe, M.; Cario, G.; Baldus, C. D.
10.1101/2025.06.05.657589 — cancer biology — Posted on 2025-06-09
1069 A high-throughput immunopeptidome platform for MHC II alleles to characterize antigen-specific CD4 + T cells
Chen, J.; Zhu, X.; Huo, J.; Wu, S.; Zhou, T.; Cheng, C.; Dong, H.; Li, Y.; Chen, Y.; Dong, X.
10.1101/2025.06.05.658000 — biochemistry — Posted on 2025-06-09
1070 De novo genome assembly of Ansell's mole-rat (Fukomys anselli)
Bekavac, M.; Coimbra, R.; Busa, V. F.; Behm, M.; Wagner, R. E.; Goncalves, A.; Begall, S.; Frye, M.; Odom, D. T.
10.1101/2025.06.03.657636 — genomics — Posted on 2025-06-09
1071 A pan-generic marker panel for apples to enable genetic research and breeding across Malus species
Sakina, A.; Tegtmeier, R.; Feulner, H.; Hickok, D.; Svara, A.; Cho, P.; Clark, M.; Kilian, A.; Glaubitz, J.; Sun, Q.; Khan, A.
10.1101/2025.06.05.657940 — genetics — Posted on 2025-06-09
1074 Duration of immunity following infection with moderately virulent ASFV
Friedrichs, V.; Deutschmann, P.; Wernike, K.; Carrau, T.; Beer, M.; Blome, S.; Schäfer, A.
10.1101/2025.06.05.657993 — immunology — Posted on 2025-06-09
1075 CFTR mutation leads to intrinsic dysfunction in neutrophils from people with Cystic Fibrosis
Robledo-Avila, F. H.; Rascon, R.; Montanez-Barragan, A.; Loyo-Celis, V.; Singh, H.; McCoy, K. S.; Kopp, B. T.; Partida-Sanchez, S.
10.1101/2025.06.08.656500 — immunology — Posted on 2025-06-09
1076 Interlinked roles for HEB and Id3 in fetal gamma-delta T cell commitment and functional programming
Selvaratnam, J. S.; Barbosa da Rocha, J. D.; Rajan, V.; Wang, H.; Reddy, E. C.; Gams, M. S.; Murre, C.; Guidos, C. J.; Zuniga-Pflucker, J. C.; Anderson, M. K.
10.1101/2025.06.08.658490 — immunology — Posted on 2025-06-09
1077 Ambient Pollution Components and Sources Associated with Hippocampal Architecture and Memory in Pre-Adolescents
Rosario, M. A.; Sukumaran, K.; Bottenhorn, K. L.; de Jesus, A.; Cardenas-Iniguez, C.; Ahmadi, H.; Habre, R.; Abad, S.; Pine, J. G.; Barch, D. M.; Schwartz, J.; Hackman, D. A.; Chen, J.-C.; Herting, M. M.
10.1101/2025.06.05.658105 — neuroscience — Posted on 2025-06-09
1079 Youth-associated protein TIMP2 alters microglial state and function in the context of aging
Hemmer, B. M.; Ferreira, A. C.; Philippi, S. M.; Petridis, S. F.; Phan, A.; Castellano, J. M.
10.1101/2025.05.20.655226 — neuroscience — Posted on 2025-06-09
1082 In vivo RUBISCO activity in Synechocystis is regulated by RuBP availability
Wittemeier, L.; Arrivault, S.; Neumann, N.; Macek, B.; Schmidt, N.; Hagemann, M.; Kopka, J.
10.1101/2025.06.06.658252 — plant biology — Posted on 2025-06-09
1083 Calorie restriction suppresses aging alpha cell pro-inflammatory signaling
Schleh, M.; Cambraia, A.; Cutler, M.; Ferguson, G.; Arrojo e Drigo, R.
10.1101/2025.06.04.657914 — physiology — Posted on 2025-06-09
1084 Bacteria-induced colitis in naked mole rats is alleviated by probiotic treatment: a new mammalian model for acute inflammatory disease
Hart, D. W.; Ng, A. S.; Gazinska, P.; Goldin, R.; Gopal, P.; O'Dell, N.; Montazid, S.; East, J. E.; Tomlinson, I. P.; Koch, N.; Bennett, N. C.; Irshad, S.
10.1101/2025.06.05.658065 — pathology — Posted on 2025-06-09
1085 Observing intersubunit dynamics in single yeast ribosomes
Das, A.; Ivanov, A. V.; Wakabayashi, H.; Grove, A. K.; Ermolenko, D. N.
10.1101/2025.06.05.658109 — biophysics — Posted on 2025-06-09
1086 Membrane phosphoinositides allosterically tune β-arrestin dynamics to facilitate GPCR core engagement
Janetzko, J.; Deutsch, J.; Shi, Y.; Siepe, D. H.; Masureel, M.; Liu, W.; Viner, R.; Inoue, A.; Kobilka, B. K.; Shivnaraine, R. V.
10.1101/2025.06.06.658200 — biophysics — Posted on 2025-06-09
1087 A light-weight segmentation method for multi-state Brownian trajectories
El Korde, I.; Lewis, J. M.; Clarkson, E.; Dam, T.; Jönsson, P.; Ambjörnsson, T.; Stenhammar, J.
10.1101/2025.06.05.658053 — biophysics — Posted on 2025-06-09
1091 PLIERv2: bigger, better and faster
Subirana-Granes, M.; Nandi, S.; Zhang, H.; Chikina, M.; Pividori, M.
10.1101/2025.06.05.658122 — bioinformatics — Posted on 2025-06-09
1093 PIVOT: an open-source tool for multi-omic spatial data registration
Forjaz, A.; Romero, V. M.; Reucroft, I.; Eminizer, M.; Kramer, D.; Higuera, D.; Mojdeganlou, H.; Guerrero, P. A.; Min, J.; Wetzel, M.; Lvovs, D.; Valentin, A.; Shin, S. M.; Xuan, Y.; Sears, R. C.; Chin, K.; Maitra, A.; Fertig, E. J.; Ho, W. J.; Kagohara, L. T.; Wood, L. D.; Wirtz, D.; Sidiropoulos, D. N.; Kiemen, A. L.
10.1101/2025.06.08.658506 — bioinformatics — Posted on 2025-06-09
1097 A Tunable Pulmonary Organoid Model Demonstrates Compositionally Driven Epithelial Plasticity and Immune Polarization
Edelstein, S. E.; Mizoguchi, S.; Gracia, M. T.; Wang, N.; Lee, V.; Kim, H.; Haynes, C.; Danelski, C.; Tsuchiya, T.; Sauler, M.; Raredon, M. S. B.
10.1101/2025.06.05.658120 — bioengineering — Posted on 2025-06-09
1098 Mechanisms of KCNQ1 gating modulation by KCNE1/3 for cell-specific function
Cui, C.; Zhao, L.; Kermani, A. A.; Du, S.; Pipatpolkai, T.; Jiang, M.; Chittori, S.; Tan, Y.; Shi, J.; Delemotte, L.; Cui, J.; Sun, J.
10.1101/2025.06.08.658478 — biochemistry — Posted on 2025-06-09
1099 Unraveling the start element and regulatory divergence of core promoters across the domain Bacteria
Kuo, S.-T.; Chang, J. K.; Chang, C.; Shen, W.-Y.; Hsu, C.; Lai, S.-W.; Chou, H.-H. D.
10.1101/2025.01.23.634641 — genomics — Posted on 2025-06-09
1100 Impact of Sperm Fractionation on Chromosome Positioning, Chromatin Integrity, DNA Methylation and Hydroxymethylation Level
Graczyk, Z.; Kostyk, J.; Pospieszna, J. A.; Myslicka, Z.; Kamieniczna, M.; Fraczek, M.; Olszewska, M.; Kurpisz, M.
10.1101/2025.06.07.658443 — genetics — Posted on 2025-06-09
1102 Generation and characterization of a mouse model of conditional Chd4 knockout in the endometrial epithelium.
Chandler, R. L.; Harkins, S. K.; Skalski, H. J.; Bennett, A. Z.; Pavliscak, L.; Arendt, A. R.; Wood, L.; Moldovan, G. E.
10.1101/2025.06.05.658183 — developmental biology — Posted on 2025-06-09
1103 Primitive Hepatoblasts Driving Early Liver Development
Iwasawa, K.; Koike, H.; Reza, H. A.; Milton, Y.; Kishimoto, K.; Thorner, K.; Granitto, M.; Saiki, N.; Santangelo, C.; Glaser, K.; Kimura, M.; Bondoc, A.; Lim, H.-W.; Morimoto, M.; Iwafuchi, M.; Wells, J. M.; Zorn, A. M.; Takebe, T.
10.1101/2025.06.08.658502 — developmental biology — Posted on 2025-06-09
1104 Canonical nuclear envelope protein emerin regulates structure and integrity of the erythrocyte plasma membrane
O'Brien, B.; Oliver, J.; Thompson, E. N.; Mayday, M. Y.; Mancuso, R.; Jha, A.; Kwan, J.; Bonne, G.; Ben Yaou, R.; Leturcq, F.; Bai, S.; Nottoli, T.; Hwa, J.; Krause, D. S.; Gallagher, P. G.; Gu, S. X.; Martin, K. A.
10.1101/2025.06.06.658339 — cell biology — Posted on 2025-06-09
1105 Diminished and altered cellular senescence response in delayed wound healing of aging
Shvedova, M.; Thanapaul, R. J. R. S.; Wang, Q.; Shin, G. H.; Dhillon, J.; Roh, D. S.
10.1101/2025.06.08.658533 — cell biology — Posted on 2025-06-09
1107 Remodelled cholesteryl ester enriched lipid droplets fuel flavivirus morphogenesis
Banducci-Karp, A.; Brixton, S.; Shah, P. M.; Li, M.-Y.; Bancroft, J.; Riepsaame, J.; Dhaliwal, R.; Melia, C. E.; Malavige, G. N.; Sanyal, S.; Bancroft, J.
10.1101/2025.06.07.658178 — cell biology — Posted on 2025-06-09
1109 G1 and G2 ApolipoproteinL1 modulate macrophage inflammation and lipid accumulation through the polyamine pathway
Liu, E.; Wright, M.; Kearney, A. O.; Caza, T.; Yang, J. Y.; Garcia, V.; Dadi, A. O.; Ishibe, S.; Chandel, N. S.; Zhang, H.; Benjamin Thorp, E.; Lin, J.
10.1101/2025.06.06.658371 — cell biology — Posted on 2025-06-09
1110 The Anti-Inflammatory Role of GPNMB in Post-Traumatic Osteoarthritis
Al-Adlaan, A. A.; Cook, B.; Solorzano, E.; Hussein, N. J.; Jaber, F. J.; Kronk, T. A.; Frangiamore, S.; Ball, H. C.; Safadi, F. F.
10.1101/2025.06.06.658389 — cell biology — Posted on 2025-06-09
1111 Phosphoproteomics Maps Calcineurin-NFAT-DSCR1.4 Signaling as Druggable Axis in Gαq-R183Q-Driven Capillary Malformations
Xu, T.; Janssen, V.; Reinhard, N. R.; Sobrevals-Alcaraz, P.; van Es, R. M.; de Haan, A.; de Swart, J.; Wehrens, M.; Wolkerstorfer, A.; van der Horst, C. M. A. M.; Vos, H. R.; Huveneers, S.
10.1101/2025.06.07.658432 — cell biology — Posted on 2025-06-09
1112 Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections
Ngo, C.; Pierini-Malosse, C.; Rahmani, K.; Valente, M.; Collinet, N.; Bessou, G.; Guerry, C.; Fabregue, M.; Mathieu, S.; Sharkaoui, S.; Mazzoli, S.; Sansoni, A.; Fiore, F.; Laprie, C.; Alexopoulou, L.; GAYA, M.; Gregoire, C.; Broggi, A.; Wurbel, S.; Rua, R.; Haidar, N.; Milpied, P.; Escaliere, B.; Phong, T.; Fallet, M.; Chasson, L.; Tran, H.; Le Bert, M.; Malissen, B.; ZARUBICA, A.; DALOD, M.; Tomasello, E.
10.1101/2024.05.20.594961 — immunology — Posted on 2025-06-09
1113 Rational Design of Immunogenic Nanoparticles as a Platform for Enhanced Ovarian Cancer Immunotherapy in Mice
Tang, L.; Marwedel, B.; Dang, C.; Olewine, M.; Jun, M.; Naydenkov, P.; Medina, L. Y.; Gayoso, V.; Doan, N.; OLeary, S. L.; Schiavone, C.; Cave, J.; Howard, T.; Watt, J. D.; Dogra, P.; Serda, R. E.; Noureddine, A.
10.1101/2025.06.05.657862 — immunology — Posted on 2025-06-09
1114 Opposing responses of hippocampal theta oscillations to running and a forelimb-dominated sensorimotor behavior
Holguin, G.; Jorgensen, K.; Tapia, A.; Jordan, G. A.; Vishwanath, A.; Barnes, C. A.; Cowen, S. L.
10.1101/2025.06.08.658384 — neuroscience — Posted on 2025-06-09
1115 Error encoding in human speech motor cortex
Hou, X.; Iacobacci, C.; Card, N. S.; Wairagkar, M.; Singer-Clark, T.; Kunz, E. M.; Fan, C.; Kamdar, F.; Hahn, N.; Hochberg, L. R.; Henderson, J. M.; Willett, F. R.; Brandman, D. M.; Stavisky, S. D.
10.1101/2025.06.07.658426 — neuroscience — Posted on 2025-06-09
1116 A Radiomic Approach to Clinical MRI Refines the Thalamus-Cognition Link in Multiple Sclerosis
Buyukturkoglu, K.; Lu, L.; Davis, L.; Orellana, R. E.; White, C. C.; Sun, R.; Ozcelik, S.; Isenstein, N. M.; Onomichi, K. B.; Iqbal, R.; Zhao, B.; Stern, Y.; Zeydan, B.; Kantarci, O. H.; Riley, C. S.; De Jager, P. L.
10.1101/2025.06.05.657698 — neuroscience — Posted on 2025-06-09
1117 Whisker stimulation reinforces a resting-state network in the barrel cortex: nested oscillations and avalanches
Mariani, B.; Guevara, R.; Tambaro, M.; Maschietto, M.; Leparulo, A.; Vassanelli, S.; Suweis, S.
10.1101/2025.06.06.658305 — neuroscience — Posted on 2025-06-09
1122 Phytoene synthase modulates seed longevity via the action of β-carotene derived metabolites
Hazra, A.; Rao, S.; Zhou, X.; Christel, M. J.; Wrightstone, E.; Yang, Y.; Fish, T.; Thannhauser, T.; Liu, J.; Mazourek, M.; Li, L.
10.1101/2025.06.05.658166 — plant biology — Posted on 2025-06-09
1125 Structural Acrobatics of IAA7: Exercising Fuzzy Regions to Aid Auxin-Mediated Catalysis
Parra, J. O. F.; Ott, M.; Bathia, T.; Emenecker, R.; Wolff, M.; Thalhammer, A.; Matschi, S.; Villalobos, L. I. A. C.
10.1101/2025.06.08.657175 — biophysics — Posted on 2025-06-09
1126 Biological Processes as Exploratory Dynamics
Kondev, J.; Kirschner, M. W.; Garcia, H. G.; Salmon, G.; Phillips, R.
10.1101/2025.06.06.657857 — biophysics — Posted on 2025-06-09
1130 Formation of a μ-oxo nucleophile enables efficient hydrolysis by a trinuclear metal center in Family II inorganic pyrophosphatase
Maruoka, S.; Kametani, Y.; Magome, E.; Setoyama, H.; Kawamoto, M.; Horitani, M.; Teramoto, T.; Kakuta, Y.; Shiota, Y.; Yoshizawa, K.; Watanabe, K.
10.1101/2025.06.08.658471 — biophysics — Posted on 2025-06-09
1132 tidypopgen: Tidy Population Genetics in R
Carter, E. J.; Tysall, E. E.; Hodgson, J.; Manica, A.
10.1101/2025.06.06.658325 — bioinformatics — Posted on 2025-06-08
1134 Affordable plasmonic biosensing: democratizing SERS with scalable, field-compatible substrate fabrication
Arora, S.; Ginde, V.; Tanwar, S.; Chazli, M. E.; Bhatt, R.; Edelman, E.; Paria, D.; Barman, I.
10.1101/2025.06.05.658202 — bioengineering — Posted on 2025-06-09
1135 Scaffold-free cryopreservable cartilage grafts obtained from hiPSC-derived chondroprogenitor cells for airway reconstruction with growth adaptability
Hanaki, S.; Takao, T.; Fujisawa, Y.; Ota, T.; Osone, T.; Otake, S.; Iwai, R.; Deguchi, K.; Yamamoto, K.; Okuyama, H.; Takarada, T.
10.1101/2025.06.05.654989 — bioengineering — Posted on 2025-06-09
1136 PEG-Free Tunable Poly(2-Oxazoline) Lipids Modulate LNP Biodistribution and Expression In Vivo after Intramuscular Administration
Basham, C.; Haney, M.; Zhao, Y.; Lukyanov, K. A.; Kim, K.; Baysal, A.; Hutsell, H.; Kabanov, A. V.; Ramsey, J. D.
10.1101/2025.06.05.657891 — bioengineering — Posted on 2025-06-09
1137 A Cryptic Interfacial Pocket Uncovered in Full CRL4CRBN-IKZF3 Ubiquitylation Complex Enhances IMiD Efficacy
Deng, Z.; Ai, H.; Shi, Q.; Liang, J.; He, Z.; Zheng, J.; Li, H.; Zhang, L.; He, W.; Tao, S.; Zheng, Q.; He, W.; Pan, M.; Liu, L.
10.1101/2025.06.08.658527 — biochemistry — Posted on 2025-06-09
1139 Cell-specific RNA isoform remodeling in the aging mouse brain
Rehman, A.; Duffy, M.; Gresova, K.; Belair, C.; Yang, N.; Wang, L.; Lee, C. T.; Payea, M.; Malla, S.; Dar, S. A.; Sen, P.; Cookson, M. R.; Maragkakis, M.
10.1101/2025.06.05.658133 — genomics — Posted on 2025-06-08
1141 Rapid divergence of male and female mitochondrial genomes in a basal protobranch bivalve Yoldia hyperborea
Fedorov, D. A.; Bezmenova, A. V.; Ezhova, M. A.; Kolbasova, G. D.; Tzetlin, A. B.; Neretina, T. V.; Knorre, D. A.
10.1101/2025.06.07.658435 — evolutionary biology — Posted on 2025-06-08
1143 Ex ante analyses can predict natural enemy efficacy in biological control
Gutierrez, A. P.; Ponti, L.; Neuenschwander, P.; Yaninek, J. S.; Baumgärtner, J. U.; Herren, H. R.
10.1101/2025.06.06.658262 — ecology — Posted on 2025-06-08
1144 Predicting Ecosystem Resilience Using Multi-Agent Reinforcement Learning
Strannegard, C.; Palak, M.; Emgsner, N.; Stocco, A.; Antonelli, A.; Silvestro, D.
10.1101/2025.06.07.658424 — ecology — Posted on 2025-06-09
1149 Epigenetic Regulation of Chondrogenesis: JMJD3 and UTX as Key Targets for Gene-Modified Mesenchymal Stem Cell Therapy in Cartilage Tissue Engineering
Allas, L.; Aury-Landas, J.; Rochoux, Q.; Julien, A.; Lhuissier, E.; Lente, M.; Brochard, S.; Veyssiere, A.; Boumediene, K.; Bauge, C.
10.1101/2025.06.06.658259 — developmental biology — Posted on 2025-06-08
1150 Genetic modulation of mitochondrial NAD+ regeneration does not prevent dopaminergic neuron dysfunction caused by mitochondrial complex I impairment
D'Alessandro, K. B.; Zampese, E.; Blum, J. L. E.; Kuusik, B.; Palmiotti, A.; Davidson, S. M.; Reczek, C. R.; Surmeier, D. J.; Chandel, N. S.
10.1101/2025.06.07.658365 — cell biology — Posted on 2025-06-08
1153 Unheralded high MHC Class II polymorphism in the abundant Atlantic herring resolved by long-read sequencing
Jamsandekar, M.; Sangdehi, F. M.; Berg, F.; Criscitiello, M. F.; Davis, B. W.; Larsson, M.; Li, j.; Pettersson, M. E.; Andersson, L.
10.1101/2025.06.08.658498 — immunology — Posted on 2025-06-08
1155 Transcriptome-Proteome analysis of human naive and memory B cell subsets reveal isotype and subclass-specific phenotypes
Koers, J.; Hoogendijk, A. J.; Tol, S.; van Alphen, F.; Derksen, N.; van den Biggelaar, M.; Rispens, T.
10.1101/2025.06.05.657894 — immunology — Posted on 2025-06-08
1156 Long-Range Input to Cortical Microcircuits Shapes EEG-BOLD Correlation
Chien, V. S. C.; Jiricek, S.; Knoesche, T. R.; Hlinka, J.; Schmidt, H.
10.1101/2025.06.06.658058 — neuroscience — Posted on 2025-06-08
1157 Modality-Agnostic Decoding of Vision and Language from fMRI
Nikolaus, M.; Mozafari, M.; Berry, I.; Asher, N.; Reddy, L.; VanRullen, R.
10.1101/2025.06.08.658221 — neuroscience — Posted on 2025-06-08
1158 Infection-Specific Reprogramming of Microglia Reveals Distinct Virulence Pathways Linking Periodontal Pathogens to Alzheimer's Disease
Kaminska, M.; Dudzinska, N.; Klapper, A.; Geissler, S.; Taudte, N.; Greiser, S.; Potempa, J.; Cynis, H.; Mydel, P.
10.1101/2025.06.06.658266 — neuroscience — Posted on 2025-06-08
1159 Nociceptin receptor and ligand in Alzheimer's disease:Implications for psychiatric symptoms and circadianregulation
Vogelgsang, J.; Gregory, S.; Smith, G. W.; Abston, J.; Kuhn, M.; Pizzagalli, D. A.; Berretta, S.
10.1101/2025.06.04.657953 — neuroscience — Posted on 2025-06-08
1161 Magnetoelectric nanodiscs diminish motor deficits in a model of Parkinson's disease
Kim, Y. J.; De Comite, A.; Paniagua, E. V.; Selvaraji, S.; Frey, E.; Mondal, R.; Seethapathi, N.; Anikeeva, P.
10.1101/2025.06.04.657885 — neuroscience — Posted on 2025-06-08
1167 Vertical rooting caused by enhanced functional allele of qSOR1 improves rice yield under drought stress
Kawai, T.; Kitomi, Y.; Kuroda, R.; Nakata, R.; Iba, M.; Soma, F.; Teramoto, S.; Yamazaki, T.; Sugimoto, K.; Uga, Y.
10.1101/2025.06.07.658467 — plant biology — Posted on 2025-06-08
1168 Salicylic acid accumulation correlates with low anthocyanin production in Arabidopsis
Drs, M.; Iakovenko, O.; Orozco, J. S. H.; Trhlinova, P. B.; Markovice, V.; Zarsky, V.; Pecenkova, T.; Janda, M.
10.1101/2025.06.08.658514 — plant biology — Posted on 2025-06-08
1171 Evaluation of graphene oxide-mediated NET formation using HL-60-derived neutrophil-like cells
Fukuhara, K.; Obama, T.; Ohinata, H.; Takaki, T.; Kato, M.; Totsuka, Y.; Itabe, H.; Ohno, A.
10.1101/2025.06.06.658248 — pharmacology and toxicology — Posted on 2025-06-08
1176 Quantifying Protein-Protein Interaction with a Spatial Attention Kinetic Graph Neural Network
xu, y.; Xia, W.; Zhang, C.; Liu, X.; Ju, C.; Dai, X.; Xie, P.; Wang, Y.; Chen, G.; Zhang, J.
10.1101/2025.06.04.657832 — bioinformatics — Posted on 2025-06-08
1178 CalciumInsights: An Open-Source, Tissue-Agnostic Graphical Interface for High-Quality Analysis of Calcium Signals
Gomez, D. S.; Rosas, N. C. P.; Contreras, G. I. M.; Brana, S. R. C.; Zhang, W.; Mim, M. S.; Tan, S. G.; Gazzo, D.; Tepole, A. B.; Deng, Q.; Reeves, G. T.; Isaza, C. E.; Staiger, C. J.; Umulis, D. M.; Zartman, J. J.; Rios, M. C.
10.1101/2025.06.04.657923 — bioengineering — Posted on 2025-06-08
1183 High-altitude mountaineering induces adaptive gut microbiome shifts associated with dietary intake and performance markers
Karpecka-Gałka, E.; Zielinska, K.; Fraczek, B.; Łabaj, P.; Kosciołek, T.; Huminska-Lisowska, K.
10.1101/2025.06.06.658263 — genomics — Posted on 2025-06-08
1184 Unique molecular identifier-based single strand mitochondrial DNA sequencing for rare substitution mutations
Li, Z. E. S.; Dunn, R.; Caloren, L. C.; Ziada, A. S.; Chapman, H.; Gadawska, I.; Cote, H. C. F.
10.1101/2025.06.05.657263 — genomics — Posted on 2025-06-08
1185 Tracing genome size dynamics in sharks and rays with inclusive sequence analysis by the Squalomix Consortium
Kuraku, S.; Kawaguchi, Y.; Misawa, R.; Niwa, T.; Kadota, M.; Saito, K.; Godo, W.; Sakamoto, T.; Takagi, W.; Isobe, S.; Shirasawa, K.; Kawaguchi, A.
10.1101/2025.06.08.657570 — genomics — Posted on 2025-06-08
1189 RetiGene, a comprehensive gene atlas for inherited retinal diseases (IRDs)
Quinodoz, M.; Celik, E.; Kamdar, D.; Cancellieri, F.; Kaminska, K.; Ullah, M.; Barberan-Martinez, P.; Bouckaert, M.; Corton, M.; Delanote, E.; Fernandez-Caballero, L.; Garcia, G. G.; Holtes, L. K.; Karali, M.; Lopez, I.; Peter, V. G.; Schneider, N.; Vincke, L.; Ayuso, C.; Banfi, S.; Bocquet, B.; Coppieters, F.; Cremers, F.; Inglehearn, C.; Iwata, T.; Kalatzis, V.; Koenekoop, R. K.; Millan, J. M.; Sharon, D.; Toomes, C.; Rivolta, C.
10.1101/2025.06.08.653722 — genetics — Posted on 2025-06-08
1191 Combining population genomics with ancient DNA to understand island colonization history of the Madagascar turtle dove
Dwivedi, N.; Heighton, S. P.; Laso-Jadart, R.; Verry, A. J. F.; Nieto-Heredia, A.; Lesturgie, P.; Khost, D.; Bohec, M.; Sackton, T. B.; Chikhi, L.; Orlando, L.; Hume, J. P.; Achaz, G.; Theves, C.; Mona, S.; Warren, B. H.
10.1101/2025.06.05.658009 — evolutionary biology — Posted on 2025-06-08
1195 Variability in foraging ranges of snow petrels and implications for breeding distribution and use of stomach-oil deposits as proxies for paleoclimate
Wakefield, E. D.; McClymont, E. L.; Descamps, S.; Grecian, W. J.; Honan, E. M.; Rix, A. S.; Robert, H.; Sandoy Brathen, V.; Phillips, R. A.
10.1101/2025.06.06.658237 — ecology — Posted on 2025-06-08
1200 Regulatory elements of pancreas development license the initiation of pancreatic ductal adenocarcinoma
Ballester, M.; Kurilla, A.; Dai, Y.; Maurer, C.; Espinet, E.; Hoj, K.; Marisch Delgado, A.; Seymour, P. A.; Omar, S.; Rift, C. V.; Hasselby, J.; Klaussen, P.; Vilmann, P.; Sandelin, A.; Arnes Perez, L.
10.1101/2025.06.06.658264 — cell biology — Posted on 2025-06-08
1201 EndoNB: A general strategy to study the internalization of cell surface proteins
Lenaerts, A.-S.; Krishtal, J.; Arima, T.; Leskovar, N.; Zeinoddin, N.; Almeida-Souza, L.
10.1101/2025.06.08.658482 — cell biology — Posted on 2025-06-08
1202 Sensory stimuli and cilium trafficking defects trigger the release of ciliary extracellular vesicles from multiple ciliary locations
Lobo, T. G. Q.; Haasnoot, G. H.; Nawrocka, A.; Bruggeman, C. W.; Razzauti, A.; Peterman, E. J. G.; Laurent, P.
10.1101/2025.06.06.658075 — cell biology — Posted on 2025-06-08
1203 Integrative Chemical Genetics Platform Identifies Condensate Modulators Linked to Neurological Disorders
Poch, D.; Mukherjee, C.; Mallik, S.; Todorow, V.; Kuiper, E. F. E. J.; Dhingra, N.; Surovtseva, Y. V.; Schlieker, C.
10.1101/2025.06.07.658469 — cell biology — Posted on 2025-06-08
1204 The STORE.2 model of the T cell proliferative phase considering c-Myc
Christian, D. A.; Bhartt, T. P. S.; Lanzar, Z.; Seyyedizadeh, S. F.; Hunter, C. A.; Adams, T. A.
10.1101/2025.06.05.658086 — immunology — Posted on 2025-06-08
1208 Single-cell and cell-type-level insights into stress-driven immune regulation relevant to disease
Benavides, S.; Kosyk, O.; Carpenter, L.; Georgiou, C.; Miller, B. C.; Stanley, N.; Zannas, A. S.
10.1101/2025.06.05.658150 — immunology — Posted on 2025-06-08
1209 Comparing electromyography, accelerometry, and visual inspection to assess the resting motor threshold for transcranial magnetic stimulation
Hamoline, G.; Lunardi, A. E.; Moreno-Verdu, M.; Waltzing, B. M.; Van Caenegem, E. E.; MacAteer, S.; Hardwick, R. M.
10.1101/2025.06.04.657787 — neuroscience — Posted on 2025-06-08
1210 Astrocytic CREB regulates transcriptional, neuronal, and behavioral responses to cocaine
Holt, L. M.; Minier-Toribio, A.; Futamura, R.; Browne, C. J.; Martinez-Rivera, F. J.; Markovic, T.; Gyles, T. M.; Yeh, S.-y.; Parise, E. M.; Rivera, M.; Brenner, C.; Yim, Y. Y.; Kondev, V.; Estill, M.; Yan, S.; Keane, E.; Labanca, A.; Rojas, G.; Dong, Y.; Shen, L.; Nestler, E. J.
10.1101/2025.06.04.657899 — neuroscience — Posted on 2025-06-08
1214 Disrupted Forward Connectivity in Parieto-temporal Network Impairs Memory Performance in Alzheimer's Disease
Suksangkharn, Y.; Schott, B. H.; Zeidman, P.; Vockert, N.; Lattmann, R.; Schütze, H.; Yakupov, R.; Peters, O.; Hellmann-Regen, J.; Preis, L.; Ersözlü, E.; Priller, J.; Spruth, E. J.; Gemenetzi, M.; Schneider, A.; Fliessbach, K.; Wiltfang, J.; Bartels, C.; Rostamzadeh, A.; Glanz, W.; Incesoy, E. I.; Teipel, S.; Kilimann, I.; Goerss, D.; Laske, C.; Spottke, A.; Kronmüller, M.; Brosseron, F.; Lüsebrink, F.; Schmid, M.; Kleineidam, L.; Stark, M.; Hetzer, S.; Dechent, P.; Scheffler, K.; Jessen, F.; Maass, A.; Düzel, E.; Ziegler, G.
10.1101/2025.06.05.658022 — neuroscience — Posted on 2025-06-08
1216 Sex-specific Effects of Outdoor Air Pollution on Subcortical Microstructure and Weight Gain: Findings from the ABCD Study
Rivas-Fernandez, M. A.; Ottino-Gonzalez, J.; Esaian, S.; Goldman, V.; Herting, M. M.; Alderete, T. L.; Adise, S.
10.1101/2025.06.04.657916 — neuroscience — Posted on 2025-06-08
1220 Adolescent alcohol consumption alters sex-specific behaviors associated with prefrontal functional connectivity in mice
Seemiller, L. R.; Unsal, H. S.; Xie, Y.; Hossain, M. S.; Tuttle, K.; Johnson-Dendy, B.; McDonald, E.; Drew, P. J.; Zhang, N.; Crowley, N. A.
10.1101/2025.06.05.658112 — neuroscience — Posted on 2025-06-08
1221 Genomic structural equation modeling of impulsivity and risk-taking traits reveals three latent factors distinctly associated with brain structure and development
Shishikura, M.; Liu, L.; Yu, E.; Zhu, R.; Vilar-Ribo, L.; Cupertino, R. B.; Palmer, A. A.; Sanchez-Roige, S.; Vainik, U.; Morys, F.; Gan-Or, Z.; Misic, B.; Dagher, A.
10.1101/2025.06.05.657840 — neuroscience — Posted on 2025-06-08
1222 Non-obese genetic type 2 diabetes causes brain and behavioral hallmarks of chronic stress
Romani-Perez, M.; Henry, M.; Pajot, C.; Bailbe, D.; Brossaud, J.; Buyannemekh, K.; Lucia, P.; Foury, A.; Rincel, M.; Lepinay, A.; Portha, B.; Turner, J.; Movassat, J.; DARNAUDERY, M.
10.1101/2025.06.08.658427 — neuroscience — Posted on 2025-06-08
1224 Macrophages amplify the spontaneous activity of damaged sensory neurons in a human co-culture model of neuropathic pain
Chrysostomidou, P.; Hore, Z.; Somma, D.; Vlachaki Walker, J. M.; Diallo, K.; Titterton, H.; Elmesmari, A.; Kurowska-Stolarska, M.; Denk, F.; Weir, G. A.
10.1101/2025.06.05.656880 — neuroscience — Posted on 2025-06-08
1225 Neurally-informed modelling unravels a single evidence accumulation process for choices and subsequent confidence reports
Grogan, J. P.; Vermeylen, L.; Mannion, S.-L.; McCabe, C.; Monakhovych, D.; Desender, K.; O'Connell, R. G.
10.1101/2025.06.05.658071 — neuroscience — Posted on 2025-06-08
1226 An amygdalopontine pathway promotes motor programs of ingestion
Lafferty, D. S.; Isaac, J.; Wolcott, J. S.; Phan, A.; Reck, L.; Lutas, A.
10.1101/2025.06.05.657686 — neuroscience — Posted on 2025-06-08
1228 Reduced inhibition, bursting, and accelerated oscillations drive early hippocampal hyperactivity in Alzheimer's disease
Meftah, S.; Kang, S.; Liu, M.; Wang, X.; Topcu, A. N.; Abad, M. M.; Koszeghy, A.; Wan, L.; Mullin, C.; Zoupi, L.; Gan, J.
10.1101/2025.06.05.658038 — neuroscience — Posted on 2025-06-08
1229 Gut miRNA regulates gut microbiome and Alzheimer pathology in App-knock-in mice
Hao, W.; Luo, Q.; Szabo, I. M.; Gasparoni, G.; Tierling, S.; Quan, W.; Chang, H.-F.; Wu, G.; Schulze-hentrich, J.; Liu, Y.
10.1101/2025.06.05.658056 — neuroscience — Posted on 2025-06-08
1230 UNWANTED AXON GROWTH: PTEN AND THE SUPPRESSION OF AXON PLASTICITY IN ADULT NERVES
Eaton, S.; Komirishetty, P.; Larouche, M.; Areti, A.; Ong, H.; Martinez, J.; Zochodne, D. W.
10.1101/2025.06.04.657750 — neuroscience — Posted on 2025-06-08
1231 Comparative chemosensory mechanisms underlying larval foraging and competitive advantage in Aedes albopictus and Aedes aegypti
Perets, D.; Ke, H.; Campli, G.; Sar-Shalom, E.; Krsticevic, F.; Yakir, E.; Waterhouse, R. M.; Wang, Y.; Papathanos, P. A.; Bohbot, J. D.
10.1101/2025.06.07.658027 — neuroscience — Posted on 2025-06-08
1232 Left Area PF as a Neural Marker of Technical Reasoning
Federico, G.; Ilardi, C. R.; Marangolo, P.; Bryche, C.; Metaireau, M.; Bluet, A.; Lesourd, M.; Rossetti, Y.; Osiurak, F.
10.1101/2025.06.04.657853 — neuroscience — Posted on 2025-06-08
1233 Visual blur disrupts the kinematic and temporal aspects of reach-grasp-lift movements.
Sheppard, W. E. A.; Campagnoli, C.; Wilkie, R. M.; Baraas, R. C.; Coats, R. O.
10.1101/2025.06.05.658186 — neuroscience — Posted on 2025-06-08
1237 iTissue
Zambrana, C.; Malod-Dognin, N.; Przulj, N.
10.1101/2025.06.04.657816 — systems biology — Posted on 2025-06-08
1238 Transposon-plasmid nesting enables fast response to fluctuating environments
Ha, Y.; Maddamsetti, R.; Chen, X.; Simsek, E.; Lee, D.; Son, H.; Lee, C.; Kussell, E.; You, L.
10.1101/2025.06.04.657954 — systems biology — Posted on 2025-06-08
1242 Biofabrication of gold nanoparticles (GNPs) synthesized from Dillenia indica leaves with their anticancer, antibacterial, and antioxidant activities.
GUPTA, A.; Pandey, B. C.; Yaseen, M.; Kushwaha, R.; Verma, J.; Chaudhary, P.; Manna, P. P.; Manhas, R. K.; Tiwari, I.; Kumari, N.
10.1101/2025.06.05.653664 — plant biology — Posted on 2025-06-08
1249 Stereospecific rapid activation of Transcription Factor EB (TFEB) by Levacetylleucine (NALL)
Galione, A.; Platt, F. M.; Churchill, G. C.; Patterson, M. C.; Factor, M.; Fields, T.; Davis, L. C.; Strupp, M.
10.1101/2025.06.06.657607 — pharmacology and toxicology — Posted on 2025-06-08
1250 Gut bacterial metabolite imidazole propionate potentiates Alzheimer's disease pathology
Vemuganti, V.; Kang, J. W.; Zhang, Q.; Martinez, R. A.; Harpt, J. L.; Harding, S. J.; Deming, Y.; Johnson, S. C.; Asthana, S.; Zetterberg, H.; Blennow, K.; Engelman, C.; Ulland, T. K.; Bäckhed, F.; Bendlin, B. B.; Rey, F. E.
10.1101/2025.06.08.657719 — pathology — Posted on 2025-06-08
1251 Single JAK2-V617F hematopoietic stem cells can initiate MPN in transplantations into non-conditioned recipient mice
Kimmerlin, Q.; Hilpert, M.; Hansen, N.; Guy, A.; Usart, M.; Stetka, J.; Sobieralski, P.; Fonseca, T. A.; Hao-Shen, H.; Skoda, R. C.
10.1101/2025.06.08.657469 — cancer biology — Posted on 2025-06-08
1253 Cryo-EM Sample Preparation with Soft-Landing and Laser Flash Melting
Barrass, S. V.; Esser, T. K.; Mowry, N. J.; Eriksson, L.; Hruby, J.; Seeley, L. T.; Curtis, W. A.; Baker, L. A.; Drabbels, M.; Rauschenbach, S.; Lorenz, U. J.
10.1101/2025.06.05.657968 — biophysics — Posted on 2025-06-08
1254 Enabling Real-Time Fluctuation-Based Super ResolutionImaging
Komen, J.; Tekpinar, M.; Huo, R.; De Zwaan, K.; Tomen, N.; Grussmayer, K.
10.1101/2025.06.05.658028 — biophysics — Posted on 2025-06-08
1265 Detection and Classification of Cervical Cancer Using Optimized Deep Learning Approach
Lalitha, S.; Baiju, B. V.; Mathivanan, S. K.; Nagappan, P.; Tyagi, C. S.; Mallik, S.
10.1101/2025.06.05.657998 — bioengineering — Posted on 2025-06-08
1268 Single-cell metabolic imaging and digital scoring of fat tissue remodeling by label-free metabolic imaging
Kim, M.; Berger, C.; Wolf, A.; Peteranderl, A.; Klingenspor, M.; Ntziachristos, V.; Li, Y.; Pleitez, M. A.
10.1101/2025.06.06.658032 — bioengineering — Posted on 2025-06-08
1269 Structural Basis for a Scaffolding Role of the COM Domain in Nonribosomal Peptide Synthetases
Diecker, J.; Hermanns, B.; Rueschenbaum, J.; Rasche, R.; Doerner, W.; Schroeder, A.; Kuemmel, D.; Mootz, H. D.
10.1101/2025.06.08.658476 — biochemistry — Posted on 2025-06-08
1273 Remote automated delivery of mechanical stimuli coupled to brain recordings in behaving mice
Burdge, J.; Jhumka, A.; Khan, A.; Ogundare, S.; Baer, N.; Fulton, S.; Kaplan, A.; Bistis, B.; Foster, W.; Thackray, J.; Toussaint, A.; Li, M.; Morizawa, Y. M.; Nazarian, J.; Yadessa, L.; George, A.; Delinois, A.; Mayiseni, W.; Loran, N.; Yang, G.; Margolis, D. J.; Abraira, V. E. G.; Abdus-Saboor, I.
10.1101/2024.05.06.592101 — neuroscience — Posted on 2025-06-08
1274 Integrated Histology and Molecular Profiling of Postmortem Human Auditory and Vestibular Organs via a Poly(Methyl Methacrylate)-Based Workflow
Baechinger, D.; Peyton, B.; Neubauer, J.; Dharmarajan, A.; Zhu, M.; O'Malley, J. T.; Kallupurackal, V.; Senese, S.; Brown, A.; Wunderlin, S.; Kreutzer, S.; Weiss, N. M.; Richter, H.; Dalbert, A.; Roeoesli, C.; Kipar, A.; Varga, Z.; von Rechenberg, B.; Amr, S.; Eckhard, A. H.
10.1101/2025.06.04.657716 — pathology — Posted on 2025-06-08
1275 Paclitaxel causes de novo induction of invasive breast cancer cells by repolarizing tumor-associated macrophages
Friedman-DeLuca, M.; Karagiannis, G. S.; Duran, C. L.; Eddy, R. J.; Shukla, S.; Li, J.; Condeelis, J. S.; Oktay, M. H.; Entenberg, D.
10.1101/2025.01.13.632767 — cancer biology — Posted on 2025-06-08
1276 Identification of disease-specific vulnerability states at the single-cell level
D'Antuono, M.; Sharp, M.; Chowdary, R.; Ivan, M. E.; Komotar, R. J.; Suter, R. K.; Ayad, N. G.
10.1101/2024.12.04.626873 — cancer biology — Posted on 2025-06-08
1277 NRCAM variant defined by microexon skipping is an essential, antigenically distinct, and targetable surface proteoform in high-grade gliomas
Sehgal, P.; Naqvi, A. S.; Higgins, M.; Liu, J.; Harvey, K.; Jarroux, J.; Kim, T.; Mankaliye, B.; Mishra, P.; Watterson, G.; Fine, J.; Davis, J.; Hayer, K. E.; Castro, A.; Mogbo, A.; Drummer, C.; Martinez, D.; Koptyra, M. P.; Ang, Z.; Wang, K.; Farrel, A.; Quesnel-Vallieres, M.; Barash, Y.; Spangler, J. B.; Rokita, J. L.; Resnick, A. C.; Tilgner, H. U.; DeRaedt, T.; Powell, D. J.; Thomas-Tikhonenko, A.
10.1101/2025.01.09.631916 — cancer biology — Posted on 2025-06-08
1278 Direct observation of conformational dynamics of intrinsically disordered proteins at the single-molecule level
Zargarbashi, S.; Dominguez, C.; Peters, M.; Yousefi, A.; Munday, S.; Wang, Y.; Chatterjee, S.; Hudson, A.; Gordon, R.; Mellor, C. J.; Xu, L.; Rahmani, M.; Ying, C.
