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Archive, 2025-06

3 The mechanistic basis of cargo selection during Golgi maturation
Taylor, R. J.; Zubkov, N.; Ciazynska, K. A.; Kaufman, J. G.; Tagiltsev, G.; Owen, D. J.; Briggs, J.; Munro, S.
10.1101/2025.06.26.661719 — cell biology — Posted on 2025-06-26
4 Nutrient-Responsive Formation of Mitochondrial-Derived Structures in Caenorhabditis elegans
Valera-Alberni, M.; Lanjuin, A.; Romero-Sanz, S.; Burkewitz, K.; Hughes, A.; Mair, W. B.
10.1101/2025.06.24.661357 — cell biology — Posted on 2025-06-26
6 Stiffness sensing fuels matrix-driven metabolic reboot for kidney repair and regeneration
Gui, Y.; Wang, Y.; Li, W.; Liu, J.-J.; Zheng, K.; Li, J.; Shaffer, H.; Jones, C.; Mallari, S.; Yu, Y.; Liu, S.; Liu, Y.; Zhou, D.
10.1101/2025.06.22.660927 — cell biology — Posted on 2025-06-26
7 Targeted p63 isoform switch corrects dominant mutations in AEC syndrome without disrupting epidermal homeostasis
Di Girolamo, D.; Urciuoli, G.; Sol, S.; Ferniani, M.; Antonini, D.; Marchese, E.; De Stefano, M. A.; Baltissen, M. P.; Ros, M. A.; Dixon, J.; Hadj-Rabia, S.; Missero, C.
10.1101/2025.06.24.661308 — molecular biology — Posted on 2025-06-26
10 Early transcriptional signatures of MeCP2 positive and negative cells in Rett syndrome
Li, Y.; Anderson, A. G.; Qi, G.; Wu, S.-R.; Revelli, J.-P.; Liu, Z.; Zoghbi, H. Y.
10.1101/2025.06.26.661761 — neuroscience — Posted on 2025-06-26
13 The AhR is a Critical Regulator of the Pulmonary Response to Cannabis Smoke
Wilson, E. T.; Gorgani, R.; Heimbach, N. S.; Bartolomucci, A.; Tsering, T.; Burnier, J. V.; Eidelman, D. H.; Baglole, C. J.
10.1101/2025.06.24.660596 — pharmacology and toxicology — Posted on 2025-06-26
14 Comprehensive investigation of SARS-CoV-2 intestinal pathogenesis in Drosophila
EL KAMALI, L.; NAGY, P.; GIRARD, J.; BUCHON, N.; MAVINGUI, P.; EL KALAMOUNI, C.; OSMAN, D.
10.1101/2025.06.25.661044 — pathology — Posted on 2025-06-26
15 Paclitaxel-induced mitotic arrest results in a convergence of apoptotic dependencies that can be safely exploited by BCL-XL degradation to overcome cancer chemoresistance
Qin, X.; Presser, A.; Johnson, L.; Matoba, Y.; Shay, B.; Xu, W.; Choiniere, J.; Fraser, C.; Garbicz, F.; Spetz, J. K. E.; Yu, S.; Florido, M. H. C.; Picucci, F.; Yang, Y.; Drapkin, R.; Hill, S. J.; Carrasco, D. R.; Liu, J.; Matulonis, U.; Brugge, J.; Rueda, B.; Zhou, D.; Stover, E.; Sarosiek, K.
10.1101/2025.06.24.661170 — cancer biology — Posted on 2025-06-26
18 Shear-Induced Macrophage Secretome Promotes Endothelial Permeability
Jui, E.; Kingsley, G.; Jimenez, S.; Birla, R. K.; Keswani, S.; Grande-Allen, K. J.
10.1101/2025.06.20.660831 — bioengineering — Posted on 2025-06-26
19 CellSpliceNet: Interpretable Multimodal Modeling ofAlternative Splicing Across Neurons in C. elegans
Afrasiyabi, A.; Kovalic, J.; Liu, C.; Castro, E.; Weinreb, A.; Varol, E.; Miller, D.; Hammarlund, M.; Krishnaswamy, S.
10.1101/2025.06.22.660966 — genetics — Posted on 2025-06-26
20 Genetic mapping of lifespan and mitochondrial stress response in C. elegans
Li, X.; Li, W.; Gao, A. W.; Zhu, Y.; Katsyuba, E.; Overmyer, K. A.; Li, T.; Wang, Z.; Legon, L.; Plantade, L.; Mouchiroud, L.; Cornaglia, M.; Li, H.; Houtkooper, R.; Auwerx, J.
10.1101/2025.06.26.661693 — genetics — Posted on 2025-06-26
21 Rapid genetic diversification of Bacteroides thetaiotaomicron in mono-associated mice revealed through deep population-level sequencing
Zioutis, C.; Lang, M.; Pereira, F. C.; Bochkareva, O. O.; Kolodyazhnaya, E.; Osvatic, J.; McCoy, K.; Künzel, S.; Fokt, H.; Baines, J. F.; Berry, D.
10.1101/2025.06.24.661302 — microbiology — Posted on 2025-06-26
22 Asymmetric increase in episodic and procedural memory interference in older adults
Celik, B.; Kamal, L.; Goldstein, D.; Alpert, G.; Gonzalez, S.; Nguyen, V.; Freedberg, M. V.
10.1101/2025.06.19.660650 — neuroscience — Posted on 2025-06-26
23 Comparative Systematic Analysis of Gray Matter BiophysicalModels on a Public Dataset
Mezzano, S.; Uhl, Q.; Pavan, T.; Nguyen-Du, J. N.-D.; Lee, H.; Huang, S.; Jelescu, I.
10.1101/2025.06.19.660512 — neuroscience — Posted on 2025-06-26
25 Scanning for Representation: A Scoping Review of Racial and Ethnic Diversity in MRI Studies of the Maternal Brain
Orchard, E. R.; Murray, C. L.; Wall, K. M.; Levy, J. C. P.; Shin, J. Y.; Gaebler, C. G.; Hart-Derrick, V. R.; Ayala, K.; Adodo, A.; Day, M. J.; Funaro, M. C.; Guan, K.; Parker, T. C.; Ricard, J. A.; Penner, F.; Yatziv, T.; Rutherford, H. J. V.
10.1101/2025.06.20.660240 — neuroscience — Posted on 2025-06-26
28 Neuromechanical Simulation with NEURON and MuJoCo
Fietkiewicz, C.; Tran, L.; McDougal, R.; Jackson, C.; Quinn, R. D.; Chiel, H. J.; Thomas, P. J.
10.1101/2025.06.17.660217 — neuroscience — Posted on 2025-06-26
33 miRNA/mRNA analysis of increased TGF-β pathways drive epithelial-mesenchymal transition and regulatory T cell differentiation
Darville, T.; Sun, X.; Zhang, Y.; O'Connell, C. M.; Mokashi, N.; Tang, W.; Bhardwaj, A.; Duncan, B.; Andrews, C. W.; Weisenfeld, H.; Zheng, X.
10.1101/2025.06.23.661210 — genomics — Posted on 2025-06-26
35 Expanding the utility of transcriptome analysis for mutation detection in high-risk childhood precision oncology
Mayoh, C.; Barahona, P.; Lin, A.; Cui, L.; Ajuyah, P.; Altekoester, A.; Lau, L. M.; Khuong-Quang, D.-A.; Sullivan, P.; Senapati, A.; Nagabushan, S.; Sullivan, A.; Omer, N.; Moore, A. S.; Nicholls, W.; Endersby, R.; Gottardo, N. G.; McCowage, G. B.; Dalla Pozza, L.; Hansford, J. R.; Khaw, S.-L.; Wood, P. J.; Trahair, T. N.; Marshall, G. M.; Ziegler, D. S.; Tyrrell, V.; Haber, M.; Wong, M.; Ekert, P. G.; Cowley, M. J.
10.1101/2025.06.25.661445 — genomics — Posted on 2025-06-26
36 The 3D architecture of the ctenophore aboral organ and the evolution of complex integrative centers in animals
Ferraioli, A.; Digel, L.; Sturm, D.; Colgren, J.; Le Goff, C.; Jan, A.; Soto-Angel, J. J.; Naumann, B.; Kittelmann, M.; Burkhardt, P.
10.1101/2025.06.26.659588 — evolutionary biology — Posted on 2025-06-26
37 Thyroid hormones act as a timer for the postnatal maturation of parvalbumin neurons in the neocortex
Ren, J.; Markossian, S.; Guyot, R.; Aubert, D.; Brocard, J.; Wong, J.; Flamant, F.; Richard, S.
10.1101/2024.12.13.628336 — developmental biology — Posted on 2025-06-26
38 A combination TLR7/8 and RIG-I agonist adjuvant reverts asthmatic allergic sensitization and prevents aggravated influenza infection in OVA-sensitized mice.
Diego, J. G.-B.; Burgess, E.; Chang, L. A.; Prellberg, M.; Noureddine, M.; Sadek, N.; Chen, Y.; El-Ayache, F.; Laghlali, G.; Park, S.-C.; Yan, V.; Wong, P. T.; De Geest, B. G.; Tomalka, J. A.; Schotsaert, M.
10.1101/2025.06.23.659362 — immunology — Posted on 2025-06-26
40 Tissue Factor Expression in Penile Squamous Cell Carcinoma: A Marker of HPV-Independent Disease
Jackson, J.; Johns, A.; Campos Clemente, L.; Manuel, C. M.; Qiao, W.; Lu, W.; Khan, K.; Solis Soto, L. M.; Chahoud, J.; Rao, P.; Campbell, M. T.; Pettaway, C. A.; Zacharias, N.
10.1101/2025.06.21.658950 — pathology — Posted on 2025-06-26
41 YAP signaling promotes resistance to MEK and AKT inhibition in NF1-related MPNSTs
McGee, L. E.; Grit, J. L.; Essenburg, C. J.; Agrusa, S.; Tovar, E. A.; Turner, L.; Becker, K.; Zbieg, J.; Dey, A.; Klomp, J. E.; Klomp, J. A.; Adams, M.; Beddows, I.; Wolfrum, E.; Fu, Z.; Hirbe, A. C.; Graveel, C. R.; Steensma, M. R.
10.1101/2025.06.16.659334 — cancer biology — Posted on 2025-06-26
42 Comprehensive Survey of Gut Microbiome Associations with Health Conditions in the Human Phenotype Project
Weissglas-Volkov, D.; Reisner, Y.; Shor, T.; Diament, A.; Jankelow, A.; Godneva, A.; Dhir, R.; Segal, E.
10.1101/2025.06.26.661672 — genomics — Posted on 2025-06-26
43 Mapping and reprogramming microenvironment-induced cell states in human disease using generative AI
Akbarnejad, A.; Steele, L.; Jafree, D. J.; Birk, S.; Sallese, M. R.; Rademaker, K.; Boxall, A.; Rumney, B.; Tudor, C.; Patel, M.; Prete, M.; Makarchuk, S.; Li, T.; Stanley, H.; Foster, A. R.; Roberts, K.; Trinh, A. L.; Villa, C. E.; Testa, G.; Mahil, S.; Mehrjou, A.; Smith, C.; Vakili, S.; Clatworthy, M. R.; Mitchell, T.; Bayraktar, O. A.; Haniffa, M.; Lotfollahi, M.
10.1101/2025.06.24.661094 — genomics — Posted on 2025-06-26
45 Towards Scalable Age-Grading of Aedes albopictus mosquito using Mid-Infrared Spectroscopy and Machine Learning
Foti, M.; Micocci, M.; Pazmino Betancourth, M.; Casas Gomez-Uribarri, I.; Serini, P.; Caputo, B.; della Torre, A.; Baldini, F.
10.1101/2025.06.20.660660 — ecology — Posted on 2025-06-26
46 Disease progression is associated with differential neutrophil maturation in Mycobacterium tuberculosis-infected macaques
Dinko, S. B.; Joly, C.; Mazet, P.; Sandillon, G.; Magneron, V.; Nunez, N.; Mayet, C.; Diry, S.; Gaspar, C.; Leonec, M.; Luccantoni, S.; Ludot, C.; Delache, B.; Jougla, E.; Morin, J.; Zouaoui-Frigui, W.; Brosch, R.; Contreras, V.; Galloüet, A.-S.; Bosquet, N.; Relouzat, F.; Pascal, Q.; Jean, B.; Holzapfel, M.; Lambotte, O.; Naninck, T.; Le Grand, R.; Lemaitre, J.
10.1101/2025.06.23.661022 — immunology — Posted on 2025-06-26
50 An Antagonistically Pleiotropic Gene Regulates Vertebrate Growth, Maturity and Aging
Moses, E.; Franek, R.; Atlan, T.; Chrzanowski, H.; Duxbury, E. M. L.; Kinreich, S.; Maklakov, A. A.; Harel, I.
10.1101/2023.05.01.538839 — genetics — Posted on 2025-06-26
53 Spatial dynamics of the tumor microenvironment associated with emerging resistance to targeted therapy in EGFR-mutated non-small cell lung cancer
Nakamura, S.; Shibahara, D.; Tanaka, K.; Kishikawa, Y.; Hashisako, M.; Nakatomi, K.; Nakagaki, N.; Kohno, M.; Azuma, K.; Ibusuki, R.; Otsubo, K.; Yoneshima, Y.; Iwama, E.; Oda, Y.; Okamoto, I.
10.1101/2025.02.10.637543 — cancer biology — Posted on 2025-06-26
54 RNA virus polymerase-helicase coupling enables rapid elongation throughduplex RNA
America, P.; BERA, S. C.; Das, A.; Anderson, T. K.; Marecki, J. C.; Papini, F. S.; Arnold, J. J.; Kirchdoerfer, R.; Cameron, C. E.; Raney, K. D.; Depken, M.; Dulin, D.
10.1101/2025.03.05.641625 — biophysics — Posted on 2025-06-26
55 Scale Invariance of Mechanical Properties in the DevelopingMammalian Retina
Shelton, E. R.; Frischmann, M.; Brinkop, A. T.; James, R. M.; Hüttl, L. M.; Serwane, F.
10.1101/2024.10.21.619491 — bioengineering — Posted on 2025-06-26
57 Context-Dependent Adaptation in Structured Environments
Karita, Y.; Rodriguez-Sanchez, G. T.; Brambilla, E.; Hernandez-Beltran, J. C. R.; Schwarz, M.; Rainey, P. B.
10.1101/2025.04.29.651346 — evolutionary biology — Posted on 2025-06-26
58 Inter-individual variability in immune responses to AAV-mediated ocular gene delivery across species impedes reliable immunomonitoring profile
REN, D.; CHAUVEAU, G.; VENDOMELE, J.; CABON, E.; PINEIRO, A.; VIGNAL-CLERMONT, C.; SALIBA, H.; RONZITTI, G.; GALY, A.; DALKARA, D.; PULMAN, J.; AIL, D.; FISSON, S.
10.1101/2025.06.02.656863 — immunology — Posted on 2025-06-26
60 NNMT drives innate sensitivity to NAMPT inhibition in YAP-dependent stem-like/ mesenchymal prostate cancer
Carreira, A. S. A.; Ciuffreda, M.; Thongon, N.; Haughey, C. M.; Pickard, A.; Eddie, S. L.; Steele, R. E.; Cerri, E.; Belli, R.; Peroni, D.; Facen, E.; Caffa, I.; Ghanem, M.; Nencioni, A.; Lunardi, A.; Tebaldi, T.; Mills, I.; Provenzani, A.
10.1101/2025.04.29.651153 — cancer biology — Posted on 2025-06-26
62 Hierarchical affinity landscape navigation through learning a shared pocket-ligand space
Feng, B.; Liu, Z.; Li, H.; Yang, M.; Zou, J.; Cao, H.; Li, Y.; Zhang, L.; Wang, S.
10.1101/2025.02.17.638554 — bioinformatics — Posted on 2025-06-26
63 Benchmarking Software for DDA-PASEF Immunopeptidomics
Chen, Y.; Preikschat, A.; Arnold, A.; Pecori, R.; Gomez-Zepeda, D.; Tenzer, S.
10.1101/2025.05.28.656277 — bioinformatics — Posted on 2025-06-26
64 16,000 combinatorial DNA rings">Assembling a true "Olympic Gel" from >16,000 combinatorial DNA rings
Speed, S.; Peng, Y.-H.; Atabay, A.; Gupta, K.; Müller, T.; Fischer, C.; Hermes, I. M.; Sommer, J.-U.; Lang, M.; Krieg, E.
10.1101/2024.07.12.603212 — bioengineering — Posted on 2025-06-26
65 Biodiversity modulates the cross-community scaling relationship in changing environments
Gjoni, V.; Altermatt, F.; Garnier, A.; Palamara, G. M.; Seymour, M.; Pontarp, M.; Pennekamp, F.
10.1101/2025.03.07.642014 — ecology — Posted on 2025-06-26
69 NERVE GROWTH FACTOR IS SUFFICIENT TO CAUSE MULTIPLE OSTEOARTHRITIS-RELEVANT PATHOLOGICAL FEATURES IN NAIVE MURINE KNEE JOINTS
Obeidat, A. M.; Newton, M. D.; Li, J.; Hu, B.; Ishihara, S.; Lammlin, L.; Junginger, L. M.; Farrell, E. C.; Ko, F. C.; Miller, R. J.; Scanzello, C. R.; Maerz, T.; Miller, R. E.; Malfait, A.-M.
10.1101/2025.06.20.660696 — neuroscience — Posted on 2025-06-26
70 Biocultural vulnerability of traditional crops in the Indian Trans Himalaya
Jaggi, H.; Anand, A.; Solari, K. A.; Echeverri, A.; Tobge, R.; Tsewang, T.; Suryawanshi, K.; Tuljapurkar, S. D.
10.1101/2024.10.22.619747 — plant biology — Posted on 2025-06-26
71 Scutellarin inhibits ferroptosis by promoting cellular antioxidant capacity through regulating the Nrf2 signaling
Yang, H.-y.; Chan, O.-k.; Huang, X.; Yan, L.; Sun, N.; Li, Y.-p.; Shi, Z.-j.; Zha, Q.-b.; Ouyang, D.-y.; Li, J.; He, X.-h.
10.1101/2025.06.20.660655 — pharmacology and toxicology — Posted on 2025-06-26
72 Host iron deficiency protects against Plasmodium infection and drives parasite molecular reprofiling.
Clucas, D.; Bennett, C.; Harding, R.; Pettikiriarachchi, A.; Baldi, A.; Randall, L. M.; Steel, R.; Mellin, R.; Hobbs, M.; Caiazzo, S.; Mwangi, M. N.; Fielding, K. L.; Hickey, P. F.; Baldwin, T. M.; Amann-Zalcenstein, D.; Emery-Corbin, S. J.; Mzembe, G.; Moya, E.; Braat, S.; Jex, A.; Demir, A. Y.; Verhoef, H.; Phiri, K. S.; Biggs, B.-A.; Tham, W.-H.; Boddey, J. A.; Pasricha, S.-R.; Ataide, R.
10.1101/2025.06.24.660981 — cell biology — Posted on 2025-06-26
73 Herpes simplex virus 1 strain 17+ with R2 mutation in UL37 has residual retrograde transport
Walter, M.; Haick, A. K.; Massa, P. A.; Klouser, L. M.; Stensland, L.; Santo, T. K.; Xie, H.; Jerome, K. R.
10.1101/2025.06.25.661543 — microbiology — Posted on 2025-06-26
74 Neural correlates of evidence accumulation in social-affective decision-making under perceptual ambiguity
Sun, S.; Xie, T.; Chen, Y.; Wang, J.; Li, X.; Yu, R.; Brunner, P.; Willie, J.; Wang, S.; Yu, H.
10.1101/2025.06.24.660932 — neuroscience — Posted on 2025-06-26
79 Melanocortin-responsive Kiss1 neurons of the arcuate nucleus drive energy expenditure through glutamatergic signaling to the dorsomedial hypothalamus.
Talbi, R.; Stincic, T. L.; Lynch, N.; Torres, E.; Ferrari, K.; Hae, C. J.; Medve, E.; Walec, K.; Zdon, S. T.; Pereira, S. A.; Mahoney, C. E.; Bosch, M. A.; Zweifel, L.; Ronnekleiv, O. K.; Machado, N. L. S.; Kelly, M. J.; Navarro, V. M.
10.1101/2025.06.25.661567 — neuroscience — Posted on 2025-06-25
80 Multiple autism genes influence GABA neuron remodeling via distinct developmental trajectories
Zoga, K.; Villiere, S.; Tikiyani, V.; Edwards-Cintron, A. F.; Thokachichu, P.; Nicodemus, P.; Camara, P. G.; Hart, M. P.
10.1101/2025.06.25.661546 — neuroscience — Posted on 2025-06-25
82 Stimulation modulates cell assemblies linked with gene networks in the human temporal cortex ex vivo
Moore, H.; Dehnad, M.; Freelin, A.; Granger, B.; Subramanian, S.; Kulkarni, A.; Berto, S.; Lega, B.; Konopka, G.
10.1101/2025.06.25.661589 — neuroscience — Posted on 2025-06-25
83 Spatial isoform sequencing at sub-micrometer single-cell resolution reveals novel patterns of spatial isoform variability in brain cell types
Michielsen, L.; Prjibelski, A. D.; Foord, C.; Hu, W.; Jarroux, J.; Hsu, J.; Tomescu, A. I.; Hajirasouliha, I.; Tilgner, H. U.
10.1101/2025.06.25.661563 — neuroscience — Posted on 2025-06-25
89 In-situ structures of the Legionella Dot/Icm T4SS identify the DotA-IcmX complex as the gatekeeper for effector translocation
Yue, J.; Heydari, S.; Park, D.; Chetrit, D.; Tachiyama, S.; Guo, W.; Botting, J. M.; Wu, S.; Roy, C. R.; Liu, J.
10.1101/2025.06.23.660953 — molecular biology — Posted on 2025-06-25
90 Uncovering the hidden diversity and functional roles of root endophytic Streptomyces under drought stress
Garcia, C. F.; Pettinga, D.; Caddell, D.; Ploemacher, H.; Louie, K.; Bowen, B.; Park, J.; Sanchez, J.; Zimic, A.; Traxler, M. F.; Northen, T.; Coleman-Derr, D.
10.1101/2025.06.25.661566 — microbiology — Posted on 2025-06-25
94 Oral octanoylcarnitine alleviates exercise intolerance in mouse models of long-chain fatty acid oxidation disorders
Solo, K. J.; Zhang, Y.; Bharathi, S.; Zhang, B. B.; Richert, A. C.; Schmidt, A. V.; Basu, S.; Van't Land, C.; D'Annibale, O.; Wood, T. C.; Vockley, J.; Goetzman, E. S.
10.1101/2025.06.24.661304 — biochemistry — Posted on 2025-06-25
95 Crosslinking by ZapD drives the assembly of short FtsZ filaments into toroidal structures in solution
Merino-Salomon, A.; Schneider, J.; Babl, L.; Krohn, J.-H.; Sobrinos-Sanguino, M.; Schäfer, T.; Luque-Ortega, J. R.; Alfonso, C.; Jimenez, M.; Jasnin, M.; Schwille, P.; Rivas, G.
10.1101/2023.01.12.523557 — biochemistry — Posted on 2025-06-25
102 Genetic potential for denitrification in SAR11 and other ubiquitous lineages of marine bacteria isolated from the northern Benguela Upwelling System
Morris, R. M.; Mattes, T. E.; Bubphamanee, K.; Sadler, M. C.; Calderaro, L. A.; Karolewski, J.; Casciotti, K. L.; Mason, O. U.
10.1101/2025.06.18.660415 — microbiology — Posted on 2025-06-25
105 Pentose Sugars Encode Sequence-Dependent DNA-RNA Segregation for Biomimetic Multiphase Condensates
Guo, W.; Chen, F.; Kinghorn, A. B.; Li, X.; Pan, Y.; Luo, R.; Wang, Y.; Lau, K. K.; Mao, T.; Wang, F.; Yang, Z.; Li, X.; Chen, Y.; Liu, S.; Zhang, Y.; Song, Y.; Zeng, X.; Shum, H. C.
10.1101/2025.06.23.656378 — biophysics — Posted on 2025-06-25
108 Genetically-programmed Hypervesiculation of Lactiplantibacillus plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model
Pirolli, N. H.; Levy, D.; Schledwitz, A.; Sampaio Moura, N.; Solomon, T. J.; Powsner, E. H.; Nowak, R.; Mamczarz, Z.; Bridgeman, C. J.; Khan, S.; Reus, L.; Anne, N.; Bentley, W. E.; Raufman, J.-P.; Jay, S. M.
10.1101/2025.06.20.660770 — bioengineering — Posted on 2025-06-25
110 Biocatalytic Construction of a CEST MRI Nucleoside Probe: Synthesis and Evaluation of 5-Methyl-5,6-dihydrothymidine
Al-Hilfi, A.; Franco, E. A. C.; Grady, C. J.; Mohanta, Z.; McMahon, M. T.; Bazayeva, M.; Li, Z.; Merz, K. M.; Gilad, A. A.
10.1101/2025.06.25.661137 — biochemistry — Posted on 2025-06-25
111 Evaluation of a prototype Orbitrap Astral Zoom mass spectrometer for quantitative proteomics - Beyond identification lists
Hsu, C.; Shulman, N.; Stewart, H.; Petzoldt, J.; Pashkova, A.; Plubell, D.; Denisov, E.; Hagedorn, B.; Damoc, E.; MacLean, B. X.; Remes, P. M.; Canterbury, J. D.; Makarov, A.; Hock, C.; Zabrouskov, V.; Wu, C. C.; MacCoss, M. J.
10.1101/2025.05.30.657132 — biochemistry — Posted on 2025-06-25
113 Item recognition is associated with gut microbiota composition in healthy humans
Oyarzun, J. P.; Kuntz, T. M.; Morgan, X. C.; Davachi, L.; Huttenhower, C.; LeDoux, J. E.; Phelps, E. A.
10.1101/2025.04.10.648258 — animal behavior and cognition — Posted on 2025-06-25
116 Mapping Fusarium Wilt and Sterility Mosaic Disease Resistance-Associated Genomic Regions and Haplotype Variants in Pigeonpea
Rangari, S. K.; Krishnappa, S.; Sharma, M.; Sharma, V. K.; Dube, N.; Gangurde, S. S.; Sharma, V.; Abbai, R.; Bomma, N.; Belliappa, S.; Bhutia, K. L.; Thudi, M.; Gangashetty, P. I.; Pandey, M. K.
10.1101/2025.06.19.660531 — genomics — Posted on 2025-06-25
117 Genomic analysis reveals the interplay between ABA-GA in determining dormancy duration in groundnut
Mohinuddin, D. K.; Gangurde, S. S.; Khan, H.; Bomireddy, D.; Sharma, V.; Shah, P.; Sagar, U. N.; Dube, N.; Senthil, R.; Tembhurne, B. V.; Nayak, V. H.; Amaregouda, A.; Babu, K.; Singh, K.; Janila, P.; Guo, B.; Liao, B.; Varshney, R. K.; Pandey, M. K.
10.1101/2025.06.20.660118 — genomics — Posted on 2025-06-25
121 Going green: Recycling transcriptomes to infer evolutionary relationships, gene duplication, gene tree conflict, and patterns of molecular evolution in the Apocynaceae
Arreguin, S.; Walker-Hale, N.; Casagrande, M. R.; Bishop, S.; Pugacewicz, E.; Ramizuddin, M.; Savitzky, C.; Morales, N.; Dhan, A.; Dybas da Natividade, B.; Madrid, V.; Simmons, C.; Diaz, A.; Ahmed, D.; Ho, Z.; Nieto Pellecer, J.; Diaz, S.; Mathew, T.; Mirshed, T.; Simon, B. M. M.; Thai, N.; Dufault-Hunter, S.; Hampton-Marcell, J.; Walker, J. F.
10.1101/2025.06.20.660724 — evolutionary biology — Posted on 2025-06-25
125 The transcriptomic signature of age and sex is not conserved in human primary myocytes
Lamon, S.; Soria, M.; Williams, R. M.; Critchlow, A.; Van Belleghem, K.; Garnham, A.; Varshney, A.; Beilharz, T.; Hiam, D.; Ziemann, M.
10.1101/2024.12.17.629041 — cell biology — Posted on 2025-06-25
126 Structural insights into DNA annealing and recombination by herpesviral DNA-binding proteins ICP8 and BALF2
Apte, G. R.; Patra, S.; Czarnocki-Cieciura, M.; Jabeen, A.; Jackiewicz, J.; Poznanski, J.; Nowotny, M.; Figiel, M.
10.1101/2025.06.25.661518 — molecular biology — Posted on 2025-06-25
127 Transglutaminase mediated crosslinking of pea protein: from rheology to proteomics
Mukherjee, A.; Van Pee, J.; Duijsens, D.; Grauwet, T.; Van de Voorde, I.; Fraeye, I.; Weiland, F.
10.1101/2025.06.24.661300 — molecular biology — Posted on 2025-06-25
128 Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency
Tiwari, V.; Jin, B.; Sun, O.; Lopez Gonzalez, E. D. J.; Chen, M.-H.; Wu, X.; Shah, H.; Zhang, A.; Herman, M. A.; Spracklen, C. N.; Goodman, R. P.; Brenner, C.
10.1101/2024.12.27.630525 — molecular biology — Posted on 2025-06-25
129 MTALTCO1: a 259 amino-acid long mtDNA-encoded alternative protein that challenges conventional understandings of mitochondrial genomics
Robitaille, F.; Campbell, A.; Ben Hadj, A.; Cornet, S.; Nadeau-Lachance, L.; Niaison, T.; Choquette, T.; Roucou, X.; Angers, A.; Breton, S.
10.1101/2024.09.22.614361 — molecular biology — Posted on 2025-06-25
131 Defining the minimal structural requirements of DivIVA in filamentous Actinomycetota
Lubbers, M.; Bajramovic, B.; Ongenae, V.; Willemse, J.; de Bruin, D.; Mulder, N.; Vriesendorp, B.; Barona-Gomez, F.; Briegel, A.; van Wezel, G.; Flardh, K.; Claessen, D.
10.1101/2025.06.24.661030 — microbiology — Posted on 2025-06-25
132 The Renin-Angiotensin System Modulates SARS-CoV-2 Entry via ACE2 Receptor
Gagliardi, S.; Hotchkin, T.; Tibebe, H.; Hillmer, G.; Marquez, D.; Izumi, C.; Chang, J.; Diggs, A.; Ezaki, J.; Suzuki, Y. J. J.; Izumi, T.
10.1101/2025.06.25.661409 — microbiology — Posted on 2025-06-25
134 Capsular specificity in temperate phages of Klebsiella pneumoniae is driven by diverse receptor-binding enzymes
Otwinowska, A.; Koszucki, J.; Panicker, V. R.; Leconte, J.; Olejniczak, S.; Holt, K.; Feil, E. J.; Rocha, E. P. C.; Smug, B.; Maciejewska, B.; Drulis-Kawa, Z.; Mostowy, R. J.
10.1101/2025.06.25.661490 — microbiology — Posted on 2025-06-25
135 Biogeochemical function of slicks in coastal surface waters of the Baltic Sea
Peter, C.; Giebel, H.-A.; Chai, B. C.; Serafim, T. S. G.; Lehners, C.; Wurl, O.; Osterholz, H.; Rahlff, J.
10.1101/2025.06.25.660598 — microbiology — Posted on 2025-06-25
136 Cell cycle dysregulation of globally important SAR11 bacteria resulting from environmental perturbation
Cheng, C.; Bennett, B. D.; Savalia, P.; Asrari, H.; Biel, C.; Evans, K. A.; Tang, R.; Thrash, C.
10.1101/2025.06.25.661606 — microbiology — Posted on 2025-06-25
138 Magnesium depletion unleashes two unusual modes of colistin resistancewith different fitness costs
Hsieh, Y.-Y. P.; O'Keefe, I. P.; Sun, W.; Wang, Z.; Yang, H.; Vu, L. M.; Ernst, R. K.; Dandekar, A. A.; Malik, H. S.
10.1101/2024.10.15.618514 — microbiology — Posted on 2025-06-25
139 Malassezia and the Asian menopausal skin
Davient, B.; Rikhraj, J. K.; Ravikrishnan, A.; Rozario, P.; Leong, C.; Mohamed Naim, A. N.; Chan, N.; The HELIOS Study Team, ; Common, J.; Chambers, J. C.; Yew, Y. W.; Loh, M.; Nagarajan, N.; Dawson, T. L.
10.1101/2025.06.24.660996 — microbiology — Posted on 2025-06-25
141 Neuropixels reveal structure-function relationships in monkey V1 in vivo
Carr, N.; Zhu, S.; Chen, X.; Lee, E. K.; Perliss, A.; Moore, T.; Chandrasekaran, C.
10.1101/2025.05.14.653875 — neuroscience — Posted on 2025-06-25
142 Individualized AI-driven neuromodulation enhances tongue motor and sensory control networks: a platform for neurorehabilitation in cancer survivors and patients with neurodegenerative disease.
Papageorgiou, T. D.; Webb, J.; Allam, A.; Reddy, S.; Huynh, D.; Hekmati, R.; Rohren, E. M.; Sturgis, E. M.; Hilsenbeck, S. G.; Heilbronner, S. R.; Hutcheson, K. A.; Thompson, A. M.; Neblett, C.; Froudarakis, E.
10.1101/2025.04.30.651533 — neuroscience — Posted on 2025-06-25
145 AKT2 modulates astrocytic nicotine responses in vivo.
Lombardi, A. M.; Griffioen, M.; Wong, H.; Milstead, R.; Borski, C.; Bower, M. E.; Shiely, E.; Schmitt, E.; LaPlante, L. E.; Ehringer, M. A.; Stitzel, J. A.; Hoeffer, C. A. A.
10.1101/2024.05.31.596856 — neuroscience — Posted on 2025-06-25
148 Cellular characterization of the mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cells
Zawieja, S. D.; Pea, G. A.; Broyhill, S. E.; Patro, A.; Bromert, K. H.; Norton, C. E.; Kim, H. J.; Sivasankaran, S. K.; Li, M.; Castorena-Gonzalez, J. A.; Drumm, B. T.; Davis, M. J.
10.1101/2023.08.24.554619 — physiology — Posted on 2025-06-25
149 Comparative Approaches for Quantification of Product Yield in the Production of Recombinant Green Fluorescent Protein (GFPuv) Expressed in E. coli
Rusch, G.; Wang, J.; Breau, K. A.; Kilgour, K.; Gilleskie, G.; Keele, J.; Selle, K.; Magness, S. T.; Menegatti, S.; Daniele, M.
10.1101/2024.06.24.600411 — biochemistry — Posted on 2025-06-25
154 Smooth muscle expression of RNA editing enzyme ADAR1 controls activation of RNA sensor MDA5 in atherosclerosis
Weldy, C. S.; Li, Q.; Monteiro, J. P.; Peters, T. S.; Guo, H.; Galls, D.; Gu, W.; Cheng, P. P.; Ramste, M.; Li, D. Y.; Palmisano, B. T.; Sharma, D.; Worssam, M. D.; Zhao, Q.; Bhate, A.; Kundu, R.; Nguyen, T.; Mokry, M.; Miller, C. L.; van der Laan, S. W.; Li, J. B.; Quertermous, T.
10.1101/2024.07.08.602569 — genomics — Posted on 2025-06-25
155 A protein complex in the extreme distal tip of vertebrate motilecilia controls their organization, length, and function
Hong, J.; Lee, C.; Madhu, G.; Papoulas, O.; Pan, J.; Takagishi, M.; Manzi, N.; Dickinson, D.; Horani, A.; Brody, S.; Marcotte, E.; Prakash, V. N.; Park, T. J.; Wallingford, J. B.
10.1101/2025.02.19.639145 — cell biology — Posted on 2025-06-25
158 SLAy-ing oversplitting errors in high-density electrophysiology spike sorting
Koukuntla, S.; DeWeese, T.; Cheng, A.; Mildren, R.; Lawrence, A.; Graves, A. R.; Colonell, J.; Harris, T. D.; Charles, A. S.
10.1101/2025.06.20.660590 — neuroscience — Posted on 2025-06-25
159 Multi-omics comparative analyses of synucleinopathy models reveal distinct targets and relevance for drug development
Lizama, B. N.; Shin, R.; North, H. A.; Look, G.; Reaver, A.; Pandey, K.; Duong, D.; Seyfried, N. T.; Caggiano, A. O.; Hamby, M. E.
10.1101/2025.06.20.660336 — neuroscience — Posted on 2025-06-25
161 Infection-Specific Reprogramming of Microglia Reveals Distinct Virulence Pathways Linking Periodontal Pathogens to Alzheimer's Disease
Kaminska, M.; Dudzinska, N.; Klapper, A.; Geissler, S.; Taudte, N.; Greiser, S.; Potempa, J.; Cynis, H.; Mydel, P.
10.1101/2025.06.06.658266 — neuroscience — Posted on 2025-06-25
167 3-Dimensional Piezoelectric Fibrous Constructs for Muscle Regeneration
Karagiorgis, X.; Balatsoukas, G.; Baghini, M. S.; Maung, M.; Zong, J.; Niar, S.; Kumar, C.; Rodrigo-Navarro, A.; Mulvihill, D. M.; Skabara, P. J.; Garcia Nunez, C.; Dobre, O.
10.1101/2025.06.19.660455 — bioengineering — Posted on 2025-06-25
172 Cell cycle-coupled transcriptional network orchestrates human B cell fate bifurcation
Pease, N. A.; Fan, J.; Keshari, S.; Stratton, J.; Gerges, P.; Ann Varghese, B.; Nampoothiri VP, N.; McGinnnis, C. S.; Zhang, W.; Gierlack, S. B.; Swaminathan, T.; Sachan, A.; Manakkat Vijay, G.; Mena Hernandez, L.; Heidari Rarani, Z.; Macedo, C.; Metes, D.; Satpathy, A. T.; Jain, A. K.; Sahni, N.; Stallaert, W.; Das, J.; Singh, H.
10.1101/2025.04.23.649973 — immunology — Posted on 2025-06-25
174 Functional recovery of the adult murine hippocampus after cryopreservation by vitrification
German, A.; Akdas, E. Y.; Fluegel-Koch, C.; Fejtova, A.; Winkler, J.; Alzheimer, C.; Zheng, F.
10.1101/2025.01.22.634384 — neuroscience — Posted on 2025-06-25
175 Does stimulus order affect central tendency and serial dependence in vestibular path integration?
Willemsen, S. C. M. J.; Oostwoud Wijdenes, L.; van Beers, R. J.; Koppen, M.; Medendorp, W. P.
10.1101/2025.06.20.660787 — neuroscience — Posted on 2025-06-25
176 Synergistic effects of APOE ϵ4 and Alzheimer's pathology on the neural correlates of episodic remembering in cognitively unimpaired older adults
Trelle, A. N.; Sheng, J.; Wilson, E. N.; Romero, A.; Park, J.; Deutsch, G. K.; Sha, S. J.; Greicius, M. D.; Andreasson, K. I.; Kerchner, G. A.; Mormino, E. C.; Wagner, A. D.
10.1101/2025.06.20.660774 — neuroscience — Posted on 2025-06-25
177 Maternal singing synchronizes the preterm infants' brain
Benis, D.; Margaria, J.; Barcos-Munoz, F.; Miehlbradt, J.; Lavezzo, L.; Grandjean, D.; Vollenweider, A.; Henriot, S.; Huppi, P. S.; Filippa, M.
10.1101/2025.06.24.660986 — neuroscience — Posted on 2025-06-25
178 Characterization of the BRAF interactome identifies BRAFV600E<=>TP53 interaction in melanoma
O'Toole, K. T.; Martinez, A.; Murphy, B.; Proveyeka, A.; Fort, G.; Al-Sudani, F.; Boggaram, S.; Paine, E. L.; Baral, D.; Andersen, J. L.; Parkman, G.; Snyder, E. L.; Judson-Torres, R.; McMahon, M.
10.1101/2025.06.20.660711 — cancer biology — Posted on 2025-06-25
184 Novel mouse model of cerebral microbleeds created by Crispr/Cas9-mediated Col4a1 deletion in adult brain microvessels
Kim, H.; Seo, Y.; Kho, H.; Singh, S. S.; Lee, J.; Lee, H.; Hwang, J.-W.; Riew, T.-R.; Koh, S.; Choi, J. Y.; Roh, H. W.; Son, S. J.; Kim, G. T.; Cho, S. K.; Jin, H.-S.; Jeong, S.-Y.; Lee, K. I.; Lee, J. Y.; Kim, B. G.
10.1101/2025.06.22.660900 — neuroscience — Posted on 2025-06-25
185 Harnessing cell-encapsulated hydrogels to study astrocyte mechanoresponse in 4D
Strat, A. N.; Patel, S.; Ho Thanh, M. T.; Kirschner, A.; Ghosh, S.; Geiss, M. P.; Viapiano, M.; Liu, Y.; Patteson, A. E.; Herberg, S.; Ganapathy, P. S.
10.1101/2025.06.20.660800 — neuroscience — Posted on 2025-06-25
189 Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntingtons disease pathogenesis in mice
Belgrad, J.; Summers, A.; Landles, C.; Greene, J. R.; Hildebrand, S.; Knox, E.; Sapp, E.; Yamada, N.; Furgal, R.; Miller, R.; Osborne, G. F.; Chase, K.; Luu, E.; Freedman, J.; Bramato, B.; McHugh, N.; Benoit, V.; OReilly, D.; Greer, P.; Bates, G. P.; Vogt, T. F.; Lee, R.; Howland, D.; DiFiglia, M.; Aronin, N.; Khvorova, A.
10.1101/2025.06.24.661398 — neuroscience — Posted on 2025-06-25
190 Spatially resolved mapping of histones reveal selective neuronal response in Rett syndrome
Lahiri, S.; Schäfer, F.; De Rocco, G.; Völker-Albert, M.; Forne, I.; Landsberger, N.; Imhof, A.
10.1101/2025.06.23.661075 — neuroscience — Posted on 2025-06-25
191 Contralesional grey matter volume as an index of macrostructural plasticity in patients with brain tumors
Manso-Ortega, L.; Gisbert-Munoz, S.; Amoruso, L.; Bermudez, G.; Gil-Robles, S.; Pomposo-Gastelu, I.; Carreiras, M.; Quinones, I.
10.1101/2025.06.24.661278 — neuroscience — Posted on 2025-06-25
192 A spatial atlas of chemoradiation therapy in pancreatic cancer identifies cellular and microenvironmental determinants of persister populations
Bernard, V.; Ku, L.-T.; Wang, T.; Acevedo-Diaz, A.; Rajapakshe, K. I.; Jacobson, G.; Tovar, D.; Min, J.; Pei, G.; Tat, C.; Suresh, A.; Tzeng, C.-W. D.; Katz, M. H.; Bhutani, M. S.; Wang, H.; Wolff, R. A.; Haymaker, C.; Ludmir, E. B.; Huang, H.; Chen, X.; Li, L.; Koong, A. C.; Wang, L.; Navin, N. E.; Jiang, D.; Li, Z.; Maitra, A.; Koay, E. J.
10.1101/2025.06.20.660757 — cancer biology — Posted on 2025-06-25
193 Phosphoinositide 3-kinase regulates wild-type RAS signaling to confer resistance to KRAS inhibition
Ge, X.; Singh, J.; Li, W.; Markham, C. S.; Ruiz, C. F.; Bhattacharyya, M.; Liu, Y.; Muzumdar, M. D.
10.1101/2025.06.20.660715 — cancer biology — Posted on 2025-06-25
199 Bird species with color polymorphism have greater ecological success
Kazuya, H.; Sato, E.; Sekercioglu, C. H.; Noriyuki, S.; Takahashi, Y.
10.1101/2025.06.19.660624 — ecology — Posted on 2025-06-25
202 The generation of viable, structurally integrated human-mouse chimaeras through enhanced hPSCs proliferation
Sato, H.; Yanagida, A.; Kasai, M.; Mizuno, N.; Mizutani, E.; Yamamoto, H.; Ishii, S.; Hihara, T.; Yamazaki, K.; Uchikura, A.; Nakano, K.; Ito, M.; Nagashima, H.; Masaki, H.; Nakauchi, H.
10.1101/2025.06.24.661270 — developmental biology — Posted on 2025-06-25
204 Beyond Pairwise Interactions: Charting Higher-Order Models of Brain Function
Santoro, A.; Neri, M.; Poetto, S.; Orsenigo, D.; Diano, M.; Gatica, M.; Petri, G.
10.1101/2025.06.24.661306 — neuroscience — Posted on 2025-06-25
205 MEGaNorm: Normative Modeling of MEG Brain Oscillations Across the Human Lifespan
Zamanzadeh, M.; Verduyn, Y.; de Boer, A. A. A.; Ros, T.; Wolfers, T.; Dinga, R.; Safar Postma, M.; Marquand, A. F.; van Wingerden, M.; Kia, S. M.
10.1101/2025.06.23.660997 — neuroscience — Posted on 2025-06-25
208 Autophagy activators normalize aberrant Tau proteostasis and rescue synapses in human familial Alzheimer's disease iPSC-derived cortical organoids
Labra, S. R.; Compher, J.; Prabhavalkar, A.; Almaraz, M.; Cedeno Kwong, C.; Baal, C.; Talantova, M.; Dolatabadi, N.; Pina-Sanz, J.; Wang, Y.; Yoon, L.; Ghatak, S.; Gao, Z.; Zhang, Y.; Trudler, D.; Massey, L.; Lin, W.; Balistreri, A.; Bula, M.; Mondala, T. S.; Schork, N. J.; Head, S. R.; Kelly, J. W.; Lipton, S. A.
10.1101/2025.06.25.661453 — neuroscience — Posted on 2025-06-25
212 A Deep Learning Framework for Predicting Functional Visual Performance in Bionic Eye Users
Skaza, J.; Murlidaran, S.; Varshney, A.; Wen, Z.; Wang, W.; Eckstein, M. P.; Beyeler, M.
10.1101/2025.06.23.660990 — neuroscience — Posted on 2025-06-25
215 Ocular delivery of different VCP inhibitory formulations prevents retinal degeneration in rhodopsin 255 isoleucine deletion mice
Cao, B.; Muehlfriedel, R.; Sen, M.; Almansa Garcia, A. C.; Seeliger, M.; Petremann-Dume, A.-S.; Kilger, E.; Vollert, A.; Bolz, S.; Henes, C.; Caliceti, P.; Salmaso, S.; Ueffing, M.; Arango-Gonzalez, B.
10.1101/2025.06.25.661245 — neuroscience — Posted on 2025-06-25
223 Bidirectional regulation of glycoprotein nonmetastatic melanoma protein B by β-glucocerebrosidase deficiency in GBA1 isogenic dopaminergic neurons from a patient with Gaucher disease and parkinsonism
Chen, C.; Ma, C.; Sam, R.; Lichtenberg, J.; Chen, T.; Hao, Y.; Li, Z.; Kowal, I.; Andersh, K.; Qi, Y. A.; Perez, G.; Hertz, E.; Li, Y.; Williams, D.; Henderson, M. J.; Park, M.; Jiang, X.; Jerez, P. A.; Blauwendraat, C.; Sidransky, E.; Chen, Y.
10.1101/2025.06.23.661126 — neuroscience — Posted on 2025-06-25
227 Cerebral vascular tortuosity and aneurysm formation and rupture: a novel vessel tortuosity scale
Knott, M. V.; Hamad, N.; Rodrigues, P. B.; Sanikommu, S.; Suon, J. S.; Hernandez-Cuervo, H.; Toledo, J.; Abdelsalam, A.; Eatz, T. A.; Del Brutto, V. J.; Luther, E. M.; Bhattacharya, S. K.; Hare, J. M.; Toborek, M.; Vazquez-Padron, R. I.; Thompson, J. W.; Starke, R. M.
10.1101/2025.06.24.661364 — neuroscience — Posted on 2025-06-25
229 Early life food insecurity impairs memory function during adulthood
Kao, A. E.; Moody, O. P.; Noble, E. E.; Myers, K. P.; Kanoski, S. E.; Hayes, A. M. R.
10.1101/2025.06.22.660913 — neuroscience — Posted on 2025-06-25
231 Kappa opioid receptors control a stress-sensitive brain circuit and drive cocaine seeking
Damonte, V. M.; Bailey, L. G.; Thakar, A.; Stralka, J.; Brown, T. E.; Kauer, J. A.
10.1101/2025.06.23.661181 — neuroscience — Posted on 2025-06-25
233 Peroxisomal import is circadian in glia and regulates sleep and lipid metabolism
Das, A.; Serna, I. M. R.; Kumar, A.; Kalita, H.; Sherpa, L.; Vaughen, J. P.; Bai, H.
10.1101/2025.06.23.661129 — neuroscience — Posted on 2025-06-25
240 Tropical montane and temperate hummingbirds incubate in small installments over long periods
Baldwin, J.; Munoz, M. A. L.; Sandoval-H., J.; Robinson, S. K.; Martinez, A.; Londono, G. A.
10.1101/2025.06.19.660382 — ecology — Posted on 2025-06-25
247 Fetal Dehydroepiandrosterone from Hair Samples at Birth Predicts Language Development
Reimann-Ayikoez, M.; Preiss, J.; Reisenberger, E.; Florea, C.; Angerer, M.; Schabus, M.; Roehm, D.; Schaadt, G.; Maennel, C.
10.1101/2025.06.24.661252 — developmental biology — Posted on 2025-06-25
248 Altered cognitive processes shape tactile perception in autism.
Semelidou, O.; Tortochot-Megne Fotso, M.; Winderickx, A.; Frick, A.
10.1101/2025.06.25.661477 — neuroscience — Posted on 2025-06-25
249 Tracing infant sleep neurophysiology longitudinally from 3 to 6 months: EEG insights into brain development
Beaugrand, M.; Jaramillo, V.; Muhlematter, C.; Schoch, S. F.; Reicher, V.; Markovic, A.; Kurth, S.
10.1101/2025.06.25.661476 — neuroscience — Posted on 2025-06-25
250 Single-Cell and Population-Level Neuromodulation Dynamics in Dual-Electrode Intracortical Stimulation
Kim, K.; Sonego, V.; Strohmer, B.; Chang, B.; Liu, X.; Yonza, A. K. I.; Kucharz, K.; Asiminas, A.; Lind, B. L.; Tao, L.; zhang, X.; Fried, S.; Han, A.; Cai, C.
10.1101/2025.06.25.661479 — neuroscience — Posted on 2025-06-25
254 Spatial transcriptomic profiling of human paravertebral sympathetic chain ganglia reveals diabetes-induced neuroplasticity
Moreno, M. M.; Patel, P.; Goss, K.; Mian, S. M.; Nakisli, S.; Inturi, N. N.; Shiers, S.; Horton, P.; Cervantes, A.; Funk, G.; Khan, T.; Vines, E.; Klein, R. M.; Henze, D. A.; Tavares-Ferreira, D.; Price, T. J.; Yousuf, M. S.
10.1101/2025.06.24.661373 — neuroscience — Posted on 2025-06-25
255 T-401 binding to monoacylglycerol lipase (MAGL) in the brains of patients and mice with temporal lobe epilepsy
Aripaka, S. S.; Pazarlar, B. A.; Pinborg, L. H.; Bonde-Larsen, K.; Gastambide, F.; Bang-Andersen, B.; Bastlund, J. F.; MIKKELSEN, J. D.
10.1101/2025.06.24.661388 — neuroscience — Posted on 2025-06-25
256 Genetically encoded nAChR upregulation is neuroprotective in female parkinsonian mice
Pandey, G.; Garcia, R. C.; Das, D.; Pollock, D.; Karthik, N.; Nalluri, S.; Nguyen, T.; Polo, C.; Zarate, S. M.; Srinivasan, R.
10.1101/2025.06.23.661175 — neuroscience — Posted on 2025-06-25
257 Oscillatory Control of Cortical Space as a Computational Dimension
Chen, Z.; Brincat, S. L.; Lundqvist, M.; Loonis, R. F.; Warden, M. R.; Miller, E. K.
10.1101/2025.06.24.661361 — neuroscience — Posted on 2025-06-25
259 Mosaic human cortical organoids model mTOR-related focal cortical dysplasia through DEPDC5 loss-of-function
Maletic, M.; Bizzotto, S.; Ribierre, T.; Guerdoud, K.; Raoux, C.; Doladilhe, M.; Dalle, C.; Picard, F.; Baulac, S.
10.1101/2025.06.25.661323 — neuroscience — Posted on 2025-06-25
260 EEG-GAN: A Generative EEG Augmentation Toolkit for Enhancing Neural Classification
Williams, C. C.; Weinhardt, D.; Hewson, J.; Plomecka, M. B.; Langer, N.; Musslick, S.
10.1101/2025.06.23.661164 — neuroscience — Posted on 2025-06-25
263 Lysosomal Enhancement Prevents Infection with PrPSc, α-Synuclein & Tau Prions
Mercer, R. C. C.; Le, N. T.; Mirza-Romero, N.; Flaherty, E.; Lavigna, G.; Orbe, I. C.; Gatdula, J. R. P.; Fraser, D. G.; Sundaravadivelu, A.; Vultaggio, J. S.; Beeler, A. B.; Chiesa, R.; Telling, G. C.; Harris, D. A.
10.1101/2025.06.24.661349 — neuroscience — Posted on 2025-06-25
264 ALE Meta-Analysis Reveals Neural Substrates for the Impact of Prematurity on Executive Functioning in Children and Adults
Youngkin, A. E.; Snetkov, G.; Grady, C.; Puglia, M. H.; Frazier, K.; Pelphrey, K. A.; Fairchild, K.; Goodkin, H. P.; Evans, T. M.
10.1101/2025.06.24.661281 — neuroscience — Posted on 2025-06-25
266 Evidence for divergent cortical organisation in Parkinsons disease and Lewy Body Dementia
Zarkali, A.; Thomas, G. E. C.; Hannaway, N.; Dobreva, I.; Grant-Peters, M.; Ryten, M.; Callaghan, M. F.; Weil, R. S.
10.1101/2025.06.25.661456 — neuroscience — Posted on 2025-06-25
267 TBRS-associated DNMT3A mutations disrupt cortical interneuron differentiation and neuronal networks
Chapman, G.; Determan, J.; Edwards, J. R.; Huettner, J. E.; Crump, S.; Jetter, H.; Gabel, H. W.; Kroll, K. L.
10.1101/2025.06.24.661324 — neuroscience — Posted on 2025-06-25
270 Altered therapeutic capacities of olfactory ensheathing cells caused by a lesion in an autologous transplantation model for the treatment of spinal cord injury.
Delarue, Q.; Brodier, M.; Neveu, P.; moncomble, L.; Raimond, C.; Robac, A.; Hugede, A.; Blondin, A.; Semprez, F.; Lecras, P.; Riou, G.; Guerout, N.
10.1101/2025.06.20.660789 — neuroscience — Posted on 2025-06-25
271 In vivo cartography of state-dependent signal flow hierarchy in the human cerebral cortex
Oh, Y.; Ann, Y.; Lee, J.; Ito, T.; Froudist-Walsh, S.; Paquola, C.; Milham, M.; Spreng, R. N.; Margulies, D.; Bernhardt, B.; Woo, C.-W.; Hong, S.-J.
10.1101/2025.06.24.660962 — neuroscience — Posted on 2025-06-25
276 Protein kinase CK2 alpha prime as a dual modulator of immune signaling and synaptic dysfunction in Tauopathy
White, A.; Gavrilyuk, P.; Falcon Moya, R.; Thurston, R.; Fickak, A.; Rozema, N. B.; Keshavaram, P.; Vermilyea, S.; Schlichte, R.; Meints, J.; Zhang, Y.; Araque, A.; Lee, M. K.; Gomez-Pastor, R.
10.1101/2025.06.24.661391 — neuroscience — Posted on 2025-06-25
278 Hydraulic Activation of the AsLOV2 photoreceptor
Maity, S.; Sheppard, J.; Russell, H.; Han, C.-T.; Epstein, L.; Johnson, B. A.; Price, B. D.; Han, R.; Potnuru, L. R.; Cui, J.; Sherwin, M. S.; Shea, J.-E.; Lovett, J. E.; Gardner, K. H.; Han, S.
10.1101/2025.06.19.660617 — biophysics — Posted on 2025-06-25
283 cpCST: A New Continuous Performance Test for High-Precision Assessment of Attention Across the Lifespan
MacKay-Brandt, A.; Garcia-Barnett, D.; Gan, K. X.; Ripley, O.; Gazes, Y.; Milham, M.; Colcombe, S. J.
10.1101/2025.06.22.660941 — animal behavior and cognition — Posted on 2025-06-25
284 ASC contributes to sustained glial reactivity and mild cognitive impairment after closed-head injury
Li, T.; Castro-Gomez, S.; Botella Lucena, P.; Vieira-Saecker, A.; Schwartz, S.; Deng, Y.; Ding, Y.; Stein, V.; Latz, E.; Heneka, M. T.
10.1101/2025.06.19.660521 — neuroscience — Posted on 2025-06-25
286 Tumor Cells Enriched for Interferon and Inflammatory Programs Pre-Exist in High Grade Serous Ovarian Cancer and are Proportionately Significantly Increased Post Chemotherapy
Winterhoff, B. J.; Girnius, N. A.; Liu, M.; Kang, J.; Shetty, M.; Martinez-Gakidis, M. A.; Xu, W.; Thomas, M.; Lahmadi, L.; Henstridge, A. Z.; Baldominos, P.; Talukdaer, S.; Chang, Z.; Mattson, J.; Gruner, M.; Mullany, S. A.; Argenta, P.; Konecny, G. E.; Slamon, D. J.; Drapkin, R.; Nelson, A. C.; Starr, T. K.; Brugge, J. S.
10.1101/2025.06.24.661404 — cancer biology — Posted on 2025-06-25
289 3-Dimensional Piezoelectric Fibrous Constructs for Muscle Regeneration
Karagiorgis, X.; Balatsoukas, G.; Baghini, M. S. S.; Maung, M.; Zong, J.; Niar, S.; Kumar, C.; Rodrigo-Navarro, A.; Mulvihill, D. M.; Skabara, P. J.; Garcia Nunez, C.; Dobre, O.
10.1101/2025.06.19.660455 — bioengineering — Posted on 2025-06-25
290 A mouse model of PTEN Hamartoma Tumour Syndrome reveals that loss of the nuclear function of PTEN drives macrocephaly, lymphoid overgrowth, and late-onset cancer
Tibarewal, P.; Rathbone, V.; Conduit, S.; Classen, G. A. E.; Black, F.; Danesh, M. A.; Constantinou, G.; Asgarian, Z.; Tohyama, K.; Nisha, N.; Alvarez Garcia, V.; Foxall, E.; Belarbi, D.; Leverve, M.; Pearce, W.; Adil, M.; Varyova, Z.; Conde, L.; Alves, A.; Masson, G.; Williams, R. L.; Flanagan, A. M.; Herrero, J.; Stroud, K.; Tischkowitz, M.; Lachlan, K.; Scott, M.; Leslie, N.; Kessaris, N.; Vanhaesebroeck, B.
10.1101/2025.06.20.660297 — genetics — Posted on 2025-06-25
293 Status of Florida's pillar coral population: in situ declines and ex situ successes
Neely, K. L.; Morgan, R.; O'Neil, K.; Cox, N.; Gilliam, D.; Mair, M.; Walker, B. K.; Zummo, A.; Harrell, C.; Ellis, A.
10.1101/2025.06.19.660574 — ecology — Posted on 2025-06-25
298 Disrupted Energy Landscape in Individuals with Mild Cognitive Impairment: Insights from Network Control Theory
Neumann, D. L.; Razlighi, Q.; Stern, Y.; Devanand, D. P.; Jamison, K.; Kuceyeski, A.; Tozlu, C.
10.1101/2025.06.19.660545 — neuroscience — Posted on 2025-06-25
299 Towards Optimizing Target Engagement in Non-Invasive Trigeminal Nerve Stimulation: Anatomical Characterization and Computational Modeling of the Human Trigeminal Nerve
Perrault, J. L.; Kozma, K. D.; Zeng, W.; Nkana, Z.; Albano, N. J.; Gunderson, K. A.; Hurley, S. A.; Lake, W. B.; Williams, J. C.; Poore, S. O.; Ludwig, K. A.; Dingle, A. M.; Suminski, A. J.
10.1101/2025.06.19.660375 — neuroscience — Posted on 2025-06-25
300 The synergistic interactions of low-dimensional brain modes
Herzog, R.; Vohryzek, J.; Luppi, A.; Geli, S.; Kringelbach, M. L.; Tagliazucchi, E.; Deco, G.; Sanz-Perl, Y.
10.1101/2025.06.19.660516 — neuroscience — Posted on 2025-06-25
303 A pre-menopausal single-cell atlas for ovarian drug discovery
VanBenschoten, H.; Nugmanova, Z.; Olmsted, A. M.; Gingerich, I.; Kratka, C.; Huang, R.; Duncan, F.; Kholod, O.; Goods, B.
10.1101/2025.06.20.660779 — bioinformatics — Posted on 2025-06-25
304 All-Atom Protein Sequence Design using Discrete Diffusion Models
Villegas-Morcillo, A.; Admiraal, G. J.; Reinders, M. J. T.; Weber, J. M.
10.1101/2025.06.13.659451 — bioinformatics — Posted on 2025-06-25
305 The AlphaFold Database Ages
Tsitsa, I.; Conev, A.; David, A.; Islam, S. A.; Sternberg, M. J. E.
10.1101/2025.06.22.660930 — bioinformatics — Posted on 2025-06-25
307 De novo designed bright, hyperstable rhodamine binders for fluorescence microscopy
Chen, Y.; Yserentant, K.; Hong, K.; Kuang, Y.; Bhowmick, A.; Charles-Orszag, A.; Lord, S. J.; Lu, L.; Hou, K.; Mann, S. I.; Grimm, J. B.; Lavis, L. D.; Mullins, R. D.; DeGrado, W. F.; Huang, B.
10.1101/2025.06.24.661379 — bioengineering — Posted on 2025-06-25
311 Hicberg: Reconstruction of contact signals from repeated elements
Gradit, S.; Ortion, S.; Larrous, P.; Delouis, M.; Koszul, R.; Cournac, A.
10.1101/2025.06.20.660295 — genomics — Posted on 2025-06-25
314 Sequential PIDD1 auto-processing is essential for ploidy control in liver and heart
Eichin, F.; Sladky, V. C.; Reiner, M.; Leone, M.; Abila, E.; Rendeiro, A. F.; Dahlhoff, M.; Kolbe, T.; Boettcher, R.; Villunger, A.
10.1101/2025.06.23.660994 — cell biology — Posted on 2025-06-25
316 Characterization of cellular wound resistance in the giant ciliate Stentor coeruleus
Paul, R.; Nadkarni, A. V.; Sipkova, J.; Sato, J. E.; Zhang, K. S.; Barone, V.; Marshall, W. F.; Tang, S. K. Y.
10.1101/2025.06.23.661154 — cell biology — Posted on 2025-06-25
318 InDels in an intronic region of gene Ccsmd04 coding for dormancy/auxin-associated protein controls sterility mosaic disease resistance in pigeonpea
Rangari, S. K.; Dube, N.; Sharma, V.; Gangurde, S. S.; Sharma, M.; Gangashetty, P. I.; Saxena, R. K.; Moghiya, A.; Sharma, V. K.; Bhutia, K. L.; Kant, R.; Thudi, M.; Naik SJ, S.; Pratap, A.; Dixit, G. P.; Mayes, S.; Pandey, M. K.
10.1101/2025.06.19.660552 — genomics — Posted on 2025-06-25
321 Intracellular pH dynamics respond to extracellular matrix stiffening and mediate vasculogenic mimicry through β-catenin
Lund, L. M.; Marchi, A. N.; Alderfer, L.; Hall, E. A.; Hammer, J.; Moremen, R.; Asilebo, I.; Trull, K. J.; Hanjaya-Putra, D.; White, K. A.
10.1101/2024.06.04.597454 — cell biology — Posted on 2025-06-25
322 Image-based profiling of healthy donor immune cells with Blood Cell Painting reveals novel genotype-phenotype associations
Hogel-Starck, C.; Timonen, V. A.; Atarsaikhan, G.; Mogollon, I.; Polso, M.; Hassinen, A.; Honkanen, J.; David Sarmento, C.; Koski, J.; Soini, J.; Urpa, L.; Ruokoranta, T.; Ahlnas, T.; Juvila, J.; Miettinen, J. J.; Rodosthenous, R.; FinnGen, ; Kilpivaara, O.; Arvas, M.; Heckman, C. A.; Partanen, J.; Daly, M.; Palotie, A.; Ollila, H. M.; Paavolainen, L.; Pietiainen, V.; Pitkanen, E.
10.1101/2024.05.17.594648 — cell biology — Posted on 2025-06-25
324 Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer's disease retina
Gaire, B. P.; Koronyo, Y.; Vit, J.-P.; Hutton, A.; Swerdlow, N.; Fuchs, D.-T.; Rentsendorj, A.; Shahin, S.; Subedi, L.; Robinson, E.; Ljubimov, A. V.; Schneider, L. S.; Hawes, D.; Graham, S. L.; Gupta, V. K.; Mirzaei, M.; Black, K. L.; Meyer, J. G.; Arditi, M. A.; Crother, T. R.; Koronyo-Hamaoui, M.
10.1101/2025.06.19.660619 — neuroscience — Posted on 2025-06-25
327 Unraveling Resistance and Thresholds in Phage Therapy Using Staphylococcus aureus In Vitro Models
Royet, K.; Blazere, L.; Helluin, E.; Coignet, L.; Plumet, L.; Bonhomme, M.; Kolenda, C.; Garreau, R.; Valour, F.; Medina, M.; Laurent, F.; Goutelle, S.
10.1101/2025.04.25.650594 — pharmacology and toxicology — Posted on 2025-06-25
328 MYD88 mutations in clonal hematopoiesis promote inflammation and hematopoietic stem cell expansion
Yeung, J.; Philbrook, S. Y.; Uible, E.; Lee, L.; Choi, K.; Agarwal, P.; Clough, C. A.; Patel, P.; Wikenheiser-Brokamp, K. A.; Hueneman, K.; Reinhardt, H. C.; Doong, T.-J.; Lozanski, A.; Lozanski, G.; Haque, T.; Hertlein, E.; Byrd, J. C.; Starczynowski, D. T.
10.1101/2025.06.19.660202 — cancer biology — Posted on 2025-06-25
331 Obesity promotes conserved inflammatory and metabolic transcriptional programs in mouse and human colon tumors
Glenny, E. M.; Lin, T.; Bandera, V. M.; Mirminachi, B.; Khumukcham, S. S.; Gigic, B.; Warby, C. A.; Aksonova, O.; Coleman, M. F.; Carpanese, A.; Busch, C.; Himbert, C.; Ose, J.; Nix, D. A.; Boucher, K.; Schirmacher, P.; Strehli, I.; Hardikar, S.; Cohan, J. N.; Jedrzkiewicz, J.; Brobeil, A.; Schneider, M. A.; Kahlert, C.; Siegel, E. M.; Byrd, D. A.; Toriola, A. T.; Shibata, D.; Li, C. I.; Figueiredo, J. C.; Tan, A. C.; Roper, J.; Ulrich, C. M.; Hursting, S. D.
10.1101/2025.06.19.660576 — cancer biology — Posted on 2025-06-25
332 Tumbleweed: an artificial motor protein that walks along a DNA track
Nilsson, P.; Robertson, N. O.; Gustafsson, N.; Davies, R.; Liew, C.; Lyons, A.; Eichhorn, R.; Niman, C.; Blab, G.; Bromley, E.; Whitten, A. E.; Duff, A.; Unksov, I. N.; Beech, J.; Jönsson, P.; Böcking, T.; Höcker, B.; Woolfson, D.; Forde, N. R.; Linke, h.; Curmi, P.
10.1101/2025.03.07.641123 — biophysics — Posted on 2025-06-25
334 Scalable data harmonization for single-cell image-based profiling with CytoTable
Bunten, D.; Tomkinson, J.; Serrano, E.; Lippincott, M. J.; Brewer, K. I.; Rubinetti, V.; Alquaddoomi, F.; Way, G. P.
10.1101/2025.06.19.660613 — bioinformatics — Posted on 2025-06-25
338 Serum Lewis fucosylation reports on survivorship of patients with septic shock upon admission to intensive care unit
Chau, T. H.; Chatterjee, S.; Caulfield, L.; Chernykh, A.; Traini, M.; Hwang, H.; Kawahara, R.; Meyer, E. J.; Torpy, D. J.; Thaysen-Andersen, M.
10.1101/2025.06.23.661221 — biochemistry — Posted on 2025-06-25
339 Decoupling of emigration timing and skill acquisition in a saturated population of golden eagles
Bronnvik, H.; Scacco, M.; Chimento, M.; Bassi, E.; Fiedler, W.; Hatzl, J. S.; Sumasgutner, P.; Tschumi, M.; Wikelski, M.; Zimmermann, S.; Safi, K.; Nourani, E.
10.1101/2025.04.21.649390 — animal behavior and cognition — Posted on 2025-06-25
340 Genomic Foundationless Models: Pretraining Does Not Promise Performance
Vishniakov, K.; Viswanathan, K.; Medvedev, A.; Kanithi, P.; Pimentel, M. A.; Rajan, R.; Khan, S.
10.1101/2024.12.18.628606 — genomics — Posted on 2025-06-25
342 The population genetics of biological noise
Weinreich, D. M.; Sgouros, T.; Raynes, Y.; Burtsev, H.; Chang, E.; Rajakumar, S.; Bravo, I. G.; Petak, C.
10.1101/2025.01.11.632402 — evolutionary biology — Posted on 2025-06-25
343 The economic strategies of superorganisms
Leahy, L.; Riskas, H. L.; Halliwell, B.; Wright, I. J.; Carlesso, A. G.; Sanders, N. J.; Bishop, T. R.; Parr, C. L.; Chown, S. L.; Shik, J. Z.; Andersen, A. N.; Gibb, H.
10.1101/2025.02.21.639603 — ecology — Posted on 2025-06-25
345 Neutralizing human monoclonal antibodies that target the PcrV component of the Type III Secretion System of Pseudomonas aeruginosa act through distinct mechanisms
Desveaux, J.-M.; Faudry, E.; Contreras-Martel, C.; Cretin, F.; Dergan-Dylon, L. S.; Amen, A.; Bally, I.; Tardivy-Casemajor, V.; Chenavier, F.; Fouquenet, D.; Caspar, Y.; Attree, I.; Dessen, A.; Poignard, P.
10.1101/2024.10.19.619220 — microbiology — Posted on 2025-06-25
346 The unique synaptic circuitry of specialized olfactory glomeruli in Drosophila melanogaster
Gruber, L.; Cantera, R.; Pleijzier, M. W.; Steinert, M.; Pertsch, T.; Hansson, B. S.; Rybak, J.
10.1101/2022.09.30.510181 — neuroscience — Posted on 2025-06-25
347 RubyACRs Enable Red-Shifted Optogenetic Inhibition in Freely Behaving Drosophila
Bushey, D.; Shiozaki, H. M.; Shuai, Y.; Zheng, J.; Jayaraman, V.; Kolb, I.; Hasseman, J. P.; GENIE Project Team, ; Turner, G. C.
10.1101/2025.06.13.659144 — neuroscience — Posted on 2025-06-25
348 Global Neuron Shape Reasoning with Point Affinity Transformers
Troidl, J.; Knittel, J.; Li, W.; Zhan, F.; Pfister, H.; Turaga, S. C.
10.1101/2024.11.24.625067 — neuroscience — Posted on 2025-06-25
349 The cost of cognition: Measuring the energy consumption of non-equilibrium computation
Deco, G.; Sanz Perl, Y.; Luppi, A.; Gini, S.; Gozzi, A.; Chandaria, S.; Kringelbach, M. L.
10.1101/2025.06.18.660368 — neuroscience — Posted on 2025-06-25
350 Single cell multi-omics reveals rare biosynthetic cell types in the medicinal tree Camptotheca acuminata
Bui, V.-H.; Wood, J. C.; Vaillancourt, B.; Hamilton, J. P.; Carlton, L. H.; Dang, T.-T. T.; Buell, C. R.; Li, C.
10.1101/2025.04.22.650021 — plant biology — Posted on 2025-06-25
351 The titin N2A-MARP signalosome constrains muscle longitudinal hypertrophy in response to stretch
Van der Pijl, R.; Gohlke, J.; Strom, J.; Peters, E.; Shen, S.; Conijn, S.; Hourani, Z.; Lange, S.; Chen, J.; Langlais, P.; Labeit, S.; Granzier, H. L.; Ottenheijm, C.
10.1101/2025.06.19.660595 — physiology — Posted on 2025-06-25
357 Same data, different results? Machine learning approaches in bioacoustics
Wierucka, K.; Murphy, D.; Watson, S. K.; Falk, N.; Fichtel, C.; Leon, J.; Leu, S. T.; Kappeler, P. M.; Briefer, E. F.; Manser, M. B.; Phaniraj, N.; Scheumann, M.; Burkart, J. M.
10.1101/2024.04.14.589403 — animal behavior and cognition — Posted on 2025-06-25
358 Human-specific gene expansions contribute to brain evolution
Soto, D. C.; Uribe-Salazar, J. M.; Kaya, G.; Valdarrago, R.; Sekar, A.; Haghani, N. K.; Hino, K.; La, G. N.; Mariano, N. A. F.; Ingamells, C.; Baraban, A. E.; Jamal, Z.; Turner, T. N.; Green, E. D.; Simo, S.; Quon, G.; Andres, A.; Dennis, M. Y.
10.1101/2024.09.26.615256 — genomics — Posted on 2025-06-25
359 Three Open Questions in Polygenic Score Portability
Wang, J. Y.; Lin, N.; Zietz, M.; Mares, J.; Rathouz, P. J.; Harpak, A.
10.1101/2024.08.20.608703 — genetics — Posted on 2025-06-25
362 Habitat complexity reduces feeding strength of freshwater predators
Aranbarri, M.; Flores, L.; de Guzman, I.; Larranaga, A.; Rall, B. C.; Reiss, J.
10.1101/2025.02.22.639633 — ecology — Posted on 2025-06-25
363 Vocal species are more central in Eastern Himalayan Mixed-Species bird flocks
Gupta, S.; Bharadwaj, A.; Bhat, A.; Thapa, A.; Biswakarma, A.; Tamang, B.; Munda, B.; Biswakarma, B.; Pradhan, D.; Tamang, D.; Rai, M.; Rai, R.; Rai, S.; Srinivasan, U.
10.1101/2024.12.06.626929 — ecology — Posted on 2025-06-25
365 Tissue-specific I-Smad mechanisms revealed by structure-function analysis in Drosophila
Simoncek, A. M.; Sviridoff, S. J.; Hays, J. N.; Graichen, N. N.; Sulkowski, M. J.
10.1101/2025.06.20.660739 — cell biology — Posted on 2025-06-25
366 The second messenger c-di-AMP controls natural competence via ComFB signaling protein
Samir, S.; Doello, S.; Zimmer, E.; Haffner, M.; Enkerlin, A. M.; Mueller, T.; Dengler, L.; Lambidis, S. P.; Sivabalasarma, S.; Albers, S.-V.; Selim, K. A.
10.1101/2023.11.27.568819 — microbiology — Posted on 2025-06-25
371 Attention is all you need (in the brain): semantic contextualization in human hippocampus
Katlowitz, K.; Belanger, J. L.; Ismail, T.; Chavez, A. G.; Chericoni, A.; Franch, M. C.; Mickiewicz, E. A.; Mathura, R. K.; Paulo, D.; Bartoli, E.; Piantadosi, S. T.; Provenza, N. R.; Watrous, A. J.; Sheth, S. A.; Hayden, B. Y.
10.1101/2025.06.23.661103 — neuroscience — Posted on 2025-06-25
373 Central infusion of prostaglandin E2 reveals a unified representation of sickness in the mouse insular cortex
Kamm, G. B.; Boffi, J. C.; Abd El Hay, M.; Rajot, D.; Cukic, A.; Havenith, M.; Scholvinck, M.; Renier, N.; Asari, H.; Prevedel, R.
10.1101/2025.04.28.651028 — neuroscience — Posted on 2025-06-25
374 Phytochemical Screening, Radical Scavenging and Antimicrobial Activities of the Crude Ethanolic, Methanolic, Ethyl Acetate and Chloroform Leaf Extracts of Arayat Pitogo (Cycas riuminiana Porte ex Regel)
Dela Pena, R. A.; Pangilinan, C. R.; Hussain, M. A. S.; Mohamed, M.; Danaphal, A.; Reyes, A.; Banares, A.; Malison, M.; Cayanan, M. M.; Bagunu, J. V.; Totaan, E. V.; Totaan, D.; Gracilla, D. E.
10.1101/2025.06.21.656729 — pharmacology and toxicology — Posted on 2025-06-25
380 Landscape and mutational dynamics of G-quadruplexes in the complete human genome and in haplotypes of diverse ancestry
Chantzi, N.; Liew, S. W.; Wijaya, A.; Chan, C.; Mouratidis, I.; Amaral, E. d. O. S.; Uzun, Y.; Hemberg, M.; Vasquez, K. M.; Kwok, C. K.; Georgakopoulos-Soares, I.
10.1101/2025.06.17.660256 — genomics — Posted on 2025-06-25
382 DNA methylation insulates genic regions from CTCF loops near nuclear speckles
Roseman, S. A.; Siegenfeld, A. P.; Lee, C.; Lue, N. Z.; Waterbury, A. L.; Liau, B. B.
10.1101/2023.07.26.550645 — genomics — Posted on 2025-06-25
383 Variation in response to water availability across Phlox species
Steinecke, C.; Tabin, J. A.; Caven, J.; Hale, C. O.; Serrato-Capuchina, A.; Hopkins, R.
10.1101/2025.06.17.660163 — evolutionary biology — Posted on 2025-06-25
385 Native, Spatiotemporal Profiling of the Global Human Regulome
Pino, L. K.; Canzani, D.; Gutierrez, A.; Robbins, J.; McEllin, B.; Hubbard, E.; Broderick, E.; Prymolenna, A.; Paez, J. S.; Takta, L.; Mercenne, G.; Siebenthall, K.; Fondrie, W. E.; Federation, A. J.
10.1101/2025.06.14.659727 — cell biology — Posted on 2025-06-25
386 Chromatin activity of IκBα mediates the exit from naïve pluripotency
Palma, L. G.; Alvarez-Villanueva, D.; Maqueda, M.; Barrero, M.; IGLESIAS, A.; Bertran, j.; ALVAREZ, D.; GARCIA-PRIETO, C.; BALLARE, C.; RODRIGUEZ-CORTEZ, V.; BUENO, C.; VIDAL, A.; Villanueva, A.; Menendez, P.; Stik, G.; Di Croce, L.; Payer, B.; Esteller, M.; Espinosa, L.; Bigas, A.
10.1101/2023.07.28.550934 — cell biology — Posted on 2025-06-25
387 Microbiome variations in osteoarthritis reflect aging and metabolic factors, not the disease
Bevc, K.; Malfertheiner, L.; Neuenschwander, S.; Tran, V. D. T.; Pagni, M.; Pantiukh, K.; Jagura, M.; Niiranen, T.; Knight, R. T.; Salomaa, V.; Havulinna, A. S.; Org, E.; Eklund, K. K.; Barreto, G.; Zenobi, M.; von Mering, C.
10.1101/2025.06.24.661261 — microbiology — Posted on 2025-06-25
389 High-resolution taxonomic profiling and metatranscriptomics identify microbial, biochemical, host and ecological factors in peri-implant disease
Szafranski, S. P.; Joshi, A. A.; Steglich, M.; Yang, I.; Qu, T.; Behrens, W.; Muthukumarasamy, U.; Melidis, D.; Schaefer-Dreyer, P.; Grischke, J.; Hegermann, J.; Nejdl, W.; Haeussler, S.; Stiesch, M.
10.1101/2025.06.23.661096 — microbiology — Posted on 2025-06-25
392 Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling
Biswas, K.; Moore, C.; Rogers, H.; Wani, K. A.; Higgins, D. P.; Walker, A. K.; Pukkila-Worley, R.; Mullen, G. P.; Rand, J. B.; Francis, M. M.
10.1101/2025.01.06.628021 — neuroscience — Posted on 2025-06-25
394 Mind the Gap: An Embedding Guide to Safely Travel in Sequence Space
Wu, A.; Trolliet, Q.; Rajendran, A.; Lala, J.; Angioletti-Uberti, S.
10.1101/2025.06.19.660524 — synthetic biology — Posted on 2025-06-25
396 Astrocyte CB1 receptors drive blood-brain barrier disruption in CNS inflammatory disease
Colomer, T.; Sanchez-Martin, E.; Bernal-Chico, A.; Moreno-Garcia, A.; Serrat, R.; Baraibar, A. M.; Uribe-Irusta, A.; Iriarte-Sarria, A.; Skupio, U.; Matute, C.; Tepavcevic, V.; Fernandez-Moncada, I.; Chapouly, C.; Marsicano, G.; Mato, S.
10.1101/2025.06.23.660998 — neuroscience — Posted on 2025-06-24
400 Systematic disruption of zebrafish fibrillin genes identifies a translational zebrafish model for Marfan syndrome
De Rycke, K.; Horvat, M.; Caboor, L.; Vermassen, P.; De Smet, G.; Santana Silva, M.; Steyaert, W.; Van Impe, M.; Segers, P.; De Backer, J.; Sips, P. Y.
10.1101/2025.06.21.659830 — genetics — Posted on 2025-06-24
401 A global map for introgressed structural variation and selection in humans
Hsieh, P.; Soisangwan, N.; Gordon, D.; Athef Javidh, A.; Harvey, W.; Porubsky, D.; Hoekzema, K.; Baker, C.; Munson, K.; Kinipi, C.; Leavesley, M.; Brucato, N.; Cox, M.; RICAUT, F.-X.; Gallego Romero, I.; Eichler, E.
10.1101/2025.06.24.661368 — evolutionary biology — Posted on 2025-06-24
404 Clonal memory of cell division in humans diverges between healthy haematopoiesis and acute myeloid leukaemia
Donada, A.; Hermange, G.; Tocci, T.; Midoun, A.; Prevedello, G.; Hadj Abed, L.; Dupre, D.; SUN, W.; Milo, I.; Tenreira Bento, S.; Pospori, C.; Innes, A.; Willekens, C.; Vargaftig, J.; Michonneau, D.; Lo Celso, C.; Servant, N.; Duffy, K.; Isambert, H.; Cournede, P.-H.; Laplane, L.; Perie, L.
10.1101/2025.06.24.660535 — cell biology — Posted on 2025-06-24
405 A genetic screen reveals a key role for Reg1 in 2-deoxyglucose sensing and yeast AMPK inhibition
Ballin, A.; Albanese, V.; Miled, S.; Legros, V.; Chevreux, G.; Verraes, A.; Friedrich, A.; LEON, S.
10.1101/2025.06.23.660305 — cell biology — Posted on 2025-06-24
407 Single Cell Proteomics in the Developing Human Brain
Wu, T.; jiang, l.; Mukhtar, T.; Wang, L.; jian, r.; Wang, C.; Trinh, T.; Kriegstein, A.; Snyder, M.; Li, J.
10.1101/2025.06.23.660079 — neuroscience — Posted on 2025-06-24
409 Maternal singing synchronizes the preterm infants' brain
Benis, D.; Margaria, J.; Barcos-Munoz, F.; Miehlbradt, J.; Lavezzo, L.; Grandjean, D.; Vollenweider, A.; Henriot, S.; Huppi, P. S.; Filippa, M.
10.1101/2025.06.24.660986 — neuroscience — Posted on 2025-06-24
411 Comparative Analysis of Neonatal Hypomyelination Models Using Spatial Transcriptomics
Fabres, R. B.; da Silva, V. R. C. T.; Zhang, S.; Synowiec, S.; Takada, S. H.; Duan, J.; Drobyshevsky, A.
10.1101/2025.06.23.661209 — neuroscience — Posted on 2025-06-24
415 Superficial stromal cell population in the mouse uterus require METTL14 for development and functional competence to support embryo implantation
Zheng, Z.-H.; Jiang, R.-F.; Hong, Y.-Q.; Zhang, Q.-Y.; Deng, Y.-T.; Zhao, J.-Q.; He, J.-P.; Xu, Y.-W.; Yang, S.-H.; Liu, J.-L.
10.1101/2025.06.19.660542 — physiology — Posted on 2025-06-24
416 Model-based Evaluation of Connexin Hemichannel Permeability
Kraujalis, T.; Kersys, L.; Krisciunas, A.; Calneryte, D.; Cicinskaite, A.; Kraujaliene, L.; Verselis, V. K.; Snipas, M.
10.1101/2025.06.19.660562 — biophysics — Posted on 2025-06-24
419 Single-Cell Protein Interactomes by the Proximity Network Assay
Karlsson, F.; Simonetti, M.; Galonska, C.; Karlsson, M. J.; van Ooijen, H.; Kallas, T.; Thiagarajan, D.; Schweitzer, M.; Larsson, L.; van Hoef, V.; Tajvar, P.; Dahlberg, J.; De Temmerman, F.; Leijonancker, L.; Geny, S.; Forlin, R.; Negrini, E.; Petkov, S.; Franzen, L.; Bunz, J.; Moge, C.; Everberg, H.; Brodin, P.; Martinez Barrio, A.; Fredriksson, S.
10.1101/2025.06.19.660329 — bioengineering — Posted on 2025-06-24
422 Giant viruses specific to deep oceans show persistent presence and activity
Liu, W.; Nagasaka, K.; Wu, J.; Ban, H.; Mimick, E.; Meng, L.; Neches, R. Y.; Moniruzzaman, M.; Yoshida, T.; Nishimura, Y.; Endo, H.; Okazaki, Y.; Ogata, H.
10.1101/2025.06.21.660676 — genomics — Posted on 2025-06-24
423 Sedimentary ancient DNA metagenomic analysis provides new insights into farming in central Norway from the Bronze Age to late Medieval period
La Torre, R.; Kosel, P.; Bieker, V. C.; Bakke Westergaard, K.; Lien Mykkeltvedt, J.; Yildirim, K. L.; Seiler, M.; Philippsen, B.; Macphail, R. I.; Cannell, R. J.; Halvorsen, L. S.; Bronseth Lorentzen, A.; Sauvage, R.; Martin, M. D.; Mjelva Breivik, H.; Martin, S. L.
10.1101/2025.06.19.660509 — genomics — Posted on 2025-06-24
424 The eutherian-specific histone H3.4 promotes germ cell development and reproductive fitness
Komarov, P. A.; Bammer, P.; Liang, C.-Y.; Hotz, H.-R.; Fanourgakis, G.; Chun, S.; Kohler, H.; Buchholz, T.-O.; Spetz, J.-F.; Peters, A. H. F. M.
10.1101/2025.06.19.660366 — genetics — Posted on 2025-06-24
425 Targeted sex ratio distortion in the mouse
Bauer, H.; Koch, F.; Lipkowitz, B.; Willert, J.; Blaess, G.; Scholze-Wittler, M.; Waehrisch, S.; Wittler, L.; Herrmann, B.
10.1101/2025.06.19.660540 — genetics — Posted on 2025-06-24
427 A critical role for brain nutrition in the life-history decisions of a partially migratory fish
Koene, J. P.; Jacobs, A.; Zavorka, L.; Pilecky, M.; Honkanen, H.; Kainz, M.; Elmer, K. R.; Adams, C.
10.1101/2025.06.19.660559 — ecology — Posted on 2025-06-24
431 Phylogenomic analysis of the collagen-like BclA proteins in Clostridioides difficile
Cid-Rojas, F.; Guerrero-Araya, E.; Brito-Silva, C.; Pizarro-Guajardo, M.; Rodriguez-Sanchez, C.; Paredes-Sabja, D.
10.1101/2025.06.24.661383 — microbiology — Posted on 2025-06-24
434 Unveiling the hidden biodiversity of microbial chemoreceptor genes in the rare biosphere
Sanchis-Lopez, C.; Santamaria-Hernando, S.; Cantalapiedra, C. P.; Pokorny, L.; Gonzalez-Recio, O.; Sunagawa, S.; Lopez-Solanilla, E.; Huerta-Cepas, J.
10.1101/2025.06.24.661292 — microbiology — Posted on 2025-06-24
435 Integrative microbiome- and metatranscriptome-based analyses reveal diagnostic biomarkers for peri-implantitis
Joshi, A. A.; Szafranski, S. P.; Steglich, M.; Yang, I.; Qu, T.; Xiao, X.; Behrens, W.; Grischke, J.; Haeussler, S.; Stiesch, M.
10.1101/2025.06.24.661241 — microbiology — Posted on 2025-06-24
438 Nutrient landscape shapes the genetic diversification of the human gut commensal Bacteroides thetaiotaomicron
Lang, M.; Zioutis, C.; Heberlein, A.; Ivanovova, N.; Schwarz, J.; Koestlbacher, S.; Bochkareva, O.; Flanagan, K. J.; Pereira, F. C.; Berry, D.
10.1101/2025.06.24.661248 — microbiology — Posted on 2025-06-24
440 Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages a pathway to increased bedaquiline resistance
Fountain, A. J.; Böhning, J.; McLaughlin, S. H.; Morgan, T. E.; Edelstein, P. H.; Troll, M.; Lamers, M. H.; Bharat, T. A. M.; Luisi, B. F.; Ramakrishnan, L.
10.1101/2025.06.24.661325 — microbiology — Posted on 2025-06-24
441 Invasive species drive polymicrobial resistance to amoxicillin in oral biofilms through beta-lactamase release
Seidel, A. L.; Steglich, M.; Qu, T.; Joshi, A. A.; Schneider, M.; Spaic, A.; Yang, I.; Grischke, J.; Rubalskii, E.; Koch, L.; Chichkov, B.; Hegermann, J.; Majewski, P.; Tryniszewska, E.; Slots, J.; Szafranski, S. P.; Stiesch, M.
10.1101/2025.06.24.661089 — microbiology — Posted on 2025-06-24
447 The cost of cognition: Measuring the energy consumption of non-equilibrium computation
Deco, G.; Sanz Perl, Y.; Luppi, A.; Gini, S.; Gozzi, A.; Chandaria, S.; Kringelbach, M. L.
10.1101/2025.06.18.660368 — neuroscience — Posted on 2025-06-24
449 Growth Arrest of Thoracic Aortic Aneurysms in Aging Marfan Mice
Weiss, D.; Means, C.; Mays, G.; Yeung, N.; Cavinato, C.; Manning, E.; Lam, T. T.; Humphrey, J.
10.1101/2025.06.18.660413 — bioengineering — Posted on 2025-06-24
450 Structural connectivity-informed dynamic estimation (STRiDE): Multimodal connectivity constrained ICA
Fouladivanda, M.; Iraji, A.; Wu, L.; Chen, J.; Camazon, P. A.; van Erp, T.; Belger, A.; Pearlson, G. D.; Adali, T.; Calhoun, V.
10.1101/2025.06.18.660402 — bioengineering — Posted on 2025-06-24
452 Survival and reinfection rates of SCTLD-affected corals treated in situ with amoxicillin
Neely, K. L.; Nowicki, R. J.; Dobler, M. A.; Toth, K. A.; Macaulay, K. A.; Gallagher, S. M.
10.1101/2025.06.18.660395 — ecology — Posted on 2025-06-24
457 Botulinum Neurotoxin A1 Signaling in Pain Modulation within Human Sensory Neurons
Gabriel, K.; Hankerd, K.; Barragan Iglesias, P.; Brideau-Andersen, A. D.; Steward, L.; McGaraughty, S.; Vazquez-Cintron, E.; Price, T. J.
10.1101/2025.06.18.660472 — neuroscience — Posted on 2025-06-24
463 Adaptative and ancient co-evolution of integrons with Xanthomonas genomes
Colombi, E.; Ghaly, T. M.; rajabal, v.; Elbourne, L. D. H.; Gillings, M. R.; Tetu, S. G.
10.1101/2025.06.18.660453 — genomics — Posted on 2025-06-24
466 Tiger diet in Ranthambore Tiger Reserve: how do metabarcoding and mechanical sorting compare?
Mishrikotkar, S. K.; Ghosh-Harihar, M.; Yadav, N.; Goswami, V. R.; Harihar, A.; Ramakrishnan, U.
10.1101/2025.06.18.660266 — ecology — Posted on 2025-06-24
468 Modular Inter-brain Synchrony Network Associated with Social Difficulty in Autism Spectrum Disorder: a Graph Neural Network-Driven Hyperscanning Study
Li, Y.; Zhu, Y.; Geng, Y.; Feng, D.; Guan, S.; Li, D.; Zhang, Y.; Mei, L.; Ding, X.; Ying, Y.; Tang, J.; Liang, J.; Su, Y.; Xu, Q.; Li, R.
10.1101/2025.06.18.660087 — neuroscience — Posted on 2025-06-24
469 Predictive modeling of TMS-evoked responses: Unraveling instantaneous excitability states
Ahola, O.; Haxel, L.; Ermolova, M.; Humaidan, D.; Mutanen, T.; Laine, M.; Makkonen, M.; Ukharova, E.; Roine, T.; Lioumis, P.; Guidotti, R.; Ilmoniemi, R.; Ziemann, U.
10.1101/2025.06.18.660274 — neuroscience — Posted on 2025-06-24
470 TNF-α-induced type I IFN signalling decreases neurogenesis and drives T cell chemotaxis
Nissen, T. A. D.; Baig, A.; Rock, D. T.; Shibu, S.; Lee, H.; O'Neill, L. A.; John, S. S.; Klavinskis, L. S.; Thuret, S.
10.1101/2025.06.18.660440 — neuroscience — Posted on 2025-06-24
472 Urological benchtop and in silico models validated by human penile tissue inflation tests
Akbarzadeh Khorshidi, M.; Bose, S.; Watschke, B.; Mareena, E.; Sinnott, T.; Lally, C.
10.1101/2025.06.18.660316 — bioengineering — Posted on 2025-06-24
477 Toward Crosstalk-free All-optical Interrogation of Neural Circuits
YAN, G.; Tian, G.; HE, Y.; SHE, Z.; Chen, K. K. Y.; Semmelhack, J.; Qu, J.
10.1101/2025.06.18.660335 — neuroscience — Posted on 2025-06-24
483 Microenvironmental TGF-β is an early driver of NF1-associated tumour formation
Power, A.; Stierli, S.; Wright, E. H.; Modol-Caballero, G.; Lloyd, E.; Kouloulia, S.; Casal, G.; Krasinska, L.; Bouricha, O.; Venturini, C.; Ribeiro, S.; Napoli, I.; Clements, M.; Parrinello, S.; Lloyd, A. C.
10.1101/2025.06.23.661037 — cell biology — Posted on 2025-06-24
484 α-Synuclein aggregates induce mitochondrial damage and trigger innate immunity to drive neuron-microglia communication
Chakraborty, R.; Maya, S.; Testa, V.; Montero-Munoz, J.; Nonaka, T.; Hasegawa, M.; Consiglio, A.; Zurzolo, C.
10.1101/2025.06.23.661105 — cell biology — Posted on 2025-06-24
485 Single-cell profiling reveals a novel RAB13+ endothelial subpopulation and profibrotic mesenchymal cells in the aged human bone marrow
Cenzano, I.; Cocera, M.; Lopez Perez, A. R.; Campos-Dopazo, L.; Ruiz, J.; Sancho, I.; San Martin-Uriz, P.; Aguirre-Ruiz, P.; Sarvide, S.; Vilas-Zornoza, A.; Ripalda-Cemborain, P.; Alignani, D.; Lopez, A.; Minana Barrios, M.; Quilez Agreda, D.; Ye, J.; Lehmann, R.; Sudupe, L.; Abengozar-Muela, M.; Tamariz-Amador, L.-E.; Muinos-Lopez, E.; Saez, B.; Tegner, J.; A. Calvo, I.; Gomez-Cabrero, D.; Prosper, F.
10.1101/2025.01.28.635238 — molecular biology — Posted on 2025-06-24
486 Increased contact transmission of contemporary Human H5N1 compared to Bovine and Mountain Lion H5N1 in a hamster model
Mukesh, R.; Kaiser, F.; Schulz, J. E.; Gallogly, S.; Prado-Smith, J.; Wickenhagen, A.; Cordove, K.; Smith, B.; Clancy, C.; Shaia, C.; Saturday, G.; de Wit, E.; van Doremalen, N.; Yinda, C. K.; Munster, V.
10.1101/2025.06.23.661180 — microbiology — Posted on 2025-06-24
487 A Chaperonin Complex Regulates Organelle Proteostasis in Malaria Parasites
Tissawak, A.; Rosin, Y.; Katz Galay, S.; Qasem, A.; Shahar, M.; Trabelsi, N.; Schueler-Furman, O.; Johnson, S. M.; Florentin, A.