10.1101/2025.05.26.656162 — biophysics — Posted on 2025-06-08
1279 Discovery of excited state proton transfer in flavin-based fluorescent protein with large Stokes shift
Nikolaev, A.; Markeeva, E.; Maksimov, E. G.; Yudenko, A.; Tropina, E. V.; Boldyrev, K. N.; Nikolaeva, Y. S.; Cherepanov, D. A.; Kovalev, K.; Yang, Y.; Borshchevskiy, V. I.; Kuznetsova, E.; Kuzmin, A.; Semenov, O.; Remeeva, A.; Gushchin, I.
10.1101/2025.06.07.658458 — biochemistry — Posted on 2025-06-08
1280 The Na+-pumping mechanism driven by redox reactions in the NADH-quinone oxidoreductase from Vibrio cholerae relies on dynamic conformational changes
Ishikawa-Fukuda, M.; Seki, T.; Kishikawa, J.-i.; Takahiro, M.; Okazaki, K.-i.; Kato, T.; Barquera, B.; Miyoshi, H.; Murai, M.
10.1101/2025.06.01.656757 — biochemistry — Posted on 2025-06-08
1282 Developmental dynamic transcriptomics reveals multiple effectors and transcription factors critical for Ditylenchus destructor parasitism
Chen, Y.; Zhang, S.; Zhou, Y.; Wang, X.; Bo, D.; Liao, Y.; Hu, B.; Zhang, Y.; Ashry, N. M.; Peng, D.; Sun, M.; Dai, D.
10.1101/2025.06.02.657539 — genomics — Posted on 2025-06-08
1283 Large-scale skin metagenomics reveals extensive prevalence, coordination, and functional adaptation of skin microbiome dermotypes across body sites
Li, C.; Ravikrishnan, A.; Wijaya, I.; Naim, A. N. M.; Gounot, J.-S.; Wearne, S.; On, Y. Y.; Ho, E. X. P.; Png, E.; Kwah, J. S.; Chandra, S. H. V.; Ang, Q. Y.; Chia, M.; Amanda, N. H. Q.; Ramaswami, S.; Yew, Y. W.; Loh, M.; Ong, R. Y.; Ng, F.; Lee, S. H.; Chan, J.; The HELIOS Study team, ; Regina, V. R.; Dawson, T.; Chambers, J.; Common, J.; Nagarajan, N.
10.1101/2025.04.24.650393 — genomics — Posted on 2025-06-08
1284 Short chain fatty acids regulate the chromatin landscape and distinct gene expression changes in human colorectal cancer cells
Kabir, T.; Connamacher, C. A.; Nadeem, Z.; Paul, M. R.; Smutny, M. R.; Lawler, Z. K.; Djomo, A. M.; Carroll, T.; Gates, L. A.
10.1101/2025.05.07.652677 — cell biology — Posted on 2025-06-08
1289 Biliverdin Reductase A is a major determinant of neuroprotective Nrf2 signaling
Vasavda, C.; Kothari, R.; Kaidery, N. A.; Chakraborty, S.; Tripathi, S. J.; Dhindsa, R. S.; Saberi, S.; Lefler, J. E.; Kothari, P.; Chaubey, K.; Snowman, A. M.; Ostrowski, M. C.; Barone, E.; Iyer, L. M.; Aravind, L.; Sharma, S. M.; Pieper, A. A.; Thomas, B.; Snyder, S. H.; Paul, B. D.
10.1101/2025.06.04.657936 — neuroscience — Posted on 2025-06-08
1292 An Integrated In Vitro Platform and Biophysical Modeling Approach for Studying Synaptic Transmission in Isolated Neuronal Pairs
Amos, G.; Vasiliauskaite, V.; Duru, J.; Saramago, M. L. A.; Schmid, T.; Suter, A.; Torren, F. C.; Küchler, J.; Ruff, T.; Vörös, J.; Vulic, K.
10.1101/2025.06.04.657933 — neuroscience — Posted on 2025-06-08
1294 Interprotomer Communication and Functional Asymmetry in H/ACA snoRNPs
Singh Panwar, H.; Vos, T. J.; Xie, X.; Jang, H. S.; Lee, H.; Sheldon, R.; Worden, E. J.; Kothe, U.
10.1101/2025.06.07.658439 — biochemistry — Posted on 2025-06-08
1295 Mechanisms of KCNQ1 gating modulation by KCNE1/3 for cell-specific function
Cui, C.; Zhao, L.; Kermani, A. A.; Du, S.; Pipatpolkai, T.; Jiang, M.; Chittori, S.; Tan, Y.; Shi, J.; Delemotte, L.; Cui, J.; Sun, J.
10.1101/2025.06.08.658478 — biochemistry — Posted on 2025-06-08
1296 A human ex vivo model of radiation-induced skin injury reveals p53-driven DNA damage signaling and recapitulates a TGFβ fibrotic response
Dodson, C.; Bilik, S. M.; DiBartolomeo, G.; Pachalis, H.; Siegfried, L.; Johnson, J. A. K.; Thaller, S. R.; Pastar, I.; Tomic-Canic, M.; Griswold, A. J.; Stone, R. C.
10.1101/2025.06.04.657901 — genomics — Posted on 2025-06-08
1298 Molecular profiling of bovine primordial germ cell specification and migration onset reveals a conserved program in bilaminar disc embryos
Guiltinan, C.; Botigelli, R. C.; Arcanjo, R. B.; Candelaria, J. I.; Lanzon, L. F.; Smith, J. M.; Becerra-Cortes, G.; Denicol, A. C.
10.1101/2025.06.04.657951 — developmental biology — Posted on 2025-06-08
1299 Spatial characterization of microbiota profiles along the gut in a widely used mouse model: effects of high-fat diet and fructooligosaccharides
Taillandier, P.; Voland, L.; Debedat, J.; Archambeau, A.; Dussaud, S.; Amouyal, C.; Patino-Navarrete, R.; Rey, F. E.; Adriouch, S.; Belda, E.; Clement, K.; Le Roy, T.
10.1101/2025.06.08.658095 — microbiology — Posted on 2025-06-08
1300 Characterization of a Novel Cell Wall-Associated Nucleotidase of Enterococcus faecalis that Degrades Extracellular c-di-AMP
Rivera, A. G. M.; Bala, A.; Casella, L. G.; Brunson, D. N.; Patel, A. M.; Wongso, E.; Flores-Mireles, A. L.; Lemos, J. A.
10.1101/2025.06.08.658492 — microbiology — Posted on 2025-06-08
1301 Competing gene regulatory networks drive naive and memory B cell differentiation
Demela, P.; Esposito, L.; Marchesan, P.; Bolognini, D.; Giacopuzzi, E.; Ricciardelli, E.; Ferrari, P.; Bombelli, S.; Peano, C.; Prati, D.; Valenti, L.; Soskic, B.
10.1101/2025.06.04.657836 — immunology — Posted on 2025-06-08
1302 Abrogating TGFβ signaling in TCR-engineered T cells and enhancing antigen processing by tumor cells promotes sustained therapeutic activity in pancreatic ductal adenocarcinoma
Tsai, A. K.; Rollins, M. R.; Ellefson, M. A.; Schmiechen, Z. C.; Burrack, A. L.; Hulbert, A.; Qian, G.; Zhang, H.; Provenzano, P.; Cruz-Hinojoza, E.; Butler, J. Z.; Smith, O. C. G.; O'Flanagan, S. D.; Krause, J.; Hickok, G. H.; Masopust, D.; Hingorani, S. R.; Greenberg, P. D.; Stromnes, I. M.
10.1101/2025.06.04.657887 — immunology — Posted on 2025-06-08
1303 IL-12 Secreting CAR-T Cells Reprogram the Tumor Microenvironment and Improve Efficacy Against Heterogeneous Models of Glioblastoma
Shen, S.; MOHAN, A.; Hotchkiss, K. M.; Quackenbush, S.; Patel, K.; Moelker, E.; Swartz, A.; Suryadevara, C.; Wilkinson, D.; Fecci, P.; Sanchez-Perez, L.; Sampson, J.; Patel, A.
10.1101/2025.06.04.657937 — immunology — Posted on 2025-06-08
1305 Glycated alpha-synuclein assemblies cause distinct Parkinsons disease pathogenesis in mice
Rajan, A.; Varghese, A.; Hashardeen, S. P.; Babu, A. T.; Vijayan, V.; Thakur, P.
10.1101/2025.06.04.657879 — neuroscience — Posted on 2025-06-08
1309 Engineering gene expression dynamics via self-amplifying RNA with drug-responsive non-structural proteins
Yousefpour, P.; Gregory, J. R.; Si, K.; Lonzaric, J.; Li, Y.; Wang, J.; Qureshi, K.; Ledbetter, A.; Melo, M. B.; Lemnios, A. A.; Dye, J.; Remba, T. K.; Yeung, R.; Rodriguez, L.; Guereca, M.; Wu, S.; Zhang, Y.; Dong, Y.; Weiss, R.; Irvine, D. J.
10.1101/2025.06.08.658495 — bioengineering — Posted on 2025-06-08
1311 Metabolic tuning enables immediate adaptation to energy stress in yeast
Bexley, K.; Ristova, M.; Sharma, S.; Spanos, C.; Chabes, A.; Tollervey, D.
10.1101/2025.06.06.658098 — molecular biology — Posted on 2025-06-08
1313 Remodeling of tRNA modification in Trypanosoma cruzi life forms
Silva, H. G.; De Freitas Nascimento, J.; Braga, M. S.; Silber, A. M.; Waldor, M.; da Cunha, J. P.; Kimura, S.
10.1101/2025.06.07.658256 — molecular biology — Posted on 2025-06-08
1314 TITAN-RNA: A hybrid-capture sequencing panel detects known and unknown Flaviviridae for diagnostics and vector surveillance
Murrell, C. M.; Sabaawy, A.; Wang, X.; Hashimoto, N.; Ceres, K.; Sun, Y.; Zehr, J. D.; Lehane, A.; Mader, E.; Bailey, N.; Lilly, M. V.; Plimpton, L.; Reboul, G.; Brown, J. J.; Sams, K. L.; Singh, L.; Seiz, E.; Bourgikos, E.; Vogels, C. B. F.; Ciota, A.; Schnurr, V.; Grenier, J. K.; Berthet, X.; Bento, A. I.; Harrington, L. C.; Diuk-Wasser, M.; Olarte-Castillo, X.; Goodman, L. B.
10.1101/2025.06.08.658352 — microbiology — Posted on 2025-06-08
1316 Preliminary insights into salivary proteomic versus targeted biomarker profiles associated with acute physical fatigue
Lindsey, B.; Bowden, K.; Shaul, Y.; Petricoin, E.; Caswell, S. V.; Alhammad, R.; Elayadi, A. N.; Martin, J.
10.1101/2025.06.04.657971 — physiology — Posted on 2025-06-08
1317 Complex rheology of condensin in entangled DNA
Conforto, F.; Valdes, A.; Vanderlinden, W.; Michieletto, D.
10.1101/2025.06.04.657969 — biophysics — Posted on 2025-06-08
1321 Stress-Induced Alteration of Small Extracellular Vesicles Drives Amyloid-Beta Sequestration and Exacerbates Alzheimer's Disease Pathogenesis
Zehra, S.; Rai, S.; Rani, K.; Choudhury, S. D.; Rai, H.; Bhowmik, S.; Mohan, N.; Gupta, A.; Chatterjee, P.; Reddy, T. J.; Rani, N.; Modi, G. P.; Nikolajeff, F.; Kumar, S.
10.1101/2025.05.23.655679 — neuroscience — Posted on 2025-06-08
1323 PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP
Wang, J.; Shi, Y.; Wang, Y.; Shen, Y.; Liu, H.; Sun, S.; Wang, Y.; Zhou, X.; Zhou, Y.; Zeng, X.; Li, J.; Chen, Q.
10.1101/2024.07.23.604769 — cancer biology — Posted on 2025-06-08
1325 Killer Toxin K28 resistance in yeast relies on COG complex mediated trafficking of the defence factor Ktd1
Laidlaw, K.; Nadir, H.; Milburn, A.; Cruz, M.; Stanislovas, J.; Droop, A.; MacDonald, S.; Andreev, I.; Leech, A.; Ungar, D.; Sadhu, M. J.; MacDonald, C.
10.1101/2024.12.20.629825 — cell biology — Posted on 2025-06-08
1326 Co-release of opposing signaling molecules controls the escalation and release of aggression
Gatlin, R. E.; Gagon, J.; Kwak, D.; Park, S.; Walker, H.; Kroheim, L.; Everett, T.; Covington, A.; Fluck, M. M.; Zickmund, T.; Frost, N. A.; Zelikowsky, M.
10.1101/2025.03.13.643119 — neuroscience — Posted on 2025-06-08
1327 Convergent and divergent brain-cognition relationships during development revealed by cross-sectional and longitudinal analyses in the ABCD Study
Xie, Y.; Zhang, S.; Orban, C.; Ooi, L. Q. R.; Kong, R.; Floris, D. L.; Zuo, X.-N.; Dhamala, E.; Holmes, A. J.; Uddin, L. Q.; Nichols, T. E.; Di Martino, A.; Yeo, B. T. T.
10.1101/2025.06.06.658294 — neuroscience — Posted on 2025-06-08
1333 Chromosome-length genome assembly of Uta stansburiana and gene expression data reveal fast pace-of-life comes with environmental stability
Fellows, S.; Araya-Donoso, R.; Davalos-Dehullu, E.; Khan, R.; Weisz, D.; Dudchenko, O.; Aiden, E. L.; Munguia-Vega, A.; Dolby, G. A.; Edwards, D. L.
10.1101/2025.05.28.656178 — evolutionary biology — Posted on 2025-06-08
1336 Genetic modulation of immune gene co-expression in the aged mouse hippocampus by the Apbb1ip locus
Tomkins, J. E.; Methi, A.; Bouland, G.; Doludda, B.; Murphy, K.; Miller, J. A.; Overall, R. W.; Mozhui, K.
10.1101/2025.06.04.657838 — bioinformatics — Posted on 2025-06-08
1339 Direct electrical stimulation of the human amygdala enhances recognition memory for objects but not scenes
Wahlstrom, K. L.; Campbell, J. M.; Hollearn, M. K.; Swift, J.; Adamek, M.; Blanpain, L.; Xie, T.; Davis, T.; Brunner, P.; Hamann, S. B.; Arain, A.; Eisenman, L.; Rolston, J. D.; Rahimpour, S.; Manns, J. R.; Willie, J. T.; Inman, C. S.
10.1101/2025.06.05.658078 — neuroscience — Posted on 2025-06-07
1341 Ketogenic diet dampens excitatory neurotransmission by shrinking synaptic vesicle pools
Stunault, M. I.; Deng, P.; Periandri, E. M.; Vitorino, F. N.; Barfield, A. J.; Ponce, R. J.; Garcia, B. A.; Egervari, G.; Klyachko, V. A.; Ashrafi, G.
10.1101/2025.06.04.657883 — neuroscience — Posted on 2025-06-08
1342 RNA Dynamics Regulate Transcriptional Condensate Vivacity to Drive Gene Coordination
Ogami, K.; Zheng, M. M.; Yoshino, S.; Sugimoto, Y.; Seida, M.; Mori, T.; Yoshizawa, R.; Onimaru, K.; Kadota, M.; Kuraku, S.; Suzuki, K. G. N.; Cisse, I. I.; Sharp, P. A.; Suzuki, H. I.
10.1101/2025.06.06.658161 — molecular biology — Posted on 2025-06-07
1344 Engineering lung-sensing T cells using synthetic receptors targeting RAGE
Jacob, A.; Whitty, C.; Lupica, G.; Badwal, E.; Ren, X.; Qiu, W.; Yu, W.; Tonai, Y.; Camara Serrano, J. A.; Simic, M.; Lim, W. A.; Allen, G.; Sheppard, D.
10.1101/2025.06.06.658315 — synthetic biology — Posted on 2025-06-07
1345 Integrated Histology and Molecular Profiling of Postmortem Human Auditory and Vestibular Organs via a Poly(Methyl Methacrylate)-Based Workflow
Baechinger, D.; Peyton, B.; Neubauer, J.; Dharmarajan, A.; Zhu, M.; O'Malley, J. T.; Kallupurackal, V.; Senese, S.; Brown, A.; Wunderlin, S.; Kreutzer, S.; Weiss, N. M.; Richter, H.; Dalbert, A.; Roeoesli, C.; Kipar, A.; Varga, Z.; von Rechenberg, B.; Amr, S.; Eckhard, A. H.
10.1101/2025.06.04.657716 — pathology — Posted on 2025-06-07
1346 Synthetic cargo adaptors reveal molecular features that can enhance dynein activation
Siva, A.; Gillies, J. P.; de Borchgrave, A.; Garrott, S. R.; Mishra, R.; El Jbeily, R.; Clarke, R.; Conklin, C.; Gibson, D.; Zang, J. L.; DeSantis, M. E.
10.1101/2025.06.06.658359 — biophysics — Posted on 2025-06-07
1347 Lizards on a sky archipelago: Genomic approaches to the evolution of the mountain genus Iberolacerta
Talavera, A.; Burriel-Carranza, B.; Mochales-Riano, G.; Estarellas, M.; Arribas, O.; Tejero-Cicuendez, H.; Salces-Ortiz, J.; Fernandez-Guiberteau, D.; Amat, F.; Niell, M.; Fernandez, R.; Mikheyev, A. S.; Carranza, S.
10.1101/2025.06.04.657811 — genomics — Posted on 2025-06-07
1349 Variation in inbreeding depression within and among Caenorhabditis species
Rockman, M. V.; Bernstein, M. R.; Caglar, D.; Cattani, M. V.; Chang, A. S.; Kaur, T.; Noble, L. M.; Paaby, A. B.
10.1101/2025.06.04.657873 — evolutionary biology — Posted on 2025-06-07
1354 Targeting Langerhans cells using a modular mannosylated nucleic acid-based vaccine platform
Vinther, S. C.; Resag, A.; Le, K. T. T.; Zelle-Rieser, C. C.; Strandt, H.; Malle, M. G.; Christiansen, S. H.; Del Frari, B.; Stigger, T.; Schilling, B.; Wohlfarth, J.; Thiel, S.; Valero, J.; Stoitzner, P.; Kjems, J.
10.1101/2025.06.04.657560 — molecular biology — Posted on 2025-06-07
1355 MRTF-dependent cytoskeletal dynamics drive efficient cell cycle progression
Nielsen, J. C.; Benito-Jardon, M.; Petrela, N. C.; Diring, J.; Bellamy, S.; Treisman, R.
10.1101/2025.06.06.657372 — molecular biology — Posted on 2025-06-07
1356 H3K4me1 directs H3K36me2 and H3K36me3 deposition in land plants
Wu, J.; Wang, J.; Du, K.; Li, Y.; Xie, W.; He, C.; Xing, Q.; Li, X.; Zhu, X.; Wu, Z.; Wu, X.; Shen, W.-H.; Lan, F.; Gan, J.; Liu, B.; Dong, A.
10.1101/2025.06.06.658275 — molecular biology — Posted on 2025-06-07
1358 BARTharm: MRI Harmonization Using Image Quality Metrics and Bayesian Non-parametric
Prevot, E.; Haering, D. A.; Gaetano, L.; Shinohara, R. T.; Holmes, C.; Nichols, T. E.; Ganjgahi, H.
10.1101/2025.06.04.657792 — neuroscience — Posted on 2025-06-07
1362 VesicleVoyager: In vivo selection of surface displayed proteins that direct extracellular vesicles to tissue-specific targets
Kawai-Harada, Y.; Mardikoraem, M.; Makela, A. V.; Lauro, K.; Lam, J.; Contag, C. H.; Woldring, D. R.; Harada, M.
10.1101/2025.06.04.657858 — bioengineering — Posted on 2025-06-07
1363 YAP/TAZ mechanotransduction is a fast cellular response to subnuclear adhesions revealed by mechanically dynamic substrates
Gandin, A.; Torresan, V.; Pelosin, M.; Vanni, G.; Busetto, R.; Citron, A.; Suli, A.; Panciera, T.; Zanconato, F.; Piccolo, S.; Brusatin, G.
10.1101/2025.06.04.656127 — bioengineering — Posted on 2025-06-07
1364 rtmsEcho: An Open-Source R Package for Automated Analysis of Acoustic Ejection Mass Spectrometry Data
Rimmer, M. A.; Twarog, N. A.; Ranathunge, T.; Wang, J.; Li, Y.; Chen, T.; Shelat, A.; Yang, L.
10.1101/2025.06.05.658081 — biochemistry — Posted on 2025-06-07
1365 A secreted fatty acid- and retinol- binding protein from Heligmosomoides polygyrus suppresses host macrophage polarization
Azizpor, P.; Montoya, J.; Eyabi, F.; Ramirez, J.; Hill, T.; Pena, R.; Mishra, M.; Boulanger, M.; Dillman, A. R.
10.1101/2025.06.05.657999 — biochemistry — Posted on 2025-06-07
1367 STARR-CRAAVT: A platform to design cell type-specific regulatory elements for next-generation gene therapy
Becker, R.; Choudhury, P.; Oti, M.; Fouani, Y.; Strobel, B.; Ketterer, S.; Rumpel, S.; Park, J.; Kreuz, S.; Maier, U.; Michelfelder, S.; Schön, C.
10.1101/2025.06.04.657008 — genomics — Posted on 2025-06-07
1368 The SAMM50 rs3761472 causes mitochondrial dysfunction and metabolic dysfunction-associated steatotic liver disease
Shin, H. Y.; Kim, S.; Kim, N.; Kim, U.; Kim, Y. J.; Yun, J. H.; Heo, J.; Lee, H.; Choi, J.; Jeong, I.; Kim, B.-J.
10.1101/2025.06.04.657815 — genetics — Posted on 2025-06-07
1369 Quantitative Assessment of Protein-DNA Interactions via SYBR Green Fluorescence
Wang, J.; Wang, J.; Wang, Z.; Wang, P.; Sun, S.; Li, X.; Tian, Z.; Xu, R.; Shi, Y.; Wang, Y.
10.1101/2025.06.06.658291 — molecular biology — Posted on 2025-06-07
1370 A novel Notch and WNT signaling mechanism contribute to pediatric DCM: a pathway to new therapeutics.
Nyarko, O. O.; Rausch, E.; Goff, J. R. H.; Karimpour-Fard, A.; Conard, C. S.; Hernandez-Lagunas, L.; Burns, M. P. A.; Pena, B.; Miyamoto, S. D.; Stauffer, B. L.; Sucharov, C. C.
10.1101/2025.06.07.658396 — molecular biology — Posted on 2025-06-07
1371 Regulation of essential hepatocyte functions and identity by super-enhancers in health and disease
Lin, T.; Huang, C.; Tong, C.; Xu, W.; Wang, H.; Wu, S.; Zhang, W.; Li, Y.; Liu, H.; Shao, C.; Liu, R.; Wang, S.; Munker, S.; Niess, H.; Meyer, C.; Liebe, R.; Ebert, M.; Gao, C.; Dooley, S.; Ding, H.; Zuo, L.; Wang, H.; Weng, H.
10.1101/2025.06.04.657826 — molecular biology — Posted on 2025-06-07
1373 Advancing Ligand Binding Affinity Prediction with Cartesian Tensor-Based Deep Learning
Yu, J.; Sheng, X.; Fan, Z.; Wang, Z.; Cao, D.; Hao, Y.; Zhang, Y.; rao, J.; Shao, P.; Chen, M.; Chen, K.; Teng, D.; Luo, X.; Zhang, S.; Zheng, M.
10.1101/2025.06.04.657800 — molecular biology — Posted on 2025-06-07
1377 Identification and biosynthesis of xildivaline, a novel and widespread peptide deformylase inhibitor from Gammaproteobacteria
Rill, A.; Westphalen, M.; Lamberioux, M.; Chekaiban, J.; Janin, C.; Mazel, D.; Groll, M.; Huber, E. M.; Bode, H. B.
10.1101/2025.06.07.658423 — microbiology — Posted on 2025-06-07
1378 Functional immune profiling reveals CD4+ T cell dysregulation associated with celiac disease
Farchione, A. J.; Cheon, H.; Vremec, D.; Neumann, J.; Verstappen, G. M.; Hardy, M. Y.; Margetts, M. B.; Howson, L. J.; Henneken, L. M.; Ford, M.; Tye-Din, J. A.; Heinzel, S.; Hodgkin, P. D.; Bryant, V. L.
10.1101/2025.06.06.658209 — immunology — Posted on 2025-06-07
1381 Mini-bacterioferritins: Structural insight into a new type of ferritin-like protein from an anaerobic methane-oxidising archaeon
Wissink, M.; Engilberge, S.; Leao, P.; Jansen, R. S.; Jetten, M. S. M.; Royant, A.; Welte, C. U.; Wagner, T.
10.1101/2025.06.06.658376 — biochemistry — Posted on 2025-06-07
1382 Improved EPR sensitivity for aqueous biological samples using low-volume multi-channel cells and dielectric resonators
Mett, R. R.; Anilkumar, A.; Garces, A. M.; Wehrley, J. T.; Klug, C. S.; Lerch, M. T.; Sidabras, J. W.
10.1101/2025.06.03.657726 — biophysics — Posted on 2025-06-07
1387 Parallel evolution of plant alkaloid biosynthesis from bacterial-like decarboxylases
Wood, C. X.; Jiang, Z.; Amarnath, I.; Waddell, L. J. N.; Batey, U. S.; Serna Daza, O.; Newling, K.; James, S.; Grogan, G.; Unsworth, W. P.; Lichman, B. R.
10.1101/2024.06.04.597157 — biochemistry — Posted on 2025-06-07
1389 Hippocampal reactivation of aversive experience enables safety learning and slow-breathing state for recovery from stress
Maheo, B.; Bagur, S.; Bryzgalov, D.; Hayhurst, C.; Chouvaeff, M.; Callas, E.; Carole, S.; Gallopin, T.; Benchenane, K.
10.1101/2025.06.03.657500 — neuroscience — Posted on 2025-06-07
1392 Cardiorespiratory mechanisms triggered during music perception in preterm infants and adults
Lavezzo, L.; Barcos-Munoz, F.; Benis, D.; Margaria, J.; Grandjean, D.; Scilingo, E. P.; Vollenweider, A.; Henriot, S.; Nardelli, M.; Hüppi, P.; Filippa, M.
10.1101/2025.06.03.657691 — physiology — Posted on 2025-06-07
1393 Proteomic characterization of major fish allergy responsive protein parvalbumins in Hilsa (Tenualosa ilisha): A commercially important fish in Southeast Asia
Shaheen, N.; Peng, Z.; Singh, A.; Wahab, A.; Gasset, M.; Islam, M. H.; Halima, O.; Ali, A. F.; Shah, S. M.; Salkini, M.; Saleemi, S.; Mallah, A. M.; Khan, A.; Mesiya, S.; Khandaker, M.; Zarif, A.; Ali, A.; Samour, A.; Peters, J. W.; Ahsan, N.; Yang, Z.
10.1101/2025.06.03.657624 — biochemistry — Posted on 2025-06-07
1395 Substructure and maturation of lamina-associated domains in neurons of the developing and adult human brain
Zhang, C.; Gil, E.; Ahanger, S. H.; Li, M.; Wang, L.; Huang, E. J.; Li, J.; Kriegstein, A. R.; Lim, D. A.
10.1101/2024.11.27.625786 — genomics — Posted on 2025-06-07
1399 Stochastic Misfolding Drives the Emergence of Distinct α-Synuclein Strains
So, R. W. L.; Frieg, B.; Camino, J. D.; Silver, N. R. G.; Mao, A.; Stuart, E.; Schröder, G. F.; Watts, J. C.
10.1101/2025.06.03.657690 — neuroscience — Posted on 2025-06-07
1400 Mapping the Transcriptional Landscape of Drug Responses in Primary Human Cells Using High-Throughput DRUG-seq
Baugh, L.; Vigneau, S.; Sridhar, S.; Boswell, S.; Pilitsis, G.; Bradley, J.; Allen, O.; Rand, L.; Riccardi, A.; Roach, K.; Lema, K.; Ergun, A.
10.1101/2025.06.03.657593 — systems biology — Posted on 2025-06-07
1401 Maize root growth, Oxygen and N availability drive formation of N2O hotspots in soil
Rummel, P. S.; Rasmussen, M. R.; Saghai, A.; Merl, T.; Hallin, S.; Mueller, C. W.; Koren, K.
10.1101/2025.06.03.657623 — plant biology — Posted on 2025-06-07
1403 Parkinson's disease-vulnerable and -resilient dopamine neurons display opposite responses to excitatory input
Hadjas, L. C.; Kollman, G. J.; Linderhof, L.; Xia, M.; Mansur, S.; Saint-Pierre, M.; Lim, B.; Lee, E. B.; Cicchetti, F.; Awatramani, R.; Hollon, N. G.; Hnasko, T. S.
10.1101/2025.06.03.657460 — neuroscience — Posted on 2025-06-07
1406 Multimodal layer-crossing interrogation of brain circuits enabled by microfluidic axialtrodes
Sui, K.; Codadu, N. K.; Rathore, D.; Li, G.; Meneghetti, M.; Bocker, A. L.; Berg, R. W.; Wykes, R. C.; Markos, C.
10.1101/2024.10.18.619110 — neuroscience — Posted on 2025-06-07
1407 Human PAR1 expressed on mouse platelets contributes to hemostasis and arterial occlusion
Kanaji, S.; Zarpellon, A.; Aiolfi, R.; Morodomi, Y.; Orje, J.; Zampolli, A.; Won, E.; Ruggeri, Z. M.; Kanaji, T.
10.1101/2025.06.03.657740 — physiology — Posted on 2025-06-07
1408 HNF4α controls growth, identity and response to KRAS inhibition of invasive mucinous adenocarcinoma of the lung
Essel Dadzie, H.; Green, Y. S.; Camolotto, S.; Gumbleton, M.; Maeda, Y.; Spike, B. T.; Snyder, E. L.
10.1101/2025.06.06.658155 — cancer biology — Posted on 2025-06-07
1409 DNA Partitioning Modulates Liquid-to-Solid Transitions and the Internal Microstructure of FUS Condensates
Ilhamsyah, D.; Luong, C.; Qamar, S.; St George-Hyslop, P.; Ju, L. A.; Mackay, J.; Knowles, T.; Vigolo, D.; Shen, Y.
10.1101/2025.06.03.657213 — biophysics — Posted on 2025-06-07
1410 Single-cell transcriptomic integrated with machine learning reveals retinal cell-specific biomarkers in diabetic retinopathy
LIN, S.; Yang, L.; TAO, Y.; PAN, Q.; CAI, T.; Ye, Y.; Liu, J.; Zhou, Y.; Shao, Y.; Yi, Q.; Lu, Z. H.; Chen, L.; McKay, G.; Rankin, R.; Li, F.; Meng, W.
10.1101/2025.06.03.657753 — bioinformatics — Posted on 2025-06-07
1413 Microbiome composition shapes temperature tolerance in a Hawaiian picture-winged Drosophila
Price, D. K.; West, K.; Cevallos-Zea, M.; Cahan, S.; Longman, E.; Nunez, J. C. B.; Yew, J.; Mederios, M. J.
10.1101/2025.06.03.657679 — evolutionary biology — Posted on 2025-06-07
1414 Lack of mRNA Methylation in Schwann Cells Results in Demyelination and Regenerative Failure
Sari, M. C.; Johnson, A.; Yu, A. T.; Mi, R.; Chen, W.; Hu, X.; Harris, T. G.; Tuffaha, S.; Swarup, V.; Kawaguchi, R.; Ming, G.-L.; Hoke, A.
10.1101/2025.06.03.657089 — neuroscience — Posted on 2025-06-07
1416 Respiratory coordination of excitability states across the human wake-sleep cycle
Sanchez Corzo, A.; Bullon Tarraso, E.; Saltafossi, M.; Berther, T.; Staudigl, T.; Kluger, D. S.; Schreiner, T.
10.1101/2025.06.03.657770 — neuroscience — Posted on 2025-06-07
1417 Impairment in axonal translation and cytoplasmic viscosity during aging in sensory neurons
Emily, M. F.; Guillaud, L.; De la Fuente Ruiz, S.; Agrawal, R.; Boerner, S.; Akimoto, Y.; Turkki, T. H.; Rosti, M. E.; Terenzio, M.
10.1101/2025.06.03.657746 — neuroscience — Posted on 2025-06-07
1419 Paracrine Signals from HIV-1 Infected Immune Cells Reprogram Cervical Cancer Pathways
Olwal, C. O.; Rathore, U.; Makanani, S.; Kaushal, P.; Ashley, I. A.; Ummadi, M. R.; Appiah, V.; Djomkam Zune, A. L.; Blanc, S.; Winters, D.; Delgado, Y.; Muthoka, K.; Fabius, J. M.; Eckhardt, M.; Kaake, R. M.; Su, M.; Fregoso, O. I.; Hultquist, J. F.; Orango, E. O.; Swaney, D. L.; Kyei, G. B.; Krogan, N. J.; Quashie, P. K.; Bediako, Y.; Bouhaddou, M.
10.1101/2025.06.06.658239 — cancer biology — Posted on 2025-06-07
1423 Examining the Role of Extrachromosomal DNA in 1,216 Lung Cancers
Khandekar, A.; Hoang, P. H.; Luebeck, J.; Diaz-Gay, M.; Zhao, W.; McElderry, J. P.; Hartman, C.; Miraftab, M.; Lee, O. W.; Barnao, K. M.; Bergstrom, E. N.; Yang, Y.; Nowak, M. A.; Rothman, N.; Homer, R.; Yang, S.-R.; Lan, Q.; Wedge, D. C.; Yang, L.; Chanock, S. J.; Zhang, T.; Alexandrov, L. B.; Landi, M. T.
10.1101/2025.06.03.657117 — bioinformatics — Posted on 2025-06-07
1426 Intraspecific variation in the duration of epigenetic inheritance
Frejacques, F.; Saglio, M.; Aljohani, M.; Froekjaer-Jensen, C.; Frezal, L.; Felix, M.-A.
10.1101/2025.06.04.657799 — evolutionary biology — Posted on 2025-06-07
1428 Heme-Mediated Selection of Encapsulated Streptococcus pneumoniae in the Lungs by Oxidative Stress
Alibayov, B.; Jop Vidal, A. G.; Murin, L.; Scasny, A.; Takeshita, K.; Beaton, K.; Edwards, K.; Punshon, T.; Jackson, B.; McDaniel, L. S.; Vidal, J. E.
10.1101/2023.11.14.567109 — microbiology — Posted on 2025-06-07
1430 Inhibiting RhoA Activation via GDP-state Stabilization to Relieve Heart Failure
Xue, M.; Liang, Y.; Yuan, Z.; Liu, X.; Chang, L.; Wang, Y.; Xu, P.; Zhang, T.; Jiang, H.; Zhao, Z.; Liu, J.; Ruan, S.; Ye, T.; Pang, X.; Mei, W.; Wang, J.; Sun, X.; Wang, H.; Cui, J.; Zu, Y.; Lin, X.; Zhao, Z.; Wang, R.; Huang, H.; Luo, C.; Tao, S.; Wang, J.; Duan, Y.; Zhu, L.; Tang, H.; Zhang, J.; Wang, Y.; Li, C.; Li, H.
10.1101/2025.06.03.657556 — pharmacology and toxicology — Posted on 2025-06-07
1431 Integrative analysis of mRNA stability regulation uncovers a metastasis-suppressive program in breast cancer
Karner, H.; Mittmann, T. C.; Chen, V. W.; Borah, A. A.; Langen, A.; Yousefi, H.; Fish, L.; Zaro, B. W.; Navickas, A.; Goodarzi, H.
10.1101/2025.06.06.658309 — cancer biology — Posted on 2025-06-07
1432 TRPV4 Channels Mediate Bladder Cancer Cell Proliferation, Migration and Chemoresistance
Katari, V.; Dalal, K.; Kondapalli, N.; Paruchuri, S.; Nadiminity, N.; Thodeti, C.
10.1101/2025.06.05.657842 — cancer biology — Posted on 2025-06-07
1433 Acid ceramidase inhibition enhances BCL-2 targeting in venetoclax-resistant acute myeloid leukemia via a cytotoxic integrated stress response
Ung, J.; Tan, S.-F.; Shaw, J. J.; Taori, M.; Deddens, T. M.; Venancio, G. d. C.; Montgomery, M. M.; Hagen, J. T.; Aruleba, R. T.; Golla, U.; Sharma, A.; Paudel, B. B.; Lee, I. S.-A.; Ramamoorthy, B.; Janes, K. A.; Garrett-Bakelman, F. E.; Cabot, M. C.; Fisher-Wellman, K. H.; Fox, T. E.; Claxton, D. F.; Chalfant, C. E.; Feith, D. J.; Loughran, T. P.
10.1101/2025.06.06.657881 — cancer biology — Posted on 2025-06-07
1434 Pancreatic cancer cachexia is mediated by PTHrP-driven disruption of adipose de novo lipogenesis
Bhalerao, N. U.; Ogoti, Y.; Peura, J.; Johnson, C.; Chen, Q.; Korobkina, E.; Keller, F.; Wengyn, M.; Norgard, R. J.; Shamber, C.; Klute, K.; DiMaio, D.; Sellin, K.; Grandgenett, P. M.; Li, R.; Hollingsworth, M. A.; GUILHERME, A.; Czech, M.; Kremer, R.; Zhu, L. J.; Watson, E. V.; Ruscetti, M.; Guertin, D.; Pitarresi, J. R.
10.1101/2025.06.03.657464 — cancer biology — Posted on 2025-06-07
1435 Dietary lipids, not ketone body metabolites, influence intestinal tumorigenesis in a ketogenic diet
Shay, J. E. S.; Chi, F.; Tzouanas, C. N.; Hoeve-Scott, J. T.; Williams, K. J.; Sever, T.; Fuentes, I.; Yilmaz, O. H.
10.1101/2025.06.06.658169 — cancer biology — Posted on 2025-06-07
1438 Multimodal profiling unveils a reversible basal-like breast cancer cell state resistant to AKT inhibition
Ratcliffe, C. D. H.; Sparks, H.; Boezio, G. L. M.; Alexandrov, Y.; Jenkins, R. P.; Le Marois, A.; Soro-Barrio, P.; Lee, R.; Strohbuecker, S.; Joshi, S.; Ellis, J. K.; Fortier, A.-M.; Gustafsson, N.; Cunha, A. C.; Park, M.; MacRae, J. I.; Serio, A.; Briscoe, J.; Riddell, A.; Barry, S. T.; Dunsby, C.; Sahai, E.
10.1101/2025.06.06.658331 — cancer biology — Posted on 2025-06-07
1439 Modeling acquired TKI resistance and effective combination therapeutic strategies in murine RET+ lung adenocarcinoma
Hinz, T. K.; Le, A. T.; Doan, T.; Ast, A.; Jaramillo, S.; Haines, S.; Navarro, A.; Patil, T.; Nemenoff, R. A.; Heasley, L. E.
10.1101/2025.06.04.657911 — cancer biology — Posted on 2025-06-07
1440 Assessing target genes for homing suppression gene drive
Xu, X.; Fang, J.; Chen, J.; Yang, J.; Yang, X.; Hou, S.; Sun, W.; Champer, J.
10.1101/2024.12.06.627146 — genetics — Posted on 2025-06-07
1442 Live-cell analyses with unsegmented images to study cancer cell response to modified T cell therapy
Epstein, L.; Weiner, A. C.; Verma, A.; Saedi, M.; Carnevale, J.; Marson, A.; Engelhardt, B. E.
10.1101/2025.06.04.657687 — cancer biology — Posted on 2025-06-07
1443 Dual inhibition of EGFR and PI3Kinase signaling in EGFR amplified triple negative breast cancer cells induces apoptosis and reduces tumor growth
Wisniewski, D. J.; Voeller, D.; Addissie, Y. A.; Deshmukh, S. K.; Wangsa, D.; Wangsa, D.; Heselmeyer-Haddad, K.; Wu, S.; Lustberg, M. B.; Sledge, G. W.; Lipkowitz, S.
10.1101/2025.06.03.657674 — cancer biology — Posted on 2025-06-07
1446 A multi-step immune-competent genetic mouse model reveals phenotypic plasticity in uveal melanoma
Xu, X.; Liu, X.; Dollar, J.; Liu, X.; Jasani, N.; Posorske, B.; Sriramareddy, S. N.; Jarajapu, V.; Kuznetsoff, J. N.; Sinard, J.; Bennett, R. L.; Licht, J.; Smalley, K.; Harbour, J. W.; Yu, X.; Karreth, F. A.
10.1101/2025.06.04.657841 — cancer biology — Posted on 2025-06-07
1448 LSH-mediated resolution of R-loops mitigates transcription-replication conflicts to preserve genomic stability in prostate cancer cells
Ni, K.; Zhang, Y.; Zheng, K.; Huang, J.; Xiong, N.; Liang, R.; Chen, Y.; Jin, H.; Hai, Y.; Li, W.; Ma, J.; Yang, R.; Xia, G.; Bai, Y.; Song, L.; Hu, X.; Tang, Z.; Fu, Q.
10.1101/2025.06.04.657812 — cancer biology — Posted on 2025-06-07
1449 Notch3 regulates pericyte phenotypic plasticity in colorectal cancer
Koliaraki, V.; Chalkidi, N.; Stavropoulou, A.; Arvaniti, V. Z.; Paraskeva, C.; Monogyiou, A.; Sakkou, M.; Nikolaou, C.
10.1101/2025.06.04.657823 — cancer biology — Posted on 2025-06-07
1450 Tumor-Educated-Platelets interact with Breast Cancer-Stem-Cells via P-selectin- PSGL1 and ensure stemness and metastasis through WNT-β-Catenin-VEGF-VEGFR2 intra-cellular signaling: Therapeutic modulation by aspirin
Guha, A.; Sultana, J.; Bhuniya, A.; Chakravarti, M.; Bera, S.; Sarkar, A.; Dhar, S.; Roy Choudhury, P.; Das, J.; Ganguly, N.; Guha, I.; Das, T.; Alam, N.; Ghosh, I.; Hajra, S.; Baral, R.; Bose, A.; Banerjee, S.
10.1101/2025.06.04.657784 — cancer biology — Posted on 2025-06-07
1451 LIMD1 Loss Confers a GPX4-Dependent Cell State in Lung Cancer
Saha, A.; Grevitt, P.; Marques, J. G.; Von Kriegsheim, A.; Shah, K. M.; Gao, Z.; Stockwell, B. R.; Finch, A. J.; Peck, B.; Sharp, T. V.
10.1101/2025.06.06.658274 — cancer biology — Posted on 2025-06-07
1455 Calcium Dependent Conformational Changes in Human Transglutaminase 2 and its Implications in Celiac Disease
Srikanth, S.; Karthikeyan, P. P.; Sezen, M.; Sridhar, D. K.; Doppalapudi, K.; Sen, T. Z.; Ulaganathan, V.; Yennamalli, R. M.
10.1101/2025.06.04.657948 — bioinformatics — Posted on 2025-06-07
1457 Loss of endothelial ALK1 signaling induces the emergence of a KIT+ angiogenic endothelial cluster driving brain arteriovenous malformations
Drape, E.; Carrier, L.; Cagnone, G.; Drissi Touzani Walali, H.; Bizou, M.; Van Vliet, P. P.; Andelfinger, G.; Larrivee, B.; Dubrac, A.
10.1101/2025.06.05.657957 — cell biology — Posted on 2025-06-07
1459 Analysis of Essential Genes in Clostridioides difficile by CRISPRi and Tn-seq
Alberts, M.; Kurtz, M.; Müh, U.; Bernardi, J.; Bollinger, K.; Duncan, L.; Dobrila, H. A.; Laster, H.; Orea, A.; Pannullo, A.; Rivera-Rosado, J.; Torres, F.; Ellermeier, C. D.; Weiss, D. S.