10.1101/2024.11.13.623364 — microbiology — Posted on 2025-06-24
491 The cytoplasm of living cells can sustain transient and steady intracellular pressure gradients
Malboubi, M.; Esteki, M. H.; Vaghela, M. B.; Korsak, L. I.; Petrie, R. J.; Moeendarbary, E.; Charras, G.
10.1101/2024.04.22.590593 — biophysics — Posted on 2025-06-24
492 A Versatile GPMV-Imaging Platform for Quantitative Analysis of Receptor Binding and Membrane Fusion
Yosibash, I.; Khan, S.; Lichtenstein, A.; Dharan, R.; Vaknin, A.; Daniel, S.; Avinoam, O.; Sorkin, R.
10.1101/2025.05.29.656808 — biophysics — Posted on 2025-06-24
493 Genome-wide rules of transcription factor cooperativity revealed through in silico binding site ablation
He, X.; Einarsson, H.; Palenikova, P.; Rennie, S.; Hu, D.; Cui, R.; Vaagenso, C.; Lage, K.; Krautz, R.; Andersson, R.
10.1101/2025.06.19.660093 — bioinformatics — Posted on 2025-06-24
496 Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma.
Waltner, O. G.; Apfelbaum, A. A.; Wrenn, E. D.; Bhise, S. S.; Kanaan, S. B.; Gladden, R. G.; Mendoza, M. A.; Volden, R.; Kronenberg, Z.; Patel, A.; Dyer, M.; Sarthy, J. F.; Lawlor, E. R.; Furlan, S. N.
10.1101/2025.06.18.660457 — genomics — Posted on 2025-06-24
498 HMMR/RHAMM recruits SACK1D/FAM83D-CK1α complex at the mitotic spindle to control spindle alignment
Sapkota, G. P.; Cartwright, T. N.; Nakarakanti, N. K.; Dunbar, K.; Fulcher, L.; Bader, S.; Wood, N.; Macartney, T.
10.1101/2025.06.23.661043 — cell biology — Posted on 2025-06-24
500 Exosomes are specialized vehicles to induce fibronectin assembly
Sung, B. H.; Emmanuel, M.; Gari, M.; Guerrero, J.; Virumbrales-Munoz, M.; Inman, D.; Krystofiak, E.; Rapraeger, A. C.; Ponik, S. M.; Weaver, A.
10.1101/2025.06.23.661091 — cell biology — Posted on 2025-06-24
501 Natural Product-Like Fragments Unlock Novel Chemotypes for a Kinase Target - Exploring Options beyond the Flatland
Santura, A.; Mueller, J.; Wolter, M.; Tutzschky, I.-C.; Ruf, M.; Metz, A.; Sandner, A.; Merkl, S.; Klebe, G.; Glinca, S.; Czodrowski, P.
10.1101/2025.06.11.659015 — molecular biology — Posted on 2025-06-24
506 Development of PROTACs for targeted degradation of oncogenic TRK fusions
Kumar, S.; Jiang, J.; Donald-Paladino, M. S.; Chen, J.; Gutierrez, A.; Federation, A. J.; Szulzewsky, F.; Holland, E. C.; Ferguson, F. M.; Nabet, B.
10.1101/2025.06.18.660465 — cancer biology — Posted on 2025-06-24
509 Fluidic Programmable Gravi-maze Array for High Throughput Multiorgan Drug Testing
Wong, H. C.; Collins, C. J.; Jude Jose, J. A.; Bhakta, I. N.; Collins, A. J.; Katara, G.; Kohana, J.; Saluja, H. S.; Collins, J.
10.1101/2025.06.18.660241 — bioengineering — Posted on 2025-06-24
512 Pre-meiotic H1.1 degradation is essential for Arabidopsis gametogenesis
Li, Y.; Fei, D.; Schubert, J.; Rutowicz, K.; Kaczmarska, Z.; Linares, A.; Giraldo-Fonseca, A.; Bischof, S.; Grossniklaus, U.; Baroux, C.
10.1101/2025.04.18.649492 — plant biology — Posted on 2025-06-24
513 Sexual reproduction is controlled by successive transcriptomic waves in Podospora anserina
Bidard, F.; Grognet, P.; Lelandais, G.; Imbeaud, S.; Mucchielli-Giorgi, M. H.; Debuchy, R.; Berteaux-Lecellier, V.; Malagnac, F.
10.1101/2024.12.09.627484 — genomics — Posted on 2025-06-24
514 A Chemostat-Based Model for Growing Bacterial Biofilms
Spagnolo, F.; Caballero, I.; Goldblatt, A.; Loccisano, M. J.; Mahe, M. I.; Mejia, Y.; Melvani, N.; Nagel, A.; Stanciu, A.; Kannoly, S.; Dennehy, J. J.; Trujillo, M.
10.1101/2025.06.22.660958 — microbiology — Posted on 2025-06-24
516 Chronological lifespan extension and nucleotide salvage inhibition in yeast by isonicotinamide supplementation
Kalita, A.; Letai, C. T.; Hesles, E. E.; Power, L. N.; Mishra, S.; Saha, S.; Dinda, M.; Wang, D.; Singh, P. K.; Smith, J. S.
10.1101/2021.07.11.451986 — biochemistry — Posted on 2025-06-24
521 The evolutionary history of plastid outer envelope proteins - a structure-sequence comparison
Bueyuektas, D.; Mehl, J. A.; Engelsdorf, T.; Voll, L. M.; Kunz, H.-H.; Schwenkert, S.; de Vries, S.
10.1101/2025.06.18.660430 — evolutionary biology — Posted on 2025-06-24
522 Rapid detection of G6PD deficiency SNPs using a novel amplicon-based MinION Sequencing Assay
Tacoli, C.; Kleinecke, M.; Soon Hoon, K.; Trimarsanto, H.; Nadeem, M.; Eam, R.; Khim, N.; Rumaseb, A.; Ley, B.; Sayre, D.; Phok, S.; Lek, D.; Witkowski, B.; Hwang, J.; Auburn, S.; Mueller, I.; Price, R.; Popovici, J.
10.1101/2025.06.23.661218 — microbiology — Posted on 2025-06-24
526 Common Gene Networks Orchestrate Organelle Architecture and Inter-Organelle Metabolic Flows for Mucin Production in High Endothelial and Goblet Cells
Bi, Y.; Brulois, K. F.; Ayesha, A.; Xiang, M.; Ballet, R.; Ocon, B.; Dinh, T.; Wang, Y.; Lazarus, N.; Kunte, M.; Ramos, G.; Bao, E.; Lupu, F.; Lin, J. H.; Butcher, E.; Pan, J.
10.1101/2025.06.19.660616 — immunology — Posted on 2025-06-24
527 Phytochemical Screening, Radical Scavenging and Antimicrobial Activities of the Crude Ethanolic, Methanolic, Ethyl Acetate and Chloroform Leaf Extracts of Arayat Pitogo (Cycas riuminiana Porte ex Regel)
Gracilla, D. E.; Dela Pena, R. A.; Pangilinan, C. R.; Hussain, M. A. S.; Mohamed, M.; Danaphal, A.; Reyes, A.; Banares, A.; Malison, M.; Cayanan, M. M.; Bagunu, J. V.; Totaan, E. V.; Totaan, D.
10.1101/2025.06.21.656729 — plant biology — Posted on 2025-06-24
528 Seasonal changes in the physiology and metabolism of grapevine perennating buds
Signorelli, S.; Hermawaty, D.; Feil, R.; Couture, C.; Lunn, J. E.; Considine, J. E.; Considine, M. J.
10.1101/2025.06.17.660214 — plant biology — Posted on 2025-06-24
529 MdBRC1 and MdFT2 Interaction Fine-Tunes Bud Break Regulation in Apple
Gioppato, H. A.; Estevan, J.; Al Bolbol, M.; Soriano, A.; Garighan, J.; Jeong, K.; Georget, C.; Soto, D. G.; El Khoury, S.; Falavigna, V. d. S.; George, S.; Perales, M.; Andres, F.
10.1101/2025.06.20.660803 — plant biology — Posted on 2025-06-24
531 Cell layer-specific modification of cell wall is associated with exo-mesocarp split in pistachio (Pistacia vera L.)
Zhang, S.; Wang, M.; Eagle, S.; Chernikova, A.; Bedell, K. M.; Tran, P.; Lee, C.; Adaskaveg, J. A.; Wei, Y.; Lopez, R.; Basco, A.; Gordon, P.; Blanco-Ulate, B.; Monroe, G.; Drakakaki, G.
10.1101/2025.06.18.660460 — plant biology — Posted on 2025-06-24
532 LIKE EARLY STARVATION is involved in the regulation of starch initiation in potato (Solanum tuberosum cv. Desiree) tubers
Locquet, C.; Berti, M.; Bray, F.; Hulin, H.; Stoclet, G.; Seung, D.; Lourdin, D.; D'Hulst, C.; Wattebled, F.; Szydlowski, N.
10.1101/2025.06.23.661224 — plant biology — Posted on 2025-06-24
535 PanVA: a visual analytics tool for pangenomic variant analysis
van den Brandt, A.; de Vries, F.; van Esch, R.; Vlugter, S.; van Workum, D.-J. M.; van de Wetering, H.; Vilanova, A.; Smit, S.
10.1101/2025.06.23.661080 — bioinformatics — Posted on 2025-06-24
537 An atlas of cell type specific regulatory effects in cattle
Li, H.; Zhang, H.; Zhao, P.; Zhang, Q.; Zhu, S.; Shi, T.; Wang, Y.-N.; Lu, J.-S.; Yang, L.; O'Grady, J. F.; MacHugh, D. E.; Wang, Y.; Wei, Z.; Lv, X.; Wang, M.-S.; Han, B.; Zheng, W.; Chen, A.; Akter, S.; Bhowmik, N.; Ma, Y.; Baldwin VI, R. L.; Li, C.; Jiang, J.; Ma, L.; Maltecca, C.; Wang, J.; Gong, M.; Zhu, X.; Lin, Q.; Xi, Y.; Zhu, D.; Teng, J.; GUAN, D.; An, B.; Ren, J.; Hou, Y.; Wang, F.; Li, B.; Frantz, L.; Larson, G.; Cai, Z.; Sahana, G.; Jiang, Y.; Sun, H.; Sun, D.; Liu, G. E.; Fang, L.
10.1101/2025.06.23.661035 — genetics — Posted on 2025-06-24
539 Transposable elements hitchhike on Starships across fungal genomes
Griem-Krey, H.; de Fraga SantAna, J.; Oggenfuss, U.; Calegari-Alves, Y. P.; Marques, A. L.; Berger, M.; Santi, L.; Beys-da-Silva, W. O.; Habig, M.
10.1101/2025.06.18.660325 — evolutionary biology — Posted on 2025-06-24
542 Nanoparticle-Supported, Rapid, and Electronic Detection of SARS-CoV-2 Antibodies and Antigens at Sub-Femtomolar Level
Choi, Y.; Mirjalili, S.; Ikbal, M. A.; McClure, S.; Kalatehmohammadi, M.; Clemens, S.; Solano, J.; Heggland, J.; Zhang, T.; Zuo, J.; Wang, C.
10.1101/2024.09.04.611305 — microbiology — Posted on 2025-06-24
545 TWEAK Signaling Drives the Transition from Psoriasis to Atopic Dermatitis-like Inflammation in Paradoxical Skin Reactions
Marella, S.; Bogle, R.; Zhang, H.; Fox, J.; Kirma, J.; Xing, X.; Klein, B.; van Drongelen, V.; Feister, Z.; Zagairy, F.; Hamed, M.; Jiang, R.; Dey, P.; Kahlenberg, J. M.; Billi, A. C.; Tsoi, L. C.; Gudjonsson, J.; Cohen Barak, E.
10.1101/2025.06.19.660481 — immunology — Posted on 2025-06-24
546 Attention is all you need (in the brain): semantic contextualization in human hippocampus
Katlowitz, K.; Belanger, J. L.; Ismail, T.; Chavez, A. G.; Chericoni, A.; Franch, M. C.; Mickiewicz, E. A.; Mathura, R. K.; Paulo, D.; Bartoli, E.; Piantadosi, S. T.; Provenza, N. R.; Watrous, A. J.; Sheth, S. A.; Hayden, B. Y.
10.1101/2025.06.23.661103 — neuroscience — Posted on 2025-06-24
550 Thriving Across Depths: How Blue Light Shapes a Large PSI Supercomplex and Specic Photosynthetic Traits in the seagrass Posidonia oceanica.
Charras Ferroussier, Q.; Mathiot, C.; Semchonok, D. A.; Elias, E.; Bhatti, A. F.; Lebrun, R.; Guillemain, D.; Siponen, M.; Croce, R.; Jungas, C.
10.1101/2025.06.20.660723 — plant biology — Posted on 2025-06-24
552 Optimizing population simulations to accurately parallel empirical data for digital breeding
Burns, M. J.; Della Coletta, R.; Fernandes, S. B.; Bohn, M. O.; Lipka, A. E.; Hirsch, C. N.
10.1101/2025.06.18.660215 — plant biology — Posted on 2025-06-24
554 Persistent chromatin alterations and gene expression reprogramming follow widespread DNA damage in glioblastoma
Modrek, A. S.; Chandradoss, K. R.; Do, C.; Ezhilarasan, R.; Sakellaropoulos, T.; Karp, J.; Ding, Y.; Zhang, Z.-Y.; Graciani, M.; Cova, G.; Phillips-Cremins, J. E.; Sulman, E. P.; Skok, J. A.
10.1101/2025.06.18.660431 — genomics — Posted on 2025-06-24
557 Longevity in plants impacts phylogenetic and population dynamics
Smith, S. A.; Pease, J. B.; Carruthers, T.; Bradburd, G. S.; Huegele, I. B.; Stull, G. W.; Weaver, W. N.; Yang, Y.; Yi, T.-S.; Beaulieu, J. M.
10.1101/2025.06.20.660758 — evolutionary biology — Posted on 2025-06-24
560 Arctic defaunation initiated a cascade of mammal-plant interaction shift through dispersal dynamics
Liu, S.; Stoof-Leichsenring, K. R.; Hütt, M.-T.; Biskaborn, B.; Diekmann, B.; Kaufman, D. S.; Meyer, H.; Melles, M.; Pestryakova, L. A.; Herzschuh, U.
10.1101/2025.06.23.661215 — ecology — Posted on 2025-06-24
561 Host-specific fungal plant pathogens exhibit distinct interactions with the leaf microbiota of wild grasses
Flores-Nunez, V. M.; Dal'Sasso, T. C. S.; Hansen, M.; Reinhardt, G.; Braun, S.; Stukenbrock, E. H.
10.1101/2025.06.24.661283 — microbiology — Posted on 2025-06-24
567 Developmental Plasticity and Stromal Co-option Shape a Pituitary Neuroendocrine Tumor Transcriptional Continuum
Osorio, R. C.; Oh, J. Y.; Jung, J.; Ehrenberg, A. J.; Saha, A.; Lad, M.; Khela, H.; Brennick, N.; Giannikopoulos, P.; Seeley, W. W.; Grinberg, L. T.; Diaz, A.; Aghi, M. K.
10.1101/2025.06.18.659743 — cancer biology — Posted on 2025-06-24
568 Soluble E-cadherin Drives Brain Metastasis in Inflammatory Breast Cancer
hu, x.; Xiong, Y.; Villodre, E. S.; zhang, H.; Song, J.; Fowlkes, N.; Krishnamurthy, S.; Rylander, M. N.; Bartholomeusz, C.; Tripathy, D.; The MDACC Inflammatory Breast Cancer Team, ; Woodward, W.; Chen, J.; Debeb, B. G.
10.1101/2025.06.18.660428 — cancer biology — Posted on 2025-06-24
570 MEM-GAN: A Pseudo Membrane Generator for Single-cell Imaging in Fluorescent Microscopy
Wang, Y.; Ding, J.; Wu, L.; Wardhani, A.; Danaher, P.; Wen, H.; Tang, W.; Lu, Q.; Chang, Y.; Lei, Y. L.; Tang, J.; Xie, Y.
10.1101/2023.11.08.566343 — bioinformatics — Posted on 2025-06-24
571 Perfusable 3D models of ureteric bud and collecting duct tubules
Wolf, K. J.; van Gaal, R. C.; Uzel, S. G. M.; Rubins, J. E.; Klaus, A. N.; Printz, A.; Nair, P.; Kroll, K. T.; Stankey, P.; Satlin, L. M.; Lewis, J. A.
10.1101/2025.06.19.659798 — bioengineering — Posted on 2025-06-24
579 Aberrant brain-type neuronal programs in large-cell pancreatic neuroendocrine carcinoma
Debnath, O.; Berger, H.; Detjen, K.; Kirchner, P.; Marinoni, I.; Eichhorn, I.; Bolduan, F.; Conrad, T.; Horst, D.; Eils, R.; Wiedenmann, B.; Perren, A.; Ishaque, N.
10.1101/2025.06.18.660360 — cancer biology — Posted on 2025-06-24
580 Integrated genetic screening reveals FEN1 as a driver of stemness and temozolomide resistance in glioblastoma
Brakel, B. A.; McKenna, D.; Puri, A.; Shaikh, V. M.; Singh, M.; Saleh, A.; Tomajian, A.-j.; Mikolajewicz, N.; Beltrami, M.; Anand, A.; Miletic, P.; Brown, K. R.; Tieu, D.; Maich, W.; Salim, S.; Suk, Y.; Subapanditha, M.; Gendoo, D. M. A.; Venugopal, C.; Moffat, J.; Katyal, S.; Chokshi, C. R.; Singh, S. K.
10.1101/2025.06.18.660339 — cancer biology — Posted on 2025-06-24
581 GOLF: A Generative AI Framework for Pathogenicity Prediction of Myocilin OLF Variants
Walton, T. A.; Tsui, D.; Fogel, L.; Huard, D.; Chagas, R.; Lieberman, R. L.; Aghazadeh, A.
10.1101/2025.06.17.660210 — bioinformatics — Posted on 2025-06-24
582 A Tunable Pulmonary Organoid Model Demonstrates Compositionally Driven Epithelial Plasticity and Immune Polarization
Edelstein, S. E.; Mizoguchi, S.; Gracia, M. T.; Wang, N.; Lee, V.; Kim, H.; Haynes, C.; Danelski, C.; Tsuchiya, T.; Sauler, M.; Raredon, M. S. B.
10.1101/2025.06.05.658120 — bioengineering — Posted on 2025-06-24
584 daf-16/FOXO promotes the activity of ligand-bound DAF-12/NHR to coordinate dauer recovery and post-dauer seam cell fate
Wirick, M. J.; Smith, I. T.; Olson, B. S.; Alessi, A. F.; Galagali, H.; Lalk, K.; Schmidt, M. N.; Ranke, K. J.; Kim, J. K.; Karp, X.
10.1101/2025.06.18.660181 — developmental biology — Posted on 2025-06-24
585 Cis-aconitate therapy protects against influenza mortality by dual targeting of viral polymerase and ERK/AKT/NF-κB signaling
Cezard, A.; Diakite, D.; Vasseur, V.; Wacquiez, A.; Gonzalez, L.; Le Goffic, R.; Da Costa, B.; FOUQUENET, D.; Heumel, S.; Machelart, A.; Hoffmann, E.; Brodin, P.; Trottein, F.; Mathieu, C.; Canus, L.; Jacolin, F.; Vidalain, P.-O.; Perrin-Cocon, L.; Lotteau, V.; Tertigas, D.; Burlaud-Gaillard, J.; Surette, M. G.; Legras, A.; Sizaret, D.; Baranek, T.; Paget, C.; Guillon, A.; Si-Tahar, M.
10.1101/2025.06.18.660279 — immunology — Posted on 2025-06-24
586 A Multigenerational ''Dirty'' Mouse Model for Studying Trauma-Induced Immune Dysregulation and Infection Susceptibility
Byskosh, A.; Pulford, J.; Murzin, E.; Michael, Z.; Lovell, C. G.; Niu, B.; Seshadri, A.; Brat, G.; Zajdel, A.; Borriello, F.; Lederer, J.
10.1101/2025.06.18.660185 — immunology — Posted on 2025-06-24
587 Oxytocin neurons signal state-dependent transitions from rest to thermogenesis and behavioral arousal in social and non-social settings
Vandendoren, M.; Landen, J. G.; Rogers, J. F.; Killmer, S.; Alimiri, B.; Pohlman, C.; Tattersall, G. J.; Bedford, N. L.; Nelson, A. C.
10.1101/2024.10.22.619715 — neuroscience — Posted on 2025-06-24
588 Ablation of hematopoietic stem cell derived adipocytes reduces tumor burden in syngeneic mouse models of high-grade serous carcinoma
Woodruff, E. R.; Bailey, C. A.; To, F.; Manda, V.; Maltzahn, J. K.; Sullivan, T. M.; Boorgula, M. P.; Recouvreux, M. S.; Vianzon, R.; Conrad, B.; Gavin, K. M.; Jordan, K. R.; Klemm, D. J.; Orsulic, S.; Bitler, B. G.; Watson, Z. L.
10.1101/2024.09.19.613924 — cancer biology — Posted on 2025-06-24
589 Towards site-specific information on PET degrading enzymesusing NMR near operational temperature
Gabrielli, V.; Grga, J.; Gavalda, S.; Perrot, L.; Cantrelle, F.-X.; Boll, E.; Lippens, G.; Charlier, C.
10.1101/2024.09.10.612188 — biophysics — Posted on 2025-06-24
591 Inhalable Perfluorocarbon RNA Nanocapsules Bypass Immune Clearance While Targeting Lung Epithelial and Lung Tumor Cells
Siddhanta, K.; Monirvaghef, A.; Sundar, A.; Pinkerton, B. R.; Kumari, N.; Ding, L.; Woslager, C. J.; Kalpana, M. A.; Jogdeo, C. M.; Ravnholdt, A. R.; Poole, J. A.; Santarpia, J.; Talmadge, J. E.; Oupicky, D.
10.1101/2025.06.05.658088 — bioengineering — Posted on 2025-06-24
592 Septin7 is essential in early hematopoiesis, but redundant at later stages
Ronkina, N.; Verheyden, N.; Gambhir, P.; Laass, K.; Yakovleva, T.; Doerrie, A.; Abbey, M.; Menon, M. B.; Selich, A.; Galla, M.; Rothe, M.; Schambach, A.; Krueger, A.; Kotlyarov, A.; Gaestel, M.
10.1101/2025.04.22.649981 — biochemistry — Posted on 2025-06-24
594 PERADIGM: Phenotype Embedding Similarity-based Rare Disease Gene Mapping
Zheng, W.; Xie, Y.; Gu, J.; Li, H.; Somlo, S.; Besse, W.; Zhao, H.
10.1101/2025.04.01.646670 — genetics — Posted on 2025-06-24
595 L-2-hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression
Gu, W.; Wang, X.; Solmonson, A.; Cai, L.; Xiao, Y.; Tasdogan, A.; Franklin, J.; Zhang, Y.; Zhang, H.; Westfall, A. K.; Rowe, A.; Trivedi, H.; Faubert, B.; Wu, Z.; Sudderth, J.; Zacharias, L. G.; Afroze, B.; Bezprozvanny, I.; Sudarshan, S.; Cai, F.; McBrayer, S. K.; Mathews, T. P.; DeBerardinis, R. J.
10.1101/2025.04.16.649033 — genetics — Posted on 2025-06-24
596 Measuring the Strength of Spatial Sorting
Goel, N.; Comerford, M. S.; Bernat, A.; Egan, S. P.; Juenger, T. E.; Keitt, T. H.
10.1101/2025.01.17.633577 — evolutionary biology — Posted on 2025-06-24
602 Vocal species are more central in Eastern Himalayan Mixed-Species bird flocks
Gupta, S.; Bharadwaj, A.; Bhat, A.; Thapa, A.; Biswakarma, A.; Tamang, B.; Munda, B.; Biswakarma, B.; Pradhan, D.; Tamang, D.; Rai, M.; Rai, R.; Rai, S.; Srinivasan, U.
10.1101/2024.12.06.626929 — ecology — Posted on 2025-06-24
604 Natural Product-Like Fragments Unlock Novel Chemotypes for a Kinase Target - Exploring Options beyond the Flatland
Santura, A.; Mueller, J.; Wolter, M.; Tutzschky, I.-C.; Ruf, M.; Metz, A.; Sandner, A.; Merkl, S.; Klebe, G.; Glinca, S.; Czodrowski, P.
10.1101/2025.06.11.659015 — molecular biology — Posted on 2025-06-24
605 A Cas12a Toolbox for Rapid and Flexible Group B Streptococcus Genomic Editing and CRISPRi
Hillebrand, G. H.; Carlin, S. M.; Giacobe, E. J.; Stephenson, H. A.; Collins, J.; Hooven, T. A.
10.1101/2025.06.20.660720 — microbiology — Posted on 2025-06-24
606 IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion
Aldridge, D. L.; Lanzar, Z.; Phan, A.; Christian, D. A.; Pardy, R.; Min, B.; Kedl, R.; Hunter, C. A.
10.1101/2025.01.15.633135 — immunology — Posted on 2025-06-24
607 MLL1 directs gut-associated antibody responses to helminth and bacterial infections
Zhang, Y.; Chakma, C.; Kirn, A.; Chisanga, D.; Polmear, J.; Zaini, A.; Farighi, R.; Xie, L.; Lopez-Urena, D.; Mileto, S.; Lyras, D.; Zaph, C.; Groom, J. R.; Good-Jacobson, K.
10.1101/2024.08.21.609083 — immunology — Posted on 2025-06-24
608 Assessing the degree of cortical dislamination through electrical pattern analysis
Aquiles, A.; Pinedo-Vargas, L.; Luna-Munguia, H.; Pena-Ortega, F.; Concha, L.; Rossi-Pool, R.
10.1101/2025.06.16.659942 — neuroscience — Posted on 2025-06-24
610 Cognitive reserve linked to network-specificbrain-ventricle coupling modes
Campo, F. F.; Brattico, E.; Miguel, V.; Magalhaes, V.; Nigro, S.; Tafuri, B.; Logroscino, G.; Cabral, J.; the Alzheimer's Disease Neuroimaging Initiative,
10.1101/2025.01.04.631289 — neuroscience — Posted on 2025-06-24
611 Correlations of neural predictability and information transfer in cortex and their relation to predictive coding
Fiorenza, J. P.; Le Donne, L.; Schmidt-Samoa, C.; Heide, E.- C.; von der Brelie, C.; Malinova, V.; Focke, N. K.; Wilke, M.; Melloni, L.; Schwiedrzik, C. M.; Wibral, M.
10.1101/2025.05.23.655705 — neuroscience — Posted on 2025-06-24
614 Cultivar mixtures stabilize wheat baking quality rather than improve it
Stefan, L.; Strebel, S.; Camp, K.-H.; Christinat, S.; Fossati, D.; Stadeli, C.; Levy Haener, L.
10.1101/2025.06.20.660693 — plant biology — Posted on 2025-06-24
616 Associations of genetic and spectral diversity in European beech
Czyz, E. A.; Schmid, B.; Eppinga, M. B.; de La Harpe, M.; Moradi, A.; Li, C.; Coq--Etchegaray, D.; Schaepman, M. E.; Schuman, M. C.
10.1101/2023.08.16.553487 — plant biology — Posted on 2025-06-24
617 Serotypes of Dengue Virus and Kdr Mutations F1534C, S989P, V410L, V1016I, and V1016G in Aedes aegypti and Aedes albopictus Mosquitoes from the commune of AbomeyCalavi, Southern Benin
Tokponnon, F. T.; AMOUSSA, O. D. A.; Dabou, Z. S.; Kpemasse, N.; Ahouandjinou, M. J.; Towakinou, L.; Agassounon, B.; Tandjekpon, O. S.; Gandaho, F. C.; Issa, M.; Gounou Yerima, I.; Houessinon, F.; Dougnon, V.; Oxborough, R. M.; Mesenger, L.; Osse, R.; Baba-Moussa, L.; KINDE-GAZARD, D.; Akogbeto, M.
10.1101/2025.06.20.660662 — biochemistry — Posted on 2025-06-24
618 Epitope Effect Prevalence in Affinity-based pQTL studies
Kuliesius, J.; Badonyi, M.; Navarro, P.; Marsh, J. A.; Klaric, L.; Wilson, J. F.
10.1101/2025.06.20.660695 — genomics — Posted on 2025-06-24
622 Evaluating the utility of amino acid similarity-aware kmers to represent TCR repertoires for classification
Kockelbergh, H.; Evans, S. C.; Brierley, L.; Green, P. L.; Jorgensen, A. L.; Soilleux, E. J.; Fowler, A.
10.1101/2024.12.06.626025 — immunology — Posted on 2025-06-24
623 An end-to-end framework for Cell DIVE multiplexed imaging and spatial immune microenvironment analysis
Bhalla, A.; Mackerodt, J.; Pohin, M.; Hill, S.; Richard, J.-B.; Thomas, T.; Henninger, R.; Ginty, F.; Corwin, A.; McDonough, E.; Surrette, C.; Midwood, K. S.; Korsunsky, I.; Buckley, C. D.; Windell, D.; Coles, M. C.
10.1101/2025.06.20.656440 — immunology — Posted on 2025-06-24
624 Pathogenic strains of a gut commensal drive systemic platelet activation and thromboinflammation in lupus nephritis
Amarnani, A.; Rivera, C. F.; Cornwell, M.; Weinstein, T.; Gottesman, S.; Loomis, C.; Azad, Z.; Lee, A.; Prasad, J.; Barnes, B. J.; Yi, M.; Ullah, N.; Gisch, N.; Ruggles, K.; Ramkhelawon, B.; Silverman, G. J.
10.1101/2025.06.20.641288 — immunology — Posted on 2025-06-24
625 Structural Determinants of Signal Speed: A Multimodal Investigation of Face Processing in Autism Spectrum Disorder
Coleman, C. R.; Nance, M. G.; Jacokes, Z.; Druzgal, T. J.; Arutiunian, V.; Kresse, A.; Sullivan, C. A. W.; Santhosh, M.; Neuhaus, E.; Borland, H.; Bernier, R. A.; Bookheimer, S. Y.; Dapretto, M.; Jack, A.; Kleinhans, N. M.; Jeste, S.; McPartland, J. C.; Naples, A.; Geschwind, D.; Gupta, A. R.; Webb, S. J.; Pelphrey, K. A.; Van Horn, J. D.; Newman, B. T.; Puglia, M. H.; on behalf of the ACE GENDAAR Consortium,
10.1101/2025.03.19.644214 — neuroscience — Posted on 2025-06-24
627 High-resolution whole-brain magnetic resonance spectroscopic imaging in youth at risk for psychosis
Celereau, E.; Lucchetti, F.; Aleman-Gomez, Y.; Dwir, D.; Cleusix, M.; Ledoux, J.-B.; Jenni, R.; Bach Cuadra, M.; Schilliger, Z.; Solida, A.; Armando, M.; Plessen, K. J.; Hagmann, P.; Conus, P.; Klauser, A.; Klauser, P.
10.1101/2025.06.22.660965 — neuroscience — Posted on 2025-06-24
629 In vivo CRISPR screening identifies NF1/RASA1/TP53 co-mutations and downstream MEK signaling as a common key mechanism of sinonasal tumorigenesis
Vu, K. P.; Gunti, S.; Viswanathan, R.; Nandal, A.; Larkin, R.; Cho, S.; Zou, J.; Ramolia, S.; Hoke, A. T. K.; Barbosa, S. M.; Gallia, G. L.; Rooper, L. M.; Floudas, C. S.; Cheng, H.; Miller, C. N.; Guest, M. R.; Notaro, M.; Raziuddin, A.; Sun, Z.; Wu, X.; Faraji, F.; Lechner, M.; Comoglio, F.; Edmondson, E. F.; Chari, R.; London, N. R.
10.1101/2025.05.19.654661 — cancer biology — Posted on 2025-06-24
630 Spatial determinants of tumor cell dedifferentiation and plasticity in primary cutaneous melanoma
Vallius, T.; Shi, Y.; Novikov, E.; Pant, S. M.; Pelletier, R.; Chen, Y.-A.; Tefft, J. B.; Nirmal, A. J.; Maliga, Z.; Wan, G.; Murphy, G.; Santagata, S.; Semenov, Y.; Liu, D.; Lian, C. G.; Sorger, P. K.
10.1101/2025.06.21.660851 — cancer biology — Posted on 2025-06-24
631 Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics
Avraham-Davidi, I.; Mages, S.; Klughammer, J.; Moriel, N.; Imada, S.; Hofree, M.; Murray, E.; Chen, J.; Pelka, K.; Mehta, A.; Boland, G. M.; Delorey, T. M.; Caplan, L.; Dionne, D.; Strasser, R.; Lalakova, J.; Niesnerova, A.; Xu, H.; Rouault, M.; Tirosh, I.; Hacohen, N.; Chen, F.; Yilmaz, O. H.; Roper, J.; Rozenblatt-Rosen, O.; Nitzan, M.; Regev, A.
10.1101/2022.10.02.508492 — cancer biology — Posted on 2025-06-24
637 Predicting Brain Volumes from Anthropometric and Demographic Features: Insights from UK Biobank Neuroimaging Data
Nazarzadeh, K.; Eickhoff, S. B.; Antonopoulos, G.; Hensel, L.; Tscherpel, C.; Komeyer, V.; Raimondo, F.; Grefkes, C.; Patil, K. R.
10.1101/2025.06.22.660902 — neuroscience — Posted on 2025-06-23
638 Bifidobacterium longum subsp. nexus nov., a novel subspecies isolated from infant stool
Ennis, D.; Andreu-Sanchez, S.; Levin, Y.; Goldberger, O.; Mallon, C. A.; Jayaprakash, Y. K.; Shao, Y.; Zhao, S.; Sinha, T.; Fu, J.; Weersma, R. K.; Alm, E.; Amster-Choder, O.; Lawley, T. D.; Harmsen, H. J. M.; van Sinderen, D.; Zhernakova, A.; Yassour, M.
10.1101/2025.06.23.661074 — microbiology — Posted on 2025-06-23
639 GENETIC, MORPHOLOGICAL, AND PHYTOCHEMICAL DIFFERENTIATION OF CARNAVAL - A NEW HOP CULTIVAR ADAPTED TO TROPICAL ENVIRONMENT
Lima, R. B. d. S.; Delgado, C. H. O.; Raffaele, M. V.; Croce, V. P.; Pinheiro, J. B.; Marques, M. O. M.; Marroquin, J. A. M.; Martin, G. A. d. S.; Oliveira, F. R.; Silva, L. T. P.; Mondin, M.
10.1101/2025.06.17.660195 — plant biology — Posted on 2025-06-23
640 Human Saphenous Vein Ex Vivo Culture as a Translational Model of Intimal Hyperplasia
Zhao, S.; Deslarzes, C.; Urfer, S.; Thevenet, J.; Bechelli, C.; Lambelet, M.; Allagnat, F.; Deglise, S.
10.1101/2025.06.17.660253 — physiology — Posted on 2025-06-23
642 A translatable evaluation tool to study the biodistribution of clinically-available doxorubicin liposomes: PET imaging of Zr-Talidox
Carrascal-Minino, A.; Mishra, A.; Gawne, P.; Angoh, S.; Chupin, J.; Kim, J.; de Santis, V.; Pham, T.; Bark, F.; Khan, A.; Long, N. J.; T. M. de Rosales, R.
10.1101/2025.06.17.660144 — bioengineering — Posted on 2025-06-23
644 The Mycobacterium smegmatis bd-II terminal oxidase employs a 1 carboxylate shift mechanism
Kovalova, T.; Janczak, M.; Gamiz-Hernandez, A. P.; Lundin, D.; Sharma, S.; Vilhjalmsdottir, J.; Sjoestrand, D.; Kaila, V. R. I.; Hoegbom, M.; Aedelroth, P.
10.1101/2025.06.23.660515 — biochemistry — Posted on 2025-06-23
648 Transcriptional Elongation-Associated RNA Processing Errors in Induced Cellular Growth Arrest
Parast, S.; Wang, S.; Iwanaszko, M.; He, Y.; Olgun, D. G.; Gold, S. R.; Aoi, Y.; Zeidner, J. M.; Howard, B. C.; Thakur, W. R.; Ramani, V.; Shilatifard, A.
10.1101/2025.06.23.660200 — molecular biology — Posted on 2025-06-23
649 Increased contact transmission of contemporary Human H5N1 compared to Bovine and Mountain Lion H5N1 in a hamster model
Mukesh, R.; Kaiser, F.; Schulz, J. E.; Gallogly, S.; Prado-Smith, J.; Wickenhagen, A.; Cordove, K.; Smith, B.; Clancy, C.; Shaia, C.; Saturday, G.; de Wit, E.; van Doremalen, N.; Yinda, C. K.; Munster, V.
10.1101/2025.06.23.661180 — microbiology — Posted on 2025-06-23
651 Tre-DST: A new drug susceptibility test for Mycobacterium tuberculosis using solvatochromic trehalose probes
Schwartz, L. A.; Brodeth, A. L.; Susilo, C. T.; Rodolf, A. A.; Ivanov, T.; Corrales, E. M.; Kumar, S. S.; Kamariza, M.
10.1101/2025.06.23.661142 — microbiology — Posted on 2025-06-23
652 Metabolite Interactions Mediate Beneficial Alliances Between Bacillus and Trichoderma for Effective Fusarium Wilt Control
Xie, J.; Sun, X.; Wen, T.; Bai, Y.; Qian, T.; Hu, S.; Chen, L.; Wang, P.; Miao, Y.; Zhang, R.; Kovacs, A. T.; Xu, Z.; Shen, Q.
10.1101/2025.06.23.660901 — microbiology — Posted on 2025-06-23
653 Plasma Membrane Damage by Environmental Materials Enhances Cell-Cell Fusion and Impairs Immune Functions of Macrophages
Wu, D.; Zhang, X.; Wang, R.; Livingston, A.; EL Hayek, E.; Xue, X.; Neumann, A. K.; Campen, M.; Liu, M.; Yang, X.
10.1101/2025.06.17.660197 — immunology — Posted on 2025-06-23
654 Dynamic encoding of valence by the anterior cingulate cortex in mice
Goswamee, P.; Saferin, N.; Ganguly, K.; Shah, R.; Seoane, J. S.; Neifer, K. L.; Pearce, R. A.; Burkett, J. P.
10.1101/2025.06.17.660226 — neuroscience — Posted on 2025-06-23
656 Temporal Dynamics of Urinary Extracellular Vesicle Excretion and Cargo in Healthy Subjects over 24 Hours
Upson, S.; Selesky, M.; Greig, M.; Yavuz, H.; Harding, M.; Mallawaarachchi, I.; Ma, J.; Solga, M.; Alwagdani, A.; Musante, L.; Erdbruegger, U.
10.1101/2025.06.17.660244 — physiology — Posted on 2025-06-23
657 The obesity-linked peptide SP16 regulates adipocytes through GIP and insulin receptor
Ngo, T. M. H.; Santhanam, R.; Teufel, D.; Dick, A.; Lam, D.; Klein, H.; Brunner, A.-D.; Pereira, M. M. A.; Bartelt, A.; Pekcec, A.; Giroud, M.
10.1101/2025.06.17.660082 — pharmacology and toxicology — Posted on 2025-06-23
658 Cerebellum metastasis model of HER2-positive breast cancer unveils key role of IL34-induced Arg1+ macrophages.
Cheng, X.; Patel, K. K.; Zhou, B.; Fu, Y.; Cleary, R.; Highkin, M.; Hsia, J.; Jin, X.; Kohn, B.; Prior, J. L.; Michie, M. S.; Sun, R.; Van Swearingen, A. E. D.; Quirk, J. D.; Hagemann, I. S.; Li, Q.; Jain, V.; Gregory, S. G.; Kim, A. H.; Bose, R.
10.1101/2025.06.17.660224 — cancer biology — Posted on 2025-06-23
660 MF-ProtDisMap: protein real-valued distance prediction with fusion of sequence and coevolutionary features
Zhang, Y.; Zhong, S.; Xu, S.; Wang, Z.; Xin, C.; Ni, F.; Yan, F.; Lu, X.; Sun, S.; Wang, H.; Zhang, L.
10.1101/2025.06.17.660102 — bioinformatics — Posted on 2025-06-23
662 Landscape and mutational dynamics of G-quadruplexes in the complete human genome and in haplotypes of diverse ancestry
Chantzi, N.; Liew, S. W.; Wijaya, A.; Chan, C.; Mouratidis, I.; Amaral, E. d. O. S.; Uzun, Y.; Hemberg, M.; Vasquez, K. M.; Kwok, C. K.; Georgakopoulos Soares, I.
10.1101/2025.06.17.660256 — genomics — Posted on 2025-06-23
663 DNA virus-host patterns in lake and marine environments over the last glacial cycle
Boeckel, C.; Lisovski, S.; Stoof-Leichsenring, K.; Weiss, J. F.; Liu, S.; Harms, L.; Herzschuh, U.
10.1101/2025.06.18.660323 — ecology — Posted on 2025-06-23
664 Megafauna show pervasive yet distinct affinity to ocean fronts: the urgent need for adaptive conservation in a warming world
Brito-Morales, I.; Dewitte, B.; Sudre, F.; Rohner, C. A.; Hazen, E. L.; Scales, K. L.; Le Corre, M.; Jaeger, A.; Laran, S.; Bousquet, O.; Sequeira, A. M. M.; Davies, T. E.; Dunn, D. C.; Nel, R.; Hannah, L.; Rossi, V.
10.1101/2025.06.17.660201 — ecology — Posted on 2025-06-23
665 Legal Harvest of Shorebirds and Resident Game Birds on a Caribbean island: A Martinique Case Study
Cox, A. R.; Gallo-Cajiao, E.; Tremblay, F.; Rateau, F.; Urvoy, K.; Laliberte, B.; Boniface, P.; Euphrosine, D.; Lavanne, T.; Roy, C.
10.1101/2025.06.17.660260 — ecology — Posted on 2025-06-23
667 Targeting PI3K Signaling for Broad Inhibition of β-Coronavirus Infection
Xing, J.; Wang, Q.; Chen, N.; Nutsford, A. N.; Sullivan-Hill, B.; Taylor, J. A.; Rewcastle, G.; Flanagan, J. U.; Li, S.; Shepherd, P. R.; Yue, J.; Netzler, N. E.
10.1101/2025.06.22.660949 — microbiology — Posted on 2025-06-23
669 Structural insights into type I and type II Lamassu anti-phage systems
Li, M.; Zhao, X.; Zhao, X.; Li, D.; Xiong, W.; Gao, Z.; Huang, L.; An, L.; Gao, Y.; Feng, Y.; Zhang, K.; Zhang, Y.
10.1101/2025.06.23.660979 — microbiology — Posted on 2025-06-23
670 Environmental context as a key driver of Pseudomonas biocontrol activity against Salmonella.
Vimont, N.; Bastkowski, S.; Savva, G. M.; Bloomfield, S. J.; Mather, A. E.; Webber, M. A.; Trampari, E.
10.1101/2025.06.23.661019 — microbiology — Posted on 2025-06-23
671 Development of a replication-defective MPXV platform for fundamental and therapeutic research
Chen, J.; Hu, L.; Shi, N.; Tian, J.; Zhang, Y.; Tian, S.; Cao, X.; Ha, Z.; Cai, Q.; Lu, Y.; Smith, G. L.; Xie, Y.; Lu, H.; Zhang, P.; Zhang, R.
10.1101/2025.06.21.660854 — microbiology — Posted on 2025-06-23
672 Integrative multi-omic analysis reveals oral microbiome-metabolome signatures of obesity
Shibl, A. A.; Denekew, T. W.; Ahmad, A.; Abdelrazig, S.; Leonor, C.; Utenova, L.; Zhang, G.; AbdelBaqi, M.; Malla, Y.; Arshad, M.; Arnoux, M.; Drou, N.; Abdulle, A.; Ali, R.; Amin, S. A.; Idaghdour, Y.; Jha, A.
10.1101/2025.06.22.659458 — microbiology — Posted on 2025-06-23
674 Toxoplasma effector TgWIP hijacks dendritic cell actin and motility via Nck1/Grb2 and the WAVE complex
Morales, P.; Kramer, D. A.; de Moraes de Siqueira, C.; Brown, A. J.; Sangare, L.; Chen, B.; Saeij, J. P. J.
10.1101/2025.06.22.660983 — microbiology — Posted on 2025-06-23
676 Large-scale phenotyping and comparative genomics reveal genetic features of Listeria persistence in epithelial cells
Milohanic, E.; Lotoux, A.; Bertrand, M.; Douarre, P.-E.; Kortebi, M.; Riveiro, H.; Palma, F.; Lakisic, G.; Fox, E. M.; Guillier, L.; Oevermann, A.; Roussel, S.; Bierne, H.; Pagliuso, A.
10.1101/2025.06.23.661024 — microbiology — Posted on 2025-06-23
681 Mitochondrial Fatty Acid Oxidation is Stimulated by Red Light Irradiation
Herrera, M. A.; Caldeira da Silva, C. C.; Baptista, M. S.; Kowaltowski, A. J.
10.1101/2024.09.12.612633 — biochemistry — Posted on 2025-06-23
682 Contextual modulation and blunted defensive responses to predators in head-fixed and freely moving mice
Ritter, M.; Barreira, L. M. C.; Sach, L.; Hakus, A.; Oektem, S. K.; Bergmann, R.; Voigt, A.; Schmitz, D.; Poirazi, P.; Larkum, M. E.; Sachdev, R.
10.1101/2025.06.09.658679 — animal behavior and cognition — Posted on 2025-06-23
683 Persistent legacy effects on soil microbiota facilitate plant adaptive responses to drought
Ginnan, N. A.; Custodio, V.; Gopaulchan, D.; Ford, N.; Salas-Gonzalez, I.; Jones, D. D.; Wells, D. M.; Moreno, A.; Castrillo, G.; Wagner, M. R.
10.1101/2024.08.26.609769 — microbiology — Posted on 2025-06-23
686 CREB drives acinar cells to ductal reprogramming and promotes pancreatic cancer progression in preclinical models of alcoholic pancreatitis
Srinivasan, S.; Mehra, S.; Jinka, S.; Bianchi, A.; Singh, S.; Dosch, A. R.; Amirian, H.; Krishnamoorthy, V.; Silva, I. D. C.; Patel, M.; Box, E. W.; Garrido, V.; Totiger, T. M.; Zhou, Z.; Ban, Y.; Datta, J.; VanSaun, M.; Merchant, N.; Nagathihalli, N.
10.1101/2024.01.05.574376 — cancer biology — Posted on 2025-06-23
689 Mutations in legume symbiosis genes create a complex selective landscape for rhizobial symbionts
Guha, S.; Bledsoe, R. B.; Sutherland, J.; Epstein, B.; Fry, G. M.; Young, N. D.; Tiffin, P.; Burghardt, L. T.
10.1101/2024.09.11.612462 — evolutionary biology — Posted on 2025-06-23
690 Admixture mapping reveals evidence for multiple mitonuclear incompatibilities in swordtail fish hybrids
Robles, N. V.; Moran, B. M.; Rodriguez Barrera, M. J.; Jofre, G. I.; Gunn, T.; Iverson, E. N. K.; Beskid, S.; Baczenas, J.; Sedghifar, A.; Andolfatto, P.; Brandvain, Y.; Havird, J. C.; Rosenthal, G. G.; Schumer, M.
10.1101/2025.01.30.635158 — evolutionary biology — Posted on 2025-06-23
691 Single-cell profiling reveals a novel RAB13+ endothelial subpopulation and profibrotic mesenchymal cells in the aged human bone marrow
Cenzano, I.; Cocera, M.; Lopez Perez, A. R.; Campos-Dopazo, L.; Ruiz, J.; Sancho, I.; San Martin-Uriz, P.; Aguirre-Ruiz, P.; Sarvide, S.; Vilas-Zornoza, A.; Ripalda-Cemborain, P.; Alignani, D.; Lopez, A.; Minana Barrios, M.; Quilez Agreda, D.; Ye, J.; Lehmann, R.; Sudupe, L.; Abengozar-Muela, M.; Tamariz-Amador, L.-E.; Muinos-Lopez, E.; Saez, B.; Tegner, J.; A. Calvo, I.; Gomez-Cabrero, D.; Prosper, F.
10.1101/2025.01.28.635238 — molecular biology — Posted on 2025-06-23
692 Targeting of the nuclear RNA exosome to chromatin by HP1 affects the transcriptional programs of liver cells.
SOUAIFAN, H.; COSTALLAT, M.; SITKIEWICZ, L.; GODEST, K.; CAMMAS, F.; MANN, C.; MUCHARDT, C.; RACHEZ, C.
10.1101/2025.02.14.638307 — molecular biology — Posted on 2025-06-23
693 Atypical phosphatases drive dissolved organic phosphorus utilization by phosphorus-stressed phytoplankton in the California Current Ecosystem
Steck, V.; Lampe, R. H.; Bhakta, S.; Marrufo, K. C.; Adams, J. C.; Sachdev, E.; Forsch, K. O.; Barbeau, K. A.; Allen, A. E.; Diaz, J. M.
10.1101/2025.04.09.648040 — microbiology — Posted on 2025-06-23
694 Explaining tip-of-the-tongue experiences in older adults: The role of brain-based and cardiorespiratory fitness factors
Rahman, F.; Tsvetanov, K. A.; Feron, J.; Mullinger, K.; Joyce, K.; Gilani, A.; Fernandes, E. G.; Wetterlin, A.; Wheeldon, L. R.; Lucas, S. J. E.; Segaert, K.
10.1101/2023.12.08.570799 — neuroscience — Posted on 2025-06-23
695 Whisker stimulation reinforces a resting-state network in the barrel cortex: nested oscillations and avalanches
Mariani, B.; Guevara, R.; Tambaro, M.; Maschietto, M.; Leparulo, A.; Vassanelli, S.; Suweis, S.
10.1101/2025.06.06.658305 — neuroscience — Posted on 2025-06-23
697 Human Peripheral Nerve-on-a-Chip on a Multiwell Microelectrode Array as a Scalable Preclinical Neurotoxicity Assay
Rountree, C.; Rodriguez, T.; Byrne, E.; Schmidt, E.; Schwarzbach, E.; Dillon, S.; McCrimmon, A.; Terral, M.; Metea, M.; Moore, M. J.; Curley, J. L.
10.1101/2025.06.09.658615 — pharmacology and toxicology — Posted on 2025-06-23
698 Phospholipid Scramblases TMEM16F and Xkr8 regulate distinct features of Phosphatidylserine (PS) externalization and immune regulation in the tumor microenvironment to regulate tumor growth
Birge, R. B.; Gadiyar, V.; Pulica, R.; Aquib, A.; Tranos, J. A.; Varsanyi, C.; Almansa, L. F.; Gaspers, L.; De Lorenzo, M. S.; Kotenko, S. V.; Tripathi, S.; Howell, R. W.; Choudhary, A.; Calianese, D. C.
10.1101/2025.04.17.649445 — cancer biology — Posted on 2025-06-23
699 MicroAge Mission: Experimental Design, Hardware Development and Operational Considerations for a Bespoke Culture System to Support Tissue-Engineered Skeletal Muscle Constructs.
Jones, S. W.; Shigdar, S.; Tollitt, B. R.; Janvier, A.; Mutter, F.; Henstock, J. R.; Ohana, J.; Turner, D. A.; McArdle, C.; Neri, G.; Blackler, W.; Olentsenko, G.; Hoettges, K. F.; McArdle, A.; Jackson, M. J.
10.1101/2025.06.17.660117 — bioengineering — Posted on 2025-06-23
703 TaPGS1 Driven Flavonol Accumulation Delays Endosperm Cellularization and Enlarges Wheat Grains
Wang, J.; Guo, X.; Liu, X.; Jin, Y.; zhao, s.; Liang, W.; Li, M.; Cheng, M.; Dong, H.; Chen, Q.; Chen, Z.
10.1101/2025.06.17.660139 — plant biology — Posted on 2025-06-23
708 A Geometrically Transient Material for Bioelectronic Implants
Olenik, S.; Goodwin, J. D.; Naik, A.; Coatsworth, P.; Cheung, I. C.; Amirghasemi, F.; Sohi, A.; Abedi, E.; Mousavi, M.; Kozlov, A. S.; Salem, V.; Cowburn, A. S.; Güder, F.
10.1101/2025.06.17.660105 — bioengineering — Posted on 2025-06-23
709 Epilogos: information-theoretic navigation of multi-tissue functional genomic annotations
Quon, J.; Reynolds, A. P.; Tripician, N.; Rynes, E. T.; Teodosiadis, A.; Kellis, M.; Meuleman, W.
10.1101/2025.06.18.660301 — genomics — Posted on 2025-06-23
711 The ZNF512B-NuRD complex co-ordinates a neural-specific gene expression program
Francis, H.; Sharifi Tabar, M.; Parsania, C.; Feng, Y.; Giardina, C.; Ibrahim, O.; Singh, K. P.; Gupta, S.; Schmitz, U.; Rasko, J. E.; Bailey, C. G.
10.1101/2025.06.23.660971 — molecular biology — Posted on 2025-06-23
713 Climbing fibers selectively recruit disinhibitory interneurons to enhance dendritic calcium signaling in cerebellar Purkinje cells
Santos-Valencia, F.; Lackey, E.; Norton, A.; Asem, W.; Gaynor, C. S.; ediger, s.; Hemelt, m. E.; Nguyen, T.; Lee, W.-C. A.; Brunel, N.; Hull, C.; regehr, w.
10.1101/2025.06.22.660768 — neuroscience — Posted on 2025-06-23
714 The neural processes underpinning flexible semantic retrieval in visual and auditory modalities
Shao, X.; Zhang, M.; Wang, X.; Gouws, A.; Jackson, R. L.; Smallwood, J.; Krieger-Redwood, K.; Jefferies, E.
10.1101/2025.06.22.660970 — neuroscience — Posted on 2025-06-23
716 Asymmetric distribution of mitochondrial Ca2+ regulators specifies compartment-specific mitochondrial function and neuronal development
Jang, D. C.; Kim, S. Y.; Kim, W. S.; Jung, H.; Chung, C.; Bang, S.; Kim, H. N.; Choi, H. W.; Han, K.; Cho, Y.; Kwon, S.-K.
10.1101/2025.06.23.660978 — neuroscience — Posted on 2025-06-23
717 Phylogenomics of Plasmopara halstedii reveals genomic regions associated with the breakdown of sunflower downy mildew resistance genes
PECRIX, Y.; Dvorak, E.; Labbe, F.; Legrand, L.; CARRERE, S.; Gouzy, J.; Delmotte, F.; Besnard, G.; Godiard, L.
10.1101/2025.06.18.660304 — plant biology — Posted on 2025-06-23
718 Small Extra-Large GTPase-like proteins influence rhizobial symbiosis in Lotus japonicus
Washington, L. J.; Yoshino, T.; Malagoli Franzon, T.; Vera, V.; Scheller, H. V.
10.1101/2025.06.18.660248 — plant biology — Posted on 2025-06-23
719 Lf2 is a knotted homeobox regulator that modulates leaflet number in soybean
Clark, C. B.; Caldwell, D. L.; Zhu, Q.; Provancal, D.; Edwards, A. C.; Song, Q.; Quigley, C. V.; Iyer-Pascuzzi, A. S.; Ma, J.
10.1101/2025.06.20.660812 — plant biology — Posted on 2025-06-23
720 Gene regulatory network analysis of somatic embryogenesis identifies morphogenic genes that increase maize transformation frequency
Renema, J.; Luckicheva, S.; Verwaerde, I.; Aesaert, S.; Coussens, G.; De Block, J.; Grones, C.; Eekhout, T.; De Rybel, B.; Brew-Appiah, R. A. T.; Bagley, C. A.; Hoengenaert, L.; Vandepoele, K.; Pauwels, L.
10.1101/2025.06.22.659756 — plant biology — Posted on 2025-06-23
721 Clade V MLO proteins are bona fide host susceptibility factors required for powdery mildew pathogenesis in Arabidopsis
Bloodgood, D.; Zhang, Q.; Li, P.; Wu, Y.; Pan, M.; Zhou, C.; Hsu, A.; Zhang, J.; Panstrgua, R.; Kessler, S.; He, P.; Shan, L.; Wei, C.-I.; Xiao, S.
10.1101/2025.06.18.660284 — plant biology — Posted on 2025-06-23
723 Parrots and Humans Prefer Pitch Sequences of Intermediate Complexity
Bellmann, O. T.; Hoeschele, M.; Witt, M.; Shair Ali, E.; Chu, P. C.; Bianco, R.
10.1101/2025.06.22.660906 — animal behavior and cognition — Posted on 2025-06-23
725 The dynamics of ciliogenesis in prepubertal mouse meiosis reveal new clues about testicular maturation during puberty
Perez-Moreno, I.; Lopez-Jimenez, P.; Zapata, H.; Perez-Martin, S.; Lopez-Panades, M.; Barbeito, P.; Roig, I.; Garcia-Gonzalo, F. R.; Page, J.; Gomez Lencero, R.
10.1101/2025.06.19.660582 — cell biology — Posted on 2025-06-23
726 Mechanistic characterization of the antiviral effects of Nordihydroguaiaretic Acid against West Nile Virus
Martinez, F.; Ghietto, L. M.; Lingua, G.; Aguilar, J. J.; Gil, P. I.; Gomez, T. I.; Marioni, J.; Nunez-Montoya, S. C.; Konigheim, B.
10.1101/2025.05.10.653272 — microbiology — Posted on 2025-06-23
727 HSP90-mediated stress resilience in male gametophyte of Arabidopsis thaliana
Kahrizi, Z.; Michailidis, C.; Raabe, K.; Fila, J.; Klodova, B.; Rudolf, J.; Prochazkova Schrumpfova, P.; Honys, D.; Fragkostefanakis, S.
10.1101/2025.06.21.660849 — plant biology — Posted on 2025-06-23
728 Identification of an early-heading mutant in Indonesian native rice cultivar: 'Gemdjah Beton'
Nagalla, A. D.; Morita, R.; Ichida, H.; Hayashi, Y.; Shirakawa, Y.; Sato, T.; Fukuta, Y.; Toriyama, K.; Saito, H.; Okumoto, Y.; Abe, T.
10.1101/2025.06.19.660500 — plant biology — Posted on 2025-06-23
729 Arabidopsis RabGDIs are essential for the asymmetric division of zygotes and embryonic patterning
Yin, G.; Wu, Y.; Wang, W.; Dun, S.; Li, S.; Jiang, L.; Liang, Z.; Zhang, Y.; Xiong, F.
10.1101/2025.06.23.660972 — plant biology — Posted on 2025-06-23
730 Multi-Omics Analysis of Heat Stress-Induced Memory in Arabidopsis
Thirumlaikumar, V. P. P.; Yu, L.; Arora, D.; Mubeen, U.; Wisniewski, A.; Walther, D.; Giavalisco, P.; Alseekh, S.; DL Nelson, A.; Skirycz, A.; Balazadeh, S.
10.1101/2025.06.19.660594 — plant biology — Posted on 2025-06-23
731 Remote sensing of endogenous pigmentation by inducible synthetic circuits in grasses
Lee, D.-Y.; Acosta-Gamboa, L.; Saleh, L.; Pathak, S.; Swyers, N.; Morgan, A.; Meerdink, S.; Kuzio, C.; Calderon, S.; Sheng, H.; Kenney, S.; Zare, A.; Gehan, M.; Nusinow, D. A.
10.1101/2025.06.20.660755 — plant biology — Posted on 2025-06-23
733 Serum exosome miR-150-5p in rheumatic heart disease-associated angiogenesis
Sharma, B.; Jain, S.; Singh, L.; Sharma, S.; Kaur, R.; Singh, H.; Chopra, S.; Chakraborti, A.
10.1101/2025.06.13.659484 — molecular biology — Posted on 2025-06-23
736 Longitudinal assessment of DREADD expression and efficacy in the monkey brain
Nagai, Y.; Hori, Y.; Inoue, K.-i.; Hirabayashi, T.; Mimura, K.; Oyama, K.; Miyakawa, N.; Hori, Y.; Iwaoki, H.; Kumata, K.; Zhang, M.-R.; Takada, M.; Higuchi, M.; Minamimoto, T.
10.1101/2024.12.26.630299 — neuroscience — Posted on 2025-06-23
737 Behavioural, biochemical and functional phenotyping of chronic exposure to chlordecone in mice
VULIN, J.; Chauveau, F.; Duret, C.; Humo, M.; Valdebenito, M.; Aufauvre, C.; Vidal, L.; Morignat, E.; Verchere, J.; Decesar, A.; Gaillard, D.; Lakdhar, L.; BARON, T.; LAVISON-BOMPARD, G.; VIDAL, B.
10.1101/2025.06.16.659846 — neuroscience — Posted on 2025-06-23
738 Higher-order and distributed synergistic functional interactions encode information gain in goal-directed learning
Combrisson, E.; Basanisi, R.; Neri, M.; Auzias, G.; Petri, G.; Marinazzo, D.; Panzeri, S.; Brovelli, A.
10.1101/2024.09.23.614484 — neuroscience — Posted on 2025-06-23
739 Antagonistic and Synergistic Roles of Tomato AFP3 Isoforms in Hormonal Regulation and Development
Vittozzi, Y.; Petri, L.; Chiurazzi, M. J.; Lison, P.; Hernandez, C. G.; Majee, A.; Shankar, N.; Burow, M.; Wenkel, S.
10.1101/2025.06.18.660365 — plant biology — Posted on 2025-06-23
740 X-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels
Allsop, R. N.; Boeren, J.; Tan, B. F.; Merzouk, S.; Poovathingal, S.; van Ijcken, W.; Demmers, J. A.; Mira Bontenbal, H.; Gontan Pardo, C.; Gribnau, J.; Pasque, V.
10.1101/2025.06.18.660324 — developmental biology — Posted on 2025-06-23
741 Extended Shine-Dalgarno motifs govern translation initiation in Staphylococcus aureus
Kohl, M. P.; Bahena-Ceron, R.; Chane-Woon-Ming, B.; Kompatscher, M.; Erlacher, M.; Romby, P.; Klaholz, B.; Marzi, S.
10.1101/2025.06.19.660503 — molecular biology — Posted on 2025-06-23
743 Genomics insights reveal multi-year maintenance of a new Deltacoronavirus infecting Seabirds from the Cagarras Island Archipelago Natural Monument, Brazil
Dias, Y. J.; Freitas da Silva, A.; Rodrigues, A.; Gomes, F.; Correa, L.; Resende, P. C.; Siqueira, M.; Galvao Bueno, M.; Ribeiro, T.; Quintana, P. G.; Cunha, L.; Appolinario, L.; Marques Paula Costa, H.; Brito Oliveira, M.; Reischak, D.; Reck, J.; Wallau, G. d. L.; Ogrzewalska, M.
10.1101/2025.06.19.660416 — microbiology — Posted on 2025-06-23
745 Nuclear Receptor Transcription factors promote axon regeneration in the Adult Corticospinal Tract
Sahu, Y.; Banerjee, S.; Kumaran, M.; Sanyal, K.; Konda, M.; Soni, S.; Menon, A. S.; Manjunath, S.; Kesireddy, D. K.; Beji, D. S.; Chermakani, P.; Biswas, A.; Venkatesh, I.
10.1101/2025.06.19.660319 — neuroscience — Posted on 2025-06-23
748 Cohesin forms fountains at active enhancers in C. elegans
Luethi (Isiaka), B.; Semple, J.; Haemmerli, A.; Thapliyal, S.; Ghadage, K.; Stojanovski, K.; D'Asaro, D.; Das, M.; Gilbert, N.; Glauser, D. A.; Towbin, B. D.; Jost, D.; Meister, P.
10.1101/2023.07.14.549011 — genomics — Posted on 2025-06-23
749 Spatially-explicit genomics of An. gambiae s.l uncovers fine-scale population structure and mechanisms of insecticide resistance
Nagi, S. C.; Essandoh, J.; Ato-Egyir, N.; Lucas, E. R.; Miles, A.; Desewu, K.; Williams, I.; Egyir-Yawson, A.; Sedda, L.; Weetman, D.; Donnelly, M. J.
10.1101/2025.06.13.655782 — genomics — Posted on 2025-06-23
750 Med14 phosphorylation shapes genomic response to GLP-1 Agonist
Van de Velde, S.; Yu, J.; Evensen, K. G.; Pakhlevanyan, E.; Williams, A. E.; Shaw, R. J.; Montminy, M.
10.1101/2025.06.17.660196 — genomics — Posted on 2025-06-23
752 Executive Resources Shape the Impact of Language Predictability Across the Adult Lifespan
Schuckart, M. M.; Martin, S.; Tune, S.; Schmitt, L.-M.; Hartwigsen, G.; Obleser, J.
10.1101/2024.05.08.592872 — neuroscience — Posted on 2025-06-23
757 Degraded ecosystem soil and type 2 diabetes gut microbiomes share altered potential metabolism for sugars, lignin and branched-chain fatty acids: a blind spot for global health?
Liddicoat, C.; Eijkelkamp, B. A.; Cavagnaro, T. R.; Robinson, J. M.; Wallace, K. J.; Barnes, A. D.; Harmsworth, G.; Keating, D. J.; Edwards, R. A.; Breed, M. F.
10.1101/2025.03.11.642605 — genomics — Posted on 2025-06-23
758 The tiniest genomes shrink much further: extreme reductive evolution in planthopper symbionts
Michalik, A.; Castillo Franco, D.; Deng, J.; Prus-Frankowska, M.; Stroinski, A.; Lukasik, P.
10.1101/2025.05.16.654412 — evolutionary biology — Posted on 2025-06-23
759 Asynchronous mouse embryo polarization leads to heterogeneity in cell fate specification
Lamba, A.; Zhu, M.; Meglicki, M.; Czukiewska, S.; Balasubramaniam, L.; Hadas, R.; Weishaupt, N.; Patel, E.; Kavanagh, Y. H.; Wang, R.; Jing, N.; Zernicka-Goetz, M.
10.1101/2024.07.26.605266 — developmental biology — Posted on 2025-06-23
760 Model cyanobacterial consortia reveal a consistent core microbiome independent of inoculation source or cyanobacterial host species
Kust, A.; Zorz, J.; Paniker, C. C.; Bouma-Gregson, K.; Krishnappa, N.; Liu, W.; Banfield, J. F.; Diamond, S.
10.1101/2023.12.09.570939 — microbiology — Posted on 2025-06-23
761 Ligand binding represses bacterial histidine kinase activity by inhibiting its dimerization
Sankhe, G. D.; Xing, J.; Xiao, M.; Buglino, J. A.; Li, H.; Jouline, I.; Glickman, M.
10.1101/2025.05.18.654591 — microbiology — Posted on 2025-06-23
763 The Dual Molecular Identity of Vestibular Kinocilia: Bridging Structural and Functional Traits of Primary and Motile Cilia
Xu, Z.; Tavakoli, A.; Kulasooriya, S.; Liu, H.; Tu, S.; Bloom, C.; Li, Y.; Johnson, T. D.; Zuo, J.; Tao, L.; Kachar, B.; He, D. Z. Z.
10.1101/2025.04.16.647417 — neuroscience — Posted on 2025-06-23
764 FiPhoPHA - A fiber photometry python package for post-hoc analysis
Drakopoulos, V.; Reichenbach, A.; Stark, R.; Foldi, C. J.; Jean-Richard-dit-Bressel, P.; Andrews, Z. B.
10.1101/2025.06.12.659422 — neuroscience — Posted on 2025-06-23
766 Breaking the Phalanx: Overcoming Bacterial Drug Resistance with Quorum Sensing Inhibitors that Enhance Therapeutic Activity of Antibiotics
Beasley, J.-M.; Dorjsuren, D.; Jain, S.; Rath, M.; Scheufen Tieghi, R.; Tropsha, A.; Simeonov, A.; Zakharov, A. V.; Muratov, E.
10.1101/2025.01.17.633658 — bioinformatics — Posted on 2025-06-23
767 SCRIPT: Predicting Single-cell Long-range Cis-regulation Based on Pretrained Graph Attention Networks
Zhang, Y.; Wen, B.; Jiao, Y.; Liu, Y.; Guo, X.; Wu, Y.; Li, J.; Han, L.; Xu, Y.; Gao, X.; Qi, Y.; Cheng, Y.; He, Y.; Tian, W.
10.1101/2025.04.27.650894 — bioinformatics — Posted on 2025-06-23
770 Nicotinamide reverses the Warburg effect in Chinese hamster ovary cell culture
Morrissey, J.; Cankorur Cetinkaya, A.; Grassi, L.; Harwood-Stamper, A. J.; Welsh, J.; Kontoravdi, C.
10.1101/2025.06.18.660349 — bioengineering — Posted on 2025-06-22
773 Enriching for Extracellular Vesicles from Human Bone
Wells, C. J.; Holmes, S. M.; Attard, E. G.; Grenier-Pleau, I. J.; Hall, C.; Bonneil, E. J.; Thibault, P.; Rudan, J. F.; Mann, S.; Abraham, S. A.
10.1101/2025.06.18.660234 — cell biology — Posted on 2025-06-22
775 Control of Quiescence and Activation of Human Muscle Stem Cells by Cytokines
Striedinger, K.; Barruet, E.; Atamaniauc, E.; Linquist, K.; Knott, C.; Brack, A.; Pomerantz, J. H.
10.1101/2025.06.21.660874 — cell biology — Posted on 2025-06-23
776 Cell-type specific iron content regulation revealed by single-cell iron quantification
Holdship, P. F.; Teh, M.; Mazurczyk, M.; Costigan, D.; Pironaci, G.; Chuang, H.-W.; Zimmermann, M.; Stoffel, N.; Hilton, R.; Price, D.; Wade, J.; Drakesmith, H.
10.1101/2025.06.22.660918 — cell biology — Posted on 2025-06-23
777 CRISPR RiPCA for Investigating eIF4E-m7GpppX Capped mRNA Interactions
Vega-Hernandez, G.; Duque, J.; Klein, B. J. C.; Soueid, D. M.; Rech, J. C.; Wang, H.; Zhou, W.; Garner, A. L.
10.1101/2025.06.19.660603 — cell biology — Posted on 2025-06-23
778 Advanced human iPSC-based modelling of LMNA-related congenital muscular dystrophy enables development of targeted genetic therapies for muscle laminopathies
Moore, D. P.; Steele-Stallard, H. B.; Pinton, L.; Lionello, V. M.; Rossi, L.; Aghaeipour, A.; Jalal, S.; Wong, C. T. Y.; Clara-Hwang, A.; Bonne, G.; Zammit, P. S.; Tedesco, F. S.
10.1101/2025.06.22.660928 — cell biology — Posted on 2025-06-23
781 Targeting ZNRF3 and RNF43 to Restore Regeneration and Reverse Metabolic Dysfunction-Associated Steatotic Liver Disease
Di Tullio, F.; Yang, S. B.; Yang, L.; Cogliati, B.; Roshan, S.; Guo, K.; Glezer, A.; Conrad, J.; Kumar, S. V.; Almeida, J.; Li, H.; Saeed, S.; Barcena-varela, M.; Bramel, E.; Lozano, A.; Su, L.; Zhao, D.; Pham, H.; Ma, F.; Lujambio, A.; Ma, S.; Dong, Y.; Zhou, H.; Sun, T.
10.1101/2025.06.19.660551 — cell biology — Posted on 2025-06-23
783 Genomic characterization of sub-populations in human pluripotent stem cell-derived retinal progenitor cells that drive retinal layer structure
Iwama, Y.; Masuda, T.; Yoshimura, M.; Watanabe, M.; Friedlander, M.; Nishida, K.; Takahashi, M.; Nikaido, I.; Mandai, M.
10.1101/2025.06.20.660659 — cell biology — Posted on 2025-06-23
784 Evolutionarily diverged on-switch for actin assembly in fungal endocytosis
Sebellin, J.; Kandiyoth, F. B.; Picco, A.; Hakala, M.; Rivier-Cordey, A.-S.; Michelot, A.; Toret, C. P.; Kaksonen, M.
10.1101/2025.06.22.660955 — cell biology — Posted on 2025-06-23
785 Cellular and molecular landscapes of human tendons across the lifespan revealed by spatial and single-cell transcriptomics
Kurjan, A.; Mimpen, J. Y.; Ramos-Mucci, L.; Aksu, A. C.; Buckley, C. D.; Cribbs, A. P.; Baldwin, M. J.; Snelling, S. J. B.
10.1101/2025.06.19.660575 — cell biology — Posted on 2025-06-23
786 Biological evaluation and molecular docking study of Ferrociphenol as an anti-melanogenic agent
Ketata, E.; Baanannou, A.; Ayadi, W.; Pigeon, P.; Neifar, A.; Top, S.; Masmoudi, S.; El Arbi, M.; Jaouen, G.; Gargouri, A.
10.1101/2025.06.20.660698 — cell biology — Posted on 2025-06-23
790 SLFN11 Enhances Cisplatin Sensitivity in Pediatric Cancer via Activation of Stress-Response and Suppression of Survival Pathways
Jabeen, A.; Awartani, D.; Sherif, S.; Ahmed, E. I.; Alanany, R.; Saleh, A.; Hendrickx, W. R. L.; Raynaud, C. M.
10.1101/2025.06.17.659735 — cancer biology — Posted on 2025-06-22
793 Coenzyme A homeostasis regulates hypoxic signalling via UBFD1in triple-negative breast cancer
Grevitt, P.; Maiques, O.; Shah, K. M.; Morales, V.; Gadaleta, E.; Dodel, M.; Bianchi, K.; Gout, I.; Jones, J. L.; Chelala, C.; Plevin, M. J.; Mardakheh, F. K.; Sharp, T. V.
10.1101/2025.06.18.660436 — molecular biology — Posted on 2025-06-22
795 Acetate as a metabolic booster for glucose-based bioproduction in Escherichia coli
Gosselin-Monplaisir, T.; Jallet, D.; Harscoet, E.; Uttenweiler-Joseph, S.; Heux, S.; Millard, P.
10.1101/2025.06.17.659982 — systems biology — Posted on 2025-06-22
797 A multimodal imaging approach for imaging the metabolic changes resulting from bronchopulmonary dysplasia
Gorman, B. L.; Li, Z.; Deutsch, G.; Huyck, H. L.; Beishembieva, N.; Olson, H.; Villazon, J.; Yu, P.; Clair, G.; Pryhuber, G. S.; Shi, L.; Anderton, C. R.
10.1101/2025.06.16.660017 — physiology — Posted on 2025-06-22
799 Cell-Type Specific Single-Cell Signatures Reveal Nephrotoxic Drug Effects
Kuchi, A. S.; Acitores Cortina, J. M.; Liu, H.; Fatapour, Y.; Berkowitz, J.; Tatonetti, N.
10.1101/2025.06.17.660070 — bioinformatics — Posted on 2025-06-22
802 Cholesterol promotes the formation of dimers and oligomers of the receptor tyrosine kinase ROR1
Ward, A.; Baeza-Ballesteros, L. J.; Schuck, R. J.; Garcia-Murria, M. J.; Lamichhane, R.; Mingarro, I.; Barrera, F. N.
10.1101/2025.06.19.660507 — biochemistry — Posted on 2025-06-22
803 Lipid Metabolism and Contact Site Homologs Are Enriched at the Chloroplast Envelope-Thylakoid Interface
LaBrant, E. W.; Smith, C. N.; Torres-Gerena, A. D.; Ishimwe, J.; Huang, F.; Tullis, A.; Litterer, L.; Modi, B.; Naldrett, M.; Altartouri, B.; Roston, R. L.
10.1101/2025.06.20.660776 — biochemistry — Posted on 2025-06-22
804 Discovery of a First-in-Class SLIT2 Binder Disrupting the SLIT2/ROBO1 Axis via DNA-Encoded Library (DEL) Screening
Yuan, S.; Abdelrahman, S.; Garcia-Vazquez, N.; Nada, H.; Calvo Barreiro, L.; Kuncewicz, K.; Gabr, M.
10.1101/2025.06.22.660907 — biochemistry — Posted on 2025-06-22
808 Proteomic Characterization of Spodoptera frugiperda Granulovirus Occlusion Bodies
Masson, T.; Fabre, M. L.; Gomez Bergna, S. M.; Pidre, M. L.; Tongiani, S.; Salvador, R.; Romanowski, V.; Ferrelli, M. L.
10.1101/2025.06.19.660566 — molecular biology — Posted on 2025-06-22
813 Development of the preterm infant gut and gastric residuals microbiome
Moriel, N.; Jones, L.; Harpenas, E.; Rakow, N.; Shmorak, S.; Friedman, S. E.; Shlomai, N. O.; Yassour, M.
10.1101/2025.06.21.660859 — microbiology — Posted on 2025-06-22
817 CDH1 loss remodels gene expression and lineage identity in human mammary epithelial cells
Musick, M.; Ufondu, C. A.; Rowland, C. E.; Sottnik, J. L.; Shackleford, M. T.; Nesiba, C. S.; Ostrander, J. H.; Sikora, M. J.
10.1101/2025.06.20.660633 — cancer biology — Posted on 2025-06-22
820 Neurobiological and Chemical Characterization of the Cyanobacterial Metabolite Veraguamide E
Sotelo, J.; Mofidi, S.; Fofie Kuete, C.; Fosu, K.; Dodd-o, J.; Simcik, R.; Tack, S.; Soto-Reyes, M. J.; Yousuf, M. S.; Caro-Diaz, E. J.; Kumar, V.; Van Horn, W. D.; Kolber, B. J.; Tidgewell, K. J.
10.1101/2025.06.19.660581 — neuroscience — Posted on 2025-06-22
821 MONITORING POPULATION EXTINCTION RISK WITH COMMUNITY SCIENCE DATA
Acevedo-Charry, O.; Ponciano, J. M.; Poli, C. L.; Jeffery, B. M.; Fletcher, R. J.; Echeverry-Galvis, M. A.; Loiselle, B. A.; Robinson, S. K.; Acevedo, M. A.
10.1101/2025.06.19.660569 — ecology — Posted on 2025-06-22
827 Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response
San Felipe, C.; Batra, J.; Muralidharan, M.; Malpotra, S.; Anand, D.; Bauer, R.; Verba, K. A.; Swaney, D. L.; Krogan, N. J.; Grabe, M.; Fraser, J. S.
10.1101/2025.02.16.638509 — biochemistry — Posted on 2025-06-22
830 Visualizing the Dominant GPCR Coupling of Pathogenic Gαo Mutants in GNAO1-Related Disorders
Larasati, Y. A.; Rabesahala de Meritens, C.; Stoeber, M.; Katanaev, V. L.; Solis, G. P.
10.1101/2025.06.19.660437 — cell biology — Posted on 2025-06-22
832 Deep learning-based event classification of mass photometry data for optimal mass measurement at the single-molecule level
Iqbal, K.; Thiele, J. C.; Saman, D.; Peters, J. S.; Thorpe, S.; Tusk, S.; Bardzil, J.; Benesch, J. L. P.; Kukura, P.
10.1101/2025.06.21.660868 — biophysics — Posted on 2025-06-22
833 RNAGenesis: A Generalist Foundation Model for Functional RNA Therapeutics
Zhang, Z.; Jin, R.; Chao, L.; Xu, G.; Zhang, Y.; Zhou, G.; Yin, D.; Guo, Y.; Fu, Y.; Yang, Y.; Huang, K.; Wang, X.; Zhang, J.; Yang, Y.; Yang, Q.; Xu, Z.; E, W.; Zhou, R.; Zhang, X.; Wang, M.; Cong, L.
10.1101/2024.12.30.630826 — bioinformatics — Posted on 2025-06-22
834 Tissue-specific I-Smad mechanisms revealed by structure-function analysis in Drosophila
Simoncek, A. M.; Sviridoff, S. J.; Hays, J. N.; Graichen, N. N.; Sulkowski, M. J.
10.1101/2025.06.20.660739 — cell biology — Posted on 2025-06-22
835 Psychedelics Align Brain Activity with Context
Stoliker, D.; Novelli, L.; Khajehnejad, M.; Biabani, M.; Barta, T.; Greaves, M. D.; Williams, M.; Chopra, S.; Bazin, O.; Simonsson, O.; Chambers, R.; Barrett, F.; Deco, G.; Seth, A.; Preller, K. H.; Carhart-Harris, R.; Sundram, S.; Egan, G. F.; Razi, A.
10.1101/2025.03.09.642197 — neuroscience — Posted on 2025-06-22
841 Essentialome-Wide Multigenerational Imaging Reveals Mechanistic Origins of Cell Growth Laws
Eaton, D. S.; Sanchez, C.; Gutierrez-Lopez, L.; Shenker, J. Q.; Goulev, Y.; Watson, B. R.; Henriot, V.; Garner, E. C.; Justman, Q. A.; Moffitt, J. R.; Paulsson, J.
10.1101/2025.06.10.658525 — systems biology — Posted on 2025-06-22
843 EEG-based Decoding of Auditory Attention to Conversations with Turn-taking Speakers
Van de Ryck, I.; Heintz, N.; Rotaru, I.; Geirnaert, S.; Bertrand, A.; Francart, T.
10.1101/2025.06.20.660726 — neuroscience — Posted on 2025-06-22
844 Convergent and Divergent Brain-Cognition Development
Xie, Y.; Zhang, S.; Orban, C.; Ooi, L. Q. R.; Kong, R.; Floris, D. L.; Zuo, X.-N.; Dhamala, E.; Holmes, A. J.; Uddin, L. Q.; Nichols, T. E.; Di Martino, A.; Yeo, B. T. T.
10.1101/2025.06.06.658294 — neuroscience — Posted on 2025-06-22
846 Hierarchical microstructural tissue growth of the gray and white matter of human visual cortex during the first year of life
Perez, K.; Allen, A.; Tyagi, C.; Tung, S. S.; Fascendini, B.; Yan, X.; Horenziak, J.; Ortiz, D.; Wu, H.; Grill-Spector, K.; Natu, V. S.
10.1101/2025.06.20.660718 — neuroscience — Posted on 2025-06-22
847 A data-driven algorithm to determine 1H-MRS basis set composition
Davies-Jenkins, C. W.; Zollner, H. J.; Simicic, D.; Alcicek, S.; Edden, R. A. E.; Oeltzschner, G.
10.1101/2024.09.11.612503 — neuroscience — Posted on 2025-06-22
848 Non-cell autonomous control of presynaptic remodeling by the hypothalamic autophagy/NPY axis
Cazzolla, G.; Toppe, D.; Krause, G.; Kochlamazashvili, G.; Luetzkendorf, J.; Schedina, I. M.; Kerkhoff, Y.; Reifenstein, E.; von Kleist, M.; Herzog, H.; Albrecht, A.; Schmitz, D.; Haucke, V.; Sigrist, S. J.; Maglione, M.
10.1101/2025.06.20.660653 — neuroscience — Posted on 2025-06-22
854 An advanced head-to-tail mouse embryo model with hypoxia-mediated neural patterning
Balaskas, A.; Kraus, I.; Ozguldez, H. O.; Omgba, P. A.; Buschow, R.; Bolondi, A.; Berlad, I.; Hanna, J. H.; Kretzmer, H.; Bulut-Karslioglu, A.
10.1101/2025.06.17.660116 — developmental biology — Posted on 2025-06-22
855 Development of a protocol utilizing single-cell analysis for the differentiation of human iPSCs into SOX6+ midbrain dopaminergic neurons.
Lyu, G.; Garcia Swinburn, R.; Kreutzmann, J. C.; Xiong, A.; Kojima, R.; Abaurre, C.; Tremolanti, C.; Gellhaar, S.; Uhlen, P.; Svenningsson, P.; Castelo Branco, G.; Dagliyan, O.; Salto, C.; Arenas, E.
10.1101/2025.06.18.660098 — cell biology — Posted on 2025-06-22
859 Auditory corticofugal circuits drive vocalization-guided maternal behavior
LeMessurier, A.; Kaur, G.; Paraiso, J. I.; Agha, A.; Stephens, J.; Froemke, R. C.
10.1101/2023.09.13.557594 — neuroscience — Posted on 2025-06-22
860 Leukemia Inhibitory Factor as a late-stage treatment for delayed white matter loss in concussive head injury
D'Mello, V. d.; Mihailovic, J.; Ali, S.; Sanganahalli, B. G.; Coman, D.; Hyder, F.; Fernando, M.; Mampilly, A.; Kannurpatti, S. S.; Levison, S. W.
10.1101/2025.04.07.647435 — neuroscience — Posted on 2025-06-22
861 Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala
Campbell, J. M.; Cowan, R. L.; Wahlstrom, K. L.; Hollearn, M. K.; Jensen, D.; Davis, T.; Rahimpour, S.; Shofty, B.; Arain, A.; Rolston, J. D.; Hamann, S.; Wang, S.; Eisenman, L. N.; Swift, J.; Xie, T.; Brunner, P.; Manns, J. R.; Inman, C. S.; Smith, E. H.; Willie, J. T.
10.1101/2024.11.11.622161 — neuroscience — Posted on 2025-06-22
864 Ethylene Receptor Gain- and Loss-of-function Mutants Reveal an ETR1-dependent Transcriptional Network in Roots
White, M. G.; Harkey, A.; Muhlemann, J. K.; Olex, A. L.; Pfeffer, N. J.; Houben, M.; Binder, B.; Muday, G. K.
10.1101/2024.06.26.600793 — plant biology — Posted on 2025-06-22
866 Disaggregation Regression and Multi-Model Evaluation for Predicting Dengue Risk in Africa
Poongavanan, J.; Lucas, T. C. D.; Mwanyika, G.; Kraemer, M. U. G.; Lourenco, J.; Dunaiski, M.; de Oliveira, T.; Tegally, H.
10.1101/2025.06.17.660069 — ecology — Posted on 2025-06-21
868 Engineering Escherichia coli FAD synthetase for the biosynthesis of FAD nucleotide analogues results in aminoglycoside antibiotic tolerance
Hazra, A. B.; Mukherjee, A.; Shah, A.; Bhargav, P.; Mahato, S.; Singh, R. K.; Kumar, Y.; Panda, P.; Borkar, J.; Parab, L.; Matange, N.
10.1101/2025.06.21.660729 — microbiology — Posted on 2025-06-21
870 Advanced illumination-imaging reveals photosynthesis-triggered pH, ATP and NAD redox signatures across plant cell compartments
Zheng, K.; Elsässer, M.; Niemeier, J.-O.; Barreto, P.; Cislaghi, A. P.; Hoang, M.; Feitosa-Araujo, E.; Wagner, S.; Giese, J.; Kotnik, F.; Martinez, M. d. P.; Buchert, F. E.; Ugalde, J. M.; Armbruster, U.; Hippler, M.; Meyer, A. J.; Kunz, H.-H.; Maurino, V. G.; Finkemeier, I.; Schallenberg-Rüdinger, M.; Schwarzländer, M.
10.1101/2025.06.16.659786 — plant biology — Posted on 2025-06-21
872 Transcriptomic profiling of Debaryomyces hansenii reveals detoxification and stress responses to benzo(a)pyrene exposure
Padilla-Garfias, F.; Poot-Hernandez, A. C.; Araiza-Villanueva, M.; Calahorra, M.; Sanchez, N. S.; Pena, A.
10.1101/2025.06.17.660189 — biochemistry — Posted on 2025-06-21
873 Mammalian mitochondrial polyphosphate is regulated by the 5-InsP7 synthase IP6K1
Ladke, J. S.; Khan, A.; Singh, A.; Singh, J.; Steck, N.; Jessen, H.; Kolthur-Seetharam, U.; Jaiswal, M.; Bhandari, R.
10.1101/2025.06.17.659843 — biochemistry — Posted on 2025-06-21
874 New iPSC resource with long-read whole genome sequencing characterizations for enhanced in vitro modeling
Scheinfeldt, L. B.; Pompetti, A.; Calendo, G.; Pozner, T.; Grandizio, C.; Smith, G.; Hodges, K.; Gharani, N.; Kusic, D.; Mitchell, M. W.; Turan, N.
10.1101/2025.06.17.660113 — genomics — Posted on 2025-06-21
876 Identification of key bacteria for ecological dynamics in a coastal marine observatory
Mateus-Barros, E.; Flores, E. P.; Zanetti, J.; Griffero, L.; Amann, R.; Alonso, C.
10.1101/2025.06.16.659933 — ecology — Posted on 2025-06-21
878 Reconstitution of human cytochrome P450 activity using a Leishmania cell-free protein expression system
Johnston, W.; Thomson, R. E. S.; Alfaro-Palma, J.; Alexandrov, K.; Speight, R. E.; Gillam, E. M. J.; Behrendorff, J. B.
10.1101/2025.06.20.660707 — synthetic biology — Posted on 2025-06-21
879 DCX Enhances Glioblastoma Metabolism Through Synergistic Regulation of Glutamine Synthesis and Metabolism-Related Genes for Cellular Homeostasis
Ayanlaja, A. A.; Hong, X.; Cheng, B.; Han, Z.; Chang, M.; Kanwore, K.; Adesanya, A. I.; Ayanlaja, M.; Raji, Q.; Iqra, N.; Alphayo-Kambey, P.; Tang, C.; Dong, J.; Zhang, B.
10.1101/2025.06.16.660014 — cancer biology — Posted on 2025-06-21
881 SAIR: Enabling deep learning for protein-ligand lnteractions with a synthetic structural dataset
Lemos, P.; Beckwith, Z.; Bandi, S.; Van Damme, M.; Crivelli-Decker, J.; Shields, B. J.; Merth, T.; Jha, P. K.; De Mitri, N.; Callahan, T. J.; Nish, A.; Abruzzo, P.; Salomon-Ferrer, R.; Ganahl, M.
10.1101/2025.06.17.660168 — biochemistry — Posted on 2025-06-21
882 Extended NGN2 Expression in iPSCs Dramatically Enhances Purity of Neuronal Cultures
Munoz-Estrada, J.; Mostafania, A.; Halwatura, L.; Haghani, A.; Jiang, Y.; Meyer, J. G.
10.1101/2025.06.20.660764 — biochemistry — Posted on 2025-06-21
883 Glycolipid recognition and binding by Siglec-6 hinges on interactions with the cell membrane
D'Andrea, S.; Schmidt, E. N.; Bui, D.; Singh, O.; Han, L.; Mahal, L. K.; Klassen, J. S.; Macauley, M. S.; fadda, e.
10.1101/2025.06.21.660838 — biochemistry — Posted on 2025-06-21
885 Genetic impacts on within-pair DNA methylation variance in monozygotic twins capture gene-environment interactions and cell-type effects
Zhang, X.; Yet, I.; Villicana, S.; Castillo-Fernandez, J.; Mangino, M.; Hottenga, J. J.; Tsai, P.-C.; Min, J.; Falchi, M.; Wong, A.; Boomsma, D.; Ong, K.; van Dongen, J.; Bell, J. T.
10.1101/2025.06.17.659865 — genetics — Posted on 2025-06-21
887 Dysregulated MEG3 in Myotonic Dystrophy 1: nuclear retention, pathological role, and therapeutic correction by antisense conjugates.
Seoane-Miraz, D.; Stoodley, J.; Galindo-Riera, N.; Jad, Y.; Klein, A. F.; Nikel, L.; Lomonosova, Y.; Reine, J.; Camara, S.; Artero, R.; Furling, D.; Wood, M. J.; Varela, M. A.
10.1101/2025.06.20.658327 — molecular biology — Posted on 2025-06-21
888 Downregulation of LATS1/2 Drives Endothelial Senescence-Associated Stemness (SAS) and Atherothrombotic Lesion Formation
Kotla, S.; Lee, J.; Ko, K. A.; Chen, W.; Samanthapudi, V. S. k.; Hoang, O.; Mejia, G.; Li, S.; Schadler, K. L.; Rivera, L. A.; Samperio, K. C. T.; Kim, J. H.; Ostos Mendoza, K. C.; Deswal, A.; Cooke, J. P.; Fujiwara, K.; Palaskas, N. L.; Koutroumpakis, E.; Gi, Y. J.; Pathania, R.; Lorenzi, P. L.; Tan, L.; Madhmud, I.; Hanssen, N. M.; Yvan-Charvet, L.; Chini, E.; Herrmann, J.; Vasquez, H.; Shen, Y. H.; Martin, J. F.; Xu, H.; Seeley, E. H.; Burks, J. K.; Brookes, P. S.; Wang, G.; Le, N.-T.; Abe, J.-i.
10.1101/2025.06.19.660635 — molecular biology — Posted on 2025-06-21
889 Inhibition of pro-atherogenic trimethylamine production by human gut bacteria is not determined by varying chlorogenic acid content in highbush blueberries
McAmis, A. M.; Sweet, M. G.; Chadwick, S.; Ratliff, J. G.; Mengist, M. F.; Bassil, N. V.; Anandh Babu, P. V.; Iorizzo, M.; Neilson, A. P.
10.1101/2025.06.20.660815 — microbiology — Posted on 2025-06-21
890 Scalable single-cell metagenomic analysis with Bascet and Zorn
Gourle, H.; Yakovenko, I.; Verma, J.; Dicken, J.; Albrecht, F.; Mazutis, L.; Normark, J.; Sheng, N.; Strömberg, N.; Löfstedt, T.; Carroll, L. M.; Henriksson, J. M.
10.1101/2025.06.20.660799 — microbiology — Posted on 2025-06-21
892 Phage-based microbiome manipulation elucidates interactions within community context
Hessler, T.; Chiniquy, D.; Adler, B.; Hoff, J.; Tucker, E.; Huddy, R. J.; Sachdeva, R.; Lei, S.; Harrison, S. T. L.; Doudna, J.; Barrangou, R.; Diamond, S.; Deutschbauer, A. M.; Banfield, J. F.
10.1101/2025.06.20.660599 — microbiology — Posted on 2025-06-21
893 A Cas12a Toolbox for Rapid and Flexible Group B Streptococcus Genomic Editing and CRISPRi
Hillebrand, G. H.; Carlin, S. M.; Giacobe, E. L.; Stephenson, H. A.; Collins, J.; Hooven, T. A.
10.1101/2025.06.20.660720 — microbiology — Posted on 2025-06-21
894 The macroecology of immunity: predominant influence of climate on invertebrate immune response
Hasik, A.; Blondeau, M.; Harvey, J.; Groleau, T.; DeBellis, T.; Pedersen, E. J.; Cordoba-Aguilar, A.; Marshall, K. E.; Ferguson, L.; Lessard, J.-P.
10.1101/2025.06.16.659911 — immunology — Posted on 2025-06-21
901 Functional impact of pathogenic Runt domain mutations in Runx2 in vivo: Insights into the skeletal and dental anomalies of cleidocranial dysplasia
Ogawa, S.; Higuchi, S.; Yoshimoto, Y.; Hoshino, M.; Miura, S.; Hamada, A.; Watanabe, H.; Sakuma, T.; Hu, K.; Ogata, S.; Uchibe, K.; Fujimoto, K.; Yamamoto, T.; Okamoto, T.; Kunimatsu, R.; Sotomaru, Y.; Tanimoto, K.; Kondoh, G.; Docheva, D.; Shukunami, C.
10.1101/2025.06.18.660258 — genetics — Posted on 2025-06-21
906 Schizophrenia-associated 22q11.2 deletion elevates striatal acetylcholine and disrupts thalamostriatal projections to produce amotivation in mice
Patton, M. H.; Teubner, B. J. W.; Thomas, K. T.; Freshour, S. L.; Trevisan, A. J.; Schild, A. B.; Ramirez, C. A.; Bikoff, J. B.; Zakharenko, S. S.
10.1101/2025.06.20.660782 — neuroscience — Posted on 2025-06-21
907 Twinfilin-1 phosphorylation in reelin signaling regulates actin dynamics and spine development
DONG, G.; Mori, D.; Matsuzaki, T.; Tanaka, R.; Itoh, N.; Matsui, T.; Sato, A.; Arioka, Y.; Okumura, H.; Fukaya, R.; Kuba, H.; Nagai, T.; Nabeshima, T.; Ikesue, H.; Kohno, T.; Hattori, M.; Kaibuchi, K.; Ozaki, N.; Mizoguchi, H.; Yamada, K.
10.1101/2025.06.18.660483 — neuroscience — Posted on 2025-06-21
909 Sideroflexins enable mitochondrial transport of polar neutral amino acids
Block, S.; Chi, F.; Rosen, P. C.; Pineda, S. S.; Darnell, A. M.; Abbott, K. L.; Pena, I. A.; Heiman, M.; Yilmaz, O. H.; Kory, N.; Vander Heiden, M. G.
10.1101/2025.06.18.660357 — biochemistry — Posted on 2025-06-21
911 Herpes simplex virus-1 fluidizes the nucleus enabling condensate formation
Herzog, N. L.; Kidiyoor, G. R.; Keegan, S.; Korchi, F.; Chenoweth, D. M.; Zhang, H.; Mohr, I.; Wilson, A.; Holt, L. J.