10.1101/2025.06.04.657922 — microbiology — Posted on 2025-06-07
1460 Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically-diverse Caenorhabditis nematodes
Banse, S. A.; Sedore, C. A.; Coleman-Hulbert, A.; Johnson, E.; Onken, B.; Hall, D.; Segerdell, E.; Jackson, E. G.; Song, Y.; Osman, H. C.; Xue, J.; Basttistoni, E.; Guo, S.; Foulger, A.; Achanta, M.; Sheikh, M.; Fitzgibbon, T.; Willis, J. H.; Woodruff, G. C.; Driscoll, M.; Lithgow, G.; Phillips, P. C.
10.1101/2024.10.23.619838 — genetics — Posted on 2025-06-07
1461 Intestinal Stem Cells from Patients with Inflammatory Bowel Disease Retain an Epigenetic Memory of Inflammation
Hamdan, F. H.; Perez, I.; Kossick, K.; Smith, H.; Edwinson, A.; de Hoyos-Vega, J. M.; Gonzalez, M.; Chiang, D.; Klatt, E.; Rumer, K.; Perez Pachon, M.; Sagstetter, M.; Friton, J.; Kammer, E.; English, A.; Chini, L. C. S.; Carnahan, J. F.; Baca, N. A.; Mopuri, R.; Bhagwate, A.; Raffals, L. E.; Sun, Z.; Grover, M.; Revzin, A.; Faubion, W. A.; Druliner, B. R.
10.1101/2025.05.24.655923 — molecular biology — Posted on 2025-06-07
1462 TICKHUNTER: A Targeted Hybridization-Capture Sequencing Approach for the Detection and Characterization of Tick-borne Pathogens and Blood Meals
Wang, X.; Brown, J. J.; Lilly, M. V.; Plimpton, L.; Murrell, C. M.; Llanos-Soto, S. G.; Zehr, J. D.; Sun, Y.; Reboul, G.; Sams, K.; Sabaawy, A.; Singh, L.; Tallmadge, R. L.; Mitchell, P. K.; Anderson, R. R.; Ladd-Wilson, S. G.; Bourgikos, E.; Vogels, C. B.; Olarte-Castillo, X. A.; Diuk-Wasser, M.; Goodman, L. B.
10.1101/2025.06.06.658355 — microbiology — Posted on 2025-06-07
1466 Stress induces distinct social behavior states encoded by the ventral hippocampus
Sattler, K. P.; Conoscenti, M. A.; Hedges, A.; Ortega, J.; Miller, R.; Owen, E.; Hanson, R.; Zelikowsky, M.
10.1101/2025.06.06.658117 — neuroscience — Posted on 2025-06-07
1467 Neural coding of spectrotemporal modulations in the auditory cortex supports speech and music categorization
Ginzburg, J.; Debaque, E. C.; Borderie, A.; Morillon, B.; Martineau, L.; Bonaventure, P. L.; Zatorre, R. J.; Albouy, P.
10.1101/2025.06.05.657930 — neuroscience — Posted on 2025-06-07
1468 Causal Lesion Evidence for Two Motor Speech Coordination Networks in the Brain
Burns, W.; Strawderman, E.; Meyers, S. P.; Schmidt, T.; Walter, K. A.; Pilcher, W. H.; Mahon, B. Z.; Garcea, F. E.
10.1101/2025.06.05.658124 — neuroscience — Posted on 2025-06-07
1469 Targeting Neutrophil Extracellular Traps to inhibit Colon Cancer Tumor Necrosis and Metastasis
Gazzara, E.; Adrover, J. M.; Lui, A.; Han, S.; Aminzada, Z.; Bhandari, N.; Sivetz, N.; Shirue, V. S.; Shergill, B. S.; Curtis, M. B.; George, S. C.; Cicala, A.; Rishi, A.; Chung, C.; Devoe, C.; Huang, H.; Weiss, M.; Lou, E.; Tuveson, D. A.; Beyaz, S.; Westcott, P. M. K.; Egeblad, M.; Gholami, S.
10.1101/2025.05.30.657122 — cancer biology — Posted on 2025-06-07
1470 Automatic Phenotyping Using Exhaustive Projection Pursuit
Moore, W. A.; Meehan, S. W.; Meehan, C.; Parks, D. R.; Walther, G.; Herzenberg, L. A.
10.1101/2024.11.20.624581 — bioinformatics — Posted on 2025-06-06
1471 The flexible stalk domain of sTREM2 modulates its interactions with brain-based phospholipids
Saeb, D.; Lietzke, E. E.; Fuchs, D. I.; Aldrich, E. C.; Bruce, K. D.; Sprenger, K. G.
10.1101/2024.09.04.611223 — bioengineering — Posted on 2025-06-07
1476 Human genetic ancestry, Mycobacterium tuberculosis diversity and tuberculosis disease severity in Dar es Salaam, Tanzania
Zwyer, M.; Xu, Z. M.; Ross, A.; Hella, J.; Sasamalo, M.; Rotival, M.; Hiza, H.; Rutaihwa, L. K.; Borrell, S.; Reither, K.; Fellay, J.; Portevin, D.; Quintana-Murci, L.; Gagneux, S.; Brites, D.
10.1101/2024.08.10.607244 — evolutionary biology — Posted on 2025-06-06
1477 Developmentally cascading structures do not lose evolutionary potential, but compound developmental instability in rat molars
Vitek, N. S.; Saks, E.; Dong, A.; Burroughs, R.; Ward, D. L.; Pomeroy, E.; Martin-Gronert, M.; Ozanne, S. E.
10.1101/2025.01.13.632740 — evolutionary biology — Posted on 2025-06-07
1478 Ancestral splice variation is a substrate for rapid diversifcation in African cichlids
Singh, P.; Ahi, E. P.; Duenser, A.; Durdevic, M.; Gessl, W.; Schaeffer, S.; Seehausen, O.; Sturmbauer, C.
10.1101/2025.05.13.653813 — evolutionary biology — Posted on 2025-06-07
1481 Short-term management of kelp forests for marine heatwaves requires planning
Hopf, J. K.; Giraldo-Ospina, A.; Caselle, J. E.; Kroeker, K. J.; Carr, M. H.; Botsford, L. W.; Hastings, A.; White, J. W.
10.1101/2025.01.30.634607 — ecology — Posted on 2025-06-07
1483 Unbiased profiling of multipotency landscapes reveals spatial modulators of clonal fate biases
Erickson, A. G.; Isaev, S.; He, J.; Artemov, A. V.; Semsch, B.; Murtazina, A.; Sun, J.; Mangold, K.; Chalou, A.; Frisen, J.; Ratz, M.; Andersson, E. R.; Kharchenko, P. V.; Adameyko, I.
10.1101/2024.11.15.623687 — developmental biology — Posted on 2025-06-06
1484 miR-133a and miR-338-3p Shape Neural Crest Derivatives in Zebrafish
Steeman, T. J.; Weiner, A. M. J.; Rubiolo, J. A.; Sanchez, L. E.; Calcaterra, N. B.
10.1101/2025.06.06.658297 — developmental biology — Posted on 2025-06-07
1485 Plat safeguards maternally aged oocytes against programmed cell death through activating the Erk1/2 pathway
He, X.; Zhang, H.; Wang, Y.; Yan, H.; Chen, Q.; Su, M.; Shi, Q.; Zeng, X.; Sheng, W.; Wang, Y.; Wang, C.; Hou, S.; Hu, Z.; He, Y.; Wang, X.
10.1101/2025.02.11.637629 — developmental biology — Posted on 2025-06-07
1489 Deep learning recognises antibiotic modes of action from brightfield images
Krentzel, D.; Kho, K.; Petit, J.; Mahtal, N.; Chiaravalli, J.; Shorte, S. L.; Wehenkel, A. M.; Boneca, I. G.; Zimmer, C.
10.1101/2025.03.30.645928 — microbiology — Posted on 2025-06-07
1490 NEUROLINGUA: A Neuroimaging Database Tailored to Unravel the Complexity of Multilingual Comprehension
Quinones, I.; Carrion-Castillo, A.; Diez-Zabala, I.; de Frutos-Sagastuy, L.; Costello, B.; Carcedo, D.; Manso-Ortega, L.; Slivka, M.; Sanchez, A.; Schüller, A.; Caballero Gaudes, C.; Paz Alonso, P. M.; Carreiras, M.
10.1101/2025.06.06.658050 — neuroscience — Posted on 2025-06-06
1493 Central nervous system atlas of larval zebrafish constructed using the morphology of single excitatory and inhibitory neurons
Du, X.; Yue, Z.; Wei, J.; Li, W.; Chen, M.; Chen, T.; Hu, H.; Ren, H.; Jia, Z.; Ning, X.; Zhong, Y.; Zheng, X.; Wang, R.; Wan, H.; Zhao, T.; Jin, C.; Huang, J.; Shen, X.; Zheng, M.; Shen, X.; Qiu, X.; Zhang, W.; Zhao, Q.; Ma, Y.; Li, D.; Chen, L.; Wang, Y.; Wang, S.; Gong, Y.; Mu, Y.; Ji, P.; He, J.; Wang, Y.; Du, J.
10.1101/2025.06.06.658008 — neuroscience — Posted on 2025-06-06
1495 Synthetic Serum Markers Enable Noninvasive Monitoring of Gene Expression in Primate Brains
Lee, S.; Romac, M.; Watanabe, S.; Chernov, M.; Li, H.; Raisley, E.; Szablowski, J. O.; Costa, V. D.
10.1101/2025.06.01.657212 — neuroscience — Posted on 2025-06-06
1496 Convergent and divergent brain-cognition relationships during development revealed by cross-sectional and longitudinal analyses in the ABCD Study
Yeo, T.; Xie, Y.; Zhang, S.; Orban, C.; Ooi, L. Q. R.; Kong, R.; Floris, D. L.; Zuo, X.-N.; Dhamala, E.; Holmes, A. J.; Uddin, L. Q.; Nichols, T. E.; Di Martino, A.
10.1101/2025.06.06.658294 — neuroscience — Posted on 2025-06-07
1498 Cell-Cell Communication and Gene Regulation of Stem Cell-Parenchymal Cell Fusion
Nazaryabrbekoh, F.; Huang, J.; Shoaib, S. S.; Tang, X.; Kim, J.; Ogle, B. M.; Jung, J. P.
10.1101/2025.02.11.637745 — systems biology — Posted on 2025-06-06
1499 Protein phase change batteries drive innate immune signaling and cell fate
Rodriguez Gama, A.; Miller, T.; Venkatesan, S.; Lange, J. J.; Wu, J.; Song, X.; Bradford, W. D.; Cook, M.; Unruh, J. R.; Halfmann, R.
10.1101/2023.03.20.533581 — biophysics — Posted on 2025-06-06
1502 Dynamic strategic social learning in nest-building zebra finches and its generalisability
Breen, A. J.; Eckersley, T.; Camacho-Alpizar, A.; Lambert, C. T.; Balasubramanian, G.; Healy, S. D.; McElreath, R.; Guillette, L. M.
10.1101/2025.06.06.658225 — animal behavior and cognition — Posted on 2025-06-06
1504 Substructure and maturation of lamina-associated domains in neurons of the developing and adult human brain
Zhang, C.; Gil, E.; Ahanger, S. H.; Li, M.; Wang, L.; Huang, E. J.; Li, J.; Kriegstein, A. R.; Lim, D. A.
10.1101/2024.11.27.625786 — genomics — Posted on 2025-06-06
1506 Single-nucleus RNA sequencing reveals the cellular diversity of cerebrospinal fluid in the context of intraventricular hemorrhage
Malaiya, S.; Serra, R.; Cortes-Gutierrez, M.; Wilhelmy, B. E.; Jusuf, E.; Somalinga, M.; Peprah, D.; Nambiar, H.; Kim, K. T.; Saadon, J. R.; Patel, P. D.; Yarmoska, S. K.; Rakovec, M.; Kim, J.; Lei, C.; Panchagnula, S.; Ambrocio, R. E.; Cherney, M.; Ayithan, N.; Fan, X.; Gerzanich, V.; Simard, J. M.; Badjatia, N.; Schwartzbauer, G.; Parikh, G. Y.; Ament, S. A.; Ciryam, P.
10.1101/2025.06.05.657834 — genomics — Posted on 2025-06-06
1508 Phosphatidylethanolamine is a phagocytic ligand implicated in the binding and removal of apoptotic and microbial extracellular vesicles
Kavianpour, A.; Ghasempour, S.; Meyer, K. J.; Le, T.; Cai, R.; Marques, P. E.; Nodwell, J. R.; Freeman, S. A.
10.1101/2024.11.18.624161 — cell biology — Posted on 2025-06-06
1510 Cross-species Standardised Cortico-Subcortical Tractography
Assimopoulos, S.; Warrington, S.; Folloni, D.; Bryant, K.; Tang, W.; Jbabdi, S.; Heilbronner, S.; Mars, R. B.; Sotiropoulos, S. N.
10.1101/2025.04.29.651254 — neuroscience — Posted on 2025-06-06
1511 High frequency spike inference with particle Gibbs sampling
Diana, G.; Sermet, B. S.; DiGregorio, D. A.; Wang, S. S.; Broussard, G. J.
10.1101/2022.04.05.487201 — neuroscience — Posted on 2025-06-06
1515 BetaII-Spectrin Gaps and Patches Emerge from the Patterned Assembly of the Actin/Spectrin Membrane Skeleton in Human Motor Neuron Axons
Gazal, N. G.; Castellanos-Montiel, M. J.; Bruno, G.; Franco-Flores, A. K.; Lepine, S.; Gursu, L.; Haghi, G.; Maussion, G.; Anastasia, A.; Bisbal, M.; Gorostiza, E. A.; Durcan, T. M.; Unsain, N.
10.1101/2025.05.09.653215 — neuroscience — Posted on 2025-06-06
1516 Neural Adaptation to Expected Uncertainty in Neurotypical Adults and High-Functioning Adults with Autism Spectrum Disorder
Pultsina, K.; Kozunova, G.; Chernyshev, B.; Prokofyev, A.; Tretyakova, V.; Novikov, A.; Rytikova, A.; Stroganova, T.
10.1101/2025.03.30.646160 — neuroscience — Posted on 2025-06-06
1520 Mechanisms of 10-Hydroxyoctadecanoic acid resistance in Streptococcus pneumoniae
Johnson, C.; Frank, M. W.; Morrow, B. T.; Jia, Q.; Radka, C. D.; Rosch, J. W.
10.1101/2025.06.06.658354 — microbiology — Posted on 2025-06-06
1523 A multi-partner symbiotic community inhabits the emerging pest Pentastiridius leporinus
Vogel, H.; Weiss, B.; Rama, F.; Rinklef, A.; Engl, T.; Kaltenpoth, M.; Vilcinskas, A.
10.1101/2025.06.03.657594 — systems biology — Posted on 2025-06-06
1526 Benchmarking Docking Tools on Experimental and Artificial Intelligence-Predicted Protein Structures
Tejera Nevado, P.; Junod, N.; Hyunjin Kwon, E.; Prieto Santamaria, L.; Rodriguez Gonzalez, A.
10.1101/2025.06.03.657620 — bioinformatics — Posted on 2025-06-06
1527 Targeted Computational Design of an Interleukin-7 Superkine with Enhanced Folding Efficiency and Immunotherapeutic Efficacy
Lim, S.-K.; Lin, W.-C.; Pan, Y.-C.; Huang, S.-W.; Yu, Y.-A.; Chang, C.-H.; Hu, C.-M. J.; Mou, C.-Y.; Mou, K. Y.
10.1101/2025.06.03.657627 — bioengineering — Posted on 2025-06-06
1529 Structure of the central Staphylococcus aureus AAA+ protease MecA/ClpC/ClpP
Azinas, S.; Wallden, K.; Katikaridis, P.; Jenne, T.; Schahl, A.; Mogk, A.; Carroni, M.
10.1101/2025.06.06.658286 — biochemistry — Posted on 2025-06-06
1531 Parallelization of single-molecule binding kinetic measurements via protein barcode sequencing
Hutchinson, S.; Mansour, G. H.; Rehan, A.; Pichard-Kostuch, A.; Redheuil, E.; Reed, B. D.; Griffiths, A. D.; Ribezzi-Crivellari, M.
10.1101/2025.06.05.658126 — biochemistry — Posted on 2025-06-06
1532 Single-stranded DNA binding proteins are essential components of the architectural LDB1 protein complex
Wang, X.; Aboreden, N. G.; Cai, Y.; Lam, J. C.; Henderson, K. A.; Xiang, J.; Giardine, B. M.; Hardison, R. C.; Keller, C. A.; Nagarajan, L.; Brandt, S. J.; Blobel, G. A.
10.1101/2025.06.05.658047 — genomics — Posted on 2025-06-06
1533 Integrating multi-covariate disentanglement with counterfactual analysis on synthetic data enables cell type discovery and counterfactual predictions.
Megas, S.; Amani, A.; Rose, A.; Dufva, O.; Shamsaie, K.; Asadollahzadeh, H.; Polanski, K.; Haniffa, M.; Teichmann, S. A.; Lotfollahi, M.
10.1101/2025.06.03.657578 — genomics — Posted on 2025-06-06
1534 Non-invasive measures of DNA methylation capture molecular aging in wild capuchin monkeys
Sadoughi, B.; Hernandez-Rojas, R.; Hamou, H.; Lopez, R.; Mah, M.; Slikas, E.; Simmons, S. M.; Orkin, J. D.; Higham, J. P.; Brosnan, S. F.; Jack, K. M.; Campos, F. A.; Snyder-Mackler, N.; Melin, A. D.
10.1101/2025.06.03.657357 — genomics — Posted on 2025-06-06
1535 The CYP71A, NIT, AMI, and IAMH gene families are dispensable for indole-3-acetaldoxime-mediated auxin biosynthesis in Arabidopsis
Fenech, M.; Brumos, J.; Pencik, A.; Edwards, B.; Belcapo, S.; DeLacey, J.; Patel, A.; Kater, M. M.; Li, X.; Ljung, K.; Novak, O.; Alonso, J. M.; Stepanova, A. N.
10.1101/2025.06.03.657619 — genetics — Posted on 2025-06-06
1538 Negative epistasis limits current codon optimization approaches
Geees, M.; Raguz Nakic, Z.; Anisimova, M.; Garcia, V.; Peters, C.
10.1101/2025.06.03.657573 — molecular biology — Posted on 2025-06-06
1539 Dietary fibre promotes chronic whipworm infection through direct and time-dependent modulation of innate immunity
Myhill, L. J.; Jensen, P.; Arora, P.; Jensen, A. M.; Zhu, L.; Vedsted-Jakobsen, A.; Thormar, E. A.; von Munchow, A.; Poojary, M. M.; Lund, M. N.; Thamsborg, S. M.; Limborg, M. T.; Jensen, B. A. H.; Williams, A. R.
10.1101/2025.06.06.658267 — microbiology — Posted on 2025-06-06
1540 Post-sampling degradation of viral RNA in wastewater impacts the quality of PCR-based concentration estimates
Munday, J. D.; de Korne-Elenbaas, J.; Gan, C.; Lison, A.; Riou, J.; Ort, C.; Julian, T. R.; Stadler, T.
10.1101/2025.06.06.658243 — microbiology — Posted on 2025-06-06
1541 3'UTR-derived small RNA couples acid resistance to metabolic reprogramming of Salmonella within macrophages
Kanda, T.; Liu, F.; Kooshapour, H.; Reichardt, S.; Wang, M.; Icyishaka, P.; Obana, N.; Westermann, A. J.; Chao, Y.; Miyakoshi, M.
10.1101/2025.06.06.658255 — microbiology — Posted on 2025-06-06
1543 AlphaFold models of host-pathogen interactions elucidate the prevalence and structural modes of molecular mimicry
Baptista, D.; Gomez-Lucas, L.; Jänes, J.; Krogan, N. J.; Joao Amorim, M.; Ivarsson, Y.; Beltrao, P.
10.1101/2025.06.04.657796 — bioinformatics — Posted on 2025-06-06
1551 The HIV-1 envelope cytoplasmic tail protects infected cells from ADCC by downregulating CD4
Tauzin, A.; Belanger, E.; Prevost, J.; Medjahed, H.; Bourassa, C.; Bibollet-Ruche, F.; Richard, J.; Hahn, B. H.; Finzi, A.
10.1101/2025.06.06.658250 — microbiology — Posted on 2025-06-06
1552 Unraveling the prevalence and multifaceted roles of accessory peptide deformylases in bacterial adaptation and resistance
Lamberioux, M.; Ducos-Galand, M.; Kaminski, P.-A.; Littner, E.; Betton, J.-M.; Mechaly, A.; Haouz, A.; Mazel, D.
10.1101/2025.06.06.657839 — microbiology — Posted on 2025-06-06
1554 Influenza A virus polymerase co-opts distinct sets of host proteins for RNA transcription or replication
Rasmussen, A. B.; Swann, O. C.; Sukhova, K.; Liu, N.; Brown, M. D.; Martin-Sancho, L.; Sheppard, C. M.; Barclay, W. S.
10.1101/2025.06.06.658254 — microbiology — Posted on 2025-06-06
1557 Bacterial peptide deformylase inhibitors induce prophages in competitors
Chen, J.; Pfeifer, K.; Steensen, K.; Crooke, A. M.; Wolfram, M.; Bobonis, J.; Lopatina, A.; Bartlau, N.; Hussain, F. A.; Balskus, E. P.; Polz, M. F.; Blainey, P. C.
10.1101/2025.06.06.656871 — microbiology — Posted on 2025-06-06
1558 Uncovering differences in rye and wheat degradation by human gut microbiota applying a quantitative multi-metaOmics in vitro approach
Hartung, C. B.; Kelder, A.; Woltemate, S.; Geffers, R.; von Felde, A.; Bach Knudsen, K. E.; Visscher, C.; Vital, M.
10.1101/2025.06.06.658233 — microbiology — Posted on 2025-06-06
1559 A Combined Chemo-Enzymatic Treatment for the Oxidation of Epoxy-Based Carbon Fiber-Reinforced Polymers (CFRPs)
Wongwattanarat, S.; Schorn, A.; Klose, L.; Carre, C.; Malvis Romero, A.; Liese, A.; Perez-Garcia, P.; Streit, W. R.
10.1101/2025.06.04.657587 — biochemistry — Posted on 2025-06-06
1560 Comparative genomics-driven design of virus-delivered short RNA inserts triggering robust gene silencing
Garcia, A.; Aragones, V.; Gioiosa, S.; Herraiz, F. J.; Ortiz-Garcia, P.; Prohens, J.; Daros, J.-A.; Pasin, F.
10.1101/2025.06.03.657697 — plant biology — Posted on 2025-06-06
1561 Gene-embedding-based prediction and functional evaluation of perturbation expression responses with PRESAGE
Littman, R.; Levine, J.; Maleki, S.; Lee, Y.; Ermakov, V.; Qiu, L.; Wu, A.; Huang, K.; Lopez, R.; Scalia, G.; Biancalani, T.; Richmond, D.; Regev, A.; Hütter, J.-C.
10.1101/2025.06.03.657653 — bioinformatics — Posted on 2025-06-06
1564 Three novel genomes broaden the wild side of the Capsicum pangenome
Papastolopoulou, C.; Nieuwenhuis, R.; Warris, S.; Bakker, L. V.; van Haarst, J.; Cordewener, J.; Hesselink, T.; van den Broeck, H. C.; van Dooijeweert, W.; de Jong, H.; Chunwongse, J.; Diaz Trivino, S.; Schijlen, E.; de Ridder, D.; Smit, S.; Peters, S.
10.1101/2025.06.03.657591 — genomics — Posted on 2025-06-06
1565 Improved genome assembly of double haploid Prunus persica siblings Lovell 2D and Lovell 5D and the peach NLRome
Gottschalk, C.; Brock, j. R.; Mansfeld, B. N.; Main, D.; Jung, S.; Zheng, P.; Vann, C.; Demuth, M.; Bennett, D.; Liu, Z.; Dardick, C.
10.1101/2025.06.03.657495 — genomics — Posted on 2025-06-06
1566 Drivers of genetic diversity across the marine tree of life
Toczydlowski, R. H.; Brennan, R. S.; Crandall, E. D.; Kelley, J. L.; Pringle, J. M.; Riginos, C.; Wares, J. P.; Bradburd, G. S.
10.1101/2025.06.03.657718 — evolutionary biology — Posted on 2025-06-06
1568 Selective breeding enhances coral heat tolerance even over small spatial scales
Kler-Lago, A.; Kiefer, K.; Strader, M.; Baptista Nobre, T.; Hendricks, S.; Richter, C.; Wild, C.; Quigley, K.
10.1101/2025.06.04.657771 — ecology — Posted on 2025-06-06
1569 An optimized rabies vaccine vehicle for orotopical administration to wild vampire bats.
Knuese, C.; Cardenas-Canales, E. M.; McDevitt-Galles, T.; Ramirez-Martinez, M. M.; Limonta, D.; Powers, L. E.; Walsh, D. P.; Streicker, D. G.; Osorio, J. E.; Zamanian, M.; Rocke, T. E.
10.1101/2025.06.03.657068 — ecology — Posted on 2025-06-06
1571 Spatially organized inflammatory myeloid-CD8+ T cell aggregates linked to Merkel-cell Polyomavirus driven Reorganization of the Tumor Microenvironment
Haist, M.; Matusiak, M.; Tan, Y.; Zimmer, S.; Stege, H.; Kempchen, T. N.; Mitschke, S.; Chu, P.; Weidenthaler-Barth, B.; Barlow, G. L.; Rogall, F.; Delgado Gonzalez, A.; Baertsch, M. A.; Albertini, S.; Gariglio, M.; Borgogna, C.; Goltsev, Y.; Grabbe, S.; Hickey, J. W.; Nolan, G. P.
10.1101/2025.06.06.657162 — immunology — Posted on 2025-06-06
1572 Enhancing protective efficacy and immunogenicity of hemagglutinin-based influenza vaccine utilizing adjuvants developed by BECC
Das, S.; Tenaglia, B. M.; Riley, D.; Speed, S.; Baracco, L.; Gardner, F. M.; Varisco, D. J.; Yang, H.; Nijhuis, H.; Kerstetter, L.; Krammer, F.; Sun, W.; Frieman, M. B.; Ernst, R. K.
10.1101/2025.06.03.657703 — immunology — Posted on 2025-06-06
1573 Gene therapies alleviate absence epilepsy associated with Scn2a deficiency in DBA/2J mice
Zhang, Z.; Zhang, J.; Chen, X.; Deming, B. A.; Kant, S.; Mandal, P.; Kothandaraman, H.; SanMiguel, P. J.; Halurkar, M. S.; Abeyaratna, A. D.; Robinson, M. J.; Zhao, Y.; Vitko, Y.; Gaykema, R. P.; Yuan, C.; Lanman, N. A.; Tegtmeyer, M. T.; Wang, D.; Gao, G.; Shi, R.; Perez-Reyes, E.; Yang, Y.
10.1101/2025.06.03.657652 — neuroscience — Posted on 2025-06-06
1574 Intermingled representation of oral cavity in mouse trigeminal ganglion
Matunis, A.; Iwamoto, R.; Stacy, E.; Abe, K.; Tamura, S.; Kambe, Y.; Itokazu, T.; Hikida, T.; Sato, T.; Sato, T.
10.1101/2025.06.03.657656 — neuroscience — Posted on 2025-06-06
1575 Implantable CMOS Deep-Brain Fluorescence Imager with Single-Neuron Resolution
Yilmaz, S.; Choi, J.; Uguz, I.; Kim, J.; Akrouh, A.; Taal, A. J.; Andino-Pavlovsky, V.; Yin, H.; Fabbri, J. D.; Moreaux, L.; Roukes, M. L.; Shepard, K. L.
10.1101/2025.06.03.657675 — neuroscience — Posted on 2025-06-06
1577 PP2A METHYLESTERASE, PME-1, AND PP2A METHYLTRANSFERASE, LCMT-1, CONTROL SENSITIVITY TO IMPAIRMENTS CAUSED BY INJURY-RELATED OLIGOMERIC TAU
Sundaresh, S. N.; Vogel, E. W.; Hue, C. D.; Zhang, H.; Staniszewski, A.; Berman, H. L.; Gill, Z.; Asam, K.; Liang, S.; Shen, L.; Gnanaprakash, M.; Acquarone, E.; Fa, M.; Kanaan, N. M.; Morrison, B.; Arancio, O.; Nicholls, R. E.
10.1101/2025.06.05.657660 — neuroscience — Posted on 2025-06-06
1581 Genome-Wide Discovery and Characterization of Terpene Synthases Contributing to Strawberry Aroma Metabolism
Madera, M. M.; Becker, K. L.; Weissman, J. D.; Famula, R. A.; Bjornson, M.; Cole, G. S.; Feldmann, M. J.; Knapp, S. J.; Zerbe, P.
10.1101/2025.06.03.654341 — plant biology — Posted on 2025-06-06
1582 Microneedle-based precision payload delivery in plants
Li, M.; Poonam, A. D.; Singh, D.; Whitfield, A. E.; Wei, Q.
10.1101/2025.06.04.657704 — plant biology — Posted on 2025-06-06
1583 Double knockout of rice OsVIT1 and OsVIT2 genes reveals a trade-off between iron biofortification and iron excess tolerance
Benato, B. D.; Rativa, A. G. S.; Olsson, R. V.; Lima-Melo, Y.; Santos, E.; Montanha, G. S.; Alves, J. d. S.; Ponte, L. R.; Fiorentini, V. H. R.; Betin, F. M. M.; Ortolan, F.; Marques, J. P. R.; Sperotto, R. A.; Pereira de Carvalho, H. W. W. P.; Cesco, S.; Mimmo, T.; Tiziani, R.; Beone, G. M.; Navarro, N.; Roschzttardtz, H.; Perez, C. A.; Giehl, R. F. H.; Margis-Pinheiro, M.; Maraschin, F. d. S.; Ricachenevsky, F. K.
10.1101/2025.06.04.657710 — plant biology — Posted on 2025-06-06
1586 Lactate cannot replace glucose for maintaining the viability of mouse and human glioma cells
Miller, E. Y.; Duraj, T.; Ta, N. L.; Lee, D. C.; Mukherjee, P.; Shaver, O.; Seyfried, T. N.
10.1101/2025.06.03.655413 — cancer biology — Posted on 2025-06-06
1588 TORCphysics: A physical model of DNA-topology-controlled gene expression
Velasco Berrelleza, V. M.; Faulkner Rainford, P.; Mogre, A.; Benham, C. J.; Dorman, C. J.; Kroger, C.; Stepney, S.; Harris, S. A.
10.1101/2025.06.04.656888 — biophysics — Posted on 2025-06-06
1592 A Self-Supervised Foundation Model for Robust and Generalizable Representation Learning in STED Microscopy
Bilodeau, A.; Beaupre, F.; Chabbert, J.; Bellavance, J.-M.; Lessard, K.; Deschenes, A.; Bernatchez, R.; De Koninck, P.; Gagne, C.; Lavoie-Cardinal, F.
10.1101/2025.06.06.656993 — bioinformatics — Posted on 2025-06-06
1594 Ultrasensitive quantitative protein detection using Eu-ion doped vanadate nanoparticles
Kuhner, R.; Cardone, C.; Perrella, R.; Mousseau, F.; Mohammedi, R.; Sintes, J.-M.; Bourgeois, C.; Lambotte, O.; Gacoin, T.; Bouzigues, C. I.; Alexandrou, A.
10.1101/2025.06.03.657629 — bioengineering — Posted on 2025-06-06
1598 A progressive ratio task with costly resets reveals adaptive effort-delay tradeoffs
Rivera, Z. M. G.; Guerrero Leon, K.; Cervera, M.; Aguayo, B.; Izquierdo, A.; Wikenheiser, A. M.
10.1101/2025.06.03.657635 — animal behavior and cognition — Posted on 2025-06-06
1601 Vascular smooth muscle cell atherosclerosis trajectories characterized at single cell resolution identify causal transcriptomic and epigenomic mechanisms of disease risk
Li, D. Y.; Kundu, S.; Cheng, P.; Gu, W.; Jackson, W. R.; Zhao, Q.; Nguyen, T.; Worssam, M.; Monteiro, J. P.; Caceres, R. D.; Dale, S.; Palmisano, B.; Weldy, C. S.; Kundu, R.; Wirka, R. C.; Quertermous, T.
10.1101/2025.06.04.655863 — genomics — Posted on 2025-06-06
1604 Phylogenetically-informed crayfish conservation in the face of climate change
Pipins, S.; Bohm, M.; Bland, L.; Crandall, K. A.; Hossain, M. A.; Rosindell, J.; Gumbs, R.
10.1101/2025.06.03.657651 — ecology — Posted on 2025-06-06
1609 The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome
Shemtov, S. J.; McGann, E.; Carrillo, L.; Lee, S.; Anson, H.; Chung, C. S.; Anagnostou, M.-E.; Lai, G.-J. D.; Verheijen, B. M.; Wan, J.; Vorobyova, I.; Sanchez-Contreras, M.; Conover, C. A.; Thorwald, M. A.; Cohen, P.; Kennedy, S. R.; Gout, J.-F.; Haroon, S.; Vermulst, M.
10.1101/2025.06.03.656903 — molecular biology — Posted on 2025-06-06
1611 Metabolic controls on the carbon isotope fractionations of bacterial fermentation
Mueller, E.; Heuer, V. B.; Leadbetter, J. R.; Hinrichs, K.-U.; Sessions, A. L.
10.1101/2025.06.06.655161 — microbiology — Posted on 2025-06-06
1614 Pangenome-aware DeepVariant
Asri, M.; Chang, P.-C.; Mier, J. C.; Siren, J.; Eskandar, P.; Kolesnikov, A.; Cook, D. E.; Brambrink, L.; Hickey, G.; Novak, A. M.; Dorfman, L.; Webster, D. R.; Carroll, A.; Paten, B.; Shafin, K.
10.1101/2025.06.05.657102 — bioinformatics — Posted on 2025-06-06
1615 Whole chloroplast genomes reveal a complex genetic legacy of lost lineages, past radiations and secondary contacts in the dominant temperate deciduous tree genus Fagus
Worth, J. R. P.; Grimm, G. W.; Ihara-Udino, T.; Li, P.; Papageorgiou, A. C.; Simeone, M. C.; Shanjani, P. S.; Lopez-Saez, J. A.; Chiang, Y.-C.; Kitamura, K.; Tomaru, N.; Denk, T.
10.1101/2025.06.03.653586 — evolutionary biology — Posted on 2025-06-06
1616 Early neuronal reprogramming and cell cycle reentry shape Alzheimer's disease progression
Meir, R.; Schwartz, G.; Adam, M.; Avni Lapidot, A.; Cain, A.; Green, G. S.; Menon, V.; Bennett, D. A.; De Jager, P.; Habib, N.
10.1101/2025.06.04.653670 — neuroscience — Posted on 2025-06-06
1619 Spatial and single-cell transcriptomics capture two distinct cell states in plant immunity
Hu, Y.; Schaefer, R.; Rendleman, M.; Slattery, A.; Cramer, A.; Nahiyan, A.; Breitweiser, L.; Shah, M.; Kaehler, E.; Yao, C.; Bowling, A.; Crow, J.; May, G.; Tabor, G.; Thatcher, S.; Uppalapati, S. R.; Muppirala, U.; Deschamps, S.
10.1101/2025.06.03.657683 — plant biology — Posted on 2025-06-06
1622 Cooperation between a root fungal endophyte and host-derived coumarin scopoletin mediates Arabidopsis iron nutrition
Van Dijck, L.; Esposto, D.; Huelsmann, C.; Malisic, M.; Piro, A.; Giehl, R. F. H.; Balcke, G. U.; Tissier, A.; Parker, J. E.
10.1101/2025.06.04.657782 — plant biology — Posted on 2025-06-06
1623 Redesigning petal shape, size, and color in soybean reveals unexpected phenotypes for floral organ development
Szeluga, N.; AlBader, N.; Pelletier, S.; Weis, K.; Johnson, A.; Fahlgren, N.; Neequaye, M.; Vogt, G.; DelPercio, R.; Baldrich, P.; Byers, K. J. R. P.; Meyers, B. C.; Frank, M.
10.1101/2025.06.05.657847 — plant biology — Posted on 2025-06-06
1624 Accurately Programming Complex Light Regimes with Multi-channel LEDs
Vong, G. Y. W.; Scott, P.; Claydon, W.; Daff, J.; Denby, K.; Ezer, D.
10.1101/2025.06.06.658293 — plant biology — Posted on 2025-06-06
1625 FLOE1 maintains cellular viscosity in rehydrating Arabidopsis embryos
Field, S.; Ramirez, J. F.; Dorone, Y.; Cox, J. A.; Boothby, T. C.; Rhee, S. Y.
10.1101/2025.06.03.657678 — plant biology — Posted on 2025-06-06
1626 Unraveling the cis-regulatory code controlling abscisic acid-dependent gene expression in Arabidopsis using deep learning
Opdebeeck, H.; Smet, D.; Thierens, S.; Minne, M.; De Beukelaer, H.; Zuallaert, J.; Van Bel, M.; Van Montagu, M.; Degroeve, S.; De Rybel, B.; Vandepoele, K.
10.1101/2025.06.03.657584 — plant biology — Posted on 2025-06-06
1631 Statin-dye conjugates for selective targeting of KRAS mutant cancer cells
Moon, H.-r.; Cai, Z.; Cho, B. K.; Chang, H.; Hong, S. T.; Zhao, J. J.; Kwon, I. C.; Roberts, T. M.; Han, B.; Ryu, J. H.
10.1101/2025.06.03.657329 — cancer biology — Posted on 2025-06-06
1635 Postnatal Pulmonary Artery Development from Transcript to Tissue
Schwarz, E. L.; Ramachandra, A. B.; Yeung, N.; Manning, E. P.; Weiss, D.; Humphrey, J. D.
10.1101/2025.06.03.657639 — bioengineering — Posted on 2025-06-06
1639 Antigen-specific Th17 T cells offset the age-related decline in durable T cell immunity
Sturmlechner, I.; Jain, A.; Jiang, J.; Okuyama, H.; Mu, Y.; Own, M.; Weyand, C.; Goronzy, J.
10.1101/2025.06.05.658069 — immunology — Posted on 2025-06-06
1640 Spatial transcriptomic analysis of muscle biopsy from treatment-naive juvenile dermatomyositis patients reveals mitochondrial abnormalities despite disease-related interferon driven signature
Syntakas, A. E.; Kartawinata, M.; Evans, N. M. L.; Nguyen, H. D.; Papadopoulou, C.; Al Obaidi, M.; Pilkington, C.; Glackin, Y.; Mahony, C. B.; Croft, A. P.; Eaton, S.; Cortina-Borja, M.; Ogunbiyi, O.; Merve, A.; Wedderburn, L. R.; Wilkinson, M. G. L.; UK JDM Cohort and Biomarker Study (JDCBS),
10.1101/2025.06.03.657601 — immunology — Posted on 2025-06-06
1641 Synthetic Serum Markers Enable Noninvasive Monitoring of Gene Expression in Primate Brains
Lee, S.; Romac, M.; Watanabe, S.; Chernov, M.; Li, H.; Raisley, E.; Szablowski, J. O.; Costa, V. D.
10.1101/2025.06.01.657212 — neuroscience — Posted on 2025-06-06
1642 A discontinuity in motion perception during fixational drift
D'Angelo, J. C.; Tiruveedhula, P.; Weber, R. J.; Arathorn, D. W.; Otero-Millan, J.; Roorda, A.
10.1101/2025.06.02.657265 — neuroscience — Posted on 2025-06-06
1644 GPX4 Promotes Optic Nerve Regeneration and RGC Neuroprotection
Yang, M.; Bian, F.; Feng, X.; Li, L.; Huang, H.; Liu, L.; Dalal, R.; Yang, H.; Suraparaju, P. V.; Cao, F.; Ong, P.; Luo, A.; Liu, D.; Hu, Y.
10.1101/2025.06.03.657677 — neuroscience — Posted on 2025-06-06
1647 Heterogeneity in human brain clearance adds resilience against tauopathy -- a computational model informed by glymphatic MRI
Brennan, G. S.; Thompson, T. B.; Oliveri, H.; Vinje, V.; Ringstad, G.; Eide, P. K.; Goriely, A.; Rognes, M. E.
10.1101/2025.06.03.657596 — neuroscience — Posted on 2025-06-06
1651 Extracting Reproducible Components from Electroencephalographic Responses to Transcranial Magnetic Stimulation with Group Task-Related Component Analysis
Couto, B. A. N.; Fecchio, M. N.; Russo, S.; De Martino, E.; Parmigiani, S.; Sarasso, S.; Graven-Nielsen, T.; de Andrade, D. C.; Massimini, M.; Rosanova, M.; Casali, A. G.
10.1101/2025.06.02.657489 — neuroscience — Posted on 2025-06-06
1654 The Neurofibrillary Tangle Maturity Scale: A Novel Framework for Tangle Pathology Evaluation in Alzheimer's Disease
Moloney, C. M.; Rutledge, M. H.; Labuzan, S. A.; Peng, Z.; Tranovich, J. F.; Wood, A. C.; Rothberg, D. M.; Duara, R.; Lachner, C.; Graff-Radford, N. R.; Dickson, D. W.; Kanaan, N. M.; Carter, R. E.; Murray, M. E.
10.1101/2025.06.02.657435 — neuroscience — Posted on 2025-06-06
1659 Uncovering the invisible giant: Amyloid β plaques and their proposed association with waste removal in Alzheimer-affected human hippocampus
Fabian-Fine, R.; Roman, A. G.; Winters, M. J.; Lathram, K. J.; Bennett, C. H.; Kipingi, L. K.; Braennare-Gran, S. M.; Whitley, A. E.; Paul, C. M.; Altman, L. M.; Carrillo, I. C.; Joyce, F. M.; Kragh, L. A.; McKnight, T. J.; Reding, C. J.; Reiderer, L. J.; Rivera, L. J.; Steen, H. A.; Weaver, A. L.
10.1101/2025.06.01.657219 — neuroscience — Posted on 2025-06-06
1661 An improved model for prediction of de novo designed proteins with diverse geometries
Orr, B.; Crilly, S. E.; Akpinaroglu, D.; Zhu, E.; Keiser, M. J.; Kortemme, T.
10.1101/2025.06.02.657515 — bioinformatics — Posted on 2025-06-06
1663 Comparative population genomics of relictual Caribbean island Gossypium hirsutum
Ning, W.; Hu, G.; Yuan, D.; Arick, M. A.; Hsu, C.-Y.; Magbanua, Z. V.; Pechanova, O.; Peterson, D. G.; Dong, Y.; Udall, J.; Grover, C.; Wendel, J.
10.1101/2025.06.02.657498 — evolutionary biology — Posted on 2025-06-06
1664 Habitat use of juvenile green turtles along the North Pacific coast of Costa Rica
Wu, F.; Valverde-Cantillo, V.; Durr, C.; Espinoza, M.; Lowe, C.; Heidemeyer, m.; Spotila, J. R.; Paladino, F.
10.1101/2025.06.02.657549 — ecology — Posted on 2025-06-06
1666 The Impact of Coronary Artery Disease on Brain Vascular and Metabolic Health: Links to Cognitive Function
Sanami, S.; Tremblay, S. A.; Rezaei, A.; Potvin-Jutras, Z.; Sabra, D.; Intzandt, B.; Gagnon, C.; Mainville-Berthiaume, A.; Wright, L.; Gayda, M.; Iglesies-Grau, J.; Nigam, A.; Bherer, L.; Gauthier, C.
10.1101/2025.06.02.657532 — biophysics — Posted on 2025-06-06
1669 Personalized mapping of inhibitory spinal cord circuits in vivo via non-invasive neural decoding and in silico modelling
Pascual-Valdunciel, A.; Consul, N.; Brownstone, R. M.; Beato, M.; Farina, D.; Nascimento, F.; Ozyurt, M. G.
10.1101/2025.03.25.645235 — neuroscience — Posted on 2025-06-06
1674 OrganoidChip+: a Microfluidic Platform for Culturing, Staining, Immobilization, and High-Content Imaging of Adult Stem Cell-Derived Organoids
Moshksayan, K.; Khanna, R.; Camli, B.; Yakay, Z. N.; Harihara, A.; Zdyrski, C.; Mondal, S.; Hegarty, E.; Mochel, J. P.; Allenspach, K.; Ben-Yakar, A.
10.1101/2025.06.02.657499 — bioengineering — Posted on 2025-06-06
1676 Developmental dynamic transcriptomics reveals multiple effectors and transcription factors critical for Ditylenchus destructor parasitism
Dai, D.; Chen, Y.; Zhang, S.; Zhou, Y.; Wang, X.; Bo, D.; Liao, Y.; Hu, B.; Zhang, Y.; Ashry, N. M.; Peng, D.; Sun, M.
10.1101/2025.06.02.657539 — genomics — Posted on 2025-06-06
1677 Carotenoid-based immune response in sea cucumbers relies on newly identified coelomocytes -- the carotenocytes
Wambreuse, N.; Bossiroy, E.; David, F.; Vanwinge, C.; Fievez, L.; Bureau, F.; Gabriele, S.; Karasiewicz, T.; Mascolo, C.; Wattiez, R.; Eeckhaut, I.; Caulier, G.; Delroisse, J.
10.1101/2025.06.02.657395 — evolutionary biology — Posted on 2025-06-06
1678 A comparison shopper's guide to forest datasets
Lee, L. G.; Pasquarella, V. J.; Glass, B.; Morreale, L. L.; Chung, N.; Gao, X.; Thompson, J.
10.1101/2025.06.02.657445 — ecology — Posted on 2025-06-06
1681 Branched actin networks in innate immune cells mediate host microbiota homeostasis.
Vasconcellos, L. R.; Huang, S. C. M.; Suarez-Bonnet, A.; Priestnall, S.; Chakravarty, P.; Varsani-Brown, S.; Winder, M. L.; Shah, K.; Kogata, N.; Stockinger, B.; Way, M.
10.1101/2024.07.18.604111 — immunology — Posted on 2025-06-06
1682 Retinal tau phosphorylation in Alzheimer's disease: a mass spectrometry study
Santiago, J.; Poceviciute, D.; Vogel, J.; The Netherlands Brain Bank, ; Brinkmalm, G.; Wennstrom, M.
10.1101/2025.02.17.638688 — neuroscience — Posted on 2025-06-06
1683 Metabolic reprogramming and altered ATP content impair neuroprotective functions of microglia in β-glucocerebrosidase deficiency models
Brunialti, E.; Villa, A.; Szego, E. M.; La Vitola, P.; Drago, D.; Pavlovic, R.; Fontana, L.; Tuna, D.; Panzeri, A.; Meda, C.; Rondinone, O.; Pitasi, M.; Miozzo, M.; Andolfo, A.; Di Monte, D. A.; Ciana, P.
10.1101/2025.05.26.656111 — neuroscience — Posted on 2025-06-06
1685 CAN TRANSFER LEARNING IMPROVE SUPERVISED SEGMENTATIONOF WHITE MATTER BUNDLES IN GLIOMA PATIENTS?
Riccardi, C.; Ghezzi, S.; Amorosino, G.; Zigiotto, L.; Sarubbo, S.; Jovicich, J.; Avesani, P.
10.1101/2023.07.31.551318 — neuroscience — Posted on 2025-06-06
1687 BEHAV3D Tumor Profiler to map heterogeneous cancer cell behavior in the tumor microenvironment
Rios-Jimenez, E.; Zomer, A.; Collot, R.; Barrera Roman, M.; Ariese, H.; L. van Ineveld, R.; Kleinnijenhuis, M.; Bessler, N.; Johnson, H.; Dawson, C.; Rios, A.; Alieva, M.
10.1101/2024.08.23.609358 — cancer biology — Posted on 2025-06-06
1689 OriGene: A Self-Evolving Virtual Disease Biologist Automating Therapeutic Target Discovery
Zhang, Z.; Qiu, Z.; Wu, Y.; Li, S.; Wang, D.; Zhou, Z.; An, D.; Chen, Y.; Li, Y.; Wang, Y.; Ou, C.; Wang, Z.; Chen, J. X.; Zhang, B.; Hu, Y.; Zhang, W.; Wei, Z.; Ma, R.; Liu, Q.; Dong, B.; He, Y.; Feng, Q.; Bai, L.; Gao, Q.; Sun, S.; Zheng, S.
10.1101/2025.06.03.657658 — bioinformatics — Posted on 2025-06-06
1691 Development of a PEGylated Parylene Nanopocket Membrane for the Capture and Release of Lipid Vesicles
Alsudais, M.; Petersen, K.; Hosseinifakhr, A.; Frasch, L.; Gholizadeh, S.; Dehghani, M.; Gaborski, T. R.
10.1101/2025.06.02.657433 — bioengineering — Posted on 2025-06-06
1695 Possible exposure to unidentified coronaviruses in roe deer (Capreolus capreolus) populations suggested by SARS-CoV-2 serological investigation in France
Perez, G.; Lalande, L. D.; Legros, V.; Kodjo, A.; Verheyden, H.; Bourret, V.; Cebe, N.; Chaval, Y.; Revelli, P.; Pellerin, M.; Lemaitre, J.-F.; Peroz, C.; Rey, B.; Debias, F.; Garcia, R.; Bourgoin, G.; Gilot-Fromont, E.
10.1101/2025.02.19.639030 — immunology — Posted on 2025-06-06
1696 c-Myc inhibits macrophage antimycobacterial response in Mycobacterium tuberculosis infection
Sarti, E.; Dolle, C.; Wolfensberger, R.; Kusejko, K.; Russenberger, D.; Bredl, S.; Speck, R. F.; Greter, M.; Rueschoff, J. H.; Boeck, L.; Mai, D.; Diercks, A. H.; Sander, P.; Olson, G. S.; Nemeth, J.
10.1101/2025.01.09.632095 — immunology — Posted on 2025-06-06
1698 Endophytes induce systemic spatial reprogramming of metabolism in poplar roots under drought
Aufrecht, J. A.; Velickovic, D.; Tournay, R.; Couvillion, S. P.; Balasubramanian, V. K.; Winkler, T.; Herrera, D.; Stanley, R.; Doty, S.; Ahkami, A. H.
10.1101/2025.06.02.657501 — plant biology — Posted on 2025-06-06
1699 The architecture of resilience: a genome assembly of Myrothamnus flabellifolia sheds light on desiccation tolerance and sex determination
Marks, R.; Lovell, J. T.; Carey, S. B.; Van Der Pas, L.; Chimukuche, N. M.; Bruna, T.; Plott, C.; Webber, J.; Lipzen, A.; Yan, J.; Bauer, D.; Bentley, J.; Talag, J.; Barry, K.; Grimwood, J.; Jenkins, J. W.; Schmutz, J.; Harkess, A.; VanBuren, R.; Leebens-Mack, J.; Farrant, J. M.
10.1101/2025.06.02.657439 — plant biology — Posted on 2025-06-06
1700 New alleles of Arabidopsis BIK1 reinforce its predominant role in pattern-triggered immunity and caution interpretations of other reported functions
Song, B.; Choi, S.; Kong, L.; Kim, S.-I.; Fliegmann, J.; Li, X.; DeFalco, T. A.; Hu, M.; Li, M.; Zhao, Y.; Wang, H.; Shan, L.; Nuernberger, T.; He, P.; zipfel, c.; Zhou, J.-M.
10.1101/2025.06.02.657414 — plant biology — Posted on 2025-06-06
1704 A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics
Autorino, C.; Khoromskaia, D.; Harari, L.; Floris, E.; Booth, H.; Pallares-Cartes, C.; Petrasiunaite, V.; Dorrity, M.; Corominas-Murtra, B.; Hadjivasiliou, Z.; Petridou, N.
10.1101/2025.06.06.658228 — developmental biology — Posted on 2025-06-06
1705 In vivo nuclear envelope adaptation during cell migration across confining embryonic tissue environments
Haekkinen, H.-M.; Villaseca, S.; Alhashem, Z.; Chomiczewski, S.; Desevedavy, M.; Leleux, S.; Hamidzadeh, A.; Gallo, F.; El-Zohiry, D.; Petre, V. G.; Scarpa, E.
10.1101/2025.06.05.658077 — developmental biology — Posted on 2025-06-06
1706 Global profiling of the proteome and acetylome in mice with abdominal aortic aneurysms
Yang, J.; Zhang, L.; Yang, B.; Ding, T.; Zhao, Y.; Yang, Y.; Tang, X.; Wu, Y.; Wang, Q.; Zhang, Z.; Shi, C.; Han, R.; Zhang, X.; Liu, J.
10.1101/2025.06.02.657536 — bioinformatics — Posted on 2025-06-06
1711 Cardiac fibroblasts counterbalance cardiomyocytes in LMNA cardiomyopathy pathogenesis
Sikder, K.; Phillips, E.; Bouhrira, N.; Mothy, D.; Wang, N.; Bonne, G.; Margulies, K. B.; Choi, J. C.
10.1101/2025.06.05.657412 — cell biology — Posted on 2025-06-06
1712 Wolbachia induces host cell identity changes and determines symbiotic fate in Drosophila
Jacobs, J.; Mirchandani, C. D.; Seligmann, W. E.; Sacco, S.; Escalona, M.; Green, R. E.; Russell, S.
10.1101/2025.06.05.658111 — cell biology — Posted on 2025-06-06
1714 ezscore-f: A Set of Freely Available, Validated Sleep Stage Classifiers for Forehead EEG
Coon, W. G.; Zerr, P.; Milsap, G.; Sikder, N.; Smith, M.; Dresler, M.; Reid, M.
10.1101/2025.06.02.657451 — neuroscience — Posted on 2025-06-06
1717 Modelling medulloblastoma pathogenesis and treatment in human cerebellar organoids.
Willott, T. O.; Nicholson, J. G.; Xiao, Y.; Ogunbiyi, O. K.; Draper, B.; Mistry, T.; Donovan, L.; Zabet, N. R.; Merve, A.; Badodi, S.; Marino, S.
10.1101/2024.08.14.607977 — cancer biology — Posted on 2025-06-06
1719 A photostable genetically encoded voltage indicator for imaging neural activities in tissue and live animals
Cao, C.; Zhu, R.; Zhou, S.; Zhao, Z.; Lin, C.; Liu, S.; Peng, L.; Subach, F. V.; Piatkevich, K. D.; Zou, P.
10.1101/2025.05.29.656768 — bioengineering — Posted on 2025-06-06
1721 A high-quality reference genome for the Ural Owl (Strix uralensis) enables investigations of cell cultures as a genomic resource for endangered species
Chrysostomakis, I.; Mozer, A.; Bruno Di-Nizo, C.; Fischer, D.; Sargheini, N.; von der Mark, L.; Huettel, B.; Astrin, J. J.; Toepfer, T.; Boehne, A.
10.1101/2025.01.22.633903 — genomics — Posted on 2025-06-06
1722 Comprehensive molecular impact mapping of common and rare variants at GWAS loci
Balderson, B.; Tule, S.; Okino, M.-L.; Rieger, W. J.; Corban, S.; Jaureguy, J.; Palpant, N.; Gaulton, K. J.; Boden, M.; McVicker, G.
10.1101/2025.06.05.658079 — genetics — Posted on 2025-06-06
1723 Complex genetic determinism of male-fertility restoration in the gynodioecious snail Physa acuta
Skarlou, E.; Laugier, F.; Bethune, K.; Chenin, T.; Donnay, J.-M.; Froissard, C.; David, P.
10.1101/2024.08.08.607164 — evolutionary biology — Posted on 2025-06-06
1725 A distinct phase of cyclin B (Cdc13) nuclear export at mitotic entry in S. pombe
Chethan, S. G.; Rogers, J. M.; Vijayakumari, D.; Williams, W.; Gligorovski, V.; Rahi, S. J.; Hauf, S.
10.1101/2025.06.05.658100 — cell biology — Posted on 2025-06-06
1728 A single factor for safer cellular rejuvenation
de Lima Camillo, L. P.; Gam, R.; Maskalenka, K.; LeBlanc, F. J.; Urrutia, G. A.; Mejia, G. M.; Miller, H. E.; Wardlaw, C. P.; Pickles, A.; Everton, L.; Zaksauskaite, R.; Khan, R. B.; Welsh, A.; Gambo, S.; Gallardo, S.; Oliynyk, Z.; Varankar, S. S.; Epstein, A. E.; Bendall, A.; Mowatt, J.; Ives, D.; Swain, B. M.
10.1101/2025.06.05.657370 — cell biology — Posted on 2025-06-06
1731 Phage intervention improves colitis and response to corticosteroids by attenuating virulence of Crohn's disease-associated bacteria
Jackson, K.; Galipeau, H.; Hann, A.; Constante, M.; Zangara, M.; Bording-Jorgensen, M.; Fuentes, A.; Ho, H.; Wang, J.; Shimbori, C.; Moayyedi, P.; Surette, M. G.; Bercik, P.; Coombes, B.; Hosseinidoust, Z.; Verdu, E. F.
10.1101/2025.06.05.658057 — microbiology — Posted on 2025-06-06
1733 Unipolar polysaccharide-mediated attachment of the N2O-reducing bacterium Bradyrhizobium ottawaense SG09 to plant roots.
Takeguchi, Y.; Shibuya, R.; Kondo, M.; Betsuyaku, E.; Itakura, M.; Minamisawa, K.; Sugawara, M.; Betsuyaku, S.
10.1101/2025.06.05.658015 — microbiology — Posted on 2025-06-06
1736 Dendritic inhibition terminates plateau potentials in CA1 pyramidal neurons
Vaasjo, L. O.; Kotermanski, S. E.; Patel, T.; Shi, H. J.; Machold, R.; Chamberland, S.
10.1101/2025.06.05.657434 — neuroscience — Posted on 2025-06-06
1738 Two time scales of adaptation in human learning rates
Simoens, J.; Braem, S.; Verbeke, P.; Chen, H.; Mattioni, S.; Chai, M.; Schuck, N. W.; Verguts, T.
10.1101/2025.06.05.658048 — neuroscience — Posted on 2025-06-06
1742 Extracellular Vesicles from Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement, and Aging-related Pathway Dysregulation
Jank, L.; Satheesh Kumar, M. K.; Ryu, T.; Thapa, R.; Gololobova, O.; Niepokny, T.; Calabresi, P. A.; Witwer, K. W.; Dutta, R.; Na, C. H.; Bhargava, P.
10.1101/2025.06.02.657509 — neuroscience — Posted on 2025-06-06
1743 Heritable Large Deletions Using Type I-E CRISPR-Cas3 in Rice
Saika, H.; Hara, N.; Yasumoto, S.; Muranaka, T.; Yoshimi, K.; Mashimo, T.; Toki, S.
10.1101/2025.06.05.658196 — plant biology — Posted on 2025-06-06
1744 aNy-way ICA and its application to estimate cortico-thalamo-cerebellar functional links in schizophrenia
Duan, K.; Silva, R. F.; Rahaman, M. A.; Fu, Z.; Liu, J.; Kochunov, P.; van Erp, T. G. M.; Shultz, S.; Calhoun, V. D.
10.1101/2025.06.02.657541 — neuroscience — Posted on 2025-06-06
1745 Regulators of Interferon-Responsive Microglia Uncovered by Genome-wide CRISPRi Screening
McQuade, A.; Castillo, V. C.; Hagan, V.; Liang, W.; Ta, T.; Mishra, R.; Teter, O.; Teyssier, N.; Leng, K.; Kampmann, M.
10.1101/2025.06.05.658176 — neuroscience — Posted on 2025-06-06
1746 Neural coding of spectrotemporal modulations in the auditory cortex supports speech and music categorization
Ginzburg, J.; Debaque, E. C.; Borderie, A.; Morillon, B.; Martineau, L.; Bonaventure, P. L.; Albouy, P.; Zatorre, R.
10.1101/2025.06.05.657930 — neuroscience — Posted on 2025-06-06
1748 Increasing Stemness Drives Prostate Cancer Progression, Plasticity, Therapy Resistance and Poor Patient Survival
Liu, X.; Cortes, E.; Ji, Y.; Zhao, K.; Ho, J.; Liu, Y. S.; Davicioni, E.; Feng, F. Y.; Alumkal, J. J.; Spratt, D. E.; Sweeney, C. J.; Yu, H.; Hu, Q.; Cheng, Z.; Zhang, D.; Chatta, G.; Nastiuk, K. L.; Goodrich, D. W.; Rycaj, K.; Jamroze, A.; Kirk, J. S.; Puzanov, I.; Liu, S.; Wang, J.; Tang, D. G.
10.1101/2025.04.27.650697 — cancer biology — Posted on 2025-06-06
1752 Spontaneous cell morphogenesis via self-propelled actin filaments
Yagami, K.; Baba, K.; Minegishi, T.; Misu, S.; Katsuno-Kambe, H.; Okano, K.; Sakumura, Y.; Hosokawa, Y.; Inagaki, N.
10.1101/2024.02.28.582450 — cell biology — Posted on 2025-06-06
1753 Towards Unified Neural Decoding with Brain Functional Network Modeling
Wu, D.; Bu, L.; Jia, Y.; Cao, L.; Li, S.; Zhou, Y.; Fan, S.; Ren, W.; Wu, D.; Wang, K.; Zhang, Y.; Ma, Y.; Yang, J.; Sawan, M.
10.1101/2025.06.02.657011 — neuroscience — Posted on 2025-06-05
1755 Phosphoproteome modifications and cortical circuit dysfunction are linked to the early-stage progression of alpha-synuclein aggregation.
Dutta, S.; Hensel, J.; Scott, A.; Mohallem, R.; Rossitto, L.-A. M.; Khan, H. F.; Johnson, T.; Ferreira, C. R.; Diehl, L. A.; Marmolejo, J. F.; Chen, X.; Jayant, K.; Aryal, U. K.; Volpicelli-Daley, L.; Rochet, C.
10.1101/2025.01.24.634820 — neuroscience — Posted on 2025-06-06
1756 A continuous landscape of signaling encodes a corresponding landscape of CAR T cell phenotype
Cho, W.; Liu, J. Y.; Beckett, A. N.; Lunger, J. C.; Xu, P.; Ho, K.; Chen, E. E.; Salcido-Alcantar, A.; Sant'Anna, L. E.; Obbad, K.; Po, N.; Sotillo, E.; Mackall, C. L.; Daniels, K. G.
10.1101/2025.06.05.658149 — synthetic biology — Posted on 2025-06-05
1757 Non-Invasive Mechanical-Functional Analysis of Individual Liver Mitochondria by Atomic Force Microscopy
Zorikova, E. O.; Chourasia, S.; Rosenhek-Goldian, I.; Cohen, S. R.; Nesterov, S. V.; Gross, A.
10.1101/2025.06.01.657242 — biophysics — Posted on 2025-06-05
1759 De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors
Muratspahic, E.; Feldman, D.; Kim, D. E.; Qu, X.; Bratovianu, A.-M.; Rivera-Sanchez, P.; Dimitri, F.; Cao, J.; Cary, B. P.; Belousoff, M. J.; Keov, P.; Chen, Q.; Ren, Y.; Fine, J.; Sappington, I.; Schlichthaerle, T.; Zhang, J. Z.; Pillai, A.; Mihaljevic, L.; Bauer, M.; Torres, S. V.; Motmaen, A.; Lee, G. R.; Tran, L.; Wang, X.; Goreshnik, I.; Vafeados, D. K.; Svendsen, J. E.; Hosseinzadeh, P.; Lindegaard, N.; Brandt, M.; Waltenspühl, Y.; Deibler, K.; Oostdyk, L.; Cao, W.; Anantharaman, L.; Stewart, L.; Halloran, L.; Spangler, J. B.; Sexton, P. M.; Roth, B. L.; Krumm, B. E.; Wootten, D.; Tate,
10.1101/2025.03.23.644666 — bioengineering — Posted on 2025-06-05
1760 Deciphering the thiolactonization mechanism in thiolactomycin biosynthesis
Guo, J.; Zhang, Q.; Shen, Y.; Cheng, F.; Sang, M.; Wang, X.; Pan, Y.; Liu, M.; Yu, H.-B.; Hu, B.; Wang, S.; Zheng, L.; Geng, C.; Yang, C.; Luo, L.; Zhang, G.; Du, L.; Li, Y.; Zhang, W.; Zhang, Y.; Wang, B.; Li, S.; Zhang, X.
10.1101/2024.12.18.629141 — biochemistry — Posted on 2025-06-05
1762 Inhalable Perfluorocarbon Nanocapsules for RNA-based Immunotherapeutic Treatment of Lung Metastases
Siddhanta, K.; Monirvaghef, A.; Sundar, A.; Pinkerton, B. R.; Kumari, N.; Ding, L.; Woslager, C. J.; Kalpana, M. A.; Jogdeo, C. M.; Ravnholdt, A. R.; Poole, J. A.; Santarpia, J.; Talmadge, J. E.; Oupicky, D.
10.1101/2025.06.05.658088 — bioengineering — Posted on 2025-06-05
1763 Aromatic Patch in WhiB-Like Transcription Factors Facilitates Primary Sigma Factor Interaction in Mycobacterium tuberculosis
Beltran, D. G.; Wan, T.; Seravalli, J.; Horova, M.; Jones, C.; Li, S.; Ma, P.; Becker, D.; Mower, J. P.; Yao, Q.; Pan, Y.; Yu, H.; Steyn, A. J.; Zhang, L.
10.1101/2025.06.05.653497 — biochemistry — Posted on 2025-06-05
1764 Changes in biophysical characteristics of YghA from E. coli due to variation in pH
Hasan, N.; Jilani, S. B.; Saeed, S.; Stoner, M. R.; Yazdani, S. S.; Choi, Y.; Khan, R. H.
10.1101/2025.06.05.657471 — biochemistry — Posted on 2025-06-05
1769 RNA structure directs RNA partitioning and is actively disrupted inside stress granules to enable cellular recovery
Zhu, B.; Lim, J. J. A.; Zhang, Y.; Tan, W. T.; Zhang, J.; Xiang, J. S. N.; Huber, R.; Khong, A.; Wan, Y.
10.1101/2025.06.05.658090 — molecular biology — Posted on 2025-06-05
1775 A continuous landscape of signaling encodes a corresponding landscape of CAR T cell phenotype
Cho, W.; Liu, J. Y.; Beckett, A. N.; Lunger, J. C.; Xu, P.; Ho, K.; Chen, E. E.; Salcido-Alcantar, A.; Sant'Anna, L. E.; Obbad, K.; Po, N.; Sotillo, E.; Mackall, C. L.; Daniels, K. G.
10.1101/2025.06.05.658149 — synthetic biology — Posted on 2025-06-05
1779 The Immunophenotype and Proviral Landscape of HIV-infected CD4 T Cells During Antiretroviral Therapy
Delley, C. L.; Shah, S.; Joslin, K. M.; Park, Y. P.; Busch, M. P.; Stone, M.; Demaree, B.; Deeks, S. G.; Boritz, E. A.; Abate, A. R.; Clark, I. C.
10.1101/2025.06.05.657210 — genomics — Posted on 2025-06-05
1782 Evaluation of Enterobacterales carrying Acinetobacter-associated blaOXA genes--United States, 2017-2022
Orazi, G.; Kent, A. G.; Wilmott, N.; Berhe, D.; Longo, C.; Bumpus-White, P.; Rutledge, D.; Hovan, G.; Villegas Correa, I. M.; Otero Pagan, I.; Coe, P.; Therrien, M.; Bhatnagar, A.; McKay, S. L.; Brown, A. C.; Laufer Halpin, A.; Sabour, S.
10.1101/2025.06.05.655513 — microbiology — Posted on 2025-06-05
1784 Training-induced alterations in the modulation of human motoneuron discharge patterns with contraction force
Skarabot, J.; Thomason, H.; Nazaroff, B. M.; Connelly, C. D.; Valencic, T.; Ho, M. L.; Tyagi, K.; Beauchamp, J. A.; Pearcey, G. E.
10.1101/2025.06.02.657380 — neuroscience — Posted on 2025-06-05
1785 Cell-surface proteomic profiling identifies CD72 as a regulator of microglial tiling
Chan, T. C.; Rastogi, M.; Williams, M. X.; Zhang, S.; Shi, S. M.; Shuken, S. R.; Bartling, T.; Wild, K.; Atkins, M.; Hahn, O.; Paulo, J. A.; Jereb, S.; Shuster, S. A.; Yoo, Y.; Napole, A.; Hernandez, V. G.; Luo, L.; Buckwalter, M. S.; Stevens, B.; Deverman, B. E.; Kronenberg-Versteeg, D.; Gygi, S. P.; Wyss-Coray, T.; Wernig, M.
10.1101/2025.06.02.657480 — neuroscience — Posted on 2025-06-05
1787 A resource and computational approach for quantifying gene editing allelism at single-cell resolution
Ung, M. H.; Angelini, G.; Wang, R.; Pyclik, A.; Lydeard, J. R.; Ferrucio, J. X.; Lin, M. I.; Chakraborty, T.; Ge, H. G.
10.1101/2025.05.22.653824 — bioinformatics — Posted on 2025-06-05
1790 Plasma insulin-like growth-factor 1 (IGF-1) concentrations predict early life-history traits in a wild mammal
Ravindran, S.; Corripio-Miyar, Y.; Pick, J. L.; Bal, X.; Pilkington, J. G.; Pemberton, J. M.; Nussey, D. H.; Froy, H.
10.1101/2025.06.02.656453 — ecology — Posted on 2025-06-05
1791 Mid-infrared chemical imaging of living cells enabled by plasmonic metasurfaces
Huang, S. H.; Shen, P.-T.; Mahalanabish, A.; Sartorello, G.; Li, J.; Liu, X.; Shvets, G.
10.1101/2024.09.17.613596 — cell biology — Posted on 2025-06-05
1792 Immunofocusing on the conserved fusion peptide of HIV envelope glycoprotein in rhesus macaques
Pratap, P. P.; Cottrell, C. A.; Quinn, J.; Carnathan, D. G.; Bader, D. L. V.; Tran, A. S.; Enemuo, C. A.; Ngo, J. T.; Richey, S. T.; Gao, H.; Shen, X.; Greene, K. M.; Hurtado, J.; Michaels, K. K.; Ben-Akiva, E.; Lemnios, A.; Melo, M. B.; Allen, J. D.; Ozorowski, G.; Crispin, M.; Briney, B.; Montefiori, D.; Silvestri, G.; Irvine, D. J.; Crotty, S.; Ward, A. B.
10.1101/2024.11.27.625755 — immunology — Posted on 2025-06-05
1793 PointTree: Automatic and accurate reconstruction of long-range axonal projections of single-neuron
Cai, L.; Fan, T.; Qu, X.; Zhang, Y.; Gou, X.; Ding, Q.; Feng, W.; Cao, T.; Lv, X.; Liu, X.; Huang, Q.; Quan, T.; Zeng, S.
10.1101/2024.09.23.614432 — neuroscience — Posted on 2025-06-05
1796 Redistribution of fragmented mitochondria ensure symmetric organelle partitioning and faithful chromosome segregation in mitotic mouse zygotes
Gekko, H.; Nomura, R.; Kuzuhara, D.; Kaneyasu, M.; Koseki, G.; Adhikari, D.; Mio, Y.; Carroll, J.; Kono, T.; Funahashi, H.; Wakai, T.
10.1101/2024.06.13.598818 — developmental biology — Posted on 2025-06-05
1797 Novel Adomaviruses Associated with Blotchy Bass Syndrome in Black Basses (Micropterus spp.)
Iwanowicz, L. R.; Raines, C. D.; Young, K. T.; Blazer, V. S.; Walsh, H. L.; Smith, G.; Holt, C.; Odenkirk, J.; Jones, T.; Hessenauer, J.-M.; Biggs, M.; Buck, C. B.; Greer, J.; Cornman, R. S.
10.1101/2025.06.01.657292 — microbiology — Posted on 2025-06-05
1798 Characterization of Sex-Based Differences in Integrin-Mediated Endothelial Cell Adhesion to Bioactive Hydrogels
Nkansah, A.; Budhwani, A.; Grammer, N.; Ang, N.; Fairley, A.; Salazar, S. P.; Anand, A.; Yedalla, A. C.; Seidlits, S.; Allen, J.; Cosgriff-Hernandez, E.
10.1101/2025.06.02.656802 — bioengineering — Posted on 2025-06-05
1799 The impact of RNA chemical probing reagents on RNA binding proteins
Klingler, D.; Fallon, L.; Cohn, D.; Crawford, A.; Marcus, L.; Jones, A. N.
10.1101/2024.03.21.586119 — biochemistry — Posted on 2025-06-05
1801 CBP-IDRs regulate acetylation and gene expression.
Gelder, K. L.; Carruthers, N. A.; Gilbert, G.; Harrison, L. J.; Evans, T.; Ball, S. S.; Dunning, M.; Craggs, T. D.; Twelvetrees, A. E.; Bose, D. A.
10.1101/2024.06.04.597392 — molecular biology — Posted on 2025-06-05
1802 Mutant Huntingtin exon1 protein detected in mouse brain with neoepitope antibody: effects of CAG repeat expansion, MSH3 silencing, and aggregation
Sapp, E.; Boudi, A.; Iwanowicz, A.; Belgrad, J.; Miller, R.; Robertson, R.; O'Reilly, D.; Yamada, K.; Deng, Y.; Joni, M.; Li, X.; Kegel-Gleason, K.; Khvorova, A.; Reiner, A.; Aronin, N.; DiFiglia, M.
10.1101/2024.12.31.630891 — neuroscience — Posted on 2025-06-05
1803 Endothelin B receptor inhibition rescues aging-dependent neuronal regenerative decline
Feng, R.; Rosen, S. F.; Ansari, I.; John, S.; Thomsen, M. B.; Avraham, O.; Geoffroy, C. G.; Cavalli, V.
10.1101/2024.06.08.597928 — neuroscience — Posted on 2025-06-05
1804 Inferring cell dynamics in stress-induced neuroblastoma cell cultures
Hafiichuk, K.; Hamis, S.; Karlsson, J.; Gisselsson, D.; Chattopadhyay, S.
10.1101/2025.03.17.643601 — cancer biology — Posted on 2025-06-05
1805 Making AI accessible for forensic DNA profile analysis
de Wit, A. K. J. G.; Wagenaar, C. D.; Janssen, N. A.; Hoegen, B.; van de Wetering, J.; Hoofs, H.; Ariëns, S.; Benschop, C. C.; Ypma, R. J.
10.1101/2025.06.02.656996 — bioinformatics — Posted on 2025-06-05
1808 Deep learning from videography as a tool for measuring E. coli infection in poultry
Scheidwasser, N.; Poulsen, L. L.; Leow, P. R.; Khurana, M. P.; Iglesias-Carrasco, M.; Laydon, D. J.; Donnelly, C. A.; Bojesen, A. M.; Bhatt, S.; Duchene, D. A.
10.1101/2024.11.20.624075 — animal behavior and cognition — Posted on 2025-06-05
1810 Shola Sky Islands Survey 2025
P, S. M.; L, R. R.; K, S. E.; K, V. C.
10.1101/2025.05.29.656751 — ecology — Posted on 2025-06-05
1811 Cell fate specification during respiratory development requires ARID1A-containing canonical BAF complex activity
Lee, H.; Jaquish, A.; Fernandes, S.; Zhao, B.; Elitz, A.; Cook, K.; Trovillion, S.; Arias, N. M. B.; Han, S.; Goodwin, S.; Russell, N.; Zacharias, A. L.; Brugmann, S. A.; Whitsett, J. A.; Sinner, D. I.; Sun, X. I.; Swarr, D. T.; Zacharias, W. J.
10.1101/2025.06.02.657302 — developmental biology — Posted on 2025-06-05
1816 Perimenopause promotes neuroinflammation in select hippocampal regions in a mouse model of Alzheimers disease
Marongiu, R.; Platholi, J.; Park, L.; Yu, F.; Sommer, G.; Woods, C.; Milner, T. A.; Glass, M. J.
10.1101/2025.03.14.643317 — neuroscience — Posted on 2025-06-05
1817 Leveraging autophagy and pyrimidine metabolism to target pancreatic cancer
Dufresne, S.; Kuna, R. S.; Wong, K.; Komarla, A.; Rock, A.; Rosada-Encarnacion, J.; Shen, C.; Mondal, P.; Parham, L. R.; Layng, F. I.; Peck, K. L.; Fowler, A.; Lowy, A. M.; Engle, D.; Tiriac, H.; Shaw, R.; Cosford, N.; Metallo, C.; Towers, C. G.
10.1101/2025.05.29.656904 — cancer biology — Posted on 2025-06-05
1822 An Evaluation of the Tumor Microenvironment through CALR,IL1R1,IFNB1,and IFNG to Assess Prognosis and Immunotherapy Response in Bladder Cancer Patients
Lilong, L.; Zhenghao, L.; Lei, F.; Zhipeng, Y.; Junyi, H.; Yaxin, H.; Yang, L.; Yuhong, D.; Yingchun, K.; Ke, C.; Yi, H.; Zheng, L.
10.1101/2024.01.24.577030 — immunology — Posted on 2025-06-05
1824 A spatial transcriptomic atlas of acute neonatal lung injury across development and disease severity
Mallapragada, S.; Lyu, R.; Williams-Katek, A. L.; Fischer, B. K.; Vannan, A.; Hadad, N.; Mee, E. D.; Shirazi, S. P.; Jetter, C. S.; Negretti, N. M.; Hilgendorff, A.; Eldredge, L. C.; Deutsch, G. H.; McCarthy, D. J.; Kropski, J. A.; Sucre, J. M. S.; Banovich, N. E.
10.1101/2025.06.02.656433 — genomics — Posted on 2025-06-05
1826 Chronic benzodiazepine treatment triggers gephyrin scaffold destabilization and GABAAR subsynaptic reorganization
Chapman, C. A.; Povysheva, N.; Tarr, T. B.; Nuwer, J. L.; Meriney, S. D.; Johnson, J. W.; Jacob, T. C.
10.1101/2025.06.02.653073 — neuroscience — Posted on 2025-06-05
1830 Oxytocin release modulates acute neuroinflammation and improves brain development after pediatric traumatic brain injury
Knoop, M.; Trak, E.; Possovre, M.-L.; Van de Looij, Y.; Schirmbeck, G.; Ceyzeriat, K.; Pitetti, J.-L.; Farias Sanches, E.; Musardo, S.; Millet, P.; Tsartsalis, S.; Tournier, B. B.; Bellone, C.; Sizonenko, S. V.; Jacquens, A.; Baud, O.
10.1101/2025.06.02.652172 — neuroscience — Posted on 2025-06-05
1833 LOSS OF ARGINASE 2 DISRUPTS STRIATUM-SPECIFIC POLYAMINE HOMEOSTASIS
Nalepa, M.; Basheer, O.; Radkiewicz, M.; Skowronska, K.; Skweres, A.; Owczarek, A.; Dalka, A.; Hilgier, W.; Zielinska, M.; Samborowska, E.; Wegrzynowicz, M.
10.1101/2025.06.02.657391 — neuroscience — Posted on 2025-06-05
1835 iPSC-derived skeletal muscle spheroids for Duchenne Muscular Dystrophy modeling
Esposito, J.; Leite, F. d. S.; Barbosa, I. N.; Martins, T. M. d. M.; Olberg, G. G. d. O.; Tanoury, Z. A.; Telles-Silva, K. A.; Pardo, M. C. d. S.; Jazedje, T.; Bortolin, R. H.; Hirata, M. H.; Pourquie, O.; Zatz, M.
10.1101/2025.06.05.657880 — cell biology — Posted on 2025-06-05
1843 Prediction, Syntax and Semantic Grounding in the Brain and Large Language Models
Koelbl, N.; Rampp, S.; Kaltenhaeuser, M.; Tziridis, K.; Maier, A.; Kinfe, T.; Chavarriaga, R.; Krauss, P.; Schilling, A.
10.1101/2025.06.05.658007 — neuroscience — Posted on 2025-06-05
1849 An ultrasensitive spatial tissue proteomics workflow exceeding 100 proteomes per day
Klingeberg, M.; Krisp, C.; Fritzsche, S.; Schallenberg, S.; Hornburg, D.; Coscia, F.
10.1101/2025.06.02.657389 — systems biology — Posted on 2025-06-05
1850 Contrastive Learning-Enhanced Drug Metabolite Prediction Drives the Discovery of an Orally Bioavailable RSK4 Inhibitor for Esophageal Cancer
He, H.; Zhang, M.; Yang, X.; He, S.; Shi, X.; Hu, F.; Liu, C.; Zhang, X.; Chen, N.; Zhu, X.; Zhang, L.; Ye, T.; Zhang, R.; Yang, Y.; Wang, R.; Zhao, Z.; Chen, Z.; Qian, X.; Li, H.; Wang, Z.; Zhang, K.; Liu, K.; Li, S.
10.1101/2025.06.02.657523 — cancer biology — Posted on 2025-06-05
1851 Hepatocyte expression of fetal insulin receptor isoform contributes to the promotion of liver cancer through non-cell autonomous mechanisms
Leandre, F.; Iddir, A.; Godart, C.; Lagoutte, I.; Caldiero, A.; Souid, S.; Pinto, S.; Augustin, J.; Bou Malham, V.; Alves, A.; Aubry, R.; Imbeaud, S.; Zucman-Rossi, J.; Colnot, S.; Gougelet, A.; Desbois-Mouthon, C.
10.1101/2025.06.02.655477 — cancer biology — Posted on 2025-06-05
1853 Supervised Deep Learning for Efficient Cryo-EM Image Alignment in Drug Discovery with cryoPARES
Sanchez-Garcia, R.; Berndt, A.; Apelbaum, A.; Reeks, J.; Williams, P. A.; Poelking, C.; Deane, C.; Saur, M.
10.1101/2025.03.04.641536 — bioinformatics — Posted on 2025-06-05
1854 Characterization of Sex-Based Differences in Integrin-Mediated Endothelial Cel Adhesion to Bioactive Hydrogels
Nkansah, A.; Budhwani, A.; Grammer, N.; Ang, N.; Fairley, A.; Salazar, S. P.; Anand, A.; Yedalla, A. C.; Seidlits, S.; Allen, J.; Cosgriff-Hernandez, E.
10.1101/2025.06.02.656802 — bioengineering — Posted on 2025-06-05
1855 Precise MRI-Histology Coregistration of Paraffin-Embedded Tissue with Blockface Imaging
Wang, Y.; Ho, W.; Huszar, I. N.; DiGiacomo, P.; Taghavi, H. M.; Tao, L.; Choi, M.; Nguyen, N.; Leventis, S.; Camarillo, D. B.; Schlomer, P.; Axer, M.; Shao, W.; Rusu, M.; Cobos, I.; Nirschl, J.; Georgiadis, M.; Zeineh, M.
10.1101/2025.06.02.657335 — bioengineering — Posted on 2025-06-05
1856 Leech Speciation and Detection of Hirudin Gene among the Leech Population in Asejire Oyo State, Nigeria
Olajide, T. H.; Ajileye, A. O.; Bamikole, O. J.; Olufeagba, M.-d. B.; Adedeji, B. A.; Ademola, S. A.; Amodu, O. k.
10.1101/2025.06.02.657427 — genetics — Posted on 2025-06-05
1859 The Sphingosine-1-phosphate pathway is differentially activated in human gestational tissues.
Mbadhi, M. N.; Fujiwara, H.; Gill, R.; Mitchum, K. T.; Lin, C.; Raghuraman, N.; Frolova, A. I.
10.1101/2025.06.02.657487 — developmental biology — Posted on 2025-06-05
1860 PRPF8-associated retinitis pigmentosa variant induces human neural retina-autonomous photoreceptor defects
Zimmann, F.; Banik, P.; Kubovciak, J.; Thakur, P. K.; Capek, M.; Kolar, M.; Hruba, E.; Dobrovolny, R.; Cvackova, Z.; Barta, T.; Stanek, D.
10.1101/2025.06.04.657822 — cell biology — Posted on 2025-06-05
1864 A dendritic cell population responsible for transglutaminase 2-mediated gluten antigen presentation in celiac disease
Yang, F.-C.; Besser, H. A.; Chun, H. R.; Albertelli, M. A.; Fernandez-Becker, N. Q.; Jabri, B.; Khosla, C.
10.1101/2025.06.02.657527 — immunology — Posted on 2025-06-05
1865 CD14 plays a critical role in pain and inflammation across multiple models of post-traumatic osteoarthritis
Burt, K. G.; South, S. M.; Adamczyk, N. S.; Nguyen, V.; Ishihara, S.; Zhou, C.; Sharp, K. L.; Kim, S. Y.; Rapp, A. E.; Hu, B.; Murphy, L. A.; Hung, L.-Y.; Herbert, D.; Baker, J.; Mauck, R. L.; Griffin, T. M.; Malfait, A.-M.; Miller, R. E.; Scanzello, C. R.
10.1101/2025.06.02.657478 — immunology — Posted on 2025-06-05
1866 Replaying germinal center evolution on a quantified affinity landscape
DeWitt, W. S. S.; Vora, A. A.; Araki, T.; Galloway, J. G.; Alkutkar, T.; Bortolatto, J.; Castro, T. B.; Dumm, W.; Jennings-Schaffer, C.; Jia, T.; Mesin, L.; Ozorowski, G.; Pae, J.; Ralph, D. K.; Bloom, J. D.; Nourmohammad, A.; Song, Y. S.; Ward, A.; Starr, T. N.; Matsen, F. A.; Victora, G. D.
10.1101/2025.06.02.656870 — immunology — Posted on 2025-06-05
1867 A High-Resolution Atlas of the Brain Predicts Lineage and Birth Order Underly Neuronal Identity.
Allen, A. M.; Neville, M. C.; Nojima, T.; Alejevski, F.; Agarwal, D.; Sims, D.; Goodwin, S. F.
10.1101/2025.06.04.657818 — neuroscience — Posted on 2025-06-05
1869 Primary tumor microbiomes predict distant metastasis of colorectal cancer
Parajuli, B.; Midya, V.; Kiddle, R.; De Jager, N.; Eggers, S.; Spakowicz, D.; Hoyd, R.; Salhia, B.; Chan, C. H.; Churchman, M.; Rounbehler, R. J.; Yao, S.; Rutkowski, M. R.; Tarhini, A. A.; Mudaranthakam, D. P.; Masood, A.; Bocklage, T. J.; Lentz, R. W.; Hatoum, H.; Ilozumba, M. N.; Hardikar, S.; Ulrich, C. M.; Round, J. L.; Riedlinger, G.; Shriver, C. D.; Bosch, D. E.
10.1101/2025.06.02.654060 — cancer biology — Posted on 2025-06-05
1870 Biologically-informed machine learning identifies a new clinically-actionable bladder cancer subgroup characterised by NRF2 overactivity
Ungureanu, V. V.; Gawne, R. T.; Baker, S. C.; Eriksson, P.; Halliday, D. M.; Smith, S. L.; Southgate, J.; Mason, A. S.
10.1101/2025.06.03.657659 — cancer biology — Posted on 2025-06-05
1871 Association of GADD45A and favorable outcome in hormone positive breast cancer
Lin, C.-Y.; Liu, C.-Y.; Chao, T.-C.; Huang, C.-C.; Tsai, Y.-F.; Tseng, L.-M.; Lai, J.-I.
10.1101/2025.06.02.657315 — cancer biology — Posted on 2025-06-05
1873 Macrophage-derived reactive oxygen species promote Salmonella aggresome formation contributing to bacterial antibiotic persistence
Chen, X.; Fang, K.; Li, B.; Li, Y.; Ke, Y.; Ke, W.; Tian, T.; Zhao, Y.; Wang, L.; Geng, J.; Leake, M. C.; Bai, F. C.