10.1101/2025.06.20.660750 — cell biology — Posted on 2025-06-21
913 Biomechanical simplification of the motor control of whisking
Bresee, C. S.; Luo, Y.; Alade'Fa, J.; Black, M. E.; Kleczka, K. J.; Bush, N. E.; Zhang, K.; Hartmann, M. J.
10.1101/2025.06.21.660818 — neuroscience — Posted on 2025-06-21
914 Cholinergic modulation of dopamine release drives effortful behavior
Touponse, G. C.; Pomrenze, M. B.; Yassine, T.; Mehta, V.; Denomme, N.; Zhang, Z.; Malenka, R. C.; Eshel, N.
10.1101/2025.06.18.660394 — neuroscience — Posted on 2025-06-21
915 Preserved cerebellar functions despite structural degeneration in older adults
de Witte, A.; Matthijs, A.; Parrell, B.; Mantini, D.; Gooijers, J.; Orban de Xivry, J.-J.
10.1101/2025.06.18.660418 — neuroscience — Posted on 2025-06-21
917 The Topological Architecture of Brain Identity
Poetto, S.; Merritt, H.; Santoro, A.; Rabuffo, G.; Battaglia, D. A.; Vaccarino, F.; Saggar, M.; Brovelli, A.; Petri, G.
10.1101/2025.06.20.660792 — neuroscience — Posted on 2025-06-21
919 Neuromorphic hierarchical modular reservoirs
Milisav, F.; Luppi, A. I.; Suarez, L. E.; Lajoie, G.; Misic, B.
10.1101/2025.06.20.660760 — neuroscience — Posted on 2025-06-21
920 Combining Machine Learning and Multiplexed, In Situ Profiling to Engineer Cell Type and Behavioral Specificity
Leone, M. J.; van de Weerd, R.; Brown, A. R.; Noh, M.-C.; Phan, B. N.; Wang, A.; Corrigan, K. A.; Yeramosu, D.; Sestili, H. H.; Arokiaraj, C. M.; Lopes, B. C.; Cherupally, V. K.; Fields, D.; Babu, S.; Srinivasan, C.; Podder, R.; Gadey, L.; headrick, D.; Chen, Z.; Franusich, M. E.; Dum, R.; Lewis, D.; Mathys, H.; Stauffer, W. R.; Seal, R. P.; Pfenning, A. R.
10.1101/2025.06.20.660790 — neuroscience — Posted on 2025-06-21
921 Neural activity flows through cortical subnetworks during speech production
Castellucci, G. A.; MacKay, M.; Kovach, C. K.; Tabasi, F.; Greenlee, J. D. W.; Long, M. A.
10.1101/2025.06.20.660783 — neuroscience — Posted on 2025-06-21
926 Leveraging crystallographic fragment screening, algorithmic merging and digital chemistry to target NCS-1 protein-protein interactions for treatment of neurological disorders
Munoz-Reyes, D.; Fieseler, K. K.; Winokan, M.; Golding, M.; Capkin, E.; Ferla, M.; Perez-Suarez, S.; Tomlinson, C. W. E.; Marples, P. G.; Miro-Rodriguez, C.; Aguado, L.; Mansilla, A.; Fearon, D.; Thompson, W.; von Delft, F.; Sanchez-Barrena, M. J.
10.1101/2025.06.18.660085 — biophysics — Posted on 2025-06-21
927 Condition-dependent, amorphous protein agglomerates control cytoplasmic rheology
Losa, J.; Simon, F.; Linnik, D.; Kaya, S. G.; Stuart, M. C. A.; Stetsenko, A.; de Boer, R.; Ho, F. Y.; Incarnato, D.; Stevens, J.; van Eck, J.; Fraaije, M. W.; Weiss, L. E.; van Teeffelen, S.; Abeln, S.; Guskov, A.; Marrink, S.-J.; Poolman, B.; Heinemann, M.
10.1101/2025.06.17.660151 — biophysics — Posted on 2025-06-21
929 Algal Optics
Goldstein, R. E.; Birwa, S. K.; Yang, M.
10.1101/2025.06.18.660391 — biophysics — Posted on 2025-06-21
932 A balance between nucleating and elongating actin filaments controls deformation of protein condensates
Walker, C.; Mansour, D.; Effiong, U.; Jordan, D.; Wang, L.; Lafer, E. M.; Alvarado, J.; Belardi, B.; Rangamani, P.; Stachowiak, J. C.; Rangamani, P.
10.1101/2025.06.18.660423 — biophysics — Posted on 2025-06-21
934 Multiscale mechanics of granular biofilms
Mansson, L. K.; Warsaw, A. E.; Wilbanks, E. G.; Pitenis, A. A.
10.1101/2025.06.18.660425 — biophysics — Posted on 2025-06-21
936 Enhancer Poising Enables Pathogenic Gene Activation by Noncoding Variants
Hollingsworth, E.; Chen, Z.; Chen, C. X.; Jacinto, S. H.; Liu, T. A.; Kvon, E.
10.1101/2025.06.20.660819 — genomics — Posted on 2025-06-21
938 Fecal proteomics of wild capuchins reveals impacts of season, diet, age, and, sex on gut physiology
Orkin, J. D.; Fournier, A.; Young, D.; Webb, S. E.; Hernandez, S. C.; Jack, K. M.; Campos, F. A.; Dufour, A.; Melin, A. D.
10.1101/2025.06.16.659980 — ecology — Posted on 2025-06-21
939 The genetic origin of fetal growth restriction and mitochondrial complex I dysregulation
Fisher, J. J.; Wang, C. A.; Botha, V. B.; Acharya, S.; Murray, H. C.; Schjenken, J. E.; Pennell, C. E.; Smith, R.
10.1101/2025.06.19.660636 — developmental biology — Posted on 2025-06-21
942 Deep Neural Networks to Register and Annotate Cells in Moving and Deforming Nervous Systems
Atanas, A. A.; Lu, A. K.-Y.; Goodell, B.; Kim, J.; Baskoylu, S.; Kang, D.; Kramer, T. S.; Bueno, E.; Wan, F. K.; Cunningham, K. L.; Weissbourd, B.; Flavell, S. W.
10.1101/2024.07.18.601886 — neuroscience — Posted on 2025-06-21
943 Tracking visual rhythms: a concert of sensory and motor simulation
Kaltenmaier, A.; Gehmacher, Q.; Kok, P.; Davis, M. H.; Press, C.
10.1101/2025.06.18.660330 — neuroscience — Posted on 2025-06-21
944 A Single-Cell Atlas of DNA Methylation in Autism Spectrum Disorder Reveals Distinct Regulatory and Aging Signatures
Eyring, K. W.; Liu, C.; Elhajjaoui, N.; Abuhanna, K. D.; Zhang, Y.; von Behren, Z.; Eskin, E.; Geschwind, D. H.; Luo, C.
10.1101/2025.06.17.660162 — neuroscience — Posted on 2025-06-21
950 Multimodal Analysis of Sepsis-induced Cardiomyopathy in a Baboon Model
Lupu, F.; Abe, T.; Silasi, R.; Keshari, R.; Popescu, N.; Regmi, G.; Matsuzaki, S.; Georgescu, C.; Kudo, M.; Lupu, C.; Humphries, K. M.; Simmons, J.
10.1101/2025.06.16.659963 — pathology — Posted on 2025-06-21
954 Nanofluid-Enhanced Laser Lithotripsy Using Conducting Polymer Nanoparticles
Fan, Q.; Chen, J.; Mishra, A.; Stewart, A.; Anees, F.; Dominguez, J.; Chen, T.-H.; Payne, C.; Lipkin, M.; Zhong, P.; Hsu, P.-C.
10.1101/2024.06.01.596977 — bioengineering — Posted on 2025-06-21
955 Robust-tedana: An automated denoising pipeline for multi-echo fMRI data
Tahayori, B.; Smith, R. E.; Vaughan, D. N.; Tailby, C.; Handwerker, D. A.; Pierre, E. Y.; Jackson, G. D.; Abbott, D. F.
10.1101/2025.06.16.660050 — bioengineering — Posted on 2025-06-21
956 Biocompatible PVDF Nanofibers with Embedded Magnetite Nanodiscs Enable Wireless Magnetoelectric Neuromodulation
Signorelli, L.; Wolters, A.; Duran Toro, V.; Kocar, E.; Wasner, F.; Goldenstein, N. I.; Englhard, J.; Shojaei Baghini, M.; Heidari, H.; Bachmann, J.; Hescham, S. A.; Gregurec, D.
10.1101/2025.06.16.660052 — bioengineering — Posted on 2025-06-21
957 Identification of High Blanchability Donors, Candidate genes and Markers in Groundnut
Shah, P.; Gangurde, S. S.; Senthil, R.; Singh, K.; Singam, P.; Janila, P.; Mayes, S.; Pandey, M. K.
10.1101/2025.06.18.660288 — genomics — Posted on 2025-06-21
963 Single cell transcriptomics in a treatment-segregated cohort exposes a STAT3-regulated therapeutic gap in idiopathic pulmonary fibrosis
McKenna, N.; Ochsner, S. A.; Cohen, A. W.; Cala-Garcia, J.; Echartea, M. E.; Grimm, S. L.; Poli, F.; Castillo, R. C.; Zuluaga, J. D.; Poli, S.; Adams, T. S.; Pineda, R.; Moss, B.; Ryter, S.; Pillich, R. T.; Villalba, J.; Kato, K.; Hecker, L.; Celada, L. J.; Sauler, M.; Koenigshoff, M.; Kaminski, N.; Raby, B.; Agarwal, S. K.; Tsoyi, K.; Coarfa, C.; Rosas, I.
10.1101/2025.06.16.659944 — cell biology — Posted on 2025-06-21
965 Larval environment reshapes mosquito disease risk via phenotypic and molecular plasticity
Chandrasegaran, K.; Walker, M.; Marano, J. M.; Rami, S.; Bisese, A.; Weger-Lucarelli, J.; Lahondere, C.; Robert, M. A.; Childs, L. M.; Vinauger, C.
10.1101/2025.06.16.659972 — physiology — Posted on 2025-06-21
966 Super-resolution microscopy reveals distinct epigenetic states regulated by estrogen receptor activity
Akhshi, T.; Hu, S. S.; Wheeler, E.; Hellriegel, C.; Richardson, D. S.; Cayting, N.; Mvula, W.; Ahmed, B.; Jeselsohn, R.; Zang, C.; Brown, M.
10.1101/2025.06.16.659976 — cancer biology — Posted on 2025-06-21
969 Patterned embryonic invagination evolved in response to mechanical instability
Vellutini, B. C.; Cuenca, M. B.; Krishna, A.; Szałapak, A.; Modes, C. D.; Tomancak, P.
10.1101/2023.03.30.534554 — developmental biology — Posted on 2025-06-21
970 Killer Toxin K28 resistance in yeast relies on COG complex mediated trafficking of the defence factor Ktd1
Laidlaw, K.; Nadir, H.; Milburn, A.; Cruz, M.; Stanislovas, J.; Droop, A.; MacDonald, S.; Andreev, I.; Leech, A.; Ungar, D.; Sadhu, M. J.; MacDonald, C.
10.1101/2024.12.20.629825 — cell biology — Posted on 2025-06-21
971 Plasmodium falciparum DNA repair dynamics reveal unique roles for TLS polymerases and PfRad51 in genome diversification
Vishwanatha, A.; Zhang, X.; Liu, Y. J.; Leung, A.; Herring, M.; Chan, A.; Calhoun, S.; Deitsch, K. W.; Kirkman, L.
10.1101/2025.04.07.647301 — microbiology — Posted on 2025-06-21
972 Nociceptor Neurons Control Pollution-Mediated Neutrophilic Asthma
Wang, J.-C.; Kulle, A.; Crosson, T.; Reza Nikpoor, A.; Gupta, S.; Roger, A.; Rafei, M.; Thanabalasuriar, A.; Talbot, S.
10.1101/2024.08.22.609202 — immunology — Posted on 2025-06-21
973 Prevalence of Heartwater in Guadeloupe (2024): Stable endemicity and Evidence of Spread to Les Saintes
Dufleit, V.; Guerrini, L.; Dhune, M.; Viry, L.; Belfort, A.; Jacquet-Cretides, L.; Deddy, J.; Cozier, J.; Naves, M.; Arthein, L.; Sammut, T.; Pezeron, M.; Rodrigues, V.; MEYER, D. F.; Etter, E.
10.1101/2025.06.11.659135 — immunology — Posted on 2025-06-21
975 Parameterization of intraoperative human microelectroderecordings: Linking action potential morphology to brainanatomy
Baker, M. R.; Klassen, B. T.; Jensen, M.; Valencia, G. O.; Heydari, H.; Ince, N. F.; Muller, K. R.; Miller, K. J.
10.1101/2025.01.20.633934 — neuroscience — Posted on 2025-06-21
977 Droplet growth, Ostwald's rule, and emergence of order in Fused in Sarcoma
Maksudov, F.; Mugnai, M.; Dominguez, L.; Makarov, D.; Thirumalai, D.
10.1101/2025.05.11.653346 — biophysics — Posted on 2025-06-21
981 Limitations of acyclovir and identification of potent HSV antivirals using 3D bioprinted human skin equivalents
Ellison, S. T.; Hayman, I.; Derr, K.; Derr, P.; Frebert, S.; Itkin, Z.; Shen, M.; Jones, A.; Olson, W.; Corey, L.; Wald, A.; Johnston, C. M.; Fong, Y.; Ferrer, M.; Zhu, J.
10.1101/2024.12.04.626896 — bioengineering — Posted on 2025-06-21
983 An HIV-1 Reference Epitranscriptome
Bosmeny, M. S.; Pater, A. A.; Zhang, L.; Larkai, L.; Sha, B. E.; Lyu, Z.; Damha, M. J.; Mamede, J. I.; Gagnon, K. T.
10.1101/2025.01.30.635805 — genomics — Posted on 2025-06-21
984 Substrate-specific regulation of the mTORC1 pathway by G protein-coupled receptors
Atkinson, S. J.; Negoita, F.; Ritchie, W. V.; Thompson, K.; Sakamoto, K.; Thompson, D.; Hislop, J. N.; Hatakeyama, R.
10.1101/2024.09.18.613687 — cell biology — Posted on 2025-06-21
987 Polyamines regulate cell fate by altering the activity of histone-modifying enzymes
Emmons-Bell, M.; Sundquist, A.; Rabon, M. R.; Forsyth, G.; Oldeman, S.; Ayyappan, S.; Gardikioti, A.; de Souza, R.; Coene, J.; Kamel, M.; Fuchs, H. A.; Sudunagunta, V. S.; Stewart, E. M.; Verhelst, S.; Smeeton, J.; Viny, A. D.; Musselman, C. A.; Schvartzman, J. M.
10.1101/2024.07.02.600738 — cell biology — Posted on 2025-06-21
990 Long noncoding RNA HSCHARME is altered in human cardiomyopathies and promotes stem cell-derived cardiomyocyte differentiation by splicing regulation.
Buonaiuto, G.; Desideri, F.; Setti, A.; Palma, A.; D'Angelo, A.; Storari, G.; Santini, T.; Laneve, P.; Trisciuoglio, D.; Ballarino, M.
10.1101/2024.11.06.622297 — molecular biology — Posted on 2025-06-21
991 Whole Virion Proteomics of HCMV Reveals that gpUL141 is a Virion Component that Regulates Envelope Glycoprotein Composition to Protect Against Humoral Immunity
Bentley, K.; Statkute, E.; Murrell, I.; Fielding, C.; Antrobus, R.; Preston, H.; Kerr, L.; Cochrane, D.; Brizic, I.; Lehner, P. J.; Wilkinson, G. W.; Wang, E. C. Y.; Graham, S. C.; Weekes, M. P.; Stanton, R. J.
10.1101/2024.11.29.626001 — microbiology — Posted on 2025-06-21
993 Assessing the robustness of deep learning based brain age prediction models across multiple EEG datasets
Tveitstoel, T.; Tveter, M.; Hatlestad-Hall, C.; Hammer, H. L.; Engemann, D.; Haraldsen, I.
10.1101/2025.05.20.655022 — neuroscience — Posted on 2025-06-21
998 Dissecting origins of wiring specificity in dense reconstructions of neural tissue
Harth, P.; Udvary, D.; Boelts, J.; Macke, J. H.; Baum, D.; Hege, H.-C.; Oberlaender, M.
10.1101/2024.12.14.628490 — neuroscience — Posted on 2025-06-21
1001 Two time scales of adaptation in human learning rates
Simoens, J.; Braem, S.; Verbeke, P.; Chen, H.; Mattioni, S.; Chai, M.; Schuck, N. W.; Verguts, T.
10.1101/2025.06.05.658048 — neuroscience — Posted on 2025-06-21
1004 Tamarixia citricola Hansson and Guerrieri sp. nov. (Hymenoptera: Eulophidae): a new parasitoid of Diaphorina citri Kuwayamava (Hemiptera: Psyllidae) found during a classical biological control program in Cyprus
Urbaneja, A.; Perez-Hedo, M.; Seraphides, N.; Melifronidou- Pantelidou, A.; Giallouridou, S.; Markou, L.; Stavrinides, M.; Kaponas, C.; Ruiz-Rivero, O.; Morgan, D. J. W.; Hansson, C.; Hoddle, M. S.; Tena, A.; Guerrieri, E.
10.1101/2025.06.16.660002 — zoology — Posted on 2025-06-21
1005 Orco regulates the circadian activity of pheromone-sensitive olfactory receptor neurons in hawkmoths
Vijayan, A.; Forlino, M.; Chang, Y.; Rojas, P.; Schroeder, K.; Schneider, A. C.; Garcia, M. E.; Stengl, M.
10.1101/2025.06.17.659282 — physiology — Posted on 2025-06-21
1006 Prediction of Aggregation Prone Regions in Proteins Using Deep Neural Networks and Their Suppression by Computational Design
Cima, V.; Kunka, A.; Planas-Iglesias, J.; Grakova, E.; Havlasek, M.; Subramanian, M.; Beloch, M.; Marek, M.; Slaninova, K.; Damborsky, J.; Prokop, Z.; Bednar, D.; Martinovic, J.
10.1101/2024.03.06.583680 — bioinformatics — Posted on 2025-06-21
1008 Alveolar epithelial cell plasticity and injury memory in human pulmonary fibrosis
Adams, T. S.; Schupp, J. C.; Balayev, A.; Khoury, J.; Justet, A.; Nikola, F.; Laurens, D. S. J.; Garcia, J. C.; Zapata-Ortega, M.; Panayiotis, B. V.; McDonough, J. E.; Ahangari, F.; Koenigshoff, M.; Ding, J.; Homer, R. J.; Rosas, I. O.; Yan, X.; Vanaudenaerde, B. M.; Wuyts, W. A.; Kaminski, N.
10.1101/2025.06.10.658504 — cell biology — Posted on 2025-06-21
1009 Advancing Ligand Binding Affinity Prediction with Cartesian Tensor-Based Deep Learning
Yu, J.; Sheng, X.; Fan, Z.; Wang, Z.; Cao, D.; Hao, Y.; Zhang, Y.; Shao, P.; Ma, H.; Cao, T.; rao, J.; Chen, M.; Chen, K.; Li, X.; Teng, D.; Luo, X.; Wang, M.; Zhang, S.; Zheng, M.
10.1101/2025.06.04.657800 — molecular biology — Posted on 2025-06-21
1012 Cellulase secretion by engineered Pseudomonas putida enables growth on cellulose oligomers.
Smith, M. R.; Moffitt, K.; Holdsworth, W.; Luna-Flores, C. H.; Goyal, M.; Beliaev, A.; Speight, R. E.; Behrendorff, J. B.
10.1101/2025.06.19.659671 — synthetic biology — Posted on 2025-06-20
1015 Tree bark as a substrate for mycelium-bound composites with two Ganoderma species
Felle, T. K.; Estenfelder, J.; Wenig, C.; Berendt, F.; Eder, M.; Cheng, T.; Benz, J. P.
10.1101/2025.06.16.659851 — bioengineering — Posted on 2025-06-20
1017 Differential DNA methylation in blood in nuclear genes that encode mitochondrial proteins in mild cognitive impairment and Alzheimers disease
Boruch, A. E.; Madrid, A.; Papale, L. A.; Bergmann, P. E.; Renteria, I. S.; Faasen, S.; Cook, D. B.; Alisch, R. S.; Hogan, K. J.
10.1101/2025.06.16.659556 — genomics — Posted on 2025-06-20
1019 Cytokine-induced memory-like responses in endothelial cells link chronic inflammation to vascular disease risk
Le, K. T. T.; Keur, N.; Middelkamp, H.; Do, T. L.; Berg, A. v. d.; Orlova, V.; Joosten, L. A.; Netea, M.; Wijmenga, C.; Jonkers, I.; Withoff, S.; Meer, A. V. d.; Kumar, V.
10.1101/2025.06.16.659872 — molecular biology — Posted on 2025-06-20
1020 Metabolic and genomic adaptations of Salmonella Typhimurium grown on itaconate
Pierscianowski, J.; Diaconescu-Grabari, S.; Chowdhury, F. R.; Lupien, A.; Findlay, B. L.; Auclair, K.
10.1101/2025.06.20.660670 — microbiology — Posted on 2025-06-20
1021 Glial cells promote infection by neurotropic Influenza A viruses in vitro
Rieke, N.; Rohde, M.; Kaeune, M.; Gabele, L.; Muesken, M.; Michaelsen-Preusse, K.; Hosseini, S.; Korte, M.; Sieben, C.
10.1101/2025.06.20.660606 — microbiology — Posted on 2025-06-20
1022 Establishing Conserved Biosynthetic Gene Clusters of the Phylum Myxococcota
Khanal Pokharel, S.; Shehata, N.; Ahearne, A.; Knehans, T.; Bailey, C. B.; Boudreau, P. D.; Stevens, D. C.
10.1101/2025.06.19.660557 — microbiology — Posted on 2025-06-20
1024 PAH-former: Transfer Learning for Efficient Discovery of Pulmonary Arterial Hypertension-Associated Genes
Kawakami, T.; Hosokawa, S.; Masamichi, I.; Kurozumi, A.; Tanaka, R.; Minatsuki, S.; ishida, J.; Isagawa, T.; Kodera, S.; Takeda, N.
10.1101/2025.06.16.660027 — bioinformatics — Posted on 2025-06-20
1025 Lipid nanoemulsion incorporating DOTAP reverse micelles as clinically translatable carriers of ALDH inhibitors for lung cancer therapy
Irujo, M.; Poussereau, L.; Ezziani, M.; Joubertt, C.; Prunier, C.; Vollaire, J.; Josserand, V.; Sarazin, C.; Fenel, D.; Zarkadas, E.; Perez, M.; Texier, I.; Gaudin, A.
10.1101/2025.06.16.659868 — bioengineering — Posted on 2025-06-20
1030 Bacteriophage-Mimetic DNA Origami Needle for Targeted Membrane Penetration and Cytosolic Cargo Delivery
Samanta, A.; Malle, M. G.; Tsang, E.; Omer, M.; Skaanning, M. K.; Kjems, J.; Gothelf, K. V.
10.1101/2025.06.16.659898 — biochemistry — Posted on 2025-06-20
1033 Spleen-derived Small Extracellular Vesicles Protect against Myocardial Infarction via Mediating Spleen-heart Crosstalk
Liu, K.; Luo, Y.; Liao, W.; Chen, R.; Chen, T.; Huang, H.; Xu, J.; Fang, F.; Lin, D.; Gu, T.; Chen, Q.; Yang, B. B.; Chen, W.; Zhang, L.
10.1101/2025.06.16.660039 — molecular biology — Posted on 2025-06-20
1034 Stony coral tissue loss disease (SCTLD) destabilizes the coral microbiome
Nandi, S.; Stephens, T. G.; Walsh, K.; Garcia, R.; Villalpando, M. F.; Sellares-Blasco, R. I.; Zubillaga, A. L.; Croquer, A.; Bhattacharya, D.
10.1101/2025.06.19.660612 — microbiology — Posted on 2025-06-20
1035 Discovery of orally bioavailable Zika and West Nile Virus antiviral compounds targeting the NS2B-NS3 protease
Kenton, N. T.; Barr, H.; Cherepakha, A.; Coelmont, L.; Collard, C.; Cousins, D.; Davies, G. H. M.; Degtyarenko, O.; Dirksen, A.; Elbrecht, D.; Fearon, D.; Gayvert, J.; Griffen, E.; Jochmans, D.; Kaptein, S.; Kliatskiy, P.; Kochetkov, A.; Kordubailo, M.; Lahav, N.; London, N.; Maas, E.; Marples, P.; Nady, N.; Neyts, J.; Nguyen, L.; Ni, X.; Ogorodnik, Y.; Robinson, M. C.; Simpson, C. T.; Tarabara, I.; Tkachenko, A.; von Delft, A.; von Delft, F.; Yakymenko, O.; Lee, A. A.
10.1101/2025.06.19.660642 — microbiology — Posted on 2025-06-20
1036 New Histone H4 variant and H2B variant Exhibits Distinct Genomic Locations, Chromatin Affinities, and Dynamics Throughout Life Cycle and Cell Cycle of Trypanosoma cruzi
Roson, J. N.; Loterio Silva, M.; Silva, H. G.; Rodrigues, T.; Silva, N. S. d. L.; Gachet-Castro, C.; Costa-Silva, H. M.; Viala, V. L.; Shenkman, S.; Elias, M. C.; da Cunha, J. P. C.
10.1101/2025.06.20.660671 — microbiology — Posted on 2025-06-20
1038 Pectobacterium sinaloense sp. nov., a novel phytopathogenic species isolated from potato plants in Mexico
Valdez-Lopez, J. L.; Palafox-Leal, N. L.; Santos-Lopez, G.; Fantino, E. I.; Kukavica, I.; Levesque, R. C.; Mendez-Lozano, J.; Mora-Zamudio, C. I.; Rodriguez-Negrete, E. A.; Santos-Cervantes, M. E.; Leyva-Lopez, N. E.; Perez-Lopez, E.
10.1101/2025.06.20.660644 — microbiology — Posted on 2025-06-20
1039 Pp6-Pfkfb1 axis modulates intracellular bacterial proliferation by orchestrating host-pathogen metabolic crosstalk
Fan, L.; Sun, Y.; Lou, F.; Fang, Z.; Ding, W.; Li, X.; Li, Y.; Shen, Q.; Deng, S.; Liang, J.; Zhang, F.; Tang, S.; Wang, Z.; Cai, X.; Tong, J.; Xu, Z.; Zou, J.; Yang, Q.; Wang, H.
10.1101/2025.06.20.660667 — microbiology — Posted on 2025-06-20
1040 Klebsiella pneumoniae remodels its Kdo2-lipid A in a TLR4-dependent manner to adapt to the macrophage intracellular environment
Bartholomew, T. L.; sa=Pessoa, J.; Lancaster, R.; Zhang, N.; Wojtania-O'Farrell, K.; Hancock, S. J.; Mills, G.; Kissenpfennig, A.; Bengoechea, J.
10.1101/2025.06.20.660740 — microbiology — Posted on 2025-06-20
1044 Transient Dietary Changes Modulate Inflammatory Disease Trajectory in the Lean State
Jiang, Z.; Tayeri, J. M.; Tabuchi, C.; Gayer, S. G.; Yoo, A.; Sun, I.-H.; Wang, J.; Yin, H.; Chuah, S. S.; Deshpande, P.; Johri, V.; Davidson, B.; Tsui, J.; Kuhn, N. F.; Courau, T.; Combes, A. J.; Gardner, J. M.; Bapat, S. P.
10.1101/2025.06.15.659784 — immunology — Posted on 2025-06-20
1046 Gene expression profile dynamics of earthworms exposed to ZnO and ZnO:Mn nanomaterials
van Lingen, H. J.; Ke, C.; Saccenti, E.; Lada, Z. G.; Baccaro, M.; van den Brink, N. W.; Suarez-Diez, M.
10.1101/2025.06.16.660036 — systems biology — Posted on 2025-06-20
1047 Mind the Gap: An Embedding Guide to Safely Travel in Sequence Space
Wu, A.; Trolliet, Q.; Rajendran, A.; Lala, J.; Angioletti-Uberti, S.
10.1101/2025.06.19.660524 — synthetic biology — Posted on 2025-06-20
1053 Satb1 integrates cohesin mediated genome organization and transcriptional regulation during T cell development
Madhok, A.; Patta, I.; Desai, I.; Tayyab, M.; Choudhary, V.; Vishwakarma, S.; Saha, S.; Lahesmaa, R.; Narlikar, G.; Galande, S.
10.1101/2025.06.19.657327 — immunology — Posted on 2025-06-20
1055 Epigenetic Subtypes of High-Grade T1 Bladder Cancer Reveal Intra-Tumor Heterogeneity and Distinct Interactions with Tumor Microenvironment.
Bellmunt, J.; Xie, Y.; Juanpere, N.; Munoz, M.; Kukreja, S.; Liria, S.; Li, R.; Qiu, X.; Jiang, Y.; Font-Tello, A.; Nunez, M.; Epstein, I.; Hernandez, S.; Lorenzo, M.; Menendez, S.; Choueiri, T. K.; Brown, M. C.; LONG, H. W.; Cejas, P.
10.1101/2025.06.20.659124 — cancer biology — Posted on 2025-06-20
1056 NKX2-5 congenital heart disease mutations show diverse loss and gain of epigenomic, biochemical and chromatin search functions underpinning pathogenicity
Ward, A. O.; Schonrock, N.; McCann, A. J.; Phanor, S. K.; Kock, K. H.; Kurland, J. V.; Wu, F.; Murray, N. J.; Walshe, J.; Alankarage, D.; Dunwoodie, S. L.; Meunier, F. A.; Francois, M.; Bulyk, M. L.; Ramialison, M.; Harvey, R. P.
10.1101/2025.06.20.659510 — genomics — Posted on 2025-06-20
1057 Host mRNA 3'-end processing machinery are critical binding partners during dengue virus infection
Tan, M. J. A.; Mohamed Naim, A. N.; Lim, Y. T.; Sobota, R. M.; Hibberd, M. L.; Vasudevan, S. G.
10.1101/2025.06.20.659860 — microbiology — Posted on 2025-06-20
1058 Early disruption of the innate-adaptive immune axis in vivo after infection with virulent Georgia2007/1 ASFV
Tng, P. Y.; Al-Adwani, L.; Goatley, L. C.; Portugal, R.; Rathakrishnan, A.; Netherton, C. L.
10.1101/2025.06.18.660190 — immunology — Posted on 2025-06-20
1059 Behavioral Signature of Trihexyphenidyl in The Tor1a (DYT1) Knockin Mouse Model of Dystonia
Qader, A. A.; Donsante, Y.; Markowitz, J. E.; Jinnah, H. A.; Pandarinath, C.; Hess, E. J.
10.1101/2025.06.17.659360 — neuroscience — Posted on 2025-06-20
1061 The equilibrium between two quaternary assembly states determines the activity of SPOP and its cancer mutants
Cuneo, M. J.; Güllülü, O.; Ammar, M.-R.; Gui, X.; Churion, K.; Turk, M.; O'Flynn, B.; Sabri, N.; Mittag, T.
10.1101/2025.06.19.659812 — biophysics — Posted on 2025-06-20
1067 Expanded gene targeting in RNA hacking with G-tract-supply Staple oligomer
Kida, T.; Hasegawa, Y.; Kato, M.; Ohtani, M.; Matsumoto, A.; Taniguchi, R.; Ohno, R.; Sugiyama, H.; Ihara, T.; Hagihara, M.; Sato, S.-i.; Katsuda, Y.
10.1101/2025.06.17.660051 — bioengineering — Posted on 2025-06-20
1068 Feedback regulation of iron-sulfur cluster biogenesis
Stuteley, S. M.; Chen, J.; Wang, J.; Dawes, S. S.; Baker, E. N.; Squire, C. J.; Pandelia, M.-E.; Bashiri, G.
10.1101/2025.06.15.659787 — biochemistry — Posted on 2025-06-20
1071 Metabolomic Profiling of Ashwagandha (Withania somnifera): Linking Bioactive Compounds to Functional Therapeutic Roles
Tripathi, G.; Bindal, V.; Yadav, M.; Sharma, N.; Pandey, S.; Mathew, B.; Sharma, N.; Yadav, S.; Sharma, V.; Sharma, S.; Sarin, S. K.; Maras, J. S.
10.1101/2025.06.16.659832 — pharmacology and toxicology — Posted on 2025-06-20
1072 Photocrosslinked mucoadhesive hyaluronic acid hydrogel for transmucosal drug delivery
Asamoah, S.; Pravda, M.; Snejdrova, E.; Cepa, M.; Jiri, M.; Gruber-Traub, C.; Velebny, V.
10.1101/2025.06.14.659729 — pharmacology and toxicology — Posted on 2025-06-20
1076 Accelerating k-mer-based sequence filtering
Martayan, I.; Vandamme, L.; Constantinides, B.; Cazaux, B.; Paperman, C.; Limasset, A.
10.1101/2025.06.16.659853 — bioinformatics — Posted on 2025-06-20
1080 Single-Cell Spatial Mapping of Human Kidney Development Reveals the Critical Role of the Local Microenvironment in Cell Fate Decisions
Levinsohn, J.; Grindel, S.; Dumoulin, B.; Abedini, A.; Huang, A.; Levin-Klein, R.; Weicz, B.; Rabinowitz, G.; Bergeson, A. M.; Ha, E.; Klotzer, K. A.; Zhang, N.; Titchenell, P.; Li, M.; Park, J.-S.; Finn, L. S.; Sasaki, K.; Beckerman, P.; Pleniceanu, O.; Hughes, A. J.; Susztak, K.
10.1101/2025.06.15.659579 — genomics — Posted on 2025-06-20
1083 LiaS-dependent activation of the MadR regulon enables cross-talk between Enterococcus faecalis cell envelope defense systems
Hood, K. S.; Rizvi, S. A.; Hoppe-Elsholz, G. A.; Streling, A. P.; Panesso, D.; Pratap, S.; Shamoo, Y.; Arias, C. A.; Miller, W. R.
10.1101/2025.06.19.660511 — microbiology — Posted on 2025-06-20
1084 Human myelocyte and metamyelocyte-stage neutrophils suppress tumor immunity and promote cancer progression
Liu, W.; Shi, T.; Lu, C.; Che, K.; Zhang, Z.; Luo, Y.; Hirschhorn, D.; Wang, H.; Liu, S.; Wang, Y.; Liu, S.; Sun, H.; Lu, J.; Liu, Y.; Shi, D.; Ding, S.; Xu, H.; Lu, L.; Xu, J.; Jun, X.; Liang, Y.; Merghoub, T.; Jia, W.; Li, Y.
10.1101/2025.06.14.659663 — immunology — Posted on 2025-06-20
1085 Muscle control of an extra robotic digit
Russ, J. P.; Dowdall, L.; Cenciarelli, F.; Goodridge, K.; Ziman, M.; Dimitrov, H.; Clode, D.; Makin, T. R.
10.1101/2025.06.18.658087 — neuroscience — Posted on 2025-06-20
1086 A Human Tumor-Immune Organoid Model of Glioblastoma
Baisiwala, S.; Fazzari, E.; Li, M. X.; Martija, A.; Azizad, D. J.; Sun, L.; Herrera, G.; Phan, T.; Monteleone, A.; Nathanson, D. A.; Wang, A. C.; Kim, W.; Everson, R. G.; Patel, K. S.; Liau, L. M.; Prins, R. M.; Bhaduri, A.
10.1101/2025.06.16.660009 — cancer biology — Posted on 2025-06-20
1091 Cis-regulation of gene expression between sexes and life stages in Rumex hastatulus
Yuan, M.; Sacchi, B. M.; Choudhury, B. I.; Barrett, S. C. H.; Stinchcombe, J. R.; Wright, S. I.
10.1101/2025.06.16.659834 — evolutionary biology — Posted on 2025-06-20
1092 Metabolite correlation networks reveal complex phenotypes of adaptation-driving mutations
Samuel, S.; Jasinska, W.; Sternlicht, E.; Nikelshparg, M.; Kleiner, D.; Pilosof, S.; Bershtein, S.
10.1101/2025.06.17.660120 — evolutionary biology — Posted on 2025-06-20
1093 MiTo: tracing the phenotypic evolution of somatic cell lineages via mitochondrial single-cell multi-omics
Cossa, A.; Dalmasso, A.; Campani, G.; Bugani, E.; Caprioli, C.; Bulla, N.; Tirelli, A.; Zhan, Y.; Pelicci, P. G.
10.1101/2025.06.17.660165 — bioinformatics — Posted on 2025-06-20
1094 Predicting the Evolutionary and Functional Landscapes of Viruses with a Unified Nucleotide-Protein Language Model: LucaVirus
Pan, Y.-F.; He, Y.; Liu, Y.-Q.; Shan, Y.-T.; Liu, S.-N.; Liu, X.; Pan, X.; Bai, Y.; Xu, Z.; Wang, Z.; Ye, J.; Holmes, E. C.; Li, B.; Chen, Y.-Q.; Li, Z.-R.; Shi, M.
10.1101/2025.06.14.659722 — bioinformatics — Posted on 2025-06-20
1099 Variation in response to water availability across Phlox species
Steinecke, C.; Tabin, J. A.; Caven, J.; Hale, C. O.; Serrato-Capuchina, A.; Hopkins, R.
10.1101/2025.06.17.660163 — evolutionary biology — Posted on 2025-06-20
1102 Simple 3D-Printed Stirred Bioreactor Enhances Retinal Organoid Production Via Improved Oxygenation
Schwab, K.; Hwang, P.; Nam, K.; Batz, Z.; Hiriyanna, S.; Regent, F.; Morgan, N.; Lelkes, P.; Li, T.
10.1101/2025.06.13.659558 — bioengineering — Posted on 2025-06-20
1104 Induction of meningioma stem signature via hydrogel reprogramming and application of meningioma stem cell marker CXCR4 to pathological diagnosis and treatment.
Oda, Y.; Tsuda, M.; Wang, L.; Suzuka, J.; Yuzawa, S.; Ise, K.; Habiba, U.; He, J.; Tanikawa, S.; Sugino, H.; Tanei, Z.-i.; Mawrin, C.; Gong, J. P.; Tanaka, S.
10.1101/2025.06.14.659672 — bioengineering — Posted on 2025-06-20
1106 Resilience in zebrafish embryoids
Joavnic, S.; Eckert, J.; Savy, T.; Peyrieras, N.
10.1101/2025.06.18.660370 — developmental biology — Posted on 2025-06-20
1108 Pseudovirus-Mediated Proximity Labeling Identifies Candidate Host Cell Membrane Proteins Involved in Viral Attachment
Kotani, N.; Iwasa, K.; Amimoto, T.; Yamashita, C.; Komatsu, K.; Narimichi, Y.; Wakabayashi, Y.; Kurebayashi, Y.; Horiuchi, Y.; Kashimata, R.; Sasaki, R.; Kumagai, M.; Yagishita-Kyo, N.; Awaji, T.; Murakami, T.; Mizuno, Y.; Nakano, M.; Takahashi, T.; Takeuchi, H.; Honke, K.
10.1101/2025.06.18.660084 — microbiology — Posted on 2025-06-20
1111 Tau-seed interactome analysis reveals distinct functional signatures in Alzheimer's disease across model systems.
Martinez, P.; Patel, H.; You, Y.; Lopes, D.; Amaro, A.; Jury-Garfe, N.; Min, Y.; Redding-Ochoa, J.; Dutta, S.; Rochet, C.; Ertekin-Taner, N.; Troncoso, J.; Lasagna-Reeves, C. A.
10.1101/2025.06.17.660179 — neuroscience — Posted on 2025-06-20
1114 Foundation Model Attributions Reveal Shared Inflammatory Program Across Diseases
Gold, M. P.; Reyes, M.; Diamant, N.; Kuo, T.; Hajiramezanali, E.; Newburger, J. W.; Son, M. B. F.; Lee, P. Y.; Scalia, G.; BenTaieb, A.; Kapadia, S. B.; Tripathi, A.; Corrada Bravo, H.; Heimberg, G.; Biancalani, T.
10.1101/2025.06.14.659567 — bioinformatics — Posted on 2025-06-20
1115 Integrated Microfluidic Platform for High-Throughput Generation of Intestinal Organoids in Hydrogel Droplets
Lavickova, B.; Kronabitter, H. T.; Cervera-Negueruela, M.; Ceylan, E.; Benito-Zarza, L.; Cubela, I.; Lopez-Sandoval, R.; Camp, G.; Garcia-Cordero, J. L.
10.1101/2025.06.14.659486 — bioengineering — Posted on 2025-06-20
1116 Identification of High Blanchability Donors, Candidate genes and Markers in Groundnut
Shah, P.; Gangurde, S. S.; Senthil, R.; Singh, K.; Singham, P.; Pasupuleti, J.; Mayes, S.; Pandey, M. K.
10.1101/2025.06.18.660288 — genomics — Posted on 2025-06-20
1117 CDKN1A (p21Cip/Waf1) stabilizes Cyclin D3 by inhibiting its phosphorylation-dependent nuclear export following butyrate treatment
Ghrib, M. A.; Dayhoff, G. W.; Chahtour, C.; Rodrigues-Machado, C.; Youssef, A.; Schillaci, G.; Gautreau, G.; Henry, C.; Uversky, V. N.; Rigolet, P.; Blottiere, H. M.; Lelievre, J.-M.
10.1101/2025.06.19.660543 — cell biology — Posted on 2025-06-20
1121 How Varenicline Works: Identifying Critical Receptor and Ligand-based Interactions
Aiken, S. G.; Fiorito, D.; Harper, M.; Pikus, G.; Underhill, J.; Murray, J.; Rawlinson, J.; O'Donoghue, A. C.; Gotti, C.; Lummis, S.; Minguez Vinas, T.; Viscarra, F.; Bermudez, I.; Gallagher, T.; Oliveira, A. S. F.
10.1101/2025.06.14.659675 — pharmacology and toxicology — Posted on 2025-06-20
1129 OmicsSankey: Crossing Reduction of Sankey Diagram on Omics Data
Li, S.; Tan, B.; Ouyang, S.; Ling, Z.; Huo, M.; Shen, T.; WANG, j.; Feng, X.
10.1101/2025.06.13.659656 — bioinformatics — Posted on 2025-06-20
1130 PLAID: ultrafast single-sample gene set enrichment scoring
Zito, A.; Escriba-Montagut, X.; Scorici, G.; Martinelli, A.; Akhmedov, M.; Kwee, I.
10.1101/2025.06.14.659661 — bioinformatics — Posted on 2025-06-20
1131 YAP signaling promotes resistance to MEK and AKT inhibition in NF1-related MPNSTs
McGee, L. E.; Grit, J. L.; Essenburg, C. J.; Agrusa, S.; Turner, L.; Becker, K.; Dey, A.; Klomp, J. E.; Klomp, J. A.; Adams, M.; Beddows, I.; Wolfrum, E.; Fu, D.; Hirbe, A. C.; Graveel, C. R.; Steensma, M. R.
10.1101/2025.06.16.659334 — cancer biology — Posted on 2025-06-20
1132 Gastric cancer treatment target identified from an accelerated Helicobacter-induced gastric cancer mouse model
Kurstjens, E. M.; Cox, K.; Bali, P.; Amirfakhri, S.; Hernandez, J.; Lozano-Pope, I.; Benner, C.; Bouvet, M.; Obonyo, M.
10.1101/2025.06.14.659641 — cancer biology — Posted on 2025-06-20
1133 De novo proteins integrate cellular systems using ancient protein targeting and degradation pathways
Houghton, C. J.; Castilho Coelho, N.; Chiang, A.; Hedayati, S.; Parikh, S. B.; Ozbaki-Yagan, N.; Wacholder, A.; Iannotta, J.; Berger, A.; Wohlever, M. L.; Carvunis, A.-R.; O'Donnell, A. F.
10.1101/2024.08.28.610198 — evolutionary biology — Posted on 2025-06-20
1134 Global analysis of cancer cell responses to USP9X inhibition
Schenk, P.; Devine, S. M.; Cobbold, S. A.; Ang, C.-S.; Geoghegan, N. D.; Calleja, D. J.; Multari, D. H.; Vaibhav, V.; Lu, B. G. C.; Klemm, T. A.; Dagley, L. F.; Lowes, K. N.; Williamson, N.; Eichhorn, P. J. A.; Ng, A. P.; Feltham, R.; Komander, D.
10.1101/2025.06.18.660475 — cell biology — Posted on 2025-06-20
1136 Heme drives cardiac endothelial senescence in sepsis via STING activation
Li, T.; Zhu, P.; Zhang, T.; Adams, J.; Tu, F.; Garbe, C.; Zhang, X.; Liu, L.; Singh, K.; Williams, D.; Li, C.; Wang, X.
10.1101/2025.06.18.660159 — cell biology — Posted on 2025-06-20
1137 Intrinsically Disordered Regions Form Nucleoli and Cajal Bodies While Fostering RNA Modification
Meznad, K.; Deogharia, M.; Wacheul, L.; Zorbas, C.; Lafontaine, D. L.; Meier, U. T.
10.1101/2025.06.18.660405 — cell biology — Posted on 2025-06-20
1141 Chromatin remodeling with combined FACT and BET inhibition disrupts oncogenic transcription in Diffuse Midline Glioma
Holliday, H.; Khan, A.; Ehteda, A.; Nguyen, H.; Ross, S. E.; Jayatilleke, N.; Gopalakrishnan, A.; Wang, E.; Colino Sanguino, Y.; Kavanagh, D.; Guo, X.; Liu, J.; Lawrence, D.; Sun, C. X.; Lehmann, R.; Ip, C. K.; Lee, A.; Rangel-Sanchez, L.; Li, W.; Salomon, R.; Firestein, R.; Weatheritt, R. J.; Valdes-Mora, F.; Dinger, M. E.; Phoenix, T. N.; Mayoh, C.; Rayner, B. S.; Tsoli, M.; Ziegler, D. S.
10.1101/2024.06.06.597703 — cancer biology — Posted on 2025-06-20
1142 Reprogramming of Cellular Plasticity via ETS and MYC Core-regulatory Circuits During Response to MAPK Inhibition in BRAF-mutant Colorectal Cancer
Lee, H. M.; Zheng, Z.; Sorokin, A.; Wong, C. W.; Napolitano, S.; Chowdhury, S.; Kanikarla, P. M.; Singh, A. K.; Kochat, V.; Bristow, C. A.; Srinivasan, S.; Peoples, M.; Arslan, E.; Alshenaifi, J. Y.; Villarreal, O. E.; Morris, V. K.; Shen, J. P.; Meric-Bernstam, F.; Jain, A. K.; Fowlkes, N. W.; Anderson, A.; Menter, D. G.; Saw, A. K.; Rai, K.; Kopetz, S.
10.1101/2025.06.15.659716 — cancer biology — Posted on 2025-06-20
1143 Mechanisms of resistance to VHL loss-induced genetic and pharmacological vulnerabilities
Ge, J.; Hirosue, S.; Patel, S. A.; Wesolowski, L.; Dyas, A.; Yong, C.; Castillon, L.; de Haan, S.; Drost, J.; Stewart, G. D.; Obenauf, A.; Munoz-Espin, D.; Vanharanta, S.
10.1101/2025.06.14.659649 — cancer biology — Posted on 2025-06-20
1145 Multimodal Validation of the Existence of Transitional Cerebellar Progenitors in the Human Fetal Cerebellum
Luo, Z.; Xia, M.; Zhang, F.; Xin, D.; Rao, R.; Kiang, K.; Berry, K.; Xiong, Y.; Liu, H.; Lin, Y.; Hu, M.; Xin, M.; Ma, J.; Li, H.; Taylor, M. D.; Zhou, W.; Lu, Q. R.
10.1101/2025.06.01.657310 — developmental biology — Posted on 2025-06-20
1146 Biome-specific genome catalogues reveal functional potential of shallow sequencing
Escobar-Zepeda, A.; Ruuskanen, M. O.; Beracochea, M.; Lu, J.; Mongad, D.; Richardson, L.; Finn, R. D.; Lahti, L.
10.1101/2025.06.16.659887 — bioinformatics — Posted on 2025-06-20
1148 CPT1B-Mediated Fatty Acid Oxidation Induces Pigmentation in Solar Lentigo
Choi, Y.; Nam, U.; Kim, J.; Yoon, S.-Y.; Lee, N.; Cho, H.; Kim, S.; Yu, S.; Kim, J.; Moon, H.-N.; Lew, B.-L.; Lee, Y.; Kim, M. S.; Kwon, S.-H.
10.1101/2025.06.15.659823 — systems biology — Posted on 2025-06-19
1150 Safeguarding evolutionary history in a biodiversity hotspot: downscaling the EDGE metric to a regional application
Ramos-Gutierrez, I.; Pipins, S.; Molina-Venegas, R.; Fernandez-Mazuecos, M.; Mejias, P. J.; Moreno-Saiz, J. C.; Forest, F.
10.1101/2025.06.16.659859 — plant biology — Posted on 2025-06-19
1151 APOE4 drives widespread changes to the hepatic proteome and alters metabolic function
Lysaker, C.; Johnson, C.; Csikos, V.; Franczak, E.; Benson, M.; Thyfault, J.; Geiger, P.; Morris, J.; Wilkins, H.
10.1101/2025.06.15.659815 — physiology — Posted on 2025-06-19
1154 Small uncultured viral-like entities redraw the origin of viruses and cellular compartments
Aguilar, A.; Miranda, I.; Nadel, O.; Nayfach, S.; Segall, A.; Rohwer, F.; Roux, S.; White, S.; Luque, A.
10.1101/2025.06.18.659913 — bioinformatics — Posted on 2025-06-19
1157 Signatures of selection and mechanisms of insecticide resistance in Ugandan Anopheles funestus: Insights from embedding translational genomics into the LLINEUP cluster randomised trial.
Kayondo, L. N.; Nagi, S. C.; Njoroge, H.; Hernandez-Koutoucheva, A.; McDermott, D. P.; Gonahasa, S.; Lynd, A. R.; Oruni, A.; Sebuguzi, C. M.; Opigo, J.; Yeka, A.; Katureebe, A.; Kyohere, M.; Kamya, M.; Dorsey, G.; Hemingway, J.; Staedke, S. G.; Sam, N.; Nankabirwa, J.; Kayondo, J.; Clarkson, C. S.; Miles, A.; Lawniczak, M. K. N.; Lucas, E. R.; Donnelly, M. J.
10.1101/2025.06.17.659961 — genomics — Posted on 2025-06-19
1158 Coral genetic structure in the Western Indian Ocean mirrors ocean circulation and thermal stress
Guillaume, A. S.; Joost, S.; Curpen, S.; Dumur Neelayya, D.; Harree-Somah, L.; Sadasing, O.; Saponari, L.; Dale, C.; Barret, L.; Andrews, N.; Poretti, M.; Berteaux-Lecellier, V.; Lecellier, G.; Selmoni, O.
10.1101/2025.06.16.659828 — evolutionary biology — Posted on 2025-06-19
1159 The evolution of gene regulatory programs controlling gonadal development in primates
Trost, N.; Fallahshahroudi, A.; Sarropoulos, I.; Schneider, C.; Schmidt, J.; Mbengue, N.; Wolff, E.; Drummer, C.; Frömel, R.; Lisgo, S.; Murat, F.; Sepp, M.; Cardoso-Moreira, M.; Behr, R.; Kaessmann, H.
10.1101/2025.06.17.659946 — evolutionary biology — Posted on 2025-06-19
1160 Redox robustness drives LPMO evolution
Ayuso-Fernandez, I.; Emrich-Mills, T. Z.; Golten, O.; Forsberg, Z.; Hall, K. R.; Nagy, L. G.; Sorlie, M.; Rohr, A. K.; Eijsink, V. G. H.
10.1101/2025.06.16.659879 — evolutionary biology — Posted on 2025-06-19
1163 Plant sexual and asexual contributions to the seed microbiome
Faticov, M.; Tack, A. J. M.; Ortner, D.; Berg, G.; Abdelfattah, A.
10.1101/2025.06.16.659819 — ecology — Posted on 2025-06-19
1164 Gradual ontogenetic shifts in the mobility and space use of long-lived migratory greater flamingos
Lopez-Ricaurte, L.; Vansteelant, W. M. G.; Antoine, A.; Duriez, O.; Jiguet, F.; Nissardi, S.; Scridel, D.; Serra, L.; Tillo, S.; Bechet, A.; Champagnon, J.
10.1101/2025.06.16.659883 — ecology — Posted on 2025-06-19
1165 Predators at the Viral Gate: Multi-Species Foraging at a Marburg Virus Reservoir
Atukwatse, B.; Cornille, O.; Muhereza, J.; Nsabimana, W.; Ssemakula, Y.; Braczkowski, A. A.
10.1101/2025.06.16.659814 — ecology — Posted on 2025-06-19
1169 Metabolite-based genome-wide association studies enable the dissection of the genetic bases of bioactive compounds in Chickpea seeds
Ruan, S.; Rocchetti, L.; Bitocch, E.; Wendenburg, R.; Santamarina, C.; Di Vittori, V.; Istanbuli, T.; Hamwieh, A.; Fernie, A. R.; Papa, R.; Alseekh, S.
10.1101/2025.06.16.659862 — plant biology — Posted on 2025-06-19
1170 An Integrative Approach to Develop and Characterise Antibodies Against the Cancer Associated Antigen Sialyl Lewis A (CA 19-9)
Freitag, A.; Khilji, S. K.; Nedielkov, R.; Kumar, S. M.; Krummhaar, M.; Arndt, J.; Moreira, G. S. G.; Luehle, J.; Goerdeler, F.; Kamphues, C.; Roth, C.; Mroginski, M.-A.; Seeberger, P.; Moeller, H. M.; Moscovitz, O.
10.1101/2025.06.15.659274 — cancer biology — Posted on 2025-06-19
1172 PathoEye: a deep learning framework for the whole-slide image analysis of skin tissue
Lin, Y.; Lin, F.; Zhang, Y.; Wen, J.; Li, G.; Zeng, X.; Sun, H.; Jiang, H.; Yan, T.; Xue, R.; Sun, H.; Yang, B.; Zhou, J.
10.1101/2025.06.16.659818 — bioinformatics — Posted on 2025-06-19
1173 Predicting Spatial Transcriptomics from H&E Image by Pretrained Contrastive Alignment Learning
Zou, J.; Xiao, K.; Chen, Z.; Pei, J.; Xu, J.; Chen, T.; Hou, L.; Wu, C.; She, Y.; Yuan, Z.; Chen, L.
10.1101/2025.06.15.659438 — bioinformatics — Posted on 2025-06-19
1174 LadybirdBase: a comprehensive biology, ecology and omics resource for ladybird beetles (Coccinellidae)
Sun, Y.-F.; Yang, K.-Y.; Li, H.; Liang, Y.-S.; Cai, L.-Q.; Xie, J.-Y.; Zhang, Y.-W.; Liang, J.-Y.; Mou, Q.; Wang, Y.-M.; Chen, D.; Qi, M.-X.; Carlos Ramos Aguila, L.; Li, H.-S.; Pang, H.
10.1101/2025.06.15.659824 — bioinformatics — Posted on 2025-06-19
1176 Analytical model of the selective cutting mechanism used by ovipositors of sawflies
Verdaguer Mallorqui, M.; Vincent, J. F. V.; Liston, A.; Blagoderov, V.; Desmulliez, M. P. Y.
10.1101/2025.06.15.659745 — bioengineering — Posted on 2025-06-19
1177 Real-Time Human Interaction with Virtual Swarms in Shared Physical Space
Mezey, D.; Bartashevich, P.; Hasbani, G. E.; Romanczuk, P.; Hamann, H.; Deffner, D.; James, D.
10.1101/2025.06.15.659521 — animal behavior and cognition — Posted on 2025-06-19
1178 One Sea, Different Whales: Genomics Sheds Light on a Small Population of Fin Whales
Biello, R.; Iannucci, A.; Fuselli, S.; Desiato, E.; Urban R., J.; Fossi, M. C.; Panti, C.; Mancia, A.
10.1101/2025.06.16.659691 — genomics — Posted on 2025-06-19
1180 Intracellular glutamine fluctuates with nitrogen availability and regulates Mycobacterium smegmatis biofilm formation
Varner, E.; Meyer, M. D.; Whalen, J.; Wang, Y.-H.; Rodriguez, C.; Malik, I.; Mullet, S. J.; Gelhaus, S. L.; DePas, W. H.
10.1101/2025.06.18.660496 — microbiology — Posted on 2025-06-19
1181 Dynamic changes to the plastoglobule lipidome and proteome in heat-stressed maize
Devadasu, E.; Susanto, F. A.; Schilmiller, A. L.; Johnny, C.; Lundquist, P. K.
10.1101/2025.06.13.659543 — plant biology — Posted on 2025-06-19
1183 Microbial diversity of Atlantic Rainforest ponds assessed by nanopore sequencing
Atum, S. V.; Soares, D. M.; Santos, I.; Johnson, G. A.; Domingos, A. H.; Bechara, E. J.; Setubal, J. C.; Urban, L.; Stevani, C. V.; Freire, R. S.
10.1101/2025.06.17.660208 — bioinformatics — Posted on 2025-06-19
1187 Role of Uba7-UFD in E1-E2 ISGylation: NMR-Based Insights into E2 Binding Dynamics
Dag, C.; Kazar, A. E.; Kahraman, K.; Gocenler, O.; Lee, W.; Lambert, M.; Tozkoparan Ceylan, C. D.; Shim, J. G.; Haas, A. L.; Dotsch, V.; Ziarek, J. J.; Elgin, E. S.
10.1101/2025.06.14.659664 — biochemistry — Posted on 2025-06-19
1188 Intrinsically disordered bHLH family member TCF4 drives LLPS in a DNA-dependent manner
Sozanska, N.; Klepka, B. P.; Niedzwiecka, A.; Greb-Markiewicz, B. P.; Ozyhar, A.; Tarczewska, A.
10.1101/2025.06.18.660356 — biochemistry — Posted on 2025-06-19
1189 A cell-based degrader assessment platform facilitates discovery of functional NUDT5 PROTACs
Alam, S.; Pires, M. J.; Tidestav, G.; Jemth, A.-S.; Eklund, J.; Klingegard, F.; Caraballo, R.; Gaetani, M.; Rotili, D.; van den Elzen, S.; van Berkum, E.; Wallner, O.; Malmström, J.; Arvidsson, P. I.; Valerie, N. C. K.; Altun, M.
10.1101/2025.06.13.659494 — biochemistry — Posted on 2025-06-19
1190 MTBP allosterically activates Cdk8-CycC kinase activity
Zaffar, E.; vieyto, J.; Pravi, K.; Aslam, M. F.; Almeida, Y.; Perez, J. M.; Kaschani, F.; Kaiser, M.; Kroesen, A.; Boos, D.; Garcia, E. S.
10.1101/2025.06.16.659917 — biochemistry — Posted on 2025-06-19
1191 Peptides at vesicle and mineral prebiotic interfaces
Cherepashuk, I.; Makarov, M.; Soucek, R.; Krystufek, R.; Hadravova, R.; Giacobelli, V. G.; Longo, L. M.; Fujishima, K.; Jordan, S. F.; Hlouchova, K.
10.1101/2025.06.13.659467 — evolutionary biology — Posted on 2025-06-19
1197 A new role for lipoproteins LpqZ and FecB in orchestrating mycobacterial cell envelope biogenesis
Lissner, R.; Franklin, A.; Benedict, S.; Charitou, V.; Speer, A.; Knol, J.; Jimenez, C.; Moynihan, P.; Nejentsev, S.; Kuijl, C.; Bitter, W.
10.1101/2025.06.19.660376 — microbiology — Posted on 2025-06-19
1198 Linear scaling reveals low-dimensional structure in observable microbial dynamics
Zhou, Z.; Chen, X.; Simsek, E.; Hamrick, G. S.; Baig, Y.; Holmes, Z. A.; Du, Z.; Karig, D. K.; You, L.
10.1101/2025.06.13.659614 — systems biology — Posted on 2025-06-19
1201 MeCP2 requires interactions with nucleosome linker DNA to read chromatin DNA methylation
Watson, J. A.; Alexander-Howden, B. K.; Hall, T. S.; Wear, M. A.; McGhie, F. A.; Clifford, G.; Wapenaar, H.; Zou, J.; Bird, A.; Wilson, M. D.
10.1101/2025.06.17.659564 — biochemistry — Posted on 2025-06-19
1202 Radiolabeling Isolated Mitochondria with Tc-99m: A First-in-Field Protocol and Early Feasibility Findings
Walker, M.; Miralles, F.; Prijoles, K. L.; Kazmi, J.; Hough, J.; Lewis, D. H.; Levitt, M.; Sancak, Y.
10.1101/2025.06.15.658690 — cell biology — Posted on 2025-06-19
1203 Discovery and characterization of cell-permeable inhibitors of Leishmania mexicana CLK1 using an in-cell target engagement assay
Catta-Preta, C. M. C.; Ramos, P. Z.; Carnielli, J. B. T.; Vasconcelos, S. N. S.; Dowle, A.; Fanti, R. C.; dos Reis, C. V.; Coelho, A. C.; Massirer, K. B.; Mottram, J. C.; Counago, R. M.
10.1101/2025.06.17.659316 — cell biology — Posted on 2025-06-19
1204 Host- and microbial-mediated mucin degradation differentially shape Pseudomonas aeruginosa physiology and gene expression
Arif, S. J.; Hoffman, K. M.; Flynn, J. M.; Wiggen, T. D.; Lucas, S. K.; Villarreal, A. R.; Gilbertsen, A. J.; Dunitz, J. M.; Hunter, R. C.
10.1101/2025.06.18.660398 — microbiology — Posted on 2025-06-19
1206 Sex bias determines MERS-CoV infection outcomes in a mouse model of differential pathogenicity
Habbick, M. R.; Bushmaker, T.; Singh, R.; Sharma, P.; Munster, V. J.; van Doremalen, N.; Rasmussen, A. L.
10.1101/2025.06.19.660369 — microbiology — Posted on 2025-06-19
1207 Biofilm development of Porphyromonas gingivalis on titanium surfaces in response to 1,4-dihydroxy-2-naphthoic acid - a hybrid in vitro - in silico approach
Szafranski, S. P.; Mukherjee, R.; Klempt, F.; Fuchs, F.; Doll-Nikutta, K.; Soleimani, M.; Wriggers, P.; Junker, P.; Stiesch, M.
10.1101/2025.06.19.660513 — microbiology — Posted on 2025-06-19
1209 The unique role of nucS-mediated non-canonical mismatch repair in Mycobacterium tuberculosis resistance evolution
Martin-Blecua, I.; Valverde, J. R.; Garcia-Bravo, P.; Ruiz-Enamorado, A.; Prados-Rosales, R.; Sastre-Dominguez, J.; Das, L.; Jacobs, W. R.; San Millan, A.; Blazquez, J.; Gullon, S.
10.1101/2025.06.19.660520 — microbiology — Posted on 2025-06-19
1215 Fibulin-4 is highly expressed in metastatic breast cancer and can serve as a target of peptide-based imaging probes and experimental therapeutics
Daquinag, A. C.; AghaAmiri, S.; Farmer, S. M.; Zhang, S.; Ghosh, S. C.; Vargas, S. H.; Ramesh, A. K.; An, Z.; Azhdarinia, A.; Kolonin, M. G.
10.1101/2025.06.18.657655 — cancer biology — Posted on 2025-06-19
1216 Interactive delineation and quantification of anatomical structure with virtual reality
Garkov, D.; Lein, E.; Kielkopf, N.; Dullin, C.; Klein, K.; Sommer, B.; Jordan, A. L.; Schreiber, F.
10.1101/2025.06.17.659041 — bioinformatics — Posted on 2025-06-19
1220 Carbon and nitrogen stable isotopic profiling of chimpanzees and other primate hairs in Kalinzu Forest Reserve, Uganda
Tsutaya, T.; Aruga, N.; Ishikawa, N. F.; Sasaki, Y.; Kitayama, H.; Yoneda, M.; Ogawa, N. O.; Ohkouchi, N.; Hashimoto, C.
10.1101/2025.06.15.658141 — ecology — Posted on 2025-06-19
1221 Parental exposure to wet and dry conditions shapes the viability and thermotolerance of eggs in Aedes aegypti
Chakraborty, S.; Shah, D.; Dayal, D.; Lutz, L.; Wang, L.; Garcia, J.; Lefevre, G.; Susanto, E.; Benoit, J. B.
10.1101/2025.06.16.658957 — physiology — Posted on 2025-06-19
1222 Orco regulates the circadian activity of pheromone-sensitive olfactory receptor neurons in hawkmoths
Vijayan, A.; Forlino, M.; Chang, Y.; Rojas, P.; Schroeder, K.; Schneider, A. C.; Garcia, M. E.; Stengl, M.
10.1101/2025.06.17.659282 — physiology — Posted on 2025-06-19
1223 MYC-induced oncogenesis is dependent on acidic patches within its N-terminal intrinsically disordered domain.
Llombart, V.; O'Connor, D.; Demeulemeester, J.; Bhamra, A.; Surinova, S.; Turna, A.; Fung, K.; Wang, L.; Li, Y.; Rapoz-D'Silva, T.; Ahmed, F.; Niskanen, H.; Stöppelkamp, I.; Hnisz, D.; Bottaro, S.; Fisicaro, C.; He, S.; Look, A. T.; Mansour, M. R.
10.1101/2025.06.16.659507 — cancer biology — Posted on 2025-06-19
1225 UniCure: A Foundation Model for Predicting Personalized Cancer Therapy Response
Chen, Z.; Tian, S.; Pei, J.; Gu, R.; Li, Y.; Ding, S.; Xu, Y.; Zheng, X.; Liu, M.; Du, X.; Zhu, J.; Zou, J.; Xu, J.; Jiang, W.; Chen, Y.; Dong, B.; Zhang, Q.; Ren, S.; Wang, S.; Wen, H.; Zhang, W.; Chen, L.
10.1101/2025.06.14.658531 — bioinformatics — Posted on 2025-06-19
1226 ZIPcnv: accurate and efficient inference of copy number variations from shallow whole-genome sequencing
Xue, Z.; Zeng, J.; Yuan, J.; Wang, T.; Lai, X.; Wang, L.; Wang, Y.; Zhu, H.; Jin, X.; Wang, J.
10.1101/2025.06.13.659496 — bioinformatics — Posted on 2025-06-19
1228 Monooxygenase-dehydrogenase cascade for sustained enzymatic remediation of TMA in salmon protein hydrolysates
Ree, R.; Larsen, O.; Gaykawad, S.; Ramanand, S. S.; Garcia-Moyano, A.; Chiriac, I. E.; Puntervoll, P.; Bjerga, G. E. K.
10.1101/2025.06.16.658034 — biochemistry — Posted on 2025-06-19
1230 Genotype-first approach revealed unrecognized breed-specific genetic diseases in dogs
Mizukami, K.; Yamada, R.; Toyoda, H.; Aoi, T.; Endo, M.; Kawasaki, J.; Nakashima, K.; Endo, T.; Watanabe, T.; Ikeda, N.; Honnami, M.; Fujita, N.; Nakagawa, T.; Nishimura, R.; Uchiyama, J.; Hisasue, M.; Tsujimoto, H.; Sakaguchi, M.; Tomiyasu, H.; Momozawa, Y.
10.1101/2025.06.16.659006 — genomics — Posted on 2025-06-19
1232 Evolution of opsin genes in closely-related species of butterflies specialized in different microhabitats.
Ledamoisel, J.; Dang, A.; Devilliers, J.; Marvillet, T.; Lemoine, S.; Lopez Villavicencio, M.; Briscoe, A. D.; Debat, V.; Llaurens, V.
10.1101/2025.06.13.659549 — evolutionary biology — Posted on 2025-06-19
1233 A general allometric rule predicts sustainable growth across societies
Angulo, M. T.; Michel-Mata, S.; Velasco-Hernandez, J. X.; Saavedra, S.; Marquet, P. A.
10.1101/2025.06.13.659593 — ecology — Posted on 2025-06-19
1234 Wildlife movement and contact responses to intensive culling: implications for disease control
Chalkowski, K.; Snow, N. P.; Feuka, A. B.; Leland, B. R.; VerCauteren, K. C.; Miller, R. S.; Pepin, K. M.
10.1101/2025.06.13.659516 — ecology — Posted on 2025-06-19
1235 Genome-wide analysis reveals mutual gene flow between goats from Island Southeast Asia and from Southern Africa
Masuko, R.; Ayin, A.; Masaoka, M.; Kawaguchi, F.; Sasazaki, S.; Dagong, M. I. A.; Bugiwati, S. R. A.; Masangkay, J. S.; Wu, J.; Yonezawa, T.; Lenstra, J. A.; Mannen, H.
10.1101/2025.06.13.659639 — ecology — Posted on 2025-06-19
1239 Genes govern metabolism-Enzymes define pathways and metabolic relationships
Zhan, J.; Jarrell, Z. R.; Kemp, M. L.; Weinberg, J.; Go, Y.-M. G.; Martin, G. S.; Jones, D. P.
10.1101/2025.06.16.657199 — systems biology — Posted on 2025-06-19
1240 Efficient genetic code expansion tools enable in vivo study of lysine acetylation in non-model bacteria
Van Fossen, E. M.; Stephenson, M.; Frank, A.; Akella, S.; Wooldridge, R.; Wilson, A.; You, Y.; Nakayasu, E.; Egbert, R.; Elmore, J. R.
10.1101/2025.04.14.648644 — synthetic biology — Posted on 2025-06-19
1243 MimicNeoAI: An integrated pipeline for identifying microbial mimicry antigens and tumor neoantigen partners
Chen, T.; Wang, W.; Zuo, X.; Zhang, Y.; Li, Z.; He, Y.; Ye, F.; Zhang, B.; Jiang, Q.; Liu, H.; Zhang, L.; Fang, J.; Zhang, Y.
10.1101/2025.06.13.658292 — bioinformatics — Posted on 2025-06-19
1246 Metabolic reprogramming in the spinal cord drives the transition to pain chronicity
Tagne, A. M.; Fotio, Y.; Lee, H.-L.; Jung, K.-M.; Katz, J.; Ahmed, F.; Le, J.; Bazinet, R.; Jang, C.; Piomelli, D.
10.1101/2025.01.30.635746 — neuroscience — Posted on 2025-06-19
1247 The Spatial Atlas of Human Anatomy (SAHA): A Multimodal Subcellular-Resolution Reference Across Human Organs
Park, J.; De Gregorio, R.; Hissong, E.; Ozcelik, E.; Bartelo, N.; Dezem, F. S.; Zhang, L.; Marcao, M.; DuBose, H.; Zheng, Y.; Abila, E.; Kim, J.; Proszynski, J.; Agyemang, A. A.; Arikatla, M. R.; Wani, A.; Liu, Y.; Metzger, E.; Rogers, S.; Divakar, P.; Dulai, P. S.; Reeves, J. W.; Liang, Y.; Pan, L.; Bhattacharjee, S.; Patrick, M.; Young, K.; Heck, A.; Korukonda, M.; McGuire, D.; Wu, L.; Wardhani, A.; Beechem, J.; Church, G.; Lipkin, S. M.; Patel, S.; Socciarelli, F.; Chandwani, R.; Monette, S.; Robinson, B.; Loda, M.; Elemento, O.; Martelotto, L.; Plummer, J. T.; Rendeiro, A. F.; Alonso, A.;
10.1101/2025.06.16.658716 — systems biology — Posted on 2025-06-19
1249 High-speed whole-brain imaging in Drosophila
Gauthey, W.; Lin, A.; Ahmed, O. M.; Leifer, A. M.; Murthy, M.; Thiberge, S.
10.1101/2025.06.18.660371 — neuroscience — Posted on 2025-06-19
1251 Resolving synaptic events using subsynaptically targeted GCaMP8 variants
Chen, J.; Lin, J.; He, K.; Wang, L.; Han, Y.; Qiu, C.; Dickman, D. K.
10.1101/2025.06.19.660577 — neuroscience — Posted on 2025-06-19
1253 Charged peptides enriched in aromatic residues decelerate condensate ageing driven by cross-β-sheet formation
Sanchez-Burgos, I.; Tejedor, A. R.; Castro, A.; Feito, A.; Collepardo-Guevara, R.; Rene Espinosa, J.
10.1101/2024.12.16.628676 — biophysics — Posted on 2025-06-19
1254 Characterization of spatial homogeneous regions in tissues with concordex
Jackson, K. C.; Booeshaghi, A. S.; Galvez-Merchan, A.; Moses, L.; Chari, T.; Kim, A.; Hosten-Mittermaier, O.; Pachter, L.
10.1101/2023.06.28.546949 — bioinformatics — Posted on 2025-06-19
1256 MHC-IIB disassortative mate choice in a genetically monogamous seabird
Thel, L.; Pineaux, M.; Ribeiro, L.; Danchin, E.; Whelan, S.; Hatch, S. A.; Blanchard, P.; Leclaire, S.
10.1101/2024.12.19.629314 — animal behavior and cognition — Posted on 2025-06-19
1257 SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling
Meng, F.; Kim, J. H.; Tsai, C.-R.; Steimle, J. D.; Wang, J.; Shi, Y.; Li, R. G.; Xie, B.; Deshmukh, V.; Li, X.; Martin, J. F.
10.1101/2023.11.30.569413 — cell biology — Posted on 2025-06-19
1258 A pathogenic CD4 T cell phenotype in experimental uveitis shares common features with other immune mediated inflammatory
Ward, A.; Bell, O. H.; Martinez-Robles, L. D.; Lait, P. J. P.; Chu, C. J.; Copland, D. A.; Dick, A. D.; Nicholson, L. B.
10.1101/2025.06.14.659471 — immunology — Posted on 2025-06-19
1259 Characterisation of the dual roles of senescent-like T cells that arise during healthy and unhealthy ageing
Garrod-Ketchely, C.; Callender, L. A.; Schroth, J.; Littlewood, K.; Carroll, E. C.; Tamsan, D.; Tsang, V. S.; Nessel, I.; Riddell, N. E.; Chain, B.; Harding, D.; Marelli-Berg, F. M.; Bystrom, J.; Pereira Da Costa, M.; Carrascal-Minino, A.; Keeling, G. P.; Pham, T. T.; Sunassee, K.; De Rosales, R. T.; Terry, S. Y.; Pattrick, M.; Sutcliffe, C.; Worthington, A.; Hood, G.; Finer, S.; Henson, S. M.
10.1101/2025.06.16.659752 — immunology — Posted on 2025-06-19
1260 In silico discovery of pathogenic PD-L1 nsSNVs with altered glycosylation and immunotherapy binding
Tan, K. W.; Chacko, A.-M.; Khare, S.; Verma, C.; Kannan, S.; Petersen, S.; Ong, J.; Tan, C.
10.1101/2025.06.17.660108 — bioinformatics — Posted on 2025-06-19
1264 Disease-associated programming of cell memory in glycogen storage disorder type 1a
Sprecher, U.; Dsouza, J.; Mishra, K.; Muchtar, N.; Shalev, O.; Eliassaf, A.; Morshina, A.; Miliano, A. C.; Mithieux, G.; Rajas, F.; Avraham, S.; Castellani, F. M.; Kaufman, H.; Bergman, Y.; Garti, N.; Garti, S.; Linial, M.; Anikster, Y.; Kakhlon, O.; Weil, M.
10.1101/2023.02.20.529109 — cell biology — Posted on 2025-06-19
1265 Methylome profiling of SetDB1 deficient ESCs reveals diverse epigenetic cross-talk during pluripotency
Bovee, N. G. P.; Hoogland, S. H. A.; Habibi, E.; Fröhlich, S.; Brinkman, A. B.; Mulder, K.; Jansen, J. H.; Lorincz, M.; Stunnenberg, H. G.; Marks, H.
10.1101/2025.06.18.660343 — molecular biology — Posted on 2025-06-19
1266 Q1020R in the spike proteins of MERS-CoV from Arabian camels and recent human cases confers resistance against soluble human DPP4
Chen, N.; Kleine-Weber, H.; Alkharsah, K. R.; Winkler, M.; Volz, A.; Muller, M.; Corman, V. M.; Drosten, C.; Hoffmann, M.; Pohlmann, S. H.
10.1101/2025.06.17.660103 — microbiology — Posted on 2025-06-19
1269 Explaining tip-of-the-tongue experiences in older adults: how cardiorespiratory fitness is associated with mechanisms of brain function, structure, and perfusion
Rahman, F.; Tsvetanov, K. A.; Feron, J.; Mullinger, K.; Joyce, K.; Gilani, A.; Fernandes, E. G.; Wetterlin, A.; Wheeldon, L. R.; Lucas, S. J. E.; Segaert, K.
10.1101/2023.12.08.570799 — neuroscience — Posted on 2025-06-19
1270 How did evolution halve genome size during an oceanic island colonization?
Pisarenco, V. A.; Boada-Figueras, A.; Olive-Muniz, M.; Escuer, P.; Macias-Hernandez, N.; Arnedo, M. A.; Librado, P.; Sanchez-Gracia, A.; Guirao-Rico, S.; Rozas, J.
10.1101/2025.06.14.659697 — genomics — Posted on 2025-06-19
1272 Chiari II brain malformation is secondary to open spina bifida
Clark, M.; Edwards, T. J.; Savery, D.; Galea, G. L.; Samy, N.; Pauws, E.; Kessaris, N.; Greene, N. D.; Copp, A. J.
10.1101/2025.01.06.631442 — developmental biology — Posted on 2025-06-19
1273 The sequence and structural integrity of the SARS-CoV-2 Spike protein transmembrane domain is crucial for viral entry
Ortiz-Mateu, J.; Belda, D.; Aviles-Alia, A. I.; Alonso-Romero, J.; Garcia-Murria, M. J.; Mingarro, I.; Geller, R.; Martinez-Gil, L.
10.1101/2024.11.19.624333 — molecular biology — Posted on 2025-06-19
1275 Identification of a Highly Functional Effector CD8+ T Cell Program After Transplantation in Mice and Humans
Cohen, G. S.; Freibaum, J. S.; Leathem, R. P.; Shirkey, M. W.; Welsh, R. A.; Hatano, R.; Morimoto, C.; Cihakova, D.; Oh, B. C.; Bromberg, J. S.; Krummey, S. M.
10.1101/2024.11.26.625263 — immunology — Posted on 2025-06-19
1278 F2,6BP restores mitochondrial genome integrity in Huntingtons Disease
Chakraborty, A.; Mandal, S. M.; Mankevich, M.; Shahabi, S.; Biswas, T.; Mani, R. S.; Sreenivasmurthy, S. G.; Kodavati, M.; Tapryal, N.; Weinfeld, M.; Hegde, M.; Krishnan, B.; Ghosh, G.; Hazra, T.
10.1101/2024.11.04.621834 — neuroscience — Posted on 2025-06-19
1279 "Smurf Mice": revolutionising our understanding of age-related and end-of-life animal physiology
Cansell, C.; Goepp, V.; Bain, F.; Todd, N.; Douard, V.; Monnoye, M.; Zane, F.; Sanchez, C.; Pietrancosta, N.; ROVERE, C.; Denis, R.; Luquet, S.; Rera, M.
10.1101/2025.06.14.659669 — physiology — Posted on 2025-06-19
1283 A computational analysis of the glycoprotein LRP1 structure and the role of glycans as quaternary glue
Tuveri, G. M.; Basile, M.; Acosta Gutierrez, S.; Kausas, M.; Pujals, S.; Tian, X.; Franzese, G.; Ruiz Perez, L.; Battaglia, G.
10.1101/2025.06.10.658798 — biophysics — Posted on 2025-06-19
1286 Unique territorial and compartmental organization of chromosomes in the holocentric silkworm
Gil, J.; Navarrete, E.; Hockens, C.; Chowdhury, N.; Abraham, S.; Cornilleau, G.; Lei, E. P.; Mozziconacci, J.; Banigan, E. J.; Mirny, L. A.; Rosin, L. F.; Muller, H.; Drinnenberg, I. A.
10.1101/2023.09.14.557757 — genomics — Posted on 2025-06-19
1289 A unified rodent atlas reveals the cellular complexity and evolutionary divergence of the dorsal vagal complex
Hes, C.; Tomlinson, A. J.; Michielsen, L.; Murdoch, H. J.; Soltani, F.; Kokoeva, M.; Sabatini, P. V.
10.1101/2024.09.19.613879 — neuroscience — Posted on 2025-06-19
1290 Identification and optimization of trans-species reactive TfR1-binding VHH as tools for drug delivery across the blood brain barrier
David, M.; Cohen, R.; Beuzelin, D.; Ferracci, G.; Cresci, M.; Faucon, A.; Abouzid, K.; Godefroy, G.; Masse, M.; Mechioukhi, Y.; Girard, S. D.; Julien-Gau, I.; Boursery, C.; Fraisier, C.; Varini, K.; Thomas, M.; Jacquot, G.; Lecorche, P.; Serrano, B.; Romette, A.; Dangla Pelissier, G.; Godard, M.; Saillant, V.; Pruvost, T.; Sierocki, R.; Chames, P.; Kerfelec, B.; Temsamani, J.; KHRESTCHATISKY, M.
10.1101/2025.05.23.649291 — neuroscience — Posted on 2025-06-19
1291 Connectomic and behavioral alterations in creatine transporter deficiency are partially normalized by gene therapy
Montani, C.; Iovino, L.; Di Vetta, F.; Pasquin Mariani, J.-C. R.; de Guzman, A. E.; Gini, S.; Galbusera, A.; D'Epifanio, B.; Ghirardini, E.; Cornuti, S.; Dada, L.; Putignano, E.; Alessandri, M. G.; Mandrup Bertozzi, S.; Armirotti, A.; Baroncelli, L.; Gozzi, A.
10.1101/2024.01.12.575377 — neuroscience — Posted on 2025-06-19
1295 Xylazine and fentanyl co-administration delays wound healing in mice
Bedard, M. L.; Seim, R. F.; Brown, A. R.; Cline, C. A.; Gilley, K. R.; Wykoff, L. A.; Huffstickler, M.; Nakkala, P. B.; Rausser, S.; Dasgupta, N.; Strickland, J. C.; Coleman, L. G.; McElligott, Z. A.
10.1101/2025.06.18.660449 — pharmacology and toxicology — Posted on 2025-06-19
1297 Structural and functional characterisation of isolated puff adder (B. arietans) serine proteases
Wilkinson, M. C.; Modahl, C.; Saviola, A.; Tianyi, F.; Harrison, R. A.; Casewell, N. R.
10.1101/2025.06.11.659063 — biochemistry — Posted on 2025-06-19
1302 Mealtime alters daily rhythm in nuclear O-GlcNAc proteome to regulate hepatic gene expression
Liu, X.; Cai, Y. D.; Hou, C.; Liu, X.; Luo, Y.; Mendiola, A. J. P.; Xu, X.; Luo, Y.; Zheng, H.; Zhao, C.; Chen, C.-H.; Zhang, Y.; Xiang, Y.; Ma, J.; Chiu, J. C.
10.1101/2024.06.13.598946 — physiology — Posted on 2025-06-19
1304 Comparative microbiome analyses reveal differences between wild populations and captive groups of the Montseny Brook Newt (Calotriton arnoldi)
Tulloch, S. A.; Estarellas, M.; Adams, D. C.; Bonacolta, A.; Pagone, V.; Fernandez-Guiberteau, D.; Amat, F.; Montori, A.; Carbonell, F.; Obon, E.; Alonso, M.; Santmartin, M.; Xarles, J.; Marsol, R.; Guinart, D.; Solorzano, S.; Talavera, A.; Burriel-Carranza, B.; Bosch, E.; del Campo, J.; Carranza, S.
10.1101/2025.06.18.660306 — microbiology — Posted on 2025-06-18
1311 ZNF865 (BLST) Regulates Human Cell Senescence and DNA Damage
Lewis, C.; Levis, H.; Holbrook, J.; Polaski, J. T.; Jacobsen, T. D.; Gullbrand, S. E.; Diekman, B. O.; Iatridis, J. C.; Gertz, J.; Lawrence, B.; Bowles, R. D.
10.1101/2025.06.13.659603 — bioengineering — Posted on 2025-06-18
1312 Pseudouridine residues as substrates for serum ribonucleases
Gutierrez, C. S.; Silkenath, B.; Kojasoy, V.; Pich, J. A.; Lim, D. C.; Raines, R. T.
10.1101/2025.06.18.660232 — biochemistry — Posted on 2025-06-18
1313 CP12 controls ribulose 1,5 bisphosphate recycling and carbon acquisition in Chlamydomonas reinhardtii
Gerard, C.; Lebrun, R.; Verthuy, C.; Le Guenno, H.; Kosta, A.; Guerard, F.; Chang, K. S.; Avilan, L.; Gakiere, B.; Jin, E.; Maberly, S. C.; Gontero, B.; Launay, H.
10.1101/2025.06.13.659560 — biochemistry — Posted on 2025-06-18
1316 In mitochondrial disease respiratory complex III2 assembles complex I via toxic intermediate
Ayala-Hernandez, M. G.; Torales, A. B.; Tan, H. C.; Montgomery, C. B.; Padavannil, A.; Cortopassi, G.; Letts, J. A.
10.1101/2025.06.17.660237 — biochemistry — Posted on 2025-06-18
1317 Integrative structural interactomics reveals protein organization and structure in a giant virus
Muehlberg, L.; Ruta, J.; Mikirtumov, V.; Burton-Smith, R. N.; Murata, K.; Kudryashev, M.; Okamoto, K.; Bogdanow, B.; Liu, F.
10.1101/2025.06.16.659922 — biochemistry — Posted on 2025-06-18
1320 Spatially structured host genetic diversity leads to the evolution of local specialization
Visher, E.; Ali, A.; Barajas, J.; Masud, S.; McBride, A.; Ramos, E.; Sui, M.; Villalobos-Heredia, C.; Walzer, N.; White, P. S.; Boots, M.
10.1101/2023.05.12.540593 — evolutionary biology — Posted on 2025-06-18
1321 Modeling Adeno-Associated Viral Vector 6-mediated In Vivo Gene Delivery to Expanded Non-Mobilized Haemopoietic Stem Cells from Transfusion dependent Thalassemia Patients in a Humanized Mouse
Ramesh, J.; Kandasamy, K.; Yusof, N. N.; Sujuandy, I.; Keng, C. T.; Chen, L.; Chia, B. S.; Liu, M.; Her, Z.; Kukumberg, M.; Sia, K. C.; Mohd Rodhi, S. H.; Fu, Z. Y.; AJ, R.; Franco-Obregon, A.; Choolani, M.; Sesurajan, B. P.; Lai, P.-S.; Lee, S. Y.; Koh, P. L.; Chen, Q.; Gan, S.-U.; Chew, W. L.; Mattar, C. N.
10.1101/2025.06.17.659025 — molecular biology — Posted on 2025-06-18
1322 Intraspecific differences in habitat depth in a deep-sea isopod, Bathynomus doederleini (Crustacea: Isopoda: Cirolanidae), off the west coast of Kyushu, Japan
Anzai, S.; Tanaka, S.; Tsuchida, S.; Kato, R.; Azmi, S. S.; Izumi, S.; Maruyama, Y.; Hoshina, S.; Masumi, S.; Aizawa, I.; Uchida, J.; Kinoshita, T.; Yamawaki, N.; Aoshima, T.; Morii, Y.; Shimizu, K.; Yagi, M.
10.1101/2025.06.13.659626 — ecology — Posted on 2025-06-18
1325 Inhibitors of trehalose-6-phosphate synthase activity in fungal pathogens compromise thermal tolerance pathways
Miao, Y.; Yadav, V.; Shadrick, W.; Liu, J.; Jenner, A. R.; Nichols, C. B.; Gee, C.; Schäfer, M.; Tenor, J. L.; Perfect, J. R.; Lee, R. E.; Brennan, R. G.; Washington, E. J.
10.1101/2025.03.07.642065 — microbiology — Posted on 2025-06-18
1333 PGR5 is needed for redox-dependent regulation of ATP synthase both in chloroplasts and in cyanobacteria
Nikkanen, L.; Wey, L. T.; Woodford, R.; Mustila, H.; Kosmützky, D.; Ermakova, M.; Rintamäki, E.; Allahverdiyeva, Y.
10.1101/2024.11.03.621747 — plant biology — Posted on 2025-06-18
1334 Programmed downregulation of METTL3 is essential for decidualization in both humans and mice
Hong, Y.-Q.; Jiang, R.-F.; Tang, S.; Yang, X.-Q.; Zhang, M.; Liu, Y.; Zhang, Q.-Y.; Ding, C.-H.; Zheng, Z.-H.; Xu, Y.-W.; Yang, S.-H.; Liu, J.-L.
10.1101/2025.06.14.659666 — physiology — Posted on 2025-06-18
1335 Paracrine Action of Bone Morphogenetic Protein 3 in Pulmonary Arterial Hypertension
Halouani, A.; Mensah, E.; Athumani, Z.; Katz, M. G.; Jankowski, K.; Mansoori, M.; Rosen, V.; Ishikawa, K.; Hadri, L.; Sassi, Y.
10.1101/2025.06.13.659638 — pathology — Posted on 2025-06-18
1337 Tissue-specific consequences of tag fusions on protein expression in transgenic mice
Taylor, G. C.; Macdonald, L.; Szulc, N. A.; Gudauskaite, E.; Moran, B. H.; Brisbane, J. M.; Donald, M.; Taylor, E.; Zheng, D.; Gu, B.; Mill, P.; Yeyati, P. L.; Pokrzywa, W.; de Almeida, C. R.; Wood, A. J.
10.1101/2025.06.18.660429 — molecular biology — Posted on 2025-06-18
1338 Boltz-2: Towards Accurate and Efficient Binding Affinity Prediction
Passaro, S.; Corso, G.; Wohlwend, J.; Reveiz, M.; Thaler, S.; Ram Somnath, V.; Getz, N.; Portnoi, T.; Roy, J.; Stark, H.; Kwabi-Addo, D.; Beaini, D.; Jaakkola, T.; Barzilay, R.
10.1101/2025.06.14.659707 — molecular biology — Posted on 2025-06-18
1339 Inactivation of Influenza A Viruses (H1N1, H5N1) During Grana-Type Raw Milk Cheesemaking: Implications for Foodborne Transmission Risk
Moreno, A.; Pongolini, S.; Merialdi, G.; Cattoli, G.; Terregino, C.; Santini, N.; Benedetti, S.; Loli Piccolomini, L.; Padovani, A.; Rosamilia, A.; Alborali, G. L.; Daminelli, P.
10.1101/2025.06.18.660327 — microbiology — Posted on 2025-06-18
1341 Denitrification genes in SAR11 and other ubiquitous lineages of marine bacteria isolated from the northern Benguela Upwelling System
Morris, R. M.; Mattes, T. E.; Bubphamanee, K.; Sadler, M. C.; Calderaro, L. A.; Karolewski, J.; Casciotti, K. L.; Mason, O. U.
10.1101/2025.06.18.660415 — microbiology — Posted on 2025-06-18
1342 Pathogenicity and transmissibility of Monkeypox virus in dormice
Chen, Z.; Zhang, L.; Li, L.; Shao, M.; Zhao, Z.; Shang, C.; Liu, Z.; Liu, J.; Liu, Y.; Li, X.; Guo, Z.
10.1101/2025.06.17.660157 — microbiology — Posted on 2025-06-18
1344 Single administration of mosaic-8b RBD-nanoparticle vaccine prepared with atomic layer deposition technology elicits broadly neutralizing anti-sarbecovirus responses
Cohen, A. A.; Keeffe, J. A.; Rorick, A. V.; Rho, S.; Fils, A.-C. P.; Manasyan, L.; Gao, H.; Gnanapragasam, P. N. P.; Funke, H. H.; Randolph, T. W.; Garcea, R. L.; Bjorkman, P. J.
10.1101/2025.06.16.660007 — immunology — Posted on 2025-06-18
1347 AAV gene therapy for GBA-PD and Gaucher Disease
Ayloo, S.; Ryu, J.; Chou, S.-C.; Blatnik, L.; Wischhof, E.; Bu, J.; Guo, L.; Hossain, M.; Ghosh, D.; McCarty, W.; Bryne, A.; Chai, L.; Clarke, J.; Kayatekin, C.; Zhang, B.; Sardi, S. P.; Goulet, M.; Elmer, B.; Mueller, C.; Ramachandran, S.
10.1101/2025.06.17.660133 — neuroscience — Posted on 2025-06-18
1348 Yellow Fever Virus Interactomes Reveal Common and Divergent Strategies of Replication and Evolution for Mosquito-borne Flaviviruses
Kenaston, M. W.; Cherkashchenko, L.; Skawinski, C. L. S.; Fishburn, A. T.; Peddamallu, V.; Florio, C. J.; Robertson, A. E.; Bhattacharya, T.; Young, J. M.; Malik, H. S.; Shah, P. S.
10.1101/2025.06.14.659623 — systems biology — Posted on 2025-06-18
1350 Xylazine and fentanyl co-administration delays wound healing in mice
Bedard, M. L.; Seim, R. F.; Brown, A. R.; Cline, C. A.; Gilley, K. R.; Huffstickler, M.; Nakkala, P. B.; Rausser, S.; Dasgupta, N.; Strickland, J. C.; Coleman, L. G.; McElligott, Z. A.
10.1101/2025.06.18.660449 — pharmacology and toxicology — Posted on 2025-06-18
1351 Poldip2 deficiency attenuates disease severity in a mouse model of COVID-19
Hu, R.; Valdivia, A.; White, T.; Ju, W.; Brockman, M. L.; Zhang, Z.; Qu, H.; Gafford, G.; Joseph, G.; Burton, S.; Bassit, L.; Charles, T. P.; Levit, R. D.; Derdeyn, C. A.; Griendling, K. K.; Lassegue, B.; Hernandes, M. S.
10.1101/2025.06.17.657579 — pathology — Posted on 2025-06-18
1353 Neuronal SEL1L-HRD1 ERAD regulates one-carbon metabolism and is essential for motor function and survival
Torres, M.; Lu, Y.; Pederson, B.; Wang, H.; Gretzinger, A.; Lin, L.; Hwang, J.; Rupp, A.; Tomlinson, A.; Scott, A.; Zhao, Z.; Wahl, D.; Myers, M. G.; Lyssiotis, C. A.; Qi, L.
10.1101/2025.06.16.659938 — cell biology — Posted on 2025-06-18
1354 The Luminal Ring Protein C2CD3 Acts as a Radial In-to-Out Organizer of the Distal Centriole and Appendages
Bertiaux, E.; Louvel, V.; McCafferty, C.; van den Hoek, H.; Batman, U.; Mukherjee, S.; Bournonville, L.; Mercey, O.; Mean, I.; Mueller, A.; Van der Stappen, P.; Buss, G.; Daraspe, J.; Genoud, C.; Stearns, T.; Engel, B. D.; Hamel, V.; Guichard, P.
10.1101/2025.06.17.660204 — cell biology — Posted on 2025-06-18
1355 E2f coordinates the cell cycle and cell fate of hematopoietic progenitors to drive stress myelopoiesis
Viatour, P.; Cachon, A.; Crosier, G.; Kim, E.; Hayer, K.; Narravula, Y.; Hino, L.; Kjelstrom, S.; Tober, J.; Tan, K.; Speck, N. A.
10.1101/2025.06.16.659412 — cell biology — Posted on 2025-06-18
1356 Twinfilin is a potent uncapper of actin capping protein and modulates actomyosin contractility in the C. elegans spermatheca
Saini, A.; Kreizman, S.; Towsif, E.; Martinez-Lopez, J.; Maimon Zielonka, I.; Nitzan, A.; Rudnik, L.; Shekhar, S.; Zaidel-Bar, R.
10.1101/2025.06.17.660173 — cell biology — Posted on 2025-06-18
1357 The Mediator complex subunit Med19 extends healthy lifespan in Drosophila by preventing cellular and organismal frailty
Payet, A.; Guillou, E.; Bernat-Fabre, S.; Dromard-Berthezene, C.; Contreras, X.; Rivero, A.; Jullien, D.; BOURBON, H.-M.; FRENDO, J.-L.; Sengenes, C.; BOUBE, M.
10.1101/2025.06.18.659864 — cell biology — Posted on 2025-06-18
1360 ERM proteins regulate the shape and number of Endoplasmic Reticulum-Plasma Membrane Junctions in neurons
Deng, H.; Cheng, J.; Fetter, R. D.; Qin, G.; Zhang, J.; Liang, X.; Taylor, C.; Zhang, M.; Wu, X.; Shen, K.