10.1101/2025.06.03.657582 — biophysics — Posted on 2025-06-05
1877 TCRanalyzer: A user-friendly tool for comprehensive analysis of T-cell diversity, dynamics and potential antigen targets
Seifert, N.; Reinke, S.; Kurz, N. S.; Demmer, J. A.; Kornrumpf, K.; Beissbarth, T.; Klapper, W.; Altenbuchinger, M.
10.1101/2025.05.09.652820 — bioinformatics — Posted on 2025-06-05
1880 Mechanical force-mediated cellular crosstalk maintains the integrity of the lung gas exchange niche
Shen, C.; Morley, M. P.; Zhao, G.; Jones, D. L.; Schaefer, S. E.; Planer, J. D.; Chembazhi, U. V.; Kim, M.; Ying, Y.; Zhou, S.; Li, S.; Hallquist, H.; Lange, A.; Basil, M. C.; Morrisey, E. E.
10.1101/2025.06.04.657878 — cell biology — Posted on 2025-06-05
1881 Caveolin-1 dependent regulation of cell-matrix interphase in 3D collagen gels.
Mazumdar, D.; Kataria, S.; Panda, G. P.; Kulkarni, A.; Patil, S. P. V.; Dash, M.; Balasubramanian, N.
10.1101/2025.06.04.657900 — cell biology — Posted on 2025-06-05
1883 TGF-β serves as a critical signaling determinant of liver progenitor cell fate and function
Tong, C.; Lin, T.; Wang, H.; La Torre, C. D.; Liu, H.; Shao, C.; Hammad, S.; Liebe, R.; Ebert, M. P.; Ding, H.; Dooley, S.; Weng, H.-L.
10.1101/2025.06.04.657336 — cell biology — Posted on 2025-06-05
1884 Senescent mast cells contribute to the progression of benign prostatic hyperplasia via SCF/c-KIT mediated endothelial-mesenchymal transition
Jing, Y.; Li, L.; Guo, W.; Cao, T.; Tang, J.; Zhou, D.; Yao, C.; Xu, J.; Liu, Y.; Feng, C.; Shi, Y.; Wang, M.; Chao, W.; Liao, H.; He, J.; Qin, L.; Luan, J.; Wang, X.; Cui, D.; Zhu, Y.; Ruan, Y.; Xia, S.; Han, B.
10.1101/2025.06.02.657200 — cell biology — Posted on 2025-06-05
1887 Forward genetics in C. elegans reveals genetic adaptations to polyunsaturated fatty acid deficiency
Kaper, D.; Radovic, U.; Bergh, P.-O.; Qvist, A.; Henricsson, M.; Boren, J.; Pilon, M.
10.1101/2024.11.08.622646 — cell biology — Posted on 2025-06-05
1889 Receptor-enriched analysis of functional connectivity (REACT) for understanding cannabinoid neuropsychopharmacology
Shatalina, E.; Ertl, N.; Petrilli, K.; Ofori, S.; Borisova, A.; Mokrysz, C.; Curran, V.; Lawn, W.; Freeman, T. P.; Howes, O.; Wall, M. B.
10.1101/2025.06.02.657387 — neuroscience — Posted on 2025-06-05
1890 Linking offline learning mechanisms to anxiety traits
Yu, Q.; Luo, Y.; Dolan, R. J.; Ou, J.; Huang, C.; Wang, H.; Xiao, Z.; Nour, M.; Liu, Y.
10.1101/2023.06.21.546031 — neuroscience — Posted on 2025-06-05
1891 Network-based Near-Scalp Personalized Brain Stimulation Targets
Kong, R.; Xue, A.; Ooi, L. Q. R.; Asplund, C.; Tan, X. W.; Goh, S. E.; Lee, J. J.; Koh, J. Z. J.; Tan, R. S. Y.; Singh, H. K. G.; Tan, T. W. K.; Webler, R. D.; Fox, M. D.; Siddiqi, S. H.; Tor, P.-C.; Yeo, B. T. T.
10.1101/2025.05.15.654391 — neuroscience — Posted on 2025-06-05
1892 Remodeling of purinergic signaling in the paraventricular hypothalamus promotes hyperphagic obesity and insulin resistance
Liu, Y.; Bondarenko, A.; Zhang, H.; Luan, P.; Zhang, Q.; Wang, B.; Najam, S. S.; Liang, X.; Syed, A. A. S.; Lin, D.; Huang, S.; Konovalov, R.; Konopka, W.; Zhang, Z.; Zhang, Y.; Wu, S.; Jing, M.; Vinnikov, I. A.
10.1101/2024.07.02.601503 — neuroscience — Posted on 2025-06-05
1893 OPM quantum sensors enhance non-invasive neuroimaging performance
Brickwedde, M.; Anders, P.; Krueger, P.; Sander, T.; Uhlhaas, P.
10.1101/2025.05.30.657044 — neuroscience — Posted on 2025-06-05
1894 Prognostic significance of Ki-67, BAX, Caspase-3, and VEGF expression in feline intestinal lymphoma
Faraldo, N. C.; Rosenfeld, A. d. F. S.; Brombatti, K. G.; Amorim, R. L.; Battaglia, S. T. H.; Sobral, R. A.; Fonseca Alves, C. E.
10.1101/2025.06.01.657294 — pathology — Posted on 2025-06-05
1897 Depth-resolved fiber photometry of amyloid plaque signals in freely behaving Alzheimer's disease mice
Byron, N.; McAlinden, N.; Pisano, F.; Pisanello, M.; Ferreira, J.; Montinaro, C.; Mathieson, K.; De Vittorio, M.; Pisanello, F.; Sakata, S.
10.1101/2025.04.08.647900 — neuroscience — Posted on 2025-06-05
1898 Col6 deficiency in a zebrafish model of Bethlem myopathy leads to dysfunction of the muscle dihydropyridine receptor
Idoux, R.; Exbrayat-Heritier, C.; Shivaraman, S.; Jaque-Fernandez, F.; Ducret, A.; Berthier, C.; Jacquemond, V.; Sohm, F.; bretaud, s.; Ruggiero, F.; ALLARD, B.
10.1101/2025.06.02.657388 — pathology — Posted on 2025-06-04
1900 The mutational dynamics of the Arabidopsis centromeres
Dong, X.; Jiao, W.-B.; Campoy, J. A.; Rabanal, F. A.; Ton, J.; Smith, L. M.; Weigel, D.; Schneeberger, K.
10.1101/2025.06.02.657473 — genomics — Posted on 2025-06-04
1903 Persistent cortical excitatory neuron dysregulation in adult Chd8 haploinsufficient mice.
Canales, C. P.; Lozano, S.; Frost, N. A.; Cichewicz, K.; Amaral, W.; Seban, N.; Fenton, E.; Wade, A.; Chu, N.; Smith, E.; Ardekani, C.; Frank, S.; Bennett, J.; Lavenex, P.; Kopley-Smith, A.; Rahbarian, D.; Corea, M.; Perla, D.; Davis, L.; Zhu, J.; Ortiz, R.; Beauregard, P.; Moyer, C.; Baker, J.; Sun, J.; Ma, B.; Lu, J.; Sohal, V. S.; Amaral, D. G.; Zuo, Y.; Nord, A. S.
10.1101/2025.06.04.657776 — genomics — Posted on 2025-06-04
1904 Single-nucleus epigenomic dysregulation unmasks genetic risk-associated neurodegenerative glia states
Han, X.; Zhang, T.; Lee, C.-Y.; Ravi, A.; Spina, S.; Li, A. N.; Grinberg, L. T.; Seeley, W. W.; Huckins, L. M.; Raj, T.; Brennand, K. J.; Rexach, J. E.
10.1101/2025.06.02.657512 — genomics — Posted on 2025-06-04
1905 The Insertion of an ATTTC Repeat in an Alu Element Hyperactivates a Primate-Specific Neurodevelopmental Enhancer in Spinocerebellar Ataxia Type 37
Loureiro, J. R.; Castro, A. F.; Figueiredo, A. S.; Eufrasio, A.; Dhingra, A.; Galhardo, M.; Marcelino, H.; Rodrigues, C.; Sampaio, P.; Azevedo, M. M.; Sousa, M.; Doria, S.; Rizzu, P.; Heutink, P.; Bessa, J.; Silveira, I.
10.1101/2025.06.03.657633 — genetics — Posted on 2025-06-04
1907 Malaria shaped human spatial organisation for the last 74 thousand years
Colucci, M.; Leonardi, M.; Blinkhorn, J.; Irish, S. R.; Padilla-Iglesias, C.; Kaboth-Bar, S.; Gosling, W. D.; Snow, R. W.; Manica, A.; Scerri, E. M. L.
10.1101/2025.06.04.657870 — evolutionary biology — Posted on 2025-06-04
1908 Sp Transcription Factors Establish the Signaling Environment in the Neuromesodermal Progenitor Niche During Axial Elongation
Chalamalasetty, R. B.; Tran, H.; Kelly, R.; Kuo, S.; Kennedy, M. W.; Lee, M.; Thomas, S.; Mandalos, N.; Koparde, V.; Pereira Lobo, F.; Yamaguchi, T. P.
10.1101/2025.06.03.657492 — developmental biology — Posted on 2025-06-04
1909 Cell fate specification during respiratory development requires ARID1A-containing canonical BAF complex activity
Lee, H.; Jaquish, A.; Fernandes, S.; Zhao, B.; Elitz, A.; Cook, K.; Trovillion, S.; Arias, N. M. B.; Han, S.; Goodwin, S.; Russell, N.; Zacharias, A. L.; Brugmann, S. A.; Whitsett, J. A.; Sinner, D. I.; Sun, X. I.; Swarr, D. T.; Zacharias, W. J.
10.1101/2025.06.02.657302 — developmental biology — Posted on 2025-06-04
1910 Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying SCN2A mutation
Wu, J.; Chen, X.; Zhang, J.; Wettschurack, K. W.; Robinson, M. J.; Li, W.; Zhao, Y.; Yoo, Y.-E.; Deming, B. A.; Abeyaratna, A. D.; Que, Z.; Du, D.; Tegtmeyer, M. T.; Yuan, C.; Skarnes, W. C.; Rochet, J.-C.; Wu, L.-J.; Yang, Y.
10.1101/2025.06.04.657874 — neuroscience — Posted on 2025-06-04
1915 Artemether and Euphorbia Factor L9 suppress kynurenine production through distinct effects on Tryptophan metabolism.
Capatina, A. L. L.; Czechowski, T.; Plunkett-Jones, C.; Tonon, T.; Kourtzelis, I.; Lichman, B. R.; Brackenbury, W. J.; Graham, I. A.; Lagos, D.
10.1101/2025.06.02.657401 — cancer biology — Posted on 2025-06-04
1920 Functional insights into the photoactive yellow protein family from homologs, multidomain proteins and inferred pyp operons
Dohmen, R.; Hoogerwerf, G.; Dohmen, A. J.; Neal, M. L.; Bradley, C.; Huffman, C.; Teeman, S. M.; Hampton, S. F.; Powell, S.; Gunn, Z.; Hoff, W. D.
10.1101/2025.06.04.657921 — microbiology — Posted on 2025-06-04
1921 Desiccation-induced DNA damage facilitates drug resistance in Mycobacterium tuberculosis
Brown, C. D.; Lee, B. M.; Liu, H.; Wu, A.; Tellez, A. V.; Zou, H.; Singh, P.; Saito, K.; Mishra, S.; Brown, M.; Saleh, A.; Odjourian, N. M.; Cristaldo, M.; Gan, M.; Liu, Q.; Gengenbacher, M.; Darst, S. A.; Campbell, E. A.; Nathan, C. F.; Rhee, K. Y.
10.1101/2025.06.04.657859 — microbiology — Posted on 2025-06-04
1923 Cell-free genome-wide transcriptomics through machine learning optimization
Wagner, L.; HOANG, A.; RUE, O.; Delumeau, O.; Loux, V.; Faulon, J.-L.; Jules, M.; Borkowski, O.
10.1101/2025.06.04.657821 — synthetic biology — Posted on 2025-06-04
1924 Plasmodium falciparum subverts neutrophil function via host miR-451a loaded extracellular vesicles driving bacterial superinfection susceptibility
Babatunde, K. A.; Ngara, M.; Martinez Murillo, P.; Subramanian, B.; Hopke, A.; Lucchesi, S.; Novedrati, M.; Montesi, G.; Santoro, F.; Hagemann-Jensen, M.; Sandberg, R.; Filgueira, L.; Irimia, D.; Walch, M.; Mantel, P.-Y.
10.1101/2025.06.02.657463 — immunology — Posted on 2025-06-04
1925 Inter-individual variability in immune responses to AAV-mediated ocular gene delivery across species impedes reliable immunomonitoring profile
REN, D.; CHAUVEAU, G.; VENDOMELE, J.; CABON, E.; PINEIRO, A.; VIGNAL-CLERMONT, C.; SALIBA, H.; RONZITTI, G.; GALY, A.; DALKARA, D.; PULMAN, J.; AIL, D.; FISSON, S.
10.1101/2025.06.02.656863 — immunology — Posted on 2025-06-04
1927 Platelet concentrate-derived extracellular vesicles promote adult hippocampal neurogenesis
NyamErdene, A.; Thao Ngoc Le, N.; Nebie, O.; Faivre, E.; Delila, L.; Chou, M. L.; Lowe, J.; Bantubungi, K.; Buee, L.; Walker, T.; Blum, D.; Burnouf, T.
10.1101/2025.04.29.651163 — neuroscience — Posted on 2025-06-04
1929 Towards Unmanned Proteomics Data Generation: A Fully Automated Sample-to-Data System for Proteomic Experiments
Wang, D.; Chen, W.; Xie, L.; Xu, Y.; Huang, C.; Liu, Y.; Wang, X.; Huang, X.; Zhang, K.; Pan, M.; Wang, S.; Qin, B.; Yang, Y.; Yang, J.; Tang, L.; Tian, R.; He, F.
10.1101/2025.06.02.656978 — biochemistry — Posted on 2025-06-04
1932 Structural insights into context-specific inhibition of bacterial translation by macrolides
Syroegin, E. A.; Aleksandrova, E. V.; Kruglov, A. A.; Paranjpe, M. N.; Svetlov, M. S.; Polikanov, Y. S.
10.1101/2025.06.03.657637 — molecular biology — Posted on 2025-06-04
1933 Human cytomegalovirus-encoded G protein-coupled receptor (GPCR), UL78, regulates viral reactivation
Osanyinlusi, S. A.; Baruah, V.; Groves, I. J.; Kulp, K. H.; Krishna, B. A.; O'Connor, C. M.
10.1101/2025.06.04.657869 — microbiology — Posted on 2025-06-04
1935 Gut microbiota of Brazilian Melipona stingless bees: dominant members and their localization in different gut regions
Tristao Santini, A.; Cerqueira, A. E. S.; Moran, N. A.; Resende, H. C.; Santana, W. C.; de Paula, S. O.; da Silva, C. C.
10.1101/2025.06.03.657762 — microbiology — Posted on 2025-06-04
1936 Identification of a Broadly Acting Inhibitor of the Alphavirus Non-Structural Protein 2 Helicase
Sears, J. D.; Ojha, D.; Taft-Benz, S.; Sylvester, P. A.; Streblow, Z.; Gramm, A. J.; Drobish, A. M.; Ramalingam, B. M.; Hossain, M. A.; Talbot, K. M.; Sanders, W.; Chang, C.-K.; Law, I.; Martinez, S. A.; Burdick, J. E.; Wiltshire, R.; Saba, N. A.; Poplarski, J. H.; Counago, R. M.; Brown, P. J.; Anand, G. S.; Morrison, T. E.; Arnold, J. J.; Cameron, C. E.; Streblow, D. N.; Willson, T. M.; Heise, M. T.; Moorman, N. J.
10.1101/2025.06.03.657755 — microbiology — Posted on 2025-06-04
1938 Common and distinct neural correlates of social interaction perception and theory of mind
Miao, Z.; Jung, H.; Kragel, P. A.; Bo, K.; Sadil, P.; Lindquist, M. A.; Wager, T. D.
10.1101/2024.12.19.628993 — neuroscience — Posted on 2025-06-04
1940 An artificial nervous system for communication between wearable and implantable therapeutics
Ghanim, R.; Lee, Y. J.; Byun, G.; Jackson, J.; Ding, J. Z.; Feller, E.; Kim, E.; Aygun, D.; Kaushik, A.; Cig, A.; Park, J.; Healy, S.; Cunin, C. E.; Gumyusenge, A.; Yeo, W. H.; Abramson, A.
10.1101/2025.06.04.657863 — bioengineering — Posted on 2025-06-04
1941 Perilipin 4 repetitive region forms amyloid fibrils promoted by a genetic expansion found in myopathy patients
Choufani, C.; Fuggetta, N.; Sabbagh, B.; Moulin, C.; Franckhauser, C.; Lyonnais, S.; Perme, T.; Arteni, A.-A.; Pagnotta, S.; Rouquier, S.; Ruggieri, A.; Bousset, L.; Copic, A.
10.1101/2025.06.03.657256 — biochemistry — Posted on 2025-06-04
1942 Assembly and phospho-regulatory mechanisms of the budding yeast outer kinetochore KMN complex
Turner, N. N.; Zhang, Z.; Muir, K. W.; McLaughlin, S. H.; Morgan, T.; Barford, D.
10.1101/2025.06.03.657598 — biochemistry — Posted on 2025-06-04
1944 PKP2 orchestrates OXPHOS expression in cardiomyocytes via a PGC1α-dependent mechanism
Han, S. J.; den Berg, D.; de Ruiter, H.; Tsui, H.; Kyriakopoulou, E.; Koopmans, T.; Perini, I.; Monshouwer-Kloots, J.; van Kampen, S. J.; te Riele, A. S. J. M.; Kelters, I. R.; Gianoli, M.; Burgering, B. M. T.; van Rooij, E.
10.1101/2025.06.02.656790 — molecular biology — Posted on 2025-06-04
1945 Clinical Trypanosoma cruzi isolates share a common antigen repertoire that is absent from culture adapted strains
Hakim, J. M. C.; Gutierrez Guarnizo, S. A.; Duran, A.; Malaga-Machacha, E.; Duque, C.; Singer, L.; Colanzi, R.; Sherbuk, J. E.; Gilman, R.; Bern, C.; Messenger, L. A.; Mugnier, M. R.; Working Group on Chagas Disease in Bolivia and Peru,
10.1101/2025.06.04.657671 — microbiology — Posted on 2025-06-04
1948 R-Spondin Mimetic, SZN-043, Induced Proliferation and Expression of Wnt Target Genes, Two Impaired Features in Human Alcohol-Associated Liver Disease
Fisher, T.; Patel, M.; Deshmukh, S.; Shah, D.; Lu, C.; Newman, M.; Ye, J.; Fletcher, R.; Vanhove, G. F.; Tibbitts, J.; Li, Y.; Skill, N. J.; Yang, Z.; Liangpunsakul, S.; Baribault, H.
10.1101/2024.11.19.624277 — pathology — Posted on 2025-06-04
1952 The evolution of separate sexes in waterhemp is associated with surprising chromosomal diversity and complexity
Kreiner, J. M.; Montgomery, J. S.; Todesco, M.; Bercovich, N.; Gong, Y.; Elphinstone, C.; Tranel, P. J.; Rieseberg, L. H.; Wright, S. I.
10.1101/2024.09.17.613486 — evolutionary biology — Posted on 2025-06-04
1955 Efficient Generation of Expandable Dorsal Forebrain Neural Rosette Stem Cell Lines
Frazier, S. E. D.; de Lichtenberg, K. H.; Jaberi, E.; Bertelsen, C.; Jensen, S. M.; Wrona, A.; Christophersen, N. S.; Kristensen, M.; Villaescusa, J. C.
10.1101/2025.05.27.656305 — neuroscience — Posted on 2025-06-04
1956 Population structure of Phytophthora infestans collected from potatoes in Guatemala and Honduras
Izarra, M. L.; Perez, W. G.; Vasquez, E. F.; Perez, G. E.; Gamboa, S.; Andrade-Piedra, J.; Flores, B.; Montejo, L.; Sanders, A.; Kreuze, J. F.
10.1101/2025.05.28.656702 — pathology — Posted on 2025-06-04
1957 Reconciling the effects of PMS2 in different repeat expansion disease models supports a common therapeutic strategy
Jimenez, D. A.; Miller, C. J.; Walker, A.; Anupindi, K.; Hayward, B. E.; Lorenzi, H. A.; Usdin, K.; Zhao, X.
10.1101/2024.08.13.607839 — genetics — Posted on 2025-06-04
1960 3D Quantification of Viral Transduction Efficiency in Living Human Retinal Organoids
Rogler, T. S.; Salbaum, K. A.; Brinkop, A. T.; Sonntag, S. M.; James, R.; Shelton, E. R.; Thielen, A.; Rose, R.; Babutzka, S.; Klopstock, T.; Michalakis, S.; Serwane, F.
10.1101/2024.03.06.583795 — neuroscience — Posted on 2025-06-04
1962 The intratumoral microbiome is negatively associated with malignancy in dermatofibrosarcoma protuberans
Jian, X.; Liu, Z.; Zhang, J.; Li, Y.; Xie, L.; Zhao, G.; Li, B.; Li, J.; Peng, C.; Wan, M.; Chen, X.
10.1101/2025.06.02.657449 — microbiology — Posted on 2025-06-04
1963 The hemagglutinin proteins of clades 1 and 2.3.4.4b H5N1 highly pathogenic avian influenza viruses exhibit comparable attachment patterns to avian and mammalian tissues
Zhu, B.; Fung, K.; Feng, H. H.; Beatty, J. A.; Hill, F.; Tse, A. C.; Brackman, C. J.; Sit, T. H.; Poujade, A.; Gaide, N.; Ducatez, M.; Foucras, G.; Peiris, M.; Ti, S.-C.; Nicholls, J. M.; Yen, H.-L.
10.1101/2025.06.02.657404 — microbiology — Posted on 2025-06-04
1964 Evolutionary trajectories determine the feasibility of collateral sensitivity based antibiotic treatment strategies in critical bacterial pathogens
Brandis, G.; Chauhan, V.; Enkvist, L.; Chukhareva, Y.; Damell, C.; Cruz Davila, E.; Islam, T. M.; Melander, G.; Paulsson, E.; Sundell, A.; Zweifel, E.; Knöppel, A.
10.1101/2025.06.03.657621 — microbiology — Posted on 2025-06-04
1967 eIF4G2-Mediated Translation Initiation of Histone Modifiers Is Essential for Intestinal Stem Cell Maintenance and Differentiation
Kunitomi, H.; Khaine, A. M.; Jamee, R.; Arreola, V.; Lancero, M.; Raychaudhuri, A.; Perli, S. D.; Sato, Y.; Iwasaki, M.; Ruivo, P. R.; Tomoda, K.; Mito, M.; Shichino, Y.; Iwasaki, S.; Yamanaka, S.
10.1101/2025.05.19.652834 — cell biology — Posted on 2025-06-04
1968 Z-Form Stabilization By The Zα Domain Of Adar1p150 Has Subtle Effects On A-To-I Editing
Nichols, P. J.; Riemondy, K. A.; Krall, J. B.; Ramos, J.; Goering, R.; Henen, M. A.; Taliaferro, J. M.; Vogeli, B.; Vicens, Q.
10.1101/2025.06.02.657529 — cell biology — Posted on 2025-06-04
1969 Dendritic computation for rule-based flexible categorization
Zhang, Y.; Liu, Y.; Hu, Y.; Zhang, Z.; Du, J.; Cui, L.; Liu, Q.; Zhong, L.; Xin, Y.; Chai, R.; Deng, L.; Pan, J.; Schiller, J.; Xu, N.-l.
10.1101/2025.06.03.657766 — neuroscience — Posted on 2025-06-04
1971 MRAP2 modifies signaling and oligomerization state of the melanocortin-4 receptor
Sohail, I.; Laurin, S.-A.; Kleinau, G.; Chunilal, V.; Morton, A.; Brenlla-Lopez, A.; Kagiali, Z. C. U.; Tello, J. A.; Blouin, M.-J.; Beck-Sickinger, A. G.; Lohse, M. J.; Scheerer, P.; Bouvier, M.; McCormick, P.; Annibale, P.; Biebermann, H.
10.1101/2024.04.09.588099 — pharmacology and toxicology — Posted on 2025-06-04
1974 A heterogeneous pharmaco-transcriptomic landscape induced by targeting a single oncogenic kinase
Giglio, R. M.; Hou, N.; Wyatt, A.; Hong, J.; Shi, L.; Vaikunthan, M.; Fuchs, H.; Nima, J. P.; Malinowski, S. W.; Ligon, K. L.; McFaline-Figueroa, J. R.; Yosef, N.; Azizi, E.; McFaline-Figueroa, J. L.
10.1101/2024.04.08.587960 — genomics — Posted on 2025-06-04
1977 Dendritic computation for rule-based flexible categorization
Zhang, Y.; Hu, Y.; Zhang, Z.; Du, J.; Cui, L.; Liu, Q.; Zhong, L.; Xin, Y.; Chai, R.; Deng, L.; Pan, J.; Schiller, J.; Xu, N.-l.
10.1101/2025.06.03.657766 — neuroscience — Posted on 2025-06-04
1978 A model of the cerebellum generates gait adaptations in a reflex-based neuromusculoskeletal model during split-belt walking
Fleischmann, S.; Shanbhag, J.; Miehling, J.; Wartzack, S.; Ong, C.; Eskofier, B. M.; Koelewijn, A. D.
10.1101/2024.12.12.628122 — neuroscience — Posted on 2025-06-04
1982 Molecular Phenotypic Plasticity Informs Possible Adaptive Change of Triple-Negative Breast Cancer Cells In Vivo
Iftehimul, M.; Muganda, P. M.; Newman, R. H.; Rorie, C. J.; Harrison, S. H.; Hossain, M. T.; Thomas, M. D.; Graves, J. L.; Saha, D.
10.1101/2025.05.31.657204 — cancer biology — Posted on 2025-06-04
1985 Investigating the consequences of the mating system for drug resistance evolution in C. elegans
Trubenova, B.; Hellinga, J.; Krücken, J.; von Samson-Himmelstjerna, G.; Schulenburg, H.; Regoes, R. R.
10.1101/2024.11.07.620884 — evolutionary biology — Posted on 2025-06-04
1986 Long-term surveillance suggests multiple hybridization events by nuclear reassortment and accelerated intercontinental spread of wheat yellow rust
Hovmoeller, M. S.; Thach, T.; Algaba, J. R.; Hansen, J. G.; Meyer, M.; Hodson, D.; Nazari, K.; Park, R. R.; Tamm, R.; Moeller, M.; Schwessinger, B.; Rathjen, J. P.; Silva, P.; Riella, V.; Justesen, A. F.
10.1101/2025.05.22.655633 — evolutionary biology — Posted on 2025-06-04
1988 Genetic interaction library screening with a next-generation dual guide CRISPR system
Burgold, T.; Karakoc, E.; Goncalves, E.; Barrio-Hernandez, I.; Dwane, L.; Silva, R. O.; Souster, E.; Sharma, M.; Beck, A.; Koh, G.; Zalmas, L.-P.; Garnett, M.; Bassett, A. R.
10.1101/2024.03.28.587052 — molecular biology — Posted on 2025-06-04
1992 Kinetic-model-guided engineering of multiple S. cerevisiae strains improves p-coumaric acid production
Narayanan, B.; Jiang, W.; Wang, S.; Saez-Saez, J.; Weilandt, D. R.; Masid, M.; Hesselberg-Thomsen, V.; Borodina, I.; Hatzimanikatis, V.; Miskovic, L.
10.1101/2024.12.15.628543 — systems biology — Posted on 2025-06-04
1993 Defense-Suppressive Fragments of RIN4 generated by AvrRpt2 Participate in NDR1-dependent Activation of RPS2
Afzal, A. J.; Alam, M.; Huang, J.; Agha, M.; Da Cunha, L.; Iqbal Rai, M.; Tahir, J.; Jamroze, A.; Jones, J. D.; Mackey, D.
10.1101/2025.06.02.656948 — plant biology — Posted on 2025-06-04
1994 Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche
Masson, C.; Scandola, C.; Rinckel, J.-Y.; Proamer, F.; Janus-Bell, E.; Batool, F.; OSMANI, N.; GOETZ, J. G.; Mallo, L.; Brouard, N.; Leon, C.; Bornert, A.; Poincloux, R.; Destaing, O.; Mansson, A.; QIAN, H.; Lehmann, M.; Eckly, A.
10.1101/2024.09.30.615769 — physiology — Posted on 2025-06-04
1996 Microbial hydrocarbon degradation potential of the Baltic Sea ecosystem
Serrana, J. M.; Dessirier, B.; Nascimento, F. J. A.; Broman, E.; Posselt, M.
10.1101/2025.06.02.657333 — ecology — Posted on 2025-06-04
1998 ONE-STEP tagging: a versatile method for rapid site-specific integration by simultaneous reagent delivery
Migliori, V.; Bruntraeger, M.; Gyulev, I.; Lichou, F.; Burgold, T.; Gitterman, D.; Iwama, S.; Trinh, A.; Washer, S. J.; Jones, C.; Trynka, G.; Bassett, A. R.
10.1101/2024.08.29.610246 — molecular biology — Posted on 2025-06-04
1999 cGAS-STING dependent type I IFN protects against Leptospira interrogans renal colonization in mice.
Gupta, S.; Matsunaga, J.; Ratitong, B.; Ismaeel, S.; Valadares, D.; West, P.; Kerur, N.; Stehlik, C.; Dorfleutner, A.; Dagvadorj, J.; Coburn, J.; Wolf, A.; Cassel, S.; Haake, D.; Sutterwala, F. S.
10.1101/2025.06.02.657349 — immunology — Posted on 2025-06-04
2000 Memory by a thousand rules: Automated discovery of multi-type plasticity rules reveals variety and degeneracy at the heart of learning.
Confavreux, B.; Harrington, Z.; Kania, M.; Ramesh, P.; Krouglova, A. N.; Bozelos, P. A.; Macke, J. H.; Saxe, A. M.; Goncalves, P. J.; Vogels, T. P.
10.1101/2025.05.28.656584 — neuroscience — Posted on 2025-06-04
2003 Pasta, an age-shift transcriptomic clock, maps the chemical and genetic determinants of aging and rejuvenation
Salignon, J.; Tsiokou, M.; Marques, P.; Rodriguez-Diaz, E.; Ang, H.; Pietrocola, F.; Riedel, C. G.
10.1101/2025.06.04.657785 — bioinformatics — Posted on 2025-06-04
2004 REnformer, a single-cell ATAC-seq predicting model to investigate open chromatin sites
Riva, S. G.; Sanders, E.; Wilson, T.; Stranieri, N.; Gur, R.; Baxter, M.; Hughes, J. R.
10.1101/2025.06.04.657786 — bioinformatics — Posted on 2025-06-04
2007 Multiscale radiobiological assessment of laser-driven very high energy electrons versus conventional electrons
Giaccaglia, C.; Bayart, E.; Dubail, M.; Varma, C.; Heinrich, S.; Gautier, J.; Tafzi, A.; Kononenko, O.; Goddet, J.-p.; Lamarre-Jouenne, I.; Fouillade, C.; Flacco, A.
10.1101/2025.05.27.656200 — cell biology — Posted on 2025-06-04
2008 JADE family proteins regulate proteasome abundance and activity
Ebert, L. K.; Bargfrede, S.; Bohl, K.; Cohen, H.; Mueller, R.-U.; Benzing, T.; Schermer, B.
10.1101/2021.10.01.462752 — cell biology — Posted on 2025-06-04
2010 Cytokine expression profile in the human brain of older adults
Godoy, J. B.; Vialle, R. A.; dos Santos, L.; Raittz, R. T.; Wang, Y.; Menon, V.; De Jager, P.; Schneider, J. A.; Tasaki, S.; Bennett, D. A.; Guizelini, D.; Lopes, K.
10.1101/2025.06.02.657444 — molecular biology — Posted on 2025-06-04
2011 Focused ultrasound neuromodulation of mediodorsal thalamus disrupts decision flexibility during reward learning
Mackenzie, G.; Gilmour, W.; Yang, S. S.; Suveges, S.; MacFarlane, J.; Kanodia, A.; Manfield, J.; Khan, S.; Osman-Farah, J.; Marcerolo, A.; Steele, D.; Gilbertson, T.
10.1101/2025.06.03.657634 — neuroscience — Posted on 2025-06-04
2013 Dendritic computation for rule-based flexible categorization
Xu, N.-l.; Zhang, Y.; Hu, Y.; Zhang, Z.; Du, J.; Cui, L.; Liu, Q.; Zhong, L.; Xin, Y.; Chai, R.; Deng, L.; Pan, J.; Schiller, J.
10.1101/2025.06.03.657766 — neuroscience — Posted on 2025-06-04
2015 PANDA: A simple and affordable chamber system for measuring the whole-plant net CO2 flux
Schuler, P.; Li, Y.; Pittet, P.; Favre, P.; Li, M.-H.; Zhang, Y.-L.; Grossiord, C.
10.1101/2025.06.02.657330 — plant biology — Posted on 2025-06-04
2016 Loss of UFMylation supports prostate cancer metastasis and rewires cell metabolism towards hexosamine biosynthesis
Bozal Basterra, L.; Salazar Palacio, M. C.; Ferreira Campos, A. M.; Demicco, M.; Schmidt, D. R.; Sobczak, K.; Ereno-Orbea, J.; Altea Manzano, P.; Miranda Villanueva, A.; Martinez La Osa, B.; Garcia-Longarte, S.; Ponce Rodriguez, M.; Mendizabal, I.; Carlevaris Lopez, O.; Astobiza, I.; Martin Martin, N.; Zabala-Letona, A.; Talamillo, A.; Fernandez Garcia, J.; Azkargorta, M.; Iloro, I.; Barrio, R.; Elortza, F.; Fendt, S. M.; Vander Heiden, M. G.; Jimenez Barbero, J.; D. Sutherland, J.; Carracedo, A.
10.1101/2025.06.02.657324 — cancer biology — Posted on 2025-06-04
2017 Data-driven symbolic regression reveals microbial growth laws
Sun, T. A.; Kiciatovas, D.; Aapalampi, I.-K.; Kuosmanen, T.; Hiltunen, T.; Mustonen, V.
10.1101/2025.06.02.657040 — ecology — Posted on 2025-06-04
2018 A new resource of clonal pluripotent human stem cell lines exhibiting inter- and intra-embryo consistency and variability
Strawbridge, S. E.; Bates, L. E.; Ross, C.; Jones, K. A.; Azami, T.; Lohoff, T.; Paramor, M.; Murray, V.; Cidral, A. L.; Clarke, J.; Rostovskaya, M.; Guo, G.; Nichols, J.
10.1101/2025.06.02.657331 — developmental biology — Posted on 2025-06-04
2020 Towards Unified Neural Decoding with Brain Functional Network Modeling
Wu, D.; Bu, L.; Jia, Y.; Cao, L.; Li, S.; Zhou, Y.; Fan, S.; Ren, W.; Wu, D.; Wang, K.; Zhang, Y.; Ma, Y.; Yang, J.; Mohamad, S.
10.1101/2025.06.02.657011 — neuroscience — Posted on 2025-06-04
2022 NF-κB is a Central Regulator of Hypoxia-Induced Gene Expression
Shakir, D.; Batie, M.; Kwok, C.-S.; Cook, S. J.; Kenneth, N. S.; Rocha, S.
10.1101/2025.01.08.631917 — molecular biology — Posted on 2025-06-04
2023 RNAi epimutations conferring antifungal drug resistance are inheritable
Perez-Arques, C.; Navarro-Mendoza, M. I.; Xu, Z.; Walther, G.; Heitman, J.
10.1101/2024.10.15.618540 — microbiology — Posted on 2025-06-04
2026 Single-cell morphological profiling reveals insights into programmed cell death
Frey, B.; Holmberg, D.; Bystrom, P.; Bergman, E.; Georgiev, P.; Johansson, M. M.; Hennig, P.; Rietdijk, J.; Rosen, D.; Carreras-Puigvert, J.; Spjuth, O.
10.1101/2025.01.15.633042 — bioinformatics — Posted on 2025-06-04
2027 Population-scale inheritance analysis of 858,635 individuals reveals North Sea migration from the Middle Ages to the Industrial Revolution
Zhang, X.; Holm, P.; Scally, A.; Banasik, K.; Mortensen, L. H.; Fitzgerald, T. W.; Westergaard, D.; Chmura, P. J.; Ostrowski, S. R.; Sorensen, E.; Pedersen, O. B. V.; Schwinn, M.; Erikstrup, C.; Bruun, M. T.; Jensen, B. A.; Ullum, H.; Mikkelsen, C.; Hansen, T. F.; DBDS Genetic Consortium, ; Stefansson, K.; Brunak, S.; Birney, E.
10.1101/2025.03.19.643007 — genetics — Posted on 2025-06-04
2029 PROTRIDER: Protein abundance outlier detection from mass spectrometry-based proteomics data with a conditional autoencoder
Klaproth-Andrade, D.; Scheller, I.; Tsitsiridis, G.; Loipfinger, S.; Mertes, C.; Smirnov, D.; Prokisch, H.; Yepez, V.; Gagneur, J.
10.1101/2025.02.01.636024 — bioinformatics — Posted on 2025-06-04
2031 Aedes albopictus is rapidly invading its climatic niche in France: wider implications for biting nuisance and arbovirus control in Western Europe
Radici, A.; Hammami, P.; Cannet, A.; L'Ambert, G.; Lacour, G.; Fournet, F.; Garros, C.; Guis, H.; Fontenille, D.; Caminade, C.
10.1101/2025.02.14.638223 — ecology — Posted on 2025-06-04
2034 OPM quantum sensors enhance non-invasive neuroimaging performance
Brickwedde, M.; Anders, P.; Krueger, P.; Sander, T.; Uhlhaas, P.
10.1101/2025.05.30.657044 — neuroscience — Posted on 2025-06-04
2035 Valence of sensory stimulation as a key feature for subcortical entrainment: Insights from human intracranial EEG
Hoyer, R. S.; Bernier, M.-F.; Martineau, L.; Lessard Bonaventure, P.; Labelle, C.; Borderie, A.; Blanchette, I.; Blumenthal, A.; Laureys, S.; Albouy, P.
10.1101/2025.01.03.631218 — neuroscience — Posted on 2025-06-04
2038 Butterfly wing iridescence is regulated by araucan, a direct target of Optix and Spalt
Chatterjee, M.; Finet, C.; Siegel, K. J.; Loh, L. S.; Delgado, S.; McDonald, J. M. C.; Markenscoff-Papadimitriou, E.; Monteiro, A.; Reed, R. D.
10.1101/2023.11.21.568172 — genetics — Posted on 2025-06-03
2041 Human brain network control of creativity
Rabinovich, R.; Cowan, R. L.; Libowitz, M.; Davis, T.; Rahimpour, S.; Beaty, R.; Bartoli, E.; Sheth, S.; Smith, E. H.; Shofty, B.
10.1101/2025.06.03.657648 — neuroscience — Posted on 2025-06-03
2043 Spatiotemporal Dynamics of Invariant Face Representations in the Human Brain
Giri, A.; Smith, G.; Manting, C. L.; Dobs, K.; Adler, A.; Pantazis, D.
10.1101/2025.06.03.657646 — neuroscience — Posted on 2025-06-03
2046 Enzyme Activity Regulates Substrate Diffusion by Modulating Viscosity in Crowded Milieu
Bevilacqua, A.; Maciel, M. R.; Sullivan, M. V.; Pascarelli, S.; Dindo, M.; Shen, A. Q.; Laurino, P.
10.1101/2024.09.28.615560 — biochemistry — Posted on 2025-06-03
2048 The Balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells
Zach, R.; Annis, M.; Martin-Guerrero, S. M.; Alatawi, A.; Chia, K. H.; Meredith, M.; Osborn, K.; Peter, N.; Pearce, W.; Booth, J.; Rajasekaran, M.; Dias, S.; Coleman-Evans, L.; Foster, W. R.; Harper, J. A.; Herbert, A. D.; Tighe, C.; Reuillon, T.; West, R.; Busby, O.; Burdova, K.; Crepin, D.; Ortoll, S.; Vaeteewoottacharn, K.; Dejsuphong, D.; Spencer, J.; Patel, H.; Le Grand, D.; Hunt, T. A.; Andrews, D. M.; Yamano, H.; Cutillas, P. R.; Oliver, A. W.; Ward, S. E.; Hochegger, H.
10.1101/2025.06.02.657035 — cell biology — Posted on 2025-06-03
2050 Orderly mitosis shapes interphase genome organization
Guin, K.; Keikhosravi, A.; Chari, R.; Pegoraro, G.; Misteli, T.
10.1101/2025.06.03.657645 — cell biology — Posted on 2025-06-03
2051 Lost in communication: How Mueller glia cells fail to maintain retinal integrity in USH1C retinal organoids
Wenck, N.; Zorin, M.; Wang, Q.; Kroell, S.; Hay, K.; Rickert, C.; Mendez-Lago, M.; Karunanithi, S.; Athanasiou, D.; Ziaka, K.; De Angeli, P.; Stingl, K.; Kohl, S.; Cheetham, M. E.; Mittmann, T.; Nagel-Wolfrum, K.
10.1101/2025.06.03.657614 — cell biology — Posted on 2025-06-03
2052 Pharmacological targeting of SOS1-RAS interaction triggers pancreatic β-cell proliferation and sustainably reverses diabetic hyperglycemia
Papadimitropoulou, A.; Charalampous, C.; Kogionou, P.; Reinhardt, D.; Sonntag, J.; Gavalas, A.; Hofmann, M. H.; Erlmann, P.; Franti, M.; Doerr, J.; Klein, T.; Willis, G. R.; Serafimidis, I.
10.1101/2025.06.03.657628 — cell biology — Posted on 2025-06-03
2053 Translation-specific disruption of Col1a1 expression in multiple models of Spinal Muscular Atrophy can be rescued by Risdiplam.
Sharma, G.; Paganin, M.; Huang, N.; Perenthaler, E.; Signoria, I.; Faller, K.; Maniscalco, F.; Perrucci, C.; Donzel, D.; Chaytow, H.; Basso, M.; Lauria, F.; Kothary, R.; Van Der Pol, L.; Claus, P.; Groen, E. J.; Gillingwater, T. H.; Viero, G.
10.1101/2025.06.03.657600 — molecular biology — Posted on 2025-06-03
2054 Multi-Omic Profiling Identifies Conserved Metabolic Pathways Critical for SARS-CoV-2 Variants Infection
Farley, S. E.; Kyle, J. E.; Jahn, H.; Bramer, L.; Piehowski, P.; Shepmoes, A.; Kaiser, B. L.; Williams, S. M.; Eder, J. G.; Schultz, C.; Tafesse, F.
10.1101/2025.06.02.657371 — systems biology — Posted on 2025-06-03
2055 Dietary zinc restriction induces irreversible allodynia in adult mice
Matias, D. O.; Santos, B. L. R.; Martins, A. F.; Souza, L. P.; Miranda-Alves, L.; Cardoso, L. E. M.; Miranda, A. L. P.; Lima, L. M. T.
10.1101/2025.06.02.657430 — biochemistry — Posted on 2025-06-03
2056 CTx001 for geographic atrophy: a gene therapy expressing soluble, truncated complement receptor 1 (mini-CR1)
Rathi, S.; Didangelos, A.; Pisarenka, S.; Green, R.; Emery-billcliff, P.; Patel, N.; Whalley, P.; Zamira, P.; Tilakaratna, V.; Szula, E.; Hasan, R.; Munye, M.; Unwin, R.; Bishop, P.; Keefe, D.; Clark, S. J.
10.1101/2025.06.03.657557 — biochemistry — Posted on 2025-06-03
2059 Linker Histone H1.5 Contributes to Centromere Integrity in Human Cells
Saha, A.; Bui, M.; Melters, D. P.; Ganesan, A. K.; Baek, S.; Bentahar, R. S.; Dalal, Y.