10.1101/2025.06.18.660273 — cell biology — Posted on 2025-06-18
1361 FOXM1 Inhibition Promotes Polyploidization and Metabolic Maturation in Human iPSC-Derived Hepatocytes by Modulating the Wnt/β-Catenin Pathway
Telles-Silva, K. A.; Pacheco, L.; Komatsu, S.; Chianca, F.; Chagas, G.; Martins, G. C.; Gridina, M.; Panchenko, D.; Carvalho, V. M.; Caldini, E. G.; Fishman, V. S.; Arkin, M.; Goulart, E.; Zatz, M.
10.1101/2025.06.17.660221 — cell biology — Posted on 2025-06-18
1362 Long term trend and short-term dynamics of a willow grouse population
Willebrand, T.; Hornell-Willebrand, M.; Brittas, R.; Kleiven, E.
10.1101/2023.05.03.539219 — ecology — Posted on 2025-06-18
1365 An ERF transcription factor StPTI5, a novel regulator of endophyte community maintenance in potato
Lukan, T.; Kraigher, B.; Pogacar, K.; Stare, K.; Grubar Kovacic, T.; Zagorscak, M.; Petek, M.; Stefanic, P.; Vozelj, A.; Levak, V.; Mahkovec Povalej, T.; Garcia, J. M.; Pozo, M. J.; Mandic-Mulec, I.; Gruden, K.
10.1101/2025.04.24.650297 — plant biology — Posted on 2025-06-18
1367 Transparent transfer-free multilayer graphene microelectrodes enable high quality recordings in brain slices
Alvarez de Eulate, N.; Pavlou, C.; Leon Gonzalez, G.; Holzapfel, L.; Gao, Z.; Vollebregt, S.; Giagka, V.
10.1101/2025.06.13.657566 — bioengineering — Posted on 2025-06-18
1368 A computational model to study hemodynamics during atrial fibrillation
Plappert, F.; Oomen, P. J. A.; Jones, C. E.; Charitakis, E.; Karlsson, L. O.; Platonov, P. G.; Wallman, M.; Sandberg, F.
10.1101/2025.06.13.659399 — bioengineering — Posted on 2025-06-18
1369 Monitoring of vaccine targets and interventions using global genome data: vaccines.watch
David, S.; Abudahab, K.; Couto, N.; Daningrat, W. O. D.; Yeats, C.; Molloy, A.; Ashton, P. M.; Alikhan, N.-F.; Aanensen, D. M.; NIHR Global Health Research Unit on Genomics and enabling data for Surveillance of AMR,
10.1101/2025.06.13.659488 — genomics — Posted on 2025-06-18
1374 A Tunable Pulmonary Organoid Model Demonstrates Compositionally Driven Epithelial Plasticity and Immune Polarization
Edelstein, S. E.; Mizoguchi, S.; Gracia, M. T.; Wang, N.; Lee, V.; Kim, H.; Haynes, C.; Danelski, C.; Tsuchiya, T.; Sauler, M.; Raredon, M. S. B.
10.1101/2025.06.05.658120 — bioengineering — Posted on 2025-06-18
1377 In-depth analysis of the tear fluid glycoproteome reveals diverse lacritin glycosylation and spliceoforms
Chang, V.; Mahoney, K. E.; Lian, I.; Chen, R.; Chung, N.; Paaske Utheim, T.; Karlsson, N. G.; Malaker, S. A.
10.1101/2025.06.13.659589 — biochemistry — Posted on 2025-06-18
1380 POMT-dependent O-mannosylation regulates integrin β1 maturation via N-glycan processing
Alam, S.; Noor, S. I.; Hoffmann, M.; Lommel, M.; Thiel, C.; Rapp, E.; Strahl, S.
10.1101/2025.06.18.660317 — cell biology — Posted on 2025-06-18
1382 The Effects of Intraspecies and Interspecies Competition on Genetic Device Construction and Performance
Thompson, S.; Williams, A. R.; Dill, V.; Marshall, D.; Sawyer, E.; Alexander, M.; Rahn-Lee, L.; Shih, J. D.
10.1101/2025.06.17.660092 — synthetic biology — Posted on 2025-06-18
1383 Nucleosome-mediated conformational switches in micro-eccDNAs
Harris, S.; Velasco Berrelleza, V. M.; Sandel, W.; Sutthibutpong, T.; Parikh, V.; Ashley, E.; Fire, A.; Levene, S. D.; Bishop, T. C.; Shoura, M.
10.1101/2025.06.14.659616 — biophysics — Posted on 2025-06-18
1384 Pathogen effector forms a hexameric phosphatase holoenzyme with host core enzyme to promote disease
Wang, J.; Li, H.; Sun, W.; Wang, J.; Fang, X.; Yang, X.; Liu, C.; Sheng, G.; Ma, W.; Wang, Y.
10.1101/2025.06.14.659724 — biophysics — Posted on 2025-06-18
1387 Proximity-based super-resolution imaging enabled by DNA base-stacking interactions
Banerjee, A.; Yadav, S.; Vidwath, V. S.; Kalita, S.; Agasti, S.; Joshi, H.; Ganji, M.
10.1101/2025.06.14.659733 — biophysics — Posted on 2025-06-18
1388 RNA Selectively Modulates Activity of Virulent Amyloid PSMα3 and Host Defense LL-37 via Phase Separation and Aggregation Dynamics
Rayan, B.; Barnea, E.; Indig, R.; Pantoja, C. F.; Gayk, J.; Lupu-Haber, Y.; Upcher, A.; Argoetti, A.; Aunstrup Larsen, J.; Buell, A. K.; Zweckstetter, M.; Landau, M.
10.1101/2025.06.17.660072 — biophysics — Posted on 2025-06-18
1390 Lubricin's Mucin Domain Has Strong Polyproline Type-II Helical Character
Feng, B. N.; Mark, A. J.; Kim, F. S.; Naik, M. T.; Schimdt, T. A.; Elsaid, K.; Jay, G. D.; Rubenstein, B.
10.1101/2025.06.15.659778 — biophysics — Posted on 2025-06-18
1392 Screening de novo designed protein binders in unpurified lysate using flow induced dispersion analysis
Pinheiro, F.; Nowak, J. S.; Zueva, E.; Pheasant, E. C.; Kjaersgaard Grene, I.; Lampinen, V.; Kjaergaard, M.
10.1101/2025.06.17.660127 — biophysics — Posted on 2025-06-18
1394 Small molecule modulators of TOX protein re-invigorate T cell activity
Wu, B.; Chang, H. J.; Singh, P.; Hostetler, A.; Xiang, Y.; Guo, S.; Wang, F. Y.; Zhong, J. J.; Leifer, B. S.; Schiavoni, R. P.; Jiang, N.; Choudhary, A.; Westcott, P. M. K.; Koehler, A. N.
10.1101/2025.03.03.641115 — biochemistry — Posted on 2025-06-18
1396 Possible exposure to unidentified coronaviruses in roe deer (Capreolus capreolus) populations suggested by SARS-CoV-2 serological investigation in France
Perez, G.; Lalande, L. D.; Legros, V.; Kodjo, A.; Verheyden, H.; Bourret, V.; Cebe, N.; Chaval, Y.; Revelli, P.; Pellerin, M.; Lemaitre, J.-F.; Peroz, C.; Rey, B.; Debias, F.; Garcia, R.; Bourgoin, G.; Gilot-Fromont, E.
10.1101/2025.02.19.639030 — immunology — Posted on 2025-06-18
1397 Conserved cell state dynamics reveal targetable resistance patterns in ovarian high-grade serous carcinoma
Pirttikoski, A.; Gall-Mas, L.; Senkowski, W.; Fontaneda-Arenas, D.; Marin Falco, M.; Erkan, E. P.; Hynninen, J.; Wennerberg, K.; Vaharautio, A.
10.1101/2025.06.13.659489 — cancer biology — Posted on 2025-06-18
1400 On-skin, micro-objective enabled camera module for speckle contrast optical spectroscopy/tomography
Quiroga Soto, A. F.; Cortese, L.; Verma, M.; Dannberg, P.; Tachtsidis, I.; Danz, N.; Durduran, T.
10.1101/2025.06.12.659250 — bioengineering — Posted on 2025-06-18
1402 Shouldering the challenge of deciphering avian palate evolution
Benito, J.; Kuo, P.-C.; Torres, C. R.; Navalon, G.; Plateau, O.; Clark, A. D.; Steell, E. M.; Field, D. J.
10.1101/2025.06.10.658509 — evolutionary biology — Posted on 2025-06-18
1403 Thymic DC2 are heterogenous and include a novel population of transitional dendritic cells
Hogquist, K. A.; Voboril, M.; Sulczewski, F. B.; Martinez, R. J.; Ashby, K. M.; Valerio, M. M.; Idoyaga, J.
10.1101/2025.06.13.659520 — immunology — Posted on 2025-06-18
1404 Cellular composition of tissue-resident monocyte-lineage cells reveal functional heterogeneity during inflammatory arthritis
Wang, Y.; Dowlilng, S.; Maciuch, J.; Rodriguez, V.; Mayer, M.; Mian, K.; Therron, T.; Makinde, H. M.; Cuda, C.; Winter, D. R.; Perlman, H.
10.1101/2025.06.13.659432 — immunology — Posted on 2025-06-18
1408 Reversible Sandwich-Based Particle Nanoswitch for Continuous Protein Monitoring at Picomolar Concentrations with Automated Calibration
Michielsen, C. M. S.; Yan, J.; Lin, Y.-T.; Bergkamp, M. H.; Haenen, S. R. R.; Lubken, R. M.; Grawe, A.; Swietlikowska, A.; de Jong, A.; Prins, M. W. J.
10.1101/2025.06.13.659459 — bioengineering — Posted on 2025-06-18
1409 Machine Learning-Assisted Pathway Optimization in Large Combinatorial Design Spaces: a p-Coumaric Acid Case Study
Abeel, T.; van Lent, P.; Hoek, R. v. d.; Schmitz, J.; Paz, S. M.; Kooi, I.; Jonkers, M.; Zwartjens, P.
10.1101/2025.06.13.659482 — bioengineering — Posted on 2025-06-18
1411 Cross-scale visualization of RNA dynamics in whole plants using an RNA-triggered reporting system
Bai, J.; Chen, Y.; Zhang, J.; Li, J.; Ren, H.; Pan, S.; Tao, Y.; Lei, M.; Dong, M.; Liu, S.; Yi, J.; Chen, F.; Fan, C.; Zhao, Y.
10.1101/2025.03.03.641157 — molecular biology — Posted on 2025-06-18
1413 Population-specific brain charts reveal Chinese-Western differences in neurodevelopmental trajectories
Sun, L.; Qin, W.; Liang, X.; Wang, C.; Men, W.; Duan, Y.; Fan, X.-R.; Cai, Q.; Qiu, S.; Wang, M.; Gong, Q.; Tian, Y.; Liang, P.; Liu, Z.; Zhang, X.; Song, H.; Ye, Z.; Zhang, P.; Dong, Q.; Tao, S.; Zhu, W.; Zhang, J.; Xie, F.; Feng, J.; Zhang, J.; Liu, C.; Qian, Q.; Zhang, B.; Meng, M.; Hu, L.; Gao, J.-H.; Jiang, T.; Zhu, X.; Zhang, Y.; Liu, L.; Liu, H.; Liao, W.; Wang, D.; Wang, H.; Guo, T.; Dai, Z.; Lui, S.; Xu, K.; Li, L.; Xie, P.; Feng, C.; Cui, G.; Wu, J.; Yin, X.; Ding, G.; Xian, J.; Zhao, L.; Lu, J.; Liu, Z.; Han, Y.; Yuan, Z.; Zhang, X.; Si, T.; Zhou, F.; Bi, Y.; Wu, D.; Gao, F.; Wang,
10.1101/2025.06.17.659820 — neuroscience — Posted on 2025-06-18
1417 Immune pathways and perinatal environmental exposures contribute to epigenetic gestational age prediction and acceleration
Eapen, A. A.; Loveless, I. M.; Pan, M.; Liang, X.; Straughen, J.; Cassidy-Bushrow, A.; Sitarik, A. R.; Simmerman, N.; Thompson, E. E.; Kottyan, L.; Ober, C.; Johnson, C. C.; Zoratti, E.; Levin, A. M.
10.1101/2025.06.13.659090 — genomics — Posted on 2025-06-18
1419 An auxin-inducible degron system for trypanosomes
Carrington, M.; Klein, A.; McDowell, A.; Moura, D.; Reis, C. R. S.; de Freitas Nascimento, J.; Pontes de Lima, R.; de Melo Neto, O. P.
10.1101/2025.06.17.660065 — molecular biology — Posted on 2025-06-18
1420 High-resolution in situ structures of hantavirus glycoprotein tetramers
Guo, L.; McFadden, E.; Slough, M. M.; Stone, E. T.; Berrigan, J.; Mittler, E.; Hatzakis, K.; Hinkley, T.; Kain, H.; Ke, Z.; Warner, N. L.; Erasmus, J. H.; Chandran, K.; McLellan, J. S.
10.1101/2025.06.17.660152 — microbiology — Posted on 2025-06-18
1421 Nucleotide context models outperform protein language models for predicting antibody affinity maturation
Johnson, M. M.; Sung, K.; Haddox, H. K.; Vora, A. A.; Araki, T.; Victora, G. D.; Song, Y. S.; Fukuyama, J.; Matsen, F. A.
10.1101/2025.06.16.659977 — immunology — Posted on 2025-06-18
1426 A guide to the in vitro reconstitution of Cdc42 GTPase activity and its regulation
Tschirpke, S.; van Opstal, F.; van der Valk, R.; Daalman, W. K.-G.; Laan, L.
10.1101/2023.04.24.538075 — biochemistry — Posted on 2025-06-18
1435 MultiNMRFit: A software to fit 1D and pseudo-2D NMR spectra
Millard, P.; Le Gregam, L.; Dubiley, S.; Gabrielli, V.; Gosselin-Monplaisir, T.; Lippens, G.; Charlier, C.
10.1101/2024.12.19.629408 — bioinformatics — Posted on 2025-06-18
1436 An artificial nervous system for communication between wearable and implantable therapeutics
Ghanim, R.; Lee, Y. J.; Byun, G.; Jackson, J.; Ding, J. Z.; Feller, E.; Kim, E.; Aygun, D.; Kaushik, A.; Cig, A.; Park, J.; Healy, S.; Cunin, C. E.; Gumyusenge, A.; Yeo, W. H.; Abramson, A.
10.1101/2025.06.04.657863 — bioengineering — Posted on 2025-06-18
1437 Conformational Dynamics and Catalytic Backups in a Hyper-Thermostable Engineered Archaeal Protein Tyrosine Phosphatase
Yehorova, D.; Alansson, N.; Shen, R.; Denson, J. M.; Robinson, M.; Risso, V. A.; Molina, N. R.; Loria, J. P.; Gaucher, E.; Sanchez-Ruiz, J. M.; Hengge, A. C.; Johnson, S.; Kamerlin, S. C. L.
10.1101/2025.03.26.645524 — biochemistry — Posted on 2025-06-18
1438 Discovery of microsized RNA-derived RNAs and polypeptides in human cells
Huang, X.; Wu, H.; Zhong, W.; Li, W.; Liu, Z.; Yang, Z.; Zhao, M.; Xi, X.; Cao, B.; Pu, Y.; Kong, X.; Zhao, H.; Zhang, R.; Lai, K.; Lv, X.; Lv, Y.; Bao, J.; Wang, M.; Xiong, Y.; Liang, X.; Wu, X.; Wei, Z.; Xiong, Y.; Zhong, J.; Zhang, J.; Omenn, G. S.; Hu, Y.; Xu, J.; Zhang, G.; Chen, Y. E.; Chen, S.
10.1101/2023.04.24.538138 — biochemistry — Posted on 2025-06-18
1445 Overlapping yet Distinct Functions of VMP1 and TMEM41B in Modulating Hepatic Lipoprotein Secretion and Autophagy
Chen, A.; Nguyen, K.; Jiang, X.; Yu, X.; Xie, Y.; Liu, W.; Davidson, N.; Ding, W.-X.; Ni, H.-M.
10.1101/2025.04.07.647617 — cell biology — Posted on 2025-06-18
1447 Tandem sulfofucolytic-sulfolactate sulfolyase pathway for catabolism of the rare sulfosugar sulfofucose
Stewart, A.; Li, J.; Lee, M.; Lewis, J. M.; Herisse, M.; Hofferek, V.; McConville, M. J.; Pidot, S. J.; Scott, N. E.; Williams, S. J.
10.1101/2023.08.01.551581 — microbiology — Posted on 2025-06-18
1448 A first-in-kind MAPK13 inhibitor corrects stem cell reprogramming and muco-obstructive lung disease
Zhang, Y.; Wu, K.; Mao, D.; Iberg, C. A.; Yin-Declue, H.; Sun, K.; Wikfors, H. A.; Keeler, S. P.; Li, M.; Young, D.; Yantis, J.; Crouch, E. C.; Chartock, J. R.; Han, Z.; Broschat, K. O.; Byers, D. E.; Brody, S. L.; Romero, A. G.; Holtzman, M. J.
10.1101/2024.08.21.608990 — immunology — Posted on 2025-06-18
1449 Sub-second analysis of locomotor activity in Parkinsonian mice
Berezhnoi, D.; Chehade, H. D.; Simms, G.; Chen, L.; SIVANVAYAL NARASIMHAN, K. K.; Dravid, S.; Chu, H.-Y.
10.1101/2024.12.26.630411 — neuroscience — Posted on 2025-06-18
1450 Longitudinal Habituation and Novelty Detection neural responses from infancy to early childhood in The Gambia and UK
Blasi Ribera, A.; Blanco Maniega, B.; McCann, S.; Mbye, E.; Touray, E.; Rozhko, M.; Milosavljevic, B.; Katus, L.; Saidykhand, M.; Ceesay, M.; Fadera, T.; Ghillia, G.; Perapoch Amado, M.; Crespo-Llado, M. M.; Moore, S. E.; Elwell, C. E.; Lloyd-Fox, S.
10.1101/2025.05.23.655801 — neuroscience — Posted on 2025-06-18
1451 Unintended bias in the pursuit of collinearity solutions in fMRI analysis
Mumford, J. A.; Demidenko, M. I.; Bjork, J. M.; Chaarani, B.; Feczko, E. J.; Garavan, H. P.; Hagler, D. J.; Nelson, S. M.; Wager, T. D.; Poldrack, R. A.
10.1101/2025.01.14.633053 — neuroscience — Posted on 2025-06-18
1452 Partial Input Loss Differentially Modifies Neural Pathways
Lee, J. Y.; Kastner, D. B.; Harris, S. C.; Santina, L. D.; John, J. V.; Stone, N. S.; Dunn, F. A.
10.1101/2025.02.14.638366 — neuroscience — Posted on 2025-06-18
1453 Astrocytes modulate neuronal development by S100A6 signaling
Harkany, T.; Cinquina, V.; Calvigioni, D.; Tretiakov, E. O.; Piscitelli, F.; Keimpema, E.; Di Marzo, V.; Verkhratsky, A.
10.1101/2023.09.05.556314 — neuroscience — Posted on 2025-06-18
1455 Ketone body driven lipid remodeling supports thermogenic adaptation to fasting
Moazzami, Z.; Queathem, E. D.; Ma, J.; Chen, Q.; Arianti, R.; Aden, I.; Brown, A.; Abdulahi, Z.; Gu, C.; Chang, X.; Li, Y.; Yu, H.; Bartolomucci, A.; Panda, S.; Mashek, D. G.; Kristof, E.; Puchalska, P.; Chow, L. S.; Jia, Z.; Crawford, P. A.; Ruan, H.-B.
10.1101/2025.06.13.659540 — physiology — Posted on 2025-06-17
1456 β2AR Agonists Sustain Thermogenesis and Leanness via Sympathofacilitation
Cheung, S. W.; Sidarta-Oliveira, D.; Yao, L.; Zhu, Y.; Sarker, G.; Lundh, S.; Morgan, D. A.; Qu, J.; Wilcox, S.; Vyazovskiy, V.; Paterson, D. J.; Li, D.; Rahmouni, K.; Domingos, A.
10.1101/2025.06.13.659468 — physiology — Posted on 2025-06-17
1460 Non-disruptive 3D profiling of combinations of epigenetic marks in single cells
Chen, Y.; Radda, J. S. D.; Alderman, M. H.; Jin, S.; Cheng, Y.; Zhang, Y.; Liu, M.; Xiao, A.; Wang, S.
10.1101/2025.06.13.659535 — genetics — Posted on 2025-06-17
1463 HIF-1α+ CD4 T cells coordinate a tissue resident immune cell network in the lung
de Lima, J.; Swarnalekha, N.; Bartoszek, E.; Litzler, L. C.; Depew, C. E.; Esposito, M.; Erber, M.; Kunzli, M.; Shenoy, A. T.; Goldrath, A. W.; Sun, J.; Schreiner, D.; King, C. G.
10.1101/2025.06.13.659476 — immunology — Posted on 2025-06-17
1464 AAV gene therapy for GBA-PD and Gaucher Disease
Ayloo, S.; Ryu, J.; Chou, S.-C.; Blatnik, L.; Wischhof, E.; Bu, J.; Guo, L.; Hossain, M.; Ghosh, D.; McCarty, W.; Bryne, A.; Chai, L.; Clarke, J.; Kayatekin, C.; Zhang, B.; Sardi, P.; Goulet, M.; Elmer, B.; Mueller, C.; Ramachandran, S.
10.1101/2025.06.17.660133 — neuroscience — Posted on 2025-06-17
1465 RNAGym: Large-scale Benchmarks for RNA Fitness and Structure Prediction
Arora, R.; Angelo, M.; Choe, C. A.; Shearer, C.; Kollasch, A.; Qu, F.; Weitzman, R.; Gazizov, A.; Gurev, S.; Xie, E.; Marks, D. S.; Notin, P.
10.1101/2025.06.16.660049 — synthetic biology — Posted on 2025-06-17
1466 Anti-activin treatment increases T cell infiltration in breast and pancreatic tumours and promotes survival in a SMAD4-null mouse pancreatic cancer model
McCluney, S.; Park, D.; Miller, D. S.; Mehic, M.; Bloxham, R. D.; De Vries, E.; Wang, X.; Boeing, S.; D'Antonio, L.; Wieteska, L.; Pyeatt, G.; Strohbuecker, S.; Chakravarty, P.; Maia De Oliveira, T.; Wilcockson, R.; Hyvonen, M.; Hunt, J.; Hill, C. S.
10.1101/2025.06.13.659133 — cancer biology — Posted on 2025-06-17
1467 MEK inhibition induces AXIN1 loss in colorectal cancer by mTOR associated suppression of protein synthesis
Venkatachalam, N.; Wang, L.; Muthukumarana, N.; Ihnatko, R.; Krijgsveld, J.; Skabkina, O.; Leipertz, A.; Chen, Y.; Betge, J.; Boonekamp, K.; Boutros, M.; Stoecklin, G.; Ebert, M.; Schott, J.; Zhan, T.
10.1101/2025.06.13.659446 — cancer biology — Posted on 2025-06-17
1470 Attomolar Detection of HIV-1 with Label-Free RCA-rCRISPR on Smartphone
Mohammad, N.; Steksova, A.; Tang, Y.; Huang, L.; Velayati, A.; Zhang, S.; Dey Poonam, A.; Jamalzadegan, S.; Breen, M.; Jiang, G.; Wei, Q.
10.1101/2025.06.15.659809 — bioengineering — Posted on 2025-06-17
1471 Genome editing of phylogenetically distinct bacteria using portable retron-mediated recombineering
Gonzalez-Delgado, A.; Bonillo-Lopez, L.; Johnson, M. S.; Knoedlseder, N.; Ko, C.-C.; Lekbach, Y.; Oh, J.-H.; Selvakumar, H.; Wold, M. C.; Yu, Z.; Aragon, V.; Gralnick, J. A.; Guell, M.; Hatfull, G.; Keitz, B. K.; Koskella, B.; Mutalik, V. K.; van Pijkeren, J. P.; Shipman, S.
10.1101/2025.06.16.660010 — bioengineering — Posted on 2025-06-17
1474 Prime assembly with linear DNA donors enables large genomic insertions
Liu, B.; Petti, A.; Zhou, X.; Cheng, H.; Zhou, L.; Jiang, T.; Sontheimer, E. J.; Xue, W.
10.1101/2025.06.16.659978 — biochemistry — Posted on 2025-06-17
1477 Super-giga and tiny orchid genomes illuminate evolution of Orchidaceae
Lan, S.; Liu, K.-W.; Li, Z.; Hsiao, Y.-Y.; Liu, Y.; Zhang, D.; Zhao, X.; Sun, W.-H.; Liu, D.-K.; Huang, M.-Z.; Zhou, C.-Y.; Zeng, M.; Wang, L.; Zheng, R.; Zhao, Z.; Gao, X.; Lai, J.-H.; Yeh, K.-L.; Zhang, L.-S.; Chen, J.; Ma, X.; Li, Y.; Chen, D.; Li, J.; Zhang, M.-M.; He, X.; Huang, Y.; Zhang, C.; Wu, X.; Chen, C.; Ma, L.; Zhai, J.; Ai, Y.; Li, M.-H.; Zhou, Y.; Zhou, Z.; Wu, S.; Zhao, K.; Guan, Y.; Tu, X.-D.; Zeng, D.; Ji, X.; Liu, N.; Zou, S.; Chen, Y.-Y.; Lin, S.-T.; Su, W.-Y.; Wang, Z.-W.; Luo, Y.-B.; Zhang, W.; Guo, Y.-Y.; Tian, Y.-Q.; Zou, L.-H.; Lv, X.; Zhuo, X.; Zhu, J.; Peng, D.-H.; Y
10.1101/2025.06.13.659439 — genomics — Posted on 2025-06-17
1478 Recombination Rates Are Governed by Sex-Specific Evolutionary Programs in House Mice
Wooldridge, L. K.; Pietraho, M.; DiSiena, P.; Littman, S. D.; Clauss, B. R.; Dumont, B. L.
10.1101/2025.06.16.659996 — evolutionary biology — Posted on 2025-06-17
1480 HPAI virus transmission is shaped by inter-specific social network structure
Dunning, J.; Gamza, A.; Firth, J.; Ashton-Butt, A.; Kao, R. R.; Brown, I.; Ward, A.
10.1101/2025.06.17.659947 — ecology — Posted on 2025-06-17
1482 UFMylation orchestrates chromatin engagement of core NHEJ components to promote DNA double-strand break repair
Wang, Z.; Foster, B. M.; da Costa, I. C.; Wu, Y.; Behera, D.; Conte, F.; Trotter, E. W.; Cabello-Lobato, M. J.; Choudhary, S.; Wiener, R.; Beli, P.; Smith, D. L.; Banks, W. H.; Bagley, S.; McKee, S.; Minnis, M.; Meyer, S.; Chaplin, A. K.; Doerner, W.; Mootz, H. D.; Hagan, I. M.; Galanty, Y.; Larrosa, I.; Cliff, M. J.; Schmidt, C. K.
10.1101/2025.06.16.659844 — molecular biology — Posted on 2025-06-17
1483 Detection of West Nile Virus via Retrospective Mosquito Arbovirus Surveillance in the United Kingdom
Bruce, R. C.; Abbot, A. J.; Jone, B. P.; Gardener, B. L.; Gonzalez, E.; Ionescu, A.-M.; Jagdev, M.; Jenkins, A.; Santos, M.; Seilern-Macpherson, K.; Hanmer, H. J.; Robinson, R. A.; Vaux, A. G. C.; Johnson, N.; Cunningham, A. A.; Lawson, B.; Medlock, J. M.; Folly, A. J.
10.1101/2025.06.17.659932 — molecular biology — Posted on 2025-06-17
1485 Bacteria deliver a microtubule-binding protein into mammalian cells to promote colonization
Costello, M. S.; Neumann, B. C.; Cuthbert, B. J.; Holubova, J.; Raimondi, M. W.; Garza-Sanchez, F.; Samad, A.; Bumba, L.; Torres, J. A.; Holznecht, N.; Mendoza, J.; Stanek, O.; Prombhul, S.; Weimbs, T.; Morrissey, M. A.; Acosta-Alvear, D.; Low, D. A.; Sebo, P.; Goulding, C. W.; Gonen, S.; Hayes, C. S.
10.1101/2025.06.17.660209 — microbiology — Posted on 2025-06-17
1487 Evidence for the acquisition of a proteorhodopsin-like rhodopsin by a chrysophyte-infecting giant virus
Byl, P.; Schvarcz, C. R.; Thomy, J.; Li, Q.; Williams, C. B.; LaButti, K.; Schulz, F.; Edwards, K. F.; Steward, G. F.
10.1101/2025.06.17.660233 — microbiology — Posted on 2025-06-17
1490 Integrative Structure of Norovirus NS3 Suggests a Role in RNA Transport
Haas, M.; Mills, J. T.; Kelley, C.; Das, A.; Hof, H.; Niemel, C.; Donselaar, T.; Drulyte, I.; van Kuppeveld, F. J. M.; Dulin, D.; Snijder, J.; Herod, M. R.; Hurdiss, D. L.
10.1101/2025.06.17.659504 — microbiology — Posted on 2025-06-17
1494 Identification of pseudotetraivprolide from Pseudomonas entomophila give novel insights into the biosynthesis of detoxin/rimosamide-like anti-antibiotics
Bode, E.; Buellesbach, J.; Bauer, K.; Shi, Y.-N.; Reiners, S.; Cui, Z.; Happel, P.; Shi, Y.-M.; Kazmaier, U.; Grininger, M.; Bode, H. B.
10.1101/2025.06.17.660182 — microbiology — Posted on 2025-06-17
1495 A generalized and efficient approach for complete mRNA design improves translation, stability and specificity
Riley, A. T.; Vlasity, M.; Huang, J. Z.; Becicka, W. M.; Wong, W. W.; Grinstaff, M. W.; Green, A. A.
10.1101/2025.06.17.659751 — synthetic biology — Posted on 2025-06-17
1496 Transcriptomic analysis of genotypes derived from Rosa wichurana unveils molecular mechanisms associated with quantitative resistance to Diplocarpon rosae
Lambelin, L.; Thouroude, T.; Jeauffre, J.; Chameau, J.; Vilfroy, C.; Boursier, C.; Aubourg, S.; Pelletier, S.; Lopez Arias, D. C.; Hibrand-Saint Oyant, L.; Soufflet-Freslon, V.; Foucher, F.; Paillard, S.
10.1101/2025.06.13.659350 — plant biology — Posted on 2025-06-17
1497 Open-science discovery of DNDI-6510, a compound that addresses genotoxic and metabolic liabilities of the COVID Moonshot SARS-CoV-2 Mpro lead inhibitor
Griffen, E. J.; Fearon, D.; McGovern, B. L.; Koekemoer, L.; Balcomb, B. H.; Szommer, T.; Fate, G.; Robinson, R. P.; Lefker, B. A.; Duberstein, S.; Lahav, N.; Braillard, S.; Vangeel, L.; Laporte, M.; Charvillon, F. B.; MacLeod, A. K.; Wells, A.; Garner, P.; Knight, R.; Rees, P.; Simon, A.; Jochmans, D.; Neyts, J.; Read, K. D.; Barr, H.; Robinson, M.; Lee, A. A.; London, N.; Chodera, J.; von Delft, F.; White, K. M.; Perry, B.; Sjo, P.; von Delft, A. R.
10.1101/2025.06.16.660018 — pharmacology and toxicology — Posted on 2025-06-17
1500 Preclinical evaluation of CHDI-009R for quantification of mutant huntingtin aggregates
Zajicek, F.; Everix, L.; Van Eetveldt, A.; Verhaeghe, J.; De Lombaerde, S.; Miranda, A.; Akkermans, J.; Dominguez, C.; Khetarpal, V.; Bard, J.; Liu, L.; Staelens, S.; Bertoglio, D.
10.1101/2025.06.17.660088 — neuroscience — Posted on 2025-06-17
1501 High throughput machine learning pipeline to characterize larval zebrafish motor behavior
Hageter, J.; Efromson, J.; Alban, B.; DelGaudio, A.; Saliu, V.; Wassef, M.; Harfouche, M.; Horstick, E. J.
10.1101/2025.06.17.660164 — neuroscience — Posted on 2025-06-17
1503 Alpha rhythm subharmonics underlie responsiveness to theta burst stimulation via calcium metaplasticity
Kadak, K.; Momi, D.; Wang, Z.; Bastiaens, S. P.; Oveisi, M. P.; Morshedzadeh, T.; Ismail, M.; Fousek, J.; Griffiths, J. D.
10.1101/2025.06.17.660153 — neuroscience — Posted on 2025-06-17
1504 Emergence of multifrequency activity in a laminar neural mass model
de Palma Aristides, R.; Clusella, P.; Sanchez-Todo, R.; Ruffini, G.; Garcia-Ojalvo, J.
10.1101/2025.06.16.659878 — neuroscience — Posted on 2025-06-17
1506 Improving Recombinant Antibody Production Using FcBAR: An In Situ Approach to Detect and Amplify Protein-Protein Interactions
Wu, M. Y. M.; Rocamora, F.; Samoudi, M.; Robinson, C.; Kuo, C.-C.; Pristovsek, N.; Grav, L. M.; Kildegaard, H. F.; Lee, G. M.; Campos, A. R.; Lewis, N. E.
10.1101/2025.06.12.659199 — systems biology — Posted on 2025-06-17
1507 Foot placement coordination is impaired in people with Parkinson's Disease
Lang, C.; Hausdorff, J. M.; Bruijn, S. M.; Brodie, M. A.; Okubo, Y.; Maetzler, W.; van Leeuwen, A. M.; Singh, N. B.; van Dieen, J. H.; Ravi, D. K.
10.1101/2025.06.11.659042 — pathology — Posted on 2025-06-17
1509 Uncertainty-aware quantitative analysis of high-throughput live cell migration data
Kitanovski, S.; Conroy, S.; Sonneck, J.; Dorsch, M.; Urban, S.; Chen, J.; Grüner, B.; Hoffmann, D.
10.1101/2025.06.12.659342 — bioinformatics — Posted on 2025-06-17
1513 Discovery of iridoid cyclase completes the iridoid pathway in asterids
Colinas, M.; Tymen, C.; Wood, J. C.; David, A.; Wurlitzer, J.; Morweiser, C.; Gase, K.; Alam, R. M.; Titchiner, G. R.; Hamilton, J. P.; Heinicke, S.; Dirks, R. P.; Lopes, A. A.; Caputi, L.; Buell, C. R.; O'Connor, S. E.
10.1101/2025.06.12.659277 — plant biology — Posted on 2025-06-17
1514 Ablation of Prdm16 and beige fat causes vascular remodeling and elevated blood pressure
Koenen, M.; Becher, T.; Pagano, G.; Del Gaudio, I.; Barrero, J. A.; Montezano, A. C.; Ortiz, J. R.; Lin, Z.; Gomez-Banoy, N.; Amblard, R.; Kars, M. E.; Rubinelli, L.; Halix, S. J.; Cao, Z. H.; Zeng, X.; Butler, S. D.; Itan, Y.; Touyz, R. M.; Di Lorenzo, A.; Cohen, P.
10.1101/2025.06.12.658904 — physiology — Posted on 2025-06-17
1518 Microstate in rats EEG: a proof of concept study
Piorecka, V.; Vejmola, C.; Peskova, P.; Piorecky, M.; Jiricek, S.; Koudelka, V.; Griskova-Bulanova, I.; Palenicek, T.
10.1101/2025.06.17.660121 — animal behavior and cognition — Posted on 2025-06-17
1520 Disentangling the role of chromosome inversions in the structure of flat oyster (Ostrea edulis): origin, adaptation and phylogeography
Sambade, I. M.; Hlordzi, V.; Blanco, A.; Hermida, M.; Vera, M.; Culloty, S.; Bean, T.; Lynch, S.; Martinez, P.
10.1101/2025.06.12.659260 — genomics — Posted on 2025-06-17
1526 Targeted Inhibition of Translation Initiation via 2'O-Methylation of Start Codons
Patrasso, E. A.; Serio, H.; Suh, A.; Mou, S.; Vasquez, K.; Wu, S.; Yi, Y.; Arango, D.
10.1101/2025.06.14.659565 — molecular biology — Posted on 2025-06-17
1527 Tissue-resident neutrophils serve homeostatic and immunological functions in embryos
Hofmann, J.; Lintukorpi, L.; Lokka, E.; Ojasalo, V.; Cisneros Montalvo, S.; Kaukonen, D.; Ma, L.; Kotaja, N.; Gerke, H.; Salmi, M.; Rantakari, P.
10.1101/2025.06.12.659311 — immunology — Posted on 2025-06-17
1529 Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunization
Ghosh, A. R.; Habib, R.; Mishra, N.; Roark, R. S.; Akauliya, M.; Albowaidey, A. A.; Allen, J. D.; Amereh, K.; Avillion, G.; Bottermann, M.; Liang, B.; Chaudhary, N.; Callaghan, S.; Dye, J.; Li, X.; Ellis-Pugh, J. R.; Chowdhury, R. R.; James, N. E.; Liu, X.; Maiorino, L.; Villavicencio, P. M.; Nedellec, R.; Oberoi, P.; Sowers, K. J.; Park, Y.; Prum, T.; Rodriguez, L.; Ssozi, M.; Torres, J.; Walsh, A. A.; Warner, J. E.; Weldon, S. R.; Xu, L.; Wiehe, K.; Crispin, M.; Ward, A. B.; Nair, U.; Hahn, B. H.; Burton, D. R.; Shapiro, L.; Kwong, P. D.; Irvine, D. J.; Andrabi, R.; Shaw, G. M.; Batista, F.
10.1101/2025.06.12.659380 — immunology — Posted on 2025-06-17
1530 Multitargeted Reduction of Inflammation and Atherosclerosis in Tet2-deficient CHIP via XPO1 Inhibition and Atf3 restoration
Prutsch, N.; Vromman, A.; Leeper, B.; Chen, M.; Keating, J. H.; He, S.; Berezovskaya, A.; Ren, S.; Gomes, M. J.; Folco, E. J.; Rauch, P. J.; Gokhale, P. C.; Zimmerman, M. W.; Neuberg, D. S.; Abraham, B. J.; Libby, P.; Look, A. T.
10.1101/2025.06.12.658927 — immunology — Posted on 2025-06-17
1532 Spatially-distinct programming of macrophage diversity within the granulomas of Mycobacterium tuberculosis infected nonhuman primates
Pisu, D.; Sunny, P. S.; Nelson, M. L.; Juneco, B. F.; Venugopalan, R.; Rodgers, M.; Borish, H. J.; Maiello, P.; Scanga, C. A.; Lin, P. L.; Flynn, J. L.; Russell, D. G.; Mattila, J.
10.1101/2025.06.12.659348 — immunology — Posted on 2025-06-17
1535 Behavioural, biochemical and functional phenotyping of chronic exposure to chlordecone in mice
VULIN, J. J.; Chauveau, F. F.; Dure, C. C.; Humo, M. M.; Valdebenito, M. M.; Aufauvre, C. C.; Vidal, L. L.; Verchere, J. J.; Decesar, A. A.; Gaillard, D. D.; Lakdhar, L. L.; BARON, T.; LAVISON-BOMPARD, G. G.; VIDAL, B.
10.1101/2025.06.16.659846 — neuroscience — Posted on 2025-06-17
1537 HIPPOCAMPAL THETA OSCILLATIONS DURING CONTROLLED SPEED RUNS ON A TREADMILL
Furtunato, A. M. B.; Marques da Silva, D.; Tort, A. B.; Lobao-Soares, B.; Belchior, H.
10.1101/2025.06.17.660140 — neuroscience — Posted on 2025-06-17
1538 Brain Representations of Natural Sound Statistics
Mohammadi, Y.; Billig, A. J.; Berger, J. I.; Griffiths, T.
10.1101/2025.06.17.660096 — neuroscience — Posted on 2025-06-17
1539 Robust functional ultrasound imaging in the awake and behaving brain: a systematic framework for motion artifact removal
Le Meur-Diebolt, S.; Pereira, F. C.; Mariani, J.-C.; Kliewer, A.; Farinha-Ferreira, M.; Bertolo, A.; Osmanski, B.-F.; Lenkei, Z.; Deffieux, T.
10.1101/2025.06.16.659882 — neuroscience — Posted on 2025-06-17
1542 Tamarixia citricola Hansson and Guerrieri sp. nov. (Hymenoptera: Eulophidae): a new parasitoid of Diaphorina citri Kuwayamava (Hemiptera: Psyllidae) found during a classical biological control program in Cyprus
Urbaneja, A.; Perez-Hedo, M.; Seraphides, N.; Melifronidou- Pantelidou, A.; Giallouridou, S.; Markou, L.; Stavrinides, M.; Kaponas, C.; Ruiz-Rivero, O.; Morgan, D. J. W.; Hansson, C.; Hoddle, M. S.; Tena, A.; Guerrieri, E.
10.1101/2025.06.16.660002 — zoology — Posted on 2025-06-17
1543 Impact of tusk anomalies on the long-term foraging ecology of narwhals
Louis, M.; Rey-Iglesia, A.; Routledge, J.; de Jager, D.; Skovrind, M.; Heide-Jorgensen, M. P.; Kaiser, T. M.; Kovacs, K. M.; Lydersen, C.; Rosing-Asvid, A.; Szpak, P.; Lorenzen, E.
10.1101/2025.06.17.660143 — zoology — Posted on 2025-06-17
1544 Modeling cellular influence delineates functionally relevant cellular neighborhoods in primary and metastatic pancreatic ductal adenocarcinoma.
Cho, Y.; Lee, J. W.; Shin, S. M.; Hernandez, A. G.; Yuan, X.; Schneider, J.; Hooper, J. E.; Wood, L. D.; Jaffee, E. M.; Deshpande, A.; Ho, W. J.
10.1101/2025.06.12.659314 — systems biology — Posted on 2025-06-17
1546 Loss of HNF1b drives pancreatic Intraductal Papillary Mucinous Neoplasms (IPMN) initiation
LORENZO, D.; AGUILERA MUNOZ, L.; MARSTRAND-DAUCE, L.; CHASSAC, A.; NICOLE, P.; MENG, L.; HEIDET, L.; KNEBELMANN, B.; PIGNOLET, C.; DOBLAS, S.; COUVINEAU, A.; ESPOSITO, I.; REBOURS, V.; NICOLLE, R.; CROS, J.; COUVELARD, A.; HAUMAITRE, C.
10.1101/2025.06.12.659269 — pathology — Posted on 2025-06-17
1548 Genetic barcoding uncovers the clonal makeup of solid and liquid biopsies
Merino, D.; Serrano, A.; Weber, T.; Berthelet, J.; Ftouni, S.; El-Saafin, F.; Wimmer, V.; Rogers, K. L.; Lim, E.; CHARAFFE-JAUFFRET, E.; Ginestier, C.; Williams, D.; Hollande, F.; Yeo, B.; Dawson, S.-J.; Naik, S.
10.1101/2025.06.12.659267 — cancer biology — Posted on 2025-06-17
1550 Bayesian Nonparametrics for FRET using Realistic Integrative Detectors
Saurabh, A.; Wisna, G. B. M.; Schweiger, M. C.; Hariadi, R. F.; Presse, S.
10.1101/2025.06.12.659382 — biophysics — Posted on 2025-06-17
1551 Inferring Spatially Varying Bending Stiffness of Biopolymers with Deep-Learning Approach
Hong, C.; Lim, C.; Oh, J.; Lee, J.-B.; Jeong, E. E.; Yoo, J.-Y.; Kim, W. K.; Jeon, J.-H.
10.1101/2025.06.12.659266 — biophysics — Posted on 2025-06-17
1552 The soluble HIV-1 Vpu protein interacts with calmodulin in a Ca2+-dependent manner
Ishola, O.; Islam, M. M.; Hadadianpour, E.; Borbat, P. P.; Georgieva, E. R.
10.1101/2025.06.12.658902 — biophysics — Posted on 2025-06-17
1557 VISIBLE: An imaging-driven system for sampling, biofabrication, and manipulation of complex biological models
Joshi, S.; Moreno-Gonzalez, C.; Suklai, P.; Carraro, E.; Ratcliffe, C. D. H.; Boezio, G. L. M.; Konstantinou, G.; Hagemann, C.; Kavanagh, T.; Ameer-Beg, S.; Imbert, A.; Sahai, E.; Tedesco, F. S.; Serio, A.
10.1101/2025.06.12.659321 — bioengineering — Posted on 2025-06-17
1560 Hybrid Scaffolds Decouple Biochemical & Biophysical Regulation of Cell Phenotype
Song, X.; Mitchell, S. C.; Smart, A. N.; Hardiman, W.; Bax, D. V.; Staley, C. E.; Probert, C.; Collier, P.; Meakin, M.; Ritchie, A. A.; Mendonca, T.; Wright, A. J.; James, V.; Grabowska, A. M.; Merry, C. L.; Best, S. M.; Cameron, R. E.; Ashworth, J. C.
10.1101/2025.06.12.659085 — bioengineering — Posted on 2025-06-17
1561 The Filterprep: A Simple and Efficient Approach for High-Yield, High-Purity Plasmid DNA Purification
Cheng, Y.-H.; Wu, Y.-J.; Shih, Y.-C.; Lin, Y.-Q.; Chang, Y.-W.; Wu, Y.-H.; Hu, E.-W.; Ku, R.-H.; Wu, C.-M.; Wu, S.-C.; Yeh, T.-Y.; Chang, C.-T.
10.1101/2025.06.12.659418 — biochemistry — Posted on 2025-06-17
1563 How cBAF and PBAF regulate the nucleosomal and subnucleosomal landscape of promoters, enhancers and REST repressor binding sites
GERARD, M.; Soleil, M.; Drouineau, E.; Nocente, M. C.; Karamitsos, A. M.; Moroziuk, Y. K.; Picaud, H.; Dulary, C.; Chantalat, S.
10.1101/2025.06.12.659349 — genomics — Posted on 2025-06-17
1567 Inhibition of De Novo Autoantibody Production Attenuates Chronic Antibody-Mediated Rejection of Kidney Allografts Despite Maintenance of High Donor-Specific Antibody Titers
Mitsui, Y.; Keslar, K. S.; Nicosia, M.; Kish, D. D.; Dvorina, N.; Zhu, C.; Olman, M.; Southern, B. D.; Baldwin, W. M.; Fairchild, R. L.
10.1101/2025.06.11.659154 — immunology — Posted on 2025-06-17
1568 Succinate enhances mitochondrial metabolism and phagocytosis in human airspace monocytes
Slattery, K.; Newing, A.; McGrath, J.; Sanfeliu, A.; O Gallchobhair, O.; Faherty, L.; McNally, E.; O Connell, F.; Nadarajan, P.; Mitchell, P.; Donnelly, S.; Cloonan, S. M.; Keane, J.; Gleeson, L.
10.1101/2025.06.12.659271 — immunology — Posted on 2025-06-17
1571 Omega-3 Fatty Acid Synergy with Glucocorticoid in Lupus Macrophages: Targeting Pathogenic Pathways to Reduce Steroid Dependence
Heine, L. K.; Nault, R.; Jackson, J.; Anderson, A. N.; Harkema, J. R.; Olive, A. J.; Pestka, J. J.; McDonald, O. F.
10.1101/2025.06.12.658906 — immunology — Posted on 2025-06-17
1572 Meteorin resolves nociceptive hypersensitivity by reducing connexin-mediated coupling in satellite glial cells
Pallesen, L. T.; Petersen, A.-K.; Sankaranarayanan, I.; Feldman-Goriachnik, R.; Ahlgreen, O. A.; Pinheiro, A. M.; Baake, J.; Hansen, M. W.; Richner, M.; Ellegaard, L. D.; Rossi, R.; Petersen, K. A.; Fjord-Larsen, L.; Olsen, J. V.; Munro, G.; Hanani, M.; Price, T. J.; Vaegter, C. B.
10.1101/2025.06.16.659847 — neuroscience — Posted on 2025-06-17
1573 Global hypoperfusion leads to a mismatch in oxygen delivery and consumption in the cerebral watershed area
Li, B.; Cao, H.; Takase, H.; Allu, S. R.; Wu, Y.; Fu, B.; Vinogradov, S. A.; Arai, K.; Lo, E. H.; Ayata, C.; Sakadzic, S.
10.1101/2025.06.16.659854 — neuroscience — Posted on 2025-06-17
1574 Dorsal Striatum Parvalbumin interneurons translatome unveiled
Naon, C.; Castell, L.; Thirard, S.; Moreno, M.; Rialle, S.; Goetz, E.; Casals, E.; Rogliardo, A.; Gut, M.; Esteve-Codina, A.; Quintana, A.; Bertaso, F.; Valjent, E.; Cutando, L.
10.1101/2025.06.16.659856 — neuroscience — Posted on 2025-06-17
1575 Image-Based Meta- and Mega-Analysis (IBMMA): A Unified Framework for Large-Scale, Multi-Site, Neuroimaging Data Analysis
Steele, N.; Morey, R.; Hussain, A.; Russell, C.; Suarez-Jimenez, B.; Pozzi, E.; Jameei, H.; Schmaal, L.; Veer, I.; Waller, L.; Jahanshad, N.; Thomopoulos, S.; Salminen, L.; Olff, M.; Frijling, J.; Veltman, D.; Koch, S.; Nawijn, L.; van Zuiden, M.; Wang, L.; Zhu, Y.; Li, G.; Stein, D.; Ipser, J.; Neria, Y.; Zhu, X.; Ravid, O.; Zilcha-Mano, S.; Lazarov, A.; Huggins, A.; Stevens, J.; Ressler, K.; Jovanovic, T.; van Rooij, S.; Fani, N.; Mueller, S.; Hudson, A.; Daniels, J.; Sierk, A.; Manthey, A.; Walter, H.; van der Wee, N.; van der Werff, S.; Vermeiren, R.; Schmahl, C.; Herzog, J.; Rektor, I.; i
10.1101/2025.06.16.657725 — neuroscience — Posted on 2025-06-17
1578 Metabolic resilience rules sex-specific pain recovery during hormonal aging: a multi-omics analysis of neuropathy in mice.
Marinelli, S.; Rossi, C.; Pieroni, L.; Giacovazzo, G.; Vacca, V.; De Angelis, F.; Cicalini, I.; Mastrorilli, V.; Parisi, C.; Yurtseve, Z. N.; Ciavardelli, D.; Coccurello, R.
10.1101/2025.06.17.659987 — neuroscience — Posted on 2025-06-17
1581 Deep Learning-enabled Sperm Morphology Analysis of Bovine Sperm for label-free Imaging Flow Cytometry
Umirbaeva, A.; Kurenkov, A.; Seisenov, B.; Zhumanov, K.; Tajiyev, K.; Mustafin, M.; Vorobjev, I. A.; Barteneva, N. S.
10.1101/2025.06.12.659335 — systems biology — Posted on 2025-06-17
1582 Systems-level Consequences of Low RAF Abundance for EGFR-ERK Signaling
Lee, S. H.; Myers, P. J.; Brown, K. S.; Loew, L. M.; Sorkin, A.; Lazzara, M. J.
10.1101/2025.06.12.659034 — systems biology — Posted on 2025-06-17
1583 Non-Thermal Plasma Activated Water is an Effective Nitrogen Fertilizer Alternative for Arabidopsis thaliana
Kizer, J. J.; Robinson, C. D.; Lucas, T.; Shannon, S.; Hernandez, R.; Stapelmann, K.; Rojas-Pierce, M.
10.1101/2025.06.12.659237 — plant biology — Posted on 2025-06-17
1584 A bioenergetic basis for multiorgan dysfunction in sepsis
Jentho, E.; Ademolue, T. W.; Peters-Sengers, H.; Butler, J. M.; Xu, L.-L.; Trikha Rastogi, S.; Kitoko, J.; Pagnotta, S.; Drotleff, B.; Faisca, P.; Polishchuk, V.; Mesquita, M.; Horn, P.; Metzing, U. B.; Cardoso, S.; Mithieux, G.; Bauer, M.; Chouchane, O.; Weis, S.; Panagiotou, G.; von Loeffelholz, C.; van der Poll, T.; Soares, M.
10.1101/2025.06.12.659280 — pathology — Posted on 2025-06-17
1585 Deciphering DEL Pocket Patterns Through Contrastive Learning
Zhang, W.; Wang, Y.; Zhan, R.; Qian, R.; Hu, Q.; Huang, J.
10.1101/2025.06.12.659183 — biophysics — Posted on 2025-06-17
1587 Nanopore Sequencing Unveils Somatic Structural Variations as Biomarkers in Laryngeal squamous cell carcinoma Genomes
Liu, X.; Xia, L.; Qiao, Y.; Li, Y.; Huang, Y.; Yue, B.; Liang, X.; Yang, X.; Zhang, H.; Zhang, J.; Chen, X.; Xie, D.; Liu, J.
10.1101/2025.06.12.659252 — bioinformatics — Posted on 2025-06-17
1588 On-skin, micro-lens enabled camera module for speckle contrast optical spectroscopy/tomography
Quiroga Soto, A. F.; Cortese, L.; Verma, M.; Dannberg, P.; Tachtsidis, I.; Danz, N.; Durduran, T.
10.1101/2025.06.12.659250 — bioengineering — Posted on 2025-06-17
1589 Every Piece of the Puzzle Matters: A Novel Zinc-Binding Site in the Luminal Domain of STIM1 Drives Clustering
Alary, B.; Baksheeva, V. E.; Beaumier, S.; Ferracci, G.; Villard, C.; Golovin, A. V.; Courrier, S.; Devred, F.; Bartoli, M.; Tsvetkov, P. O.
10.1101/2025.06.12.659323 — biochemistry — Posted on 2025-06-17
1590 Predisposed and learned preferences for multipoint visual statistics in visually naïve newly hatched chicks
Zanon, M.; Lemaire, B. S.; Piasini, E.; Caramellino, R.; Nallet, C.; Balasubramanian, V.; Gervain, J.; Zoccolan, D.; Vallortigara, G.
10.1101/2025.06.16.659971 — animal behavior and cognition — Posted on 2025-06-17
1592 Comparative genomics reveals multipartite genomes undergoing loss in the fungal endosymbiotic genus Mycetohabitans
Abbot, B.; Field, S.; Carneal, L.; White, R. A.; Buchan, A.; West, C.; Lee, L.; Carter, M. E.
10.1101/2025.06.12.659383 — genomics — Posted on 2025-06-17
1596 Single oocyte full-length isoform sequencing unveils the impact of transposable elements on RNA diversity and stability during oocyte maturation
Wang, Y.; Wang, W.; Liu, Y.; He, Y.; Song, H.; Yang, M.; Wang, N.; Wang, X.; Ding, L.; Kuo, Y.; Xiu, Y.; Du, Z.; Chen, L.; Lian, Y.; Liu, Q.; Yan, L.; Qiao, J.; Yuan, P.
10.1101/2025.06.17.659919 — developmental biology — Posted on 2025-06-17
1597 The Chromatin Remodeler Protein CHD4 Cooperates With NKX2.2 to Regulate Pancreatic Beta Cell Integrity
Sarbaugh, D. K.; Oliveira, T. G.; Guney, M. A.; Hoelscher, V. M.; Hill, C. J.; Michel, C. R.; Wells, K. L.; Benninger, R. K.; Sussel, L.
10.1101/2025.06.16.659956 — developmental biology — Posted on 2025-06-17
1599 YAP1 and QSER1 are Key Modulators of Embryonic Signaling Pathways in the Mammalian Epiblast
Abraham, E.; Roule, T.; Douglas, A.; Megill, E.; Pericak, O. M.; Howe, J. E.; Choya-Foces, C.; Garbincius, J. F.; Cohen, H. M.; Roig, P.; Zubillaga, M.; Andrake, M. D.; Kim, S.; Elrod, J. W.; Akizu, N.; Estaras, C.
10.1101/2025.06.16.659935 — developmental biology — Posted on 2025-06-17
1601 Transient recurrent dynamics shape representations in mice
Schutzeichel, L.; Bauer, J.; Bouss, P.; Musall, S.; Dahmen, D.; Helias, M.
10.1101/2025.06.17.659440 — neuroscience — Posted on 2025-06-17
1602 Lysergic Acid Diethylamide extends lifespan in Caenorhabditis elegans
Carrilho, B. d. S.; Silva, A. D.; Sant Anna, A. M. K.; Ventura, M. A. V. d. C.; Moll, F. T.; Aguilaniu, H.; Domith, I.; Rehen, S. K.
10.1101/2025.06.16.659936 — neuroscience — Posted on 2025-06-17
1604 Innervation and cargo-specific axonal transport impairments in FUS-ALS mice with gain and loss of function
Simkin, R. L.; Tosolini, A. P.; Mikheenko, A.; Ule, A. M.; Kalmar, B.; Ahmed, M.; Lang, Q.; Lirot, F.; McLaughlin, M. F.; Price, G.; Villarroel-Campos, D.; Greensmith, L.; Sleigh, J. N.; Cunningham, T. J.; Schiavo, G.; Fisher, E. M.; Fratta, P.; Birsa, N.
10.1101/2025.06.16.659513 — neuroscience — Posted on 2025-06-17
1606 Developing a Sensory Representation of an Artificial Body Part
Dowdall, L.; Molina-Sanchez, M.; Dominijanni, G.; da Silva, E.; Pavalkyte, V.; Jugovic, E.; Bianchi, M.; Iida, F.; Clode, D.; Makin, T. R.
10.1101/2025.06.16.658246 — neuroscience — Posted on 2025-06-17
1609 Alcohol consumption drives sex- and region- specific disruption of somatostatin signaling in mice
Brockway, D. A.; Griffith, K.; Kacala, A.; Bellfy, L.; Seemiller, L.; Ullrich, M.; Ricotta, J.; Hossain, M. S.; Kwapis, J. L.; Drew, P. J.; Crowley, N. A.
10.1101/2025.06.16.659907 — neuroscience — Posted on 2025-06-17
1610 Assessing the degree of cortical dislamination through electrical pattern analysis
Aquiles, A.; Pinedo-Vargas, L.; Luna-Munguia, H.; Pena-Ortega, F.; Concha, L.; Rossi-Pool, R.
10.1101/2025.06.16.659942 — neuroscience — Posted on 2025-06-17
1613 Rapid identification of Biomphalaria spp. and diagnosis of Schistosoma mansoni infestation using MALDI-TOF mass spectrometry
Sy, D.; Almeras, L.; Diarra, A. Z.; Doucoure, S.; Sarr, Y. M.; L'Ollivier, C.; Gaye, P. M.; Ndiaye, P. I.; Senghor, B.; Sow, D.; Sokhna, C.; Ranque, S.
10.1101/2025.06.16.659835 — zoology — Posted on 2025-06-17
1616 KRAS withdrawal in Cholangiocarcinoma leads to immune infiltration and tumor regression
Qiao, Y.; Yee, M.; Parikh, C. N.; Cao, Y.; Shih, Y.-H.; Ma, B.; Wu, J. Q.; Ruscetti, M.; Liang, S.-Q.; Xue, W.
10.1101/2025.06.11.659210 — cancer biology — Posted on 2025-06-17
1617 The bacterial ESCRT-III PspA rods thin lipid tubules and increase membrane curvature through helix α0 interactions
Hudina, E.; Schott-Verdugo, S.; Junglas, B.; Kutzner, M.; Ritter, I.; Hellmann, N.; Schneider, D.; Gohlke, H.; Sachse, C.
10.1101/2025.06.13.659447 — biophysics — Posted on 2025-06-17
1618 Deepening imaging-based spatial proteomics at high spatial resolution through controlled tissue resizing and in-situ bottom-up mass spectrometry
Deng, K.; Zhan, L.; Yi, L.; Zhang, J.; Tang, M.; Chang, T.; Ji, G.; Shao, X.; Xu, X.; Wei, X.; Zhang, T.; Yao, J.; Wang, J.; Wang, G.; Huang, Y.
10.1101/2025.06.12.659329 — biophysics — Posted on 2025-06-17
1619 A modular, immunopeptidogenomic (iPepGen) analysis pipeline for discovery, verification, and prioritization of cancer peptide neoantigen candidates
Mehta, S.; Wagner, R.; Do, K. T.; Johnson, J. E.; Yu, F.; Jubenville, T.; Richards, K.; Coleman, S.; Popescu, F. E.; Nesvizhskii, A. I.; Largaespada, D. A.; Jagtap, P. D.; Griffin, T. J.
10.1101/2025.04.07.647596 — bioinformatics — Posted on 2025-06-17
1621 A statistical framework for inferring genetic requirements from embryo-scale single-cell sequencing experiments
Duran, M.; Barkan, E. R.; Tresenrider, A.; Lee, H.; Friedman, R. Z.; Lammers, N.; Colon, M.; Franks, J.; Ewing, B.; Kimelman, D.; Trapnell, C.
10.1101/2025.04.03.646654 — bioinformatics — Posted on 2025-06-17
1628 CRISPR with Transcriptional Readout reveals influenza transcriptionis modulated by NELF and can precipitate an interferon response
Vicary, A. C.; Jordan, S. N. Z.; Mendes, M.; Swaminath, S.; Castro, L. K.; Porter, J. S.; Vo, K. D.; Russell, A. B.
10.1101/2024.11.14.623683 — molecular biology — Posted on 2025-06-17
1629 Processing and release of the maize phytocytokine Zip1
Koenig, M.; Sorger, Z.; Mantz, M.; Perrar, A.; Huesgen, P. F.; Stael, S.; Villamil, J. C. M.; Doehlemann, G.
10.1101/2025.06.11.659102 — plant biology — Posted on 2025-06-17
1632 Plasminogen activator inhibitors orchestrate the immunosuppressive tumor microenvironment in pancreatic cancer
Falcomata, C.; Nielsen, S. R.; Schaefer, M. M.; Singh, B.; Tepper, A.; Chhamalwan, D.; Potak, H. T.; Dhainaut, M.; Mollaoglu, G.; Park, M. D.; Merad, M.; Baccarini, A.; Brown, B. D.
10.1101/2025.06.11.659098 — cancer biology — Posted on 2025-06-17
1633 OnCorr: A pan-cancer mRNA-protein correlation tool for precision oncology
Nawaz, U.; Deng, N.; Livson, O.; Mayoh, C.; Lau, L. M.; Reddel, R. R.; Padhye, B.; Poulos, R. C.
10.1101/2025.06.12.659426 — cancer biology — Posted on 2025-06-17
1634 LINE-1 ORF1p is a shared and immunogenic antigen in cancer
McKerrow, W.; Snyder, M.; Chu, C.; Qadir, D.; Keilhack, H.; Diao, L.
10.1101/2025.06.11.659092 — cancer biology — Posted on 2025-06-17
1640 High-Capacity transcranial Direct Current Stimulation (HC-tDCS)
Donnery, K.; FallahRad, M.; Khadka, N.; Saw, M.; Babaev, B.; Osorio, S.; Koochesfahani, M. B.; Bhuiyan, R.; Elwassif, J. M.; Bikson, M.
10.1101/2025.06.11.659142 — bioengineering — Posted on 2025-06-17
1641 Seahorse Metabolic Analysis for Human and Mouse Cardiac Organotypic Slices
Trampel, K. A.; Li, B.; Melisova, A.; Madrid, M. K.; George, S. A.; Efimov, I. R.
10.1101/2025.06.11.659150 — bioengineering — Posted on 2025-06-17
1642 Spatio-temporal chromosomal arrangements by late-replicating heterochromatin
Polisetty, S. D.; Dutta, S.; Vadnala, R. N.; Padinhateeri, R.; Notani, D.; Sanyal, K.
10.1101/2025.06.12.659004 — genomics — Posted on 2025-06-17
1643 Genomes of the Golden Horde Elites and their Implications for the Rulers of the Mongol Empire
Askapuli, A.; Kanzawa-Kiriyama, H.; Kakuda, T.; Kassenali, A.; Yessen, S.; Schamiloglu, U.; Schrodi, S. J.; Hawks, J.; Saitou, N.
10.1101/2025.06.11.659160 — genomics — Posted on 2025-06-17
1646 Terrigenous inputs link nutrient dynamics to microbial communities in a tropical lagoon
John, C.; Silbiger, N. J.; Adam, T. C.; Barnas, D. M.; Bistolas, K. S.; Carpenter, R. C.; Castaneda, N.; Donahue, M. J.; Donovan, M. K.; Enright, L. N.; Epstein, H. E.; Gallagher, J. P.; Jorissen, H.; Kerlin, J. R.; Leidholt, S. L.; McLachlan, R. H.; Molina, N.; Mullenmeister, C. A.; Neumann, K.; Renzi, J. J.; Silva, D. P.; Speare, K. E.; Swift, S.; Vompe, A. D.; Kelly, L. W.; Zeff, M.; Nelson, C. E.; Thurber, R. V.; Burkepile, D. E.
10.1101/2025.06.11.659169 — ecology — Posted on 2025-06-17
1647 Maternal exercise rescues fetal akinesia-impaired joint and bone development
Panebianco, C. J.; Huang, Y.; Khatib, N.; Gottlieb, D. C.; Essaidi, M.; Ahmed, S.; Dyment, N.; Simmons, R. A.; Boerckel, J. D.; Nowlan, N.
10.1101/2025.06.17.660083 — developmental biology — Posted on 2025-06-17
1651 Tertiary and quaternary structure remodeling by occupancy of the substrate binding pocket in a large glutamate dehydrogenase
Lazaro, M.; Chamorro, N.; Lopez-Alonso, J. P.; Charro, D.; Rasia, R. M.; Jimenez-Oses, G.; Valle, M.; Lisa, M.-N.
10.1101/2024.12.26.630402 — molecular biology — Posted on 2025-06-17
1652 Selective inhibition of MR1-restricted T cell activation by a novel MR1-targeting nanobody
Bates, T. A.; Kulicke, C. A.; Gurmessa, S.; Kim, S.-J.; Suresh, S.; Weinstein, J. R.; Hinchliff, A.; Burke, J. E.; Lewinsohn, D.; Tafesse, F. G.
10.1101/2025.06.11.659204 — immunology — Posted on 2025-06-17
1653 Prevalence of Heartwater in Guadeloupe (2024): Stable endemicity and Evidence of Spread to Les Saintes
Dufleit, V.; Guerrini, L.; Dhune, M.; Viry, L.; Belfort, A.; Jacquet-Cretides, L.; Deddy, J.; Cozier, J.; Naves, M.; Arthein, L.; Sammut, T.; Pezeron, M.; Rodrigues, V.; MEYER, D. F.; Etter, E.
10.1101/2025.06.11.659135 — immunology — Posted on 2025-06-17
1654 Murine peritoneal macrophages undergo female-specific remodeling with aging
Lu, R. J.; Chen, S.; Kim, M.; Sampathkumar, N. K.; Lee, E. H.; Christensen, A.; Wang, E. E.; Lau, I. Y.; Parihar, S.; Ravikumar, C. K.; Jung, J.; Brown, S. B.; Xu, A.; Alvarenga, J. L.; Mehalko, K.; Lee, C. D.; Goodridge, H. S.; Benayoun, B. A.
10.1101/2025.06.11.659200 — immunology — Posted on 2025-06-17
1655 VAMP7-dependent mitochondria-lysosome contacts regulate glial mitochondrial dynamics and dopaminergic neuron survival
Wang, H.; Wang, M.; Tsai, Y.-T.; Cheng, Y.-H.; Lin, Y.-T.; Lin, C.-C.; Lee, Y.-H.; Wang, L.; Yi, S.; Zhang, S.; Pan, Y.; Ho, M. S.
10.1101/2021.08.16.456582 — neuroscience — Posted on 2025-06-17
1656 Evolutionary Convergence of the Arcuate Fasciculus in Marmosets and Humans
Wang, Y.; Cheng, L.; Li, D.; Lu, Y.; Hopkins, W.; Sherwood, C.; Xu, T.; Liu, C.; Paxinos, G.; Jiang, T.; Chu, C.; Fan, L.
10.1101/2025.04.21.649746 — neuroscience — Posted on 2025-06-17
1661 Verification and reproducible curation of the BioModels repository
Smith, L. P.; Malik-Sherif, R. S.; Nguyen, T. V. N.; Hermjakob, H.; Karr, J.; Shaikh, B.; Drescher, L.; Moraru, I. I.; Schaff, J.; Agmon, E.; Patrie, A.; Blinov, M. L.; Hellerstein, J.; May, E.; Nickerson, D.; Gennari, J.; Sauro, H.
10.1101/2025.01.16.633337 — systems biology — Posted on 2025-06-17
1662 Klotho deficiency promotes skeletal muscle weakness and is associated with impaired motor unit connectivity
Bean, L. A.; Thomas, C.; Villa, J. F.; Fitt, A. J.; Javier, A. J.; Agrawal, A.; Whitney, H.; Dos Santos, G. N.; White, K. E.; Huot, J. R.; Welc, S. S.
10.1101/2025.06.11.659129 — physiology — Posted on 2025-06-17
1671 Prolonged cell encapsulation and rapid filamented light biofabrication of muscle constructs in microgravity
Winkelbauer, M.; Janiak, J.; Windisch, J.; Liu, H.; Bulatova, M.; Witzleben, M. W.; Oliveira, H.; Dani, S.; Richter, R. F.; L'Heureux, N.; Bar-Nur, O.; Gelinsky, M.; Zenobi, M.; Chansoria, P.
10.1101/2025.06.11.659059 — bioengineering — Posted on 2025-06-17
1674 The contribution of native protein complexes to targeted protein degradation
Glennie, L.; Curnutt, N.; Cartwright, T.; Dunbar, K. J.; Chatelier, B. L.; Wood, N.; Macartney, T. J.; Woo, C. M.; Sapkota, G. P.
10.1101/2025.06.17.660125 — cell biology — Posted on 2025-06-17
1675 Endothelial Cells retain inflammatory memory through chromatin remodeling
Gonsales Spindola, D.; Clark, S.; Bahr, A.; Pin de Jesus, G.; Martino, N.; Lowery, A. M.; Lyu, S.; Seeman, A.; Martino, G.; Albeche Duarte, G.; Crosbourne, E.; Vincent, P.; MacNamara, K. C.; Adam, A. P.; Bossardi Ramos, R.
10.1101/2025.06.12.659136 — cell biology — Posted on 2025-06-17
1676 Mapping the soil microbiome functions shaping wetland methane emissions
Borton, M. A.; Oliverio, A. M.; Narrowe, A. B.; Villa, J. A.; Rinke, C.; Hoyt, D. W.; Liu, P.; McGivern, B. B.; Bechtold, E. K.; Ellenbogen, J. B.; Daly, R. A.; Smith, G. J.; Angle, J. C.; Flynn, R. M.; Freiburger, A. P.; Louie, K. B.; Stemple, B.; Northen, T.; Henry, C.; Miller, C.; Morin, T. H.; Bohrer, G.; Wrighton, K. C.
10.1101/2024.02.06.579222 — microbiology — Posted on 2025-06-17
1677 DEVELOPMENT OF A POTENT MONOCLONAL ANTIBODY FOR TREATMENT OF HUMAN METAPNEUMOVIRUS INFECTIONS
Harris, E. D.; McGovern, M.; Pernikoff, S.; Ikeda, R.; Kipnis, L.; Hannon, W.; Sobolik, E. B.; Gray, M.; Greninger, A. L.; He, S.; Chin, C.-N.; Fu, T.-M.; Pancera, M.; Boonyaratanakornkit, J.
10.1101/2025.06.09.657676 — immunology — Posted on 2025-06-17
1680 Osteoarthritic chondrocytes exert higher contractile forces and exhibit enhanced protrusive activity when cultured in 3D degradable hydrogels
Vovchenko, M.; Vaes, N.; Barrasa-Fano, J.; Shapeti, A.; Castro Vinuelas, R.; Kimps, L.; Glorieux, C.; Jonkers, I.; Van Oosterwyck, H.
10.1101/2025.02.27.640613 — bioengineering — Posted on 2025-06-17
1681 RhoA Allosterically Activates Phospholipase Cε via its EF Hands
Ohri, V.; Samassekou, K.; Muralidharan, K.; Garland-Kuntz, E. E.; Fisher, I. J.; Hogan, W. C.; Davis, B. M.; Lyon, A.
10.1101/2024.11.14.623250 — biochemistry — Posted on 2025-06-17
1683 Interindividual variability in flower pickiness by foraging bumblebees
Armand, M.; Beckenbauer, C.; Avargues-Weber, A.; Lihoreau, M.; Czaczkes, T. J.
10.1101/2024.12.19.629386 — animal behavior and cognition — Posted on 2025-06-17
1684 Loss of Bbs8 leads to cystic kidney disease in mice with reduced acetylation of ciliary alpha-tubulin through HDAC2
Kieckhoefer, E.; Guenzler, J.; Matthiessen, P. A.; Ebert, L. K.; Klausen, C.; Wachten, D.; Cetiner, M.; Liebau, M. C.; Benzing, T.; May-Simera, H. L.; Schermer, B.
10.1101/2024.03.07.583949 — genetics — Posted on 2025-06-17
1692 A Multiscale Framework for Uncovering Surfactant Mediated Viral Capsid Disruption
Masirevic, S.; Marzinek, J. K.; Kong, M. L. Y.; Lin, G.; Chen, H.; Liu, J.; Chua, C.; Maupin, C. M.; Verma, C. S.; Fox, S. J.; Bond, P. J.
10.1101/2025.06.16.659739 — biophysics — Posted on 2025-06-17
1693 Human parainfluenza virus infection remodels the host cell glycome
Das, P. K.; Dirr, L.; Bailly, B.; Guillon, P.; Everest-Dass, A.; von Itzstein, M.
10.1101/2025.06.15.659808 — microbiology — Posted on 2025-06-17
1694 Molecular and Phenotypic Characterization of Telomere Repeat Binding (TRBs) Proteins in Moss: Evolutionary and Functional Perspectives
Kusova, A.; Hola, M.; Goffova Petrova, I.; Rudolf, J.; Zachova, D.; Skalak, J.; Hejatko, J.; Klodova, B.; Prerovska, T.; Lycka, M.; Sykorova, E.; Bertrand, Y. J. K.; Fajkus, J.; Honys, D.; Prochazkova Schrumpfova, P.
10.1101/2025.06.11.659030 — plant biology — Posted on 2025-06-17
1695 Molecular Insights into the Production of Extracellular Vesicles by Plants
Koch, B. L.; Gardner, D.; Smith, H.; Bracewell, R.; Awdey, L.; Foster, J.; Borniego, M. L.; Munch, D. H.; Nielsen, M. E.; Pasupuleti, R.; Trinidad, J.; Rutter, B.; Thordal-Christensen, H.; Innes, R. W.
10.1101/2025.06.16.659989 — plant biology — Posted on 2025-06-17
1697 The NLR immune receptor Roq1 recognizes the Pseudomonas syringae HopAG1 effector via its Nudix domain
Gorecka, M.; Jonak, M.; Grech-Baran, M.; Steczkiewicz, K.; Ochoa, J. C.; Krepski, T.; Zembek, P. B.; Pawłowski, K.; Krzymowska, M.
10.1101/2025.06.13.659573 — plant biology — Posted on 2025-06-17
1700 A robust platform for recombinant production of animal venom toxin modulators of ion channels
Gonzalez-Prada, J. E.; Haworth, A.; Browne, J.; Salvage, S. C.; Secomandi, N.; Rush, A.; Ritoux, A.; Dannawi, M.; Lee, L.; Mavridou, V.; Dong, Y. Y.; Smith, E. S. J.; Jackson, A.; Stevens, E.; Miller, P. S.
10.1101/2025.06.11.659050 — pharmacology and toxicology — Posted on 2025-06-17
1701 Does crossing the pond affect crystal quality?
Campomizzi, C. S.; Snell, M. E.; Mikolajek, H.; Sandy, J.; Sanchez-Weatherby, J.; Budziszewski, G. R.; Russi, S.; Howells, R.; Cohen, A.; Hough, M. A.; Bowman, S. E. J.
10.1101/2025.06.12.659325 — biophysics — Posted on 2025-06-17
1705 PHD1-dependent hydroxylation of RepoMan (CDCA2) on P604 modulates the control of mitotic progression
Druker, J.; Jiang, H.; Shakir, D.; Child, F.; Alvarez, V.; Platani, M.; Corno, A.; Alabert, C.; Saurin, A. T.; Swedlow, J. R.; Rocha, S.; Lamond, A. I.
10.1101/2025.05.06.652400 — cell biology — Posted on 2025-06-17
1707 Vertebrate Biodiversity via eDNA at the air-water interface
Ip, Y. C. A.; Brandao-Dias, P. F. P.; Guri, G.; Allan, E. A.; Kelly, R. P.
10.1101/2025.06.13.659655 — molecular biology — Posted on 2025-06-17
1708 Type-I interferon priming signal balances anti-bacterial and anti-tumor trained immunity in alveolar macrophages
Wang, T.; Zhang, J.; Miao, Y.; Wang, Y.; Li, Y.; Wang, L.; Liu, Y.; Chang, C.-W.; Chen, E.; Yao, Y.
10.1101/2025.06.14.659659 — immunology — Posted on 2025-06-17
1711 AI-Guided CAR Designs and AKT3 Degradation Synergize to Enhance Bispecific and Trispecific CAR-T Cell Persistence and Overcome Antigen Escape
Ansari, M. S.; Chauhan, V.; Singh, A.; Akhtar, A.; Chaudhary, N.; Tyagi, R.; Divya, ; Husain, K.; Sharma, S.; Alam, R.; Md Shakir, ; Pracha, M.; Anjum, S.; Mohd Nadeem, ; Faizan, M. I.; Azmi, I.; Iyer, A. R.; Gupta, P.; Nafiz, M.; Ali, S.; Ud din, I. M.; Javid, M.; Kuma P, H.; Srivastava, A. K.; Mabalirajan, U.; Mathews, V.; Ramalingam, S.; Kharya, G.; Ahmad, T.
10.1101/2025.06.12.658477 — cancer biology — Posted on 2025-06-17
1712 Early initiation of small intestine neuroendocrine tumors
Schiller, A.; Hultmark, A.; Lindberg, M.; Socratous, A.; Luijts, T.; Van den Eynden, J.; Elf, A.-K.; Rossi Norrlund, R.; Arvidsson, Y.; Elias, E.; Larsson, E.
10.1101/2025.05.16.654489 — cancer biology — Posted on 2025-06-17
1713 Transient Non-local Interactions Dominate the Dynamics of Measles Virus NTAIL
Otteson, L.; Nagy, G.; Kunkel, J.; Kodis, G.; Bock, L. V.; Bignon, C.; Longhi, S.; Zheng, W.; Grubmüller, H.; Vaiana, A. C.; Vaiana, S. M.
10.1101/2024.07.22.604679 — biophysics — Posted on 2025-06-17
1716 REINDEER2: practical abundance index at scale
Hernandez-Courbevoie, Y.; Salson, M.; Bessiere, C.; Yue, H.; Gautheret, D.; Marchet, C.; Limasset, A.
10.1101/2025.06.16.659990 — bioinformatics — Posted on 2025-06-17
1720 Plastic-Degrading Clusters of Orthologous Groups in Prokaryotes
Mustari, S.; Pham, L. T.; Saikkonen, K.; Nakamura, M.; Puigbo, P.
10.1101/2025.06.10.658834 — microbiology — Posted on 2025-06-17
1722 Senescence-Associated Chromatin Rewiring Promotes Inflammation and Transposable Element Activation
Dalgarno, A.; Evans, S. A.; Kelsey, M. M. G.; Nunez, T. A.; Rocha, A.; Clark, K.; Sedivy, J. M.; Neretti, N.
10.1101/2025.06.11.659151 — genomics — Posted on 2025-06-17
1724 M. tuberculosis meets European Lead Factory - identification and structural characterization of novel Rv0183 inhibitors using X-ray crystallography
Riegler-Berket, L.; Goedl, L.; Polidori, N.; Aschauer, P.; Grininger, C.; Prosser, G.; Lichtenegger, J.; Sagmeister, T.; Parigger, L.; Gruber, C. C.; Reiling, N.; Oberer, M.
10.1101/2025.06.12.659322 — biochemistry — Posted on 2025-06-17
1725 A general framework for cycles in ecology
Calleja Solanas, V.; Moura, R. O.; Langa, J. A.; Portillo Fernandez, J. R.; Soler-Toscano, F.; Godoy, O.
10.1101/2025.01.13.632680 — ecology — Posted on 2025-06-17
1726 CCDC32 stabilizes clathrin-coated pits and drives their invagination
Yang, Z.; Yang, C.; Huang, Z.; Xu, P.; Li, Y.; Han, L.; Peng, L.; Wei, X.; Pak, J.; Svitkina, T.; Schmid, S. L.; Chen, Z.
10.1101/2024.06.26.600785 — cell biology — Posted on 2025-06-17
1729 Multi-omics investigation of spontaneous T2DM macaque reveals gut microbiota promote T2DM by up-regulating the absorption of excess palmitic acid
Liu, X.; Yang, S.; Xie, Y.; Jiang, C.; Shang, K.; Luo, J.; Zhang, L.; Hu, G.; Liu, Q.; Yue, B.; Fan, Z.; He, Z.; Li, J.
10.1101/2024.10.17.618794 — microbiology — Posted on 2025-06-17
1730 Napping alters Functional Brain Responses in the Aged
Reyt, M.; Dourte, M.; DeHaan, S.; Deantoni, M.; Baillet, M.; Lesoinne, A.; Laloux, S.; Hammad, G.; Collette, F.; Peigneux, P.; Muto, V.; Vandewalle, G.; Bahri, M. A.; Phillips, C.; Schmidt, C.
10.1101/2025.06.10.657597 — neuroscience — Posted on 2025-06-17
1735 Patch deconvolution for Fourier light-field microscopy
Fu, B.; Jones, C. L.; Heraghty, D.; Yang, S.; O'Brien-Ball, C.; Junghans, V.; Yang, H.; Knowles, T.; Weiss, L. E.; Fernandes, R. A.; Lee, S.
10.1101/2025.06.13.659385 — biophysics — Posted on 2025-06-17
1737 Pulsed-laser lensing for phase modulation in electron microscopy
Du, D. X.; Bartnik, A. C.; Duncan, C. J. R.; Choudhry, U.; Tabachnik, T.; Sallah, C.; Ogawa, Y.; Najafi, E.; Yang, D.-S.; Maxson, J. M.; Fitzpatrick, A. W. P.
10.1101/2025.06.12.659428 — biophysics — Posted on 2025-06-17
1743 Atad3 is Essential for Mitochondrial Permeability Transition Pore Opening and Cardiac Ischemia Reperfusion Injury.
Robichaux, D.; Lopez, S. J.; Mendoza, A.; Ramirez, D.; Lin, S.-C. J.; Molkentin, J. D.; Peixoto, P. M.; Karch, J. M.
10.1101/2025.06.13.658955 — cell biology — Posted on 2025-06-17
1745 Sex-specific recombination landscape in a species with holocentric chromosomes
Chmielewski, S.; Konczal, M.; Parrett, J. M.; Rombauts, S.; Dudek, K.; Radwan, J.; Babik, W.
10.1101/2024.04.15.589577 — genomics — Posted on 2025-06-17
1749 Conserved interfaces mediate multiple protein-protein interactions in a prokaryotic metabolon
Bhattacharyya, S.; Ranganathan, S.; Chowdhury, S.; ADKAR, B. V.; Khrapko, M.; Shakhnovich, E.
10.1101/2024.02.17.580827 — biophysics — Posted on 2025-06-17
1750 WaveSeekerNet: Accurate Prediction of Influenza A Virus Subtypes and Host Source Using Attention-Based Deep Learning
Nguyen, H.-H.; Rudar, J.; Lesperance, N.; Vernygora, O.; Taylor, G. W.; Laing, C.; Lapen, D.; Leung, C. K.; Lung, O.
10.1101/2025.02.25.639900 — bioinformatics — Posted on 2025-06-17
1756 Multi-omics analysis uncovers differential growth kinetics of Japanese Encephalitis Virus in human and porcine macrophages
Praharaj, M. R.; Ambati, T.; Kumar, S.; Gulati, B. R.; Majumdar, S. S.; Sharma, G. T.; Dey, B.; Gandham, R. K.
10.1101/2025.06.16.659876 — microbiology — Posted on 2025-06-16
1760 Integrating eDNA and acoustic-trawl data to provide small pelagic biomass estimates for fisheries assessment
Claver, C.; Sobradillo, B.; Mendibil, I.; Canals, O.; Boyra, G.; Ibaibarriaga, L.; Kelly, R. P.; Rodriguez-Ezpeleta, N.
10.1101/2025.06.11.659118 — genetics — Posted on 2025-06-16
1762 In cellulo DNA assembly for targeted genomic integration and rearrangement in human cells
Levesque, S.; Kawashima, N.; Hwang, G.-H.; Becerra, B.; Schoonenberg, V. A.; Mannherz, W.; Homfeldt, L.; Pinello, L.; Agarwal, S.; Bauer, D. E.
10.1101/2025.06.16.659926 — molecular biology — Posted on 2025-06-16
1763 Real-time Malaria Detection in the Amazon Rainforest via Drone-Collected eDNA and Portable qPCR
Ip, Y. C. A.; Montemartini, L.; Chang, J. J. M. Y. C.; Desiderato, A.; Franco-Sierra, N. D.; Geckeler, C.; Gonzalez, M. A.; Gregorini, M.; Jucker, M.; Kirchgeorg, S.; Luthi, M.; Thostrup, F. B.; Murari, G.; Mura, M.; Santacruz, P. P.; Sangermano, F.; Schindler, T.; Melvad, C.; Mintchev, S.; Deiner, K.
10.1101/2025.06.16.660023 — molecular biology — Posted on 2025-06-16
1764 Stress testing reveals selective vulnerabilities in protein homeostasis
Aldikacti, B.; Putun, H.; Sarsani, V.; Zeinert, R.; Flaherty, P.; Chien, P.
10.1101/2025.06.11.659168 — molecular biology — Posted on 2025-06-16
1765 Transgenic Inducible MHC I Overexpression in Mouse Alveolar Type 2 Cells
Mathe, J.; Brochu, S.; Saba-El-Leil, M. K.; Cote, C.; Karia, A.; Harton, S.; Perreault, C.
10.1101/2025.06.11.659140 — molecular biology — Posted on 2025-06-16
1767 A novel AAA+ ATPase required for sporulation and stress response in Bacillus anthracis
Sangwan, N.; Bothra, A.; Pomerantsev, A. P.; Gangwal, A.; Fattah, R.; Moayeri, M.; Ma, Q.; Ganesan, S.; Keshavam, C. C.; Baweja, R.; Dhawan, U.; Leppla, S. H.; Singh, Y.
10.1101/2025.06.16.659970 — microbiology — Posted on 2025-06-16
1770 Genome-wide CRISPR base-editing screening defines drug response networks in Leishmania
del Angel, J. A.; Link, F.; May, N. H.; Ekici, I.; Wawra, K.; Schwind, S.; Zorn, S.; Haggarty, J.; Weidt, S. K.; Ritchie, R.; Barrett, M. P.; van Zandbergen, G.; Beneke, T.
10.1101/2025.06.16.659792 — microbiology — Posted on 2025-06-16
1771 Biosynthesis of glycosylated 5-hydroxycytosine in the DNA of diverse viruses
Lee, Y.-J.; Li, J.; Sobieski, C.; Young, S. H.; Stupak, J.; Vinogradov, E.; Zhou, H.; Chen, W.; Weigele, P.; Peters, D. L.
10.1101/2025.06.16.659550 — microbiology — Posted on 2025-06-16
1773 Bacteriophage diversity declines with COPD severity in the respiratory microbiome
Cook, R. A.; Ponsero, A. J.; Telatin, A.; Yang, Y.; Liang, Z.; Wang, F.; Chen, R.; Wang, Z.; Adriaenssens, E. M.; Clokie, M. R.; Millard, A. D.; Brightling, C. E.
10.1101/2025.06.16.659870 — microbiology — Posted on 2025-06-16
1775 The Spatial Atlas of Human Anatomy (SAHA): A Multimodal Subcellular-Resolution Reference Across Human Organs
Park, J.; De Gregorio, R.; Hissong, E.; Ozcelik, E.; Bartelo, N.; Dezem, F. S.; Zhang, L.; Marcao, M.; DuBose, H.; Zheng, Y.; Abila, E.; Kim, J.; Proszynski, J.; Agyemang, A. A.; Arikatla, M. R.; Metzger, E.; Rogers, S.; Divakar, P.; Dulai, P. S.; Reeves, J. W.; Liang, Y.; Pan, L.; Bhattacharjee, S.; Young, K.; Heck, A.; Korukonda, M.; McGuire, D.; Wu, L.; Wardhani, A.; Beechem, J.; Church, G.; Lipkin, S. M.; Patel, S.; Socciarelli, F.; Monette, S.; Robinson, B.; Loda, M.; Elemento, O.; Martelotto, L.; Plummer, J. T.; Rendeiro, A. F.; Alonso, A.; Schwartz, R. E.; Houlihan, S. L.; Mason, C. E.
10.1101/2025.06.16.658716 — systems biology — Posted on 2025-06-16
1776 Pathway Sculptor for Compact and Versatile Combinatorial Genetic Perturbation
Gu, B.; Linton, J.; Hendrickson, B. G.; Li, H.; Hadas, R.; Manella, G.; Gregrowicz, J.; Elowitz, M. B.
10.1101/2025.06.15.659618 — synthetic biology — Posted on 2025-06-16
1777 A synthetic cell phage cycle
Levrier, A.; Soudier, P.; Garenne, D.; Izri, Z.; Bowden, S. D.; Lindner, A. B.; Noireaux, V.
10.1101/2025.06.14.659709 — synthetic biology — Posted on 2025-06-16
1779 FvFT1-FvTFL1 epistasis drives flowering time adaptation in woodland strawberry
Lembinen, S.; Koskela, E.; Fan, G.; Toivainen, T.; Zhou, Q.; Andres, J.; Vaattovaara, A.; Rastas, P. M. A.; De Kort, H.; Elomaa, P.; Hytonen, T.
10.1101/2025.06.11.659068 — plant biology — Posted on 2025-06-16
1780 A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance
Karunaraj, P.; Scheele, R.; Wells, M. L.; Rathod, R.; Abrahamson, S.; Taylor, L. C.; Gokulu, I. S.; Chowdhury, L.; Kazmi, A.; Song, W.; Hornbeck, P.; Li, J.; Glasgow, A.; Vasan, N.
10.1101/2025.06.11.659120 — cancer biology — Posted on 2025-06-16
1782 Annotating the X-ray diffraction pattern of vertebrate striated muscle
Koubassova, N. A.; Dutta, D.; Ma, W.; Tsaturyan, A. K.; Irving, T.; Padron, R.; Craig, R.
10.1101/2025.06.11.659175 — biophysics — Posted on 2025-06-16
1786 Structure of a pH-sensitive pentameric ligand-gated ion channel from the Sarcoptes scabies mite
Kleiz-Ferreira, J.; Brams, M.; Harrison, P. J.; Gallagher, C. I.; Nys, M.; Donze, Y.; Quigley, A.; Bertrand, D.; Ulens, C.
10.1101/2025.06.11.659021 — biochemistry — Posted on 2025-06-16
1791 Odoribacter splanchnicus mitigates pathogen-induced gut inflammation and its associated pathogenesis via its secreted bacteriocin
Hajra, D.; Mukherjee, D.; Vij, R.; Rajmani, R. S.; Dadireddy, V.; Das, D.; Hussain, T.; Ganji, M.; Tatu, U.; Chakravortty, D.
10.1101/2024.08.23.609322 — microbiology — Posted on 2025-06-16
1792 The pcnB gene sustains Shigella flexneri virulence
Frisch, T.; Geiser, P.; Komi, M.; Karlsson, P. A.; Bhetwal, A.; Jenniches, L.; Barquist, L.; Holmqvist, E.; Mateus, A.; Sellin, M. E.; Di Martino, M. L.
10.1101/2025.06.16.659909 — microbiology — Posted on 2025-06-16
1793 Dermaseptin DMS-DA6, a promising alternative to conventional antibiotic in the treatment of N. brasiliensis induced actinomycetoma
Auvynet, C.; Ivonne, D.-M. D.; Velia, V.-M. A.; Estefania, A.-N.; Christophe, P.; Yvonne, R.; Cesar, S.-C. M.
10.1101/2025.06.16.659840 — microbiology — Posted on 2025-06-16
1794 Type IV minor pilin ComN predicted the USS-receptor in Pasteurellaceae
Helsem, S. A.; Alfsnes, K.; Frye, S. A.; Hesselberg Lovestad, A. Y.; Ambur, O. H.
10.1101/2025.06.16.659825 — microbiology — Posted on 2025-06-16
1796 Evolutionary Genomics Guides Scalable Coral Probiotics for Climate Resilience
Xie, M.; Xiang, N.; Liao, T.; Cheung, C. T.; Lee, C. H.; Tse, W. Y.; Tsang, K. K.; Ho, K. E.; He, Q.; Dörr, M.; Manns, H.; Li, P.; Xian, Z.; Wang, X.; Luo, D.; Hayden, R.; Chei, E.; Wan, Z.; Thompson, P.; Brennan, J.; Peixoto, R. S.; Cui, G.; Mcllroy, S. E.; Chui, A. P. Y.; Voolstra, C. R.; Luo, H.
10.1101/2025.06.16.659728 — microbiology — Posted on 2025-06-16
1800 Optimising the use of Oxford Nanopore Sequencing technology for detection of Wolbachia bacterial endosymbionts in Anopheles mosquitoes.
Chatterley, L.; Hull, N.; Hughes, I.; Sougoufara, S.; Meek, O.; Ceyran, M.; Dhokiya, V.; Bandibabone, J.; Adala, C.; Cunningham, E.; Awandu, S. S.; Nkondjio, C. A.; Hughes, G. L.; Heinz, E.; Walker, T.
10.1101/2025.06.16.659891 — microbiology — Posted on 2025-06-16
1802 Dual Role of Plasmacytoid Dendritic Cells in Humoral and CD8⁺ T Cell Memory Post COVID-19 mRNA Vaccination
Pizzichetti, C.; Latino, I.; Virgilio, T.; Capucetti, A.; Chahine, K.; Cascione, L.; Moro, S. G.; Brugger, M.; Kozarac, N.; Pulfer, A.; Renner, L.; Thakur, R. S.; Benarafa, C.; Legler, D. F.; Gonzalez, S. F.
10.1101/2025.06.13.659539 — immunology — Posted on 2025-06-16
1804 The cortical scene processing network emerges in infancy, prior to independent navigation experience
Kamps, F. S.; Chen, E. M.; Du, H.; Kosakowski, H. L.; Fuchs, A.; Kanwisher, N.; Saxe, R.
10.1101/2025.06.16.655720 — neuroscience — Posted on 2025-06-16
1807 Selective octopaminergic tuning of mushroom body circuits during memory formation
Franke, U. S.; Grossjohann, A.; Aurich, S.; Köhler, I.; Lamberty, M.; Selcho, M.; Kittel, R. J.; Thum, A. S.; Pauls, D.
10.1101/2025.06.16.659845 — neuroscience — Posted on 2025-06-16
1811 Susceptible host dynamics explain pathogen resilience to perturbations
Park, S. W.; Nielsen, B. F.; Howerton, E.; Grenfell, B.; Cobey, S.
10.1101/2025.06.13.659551 — ecology — Posted on 2025-06-16
1813 Increased listening effort and cochlear neural degeneration underlie speech-in-noise deficits in normal hearing middle-aged adults
Zink, M. E.; Zhen, L.; McHaney, J. R.; Klara, J.; Yurasits, K.; Cancel, V.; Flemm, O.; Mitchell, C.; Datta, J.; Chandrasekaran, B.; Parthasarathy, A.
10.1101/2024.08.01.606213 — neuroscience — Posted on 2025-06-16
1814 Meningeal vascular Aβ deposition associates with cerebral hypoperfusion and compensatory collateral remodeling
Kaloss, A. M.; Browning, J. L.; Li, J.; Pan, Y.; Watsen, S.; Sontheimer, H.; Theus, M. H.; Olsen, M. L.
10.1101/2025.02.05.635937 — neuroscience — Posted on 2025-06-16
1815 Brain FGF2 and NCAM1 contribute to FGFR1-dependent progression of ER+ breast cancer brain metastases in young and aged hosts
Fox, M. S.; Jaramillo-Gomez, J. A.; Marquez-Ortiz, R. A.; Alvarez-Eraso, K. L. F.; Contreras Zarate, M. J.; Koliavas, S.; Kabos, P.; Serkova, N. J.; Sartorius, C. A.; Wellberg, E. A.; Cittelly, D. M.
10.1101/2025.06.07.658373 — cancer biology — Posted on 2025-06-16
1819 Spyglass: a framework for reproducible and shareable neuroscience research
Lee, K. H.; Denovellis, E. L.; Ly, R.; Magland, J.; Soules, J.; Comrie, A. E.; Gramling, D. P.; Guidera, J. A.; Nevers, R.; Adenekan, P.; Brozdowski, C.; Bray, S. R.; Monroe, E.; Bak, J. H.; Coulter, M.; Sun, X.; Broyles, E.; Shin, D.; Chiang, S.; Holobetz, C.; Tritt, A.; Ruebel, O.; Nguyen, T.; Yatsenko, D.; Chu, J.; Kemere, C.; Garcia, S.; Buccino, A.; Frank, L. M.
10.1101/2024.01.25.577295 — neuroscience — Posted on 2025-06-16
1820 Flexible EMG arrays with integrated electronics for scalable electrode density
Anschutz, P. M.; Zia, M.; Lu, J.; Williams, M. J.; Jacob, A. L.; Sober, S. J.; Bakir, M. S.
10.1101/2024.07.02.601782 — neuroscience — Posted on 2025-06-16
1821 Bacterial population dynamics during colonization of solid tumors
Sayin, S.; ElGamel, M.; Rosener, B.; Brehm, M.; Mugler, A.; Mitchell, A.
10.1101/2025.02.11.637537 — systems biology — Posted on 2025-06-16
1824 RpS12-mediated induction of the Xrp1short isoform links ribosomal protein mutations to cell competition
Potiri, M.; Tsakiri, E.; Kontogiannidi, K.; Loizou, M.; Skoulakis, E. M. C.; Samiotaki, M.; Kafasla, P.; Kiparaki, M.
10.1101/2025.06.15.659587 — developmental biology — Posted on 2025-06-16
1825 Diatom ultrastructural diversity across controlled and natural environments
Flori, S.; Mikus, F.; Flaum, E.; Moog, K.; Guessoum, S.; Beavis, T.; Zwahlen, S.; Romero-Brey, I.; Orschot, V.; Olivetta, M.; Steele-Ogus, M.; Yeh, E.; Mobile Labs Team, ; Dudin, O.; Schwab, Y.; Dey, G.; Vincent, F.
10.1101/2025.06.16.659906 — cell biology — Posted on 2025-06-16
1826 Sld3CBD-Cdc45 structural insights into Cdc45 recruitment for CMG complex formation on DNA replication
Li, H.; Ishizaki, I.; Kato, K.; Sun, X.; Muramatsu, S.; Itou, H.; Ose, T.; Araki, H.; Yao, M.
10.1101/2024.08.29.610416 — molecular biology — Posted on 2025-06-16
1827 Virus glycoprotein nanodisc platform for vaccine design
Rantalainen, K.; Liguori, A.; Ozorowski, G.; Flynn, C.; Steichen, J. M.; Swanson, O.; Madden, P. J.; Baboo, S.; Phulera, S.; Gharpure, A.; Lu, D.; Kalyuzhniy, O.; Skog, P.; Terada, S.; Shil, M.; Diedrich, J. K.; Georgeson, E.; Tingle, R.; Eskandarzadeh, S.; Lee, W.-H.; Goodwin, D.; Alavi, N.; Kubitz, M.; Amirzehni, S.; Himansu, S.; Sok, D.; Lee, J. H.; Yates, J. R.; Paulson, J. C.; Crotty, S.; Schiffner, T.; Ward, A. B.; Schief, W. R.
10.1101/2025.05.02.651272 — immunology — Posted on 2025-06-16
1832 Genomic structural equation modeling of impulsivity and risk-taking traits reveals three latent factors distinctly associated with brain structure and development
Shishikura, M.; Liu, L.; Yu, E.; Zhu, R.; Vilar-Ribo, L.; Cupertino, R. B.; Palmer, A. A.; Sanchez-Roige, S.; Vainik, U.; Morys, F.; Gan-Or, Z.; Misic, B.; Dagher, A.
10.1101/2025.06.05.657840 — neuroscience — Posted on 2025-06-16
1836 Paralog interference preserves genetic redundancy
Cisneros, A.; Mattenburger, F.; Gagnon-Arsenault, I.; Seffal, Y.; Nielly-Thibault, L.; Dube, A.; Varela Vasquez, M. d. M.; Munoz Vega, M. C.; Landry, C. R.
10.1101/2025.06.13.659495 — evolutionary biology — Posted on 2025-06-16
1838 Mitotic BLM functions are required to maintain genomic stability
Hamann, T. E.; Wieland, A.; Tirincsi, A.; Vukusic, K.; Mohseni, F.; Wardenaar, R.; Losito, M.; Goenenc, I. I.; Wollnik, B.; Foijer, F.; Tolic, I. M.; Storchova, Z.; Raschle, M.
10.1101/2025.06.16.659902 — cell biology — Posted on 2025-06-16
1839 Ciliary and non-ciliary functions of CEP104 in Xenopus
Louka, P.; Potamiti, L.; Panayiotidis, M. I.; Skourides, P.
10.1101/2025.06.12.659327 — cell biology — Posted on 2025-06-16
1842 Neural sensitivity to radial frequency patterns in the visual cortex of developing macaques
Rodriguez Deliz, C. L.; Lee, G.; Bushnell, B.; Majaj, N.; Movshon, J. A.; Kiorpes, L.
10.1101/2025.01.27.634810 — neuroscience — Posted on 2025-06-16
1843 Catecholamines reduce choice history biases
de Gee, J. W.; Kloosterman, N. A.; Braun, A.; Donner, T. H.
10.1101/2024.10.28.620689 — neuroscience — Posted on 2025-06-16
1844 Multifaceted brain representation of numerosity across the senses and presentation formats
Yang, Y.; Fornaciai, M.; Togoli, I.; Shahzad, I.; Gau, R.; Van Audenhaege, A.; Cerpelloni, F.; Collignon, O.
10.1101/2025.05.29.653470 — neuroscience — Posted on 2025-06-16
1845 Dorsal prefrontal cortex drives perseverative behavior in mice
Lebedeva, A.; Wang, Y.; Funnell, L.; Terry, B.; Oh, J.; Miller, K.; Harris, K. D.
10.1101/2024.05.02.592241 — neuroscience — Posted on 2025-06-16
1849 High-throughput microbiome profiling and co-occurrence with antibiotic resistance genes in Lucilia sericata
Shatta, A.; Chavarria, X.; Choi, J. H.; Oh, S.; Kim, M.; Kang, D.; Cho, Y. H.; Choi, D.-Y.; Yi, M.-h.; Kim, J. Y.
10.1101/2025.06.11.659062 — ecology — Posted on 2025-06-16
1850 The Rab7-Epg5 and Rab39-ema modules cooperatively position autophagosomes for efficient lysosomal fusions
Boda, A.; Balazs, V.; Nagy, A.; Hargitai, D.; Lippai, M.; Simon-Vecsei, Z.; Molnar, M.; Fürstenhoffer, F.; Juhasz, G.; Lörincz, P.
10.1101/2024.08.16.608254 — cell biology — Posted on 2025-06-16
1851 Aiolos restricts the generation of antigen-inexperienced, virtual memory CD8+ T cells
Oestreich, K.; Pokhrel, S.; Jones, D. M.; Leonard, M. R.; Tuazon, J. A.; Read, K. A.; Dileepan, G.; Warren, R. T.; Gong, Q.; Yount, J.; Xin, G.; Forero, A.; Ghoneim, H. E.; Collins, P.; Hemann, E.
10.1101/2025.06.11.659122 — immunology — Posted on 2025-06-16
1853 ACOD1 regulates microglial arginine metabolism and inflammatory responses
Karadima, E.; Yilmaz, C.; Sinha, A.; Fodelianaki, G.; Dimothyra, S.; Nirakis, N.; Traikov, S.; Zamboni, N.; Wielockx, B.; Verginis, P.; Peitzsch, M.; Chavakis, T.; Alexaki, V. I.
10.1101/2025.06.01.657243 — immunology — Posted on 2025-06-16
1854 Elucidating the Contribution of OVLT Glutamatergic Neurons to Mineralocorticoid Hypertension in TASK-/- Mice
Shi, L.; Liu, K.; Zhao, K.; He, W.; Chen, Y.; Zhao, X.; Wei, Y.; Chen, J.; Wang, S.; Yuan, F.
10.1101/2025.06.11.659218 — neuroscience — Posted on 2025-06-16
1856 Sharp waves, bursts, and coherence: Activity in a songbird vocal circuit is influenced by behavioral state
Lorenz, C.; Das, A.; Centeno, E. G. Z.; Yeganegi, H.; Duvoisin, R.; Ursu, R.; Retailleau, A.; Giret, N.; Leblois, A.; Hahnloser, R. H. R.; Ondracek, J. M.
10.1101/2024.09.03.610933 — neuroscience — Posted on 2025-06-16
1857 A canonical chloroplast unfolded protein response triggered by misfolded polypeptides
Cantoia, A.; Bertero, F.; Berrocal, R.; Ceccarelli, E. A.; Blanco, N. E.; Rosano, G. L.
10.1101/2025.06.11.659047 — plant biology — Posted on 2025-06-16
1858 Opposing effects of systemic and pancreas-specific inhibition of BCKDK on pancreatic carcinogenesis
Noji, M. C.; Demetriadou, C.; Landis, M.; Pennise, J.; Pinheiro, L. V.; Jaccard, A.; Chatoff, A.; Drummond, J.; Guo, K.; Azor, R.; Robertson, M. R.; Kawakami, R.; Marcinkiewicz, M. M.; Tobias, J. W.; Snyder, N. W.; Feldser, D.; Arany, Z.; Wellen, K. E.
10.1101/2025.06.10.658925 — cancer biology — Posted on 2025-06-16
1861 X-Atlas/Orion: Genome-wide Perturb-seq Datasets via a Scalable Fix-Cryopreserve Platform for Training Dose-Dependent Biological Foundation Models
Huang, A. C.; Hsieh, T.-H. S.; Zhu, J.; Michuda, J.; Teng, A.; Kim, S.; Rumsey, E. M.; Lam, S. K.; Anigbogu, I.; Wright, P.; Ameen, M.; You, K.; Graves, C. J.; Kim, H. J.; Litterman, A. J.; Sit, R. V.; Blocker, A.; Chu, C.
10.1101/2025.06.11.659105 — genomics — Posted on 2025-06-16
1864 Proteomic and metabolic profiling reveals APOE4-dependent shifts in whole brain, neuronal, and astrocytic mitochondrial function and glycolysis
Lysaker, C. R.; Johnson, C.; Csikos, V.; Franczak, E.; Benson, M.; Gilmore, C.; Birky, C.; Davis, X.; McCoin, C.; Smith, K.; Puchalska, P.; Crawford, P.; Slawson, C.; Thyfault, J.; Geiger, P.; Morris, J.; Wilkins, H. M.
10.1101/2025.06.15.659811 — neuroscience — Posted on 2025-06-16
1865 High-throughput single-cell CRISPRi screens stratify neurodevelopmental functions of schizophrenia-associated genes
Yildiz, U.; Claringbould, A.; Marttinen, M.; Campos-Fornes, V.; Lamprousi, M.; Saraswat, M.; Saver, M.; Bunina, D.; Dorrity, M.; Zaugg, J. B.; Noh, K.-M.
10.1101/2025.06.13.659629 — neuroscience — Posted on 2025-06-16
1866 Preictal high-connectivity states in epilepsy: Evidence of intracranial EEG, interplay with the seizure onset zone and network modeling
Medina Leandro, B. N.; Vila-Vidal, M.; Tost, A.; Khawaja, M.; Carreno, M.; Roldan, P.; Rumia, J.; Centeno, M.; Conde, E.; Donaire, A.; Tauste, A.
10.1101/2025.01.24.634461 — neuroscience — Posted on 2025-06-16
1871 HIV-1 Envelope glycoprotein modulates CXCR4 clustering and dynamics on the T cell membrane
Quijada-Freire, A.; Santiago, C.; Garcia-Cuesta, E. M.; Soler Palacios, B.; Ayala-Bueno, R.; Gardeta, S.; San Sebastian, E.; Armendariz-Burgoa, E.; Puertas, M. C.; Villares, R.; Garaigorta, U.; Gonzalez-Granado, L. I.; Rodriguez Frade, J. M.; Chojnacki, J.; Martinez-Picado, J.; Mellado, M.
10.1101/2025.06.11.659074 — immunology — Posted on 2025-06-16
1872 Divergent effects of a Treg selective IL-2 mutein on Influenza-specific T cell responses
Albe, J. R.; Chaudhary, A.; Khanna, A.; Weinstein, K. N.; Ziegler, S. F.; Kalia, V.; Sarkar, S.; Campbell, D. J.
10.1101/2025.06.10.658962 — immunology — Posted on 2025-06-16
1881 Ataxin-2 preserves oocyte genome integrity by promoting timely premeiotic DNA replication
Monteiro, V. L.; Yu, C.; Camilla Roselli, C.; Baskar Bakthavachalu, B.; Mani Ramaswami, M.; Hurd, T. R.
10.1101/2025.06.13.659559 — genetics — Posted on 2025-06-16
1884 Causes and consequences of experimental variation in Nicotiana benthamiana transient expression
Tang, S. N.; Szarzanowicz, M.; Lanctot, A.; Sirirungruang, S.; Kirkpatrick, L. D.; Drako, K.; Alamos, S.; Cheng, A.; Waldburger, L. M.; Liu, S.; Thompson, M.; Shih, P.
10.1101/2025.06.12.659391 — plant biology — Posted on 2025-06-16
1887 Major effect mutations drive DNA methylation variation after colonization of a novel habitat
Zicola, J.; Tergemina, E.; Goktay, M.; Neto, C.; Schmitz, R. J.; Hancock, A. M.
10.1101/2025.06.14.659694 — genetics — Posted on 2025-06-16
1897 Environment-dependent selection impacts heritable developmental stability and trait canalization in rice
Dunivant, T. S.; Calic, I.; Gilligan, C.; Joly-Lopez, Z.; Choi, J. Y.; Natividad, M.; Cabral, C. L.; Torres, R. O.; Vergara, G. V.; Franks, S. J.; Henry, A.; Purugganan, M. D.; Groen, S. C.
10.1101/2025.06.13.659410 — evolutionary biology — Posted on 2025-06-16
1898 Beyond biomass: how interactions shape species' importance for ecosystem functioning
Ardichvili, A. N.; Loreau, M.; Onimus, T.; Galiana, N.; Lajaaiti, I.; Kefi, S.; Arnoldi, J.-F.
10.1101/2025.06.11.659013 — ecology — Posted on 2025-06-16
1902 A collection of patient-derived intestinal organoid lines reveals epithelial phenotypes associated with genetic drivers of pediatric inflammatory bowel disease
Jeshvaghani, Z. S.; Argmann, C.; Mokry, M.; van Es, J.; de Vries, M.; Collen, L.; Kotlarz, D.; Sveen, M.; Comella, P.; Snapper, S.; Klein, C.; Schadt, E.; Clevers, H.; Kuijk, E.; Nieuwenhuis, E.
10.1101/2025.06.11.659052 — genetics — Posted on 2025-06-16
1903 Distinct heterozygous TTC7A missense variants lead to different intestinal epithelial phenotypes in pediatric IBD
Jeshvaghani, Z. S.; Deenichina, P.; Collen, L.; de Vries, M.; Brunsveld, J.; Kotlarz, D.; Koletzko, S.; Klein, C.; Beekman, J.; Snapper, S.; Lindemans, C.; Mokry, M.; Argmann, C.; Kuijk, E.; Nieuwenhuis, E.
10.1101/2025.06.11.659065 — genetics — Posted on 2025-06-16
1906 Digital PCR detection of Mycobacterium tuberculosis and HIV-1 co-localization in spinal tuberculosis biopsies
Waters, R.; Martineau, A.; Laubscher, M.; Dunn, R. N.; Held, M.; Abrahams, M.-R.; Coussens, A. K.
10.1101/2025.06.11.659223 — microbiology — Posted on 2025-06-16
1908 Cryo-EM Structure of Photosystem I from mangroves in their natural environment
Malavath, T.; Heilmann, E.; Charras, Q.; Yuan, X.; Al-Amoudi, A.; Naschberger, A.; Gholami, A.
10.1101/2025.06.10.658896 — plant biology — Posted on 2025-06-16
1911 A Multimodal Adaptive Optical Microscope For In Vivo Imaging from Molecules to Organisms
Fu, T.-M.; Liu, G.; Milkie, D. E.; Ruan, X.; Gorlitz, F.; Shi, Y.; Ferro, V.; Divekar, N. S.; Wang, W.; York, H. M.; Kilic, V.; Mueller, M.; Liang, Y.; Daugird, T. A.; Gacha-Garay, M. J.; Larkin, K. A.; Adikes, R. C.; Harrison, N.; Shirazinejad, C.; Williams, S.; Nourse, J. L.; Sheu, S.-H.; Gao, L.; Li, T.; Mondal, C.; Achour, K.; Hercule, W.; Stabley, D.; Emmerich, K.; Dong, P.; Drubin, D.; Liu, Z. J.; Clapham, D.; Mumm, J. S.; Koyama, M.; Killilea, A.; Bravo-Cordero, J. J.; Keene, C. D.; Luo, L.; Kirchhausen, T.; Pathak, M. M.; Arumugam, S.; Nunez, J. K.; Gao, R. G.; Matus, D. Q.; Martin, B.
10.1101/2025.06.02.657494 — cell biology — Posted on 2025-06-16
1912 Subcellular reorganization upon phage infection reveals stepwise assembly of viral particles from membrane-associated precursors
Corroyer-Dulmont, S.; Labarde, A.; Prazak, V.; Godinho, L.; Masson, C.; Legrand, P.; Gruenewald, K.; Tavares, P.; Quemin, E.
10.1101/2025.06.15.659807 — cell biology — Posted on 2025-06-16
1918 AI-Guided CAR Design and AKT3 Degradation Synergize to Enhance Bispecific and Trispecific CAR-T Cell Persistence and Overcome Antigen Escape
Ansari, M. S.; Chauhan, V.; Singh, A.; Akhtar, A.; Chaudhary, N.; Tyagi, R.; Divya, ; Husain, K.; Sharma, S.; Alam, R.; Md Shakir, ; Pracha, M.; Anjum, S.; Mohd Nadeem, ; Faizan, M. I.; Azmi, I.; Iyer, A. R.; Gupta, P.; Nafiz, M.; Ali, S.; Ud din, I. M.; Javid, M.; Kuma P, H.; Srivastava, A. K.; Mabalirajan, U.; Mathews, V.; Ramalingam, S.; Kharya, G.; Ahmad, T.
10.1101/2025.06.12.658477 — cancer biology — Posted on 2025-06-15
1920 DeepFace: A High-Precision and Scalable Deep Learning Pipeline for Predicting Large-Scale Brain Activity from Facial Dynamics in Mice
Ozdemirli, K.; Connor, T.; Lacin, M. E.; Kim, K.; Maldonado, M.; Peixoto, T. L.; oksuz, c.; mata, i.; Yildirim, M.
10.1101/2025.06.10.658952 — neuroscience — Posted on 2025-06-15
1922 Depth-Resolved Macroscopic Fluorescence Lifetime Imaging via High-Spatial-Frequency Structured Illumination
Yuan, N.; Ragab, S.; Nizam, N. I.; Pandey, V.; Verma, A.; Young, T.; Williams, J. C.; Barroso, M.; Intes, X.
10.1101/2025.06.10.658928 — bioengineering — Posted on 2025-06-15
1930 Innervation of Retrodiscal Tissues in Patients with Temporomandibular Joint Disorder
Alfaro, J. J.; Hovhannisyan, A. H.; Locke, E. E.; Amarista, F. J.; Perez, D. E.; Akopian, A. N.
10.1101/2025.06.11.659119 — neuroscience — Posted on 2025-06-15
1931 Preventing Microglial Reactivity Protects from Acute and Progressive Neuronal Dysfunction, Motor Impairments and Sedation following Alcohol Abuse
Paouri, E.; Stanko, S.; Gasmi, N.; Glusauskas, G.; Mao, V.; Kwak, A.; Sarmadi, S.; Huang, E.; Hershberger, C.; Watercutter, Q.; Burton, H.; Crockett, A.; Gjojdeshi, A.; McMullen, M. R.; Hanamsagar, R. M.; Rotroff, D. M.; Prayson, R. A.; Bilbo, S. D.; Valadkhan, S.; Dana, H.; Nagy, L. E.; Davalos, D.
10.1101/2025.06.12.658437 — neuroscience — Posted on 2025-06-15
1933 Proximity labelling reveals the compartmental proteome of murine sensory neurons
Sondermann, J. R.; Barry, A. M.; Xian, F.; Haberl, T.; Gomez-Varela, D.; Benseler, F.; Schreiner, D.; Lipstein, N.; Brose, N.; Schmidt, M.
10.1101/2025.06.13.659475 — neuroscience — Posted on 2025-06-15
1935 Label-free structural imaging of plant roots and microbes using third-harmonic generation microscopy
Pan, D.; Rivera, J. A.; Miao, M.; Kim, P.; Tyml, T.; Rodriguez, C.; Afifa, U.; Wang, B.; Yoshikuni, Y.; Elisabeth, N. H.; Northen, T.; Vogel, J. P.; Ji, N.
10.1101/2024.04.13.589377 — plant biology — Posted on 2025-06-15
1936 Hepatic ADMA/PRMT1 axis regulation is associated with NO-dependent endothelial dysfunction in MASH
Lallement, J.; Bott, S.; Esfahani, H.; Serafimov, K.; Henderson, M.; Benoit, Z.; Dumas, L.; Al-Siyabi, S.; Feron, O.; Leclercq, I. A.; Dessy, C.
10.1101/2025.06.10.658894 — physiology — Posted on 2025-06-15
1939 Bringing the Genetically Minimal Cell to Life on a Computer in 4D
Thornburg, Z. R.; Maytin, A.; Kwon, J.; Brier, T. A.; Gilbert, B. R.; Fu, E.; Gao, Y.-L.; Quenneville, J.; Wu, T.; Li, H.; Long, T.; Pezeshkian, W.; Sun, L.; Glass, J.; Mehta, A.; Ha, T.; Luthey-Schulten, Z.
10.1101/2025.06.10.658899 — biophysics — Posted on 2025-06-15
1942 TRPV4 Inhibition Reduces Cartilage Growth During Axolotl Limb Regeneration
Kondiboyina, V.; Miller, M.; Ritterbuck, M.; Owen, A.; Duerr, T. J.; Monaghan, J. R.; Shefelbine, S. J.
10.1101/2025.06.10.658903 — bioengineering — Posted on 2025-06-15
1943 Bipartite chromatin recognition by Hop1 from two diverged holozoa
Rodriguez, A. A.; Cirulli, A. E.; Chau, K.; Nguyen, J.; Ye, Q.; Corbett, K. D.
10.1101/2025.06.14.659699 — biochemistry — Posted on 2025-06-15
1944 A high-affinity split-HaloTag for live-cell protein labeling
Lin, Y.-H.; Kompa, J.; Sun, D.-e.; Mao, R.; Koch, B.; Hinnah, K.; Wilhelm, J.; Franz, N.; Kühn, S.; Menche, T.; Adow, A.; Breuer, P.; Hiblot, J.; Johnsson, K.
10.1101/2025.06.15.659771 — biochemistry — Posted on 2025-06-15
1946 Systematic characterization of the ovarian landscape across mouse menopause models
Kim, M.; Bhala, R.; Wang, J.; Lu, R. J.; Lee, E. H.; Alvarenga, J. L.; Williams, R. G.; Benayoun, B. A.
10.1101/2025.06.10.658920 — genomics — Posted on 2025-06-15
1947 A collection of patient-derived intestinal organoid lines reveals epithelial phenotypes associated with genetic drivers of pediatric inflammatory bowel disease
Jeshvaghani, Z. S.; Argmann, C.; Mokry, M.; van Es, J.; de Vries, M.; Collen, L.; Kotlarz, D.; Sveen, M.; Comella, P.; Snapper, S.; Klein, C.; Schadt, E.; Clevers, H.; Kuijk, E.; Nieuwenhuis, E.
10.1101/2025.06.11.659052 — genetics — Posted on 2025-06-15
1948 Urbanization drives genetic and plastic responses of the spotted jewelweed flower morphology
Burkiewicz, J.; Carvalho, J.; Caporgno, S.; Lafond, J.; Devaux, C.; Normandin, E.; Joly, S.
10.1101/2025.06.10.658901 — evolutionary biology — Posted on 2025-06-15
1949 Spatial and temporal patterns of colony density and habitat associations of a small desert ant
Cao, A. L.; Milesi, F. A.; Pol, R. G.; Vullo, L.; Miretti, M. F.; Pirk, G. I.; Lopez de Casenave, J.
10.1101/2025.06.10.658907 — ecology — Posted on 2025-06-15
1950 Plasma membrane rather than endosomal Gq signaling drives transcriptional activity by the viral chemokine receptor US28 in glioblastoma
Daly, C.; Wright, A.; Heukers, R.; McKee, C. M.; Coll, R. C.; Evergren, E.; Smit, M. J.; Thomsen, A.; Plouffe, B.
10.1101/2025.06.12.659276 — cell biology — Posted on 2025-06-15
1953 High-resolution spatial mapping of cell state and lineage dynamics in vivo with PEtracer
Koblan, L. W.; Yost, K. E.; Zheng, P.; Colgan, W. N.; Jones, M. G.; Yang, D.; Kumar, A.; Sandhu, J.; Schnell, A.; Sun, D.; Ergen, C.; Saunders, R. A.; Zhuang, X.; Allen, W. E.; Yosef, N.; Weissman, J. S.
10.1101/2025.06.15.659774 — molecular biology — Posted on 2025-06-15
1954 Activin receptor type IIA/B blockade increases muscle mass and strength, but compromises glycemic control in mice
Carlsson, M.; Larsen, E. H. F.; Marmol, J. M.; Ali, M. S.; Raun, S. H.; Battey, E.; Andersen, N. R.; Irazoki, A.; lund, C.; Henriquez-Olguin, C.; Hoejfeldt, M. H.; Blomquist, P.; Bromer, F. D.; Lodberg, A.; Andersen, C. B. F.; Eijken, M.; Knudsen, J. R.; Richter, E. A.; Sylow, L.
10.1101/2025.06.11.659035 — molecular biology — Posted on 2025-06-15
1956 Ovarian Cancer Drives TLR5-Dependent Expansion of Myeloid Progenitors Through Systemic Dissemination of Ligands
Kolli, S. H.; McGinty, M. T.; Putelo, A. M.; Hatzinger, C. N.; Bajgai, S.; Poblete, M. K.; Thompson, B.; Feng, T.-Y.; Azar, F. N.; Mirani, A.; Petri, W.; Burgess, S. L.; Rutkowski, M. R.
10.1101/2025.06.10.658497 — immunology — Posted on 2025-06-15
1960 Canagliflozin reprograms the aging hippocampus in genetically diverse UM-HET3 mice and attenuates Alzheimer's-like pathology
Jayarathne, H. S.; Manchanayake, D. H.; Chimienti, N.; Kadri, O.; Gurdziel, K.; Kim, S.; Jang, H.; Ginsburg, B. C.; Miller, R. A.; Yakar, S.; Sadagurski, M.
10.1101/2025.06.10.658747 — neuroscience — Posted on 2025-06-15
1962 Two Specialized Intrinsic Cardiac Neuron Types Safeguard Heart Homeostasis and Stress Resilience
Xu, Q. J.; Applegate, M. C.; Hsu, I.-U.; Kogan, R. P.; Hafez, O. A.; Wang, R. L.; Rios Coronado, P. E.; Young, L. H.; Zeng, X.; Zhang, L.; Chang, R.
10.1101/2025.06.13.659555 — neuroscience — Posted on 2025-06-15
1963 Increased Synapse Elimination by Inflammatory Cells Contributes to Long-lasting Post-Stroke Memory Dysfunction in Old Mice
Shabani, Z.; Pan, P.; Li, Q.; Wang, Z.; Leng, K.; Sangras, S.; Huo, K.; Yadav, A.; Wang, C.; Shi, J.; Chinn, G.; Kyritsis, N.; Ferguson, A. R.; Hellman, J.; Su, H.
10.1101/2025.06.13.659591 — neuroscience — Posted on 2025-06-15
1964 The vagus nerve promotes memory via septo-hippocampal acetylcholine: Implications for obesity-induced cognitive dysfunction
Tierno Lauer, L.; Decarie-Spain, L.; Hayes, A. M. R.; Suarez, A. N.; Bashaw, A. G.; Klug, M. E.; Kao, A. E.; Cheng, R.; Rea, J. J.; Subramanian, K. S.; Nourbash, A. C.; Donohue, K. N.; Schier, L. A.; Myers, K. P.; Kanoski, S. E.
10.1101/2025.06.11.659206 — neuroscience — Posted on 2025-06-15
1965 Sex-dependent effects of maternal high-fat diet during lactation in adult THY-Tau22 mice offspring
Gauvrit, T.; Benderradji, H.; Pelletier, A.; Carvalho, K.; Aboulouard, S.; Faivre, E.; Chatelain, E.; Cannafarina, H.; Labous, L.; Launay, A.; Fourcot, M.; Kwiatkowski, D.; Chesnais, L.; Vallez, E.; Cardon, T.; Deleau, A.; Thiroux, B.; Eddarkaoui, S.; Bogdanova, A.; Besegher, M.; Delahaye, F.; Annicotte, J.-S.; Le Gras, S.; Tailleux, A.; Salzet, M.; Marot, G.; Buee, L.; Blum, D.; Vieau, D.
10.1101/2025.06.10.658847 — neuroscience — Posted on 2025-06-15
1966 Generation of knock-in Cre and FlpO mouse lines for precise targeting of striatal projection neurons and dopaminergic neurons
Albarran, E.; Fushiki, A.; Nelson, A.; Ng, D.; Chaimowitz, C.; Nikoobakht, L.; Sippy, T.; Peterka, D. S.; Costa, R. M.
10.1101/2025.06.15.659794 — neuroscience — Posted on 2025-06-15
1969 Supervised white matter bundle segmentation in glioma patients with transfer learning
Riccardi, C.; Coletta, L.; Ghezzi, S.; Amorosino, G.; Zigiotto, L.; Jovicich, J.; Sarubbo, S.; Avesani, P.
10.1101/2025.06.13.659452 — neuroscience — Posted on 2025-06-15
1970 Post-translational modifications distinguish amyloid-β isoform patterns extracted from vascular deposits and parenchymal plaques
Koutarapu, S.; Roberts, K. F.; Coyle, R. A.; Mehla, J.; Sato, C.; Zipfel, G. J.; Bateman, R. J.; Schwetye, K. E.; Mukherjee, S.
10.1101/2025.06.11.658821 — neuroscience — Posted on 2025-06-15
1972 Astrocytes control motor neuronal mitochondrial axonal transport deficits in C9ORF72 ALS.
Stavrou, M.; Heffernan, A.; Carter, R. N.; Dando, O.; Jiwaji, Z.; Burr, K.; Nanda, J.; Cholewa, J.; Story, D.; Hardingham, G.; Selvaraj, B.; Chandran, S.
10.1101/2025.06.10.658820 — neuroscience — Posted on 2025-06-15
1973 Problem-solving without a cortex: inferior lobe drives goal-directed object manipulation in cichlid fish
Estienne, P.; Page, G.; Poon, G.; Larrat, B.; Durier, T.; Dufresne, A.; Ciobanu, L.; Yamamoto, K.
10.1101/2025.06.10.658878 — neuroscience — Posted on 2025-06-15
1974 Challenges in Replay Detection by TDLM in Post-Encoding Resting State
Kern, S.; Nagel, J.; Wittkuhn, L.; Gais, S.; Dolan, R. J.; Feld, G. B.
10.1101/2025.06.11.658835 — neuroscience — Posted on 2025-06-15
1976 Mapping of individual somatosensory representations - comparison of fMRI and TMS
Gogulski, J. D.; Nyrhinen, M.; Zetter, R.; Tokariev, M.; Lin, H.; Pertovaara, A.; Carlson, S.
10.1101/2025.06.12.659279 — neuroscience — Posted on 2025-06-15
1978 Modulation of SLP-2 expression protects against alpha-synuclein neuropathology by mitigating mitochondrial dysfunction
Bolduc, C.; Castelo Rueda, M. P.; Lorente Picon, M.; Gentile, G.; Kalvakuri, S.; Soto Linan, V.; Zanon, A.; Laouafa, S.; Lang, M.; Lavdas, A. A.; Gilmozzi, V.; Bernardo, G.; Coulombe, V.; Gora, C.; Peralta, M.; Rioux, V.; Honisch, C.; Pramstaller, P. P.; Ruzza, P.; Ziviani, E.; Bodmer, R.; Hicks, A. A.; Parent, M.; Soliz, J.; Joseph, V.; Pichler, I.; Levesque, M.
10.1101/2025.06.13.659577 — neuroscience — Posted on 2025-06-15
1979 An intracortical brain-machine interface based on macaque ventral premotor activity
De Schrijver, S.; Ramirez, J. G.; Iregui, S.; Aertbelien, E.; De Schutter, J.; Theys, T.; Decramer, T.; Janssen, P.
10.1101/2025.06.11.659174 — neuroscience — Posted on 2025-06-15
1982 A systemic clock brake: Period1 stabilizes the circadian network under environmental stress
Kim, P.; Kumar, V.; Garner, N.; Jayasinghe, O.; Roman, G.; Walters, S.; Vo, T. Q. A.; Nguyen, Q.; Bowles, J.; Woodruff, T. M.; Inder, W.; Hunt, J.; Heyde, I.; Oster, H.; Rawashdeh, O.
10.1101/2025.06.12.659230 — neuroscience — Posted on 2025-06-15
1983 RubyACRs Enable Red-Shifted Optogenetic Inhibition in Freely Behaving Drosophila
Bushey, D.; Shiozaki, H. M.; Shuai, Y.; Zheng, J.; Jayaraman, V.; Kolb, I.; Hasseman, J. P.; GENIE Project Team, ; Turner, G. C.
10.1101/2025.06.13.659144 — neuroscience — Posted on 2025-06-15
1986 Cryo-EM Structure of Photosystem I from mangroves in their natural environment
Malavath, T.; Heilmann, E.; Charras, Q.; Yuan, X.; Al-Amoudi, A.; Naschberger, A.; Gholami, A.
10.1101/2025.06.10.658896 — plant biology — Posted on 2025-06-15
1987 Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging
De Man, R.; Cai, Z.; Doddaballapur, P.; Guerrera, N.; Lin, L.; Justet, A.; Abu Hussein, N. S.; Cavinato, C.; Raredon, M. S. B.; Heerdt, P.; Singh, I.; Yan, X.; Kang, M.-J.; Bruns, D. R.; Lee, P. J.; Tellides, G.; Humphrey, J.; Kaminski, N.; Ramachandra, A. B.; Manning, E. P.
10.1101/2025.06.10.658632 — physiology — Posted on 2025-06-15
1988 Reversible Antagonism of Dopamine D1 Receptor using a Photoswitchable Remotely Tethered Ligand
Hetzler, B. E.; Donthamsetti, P. C.; Wolesensky, R. M.; Stanley, C.; Isacoff, E.; Trauner, D.
10.1101/2025.06.10.658926 — pharmacology and toxicology — Posted on 2025-06-15
1990 Constrained template matching using rejection sampling
Maurer, V. J.; Grunwald, L.; Kennes, D. M.; Kosinski, J.
10.1101/2025.06.10.658890 — biophysics — Posted on 2025-06-15
1991 Encapsulation-enhanced genetic switches in lactobacilli
Blanch-Asensio, M.; Tadimarri, V. S.; Martinez, R. P.; Dahiya, G. S.; Duong, C. N.; Lale, R.; Sankaran, S.
10.1101/2025.01.10.632477 — bioengineering — Posted on 2025-06-15
1993 Desert Hedgehog mediates stem Leydig cell differentiation through Ptch2/Gli1/Sf1 signaling axis
Zhao, C.; Chen, Y.; Liu, L.; Liu, X.; Xiao, H.; Wang, F.; Huang, Q.; Dai, X.; Tao, W.; Wang, D.; Wei, J.
10.1101/2025.06.13.659479 — developmental biology — Posted on 2025-06-15
1995 The Staphylococcus aureus prophage-encoded SSBP attenuates virulence and enhances IL-6-mediated macrophage clearance
Ahmad-Mansour, N.; Abi Najem, C. N.; Martin, M.; Plumet, L.; Huc-Brandt, S.; Morsli, M.; Francois, P.; Sotto, A.; Dunyach-Remy, C.; Lavigne, J.-P.; MOLLE, V.
10.1101/2025.03.13.643069 — microbiology — Posted on 2025-06-15
1996 An archaeal CBASS system eliminates viruses without killing the host cells
Choudhary, D. K.; Singla, H.; Vassover, D.; Golan, N.; Reshef, L.; Shukrun, H.; Gophna, U.
10.1101/2024.09.12.612678 — microbiology — Posted on 2025-06-15
1997 The capsule and genetic background, rather than specific individual loci, strongly influence in vitro pneumococcal growth kinetics
Chaguza, C.; Arends, D. W.; Lo, S. W.; Putri, I. H.; York, A.; Lees, J. A.; Wyllie, A. L.; Weinberger, D. M.; Bentley, S. D.; de Jonge, M. I.; Cremers, A. J. H.
10.1101/2024.12.05.627025 — microbiology — Posted on 2025-06-15
1998 Multiplexed Neuromodulatory-Type-Annotated EM-Reconstruction of Larval Zebrafish
Li, F.-n.; Liu, J.-z.; Shi, C.; Yuan, J.-b.; Lv, Y.-n.; Liu, J.; Zhang, L.-n.; Li, L.-l.; Shen, L.-j.; Chen, X.; Zhai, H.; Chen, B.-h.; Zhang, Y.-c.; Chen, H.-r.; Yan, H.-y.; Chang, S.; Ma, H.-t.; Zhou, F.-x.; Xin, T.; Dong, X.-h.; Lin, L.-m.; Zhao, X.-h.; Fang, Z.-h.; Zu, J.-l.; Tao, R.-k.; Hu, H.-y.; Qian, C.-y.; Wang, Y.-s.; Zhang, C.-m.; Xiang, P.-s.; Yang, Y.-x.; Du, X.-f.; Han, H.; Du, J.-l.
10.1101/2025.06.12.659365 — neuroscience — Posted on 2025-06-15
2000 Long-term Nrf2-driven microglial repopulation mitigates microgliosis, neuronal loss and cognitive deficits in tauopathy
Viqueira, L.; Navarro, E.; Negredo, P.; Bernal, J. A.; Rodriguez-Franco, M. I.; Tortosa, E.; Lopez, M. G.
10.1101/2025.06.11.659019 — neuroscience — Posted on 2025-06-15
2001 Viral Infection Induces Alzheimer's Disease-Related Pathways and Senescence in iPSC-Derived Neuronal Models
Hribkova, H.; Pospisilova, V.; Amruz Cerna, K.; Vanova, T.; Haviernik, J.; Sedmik, J.; Bernatik, O.; Olha, J.; Raska, J.; Ruzek, D.; Sheardova, K.; Vajrychova, M.; Gresova, K.; Cesnarikova, S.; Satkova, M.; Plesingrova, K.; Maragkakis, M.; Strakova, P.; Fortova, A.; Sadibolova, M.; Kupcik, R.; Fabrik, I.; Bohaciakova, D.
10.1101/2025.06.11.659008 — neuroscience — Posted on 2025-06-15
2005 Overnight circuit remodelling drives juvenile alloparental care
Jamieson, B. B.; Chen, M. X.; Liang, S.; El Rasheed, L. S. H.; Chattey, G. M. K.; Kohl, J.
10.1101/2025.06.13.659524 — neuroscience — Posted on 2025-06-15
2006 FiPhoPHA - A fiber photometry python package for post-hoc analysis
Drakopoulos, V.; Reichenbach, A.; Stark, R.; Foldi, C. J.; Jean-Richard-dit-Bressel, P.; Andrews, Z. B.
10.1101/2025.06.12.659422 — neuroscience — Posted on 2025-06-15
2007 Aβ-HMGB1 complex is a pathogenic molecule at the advanced stage of Alzheimer's disease
Tanaka, H.; Homma, H.; Yoshioka, Y.; Fujita, K.; Yamada, S.; Furukawa, K.; Ishiki, A.; Atsuta, N.; Waragai, M.; Mano, T.; Katsuno, M.; Sobue, G.; Arai, H.; Iwata, A.; Okazawa, H.
10.1101/2025.06.12.659430 — neuroscience — Posted on 2025-06-15
2008 Selective-plane Functional Ultrasound Neuroimaging
Waasdorp, R.; Gouwerok, T.; Munoz-Ibarra, E.; Nelissen, F.; Gazzola, V.; Renaud, G. G. J.; Maresca, D.; Heiles, B.
10.1101/2025.06.12.659275 — neuroscience — Posted on 2025-06-15
2009 Sleep strengthens successor representations of learned sequences
He, X.; Büchel, P. K.; Faghel-Soubeyrand, S.; Klingspohr, J.; Kehl, M. S.; Staresina, B. P.
10.1101/2025.06.11.658893 — neuroscience — Posted on 2025-06-15
2010 Response dynamics of discrete subiculum->retrosplenial cortex projections underlying trace fear conditioning
Bassett, T. E.; Wang, Y.-Z.; Wood, E. M.; Zhang, H.; Petrovic, Z.; Prifti, V.; Jovasevic, V.; Yamawaki, N.; Ren, L.; Khalatyan, N.; Grayson, V.; Savas, J. N.; Radulovic, J.; Cicvaric, A.
10.1101/2025.06.12.659393 — neuroscience — Posted on 2025-06-15
2011 Characterization of neuronal ensembles in a model of dual reward conditioned place preference
Flom, L. T.; Sandum, K.; Hodgins, S.; Johnson-Noya, S.; Crouse, J.; Zhang, Z.; Bobadilla, A. C.
10.1101/2025.06.11.659163 — neuroscience — Posted on 2025-06-15
2013 Induction of Human Pruriceptors from Pluripotent Stem Cells via Transcription Factors
Iriki, H.; Hu, R.; Li, X.; Baljinnyam, E.; Habich, C.; Imanishi, I.; Miller, L.; Chegireddy, K.; Malik, L. I.; Yassky, D.; Heul, A. V.; Smith, K. M.; Goedken, E. R.; Reinhardt, P.; Kim, B. S.; Marro, S. G.
10.1101/2025.06.11.659208 — neuroscience — Posted on 2025-06-15
2015 GPR68, a proton-sensing GPCR, mediates acid-induced visceral nociception
Paine, L. W.; Gupta, R.; Higham, J.; Aguilera-Lizarraga, J.; Ritoux, A.; Pritchard, T.; Nicholson, S.; Hockley, J.; Raine, T.; Hausmann, M.; Bednar, K.; Rogler, G.; Welsh, F.; Smith, E. S. J.; Bulmer, D.
10.1101/2025.06.13.659465 — neuroscience — Posted on 2025-06-15
2017 Arousal-Driven Serial Dependence: Internal States Modulate Perceived Duration
Cheng, S.; Jin, W.; Shan, X.; Kara, E. B.; Bilgic, S. E.; Salomasova, S.; Unterguggenberger, Q.; Shi, Z.
10.1101/2025.06.15.659791 — neuroscience — Posted on 2025-06-15
2018 DCPS modulates TDP-43 mediated neurodegeneration through P-body regulation
Ye, Y.; Zhang, Z.; Yu, X.; Zhu, C.; Wright, N.; Asbury, J.; Huang, Y.; Wang, W.; Gomez-Isaza, L.; Troncoso, J.; He, C.; Sun, S.
10.1101/2025.06.13.659508 — neuroscience — Posted on 2025-06-15
2019 Drosophila Modeling of Insomnia-Associated Genes Reveals Diverse Underlying Sleep Phenotypes
Mandigo, T. R.; Abou Daya, F.; Math, S.; Ye, A. Q.; Maher, M.; Saxena, R.; Walker, J. A.
10.1101/2025.06.12.659376 — neuroscience — Posted on 2025-06-15
2020 Shared Neural Signatures of Socioeconomic Status, Scarcity, and Neighborhood Threat in Youth
Brosch, K.; Wiersch, L.; Christensen, E.; Rakesh, D.; Hanson, J.; Schwartz, R. M.; Dhamala, E.
10.1101/2025.06.11.659188 — neuroscience — Posted on 2025-06-15
2022 iSleep: Continuous, binocular pupil tracking in sleep and reduced consciousness for physiological monitoring, predictions and interventions
Yuzgec, O.; Legendre, G.; Asadian, A.; Gloria, Y.; Bayer, L.; Tourdot, Q.; Pellat, S.; Novozhilova, S.; D'Ancona, C.; Ulanova, M.; Kecik, M.; Maccari, A.; Lopez, D.; Licini, L.; Nguyen Tang, G.; Van Delden, S.; Bravetti, G. E.; Vo, T.; Kropp, M.; Boex, C.; Jakus, L.; Schaller, K.; Sollander, F.; Vutskits, L.; Thumann, G.; Schwartz, S.; Huber, D.
10.1101/2025.06.13.659058 — neuroscience — Posted on 2025-06-15
2023 Intrinsically disordered regions facilitate Msn2 target search to drive promoter selectivity
Strugo, N.; Burstein, C.; Hossain, S. S.; Nago, N.; Goldsmith, M.; Khamis, H.; Kaplan, A.
10.1101/2025.05.23.654710 — biophysics — Posted on 2025-06-15
2024 Investigating diurnal effects and joint nest defense behavior in Herring Gulls
Shah, S. S.; Ellms, M. E.; Dygean, F.; Gunasekera, S.; Hart, E.; Ivanyi, R. E.; Lane, M.; Liu, D.; Pitcher, D.; Saucier, A.; Schroeder, K. F.; Triquet, J.; Williams, K.; Covino, K. M.
10.1101/2025.06.13.659635 — animal behavior and cognition — Posted on 2025-06-15
2028 Single-cell omics reveal distinct gene regulatory dynamics underpinning embryonic and extraembryonic lineage functions during pig blastocyst development
Dufour, A.; Rossignol, M.-N.; Manceau, P.; Bailly, Y.; Ferchaud, S.; Mercat, M.-J.; Turhan, A. G.; Djebali, S.; Foissac, S.; Artus, J.; Acloque, H.
10.1101/2025.06.15.657618 — developmental biology — Posted on 2025-06-15
2029 Major waves of H2A.Z incorporation during mouse oogenesis
Fosslie, M.; Ilaslan, E.; Skuland, T.; Manaf, A.; Soegaard, M. L. C.; Indahl, M.; Vera-Rodriguez, M.; Suganthan, R.; Jermstad, I.; Khanam, S.; Dalen, K. T.; Eskeland, R.; Choudalakis, M.; Bjoras, M.; Fedorcsak, P. Z.; Greggains, G. D.; Zagrobelny, M.; Dahl, J. A.; Lerdrup, M.
10.1101/2025.06.14.659461 — developmental biology — Posted on 2025-06-15
2030 Quantitative Proteomics Links Mitochondrial Dysfunction to Metabolic Changes and Epithelial Differentiation Defects in Hyperoxia-Exposed Neonatal Airway Cells
Ganguly, A.; Carter, C. M.; Negron, A. R.; Zhong, H.; Moreira, A.; Walters, M. S.; Rogers, L. K.; Prakash, Y. S.; Tipple, T. E.; Richardson, A.
10.1101/2025.06.15.659571 — developmental biology — Posted on 2025-06-15
2031 Effects of Ambient Temperature During Pregnancy on Newborn Birthweight
Nargund, R.; Marchesoni, J.; Bareja, A.; W. Sosnowski, D.; Peng, G.; Hoyo, C.; Pan, W.; K. Murphy, S.
10.1101/2025.06.10.658978 — developmental biology — Posted on 2025-06-15
2035 Neurons, Muscles, and Venom: Identifying Drivers of Cephalopod Predation
Kirchhoff, K. N.; Williams, M.; Stambouli, B.; Pardo-Blas, J. R.; Courtney, A.; Sugarman, A. L.; Vanselow, D. J.; Carrasco, C.; Cuddy, C.; Schafer, W. R.; Cheng, K. C.; Seuntjens, E.; Holford, M.
10.1101/2025.06.15.659772 — neuroscience — Posted on 2025-06-15
2037 Cholesterol Inhibits HCN Channels through Dual Mechanisms in Neuropathic Pain
Handlin, L. J.; Giere, C.; Dumaire, N. L.; Salih, L.; Moutal, A.; Dai, G.
10.1101/2025.06.15.659789 — neuroscience — Posted on 2025-06-15
2039 Human placental stem cells induce a novel multiple myeloid cell-driven immunosuppressive program that ameliorates proinflammatory CNS pathology
Sarlus, H.; Guo, Y.; Bencina, S.; Zhu, K.; Joshua, V.; Virgilio, G. A.; Cheng, Y.; Lin, J.; Min, J. H.; Cuesta, I. B.; Suerth, V.; Alonso, P. T.; Thomas, O. G.; Rykaczewska, U.; Cacais, A. O. G.; Jagodic, M.; Gramignoli, R.; Harris, R. A.
10.1101/2025.06.14.659704 — neuroscience — Posted on 2025-06-15
2047 RpS12-mediated induction of the Xrp1short isoform links ribosomal protein mutations to cell competition
Potiri, M.; Tsakiri, E.; Kontogiannidi, K.; Loizou, M.; Skoulakis, E. M. C.; Samiotaki, M.; Kafasla, P.; Kiparaki, M.
10.1101/2025.06.15.659587 — developmental biology — Posted on 2025-06-15
2048 The nucleus forms a dynamic contact with the plasma membrane to maintain the glandular epithelial architecture
Rayer, M. S.; Mui, K.; Pendyala, K.; Rockenbach Zenzen, J. A.; Antoku, S.; Lele, T.; Gundersen, G. G.
10.1101/2025.06.13.659552 — cell biology — Posted on 2025-06-15
2049 Treatment with the ribosome biogenesis inhibitor CX-5461 increases platelet count in humans and enhances murine megakaryopoiesis
Bhoopalan, V.; Kaur, A.; Hearn, J. I.; Maclachlan, K. H.; Liu, L.; Ferreira, R.; Ali, S. A.; Thong, Y. L.; Hein, N.; Nazir, S.; Brysland, S. A.; Man, S. M.; Harrison, S. J.; Andrews, R. K.; Eto, K.; Choi, P. Y.-I.; Wen, J.; Hannan, K. M.; Hannan, R. D.; Gardiner, E. E.
10.1101/2025.06.15.659730 — cell biology — Posted on 2025-06-15
2050 Oviduct fluid metabolic regulation of embryonic genome methylation
Fuego, D. M.; Devkota, I.; Bonomo, Z. L.; Li, Y.; Zhang, X.; Dondeti, M. F.; Donnarumma, F.; Matsakas, A.; Patterson, A. L.; Williams, C. C.; Vourekas, A.; Fu, X.; Bondioli, K. R.; Simintiras, C. A.
10.1101/2025.06.13.659599 — cell biology — Posted on 2025-06-15
2051 Ciliary and non-ciliary functions of CEP104 in Xenopus
Louka, P.; Potamiti, L.; Panayiotidis, M. I.; Skourides, P.
10.1101/2025.06.12.659327 — cell biology — Posted on 2025-06-15
2052 Condensate-driven chromatin organization via elastocapillary interactions
Zhao, H.; Strom, A. R.; Eeftens, J. M.; Haataja, M.; Kosmrlj, A.; Brangwynne, C. P.
10.1101/2025.06.12.659369 — biophysics — Posted on 2025-06-15
2054 Mechanochemical feedback between confinement and actin crosslinking drives the shape dynamics of liquid-like droplets
Mansour, D.; Jordan, D.; Walker, C.; Chandrasekaran, A.; Lee, C. T.; Graham, K.; Stachowiak, J.; Rangamani, P.
10.1101/2025.06.13.659650 — biophysics — Posted on 2025-06-15
2056 Nutritional iron deficiency elicits profound rewiring of red pulp macrophage functions via high FPN and SYK-mediated signaling
Mandal, P. K.; Chouhan, K.; Slusarczyk, P.; Mahadeva, R.; Zurawska, G.; Niklewicz, M.; Jonczy, A.; Lenartowicz, M.; Pokrzywa, W.; Meynard, D.; Nemeth, E.; Mleczko-Sanecka, K.
10.1101/2025.06.13.659526 — cell biology — Posted on 2025-06-15
2059 Proof-of-Concept in a Murine Model of Treatment of Thrombotic Thrombocytopenic Purpura Using Engineered Red Blood Cells
Roberts, K. S.; Zhang, S.; Batbayar, K.; Yan, Z.; Muia, J.; Mulvey, J. J.; Olivier, E.; Pullman, J. M.; Cataland, S. R.; Bouhassira, E. E.
10.1101/2025.06.12.659386 — cell biology — Posted on 2025-06-15
2061 Functional rescue of a fatal ERAD mutation via alternative splicing
Wang, H.; Wang, Z.; Lin, L.; Verma, S.; Gniadzik, W.; Wang, H.; Li, Z.; Jiang, L.; Kuyumcu-Martinez, M.; Sun, S.; Qi, L.
10.1101/2025.06.13.659581 — cell biology — Posted on 2025-06-15
2062 The nucleus activates mechano-responsiveness via FHOD-associated LINC complexes
Antoku, S.; Gundersen, G. G.; Worman, H. J.; Morrow, J. P.; Joseph, L. C.; Fine, B. M.; Zhang, X.; Kushner, J.; Lin, C.-S.; Schwartz, T.; Dabhade, P.
10.1101/2025.06.13.659598 — cell biology — Posted on 2025-06-15
2063 Topologically-based parameter inference for agent-based model selection from spatiotemporal cellular data
Wenzel, A. R.; Haughey, P. M.; Nguyen, K. C.; Nardini, J. T.; Haugh, J. M.; Flores, K. B.
10.1101/2025.06.13.659586 — cell biology — Posted on 2025-06-15
2064 Occludin Acts as a Dynein Adaptor Regulating Permeability and Collateral Angiogenesis
Liu, X.; Su, E. J.; Dreffs, A.; Gillies, J. P.; Merlino, M.; Gao, L.; Peregoff, J. S.; Lin, C.-m.; Ross, M. E.; DeSantis, M. E.; Lawrence, D. A.; Antonetti, D. A.
10.1101/2025.06.12.659326 — cell biology — Posted on 2025-06-15
2065 PB-scope: Contrastive learning of dynamic processing body formation reveals undefined mechanisms of approved compounds
Shen, D.; Zhu, Q.; Pang, X.; Yang, X.; Pan, D.; Zhang, M.; Li, Y.; Sun, Z.; Fang, L.; Chen, W.; Tsuboi, T.
10.1101/2025.06.14.659731 — cell biology — Posted on 2025-06-15
2066 Native, Spatiotemporal Profiling of the Global Human Regulome
Pino, L. K.; Canzani, D.; Gutierrez, A.; Hubbard, E.; Broderick, E.; Prymolenna, A.; Mercenne, G.; Siebenthall, K.; Fondrie, W. E.; Robbins, J.; McEllin, B.; Takta, L.; Paez, J. S.; Federation, A. J.
10.1101/2025.06.14.659727 — cell biology — Posted on 2025-06-15
2067 The role of amygdala calcitonin gene-related peptide receptors on the development of persistent bladder pain in mice.
Lewter, L. A.; Paul, B. K.; Salazar, A. M.; Chatterjee, U. R.; Pham, H. P. T.; Khan, M. Z.; Schmitz, A. E.; Nofal, A. M.; Hussein, M. M.; Mysorekar, I. U.; Kolber, B. J.
10.1101/2025.06.10.658965 — neuroscience — Posted on 2025-06-15
2068 A connectomic resource for neural cataloguing and circuit dissection of the larval zebrafish brain
Petkova, M. D.; Januszewski, M.; Blakely, T.; Herrera, K. J.; Schuhknecht, G. F. P.; Tiller, R.; Choi, J.; Schalek, R. L.; Boulanger-Weil, J.; Peleg, A.; Wu, Y.; Wang, S.; Troidl, J.; Kumar Vohra, S.; Wei, D.; Lin, Z.; Bahl, A.; Tapia, J. C.; Iyer, N.; Miller, Z. T.; Hebert, K. B.; Pavarino, E. C.; Taylor, M.; Deng, Z.; Stingl, M.; Hockling, D.; Hebling, A.; Wang, R. C.; Zhang, L. L.; Dvorak, S.; Faik, Z.; King, K. I.; Goel, P.; Wagner-Carena, J.; Aley, D.; Chalyshkan, S.; Contreas, D.; Li, X.; Muthukumar, A. V.; Vernaglia, M. S.; Tapia Carrasco, T.; Melnychuck, S.; Yan, T.; Dalal, A.; DiMarti
10.1101/2025.06.10.658982 — neuroscience — Posted on 2025-06-15
2069 CTCF is crucial for decidualization of uterine stromal cells through facilitating HOXA11 expression
Yang, X.-Q.; Jiang, R.-F.; Zhang, A.-N.; Deng, Y.-M.; Tang, S.; Zhang, Q.-Y.; Xu, Y.-W.; Yang, S.-H.; Liu, J.-L.
10.1101/2025.06.10.658981 — physiology — Posted on 2025-06-15
2073 Scalable expansion and hepatic zone maturation of hepatic progenitor cells from human pluripotent stem cells
Ogawa, S.; Ogawa, M.; Liu, J. C.; Dadvar, A.; Tian, B.; Zhao, X.; Fernandes, I.; Minegishi, K.; Takase, K.; Higuchi, Y.; Suemizu, H.; McGilvray, I.; MacParland, S.; Bader, G.
10.1101/2025.06.13.659636 — cell biology — Posted on 2025-06-15
2074 Mitochondrial Dysfunction Drives Age-Related Degeneration of the Thoracic Aorta
Dhanekula, A. S.; Harrison, B.; Pharaoh, G.; Mattson-Hughes, A.; Tarantini, S.; Stuppard, R.; DeRoo, S.; Burke, C. R.; Hwang, B.; Pal, J. D.; Mulligan, M. S.; Marcinek, D.
10.1101/2025.06.13.659620 — cell biology — Posted on 2025-06-15
2076 A bipartite, mutation-tolerant NLS regulates interaction of ΔNp63α with importin alpha, nuclear transport and transcriptional activity
De Marinis, A.; Esmaeili, S.; Swarbrick, C. M. D.; Ranno, S.; Pavan, S.; Forwood, J. K.; McSharry, B. P.; Pal, M.; Di Iorio, E.; Alvisi, G.
10.1101/2025.06.12.659319 — cell biology — Posted on 2025-06-15
2078 Napping alters Functional Brain Responses in the Aged
Reyt, M.; Dourte, M.; DeHaan, S.; Deantoni, M.; Baillet, M.; Lesoinne, A.; Laloux, S.; Hammad, G.; Collette, F.; Peigneux, P.; Muto, V.; Vandewalle, G.; Bahri, M. A.; Phillips, C.; Schmidt, C.
10.1101/2025.06.10.657597 — neuroscience — Posted on 2025-06-15
2079 rAAV-miniBEND: A targeted vector for brain endothelial cell gene delivery and cerebrovascular malformation modeling
Li, J.-L.; Bi, Z.; Chen, X.-j.; Ming, T.; Qiu, B.; Li, F.; Feng, Z.; Ai, D.; Zhang, T.; Wang, J.; Lin, S.; Lu, Y.; Wang, Z.; Huang, J.; Zhao, F.; Zhao, H.; Wang, Y.; Sun, W.; Ge, W.-p.
10.1101/2025.06.10.658979 — neuroscience — Posted on 2025-06-15
2080 NanoBondy reacting through NeissLock anhydride allows covalent immune cell decoration
Vankayala, L. R.; Adoni, K. R.; Lim, S. Y.; Dushek, O.; Thalassinos, K.; Howarth, M. R.
10.1101/2025.06.14.659678 — synthetic biology — Posted on 2025-06-15
2081 EARLY RAINY SEASON PATTERNS OF FERN DIVERSITY AND ECOLOGICAL DISTRIBUTION IN AMURUM FOREST RESERVE, JOS PLATEAU.
Tumba, C. Y.; Samuel, G.; Ibrahim, I.; Abok, C. J.; Cleophas, A. B.; Chaskda, A. A.; Diffa, A. A.
10.1101/2025.06.10.659003 — plant biology — Posted on 2025-06-15
2087 Dissecting the biological impact of GBA1 mutations using multi-omics in an isogenic setting
Alvarez Jerez, P.; Wild Crea, P. A.; Patel, D.; Glasstetter, L. M.; Alvarez, C.; Makarious, M. B.; Lara, E.; Chen, Y.; Pantazis, C. B.; Paquette, K.; Malik, L.; Nalls, M. A.; Reed, X.; Singleton, A. B.; Billingsley, K. J.; Mcdonough, J. A.; Ning, G.; Skarnes, W. C.; Ryten, M.; Sidransky, E.; Cookson, M. R.; Beilina, S.; Blauwendraat, C.
10.1101/2025.06.12.656971 — genomics — Posted on 2025-06-15
2088 Organ-specific isolation of hepatocyte extracellular vesicles from human plasma enables tissue-resolved proteomic and miRNA profiling
Figueiras, R.; Vagueiro, S.; G.G Kay, R.; Persia, E.; de Alwis, R.; Hijazi, R.; Davidson, B.; Sanches-Kuiper, R.; Arsene, P.; Dias, T.
10.1101/2025.06.13.658908 — molecular biology — Posted on 2025-06-15
2090 PhysDock: A Physics-Guided All-Atom Diffusion Model for Protein-Ligand Complex Prediction
Zhang, K.; Ma, Y.; Yu, J.; Luo, H.; Lin, J.; Qin, Y.; Li, X.; Jiang, Q.; Bai, F.; Dou, J.; Zheng, J.; Yu, J.; Sun, L.
10.1101/2025.04.28.650887 — bioinformatics — Posted on 2025-06-15
2092 Structure of endogenous Pfs230:Pfs48/45 in complex with potent malaria transmission-blocking antibodies
Bekkering, E. T.; Yoo, R.; Hailemariam, S.; Heide, F.; Ivanochko, D.; Jackman, M.; Proellochs, N. I.; Stoter, R.; van Gemert, G.-J.; Maeda, A.; Yuguchi, T.; Wanders, O. T.; van Daalen, R. C.; Inklaar, M. R.; Andrade, C. M.; Jansen, P. W.; Vermeulen, M.; Bousema, T.; Takashima, E.; Rubinstein, J. L.; Kooij, T. W.; Jore, M. M.; Julien, J.-P.
10.1101/2025.02.14.638310 — molecular biology — Posted on 2025-06-15
2093 Early Postnatal Dysfunction of ACC PV Interneurons in Shank3B-/- Mice
Shih, Y.-C.; Nelson, L.; Janecek, M.; Matarazzo, M.; D'Agostino, A.; Peixoto, R. T.
10.1101/2024.10.04.616584 — neuroscience — Posted on 2025-06-15
2096 Larger larval sea lamprey (Petromyzon marinus) have longer survival times when exposed to the lampricide 3-trifluoromethyl-4-nitrophenol
Nalesnik, A. M.; Martin, E. L.; Kovacs, I. S.; Johnson, C. S.; Carroll, E. I.; Jubar, A.; Hemstrom, W.; Wilkie, M. P.; Dunlop, E. S.; Sepulveda, M. S.; Johnson, N. S.; Christie, M. R.
10.1101/2025.01.10.632359 — evolutionary biology — Posted on 2025-06-15
2097 Widespread loss of sleep in independently evolved populations of wild-caught cavefish
North, O.; Maza-Castaneda, L. C.; Manning, A. E.; Rastogi, A.; Gluesenkamp, A.; Gluesenkamp, L.; Swanson, N.; Hernandez-Lozano, J.; Garduno-Sanchez, M.; Diaz-Cruz, J. A.; Kowalko, J. E.; McGaugh, S. E.; Keene, A. C.; Ornelas-Garcia, P.
10.1101/2024.10.29.619241 — evolutionary biology — Posted on 2025-06-15
2102 Erratic Maternal Care Induces Avoidant-Like Attachment Deficits in a Mouse Model of Early Life Adversity
MacDowell Kaswan, Z.; Bowers, C.; Teplyakov, I.; Munoz-Martin, J.; Ahmed, S.; Kaffman, L.; Giuliano, L.; Dietrich, M. O.; Kaffman, A.
10.1101/2025.06.13.659607 — neuroscience — Posted on 2025-06-15
2103 Spectral Matched Filtering in the Butterfly Visuomotor System
Supple, J. A.; Cerkvenik, U.; Ilic, M.; Pirih, P.; Zkorjanc, A.; Belusic, G.; Krapp, H. G.
10.1101/2025.06.10.658887 — neuroscience — Posted on 2025-06-15
2104 PhyloControl: a phylogeny visualisation platform for risk analysis in weed biological control
Chen, S. H.; Stevens, L.; Gooden, B.; Rafter, M. A.; Knerr, N.; Thrall, P. H.; Ord, L.; Schmidt-Lebuhn, A. N.
10.1101/2025.06.11.658203 — plant biology — Posted on 2025-06-15
2105 Identification of CaVβ1 isoforms required for neuromuscular junction formation and maintenance
Vergnol, A.; Bourguiba, A.; Bauche, S.; Traore, M.; Gelin, M.; Gentil, C.; Pezet, S.; Saillard, L.; Meunier, P.; Lemaitre, M.; Perronnet, J.; Tores, F.; Gautier, C.; Guesmia, Z.; Allemand, E.; Batsche, E.; Pietri-Rouxel, F.; Falcone, S.
10.1101/2025.06.10.658789 — physiology — Posted on 2025-06-15
2109 Generalizing animal movement predictions across landscapes: a scalable framework grounded in empirical telemetry data
Chalkowski, K.; Sack, A.; Wittemyer, G.; Miller, R. S.; Boughton, R. K.; Snow, N. P.; Beasley, J. C.; Ditchkoff, S. S.; Evans, T. S.; Gray, S. M.; Lewis, J. S.; Parsons, M. A.; Vercauteren, K. C.; Webb, S. L.; Young, J. K.; Pepin, K. M.
10.1101/2025.06.12.658668 — ecology — Posted on 2025-06-15
2111 Resolving a paradox about how vision is transformed into familiarity
Bohn, S.; Hacker, C. M.; Jannuzi, B. G. L.; Meyer, T.; Hay, M.; Rust, N. C.
10.1101/2025.06.13.659490 — neuroscience — Posted on 2025-06-15
2112 CCorGsDB: A Database for Clock Correlated Genes in the Mouse and Human Central Nervous Systems
Santos, J. L. A.; Pinto, V. T. B. C.; Santos, T. E. d. S.; Coimbra, D. G.; de Andrade, T. G.
10.1101/2025.06.11.659048 — neuroscience — Posted on 2025-06-15
2114 Transient AMPK activation by nutrient stress of high fat diet preserves cardiac electrophysiological stability and protects against arrhythmias
Rudokas, M. W.; McKay, M.; Wu, X.; Granger, J. M.; Williams, Y.; Bogner, M.; Kang, T.; Seyfried, A.; Toksoy, Z.; Cacheux, M.; Young, L. H.; Akar, F. G.
10.1101/2025.06.11.658631 — physiology — Posted on 2025-06-15
2116 AI-Guided Design and AKT3 Degradation Synergize to Enhance Bispecific and Trispecific CAR-T Cell Persistence and Overcome Antigen Escape
Ansari, M. S.; Chauhan, V.; Akhtar, A.; Chaudhary, N.; Tyagi, R.; Divya, ; Husain, K.; Singh, A.; Sharma, S.; Alam, R.; Md Shakir, ; Pracha, M.; Anjum, S.; Mohd Nadeem, ; Faizan, M. I.; Azmi, I.; Iyer, A. R.; Gupta, P.; Nafiz, M.; Ali, S.; Ud din, I. M.; Javid, M.; Kuma P, H.; Srivastava, A. K.; Mabalirajan, U.; Mathews, V.; Ramalingam, S.; Kharya, G.; Ahmad, T.
10.1101/2025.06.12.658477 — cancer biology — Posted on 2025-06-15
2121 Capture-C MPRA: A high-throughput method to simultaneously characterize promoter interactions and regulatory activity
Arnould, C.; Keukeleire, P.; Inoue, F.; Cui, X.; An, K.; Murray, E.; Zhang, X.; Drmanac, R.; Peters, B.; Shendure, J.; Shen, Y.; Kircher, M.; Ahituv, N.
10.1101/2025.06.11.658967 — genomics — Posted on 2025-06-14
2123 Spatial autocorrelation of species diversity and distributions in time and across spatial scales
Soria, C. D.; Ortega, G. R.; Wolke, F. J. R.; Bartak, V.; Tschernosterova, K.; Bejcek, V.; Herrando, S.; Mikulas, I.; Stastny, K.; Ueta, M.; Vorisek, P.; Keil, P.
10.1101/2025.06.13.659470 — ecology — Posted on 2025-06-15
2124 Unraveling the diversity and functional potential of cyanosphere microbiomes assembled from terrestrial cyanobacteria
Palmer, B.; Couradeau, E.; Johansen, J.; Kurbessoian, T.; Ortega Carranza, J.; Stajich, J. E.; Ward, R.; Pietrasiak, N.
10.1101/2025.06.10.658773 — ecology — Posted on 2025-06-15
2125 Cell type specific CaMKII activation patterns revealed by CaMKAR, a bioactivity reporter deployable in living cells
Severino, A.; Reyes Gaido, O. E.; Liu, B.; Lopez-Cecetaite, G. A.; Wei, A.-C.; Rosales-Soto, G.; Hernandez-Ochoa, E. O.; Luczak, E. D.
10.1101/2025.06.11.658946 — molecular biology — Posted on 2025-06-15
2126 Teleost-specific ictacalcins exhibit similar structural organization, cation-dependent activation and transcriptional regulation as human S100 proteins
Hernandez, L.; Paris, T.; Demou, M.; Birck, C.; Begon-Pescia, C.; Rodriguez-Vidal, J. F.; Tyrkalska, S.; Bureau, C.; Gonzalez, C.; Gracia, J.; Lelievre, E.; Mulero, V.; Chi, M. N.; YATIME, L.
10.1101/2025.06.10.658860 — immunology — Posted on 2025-06-14
2127 An open dataset of cerebral tau deposition in young healthy adults based on MK6240 positron emission tomography
Lam, J.; Rodriguez-Cruces, R.; Arafat, T.; Royer, J.; Chen, J.; Dascal, A.; Sahlas, E.; Pana, R.; Hopewell, R.; Hsiao, C. H.-H.; Massarweh, G.; Soucy, J.-P.; Villeneuve, S.; Caciagli, L.; Koepp, M.; Bernasconi, A.; Bernasconi, N.; Bernhardt, B.
10.1101/2025.06.13.655622 — neuroscience — Posted on 2025-06-14
2130 Sexually-dimorphic neurons in the Drosophila whole-brain connectome
Deutsch, D.; Matsliah, A.; Wang, K.; Dorkenwald, S.; Mondal, A.; Burke, A.; Hebditch, J.; Gager, J.; Yu, S.-C.; Sterling, A.; MkKellar, C.; Schlegel, P.; Gerhard, S.; Sterne, G.; Costa, M.; Eichler, K.; Yin, Y.; Jefferis, G. S. X. E.; Seung, H. S.; Murthy, M.
10.1101/2025.06.10.658788 — neuroscience — Posted on 2025-06-14
2131 Cocaine withdrawal enhances subthalamic reward sensitivity
Williams, M.; Vielle, C.; de Peretti, J.-L.; Tiran-Cappello, A.; Melon, C.; Awada, A.; Pelloux, Y.; Maurice, N.; BAUNEZ, C.; Degoulet, M.
10.1101/2025.06.10.658581 — neuroscience — Posted on 2025-06-14
2134 Decoupling simultaneous motor imagination and execution via orthogonal ECoG neural representations
Pollina, L.; Struber, L.; de Seta, V.; Russo, E.; Karakas, S.; Chabardes, S.; Aksenova, T.; Charvet, G.; Shokur, S.; Micera, S.
10.1101/2025.06.13.659445 — neuroscience — Posted on 2025-06-14
2135 Fos labels a distinct excitatory neuron ensemble for memory retrieval
Ding, N.; Sun, Q.; Wu, C.; Xiao, Y.; Li, Y.; Wang, X.; Shu, Y.; Yuan, P.
10.1101/2025.06.14.659414 — neuroscience — Posted on 2025-06-14
2136 Biomarkers in cerebrospinal fluid sediments
Alsina, R.; Riba, M.; Sartorio, M.; Romera, C.; Vilaplana, B.; Prats, E.; Molina-Porcel, L.; del Valle, J.; Pelegri, C.; Vilaplana, J.
10.1101/2025.06.10.657984 — neuroscience — Posted on 2025-06-14
2137 A CRISPR-CAS9 high throughput machine-learning platform for modulation of genes involved in Parkinson's disease-associated PINK1-mitophagy in iPSC-derived dopaminergic neurons
Soutar, M. P. M.; Carbone, B.; Kindalova, P.; Mehrizi, R.; Lopes, F. M.; Lam, N.; Rockliffe, A.; Braybrook, T.; Taylor, M.; Nguyen, C.; Ducotterd, F.; Reith, A. D.; Mohamet, L.; Plun-Favreau, H.
10.1101/2025.06.10.658840 — neuroscience — Posted on 2025-06-15
2139 Mapping 3D Heterogeneity of Thyroid Tumors Using Micro-CTbased Radiomics
Tajbakhsh, K.; Stanowska, O.; Buljan, M.; Neels, A.; Perren, A.; Zboray, R.
10.1101/2025.06.13.658854 — pathology — Posted on 2025-06-14
2140 Spatial analysis reveals a novel inflammatory tumor transition state which promotes a macrophage-driven induction of sarcomatoid renal cell carcinoma
May, A. M.; Kadomoto, S.; Williams, C.; Soupir, A. C.; The, S.; McGue, J. J.; Robinson, T.; Shelley, G.; Hayes, M. T.; Fridley, B. L.; Balasi, J. A.; Ramos Echevarria, P. M.; Dhillon, J.; Nallandhighal, S.; Acharyya, S.; Chen, L.; Aldous, J.; Schurman, N.; Baladandayuthapani, V.; Frankel, T. L.; Salami, S. S.; Manley, B. J.; Mehra, R.; Udager, A. M.; Keller, E. T.
10.1101/2025.06.12.656421 — cancer biology — Posted on 2025-06-14
2141 Breaking Through Biology's Data Wall: Expanding the Known Tree of Life by Over 10x using a Global Biodiscovery Pipeline
Vince, O.; Oldach, P.; Pereno, V.; Leung, M. H. Y.; Greco, C.; Minto-Cowcher, G.; Ur-Rehman, S.; Kam, K. Y. K.; Chow, W.; Bolton, E.; Mwambingu, B. R.; Greenhalgh, N. L.; Knot, I. E.; Christoffersen, L.; Clark, M.; Pecoraro, R.; Kollasch, A. W.; Bohnuud, T.; Bakalar, M.; Lorenz, P.; Gowers, G.
10.1101/2025.06.11.658620 — genomics — Posted on 2025-06-14
2144 Engineered AAV9 as in vivo gene delivery platform for the selective transduction of TME cell subsets
Demircan, M. B.; Strassheimer, F.; Zinser, L. J.; Elleringmann, P.; John, F.; Thalheimer, F. B.; Steinbach, J. P.; Oellerich, T.; Burger, M. C.; Buchholz, C. J.
10.1101/2025.06.11.658408 — bioengineering — Posted on 2025-06-14
2149 Rational Generation of Monoclonal Antibodies and Intrabodies Selective for Pathogenic TDP-43
Zhao, B.; Louadi, S.; Coutts, J. A.; Gibbs, E.; Huang, M. Y.; Marina, R. J.; Aigner, S.; Alam, P.; DeMarco, M. L.; Mackenzie, I. R.; Djikstra, A. A.; Caughey, B.; Yeo, G. W.; Kaplan, J. M.; Cashman, N. R.
10.1101/2025.06.10.658846 — immunology — Posted on 2025-06-14
2150 Mitochondrial Bioenergetic Failure in SLE Immunocytes: Targeting Fitness for Therapy
Yennemadi, A. S.; Jordan, N.; Diong, S.; Little, M.; Keane, J.; Leisching, G.
10.1101/2025.06.10.658845 — immunology — Posted on 2025-06-14
2152 All-Atom Protein Sequence Design using Discrete Diffusion Models
Villegas-Morcillo, A.; Admiraal, G. J.; Reinders, M. J. T.; Weber, J. M.
10.1101/2025.06.13.659451 — bioinformatics — Posted on 2025-06-14
2154 Cell-free RNA reveals host and microbial correlates of broadly neutralizing antibody development against HIV
Kowarsky, M.; Moufarrej, M. N.; Okamoto, J.; Xie, Y.; Neff, N. N.; Abdool Karim, S. S.; Garrett, N. J.; Moore, P. L.; Camunas-Soler, J.; Quake, S. R.
10.1101/2025.06.10.658831 — genomics — Posted on 2025-06-14
2157 The metabolic kinase LKB1 shapes the enteric nervous system bymitigating the oxidative stress and p53 activity
Lucas, A.; Appaix, F.; Allard, J.; Mevel-Aliset, M.; Radu, A. G.; Fauvelle, F.; Favier, B.; Grichine, A.; Maurer, J.; Hainaut, P.; Attardi, L. D.; Billaud, M.; Torch, S.; Thibert, C.
10.1101/2025.06.10.658770 — developmental biology — Posted on 2025-06-14
2158 Epigenetic regulation of cilia stability and kidney by the chromatin remodeling SWI/SNF complexes
Cheng, X.; Zhu, Q.; Ma, S.; Peng, X.; Huang, G.; Liu, g.; Zhang, W.; Zhang, Y.; Jiang, C.; Qiu, A.; Cao, Y.
10.1101/2025.06.10.658863 — developmental biology — Posted on 2025-06-14
2159 Self-amplifying mRNA expression is governed by mitochondrial machinery and ACSL4
F. Tshering, L.; Wang, C.; Xiang, Q.; Kundu, S.; Solorzano, A.; Chaparro-Riggers, J.; Lin, L.; Paksa, A.
10.1101/2025.06.13.659366 — molecular biology — Posted on 2025-06-14
2160 Accumulation of SA-βGal High Cells in Human Naive T Cell Compartments Reveals a Stress-Adapted, Senescent-Like State
Alexandru, A. C.; Hormazabal, G. V.; Matsui, H.; Kasler, H.; Lore, S.; Aguirre, C. G.; Roberts, A.; Heckenbach, I. J.; Tiwari, R.; Kwok, R.; Becker, S.; Verdin, E.
10.1101/2025.06.10.658841 — immunology — Posted on 2025-06-14
2163 Multi-selective RAS(ON) Inhibition Targets Oncogenic RAS Mutations and Overcomes RAS/MAPK-Mediated Resistance to FLT3 and BCL2 Inhibitors in Acute Myeloid Leukemia
Popescu, B.; Jones, M. F.; Piao, M.; Tran, E.; Koh, A.; Lomeli, I.; Peretz, C. A. C.; Murad, N.; Abelson, S.; Morales, C.; Rivera, J. M.; Pikman, Y.; Cheng, M. L.; Logan, A. C.; Stieglitz, E.; Smith, C. C.
10.1101/2025.06.10.658786 — cancer biology — Posted on 2025-06-14
2164 A computational analysis of the glycoprotein LRP1 structure and the role of glycans as quaternary glue
Tuveri, G. M.; Basile, M.; Acosta Gutierrez, S.; Kausas, M.; Tian, X.; Franzese, G.; Ruiz Perez, L.; Battaglia, G.
10.1101/2025.06.10.658798 — biophysics — Posted on 2025-06-14
2167 Local optogenetic control of genome editing and tumorigenesis in vivo using wireless implantable optoelectronics
Bansal, T.; Lee, M.-K.; Coleman, C.; Kim, Y.-M.; Chen, Y.; Haney, C. R.; David, O.; Sreekanth, V.; Avila, R.; Matsche, J.; Vijeth, S.; Hintermueller, D.; Yamagishi, K.; Kang, J.; Mowry, K.; Kim, M.; Liu, Y.; Toth, P. T.; Lee, S. S.-Y.; Loh, S.; Clark, S.; Huynh, H.; Kim, Y.; Banks, A. R.; Huang, Y.; Good, C. H.; Rehman, J.; Rogers, J. A.; Karginov, A. V.
10.1101/2025.06.12.659214 — bioengineering — Posted on 2025-06-14
2171 Swine reporter model for preclinical evaluation and characterization of gene delivery vectors
Campbell, J.; Korpela, D.; Han, H.; Zhao, S.; Webster, D.; Nguyen, Y. A.; Aune, R.; Dagan, H.; Milliken, R.; Watts, J.; Murthy, N.; Carlson, D.
10.1101/2025.06.13.659546 — genetics — Posted on 2025-06-14
2177 Vicennial metagenomic time series unveils evolutionary dynamics of giant viruses in a freshwater ecosystem
Vasquez, Y.; Romero-Gutierrez, M. F.; Bower, R.; Rohwer, R. R.; McMahon, K.; Woyke, T.; Schulz, F.
10.1101/2025.06.13.655548 — microbiology — Posted on 2025-06-14
2179 Mitochondrial calcium influx-driven bioenergetics in the dopaminergic system selectively enable drug reward
Gao, J.; Zhao, H.; Han, X.; Zeng, L.; Liu, G.; Wei, X.; Liu, C.; Wu, W.; Chen, S.; Chen, J.; Li, T.; Yin, J.; Zhou, T.; Zhang, X.-M.; Li, A.-L.; Li, T.; Pan, X.
10.1101/2025.06.10.658191 — neuroscience — Posted on 2025-06-14
2182 MMP release following cartilage injury leads to collagen loss in intact tissue - a computational study
Hamada, M. A.; Eskelinen, A. A.; Kosonen, J. P.; Florea, C.; Grodzinsky, A.; Tanska, P.; Korhonen, R. K.
10.1101/2025.06.10.658780 — biophysics — Posted on 2025-06-14
2189 Epigenetic reprogramming of autophagy leads to uncovering a novel therapeutic target for mutant IDH1 astrocytomas
Nunez, F. J.; Banerjee, K.; Mujeeb, A. A.; Mauser, A.; Tronrud, C. E.; Zhu, Z.; Raghuram, S.; Sheth, M. R.; Pena Agudelo, J. A.; Zelaya, J.; Taher, A.; Kadiyala, P.; Carney, S. V.; Garcia-Fabiani, M. B.; Comba, A.; Alghamri, M. S.; McClellan, B. L.; Faisal, S. M.; Nwosu, Z. C.; Hong, H. S.; Sajjakulnukit, P.; Qin, T.; Sartor, M. A.; Ljungman, M.; Welch, J. D.; Cheng, S.-Y.; Lowenstein, P. R.; Lahann, J.; Lyssiotis, C. A.; Castro, M.
10.1101/2024.03.08.584091 — cancer biology — Posted on 2025-06-14
2194 Genomic comparisons shed light on the adaptive basis of brain size plasticity and chromosomal instability in the Eurasian common shrew
Thomas, W. R.; Lama, T. M.; Moreno-Santillan, D.; Farre, M.; Baldoni, C.; Abueg, L.; Balacco, J.; Fedrigo, O.; Formenti, G.; Jain, N.; Mountcastle, J.; Tilley, T.; Tracey, A.; Ray, D. A.; Dechmann, D. K. N.; von Elverfeldt, D.; Nieland, J.; Corthals, A. P.; Jarvis, E.; Davalos, L. M.
10.1101/2025.04.11.648246 — evolutionary biology — Posted on 2025-06-14
2199 A global map of the Zika virus phosphoproteome reveals host-driven regulation of viral budding and cytopathogenicity
Manuelyan, I.; Schmoker, A. M.; Yount, B. L.; Eisenhauer, P.; Keller, J. I.; Gold, C.; Terino, D.; Ziegler, C. M.; Alexander, J.; Driscoll, H. E.; Hutchinson, E.; Bhella, D.; Syme, C. D.; Widman, D. G.; Heise, M. T.; Baric, R. S.; Ballif, B. A.; Botten, J. W.
10.1101/2021.11.24.469793 — microbiology — Posted on 2025-06-14
2200 HIV broadly neutralizing antibody escape dynamics drive the outcome of AAV vectored immunotherapy in humanized mice
Galvez, N. M. S.; Nitido, A. D.; Yoo, S. B.; Cao, Y.; Deal, C. E.; Boutros, C. L.; MacDonald, S. W.; Soto Albrecht, Y. E.; Lam, E. C.; Sheehan, M. L.; Parsons, D.; Lin, A. Z.; Deymier, M. J.; Brady, J. M.; Moon, B.; Bullock, C. B.; Tanno, S.; Pegu, A.; Chen, X.; Liu, C.; Koup, R. A.; Mascola, J. R.; Vrbanac, V. D.; Lingwood, D.; Balazs, A. B.
10.1101/2024.07.11.603156 — microbiology — Posted on 2025-06-14
2201 The Ambiguous Genetic Code of Methanogenic Archaea that Grow on Methylamines
Shalvarjian, K. E.; Chadwick, G.; Perez, P. I.; Woods, P.; Orphan, V. J.; Nayak, D. D.
10.1101/2025.06.11.659114 — microbiology — Posted on 2025-06-14
2202 Clover-like object vector representations support human spatial cognition
Becu, M.; Krasovec, I. M.; Saldanha, P.; Whitlock, J.; Doeller, C. F.
10.1101/2025.04.18.649400 — neuroscience — Posted on 2025-06-14
2204 Humanized Caffeine-Inducible Systems for Controlling Cellular Functions
Scheller, L.; Elia, M.; Bonati, L.; Kang, C.; Gainza, P.; Garodia, Y.; Deshpande, P.; Schmidt, J.; Georgeon, S.; Tang, L.; Correia, B.
10.1101/2025.06.13.659463 — synthetic biology — Posted on 2025-06-14
2210 Development and extensive sequencing of a broadly-consented Genome in a Bottle matched tumor-normal pair
McDaniel, J. H.; Patel, V.; Olson, N. D.; He, H.-J.; He, Z.; Cole, K. D.; Gooden, A. A.; Schmitt, A.; Sikkink, K.; Sedlazeck, F.; Doddapaneni, H.; Jhangiani, S. N.; Muzny, D. M.; Gingras, M.-C.; Mehta, H.; Paulin, L. F.; Hastie, A. R.; Yu, H.-C.; Weigman, V.; Rojas, A.; Kennedy, K.; Remington, J.; Salas-Gonzalez, I.; Sudkamp, M.; Wiseman, K.; Lajoie, B. R.; Levy, S.; Jain, M.; Akeson, S.; Narzisi, G.; Steinsnyder, Z.; Reeves, C.; Shelton, J.; Kingan, S. B.; Lambert, C.; Bayabyan, P.; Wenger, A. M.; McLaughlin, I. J.; Adamson, A.; Kingsley, C.; Wescott, M.; Kim, Y.; Paten, B.; Park, J.; Violich
10.1101/2024.09.18.613544 — genomics — Posted on 2025-06-14
2215 A high-fidelity in vitro model of the human intestinal epithelium
Fujii, S.; Espenschied, S. T.; Anand, V.; Bettencourt-Silva, J.; Han, Y.; Ito, G.; Koseki, A.; Kosugi, A.; Kozlowski, J.; Matsumoto, R.; Meng, S.; Mulligan, N.; Musich, R. J.; Newhall, K.; Ohshina, E.; Sekiguchi, S.; Wang, Y.; Hu, J.; Ciorba, M. A.; Sibley, L. D.; Okamoto, R.; Stappenbeck, T. S.
10.1101/2024.01.01.573838 — cell biology — Posted on 2025-06-14
2216 A single amino acid variant in the variable region I of AAV capsid confers liver detargeting
Xing, R.; Xu, M.; Reil, D.; Destefano, A.; Cui, M.; Liu, N.; Liang, J.; Xu, G.; Luo, L.; Xu, M.; Zhang, F.; Tai, P. W.; Wei, Y.; Gruntman, A. M.; Flotte, T. R.; Gao, G.; Wang, D.
10.1101/2025.03.04.641478 — molecular biology — Posted on 2025-06-14
2217 Stable states in an unstable landscape: microbial resistance at the front line of climate change
Cronin, D. R.; Holland-Moritz, H.; Smith, D.; Aroney, S. T. N.; Hodgkins, S.; Borton, M.; Li, Y.-F.; Zayed, A.; Healy, K.; IsoGenie Field & Analytic Teams 2010-2017, ; EMERGE Institute Coordinators, ; Tfaily, M. M.; Crill, P. M.; McCalley, C.; Wrighton, K.; Varner, R. K.; Tyson, G. W.; Woodcroft, B.; Bagby, S. C.; Ernakovich, J.; Rich, V. I.
10.1101/2025.02.07.636677 — microbiology — Posted on 2025-06-14
2218 Prefrontal dopamine activity is critical for rapid threat avoidance learning
Zeidler, Z. E.; Gomez, M. F.; Gupta, T.; Shari, M.; Wilke, S. A.; DeNardo, L. A.
10.1101/2024.05.02.592069 — neuroscience — Posted on 2025-06-14
2219 Neurally-informed modelling unravels a single evidence accumulation process for choices and subsequent confidence reports
Grogan, J. P.; Vermeylen, L.; Mannion, S.-L.; McCabe, C.; Monakhovych, D.; Desender, K.; O'Connell, R. G.
10.1101/2025.06.05.658071 — neuroscience — Posted on 2025-06-14
2220 A Brain Reward Circuit Inhibited By Next-Generation Weight Loss Drugs
Godschall, E. N.; Gungul, T. B.; Sajonia, I. R.; Buyukaksakal, A. K.; Li, O. D.-A.; Ogilvie, S.; Keeler, A. B.; Tian, G.; Koita, O.; Shi, Y.; Deutsch, T. C. J.; Crook, M.; Zhang, Y.; Conley, N. J.; Webster, A. N.; Calhan, O. Y.; Liu, W.; Akkoub, A.; Malik, K.; West, K. I.; Michel-Le, S.; Karthikeyan, A.; van Gerven, G.; Beier, K. T.; Zweifel, L. S.; Patel, M. K.; Campbell, J. N.; Deppmann, C. D.; Guler, A. D.
10.1101/2024.12.12.628169 — neuroscience — Posted on 2025-06-14
2221 CrHCF244 is required for psbA translation in Chlamydomonas reinhardtii
Wang, X.; Wang, G.; Cheramie, L. A.; Zhao, C.; Dassanayake, M.; Moroney, J. V.; Vinyard, D. J.
10.1101/2024.05.30.596694 — plant biology — Posted on 2025-06-14
2225 Distinct Cellular Phenotypes of Language and Executive Decline in Amyotrophic Lateral Sclerosis
Petrescu, J.; Roque, C. G.; Jackson, C.; Daly, A.; Kang, K.; Casel, O.; Leung, M.; Reilly, L.; Eschbach, J.; McDade, K.; Gregory, J. M.; Bonneau, R.; Smith, C.; Phatnani, H.
10.1101/2025.02.26.640433 — genomics — Posted on 2025-06-14
2226 Neuronal Autophagy Failure Drives α-Synuclein Transfer to Microglia to Outsource Aggregate Clearance
Chakraborty, R.; Samella, P.; Testa, V.; Montero-Munoz, J.; Nonaka, T.; Hasegawa, M.; Consiglio, A.; Zurzolo, C.
10.1101/2024.04.19.590207 — cell biology — Posted on 2025-06-14
2228 The single-particle structures of a Bacterial Cyanide Dihydratase and a Fungal Cyanide Hydratase
Justo Arevalo, S.; Felice, V. V.-R.; Acuna, M. B.; Flores, K. O.; Aguilar, M. Q.; Balan, A.; Farah, C. S.
10.1101/2025.06.11.659212 — biochemistry — Posted on 2025-06-12
2229 An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function
Jame-Chenarboo, Z.; Schmidt, E. N.; Crichton, M.; Takahashi-Yamashiro, K.; Lima, G. M.; Luna-Dulcey, L.; Jung, J.; Ivison, S.; St. Laurent, C. D.; Enterina, J. R.; Lin, S.-Y.; Sarkar, S.; John, R.; Nanjappa, S. G.; Malaker, S. A.; Levings, M. K.; Marth, J. D.; Derda, R.; Macauley, M. S.
10.1101/2025.06.10.658684 — biochemistry — Posted on 2025-06-12
2230 High-resolution cryo-EM analysis of the therapeutic Pseudomonas phage Pa223
Hou, C.-F. D.; Bellis, N.; Lokareddy, R. K.; Branston, S.; Reid, J.; Geier, R.; Soriaga, A.; Sim, L.; Kyme, P.; Birx, D.; Lemire, S.; Cingolani, G.
10.1101/2025.06.11.659172 — biochemistry — Posted on 2025-06-12
2233 Examining the Effect of Social Determinants of Health on Human Trait Heritability
Risse-Adams, O. S.; Liquori, J. L.; Sinnott-Armstrong, N.; Musharoff, S. A.
10.1101/2025.06.12.659317 — genetics — Posted on 2025-06-13
2234 Species-specific responses to paleoclimatic changes and landscape barriers drive contrasting phylogeography of co-distributed lemur species in northeastern Madagascar
van Elst, T.; Schüssler, D.; Rafamantanantsoa, S. M.; Radriarimanga, T.; Rabemananjara, N. R.; Rasolofoson, D. W.; Randimbiharinirina, R. D.; Hohenlohe, P. A.; Radespiel, U.
10.1101/2025.06.11.658897 — evolutionary biology — Posted on 2025-06-13
2236 Foraging competence and scrounging tolerance enhance social relationships in a socially tolerant wild primate
Karakoc, E.; Vogg, R.; Michele, M.; Petersdorff-Campen, J.; Ecker, A. S.; Kappeler, P. M.; Fichtel, C.
10.1101/2025.06.12.659242 — ecology — Posted on 2025-06-13
2242 The bacterial ESCRT-III PspA rods thin lipid tubules and and increase membrane curvature through helix α0 interactions
Hudina, E.; Schott-Verdugo, S.; Junglas, B.; Kutzner, M.; Ritter, I.; Hellmann, N.; Schneider, D.; Gohlke, H.; Sachse, C.
10.1101/2025.06.13.659447 — biophysics — Posted on 2025-06-13
2243 HiFIseek: gene-specific enrichment of high-impact mutations in associated genomic regions
Riudavets Puig, R.; Brorson, I. S.; O'Mahony, D.; Kristensen, V. N.; Mathelier, A.
10.1101/2025.06.12.659305 — bioinformatics — Posted on 2025-06-13
2244 Human CXCL17 Activates and Binds to Fish GPR25 Orthologs
Hu, W.-F.; Wang, J.-J.; Yu, J.; Yao, J.-J.; Liu, Y.-L.; Xu, Z.-G.; Guo, Z.-Y.
10.1101/2025.06.10.658772 — biochemistry — Posted on 2025-06-13
2245 Spatially-explicit genomics of An. gambiae s.l uncovers fine-scale population structure and mechanisms of insecticide resistance
Nagi, S. C.; Essandoh, J.; Ato-Egyir, N.; Lucas, E. R.; Miles, A.; Desewu, K.; Williams, I.; Egyir-Yawson, A.; Sedda, L.; Weetman, D.; Donnelly, M. J.
10.1101/2025.06.13.655782 — genomics — Posted on 2025-06-13
2248 White matter micro- and macrostructural properties in midlife individuals at risk for Alzheimer's disease: Associations with sex and menopausal status
Raikes, A. C.; Dyke, J. P.; Nerattini, M.; Boneu, C.; Ajila, T.; Fauci, F.; Battista, M.; Pahlajani, S.; Williams, S.; Brinton, R. D.; Mosconi, L.
10.1101/2025.06.09.658686 — neuroscience — Posted on 2025-06-13
2249 Phosphorylation-inducing chimera rewires oncogenic kinase to trigger apoptosis
Merz, M. M.; Shoba, V. M.; Pergu, R.; Severance, Z. C.; Munkanatta Godage, D. N. P.; Deb, A.; Kwok, H. S.; Singh, P.; Singh, S.; Allen, J. B.; Tian, W.; Gosavi, P. M.; Chaudhary, S. K.; Anokhina, V.; Weisberg, E. L.; Payne, N. C.; He, Y.; Osadchey, R.; Shekhar, M.; Mazitschek, R.; Rees, M. G.; Roth, J. A.; Cui, Q.; Griffin, J. D.; Liau, B. B.; Choudhary, A.
10.1101/2025.06.13.659082 — synthetic biology — Posted on 2025-06-13
2250 Humanized Caffeine-Inducible Systems for Controlling Cellular Functions
Scheller, L.; Correia, B.; Elia, M.; Kang, C.; Bonati, L.; Gainza, P.; Garodia, Y.; Deshpande, P.; Schmidt, J.; Georgeon, S.; Tang, L.