10.1101/2025.06.03.657682 — biochemistry — Posted on 2025-06-03
2061 An Antibody Cocktail-Based Immunoaffinity-LC-MS Method Enabled Ultra-Sensitive and Robust Quantification of Circulating Proinsulin Proteoforms and C-peptide
Shen, Q.; Cao, W.; Zhang, M.; Lin, T.; Shi, T.; nierves, l.; Evans-Molina, C.; Peterman, s.; boeser, c.; Sims, E. K.; Monaco, G.; QIAN, W.-J.; Qu, J.
10.1101/2025.06.02.657397 — biochemistry — Posted on 2025-06-03
2064 Structure of the energy converting methyltransferase (Mtr) of Methanosarcina mazei in complex with an oxygen-stress responsive small protein
Reif-Trauttmansdorff, T.; Herdering, E.; Bohn, S.; Pascoa, T.; Kahnt, J.; Zimmer, E.; Kumar, A.; Schmitz, R. A.; Schuller, J. M.
10.1101/2025.06.02.657420 — biochemistry — Posted on 2025-06-03
2068 Genomic factors contributing to the resilience of Salmonella enterica on ready-to-eat muskmelon
Esteban Cuesta, I.; Führer, L.; Porwollik, S.; Chu, W.; Fiddaman, S. R.; Sah, I.; McClelland, M.; Guldimann, C.
10.1101/2025.06.02.657348 — genomics — Posted on 2025-06-03
2070 An intergenerational lipid memory of the social environment in C. elegans
Wilhelm, T.; Chen, W.-W.; Wenzel, A.; Tang, W.; Cicerone, M. T.; Lehner, B.
10.1101/2025.06.03.657568 — genetics — Posted on 2025-06-03
2071 In vitro plasticity between ureteric epithelial and distal nephron identity and maturity is controlled by extracellular signals.
Kairath, P.; Er, P. X.; Wilson, S. B.; Ghobrial, I. T.; Vanslambrouck, J. M.; Chen, Y.-H.; Pruett-Miller, S. M.; Jain, S.; Little, M. H.
10.1101/2025.06.03.657609 — developmental biology — Posted on 2025-06-03
2072 Single cell multiomic analysis of the impact of Delta-9-tetrahydrocannabinol on HIV infected CD4 T cells
Ashokkumar, M.; Ge, R. Y.; Cooper-Volkheimer, A.; Margolis, D.; Li, Q.; Jiang, Y.; Murdoch, D. M.; Browne, E. P.
10.1101/2025.06.02.657468 — molecular biology — Posted on 2025-06-03
2073 Zika virus reprograms the host tRNA epitranscriptome to adapt translation to A-ending codon bias
ELDIN, P.; BERNARD, E.; VAGBO, C.; GEORGE, L.; AJIRO, M.; HAGIWARA, M.; SLUPPHAUG, G.; BRIANT, L.
10.1101/2025.06.03.657606 — microbiology — Posted on 2025-06-03
2074 A conserved glycan motif overcomes antigenic variation inducing broadly reactive antibodies against the zoonotic pathogen Streptococcus suis
Shi, Y.; Widmalm, G.; Sorieul, C.; Roodsant, T. J.; Rush, J. S.; Korotkova, N.; Jacobs, A. A. C.; Spaninks, M.; Grommen, R.; Dominguez-Medina, C. C.; Schimmel, I. M.; van der Wel, N. N.; Kenner, C. W.; Heiss, C.; Azadi, P.; Tan, L.; Codee, J. D. C.; Stegeman, A.; Schultsz, C.; Benedictus, L.; van Sorge, N. M.
10.1101/2025.06.02.656523 — microbiology — Posted on 2025-06-03
2076 Global Landscape of Human Kinase Motifs in Viral Proteomes
Alba, K.; Winters, D. M.; Makanani, S. K.; Kaushal, P.; Delgado, Y.; Ashley, I. A.; Sharma, S.; Blanc, S. F.; Kim, E.; Yaron, T.; Johnson, J. L.; Selby, J.; Hur, M.; Ni, J.; Nguyen, J.; Brent, M. H.; Yip, E.; Kassem, A.; Wohlschlegel, J.; Fregoso, O. I.; Wu, T.-T.; Li, M. M.; Bouhaddou, M.
10.1101/2025.06.02.657064 — microbiology — Posted on 2025-06-03
2077 Global proteomic analysis of Cryptococcus neoformans clinical strains reveals significant differences between latent and lethal infection
Betancourt, J. J.; McAlister, J. A.; Perez, J. M.; Meya, D. B.; Thomas, S. N.; Geddes-McAlister, J.; Nielsen, K.
10.1101/2025.06.03.657666 — microbiology — Posted on 2025-06-03
2080 The Role of SARS-CoV-2 Nucleocapsid Protein Persistence in Inducing Chronic Type I Interferon and Mitochondrial Dysfunction.
Koenig, A.; Quasem, M.; Zink, B.; Abdulla-Zoda, D.; Karunanidhi, P.; Sienko, K.; Geier, C.; Jayaraman, V.; Malik, R.; Ahmed, K.; Shanley, P. F.; Koenig, I. A.
10.1101/2025.06.02.657400 — immunology — Posted on 2025-06-03
2081 A histidine switch regulates pH-dependent filament formation by the caspase-9 CARD
Rawal, S.; Kolaric, Đesika; Bohn, S.; Kolb, D.; Pavkov-Keller, T.; Pritisanac, I.; Madl, T.; Desfosses, A.; Alderson, T. R.
10.1101/2025.06.02.657148 — biophysics — Posted on 2025-06-03
2082 Thermally activated irreversible homogenization of G-quadruplexes in an ALS/FTD-associated nucleotide expansion
Ross, D.; Lewis, O.; McLean, O.; Bhanot, S.; Donahue, S.; Baker, R.; Dias, R.; Eagerton, D.; Mohanty, V.; Mohanty, B. K.
10.1101/2025.06.02.657482 — biophysics — Posted on 2025-06-03
2085 Adhesive implant interfaces prevent fibrosis by disrupting mechanobiological feedback
Jafari, M.; Aymon, B.; Hong, Y.; Shakiba, D.; Genin, G. M.; Zhao, X.; Alisafaei, F.
10.1101/2025.06.01.657311 — biophysics — Posted on 2025-06-03
2087 Self-Assembled siRNA-Gold Supraclusters Detected at the Single-Molecule Level in the NIR-II Window
Ayed, Z.; Martin Munoz, B.; Vandekerckhove, C. I.; Faure, V.; Ali, S. N. S.; Coll, J.-L.; Cognet, L.; Le Guevel, X.
10.1101/2025.06.01.657319 — bioengineering — Posted on 2025-06-03
2092 Evolution of genotypic and phenotypic diversity in multispecies biofilms
Amador, C. I.; Moskovitz, S. Z.; Maccario, L.; Herschend, J.; Kramer, I. S.; Jeckel, H.; Cooper, V. S.; Drescher, K.; Neu, T. R.; Burmolle, M.; Roder, H. L.
10.1101/2023.10.08.561388 — microbiology — Posted on 2025-06-03
2096 NeuID, a novel neuron-specific lncRNA, resolved a key epigenetic mechanisms linking gene silencing to Alzheimer's disease
Pradhan, R.; Petrovic, Z.; Sakib, M. S.; Schroeder, S.; Krueger, D. M.; Pena, T.; Diniz, E.; Burkhardt, S.; Schuetz, A.-L.; Grz_dzielewska, I.; Toischer, K.; Stein, T. D.; Blusztajn, J. K.; Delalle, I.; Radulovic, J.; Sananbenesi, F.; Fischer, A.
10.1101/2025.06.01.657217 — neuroscience — Posted on 2025-06-03
2099 Novel mouse model reveals neurodevelopmental origin of PMM2-CDG brain pathology
Edmondson, A. C.; Budhraja, R.; Xia, Z.; Melendez-Perez, A.; Cai, C.; Radenkovic, S.; Collins, A.; Shiplett, E.; Hill, S. F.; Somarowthu, A.; Dam, J.; Pai, L.-L.; Santi, M.; Kim, S.; He, M.; Goldberg, E.; Kozicz, T.; Morava, E.; Pandey, A.; Zhou, Z.
10.1101/2025.06.01.657261 — neuroscience — Posted on 2025-06-03
2103 Evolving resistance patterns in Tetranychus urticae and Bemisia tabaci in Greece
Kampouraki, A.; Ilias, A.; Papapostolou, K.-M.; Malliaraki, S.; Pyrgianakis, I.; Karakosta, E.; Vontas, J.; Tsagkarakou, A.; Mavridis, K.
10.1101/2025.05.31.656940 — pharmacology and toxicology — Posted on 2025-06-03
2104 Lack of synergy between AR targeted therapies and PARP inhibitors in homologous recombination-proficient prostate cancer
Traphagen, N. A.; Wheeler, E.; Li, R.; Lu, F.; Ahmed, B.; Tewari, A. K.; Balk, S. P.; Nelson, P. S.; Corey, E.; Long, H.; D'Andrea, A. D.; Qiu, X.; Brown, M.
10.1101/2025.06.02.657429 — cancer biology — Posted on 2025-06-03
2105 The mutational landscape defines the proteome and spatial organization of tumor, stroma and immune cells in ovarian cancer
Dabke, K.; Gull, N.; Kreimer, S.; Peng, P.-C.; Diaz, M.; Cheikh, B. B.; Dhawan, A.; Evans, K.; Ng, N.; Yuan, X.; Rimel, B.; Li, A. J.; Karlan, B. Y.; Knott, S. V.; Gayther, S. A.; Parker, S. J.; Jones, M. R.
10.1101/2025.06.01.655822 — cancer biology — Posted on 2025-06-03
2106 Targeting HMGA1-driven leukemic transformation in myeloproliferative neoplasms with pacritinib
Yang, C.; Li, Y.; Chen, K.; Tang, X.; Zhang, Q.; Qin, W.; Fu, J.; Zeng, Y.; Ma, X.; Zheng, W.; Huang, Z.; Zhang, W.; Tang, G.; Guan, M.; Wu, Z.
10.1101/2025.06.01.657170 — cancer biology — Posted on 2025-06-03
2108 Non-Invasive Mechanical-Functional Analysis of Individual Liver Mitochondria by Atomic Force Microscopy
Zorikova, E. O.; Chourasia, S.; Rosenhek-Goldian, I.; Cohen, S. R.; Nesterov, S. V.; Gross, A.
10.1101/2025.06.01.657242 — biophysics — Posted on 2025-06-03
2113 Desmoplakin Haploinsufficiency Underlies Cell-Cell Adhesion Failure in DSP Cardiomyopathy and is Rescued by Transcriptional Activation
Smith, E. D.; Jin, K.; Ferguson, B.; Tsan, Y.-C.; DePalma, S. J.; Meisner, J. K.; Renberg, A.; Bedi, K.; Friedline, S.; Margulies, K. B.; Baker, B. M.; Helms, A. S.
10.1101/2025.06.01.657304 — genetics — Posted on 2025-06-03
2115 A method for creating custom 3D-printed molds to facilitate zebrafish imaging studies, including of cardiac development.
Miller, J. C.; Koirala, P.; Argote de la Torre, M. F.; Farsi, M.; Lieberth, J.; Shrestha, R.; Bloomekatz, J.
10.1101/2025.06.01.657246 — developmental biology — Posted on 2025-06-03
2116 prdm1a drives a fate switch between hair cells of different mechanosensory organs
Sandler, J.; Tsai, Y.-Y.; Chen, S.; Sabin, L.; Lush, M.; Sur, A.; Ellis, E.; Tran, N. T. T.; Cook, M.; Scott, A. R.; Kniss, J. S.; Farrell, J. A.; Piotrowski, T.
10.1101/2025.06.01.657251 — developmental biology — Posted on 2025-06-03
2119 Novel Adomaviruses Associated with Blotchy Bass Syndrome in Black Basses (Micropterus spp.)
Iwanowicz, L.; Raines, C.; Young, K.; Blazer, V.; Walsh, H.; Smith, G.; Holt, C.; Odenkirk, J.; Jones, T.; Hessenauer, J.-M.; Biggs, M.; Buck, C.; Greer, J.; Cornman, R. S.
10.1101/2025.06.01.657292 — microbiology — Posted on 2025-06-03
2120 ACOD1 regulates microglial arginine metabolism and inflammatory responses
Karadima, E.; Yilmaz, C.; Sinha, A.; Fodelianaki, G.; Dimothyra, S.; Nirakis, N.; Traikov, S.; Zamboni, N.; Wielockx, B.; Verginis, P.; Peitzsch, M.; Chavakis, T.; Alexaki, V. I.
10.1101/2025.06.01.657243 — immunology — Posted on 2025-06-03
2121 Diverse modes of T cell receptor sequence convergence define unique functional and cellular phenotypes
Schattgen, S.; Vegesana, K.; Hazelton, W. D.; Minervina, A.; Valkiers, S.; Slowikowski, K.; Smith, N. P.; MGH COVID-19 Team, ; Villani, A.-C.; Thomas, P. G.; Bradley, P.
10.1101/2025.05.31.657155 — immunology — Posted on 2025-06-03
2124 Direct Binding of FGFR3 Autoantibodies to Sensory Neurons Drives Hyperexcitability and Mechanical Hypersensitivity
Salih, L. Y.; Dumaire, N. L.; Vest, E.; Alkhateeb, H.; Moritz, C. P.; Tholance, Y.; Camdessanche, J.-P.; Antoine, J.-c.; Honnorat, J.; Kafaie, J.; francois-Moutal, L.; Moutal, A.
10.1101/2025.06.01.657230 — neuroscience — Posted on 2025-06-03
2126 A characterization of mouse retinal ganglion cell types labeled with AAV tools
Son, S.; Beaudoin, D. L.; Hassan, A. R.; Akpo, M. S.; Ichinose, T.; Garrett, A. M.
10.1101/2025.06.02.657062 — neuroscience — Posted on 2025-06-03
2131 Resistance to Atrial Fibrillation Domestication and Mitochondrial Dysfunction in Sheep: a potential key role of the TCA Cycle and mitochondrial redox state
Caluori, G.; Nattel, S.; Pinson, B.; Naud, P.; Beauvoit, B.; Claverol, S.; Vaillant, F.; Charron, S.; Guilloteau, F.; Loyer, V.; Constantin, M.; Popa, M.; Belykh, A.; Haeberlin, A.; Ploux, S.; Mahamat, H. A.; Dubois, R.; Guillot, B.; Krisai, P.; Kamakura, T.; Bernus, O.; Jais, P.; Dos Santos, P.; Pasdois, P.
10.1101/2025.06.01.657249 — pathology — Posted on 2025-06-03
2132 Multimodal imaging reveals a lysosomal drug reservoir that drives heterogeneous distribution of PARP inhibitors
Moncayo, C. R.; Restuadi, R.; Zhang, G.; Marks, D.; Ortega-Prieto, P.; Doherty, E.; Lambie, N.; Whilding, C.; Andrew, I.; Montoya, A.; Patel, B.; Pennycook, B. R.; Wu, V.; Takats, Z.; Matthews, N.; Young, G. R.; Shliaha, P.; Game, L.; Lenhard, B.; McNeish, I.; Fotopoulou, C.; Barr, A. R.; Cunnea, P.; Hall, Z.; Fets, L.
10.1101/2025.05.31.656628 — cancer biology — Posted on 2025-06-03
2137 Competing Subclones and Fitness Diversity Shape Tumor Evolution Across Cancer Types
Chen, H.; Shu, J.; Mudappathi, R.; Li, E.; Wang, P.; Bergsagel, L.; Yang, P.; Sun, Z.; Zhao, L.; Shi, C.; Townsend, J. P.; Maley, C.; Liu, L.
10.1101/2025.05.31.657191 — bioinformatics — Posted on 2025-06-03
2139 DeepLC introduces transfer learning for accurate LC retention time prediction and adaptation to substantially different modifications and setups
Bouwmeester, R.; Nameni, A.; Declercq, A.; Devreese, R.; Velghe, K.; Gorshkov, V.; Penanes, P. A.; Kjeldsen, F.; Rompais, M.; CARAPITO, C.; Gabriels, R.; Martens, L.
10.1101/2025.06.01.657225 — bioinformatics — Posted on 2025-06-03
2140 scVIVA: a probabilistic framework for representation of cells and their environments in spatial transcriptomics
Levy, N.; Ingelfinger, F.; Bakulin, A.; Cinnirella, G.; Boyeau, P.; Nadler, B.; Ergen, C.; Yosef, N.
10.1101/2025.06.01.657182 — bioinformatics — Posted on 2025-06-03
2141 BifurcatoR: A Framework for Revealing Clinically Actionable Signal in Variance Masquerading as Noise
Madaj, Z. B.; Ding, M.; Khoo, C. K.; Tokarski, E.; Fagnocchi, L.; PERMUTE, ; Li, Z.; Riordan, J.; Pospisilik, J. A.; Nadeau, J.; Lary, C.; Triche, T. J.
10.1101/2025.06.01.657083 — bioinformatics — Posted on 2025-06-03
2143 A Set of Novel Far-Red Fluorescent Proteins for Temporal Domain Multiplexing and Super-Resolution Imaging
Olumayowa, F.; Rong, Z.; Wang, R.; Papadaki, S.; Wang, X.; Cao, J.; Subach, F. V.; Koster, R. W.; Namikawa, K.; Piatkevich, K. D.
10.1101/2025.06.01.657196 — biochemistry — Posted on 2025-06-03
2146 A Single-cell and Spatially Resolved Cell Atlas of Human Esophageal Squamous Cell Carcinoma
shi, y.; An, K.; Qi, Y.; Zhang, X.; Wang, Y.; Zhang, X.; Zhou, S.; Li, O.; Zhou, J.; Du, Y.; Hou, M.; Yang, Y.-G.; Kan, Q.; Tian, X.
10.1101/2025.06.01.657221 — genomics — Posted on 2025-06-03
2148 Simulation-based spatially explicit close-kin mark-recapture
Patterson, G.; Goodfellow, C. K.; Ting, N.; Kern, A. D.; Ralph, P. L.
10.1101/2025.05.31.656892 — ecology — Posted on 2025-06-03
2149 Transcription factors SP5 and SP8 drive primary cilia formation
Liang, Y.; Koche, R.; Chalamalasetty, R. B.; Stephen, D. N.; Kennedy, M. W.; Lao, Z.; Pang, Y.; Kuo, Y.-Y.; Lee, M.; Lobo, F. P.; Huang, X.; Hadjantonakis, A.-K.; Yamaguchi, T. P.; Anderson, K. V.; Joyner, A. L.
10.1101/2025.06.03.657415 — developmental biology — Posted on 2025-06-03
2152 Structural basis of liver de-targeting and neuronal tropism of CNS-targeted AAV capsids
Brittain, T. J.; Jang, S.; Coughlin, G. M.; Barcelona, B. H.; Giriat, I.; Ristic, F.; Appling, N.; Chossis, C. P.; Shay, T. F.; Gradinaru, V.
10.1101/2025.06.02.655683 — molecular biology — Posted on 2025-06-03
2153 Mobile genetic elements that shape microbial diversity and functions in thawing permafrost soils
Guo, J.; Aroney, S.; Dominguez-Huerta, G.; Smith, D.; Vik, D.; Ansah, C. O.; Pratama, A. A.; Solonenko, S.; Tian, F.; Howard-Varona, C.; Zhong, Z.; Fofana, A.; Smith, G.; Hodgkins, S. B.; Cronin, D.; EMERGE Field Teams 2010-2019, ; EMERGE Coordinators, ; Woodcroft, B. J.; Tyson, G. W.; Rich, V. I.; Sullivan, M. B.; Roux, S.; Bagby, S. C.
10.1101/2025.02.12.637893 — microbiology — Posted on 2025-06-03
2154 Evaluating Best Practices for Isolating Pyrophilous Bacteria and Fungi from Burned Soil
Enright, D. J.; Veerabahu, A.; Quaal, R. J.; Vega, M.; Nguyen, A.; Grindeland, J.; Randolph, J. W. J.; Ordonez, M. E.; Glassman, S. I.
10.1101/2024.09.16.612975 — microbiology — Posted on 2025-06-03
2155 Non-Physiological Potassium Concentrations in Commercial Culture Media Trigger Acute Epileptiform Activity in Human iPSC-Derived Neurons
Lyckenvik, T.; Izsak, J.; Arthursson, E.; Forsberg, M.; Johansson, K.; Zetterberg, H.; Axelsson, M.; Wasling, P.; Theiss, S.; Hanse, E.; Illes, S.
10.1101/2025.05.31.657142 — neuroscience — Posted on 2025-06-03
2156 Social experience alters behaviors by reprogramming the Fruitless pathway and circadian state in Drosophila
Du, C.; Okuwa, S.; Jia, L.; Rozados Barreiro, M.; Scott, S.; Sotelo Fonseca, J. E.; Mabuchi, Y.; Appadoo, S.; Garcia, L.; Rohrbach, S.; Koruk, S.; Balkanli, E.; Lin, J.; Yapici, N.; Jones, C.; Volkan, P.
10.1101/2025.05.30.657129 — neuroscience — Posted on 2025-06-03
2158 Antidepressants reactivate developmental plasticity through remodeling of extracellular matrix
Nguyen, P. T.; Sun, E.; Shi, Y.; Tamura, S.; Xiao, Y.; Lacefield, C.; Turi, G.; Hen, R.
10.1101/2025.01.03.631260 — neuroscience — Posted on 2025-06-03
2160 Sleep loss suppresses the motivation to prepare for sleep
Freitag, N.; El-Tawil, K.; Crane, A.; Hilo, V.; Saad, G.; Eban-Rothschild, A.
10.1101/2025.06.02.657276 — neuroscience — Posted on 2025-06-03
2162 Molecular Subtyping Based on Hippocampal Cryptic Exon Burden Reveals Proteome-wide Changes Associated with TDP-43 Pathology across the Spectrum of LATE and Alzheimer's Disease
Trautwig, A. N.; Shantaraman, A.; Chung, M.; Dammer, E. B.; Ping, L.; Duong, D. M.; Petrucelli, L.; Ward, M. E.; Glass, J. D.; Nelson, P. T.; Levey, A. I.; McEachin, Z. T.; Seyfried, N. T.
10.1101/2025.05.30.656396 — neuroscience — Posted on 2025-06-03
2165 A Solid-Phase Extraction Capture (SPEC) workflow in nanoliter volumes for fast, robust and ultrasensitive proteomics
Heymann, T.; Oliinyk, D.; Henneberg, L.; Rodriguez, E.; Bardziukova, A.; Oeller, M.; Murgia, M.; Olsen, J. V.; Stoychev, S.; Bache, N.; Mann, M.
10.1101/2025.05.31.657165 — systems biology — Posted on 2025-06-03
2166 Expanding salivary biomarker detection by creating a synthetic neuraminic acid sensor via chimeragenesis
Verzino, S. J.; Priyev, S. A.; Sanchez Estrada, V. A.; GholamianMoghaddam, A.; Crowley, G. X.; Rutkowski, A.; Lam, A. C.; Nazginov, E. S.; Kotemelo, P.; Bacelo, A.; Flannery, J. D.; Gavrilov, K.; Sukhram, D. T.; Vazquez, F. X.; Fernandez Juarez, J.
10.1101/2024.06.13.598939 — synthetic biology — Posted on 2025-06-03
2169 Oxidative stress mediates cardiac electrophysiological injury in inhalation exposure to flavored vaping products.
Abou-Assali, O. J.; Reiser, M.; Chang, M.; Chidipi, B.; Asswaytte, R.; Zhang, Y.; Szekeres, C.; Calcul, L.; Noujaim, S. F.
10.1101/2025.05.31.657128 — physiology — Posted on 2025-06-03
2170 Cryo-EM structure of DNA-unbound human MCM2-7 complex reveals new disease-relevant regulation
Liu, Y.; Yang, M.; Lu, P.; Gao, H.; He, M.; Wang, Y.; Qi, A.; Cao, T.; Zhang, Q.; Qi, S.; Shi, Y.; Yu, H.
10.1101/2025.05.31.656953 — biophysics — Posted on 2025-06-03
2173 A parallelly distributed microscope and software system for scalable high-throughput multispectral 3D imaging
Jiang, H.; Walker, L. A.; Li, Y.; Duan, B.; Niu, X.; Hsieh, J.-C.; Cheng, M.-C.; Su, H.; Sheng, K.; Tang, J. P.; Athukorala, K.; Greene, S.; Pan, R.; Parlapalli, A.; Yin, P.; Cui, M.; Cai, D.
10.1101/2025.05.31.657163 — bioengineering — Posted on 2025-06-03
2178 Clonal Expansion of Alveolar Fibroblast Progeny Drives Pulmonary Fibrosis
Molina, C.; Tsukui, T.; Khan, I.; Ren, X.; Qiu, W.; Matthay, M.; Wolters, P.; Sheppard, D.
10.1101/2025.05.31.657194 — cell biology — Posted on 2025-06-03
2179 Sequence grammar and dynamics of subcellular translation revealed by APEX-Ribo-Seq
Tomuro, K.; Akaiwa, T.; Harada, A.; Kobayashi, K.; Shiina, N.; Kawaguchi, K.; Shichino, Y.; Iwasaki, S.
10.1101/2025.05.26.656194 — molecular biology — Posted on 2025-06-03
2184 Modelling Glomerular Filtration using Multispectral Optoacoustic Tomography and a Novel Near-infrared Dye
Littlewood, J.; Harwood, R.; Vajpayee, S.; Perciaccante, R.; Trivino-Cepeda, K.; Sharkey, J.; Sardella, T.; Burton, N.; Taylor, A.; Wilm, B.; Bearon, R.; Murray, P.
10.1101/2025.05.31.657147 — physiology — Posted on 2025-06-03
2185 Introduction of cytosine-5 DNA methylation sensitizes cells to oxidative damage
Krwawicz, J.; Sheeba, C. J.; Hains, K.; McMahon, T.; Zhang, Y.; Kriaucionis, S.; Sarkies, P.
10.1101/2024.09.13.612259 — molecular biology — Posted on 2025-06-03
2186 Heat-off responses of epidermal cells sensitize Drosophila larvae to noxious inputs
Yoshino, J.; Chiu, A.; Morita, T.; Yin, C.; Tenedini, F. M.; Sokabe, T.; Emoto, K.; Parrish, J. Z.
10.1101/2025.05.30.656957 — neuroscience — Posted on 2025-06-03
2187 A covalent recognition strategy enables conspecific mate identification
Jang, S. S.; Mandala, S.; Jiang, H.; Zhang, X.; Cole, P. A.; del Marmol, J. I.
10.1101/2025.05.30.657074 — neuroscience — Posted on 2025-06-03
2188 Transforming descending input into motor output: An analysis of the Drosophila Male Adult Nerve Cord connectome
Cheong, H. S. J.; Eichler, K.; Stuerner, T.; Asinof, S. K.; Champion, A. S.; Marin, E. C.; Oram, T. B.; Sumathipala, M.; Venkatasubramanian, L.; Namiki, S.; Siwanowicz, I.; Costa, M.; Berg, S.; Janelia FlyEM Project Team, ; Jefferis, G. S. X. E.; Card, G. M.
10.1101/2023.06.07.543976 — neuroscience — Posted on 2025-06-03
2190 Reflected Inline Detection in Epi Oblique Plane Microscopy
Prince, M. N. H.; Muthubharathi, B. C.; Herath, W.; Sain, N.; Rupam, M. R. I.; Bhat, A. Q.; Wani, A. R.; Syed, M. H.; Kim, T.-H.; Walker, M. C.; Ponomarova, O.; Chakraborty, T.
10.1101/2025.05.30.657110 — biophysics — Posted on 2025-06-03
2192 Risk evaluation of newly emerging flu viruses based on genomic sequences and AI
Li, H.; Feng, Y.; Lu, C.; Fu, P.; Wang, X.; Yang, L.; Shu, Y.; Jiang, T.; Wang, D.; Peng, Y.
10.1101/2025.04.18.649608 — bioinformatics — Posted on 2025-06-03
2193 Species interactions determine plasmid persistence in a 3-member bacterial community
Schaal, K. A.; Wang, Y.-J.; Nauta, J.; Pilosof, S. A.; De Domenico, M.; Hall, J. P.
10.1101/2025.05.31.657151 — ecology — Posted on 2025-06-03
2194 Two birds with one stone: a novel potential antibiotic blocking IsdB-mediated heme extraction by Staphylococcus aureus with serendipitous hemoglobin left-shifting activity
Hijazi, S.; Marchesani, F.; Marchetti, M.; Buoli Comani, V.; Brear, P.; Campanini, B.; Ronda, L.; Faggiano, S.; Gianquinto, E.; Asgharpour Hassankiadeh, S.; Rolando, B.; Spyrakis, F.; Compari, C.; Lazzarato, L.; De Bei, O.; Frangipani, E.; Bettati, S.
10.1101/2025.05.29.656759 — microbiology — Posted on 2025-06-03
2196 Multivariate pattern analysis reveals resting-state EEG biomarkers in fibromyalgia
Soldic, D.; Martin-Buro, M. C.; Lopez-Garcia, D.; del Pino, A. B.; Fernandes-Magalhaes, R.; Ferrera, D.; Pelaez, I.; Mercado Romero, F.
10.1101/2025.05.30.657056 — neuroscience — Posted on 2025-06-03
2197 Normalization of Prefrontal Network Dynamics Prevents Cognitive Impairments After Developmental Insult
Khalife, M. R.; Jasinski, P.; Abed Rabbo, K.; Ouardouz, M.; Mahoney, J. M.; Scott, R.; Hernan, A.
10.1101/2025.05.30.657069 — neuroscience — Posted on 2025-06-03
2198 Detection of astrocyte epigenetic memory in in vitro systems, experimental autoimmune encephalomyelitis and multiple sclerosis samples
Quintana, F. J.; Li, Z.; Faust Akl, C.; Lee, J.-H.; Piester, G.; Antel, J.; Rothhammer, V.; Wheeler, M. A.; Prat, A.; Clark, I. C.
10.1101/2025.05.30.657119 — neuroscience — Posted on 2025-06-03
2199 Bright and Photostable Voltage Sensors Derived from mBaoJin
Zhang, H.; Zhou, S.; Kuzmicheva, T. P.; Subach, O. M.; Grimm, C.; Eom, M.; Baror-Sebban, S.; Adam, Y.; Yoon, Y.-G.; Emilliani, V.; Subach, F. V.; Piatkevich, K. D.
10.1101/2025.05.30.657123 — neuroscience — Posted on 2025-06-03
2200 Structural and Mechanistic Insights into Symmetry Conversion in Plant GORK K+ Channel Regulation
Li, Q.-y.; Qin, L.; Tang, L.-h.; Zhang, C.-r.; Huang, S.; Wang, K.; Zhang, G.-h.; Hao, N.-j.; Xiao, Q.; Niu, T.-X.; Su, M.; Hedrich, R.; Chen, Y.-h.
10.1101/2024.12.17.628833 — plant biology — Posted on 2025-06-03
2203 Adaptive motility enables neutrophils to rapidly navigate confined capillaries
Deygas, M.; Bernard, M.; Nivoit, P.; Barbier, L.; Wang, L.; Maurin, M.; Tejerina, E.; Jakuszeit, T.; Deslys, A.; Garcia-Gomez, M.; Baaziz, O.; Garbay, S.; Terriac, E.; Attia, R.; Dumenil, G.; Piel, M.; VARGAS, P.
10.1101/2025.01.08.631737 — cell biology — Posted on 2025-06-03
2204 Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model
Piatti, L.; Batzilla, A.; Nakaki, F.; Fleckenstein, H.; Korbmacher, F.; Long, R. K. M.; Schraivogel, D.; Hawkins, J. A.; Romero-Urunuela, T.; Lopez-Gutierrez, B.; Sanz, S.; Schwab, Y.; Steinmetz, L. M.; Sharpe, J.; Bernabeu, M.
10.1101/2024.10.15.618439 — microbiology — Posted on 2025-06-03
2207 Hematobiochemical Alterations and Pathological Lesions Induced by Fasciolosis in Slaughtered Cattle at Gondar ELFORA Abattoir, Ethiopia
Temesgen, A. B.; Mitiku, T.; Birhan, M.; Kebede, M. C.; Yesuf, M.; Mekonnen, M. Y.; Alemayehu, M. M.; Malede, B. A.; Geda, A. M.; Tumebo, A. W.; Shiferaw, K. A.; Wassie, Z. G.; Berie, G. K.; Mengistu, B. A.; Feleke, M. G.; Edenshaw, F.; Yitie, M. T.; Kasse, G. E.; Tsehay, E. M.; Shiferaw, S. A.
10.1101/2024.08.10.607441 — pathology — Posted on 2025-06-03
2208 Kinesin-1 Autoinhibition Tunes Cargo Transport by Motor Ensembles
Bensel, B. M.; Previs, S. B.; Fagnant, P. M.; Trybus, K. M.; Walcott, S.; Warshaw, D. M.
10.1101/2025.05.06.652443 — biophysics — Posted on 2025-06-03
2210 DeepPGDB: A Novel Paradigm for AI-Guided Interactive Plant Genomic Database
Li, F.; Chen, J.; Luo, W.; Liu, J.; Hou, Z.; Gan, Z.; Zhan, P.; Wang, Z.; Hu, H.; Chen, G.; Shuai, B.; Zhao, H.; Bi, C.; Wang, S.
10.1101/2025.06.01.657209 — bioinformatics — Posted on 2025-06-03
2211 OPM quantum sensors enhance non-invasive neuroimaging performance
Brickwedde, M.; Anders, P.; Krueger, P.; Sander, T.; Uhlhaas, P.
10.1101/2025.05.30.657044 — neuroscience — Posted on 2025-06-03
2214 The Regulation of COX-2, ABCA1 and ABCG1 by the lncRNA PACERR links the inflammatory response and cholesterol homeostasis
Hennessy, E. J.; Tanosaki, T.; Lordan, R. J.; Tang, S. Y.; Shuvaev, V.; Ghosh, S.; Das, U.; Joshi, R.; Meng, H.; Snouwaert, J. n.; Winter, H.; Maegdefessel, L.; Koller, B. N.; FitzGerald, G. A.
10.1101/2025.06.02.657432 — cell biology — Posted on 2025-06-03
2215 Regulation of reticular adhesions by KANK2 and talin2 in two melanoma cell lines
Rac, A.; Loncaric, M.; Stojanovic, N.; Fatima, M.; Resetar, M.; Hrsak, D.; Humphries, J. D.; Humphries, M. J.; Ambriovic-Ristov, A.
10.1101/2025.06.02.657402 — cell biology — Posted on 2025-06-03
2216 Chlamydial membrane vesicles deliver the chlamydial porin OmpA to mitochondria to inhibit apoptosis
Mesesan, A.; Oehler, H.; Kontchou, C. W.; Haimovici, A.; Helmstädter, M.; Kretz, O.; Schilling, O.; Nazarenko, I.; Matti, U.; Ries, J.; Gentle, I.; Häcker, G.
10.1101/2025.06.02.657351 — cell biology — Posted on 2025-06-03
2221 Assessing plant phenological changes based on drivers of spring phenology
Jiang, Y.; Mayor, S.; Chu, X.; Ye, X.; Man, R.; Tao, J.; Dang, Q.-L.
10.1101/2025.04.13.648654 — ecology — Posted on 2025-06-03
2222 A minimal hybridization capture system for the parallel enrichment and cost-effective detection of ancient human pathogens
Kocher, A.; Seguin-Orlando, A.; Clavel, P.; Louvel, G.; Jonvel, R.; Tzortzis, S.; Signoli, M.; Costedoat, C.; Orlando, L.
10.1101/2025.06.02.657376 — molecular biology — Posted on 2025-06-03
2224 Single-cell spatial map of cis-regulatory elements for disease-related genes in the macaque cortex
Meng, J.; Lei, Y.; Chen, C.; Zhu, Z.; Sun, Y.; Huang, Y.; Hu, K.; Bai, Y.; Fei, T.; Liu, Z.; Li, C.; Shen, Z.; Liu, L.; Li, C.; Song, T.; Liu, C.; Poo, M.; Liu, S.; Sun, Y.
10.1101/2025.06.03.657577 — neuroscience — Posted on 2025-06-03
2225 Visual processing of manipulable objects in the ventral stream is modulated by inputs from parietal action systems
Garcea, F. E.; Strawderman, E.; Burns, W.; Cotroneo, M.; Meyers, S. P.; Schmidt, T.; Walter, K. A.; Pilcher, W. H.; Mahon, B. Z.
10.1101/2025.06.01.657280 — neuroscience — Posted on 2025-06-03
2226 Cysteine signaling in plant pathogen response
Moormann, J.; Heinemann, B.; Angermann, C.; Koprivova, A.; Armbruster, U.; Kopriva, S.; Hildebrandt, T. M.
10.1101/2025.03.13.642987 — plant biology — Posted on 2025-06-03
2227 Action mechanism of a novel agrichemical quinofumelin against Fusarium graminearum
Xiu, Q.; Yin, X.; Chen, Y.; Zhang, Z.; Mao, Y.; Wang, T.; Zhang, J.; Zhou, M.; Duan, Y.
10.1101/2025.01.13.632717 — pathology — Posted on 2025-06-03
2228 Structures of protein folding intermediates on the ribosome
Chan, S. H. S.; Streit, J. O.; Wlodarski, T.; Mitropoulou, A. N.; Cassaignau, A. M. E.; Bukvin, I. V.; Cabrita, L. D.; Christodoulou, J.
10.1101/2025.04.07.647236 — biophysics — Posted on 2025-06-03
2229 EASYstrata: An All-in-One Workflow for Genome Annotation and Genomic Divergence Analysis
Rougemont, Q.; Lucotte, E.; Boyer, L.; Jalaber, A.; Snirc, A.; Giraud, T.; Rodriguez de la Vega, R. C.
10.1101/2025.01.06.631483 — genomics — Posted on 2025-06-03
2230 Use of massive DNA barcoding to monitor biodiversity: a test on forest soil macrofauna
Jabot, F.; Auger, G. B.; Bonnal, P.; Pizaine, M.; Roncoroni, M.; Revaillot, S.; Pottier, J.
10.1101/2025.02.07.636998 — ecology — Posted on 2025-06-03
2231 Dynamical forces drive cell and organ morphology changes during embryonic development
Manna, R. K.; Retzlaff, E. M.; Hinman, A. M.; Lan, Y.; Abdel-Razek, O.; Bates, M.; Hehnly, H.; Amack, J. D.; Manning, M. L.
10.1101/2024.07.13.603371 — developmental biology — Posted on 2025-06-03
2232 Phylogenetic position and mitochondrial genome evolution of 'orphan' eukaryotic lineages
Zlatogursky, V.; Boscaro, V.; Lax, G.; Wanntorp, M.; Pohl, N.; Burki, F.; Keeling, P. J.
10.1101/2025.04.16.649146 — microbiology — Posted on 2025-06-03
2234 Targeting Neutrophil Extracellular Traps to inhibit Colon Cancer Tumor Necrosis and Metastasis
Gazzara, E.; Adrover, J. M.; Lui, A.; Han, S.; Aminzada, Z.; Bhandari, N.; Sivetz, N.; Shirue, V. S.; Shergill, B. S.; Curtis, M. B.; George, S. C.; Cicala, A.; Rishi, A.; Chung, C.; Devoe, C.; Huang, H.; Weiss, M.; Lou, E.; Tuveson, D. A.; Beyaz, S.; Westcott, P. M. K.; Egeblad, M.; Gholami, S.
10.1101/2025.05.30.657122 — cancer biology — Posted on 2025-06-03
2235 A missense mutation in Muc2 promotes gut microbiome- and metabolome-dependent colitis-associated tumorigenesis.
Verna, G.; De Santis, S.; Islam, B.; Sommella, E. M.; Licastro, D.; Zhang, L.; De Almeida Celio, F.; Merciai, F.; Caponigro, V.; Campiglia, P.; Pizarro, T. T.; Chieppa, M.; Cominelli, F.
10.1101/2025.05.31.657160 — cancer biology — Posted on 2025-06-03
2236 Klf4-dependent pivotal role of smooth muscle-derived Gli1+ lineage progenitor cells in lung cancer progression
Lu, S.; Navarro, A. C.; Johnson, A. M.; Noble, T.; Jolly, A. J.; Moulton, K. S.; Nemenoff, R. A.; Weiser-Evans, M. C.
10.1101/2025.05.30.657094 — cancer biology — Posted on 2025-06-03
2237 KOLF2.1J iTF-Microglia: A standardized platform to studymicroglial transcriptional regulatory networks in CNS disease
Rodriguez-Nunez, I.; Bartley, S. C.; Taylor, J. W.; Johnston, S. Q.; Rogers, B. B.; Meadows, S. K.; Newberry, K. M.; Cochran, J. N.; Myers, R. M.
10.1101/2025.05.30.657077 — genomics — Posted on 2025-06-03
2240 WNK1 kinase activity is required for maintenance of podocyte structure
Liu, Z.; Lee, E.; Jiang, S.; Yoon, J.; Ahmed, F.; Rahman, M. A.; Bleicher, W. P.; Suleiman, H. Y.; Bruggeman, L. A.; Miller, R. T.; Chang, A. N.
10.1101/2025.05.30.657136 — cell biology — Posted on 2025-06-03
2241 Spatial Heterogeneity of Macrophages in the Human Lung
Hume, P. S.; Lyn-Kew, K. H.; Wynn, E. A.; Steinhart, B.; Driscoll, J.; Jacobson, S.; Henson, P. M.; Mould, K. J.; Moore, C. M.; Janssen, W. J.
10.1101/2025.05.30.657106 — immunology — Posted on 2025-06-03
2243 VGLL3-centered network connects placental, vascular, and immune defects in preeclampsia
Plazyo, O.; Chopp, L. B.; Peela, R.; Young, K.; Zhang, H.; Bogle, R.; Hesson, A.; Langen, E.; Bergin, I. L.; Syu, L.-J.; Erba, J.; Kirma, J.; Dey, P.; Zhang, L.; Sarkar, M. K.; Swindell, W. R.; Gallagher, K. A.; Ward, N. L.; Singer, K.; Kahlenberg, J. M.; Billi, A. C.; Dlugosz, A. A.; Ganesh, S. K.; Tsoi, L. C.; Gudjonsson, J. E.
10.1101/2025.05.30.657097 — immunology — Posted on 2025-06-03
2246 DNA-based delivery of incretin receptor agonists using MYO Technology leads to durable weight loss in a diet-induced obesity model
Sasset, L.; Cameron, A. D.; Sussman, C.; Rubinelli, L.; Maji, D.; Miller, R.; Thompson, A. T.; Campbell, D.; Walker, M. R.; Drozdz, M. M.; Liberatore, R. A.
10.1101/2025.05.30.656889 — physiology — Posted on 2025-06-03
2248 A network medicine framework for multi-modal data integration in therapeutic target discovery
Baltusyte, G.; Toleman, I.; Jones, J.; Welsh, S. J.; Stewart, G. D.; Mitchell, T. J.; Saeb-Parsy, K.; Han, N.
10.1101/2025.05.29.656813 — bioinformatics — Posted on 2025-06-03
2253 Turbulence orchestrates actin-mitochondria dynamics to preserve GPIbα and support iPSC-derived platelet biogenesis
Nakamura, E.; Harada, Y.; Nakamura, S.; Fujio, K.; De Wispelaere, K.; Thys, C.; Freson, K.; Yamamoto, T.; Sawaguchi, A.; Suetsugu, S.; Eto, K.
10.1101/2025.05.22.655481 — cell biology — Posted on 2025-06-03
2254 Circular RNAs accumulate in ageing human placental tissue and in stillbirth, leading to DNA damage and cellular senescence
Arthurs, A. L.; Jackson, M. R.; McCullough, D.; SCOTT, H.; Barnett, C. P.; Webb, S. T.; Smith, M. D.; Jankovic-Karasoulos, T.; Dekker, G. A.; Roberts, C. T.