10.1101/2025.06.13.659463 — synthetic biology — Posted on 2025-06-13
2251 Titania Nanoparticle Regulate Innate Immunity
Whittaker, J. J.; Eikrem, D.; Seisenbaeva, G. A.; Fromell, K.; Ekdahl, K. N.; Nilsson, B.; Sandgren, M.; Kessler, V. G.
10.1101/2025.06.13.658543 — biochemistry — Posted on 2025-06-13
2256 MORC2 directs transcription-dependent CpG methylation of human LINE-1 transposons in early neurodevelopment
Dorazehi, F.; Francesconi, C.; Pandiloski, N.; Castilla-Vallmanya, L.; Albecka, A.; Koutounidou, S.; Mohan, S. B.; Adami, A.; Katsikas, A.; Matijevic, J.; Karlsson, O.; Davis-Hansson, C.; Johansson, J. G.; Modis, Y.; Jakobsson, J.; Douse, C. H.
10.1101/2025.06.11.658943 — molecular biology — Posted on 2025-06-13
2260 Toward Essential Oil Stewardship Strain-Resolved Evaluation of Thyme Oil Activity Against Pseudomonas aeruginosa
Brozyna, M.; Stepnicka, Z.; Tyminska, N.; Dudek, B.; Kapczynska, K.; Matkowski, A.; Sun, Y.; Junka, A.
10.1101/2025.06.13.659493 — microbiology — Posted on 2025-06-13
2263 The mPFC molecular clock mediates the effects of sleep deprivation on depression-like behavior and regulates sleep consolidation and homeostasis
Gardner, W.; Sarrazin, D. H.; Balzinger, M.; Marchese, C.; Ragno, A.; Ramanathan, C.; Veleanu, M.; Vestring, S.; Normann, C.; Bourgin, P.; Serchov, T.
10.1101/2025.06.09.658701 — neuroscience — Posted on 2025-06-13
2264 Cancer systems immunology reveals myeloid - T cell interactions and B cell activation mediate response to checkpoint inhibition in metastatic breast cancer
Gonzalez, E.; Kreger, J.; Liu, Y.; Wu, X.; Barbetta, A.; Baugh, A.; Al-Zubeidy, B.; Jang, J.; Shin, S. M.; Jacobo, M.; Stearns, V.; Connolly, R. M.; Ho, W.; Emamaullee, J.; MacLean, A. L.; Roussos Torres, E. T.
10.1101/2025.06.09.658361 — cancer biology — Posted on 2025-06-13
2266 AbDesign: Database of point mutants of antibodies with associated structures reveals poor generalization of binding predictions from machine learning models.
Janusz, B.; Chomicz, D.; Demharter, S.; Arts, M.; Kanter, J. d.; Wilke, Y.; Britze, H.; Wrobel, S.; Gawlowski, T.; Dudzic, P.; Ukkivi, K.; Peil, L.; Spreafico, R.; Krawczyk, K.
10.1101/2025.06.09.658639 — bioinformatics — Posted on 2025-06-13
2268 Thermally controlled state switches for macrophage immunotherapy
Liu, A.; Farooq, A. S.; Abedi, M. H.; Smith, C. A. B.; Wu, D.; Shapiro, M. G.
10.1101/2025.06.09.658763 — bioengineering — Posted on 2025-06-13
2269 Metabolism of epigenetic ribonucleosides leads to nucleolar stress and cytotoxicity
Sun, X.; Donlic, A.; Boyer, J. A.; Reddy, N.; Brangwynne, C. P.; Rabinowitz, J. D.; Kleiner, R. E.
10.1101/2025.06.11.659152 — biochemistry — Posted on 2025-06-13
2271 Proteomics- and BRET-screens identify SPRY2 as Ras effector that impacts its membrane organisation
Pavic, K.; Hood, F. E.; Duval, C. J.; Manoharan, G. b.; Laurini, C.; Siddiqui, F. A.; Mo, S. P.; Prior, I. A.; Abankwa, D.
10.1101/2025.06.13.659437 — biochemistry — Posted on 2025-06-13
2273 SARS-CoV-2 envelope protein induces LC3 lipidation via the V-ATPase-ATG16L1 axis
Figueras-Novoa, C.; Timimi, L. J.; Marcassa, E.; Taveira-Marques, R.; Adams, L.; Jiang, M.; Wu, M. Y.; Montaner, B.; Ng, K.; De Lorenzo, G.; Furnon, W.; Cowton, V. M.; Upfold, N.; Kassiotis, G.; Harvey, R.; Patel, A. H.; Howell, M.; Ulferts, R.; Beale, R.
10.1101/2025.06.12.659257 — cell biology — Posted on 2025-06-13
2274 Molecular Mechanisms of DNMT3A-3L-Mediated de novo DNA Methylation on Chromatin
Yan, Y.; Zhou, X. E.; Thomas, S. L.; Liu, M.; Lai, G.-Q.; Worden, E. J.; Jones, P. A.; Xu, T.-H.
10.1101/2025.06.10.658647 — molecular biology — Posted on 2025-06-13
2275 Digital PCR detection of Mycobacterium tuberculosis and HIV-1 co-localization in spinal tuberculosis biopsies
Waters, R.; Martineau, A.; Laubscher, M.; Dunn, R. N.; Held, M.; Abrahams, M.-R.; Coussens, A. K.
10.1101/2025.06.11.659223 — molecular biology — Posted on 2025-06-13
2277 Scavenger Receptor class F member 2 is an intracellular receptor for Hepatitis B virus
Li, C.; Wang, Y.; Xiong, R.; Li, Q.; Zhou, Z.; Liu, Q.; Qi, Y.; Gao, Z.; Xu, G.; Fang, L.; Sun, Y.; Farzan, M.; Choe, H.; Sui, J.; Li, W.
10.1101/2025.06.13.659407 — microbiology — Posted on 2025-06-13
2278 Microbial Worlds Apart: Distinct Communities in Crude Oil and Production Waters
Alibrandi, A.; Plewka, J.; Vuillemin, A.; Bartholomaeus, A.; di Primio, R.; Probst, A. J.; Kallmeyer, J.
10.1101/2025.06.13.658281 — microbiology — Posted on 2025-06-13
2280 Experience-dependent sharp-wave ripple deficits in an Alzheimer's disease mouse model
Schnur, P.; Byron, N.; Gerasimou, S.; Pascual Clavel, A.; Rohner, V.; Patriarchi, T.; Sakata, S.
10.1101/2025.06.09.658771 — neuroscience — Posted on 2025-06-13
2282 Lipid droplet dysmetabolism affects cell homeostasis in an in vitro model of Alzheimer disease
Fernandes, T.; Caldeira, M.; Melo, T.; Neves, B. B.; Carvalho, C.; Resende, R.; Filadi, R.; Pizzo, P.; Domingues, M. R.; Pereira, C. F.; Moreira, P. I.
10.1101/2025.06.09.658644 — neuroscience — Posted on 2025-06-13
2283 Caffeine-regulated molecular switches for functional control of CAR T cells in vivo
Sylvander, E.; Salzer, B.; Emminger, D.; Baik, H.; D'Accardio, G.; Schaefer, M.; Mouratidis, K.; Buri, M. C.; Maresch, D.; Urbanetz, A.; Seigner, J.; Marchiori, E.; Munoz-Lopez, A.; Engert, F.; Engels, B.; Mittelstaet, J.; van der Veeken, J.; Rosato, A.; Zuber, J.; Putz, E. M.; Zajc, C. U.; Lehner, M.; Traxlmayr, M. W.
10.1101/2025.06.13.659487 — synthetic biology — Posted on 2025-06-13
2284 Altered kinematics and muscle activities during half squats in people with ankle sprain history
Matsumura, U.; Tsurusaki, T.; Ogusu, R.; Yamamoto, S.; Lee, Y.; Sunagawa, S.; Koseki, H.
10.1101/2025.06.10.658971 — physiology — Posted on 2025-06-13
2288 Metagenomic enables the first detection of Trypanosoma sp. in Streblidae (Diptera: Hippoboscoidea) parasitizing bats in Sao Paulo, Brazil.
Marcatti, R. d. A.; Franco, L. A. M.; Rocha, E. C.; Nardi, M. S.; Summa, J. L.; da Silva, E. T. B. C.; da Rosa, A. R.; de Oliveira, D. C.; Graciolli, G.; Sabino, E. C.
10.1101/2025.06.12.659397 — microbiology — Posted on 2025-06-12
2289 Fast Evolution of SOS-Independent Multi-Drug Resistance in Bacteria
Zhang, L.; Guan, Y.; Cheng, Y. Y.; Cokcetin, N. N.; Bottomley, A.; Robinson, A.; Harry, E.; van Oijen, A. M.; Su, Q. P.; Jin, D.
10.1101/2022.03.29.486198 — microbiology — Posted on 2025-06-13
2290 HAVEN: Hierarchical Attention for Viral protEin-based host iNference
Antony, B.; Haghani, M.; Lauring, A. S.; Karpatne, A.; Murali, T. M.
10.1101/2025.06.09.658367 — bioinformatics — Posted on 2025-06-13
2291 Inference of single cell profiles from histology stains with the Single-Cell omics from Histology Analysis Framework (SCHAF)
Comiter, C.; Chen, X.; Vaishnav, E. D.; Kobayashi-Kirschvink, K. J.; Ciapmricotti, M.; Zhang, K.; Murray, J.; Monticolo, F.; Qi, J.; Tanaka, R.; Brodowska, S. E.; Li, B.; Yang, Y.; Rodig, S. J.; Karatza, A.; Quintanal Villalonga, A.; Turner, M.; Pfaff, K. L.; Jane-Valbuena, J.; Slyper, M.; Waldman, J.; Vigneau, S.; Wu, J.; Blosser, T. R.; Segerstolpe, A.; Abravanel, D.; Wagle, N.; Demehri, S.; Zhuang, X.; Rudin, C. M.; Klughammer, J.; Rozenblatt-Rosen, O.; Stultz, C. M.; Shu, J.; Regev, A.
10.1101/2023.03.21.533680 — bioinformatics — Posted on 2025-06-13
2292 Generative prediction of real-world prevalent SARS-CoV-2 mutation with in silico virus evolution
Liu, X.; Nie, Z.; Si, H.; Shen, X.; Liu, Y.; Huang, X.; Dong, T.; Xu, F.; Ren, Z.; Zhou, P.; Chen, J.
10.1101/2024.11.28.625962 — evolutionary biology — Posted on 2025-06-13
2295 Decoding Cellular Stress States for Toxicology Using Single-Cell Transcriptomics
Shah, I.; Gallegos, D.; Robinette, B.; Chambers, B. A.; Eastburn, D.; Camiolo, S.; White, K.; Martin, N.; Montis, G.; McComb, J.; Seligmann, B.; Chorley, B. N.
10.1101/2025.06.10.657506 — pharmacology and toxicology — Posted on 2025-06-13
2296 Composition of Carotid Plaques Differs Between Chinese and United States Patients: A Histology Study
Cao, J.-L.; Ferguson, M.; Sun, J.; shen, M.; Small, R. C.; Hippe, D. S.; Zhao, X.; Zhang, D.; Watase, H.; Yuan, C.; Gao, P.-y.; Demarco, J. K.; Nicosia, R. F.; Wang, Y.-J.; Li, H.-W.; Li, Z.-R.; Wang, Y.; Kohler, T. R.; Hatsukami, T.; Sui, B.
10.1101/2025.06.10.658993 — pathology — Posted on 2025-06-13
2297 Spatial multi-omics and deep learning reveal fingerprints of immunotherapy response and resistance in hepatocellular carcinoma
Wu, Z.; Boen, J.; Jindal, S.; Basu, S.; Bieniosek, M.; He, S.; LaPelusa, M. B.; Mayer, A. T.; Kaseb, A. O.; Zou, J.; Sharma, P.; Trevino, A. E.
10.1101/2025.06.11.656869 — cancer biology — Posted on 2025-06-13
2298 Rodents as Potential Reservoirs for Toroviruses
Buigues Bisquert, J.; Vinals, A.; Martinez-Recio, R.; Monros, J. S.; Sanjuan, R.; Cuevas, J. M.
10.1101/2025.06.12.659308 — microbiology — Posted on 2025-06-13
2306 GVB-positive neurons are resilient to tau-induced impairment of protein synthesis
Smits, J. F. M.; Ligthart, T. W.; Jorge-Oliva, M.; Middelhoff, S.; Schipper, F.; Pita-Illobre, D.; Li, K. W.; Scheper, W.
10.1101/2025.03.28.645932 — neuroscience — Posted on 2025-06-13
2308 Lung inflammation is associated with lipid deposition
Potashnikova, D. M.; Tvorogova, A. V.; Komissarov, A. A.; Saidova, A. A.; Sotnikova, T. N.; Makarova, V. O.; Arifulin, E. A.; Lipina, T. V.; Shirokova, O. M.; Melnikov, E. S.; Rodina, T. A.; Valyaeva, A. A.; Zharikova, A. A.; Zayratyants, G. O.; Zayratyants, O. V.; Sheval, E. V.; Margolis, L. B.; Vasilieva, E. Y.
10.1101/2022.12.30.522299 — pathology — Posted on 2025-06-13
2313 Chiari II brain malformation is secondary to open spina bifida
Clark, M.; Edwards, T. J.; Savery, D.; Galea, G. L.; Samy, N.; Pauws, E.; Kessaris, N.; Greene, N. D.; Copp, A. J.
10.1101/2025.01.06.631442 — developmental biology — Posted on 2025-06-13
2314 The systemic anti-diabetic effect of polyherbal formulation Varanadi Kashayam is mediated through GLP-1 secretion and DPP4 inhibition
Thottappillil, A.; Kouser, S.; Badiger, A. V.; Pinto, P. G.; Ramachandran, S.; Janadri, S.; Mudagal, M. P.; Kukkupuni, S. K.; Mohan S, S.; Chethala N, V.
10.1101/2024.06.29.601306 — cell biology — Posted on 2025-06-13
2315 A new nitrogen biochemical process: Oxidization of ammonium into nitrogen gas using nitrate
lv, x.; zhang, s.; gu, p.; han, x.; li, q.; huang, j.; qu, z.; zhao, d.; wang, z.; li, k.; wang, c.
10.1101/2025.06.12.659240 — microbiology — Posted on 2025-06-13
2316 Age-dependent gut microbiota dynamics and their association with male fitness traits in Drosophila melanogaster
Sultanova, Z.; Dönertas, H. M.; Hita, A.; Aguilar, P.; Dag, B.; Lucas-Lledo, J. I.; Latorre, A.; Carazo, P.
10.1101/2025.05.22.655607 — microbiology — Posted on 2025-06-13
2320 Distinct heterozygous TTC7A missense variants lead to different intestinal epithelial phenotypes in pediatric IBD
Jeshvaghani, Z. S.; Deenichina, P.; Collen, L.; de Vries, M.; Brunsveld, J.; Kotlarz, D.; Koletzko, S.; Klein, C.; Beekman, J.; Snapper, S.; Lindemans, C.; Mokry, M.; Argmann, C.; Kuijk, E.; Nieuwenhuis, E.
10.1101/2025.06.11.659065 — genetics — Posted on 2025-06-13
2321 Shouldering the challenge of deciphering avian palate evolution
Benito, J.; Kuo, P.-C.; Torres, C. R.; Navalon, G.; Plateau, O.; Clark, A. D.; Steell, E. M.; Field, D. J.
10.1101/2025.06.10.658509 — evolutionary biology — Posted on 2025-06-13
2322 Deciphering the microbial landscape of lower respiratory tract in health and respiratory diseases
Cheng, C.; Li, Y.; Wang, S.; Wang, H.; Liu, D.; Wang, Q.; Che, Y.; Xue, L.; Chao, N.; He, X.; Li, C.; Tian, H.; Zhou, J.; Wang, X.; Yang, Y.; Zhu, Y.; Xu, R.; Wang, Z.; Li, W.
10.1101/2025.06.11.659233 — microbiology — Posted on 2025-06-13
2323 The Art of Not Knowing: Accommodating Structured Missingness in Biomedical Research
Rehak Buckova, B.; Fraza, C.; Koldbaek, C.; Barthel Flaaten, C.; Sofie Saether, L.; Cattarinussi, G.; Sando Ambrosen, K. M.; Andreassen, O. A.; Westlye, L. T.; Beckmann, C.; Ebdrup, B.; Dazzan, P.; Ueland, T.; Mitra, R.; Marquand, A.
10.1101/2025.06.07.658014 — neuroscience — Posted on 2025-06-13
2324 Multiplex Proteomics of Lewy Body Dementia Reveals Cerebrospinal Fluid Biomarkers of Disease Pathology and Progression
Higginbotham, L.; Shantaraman, A.; Guo, Q.; Fox, E. J.; Bagchi, P.; Wu, F.; Lah, J. J.; Levey, A. I.; Seyfried, N. T.
10.1101/2025.06.10.658994 — systems biology — Posted on 2025-06-13
2327 EFFECTS OF ATTACHMENT DESIGNS ON CLEAR ALIGNER TOOTH MOVEMENT: A FINITE ELEMENT ANALYSIS
Mamboleo, E.; Ouldyerou, A.; Alsharif, K.; Ngan, P.; Guan, G.; Merdji, A.; Mukdadi, O.; Egon Mamboleo, Abdelhak Ouldyerou, Khaled Alsharif, Peter Ngan, Guoqiang Guan, Ali Merdji, and Osama,
10.1101/2025.06.11.659198 — bioengineering — Posted on 2025-06-13
2334 Predicting protein stability changes upon mutations with dual-view ensemble learning from single sequence
Nie, Z.; Ma, Y.; Liu, Y.; Huang, X.; Liu, Z.; Yang, P.; Xu, F.; Yin, F.; Li, Z.; Fu, J.; Ren, Z.; Zhang, W.-B.; Chen, J.
10.1101/2024.04.22.590665 — bioinformatics — Posted on 2025-06-13
2336 Human Peripheral Nerve-on-a-Chip on a Multiwell Microelectrode Array as a Scalable Preclinical Neurotoxicity Assay
Rountree, C.; Rodriguez, T.; Byrne, E.; Schmidt, E.; Schwarzbach, E.; Dillon, S.; McCrimmon, A.; Terral, M.; Metea, M.; Moore, M. J.; Curley, J. L.
10.1101/2025.06.09.658615 — pharmacology and toxicology — Posted on 2025-06-12
2338 Contextual modulation and blunted defensive responses to predators in head-fixed and freely moving mice
Ritter, M.; Barreira, L. M. C.; Sach, L.; Hakus, A.; Oektem, S. K.; Bergmann, R.; Voigt, A.; Schmitz, D.; Poirazi, P.; Larkum, M. E.; Sachdev, R.
10.1101/2025.06.09.658679 — animal behavior and cognition — Posted on 2025-06-12
2339 A survey of dietary effects on tRNA abundance and modifications
Liu, S.; Holmes, A. D.; Zhao, R.; Herbert, C.; Limbach, P. A.; Lowe, T. M.; Sharma, U.
10.1101/2025.06.10.658430 — genomics — Posted on 2025-06-12
2340 Direct RNA nanopore sequencing reveals rapid RNA modification changes following glucose stimulation of human pancreatic beta-cell lines
Mulroney, L.; Taylor, H. J.; Lee, A.; Swift, A. J.; Zdravkov, M.; Bonnycastle, L. L.; Brooks, S. Y.; Lee, B. N.; Fitzgerald, T.; Narisu, N.; Biesecker, L. G.; Erdos, M. R.; Nicassio, F.; Birney, E.; Collins, F. S.; Taylor, D. L.
10.1101/2025.06.12.659352 — genomics — Posted on 2025-06-12
2341 Phage-Assisted Evolution of Allosteric Protein Switches
Southern, N. T.; von Bachmann, A.-L.; Hovsepyan, A.; Griebl, M.-L.; Wolf, B.; Lemmen, N.; Kroell, A.-S.; Westermann, S.; Mathony, J.; Niopek, D.
10.1101/2025.06.12.659331 — synthetic biology — Posted on 2025-06-12
2343 Accounting for differences between Infinium MethylationEPIC v2 and v1 in DNA methylation-based tools
Zhuang, B. C.; Jude, M. S.; Konwar, C.; Yusupov, N.; Ryan, C. P.; Engelbrecht, H.-R.; Whitehead, J.; Halberstam, A. A.; MacIsaac, J. L.; Dever, K.; Tran, T. K.; Korinek, K.; Zimmer, Z.; Lee, N. R.; McDade, T. W.; Kuzawa, C. W.; Huffman, K. M.; Belsky, D. W.; Binder, E. B.; Czamara, D.; Korthauer, K.; Kobor, M. S.
10.1101/2024.07.02.600461 — genomics — Posted on 2025-06-12
2344 Methanobrevibacter smithii associates with colorectal cancer through trophic control of the cancer bacteriome
Mohammadzadeh, R.; Mahnert, A.; Zurabischvili, T.; Wink, L.; Kumpitsch, C.; Habisch, H.; Sprengel, J.; Filek, K.; Mertelj, P.; Pernitsch, D.; Hingerl, K.; Gorkiewicz, G.; Diener, C.; Loy, A.; Kolb, D.; Trautwein, C.; Madl, T.; Moissl-Eichinger, C.
10.1101/2025.06.12.659283 — microbiology — Posted on 2025-06-12
2345 Planetary-scale metagenomic search reveals new patterns of CRISPR targeting
Roux, S.; Neri, U.; Bushnell, B.; Fremin, B.; George, N.; Gophna, U.; Hug, L. A.; Camargo, A. P.; Wu, D.; Ivanova, N.; Kyrpides, N. C.; Eloe-Fadrosh, E. A.
10.1101/2025.06.12.659409 — microbiology — Posted on 2025-06-12
2346 Prophage regulation of Shewanella fidelis 3313 motility and biofilm formation: implications for gut colonization dynamics in Ciona robusta
Natarajan, O.; Gibboney, S. L.; Young, M. N.; Lim, S. J.; Nguyen, F.; Pluta, N.; Atkinson, C. G. F.; Leigh, B. A.; Liberti, A.; Kees, E. D.; Breitbart, M.; Gralnick, J. A.; Dishaw, L. J.
10.1101/2022.11.23.517592 — microbiology — Posted on 2025-06-12
2347 Assessing the Sylvatic Yellow Fever Vectors in Southern Brazil
Cardoso, S. F.; Kikuti, L. A. O.; Yoshikawa, A. A. G.; Pinheiro, I. C.; Guesser, J. V. C.; Neves, M. S. A. S.; Couto-Lima, D.; Gatti, R. R.; Prophiro, J. S.; Pitaluga, A. N.; Rona, L. D. P.
10.1101/2025.06.12.659296 — microbiology — Posted on 2025-06-12
2348 Pandemic Vibrio parahaemolyticus wave succession by gene loss
Yang, C.; Qiu, H.; Svensson, S. L.; Ni, C.; Gao, S.; Jia, Z.; Wen, H.; Xie, L.; Xu, W.; Qin, Y.; Lin, S.; Wang, J.; Zhang, Y.; Li, Y.; Jiang, M.; Shi, X.; Hu, Q.; Zhou, Z.; Chao, Y.; Yang, R.; Cui, Y.; Martinez-Urtaza, J.; Wang, H.; Falush, D.
10.1101/2024.06.03.596356 — microbiology — Posted on 2025-06-12
2349 A single MHCII neoepitope mRNA vaccine elicits CD4 T- and B- cell responses promoting endogenous CD8 anti-tumor immunity
Capietto, A.-H.; Balanca, C.-C.; Bouziat, R.; Wu, T.; Gober, J.; Carbone, C.; Nissenbaum, A.; Hoshyar, R.; Yadav, M.; Gutierrez, A.; Chestnut, Y.; Javinal, V.; Menon, H.; Darmanis, S.; de Simone, M.; Sun, Y.; Seshasayee, D.; Paluch, M.; Bulutoglu, B.; Jones, T.; Wang, Y.; Liao, L.; Duong, E.; Anand, A.; Antonelli, A.; Oei, Y.; Cheung, J.; Luoh, S.-M.; Ziai, J.; Preston, J.; Hung, J.; Freund, E.; Wichner, S.; Oh, J.; Tahtinen, S.; Sahin, U.; ElSohly, A.; Schartner, J.; Delamarre, L.; Mellman, I.; Linehan, J.
10.1101/2025.06.09.657934 — immunology — Posted on 2025-06-12
2351 GABA-independent activation of GABAB receptor by mechanical forces
Hu, Y.; Zhou, Y.; Lin, L.; Yang, F.; He, F.; Zhang, F.; Song, M.; Shen, C.; Liu, Y.; Xu, C.; Xu, S.; Liu, J.
10.1101/2025.06.09.658551 — neuroscience — Posted on 2025-06-12
2352 Striatal output regulates the postnatal maturation of cortical circuits
Janecek, M.; Deemyad, T.; Shih, Y.-C.; Valle, V.; D'Agostino, A.; Matarazzo, M.; Perez, M.; Ketchesin, K.; Silva, S.; Peixoto, R.
10.1101/2024.05.10.593512 — neuroscience — Posted on 2025-06-12
2357 Lrrc14b is a novel regulator of striated muscle function
Akinborewa, O.; Prabakaran, A. D.; Durumutla, H. B.; Latimer, H.; McFarland, K.; Quattrocelli, M.
10.1101/2025.06.09.658659 — physiology — Posted on 2025-06-12
2358 The metabolic and molecular mechanisms underlying running-induced energy compensation
Sanchis, P.; Baech-laursen, C.; Vizueta, J.; Haytural, H.; Kurgan, N.; Persson, K. W.; Groenning, A.; Salinas, R.; Samodova-Sommer, D.; Guo, J.; Jensen, T. E.; Deshmukh, A. S.; Pedersen, B. K.; Brandt, C.
10.1101/2025.06.09.658628 — physiology — Posted on 2025-06-12
2365 M. tuberculosis meets European Lead Factory - identification and structural characterization of novel Rv0183 inhibitors using X-ray crystallography
Riegler-Berket, L.; Goedl, L.; Polidori, N.; Aschauer, P.; Grininger, C.; Prosser, G.; Lichtenegger, J.; Sagmeister, T.; Parigger, L.; Gruber, C. C.; Reiling, N.; Oberer, M.
10.1101/2025.06.12.659322 — biochemistry — Posted on 2025-06-12
2369 WAVE complex forms linear arrays at negative membrane curvature to instruct lamellipodia formation.
Wu, M.; Sadhu, R. K.; Meyer, K.; Tang, Z.; Marchando, P.; Woolfson, D. N.; Gov, N. S.; Weiner, O. D.
10.1101/2024.07.08.600855 — cell biology — Posted on 2025-06-12
2370 Age-Related Patterns of DNA Methylation Changes
Chen, K. Y.; Wang, W.; Suryadevara, H. N. S. K.; Peng, G.
10.1101/2024.12.10.627727 — molecular biology — Posted on 2025-06-12
2371 Structural Basis for Cas9-Directed Spacer Acquisition in Type II-A CRISPR-Cas Systems
Li, Z.; Li, Y.; Kong, J.; Wu, Q.; Huang, P.; Zhang, Y.; Wu, W.; Chen, M.; Liu, Y.; Lin, H.; Hou, L.; Liu, G.; Zeng, T.; He, Y.; Hu, C.; Yang, Z.; Lu, M.; Min, L.; Xiao, Y.
10.1101/2025.06.12.659315 — molecular biology — Posted on 2025-06-12
2372 Ralstonia pseudosolanacearum LOV domain protein regulates environmental stress tolerance, iron homeostasis, and bacterial wilt virulence
O'Banion, B.; Carter, M. D.; Sanchez-Gallego, J. A.; Li, H.; Hayes, S. S.; Strysick, M.; Holcomb, J.; Allen, C.
10.1101/2025.06.11.659228 — microbiology — Posted on 2025-06-12
2374 Chenodeoxycholic Acid Modulation via Bacteroides intestinalis AM1 underscores a Novel Approach in Acute Liver Failure
PANDEY, S.; Sharma, N.; Sharma, N.; Bhat, S. H.; Sharma, V.; Kushwaha, M.; Kumar, A.; Magar, Y.; Gupta, A.; Mathew, B.; Tripathi, G.; Bindal, V.; Yadav, S.; Yadav, M.; Parasar, A.; Sharma, S.; Bihari, C.; Katyal, A.; Maiwall, R.; Sarin, S. K.; Maras, J. S.
10.1101/2025.06.11.659225 — microbiology — Posted on 2025-06-12
2375 Bacterial species and surface structures shape gene transfer and the transcriptional landscape during early conjugation
Williams, G. C.; Danne, J. C.; Crawford, S.; Homman-Ludiye, J.; Kostoulias, X.; Islam, T.; Heron, B.; Yong, M.; Gan, Y.-H.; Srikhanta, Y.; Lyras, D.
10.1101/2025.06.12.659224 — microbiology — Posted on 2025-06-12
2377 Full inter-hemispheric integration sustained by a fraction of posterior callosal fibers
Santander, T.; Bekir, S.; Paul, T.; Simonson, J. M.; Wiemer, V. M.; Skinner, H. E.; Hopf, J. L.; Rada, A.; Woermann, F. G.; Kalbhenn, T.; Giesbrecht, B.; Bien, C. G.; Sporns, O.; Gazzaniga, M. S.; Volz, L. J.; Miller, M. B.
10.1101/2025.02.14.638327 — neuroscience — Posted on 2025-06-12
2378 Hyperpolarization-activated cation channel mediated intrinsic plasticity changes underlie the malleability of with-in cell-type electrophysiological heterogeneity
Chameh, H. M.; Falby, M.; Yang, Y.; Movahed, M.; Arbabi, K.; Sarathy, C.; Tripathy, S. J.; Zhang, L.; Lefebvre, J.; Valiante, T. A.
10.1101/2025.06.09.658517 — neuroscience — Posted on 2025-06-12
2379 Human brain cell types shape host-rabies virus transcriptional interactions revealing a preexisting pro-viral astrocyte subpopulation
Feige, L.; Young, K.; Cerapio, J. P.; Kozaki, T.; Kergoat, L.; Libri, V.; Ginhoux, F.; Hasan, M.; Ben Ameur, L.; Chin, G.; Goode, Z.; Bourhy, H.; Saunders, A.
10.1101/2024.12.18.629263 — neuroscience — Posted on 2025-06-12
2381 A fast TMT-based proteomic workflow reveals neural enrichment in neurospheres of hiPSC-derived neural stem cells
Muniz, P. d. L.; Souza, L. R. Q.; Martins, M. R.; Valadares, W.; Nogueira, F. C. S.; Rehen, S.; Nugue, G.; Junqueira, M.
10.1101/2025.06.09.658417 — bioinformatics — Posted on 2025-06-12
2382 Structural insights into Cas9-mediated prespacer selection in CRISPR-Cas adaptation
Gaizauskaite, U.; Tamulaitiene, G.; Silanskas, A.; Gasiunas, G.; Siksnys, V.; Sasnauskas, G.
10.1101/2025.06.12.659244 — microbiology — Posted on 2025-06-12
2383 A new nitrogen biochemical process: Oxidization of ammonium into nitrogen gas using nitrate
lv, x.; zhang, s.; gu, p.; han, x.; li, q.; huang, j.; qu, z.; zhao, d.; wang, z.; li, k.; wang, c.
10.1101/2025.06.12.659240 — microbiology — Posted on 2025-06-12
2384 Stereotypy is strongly linked to multiple biomarkers of oxidative stress--a potential common etiology for Abnormal Repetitive Behaviors
Coden, K. M.; Beacham, K.; Stix-Brunell, B.; Moorhead, R.; Byrd, K.; Baker, J.; Geronimo, J.; Parker, K. J.; Garner, J. P.
10.1101/2025.06.09.658735 — animal behavior and cognition — Posted on 2025-06-12
2386 Species-specific oculomotor control tolerances predict saccadic suppression strength in macaques and zebrafish
Soto, G.; Dehmelt, F. A.; Baumann, M. P.; Tunc, I.; Yu, Y.; Malevich, T.; Hafed, Z. M.; Arrenberg, A. B.
10.1101/2025.06.09.658731 — neuroscience — Posted on 2025-06-12
2387 Organellar data sets confirm overall angiosperm relationships if problematic RNA-edit sites are accounted for in mitochondrial genomes
Gerelle, W. K.; Jost, M.; Marques, I.; Les, D.; Vallejos, R.; Little, S.; Sinn, B. T.; Sokoloff, D. D.; Macfarlane, T. D.; Iles, W.; Feild, T.; Mathews, S.; Moore, M.; Couvreur, T. L. P.; Sauquet, H.; Wanke, S.; Graham, S. W.
10.1101/2025.06.09.658674 — plant biology — Posted on 2025-06-12
2388 Anti-isoDGR Antibody Inhibits Atherosclerosis Induced by Western Diet in ApoE-/- mice
Kalailingam, P.; Ngan, S. C.; Gallart-Palau, X.; Serra, A.; Datta, A.; Ch'ng, T. H.; Tsiani, E. L.; Klentrou, P.; Kalaria, R. N.; McCarthy, N. E.; De Kleijn, D.; Sze, S. K.
10.1101/2025.06.09.658749 — pharmacology and toxicology — Posted on 2025-06-12
2390 Autocrine TGFβ2 enforces a transcriptionally hybrid cell state in Ewing sarcoma
Wrenn, E. D.; Harris, J. C.; Apfelbaum, A.; Valenti, J. R.; Lipson, P. A.; Walter, S. I.; Garcia, N. M.; Miyaki, A.; Chen, S. C.; Olson, J. M.; Price, J. S.; Bailey, K. M.; Lawlor, E. R.
10.1101/2025.06.11.653876 — cancer biology — Posted on 2025-06-12
2400 A Thiopurine-like Mutagenic Process Defines TGCT Subtypes
Brown, K. M.; Zhong, J.; Miranda, A. M.; Zhang, M.; Williams, J.; Williams, J.; Zhang, H.; Liang, C.; Li, W.; Zhu, B.; Chanock, S. J.; Nathanson, K. L.; Zhang, T.
10.1101/2025.06.12.655573 — genomics — Posted on 2025-06-12
2401 Unbiased recording of clonal potency reveals species-specific regulation of mammalian intestine
Islam, M.; Bechard, M. E.; Yang, Y.; Simmons, A. J.; Xu, Y.; Higginbotham, J. N.; Zhao, P.; Cao, Z.; Tasneem, N.; Glass, S. E.; Markham, N. O.; Revetta, F.; Ramirez-Solano, M. A.; Liu, Q.; Franklin, J. L.; Lau, K.; Coffey, R. J.
10.1101/2025.06.10.658707 — genomics — Posted on 2025-06-12
2403 Juvenile hormone degradation enzymes have shared and unique requirements in Drosophila development
Siegel, H.; Healy, C.; Goyins, K.; Jumamyradova, A.; Ying, J.; Soshnev, A. A.; Spokony, R. F.; Barton, L. J.
10.1101/2025.06.09.657647 — genetics — Posted on 2025-06-12
2406 Population genomics of incipient allochronic divergence in the Pine Processionary Moth
Muller, T.; Gautier, M.; Lombaert, E.; Leblois, R.; Saune, L.; Branco, M.; Kerdelhue, C.; Perrier, C.
10.1101/2025.06.09.657100 — evolutionary biology — Posted on 2025-06-12
2408 Spatial Biodiversity Indicators and a Composite Index for Conservation Prioritization in Switzerland
Adde, A.; Boussange, V.; Chauvier, Y.; Dahito, M.-A.; Fruh, J.; Gross, A.; Stofer, S.; Rey, E.; Sieber, P.; Fopp, F.; Schouten, R.; Van Moorter, B.; Guisan, A.; Graham, C.; Pellissier, L.; Zimmermann, N. E.; Altermatt, F.
10.1101/2025.06.10.657334 — ecology — Posted on 2025-06-12
2411 A single-cell fixed RNA profiling of liver fibrosis progression and regression reveals SEMA4D and LMCD1 as key mediators of fibrogenesis
Pham, D. M.; Thuy, L. T. T.; Hoang, H.; Nguyen, H. T.; Pham, A. T.; Ikenaga, H.; Fuji, H.; Yuasa, H.; Matsubara, T.; Vu, H. T.; Yi, C.; Yamagishi, R.; Ohtani, N.; Oikawa, D.; Tokunaga, F.; Kisseleva, T.; Brenner, D.; Iwakiri, Y.; Sancho, J. G.; Kawada, N.
10.1101/2025.06.12.657772 — cell biology — Posted on 2025-06-12
2414 Shaping a Collaborative, Sustainable, Accessible, and Reproducible Future for Computational Modeling
Guidon, M.; Kaiser, D.; Iavarone, E.; Anderegg, S.; Bisgaard, M.; Bujard, C.; Cassara, A.; Crespo-Valero, P.; Drobuliak, M.; Fasse, A.; Hrytsuk, Y.; Karimi, F.; Maiz, O.; Neagu, A.; Newton, T.; Ordonez, J.; Oetiker, T.; Pascual, I.; Querido, J.; Regel, S.; Steiner, M.; Van Geit, W.; Zhuang, K.; Weitz, A.; Chavannes, N.; Kuster, N.; Neufeld, E.
10.1101/2025.06.12.656959 — neuroscience — Posted on 2025-06-12
2416 Oncogenic and tumor-suppressive forces converge on a progenitor-orchestrated niche to shape early tumorigenesis
Reyes, J.; Del Priore, I.; Chaikovsky, A. C.; Pasnuri, N.; Elhossiny, A. M.; Krause, T.; Moorman, A.; Snopkowski, C.; Takizawa, M.; Burdziak, C.; Ratnayeke, N.; Masillioni, I.; Ho, Y.-J.; Chaligne, R.; Romesser, P. B.; Filliol, A.; Nawy, T.; Morris, J. P.; Zhao, Z.; Di Magliano, M. P.; Alonso-Curbelo, D.; Pe'er, D.; Lowe, S. W.
10.1101/2025.06.10.656791 — cancer biology — Posted on 2025-06-12
2418 Advancing Fair and Explainable Machine Learning for Neuroimaging Dementia Pattern Classification in Multi-Ethnic Populations
Ho, N.-H.; Charisis, S.; Honnorat, N.; Brandigampala, S. R.; Wang, D.; Heckbert, S. R.; Fox, P. T.; Martinez, D.; Wang, D. H.; Hughes, T. M.; Archer, D. B.; Hohman, T. J.; Seshadri, S.; Davatzikos, C.; Habes, M.
10.1101/2025.06.09.658375 — neuroscience — Posted on 2025-06-12
2419 DR5 CAR-T cells target solid tumors and suppress MDSCs with minimal toxicity
Wang, H.; Liu, S.; Sinha, P.; Liu, F.; Zhang, X.; Guo, Y.; Goncalves, B.; Zheng, Q.; Mou, H.; Yang, J.; Huang, L.; Scholler, J.; Miao, F.; Zeng, T.; Karakousis, G.; Huang, A. C.; Mitchell, T.; Amaravadi, R.; Schuchter, L.; Milone, M.; Guo, W.; June, C. H.; Herlyn, M.; Fan, Y.; Xu, X.
10.1101/2025.06.09.658618 — cancer biology — Posted on 2025-06-12
2423 Single-nucleus analysis reveals oxidative stress in Down syndrome basal forebrain neurons at birth
West, N. R.; Arachchilage, K. H.; Knaack, S.; MacGregor, S.; Hosseini, M.; Risgaard, R. D.; Kumarage, P.; Martinez, J. L.; Zhang, S.-C.; Wang, D.; Sousa, A. M. M.; Bhattacharyya, A.
10.1101/2025.02.05.636750 — neuroscience — Posted on 2025-06-12
2424 Alterations of the composition and spatial organization of the microenvironment following non-dysplastic Barrett's esophagus through progression to cancer
Lin, M.-L.; Hickey, J. W.; Passman, A.; Carlotti, E.; Devkumar, S.; Derwa, Y. H.; ChinAleong, J.; Hackett, R. J.; Evans, J. A.; Sangwan, V.; Novelli, M. R.; Rodriguez-Justo, M.; Wright, N. A.; Jansen, M.; Underwood, T. J.; Huang, S.; Gascard, P.; McLean, M. H.; Schurch, C. M.; Tlsty, T. M.; Ferri, L.; Nolan, G. P.; McDonald, S. A.
10.1101/2025.06.09.657642 — cancer biology — Posted on 2025-06-12
2429 A critical role of sux cistron-mediated sucrose uptake for virulence of the rice blight pathogen Xanthomonas oryzae pv. oryzae
Zoellner, N.; Long, J. Y.; Song, C.; Sharkey, J.; Wudick, M. M.; Loo, E. P.; Sadoine, M.; Applegate, V.; Port, A.; Smits, S.; Yang, B.; Frommer, W. B.
10.1101/2025.06.02.657373 — microbiology — Posted on 2025-06-12
2430 Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds.
Meunier, D.; Corona-Torres, R.; Boulton, K.; Wu, Z.; Ballantyne, M.; Glendinning, L.; Ahmad, A. A.; Borowska, D.; Taylor, L.; Vervelde, L.; del Pozo, J.; Vasilogianni, M.; Jaramillo-Ortiz, J.; Sanchez-Arsuaga, G.; Psifidi, A.; Tomley, F.; Watson, K. A.; McGrew, M. J.; Stevens, M. P.; Blake, D. P.; Hume, D. A.
10.1101/2025.01.10.632125 — immunology — Posted on 2025-06-12
2432 Male and female mice may respectively form stronger social aversive memories with same and different sex conspecifics
Beaver, J. N.; Nicodemus, M. M.; Spalding, I. R.; Scrimshaw, L. R.; Dutta, S.; Jasnow, A. M.; Gilman, L. M.
10.1101/2024.08.12.607663 — neuroscience — Posted on 2025-06-12
2434 ASXL1 truncating mutations drive leukemic resistance to T cell attack
McCurry, D. B.; Ge, Z.; Lee, J.; Pasumarthi, R.; Leng, X.; Koehnke, T.; Pasvolsky, O.; Raparla, P.; Nguyen, V.; Maurer, K.; Li, S.; Livak, K. J.; Danson, E.; Thakkar, B.; Azizi, E.; Soiffer, R. J.; Shukla, S. A.; Majeti, R.; Ritz, J.; Wu, C. J.; Molldrem, J. J.; Bachireddy, P.
10.1101/2025.05.29.656798 — cancer biology — Posted on 2025-06-12
2435 Targeting SCD in SCD-amplified prostate cancer inhibits growth in bone by modulating cellular stress, mTOR, and DNA damage pathways
Wilson, A.; Herroon, M. K.; Mecca, S.; Garmo, L.; Lindquist, J.; Rajendran, S.; Patrick, S. M.; PODGORSKI, I.
10.1101/2025.06.09.658523 — cancer biology — Posted on 2025-06-12
2438 The complete mitochondrial genome of Tunga penetrans and insights into flea phylogeny
Bartilol, B.; Mburu, M. W.; Owaret, J.; Andisi, C.; Oyier, I.; Muriu, S.; Elson, L.; Maia, M.; Mwangangi, J.; Githinji, G.; Rono, M.
10.1101/2025.06.09.658575 — genomics — Posted on 2025-06-12
2440 Measuring renal cortical cell-specific mitochondrial metabolism
Feola, K.; Venable, A. H.; Rasouli, M.; Do, J.; McCoy, T.; Llamas, C. B.; Straus, D.; Mishra, P.; Najafian, B.; Huen, S.
10.1101/2024.11.24.622516 — molecular biology — Posted on 2025-06-12
2441 Single-cell transcriptomics yield insights into the stress-immune interplay and inform disease risk
Benavides, S.; Kosyk, O.; Carpenter, L.; Georgiou, C.; Miller, B. C.; Stanley, N.; Zannas, A. S.
10.1101/2025.06.05.658150 — immunology — Posted on 2025-06-12
2442 DEVELOPMENT OF A POTENT MONOCLONAL ANTIBODY FOR TREATMENT OF HUMAN METAPNEUMOVIRUS INFECTIONS
Harris, E. D.; McGovern, M.; Pernikoff, S.; Ikeda, R.; Kipnis, L.; Hannon, W.; Sobolik, E. B.; Gray, M.; Greninger, A. L.; He, S.; Chin, C.-N.; Fu, T.-M.; Pancera, M.; Boonyaratanakornkit, J.
10.1101/2025.06.09.657676 — immunology — Posted on 2025-06-12
2444 Reduced susceptibility to experimentally-induced complex visual hallucinations with age
Shenyan, O.; Haye, L.; Milne, G. A.; Lisi, M.; Greenwood, J. A.; Skipper, J. I.; Dekker, T. M.
10.1101/2025.05.27.656359 — neuroscience — Posted on 2025-06-12
2445 FERONIA defines intact tissue boundaries through cuticle development
Kim, G.; Choi, J.; Kim, R. J.; Oh, E.; Shin, S. Y.; Kim, H.-S.; Cho, H. S.; Suh, M. C.; Lee, H.-J.
10.1101/2025.06.09.658546 — plant biology — Posted on 2025-06-12
2446 Alterations of the composition and spatial organization of the microenvironment following non-dysplastic Barrett's esophagus through progression to cancer
Lin, M.-L.; Hickey, J. W.; Passman, A.; Carlotti, E.; Devkumar, S.; Derwa, Y. H.; ChinAleong, J.; Hackett, R. J.; Evans, J. A.; Sangwan, V.; Novelli, M. R.; Rodriguez-Justo, M.; Wright, N. A.; Jansen, M.; Underwood, T. J.; Huang, S.; Gascard, P.; McLean, M. H.; Schurch, C. M.; Tlsty, T. M.; Ferri, L.; Nolan, G. P.; McDonald, S. A.
10.1101/2025.06.09.657642 — cancer biology — Posted on 2025-06-12
2447 SAMP-Score: A morphology-based machine learning classification method for screening pro-senescence compounds in p16 positive cancer cells
Wallis, R.; Hughes, B. K.; Moore, M.; O'Sullivan, E. A.; McIlvenna, L. C.; Gammon, L.; Hope, A.; Bellany, F.; Mackenzie, C.; Green, C.; Gray, D.; Bishop, C. L.
10.1101/2025.06.09.658585 — cancer biology — Posted on 2025-06-12
2451 COX6B1 secures a redox-sensitive step in early cytochrome c oxidase assembly
Cunatova, K.; Vrbacky, M.; Knezu, M.; Pecinova, A.; Alan, L.; Houstek, J.; Fernandez-Vizarra, E.; Mracek, T.; Pecina, P.
10.1101/2025.03.25.645161 — biochemistry — Posted on 2025-06-12
2452 A novel reusable transcriptome-wide association study workflow used to map key genes linked to important cattle traits
Jayaraman, S.; Chitneedi, P. K.; Kadri, N. K.; Costa-Monteiro-Moreira, G.; Salavati, M.; Charlier, C.; Boichard, D.; Sanchez, M.-P.; Pausch, H.; Kuehn, C.; Prendergast, J. G.; Clark, E. L.
10.1101/2025.06.10.658680 — genomics — Posted on 2025-06-12
2453 Evaluating Large Language Models for Gene-to-Phenotype Mapping: The Critical Role of Full-Text Database Access
Suhardi, N. M.; Oktarina, A.; Dhillon, D.; Ninan, D.; Retzky, J.; Bostrom, M.; Yang, X.; Suhardi, V. J.
10.1101/2025.06.11.659165 — genetics — Posted on 2025-06-12
2454 Biological causes and impacts of rugged tree landscapes in phylodynamic inference
Gao, J.; Brusselmans, M.; Carvalho, L. M.; Suchard, M. A.; Baele, G.; Matsen, F. A.
10.1101/2025.06.10.657742 — evolutionary biology — Posted on 2025-06-12
2455 The Green Band: Using Production and Catch to Judge Distortive Pressure on an Ecosystem
Fulton, E. A.; Sainsbury, K.; Bulman, C.; Novaglio, C.; Porobic, J.; Hayes, D.; van Putten, E. I.; Dutra, L. X. C.; Thomas, L.; Norris, W.; Pert, C.; Willock, A.; Montenegro, S. C.; Garay-Narvaez, L.; Hernandez, S.; Hernandez Saso, A.; Mohamed, K. S.; Sathianandan, T. V.; Kuriakose, S.; Varghese, E.; Najmudeen, T. M.; Vasudevan, S.; Anish, M. K. G.; Salim, S.; Mandro, I.; Zador, S.; Ortiz, I.; Whitehouse, A.; Aydin, K.; Tweit, B.; Evans, D.
10.1101/2025.06.09.658403 — ecology — Posted on 2025-06-12
2456 An optimized rabies vaccine vehicle for orotopical administration to wild vampire bats.
Knuese, C.; Cardenas-Canales, E. M.; McDevitt-Galles, T.; Ramirez-Martinez, M. M.; Limonta, D.; Powers, L. E.; Walsh, D. P.; Streicker, D. G.; Osorio, J. E.; Zamanian, M.; Rocke, T. E.
10.1101/2025.06.03.657068 — ecology — Posted on 2025-06-12
2457 Near-infrared spectroscopy-based models correctly classify Abies alba seed origin and predict germination properties
Poughon, J.; Lepoittevin, C.; Vicente, E.; Carme, M.; Mihai, G.; Lario Leza, F.; Piotti, A.; Avanzi, C.; Marchi, M.; Vendramin, G. G.; Scotti-Saintagne, C.; Fady, B.; Teyssier, C.; Benito Garzon, M.
10.1101/2025.06.09.658572 — ecology — Posted on 2025-06-12
2459 Dynamics of cortico-subthalamic neuronal patterns during dyskinesia in Parkinsons disease
Habets, J. G.; Merk, T.; Mathiopoulou, V.; Lofredi, R.; Binns, T. S.; Busch, J. L.; Koehler, R. M.; Memarpouri, A.; Faust, K.; Krause, P.; Schneider, G.-H.; Neumann, W.-J.; Tovote, P.; Kuehn, A. A.
10.1101/2025.06.09.658641 — neuroscience — Posted on 2025-06-12
2460 Ablation of hepatocyte derived-FGL1 does not aggravate metabolic dysfunction-associated steatotic liver disease and hepatocellular carcinoma
Personnaz, J.; Cannizzo, L.; Martin, C. M. P.; Desquesnes, A.; Sotin, M.; DaSilva, J.; Perrier, P.; Guillou, H.; Kautz, L.
10.1101/2024.12.23.628701 — pathology — Posted on 2025-06-12
2461 Early postnatal resting-state structural-functional coupling in the perisylvian region
Namiranian, R.; Abrishami Moghaddam, H.; Khadem, A.; Jafari, R.; Chalechale, A.
10.1101/2023.10.26.564007 — bioengineering — Posted on 2025-06-12
2462 Personalized models of Disorders of Consciousness revealcomplementary roles of connectivity and local parameters in diagnosis and prognosis
Zonca, L.; Escrichs, A.; Patow, G. A.; Manasova, D.; Sanz Perl, Y.; Annen, J.; Gosseries, O.; Laureys, S.; Sitt, J.; Deco, G.
10.1101/2024.09.03.610819 — neuroscience — Posted on 2025-06-12
2465 Heightened subcortical reactivity to uncertain-threat is associated with future internalizing symptoms, conditional on stress exposure
Grogans, S. E.; DeYoung, K. A.; Hur, J.; Anderson, A. S.; Islam, S.; Kim, H. C.; Wedlock, J.; Craig, L. E.; Tillman, R. M.; Das, S.; Kuhn, M.; Conway, C. C.; Fox, A. F.; Smith, J. F.; Shackman, A. J.
10.1101/2025.06.11.659182 — neuroscience — Posted on 2025-06-12
2466 Therapeutic splice modulation of COL4A5 reinstates collagen IV assembly in an organoid model of X-linked Alport syndrome
Saei, H.; Estebe, B.; Goudin, N.; Esmailpour, M.; Haure, J.; Gribouval, O.; Arrondel, C.; Moriniere, V.; Tian, P.; Lennon, R.; Antignac, C.; Mollet, G.; Dorval, G.
10.1101/2025.06.10.658776 — genetics — Posted on 2025-06-12
2467 Integration of Audiovisual Motion in Dorsolateral Prefrontal Cortical Neurons
Karimi, A.; Mozumder, R.; Schoenhaut, A.; Rausis, O.; Wallace, M.; Ramachandran, R.; Constantinidis, C.
10.1101/2025.06.11.656227 — neuroscience — Posted on 2025-06-12
2469 Valuing conservation and natural wealth: The blue economy of manta ray watching in the Maldives
Moloney, H. M.; Rojas, M. I. G.; Rothe, N.; Armstrong, A. O.; Ballard, K.; Barraud, F.; Hamdan, F.; Richardson, A. J.; Mohamed Riyad, E.; Sawers, T. J.; Townsend, K. A.; Stevens, G. M. W.
10.1101/2025.06.05.658185 — ecology — Posted on 2025-06-12
2471 The unique molecular recognition features of Siglec-10: structural insights into sialoglycan and antibody interactions
Sobczak, K.; Antonana-Vildosola, A.; Valverde, P.; Travecedo, M. A.; Jame-Chernaboo, Z.; Schmidt, E. N.; DAndrea, S.; Valdaliso-Diez, E.; Oyenarte, I.; Laugieri, M. E.; Joe, M.; Mozaneh, F.; Lin, S.-Y.; Bosch, A.; Moure, M. J.; Franconetti, A.; Lee, S. Y.; Etxaniz-Diaz de Durana, J.; Perez-Gutierrez, L.; Palazon, A.; Marcelo, F.; Fadda, E.; Corzana, F.; Gimeno, A.; Macauley, M. S.; Jimenez-Barbero, J.; Ereno-Orbea, J.
10.1101/2025.06.10.658867 — molecular biology — Posted on 2025-06-12
2472 A SHERLOCK toolbox for eco-epidemiological surveillance of African trypanosomes in domestic pigs from Western Africa.
Eloiflin, R.-J.; Perez-Anton, E.; Camara, A.; Dujeancourt-Henry, A.; Boiro, S.; N Djetchi, M.; Traore, M.; Koffi, M.; Kaba, D.; Le Pennec, Y.; Doukoure, B.; Camara, A. D.; Kagbadouno, M.; Campagne, P.; Camara, M.; Jamonneau, V.; Thevenon, S.; Bart, J.-M.; Glover, L.; Rotureau, B.
10.1101/2025.03.14.643090 — microbiology — Posted on 2025-06-12
2473 MitoTracker transfers from astrocytes to neurons independently of mitochondria
Hole, K. L.; Norkett, R.; Russell, E.; Strom, M.; Howden, J. H.; Corbett, N. J.; Brownlees, J.; Devine, M. J.
10.1101/2025.05.27.655523 — neuroscience — Posted on 2025-06-12
2474 Shared and Distinct Lipid Profiles in amygdala from Sporadic and GBA-associated Parkinson's Diseases
Munoz, S. S.; Marlet, F. R.; Dreier, J. E.; Bilgin, M.; Schott, K.; Neergaard, K. B. S.; Bezard, E.; DEHAY, B.; Jaunmuktane, Z.; Maeda, K.; Galvagnion, C.
10.1101/2024.10.11.617800 — neuroscience — Posted on 2025-06-12
2476 Local and distributed information coding in the ventral stream
Bogdan, P. C.; Howard, C.; Gillette, K.; Cabeza, R.; Davis, S. W.
10.1101/2025.03.09.642235 — neuroscience — Posted on 2025-06-12
2481 ATF4 activates a transcriptional program that chronically suppresses mTOR activity promoting neurodegeneration in Parkinson's disease models
Demmings, M. D.; Kane, E.; Tennyson, E.; Hurley, K.; Zhao, J.; Cruickshanks, N.; Ciz, V.; Krupa, J.; Pasternak, S.; Cregan, S.
10.1101/2025.06.09.658667 — neuroscience — Posted on 2025-06-12
2482 Pervanadate-induced oxidation relieves autoinhibition of SRC protein tyrosine kinase
Mulholland, K. E.; Bourguet, M.; Cheng, N.; Rahman, O.; Ezerina, D.; Daly, L. A.; Lai, T.; Casanova, S. A.; Creixell, P.; Eyers, C.; Eyers, P.; Messens, J.; Byrne, D.; Sharpe, H.
10.1101/2025.04.27.650842 — molecular biology — Posted on 2025-06-12
2484 PDCD1 expression increases at elevated temperatures.
Toma-Jonik, A.; Janus, P.; Mrowiec, K.; Vydra, N.; Sarkowicz, K.; Bar, M.; Mirek, J.; Olbryt, M.; Fidyk, W.; Widlak, W.
10.1101/2025.05.22.652424 — immunology — Posted on 2025-06-12
2487 Why is there so much variability in crop multi-model studies?
Wallach, D.; Palosuo, T.; Mielenz, H.; Buis, S.; Thorburn, P.; Asseng, S.; Dumont, B.; Ferrise, R.; Gayler, S.; Ghahramani, A.; Harrison, M. T.; Hochman, Z.; Hoogenboom, G.; Huang, M.; Jing, Q.; Justes, E.; Kersebaum, K. C.; Launay, M.; Lewan, E.; Liu, K.; Luo, Q.; Mequanint, F.; Nendel, C.; Padovan, G.; Olesen, J. E.; Pullens, J. W. M.; Qian, B.; Seserman, D.-M.; Shelia, V.; Souissi, A.; Specka, X.; Wang, J.; Weber, T. K. D.; Weihermuller, L.; Seidel, S.
10.1101/2023.02.03.526931 — plant biology — Posted on 2025-06-12
2489 In Vitro Characterization of Extracellular Vesicles from the Medicinal Plant Centella asiatica for Aesthetic Applications
Chang, T.-M.; Wu, C.-C.; Huang, H.-C.; Wang, S.-S.; Chuang, C.-H.; Kao, P.-L.; Tang, W.-H.; Liu, L. T.-C.; Qiu, W.-Y.; Percec, I.; Chen, C.; Kuo, T.-Y.
10.1101/2024.12.03.624435 — pharmacology and toxicology — Posted on 2025-06-12
2494 Social Context Restructures Behavioral Syntax in Mice
Ritter, M.; Shipley, H.; Deiana, S.; Hengerer, B.; Wotjak, C. T.; Brecht, M.; Bogadhi, A. R.
10.1101/2025.04.17.648924 — animal behavior and cognition — Posted on 2025-06-12
2495 The gene regulatory landscape driving mouse gonadal supporting cell differentiation
Stevant, I.; Abberbock, E.; Ridnik, M.; Weiss, R.; Swisa, L.; Futtner, C.; Maatouk, D.; Lovell-Badge, R.; Malysheva, V.; Gonen, N.
10.1101/2024.12.09.627451 — developmental biology — Posted on 2025-06-12
2498 Afadin-deficient retinas exhibit severe neuronal lamination defects but preserve visual functions
Ueno, A.; Sakuta, K.; Ono, H.; Hashio, A.; Tokumoto, H.; Watanabe, M.; Nishimoto, T.; Konishi, T.; Emori, Y.; Mizuno, S.; Hiratsuka, M.; Miyoshi, J.; Takai, Y.; Tachibana, M.; Koike, C.
10.1101/2024.12.24.630271 — neuroscience — Posted on 2025-06-12
2499 The mechanism of ribosomal recruitment during translation initiation on Type 2 IRESs
Bhattacharjee, S.; Abaeva, I.; Brown, Z.; Arhab, Y.; Fallah, H.; Hellen, C. U. T.; Frank, J.; Pestova, T.
10.1101/2025.06.11.659010 — molecular biology — Posted on 2025-06-11
2500 MITF maintains genome stability in non-melanocytic cell lineages and suppresses Hippo pathway signaling
Gudmundsdottir, D. H.; de Lomana, A. L. G.; Venkatesh, T. B.; Kirty, K.; Sigurdsson, S.; Vidarsdottir, L.; Dilshat, R.; Sveinbjornsdottir, E.; Ragnarsdottir, S.; Magnusson, D. H.; Bustos, M. R.; Steingrimsson, E.; Gudjonsson, T.; Sigurdsson, S.
10.1101/2025.06.09.658599 — molecular biology — Posted on 2025-06-11
2504 Multiple-level organizational logic of the locus coeruleus-norepinephrine system in structure and function
Zhang, C.-M.; Yang, Y.-X.; Li, F.-N.; Zhang, H.; Sun, L.; Li, J.; Yang, C.; Yue, Z.-F.; Feng, J.-S.; Li, Y.-L.; Zhang, R.-W.; He, J.; Du, X.-F.; Du, J.-L.
10.1101/2025.06.11.659024 — neuroscience — Posted on 2025-06-11
2505 Cognition-centric brain activity across diverse imaging tasks constrains the representation of mental health in task-evoked brain function
Korponay, C.; Cohen-Gilbert, J. E.; Kumar, P.; Harnett, N. G.; Medina, A. A.; Cheng, Y.; Forester, B. P.; Ressler, K. J.; Demsar, J.; Frederick, B. B.; Beckmann, C. F.; Harper, D. G.; Nickerson, L. D.
10.1101/2025.06.11.659091 — neuroscience — Posted on 2025-06-11
2507 Hippocampal Commissural Circuitry Shows Asymmetric cAMP-Dependent Synaptic Plasticity
Faiss, L.; Salivara, A.; Oldani, S.; Breustedt, J.-M.; Schmitz, D.; Rost, B.
10.1101/2025.06.11.659103 — neuroscience — Posted on 2025-06-11
2510 Cross-species comparative connectomics reveals the evolution of an olfactory circuit
Roberts, R.; Giez, C.; Dhawan, S.; Pang, S.; Randel, N.; Zhiyuan, L.; Gong, H.; Dekens, L.; DiFrisco, J.; Xu, C. S.; Hess, H.; Zlatic, M.; Cardona, A.; Prieto-Godino, L. L.
10.1101/2025.06.11.659158 — neuroscience — Posted on 2025-06-11
2511 Toward Granular Brain Intrinsic Connectivity Networks and Insights into Schizophrenia
Mirzaeian, S.; Jensen, K. M.; Ballem, R.; Andres Camazon, P.; Chen, J.; Calhoun, V.; Iraji, A.
10.1101/2025.06.11.659084 — neuroscience — Posted on 2025-06-11
2512 FEDRANN: effective overlap graph construction based on dimensionality reduction and approximate nearest neighbors
Zhang, J.-Y.; Miao, C.; Qiu, T.; Xia, X.; He, L.; He, J.; Sun, Y.; Zeng, T.; Li, Y.; Xu, X.; Ruan, Y.; Dong, Y.
10.1101/2025.05.30.656979 — bioinformatics — Posted on 2025-06-11
2513 Structural basis of RNA-guided transcription by a dCas12f-σE-RNAP complex
Xiao, R.; Hoffmann, F. T.; Xie, D.; Wiegand, T.; Palmieri, A. I.; Sternberg, S. H.; Chang, L.
10.1101/2025.06.10.658880 — biochemistry — Posted on 2025-06-11
2516 Telomeric Repeat-Containing RNA Increases in Aged Human Cells
Chu, H.-P. C.; Hsieh, Y.-H.; Tai, C.-H.; Yeh, M.-T.; Yang, P.-C.; Chen, Y.-C.; Yen, C.-P.; Han, D.-S.; Shen, H.-J.; Yeh, C.-H.
10.1101/2024.11.14.623513 — genomics — Posted on 2025-06-11
2517 Toward a genetic signature of resistance to activity-based anorexia in striatal projecting cortical neurons
Huang, K.; Magateshvaren Saras, M. A.; Conn, K.; Greaves, E.; Reed, F.; Tyagi, S.; Munguba, H.; Foldi, C. J.
10.1101/2025.03.09.642272 — neuroscience — Posted on 2025-06-11
2522 Biochemical engineering of 5hmdC-DNA using a Tet3 double-mutant
Sahin, H.; Islam, S.; Lee, A. H.; Ponzo, I.; Reichl, A.; Carell, T.; Giehr, P.
10.1101/2025.06.11.658802 — biochemistry — Posted on 2025-06-11
2528 Structures reveal how the Cas1-2/3 integrase captures, delivers, and integrates foreign DNA into CRISPR loci
Henriques, W. S.; Bowman, J.; Hall, L. N.; Gauvin, C. C.; Wei, H.; Kuang, H.; Zimanyi, C. M.; Eng, E. T.; Santiago-Frangos, A.; Wiedenheft, B.
10.1101/2025.06.10.658980 — molecular biology — Posted on 2025-06-11
2530 Recovering historical fish eDNA from museum-preserved Antarctic filter feeders via non-destructive metabarcoding.
Jeunen, G.-J.; Mills, S.; Bailie, M.; Mauvisseau, Q.; Lamare, M.; Mariani, S.; Pearman, W.; Zavodna, M.; Treece, J.; Ferreira, S.; Gemmell, N.
10.1101/2025.06.07.656140 — ecology — Posted on 2025-06-11
2531 Multimodal Evidence for Hippocampal Engagement and Modulation by Functional Connectivity-Guided Parietal TMS
Li, Z.; Trapp, N. T.; Bruss, J.; Liu, X.; Wu, K.; Chen, Z.; Etkin, A.; Howard, M. A.; Boes, A. D.; Jiang, J.
10.1101/2025.06.08.658503 — neuroscience — Posted on 2025-06-11
2532 A Numerical Alternative to MR Thermometry for Safety Validation of Multi-Channel RF Transmit Coils
Sadeghi-Tarakameh, A.; Schmidt, S.; Waks, M.; Lagore, R. L.; Grant, A.; Auerbach, E.; DelaBarre, L.; Knudsen, L.; Lenglet, C.; Vizioli, L.; Yacoub, E.; Adriany, G.; Metzger, G. J.; Ugurbil, K.; Eryaman, Y.
10.1101/2025.06.07.657475 — neuroscience — Posted on 2025-06-11
2538 Human fibrosarcoma cells selected for very-high doxorubicin resistance, acquire trabectedin and eribulin cross-resistance, remain sensitive to recombinant methioninase, and have increased c-MYC expression
Morinaga, S.; Han, Q.; Mizuta, K.; Kang, B. M.; Bouvet, M.; Yamamoto, N.; Hayashi, K.; Kimura, H.; Miwa, S.; Igarashi, K.; Higuchi, T.; Tsuchiya, H.; Demura, S.; Hoffman, R. M.
10.1101/2025.06.07.658455 — cancer biology — Posted on 2025-06-11
2539 Better antibodies engineered with a GLIMPSE of human data
Hepler, N. L.; Hill, A. J.; Jaffe, D. B.; Gibbons, M. C.; Pfeiffer, K. A.; Hilton, D. M.; Freeman, M.; McDonnell, W. J.
10.1101/2025.06.08.658113 — bioinformatics — Posted on 2025-06-11
2543 Structural and functional characterisation of isolated puff adder (B. arietans) serine proteases
Wilkinson, M. C.; Modahl, C.; Saviola, A.; Tianyi, F.; Harrison, R. A.; Casewell, N. R.
10.1101/2025.06.11.659063 — biochemistry — Posted on 2025-06-11
2544 Architecture of the bundle-shaped phycobilisome from Gloeobacter violaceus
Burtseva, A.; Slonimskiy, Y.; Baymukhametov, T.; Sinetova, M.; Maksimov, E. G.; Popov, V. O.; Boyko, K. M.; Sluchanko, N. N.
10.1101/2025.06.10.658930 — biochemistry — Posted on 2025-06-11
2545 Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO
Lindsey, G. L.; Hockley, T. K.; Gomez, A. V.; Marshall, A. C.; Brothers, W. R.; Finney, C. T.; Gross, J.; Fox, A. C.; Yeo, G. W.; Melillo, B.; Bond, C. S. S.; Cravatt, B. F.
10.1101/2025.06.10.658857 — biochemistry — Posted on 2025-06-11
2548 STING is a key driver of Japanese encephalitis virus induced inflammatory response
Chhabra, S.; Patel, D.; Sharma, K. B.; Sah, V.; Harshan, K.; Chauhan, S.; Kalia, M.
10.1101/2025.06.11.659027 — microbiology — Posted on 2025-06-11
2550 The Ambiguous Genetic Code of Methanogenic Archaea that Grow on Methylamines
Shalvarjian, K. E.; Chadwick, G.; Perez, P. I.; Woods, P.; Orphan, V. J.; Nayak, D. D.
10.1101/2025.06.11.659114 — microbiology — Posted on 2025-06-11
2555 Mutation or deletion of the Avr6 avirulence effector gene of Fulvia fulva leads to breakdown of the Cf-6 leaf mold resistance locus in tomato
Schol, C. R.; Fokkens, L.; Hu, A.; Jia, R.; de la Rosa, S.; Ökmen, B.; Hilgers, A. M.; van Zwoll, S. L.; Veenendaal, L. D. H.; Turner, M.; Monot, C.; Maeda, K.; Iida, Y.; de Wit, P. J. G. M.; Esselink, D.; Wolters, A.-M. A.; Bai, Y.; Joosten, M. H. A. J.; Mesarich, C. H.
10.1101/2025.06.11.659170 — microbiology — Posted on 2025-06-11
2556 Increased basal ganglia volume in older adults with tinnitus
San Martin, S. P.; Medel, V.; Breinbauer, H.; Delgado, C.; Delano, P. H.
10.1101/2025.06.08.658513 — neuroscience — Posted on 2025-06-11
2559 High-Throughput Targeted Drug Screening for NF1-associated High-Grade Gliomas with ATRX Deficiency
Dubey, S.; Rai, S.; Guillen, F.; Iyer, A.; Aung, S.; Yuan, M.; Eberhart, C. G.; Rodriguez, F. J.
10.1101/2024.12.14.628525 — cancer biology — Posted on 2025-06-11
2560 Fine-Tuning Protein Language Models Unlocks the Potential of Underrepresented Viral Proteomes
Sawhney, R.; Ferrell, B. D.; Dejean, T.; Schreiber, Z.; Harrigan, W.; Polson, S. W.; Wommack, K. E.; Belcaid, M.
10.1101/2025.04.17.649224 — bioinformatics — Posted on 2025-06-11
2565 The Sleep-Mood Connection: Temperament Modulates Neuroinflammation, Clock Genes, and Dopaminergic Receptors Expression in Rats
Carvalho, C.; Silva, F. E.; Carvalho, M.; Lima, J. E. C.; Chaves Filho, A. J.; Fries, G.; Sobreira-Neto, M.; Costa, D.; Fonteles, M.; Macedo, D. S.
10.1101/2025.06.09.658634 — animal behavior and cognition — Posted on 2025-06-11
2569 American mink as an animal model to study SARS-CoV-2 and vaccine response
Aaltonen, K.; Virtanen, J.; Kegler, K.; Venkat, V.; Kareinen, L.; Korhonen, E. M.; Niamsap, T.; Malmgren, R.; Korpela, J.; Naves, R. A.; Iso-Oja, M.; Svenns, S.; Haggvik, T.; Ojala, E.; Vapalahti, O.; Peura, J.; Sukura, A.; Ritvos, O.; Pasternack, A.; Nordgren, H.; Kant, R.; Sironen, T.
10.1101/2025.06.10.658224 — microbiology — Posted on 2025-06-11
2572 Connectivity Is All You Need: Inferring Neuronal Types with NTAC
Schwartzman, G.; Jourdan, B.; Garcia-Soriano, D.; Matsliah, A.
10.1101/2025.06.11.659184 — neuroscience — Posted on 2025-06-11
2574 EXTENDING PROTEIN LANGUAGE MODELS TO A VIRAL GENOMIC SCALE USING BIOLOGICALLY INDUCED SPARSE ATTENTION
Dejean, T. L.; Sawhney, R.; Harrigan, W.; Ferrell, B. D.; Schreiber, Z.; Polson, S. W.; Wommack, K. E.; Belcaid, M.
10.1101/2025.05.29.656907 — bioinformatics — Posted on 2025-06-11
2577 Optimization of Genome-wide CRISPR Screens using dual-guide RNA Infection with Cas9 Electroporation (DICE)
Purman, C.; Lu, C.; Modi, A.; Vijaykumar, V.; Flister, M.; den Hollander, A.; Kadri, S.; Stender, J. D.
10.1101/2025.06.09.658313 — genomics — Posted on 2025-06-11
2578 Translation Accuracy in E. coli
Stikeleather, R.; Ali, F.; Ho, W.-C.; Licknack, T.; Lynch, M.
10.1101/2025.04.18.649569 — evolutionary biology — Posted on 2025-06-11
2579 Single-cell transcriptional dynamics in a living vertebrate
Eck, E.; Moretti, B.; Schlomann, B. H.; Bragantini, J.; Lange, M.; Zhao, X.; VijayKumar, S.; Valentin, G.; Loureiro, C.; Franco, P. P.; Jollivet, C.; Motomochi, B.; Royer, L. A.; Oates, A. C.; Garcia, H. G.
10.1101/2024.01.03.574108 — developmental biology — Posted on 2025-06-11
2582 Ultra-wide-field, deep, adaptive two-photon microscopy
Yang, M.; Zhou, Z.-Q.; Lang, S.; Zheng, H.; Chen, S.; Li, T.; Stas, E.; Zhang, L.; Zhang, Z.; Uzungil, V.; Liu, Q.; Huang, Y.; Jing, L.; Li, Y.; Jia, H.; Li, M.; Li, X.; Li, J.; Tan, Y.; Yan, G.; Schultz, S. R.
10.1101/2025.06.07.658419 — neuroscience — Posted on 2025-06-11
2583 Computational enzyme design by catalytic motif scaffolding
Braun, M.; Tripp, A.; Chakatok, M.; Kaltenbrunner, S.; Fischer, C.; Totaro, M. G.; Moser, M.; Stoll, D.; Bijelic, A.; Elaily, W.; Hoch, S. Y. Y.; Lechner, H.; Rossi, F.; Aleotti, M.; Hall, M.; Oberdorfer, G.
10.1101/2024.08.02.606416 — biochemistry — Posted on 2025-06-11
2585 Magellon - an extensible platform for cryo-EM data visualization, management, and processing
Khoshbin, B.; Damodar, P.; Garje, R. R.; Schotanus, F. H.; Nair, N.; Wei, L.; Schaefer, J.-H.; Lander, G. C.; Cianfrocco, M. A.; Stagg, S. M.
10.1101/2025.06.09.658726 — biophysics — Posted on 2025-06-11
2586 A reversible feedback mechanism regulating mitochondrial heme synthesis
Chitrakar, I.; Roberson, A. B.; Ayres-Galhardo, P. H.; Brown, B. L.
10.1101/2025.06.09.658730 — biochemistry — Posted on 2025-06-11
2589 Measles vaccine attenuation comprises innate immune cell infection and interferon responses
Andres, F. G.; Parusel, S.; Siering, O.; Acosta, F. M.; Skeele, D. A.; Ayasoufi, K.; Cattaneo, R.; Sawatsky, B.; Pfaller, C. K.
10.1101/2025.06.09.657851 — immunology — Posted on 2025-06-11
2590 Selective targeting of IL-1RAP-dependent eosinophilic inflammation in allergic fungal airway disease
Williams, T. J.; Griffiths, J. S.; Gonzales-Huerta, L. E.; Bell, D.; Reed, A. K.; Shah, A.; Naglik, J. R.; Armstrong-James, D.
10.1101/2025.06.09.658569 — immunology — Posted on 2025-06-11
2591 ALOX12B overexpression in the skin drives inflammasome/Th17 signaling axis to promote inflammation in the mouse model and human patients
Singh, S.; Ahmed, F.; Fatima, N.; Cholleti Sai, N.; Bhuktar, H.; Khan, R. A.; Afroz, S.; Battu, S.; Reddy, K. K.; Jagadeb, M.; Naz, S.; Sharma, N.; Philips, A. M.; Priscilla, T.; Vindal, V.; Kumar, M. J. M.; Oruganti, S.; Pal, M.; Reddanna, P.; Khan, N.
10.1101/2025.06.09.658245 — immunology — Posted on 2025-06-11
2592 Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis
Georgiev, P.; Johnson, S.; Kurmi, K.; Hu, S.-H.; Han, S.; Patterson, D.; Nguyen, T.; Huang, L.; Liang, D.; Goldman, N.; Conway, T.; Creasey, H.; Rowe, J.; Haigis, M. C.; Sharpe, A. H.
10.1101/2025.06.09.658561 — immunology — Posted on 2025-06-11
2594 Oblique Thick Light-Sheet Microscopy with Spatiotemporal 3D Localization for RNA Imaging in Intact 50 μm-Thick Sections
Cai, L.; Song, Q.; Cao, D.; Li, Q.; Wu, W.; Xiao, Y.; Chen, X.; Huang, S.; Yang, J.; Zhang, Y.; Huang, Z.-L.
10.1101/2025.06.09.658547 — biophysics — Posted on 2025-06-11
2597 Establishing a standardized genetic toolkit for the radiation-resistant extremophile Deinococcus radiodurans
Simmons, T. R.; Cordova, A.; Grismore, K. B.; Moline, L. C.; Stankes, A. C.; Johnson, J.; Bok, C.; Contreras, L. M.
10.1101/2025.06.09.658681 — bioengineering — Posted on 2025-06-11
2599 Optimization of Genome-wide CRISPR Screens using dual-guide RNA Infection with Cas9 Electroporation (DICE)
Stender, J. D.; Purman, C.; Lu, C.; Modi, A.; Vijaykumar, V.; Flister, M.; den Hollander, A.; Kadri, S.
10.1101/2025.06.09.658313 — genomics — Posted on 2025-06-11
2600 Defective plasticity in dermatomyositis patients muscle stem cells is associated with sustained intrinsic inflammatory signaling and disruption of the histone H3.3 chromatin loading pathway
Bouchereau, W.; Chenane, L.; Lessard, L.; Weiss-Gayet, M.; Cardona, Y.; Mounier, R.; Gallay, L.; Allenbach, Y.; Benveniste, O.; Corpet, A.; Chazaud, B.; Lomonte, P.
10.1101/2025.06.09.658580 — molecular biology — Posted on 2025-06-11
2601 Unlocking River Biofilm Microbial Diversity: A Comparative Analysis of Sequencing Technologies
Anderson, M. A. J.; Thorpe, A. C.; Busi, S. B.; Gweon, H. S.; Warren, J.; Walsh, K.; Read, D. S.
10.1101/2025.06.09.658576 — molecular biology — Posted on 2025-06-11
2604 How Ikaros and Aiolos homo- and heterodimers drive gene expression to ensure B cell development
Deau, M.-C.; Heizmann, B.; Aukenova, A.; Heydt, Q.; Marchal, P.; Charvet, C.; le Gras, S.; Billas, I. M. L.; van Essen, D.; Saccani, S.; Kastner, P.; Chan, S.
10.1101/2025.06.09.658591 — immunology — Posted on 2025-06-11
2606 DEVELOPMENT OF A POTENT MONOCLONAL ANTIBODY FOR TREATMENT OF HUMAN METAPNEUMOVIRUS INFECTIONS
Harris, E. D.; McGovern, M.; Pernikoff, S.; Ikeda, R.; Kipnis, L.; Hannon, W.; Sobolik, E. B.; Gray, M.; Greninger, A. L.; He, S.; Chin, C.-N.; Fu, T.-M.; Pancera, M.; Boonyaratanakornkit, J.
10.1101/2025.06.09.657676 — immunology — Posted on 2025-06-11
2610 Cholesterol-Responsive Interaction of NFE2L1-INSIG1 Controls VLDL Secretion and MASH Pathogenesis
Deng, S.; Freed, J.; Lee, G. Y.; Askin, G.; Cao, Z.; Cakici, O.; Yuan, B.; Hui, S. T.; Graupera, I.; Hotamisligil, G. S.
10.1101/2025.06.09.657856 — physiology — Posted on 2025-06-11
2611 Highly accurate protein structure prediction-based virtual docking pipeline accelerating the identification of anti-schistosomal compounds
Cheng, W.; Gu, M.; Wang, Y.; Wang, J.; Li, S.; Chen, G.; Chen, X.; Oyeyemi, O. T.; Hong, Y.; Hu, W.; WANG, J.
10.1101/2025.06.09.658570 — pathology — Posted on 2025-06-11
2614 Loss of B cell tolerance at the T2/T3a B cell transition is a convergent pathogenic mechanism in common variable immunodeficiency
Hillier, K.; Yuen, G.; Hui, A.; Kumar, S.; Roy, P. G.; McColgan, J.; Zaldana, K.; Premo, K.; Kaneko, N.; Ingram, N.; Barmettler, S.; Ghebremichael, M.; Walter, J. E.; Perugino, C. A.; Das, J.; Farmer, J. R.; Pillai, S.
10.1101/2025.06.07.658167 — immunology — Posted on 2025-06-11
2615 EGR3 Deletion Rescues Developmental and Epileptic Encephalopathy in Kcna1-null Mice
Mazumder, A. G.; Karedia, S.; Adhyapak, N.; Bass, J. S.; Kamen, J. L.; Jankovic, M.; Miao, Q.; Gallitano, A. L.; Saltzman, A. B.; Jain, A.; Malovannaya, A.; Glasscock, E.; Aiba, I.; Noebels, J. L.; Krishnan, V.
10.1101/2025.06.07.658422 — neuroscience — Posted on 2025-06-11
2618 Bioinspired Oxidized mRNA Lipid Nanoparticles for Ex Vivo Engineering of Chimeric Antigen Receptor Macrophages Targeting Solid Tumors
Mukalel, A. J.; Tylek, T.; O'Brien, E.; Frazee, C.; Geisler, H. C.; Li, J.; Thatte, A. S.; Safford, H. C.; Figueroa-Espada, C. G.; Alameh, M.-G.; Hamilton, A. G.; Mai, D.; Sheppard, N. C.; June, C. H.; Weissman, D.; Spiller, K. L.; Mitchell, M. J.
10.1101/2025.06.07.658363 — bioengineering — Posted on 2025-06-11
2619 Structural Identification of Major Molecular Determinants for Phosphotyrosine Recognition in Tyrosine Kinases Reveals Tumour Promoting and Suppressive Functions
Cheng, N.; Millan-Barea, L. R.; Creixell, M.; Barr, A. R.; Kong, Y. W.; Joughin, B. A.; Lopez, C. K.; Lengefeld, J.; Clarke, J.; Liu, C.; Sriram, G.; Gonzalez-Robles, T. J.; van de Kooij, B.; Savickas, S.; Schoof, E. M.; Johnson, J. L.; Bakal, C.; Cantley, L. C.; Chiarle, R.; Pritchard, J.; Hubbard, S.; Huntly, B. J. P.; Hemann, M.; Creixell, P.; Yaffe, M. B.
10.1101/2025.06.10.658871 — biochemistry — Posted on 2025-06-11
2622 MAFA Phosphorylation Controls Beta-Cell Identity and Sex-Specific Pancreatic Disease Outcomes
Ka, M.; Druillennec, S.; Chabi, S.; Roulle, C.; NG, D. Y.; PECHOUX, C.; Messaoudi, C.; Walczak, C.; Soler, M.-N.; Besse, L.; Lecoin, L.; Majo, S.; Gradwohl, G.; Eychene, A.; Terris, B.; Pouponnot, C.; DUVILLIE, B.
10.1101/2025.06.11.659123 — cell biology — Posted on 2025-06-11
2623 Neural basis of cognitive control signals in anterior cingulate cortex during delay discounting
Seamans, J. K.; Emberly, E.; White, S. M.; Morningstar, M.; Linsenbardt, D. N.; Ma, B.; Czachowski, C. L.; Lapish, C.
10.1101/2024.06.07.597894 — neuroscience — Posted on 2025-06-11
2626 Single-cell multi-omic analysis of mesenchymal cells reveals molecular signatures and putative regulators of lung allograft fibrosis
Lu, L.; McLinden, A. P.; Walker, N. M.; Vittal, R.; Wang, Y.; Russell, S. T.; Combs, M. P.; Welch, J. D.; Lama, V. N.
10.1101/2024.11.27.625698 — bioinformatics — Posted on 2025-06-11
2629 Cross-species Standardised Cortico-Subcortical Tractography
Assimopoulos, S.; Warrington, S.; Folloni, D.; Bryant, K.; Tang, W.; Jbabdi, S.; Heilbronner, S.; Mars, R. B.; Sotiropoulos, S. N.
10.1101/2025.04.29.651254 — neuroscience — Posted on 2025-06-11
2630 Afadin-deficient retinas exhibit severe neuronal lamination defects but preserve visual functions
Ueno, A.; Sakuta, K.; Ono, H.; Hashio, A.; Tokumoto, H.; Watanabe, M.; Nishimoto, T.; Konishi, T.; Emori, Y.; Mizuno, S.; Hiratsuka, M.; Miyoshi, J.; Takai, Y.; Tachibana, M.; Koike, C.
10.1101/2024.12.24.630271 — neuroscience — Posted on 2025-06-11
2635 Ultra-wide-field, deep, adaptive two-photon microscopy
Yang, M.; Zhou, Z.-Q.; Lang, S.; Zheng, H.; Chen, S.; Li, T.; Stas, E.; Zhang, L.; Zhang, Z.; Uzungil, V.; Liu, Q.; Huang, Y.; Jing, L.; Li, Y.; Jia, H.; Li, M.; Li, X.; Li, J.; Tan, Y.; Yan, G.; Schultz, S. R.
10.1101/2025.06.07.658419 — neuroscience — Posted on 2025-06-11
2638 Evaluating transportability of in-vitro cellular models to in-vivo human phenotypes using gene perturbation data
Howe, L. J.; Aulchenko, Y.; Davey Smith, G.; Davies, N. M.; Esparza Gordillo, J.; Johnson, T.; Liu, J. Z.; Richardson, T. G.; Sanseau, P.; Scott, R. A.; Seaton, D. D.; Sharma, A.; Cortes, A.
10.1101/2024.10.17.618648 — genetics — Posted on 2025-06-11
2640 A Molecular, Spatial, and Regulatory Atlas of the Hydra vulgaris Nervous System
Morris Little, H.; Primack, A. S.; Tsverov, J.; Mühlbauer, S.; Cox, B. D.; Busse, C.; Schneid, S.; Louwagie, A.; Cazet, J. F.; David, C. N.; Farrell, J. A.; Juliano, C.
10.1101/2023.03.15.531610 — developmental biology — Posted on 2025-06-11
2641 Failed Cellular Surveillance Enables Pathogenic Matrix Deposition in a COL2A1-Related Osteoarthritis
Yammine, K. M.; Abularach, S. M.; Xiong, M.; Kim, S.-y.; Bikovtseva, A. A.; Butty, V.; Schiavoni, R. P.; Bateman, J. F.; Lamande, S. R.; Shoulders, M. D.
10.1101/2024.11.07.622468 — cell biology — Posted on 2025-06-11
2642 Microglia Adopt Temporally Specific States after Irradiation, Correlating with Neuronal Asynchrony
Lastra Romero, A.; Preka, E.; Pizzirusso, G.; Arroyo-Garcia, L. E.; Zisiadis, G. A.; Oliva-Vilarnau, N.; Ruchiy, Y.; Seitz, T.; Zhou, K.; Gonzalez Isla, A.; Friess, L.; Sun, Y.; Querol Canut, M.; Shamikh, A.; Xu, Y.; Zhu, C.; Rodrigues, C.; Fisahn, A.; Joseph, B.; Carlson, L.-M.; Fragkopoulou, A.; Lauschke, V.; Betsholtz, C.; Osman, A.; Blomgren, K.
10.1101/2025.02.15.638339 — neuroscience — Posted on 2025-06-11
2644 Single-cell multiomics identifies both shared and unique features of immune dysfunction in Parkinson's disease and inflammatory bowel disease colon, plasma and stool
Bolen, M. L.; Buendia, M.; Shi, J.; Staley, H.; Kachergus, J. M.; Efron, P. A.; Park, G.; Nagpal, R.; Alvarez, S. D.; Xue, Q.-S.; McFarland, N. R.; Zimmermann, E. M.; Forsmark, C. E.; Menees, K. B.; Salas, A.; Thompson, E. A.; Tansey, M. G.
10.1101/2025.04.29.651228 — neuroscience — Posted on 2025-06-11
2647 Multi-task benchmarking of single-cell multimodal omics integration methods
Liu, C.; Ding, S.; Kim, J. H.; Long, S.; Xiao, D.; Ghazanfar, S.; Yang, P.
10.1101/2024.09.15.613149 — bioinformatics — Posted on 2025-06-11
2648 Genomic Insights into a Versatile Deep-Sea Methanotroph Constituting the Rare Biosphere of a Brazilian Carbonate Mound Complex
Butarelli, A. C.; Nakamura, F. M.; Vilela Peres, F.; Modolon da Silva, F.; Bendia, A.; Basti, R.; Mahiques, M.; Sumida, P.; Pellizari, V. H.
10.1101/2025.06.09.658676 — microbiology — Posted on 2025-06-11
2649 Small tau aggregates exhibit disease-specific molecular profiles across tauopathies
Böken, D.; Huang, M.; Wu, Y.; Fertan, E.; Lam, J. Y. L.; Meisl, G.; Baig, S.; Rowe, J.; Smith, C.; Quaegebeur, A.; Cox, D.; McEwan, W. A.; Klenerman, D.
10.1101/2025.06.10.658934 — neuroscience — Posted on 2025-06-11
2650 Large-scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of α-synuclein aggregation
Neupane, S.; Nikolic, L.; Maraio, L.; Goiran, T.; Karpilovsky, N.; Sellitto, S.; Bouris, V.; Yin, J.-A.; Melki, R.; Fon, E. A.; De Cecco, E.; Aguzzi, A.
10.1101/2025.06.10.658866 — neuroscience — Posted on 2025-06-11
2651 Lowering the HTT1a transcript as an effective therapy for Huntingtons disease
Papadopoulou, A. S.; Alterman, J.; Landles, C.; Smith, E. J.; Conroy, F.; Phillips, J.; Canibano-Pico, M.; Nita, I. M.; Osborne, G. F.; Iqbal, A.; Aldous, S. G.; Bondulich, M. K.; Gomez-Paredes, C.; Sathasivam, K.; O'Reilly, D.; Echeverria, D.; Bobkov, K.; Greene, J. R.; Aronin, N.; Khvorova, A.; Bates, G. P.
10.1101/2025.06.10.658804 — neuroscience — Posted on 2025-06-11
2657 Scalable 3D Bioprinting of Human Islets in a Pancreatic Decellularized Extracellular Matrix-Enriched Bioink for Beta-Cell Replacement Therapy
Jeong, W.; Perrier, Q.; Rengaraj, A.; Byers, L.; Gonzalez, G. C.; Peveri, E.; Miller, J.; Bottino, R.; Mikhailov, A. V.; Fraker, C.; Opara, E. C.; Tomei, A. A.; Lee, S. J.; Orlando, G.; Asthana, A.
10.1101/2025.06.06.658360 — bioengineering — Posted on 2025-06-11
2662 The genome of the charismatic sea star Linckia laevigata
Trimble, C. J.; Laumer, C. E.; Lamare, M.; Carter, H. F.; Byrne, M.; Fellner, M.; Williams, S. T.; Kenny, N. J.
10.1101/2025.06.09.658723 — genetics — Posted on 2025-06-11
2666 Introducing PIGMO, a novel PIGmented MOuse model of Parkinson's disease
Chocarro, J.; Marana, S.; Espelosin, M.; Rico, A. J.; Ariznabarreta, G.; Lorenzo-Ramos, E.; Ilarduya, M. M.; Hernandez-Alcoceba, R.; Chillon, M.; Vila, M.; Kordower, J.; Schapira, A. H. V.; Garcia-Osta, A.; Cuadrado-Tejedor, M.; Lanciego, J. L.
10.1101/2025.05.09.653000 — neuroscience — Posted on 2025-06-11
2668 Multi-agent AI System for High Quality Metadata Curation at Scale
Mondal, R.; Dhruw, N. K.; Sen, M.; Sengupta, S.; Maity, W.; Palapetta, S.; Jha, A.
10.1101/2025.06.10.658658 — scientific communication and education — Posted on 2025-06-11
2669 Tissue-Specific Iron Levels Modulate Lipid Peroxidation and the FLASH Radiotherapy Effect
Vilaplana Lopera, N.; Kim, J.; Nam, G.; Tullis, I. D. C.; Paillas, S.; Ruan, J.-L.; Lee, P. J.; Jiang, Y.; Park, S.; Hou, T.; Nasir, A.; Charlesworth, E.; Walker, E.; Abu-Halawa, A.; Hill, M. A.; Choi, C.; Lee, I. J.; Jeong, Y.; Lakhal-Littleton, S.; Then, C. K.; Shen, S.-C.; Giaccia, A.; Petersson, K.; Moon, E. J.
10.1101/2025.05.14.653978 — cancer biology — Posted on 2025-06-11
2672 ATP2B1 expression identifies human hematopoietic stem cells across ontogeny with superior repopulation and self-renewal capacity
Varesi, A.; Nagree, M.; Di Biasio, I.; Zeng, A. G. X.; Shah, S.; Kim, H.; Zhang, M.; Murison, A.; Dick, J. E.; Xie, S. Z.
10.1101/2025.06.11.659017 — cell biology — Posted on 2025-06-11
2673 ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chains
Reinders, M.; Kravic, B.; Gahlot, P.; van den Boom, J.; Schulze, N.; Levantovsky, S.; Kleine, S.; Kaiser, M.; Kulathu, Y.; Behrends, C.; Meyer, H.
10.1101/2025.06.10.656592 — cell biology — Posted on 2025-06-11
2674 Human meibomian gland organoids to study epithelial homeostasis and dysfunction
Yu, C.; Wan, X.; Wei, J.; Wu, X.; Xu, Z.; Wang, X.; Mi, Y.; Zhang, Y.; Wu, D.; Zhou, X.; Le, Q.; Xu, J.; Zhao, C.; Sun, X.; Zhou, X.; Hong, J.; Zhao, B.
10.1101/2025.06.10.658800 — cell biology — Posted on 2025-06-11
2675 The microcephaly-associated protein YIPF5 differentially regulates ER-export
Bruno, F.; Anitei, M.; Di Fraia, D.; Durso, W.; Dau, T.; Cirri, E.; Sannai, M.; Valkova, C.; Maldutyte, J.; Miller, E. A.; Rubio, I.; Garloff, V.; Kersten, N.; Farias, G. G.; Ori, A.; Mestres, I.; Calegari, F.; Kaether, C.
10.1101/2025.06.11.659036 — cell biology — Posted on 2025-06-11
2676 The mitochondrial unfolded protein response and metabolic reprogramming promote PASMC proliferation in response to sphingosine kinase-1/sphingosine-1-phosphate signaling
Lockett, A. D.; Snow, A.; Adogamhe, P.; Sysol, J.; Yadav, M.; Mubuuke, T.; Gomes, M. T.; Cook, T.; Fisher, A.; Aldred, M.; Machado, R. F.
10.1101/2025.06.10.658872 — cell biology — Posted on 2025-06-11
2679 Dynamic regulation of origin firing factors links CDK activity to dormant origin activation
Hossain, M. S.; Sansam, C. G.; Wittig, K. A.; Noble, T. D.; Boyd, K. A.; Sansam, C. L.
10.1101/2025.06.10.657920 — cell biology — Posted on 2025-06-11
2680 TrAEL-seq captures DNA replication dynamics in mammalian cells
Kara, N.; Biggins, L.; Grinkevich, V.; Whale, A.; Garran Garcia, P.; Srinivasan, J.; Rugg-Gunn, P.; Andrews, S.; Parry, A.; Robinson, H. M. R.; Houseley, J.
10.1101/2025.06.09.658559 — molecular biology — Posted on 2025-06-11
2682 Maintenance of chronic neuroinflammation in multiple sclerosis via interferon signaling and CD8 T cell-mediated cytotoxicity
Raza, S. A.; Enose-Akahata, Y.; Blazier, A.; Guerra, L. M.; Beck, E. S.; Gaitan, M. I.; Ngouth, N.; Drijvers, J. M.; Dammer, E. B.; Moodley, D.; Johnson, K. R.; Absinta, M.; TURNER, T. J.; Ransohoff, R. M. J.; Jacobson, S.; Ofengeim, D.; Cahir-McFarland, E.; Reich, D. S.
10.1101/2025.06.09.658729 — immunology — Posted on 2025-06-11
2684 Circadian Variation in Salivary Oxytocin in young adult women
Teixeira de Almeida, M.; Quattrocchi, L.; Perroud, N.; Aboulafia Brakha, T.
10.1101/2025.03.26.645423 — neuroscience — Posted on 2025-06-11
2685 Neural responses underlying ITD discrimination as a function of sensory reliability in the barn owl
Fischer, B. J.; Shadron, K.; Keller, C. H.; Bala, A. D. S.; Cazettes, F.; Ferger, R.; Pena, J. L.
10.1101/2025.06.10.658945 — neuroscience — Posted on 2025-06-11
2686 Interdependency between oxytocin and dopamine in trust-based learning in mice
Budniok, S.; Callaerts-Vegh, Z.; Bakermans-Kranenburg, M.; Bosmans, G.; D'Hooge, R.
10.1101/2025.06.11.659016 — neuroscience — Posted on 2025-06-11
2687 Brain cholesterol metabolites cause significant neurodegeneration in human iPSC-derived neurons
Feng, Y.; Mazumder, B.; Konno, T.; Hui, E.; Brockhoff, M.; Davi, V.; Lu, M.; Ward, E. N.; Stephens, A.; Dai, W.; Fernandez-Villegas, A.; Fusco, G.; Ali Asgari, M.; Avezov, E.; De Simone, A.; Wang, Y.; Griffiths, W. J.; Kaminski, C. F.; Kaminski Schierle, G. S.
10.1101/2025.06.10.656594 — neuroscience — Posted on 2025-06-11
2688 Dynamic regulation of mRNA acetylation at synapses by spatial memory in mouse hippocampus
Zhou, H.-Q.; Zhu, Z.; Zhang, J.-W.; Lin, W.-P.; Jin, H.-J.; Ding, Y.-Y.; Liu, S.; Yin, D.-M.
10.1101/2024.06.01.596932 — neuroscience — Posted on 2025-06-11
2691 Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer
Zhang, C.; Zhang, Z.; Wu, Y.; Wu, Y.; Cheng, J.; Luo, K.; Li, Z.; Zhang, M.; Wang, J.; Zhang, X.; Li, Y.
10.1101/2024.05.21.595220 — cancer biology — Posted on 2025-06-11
2694 Future climate and land use change will equally impact global terrestrial vertebrate diversity
Hari, C.; Hickler, T.; Hof, C.; Reyer, C. P. O.; Vanderkelen, I.; Voskamp, A.; Biber, M. F.; Fischer, M.; Davin, E. L.
10.1101/2024.12.13.627895 — ecology — Posted on 2025-06-11
2695 A globally influential area-condition metric is a poor proxy for invertebrate biodiversity
Duffus, N. E.; Atkins, T. B.; zu Ermgassen, S. O. S. E.; Grenyer, R.; Bull, J. W.; Castell, D. A.; Stone, B.; Tooher, N.; Milner-Gulland, E. J.; Lewis, O. T.
10.1101/2024.10.02.616290 — ecology — Posted on 2025-06-11
2696 Nephron segmentation and patterning in kidney organoids can be modulated by distinct FGF subfamily members
Zylberberg, A. K.; Scully, E. I.; Er, P. X.; Baric, H.; Scurr, M.; Xie, M.; Peiris, T.; Howden, S. E.; Lawlor, K. T.; Little, M. H.
10.1101/2025.06.10.658766 — developmental biology — Posted on 2025-06-11
2697 Cross-species insemination reveals mouse sperm ability to locate and cross the fish micropyle
Garibova, S.; Stickler, E.; AlAli, F.; Abdulla, M. A.; Sathappan, A.; Da'as, S.; Ghanem, L.; Djekidel, M. N.; Portman, R.; Avella, M.
10.1101/2025.03.29.646094 — developmental biology — Posted on 2025-06-11
2698 Transcriptional Dynamics Uncover the Role of BNIP3 in Mitophagy during Muscle Remodeling in Drosophila
Taoka, H.; Murakawa, T.; Kawaguchi, K.; Koizumi, M.; Kaminishi, T.; Sakamaki, Y.; Tanaka, K.; Harada, A.; Inoue, K.; Kanki, T.; Ohkawa, Y.; Fujita, N.
10.1101/2024.12.30.630714 — cell biology — Posted on 2025-06-11
2703 A spatial long-read approach at near-single-cell resolution reveals developmental regulation of splicing and polyadenylation sites in distinct cortical layers and cell types.
Foord, C.; Prjibelski, A. D.; Hu, W.; Michielsen, L.; Vandelli, A.; Narykov, O.; Evans, B.; Hsu, J.; Belchikov, N.; Jarroux, J.; He, Y.; Ross, M. E.; Hajirasouliha, I.; Tartaglia, G. G.; Korkin, D.; Tomescu, A. I.; Tilgner, H. U.
10.1101/2025.06.10.658877 — genomics — Posted on 2025-06-10
2704 Quantitative trait loci mapping of gene expression and chromatin accessibility in primary fibroblast reveals shared allelic effects between Latin American and European ancestries
Boltz, T.; Bot, M.; Lapinska, S.; Schwarz, T.; Hou, K.; Garske, K. M.; Freund, M. K.; Bearden, C. E.; Macaya, G.; Lopez-Jaramillo, C.; Freimer, N. B.; Boks, M. P.; Kahn, R. S.; Pasaniuc, B.; Ophoff, R. A.
10.1101/2025.06.09.658613 — genomics — Posted on 2025-06-10
2705 Deciphering the dynamic proteome of multiciliated cells
Boutin, C.; Rosnet, O.; Touret, M.; Audebert, S.; Camoin, L.; Dussert, S.; Brouilly, N.; Thome, V.; Fortun, D.; Borg, J.-P.; Kodjabachian, L.
10.1101/2025.06.10.658933 — cell biology — Posted on 2025-06-10
2706 A Foraging-Theory-Based Model Captures the Spectrum of Human Behavioral Diversity in Sequential Decision Making
Harrell, D.; Zid, M.; Laurie, V.-J.; Chen, C.; Grissom, N.; Darrow, D. P.; Ebitz, B. R.; Herman, A. B.
10.1101/2025.05.06.652482 — neuroscience — Posted on 2025-06-10
2708 CRISPR-mediated knockdown of oxytocin receptor in extended amygdala reduces stress-induced social avoidance and vigilance
Salazar, V. C.; Boender, A.; Seelke, A.; Gaard, L.; Mederos, S.; Rogers, S.; Gutierrez, X.; Bales, K.; Young, L.; Trainor, B. C.
10.1101/2025.06.10.658921 — neuroscience — Posted on 2025-06-10
2710 Essentialome-Wide Multigenerational Imaging Reveals Mechanistic Origins of Cell Growth Laws
Eaton, D. S.; Sanchez, C.; Gutierrez-Lopez, L.; Shenker, J. Q.; Goulev, Y.; Watson, B. R.; Henriot, V.; Garner, E. C.; Justman, Q. A.; Moffitt, J. R.; Paulsson, J.
10.1101/2025.06.10.658525 — systems biology — Posted on 2025-06-10
2711 Sex Differences in the Cancer Proteome
Zhu, C.; Zeltser, N.; Oh, J.; Li, C. H.; Boutros, P. C.
10.1101/2025.03.14.643396 — cancer biology — Posted on 2025-06-10
2712 Senescent human fibroblasts have increased FasL expression and impair the tumor immune response
Cruz, M.; Dulong, J.; Mansour Nehmo, G.; Sonn, A.; Moquin-Beaudry, G.; Benabdallah, B.; Le, O.; Beausejour, C.
10.1101/2024.06.10.598270 — cancer biology — Posted on 2025-06-10
2713 Fine-Tuning Protein Language Models Unlocks the Potential of Underrepresented Viral Proteomes
Dejean, T.; Sawhney, R.; Ferrell, B. D.; Schreiber, Z.; Harrigan, W.; Polson, S. W.; Wommack, K. E.; Belcaid, M.
10.1101/2025.04.17.649224 — bioinformatics — Posted on 2025-06-10
2715 Intervertebral disc impairments in a mouse model of Alzheimer's Disease
Gonzalez, C. C.; Schurman, C. A.; Wilson, K. A.; Schilling, B.; Ellerby, L. M.; Tang, S. Y.
10.1101/2025.05.24.655931 — bioengineering — Posted on 2025-06-10
2716 Genetic differences in plasticity across environmental scales determine fitness along an ecological gradient
Walter, G. M.; Emma, G.; Terranova, D.; Clark, J.; Cozzolino, S.; Hiscock, S.; Cristaudo, A.; Bridle, J.
10.1101/2025.03.19.644087 — evolutionary biology — Posted on 2025-06-10
2719 Immune-mediated inflammation modulates the thalamostriatal circuitry regulating depression-like behaviour in both mice and humans
Sharma, D.; Andrianova, L.; McGonigal, R.; Gardner-Stephen, K.; al Fadhel, H.; Sunzini, F.; Stefanov, K.; Barrie, J. A.; Hohne, R.; Saathoff, M.; Karabalci, Y.; Montes Gomez, A.; Bourgognon, J.-M.; Thornton, P.; Basu, N.; Cole, J. J.; Craig, M. T.; Cavanagh, J. T.
10.1101/2024.06.26.600791 — neuroscience — Posted on 2025-06-10
2724 Identification of a new inhibitor of Ran GTPase with therapeutic value in epithelial ovarian cancer
Boudhraa, Z.; Tian, X.; Gam, R.; Ritch, S.; Kendall-Dupont, J.; Carmona, E.; Provencher, D.; Wu, J. H.; Mes-Masson, A.-M.
10.1101/2025.03.02.641080 — cancer biology — Posted on 2025-06-10
2727 mRNArchitect: sequence design of mRNA medicines
Budzinska, M. A.; Zardbani, M.; Sidharta, M. P.; Waterhouse, J.; Leonard, T. E.; Ghodasara, A.; Lakshman Das, S.; Chang, R. Y.; Chaudhary, N.; Cheetham, S. W.; Mercer, T. R.; Gunter, H. M.
10.1101/2024.12.03.626696 — bioinformatics — Posted on 2025-06-10
2728 Listen, who is it? A novel method for studying the nightly and annual phenologies of cave bat communities in data deficient areas of the world.
Labadie, M.; Morand, S.; Caron, A.; De Nys, H. M.; Niama, F. R.; Nguilili, F.; TOBI, N.-; Bourgarel, M.; Bas, Y.; Roemer, C.
10.1101/2025.02.22.639615 — ecology — Posted on 2025-06-10
2729 Nephron segmentation and patterning in kidney organoids can be modulated by distinct FGF subfamily members
Zylberberg, A. K.; Scully, E. I.; Er, P. X.; Baric, H.; Scurr, M.; Xie, M.; Peiris, T.; Howden, S. E.; Lawlor, K. T.; Little, M. H.
10.1101/2025.06.10.658766 — developmental biology — Posted on 2025-06-10
2730 Neural crest induction requires SALL4-mediated BAF recruitment to lineage specific enhancers
Demurtas, M.; Barnada, S. M.; Van Domselaar, E.; Mitchell, Z. H.; Deelen, L. L.; Trizzino, M.
10.1101/2025.06.10.658805 — developmental biology — Posted on 2025-06-10
2733 Perirhinal cortex structure and function is dysregulated by corticosteroid treatment
Claydon, M. D. B.; Troy, O.; Birnie, M. T.; Kershaw, Y. M.; Barker, G. R. I.; Warburton, E. C.; Bortolotto, Z. A.; Lightman, S. L.; Conway-Campbell, B. L.
10.1101/2025.06.06.658287 — neuroscience — Posted on 2025-06-10
2736 Spatial Image Gradient Estimation from the Diffusion MRI Profile
Aganj, I.; Feiweier, T.; Kirsch, J. E.; Fischl, B. R.; van der Kouwe, A. J.
10.1101/2025.06.06.658348 — bioengineering — Posted on 2025-06-10
2737 Structural basis of RNA-guided transcription by a dCas12f-σE-RNAP complex
Xiao, R.; Hoffmann, F. T.; Xie, D.; Wiegand, T.; Palmieri, A. I.; Sternberg, S. H.; Chang, L.
10.1101/2025.06.10.658880 — biochemistry — Posted on 2025-06-10
2738 Purification of post-transcriptionally modified tRNAs for enhanced cell-free translation systems
Kalb, E.; Alejo, J.; Dias-Fields, L.; Knudson, I.; Davisson, J.; Maldonado, E.; Chattrakun, K.; Lin, S.; Schepartz, A.; Zhang, S.; Blanchard, S.; Engelhart, A. E.; Adamala, K. P.
10.1101/2025.06.10.658963 — biochemistry — Posted on 2025-06-10
2739 Early life environments shape adult cardiometabolic health during rapid lifestyle change
Petersen, R. M.; Tennyson, R.; A/P Tan Boon Huat, T. B. T.; Tam, K. L.; Watowich, M. M.; Solhaimi bin Fadzil, K.; Nicholas, C.; bin Mohd Sayed, I.; Seong Ng, K.; A L Lim, Y.; Venkataraman, V. V.; Wallace, I. J.; Kraft, T. S.; Lea, A. J.
10.1101/2025.06.06.658350 — evolutionary biology — Posted on 2025-06-10
2740 Alveolar epithelial cell plasticity and injury memory in human pulmonary fibrosis
Adams, T. S.; Schupp, J. C.; Balayev, A.; Khoury, J.; Justet, A.; Nikola, F.; Laurens, D. S. J.; Garcia, J. C.; Zapata-Ortega, M.; Panayiotis, B. V.; McDonough, J. E.; Ahangari, F.; Koenigshoff, M.; Ding, J.; Homer, R. J.; Rosas, I. O.; Yan, X.; Vanaudenaerde, B. M.; Wuyts, W. A.; Kaminski, N.
10.1101/2025.06.10.658504 — cell biology — Posted on 2025-06-10
2741 APOBEC3A deaminase catalyzes site-specific editing of transfer RNAs
Hoffa-Sobiech, K.; Sikora, J.; Ruszkowski, M.; Starczak, M.; Gackowski, D.; Blaszczak, A.; Mierzwa, A.; Rakoczy, M.; Marcinkowska-Swojak, M.; Stolarek, I.; Jackowiak, P.; Figlerowicz, M.; Budzko, L.
10.1101/2025.06.10.658825 — molecular biology — Posted on 2025-06-10
2742 Exapted CRISPR-Cas12f homologs drive RNA-guided transcription
Hoffmann, F. T.; Wiegand, T.; Palmieri, A. I.; Glass-Klaiber, J.; Xiao, R.; Tang, S.; Le, H.; Meers, C.; Lampe, G. D.; Chang, L.; Sternberg, S. H.
10.1101/2025.06.10.658865 — molecular biology — Posted on 2025-06-10
2743 The unique molecular recognition features of Siglec-10: structural insights into sialoglycan and antibody interactions
Sobczak, K.; Antonana-Vildosola, A.; Valverde, P.; Travecedo, M. A.; Jame-Chernaboo, Z.; Schmidt, E. N.; DAndrea, S.; Valdaliso-Diez, E.; Oyenarte, I.; Laugieri, M. E.; Joe, M.; Mozaneh, F.; Lin, S.-Y.; Bosch, A.; Moure, M. J.; Franconetti, A.; Lee, S. Y.; Etxaniz-Diaz de Durana, J.; Perez-Gutierrez, L.; Palazon, A.; Marcelo, F.; Fadda, E.; Corzana, F.; Gimeno, A.; Macauley, M. S.; Jimenez-Barbero, J.; Ereno-Orbea, J.
10.1101/2025.06.10.658867 — molecular biology — Posted on 2025-06-10
2744 A male-drive female-sterile system for the self-limited control of the malaria mosquito Anopheles gambiae
Bernardini, F.; Strampelli, A.; Willis, K.; Gulliford, H. R.; Gribble, M.; Fasulo, B.; Burt, A.; Crisanti, A.
10.1101/2025.06.10.658817 — molecular biology — Posted on 2025-06-10
2746 Salmonella hijacks a host glucose transporter for intravacuolar proliferation
Fang, X.; Shi, L.; Ding, Y.; Wang, Y.; Chen, W.; Xue, J.; Wang, L.; Hui, Y.; Tao, X.; Yang, J.; Du, L.; Xie, D.; Meng, K.
10.1101/2025.06.10.658782 — microbiology — Posted on 2025-06-10
2748 Light-harvesting by antenna-containing xanthorhodopsin from an Antarctic cyanobacterium
Marin Perez, M. d. C.; Murakoshi, S.; Rozenberg, A.; Tanaka, T.; Konno, M.; Shihoya, W.; Nureki, O.; Inoue, K.; Beja, O.
10.1101/2025.06.10.658827 — microbiology — Posted on 2025-06-10
2749 Plastic-Degrading Clusters of Orthologous Groups in Prokaryotes
Mustari, S.; Pham, L. T.; Saikkonen, K.; Nakamura, M.; Puigbo, P.
10.1101/2025.06.10.658834 — microbiology — Posted on 2025-06-10
2751 Intelectin-2 is a broad-spectrum antimicrobial lectin
Dugan, A. E.; Syangtan, D.; Nonnecke, E. B.; Chorghade, R. S.; Peiffer, A. L.; Yao, J. J.; Ille-Bunn, J.; Sergio, D.; Pishchany, G.; Dhennezel, C.; Vlamakis, H.; Bae, S.; Johnson, S.; Ellis, C.; Ghosh, S.; Alty, J. W.; Barnes, C. E.; Krupkin, M.; Carcamo-Oyarce, G.; Ribbeck, K.; Xavier, R. j.; Bevins, C. L.; Kiessling, L. L.
10.1101/2025.06.09.658748 — microbiology — Posted on 2025-06-10
2752 The DanRI regulatory system in uropathogenic Escherichia coli subverts neutrophil responses
Cerina, D.; Rousseau, M.; Olaiz, C. H.; Marsman, G.; Zychlinsky, A.; Ingersoll, M. A.
10.1101/2025.06.10.658900 — microbiology — Posted on 2025-06-10
2755 4-Nitrobenzoate inhibits 4-hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy
Verdaguer, I. B.; Santos, M. F.; Mazzine Filho, M.; Castro, G. O.; Hernandez, A.; Peres, M. A.; Katzin, A. M.; Crispim, M.
10.1101/2025.06.10.658244 — microbiology — Posted on 2025-06-10
2756 Impaired envelope integrity in the absence of SanA is linked to increased Lipid II availability and an imbalance of FtsI and FtsW activities
Carr, J. F.; De Santiago, C. B.; Bhut, S.; Warzecha, D. J.; Wei, R.; Herrera, C.; Trent, M. S.; Nan, B.; Mitchell, A.
10.1101/2025.06.10.658892 — microbiology — Posted on 2025-06-10
2757 Proposal of two new genera and seventy-seven new species of ascomycetous yeasts isolated from China
Zhu, H.-H.; Li, A.-H.; Liu, M.-M.; Jiang, Y.-L.; Zhao, X.-M.; Pan, S.; Liu, J.-H.; Zhang, X.-H.; Wang, J.-C.; Tian, Z.-Y.; Wang, G.-S.; Guo, Y.-T.; Phurbu, D.; Bai, F.-Y.; Wang, Q.-M.
10.1101/2025.06.10.658801 — microbiology — Posted on 2025-06-10
2759 Ionic Mechanisms Underlying Bistability in Spinal Motoneurons: Insights from a Computational Model
Molkov, Y.; Krust, F.; Jeter, R.; Stell, T.; Mohammed, M. A. Y.; Brocard, F.; Rybak, I.
10.1101/2025.06.06.658369 — neuroscience — Posted on 2025-06-10
2760 Dual effect of alpha-synuclein disease variants on condensate formation
Chandran, A.; Agarwal, A.; Wang, T.; Amaral, L.; Chaves, S. R.; Outeiro, T. F.; Lautenschlager, J.
10.1101/2025.06.06.657340 — neuroscience — Posted on 2025-06-10
2761 Voluntary movement initiation is associated with cardiac input in Libet's task.
Germanova, K.; Studenova, A.; Bredikhin, D.; Gippert, M.; Kapralov, N.; Klucharev, V.; Villringer, A.; Herrojo Ruiz, M.; Nikulin, V.
10.1101/2025.06.06.658322 — neuroscience — Posted on 2025-06-10
2765 Topological stratification of continuous genetic variation in large biobanks
Diaz-Papkovich, A.; Zabad, S.; Ben-Eghan, C.; Anderson-Trocme, L.; Femerling, G.; Nathan, V.; Patel, J.; Gravel, S.
10.1101/2023.07.06.548007 — genomics — Posted on 2025-06-10
2766 Subclonal mutation load predicts survival and response to immunotherapy in cancers with low to moderate tumor mutation burden
Jiang, Y.; Montierth, M. D.; Yu, K.; Ji, S.; Tran, Q.; Liu, X.; Shen, J. P.; Guo, S.; Wu, A.; Dai, Y.; Shin, S. J.; Li, R.; Cao, S.; Tang, Y.; Lesluyes, T.; Kopetz, S.; Msaouel, P.; Sood, A. K.; Devonshire, G.; Jones, C. M.; Ajani, J.; Subudhi, S. K.; Aparicio, A.; Sharma, P.; Shen, J. P.; Kimmel, M.; Wang, J. R.; Tarabichi, M.; Fitzgerald, R. C.; Zhu, H.; Loo, P. V.; Wang, W.
10.1101/2024.07.03.601939 — genomics — Posted on 2025-06-10
2767 Warning signals for the long-term innovative potential of genetic research based on 20 million papers and patents
Chae, J.; Kim, W.; Jung, W.; Jeong, D.; Lim, R.; Chamlagain, M.; Jung, G.; Jang, J.; Lee, J. W.; Kang, N. K.; Baek, K.; Shin, J.; Lee, Y.-G.; Koh, H. G.; Kim, C.; Yook, S.; Cheung, A. K. L.; Jin, Y.-S.; Youn, H.; Kim, P.-J.; Ghim, C.-M.
10.1101/2025.02.17.638429 — scientific communication and education — Posted on 2025-06-10
2769 The architecture of resilience: a genome assembly of Myrothamnus flabellifolia sheds light on desiccation tolerance and sex determination
Marks, R. A.; Lovell, J. T.; Carey, S. B.; Van Der Pas, L.; Chimukuche, N. M.; Bruna, T.; Plott, C.; Webber, J.; Lipzen, A.; Yan, J.; Bauer, D.; Bentley, J.; Talag, J.; Barry, K.; Grimwood, J.; Jenkins, J. W.; Schmutz, J.; Harkess, A.; VanBuren, R.; Leebens-Mack, J.; Farrant, J. M.
10.1101/2025.06.02.657439 — plant biology — Posted on 2025-06-10
2770 Defense-Suppressive Fragments of RIN4 generated by AvrRpt2 Participate in NDR1-dependent Activation of RPS2
Afzal, A. J.; Alam, M.; Huang, J.; Agha, M.; Da Cunha, L.; Iqbal Rai, M.; Tahir, J.; Jamroze, A.; Jones, J. D.; Mackey, D.
10.1101/2025.06.02.656948 — plant biology — Posted on 2025-06-10
2771 Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism
Godfrey, W. H.; Lee, J. J.; Shanmukha, S.; Cho, K.; Deng, X.; Ambati, C. S. R.; Putluri, V.; Kamal, A. H. M.; Kim, P. M.; Putluri, N.; Kornberg, M. D.
10.1101/2024.06.23.600101 — immunology — Posted on 2025-06-10
2773 Synaptic vesicles that store monoamines and glutamate differ in protein composition.
Asmerian, H.; Diaz, A. J.; Xu, H.; Oses-Prieto, J. A.; Alberts, J.; Sanetra, A. M.; Gnanabharathi, B.; Carr, N.; Burlingame, A. L.; Edwards, R. H.; Silm, K.
10.1101/2025.05.06.651945 — neuroscience — Posted on 2025-06-10
2774 Ras-dependent activation of BMAL2 regulates hypoxic metabolism in pancreatic cancer
Curiel-Garcia, A.; Holmstrom, S.; Castillo, C.; Palermo, C. F.; Sastra, S. A.; Andren, A.; Tomassoni, L.; Li, Z.; LeLarge, T.; Sagalovskiy, I.; Ross, D. R.; Wong, W.; Shaw, K.; Genkinger, J.; Hibshoosh, H.; Manji, G. A.; Iuga, A.; Schmid, R. M.; Johnson, K.; Badgley, M. A.; Laise, P.; Lyssiotis, C.; Shah, Y. M.; Califano, A.; Maurer, H. C.; Olive, K. P.
10.1101/2023.03.19.533333 — cancer biology — Posted on 2025-06-10
2781 Linking biotic interactions to species stability
Lajaaiti, I.; Kefi, S.; Loreau, M.; Ardichvili, A.; Arnoldi, J.-F.
10.1101/2025.03.25.645234 — ecology — Posted on 2025-06-10
2782 Growth and patterning in vertebrate limb developmentA timescale perspective on skeletal specification
Ben Tahar, S.; Comellas, E.; Duerr, T. J.; Bakr, D.; Monaghan, J. R.; Munoz, J. J.; Shefelbine, S. J.
10.1101/2025.03.20.644440 — developmental biology — Posted on 2025-06-10
2784 Unraveling Regulatory Feedback Mechanisms in Adult Neurogenesis Through Mathematical Modelling
Danciu, D.-P.; Klawe, F. Z.; Kazarnikov, A.; Femmer, L.; Kostina, E.; Martin-Villalba, A.; Marciniak-Czochra, A.
10.1101/2025.03.12.642763 — systems biology — Posted on 2025-06-10
2785 Tick extracellular vesicles alter keratinocyte function in the skin epidermis
Marnin, L.; Valencia, L.; Bogale, H.; Laukaitis-Yousey, H.; Rolandelli, A.; Ferraz, C. R.; O'Neal, A. J.; Schmitter-Sanchez, A.; Bencosme Cuevas, E.; Nguyen, T.-T.; Leal-Galvan, B.; Rickert, D. M.; Mendes, M. T.; Samaddar, S.; Butler, L. R.; Singh, N.; Cabrera Paz, F.; Wu-Chuang, A.; Oliver, J.; Jameson, J.; Munderloh, U.; Oliva Chavez, A.; Mulenga, A.; Park, S.; Serre, D.; Pedra, J. H. F.
10.1101/2023.11.10.566612 — microbiology — Posted on 2025-06-10
2786 Effects of diffusion MRI spatial resolution on human brain short-range association fiber reconstruction and structural connectivity estimation
Zheng, J.; Li, Z.; Zhong, W.; Wang, Z.; Li, Z.; Yang, H.; Liu, M.; Cao, X.; Liao, C.; Salat, D. H.; Huang, S. Y.; Tian, Q.
10.1101/2025.06.04.657810 — neuroscience — Posted on 2025-06-10
2791 Antimicrobial stewardship in animal health: experience-based co-design framework to capture progress and accelerate improvement
Hewson, K. A.; Binet, M.; Richards, K.; Gleeson, B.; Adsett, S.; Tuckett, G.; Kennedy, B.; Jenner, R.; Courtice, J.; Batterham, T.; Page, S. W.; Britton, S.
10.1101/2025.06.03.657743 — microbiology — Posted on 2025-06-10
2795 The phonology of sperm whale coda vowels
Begus, G.; Dabkowski, M.; Sprouse, R.; Gruber, D.; Gero, S.
10.1101/2025.06.09.658556 — animal behavior and cognition — Posted on 2025-06-10
2799 Optimizing a Human Monoclonal Antibody for Better Neutralization of SARS-CoV-2
Wang, Q.; Guo, Y.; Casner, R. G.; Yu, J.; Nair, M. S.; Ho, J.; Reddem, E. R.; Mellis, I. A.; Wu, M.; Tzang, C. C.; Hong, H.; Huang, Y.; Shapiro, L.; Liu, L.; Ho, D. D.
10.1101/2024.12.04.626800 — microbiology — Posted on 2025-06-10
2801 All spectral frequencies of neural activity reveal semantic representation in the human anterior ventral temporal cortex
Frisby, S. L.; Halai, A. D.; Cox, C. R.; Clarke, A.; Shimotake, A.; Kikuchi, T.; Kuneida, T.; Arakawa, Y.; Takahashi, R.; Ikeda, A.; Matsumoto, R.; Rogers, T. T.; Lambon Ralph, M. A.
10.1101/2025.04.17.649404 — neuroscience — Posted on 2025-06-10
2802 Hepatic retromer is essential for systemic cholesterol homeostasis by regulating lysosomal cholesterol metabolism
Vos, D. Y.; Barbosa, M. G.; Heida, A. H.; Caillaud, A.; Tissink, J. J.; Koster, M. H.; Smit, M.; Huijkman, N.; Kloosterhuis, N. J.; Girardeau, A.; Berue-Racape, Z.; Bloks, V. W.; Havinga, R.; Fuh, M. M.; Reggiori, F.; Mari, M.; Scheja, L.; Heeren, J.; Kuipers, F.; de Boer, J. F.; Rimbert, A.; Wolters, J. C.; Kuivenhoven, J. A.; Verzijl, C.; van de Sluis, B.
10.1101/2023.08.09.552611 — molecular biology — Posted on 2025-06-10
2806 Neural crest induction requires SALL4-mediated BAF recruitment to lineage specific enhancers
Demurtas, M.; Barnada, S. M.; Van Domeslaar, E.; Mitchell, Z. H.; Deelen, L. L.; Trizzino, M.
10.1101/2025.06.10.658805 — developmental biology — Posted on 2025-06-10
2809 Layer 6 is a hub for cholinergic modulation in the mouse auditory cortex
Vattino, L. G.; Clayton, K. K.; Hackett, T. A.; Takesian, A. E.; Polley, D. B.
10.1101/2025.06.09.658740 — neuroscience — Posted on 2025-06-10
2810 FOXP1 differentially regulates the development of murine vasopressin and oxytocin magnocellular neurons
Berkhout, J.; Trender, S.; Krabichler, Q.; Podpecan, Y.; Franke, F.; Schubert, T.; Burbach, P.; Grinevich, V.; Adan, R.; Fröhlich, H.; Althammer, F.; Meijer, O.; Mahfouz, A.
10.1101/2025.06.10.658830 — neuroscience — Posted on 2025-06-10
2814 Acute anaphylactic and multiorgan inflammatory effects of Comirnaty in pigs: evidence of spike protein mRNA transfection and paralleling inflammatory cytokine upregulation
Dezsi, L.; Kokeny, G.; Szeneasi, G.; Revesz, C.; Meszaros, T.; Barta, B.; Facsko, R.; Szilasi, A.; Bakos, T.; Kozma, G. T.; Dobos, A.; Merkely, B.; Radovits, T.; Szebeni, J.
10.1101/2025.06.07.658379 — immunology — Posted on 2025-06-10
2816 Hyperpolarization activated cation channel mediated intrinsic plasticity changes underlie the malleability of with-in cell-type electrophysiological heterogeneity
Chameh, H. M.; Falby, M.; Yang, Y.; Movahed, M.; Arbabi, K.; Sarathy, C.; Tripathy, S. J.; Zhang, L.; Lefebvre, J.; Valiante, T. A.
10.1101/2025.06.09.658517 — neuroscience — Posted on 2025-06-10
2820 The Desmoglein 2 interactome in primary neonatal cardiomyocytes
Li, Y.; Campbell, A. P.; Balasubramanian, S.; Zeng, X.; Porter, E.; Cantrell, P. S.; Sun, M.; Mattheyses, A. L.; Kwiatkowski, A. V.
10.1101/2025.06.09.658637 — cell biology — Posted on 2025-06-10
2822 Electron tomography reveals mitochondrial network and cristae remodelling during cell differentiation in the human placenta
Acharya, S.; Hanssen, E.; Botha, V. B.; Smith, T. M.; Jayatissa, S.; Trifunovic, Z.; Bartho, L. A.; Schjenken, J. E.; Kaitu'u-Lino, T. J.; Perkins, A. V.; James, J. L.; Pringle, K. G.; Bouwer, J. C.; Smith, R.; Fisher, J. J.
10.1101/2025.06.09.658204 — cell biology — Posted on 2025-06-10
2823 Neuronal migration induces DNA damage in developing brain
Zhang, Z.; Canela, A.; Zou, P.; Furuta, T.; Takeda, N.; Kawaue, T.; Nakazawa, N.; Saeki, M.; Utsunomiya, M.; Kurisu, J.; Ishidate, F.; Sasanuma, H.; Kishi, Y.; Kengaku, M.
10.1101/2025.06.10.658810 — cell biology — Posted on 2025-06-10
2829 Volumetric single-molecule tracking inside subcellular structures
Daly, S.; Chambers, J. E.; Jones, C.; Fu, B.; Manton, J. D.; Beckwith, J. S.; Marciniak, S. J.; Gershlick, D. C.; Lee, S. F.
10.1101/2025.06.09.658280 — biophysics — Posted on 2025-06-10
2830 Secondary structure transitions and dual PIP2 binding define cardiac KCNQ1-KCNE1 channel gating
Zhong, L.; Lin, X.; Cheng, X.; Wan, S.; Hua, Y.; Nan, W.; Hu, B.; Yan, Z.; Jiang, D.; Zhang, H.; Liu, F.; Xiao, C.; Zhou, Z.; Yu, H.; Ma, L.; Huang, C.; Wong, K. W.; Chung, S. K.; Shen, B.; Jiang, Z.-H.; Neher, E.; Zhu, W.; Zhang, J.; Hou, P.
10.1101/2025.06.10.657059 — biophysics — Posted on 2025-06-10
2831 Phosphorylation Toggles the SARS-CoV-2 Nucleocapsid Protein Between Two Membrane-Associated Condensate States
Favetta, B.; Wang, H.; Cubuk, J.; Singh, A.; Barai, M.; Ramirez, C.; Gormley, A. J.; Murthy, S.; Dignon, G.; Soranno, A.; Shi, Z.; Schuster, B. S.
10.1101/2024.10.17.618867 — biophysics — Posted on 2025-06-10
2833 Large adipocytes in a biomimetic adipose tissue model promote breast cancer malignancy
Beeghly, G. F.; Pincus, M. I.; Varshney, R. R.; Giri, D. D.; Falcone, D. J.; Rudolph, M. C.; Antonyak, M. A.; Iyengar, N. M.; Fischbach, C.
10.1101/2025.03.28.645549 — bioengineering — Posted on 2025-06-10
2844 Pcbp1 orchestrates amino acid metabolism burst during the naive-to-primed pluripotency transition
Bakhmet, E. I.; Potapenko, E. V.; Shuvalov, O. Y.; Lobov, A. A.; Repkin, E. A.; Vorobyeva, N. E.; Korablev, A. N.; Zinovyeva, A. S.; Kuzmin, A. A.; Aksenov, N. D.; Kopylov, A. T.; Wu, G.; Schoeler, H. R.; Tomilin, A. N.
10.1101/2025.06.07.658314 — developmental biology — Posted on 2025-06-10
2845 Developmental Emergence of Replay-DMN Coordination Predicts Entorhinal Grid Codes
Pang, L.; Qu, Y.; Ou, J.; Wu, S.; Luo, Y.; Gohil, C.; Woolrich, M.; Behrens, T.; Liu, Y.
10.1101/2025.04.02.646732 — neuroscience — Posted on 2025-06-10
2846 FRA1 drives melanoma metastasis through an actionable transcriptional network
Xu, X.; Chadourne, M.; Soto-Vargas, Z.; Jarajapu, V.; Yao, J.; Yu, X.; Karreth, F. A.
10.1101/2025.06.07.658418 — cancer biology — Posted on 2025-06-10
2847 Treatment Resistant Persister Cells Exploit Macrophage Lipid Metabolism to Sustain Glioblastoma Growth
Chakraborty, A.; Yang, C.; Silver, A.; Feier, D.; Tian, G.; Pittu, A.; Roemeling, C. V.; Thomas, N.; Andrews, M.; Conforti, C.; Sobanjo, O. O.; Searl, N. T.; Anica, M. N.; McTiernan, R.; Rahman, M.; Huang, J.; Harrison, J. K.; Mitchell, D. A.; Sarkisian, M.; Deleyrolle, L. P.
10.1101/2025.06.07.658345 — cancer biology — Posted on 2025-06-10
2848 Cut-Detector: A Tool for Automated Temporal Analysis of Late Cytokinetic Events
Bonte, T.; Dubois, L.; Gagna, P.; Dibsy, R.; Petrovic, A.; Advedissian, T.; Serres, M.; Cuvelier, F.; Crouigneau, M.; Sassoon, N.; Gupta-Rossi, N.; Fremont, S.; Echard, A.; Walter, T.
10.1101/2025.06.06.658046 — bioinformatics — Posted on 2025-06-10
2849 Decoding PDI diversity: insights into structure, domains, and functionality in sorghum
Lopez Gomez, C. F.; Morris, M. T.; Massel, K.; Smith, M.; Crisp, P.; Schenk, G.; Godwin, I. D.
10.1101/2025.06.06.658324 — bioinformatics — Posted on 2025-06-10
2851 Monalisa: An Open Source, Documented, User-Friendly MATLAB Toolbox for Magnetic Resonance Imaging Reconstruction
Leidi, M.; Jia, Y.; Helbing, D.; Barranco, J.; Acikgoz, B. C.; Peper, E.; Ledoux, J.-B.; Bastiaansen, J. A. M.; Franceschiello, B.; Milani, B.
10.1101/2025.06.06.658299 — bioinformatics — Posted on 2025-06-10
2852 Female Moths Incorporate Plant Acoustic Emissions into Their Oviposition Decision
Seltzer, R.; Zer Eshel, G.; Yinon, O.; Hafani, A.; Eitan, O.; Matveev, S.; Levedev, G.; Davidovitz, M.; Ben Tov, T.; Sharabi, G.; Shapira, Y.; Shvil, N.; Atallah, I.; Hadad, S.; Ment, D.; Hadany, L.; Yovel, Y.
10.1101/2024.11.06.622209 — animal behavior and cognition — Posted on 2025-06-10
2853 The Population Genetics of Biological Noise
Weinreich, D. M.; Sgouros, T.; Raynes, Y.; Burtsev, H.; Chang, E.; Rajakumar, S.; Bravo, I. G.; Petak, C.
10.1101/2025.01.11.632402 — evolutionary biology — Posted on 2025-06-10
2856 Harnessing Random Peptide Mixtures to Overcome Multidrug-Resistant Fungal Infections
Adeoye, J.; Belo, Y.; Rocha, M.; Hayby, H.; Israyilova, A.; Hayouka, Z.; Shlezinger, N.
10.1101/2024.09.01.610663 — microbiology — Posted on 2025-06-10
2859 Extracting Reproducible Components from Electroencephalographic Responses to Transcranial Magnetic Stimulation with Group Task-Related Component Analysis
Couto, B. A. N.; Fecchio, M.; Russo, S.; De Martino, E.; Parmigiani, S.; Sarasso, S.; Graven-Nielsen, T.; de Andrade, D. C.; Massimini, M.; Rosanova, M.; Casali, A. G.
10.1101/2025.06.02.657489 — neuroscience — Posted on 2025-06-10
2864 Rapid transcriptional response to a dynamic morphogen by time integration
Brantley, S. E.; Janssen, J.; Chao, A.; Vergassola, M.; Blythe, S. A.; Di Talia, S.
10.1101/2025.06.09.658715 — developmental biology — Posted on 2025-06-09
2867 Convergent and divergent brain-cognition relationships during development revealed by cross-sectional and longitudinal analyses in the ABCD Study
Xie, Y.; Zhang, S.; Orban, C.; Ooi, L. Q. R.; Kong, R.; Floris, D. L.; Zuo, X.-N.; Dhamala, E.; Holmes, A. J.; Uddin, L. Q.; Nichols, T. E.; Di Martino, A.; Yeo, B. T. T.
10.1101/2025.06.06.658294 — neuroscience — Posted on 2025-06-09
2875 AAV gene therapy for Cockayne syndrome
Batista, A. R.; Scholand, A. C.; Callahan, W. S.; Watson, M. K.; Sion, C. M.; Mola, T.; O'Hara, K.; King, O. D.; King, R. M.; Sena-Esteves, M.
10.1101/2025.06.06.658349 — neuroscience — Posted on 2025-06-09
2876 The Vitis vinifera receptor VvLYK6 negatively regulates chitin-triggered immune responses and promotes fungal infections
VILLETTE, J.; MARZARI, T.; LANDRY, D.; ROUDAIRE, T.; ROMANET, R.; KLINGUER, A.; LEBORGNE-CASTEL, N.; VICEDO, C.; GASCIOLLI, V.; POUZET, C.; LEFEBVRE, B.; HELOIR, M. C.; POINSSOT, B.
10.1101/2025.06.06.658283 — plant biology — Posted on 2025-06-09
2885 Monitoring for fisheries or for fish? Declines in monitoring of salmon spawners continue despite a conservation crisis
Atkinson, E. M.; Carturan, B. S.; Atkinson, C. P.; Bateman, A. W.; Connors, K.; Hertz, E.; Peacock, S. J.
10.1101/2024.12.01.626233 — ecology — Posted on 2025-06-09
2889 Formins and Arp2/3 Reciprocally Regulate Contact Guidance on Aligned Collagen Fibrils
Foroozandehfar, A.; Tohidi, S.; Siddiqui, S. A.; Namanda, F. R.; Forrester, M.; Cochran, E.; Schneider, I.
10.1101/2025.01.03.631234 — bioengineering — Posted on 2025-06-09
2890 A Slc5a6 Deficient Mouse Model Reveals a Metabolically Driven Dilated Cardiomyopathy with Therapeutic Potential for Vitamin-Based Intervention
Fullerton, M. O.; Phillips, L. C.; Redgrave, R. E.; Haufroid, V.; Merces, G.; Kerridge, S. T.; Richardson, G. D.; Mercier, N.; Roland, D.; Dewulf, J. P.; Burn, J.; Bamforth, S. D.; Phillips, H. M.
10.1101/2025.06.06.658273 — genetics — Posted on 2025-06-09
2892 Chromosome-length genome assembly of Uta stansburiana and gene expression data reveal fast pace-of-life comes with environmental stability
Fellows, S.; Araya-Donoso, R.; Davalos-Dehullu, E.; Khan, R.; Weisz, D.; Dudchenko, O.; Aiden, E. L.; Munguia-Vega, A.; Dolby, G. A.; Edwards, D. L.
10.1101/2025.05.28.656178 — evolutionary biology — Posted on 2025-06-09
2893 Caudata macrogenetics: Geographic attributes predict mitochondrial genetic variation in salamanders on a global scale
Amador, L.; Wiley, D. L. F.; Arroyo-Torres, I.; McDaniels, C. X.; Rosario-Sanchez, E. O.; Farmer, H.; Bradley, H.; Erdmann, J.; Pelletier, T. A.; Barrow, L. N.
10.1101/2025.01.24.634750 — evolutionary biology — Posted on 2025-06-09
2895 Metacaspases mediate thermotolerance of diatoms following marine heat waves
Sadeh, M.; Schatz, D.; Ben-Dor, S.; Mizrachi, A.; Graff van Creveld, S.; Zafrin, A.; Vardi, A.
10.1101/2025.06.09.658587 — microbiology — Posted on 2025-06-09
2896 Analysis of Essential Genes in Clostridioides difficile by CRISPRi and Tn-seq
Alberts, M. E.; Kurtz, M. P.; Müh, U.; Bernardi, J. P.; Bollinger, K. W.; Duncan, L.; Dobrila, H. A.; Laster, H. M.; Orea, A. J.; Pannullo, A. G.; Rivera-Rosado, J. G.; Torres, F. V.; Ellermeier, C. D.; Weiss, D. S.
10.1101/2025.06.04.657922 — microbiology — Posted on 2025-06-09
2897 Zα domain-dependent ZBP1 condensate formation induces an amyloidal necroptotic signalling complex
Nemegeer, J.; Soenmez, A.; Dierick, E.; Staes, K.; Naesens, L.; Vandenabeele, P.; Lafontaine, D. L.; Maelfait, J.
10.1101/2025.06.06.658343 — immunology — Posted on 2025-06-09
2899 Enteric nervous system degeneration in human and murine CLN3 disease, is ameliorated by gene therapy in mice
Ziolkowska, E. A.; Williams, L. L.; Jansen, M. J.; Wang, S. H.; Eultgen, E. M.; Sharma, J.; Sardiello, M.; Bradley, R. P.; Whiteman, I. T.; Sands, M. S.; Heuckeroth, R. O.; Cooper, J. D.
10.1101/2025.01.29.635518 — neuroscience — Posted on 2025-06-09
2900 Endothelin B receptor inhibition rescues aging-dependent neuronal regenerative decline
Feng, R.; Rosen, S. F.; Ansari, I.; John, S.; Thomsen, M. B.; Avraham, O.; Geoffroy, C. G.; Cavalli, V.
10.1101/2024.06.08.597928 — neuroscience — Posted on 2025-06-09
2903 Single Cell Spatial Profiling Identifies Region-Specific Extracellular Matrix Adhesion and Signaling Networks in Glioblastoma
De, A.; Forero, S. A.; Pirani, A.; Morales, J. E.; De La Fuente-Granada, M.; Sebastian, S.; Huse, J. T.; Ballester, L. Y.; Weinberg, J. S.; Lang, F. F.; Akdemir, K. C.; McCarty, J. H.
10.1101/2024.10.31.621280 — cancer biology — Posted on 2025-06-09
2906 Bacterial extracellular vesicles as a tunable platform for vaginal drug delivery
Steinman, D.; Hemanth, V.; McIlvaine, R.; Tyagi, P.; Kang, H.; Alam, R.; Liu, A.; Jewell, C.; Burd, I.; Molinari, S.; Zierden, H.
10.1101/2025.06.09.658669 — bioengineering — Posted on 2025-06-09
2907 CalciumInsights: An Open-Source, Tissue-Agnostic Graphical Interface for High-Quality Analysis of Calcium Signals
Gomez, D. S.; Rosas, N. C. P.; Contreras, G. I. M.; Brana, S. R. C.; Zhang, W.; Mim, M. S.; Tan, S. G.; Gazzo, D.; Tepole, A. B.; Deng, Q.; Reeves, G. T.; Isaza, C. E.; Staiger, C. J.; Umulis, D. M.; Zartman, J. J.; Rios, M. C.
10.1101/2025.06.04.657923 — bioengineering — Posted on 2025-06-09
2911 Loss of nephronophthisis-associated nephrocystin-1 impairs DNA damage repair in kidney organoids
Sendino Garvi, E.; Biermans, S.; Knoers, N. N. V. A. M.; van Eerde, A. A. M.; Masereeuw, R.; Slaats, G. G. G.; van Genderen, A. M.; Janssen, M. J.
10.1101/2025.06.09.658557 — molecular biology — Posted on 2025-06-09
2912 DDX3X acts as a selective dual switch regulator of mRNA translation in acute ER stress
Shawky, A.-E.-M. A.; Scarboro, A.; Mick, J.; Dondeti, M.; Avanzino, K.; Simintiras, C.; Hatzoglou, M.; Vourekas, A.
10.1101/2025.06.08.658532 — molecular biology — Posted on 2025-06-09
2913 Acute induction of IFNα is responsible for the attenuation of the live measles vaccine
Edwards, J.; Yoon, S.; Brockhurst, J. K.; Rennick, L. J.; Duprex, W. P.; Coppens, I.; Pekosz, A.; Griffin, D. E.
10.1101/2025.06.09.658652 — microbiology — Posted on 2025-06-09
2916 Prenatal Zika Virus Exposure Disrupts Social-Emotional Development and Cortical Visual Function in Infant Macaques
Ausderau, K. K.; Boerigter, B.; Razo, E. R.; Gutkes, J.; Krabbe, N. P.; Mitzey, A. M.; Walsh, S.; Menna, V.; Drew, J. R.; Kabakov, S.; Eckes, F.; Spanton, R. V.; Shah, A.; Sun, A.; Katz, A.; Kim, C.; Hartman, A.; Weiler, A. M.; Rasmussen, C.; Nork, M.; Basu, P.; Simmons, H. A.; Ver Hoeve, J.; Capuano, S.; Friedrich, T. C.; Mohr, E. L.
10.1101/2025.06.09.658678 — microbiology — Posted on 2025-06-09
2918 Plasticity in a bacterial global regulatory switch that drives a shift in antibiotic resistance and virulence
Correia, A.; Manners, E. J.; Evans, B. A.; Malone, J. G.; O'Grady, J.; Mavrogiorgou, E.; Arminu, S.; Usai, M.; Naik, D.; McMillan, S.; Kay, G. L.; Hill, C.; Sudhakar, P.; Meader, E.; Schmidt, K.; Korcsmaros, T.; Desbois, A. P.; Crossman, L.; Wain, J.; Langridge, G. C.
10.1101/2025.06.09.658697 — microbiology — Posted on 2025-06-09
2921 Identification of reactive CpGs and RNA expression in early COVID-19 through cis-eQTM analysis reflecting disease severity and recovery
Ryu, H.; An, K.; Kwon, Y.; Jeon, Y.; Jeon, S.; Choi, H.; Kim, Y. J.; Kim, S.; Sul, O. J.; Lee, S.; Chun, A. Y.; Shin, E.-S.; Ra, S. W.; Bhak, J.
10.1101/2025.06.09.658549 — bioinformatics — Posted on 2025-06-09
2922 High-throughput in vivo screening using barcoded mRNA identifies lipid nanoparticles with extrahepatic tropism for cancer immunotherapy
Hamilton, A. G.; Thatte, A. S.; Xu, J.; Luo, Z.; Safford, H. C.; Swingle, K. L.; Muscat-Rivera, J.; Kegel, M.; Han, X.; Joseph, R. A.; Murray, A. M.; Geisler, H. C.; Whitaker, R. C.; Xue, L.; Spektor, R.; Melamed, J. R.; Weissman, D.; Mitchell, M. J.
10.1101/2025.06.09.658602 — bioengineering — Posted on 2025-06-09
2923 Expression of a human Gb3/CD77 synthase in insect and human cells: comparison of activity and glycosylation
Mikolajczyk, K.; Szymczak-Kulus, K.; Bereznicka, A.; Kaczmarek, R.; Sobala, L. F.; Jakubiak-Augustyn, A.; Czerwinski, M.
10.1101/2025.06.09.658241 — biochemistry — Posted on 2025-06-09
2925 Methane-fed microbial communities enriched from field-grown rice support diverse heterotrophic bacteria
Perry, E. K.; Hasnain, A.; Cole, B. J.; Carlson, H. K.; Deutschbauer, A. M.; Chiniquy, D.
10.1101/2025.06.09.658666 — microbiology — Posted on 2025-06-09
2926 Brain FGF2 and NCAM1 contribute to FGFR1-dependent progression of ER+ breast cancer brain metastases in young and aged hosts
Fox, M. S.; Jaramillo-Gomez, J. A.; Marquez-Ortiz, R. A.; Alvarez-Eraso, K. L. F.; Contreras Zarate, M. J.; Koliavas, S.; Kabos, P.; Serkova, N. J.; Sartorius, C. A.; Wellberg, E. A.; Cittelly, D. M.
10.1101/2025.06.07.658373 — cancer biology — Posted on 2025-06-09
2927 Inflammasome activation differences underpin different Mycobacterium tuberculosis infection outcomes
Kumar, R.; Kolloli, A.; Bhargavi, G.; Husain, S.; Ghanny, S.; Soteropoulos, P.; Subbian, S.
10.1101/2025.06.06.658135 — immunology — Posted on 2025-06-09
2929 Improved Allele Frequencies in gnomAD through Local Ancestry Inference
Kore, P.; Wilson, M.; Tiao, G.; Chao, K. R.; Darnowsky, P. W.; Watts, N.; Honorato-Mauer, J.; Baxter, S. M.; Genome Aggregation Database Consortium, ; Rehm, H.; Daly, M.; Karczewski, K. J.; Atkinson, E. G.
10.1101/2024.10.30.620961 — genomics — Posted on 2025-06-09
2930 Failed Cellular Surveillance Enables Pathogenic Matrix Deposition in a COL2A1-Related Osteoarthritis
Yammine, K. M.; Abularach, S. M.; Kim, S.-y.; Bikovtseva, A. A.; Lilianty, J.; Butty, V. L.; Schiavoni, R. P.; Bateman, J. F.; Lamande, S. R.; Shoulders, M. D.
10.1101/2023.10.19.562780 — genetics — Posted on 2025-06-09
2932 Single-cell and cell-type-level insights into stress-driven immune regulation relevant to disease
Benavides, S.; Kosyk, O.; Carpenter, L.; Georgiou, C.; Miller, B. C.; Stanley, N.; Zannas, A. S.
10.1101/2025.06.05.658150 — immunology — Posted on 2025-06-09
2933 Imaging CRISPR-Edited CAR-T Cell Therapies with Optical and Positron Emission Tomography Reporters
Sanchez-Pupo, R. E.; Kelly, J. J.; Shalaby, N.; Xia, Y.; Martinez Santiesteban, F. M.; Lau, J.; Verriet, I.; Hicks, J.; Fox, M.; Thiessen, J. D.; Ronald, J. A.
10.1101/2025.06.06.658308 — immunology — Posted on 2025-06-09
2934 SINE compounds activate exportin-1 degradation via an allosteric mechanism
Wing, C. E.; Fung, H. Y. J.; Kwanten, B.; Cagatay, T.; Niesman, A. B.; Jacquemyn, M.; Gharghabi, M.; Permentier, B.; Shakya, B.; Nandi, R.; Ready, J. M.; Kashyap, T.; Shacham, S.; Landesman, Y.; Lapalombella, R.; Daelemans, D.; Chook, Y. M.
10.1101/2024.10.07.617049 — cancer biology — Posted on 2025-06-09
2936 ArchMap: A web-based platform for reference-based analysis of single-cell datasets
Lotfollahi, M.; Bright, C.; Skorobogat, R.; Dehkordi, M.; George, X.; Richter, S.; Topalova, A.; Shitov, V.; Luecken, M. D.; Theis, F. J.
10.1101/2024.09.19.613883 — bioinformatics — Posted on 2025-06-09
2937 A hybrid machine learning framework leveraging biophysicochemical insights for scalable discovery of protein-ligand interactions
Rayakar, A. A.; Jaladanki, C. K.; Ong, Q.; Tan, B.; Chen, J.; Tan, A. Q. L.; Lim, L. T. R.; Kohaal, N.; Chen, Y.; Wang, J.; Han, W.; Hu, J.; Lee, H. K.; Fan, H.
10.1101/2025.03.16.643501 — bioinformatics — Posted on 2025-06-09
2938 Brain-derived extracellular vesicle microRNAs in Lewy body and Alzheimer's disease
Yang, S. J.; Lin, A. A.; Shen, H.; Pappalardo, L. W.; Spychalski, G. B.; Rosario, J.; Forsberg, L. K.; Grant, K. M.; Savica, R.; O'Bryant, S.; Jones, D. T.; Dickson, D. W.; Reichard, R. R.; Nguyen, A. T.; Meaney, D. F.; Boeve, B. F.; Ross, O. A.; McLean, P. J.; Issadore, D.
10.1101/2025.06.06.656900 — bioengineering — Posted on 2025-06-09
2939 Low-density lipoprotein receptor-targeting chimeras for membrane protein degradation and enhanced drug delivery
Zhao, F.; Wu, Y.; Schaefer, K.; Zhang, Y.; Miao, K.; Yao, Z.; Ganjave, S. D.; Kumru, K.; Peters-Clarke, T. M.; Inague, A.; Olzmann, J. A.; Leung, K. K.; Wells, J. A.
10.1101/2025.06.06.658366 — bioengineering — Posted on 2025-06-09
2940 Combined Central and Peripheral Nerve Stimulation Improves Functional Recovery of Mixed Peripheral Nerve Injury in a Rat Forelimb Model
Eftekari, S. C.; Yoon, Y.-C.; Chen, R. C.-H.; Nicksic, P. J.; Donnelly, D. T.; Jesch, A.; Shaffrey, E. C.; Zeng, W.; Ludwig, K. A.; Poore, S. O.; Vakoc, B. J.; Suminski, A.; Dingle, A. M.
10.1101/2025.01.26.634922 — neuroscience — Posted on 2025-06-09
2943 MIRO1 controls energy production and proliferation of vascular smooth muscle cells
Qian, L.; Koval, O. M.; Endoni, B. T.; Juhr, D.; Stein, C. C.; Allamargot, C.; Lin, L.-H.; Guo, D.-F.; Rahmouni, K.; Boudreau, R. L.; Streeter, J.; Thiel, W. H.; Grumbach, I. M.
10.1101/2024.08.13.607854 — cell biology — Posted on 2025-06-09
2945 Single-cell and cell-type-level insights into stress-driven immune regulation relevant to disease
Benavides, S.; Kosyk, O.; Carpenter, L.; Georgiou, C.; Miller, B. C.; Stanley, N.; Zannas, A. S.
10.1101/2025.06.05.658150 — immunology — Posted on 2025-06-09
2946 Effects of diffusion MRI spatial resolution on human brain short-range association fiber reconstruction and structural connectivity estimation
Zheng, J.; Li, Z.; Zhong, W.; Wang, Z.; Li, Z.; Yang, H.; Liu, M.; Cao, X.; Liao, C.; David, S. H.; Huang, S. Y.; Tian, Q.
10.1101/2025.06.04.657810 — neuroscience — Posted on 2025-06-09
2947 Too little and too much: balanced hippocampal, but not medial prefrontal, neural activity is required for intact novel object recognition in rats
Taylor, C. J. L.; Renstrom, J. G.; Loayza, J.; Gwilt, M.; Williams, S. A.; Grasmeder Allen, R.; Moran, P. M.; Gigg, J.; Neill, J.; Harte, M.; Bast, T.
10.1101/2025.04.01.646403 — neuroscience — Posted on 2025-06-09
2951 Testing for a wildlife reservoir of divergent SARS-CoV-2 in white-tailed deer
Crawshaw, L.; Kotwa, J. D.; Jeeves, S. P.; Loomer, C.; Dibernardo, A.; Stewart, A.; Newar, S. L.; Chien, E.; Yim, W.; Kruczkiewicz, P.; Vernygora, O.; Lung, O.; Schulte-Hostedde, A. I.; Nituch, L.; Maguire, F.; Pickering, B.; Jardine, C. M.; Coatsworth, H.; Mubareka, S.; Bowman, J.
10.1101/2025.05.22.655348 — pathology — Posted on 2025-06-09
2952 Infrared Laser Sampling of Low Volumes Reveals Marker Lipids in Palatine Tonsil Carcinoma via Shotgun Lipidomics
Kerkhoff, L.; Moritz, M.; Eggert, D.; Worthmann, A.; Heeren, J.; Zech, H.; Clauditz, T.; Wilczak, W.; Schlueter, H.; Betz, C. S.; Bottcher, A.; Hahn, J.
10.1101/2025.06.05.658016 — cancer biology — Posted on 2025-06-09
2953 PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer
Young, A. A.; Juhler, I. G.; Pierce, J. R.; Bohlin, H. E.; Harper, H. A.; Onishile, D. S.; Chua, R. N.; Liu, M. E.; Gardner, E. N.; Elzey, B. D.; Cottrell, K. A.
10.1101/2025.05.27.656288 — cancer biology — Posted on 2025-06-09
2954 GTP cycling gates CTP synthase activation
Guo, C.-J.; Wu, Y.-F.; Guo, S.-Y.; Lu, J.-L.; Xu, L.; Fu, Y.; Zhou, X.; Zhong, J.; Wang, W.; Zhang, Z.; Liu, J.-L.
10.1101/2022.09.24.509316 — biochemistry — Posted on 2025-06-09
2955 A Cryptic Interfacial Pocket Uncovered in Full CRL4CRBN-IKZF3 Ubiquitylation Complex Enhances IMiD Efficacy
Deng, Z.; Ai, H.; Shi, Q.; Liang, J.; He, Z.; Zheng, J.; Li, H.; Zhang, L.; He, W.; Tao, S.; Zheng, Q.; He, W.; Pan, M.; Liu, L.
10.1101/2025.06.08.658527 — biochemistry — Posted on 2025-06-09
2957 Hb-EGF directs systemic muscle repair
Dean, H. C.; Saraswathy, V.; Saini, A.; Ou, T.; McAdow, J.; Tendolkar, A.; Mokalled, M.; Johnson, A. N.
10.1101/2025.06.04.657846 — developmental biology — Posted on 2025-06-09
2958 Remodelled cholesteryl ester enriched lipid droplets fuel flavivirus morphogenesis
Banducci-Karp, A.; Brixton, S.; Shah, P. M.; Li, M.-Y.; Bancroft, J.; Riepsaame, J.; Dhaliwal, R.; Melia, C. E.; Malavige, G. N.; Sanyal, S.
10.1101/2025.06.07.658178 — cell biology — Posted on 2025-06-09
2959 A Transient Increase in Cardiomyocyte Protein O-GlcNAcylation Enhances Susceptibility to Pressure Overload-Induced Cardiac Remodeling
Chang, S. F.; Ha, C.-M.; Brahma, M. K.; Potter, L. A.; Reddy, M. S.; Bakshi, S.; Preuss, K.; Rahman, M. S.; Fischer, J.; Harrell, C. A.; Sun, Z.; Chatham, J. C.; Wende, A. R.
10.1101/2025.06.04.657956 — molecular biology — Posted on 2025-06-09
2960 Accumulation of LRRK2-associated phospho-Rab12 degenerative lysosomes in tauopathies
Buck, S. A.; Malankhanova, T.; Ma, E. B.; Yim, S.; Pratt, H. W.; Ervin, J.; Wang, S.-H. J.; Cohen, T. J.; West, A. B.; Sanders, L. H.
10.1101/2025.06.06.658328 — neuroscience — Posted on 2025-06-09
2961 Smelling the Risk: Early Olfactory Deficits, Brain Networks, and Blood Markers of Alzheimers Disease Risk in Humanized APOE Mice
Moon, H. S.; Han, Z. Y.; Anderson, R. J.; Mahzarnia, A.; Stout, J. A.; Niculescu, A.; Tremblay, J.; Badea, A.
10.1101/2025.06.06.658383 — neuroscience — Posted on 2025-06-09
2963 Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of Fragile X syndrome.
Wang, H.-B.; Smale, N. E.; Brown, S. H.; Villanueva, S. A.; Zhou, D.; Mulji, A.; Bhandal, D. S.; Nguyen-Ngo, K.; Harvey, J. R.; Ghiani, C. A.; Colwell, C. S.
10.1101/2024.09.16.613343 — neuroscience — Posted on 2025-06-09
2965 A Chromosome-Level Assembly of the Pine Processionary Moth (Thaumetopoea pityocampa) genome
Gautier, M.; Nouhaud, P.; Lagnel, J.; Saune, L.; Legeai, F.; Parinello, H.; Gschloessl, B.; Marande, W.; Lopez-Roques, C.; Dorkeld, F.; Branco, M.; Perrier, C.; Kerdelhue, C.
10.1101/2025.06.06.658235 — genomics — Posted on 2025-06-09
2966 Multiparent Recombinant Inbred lines crossed to a tester provide novel insights into sources of cis and trans regulation of gene expression
Marroni, F.; Morse, A. M.; Nanni, A.; Nolte, N. F.; Williams-Simon, P.; Leon-Novelo, L. G.; Graze, R. M.; Schmidt, P.; King, E. G.; McIntyre, L. M.
10.1101/2025.06.07.658407 — genetics — Posted on 2025-06-09
2968 Uncovering Heterogeneous Effects via Localized Feature Selection
Liu, X.; Gu, J.; Chen, Z.; Chu, B.; Liu, L.; Morrison, T.; Butler, R. R.; Edelson, J.; Li, J.; Longo, F. M.; Tang, H.; Ionita-laza, I.; Sabatti, C.; Candes, E.; He, Z.
10.1101/2025.06.03.657761 — bioinformatics — Posted on 2025-06-09
2971 Localization of KANK2 to Focal or Fibrillar Adhesions Influences Migration in Melanoma Cell Lines
Stojanovic, N.; Rac, A.; Loncaric, M.; Tadijan, A.; Paradzik, M.; Acman, M.; Humphries, J. D.; Humphries, M. J.; Ambriovic-Ristov, A.
10.1101/2025.02.24.639831 — cell biology — Posted on 2025-06-09
2972 TURBO: Automated Total-body PET Image Processing and Kinetic Modeling Toolbox
Tuisku, J.; Palonen, S.; Kärpijoki, H.; Latva-Rasku, A.; Tuomola, N.; Harju, H.; Nesterov, S.; Oikonen, V.; Iida, H.; Teuho, J.; Han, C.; Karjalainen, T.; Kirjavainen, A. K.; Rajander, J.; Klen, R.; Nuutila, P.; Nummenmaa, L.; Knuuti, J.
10.1101/2025.06.06.658206 — neuroscience — Posted on 2025-06-09
2974 Identification and Validation of a Previously Missed Mutational Signature in Colorectal Cancer
Kazachkova, M.; Otlu-Saritas, B.; Diaz-Gay, M.; Abbasi, A.; Moody, S.; Perdomo, S.; Wedge, D. C.; Brennan, P.; Stratton, M.; Alexandrov, L. B.
10.1101/2025.06.06.658321 — cancer biology — Posted on 2025-06-09
2978 Forecasting oncogene amplification and tumour suppressor deletion
Hernando, B.; Fernandez-Sanroman, A.; Cadiz, A.; Santamaria, P. G.; Gomez-Sanchez, D.; Escobar-Rey, M.; Chaves-Urbano, B.; Thompson, J. S.; Torres, M.; Ruiz de Garibay, G.; Adradas, V.; Alvarez, E.; The Pan Prostate Cancer Group, ; Tarabichi, M.; Lesluyes, T.; Coya, J. M.; Zugazagoitia, J.; Paz-Ares, L.; Macintyre, G.
10.1101/2025.06.06.658212 — genomics — Posted on 2025-06-09
2979 Persistent ECM Scarring Reprograms Intestinal Stem Cells to Drive Chronic Inflammation
Adir, I.; Sochen, C.; Menachem, A. H.; Lebon, S.; Toval, B.; Holiar, V.; Davidzohn, N.; Salame, T. M.; Rosenhek-Goldian, I.; Savickas, S.; Sabino, F.; auf dem Keller, U.; Biton, M.; Sagi, I.
10.1101/2025.06.08.658481 — immunology — Posted on 2025-06-09
2980 TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950
Lackner, A.; Leonidas, L.; Macapagal, A.; Lee, H.; Xu, H.; Qiu, Y.; Campos, M.; Cabral, J. E.; Onyuru, J.; Kulkarni, S.; Albrecht, L.; Hoffman, H. M.; McNulty, R.
10.1101/2025.06.05.658156 — immunology — Posted on 2025-06-09
2981 Structural insights into wiring specificity in the neuromuscular system through the Beat-Side complex
Priest, J. M.; Zhang, R.; Olechwier, A. M.; Caspi-Lebovic, A. B.; Ashley, J.; Aher, V.; Carrillo, R. A.; Özkan, E.
10.1101/2025.06.05.656487 — neuroscience — Posted on 2025-06-09
2983 Multivariate Resting-State Functional Connectivity Features Linked to Transdiagnostic Psychopathology in Early Psychosis
Wang, H. R.; Liu, Z.-Q.; Nomi, J. S.; Schleifer, C. H.; Bearden, C. E.; Misic, B.; Uddin, L. Q.; Karlsgodt, K. K.
10.1101/2025.06.04.654984 — neuroscience — Posted on 2025-06-09
2985 Neurological effects induced by micro- and nanoplastics in fish: a systematic review and meta-analysis
Klippel Zanona, Q.; Gallas-Lopes, M.; Alves Marconi, G.; Nachtigall Lazzarotto, I.; Piato, A.; Herrmann, A. P.; Calcagnotto, M. E.
10.1101/2025.06.07.658168 — neuroscience — Posted on 2025-06-09
2986 Development of a Novel Benzodiazepine to Delineate Peripheral GABA-A Signaling Mechanisms in Visceral Pain Syndromes
Poslusney, M. S.; Li, Q.; Buchler, I. P.; Huang, Y.; Liu, L.; Zhu, Y.; Kulkarni, S.; Carr, G.; DeBrosse, A.; White, N.; Peters, D.; Barrow, J. C.; Pasricha, P. J.
10.1101/2025.06.08.658501 — neuroscience — Posted on 2025-06-09
2988 Intra-subtype heterogeneity shapes treatment response in KMT2A-rearranged ALL across all age groups
Hartmann, A. M.; Bastian, L.; Barz, M. J.; Haas, J.; Amelunxen, E.; Ehm, P.; Lenk, L.; Kotrova, M.; Beder, T.; Steffen, F.; Rauwolf, K.; Wolgast, N.; Bendig, S.; Bozzetti, C.; Alten, J.; Mondal, M.; Rademacher, A.; Heymann, J.; Walter, W.; Haferlach, C.; Ströh, A.-S.; Bergmann, A. K.; Burmeister, T.; Gökbuget, N.; Bornhauser, B.; Bourquin, J.-P.; Brüggemann, M.; Schrappe, M.; Cario, G.; Baldus, C. D.
10.1101/2025.06.05.657589 — cancer biology — Posted on 2025-06-09
2989 A high-throughput immunopeptidome platform for MHC II alleles to characterize antigen-specific CD4 + T cells
Chen, J.; Zhu, X.; Huo, J.; Wu, S.; Zhou, T.; Cheng, C.; Dong, H.; Li, Y.; Chen, Y.; Dong, X.
10.1101/2025.06.05.658000 — biochemistry — Posted on 2025-06-09
2990 De novo genome assembly of Ansell's mole-rat (Fukomys anselli)
Bekavac, M.; Coimbra, R.; Busa, V. F.; Behm, M.; Wagner, R. E.; Goncalves, A.; Begall, S.; Frye, M.; Odom, D. T.
10.1101/2025.06.03.657636 — genomics — Posted on 2025-06-09
2991 A pan-generic marker panel for apples to enable genetic research and breeding across Malus species
Sakina, A.; Tegtmeier, R.; Feulner, H.; Hickok, D.; Svara, A.; Cho, P.; Clark, M.; Kilian, A.; Glaubitz, J.; Sun, Q.; Khan, A.
10.1101/2025.06.05.657940 — genetics — Posted on 2025-06-09
2994 Duration of immunity following infection with moderately virulent ASFV
Friedrichs, V.; Deutschmann, P.; Wernike, K.; Carrau, T.; Beer, M.; Blome, S.; Schäfer, A.
10.1101/2025.06.05.657993 — immunology — Posted on 2025-06-09
2995 CFTR mutation leads to intrinsic dysfunction in neutrophils from people with Cystic Fibrosis
Robledo-Avila, F. H.; Rascon, R.; Montanez-Barragan, A.; Loyo-Celis, V.; Singh, H.; McCoy, K. S.; Kopp, B. T.; Partida-Sanchez, S.
10.1101/2025.06.08.656500 — immunology — Posted on 2025-06-09
2996 Interlinked roles for HEB and Id3 in fetal gamma-delta T cell commitment and functional programming
Selvaratnam, J. S.; Barbosa da Rocha, J. D.; Rajan, V.; Wang, H.; Reddy, E. C.; Gams, M. S.; Murre, C.; Guidos, C. J.; Zuniga-Pflucker, J. C.; Anderson, M. K.
10.1101/2025.06.08.658490 — immunology — Posted on 2025-06-09
2997 Ambient Pollution Components and Sources Associated with Hippocampal Architecture and Memory in Pre-Adolescents
Rosario, M. A.; Sukumaran, K.; Bottenhorn, K. L.; de Jesus, A.; Cardenas-Iniguez, C.; Ahmadi, H.; Habre, R.; Abad, S.; Pine, J. G.; Barch, D. M.; Schwartz, J.; Hackman, D. A.; Chen, J.-C.; Herting, M. M.
10.1101/2025.06.05.658105 — neuroscience — Posted on 2025-06-09
2999 Youth-associated protein TIMP2 alters microglial state and function in the context of aging
Hemmer, B. M.; Ferreira, A. C.; Philippi, S. M.; Petridis, S. F.; Phan, A.; Castellano, J. M.
10.1101/2025.05.20.655226 — neuroscience — Posted on 2025-06-09
3002 In vivo RUBISCO activity in Synechocystis is regulated by RuBP availability
Wittemeier, L.; Arrivault, S.; Neumann, N.; Macek, B.; Schmidt, N.; Hagemann, M.; Kopka, J.
10.1101/2025.06.06.658252 — plant biology — Posted on 2025-06-09
3003 Calorie restriction suppresses aging alpha cell pro-inflammatory signaling
Schleh, M.; Cambraia, A.; Cutler, M.; Ferguson, G.; Arrojo e Drigo, R.
10.1101/2025.06.04.657914 — physiology — Posted on 2025-06-09
3004 Bacteria-induced colitis in naked mole rats is alleviated by probiotic treatment: a new mammalian model for acute inflammatory disease
Hart, D. W.; Ng, A. S.; Gazinska, P.; Goldin, R.; Gopal, P.; O'Dell, N.; Montazid, S.; East, J. E.; Tomlinson, I. P.; Koch, N.; Bennett, N. C.; Irshad, S.
10.1101/2025.06.05.658065 — pathology — Posted on 2025-06-09
3005 Observing intersubunit dynamics in single yeast ribosomes
Das, A.; Ivanov, A. V.; Wakabayashi, H.; Grove, A. K.; Ermolenko, D. N.
10.1101/2025.06.05.658109 — biophysics — Posted on 2025-06-09
3006 Membrane phosphoinositides allosterically tune β-arrestin dynamics to facilitate GPCR core engagement
Janetzko, J.; Deutsch, J.; Shi, Y.; Siepe, D. H.; Masureel, M.; Liu, W.; Viner, R.; Inoue, A.; Kobilka, B. K.; Shivnaraine, R. V.
10.1101/2025.06.06.658200 — biophysics — Posted on 2025-06-09
3007 A light-weight segmentation method for multi-state Brownian trajectories
El Korde, I.; Lewis, J. M.; Clarkson, E.; Dam, T.; Jönsson, P.; Ambjörnsson, T.; Stenhammar, J.
10.1101/2025.06.05.658053 — biophysics — Posted on 2025-06-09
3011 PLIERv2: bigger, better and faster
Subirana-Granes, M.; Nandi, S.; Zhang, H.; Chikina, M.; Pividori, M.
10.1101/2025.06.05.658122 — bioinformatics — Posted on 2025-06-09
3013 PIVOT: an open-source tool for multi-omic spatial data registration
Forjaz, A.; Romero, V. M.; Reucroft, I.; Eminizer, M.; Kramer, D.; Higuera, D.; Mojdeganlou, H.; Guerrero, P. A.; Min, J.; Wetzel, M.; Lvovs, D.; Valentin, A.; Shin, S. M.; Xuan, Y.; Sears, R. C.; Chin, K.; Maitra, A.; Fertig, E. J.; Ho, W. J.; Kagohara, L. T.; Wood, L. D.; Wirtz, D.; Sidiropoulos, D. N.; Kiemen, A. L.
10.1101/2025.06.08.658506 — bioinformatics — Posted on 2025-06-09
3017 A Tunable Pulmonary Organoid Model Demonstrates Compositionally Driven Epithelial Plasticity and Immune Polarization
Edelstein, S. E.; Mizoguchi, S.; Gracia, M. T.; Wang, N.; Lee, V.; Kim, H.; Haynes, C.; Danelski, C.; Tsuchiya, T.; Sauler, M.; Raredon, M. S. B.
10.1101/2025.06.05.658120 — bioengineering — Posted on 2025-06-09
3018 Mechanisms of KCNQ1 gating modulation by KCNE1/3 for cell-specific function
Cui, C.; Zhao, L.; Kermani, A. A.; Du, S.; Pipatpolkai, T.; Jiang, M.; Chittori, S.; Tan, Y.; Shi, J.; Delemotte, L.; Cui, J.; Sun, J.
10.1101/2025.06.08.658478 — biochemistry — Posted on 2025-06-09
3019 Unraveling the start element and regulatory divergence of core promoters across the domain Bacteria
Kuo, S.-T.; Chang, J. K.; Chang, C.; Shen, W.-Y.; Hsu, C.; Lai, S.-W.; Chou, H.-H. D.
10.1101/2025.01.23.634641 — genomics — Posted on 2025-06-09
3020 Impact of Sperm Fractionation on Chromosome Positioning, Chromatin Integrity, DNA Methylation and Hydroxymethylation Level
Graczyk, Z.; Kostyk, J.; Pospieszna, J. A.; Myslicka, Z.; Kamieniczna, M.; Fraczek, M.; Olszewska, M.; Kurpisz, M.
10.1101/2025.06.07.658443 — genetics — Posted on 2025-06-09
3022 Generation and characterization of a mouse model of conditional Chd4 knockout in the endometrial epithelium.
Chandler, R. L.; Harkins, S. K.; Skalski, H. J.; Bennett, A. Z.; Pavliscak, L.; Arendt, A. R.; Wood, L.; Moldovan, G. E.
10.1101/2025.06.05.658183 — developmental biology — Posted on 2025-06-09
3023 Primitive Hepatoblasts Driving Early Liver Development
Iwasawa, K.; Koike, H.; Reza, H. A.; Milton, Y.; Kishimoto, K.; Thorner, K.; Granitto, M.; Saiki, N.; Santangelo, C.; Glaser, K.; Kimura, M.; Bondoc, A.; Lim, H.-W.; Morimoto, M.; Iwafuchi, M.; Wells, J. M.; Zorn, A. M.; Takebe, T.
10.1101/2025.06.08.658502 — developmental biology — Posted on 2025-06-09
3024 Canonical nuclear envelope protein emerin regulates structure and integrity of the erythrocyte plasma membrane
O'Brien, B.; Oliver, J.; Thompson, E. N.; Mayday, M. Y.; Mancuso, R.; Jha, A.; Kwan, J.; Bonne, G.; Ben Yaou, R.; Leturcq, F.; Bai, S.; Nottoli, T.; Hwa, J.; Krause, D. S.; Gallagher, P. G.; Gu, S. X.; Martin, K. A.
10.1101/2025.06.06.658339 — cell biology — Posted on 2025-06-09
3025 Diminished and altered cellular senescence response in delayed wound healing of aging
Shvedova, M.; Thanapaul, R. J. R. S.; Wang, Q.; Shin, G. H.; Dhillon, J.; Roh, D. S.
10.1101/2025.06.08.658533 — cell biology — Posted on 2025-06-09
3027 Remodelled cholesteryl ester enriched lipid droplets fuel flavivirus morphogenesis
Banducci-Karp, A.; Brixton, S.; Shah, P. M.; Li, M.-Y.; Bancroft, J.; Riepsaame, J.; Dhaliwal, R.; Melia, C. E.; Malavige, G. N.; Sanyal, S.; Bancroft, J.
10.1101/2025.06.07.658178 — cell biology — Posted on 2025-06-09
3029 G1 and G2 ApolipoproteinL1 modulate macrophage inflammation and lipid accumulation through the polyamine pathway
Liu, E.; Wright, M.; Kearney, A. O.; Caza, T.; Yang, J. Y.; Garcia, V.; Dadi, A. O.; Ishibe, S.; Chandel, N. S.; Zhang, H.; Benjamin Thorp, E.; Lin, J.
10.1101/2025.06.06.658371 — cell biology — Posted on 2025-06-09
3030 The Anti-Inflammatory Role of GPNMB in Post-Traumatic Osteoarthritis
Al-Adlaan, A. A.; Cook, B.; Solorzano, E.; Hussein, N. J.; Jaber, F. J.; Kronk, T. A.; Frangiamore, S.; Ball, H. C.; Safadi, F. F.
10.1101/2025.06.06.658389 — cell biology — Posted on 2025-06-09
3031 Phosphoproteomics Maps Calcineurin-NFAT-DSCR1.4 Signaling as Druggable Axis in Gαq-R183Q-Driven Capillary Malformations
Xu, T.; Janssen, V.; Reinhard, N. R.; Sobrevals-Alcaraz, P.; van Es, R. M.; de Haan, A.; de Swart, J.; Wehrens, M.; Wolkerstorfer, A.; van der Horst, C. M. A. M.; Vos, H. R.; Huveneers, S.
10.1101/2025.06.07.658432 — cell biology — Posted on 2025-06-09
3032 Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections
Ngo, C.; Pierini-Malosse, C.; Rahmani, K.; Valente, M.; Collinet, N.; Bessou, G.; Guerry, C.; Fabregue, M.; Mathieu, S.; Sharkaoui, S.; Mazzoli, S.; Sansoni, A.; Fiore, F.; Laprie, C.; Alexopoulou, L.; GAYA, M.; Gregoire, C.; Broggi, A.; Wurbel, S.; Rua, R.; Haidar, N.; Milpied, P.; Escaliere, B.; Phong, T.; Fallet, M.; Chasson, L.; Tran, H.; Le Bert, M.; Malissen, B.; ZARUBICA, A.; DALOD, M.; Tomasello, E.
10.1101/2024.05.20.594961 — immunology — Posted on 2025-06-09
3033 Rational Design of Immunogenic Nanoparticles as a Platform for Enhanced Ovarian Cancer Immunotherapy in Mice
Tang, L.; Marwedel, B.; Dang, C.; Olewine, M.; Jun, M.; Naydenkov, P.; Medina, L. Y.; Gayoso, V.; Doan, N.; OLeary, S. L.; Schiavone, C.; Cave, J.; Howard, T.; Watt, J. D.; Dogra, P.; Serda, R. E.; Noureddine, A.
10.1101/2025.06.05.657862 — immunology — Posted on 2025-06-09
3034 Opposing responses of hippocampal theta oscillations to running and a forelimb-dominated sensorimotor behavior
Holguin, G.; Jorgensen, K.; Tapia, A.; Jordan, G. A.; Vishwanath, A.; Barnes, C. A.; Cowen, S. L.
10.1101/2025.06.08.658384 — neuroscience — Posted on 2025-06-09
3035 Error encoding in human speech motor cortex
Hou, X.; Iacobacci, C.; Card, N. S.; Wairagkar, M.; Singer-Clark, T.; Kunz, E. M.; Fan, C.; Kamdar, F.; Hahn, N.; Hochberg, L. R.; Henderson, J. M.; Willett, F. R.; Brandman, D. M.; Stavisky, S. D.
10.1101/2025.06.07.658426 — neuroscience — Posted on 2025-06-09
3036 A Radiomic Approach to Clinical MRI Refines the Thalamus-Cognition Link in Multiple Sclerosis
Buyukturkoglu, K.; Lu, L.; Davis, L.; Orellana, R. E.; White, C. C.; Sun, R.; Ozcelik, S.; Isenstein, N. M.; Onomichi, K. B.; Iqbal, R.; Zhao, B.; Stern, Y.; Zeydan, B.; Kantarci, O. H.; Riley, C. S.; De Jager, P. L.
10.1101/2025.06.05.657698 — neuroscience — Posted on 2025-06-09
3037 Whisker stimulation reinforces a resting-state network in the barrel cortex: nested oscillations and avalanches
Mariani, B.; Guevara, R.; Tambaro, M.; Maschietto, M.; Leparulo, A.; Vassanelli, S.; Suweis, S.
10.1101/2025.06.06.658305 — neuroscience — Posted on 2025-06-09
3042 Phytoene synthase modulates seed longevity via the action of β-carotene derived metabolites
Hazra, A.; Rao, S.; Zhou, X.; Christel, M. J.; Wrightstone, E.; Yang, Y.; Fish, T.; Thannhauser, T.; Liu, J.; Mazourek, M.; Li, L.
10.1101/2025.06.05.658166 — plant biology — Posted on 2025-06-09
3045 Structural Acrobatics of IAA7: Exercising Fuzzy Regions to Aid Auxin-Mediated Catalysis
Parra, J. O. F.; Ott, M.; Bathia, T.; Emenecker, R.; Wolff, M.; Thalhammer, A.; Matschi, S.; Villalobos, L. I. A. C.
10.1101/2025.06.08.657175 — biophysics — Posted on 2025-06-09
3046 Biological Processes as Exploratory Dynamics
Kondev, J.; Kirschner, M. W.; Garcia, H. G.; Salmon, G.; Phillips, R.
10.1101/2025.06.06.657857 — biophysics — Posted on 2025-06-09
3050 Formation of a μ-oxo nucleophile enables efficient hydrolysis by a trinuclear metal center in Family II inorganic pyrophosphatase
Maruoka, S.; Kametani, Y.; Magome, E.; Setoyama, H.; Kawamoto, M.; Horitani, M.; Teramoto, T.; Kakuta, Y.; Shiota, Y.; Yoshizawa, K.; Watanabe, K.
10.1101/2025.06.08.658471 — biophysics — Posted on 2025-06-09
3052 tidypopgen: Tidy Population Genetics in R
Carter, E. J.; Tysall, E. E.; Hodgson, J.; Manica, A.
10.1101/2025.06.06.658325 — bioinformatics — Posted on 2025-06-08
3054 Affordable plasmonic biosensing: democratizing SERS with scalable, field-compatible substrate fabrication
Arora, S.; Ginde, V.; Tanwar, S.; Chazli, M. E.; Bhatt, R.; Edelman, E.; Paria, D.; Barman, I.
10.1101/2025.06.05.658202 — bioengineering — Posted on 2025-06-09
3055 Scaffold-free cryopreservable cartilage grafts obtained from hiPSC-derived chondroprogenitor cells for airway reconstruction with growth adaptability
Hanaki, S.; Takao, T.; Fujisawa, Y.; Ota, T.; Osone, T.; Otake, S.; Iwai, R.; Deguchi, K.; Yamamoto, K.; Okuyama, H.; Takarada, T.
10.1101/2025.06.05.654989 — bioengineering — Posted on 2025-06-09
3056 PEG-Free Tunable Poly(2-Oxazoline) Lipids Modulate LNP Biodistribution and Expression In Vivo after Intramuscular Administration
Basham, C.; Haney, M.; Zhao, Y.; Lukyanov, K. A.; Kim, K.; Baysal, A.; Hutsell, H.; Kabanov, A. V.; Ramsey, J. D.
10.1101/2025.06.05.657891 — bioengineering — Posted on 2025-06-09
3057 A Cryptic Interfacial Pocket Uncovered in Full CRL4CRBN-IKZF3 Ubiquitylation Complex Enhances IMiD Efficacy
Deng, Z.; Ai, H.; Shi, Q.; Liang, J.; He, Z.; Zheng, J.; Li, H.; Zhang, L.; He, W.; Tao, S.; Zheng, Q.; He, W.; Pan, M.; Liu, L.
10.1101/2025.06.08.658527 — biochemistry — Posted on 2025-06-09
3059 Cell-specific RNA isoform remodeling in the aging mouse brain
Rehman, A.; Duffy, M.; Gresova, K.; Belair, C.; Yang, N.; Wang, L.; Lee, C. T.; Payea, M.; Malla, S.; Dar, S. A.; Sen, P.; Cookson, M. R.; Maragkakis, M.
10.1101/2025.06.05.658133 — genomics — Posted on 2025-06-08
3061 Rapid divergence of male and female mitochondrial genomes in a basal protobranch bivalve Yoldia hyperborea
Fedorov, D. A.; Bezmenova, A. V.; Ezhova, M. A.; Kolbasova, G. D.; Tzetlin, A. B.; Neretina, T. V.; Knorre, D. A.
10.1101/2025.06.07.658435 — evolutionary biology — Posted on 2025-06-08
3063 Ex ante analyses can predict natural enemy efficacy in biological control
Gutierrez, A. P.; Ponti, L.; Neuenschwander, P.; Yaninek, J. S.; Baumgärtner, J. U.; Herren, H. R.
10.1101/2025.06.06.658262 — ecology — Posted on 2025-06-08
3064 Predicting Ecosystem Resilience Using Multi-Agent Reinforcement Learning
Strannegard, C.; Palak, M.; Emgsner, N.; Stocco, A.; Antonelli, A.; Silvestro, D.
10.1101/2025.06.07.658424 — ecology — Posted on 2025-06-09
3069 Epigenetic Regulation of Chondrogenesis: JMJD3 and UTX as Key Targets for Gene-Modified Mesenchymal Stem Cell Therapy in Cartilage Tissue Engineering
Allas, L.; Aury-Landas, J.; Rochoux, Q.; Julien, A.; Lhuissier, E.; Lente, M.; Brochard, S.; Veyssiere, A.; Boumediene, K.; Bauge, C.
10.1101/2025.06.06.658259 — developmental biology — Posted on 2025-06-08
3070 Genetic modulation of mitochondrial NAD+ regeneration does not prevent dopaminergic neuron dysfunction caused by mitochondrial complex I impairment
D'Alessandro, K. B.; Zampese, E.; Blum, J. L. E.; Kuusik, B.; Palmiotti, A.; Davidson, S. M.; Reczek, C. R.; Surmeier, D. J.; Chandel, N. S.
10.1101/2025.06.07.658365 — cell biology — Posted on 2025-06-08
3073 Unheralded high MHC Class II polymorphism in the abundant Atlantic herring resolved by long-read sequencing
Jamsandekar, M.; Sangdehi, F. M.; Berg, F.; Criscitiello, M. F.; Davis, B. W.; Larsson, M.; Li, j.; Pettersson, M. E.; Andersson, L.
10.1101/2025.06.08.658498 — immunology — Posted on 2025-06-08
3075 Transcriptome-Proteome analysis of human naive and memory B cell subsets reveal isotype and subclass-specific phenotypes
Koers, J.; Hoogendijk, A. J.; Tol, S.; van Alphen, F.; Derksen, N.; van den Biggelaar, M.; Rispens, T.
10.1101/2025.06.05.657894 — immunology — Posted on 2025-06-08
3076 Long-Range Input to Cortical Microcircuits Shapes EEG-BOLD Correlation
Chien, V. S. C.; Jiricek, S.; Knoesche, T. R.; Hlinka, J.; Schmidt, H.
10.1101/2025.06.06.658058 — neuroscience — Posted on 2025-06-08
3077 Modality-Agnostic Decoding of Vision and Language from fMRI
Nikolaus, M.; Mozafari, M.; Berry, I.; Asher, N.; Reddy, L.; VanRullen, R.
10.1101/2025.06.08.658221 — neuroscience — Posted on 2025-06-08
3078 Infection-Specific Reprogramming of Microglia Reveals Distinct Virulence Pathways Linking Periodontal Pathogens to Alzheimer's Disease
Kaminska, M.; Dudzinska, N.; Klapper, A.; Geissler, S.; Taudte, N.; Greiser, S.; Potempa, J.; Cynis, H.; Mydel, P.
10.1101/2025.06.06.658266 — neuroscience — Posted on 2025-06-08
3079 Nociceptin receptor and ligand in Alzheimer's disease:Implications for psychiatric symptoms and circadianregulation
Vogelgsang, J.; Gregory, S.; Smith, G. W.; Abston, J.; Kuhn, M.; Pizzagalli, D. A.; Berretta, S.
10.1101/2025.06.04.657953 — neuroscience — Posted on 2025-06-08
3081 Magnetoelectric nanodiscs diminish motor deficits in a model of Parkinson's disease
Kim, Y. J.; De Comite, A.; Paniagua, E. V.; Selvaraji, S.; Frey, E.; Mondal, R.; Seethapathi, N.; Anikeeva, P.
10.1101/2025.06.04.657885 — neuroscience — Posted on 2025-06-08
3087 Vertical rooting caused by enhanced functional allele of qSOR1 improves rice yield under drought stress
Kawai, T.; Kitomi, Y.; Kuroda, R.; Nakata, R.; Iba, M.; Soma, F.; Teramoto, S.; Yamazaki, T.; Sugimoto, K.; Uga, Y.
10.1101/2025.06.07.658467 — plant biology — Posted on 2025-06-08
3088 Salicylic acid accumulation correlates with low anthocyanin production in Arabidopsis
Drs, M.; Iakovenko, O.; Orozco, J. S. H.; Trhlinova, P. B.; Markovice, V.; Zarsky, V.; Pecenkova, T.; Janda, M.
10.1101/2025.06.08.658514 — plant biology — Posted on 2025-06-08
3091 Evaluation of graphene oxide-mediated NET formation using HL-60-derived neutrophil-like cells
Fukuhara, K.; Obama, T.; Ohinata, H.; Takaki, T.; Kato, M.; Totsuka, Y.; Itabe, H.; Ohno, A.
10.1101/2025.06.06.658248 — pharmacology and toxicology — Posted on 2025-06-08
3096 Quantifying Protein-Protein Interaction with a Spatial Attention Kinetic Graph Neural Network
xu, y.; Xia, W.; Zhang, C.; Liu, X.; Ju, C.; Dai, X.; Xie, P.; Wang, Y.; Chen, G.; Zhang, J.
10.1101/2025.06.04.657832 — bioinformatics — Posted on 2025-06-08
3098 CalciumInsights: An Open-Source, Tissue-Agnostic Graphical Interface for High-Quality Analysis of Calcium Signals
Gomez, D. S.; Rosas, N. C. P.; Contreras, G. I. M.; Brana, S. R. C.; Zhang, W.; Mim, M. S.; Tan, S. G.; Gazzo, D.; Tepole, A. B.; Deng, Q.; Reeves, G. T.; Isaza, C. E.; Staiger, C. J.; Umulis, D. M.; Zartman, J. J.; Rios, M. C.
10.1101/2025.06.04.657923 — bioengineering — Posted on 2025-06-08
3103 High-altitude mountaineering induces adaptive gut microbiome shifts associated with dietary intake and performance markers
Karpecka-Gałka, E.; Zielinska, K.; Fraczek, B.; Łabaj, P.; Kosciołek, T.; Huminska-Lisowska, K.
10.1101/2025.06.06.658263 — genomics — Posted on 2025-06-08
3104 Unique molecular identifier-based single strand mitochondrial DNA sequencing for rare substitution mutations
Li, Z. E. S.; Dunn, R.; Caloren, L. C.; Ziada, A. S.; Chapman, H.; Gadawska, I.; Cote, H. C. F.
10.1101/2025.06.05.657263 — genomics — Posted on 2025-06-08
3105 Tracing genome size dynamics in sharks and rays with inclusive sequence analysis by the Squalomix Consortium
Kuraku, S.; Kawaguchi, Y.; Misawa, R.; Niwa, T.; Kadota, M.; Saito, K.; Godo, W.; Sakamoto, T.; Takagi, W.; Isobe, S.; Shirasawa, K.; Kawaguchi, A.
10.1101/2025.06.08.657570 — genomics — Posted on 2025-06-08
3109 RetiGene, a comprehensive gene atlas for inherited retinal diseases (IRDs)
Quinodoz, M.; Celik, E.; Kamdar, D.; Cancellieri, F.; Kaminska, K.; Ullah, M.; Barberan-Martinez, P.; Bouckaert, M.; Corton, M.; Delanote, E.; Fernandez-Caballero, L.; Garcia, G. G.; Holtes, L. K.; Karali, M.; Lopez, I.; Peter, V. G.; Schneider, N.; Vincke, L.; Ayuso, C.; Banfi, S.; Bocquet, B.; Coppieters, F.; Cremers, F.; Inglehearn, C.; Iwata, T.; Kalatzis, V.; Koenekoop, R. K.; Millan, J. M.; Sharon, D.; Toomes, C.; Rivolta, C.
10.1101/2025.06.08.653722 — genetics — Posted on 2025-06-08
3111 Combining population genomics with ancient DNA to understand island colonization history of the Madagascar turtle dove
Dwivedi, N.; Heighton, S. P.; Laso-Jadart, R.; Verry, A. J. F.; Nieto-Heredia, A.; Lesturgie, P.; Khost, D.; Bohec, M.; Sackton, T. B.; Chikhi, L.; Orlando, L.; Hume, J. P.; Achaz, G.; Theves, C.; Mona, S.; Warren, B. H.
10.1101/2025.06.05.658009 — evolutionary biology — Posted on 2025-06-08
3115 Variability in foraging ranges of snow petrels and implications for breeding distribution and use of stomach-oil deposits as proxies for paleoclimate
Wakefield, E. D.; McClymont, E. L.; Descamps, S.; Grecian, W. J.; Honan, E. M.; Rix, A. S.; Robert, H.; Sandoy Brathen, V.; Phillips, R. A.
10.1101/2025.06.06.658237 — ecology — Posted on 2025-06-08
3120 Regulatory elements of pancreas development license the initiation of pancreatic ductal adenocarcinoma
Ballester, M.; Kurilla, A.; Dai, Y.; Maurer, C.; Espinet, E.; Hoj, K.; Marisch Delgado, A.; Seymour, P. A.; Omar, S.; Rift, C. V.; Hasselby, J.; Klaussen, P.; Vilmann, P.; Sandelin, A.; Arnes Perez, L.
10.1101/2025.06.06.658264 — cell biology — Posted on 2025-06-08
3121 EndoNB: A general strategy to study the internalization of cell surface proteins
Lenaerts, A.-S.; Krishtal, J.; Arima, T.; Leskovar, N.; Zeinoddin, N.; Almeida-Souza, L.
10.1101/2025.06.08.658482 — cell biology — Posted on 2025-06-08
3122 Sensory stimuli and cilium trafficking defects trigger the release of ciliary extracellular vesicles from multiple ciliary locations
Lobo, T. G. Q.; Haasnoot, G. H.; Nawrocka, A.; Bruggeman, C. W.; Razzauti, A.; Peterman, E. J. G.; Laurent, P.
10.1101/2025.06.06.658075 — cell biology — Posted on 2025-06-08
3123 Integrative Chemical Genetics Platform Identifies Condensate Modulators Linked to Neurological Disorders
Poch, D.; Mukherjee, C.; Mallik, S.; Todorow, V.; Kuiper, E. F. E. J.; Dhingra, N.; Surovtseva, Y. V.; Schlieker, C.