10.1101/2024.09.02.610398 — molecular biology — Posted on 2025-06-03
2256 Recurrent Emergence of Boundary Cell Types During Evolution of Floral Bullseye Patterns
Oud, S.; Zurowski, M. M.; van der Jagt, P. L.; Yeo, M. T. S.; Walker, J. F.; Moyroud, E.; Vroomans, R. M. A.
10.1101/2025.05.03.651954 — systems biology — Posted on 2025-06-03
2257 The signature of reproduction on wood anatomy in European beech reveals potential for masting reconstruction
Resente, G.; Crivellaro, A.; Fleurot, E.; Piermattei, A.; Maimone, F.; Wilmking, M.; Hacket-Pain, A.; Motta, R.; Ascoli, D.
10.1101/2025.05.27.656364 — plant biology — Posted on 2025-06-03
2259 Enabling Plasmid-based Expression in Clostridium kluyveri using a Biparental Methylation-Conjugation System
Agena, E. M.; Badani, A. A.; Lindner, B. G.; Gois, I. M.; Dempster, A. W.; Minton, N. P.; Mahadevan, R.; Lawson, C. E.
10.1101/2025.05.30.657078 — bioengineering — Posted on 2025-06-03
2262 Increased Genetic Protection Against Alzheimer's Disease in Centenarians
Bae, H.; Song, Z.; Ali, A.; Sasaki, T.; Tesi, N.; Lords, H.; Leshchyk, A.; Abe, Y.; Hirose, N.; Arai, Y.; Barzilai, N.; Weiss, E. F.; Hulsman, M.; van der Lee, S. J.; van Schoor, N. M.; Huisman, M.; Pijnenburg, Y. A. L.; van der Flier, W. M.; Reinders, M.; Holstege, H.; Milman, S.; Perls, T.; Andersen, S. L.; Sebastiani, P.
10.1101/2025.06.02.657442 — genetics — Posted on 2025-06-03
2263 Composition variations in archaeological human bone proteomes
Asmundsdottir, R. D.; Troche, G.; Olsen, J. V.; Schrader, S.; Welker, F.
10.1101/2025.06.02.657369 — evolutionary biology — Posted on 2025-06-03
2264 Purinergic receptor activation rectifies autism-associated endothelial dysfunction
Ouellette, J.; Warsi, S.; Romero, P.; Khare, P.; Naz, S.; Aubert-Tandon, L.; Pileggi, C.; Yandiev, S.; Freitas-Andrade, M.; Comin, C. H.; Harper, M.-E.; Manickam, D. S.; Dabertrand, F.; Saghatelyan, A.; Lacoste, B.
10.1101/2025.06.02.657522 — cell biology — Posted on 2025-06-03
2271 Aberrant cerebrovascular reactivity presents as an early biomarker of psychosis susceptibility in patients with 22q11.2DS
Delavari, F.; Moia, S.; Forrer, S.; Sandini, C.; Kojovic, N.; Pascucci, A.; Lacour, C.; Eliez, S.; Van De Ville, D.
10.1101/2025.06.02.657392 — neuroscience — Posted on 2025-06-03
2272 Autism-associated SCN2A deficiency disrupts cortico-striatal circuitry in human brain assembloids
Chen, X.; Zhang, J.; Wu, J.; Robinson, M. J.; Kothandaraman, H.; Yoo, Y.-E.; Dopeso-Reyes, I. M. G.; Buffenoir, T. D.; Halurkar, M. S.; Zhang, Z.; Wang, M.; Creager, E. N.; Zhao, Y.; Olivero-Acosta, M. I.; Wettschurack, K. W.; Que, Z.; Yuan, C.; Schaser, A. J.; Lanman, N. A.; Rochet, J.-C.; Skarnes, W. C.; Kremer, E. J.; Yang, Y.
10.1101/2025.06.02.657036 — neuroscience — Posted on 2025-06-03
2275 Multimodal Validation of the Existence of Transitional Cerebellar Progenitors in the Human Fetal Cerebellum
Luo, Z.; Xia, M.; Zhang, F.; Xin, D.; Rao, R.; Kiang, K.; Berry, K.; Xiong, Y.; Liu, H.; Lin, Y.; Hu, M.; Xin, M.; Ma, J.; Li, H.; Taylor, M. D.; Zhou, W.; Lu, Q. R.
10.1101/2025.06.01.657310 — developmental biology — Posted on 2025-06-03
2276 An applicable and efficient retrograde monosynaptic circuit mapping tool for larval zebrafish
Chen, T.; Deng, Q.; Lin, K.; Zheng, X.; Wang, X.; Zhong, Y.; Ning, X.; Li, Y.; Xu, F.; Du, J.; Du, X.
10.1101/2024.06.27.601104 — neuroscience — Posted on 2025-06-02
2278 Evaluation of a prototype Orbitrap Astral Zoom mass spectrometer for quantitative proteomics - Beyond identification lists
Hsu, C.; Shulman, N.; Stewart, H.; Petzoldt, J.; Pashkova, A.; Plubell, D.; Denisov, E.; Hagedorn, B.; Damoc, E.; MacLean, B. X.; Remes, P. M.; Canterbury, J. D.; Makarov, A.; Hock, C.; Zabrouskov, V.; Wu, C. C.; MacCoss, M. J.
10.1101/2025.05.30.657132 — biochemistry — Posted on 2025-06-02
2281 Alpha and Beta Oscillations Mediate the Effect of Motivation on Neural Coding of Cognitive Flexibility
Delgado, J. M. C.; Ison, M. J.; Muhle-Karbe, P. S.; Stokes, M. G.; Hall-McMaster, S.; Myers, N. E.
10.1101/2025.03.11.642697 — neuroscience — Posted on 2025-06-02
2282 In vivo deep-brain microscopy at submicrometer resolution with refractive index-matched prism interfaces
Takahashi, T.; Zhou, Y.; Tsutsumi, M.; Ito, C.; Hatakeyama, A.; Ishii, H.; Saitoh, A.; Yukawa, H.; Nabekura, J.; Nemoto, T.; Otomo, K.; Matsuhisa, N.; Agetsuma, M.
10.1101/2025.05.30.657010 — neuroscience — Posted on 2025-06-02
2283 Quantum Cognition Machine Learning for Forecasting Chromosomal Instability
Di Caro, G.; Kirakosyan, V.; Abanov, A. G.; Candelori, L.; Hartmann, N.; Lam, E. T.; Musaelian, K.; Samson, R.; Villani, D.; Wells, M. T.; Wenstrup, R. J.; Xu, M.
10.1101/2025.05.30.656882 — cancer biology — Posted on 2025-06-02
2284 Biomni: A General-Purpose Biomedical AI Agent
Huang, K.; Zhang, S.; Wang, H.; Qu, Y.; Lu, Y.; Roohani, Y.; Li, R.; Qiu, L.; Zhang, J.; Di, Y.; Marwaha, S.; Carter, J.; Zhou, X.; Wheeler, M. T.; Bernstein, J.; Wang, M.; He, P.; Zhou, J.; Snyder, M.; Cong, L.; Regev, A.; Leskovec, J.
10.1101/2025.05.30.656746 — bioinformatics — Posted on 2025-06-02
2290 Venus-MAXWELL: Efficient Learning of Protein-Mutation Stability Landscapes using Protein Language Models
Yu, Y.; Jiang, F.; Ma, X.; Zhang, L.; Zhong, B.; Ouyang, W.; Fan, G.; Yu, H.; Hong, L.; Li, M.
10.1101/2025.05.30.656964 — bioinformatics — Posted on 2025-06-02
2293 Sex specific correction of maternal inflammation-induced behavioral abnormalities by the inhibition of colony-stimulating factor 1 receptor
Delpech, J. C.; Yeh, H.; Kalavai, S. V.; You, Y.; Ruan, Z.; Touch, N.; Hersh, S.; Monguillon, P.; Johnson, W. E.; Rau, A.; Madore-Delpech, C.; Ikezu, T.; Ikezu, S.
10.1101/2025.05.30.657085 — animal behavior and cognition — Posted on 2025-06-02
2297 Must epidemiologically impactful vector control interventions disrupt mosquito population structure? A case study of a cluster-randomised controlled trial.
Dennis, T. P. W.; Guelbeogo, W. M.; Ferguson, H. M.; Lindsay, S.; N'Fale, S.; Pignatell, P.; Ranson, H.; Sanou, A.; Tiono, A.; Weetman, D.; Viana, M.
10.1101/2025.04.16.649034 — ecology — Posted on 2025-06-02
2298 piRNAs are abundant in the early embryo of the crustacean Parhyale hawaiensis
Calvo Gonzalez, L.; Pettini, T.; Ylla, G.; Ronshaugen, M. R.; Griffiths-Jones, S.
10.1101/2025.05.30.656998 — developmental biology — Posted on 2025-06-02
2299 Engineering a mouse-adapted SADS-CoV and establishing a neonatal mouse model to study its infection
Zhang, H.; Zhou, J.; Li, P.; Zhang, M.; Jing, R.; Zhu, H.; Lang, Y.; He, Q.; Zhang, M.; Li, W.
10.1101/2025.06.02.657353 — microbiology — Posted on 2025-06-02
2300 Genome-wide CRISPR/Cas9 knockout screen identifies host factors essential for Bovine Parainfluenza Virus Type 3 replication
Hao, J.; Gao, X.; Light, C.; Sun, Y.; Lu, S.; Tian, Y.; Gao, X.; Su, Y.; Gao, J.; Huang, X.; Wang, J.; Zhang, Q.; Hai, R.; Hu, W.; Wang, G.
10.1101/2025.06.02.657355 — microbiology — Posted on 2025-06-02
2301 HLA-DQ monomer-based enrichment of alloreactive CD4 T cells
Zhanzak, Z.; Cina, D.; Zhang, X.; Hadley, A.; Kissick, H.; Larsen, C.
10.1101/2025.05.30.656890 — immunology — Posted on 2025-06-02
2302 Multi-Stable Bimodal Perceptual Coding within the Ventral Premotor Cortex
Andrade-Ortega, B.; Diaz, H.; Bayones, L.; Alvarez, M.; Zainos, A.; Rivera-Yoshida, N.; Franci, A.; Romo, R.; Rossi-Pool, R.
10.1101/2024.12.11.628069 — neuroscience — Posted on 2025-06-02
2304 Single-cell transcriptomics uncovers that cell-to-cell communication controls p53 activation
Castellano, L.; Robinson, M. E.; Dabrowska, A.; Feldhahn, N.; Ottaviani, S.; Stebbing, J.
10.1101/2025.05.30.657016 — cancer biology — Posted on 2025-06-02
2307 The effect of aging on post-translational modifications of wild-type human SOD1 and the A5V ALS mutant
de Souza, G. F.; Magalhaes, R. S. S.; Neto, J. R. M.; Martins, M.; Follmer, C.; Junqueira, M.; Eleutherio, E. C. A.
10.1101/2025.06.02.657411 — biochemistry — Posted on 2025-06-02
2308 Spatial metabolic gradients in the liver and small intestine
Samarah, L. Z.; Zheng, C.; Xing, X.; Lee, W. D.; Afriat, A.; Chitra, U.; MacArthur, M.; Lu, W.; Jankowski, C. S. R.; Ma, C.; Hunter, C. J.; Raphael, B. J.; Rabinowitz, J. D.
10.1101/2025.06.02.657306 — biochemistry — Posted on 2025-06-02
2310 Time Series GWAS for Iron Deficiency Chlorosis Tolerance in Soybean using Aerial Imagery
Carroll, M. E.; Rairdin, A. M.; Van der Laan, L.; Ferela, A.; Hanumolu, S.; Sarkar, S.; Ganapathysubramanian, B.; Singh, A.; Singh, A. K.
10.1101/2025.05.30.657051 — genetics — Posted on 2025-06-02
2313 Protists Exhibit Stronger and More Recent Oceanic Genetic Structure than Archaeplastida and Metazoa
Gonzalez-Miguens, R.; Galvez-Morante, A.; Torruella, G.; Berney, C.; Casacuberta, E.; Ruiz-Trillo, I.
10.1101/2025.06.02.657477 — microbiology — Posted on 2025-06-02
2314 Human Cytomegalovirus UL78 is a Nuclear-Localized GPCR Necessary for Efficient Reactivation from Latent Infection in CD34+ Hematopoietic Progenitor Cells
Medica, S.; Diggins, N. L.; Denton, M.; Turner, R. L.; Pung, L. J.; Mayo, A. T.; Mitchell, J.; Slind, L.; Nguyen, L. K.; Beechwood, T. A.; Sulgey, G.; Kreklywich, C. N.; Malouli, D.; Caposio, P.; Streblow, D. N.; Hancock, M. H.
10.1101/2025.06.02.657350 — microbiology — Posted on 2025-06-02
2315 Phylogeny-aware comparative genomics of Vibrio vulnificus links genetic traits to pathogenicity
Delgado, L. F.; Riedinger, D. J.; Fernandez-Juarez, V.; Herlemann, D. P. R.; Pansch, C.; Katarzyte, M.; Gyraite, G.; Reusch, T. B. H.; Rakowski, M.; Piwosz, K.; Wozniczka, A.; Benterbusch-Brockmöller, H.; Sperlea, T.; Dupke, S.; Scholz, H. C.; Kube, S.; Riemann, L.; Labrenz, M.; Andersson, A.
10.1101/2025.06.02.657354 — microbiology — Posted on 2025-06-02
2317 Episymbiotic Saccharibacteria suppresses epithelial immunoactivation through Type IV pili and TLR2 dependent endocytosis
Chouhan, D.; Grossman, A. S.; Kerns, K. A.; Stocke, K. S.; Kim, M.; Dong, P.-T.; Kumar, A.; Lei, L.; Lamont, R. J.; McLean, J. S.; He, X.; Bor, B.
10.1101/2025.05.30.656655 — immunology — Posted on 2025-06-02
2319 From Belief to Brain: How Growth Mindset Optimizes Cortico-Striatal Dynamics for Cognitive Development
Zhao, Y.; Cui, J.; Zhang, Z.; Zhao, H.; Xu, J.; Chen, M.; Hao, L.; He, Y.; Wang, H.; Wang, Y.; Wang, D.; Hu, Y.; Han, Z. R.; Tan, S.; Men, W.; Gao, J.; Chen, L.; He, Y.; Tao, S.; Dong, Q.; Qin, S.
10.1101/2022.07.11.499525 — neuroscience — Posted on 2025-06-02
2322 LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics
Tombesi, G.; Kompella, S.; Favetta, G.; Chen, C.; Ornaghi, M.; Zhao, Y.; Morosin, E.; Sevegnani, M.; Lama, A.; Marte, A.; Battisti, I.; Iannotta, L.; Plotegher, N.; Civiero, L.; Onofri, F.; Eickholt, B. J.; Piccoli, G.; Arrigoni, G.; Beccano-Kelly, D.; Manzoni, C.; Parisiadou, L.; Greggio, E.
10.1101/2022.10.31.514622 — neuroscience — Posted on 2025-06-02
2327 Computational design of conformation-biasing mutations to alter protein functions
Cavanagh, P. E.; Xue, A. G.; Dai, S.; Qiang, A.; Matsui, T.; Ting, A. Y.
10.1101/2025.05.03.652001 — biophysics — Posted on 2025-06-02
2328 Quantitative isoform profiling using deep coverage long-read RNA sequencing across early endothelial differentiation
Wissel, D.; Mehlferber, M. M.; Nguyen, K. M.; Pavelko, V.; Tseng, E.; Robinson, M. D.; Sheynkman, G. M.
10.1101/2025.05.30.656561 — bioinformatics — Posted on 2025-06-02
2329 Biocompatible Multi-functional Polymeric Material for Mineralized Tissue Adhesion
Luo, Y.; Zhang, C.; Fulco, S.; Liu, J.; Chen, K.; Hu, Y.; Jiang, Y.; Xu, R.; Rakesh, L.; Ozer, F.; Tertuliano, O.; Turner, K.; Vining, K. H.
10.1101/2025.05.30.656989 — bioengineering — Posted on 2025-06-02
2330 Enabling Plasmid-based Expression in Clostridium kluyveri using a Biparental Methylation-Conjugation System
Agena, E. M.; Badani, A. A.; Linder, B. G.; Gois, I. M.; Dempster, A. W.; Minton, N. P.; Mahadevan, R.; Lawson, C. E.
10.1101/2025.05.30.657078 — bioengineering — Posted on 2025-06-02
2335 Differential metaproteomics of bacteria grown in vitro and in planta reveals functions used during growth on maize roots
Garrell, A.-K.; Cheadle, J.; Crook, N.; Pal, G.; Septer, A. N.; Wagner, M. R.; Beck, A. E.; Kleiner, M.
10.1101/2025.06.02.657423 — microbiology — Posted on 2025-06-02
2339 GENOTYPIC DETECTION OF ANTIBIOTIC-RESISTANT GENES IN EMERGING BACTERIAL PATHOGENS FROM NEONATAL SEPSIS PATIENTS IN LAGOS
Adegboyega, H. O.; Banjo, T. A.; Deji-Agboola, A. M.; Iwalokun, B.; Mutiu, W. B.; Osinupebi, O. A.; Shorunmu, T. O.; Oladoja, F. A.; Fatungase, O. M.; Adeyanju, M. M.; Akindele, R. A.; Fakunle, P. B.; Olabode, B. A.; Ajayi, O. O.; Onadeko, O.; Oyelekan, A. A. A.; Oritogun, K. S.; Ariyibi, S. O.; Omirin, E. S.
10.1101/2025.06.02.657359 — microbiology — Posted on 2025-06-02
2343 Differential Decay of Multiple eNA Components from a Cetacean
Brandao-Dias, P. F.; Shaffer, M.; Guri, G.; Parsons, K. M.; Kelly, R. P.; Allan, E. A.
10.1101/2025.05.09.653189 — molecular biology — Posted on 2025-06-02
2344 Antibiotic potentiation and inhibition of cross-resistance in pathogens associated with cystic fibrosis
Kaderabkova, N.; Furniss, R. C. D.; Maslova, E.; Potter, K. E.; Eisaiankhongi, L.; Bernal, P.; Filloux, A.; Landeta, C.; Gonzalez, D.; McCarthy, R. R.; Mavridou, D.
10.1101/2023.08.02.551661 — microbiology — Posted on 2025-06-02
2345 Mapping early patterning events in human neural development usingan in-vitro microfluidic stem cell model
Rathore, G. S.; Ankjaer, M.; Rifes, P.; Hanninen, E.; Calleja, F. S.; Rusimbi, C.; Kajtez, J.; Nygaard, A. H.; Piilgaard, L. S.; Dubonyte, U.; Norgaard, Z. A.; Christensen, J. B.; Egerod, K. L.; Camp, J. G.; Pers, T.; Treutlein, B.; Kirkeby, A.
10.1101/2025.05.23.655442 — neuroscience — Posted on 2025-06-02
2346 Human gut commensal Alistipes timonensis modulates the host lipidome and delivers anti-inflammatory outer membrane vesicles to suppress colitis in an Il10-deficient mouse model
Older, E. A.; Mitchell, M. K.; Campbell, A.; Lian, X.; Madden, M.; Wang, Y.; van de Wal, L. E.; Zaw, T.; VanderVeen, B. N.; Tatum, R.; Murphy, E. A.; Chen, Y.-H.; Fan, D.; Ellermann, M.; Li, J.
10.1101/2024.10.23.619966 — biochemistry — Posted on 2025-06-02
2350 AcrIF11 is a potent CRISPR-specific ADP-ribosyltransferase encoded by phage and plasmid
Chen, D. F.; Roe, L. T.; Li, Y.; Borges, A. L.; Zhang, J. Y.; Babbar, P.; Maji, S.; Stevens, M. G. V.; Correy, G. J.; Diolaiti, M. E.; Smith, D. H.; Ashworth, A.; Stroud, R. M.; Kelly, M. J. S.; Bondy-Denomy, J.; Fraser, J. S.
10.1101/2024.08.26.609590 — microbiology — Posted on 2025-06-02
2351 Intrinsic dynamic shapes responses to external stimulation in the human brain
Nentwich, M.; Leszczynski, M.; Schroeder, C. E.; Bickel, S.; Parra, L. C.
10.1101/2024.08.05.606665 — neuroscience — Posted on 2025-06-02
2353 Automated Classification of Sleep-Wake States and Seizures in Mice
Harvey, B. J.; Olah, V. J.; Aiani, L. M.; Rosenberg, L. I.; Lasky, D. J.; Moxon, B.; Pedersen, N. P.
10.1101/2023.04.07.536063 — neuroscience — Posted on 2025-06-02
2355 Microtubule forces drive nuclear damage in LMNA cardiomyopathy
Amiad Pavlov, D.; Heffler, J.; Corredera, C. S.; Dehghany, M.; Shen, K. M.; Zuela-Sopilniak, N.; Randell, R.; Uchida, K.; Jain, R.; Shenoy, V.; Lammerding, J.; Prosser, B. L.
10.1101/2024.02.10.579774 — cell biology — Posted on 2025-06-02
2357 Whole-brain meso-vein imaging in living humans using fast 7 T MRI
Gulban, O. F.; Stirnberg, R.; Tse, D. H. Y.; Pizzuti, A.; Koiso, K.; Archila-Melendez, M. E.; Huber, R.; Bollmann, S.; Goebel, R.; Kay, K.; Ivanov, D.
10.1101/2025.03.23.644588 — neuroscience — Posted on 2025-06-02
2358 Evolution of object identity information in sensorimotor cortex throughout grasp
Yan, Y.; Sobinov, A. R.; Goodman, J. M.; Okorokova, E. V.; Miller, L. E.; Bensmaia, S. J.
10.1101/2024.10.11.617909 — neuroscience — Posted on 2025-06-02
2360 Persistent dopamine-dependent remodeling of the neural transcriptome in response to pregnancy and postpartum
Chan, J. C.; Di Salvo, G.; Cunningham, A. M.; Dutta, S.; Brindley, E. A.; Weekley, B. H.; Wan, E.; Zhang, C.; Mechawar, N.; Turecki, G.; Maze, I.
10.1101/2025.02.20.639313 — neuroscience — Posted on 2025-06-02
2362 FEDRANN: effective overlap graph construction based on dimensionality reduction and approximate nearest neighbors
Zhang, J.-Y.; Miao, C.; Qiu, T.; Xia, X.; He, L.; He, J.; Sun, Y.; Zeng, T.; Li, Y.; Xu, X.; Ruan, Y.; Dong, Y.
10.1101/2025.05.30.656979 — bioinformatics — Posted on 2025-06-02
2364 MARLOWE: Taxonomic Characterization of Unknown Samples for Forensics Using De Novo Peptide Identification
Jenson, S. C.; Chu, F.; Alves, G.; Ogurtsov, A. Y.; Barente, A. S.; Crockett, D. L.; Lamar, N. C.; Merkley, E. D.; Yu, Y.-K.; Jarman, K. H.
10.1101/2024.09.30.615220 — bioinformatics — Posted on 2025-06-02
2368 Persistent Decision-Making in Mice, Monkeys, and Humans
Laurie, V.-J.; Shourkeshti, A.; Chen, C. S.; Herman, A. B.; Grissom, N. M.; Ebitz, R. B.
10.1101/2024.05.07.592970 — animal behavior and cognition — Posted on 2025-06-02
2370 A haplotype-resolved view of human gene regulation
Vollger, M. R.; Swanson, E. G.; Neph, S. J.; Ranchalis, J.; Munson, K. M.; Ho, C.-H.; Cheng, Y. H. H.; Sedeno-Cortes, A. E.; Fondrie, W. E.; Bohaczuk, S. C.; Dippel, M. A.; Mao, Y.; Parmalee, N. L.; Mallory, B. J.; Harvey, W. T.; Kwon, Y.; Garcia, G. H.; Hoekzema, K.; Meyer, J. G.; Cicek, M.; Eichler, E. E.; Noble, W. S.; Witten, D. M.; Bennett, J. T.; Ray, J. P.; Stergachis, A. B.
10.1101/2024.06.14.599122 — genomics — Posted on 2025-06-02
2371 Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity
Sayeed, K.; Parameswaran, S.; Beucler, M. J.; Edsall, L. E.; VonHandorf, A.; Crowther, A.; Donmez, O. A.; Hass, M. R.; Richards, S.; Forney, C. R.; Hesse, H. K.; Jones, S. H.; Dunn, K. A.; Wright, J.; Leong, M. M.; Murray-Nerger, L. A.; Yechoor, V. K.; Gewurz, B. E.; Kaufman, K. M.; Harley, J. B.; Zhao, B.; Miller, W. E.; Kottyan, L. C.; Weirauch, M. T.
10.1101/2024.04.12.588762 — genomics — Posted on 2025-06-02
2372 A curated dataset and web application for Integrative Analysis of Ancient DNA from Britain and Ireland
Metz, S.; Fischer, C.-E.; Bleasdale, M.; Castells Navarro, L.; Buster, L.; Legge, M.; Reich, D.; Armit, I.
10.1101/2025.05.30.657009 — genetics — Posted on 2025-06-02
2380 Synthetic Serum Markers Enable Noninvasive Monitoring of Gene Expression in Primate Brains
Lee, S.; Romac, M.; Watanabe, S.; Chernov, M.; Li, H.; Raisley, E.; Szablowski, J. O.; Costa, V. D.
10.1101/2025.06.01.657212 — neuroscience — Posted on 2025-06-02
2382 C9orf72 polyGA knock-in mice exhibit mild motor and proteomic changes consistent with ALS/FTD
Milioto, C.; Carcole, M.; Zanovello, M.; Ahmed, M.; Nirujogi, R. S.; Biggs, D.; Katona, E.; Glaria, I.; Santos, A.; Devoy, A.; Fratta, P.; Alessi, D. R.; Davies, B.; Greensmith, L.; Fisher, E.; Isaacs, A. M.
10.1101/2025.05.30.656994 — neuroscience — Posted on 2025-06-02
2385 Phenotypic and transcriptomic characterization of bicalutamide and enzalutamide resistance in castration-resistant prostate cancer cells
Natkin, R.; Paloneva, M. I.; Raittinen, P. V.; Syvala, H.; Blauer, M.; Tammela, T. L.; Ilmonen, P.; Nykter, M.; Siltari, A.; Murtola, T. J.
10.1101/2025.05.30.656961 — cancer biology — Posted on 2025-06-02
2390 Visual working memory precision is under voluntary control
Sahakian, A.; Koevoet, D.; Paffen, C. L. E.; Gayet, S.; Van der Stigchel, S.
10.1101/2025.05.29.656854 — neuroscience — Posted on 2025-06-02
2391 Spine-Prints: Transposing Brain Fingerprints to the Spinal Cord
Ricchi, I.; Santoro, A.; Kinany, N.; Landelle, C.; Khatibi, A.; Vahdat, S.; Doyon, J.; Barry, R. L.; Van De Ville, D.
10.1101/2025.05.30.656545 — neuroscience — Posted on 2025-06-02
2394 Gestational Chronic Intermittent Hypoxia Triggers Maternal Inflammation and Disrupts Placental Stress Responses
Gardner, J. J.; Oliveira da Silva, R. d. N.; Bradshaw, J. L.; Mabry, S.; Wilson, E. N.; Hula, N.; Tucker, S. M.; Gorham, I. K.; Escalera, D.; Lopez, L.; Phillips, N. R.; Cunningham, R. L.; Goulopoulou, S.
10.1101/2025.05.29.656944 — physiology — Posted on 2025-06-02
2395 CASP16 protein monomer structure prediction assessment
Yuan, R.; Zhang, J.; Kryshtafovych, A.; Schaeffer, R. D.; Zhou, J.; Cong, Q.; Grishin, N. V.
10.1101/2025.05.29.656942 — biophysics — Posted on 2025-06-02
2404 A cell atlas of the developing human outflow tract of the heart and its adult derivatives
Leshem, R.; Murtuza Baker, S.; Mallen, J.; Wang, L.; Dark, J.; Rattray, M.; Sharrocks, A.; Piper Hanley, K.; Hanley, N.; Bamforth, S.; Bobola, N.
10.1101/2023.04.05.535627 — developmental biology — Posted on 2025-06-02
2405 Conserved and Unique Features of Terminal Telomeric Sequences in ALT-Positive Cancer Cells
Azeroglu, B.; Wu, W.; Pavani, R.; Sandhu, R.; Matsumoto, T.; Nussenzweig, A.; Lazzerini Denchi, E.
10.1101/2025.02.27.640565 — molecular biology — Posted on 2025-06-02
2407 Synthetic Serum Markers Enable Noninvasive Monitoring of Gene Expression in Primate Brains
Lee, S.; Romac, M.; Romac, M. D.; Chernov, M.; Li, H.; Raisley, E.; Szablowski, J. O.; Costa, V. D.
10.1101/2025.06.01.657212 — neuroscience — Posted on 2025-06-02
2410 Informed Data-Independent Acquisition Enables Targeted Quantification of Key Regulatory Proteins in Cell Fate Decision at Single-Cell Resolution
Woessmann, J.; Petrosius, V.; Schovsbo, S.; Arrey, T. N.; Furtwaengler, B.; Op de Beeck, J.; Damoc, E.; Porse, B. T.; Schoof, E. M.
10.1101/2025.05.30.656945 — systems biology — Posted on 2025-06-02
2411 Active learnings impact on student course performance in STEM varies by type and intensity
Xu, S.; Velasco, V.; Hill, M. J.; Tran, E.; Agrawal, S.; Arroyo, E. N.; Behling, S.; Chambwe, N.; Cintron, D. L.; Cooper, J. D.; Dunster, G.; Grummer, J. A.; Hennessey, K.; Hsiao, J.; Iranon, N.; Jones, L.; Jordt, H.; Keller, M.; Lacey, M. E.; Littlefield, C. E.; Lowe, A.; Newman, S.; Okolo, V.; Olroyd, S.; Peecook, B. R.; Pickett, S. B.; Slager, D. L.; Caviedes-Solis, I. W.; Stanchak, K. E.; Sundaravaradan, V.; Valdebenito, C.; Williams, C. R.; Zinsli, K. A.; Freeman, S.; Theobald, E. J.
10.1101/2025.06.01.657285 — scientific communication and education — Posted on 2025-06-02
2412 Prediction of harvest-related traits in barley using high-throughput phenotyping data and machine learning
Tietze, H.; Abdelhakim, L.; Pleskacova, B.; Kurtz-Sohn, A.; Fridman, E.; Nikoloski, Z.; Panzarova, K.
10.1101/2025.05.29.656856 — plant biology — Posted on 2025-06-02
2414 Perinatal Asphyxia Alters Physiological Responses and Ex Vivo Cardiovascular Function of Preterm Growth-Restricted Lambs
Azman, Z.; Piscopo, B. R.; Sutherland, A. E.; Thiel, A.; Zahra, V.; Pham, Y.; Nitsos, I.; Hossain, M. M.; Malhotra, A.; Miller, S. L.; Bubb, K. J.; Polglase, G. R.; Allison, B. J.
10.1101/2025.05.27.656490 — physiology — Posted on 2025-06-02
2415 Regulation of Aldosterone Secretion by Substance P and the NK1 Receptor in Aldosterone-Producing Adenomas
Lopez, A.-G.; Duparc, C.; Renouf, S.; D'Agostino, M.; De Sousa, K.; Amar, L.; Defortescu, G.; Manceau, G.; Sabourin, J.-C.; Fernandes-Rosa, F. L.; Zennaro, M.-C.; Meatchi, T.; Nicolas, G.; Louiset, E.; Lefebvre, H.
10.1101/2025.05.28.656733 — physiology — Posted on 2025-06-02
2422 Structure of a novel contractile injection system in Salmonella enterica subsp. salamae
Ejaz, R. N.; Funke, K.; Kielkopf, C. S.; Martin, F. J. O.; Siborova, M.; Hendriks, I. A.; Sofos, N. H.; Pape, T. H.; Steiner-Rebrova, E. M.; Nielsen, M. L.; Erhardt, M.; Taylor, N. M. I.
10.1101/2025.06.01.657177 — microbiology — Posted on 2025-06-02
2425 From Morphology to Computation: How Synaptic Organization Shapes Place Fields in CA1 Pyramidal Neurons
Tasciotti, S.; Iascone, D. M.; Chavlis, S.; Hammond, L.; Katz, Y.; Losonczy, A.; Polleaux, F.; Poirazi, P.
10.1101/2025.05.30.657022 — neuroscience — Posted on 2025-06-02
2426 Large Language Models Reveal the Neural Tracking of Linguistic Context in Attended and Unattended Multi-Talker Speech
Puffay, C.; Mischler, G.; Choudhari, V.; Vanthornhout, J.; Bickel, S.; Mehta, A. D.; Schevon, C. A.; McKhann, G. M.; Van hamme, H.; Francart, T.; Mesgarani, N.
10.1101/2025.04.24.648897 — neuroscience — Posted on 2025-06-02
2428 NEUROGLIAL CB1 RECEPTORS CONTROL NAVIGATION STRATEGIES
Egana-Huguet, J.; Sangroniz-Beltran, L.; Baraibar, A. M.; Reyes-Velasquez, P.; Landgraf, N.; Torres-Maldonado, P.; Rodriguez-Cedres, C.; Julio-Kalajzic, F.; Piriz, J.; Ramos-Uriarte, A.; Grandes, P.; Marsicano, G.; Mato, S.; Ceprian, M.; Soria-Gomez, E.
10.1101/2025.05.27.656352 — neuroscience — Posted on 2025-06-02
2429 Separate timescales for spatial and anatomical information processing of body stimuli
Waltzing, B. M.; McAteer, S.; Moreno-Verdu, M.; Van Caenegem, E. E.; Du, Y.; Hardwick, R. M.
10.1101/2024.10.07.616993 — neuroscience — Posted on 2025-06-02
2430 An in vitro human vessel to study Neisseria meningitidis colonization and vascular damages
Pinon, L.; Chabaud, M.; Nivoit, P.; Wong-Ng, J.; Nguyen, T.-T.; Paul, V.; Bouquerel, C.; Goussard, S.; Smilovici, P.; Frachon, E.; Obino, D.; Gobaa, S.; Dumenil, G.
10.1101/2024.02.09.579276 — synthetic biology — Posted on 2025-06-02
2432 IRE1 activity regulates tumour and microenvironment cell lineage states while stratifying localised and metastatic prostate cancer.
Doultsinos, D.; Tomljanovic, I.; Pilalis, E.; Abusamra, S.; Parmentier, R.; Bridges, I. E.; Figiel, S.; Zekri, Y.; Hester, J.; Leach, D.; Bevan, C. L.; Lamb, A. D.; Zwart, W.; Chatziioannou, A.; Le Magnen, C.; Mills, I. G.
10.1101/2025.03.13.643042 — cancer biology — Posted on 2025-06-02
2436 Genomic and Phenotypic Characterization of Mupirocin Resistant Staphylococcus aureus Clinical Isolates
Virgillio, A. M.; Felton, E. A.; Jackson, J. K.; Kennedy, S. J.; Becker, D. N.; Lima, A.; Atrubin, K.; Cella, E.; Azarian, T.; Silbert, S.; Shaw, L. N.; Kim, K.
10.1101/2025.04.16.648996 — microbiology — Posted on 2025-06-02
2438 Chorionic Gonadotropin Beta 7 is a marker of immune evasion in cancer
McKellar, S. A.; Pineda, J. M. B.; Lattupally, R.; Codd, A. S.; Newell, E.; Lu, S. X.; Bradley, R. K.
10.1101/2025.05.28.656535 — cancer biology — Posted on 2025-06-02
2440 A NEW DYSTROPHIN DEFICIENT RAT MODEL MIRRORING EXON SKIPPING IN PATIENTS WITH DMD EXON 45 DELETIONS
JABER, A.; WANG, T.; DAOUD, C.; ALBINI, S.; CORRE, G.; BELLEC, J.; BOVOLENTA, M.; DORVAL, A.; DUBOIS, A.; PHILIDET, L.; WARTHI, G.; RICHARD, I.
10.1101/2025.05.30.656540 — genetics — Posted on 2025-06-02
2441 Viral adsorption to Moore swabs in passive wastewater sampling
Rao, G.; Purvis, T.; Cha, G.; Dalton, J.; Fisher, M.; Graham, K. E.; Konstantinidis, K. T.; Linden, Y.; Bivins, A.; Brinton, M. A.; Stauber, C.; Brown, J.
10.1101/2025.05.30.656954 — microbiology — Posted on 2025-06-02
2442 Lack of functional STING modulates immunity but does not protect dopaminergic neurons in the alpha-synuclein preformed fibrils Parkinson's Disease mouse model
Klaestrup, I. H.; Reinert, L. S.; Ferreira, S. A.; Lauritsen, J.; Toft, G. U.; Gram, H.; Jensen, P. H.; Paludan, S. R.; Romero-Ramos, M.
10.1101/2025.05.30.656977 — neuroscience — Posted on 2025-06-02
2443 Slow-Timescale Regulation of Dopamine Release and Mating Drive over Days
Sunkavalli, P. S.; Madara, J. C.; Christenson, L. F.; Diaz, A.; Chen, J.; Ravotto, L.; Patriarchi, T.; Andermann, M. L.; Zhang, S. X.
10.1101/2025.05.29.656898 — neuroscience — Posted on 2025-06-02
2444 Shared and distinct microRNA profiles between HT22, N2A and SH-SY5Y cell lines and primary mouse hippocampal neurons
Jimenez Mateos, E. M.; Murphy, R.; Villegas-Salmeron, J.; Sanz-Rodriguez, A.; Engel, T.; Mooney, C.; Henshall, D. C.
10.1101/2025.06.01.657291 — neuroscience — Posted on 2025-06-02
2445 Genotype-Specific Electroretinogram Signatures in Drosophila: Implications for Neurodegeneration Models Using w1118 Backgrounds
Manuel, N.; Mallipudi, M.; Gajwani, A.; Gopalkrishna Shetty Sreenivasa Murthy, S.; Jupiter, D. C.; Krishnan, B.
10.1101/2024.11.29.626125 — neuroscience — Posted on 2025-06-02
2446 Adverse prognosis of GM-CSF expression in human cutaneous melanoma
Garcia-Martinez, E.; Nieto-Valle, A.; Barrio-Alonso, C.; Lopez-Navarro, B.; Aviles-Izquierdo, J. A.; Parra-Blanco, V.; Gutierrez-Seijo, A.; Sanchez-Mateos, P.; Samaniego Garcia, R.
10.1101/2025.05.30.656980 — cancer biology — Posted on 2025-06-02
2447 Soil to human health continuum: Exploring ergothioneine and mycorrhizal fungi in shaping the wheat microbiome
Ravi, S. S. N.; Pipinos, A.; Insley, N.; Kan, J.; Zinati, G.; Smith, A.; Heller, W.; Bais, H.
10.1101/2025.05.28.656623 — plant biology — Posted on 2025-06-02
2448 Effect of Chronic Stress on Whole Blood Transcriptome: A Meta-Analysis of Publicly Available Datasets from Rodent Models
Flandreau, E. I.; Nguyen, D. M.; Hagenauer, M. H.; Nguyen, M.; Kim, H.; Duan, T.; Bader, A.; Watson, S.; Akil, H.
10.1101/2025.05.30.657043 — genomics — Posted on 2025-06-01
2449 Non-canonical enhancers control gene expression and cell fate in human pluripotent stem cells
Cao, Y.; Dovgusha, O.; Ebrahimi, A.; Bevan, S.; Widmer, L.; Torabi, F.; Kurlovich, J.; Rodriguez-Polo, I.; Khan, S.; Patel, M.; Pradeepa, M. M.; Guenesdogan, U.; Schoenfelder, S.
10.1101/2025.06.01.657118 — genomics — Posted on 2025-06-01
2455 Nucleus accumbens neuron subtype translatome signatures in socially stress females
Kumar, G.; Franco, D.; Basu, M.; Olusakin, J.; Campbell, R.; Ament, S. A.; Fox, M.; Lobo, M. K.
10.1101/2025.06.01.656319 — neuroscience — Posted on 2025-06-01
2456 Uncovering the invisible giant: Amyloid β plaques and their proposed association with waste removal in Alzheimer-affected human hippocampus
Fabian-Fine, R.; Roman, A. G.; Winters, M. J.; Lathram, K. J.; Bennett, C. H.; Kipingi, L. K.; Paul, C. M.; Altman, L. M.; Carrillo, I. C.; Joyce, F. M.; Kragh, L. A.; McKnight, T. J.; Reding, C. J.; Reiderer, L. J.; Rivera, L. J.; Steen, H. A.; Weaver, A. L.
10.1101/2025.06.01.657219 — neuroscience — Posted on 2025-06-01
2458 Astrocyte regional specialization is shaped by postnatal development
Schroeder, M. E.; McCormack, D. M.; Metzner, L.; Kang, J.; Li, K. X.; Yu, E.; Melamed, L.; Levandowski, K. M.; Zaniewski, H.; Zhang, Q.; Boyden, E.; Krienen, F. M.; Feng, G.
10.1101/2024.10.11.617802 — neuroscience — Posted on 2025-06-01
2459 Correlative light and electron microscopy reveals the fine circuit structure underlying evidence accumulation in larval zebrafish
Boulanger-Weill, J.; Kaempf, F.; Schuhknecht, G. F. P.; Schalek, R. L.; Petkova, M.; Vohra, S. K.; Wu, Y.; Savaliya, J. H.; Tiller, R.; Herrera, K. J.; Naumann, H.; Eberle, M.; Rencken, S.; Stingl, M.; Hebling, A.; Hockling, D.; Slangewal, K.; Deng, Z.; Wang, R. C.; Zhang, L. L.; Kirchberger, K. N.; Bianco, I. H.; Baum, D.; Bene, F. D.; Engert, F.; Lichtman, J. W.; Bahl, A.
10.1101/2025.03.14.643363 — neuroscience — Posted on 2025-06-01
2460 Neuronal firing rate diversity lowers the dimension of population covariability
Tian, G. J.; Zhu, O.; Shirhatti, V.; Greenspon, C.; Downey, J. E.; Freedman, D. J.; Doiron, B.
10.1101/2024.08.30.610535 — neuroscience — Posted on 2025-06-01
2463 Leveraging autophagy and pyrimidine metabolism to target pancreatic cancer
Dufresne, S.; Kuna, R. S.; Wong, K.; Komarla, A.; Rock, A.; Rosada-Encarnacion, J.; Shen, C.; Mondal, P.; Parham, L. R.; Layng, F. I.; Peck, K. L.; Fowler, A.; Lowy, A. M.; Engle, D.; Tiriac, H.; Shaw, R.; Cosford, N.; Metallo, C.; Towers, C. G.
10.1101/2025.05.29.656904 — cancer biology — Posted on 2025-06-01
2469 Structure of a novel contractile injection system in subsp.
Ejaz, R. N.; Funke, K.; Kielkopf, C. S.; Martin, F. J. O.; Siborova, M.; Hendriks, I. A.; Sofos, N. H.; Pape, T. H.; Steiner-Rebrova, E. M.; Nielsen, M. L.; Erhardt, M.; Taylor, N. M. I.
10.1101/2025.06.01.657177 — microbiology — Posted on 2025-06-01
2470 Expanding the MR1 ligandome using chemical class-specific fragmentation and molecular networking
Lecchi, C.; Vacchini, A.; Sainas, S.; Lolli, M. L.; Luedtke, M. W.; Mori, L.; De Libero, G.; Balbo, S.; Villalta, P. W.
10.1101/2025.05.29.656472 — immunology — Posted on 2025-06-01
2472 Cone bipolar cell synapses generate transient versus sustained signals in parallel ON pathways of the mouse retina
Kuo, S. P.; Yu, W.-Q.; Srivastava, P.; Okawa, H.; Della Santina, L.; Berson, D. M.; Awatramani, G. B.; Wong, R. O.; Rieke, F.
10.1101/2024.05.13.593825 — neuroscience — Posted on 2025-06-01
2473 Phase-synchronized 40Hz tACS and iTBS effects on gamma oscillations
Glinski, B.; Salehinehjad, M. A.; Takahashi, K.; Jamil, A.; Yavari, F.; Kuo, M.-F.; Nitsche, M.
10.1101/2025.03.14.643227 — neuroscience — Posted on 2025-06-01
2474 EXOSC3 S1-domain variants implicated in PCH1b alter RNA exosome cap subunit abundance and thermal stability disrupting rRNA processing and targeting of AU-rich mRNA
Runnebohm, A. M.; Wijeratne, H. S.; Barron, M. P.; Smith-Kinnaman, W. R.; Rooney, J. D.; Peck Justice, S. A.; Cureton, L. A.; Holland, A.; Ghalei, H.; Pelletier, S.; Doud, E. H.; Vilseck, J. Z.; Mosley, A. L.
10.1101/2025.05.31.657176 — systems biology — Posted on 2025-06-01
2475 Voltage-dependent anion channels are mitophagy receptors mediating the recycling of depolarized mitochondria in Arabidopsis
MA, W.; MA, J.; ZHANG, K.; ZHENG, X.; WANG, P.; FENG, L.; MING, S.; ZHUANG, X.; ZHOU, J.; Gao, C.; KANG, B. H.
10.1101/2025.05.29.656919 — plant biology — Posted on 2025-06-01
2477 Complement factor D (adipsin) mediates pressure-pain hypersensitivity post destabilization of medial meniscus injury
Tjandra, P. M.; Andoko, B. A.; Kim, J. A.; Gomez, A. G.; Sar, S.; Aepala, M. R.; Pham, T. T. K.; Dumlao, D.; Welhaven, H. D.; Collins, K. H.
10.1101/2025.05.29.656852 — physiology — Posted on 2025-06-01
2479 Tumor-specific draining lymph node CD8 T cells orchestrate an anti-tumor response to neoadjuvant PD-1 immune checkpoint blockade
Honigsberg, R.; Cruz, T. D.; Yoffe, L.; Tang, M. S.; Ozgenel, D. O.; Markowitz, G.; Micheal, M.; Singh, A.; Altorki, N. K.; Elemento, O.; Villena-Vargas, J.
10.1101/2025.04.27.650862 — cancer biology — Posted on 2025-06-01
2480 MicroCT enables simultaneous longitudinal tracking of murine pancreatic cancer progression and cachexia
Pelz, K. R.; Jimenez, P.; Daniel, C. J.; Newton, S. D.; Cunningham, M.; Sears, R. C.; Worth, P. J.; Brody, J. R.; Zimmers, T. A.
10.1101/2025.05.29.656943 — cancer biology — Posted on 2025-06-01
2481 Chemotaxis of branched cells in complex environments
Liu, J.; Ron, J. E.; Rinaldi, G.; Williantarra, I.; Georgantzoglou, A.; de Vries, I.; Sixt, M.; Sarris, M.; Gov, N.
10.1101/2025.05.27.656457 — biophysics — Posted on 2025-06-01
2482 Single-molecule FRET and tracking of transfected biomolecules: multi-dimensional protein dynamics in living cells
Anandamurugan, A.; Eidloth, A.; Frank, V.; Wortmann, P.; Schrangl, L.; Lan, C.; Schuetz, G.; Hugel, T.
10.1101/2023.09.15.557875 — biophysics — Posted on 2025-06-01
2485 A photostable genetically encoded voltage indicator for imaging neural activities in tissue and live animals
Cao, C.; Zhu, R.; Zhou, S.; Zhao, Z.; Lin, C.; Liu, S.; Peng, L.; Subach, F. V.; Piatkevich, K. D.; Zou, P.
10.1101/2025.05.29.656768 — bioengineering — Posted on 2025-06-01
2487 The Na+-pumping mechanism driven by redox reactions in the NADH-quinone oxidoreductase from Vibrio cholerae relies on dynamic conformational changes
Ishikawa-Fukuda, M.; Seki, T.; Kishikawa, J.-i.; Takahiro, M.; Okazaki, K.-i.; Kato, T.; Barquera, B.; Miyoshi, H.; Murai, M.
10.1101/2025.06.01.656757 — biochemistry — Posted on 2025-06-01
2492 HIGH CO2 LEVELS OVERCOME THE NIGHTTIME LETHALITY OF CIRCADIAN MUTANTS IN CYANOBACTERIA
Mendana, A.; Santos-Merino, M.; Dominguez-Quintero, M.; Gutierrez-Lanza, R.; Ducat, D.; Fernandez-Lopez, R.
10.1101/2025.06.01.657271 — microbiology — Posted on 2025-06-01
2494 IFITM1 and IFITM3 cooperate to restrict virus entry in endolysosomes
Wilt, I.; Jolley, A. A.; Rahman, K.; Lai, K. K.; Shi, G.; Andresson, T.; Compton, A. A.
10.1101/2025.06.01.657267 — microbiology — Posted on 2025-06-01
2495 Macrophages Lacking TSC2 have mTORC1-dependent GPNMB Augmentation Ameliorating Cardiac Ischemia-Reperfusion Injury
Keykhaei, M.; Koleini, N.; Meddeb, M.; Tajdini, M.; Rezaee, M.; Huang, Q.; Panesar, T.; Adamo, L.; Ranek, M.; Kass, D. A.
10.1101/2025.05.29.656917 — immunology — Posted on 2025-06-01
2497 Developmentally-specific physiological and metabolic responses support drought resilience in switchgrass and constrains biofuel yield
Basyal, B.; Li, X.; Pargulski, V.; Fu, X.; Nightingale, N.; Overmyer, K.; Coon, J.; Zhang, Y.; Benucci, G. M. N.; Last, R.; Sato, T.; Walker, B.
10.1101/2025.05.29.656847 — plant biology — Posted on 2025-06-01
2501 Automated registration of spatial expression data scales multimodal integration to large cohorts
Harrigan, C. F.; Lam, C. Y.; Chen, D.; Lai, C.; Bremner, R. F.; Jackson, H. W.; Campbell, K.
10.1101/2025.05.29.656851 — bioinformatics — Posted on 2025-06-01
2504 A Temporal Single-Cell Multi-Omics Atlas of Murine Pancreatic Islet Remodeling During Hyperglycaemia Progression
Singh, S.; Pavan, M. K.; Barella, L. F.; Telang, J.; Shree, A.; Agarwal, S.; Goel, A.; Thaleshwar, S. i.; Wess, J.; Zafar, H.; Pydi, S. P.
10.1101/2025.05.29.656754 — genomics — Posted on 2025-06-01
2508 Developmental system drift in dorsoventral patterning is linked to transitions to autonomous development in Annelida
Carrillo-Baltodano, A. M.; Haillot, E.; Meha, S. M.; Luqman, I.; Pashaj, A.; Lee, Y.-J.; Lu, T.-M.; Ferrier, D. E. K.; Schneider, S. Q.; Martin-Duran, J. M.
10.1101/2025.05.29.656861 — developmental biology — Posted on 2025-06-01
2511 EXTENDING PROTEIN LANGUAGE MODELS TO A VIRAL GENOMIC SCALE USING BIOLOGICALLY INDUCED SPARSE ATTENTION
Dejean, T. L.; Ferrell, B. D.; Sawhney, R.; Harrigan, W.; Polson, S. W.; Wommack, K. E.; Belcaid, M.
10.1101/2025.05.29.656907 — bioinformatics — Posted on 2025-06-01
2513 Cell Type Specific Aging Transcriptional Signatures of Human Retina Through Integrated Machine Learning and Single-Cell Transcriptomics
Yang, L.; Lin, S.; Tao, Y.; Pan, Q.; Cai, T.; Ye, Y.; Liu, J.; Zhou, Y.; Shao, Y.; Yi, Q.; Lu, Z. H.; Chen, L.; McKay, G.; Rankin, R.; Li, F.; Meng, W.
10.1101/2025.05.29.656930 — bioinformatics — Posted on 2025-06-01
2518 Novel insights into the genome organization of Rhizobiaceae: identification of linear plasmids
Kuzmanovic, N.; Wick, R. R.; Kalita, M.; Pulawska, J.; DiCenzo, G. C.; Hynes, M. F.; Smalla, K.; Babin, D.; Thuenen, T.
10.1101/2025.05.29.656789 — genomics — Posted on 2025-06-01
2519 Single-cell Characterization of DNA Hydroxymethylation of the Mouse Brain During Aging
Bai, Y.; Yuan, T.; Ren, L.; Huan, Y.; Yang, F.; Li, Y.; Zhang, A.; Liu, Y.; Tian, T.; Kang, N.; Chen, D.; Xie, X.; Wang, Q.; Chen, W.; Zheng, Y.; Xie, X. S.; Cao, Y.
10.1101/2025.05.29.656780 — genetics — Posted on 2025-06-01
2520 From Synthetic to Biological Nitrification Inhibition: Advancing Stabilization of Organic Fertilizers
Vega-Mas, I.; Mancia, A.; Maggetto, L.; Murillo, H.; Debacq, A.; Heinesch, B.; Boland, F.; Krause, H.-M.; Vanderschuren, H.; Thonar, C.
10.1101/2025.05.29.656819 — plant biology — Posted on 2025-06-01
2522 Plastimos: a live cell imaging-based framework to study dynamics of EMT-mediated cellular plasticity in breast cancer
Hosseini, H.; Sameri, S.; Das, D.; Materna-Reichelt, S.; Stojanovic Guzvic, N.; Wöhrl, L.; Hoffmann, M.
10.1101/2025.05.28.656591 — bioinformatics — Posted on 2025-06-01
2524 Spatial metabolomics reveals persistent localized niche-specific metabolic failure in kidneys following ischemia-reperfusion injury
Rietjens, R. G. J.; Manzato, B.; van den Berg, B. M.; Mahfouz, A.; Giera, M.; Dumas, S. J.; Wang, G.; Rabelink, T. J.
10.1101/2025.05.27.656326 — biochemistry — Posted on 2025-06-01
2526 Host adaptation and genome evolution of the broad host range fungal rust pathogen, Austropuccinia psidii
Luo, Z.; Tobias, P.; Singh, L.; Dong, C.; Martino, A. M.; Quecine, M.; Massola Junior, N. S.; Silva, L. C. A.; Li, J.; Singh, S.; Zhang, Z.; Jones, A.; Park, R. F.; Schwessinger, B.; Edwards, R.; Boufleur, T.
10.1101/2025.05.29.656941 — microbiology — Posted on 2025-06-01
2527 Peptides alleviate cognitive impairment by inhibiting and disassembling amyloid-beta aggregates in Alzheimer disease
Gao, W.; Gao, B.; Wang, S.; Wu, D.; Mei, P.; Geng, L.; Li, C.; Li, Y.; Liu, X.; Pan, J.; Huang, J.; Deng, Y.; Chen, X.; saiyin, H.; Yu, H.; Li, S.; Zhang, Q.; Xu, B.; Huang, F.; Ming, C.; Wu, H.; Li, J.
10.1101/2025.05.28.656730 — neuroscience — Posted on 2025-06-01
2528 Rab2 and Arl8/BORC control retrograde axonal transport of dense core vesicles via Syd/dJIP3/4 and RUFY dynein adaptors
Lund, V. K.; Chirco, A.; Caliari, M.; Larsen, A. H.; Gether, U.; Madsen, K. L.; Wierer, M.; Kjaerulff, O.
10.1101/2025.05.28.656585 — neuroscience — Posted on 2025-06-01
2529 EEG reveals how space acts as a late heuristic of time
Doricchi, F.; Scozia, G.; Pinto, M.; Lozito, S.; Lo Presti, S.; Pazzaglia, M.; Silvetti, M.; Lasaponara, S.
10.1101/2025.05.28.656560 — neuroscience — Posted on 2025-06-01
2530 Lysosomal stress induces amyloid-β aggregate release and reactive transformation in human astrocytes
Goldsworthy, S.; Fertan, E.; Dyal, P.; Domoney, S.; Livesey, F.; Klenerman, D.; Patani, R.; Hung, C.
10.1101/2025.05.27.656416 — neuroscience — Posted on 2025-06-01
2531 Integrin-Specific Signaling Drives ER Stress-Dependent Atherogenic Endothelial Activation
Ben Dhaou, C.; Al-Yafeai, Z.; Cruz-Marquez, G. A.; Scott, M. L.; Pearson-Gallion, B.; Cockerham, E.; Li, H.; Peretik, J. M.; Hong, Y.; Dhanesha, N.; Yurdagul, A.; Rom, O.; Bhuiyan, M. S.; Orr, A. W.
10.1101/2025.05.31.654582 — pathology — Posted on 2025-06-01
2532 Population structure of Phytophthora infestans collected from potatoes in Guatemala and Honduras
Izarra, M. L.; Perez, W. G.; Vasquez, E. F.; Perez, G. E.; Gamboa, S.; Andrade-Piedra, J.; Flores, B.; Montejo, L.; Sanders, A.; Kreuze, J. F.
10.1101/2025.05.28.656702 — pathology — Posted on 2025-06-01
2533 KODAMA enables self-guided weakly supervised learning in spatial transcriptomics
Abdel-Shafy, E. A.; Kassim, M.; Vignoli, A.; Mamdouh, F.; Tyekucheva, S.; Ahmed, D.; Ojo, D.; Price, B.; Socciarelli, F.; Duarte-Delgado, N. P.; Ocharo, M.; Okeke, C. J.; Triboli, L.; MacIntyre, D. A.; Loda, M.; Sarkar, D.; Gupta, D.; Piazza, S.; Zerbini, L. F.; Tenori, L.; Cacciatore, S.
10.1101/2025.05.28.656544 — bioinformatics — Posted on 2025-06-01
2534 The clinical drug candidate anle138b binds predominantly to the central cavity in lipidic Aβ fibrils and modulates fibril formation.
Han, M.; Frieg, B.; Matthes, D.; Leonov, A.; Ryazanov, S.; Giller, K.; Nimerovsky, E.; Stampolaki, M.; Xue, K.; Overkamp, K.; Dienemann, C.; Riedel, D.; Giese, A.; Becker, S.; de Groot, B. L.; Schroeder, G.; Andreas, L. B.; Griesinger, C.
10.1101/2025.05.30.655790 — biochemistry — Posted on 2025-06-01
2535 Genomic signatures of climate-driven (mal)adaptation in an iconic conifer, the English yew (Taxus baccata L.)
Francisco, T.; Mayol, M.; Vajana, E.; Riba, M.; Westergren, M.; Cavers, S.; Pinosio, S.; Bagnoli, F.; Marchi, M.; Aravanopoulos, F. A.; Farsakoglou, A.-M.; Scotti, I.; Fady, B.; Vendramin, G. G.; Archambeau, J.; Piotti, A.; Gonzalez-Martinez, S. C.
10.1101/2025.05.29.656833 — genomics — Posted on 2025-06-01
2536 The XPF-like domain in SHOC1 required for homologous recombination and safeguarding autosome from meiotic silencing of unsynapsed chromatin
Zhang, Y.; Sun, Q.; Ji, Z.; Mo, R.; Zhou, Y.; Zhao, J.; Xu, S.; Li, N.; Sun, Y.; Bai, H.; Zhi, E.; Han, S.; Chen, H.; Zhang, J.; Qian, D.; Bu, X.; Huang, Y.; Tian, R.; Guo, Y.; Lv, J.; Zhao, L.; Yang, C.; Zhao, F.; Li, P.; Zhou, Z.; Li, Z.; Yao, C.
10.1101/2025.05.28.656576 — developmental biology — Posted on 2025-06-01
2539 Recovery of retinal terminal fields after traumatic brain injury: evidence of collateral sprouting and sexual dimorphism
Alexandris, A. S.; Yi, J.; Liu, C.; Belamarich, J.; Alam, Z.; Vats, A.; Peng, A.; Welsbie, D. S.; Zack, D. J.; Koliatsos, V. E.
10.1101/2025.05.28.656451 — neuroscience — Posted on 2025-06-01
2542 nanoPhos enables ultra-sensitive and cell-type resolved spatialphosphoproteomics
Oliinyk, D.; Heymann, T.; Henneberg, L.; Bardziukova, A.; Thielert, M.; Kjaergaard, J.; Vasconez, S.; Oeller, M.; Rodriguez, E.; Rosenberger, F. A.; Mann, M.
10.1101/2025.05.29.656770 — systems biology — Posted on 2025-06-01
2543 Body Fluid Proteomic Landscape of Acute Exercise
Kurgan, N.; Kjaergaard, J.; Jespersen, N. Z.; Diez-Obrero, V.; Moreno-Justicia, R.; Heywood, S. E.; Lindqvist, C. B.; Ottander, L.; Samodova-Sommer, D.; Nielsen, N. S.; Durrer, C. G.; Ried-Larsen, M.; Rasmussen, S.; Loos, R. J. F.; Smit, R. A. J.; Pedersen, B. K.; Deshmukh, A. S.
10.1101/2025.05.28.656705 — physiology — Posted on 2025-06-01
2544 Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis
Grimont, A.; Falvo, D. J.; Sisso, W. J.; Zumbo, P.; Chan, C. W.; Santos, F.; Pan, G.; Cleveland, M.; Yaron, T.; Osterhoudt, A. S.; Meng, Y.; Zafra, M. P.; Fall, W. B.; Rendeiro, A. F.; Hissong, E.; Yantiss, R. K.; Betel, D.; Magnuson, M. A.; Leach, S. D.; Rustgi, A. K.; Dow, L. E.; Chandwani, R.
10.1101/2025.05.28.656689 — cancer biology — Posted on 2025-06-01
2545 Robust statistical assessment of Oncogenotype to Organotropism translation in xenografted zebrafish
Saucier, D.; Jiang, X.; Rajendran, D.; Ravishankar, R.; Butler, E.; Marchetto, A.; Kurmasheva, R.; Gruenewald, T.; Amatruda, J.; Danuser, G.
10.1101/2025.05.28.656734 — cancer biology — Posted on 2025-06-01
2546 PAMD-Ch17, a Polymeric Analog of Plerixafor, Induces Mitochondrial Dysfunction in T-ALL Cells Independent of CXCR4
Lam, C.; Dhir, A.; Jogdeo, C. M.; Panda, S.; Kapoor, E.; Tang, S.; Rivero, V.; McIntyre, E. M.; Xiao, P.; Black, A. R.; Hewitt, K.; Swenson, S. A.; Romanova, S.; Oupicky, D.; Hyde, R. K.
10.1101/2025.05.28.656643 — cancer biology — Posted on 2025-06-01
2548 Targeted suppression of SPP1 inhibits tumor invasion and metastasis in NRF2 hyperactivated cisplatin resistant HNSCC
Kawabe, M.; Yang, S.; Bolanos, L. G.; Takamatsu, S.; Flores, S. A.; Castro, P. D.; Tsai, T.-Y.; Kaga, A. N.; Frederick, M. J.; Sandulache, V.; Kadara, H.; Myers, J. N.; Osman, A. A.
10.1101/2025.05.28.656679 — cancer biology — Posted on 2025-06-01
2550 Neural Spectral Prediction for Structure Elucidation with Tandem Mass Spectrometry
Wang, R.; Manjrekar, M.; Mahjour, B.; Avila-Pacheco, J.; Provenzano, J.; Reynolds, E.; Lederbauer, M.; Mashin, E.; Goldman, S. L.; Wang, M.; Weng, J.-K.; Plata, D. L.; Clish, C. B.; Coley, C. W.
10.1101/2025.05.28.656653 — bioinformatics — Posted on 2025-06-01
2553 Controllable Gap Junctions by Vitamin B12 and Light
Cui, D.; Liu, S.; Huang, X.; Tang, X. A.; Zheng, M.; He, Z.; Xu, R.; Sun, C.; Xu, Y.; Tu, R.; Zou, P.; Xie, T.; Sun, F.
10.1101/2025.05.28.656405 — bioengineering — Posted on 2025-06-01
2557 Projected warming disrupts embryonic development and hatch timing in Antarctic fish
Streeter, M. S.; Le Francois, N. R.; Desvignes, T.; Grondin, J.; Postlethwait, J. H.; Detrich, H. W.; Daane, J.
10.1101/2025.05.28.656708 — developmental biology — Posted on 2025-06-01
2559 SUSTAINED SYSTEMIC AND NEUROINFLAMMATION IN COGNITIVE DYSFUNCTIONAL FEMALE MICE AFTER NON-SEVERE EXPERIMENTAL MALARIA
Rosa-Goncalves, P.; Siqueira-e-Silva, B. N.; Lima, M. N.; Chagas, L. d. S.; de-Sousa, L. P.; Caputo, L. F. G.; da Silva, I. J.; dos Santos, J. P. R.; Evaristo, C. C. d. A.; Nogueira, M. d. S.; Werneck, G. L.; Ribeiro-Gomes, F. L.; Totino, P. R. R.; Pratt-Riccio, L. R.; Maron-Gutierrez, T.; de Almeida, R. F.; Machado, M. P.; Serfaty, C. A.; Daniel-Ribeiro, C. T.
10.1101/2025.05.28.656400 — immunology — Posted on 2025-06-01
2560 Hair follicle stem cell fate supports distinct clinical endotypes in Hidradenitis Suppurativa
Onfroy, A.; Jean-Louis, F.; Le Corvoisier, P.; Coulpier, F.; Muret, K.; Bonnet, E.; Arrouasse, R.; Boucle, C.; Abid, S.; Sbidian, E.; Bergqvist, C.; Wolkenstein, P.; Godot, V.; Deleuze, J.-F.; Levy, Y.; Topilko, P.; Audureau, E.; Hue, S.
10.1101/2025.05.28.656362 — immunology — Posted on 2025-06-01
2561 Microtubule anchoring and coupling of CD20 to the RhoA/Rock1 pathway
Klasener, K.; Lee, C. E.; Bender, J.; Naumann, A.; Reimann, L.; Andrieux, G.; Nitschke, R.; Warscheid, B.; Warnatz, K.; Voll, R. E.; Reth, M.
10.1101/2025.05.29.656301 — immunology — Posted on 2025-06-01
2562 Germline polymorphism in the immunoglobulin kappa and lambda loci explain variation in the expressed light chain antibody repertoire
Engelbrecht, E.; Rodriguez, O. L.; Lees, W.; Vanwinkle, Z.; Shields, K.; Schultze, S.; Gibson, W. S.; Smith, D. R.; Jana, U.; Saha, S.; Peres, A.; Yaari, G.; Smith, M. L.; Watson, C. T.
10.1101/2025.05.28.656470 — immunology — Posted on 2025-06-01
2563 Effects of Natural Lithium and Lithium Isotopes on Voltage Gated Sodium Channel Activity in SH-SY5Y and IPSC Derived Cortical Neurons
Bukhteeva, I.; Livingstone, J. D.; Singh, K.; Pavlov, E. V.; Beazely, M. A.; Gingras, M. J. P.; Leonenko, Z.
10.1101/2025.05.28.656602 — neuroscience — Posted on 2025-06-01
2564 Protective role of Cannabidiol against nicotine pouch-induced seizure aggravation and alterations in brain glymphatic biomarkers.
Bhandari, B.; Naeini, S. E.; Rogers, H. M.; Alhashim, A. H.; Yu, J. C.; Seyyedi, M.; Young, N.; Salles, E. L.; Wang, L. P.; Baban, B.
10.1101/2025.05.28.656668 — neuroscience — Posted on 2025-06-01
2566 Opposing effects of H2A.Z on memory, transcription and pathology in male and female Alzheimer's disease mice and patients
Luo, J. Q.; Hategan, L. A.; Creighton, S.; Hua, S.; McLean, T. A. B.; Dahi, T. A.; Jin, Z.; Pirri, F.; Winston, S. M.; Reeves, I. L.; Fahnestock, M.; Brimble, M. A.; Walters, B. J.; Murphy, P. J.; Zovkic, I.
10.1101/2025.05.28.656659 — neuroscience — Posted on 2025-06-01
2567 Pyruvate kinase activates SARM1 to exacerbate axonal degeneration in diabetic peripheral neuropathy
Liu, J.; Li, W.; Li, C.; Jiang, Y.; Zhu, W. J.; Zhang, Z.; Zhao, Y. J.; Lin, J.; YU, W.
10.1101/2025.05.28.656718 — neuroscience — Posted on 2025-06-01
2569 Twist and Snout: Head and Body Morphologies Determine Feeding Kinematics in Substrate-Biting Fishes
Perevolotsky, T.; Brotman-Krass, J. M.; Ratner, Y.; Avigad, Y.; Summers, A. P.; Donatelli, C. M.; Holzman, R.
10.1101/2025.05.28.656629 — zoology — Posted on 2025-06-01
2570 Integrating Alternative Fragmentation Techniques into Standard LC-MS Workflows Using a Single Deep Learning Model Enhances Proteome Coverage
Levin, N.; Saylan, C. C.; Lapin, J.; Demyanenko, Y.; Yang, K. L.; Sidda, J.; Nesvizhskii, A.; Wilhelm, M.; Mohammed, S.
10.1101/2025.05.28.656555 — systems biology — Posted on 2025-06-01
2571 Maternal control of RNA decay safeguards embryo development
Del Toro-De Leon, G.; Trenti, M. S.; Vasudevan, V.; Krause, U.; Köhler, C.
10.1101/2025.05.28.656625 — plant biology — Posted on 2025-06-01
2572 Galactan mobilization during carbon starvation compromises cell wall-mediated fungal resistance in Arabidopsis
Reckleben, L.; Morton, R. N.; Munzert-Eberlein, K. S.; Thiel, S.; Rautengarten, C.; Tan, V.; Harres, K. L.; Zanoni, L.; Ebert, B.; Engelsdorf, T.
10.1101/2025.05.28.656597 — plant biology — Posted on 2025-06-01
2573 OGDHL regulates nucleotide metabolism, tumor growth, and neuroendocrine marker expression in prostate cancer
Bernard, M.; Ruiz, A.; Diaz, J.; Nunley, N.; Dove, R.; Heering, K.; Bopardikar, S.; Gallardo, A.; Hashimoto, T.; Agrawal, R.; Smith, C.; Wilde, B.; Matulionis, N.; Richards, H.; Sharifi, M.; Lang, J.; Zhao, S.; Haffner, M.; Boutros, P. C.; Christofk, H.; Goldstein, A. S.
10.1101/2025.05.28.656673 — cancer biology — Posted on 2025-06-01
2578 LazySlide: accessible and interoperable whole slide image analysis
Zheng, Y.; Abila, E.; Chrenkova, E.; Winkler, J.; Rendeiro, A. F.
10.1101/2025.05.28.656548 — bioinformatics — Posted on 2025-06-01
2579 scExploreR: a flexible platform for democratized analysis of multimodal single-cell data by non-programmers
Showers, W.; Desai, J.; Gipson, S. R.; Engel, K. L.; Smith, C.; Jordan, C. T.; Gillen, A. E.
10.1101/2025.05.28.656649 — bioinformatics — Posted on 2025-06-01
2583 Benchmarking Software for DDA-PASEF Immunopeptidomics
Chen, Y.; Preikschat, A.; Arnold, A.; Pecori, R.; Gomez-Zepeda, D.; Tenzer, S.
10.1101/2025.05.28.656277 — bioinformatics — Posted on 2025-06-01
2584 Noninvasive Control of Seizure Threshold with Acoustically Targeted Chemogenetics
Li, H.; Nouraein, S.; Lee, S.; Link, S. S.; Raisely, E. K.; Szablowski, J. O.
10.1101/2025.05.28.656723 — bioengineering — Posted on 2025-06-01
2585 The SHR/Akr Y chromosome reveals repeated turnover of the rat pseudoautosomal region
Bellott, D. W.; Skaletsky, H.; Hughes, J.; Brown, L. G.; Pyntikova, T.; Cho, T.-J.; Koutseva, N.; Zaghlul, S.; Kizghin, D.; Mendoza, M.; Raudsepp, T.; Dugan, S.; Khan, Z.; Wang, Q.; Watt, J.; Worley, K. C.; Scherer, S.; Muzny, D. M.; Gibbs, R. A.; Page, D. C.
10.1101/2025.05.28.656580 — genomics — Posted on 2025-06-01
2586 SMURF Reconstructs Single-Cells from Visium HD Data to Reveal Zonation of Transcriptional Programs in the Intestine
Guo, J.; Sarafinovska, S.; Hagenson, R.; Valentine, M.; Dougherty, J.; Mitra, R. D.; Muegge, B. D.
10.1101/2025.05.28.656357 — genomics — Posted on 2025-06-01
2589 Viruses and vectors tied to honey bee colony losses
Lamas, Z.; Rinkevich, F.; Garavito, A.; Shaulis, A.; Boncristiani, D.; Hill, E.; Chen, Y. P.; Evans, J. D.
10.1101/2025.05.28.656706 — ecology — Posted on 2025-06-01
2591 Beneficial and detrimental consequences of AHR activation in intestinal infection
Diaz, O. P.; zhou, L.; Barrington, C.; Lindquist, D.; Graelmann, F.; Wincent, E.; Stockinger, B.
10.1101/2025.05.28.656570 — immunology — Posted on 2025-06-01
2592 Mind the Gap: Does Brain Age Improve Alzheimer's Disease Prediction?
Tan, T. W. K.; Nguyen, K.-N.; Zhang, C.; Kong, R.; Cheng, S. F.; Ji, F.; Chong, J. S. X.; Chong, E. J. Y.; Venketasubramanian, N.; Orban, C.; Chee, M. W. L.; Chen, C.; Zhou, J. H.; Yeo, B. T. T.; Alzheimer's Disease Neuroimaging Initiative, ; Australian Imaging Biomarkers and Lifestyle Study of Aging,
10.1101/2024.11.16.623903 — neuroscience — Posted on 2025-06-01
2593 A Movement-Independent Signature of Urgency During Human Perceptual Decision Making
McCone, H.; Devine, C. A.; McNickle, E.; Dully, J.; Geuzebroek, A. C.; McGovern, D. P.; Kelly, S. P.; O'Connell, R. G.
10.1101/2025.05.28.656559 — neuroscience — Posted on 2025-06-01
2594 Movement sonification during haptic exploration shifts emotional outcome without altering texture perception
Mouchnino, L.; Cornuault, P.-H.; Faucheu, J.; Witt, A.; Sutter, C.; Weiland, B.; Blouin, J.; Massi, F.; Chatelet, E.; Danna, J.
10.1101/2025.05.28.656569 — neuroscience — Posted on 2025-06-01
2597 Antibiotic resistance genes detected in lichens: insights from Cladonia stellaris
Alonso-Garcia, M.; George, P. B. L.; Leclerc, S.; Veillette, M.; Duchaine, C.; Villarreal, J. C.
10.1101/2025.05.28.656581 — plant biology — Posted on 2025-06-01
2598 Stochastic gates for covariate selection in population pharmacokinetics modelling
Kekic, M.; Stepanov, O.; Wang, W.; Richardson, S.; Olabode, D.; Traynor, C.; Dearden, R.; Zhou, D.; Tang, W.; Gibbs, M.; Nowojewski, A.
10.1101/2025.05.28.656586 — pharmacology and toxicology — Posted on 2025-06-01
2599 Membrane Interfacial Potential Governs Surface Condensation and Fibrillation of α-Synuclein in Neurons
Shaikh, J.; Nagarajan, A.; Mitra, T.; Modak, A. S.; Biswas, K.; Meher, G.; Bhausaheb, A. J.; Kannan, N. A.; Sahu, B. S.; Ghatak, S.; Choubey, S.; Saleem, M.
10.1101/2025.05.30.657012 — biophysics — Posted on 2025-06-01
2600 Cell attachment and tail contraction of S. aureus phage phi812
Binovsky, J.; Siborova, M.; Novacek, J.; Bardy, P.; Baska, R.; Skubnik, K.; Botka, T.; Benesik, M.; Pantucek, R.; Tripsianes, K.; Plevka, P.
10.1101/2024.09.19.613683 — microbiology — Posted on 2025-06-01
2602 Motor impairment and adaptation in a novel non-human primate model of internal capsule infarct
Sivakumar, S. S.; Anand, S. A.; Brawer, L.; Mellor, R. L.; Burkhalter, A.; Burton, H.; Brunner, P.; Bundy, D. T.; Leuthardt, E. C.; Moran, D. W.
10.1101/2025.05.27.656471 — neuroscience — Posted on 2025-06-01
2603 Reduced susceptibility to experimentally-induced complex visual hallucinations with age
Shenyan, O.; Haye, L.; Milne, G. A.; Lisi, M.; Greenwood, J. A.; Skipper, J. I.; Dekker, T. M.
10.1101/2025.05.27.656359 — neuroscience — Posted on 2025-06-01
2605 KODA: Agentic Framework for Microbiome Drug Target Discovery
Aminian-Dehkordi, J.; Parsa, M. S.; Naghipourfar, M.; Mofrad, M.
10.1101/2025.05.27.656480 — bioinformatics — Posted on 2025-06-01
2607 Application of Spectral Domain Optical Coherence Tomography To Guide Cochlear Implant Electrode Array
Jiramongkolchai, P.; Amaral, M. M.; Paul, R.; Matt, A.; Nie, M.; Hao, S.; Adkins, A.; Liang, H.; Holden, T.; Buchman, C.; Zhou, C.
10.1101/2025.05.27.656464 — bioengineering — Posted on 2025-06-01
2610 Vascular endothelial growth factor receptors 1 and 3 mediate placental trophoblast leptin production in preeclampsia, inducing vascular dysfunction
Elgazzaz, M.; Ogbi, S.; Moronge, D.; Mellott, E.; Cooper, G.; Backer, K.; Hitchings, J.; Zarate, L. V.; Kavuri, S.; Lee, T. J.; Ilatovskaya, D.; Woodham, P. C.; Maher, J.; Annex, B. H.; Faulkner, J. L.
10.1101/2025.05.27.656489 — physiology — Posted on 2025-06-01
2612 Rules of engagement: determinants of chemokine receptor activation and selectivity by CCL27 and CCL28
Huang, M.; Celniker, A. F.; Chitsazi, R.; Dyer, D. P.; Jansma, A. L.; Kufareva, I.; Salanga, C. L.; Handel, T.
10.1101/2025.05.27.656466 — pharmacology and toxicology — Posted on 2025-06-01
2613 In-Silico Characterization of TP53 Splice Mutations in Somatic and Germline Tumours
Bhandarkar, A. A.; Kelly-Foleni, N. E.; Sarkar, D.; Jeffs, A.; Slatter, T.; Braithwaite, A.; Mehta, S.
10.1101/2025.05.27.656522 — cancer biology — Posted on 2025-06-01
2614 Engineering Sustained-Release Broadly Neutralizing Antibody Formulations
Jons, C. K.; Kasse, C. M.; Mayer, B. T.; Hyrien, O.; Sen, S.; Meany, E. L.; d'Aquino, A. I.; Ganesh, P.; Eckman, N.; Dong, C.; Yan, J.; Nguyen, L. T.; Doulames, V. M.; Song, Y. E.; Saouaf, O. M.; Williams, C. M.; Williams, S. C.; Paredes, J.; Raghavan, R.; Palomares, M.; Alpert, M.; Yates, N. L.; Tomaras, G.; Seaman, M. S.; Farzan, M.; Appel, E. A.
10.1101/2025.05.27.656504 — bioengineering — Posted on 2025-06-01
2615 Female cortical cellular mosaicism underlies shared MeCP2 and PCB impacted gene pathways
Sharifi, O.; Neier, K. E.; Valenzuela, A. E.; Torres, C. G.; Korf, I.; Lein, P. J.; Yasui, D. H.; LaSalle, J.
10.1101/2025.05.28.655836 — systems biology — Posted on 2025-06-01
2617 Ketogenesis is dispensable for the metabolic adaptations to caloric restriction
Yeh, C.-Y.; Borgelt, L.; Vogt, B. J.; Clark, A. A.; Wong, T. T.; Grunow, I.; Sonsalla, M. M.; Babygirija, R.; Liu, Y.; Trautman, M. E.; Calubag, M. F.; Knopf, B. A.; Xiao, F.; Lamming, D.
10.1101/2025.05.29.656153 — physiology — Posted on 2025-06-01
2618 Multiscale Modeling Uncovers Macrophage Infiltration and TNF-α Signaling Networks for Targeting in Inflammatory Breast Cancer Tumor Emboli
PAI, P.; Van Berckelaer, C.; Van Laere, S.; Bennion, A.; Charity, T.; Yang, J.; Bertucci, F.; Van Dam, P.; Palmer, G. M.; McCall, S.; Dirix, L. Y.; Ueno, N. T.; Devi, G.
10.1101/2025.05.29.656249 — cancer biology — Posted on 2025-06-01
2619 Inter-tool analysis of a NIST dataset for assessing baseline nucleic acid sequence screening
Laird, T. S.; Flyangolts, K.; Bartling, C.; Gemler, B. T.; Beal, J.; Mitchell, T.; Murphy, S. T.; Berlips, J.; Foner, L.; Doughty, R.; Quintana, F.; Nute, M.; Treangen, T. J.; Godbold, G.; Ternus, K.; Alexanian, T.; Wheeler, N.; Forry, S. P.
10.1101/2025.05.30.655379 — bioinformatics — Posted on 2025-06-01
2621 Visualizing the Chronicle of Multiple Cell Fate using a Near-IR Dual-RNA/DNA-Targeting Probe
Sutrisno, L.; Richards, G. J.; Evans, J. D.; Matsumoto, M.; Li, X.; Uto, K.; Hill, J. P.; Taki, M.; Yamaguchi, S.; Ariga, K.
10.1101/2025.05.29.655717 — bioengineering — Posted on 2025-06-01
2625 The Kocurious case of Noodlococcus: genomic insights into Kocuria rhizophila from characterisation of a laboratory contaminant
McCallum, G. E.; Ho, S. F. S.; Cummins, E. A.; Wildsmith, A. J.; McInnes, R. S.; Weigel, C.; Tong, L. Y. S.; Quick, J.; van Schaik, W.; Moran, R. A.
10.1101/2025.05.28.656266 — genomics — Posted on 2025-06-01
2627 KLHL41 orchestrates sarcomere assembly and size to drive skeletal muscle hypertrophy in vivo
Han, H.; Shi, J.; Bongiorno, A. H.; Mansur, A.; Widrick, J.; Tate, G.; Gill, S.; Karimi, E.; Granzier, H.; Moore, J. R.; Gupta, V. A.
10.1101/2025.05.30.655367 — genetics — Posted on 2025-06-01
2628 A primate model organism for cardiac arrhythmias identifies a magnesium transporter in pacemaker function
Chang, S.; Karanewsky, C. J.; Pendleton, J. L.; Ren, L.; Anzeraey, A.; Froelicher, V.; Liang, D.; Razafindrakoto, A.; Ravelonjanahary, H. N.; Albertelli, M. A.; Quertermous, T.; Wright, P. C.; Perret, M.; Terrien, J.; Aujard, F.; Wu, J. C.; Krasnow, M. A.
10.1101/2025.05.28.655959 — genetics — Posted on 2025-06-01
2630 Rational design of respiratory syncytial virus dimeric F-subunit vaccines in protein and mRNA forms
Li, J.; Ma, X.; Xu, Z.; Guo, W.; Peng, R.; zhang, Y.; Meng, Y.; Wang, Q.; Li, S.; Chen, J.; Guo, Y.; Lu, X.; Wang, Q.; Guo, Y.; Jia, M.-a.; Li, Y.; Zhang, Y.; Li, S.; Du, P.; Wang, Q.; Gao, G. F.; Qi, J.
10.1101/2025.05.31.655981 — immunology — Posted on 2025-06-01
2631 Characterising Structural Brain Connectivity of Patients with First Episode of Psychosis
Sanchez, S. M.; Knösche, T.; Fürstova, P.; Skoch, A.; Spaniel, F.; Schmidt, H.; Hlinka, J.
10.1101/2025.05.30.656096 — neuroscience — Posted on 2025-06-01
2632 Dexmedetomidine produces more sleep-like brain activity compared to propofol
Krause, B. M.; Dappen, E. R.; Mueller, R. N.; Kawasaki, H.; Sanders, R. D.; Nourski, K. V.; Banks, M. I.
10.1101/2025.05.27.656383 — neuroscience — Posted on 2025-06-01
2633 Four-dimensional neural space for moral inference
Chen, J.; Santavirta, S.; Putkinen, V. J.; Boggio, P.; Nummenmaa, L.
10.1101/2025.05.28.656268 — neuroscience — Posted on 2025-06-01
2635 An atlas of TF driven gene programs across human cells
Pett, J. P.; Prete, M.; Pham, D.; England, N.; Yuan, H.; Prigmore, E.; Tuck, L.; Oszlanczi, A.; To, K.; Xu, C.; Suo, C.; Dann, E.; He, P.; Kedlian, V. R.; Kanemaru, K.; Cranley, J.; Yang, L.; Elmentaite, R.; Oliver, A. J.; Cujba, A.-M.; Cakir, B.; Murray, S.; Mahbubani, K. T.; Saeb-Parsy, K.; Gambardella, L.; Kasper, M.; Haniffa, M. A.; Nawijn, M. C.; Teichmann, S. A.; Meyer, K. B.
10.1101/2025.05.30.657075 — genetics — Posted on 2025-06-01
2636 Making new connections: An fNIRS machine learning classification study of neural synchrony in the default mode network
Miao, G. Q.; Lieberman, I. J.; Binnquist, A. L.; Pluta, A.; Goldstein, B. M.; Dale, R.; Lieberman, M. D.
10.1101/2025.05.31.656874 — neuroscience — Posted on 2025-06-01
2637 Encoding of speech modes and loudness in ventral precentral gyrus
Srinivasan, A.; Wairagkar, M.; Iacobacci, C.; Hou, X.; Card, N. S.; Jacques, B. G.; Pritchard, A. L.; Bechefsky, P. H.; Hochberg, L. R.; AuYong, N.; Pandarinath, C.; Brandman, D. M.; Stavisky, S. D.
10.1101/2025.05.30.657105 — neuroscience — Posted on 2025-06-01
2638 From Morphology to Computation: How Synaptic Organization Shapes Place Fields in CA1 Pyramidal Neurons
Tasciotti, S.; Iascone, D. M.; Chavlis, S.; Hammond, L.; Katz, Y.; Losonczy, A.; Polleaux, F.; Poirazi, P.
10.1101/2025.05.30.657022 — neuroscience — Posted on 2025-06-01
2639 Pupil responses to social stimuli are associated with adaptive behaviors across the first 24 months of life
Grzadzinski, R.; Carpenter, R. S.; Rutshon, J.; Jatkar, A.; Mata, K.; Bhatt, A.; Ortiz-Juza, M. M.; Dennehey, M. R.; Gilleskie, D. B.; Ellison, J.; Pegard, N.; Rodriguez-Romaguera, J.
10.1101/2025.05.30.656675 — physiology — Posted on 2025-06-01
2640 Cell-type-specific patterns and consequences of somatic mutation in development and aging brain
Kriz, A. J.; Mao, S.; Shao, D. D.; Snellings, D. A.; Andersen, R.; Dong, G.; Ma, C. C.; Cline, H. E.; Huang, A. Y.; Lee, E. A.; Walsh, C. A.
10.1101/2025.05.30.656844 — genomics — Posted on 2025-06-01
2641 Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model
Yokomizo, S.; Maci, M.; Stafford, A. M.; Miller, M. R.; Perle, S. J.; Takahashi, S.; Brown-Harding, H.; Liang, L.; Lovely, A.; Algamal, M.; Gillani, R. L.; Zwang, T. J.; Richardson, D.; Naegele, J. R.; Vogt, D.; Kastanenka, K. V.
10.1101/2025.05.31.656412 — neuroscience — Posted on 2025-06-01
2642 The mGluR5 Agonist, CHPG, Enhances Numbers of Differentiated Human Oligodendrocytes
Huang, Y.; Geywitz, C.; Bandaru, A.; Glass, I.; Birth Defects Research Laboratory, ; Schirmer, L.; Nobuta, H.; Dreyfus, C.
10.1101/2025.05.31.656838 — neuroscience — Posted on 2025-06-01