10.1101/2025.06.07.658469 — cell biology — Posted on 2025-06-08
3124 The STORE.2 model of the T cell proliferative phase considering c-Myc
Christian, D. A.; Bhartt, T. P. S.; Lanzar, Z.; Seyyedizadeh, S. F.; Hunter, C. A.; Adams, T. A.
10.1101/2025.06.05.658086 — immunology — Posted on 2025-06-08
3128 Single-cell and cell-type-level insights into stress-driven immune regulation relevant to disease
Benavides, S.; Kosyk, O.; Carpenter, L.; Georgiou, C.; Miller, B. C.; Stanley, N.; Zannas, A. S.
10.1101/2025.06.05.658150 — immunology — Posted on 2025-06-08
3129 Comparing electromyography, accelerometry, and visual inspection to assess the resting motor threshold for transcranial magnetic stimulation
Hamoline, G.; Lunardi, A. E.; Moreno-Verdu, M.; Waltzing, B. M.; Van Caenegem, E. E.; MacAteer, S.; Hardwick, R. M.
10.1101/2025.06.04.657787 — neuroscience — Posted on 2025-06-08
3130 Astrocytic CREB regulates transcriptional, neuronal, and behavioral responses to cocaine
Holt, L. M.; Minier-Toribio, A.; Futamura, R.; Browne, C. J.; Martinez-Rivera, F. J.; Markovic, T.; Gyles, T. M.; Yeh, S.-y.; Parise, E. M.; Rivera, M.; Brenner, C.; Yim, Y. Y.; Kondev, V.; Estill, M.; Yan, S.; Keane, E.; Labanca, A.; Rojas, G.; Dong, Y.; Shen, L.; Nestler, E. J.
10.1101/2025.06.04.657899 — neuroscience — Posted on 2025-06-08
3134 Disrupted Forward Connectivity in Parieto-temporal Network Impairs Memory Performance in Alzheimer's Disease
Suksangkharn, Y.; Schott, B. H.; Zeidman, P.; Vockert, N.; Lattmann, R.; Schütze, H.; Yakupov, R.; Peters, O.; Hellmann-Regen, J.; Preis, L.; Ersözlü, E.; Priller, J.; Spruth, E. J.; Gemenetzi, M.; Schneider, A.; Fliessbach, K.; Wiltfang, J.; Bartels, C.; Rostamzadeh, A.; Glanz, W.; Incesoy, E. I.; Teipel, S.; Kilimann, I.; Goerss, D.; Laske, C.; Spottke, A.; Kronmüller, M.; Brosseron, F.; Lüsebrink, F.; Schmid, M.; Kleineidam, L.; Stark, M.; Hetzer, S.; Dechent, P.; Scheffler, K.; Jessen, F.; Maass, A.; Düzel, E.; Ziegler, G.
10.1101/2025.06.05.658022 — neuroscience — Posted on 2025-06-08
3136 Sex-specific Effects of Outdoor Air Pollution on Subcortical Microstructure and Weight Gain: Findings from the ABCD Study
Rivas-Fernandez, M. A.; Ottino-Gonzalez, J.; Esaian, S.; Goldman, V.; Herting, M. M.; Alderete, T. L.; Adise, S.
10.1101/2025.06.04.657916 — neuroscience — Posted on 2025-06-08
3140 Adolescent alcohol consumption alters sex-specific behaviors associated with prefrontal functional connectivity in mice
Seemiller, L. R.; Unsal, H. S.; Xie, Y.; Hossain, M. S.; Tuttle, K.; Johnson-Dendy, B.; McDonald, E.; Drew, P. J.; Zhang, N.; Crowley, N. A.
10.1101/2025.06.05.658112 — neuroscience — Posted on 2025-06-08
3141 Genomic structural equation modeling of impulsivity and risk-taking traits reveals three latent factors distinctly associated with brain structure and development
Shishikura, M.; Liu, L.; Yu, E.; Zhu, R.; Vilar-Ribo, L.; Cupertino, R. B.; Palmer, A. A.; Sanchez-Roige, S.; Vainik, U.; Morys, F.; Gan-Or, Z.; Misic, B.; Dagher, A.
10.1101/2025.06.05.657840 — neuroscience — Posted on 2025-06-08
3142 Non-obese genetic type 2 diabetes causes brain and behavioral hallmarks of chronic stress
Romani-Perez, M.; Henry, M.; Pajot, C.; Bailbe, D.; Brossaud, J.; Buyannemekh, K.; Lucia, P.; Foury, A.; Rincel, M.; Lepinay, A.; Portha, B.; Turner, J.; Movassat, J.; DARNAUDERY, M.
10.1101/2025.06.08.658427 — neuroscience — Posted on 2025-06-08
3144 Macrophages amplify the spontaneous activity of damaged sensory neurons in a human co-culture model of neuropathic pain
Chrysostomidou, P.; Hore, Z.; Somma, D.; Vlachaki Walker, J. M.; Diallo, K.; Titterton, H.; Elmesmari, A.; Kurowska-Stolarska, M.; Denk, F.; Weir, G. A.
10.1101/2025.06.05.656880 — neuroscience — Posted on 2025-06-08
3145 Neurally-informed modelling unravels a single evidence accumulation process for choices and subsequent confidence reports
Grogan, J. P.; Vermeylen, L.; Mannion, S.-L.; McCabe, C.; Monakhovych, D.; Desender, K.; O'Connell, R. G.
10.1101/2025.06.05.658071 — neuroscience — Posted on 2025-06-08
3146 An amygdalopontine pathway promotes motor programs of ingestion
Lafferty, D. S.; Isaac, J.; Wolcott, J. S.; Phan, A.; Reck, L.; Lutas, A.
10.1101/2025.06.05.657686 — neuroscience — Posted on 2025-06-08
3148 Reduced inhibition, bursting, and accelerated oscillations drive early hippocampal hyperactivity in Alzheimer's disease
Meftah, S.; Kang, S.; Liu, M.; Wang, X.; Topcu, A. N.; Abad, M. M.; Koszeghy, A.; Wan, L.; Mullin, C.; Zoupi, L.; Gan, J.
10.1101/2025.06.05.658038 — neuroscience — Posted on 2025-06-08
3149 Gut miRNA regulates gut microbiome and Alzheimer pathology in App-knock-in mice
Hao, W.; Luo, Q.; Szabo, I. M.; Gasparoni, G.; Tierling, S.; Quan, W.; Chang, H.-F.; Wu, G.; Schulze-hentrich, J.; Liu, Y.
10.1101/2025.06.05.658056 — neuroscience — Posted on 2025-06-08
3150 UNWANTED AXON GROWTH: PTEN AND THE SUPPRESSION OF AXON PLASTICITY IN ADULT NERVES
Eaton, S.; Komirishetty, P.; Larouche, M.; Areti, A.; Ong, H.; Martinez, J.; Zochodne, D. W.
10.1101/2025.06.04.657750 — neuroscience — Posted on 2025-06-08
3151 Comparative chemosensory mechanisms underlying larval foraging and competitive advantage in Aedes albopictus and Aedes aegypti
Perets, D.; Ke, H.; Campli, G.; Sar-Shalom, E.; Krsticevic, F.; Yakir, E.; Waterhouse, R. M.; Wang, Y.; Papathanos, P. A.; Bohbot, J. D.
10.1101/2025.06.07.658027 — neuroscience — Posted on 2025-06-08
3152 Left Area PF as a Neural Marker of Technical Reasoning
Federico, G.; Ilardi, C. R.; Marangolo, P.; Bryche, C.; Metaireau, M.; Bluet, A.; Lesourd, M.; Rossetti, Y.; Osiurak, F.
10.1101/2025.06.04.657853 — neuroscience — Posted on 2025-06-08
3153 Visual blur disrupts the kinematic and temporal aspects of reach-grasp-lift movements.
Sheppard, W. E. A.; Campagnoli, C.; Wilkie, R. M.; Baraas, R. C.; Coats, R. O.
10.1101/2025.06.05.658186 — neuroscience — Posted on 2025-06-08
3157 iTissue
Zambrana, C.; Malod-Dognin, N.; Przulj, N.
10.1101/2025.06.04.657816 — systems biology — Posted on 2025-06-08
3158 Transposon-plasmid nesting enables fast response to fluctuating environments
Ha, Y.; Maddamsetti, R.; Chen, X.; Simsek, E.; Lee, D.; Son, H.; Lee, C.; Kussell, E.; You, L.
10.1101/2025.06.04.657954 — systems biology — Posted on 2025-06-08
3162 Biofabrication of gold nanoparticles (GNPs) synthesized from Dillenia indica leaves with their anticancer, antibacterial, and antioxidant activities.
GUPTA, A.; Pandey, B. C.; Yaseen, M.; Kushwaha, R.; Verma, J.; Chaudhary, P.; Manna, P. P.; Manhas, R. K.; Tiwari, I.; Kumari, N.
10.1101/2025.06.05.653664 — plant biology — Posted on 2025-06-08
3169 Stereospecific rapid activation of Transcription Factor EB (TFEB) by Levacetylleucine (NALL)
Galione, A.; Platt, F. M.; Churchill, G. C.; Patterson, M. C.; Factor, M.; Fields, T.; Davis, L. C.; Strupp, M.
10.1101/2025.06.06.657607 — pharmacology and toxicology — Posted on 2025-06-08
3170 Gut bacterial metabolite imidazole propionate potentiates Alzheimer's disease pathology
Vemuganti, V.; Kang, J. W.; Zhang, Q.; Martinez, R. A.; Harpt, J. L.; Harding, S. J.; Deming, Y.; Johnson, S. C.; Asthana, S.; Zetterberg, H.; Blennow, K.; Engelman, C.; Ulland, T. K.; Bäckhed, F.; Bendlin, B. B.; Rey, F. E.
10.1101/2025.06.08.657719 — pathology — Posted on 2025-06-08
3171 Single JAK2-V617F hematopoietic stem cells can initiate MPN in transplantations into non-conditioned recipient mice
Kimmerlin, Q.; Hilpert, M.; Hansen, N.; Guy, A.; Usart, M.; Stetka, J.; Sobieralski, P.; Fonseca, T. A.; Hao-Shen, H.; Skoda, R. C.
10.1101/2025.06.08.657469 — cancer biology — Posted on 2025-06-08
3173 Cryo-EM Sample Preparation with Soft-Landing and Laser Flash Melting
Barrass, S. V.; Esser, T. K.; Mowry, N. J.; Eriksson, L.; Hruby, J.; Seeley, L. T.; Curtis, W. A.; Baker, L. A.; Drabbels, M.; Rauschenbach, S.; Lorenz, U. J.
10.1101/2025.06.05.657968 — biophysics — Posted on 2025-06-08
3174 Enabling Real-Time Fluctuation-Based Super ResolutionImaging
Komen, J.; Tekpinar, M.; Huo, R.; De Zwaan, K.; Tomen, N.; Grussmayer, K.
10.1101/2025.06.05.658028 — biophysics — Posted on 2025-06-08
3185 Detection and Classification of Cervical Cancer Using Optimized Deep Learning Approach
Lalitha, S.; Baiju, B. V.; Mathivanan, S. K.; Nagappan, P.; Tyagi, C. S.; Mallik, S.
10.1101/2025.06.05.657998 — bioengineering — Posted on 2025-06-08
3188 Single-cell metabolic imaging and digital scoring of fat tissue remodeling by label-free metabolic imaging
Kim, M.; Berger, C.; Wolf, A.; Peteranderl, A.; Klingenspor, M.; Ntziachristos, V.; Li, Y.; Pleitez, M. A.
10.1101/2025.06.06.658032 — bioengineering — Posted on 2025-06-08
3189 Structural Basis for a Scaffolding Role of the COM Domain in Nonribosomal Peptide Synthetases
Diecker, J.; Hermanns, B.; Rueschenbaum, J.; Rasche, R.; Doerner, W.; Schroeder, A.; Kuemmel, D.; Mootz, H. D.
10.1101/2025.06.08.658476 — biochemistry — Posted on 2025-06-08
3193 Remote automated delivery of mechanical stimuli coupled to brain recordings in behaving mice
Burdge, J.; Jhumka, A.; Khan, A.; Ogundare, S.; Baer, N.; Fulton, S.; Kaplan, A.; Bistis, B.; Foster, W.; Thackray, J.; Toussaint, A.; Li, M.; Morizawa, Y. M.; Nazarian, J.; Yadessa, L.; George, A.; Delinois, A.; Mayiseni, W.; Loran, N.; Yang, G.; Margolis, D. J.; Abraira, V. E. G.; Abdus-Saboor, I.
10.1101/2024.05.06.592101 — neuroscience — Posted on 2025-06-08
3194 Integrated Histology and Molecular Profiling of Postmortem Human Auditory and Vestibular Organs via a Poly(Methyl Methacrylate)-Based Workflow
Baechinger, D.; Peyton, B.; Neubauer, J.; Dharmarajan, A.; Zhu, M.; O'Malley, J. T.; Kallupurackal, V.; Senese, S.; Brown, A.; Wunderlin, S.; Kreutzer, S.; Weiss, N. M.; Richter, H.; Dalbert, A.; Roeoesli, C.; Kipar, A.; Varga, Z.; von Rechenberg, B.; Amr, S.; Eckhard, A. H.
10.1101/2025.06.04.657716 — pathology — Posted on 2025-06-08
3195 Paclitaxel causes de novo induction of invasive breast cancer cells by repolarizing tumor-associated macrophages
Friedman-DeLuca, M.; Karagiannis, G. S.; Duran, C. L.; Eddy, R. J.; Shukla, S.; Li, J.; Condeelis, J. S.; Oktay, M. H.; Entenberg, D.
10.1101/2025.01.13.632767 — cancer biology — Posted on 2025-06-08
3196 Identification of disease-specific vulnerability states at the single-cell level
D'Antuono, M.; Sharp, M.; Chowdary, R.; Ivan, M. E.; Komotar, R. J.; Suter, R. K.; Ayad, N. G.
10.1101/2024.12.04.626873 — cancer biology — Posted on 2025-06-08
3197 NRCAM variant defined by microexon skipping is an essential, antigenically distinct, and targetable surface proteoform in high-grade gliomas
Sehgal, P.; Naqvi, A. S.; Higgins, M.; Liu, J.; Harvey, K.; Jarroux, J.; Kim, T.; Mankaliye, B.; Mishra, P.; Watterson, G.; Fine, J.; Davis, J.; Hayer, K. E.; Castro, A.; Mogbo, A.; Drummer, C.; Martinez, D.; Koptyra, M. P.; Ang, Z.; Wang, K.; Farrel, A.; Quesnel-Vallieres, M.; Barash, Y.; Spangler, J. B.; Rokita, J. L.; Resnick, A. C.; Tilgner, H. U.; DeRaedt, T.; Powell, D. J.; Thomas-Tikhonenko, A.
10.1101/2025.01.09.631916 — cancer biology — Posted on 2025-06-08
3198 Direct observation of conformational dynamics of intrinsically disordered proteins at the single-molecule level
Zargarbashi, S.; Dominguez, C.; Peters, M.; Yousefi, A.; Munday, S.; Wang, Y.; Chatterjee, S.; Hudson, A.; Gordon, R.; Mellor, C. J.; Xu, L.; Rahmani, M.; Ying, C.
10.1101/2025.05.26.656162 — biophysics — Posted on 2025-06-08
3199 Discovery of excited state proton transfer in flavin-based fluorescent protein with large Stokes shift
Nikolaev, A.; Markeeva, E.; Maksimov, E. G.; Yudenko, A.; Tropina, E. V.; Boldyrev, K. N.; Nikolaeva, Y. S.; Cherepanov, D. A.; Kovalev, K.; Yang, Y.; Borshchevskiy, V. I.; Kuznetsova, E.; Kuzmin, A.; Semenov, O.; Remeeva, A.; Gushchin, I.
10.1101/2025.06.07.658458 — biochemistry — Posted on 2025-06-08
3200 The Na+-pumping mechanism driven by redox reactions in the NADH-quinone oxidoreductase from Vibrio cholerae relies on dynamic conformational changes
Ishikawa-Fukuda, M.; Seki, T.; Kishikawa, J.-i.; Takahiro, M.; Okazaki, K.-i.; Kato, T.; Barquera, B.; Miyoshi, H.; Murai, M.
10.1101/2025.06.01.656757 — biochemistry — Posted on 2025-06-08
3202 Developmental dynamic transcriptomics reveals multiple effectors and transcription factors critical for Ditylenchus destructor parasitism
Chen, Y.; Zhang, S.; Zhou, Y.; Wang, X.; Bo, D.; Liao, Y.; Hu, B.; Zhang, Y.; Ashry, N. M.; Peng, D.; Sun, M.; Dai, D.
10.1101/2025.06.02.657539 — genomics — Posted on 2025-06-08
3203 Large-scale skin metagenomics reveals extensive prevalence, coordination, and functional adaptation of skin microbiome dermotypes across body sites
Li, C.; Ravikrishnan, A.; Wijaya, I.; Naim, A. N. M.; Gounot, J.-S.; Wearne, S.; On, Y. Y.; Ho, E. X. P.; Png, E.; Kwah, J. S.; Chandra, S. H. V.; Ang, Q. Y.; Chia, M.; Amanda, N. H. Q.; Ramaswami, S.; Yew, Y. W.; Loh, M.; Ong, R. Y.; Ng, F.; Lee, S. H.; Chan, J.; The HELIOS Study team, ; Regina, V. R.; Dawson, T.; Chambers, J.; Common, J.; Nagarajan, N.
10.1101/2025.04.24.650393 — genomics — Posted on 2025-06-08
3204 Short chain fatty acids regulate the chromatin landscape and distinct gene expression changes in human colorectal cancer cells
Kabir, T.; Connamacher, C. A.; Nadeem, Z.; Paul, M. R.; Smutny, M. R.; Lawler, Z. K.; Djomo, A. M.; Carroll, T.; Gates, L. A.
10.1101/2025.05.07.652677 — cell biology — Posted on 2025-06-08
3209 Biliverdin Reductase A is a major determinant of neuroprotective Nrf2 signaling
Vasavda, C.; Kothari, R.; Kaidery, N. A.; Chakraborty, S.; Tripathi, S. J.; Dhindsa, R. S.; Saberi, S.; Lefler, J. E.; Kothari, P.; Chaubey, K.; Snowman, A. M.; Ostrowski, M. C.; Barone, E.; Iyer, L. M.; Aravind, L.; Sharma, S. M.; Pieper, A. A.; Thomas, B.; Snyder, S. H.; Paul, B. D.
10.1101/2025.06.04.657936 — neuroscience — Posted on 2025-06-08
3212 An Integrated In Vitro Platform and Biophysical Modeling Approach for Studying Synaptic Transmission in Isolated Neuronal Pairs
Amos, G.; Vasiliauskaite, V.; Duru, J.; Saramago, M. L. A.; Schmid, T.; Suter, A.; Torren, F. C.; Küchler, J.; Ruff, T.; Vörös, J.; Vulic, K.
10.1101/2025.06.04.657933 — neuroscience — Posted on 2025-06-08
3214 Interprotomer Communication and Functional Asymmetry in H/ACA snoRNPs
Singh Panwar, H.; Vos, T. J.; Xie, X.; Jang, H. S.; Lee, H.; Sheldon, R.; Worden, E. J.; Kothe, U.
10.1101/2025.06.07.658439 — biochemistry — Posted on 2025-06-08
3215 Mechanisms of KCNQ1 gating modulation by KCNE1/3 for cell-specific function
Cui, C.; Zhao, L.; Kermani, A. A.; Du, S.; Pipatpolkai, T.; Jiang, M.; Chittori, S.; Tan, Y.; Shi, J.; Delemotte, L.; Cui, J.; Sun, J.
10.1101/2025.06.08.658478 — biochemistry — Posted on 2025-06-08
3216 A human ex vivo model of radiation-induced skin injury reveals p53-driven DNA damage signaling and recapitulates a TGFβ fibrotic response
Dodson, C.; Bilik, S. M.; DiBartolomeo, G.; Pachalis, H.; Siegfried, L.; Johnson, J. A. K.; Thaller, S. R.; Pastar, I.; Tomic-Canic, M.; Griswold, A. J.; Stone, R. C.
10.1101/2025.06.04.657901 — genomics — Posted on 2025-06-08
3218 Molecular profiling of bovine primordial germ cell specification and migration onset reveals a conserved program in bilaminar disc embryos
Guiltinan, C.; Botigelli, R. C.; Arcanjo, R. B.; Candelaria, J. I.; Lanzon, L. F.; Smith, J. M.; Becerra-Cortes, G.; Denicol, A. C.
10.1101/2025.06.04.657951 — developmental biology — Posted on 2025-06-08
3219 Spatial characterization of microbiota profiles along the gut in a widely used mouse model: effects of high-fat diet and fructooligosaccharides
Taillandier, P.; Voland, L.; Debedat, J.; Archambeau, A.; Dussaud, S.; Amouyal, C.; Patino-Navarrete, R.; Rey, F. E.; Adriouch, S.; Belda, E.; Clement, K.; Le Roy, T.
10.1101/2025.06.08.658095 — microbiology — Posted on 2025-06-08
3220 Characterization of a Novel Cell Wall-Associated Nucleotidase of Enterococcus faecalis that Degrades Extracellular c-di-AMP
Rivera, A. G. M.; Bala, A.; Casella, L. G.; Brunson, D. N.; Patel, A. M.; Wongso, E.; Flores-Mireles, A. L.; Lemos, J. A.
10.1101/2025.06.08.658492 — microbiology — Posted on 2025-06-08
3221 Competing gene regulatory networks drive naive and memory B cell differentiation
Demela, P.; Esposito, L.; Marchesan, P.; Bolognini, D.; Giacopuzzi, E.; Ricciardelli, E.; Ferrari, P.; Bombelli, S.; Peano, C.; Prati, D.; Valenti, L.; Soskic, B.
10.1101/2025.06.04.657836 — immunology — Posted on 2025-06-08
3222 Abrogating TGFβ signaling in TCR-engineered T cells and enhancing antigen processing by tumor cells promotes sustained therapeutic activity in pancreatic ductal adenocarcinoma
Tsai, A. K.; Rollins, M. R.; Ellefson, M. A.; Schmiechen, Z. C.; Burrack, A. L.; Hulbert, A.; Qian, G.; Zhang, H.; Provenzano, P.; Cruz-Hinojoza, E.; Butler, J. Z.; Smith, O. C. G.; O'Flanagan, S. D.; Krause, J.; Hickok, G. H.; Masopust, D.; Hingorani, S. R.; Greenberg, P. D.; Stromnes, I. M.
10.1101/2025.06.04.657887 — immunology — Posted on 2025-06-08
3223 IL-12 Secreting CAR-T Cells Reprogram the Tumor Microenvironment and Improve Efficacy Against Heterogeneous Models of Glioblastoma
Shen, S.; MOHAN, A.; Hotchkiss, K. M.; Quackenbush, S.; Patel, K.; Moelker, E.; Swartz, A.; Suryadevara, C.; Wilkinson, D.; Fecci, P.; Sanchez-Perez, L.; Sampson, J.; Patel, A.
10.1101/2025.06.04.657937 — immunology — Posted on 2025-06-08
3225 Glycated alpha-synuclein assemblies cause distinct Parkinsons disease pathogenesis in mice
Rajan, A.; Varghese, A.; Hashardeen, S. P.; Babu, A. T.; Vijayan, V.; Thakur, P.
10.1101/2025.06.04.657879 — neuroscience — Posted on 2025-06-08
3229 Engineering gene expression dynamics via self-amplifying RNA with drug-responsive non-structural proteins
Yousefpour, P.; Gregory, J. R.; Si, K.; Lonzaric, J.; Li, Y.; Wang, J.; Qureshi, K.; Ledbetter, A.; Melo, M. B.; Lemnios, A. A.; Dye, J.; Remba, T. K.; Yeung, R.; Rodriguez, L.; Guereca, M.; Wu, S.; Zhang, Y.; Dong, Y.; Weiss, R.; Irvine, D. J.
10.1101/2025.06.08.658495 — bioengineering — Posted on 2025-06-08
3231 Metabolic tuning enables immediate adaptation to energy stress in yeast
Bexley, K.; Ristova, M.; Sharma, S.; Spanos, C.; Chabes, A.; Tollervey, D.
10.1101/2025.06.06.658098 — molecular biology — Posted on 2025-06-08
3233 Remodeling of tRNA modification in Trypanosoma cruzi life forms
Silva, H. G.; De Freitas Nascimento, J.; Braga, M. S.; Silber, A. M.; Waldor, M.; da Cunha, J. P.; Kimura, S.
10.1101/2025.06.07.658256 — molecular biology — Posted on 2025-06-08
3234 TITAN-RNA: A hybrid-capture sequencing panel detects known and unknown Flaviviridae for diagnostics and vector surveillance
Murrell, C. M.; Sabaawy, A.; Wang, X.; Hashimoto, N.; Ceres, K.; Sun, Y.; Zehr, J. D.; Lehane, A.; Mader, E.; Bailey, N.; Lilly, M. V.; Plimpton, L.; Reboul, G.; Brown, J. J.; Sams, K. L.; Singh, L.; Seiz, E.; Bourgikos, E.; Vogels, C. B. F.; Ciota, A.; Schnurr, V.; Grenier, J. K.; Berthet, X.; Bento, A. I.; Harrington, L. C.; Diuk-Wasser, M.; Olarte-Castillo, X.; Goodman, L. B.
10.1101/2025.06.08.658352 — microbiology — Posted on 2025-06-08
3236 Preliminary insights into salivary proteomic versus targeted biomarker profiles associated with acute physical fatigue
Lindsey, B.; Bowden, K.; Shaul, Y.; Petricoin, E.; Caswell, S. V.; Alhammad, R.; Elayadi, A. N.; Martin, J.
10.1101/2025.06.04.657971 — physiology — Posted on 2025-06-08
3237 Complex rheology of condensin in entangled DNA
Conforto, F.; Valdes, A.; Vanderlinden, W.; Michieletto, D.
10.1101/2025.06.04.657969 — biophysics — Posted on 2025-06-08
3241 Stress-Induced Alteration of Small Extracellular Vesicles Drives Amyloid-Beta Sequestration and Exacerbates Alzheimer's Disease Pathogenesis
Zehra, S.; Rai, S.; Rani, K.; Choudhury, S. D.; Rai, H.; Bhowmik, S.; Mohan, N.; Gupta, A.; Chatterjee, P.; Reddy, T. J.; Rani, N.; Modi, G. P.; Nikolajeff, F.; Kumar, S.
10.1101/2025.05.23.655679 — neuroscience — Posted on 2025-06-08
3243 PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP
Wang, J.; Shi, Y.; Wang, Y.; Shen, Y.; Liu, H.; Sun, S.; Wang, Y.; Zhou, X.; Zhou, Y.; Zeng, X.; Li, J.; Chen, Q.
10.1101/2024.07.23.604769 — cancer biology — Posted on 2025-06-08
3245 Killer Toxin K28 resistance in yeast relies on COG complex mediated trafficking of the defence factor Ktd1
Laidlaw, K.; Nadir, H.; Milburn, A.; Cruz, M.; Stanislovas, J.; Droop, A.; MacDonald, S.; Andreev, I.; Leech, A.; Ungar, D.; Sadhu, M. J.; MacDonald, C.
10.1101/2024.12.20.629825 — cell biology — Posted on 2025-06-08
3246 Co-release of opposing signaling molecules controls the escalation and release of aggression
Gatlin, R. E.; Gagon, J.; Kwak, D.; Park, S.; Walker, H.; Kroheim, L.; Everett, T.; Covington, A.; Fluck, M. M.; Zickmund, T.; Frost, N. A.; Zelikowsky, M.
10.1101/2025.03.13.643119 — neuroscience — Posted on 2025-06-08
3247 Convergent and divergent brain-cognition relationships during development revealed by cross-sectional and longitudinal analyses in the ABCD Study
Xie, Y.; Zhang, S.; Orban, C.; Ooi, L. Q. R.; Kong, R.; Floris, D. L.; Zuo, X.-N.; Dhamala, E.; Holmes, A. J.; Uddin, L. Q.; Nichols, T. E.; Di Martino, A.; Yeo, B. T. T.
10.1101/2025.06.06.658294 — neuroscience — Posted on 2025-06-08
3253 Chromosome-length genome assembly of Uta stansburiana and gene expression data reveal fast pace-of-life comes with environmental stability
Fellows, S.; Araya-Donoso, R.; Davalos-Dehullu, E.; Khan, R.; Weisz, D.; Dudchenko, O.; Aiden, E. L.; Munguia-Vega, A.; Dolby, G. A.; Edwards, D. L.
10.1101/2025.05.28.656178 — evolutionary biology — Posted on 2025-06-08
3256 Genetic modulation of immune gene co-expression in the aged mouse hippocampus by the Apbb1ip locus
Tomkins, J. E.; Methi, A.; Bouland, G.; Doludda, B.; Murphy, K.; Miller, J. A.; Overall, R. W.; Mozhui, K.
10.1101/2025.06.04.657838 — bioinformatics — Posted on 2025-06-08
3259 Direct electrical stimulation of the human amygdala enhances recognition memory for objects but not scenes
Wahlstrom, K. L.; Campbell, J. M.; Hollearn, M. K.; Swift, J.; Adamek, M.; Blanpain, L.; Xie, T.; Davis, T.; Brunner, P.; Hamann, S. B.; Arain, A.; Eisenman, L.; Rolston, J. D.; Rahimpour, S.; Manns, J. R.; Willie, J. T.; Inman, C. S.
10.1101/2025.06.05.658078 — neuroscience — Posted on 2025-06-07
3261 Ketogenic diet dampens excitatory neurotransmission by shrinking synaptic vesicle pools
Stunault, M. I.; Deng, P.; Periandri, E. M.; Vitorino, F. N.; Barfield, A. J.; Ponce, R. J.; Garcia, B. A.; Egervari, G.; Klyachko, V. A.; Ashrafi, G.
10.1101/2025.06.04.657883 — neuroscience — Posted on 2025-06-08
3262 RNA Dynamics Regulate Transcriptional Condensate Vivacity to Drive Gene Coordination
Ogami, K.; Zheng, M. M.; Yoshino, S.; Sugimoto, Y.; Seida, M.; Mori, T.; Yoshizawa, R.; Onimaru, K.; Kadota, M.; Kuraku, S.; Suzuki, K. G. N.; Cisse, I. I.; Sharp, P. A.; Suzuki, H. I.
10.1101/2025.06.06.658161 — molecular biology — Posted on 2025-06-07
3264 Engineering lung-sensing T cells using synthetic receptors targeting RAGE
Jacob, A.; Whitty, C.; Lupica, G.; Badwal, E.; Ren, X.; Qiu, W.; Yu, W.; Tonai, Y.; Camara Serrano, J. A.; Simic, M.; Lim, W. A.; Allen, G.; Sheppard, D.
10.1101/2025.06.06.658315 — synthetic biology — Posted on 2025-06-07
3265 Integrated Histology and Molecular Profiling of Postmortem Human Auditory and Vestibular Organs via a Poly(Methyl Methacrylate)-Based Workflow
Baechinger, D.; Peyton, B.; Neubauer, J.; Dharmarajan, A.; Zhu, M.; O'Malley, J. T.; Kallupurackal, V.; Senese, S.; Brown, A.; Wunderlin, S.; Kreutzer, S.; Weiss, N. M.; Richter, H.; Dalbert, A.; Roeoesli, C.; Kipar, A.; Varga, Z.; von Rechenberg, B.; Amr, S.; Eckhard, A. H.
10.1101/2025.06.04.657716 — pathology — Posted on 2025-06-07
3266 Synthetic cargo adaptors reveal molecular features that can enhance dynein activation
Siva, A.; Gillies, J. P.; de Borchgrave, A.; Garrott, S. R.; Mishra, R.; El Jbeily, R.; Clarke, R.; Conklin, C.; Gibson, D.; Zang, J. L.; DeSantis, M. E.
10.1101/2025.06.06.658359 — biophysics — Posted on 2025-06-07
3267 Lizards on a sky archipelago: Genomic approaches to the evolution of the mountain genus Iberolacerta
Talavera, A.; Burriel-Carranza, B.; Mochales-Riano, G.; Estarellas, M.; Arribas, O.; Tejero-Cicuendez, H.; Salces-Ortiz, J.; Fernandez-Guiberteau, D.; Amat, F.; Niell, M.; Fernandez, R.; Mikheyev, A. S.; Carranza, S.
10.1101/2025.06.04.657811 — genomics — Posted on 2025-06-07
3269 Variation in inbreeding depression within and among Caenorhabditis species
Rockman, M. V.; Bernstein, M. R.; Caglar, D.; Cattani, M. V.; Chang, A. S.; Kaur, T.; Noble, L. M.; Paaby, A. B.
10.1101/2025.06.04.657873 — evolutionary biology — Posted on 2025-06-07
3274 Targeting Langerhans cells using a modular mannosylated nucleic acid-based vaccine platform
Vinther, S. C.; Resag, A.; Le, K. T. T.; Zelle-Rieser, C. C.; Strandt, H.; Malle, M. G.; Christiansen, S. H.; Del Frari, B.; Stigger, T.; Schilling, B.; Wohlfarth, J.; Thiel, S.; Valero, J.; Stoitzner, P.; Kjems, J.
10.1101/2025.06.04.657560 — molecular biology — Posted on 2025-06-07
3275 MRTF-dependent cytoskeletal dynamics drive efficient cell cycle progression
Nielsen, J. C.; Benito-Jardon, M.; Petrela, N. C.; Diring, J.; Bellamy, S.; Treisman, R.
10.1101/2025.06.06.657372 — molecular biology — Posted on 2025-06-07
3276 H3K4me1 directs H3K36me2 and H3K36me3 deposition in land plants
Wu, J.; Wang, J.; Du, K.; Li, Y.; Xie, W.; He, C.; Xing, Q.; Li, X.; Zhu, X.; Wu, Z.; Wu, X.; Shen, W.-H.; Lan, F.; Gan, J.; Liu, B.; Dong, A.
10.1101/2025.06.06.658275 — molecular biology — Posted on 2025-06-07
3278 BARTharm: MRI Harmonization Using Image Quality Metrics and Bayesian Non-parametric
Prevot, E.; Haering, D. A.; Gaetano, L.; Shinohara, R. T.; Holmes, C.; Nichols, T. E.; Ganjgahi, H.
10.1101/2025.06.04.657792 — neuroscience — Posted on 2025-06-07
3282 VesicleVoyager: In vivo selection of surface displayed proteins that direct extracellular vesicles to tissue-specific targets
Kawai-Harada, Y.; Mardikoraem, M.; Makela, A. V.; Lauro, K.; Lam, J.; Contag, C. H.; Woldring, D. R.; Harada, M.
10.1101/2025.06.04.657858 — bioengineering — Posted on 2025-06-07
3283 YAP/TAZ mechanotransduction is a fast cellular response to subnuclear adhesions revealed by mechanically dynamic substrates
Gandin, A.; Torresan, V.; Pelosin, M.; Vanni, G.; Busetto, R.; Citron, A.; Suli, A.; Panciera, T.; Zanconato, F.; Piccolo, S.; Brusatin, G.
10.1101/2025.06.04.656127 — bioengineering — Posted on 2025-06-07
3284 rtmsEcho: An Open-Source R Package for Automated Analysis of Acoustic Ejection Mass Spectrometry Data
Rimmer, M. A.; Twarog, N. A.; Ranathunge, T.; Wang, J.; Li, Y.; Chen, T.; Shelat, A.; Yang, L.
10.1101/2025.06.05.658081 — biochemistry — Posted on 2025-06-07
3285 A secreted fatty acid- and retinol- binding protein from Heligmosomoides polygyrus suppresses host macrophage polarization
Azizpor, P.; Montoya, J.; Eyabi, F.; Ramirez, J.; Hill, T.; Pena, R.; Mishra, M.; Boulanger, M.; Dillman, A. R.
10.1101/2025.06.05.657999 — biochemistry — Posted on 2025-06-07
3287 STARR-CRAAVT: A platform to design cell type-specific regulatory elements for next-generation gene therapy
Becker, R.; Choudhury, P.; Oti, M.; Fouani, Y.; Strobel, B.; Ketterer, S.; Rumpel, S.; Park, J.; Kreuz, S.; Maier, U.; Michelfelder, S.; Schön, C.
10.1101/2025.06.04.657008 — genomics — Posted on 2025-06-07
3288 The SAMM50 rs3761472 causes mitochondrial dysfunction and metabolic dysfunction-associated steatotic liver disease
Shin, H. Y.; Kim, S.; Kim, N.; Kim, U.; Kim, Y. J.; Yun, J. H.; Heo, J.; Lee, H.; Choi, J.; Jeong, I.; Kim, B.-J.
10.1101/2025.06.04.657815 — genetics — Posted on 2025-06-07
3289 Quantitative Assessment of Protein-DNA Interactions via SYBR Green Fluorescence
Wang, J.; Wang, J.; Wang, Z.; Wang, P.; Sun, S.; Li, X.; Tian, Z.; Xu, R.; Shi, Y.; Wang, Y.
10.1101/2025.06.06.658291 — molecular biology — Posted on 2025-06-07
3290 A novel Notch and WNT signaling mechanism contribute to pediatric DCM: a pathway to new therapeutics.
Nyarko, O. O.; Rausch, E.; Goff, J. R. H.; Karimpour-Fard, A.; Conard, C. S.; Hernandez-Lagunas, L.; Burns, M. P. A.; Pena, B.; Miyamoto, S. D.; Stauffer, B. L.; Sucharov, C. C.
10.1101/2025.06.07.658396 — molecular biology — Posted on 2025-06-07
3291 Regulation of essential hepatocyte functions and identity by super-enhancers in health and disease
Lin, T.; Huang, C.; Tong, C.; Xu, W.; Wang, H.; Wu, S.; Zhang, W.; Li, Y.; Liu, H.; Shao, C.; Liu, R.; Wang, S.; Munker, S.; Niess, H.; Meyer, C.; Liebe, R.; Ebert, M.; Gao, C.; Dooley, S.; Ding, H.; Zuo, L.; Wang, H.; Weng, H.
10.1101/2025.06.04.657826 — molecular biology — Posted on 2025-06-07
3293 Advancing Ligand Binding Affinity Prediction with Cartesian Tensor-Based Deep Learning
Yu, J.; Sheng, X.; Fan, Z.; Wang, Z.; Cao, D.; Hao, Y.; Zhang, Y.; rao, J.; Shao, P.; Chen, M.; Chen, K.; Teng, D.; Luo, X.; Zhang, S.; Zheng, M.
10.1101/2025.06.04.657800 — molecular biology — Posted on 2025-06-07
3297 Identification and biosynthesis of xildivaline, a novel and widespread peptide deformylase inhibitor from Gammaproteobacteria
Rill, A.; Westphalen, M.; Lamberioux, M.; Chekaiban, J.; Janin, C.; Mazel, D.; Groll, M.; Huber, E. M.; Bode, H. B.
10.1101/2025.06.07.658423 — microbiology — Posted on 2025-06-07
3298 Functional immune profiling reveals CD4+ T cell dysregulation associated with celiac disease
Farchione, A. J.; Cheon, H.; Vremec, D.; Neumann, J.; Verstappen, G. M.; Hardy, M. Y.; Margetts, M. B.; Howson, L. J.; Henneken, L. M.; Ford, M.; Tye-Din, J. A.; Heinzel, S.; Hodgkin, P. D.; Bryant, V. L.
10.1101/2025.06.06.658209 — immunology — Posted on 2025-06-07
3301 Mini-bacterioferritins: Structural insight into a new type of ferritin-like protein from an anaerobic methane-oxidising archaeon
Wissink, M.; Engilberge, S.; Leao, P.; Jansen, R. S.; Jetten, M. S. M.; Royant, A.; Welte, C. U.; Wagner, T.
10.1101/2025.06.06.658376 — biochemistry — Posted on 2025-06-07
3302 Improved EPR sensitivity for aqueous biological samples using low-volume multi-channel cells and dielectric resonators
Mett, R. R.; Anilkumar, A.; Garces, A. M.; Wehrley, J. T.; Klug, C. S.; Lerch, M. T.; Sidabras, J. W.
10.1101/2025.06.03.657726 — biophysics — Posted on 2025-06-07
3307 Parallel evolution of plant alkaloid biosynthesis from bacterial-like decarboxylases
Wood, C. X.; Jiang, Z.; Amarnath, I.; Waddell, L. J. N.; Batey, U. S.; Serna Daza, O.; Newling, K.; James, S.; Grogan, G.; Unsworth, W. P.; Lichman, B. R.
10.1101/2024.06.04.597157 — biochemistry — Posted on 2025-06-07
3309 Hippocampal reactivation of aversive experience enables safety learning and slow-breathing state for recovery from stress
Maheo, B.; Bagur, S.; Bryzgalov, D.; Hayhurst, C.; Chouvaeff, M.; Callas, E.; Carole, S.; Gallopin, T.; Benchenane, K.
10.1101/2025.06.03.657500 — neuroscience — Posted on 2025-06-07
3312 Cardiorespiratory mechanisms triggered during music perception in preterm infants and adults
Lavezzo, L.; Barcos-Munoz, F.; Benis, D.; Margaria, J.; Grandjean, D.; Scilingo, E. P.; Vollenweider, A.; Henriot, S.; Nardelli, M.; Hüppi, P.; Filippa, M.
10.1101/2025.06.03.657691 — physiology — Posted on 2025-06-07
3313 Proteomic characterization of major fish allergy responsive protein parvalbumins in Hilsa (Tenualosa ilisha): A commercially important fish in Southeast Asia
Shaheen, N.; Peng, Z.; Singh, A.; Wahab, A.; Gasset, M.; Islam, M. H.; Halima, O.; Ali, A. F.; Shah, S. M.; Salkini, M.; Saleemi, S.; Mallah, A. M.; Khan, A.; Mesiya, S.; Khandaker, M.; Zarif, A.; Ali, A.; Samour, A.; Peters, J. W.; Ahsan, N.; Yang, Z.
10.1101/2025.06.03.657624 — biochemistry — Posted on 2025-06-07
3315 Substructure and maturation of lamina-associated domains in neurons of the developing and adult human brain
Zhang, C.; Gil, E.; Ahanger, S. H.; Li, M.; Wang, L.; Huang, E. J.; Li, J.; Kriegstein, A. R.; Lim, D. A.
10.1101/2024.11.27.625786 — genomics — Posted on 2025-06-07
3319 Stochastic Misfolding Drives the Emergence of Distinct α-Synuclein Strains
So, R. W. L.; Frieg, B.; Camino, J. D.; Silver, N. R. G.; Mao, A.; Stuart, E.; Schröder, G. F.; Watts, J. C.
10.1101/2025.06.03.657690 — neuroscience — Posted on 2025-06-07
3320 Mapping the Transcriptional Landscape of Drug Responses in Primary Human Cells Using High-Throughput DRUG-seq
Baugh, L.; Vigneau, S.; Sridhar, S.; Boswell, S.; Pilitsis, G.; Bradley, J.; Allen, O.; Rand, L.; Riccardi, A.; Roach, K.; Lema, K.; Ergun, A.
10.1101/2025.06.03.657593 — systems biology — Posted on 2025-06-07
3321 Maize root growth, Oxygen and N availability drive formation of N2O hotspots in soil
Rummel, P. S.; Rasmussen, M. R.; Saghai, A.; Merl, T.; Hallin, S.; Mueller, C. W.; Koren, K.
10.1101/2025.06.03.657623 — plant biology — Posted on 2025-06-07
3323 Parkinson's disease-vulnerable and -resilient dopamine neurons display opposite responses to excitatory input
Hadjas, L. C.; Kollman, G. J.; Linderhof, L.; Xia, M.; Mansur, S.; Saint-Pierre, M.; Lim, B.; Lee, E. B.; Cicchetti, F.; Awatramani, R.; Hollon, N. G.; Hnasko, T. S.
10.1101/2025.06.03.657460 — neuroscience — Posted on 2025-06-07
3326 Multimodal layer-crossing interrogation of brain circuits enabled by microfluidic axialtrodes
Sui, K.; Codadu, N. K.; Rathore, D.; Li, G.; Meneghetti, M.; Bocker, A. L.; Berg, R. W.; Wykes, R. C.; Markos, C.
10.1101/2024.10.18.619110 — neuroscience — Posted on 2025-06-07
3327 Human PAR1 expressed on mouse platelets contributes to hemostasis and arterial occlusion
Kanaji, S.; Zarpellon, A.; Aiolfi, R.; Morodomi, Y.; Orje, J.; Zampolli, A.; Won, E.; Ruggeri, Z. M.; Kanaji, T.
10.1101/2025.06.03.657740 — physiology — Posted on 2025-06-07
3328 HNF4α controls growth, identity and response to KRAS inhibition of invasive mucinous adenocarcinoma of the lung
Essel Dadzie, H.; Green, Y. S.; Camolotto, S.; Gumbleton, M.; Maeda, Y.; Spike, B. T.; Snyder, E. L.
10.1101/2025.06.06.658155 — cancer biology — Posted on 2025-06-07
3329 DNA Partitioning Modulates Liquid-to-Solid Transitions and the Internal Microstructure of FUS Condensates
Ilhamsyah, D.; Luong, C.; Qamar, S.; St George-Hyslop, P.; Ju, L. A.; Mackay, J.; Knowles, T.; Vigolo, D.; Shen, Y.
10.1101/2025.06.03.657213 — biophysics — Posted on 2025-06-07
3330 Single-cell transcriptomic integrated with machine learning reveals retinal cell-specific biomarkers in diabetic retinopathy
LIN, S.; Yang, L.; TAO, Y.; PAN, Q.; CAI, T.; Ye, Y.; Liu, J.; Zhou, Y.; Shao, Y.; Yi, Q.; Lu, Z. H.; Chen, L.; McKay, G.; Rankin, R.; Li, F.; Meng, W.
10.1101/2025.06.03.657753 — bioinformatics — Posted on 2025-06-07
3333 Microbiome composition shapes temperature tolerance in a Hawaiian picture-winged Drosophila
Price, D. K.; West, K.; Cevallos-Zea, M.; Cahan, S.; Longman, E.; Nunez, J. C. B.; Yew, J.; Mederios, M. J.
10.1101/2025.06.03.657679 — evolutionary biology — Posted on 2025-06-07
3334 Lack of mRNA Methylation in Schwann Cells Results in Demyelination and Regenerative Failure
Sari, M. C.; Johnson, A.; Yu, A. T.; Mi, R.; Chen, W.; Hu, X.; Harris, T. G.; Tuffaha, S.; Swarup, V.; Kawaguchi, R.; Ming, G.-L.; Hoke, A.
10.1101/2025.06.03.657089 — neuroscience — Posted on 2025-06-07
3336 Respiratory coordination of excitability states across the human wake-sleep cycle
Sanchez Corzo, A.; Bullon Tarraso, E.; Saltafossi, M.; Berther, T.; Staudigl, T.; Kluger, D. S.; Schreiner, T.
10.1101/2025.06.03.657770 — neuroscience — Posted on 2025-06-07
3337 Impairment in axonal translation and cytoplasmic viscosity during aging in sensory neurons
Emily, M. F.; Guillaud, L.; De la Fuente Ruiz, S.; Agrawal, R.; Boerner, S.; Akimoto, Y.; Turkki, T. H.; Rosti, M. E.; Terenzio, M.
10.1101/2025.06.03.657746 — neuroscience — Posted on 2025-06-07
3339 Paracrine Signals from HIV-1 Infected Immune Cells Reprogram Cervical Cancer Pathways
Olwal, C. O.; Rathore, U.; Makanani, S.; Kaushal, P.; Ashley, I. A.; Ummadi, M. R.; Appiah, V.; Djomkam Zune, A. L.; Blanc, S.; Winters, D.; Delgado, Y.; Muthoka, K.; Fabius, J. M.; Eckhardt, M.; Kaake, R. M.; Su, M.; Fregoso, O. I.; Hultquist, J. F.; Orango, E. O.; Swaney, D. L.; Kyei, G. B.; Krogan, N. J.; Quashie, P. K.; Bediako, Y.; Bouhaddou, M.
10.1101/2025.06.06.658239 — cancer biology — Posted on 2025-06-07
3343 Examining the Role of Extrachromosomal DNA in 1,216 Lung Cancers
Khandekar, A.; Hoang, P. H.; Luebeck, J.; Diaz-Gay, M.; Zhao, W.; McElderry, J. P.; Hartman, C.; Miraftab, M.; Lee, O. W.; Barnao, K. M.; Bergstrom, E. N.; Yang, Y.; Nowak, M. A.; Rothman, N.; Homer, R.; Yang, S.-R.; Lan, Q.; Wedge, D. C.; Yang, L.; Chanock, S. J.; Zhang, T.; Alexandrov, L. B.; Landi, M. T.
10.1101/2025.06.03.657117 — bioinformatics — Posted on 2025-06-07
3346 Intraspecific variation in the duration of epigenetic inheritance
Frejacques, F.; Saglio, M.; Aljohani, M.; Froekjaer-Jensen, C.; Frezal, L.; Felix, M.-A.
10.1101/2025.06.04.657799 — evolutionary biology — Posted on 2025-06-07
3348 Heme-Mediated Selection of Encapsulated Streptococcus pneumoniae in the Lungs by Oxidative Stress
Alibayov, B.; Jop Vidal, A. G.; Murin, L.; Scasny, A.; Takeshita, K.; Beaton, K.; Edwards, K.; Punshon, T.; Jackson, B.; McDaniel, L. S.; Vidal, J. E.
10.1101/2023.11.14.567109 — microbiology — Posted on 2025-06-07
3350 Inhibiting RhoA Activation via GDP-state Stabilization to Relieve Heart Failure
Xue, M.; Liang, Y.; Yuan, Z.; Liu, X.; Chang, L.; Wang, Y.; Xu, P.; Zhang, T.; Jiang, H.; Zhao, Z.; Liu, J.; Ruan, S.; Ye, T.; Pang, X.; Mei, W.; Wang, J.; Sun, X.; Wang, H.; Cui, J.; Zu, Y.; Lin, X.; Zhao, Z.; Wang, R.; Huang, H.; Luo, C.; Tao, S.; Wang, J.; Duan, Y.; Zhu, L.; Tang, H.; Zhang, J.; Wang, Y.; Li, C.; Li, H.
10.1101/2025.06.03.657556 — pharmacology and toxicology — Posted on 2025-06-07
3351 Integrative analysis of mRNA stability regulation uncovers a metastasis-suppressive program in breast cancer
Karner, H.; Mittmann, T. C.; Chen, V. W.; Borah, A. A.; Langen, A.; Yousefi, H.; Fish, L.; Zaro, B. W.; Navickas, A.; Goodarzi, H.
10.1101/2025.06.06.658309 — cancer biology — Posted on 2025-06-07
3352 TRPV4 Channels Mediate Bladder Cancer Cell Proliferation, Migration and Chemoresistance
Katari, V.; Dalal, K.; Kondapalli, N.; Paruchuri, S.; Nadiminity, N.; Thodeti, C.
10.1101/2025.06.05.657842 — cancer biology — Posted on 2025-06-07
3353 Acid ceramidase inhibition enhances BCL-2 targeting in venetoclax-resistant acute myeloid leukemia via a cytotoxic integrated stress response
Ung, J.; Tan, S.-F.; Shaw, J. J.; Taori, M.; Deddens, T. M.; Venancio, G. d. C.; Montgomery, M. M.; Hagen, J. T.; Aruleba, R. T.; Golla, U.; Sharma, A.; Paudel, B. B.; Lee, I. S.-A.; Ramamoorthy, B.; Janes, K. A.; Garrett-Bakelman, F. E.; Cabot, M. C.; Fisher-Wellman, K. H.; Fox, T. E.; Claxton, D. F.; Chalfant, C. E.; Feith, D. J.; Loughran, T. P.
10.1101/2025.06.06.657881 — cancer biology — Posted on 2025-06-07
3354 Pancreatic cancer cachexia is mediated by PTHrP-driven disruption of adipose de novo lipogenesis
Bhalerao, N. U.; Ogoti, Y.; Peura, J.; Johnson, C.; Chen, Q.; Korobkina, E.; Keller, F.; Wengyn, M.; Norgard, R. J.; Shamber, C.; Klute, K.; DiMaio, D.; Sellin, K.; Grandgenett, P. M.; Li, R.; Hollingsworth, M. A.; GUILHERME, A.; Czech, M.; Kremer, R.; Zhu, L. J.; Watson, E. V.; Ruscetti, M.; Guertin, D.; Pitarresi, J. R.
10.1101/2025.06.03.657464 — cancer biology — Posted on 2025-06-07
3355 Dietary lipids, not ketone body metabolites, influence intestinal tumorigenesis in a ketogenic diet
Shay, J. E. S.; Chi, F.; Tzouanas, C. N.; Hoeve-Scott, J. T.; Williams, K. J.; Sever, T.; Fuentes, I.; Yilmaz, O. H.
10.1101/2025.06.06.658169 — cancer biology — Posted on 2025-06-07
3358 Multimodal profiling unveils a reversible basal-like breast cancer cell state resistant to AKT inhibition
Ratcliffe, C. D. H.; Sparks, H.; Boezio, G. L. M.; Alexandrov, Y.; Jenkins, R. P.; Le Marois, A.; Soro-Barrio, P.; Lee, R.; Strohbuecker, S.; Joshi, S.; Ellis, J. K.; Fortier, A.-M.; Gustafsson, N.; Cunha, A. C.; Park, M.; MacRae, J. I.; Serio, A.; Briscoe, J.; Riddell, A.; Barry, S. T.; Dunsby, C.; Sahai, E.
10.1101/2025.06.06.658331 — cancer biology — Posted on 2025-06-07
3359 Modeling acquired TKI resistance and effective combination therapeutic strategies in murine RET+ lung adenocarcinoma
Hinz, T. K.; Le, A. T.; Doan, T.; Ast, A.; Jaramillo, S.; Haines, S.; Navarro, A.; Patil, T.; Nemenoff, R. A.; Heasley, L. E.
10.1101/2025.06.04.657911 — cancer biology — Posted on 2025-06-07
3360 Assessing target genes for homing suppression gene drive
Xu, X.; Fang, J.; Chen, J.; Yang, J.; Yang, X.; Hou, S.; Sun, W.; Champer, J.
10.1101/2024.12.06.627146 — genetics — Posted on 2025-06-07
3362 Live-cell analyses with unsegmented images to study cancer cell response to modified T cell therapy
Epstein, L.; Weiner, A. C.; Verma, A.; Saedi, M.; Carnevale, J.; Marson, A.; Engelhardt, B. E.
10.1101/2025.06.04.657687 — cancer biology — Posted on 2025-06-07
3363 Dual inhibition of EGFR and PI3Kinase signaling in EGFR amplified triple negative breast cancer cells induces apoptosis and reduces tumor growth
Wisniewski, D. J.; Voeller, D.; Addissie, Y. A.; Deshmukh, S. K.; Wangsa, D.; Wangsa, D.; Heselmeyer-Haddad, K.; Wu, S.; Lustberg, M. B.; Sledge, G. W.; Lipkowitz, S.
10.1101/2025.06.03.657674 — cancer biology — Posted on 2025-06-07
3366 A multi-step immune-competent genetic mouse model reveals phenotypic plasticity in uveal melanoma
Xu, X.; Liu, X.; Dollar, J.; Liu, X.; Jasani, N.; Posorske, B.; Sriramareddy, S. N.; Jarajapu, V.; Kuznetsoff, J. N.; Sinard, J.; Bennett, R. L.; Licht, J.; Smalley, K.; Harbour, J. W.; Yu, X.; Karreth, F. A.
10.1101/2025.06.04.657841 — cancer biology — Posted on 2025-06-07
3368 LSH-mediated resolution of R-loops mitigates transcription-replication conflicts to preserve genomic stability in prostate cancer cells
Ni, K.; Zhang, Y.; Zheng, K.; Huang, J.; Xiong, N.; Liang, R.; Chen, Y.; Jin, H.; Hai, Y.; Li, W.; Ma, J.; Yang, R.; Xia, G.; Bai, Y.; Song, L.; Hu, X.; Tang, Z.; Fu, Q.
10.1101/2025.06.04.657812 — cancer biology — Posted on 2025-06-07
3369 Notch3 regulates pericyte phenotypic plasticity in colorectal cancer
Koliaraki, V.; Chalkidi, N.; Stavropoulou, A.; Arvaniti, V. Z.; Paraskeva, C.; Monogyiou, A.; Sakkou, M.; Nikolaou, C.
10.1101/2025.06.04.657823 — cancer biology — Posted on 2025-06-07
3370 Tumor-Educated-Platelets interact with Breast Cancer-Stem-Cells via P-selectin- PSGL1 and ensure stemness and metastasis through WNT-β-Catenin-VEGF-VEGFR2 intra-cellular signaling: Therapeutic modulation by aspirin
Guha, A.; Sultana, J.; Bhuniya, A.; Chakravarti, M.; Bera, S.; Sarkar, A.; Dhar, S.; Roy Choudhury, P.; Das, J.; Ganguly, N.; Guha, I.; Das, T.; Alam, N.; Ghosh, I.; Hajra, S.; Baral, R.; Bose, A.; Banerjee, S.
10.1101/2025.06.04.657784 — cancer biology — Posted on 2025-06-07
3371 LIMD1 Loss Confers a GPX4-Dependent Cell State in Lung Cancer
Saha, A.; Grevitt, P.; Marques, J. G.; Von Kriegsheim, A.; Shah, K. M.; Gao, Z.; Stockwell, B. R.; Finch, A. J.; Peck, B.; Sharp, T. V.
10.1101/2025.06.06.658274 — cancer biology — Posted on 2025-06-07
3375 Calcium Dependent Conformational Changes in Human Transglutaminase 2 and its Implications in Celiac Disease
Srikanth, S.; Karthikeyan, P. P.; Sezen, M.; Sridhar, D. K.; Doppalapudi, K.; Sen, T. Z.; Ulaganathan, V.; Yennamalli, R. M.
10.1101/2025.06.04.657948 — bioinformatics — Posted on 2025-06-07
3377 Loss of endothelial ALK1 signaling induces the emergence of a KIT+ angiogenic endothelial cluster driving brain arteriovenous malformations
Drape, E.; Carrier, L.; Cagnone, G.; Drissi Touzani Walali, H.; Bizou, M.; Van Vliet, P. P.; Andelfinger, G.; Larrivee, B.; Dubrac, A.
10.1101/2025.06.05.657957 — cell biology — Posted on 2025-06-07
3379 Analysis of Essential Genes in Clostridioides difficile by CRISPRi and Tn-seq
Alberts, M.; Kurtz, M.; Müh, U.; Bernardi, J.; Bollinger, K.; Duncan, L.; Dobrila, H. A.; Laster, H.; Orea, A.; Pannullo, A.; Rivera-Rosado, J.; Torres, F.; Ellermeier, C. D.; Weiss, D. S.
10.1101/2025.06.04.657922 — microbiology — Posted on 2025-06-07
3380 Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically-diverse Caenorhabditis nematodes
Banse, S. A.; Sedore, C. A.; Coleman-Hulbert, A.; Johnson, E.; Onken, B.; Hall, D.; Segerdell, E.; Jackson, E. G.; Song, Y.; Osman, H. C.; Xue, J.; Basttistoni, E.; Guo, S.; Foulger, A.; Achanta, M.; Sheikh, M.; Fitzgibbon, T.; Willis, J. H.; Woodruff, G. C.; Driscoll, M.; Lithgow, G.; Phillips, P. C.
10.1101/2024.10.23.619838 — genetics — Posted on 2025-06-07
3381 Intestinal Stem Cells from Patients with Inflammatory Bowel Disease Retain an Epigenetic Memory of Inflammation
Hamdan, F. H.; Perez, I.; Kossick, K.; Smith, H.; Edwinson, A.; de Hoyos-Vega, J. M.; Gonzalez, M.; Chiang, D.; Klatt, E.; Rumer, K.; Perez Pachon, M.; Sagstetter, M.; Friton, J.; Kammer, E.; English, A.; Chini, L. C. S.; Carnahan, J. F.; Baca, N. A.; Mopuri, R.; Bhagwate, A.; Raffals, L. E.; Sun, Z.; Grover, M.; Revzin, A.; Faubion, W. A.; Druliner, B. R.
10.1101/2025.05.24.655923 — molecular biology — Posted on 2025-06-07
3382 TICKHUNTER: A Targeted Hybridization-Capture Sequencing Approach for the Detection and Characterization of Tick-borne Pathogens and Blood Meals
Wang, X.; Brown, J. J.; Lilly, M. V.; Plimpton, L.; Murrell, C. M.; Llanos-Soto, S. G.; Zehr, J. D.; Sun, Y.; Reboul, G.; Sams, K.; Sabaawy, A.; Singh, L.; Tallmadge, R. L.; Mitchell, P. K.; Anderson, R. R.; Ladd-Wilson, S. G.; Bourgikos, E.; Vogels, C. B.; Olarte-Castillo, X. A.; Diuk-Wasser, M.; Goodman, L. B.
10.1101/2025.06.06.658355 — microbiology — Posted on 2025-06-07
3386 Stress induces distinct social behavior states encoded by the ventral hippocampus
Sattler, K. P.; Conoscenti, M. A.; Hedges, A.; Ortega, J.; Miller, R.; Owen, E.; Hanson, R.; Zelikowsky, M.
10.1101/2025.06.06.658117 — neuroscience — Posted on 2025-06-07
3387 Neural coding of spectrotemporal modulations in the auditory cortex supports speech and music categorization
Ginzburg, J.; Debaque, E. C.; Borderie, A.; Morillon, B.; Martineau, L.; Bonaventure, P. L.; Zatorre, R. J.; Albouy, P.
10.1101/2025.06.05.657930 — neuroscience — Posted on 2025-06-07
3388 Causal Lesion Evidence for Two Motor Speech Coordination Networks in the Brain
Burns, W.; Strawderman, E.; Meyers, S. P.; Schmidt, T.; Walter, K. A.; Pilcher, W. H.; Mahon, B. Z.; Garcea, F. E.
10.1101/2025.06.05.658124 — neuroscience — Posted on 2025-06-07
3389 Targeting Neutrophil Extracellular Traps to inhibit Colon Cancer Tumor Necrosis and Metastasis
Gazzara, E.; Adrover, J. M.; Lui, A.; Han, S.; Aminzada, Z.; Bhandari, N.; Sivetz, N.; Shirue, V. S.; Shergill, B. S.; Curtis, M. B.; George, S. C.; Cicala, A.; Rishi, A.; Chung, C.; Devoe, C.; Huang, H.; Weiss, M.; Lou, E.; Tuveson, D. A.; Beyaz, S.; Westcott, P. M. K.; Egeblad, M.; Gholami, S.
10.1101/2025.05.30.657122 — cancer biology — Posted on 2025-06-07
3390 Automatic Phenotyping Using Exhaustive Projection Pursuit
Moore, W. A.; Meehan, S. W.; Meehan, C.; Parks, D. R.; Walther, G.; Herzenberg, L. A.
10.1101/2024.11.20.624581 — bioinformatics — Posted on 2025-06-06
3391 The flexible stalk domain of sTREM2 modulates its interactions with brain-based phospholipids
Saeb, D.; Lietzke, E. E.; Fuchs, D. I.; Aldrich, E. C.; Bruce, K. D.; Sprenger, K. G.
10.1101/2024.09.04.611223 — bioengineering — Posted on 2025-06-07
3396 Human genetic ancestry, Mycobacterium tuberculosis diversity and tuberculosis disease severity in Dar es Salaam, Tanzania
Zwyer, M.; Xu, Z. M.; Ross, A.; Hella, J.; Sasamalo, M.; Rotival, M.; Hiza, H.; Rutaihwa, L. K.; Borrell, S.; Reither, K.; Fellay, J.; Portevin, D.; Quintana-Murci, L.; Gagneux, S.; Brites, D.
10.1101/2024.08.10.607244 — evolutionary biology — Posted on 2025-06-06
3397 Developmentally cascading structures do not lose evolutionary potential, but compound developmental instability in rat molars
Vitek, N. S.; Saks, E.; Dong, A.; Burroughs, R.; Ward, D. L.; Pomeroy, E.; Martin-Gronert, M.; Ozanne, S. E.
10.1101/2025.01.13.632740 — evolutionary biology — Posted on 2025-06-07
3398 Ancestral splice variation is a substrate for rapid diversifcation in African cichlids
Singh, P.; Ahi, E. P.; Duenser, A.; Durdevic, M.; Gessl, W.; Schaeffer, S.; Seehausen, O.; Sturmbauer, C.
10.1101/2025.05.13.653813 — evolutionary biology — Posted on 2025-06-07
3401 Short-term management of kelp forests for marine heatwaves requires planning
Hopf, J. K.; Giraldo-Ospina, A.; Caselle, J. E.; Kroeker, K. J.; Carr, M. H.; Botsford, L. W.; Hastings, A.; White, J. W.
10.1101/2025.01.30.634607 — ecology — Posted on 2025-06-07
3403 Unbiased profiling of multipotency landscapes reveals spatial modulators of clonal fate biases
Erickson, A. G.; Isaev, S.; He, J.; Artemov, A. V.; Semsch, B.; Murtazina, A.; Sun, J.; Mangold, K.; Chalou, A.; Frisen, J.; Ratz, M.; Andersson, E. R.; Kharchenko, P. V.; Adameyko, I.
10.1101/2024.11.15.623687 — developmental biology — Posted on 2025-06-06
3404 miR-133a and miR-338-3p Shape Neural Crest Derivatives in Zebrafish
Steeman, T. J.; Weiner, A. M. J.; Rubiolo, J. A.; Sanchez, L. E.; Calcaterra, N. B.
10.1101/2025.06.06.658297 — developmental biology — Posted on 2025-06-07
3405 Plat safeguards maternally aged oocytes against programmed cell death through activating the Erk1/2 pathway
He, X.; Zhang, H.; Wang, Y.; Yan, H.; Chen, Q.; Su, M.; Shi, Q.; Zeng, X.; Sheng, W.; Wang, Y.; Wang, C.; Hou, S.; Hu, Z.; He, Y.; Wang, X.
10.1101/2025.02.11.637629 — developmental biology — Posted on 2025-06-07
3409 Deep learning recognises antibiotic modes of action from brightfield images
Krentzel, D.; Kho, K.; Petit, J.; Mahtal, N.; Chiaravalli, J.; Shorte, S. L.; Wehenkel, A. M.; Boneca, I. G.; Zimmer, C.
10.1101/2025.03.30.645928 — microbiology — Posted on 2025-06-07
3410 NEUROLINGUA: A Neuroimaging Database Tailored to Unravel the Complexity of Multilingual Comprehension
Quinones, I.; Carrion-Castillo, A.; Diez-Zabala, I.; de Frutos-Sagastuy, L.; Costello, B.; Carcedo, D.; Manso-Ortega, L.; Slivka, M.; Sanchez, A.; Schüller, A.; Caballero Gaudes, C.; Paz Alonso, P. M.; Carreiras, M.
10.1101/2025.06.06.658050 — neuroscience — Posted on 2025-06-06
3413 Central nervous system atlas of larval zebrafish constructed using the morphology of single excitatory and inhibitory neurons
Du, X.; Yue, Z.; Wei, J.; Li, W.; Chen, M.; Chen, T.; Hu, H.; Ren, H.; Jia, Z.; Ning, X.; Zhong, Y.; Zheng, X.; Wang, R.; Wan, H.; Zhao, T.; Jin, C.; Huang, J.; Shen, X.; Zheng, M.; Shen, X.; Qiu, X.; Zhang, W.; Zhao, Q.; Ma, Y.; Li, D.; Chen, L.; Wang, Y.; Wang, S.; Gong, Y.; Mu, Y.; Ji, P.; He, J.; Wang, Y.; Du, J.
10.1101/2025.06.06.658008 — neuroscience — Posted on 2025-06-06
3415 Synthetic Serum Markers Enable Noninvasive Monitoring of Gene Expression in Primate Brains
Lee, S.; Romac, M.; Watanabe, S.; Chernov, M.; Li, H.; Raisley, E.; Szablowski, J. O.; Costa, V. D.
10.1101/2025.06.01.657212 — neuroscience — Posted on 2025-06-06
3416 Convergent and divergent brain-cognition relationships during development revealed by cross-sectional and longitudinal analyses in the ABCD Study
Yeo, T.; Xie, Y.; Zhang, S.; Orban, C.; Ooi, L. Q. R.; Kong, R.; Floris, D. L.; Zuo, X.-N.; Dhamala, E.; Holmes, A. J.; Uddin, L. Q.; Nichols, T. E.; Di Martino, A.
10.1101/2025.06.06.658294 — neuroscience — Posted on 2025-06-07
3418 Cell-Cell Communication and Gene Regulation of Stem Cell-Parenchymal Cell Fusion
Nazaryabrbekoh, F.; Huang, J.; Shoaib, S. S.; Tang, X.; Kim, J.; Ogle, B. M.; Jung, J. P.
10.1101/2025.02.11.637745 — systems biology — Posted on 2025-06-06
3419 Protein phase change batteries drive innate immune signaling and cell fate
Rodriguez Gama, A.; Miller, T.; Venkatesan, S.; Lange, J. J.; Wu, J.; Song, X.; Bradford, W. D.; Cook, M.; Unruh, J. R.; Halfmann, R.
10.1101/2023.03.20.533581 — biophysics — Posted on 2025-06-06
3422 Dynamic strategic social learning in nest-building zebra finches and its generalisability
Breen, A. J.; Eckersley, T.; Camacho-Alpizar, A.; Lambert, C. T.; Balasubramanian, G.; Healy, S. D.; McElreath, R.; Guillette, L. M.
10.1101/2025.06.06.658225 — animal behavior and cognition — Posted on 2025-06-06
3424 Substructure and maturation of lamina-associated domains in neurons of the developing and adult human brain
Zhang, C.; Gil, E.; Ahanger, S. H.; Li, M.; Wang, L.; Huang, E. J.; Li, J.; Kriegstein, A. R.; Lim, D. A.
10.1101/2024.11.27.625786 — genomics — Posted on 2025-06-06
3426 Single-nucleus RNA sequencing reveals the cellular diversity of cerebrospinal fluid in the context of intraventricular hemorrhage
Malaiya, S.; Serra, R.; Cortes-Gutierrez, M.; Wilhelmy, B. E.; Jusuf, E.; Somalinga, M.; Peprah, D.; Nambiar, H.; Kim, K. T.; Saadon, J. R.; Patel, P. D.; Yarmoska, S. K.; Rakovec, M.; Kim, J.; Lei, C.; Panchagnula, S.; Ambrocio, R. E.; Cherney, M.; Ayithan, N.; Fan, X.; Gerzanich, V.; Simard, J. M.; Badjatia, N.; Schwartzbauer, G.; Parikh, G. Y.; Ament, S. A.; Ciryam, P.
10.1101/2025.06.05.657834 — genomics — Posted on 2025-06-06
3428 Phosphatidylethanolamine is a phagocytic ligand implicated in the binding and removal of apoptotic and microbial extracellular vesicles
Kavianpour, A.; Ghasempour, S.; Meyer, K. J.; Le, T.; Cai, R.; Marques, P. E.; Nodwell, J. R.; Freeman, S. A.
10.1101/2024.11.18.624161 — cell biology — Posted on 2025-06-06
3430 Cross-species Standardised Cortico-Subcortical Tractography
Assimopoulos, S.; Warrington, S.; Folloni, D.; Bryant, K.; Tang, W.; Jbabdi, S.; Heilbronner, S.; Mars, R. B.; Sotiropoulos, S. N.
10.1101/2025.04.29.651254 — neuroscience — Posted on 2025-06-06
3431 High frequency spike inference with particle Gibbs sampling
Diana, G.; Sermet, B. S.; DiGregorio, D. A.; Wang, S. S.; Broussard, G. J.
10.1101/2022.04.05.487201 — neuroscience — Posted on 2025-06-06
3435 BetaII-Spectrin Gaps and Patches Emerge from the Patterned Assembly of the Actin/Spectrin Membrane Skeleton in Human Motor Neuron Axons
Gazal, N. G.; Castellanos-Montiel, M. J.; Bruno, G.; Franco-Flores, A. K.; Lepine, S.; Gursu, L.; Haghi, G.; Maussion, G.; Anastasia, A.; Bisbal, M.; Gorostiza, E. A.; Durcan, T. M.; Unsain, N.
10.1101/2025.05.09.653215 — neuroscience — Posted on 2025-06-06
3436 Neural Adaptation to Expected Uncertainty in Neurotypical Adults and High-Functioning Adults with Autism Spectrum Disorder
Pultsina, K.; Kozunova, G.; Chernyshev, B.; Prokofyev, A.; Tretyakova, V.; Novikov, A.; Rytikova, A.; Stroganova, T.
10.1101/2025.03.30.646160 — neuroscience — Posted on 2025-06-06
3440 Mechanisms of 10-Hydroxyoctadecanoic acid resistance in Streptococcus pneumoniae
Johnson, C.; Frank, M. W.; Morrow, B. T.; Jia, Q.; Radka, C. D.; Rosch, J. W.
10.1101/2025.06.06.658354 — microbiology — Posted on 2025-06-06
3443 A multi-partner symbiotic community inhabits the emerging pest Pentastiridius leporinus
Vogel, H.; Weiss, B.; Rama, F.; Rinklef, A.; Engl, T.; Kaltenpoth, M.; Vilcinskas, A.
10.1101/2025.06.03.657594 — systems biology — Posted on 2025-06-06
3446 Benchmarking Docking Tools on Experimental and Artificial Intelligence-Predicted Protein Structures
Tejera Nevado, P.; Junod, N.; Hyunjin Kwon, E.; Prieto Santamaria, L.; Rodriguez Gonzalez, A.
10.1101/2025.06.03.657620 — bioinformatics — Posted on 2025-06-06
3447 Targeted Computational Design of an Interleukin-7 Superkine with Enhanced Folding Efficiency and Immunotherapeutic Efficacy
Lim, S.-K.; Lin, W.-C.; Pan, Y.-C.; Huang, S.-W.; Yu, Y.-A.; Chang, C.-H.; Hu, C.-M. J.; Mou, C.-Y.; Mou, K. Y.
10.1101/2025.06.03.657627 — bioengineering — Posted on 2025-06-06
3449 Structure of the central Staphylococcus aureus AAA+ protease MecA/ClpC/ClpP
Azinas, S.; Wallden, K.; Katikaridis, P.; Jenne, T.; Schahl, A.; Mogk, A.; Carroni, M.
10.1101/2025.06.06.658286 — biochemistry — Posted on 2025-06-06
3451 Parallelization of single-molecule binding kinetic measurements via protein barcode sequencing
Hutchinson, S.; Mansour, G. H.; Rehan, A.; Pichard-Kostuch, A.; Redheuil, E.; Reed, B. D.; Griffiths, A. D.; Ribezzi-Crivellari, M.
10.1101/2025.06.05.658126 — biochemistry — Posted on 2025-06-06
3452 Single-stranded DNA binding proteins are essential components of the architectural LDB1 protein complex
Wang, X.; Aboreden, N. G.; Cai, Y.; Lam, J. C.; Henderson, K. A.; Xiang, J.; Giardine, B. M.; Hardison, R. C.; Keller, C. A.; Nagarajan, L.; Brandt, S. J.; Blobel, G. A.
10.1101/2025.06.05.658047 — genomics — Posted on 2025-06-06
3453 Integrating multi-covariate disentanglement with counterfactual analysis on synthetic data enables cell type discovery and counterfactual predictions.
Megas, S.; Amani, A.; Rose, A.; Dufva, O.; Shamsaie, K.; Asadollahzadeh, H.; Polanski, K.; Haniffa, M.; Teichmann, S. A.; Lotfollahi, M.
10.1101/2025.06.03.657578 — genomics — Posted on 2025-06-06
3454 Non-invasive measures of DNA methylation capture molecular aging in wild capuchin monkeys
Sadoughi, B.; Hernandez-Rojas, R.; Hamou, H.; Lopez, R.; Mah, M.; Slikas, E.; Simmons, S. M.; Orkin, J. D.; Higham, J. P.; Brosnan, S. F.; Jack, K. M.; Campos, F. A.; Snyder-Mackler, N.; Melin, A. D.
10.1101/2025.06.03.657357 — genomics — Posted on 2025-06-06
3455 The CYP71A, NIT, AMI, and IAMH gene families are dispensable for indole-3-acetaldoxime-mediated auxin biosynthesis in Arabidopsis
Fenech, M.; Brumos, J.; Pencik, A.; Edwards, B.; Belcapo, S.; DeLacey, J.; Patel, A.; Kater, M. M.; Li, X.; Ljung, K.; Novak, O.; Alonso, J. M.; Stepanova, A. N.
10.1101/2025.06.03.657619 — genetics — Posted on 2025-06-06
3458 Negative epistasis limits current codon optimization approaches
Geees, M.; Raguz Nakic, Z.; Anisimova, M.; Garcia, V.; Peters, C.
10.1101/2025.06.03.657573 — molecular biology — Posted on 2025-06-06
3459 Dietary fibre promotes chronic whipworm infection through direct and time-dependent modulation of innate immunity
Myhill, L. J.; Jensen, P.; Arora, P.; Jensen, A. M.; Zhu, L.; Vedsted-Jakobsen, A.; Thormar, E. A.; von Munchow, A.; Poojary, M. M.; Lund, M. N.; Thamsborg, S. M.; Limborg, M. T.; Jensen, B. A. H.; Williams, A. R.
10.1101/2025.06.06.658267 — microbiology — Posted on 2025-06-06
3460 Post-sampling degradation of viral RNA in wastewater impacts the quality of PCR-based concentration estimates
Munday, J. D.; de Korne-Elenbaas, J.; Gan, C.; Lison, A.; Riou, J.; Ort, C.; Julian, T. R.; Stadler, T.
10.1101/2025.06.06.658243 — microbiology — Posted on 2025-06-06
3461 3'UTR-derived small RNA couples acid resistance to metabolic reprogramming of Salmonella within macrophages
Kanda, T.; Liu, F.; Kooshapour, H.; Reichardt, S.; Wang, M.; Icyishaka, P.; Obana, N.; Westermann, A. J.; Chao, Y.; Miyakoshi, M.
10.1101/2025.06.06.658255 — microbiology — Posted on 2025-06-06
3463 AlphaFold models of host-pathogen interactions elucidate the prevalence and structural modes of molecular mimicry
Baptista, D.; Gomez-Lucas, L.; Jänes, J.; Krogan, N. J.; Joao Amorim, M.; Ivarsson, Y.; Beltrao, P.
10.1101/2025.06.04.657796 — bioinformatics — Posted on 2025-06-06
3471 The HIV-1 envelope cytoplasmic tail protects infected cells from ADCC by downregulating CD4
Tauzin, A.; Belanger, E.; Prevost, J.; Medjahed, H.; Bourassa, C.; Bibollet-Ruche, F.; Richard, J.; Hahn, B. H.; Finzi, A.
10.1101/2025.06.06.658250 — microbiology — Posted on 2025-06-06
3472 Unraveling the prevalence and multifaceted roles of accessory peptide deformylases in bacterial adaptation and resistance
Lamberioux, M.; Ducos-Galand, M.; Kaminski, P.-A.; Littner, E.; Betton, J.-M.; Mechaly, A.; Haouz, A.; Mazel, D.
10.1101/2025.06.06.657839 — microbiology — Posted on 2025-06-06
3474 Influenza A virus polymerase co-opts distinct sets of host proteins for RNA transcription or replication
Rasmussen, A. B.; Swann, O. C.; Sukhova, K.; Liu, N.; Brown, M. D.; Martin-Sancho, L.; Sheppard, C. M.; Barclay, W. S.
10.1101/2025.06.06.658254 — microbiology — Posted on 2025-06-06
3477 Bacterial peptide deformylase inhibitors induce prophages in competitors
Chen, J.; Pfeifer, K.; Steensen, K.; Crooke, A. M.; Wolfram, M.; Bobonis, J.; Lopatina, A.; Bartlau, N.; Hussain, F. A.; Balskus, E. P.; Polz, M. F.; Blainey, P. C.
10.1101/2025.06.06.656871 — microbiology — Posted on 2025-06-06
3478 Uncovering differences in rye and wheat degradation by human gut microbiota applying a quantitative multi-metaOmics in vitro approach
Hartung, C. B.; Kelder, A.; Woltemate, S.; Geffers, R.; von Felde, A.; Bach Knudsen, K. E.; Visscher, C.; Vital, M.
10.1101/2025.06.06.658233 — microbiology — Posted on 2025-06-06
3479 A Combined Chemo-Enzymatic Treatment for the Oxidation of Epoxy-Based Carbon Fiber-Reinforced Polymers (CFRPs)
Wongwattanarat, S.; Schorn, A.; Klose, L.; Carre, C.; Malvis Romero, A.; Liese, A.; Perez-Garcia, P.; Streit, W. R.
10.1101/2025.06.04.657587 — biochemistry — Posted on 2025-06-06
3480 Comparative genomics-driven design of virus-delivered short RNA inserts triggering robust gene silencing
Garcia, A.; Aragones, V.; Gioiosa, S.; Herraiz, F. J.; Ortiz-Garcia, P.; Prohens, J.; Daros, J.-A.; Pasin, F.
10.1101/2025.06.03.657697 — plant biology — Posted on 2025-06-06
3481 Gene-embedding-based prediction and functional evaluation of perturbation expression responses with PRESAGE
Littman, R.; Levine, J.; Maleki, S.; Lee, Y.; Ermakov, V.; Qiu, L.; Wu, A.; Huang, K.; Lopez, R.; Scalia, G.; Biancalani, T.; Richmond, D.; Regev, A.; Hütter, J.-C.
10.1101/2025.06.03.657653 — bioinformatics — Posted on 2025-06-06
3484 Three novel genomes broaden the wild side of the Capsicum pangenome
Papastolopoulou, C.; Nieuwenhuis, R.; Warris, S.; Bakker, L. V.; van Haarst, J.; Cordewener, J.; Hesselink, T.; van den Broeck, H. C.; van Dooijeweert, W.; de Jong, H.; Chunwongse, J.; Diaz Trivino, S.; Schijlen, E.; de Ridder, D.; Smit, S.; Peters, S.
10.1101/2025.06.03.657591 — genomics — Posted on 2025-06-06
3485 Improved genome assembly of double haploid Prunus persica siblings Lovell 2D and Lovell 5D and the peach NLRome
Gottschalk, C.; Brock, j. R.; Mansfeld, B. N.; Main, D.; Jung, S.; Zheng, P.; Vann, C.; Demuth, M.; Bennett, D.; Liu, Z.; Dardick, C.
10.1101/2025.06.03.657495 — genomics — Posted on 2025-06-06
3486 Drivers of genetic diversity across the marine tree of life
Toczydlowski, R. H.; Brennan, R. S.; Crandall, E. D.; Kelley, J. L.; Pringle, J. M.; Riginos, C.; Wares, J. P.; Bradburd, G. S.
10.1101/2025.06.03.657718 — evolutionary biology — Posted on 2025-06-06
3488 Selective breeding enhances coral heat tolerance even over small spatial scales
Kler-Lago, A.; Kiefer, K.; Strader, M.; Baptista Nobre, T.; Hendricks, S.; Richter, C.; Wild, C.; Quigley, K.
10.1101/2025.06.04.657771 — ecology — Posted on 2025-06-06
3489 An optimized rabies vaccine vehicle for orotopical administration to wild vampire bats.
Knuese, C.; Cardenas-Canales, E. M.; McDevitt-Galles, T.; Ramirez-Martinez, M. M.; Limonta, D.; Powers, L. E.; Walsh, D. P.; Streicker, D. G.; Osorio, J. E.; Zamanian, M.; Rocke, T. E.
10.1101/2025.06.03.657068 — ecology — Posted on 2025-06-06
3491 Spatially organized inflammatory myeloid-CD8+ T cell aggregates linked to Merkel-cell Polyomavirus driven Reorganization of the Tumor Microenvironment
Haist, M.; Matusiak, M.; Tan, Y.; Zimmer, S.; Stege, H.; Kempchen, T. N.; Mitschke, S.; Chu, P.; Weidenthaler-Barth, B.; Barlow, G. L.; Rogall, F.; Delgado Gonzalez, A.; Baertsch, M. A.; Albertini, S.; Gariglio, M.; Borgogna, C.; Goltsev, Y.; Grabbe, S.; Hickey, J. W.; Nolan, G. P.
10.1101/2025.06.06.657162 — immunology — Posted on 2025-06-06
3492 Enhancing protective efficacy and immunogenicity of hemagglutinin-based influenza vaccine utilizing adjuvants developed by BECC
Das, S.; Tenaglia, B. M.; Riley, D.; Speed, S.; Baracco, L.; Gardner, F. M.; Varisco, D. J.; Yang, H.; Nijhuis, H.; Kerstetter, L.; Krammer, F.; Sun, W.; Frieman, M. B.; Ernst, R. K.
10.1101/2025.06.03.657703 — immunology — Posted on 2025-06-06
3493 Gene therapies alleviate absence epilepsy associated with Scn2a deficiency in DBA/2J mice
Zhang, Z.; Zhang, J.; Chen, X.; Deming, B. A.; Kant, S.; Mandal, P.; Kothandaraman, H.; SanMiguel, P. J.; Halurkar, M. S.; Abeyaratna, A. D.; Robinson, M. J.; Zhao, Y.; Vitko, Y.; Gaykema, R. P.; Yuan, C.; Lanman, N. A.; Tegtmeyer, M. T.; Wang, D.; Gao, G.; Shi, R.; Perez-Reyes, E.; Yang, Y.
10.1101/2025.06.03.657652 — neuroscience — Posted on 2025-06-06
3494 Intermingled representation of oral cavity in mouse trigeminal ganglion
Matunis, A.; Iwamoto, R.; Stacy, E.; Abe, K.; Tamura, S.; Kambe, Y.; Itokazu, T.; Hikida, T.; Sato, T.; Sato, T.
10.1101/2025.06.03.657656 — neuroscience — Posted on 2025-06-06
3495 Implantable CMOS Deep-Brain Fluorescence Imager with Single-Neuron Resolution
Yilmaz, S.; Choi, J.; Uguz, I.; Kim, J.; Akrouh, A.; Taal, A. J.; Andino-Pavlovsky, V.; Yin, H.; Fabbri, J. D.; Moreaux, L.; Roukes, M. L.; Shepard, K. L.
10.1101/2025.06.03.657675 — neuroscience — Posted on 2025-06-06
3497 PP2A METHYLESTERASE, PME-1, AND PP2A METHYLTRANSFERASE, LCMT-1, CONTROL SENSITIVITY TO IMPAIRMENTS CAUSED BY INJURY-RELATED OLIGOMERIC TAU
Sundaresh, S. N.; Vogel, E. W.; Hue, C. D.; Zhang, H.; Staniszewski, A.; Berman, H. L.; Gill, Z.; Asam, K.; Liang, S.; Shen, L.; Gnanaprakash, M.; Acquarone, E.; Fa, M.; Kanaan, N. M.; Morrison, B.; Arancio, O.; Nicholls, R. E.
10.1101/2025.06.05.657660 — neuroscience — Posted on 2025-06-06
3501 Genome-Wide Discovery and Characterization of Terpene Synthases Contributing to Strawberry Aroma Metabolism
Madera, M. M.; Becker, K. L.; Weissman, J. D.; Famula, R. A.; Bjornson, M.; Cole, G. S.; Feldmann, M. J.; Knapp, S. J.; Zerbe, P.
10.1101/2025.06.03.654341 — plant biology — Posted on 2025-06-06
3502 Microneedle-based precision payload delivery in plants
Li, M.; Poonam, A. D.; Singh, D.; Whitfield, A. E.; Wei, Q.
10.1101/2025.06.04.657704 — plant biology — Posted on 2025-06-06
3503 Double knockout of rice OsVIT1 and OsVIT2 genes reveals a trade-off between iron biofortification and iron excess tolerance
Benato, B. D.; Rativa, A. G. S.; Olsson, R. V.; Lima-Melo, Y.; Santos, E.; Montanha, G. S.; Alves, J. d. S.; Ponte, L. R.; Fiorentini, V. H. R.; Betin, F. M. M.; Ortolan, F.; Marques, J. P. R.; Sperotto, R. A.; Pereira de Carvalho, H. W. W. P.; Cesco, S.; Mimmo, T.; Tiziani, R.; Beone, G. M.; Navarro, N.; Roschzttardtz, H.; Perez, C. A.; Giehl, R. F. H.; Margis-Pinheiro, M.; Maraschin, F. d. S.; Ricachenevsky, F. K.
10.1101/2025.06.04.657710 — plant biology — Posted on 2025-06-06
3506 Lactate cannot replace glucose for maintaining the viability of mouse and human glioma cells
Miller, E. Y.; Duraj, T.; Ta, N. L.; Lee, D. C.; Mukherjee, P.; Shaver, O.; Seyfried, T. N.
10.1101/2025.06.03.655413 — cancer biology — Posted on 2025-06-06
3508 TORCphysics: A physical model of DNA-topology-controlled gene expression
Velasco Berrelleza, V. M.; Faulkner Rainford, P.; Mogre, A.; Benham, C. J.; Dorman, C. J.; Kroger, C.; Stepney, S.; Harris, S. A.
10.1101/2025.06.04.656888 — biophysics — Posted on 2025-06-06
3512 A Self-Supervised Foundation Model for Robust and Generalizable Representation Learning in STED Microscopy
Bilodeau, A.; Beaupre, F.; Chabbert, J.; Bellavance, J.-M.; Lessard, K.; Deschenes, A.; Bernatchez, R.; De Koninck, P.; Gagne, C.; Lavoie-Cardinal, F.
10.1101/2025.06.06.656993 — bioinformatics — Posted on 2025-06-06
3514 Ultrasensitive quantitative protein detection using Eu-ion doped vanadate nanoparticles
Kuhner, R.; Cardone, C.; Perrella, R.; Mousseau, F.; Mohammedi, R.; Sintes, J.-M.; Bourgeois, C.; Lambotte, O.; Gacoin, T.; Bouzigues, C. I.; Alexandrou, A.
10.1101/2025.06.03.657629 — bioengineering — Posted on 2025-06-06
3518 A progressive ratio task with costly resets reveals adaptive effort-delay tradeoffs
Rivera, Z. M. G.; Guerrero Leon, K.; Cervera, M.; Aguayo, B.; Izquierdo, A.; Wikenheiser, A. M.
10.1101/2025.06.03.657635 — animal behavior and cognition — Posted on 2025-06-06
3521 Vascular smooth muscle cell atherosclerosis trajectories characterized at single cell resolution identify causal transcriptomic and epigenomic mechanisms of disease risk
Li, D. Y.; Kundu, S.; Cheng, P.; Gu, W.; Jackson, W. R.; Zhao, Q.; Nguyen, T.; Worssam, M.; Monteiro, J. P.; Caceres, R. D.; Dale, S.; Palmisano, B.; Weldy, C. S.; Kundu, R.; Wirka, R. C.; Quertermous, T.
10.1101/2025.06.04.655863 — genomics — Posted on 2025-06-06
3524 Phylogenetically-informed crayfish conservation in the face of climate change
Pipins, S.; Bohm, M.; Bland, L.; Crandall, K. A.; Hossain, M. A.; Rosindell, J.; Gumbs, R.
10.1101/2025.06.03.657651 — ecology — Posted on 2025-06-06
3529 The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome
Shemtov, S. J.; McGann, E.; Carrillo, L.; Lee, S.; Anson, H.; Chung, C. S.; Anagnostou, M.-E.; Lai, G.-J. D.; Verheijen, B. M.; Wan, J.; Vorobyova, I.; Sanchez-Contreras, M.; Conover, C. A.; Thorwald, M. A.; Cohen, P.; Kennedy, S. R.; Gout, J.-F.; Haroon, S.; Vermulst, M.
10.1101/2025.06.03.656903 — molecular biology — Posted on 2025-06-06
3531 Metabolic controls on the carbon isotope fractionations of bacterial fermentation
Mueller, E.; Heuer, V. B.; Leadbetter, J. R.; Hinrichs, K.-U.; Sessions, A. L.
10.1101/2025.06.06.655161 — microbiology — Posted on 2025-06-06
3534 Pangenome-aware DeepVariant
Asri, M.; Chang, P.-C.; Mier, J. C.; Siren, J.; Eskandar, P.; Kolesnikov, A.; Cook, D. E.; Brambrink, L.; Hickey, G.; Novak, A. M.; Dorfman, L.; Webster, D. R.; Carroll, A.; Paten, B.; Shafin, K.
10.1101/2025.06.05.657102 — bioinformatics — Posted on 2025-06-06
3535 Whole chloroplast genomes reveal a complex genetic legacy of lost lineages, past radiations and secondary contacts in the dominant temperate deciduous tree genus Fagus
Worth, J. R. P.; Grimm, G. W.; Ihara-Udino, T.; Li, P.; Papageorgiou, A. C.; Simeone, M. C.; Shanjani, P. S.; Lopez-Saez, J. A.; Chiang, Y.-C.; Kitamura, K.; Tomaru, N.; Denk, T.
10.1101/2025.06.03.653586 — evolutionary biology — Posted on 2025-06-06
3536 Early neuronal reprogramming and cell cycle reentry shape Alzheimer's disease progression
Meir, R.; Schwartz, G.; Adam, M.; Avni Lapidot, A.; Cain, A.; Green, G. S.; Menon, V.; Bennett, D. A.; De Jager, P.; Habib, N.
10.1101/2025.06.04.653670 — neuroscience — Posted on 2025-06-06
3539 Spatial and single-cell transcriptomics capture two distinct cell states in plant immunity
Hu, Y.; Schaefer, R.; Rendleman, M.; Slattery, A.; Cramer, A.; Nahiyan, A.; Breitweiser, L.; Shah, M.; Kaehler, E.; Yao, C.; Bowling, A.; Crow, J.; May, G.; Tabor, G.; Thatcher, S.; Uppalapati, S. R.; Muppirala, U.; Deschamps, S.
10.1101/2025.06.03.657683 — plant biology — Posted on 2025-06-06
3542 Cooperation between a root fungal endophyte and host-derived coumarin scopoletin mediates Arabidopsis iron nutrition
Van Dijck, L.; Esposto, D.; Huelsmann, C.; Malisic, M.; Piro, A.; Giehl, R. F. H.; Balcke, G. U.; Tissier, A.; Parker, J. E.
10.1101/2025.06.04.657782 — plant biology — Posted on 2025-06-06
3543 Redesigning petal shape, size, and color in soybean reveals unexpected phenotypes for floral organ development
Szeluga, N.; AlBader, N.; Pelletier, S.; Weis, K.; Johnson, A.; Fahlgren, N.; Neequaye, M.; Vogt, G.; DelPercio, R.; Baldrich, P.; Byers, K. J. R. P.; Meyers, B. C.; Frank, M.
10.1101/2025.06.05.657847 — plant biology — Posted on 2025-06-06
3544 Accurately Programming Complex Light Regimes with Multi-channel LEDs
Vong, G. Y. W.; Scott, P.; Claydon, W.; Daff, J.; Denby, K.; Ezer, D.
10.1101/2025.06.06.658293 — plant biology — Posted on 2025-06-06
3545 FLOE1 maintains cellular viscosity in rehydrating Arabidopsis embryos
Field, S.; Ramirez, J. F.; Dorone, Y.; Cox, J. A.; Boothby, T. C.; Rhee, S. Y.
10.1101/2025.06.03.657678 — plant biology — Posted on 2025-06-06
3546 Unraveling the cis-regulatory code controlling abscisic acid-dependent gene expression in Arabidopsis using deep learning
Opdebeeck, H.; Smet, D.; Thierens, S.; Minne, M.; De Beukelaer, H.; Zuallaert, J.; Van Bel, M.; Van Montagu, M.; Degroeve, S.; De Rybel, B.; Vandepoele, K.
10.1101/2025.06.03.657584 — plant biology — Posted on 2025-06-06
3551 Statin-dye conjugates for selective targeting of KRAS mutant cancer cells
Moon, H.-r.; Cai, Z.; Cho, B. K.; Chang, H.; Hong, S. T.; Zhao, J. J.; Kwon, I. C.; Roberts, T. M.; Han, B.; Ryu, J. H.
10.1101/2025.06.03.657329 — cancer biology — Posted on 2025-06-06
3555 Postnatal Pulmonary Artery Development from Transcript to Tissue
Schwarz, E. L.; Ramachandra, A. B.; Yeung, N.; Manning, E. P.; Weiss, D.; Humphrey, J. D.
10.1101/2025.06.03.657639 — bioengineering — Posted on 2025-06-06
3559 Antigen-specific Th17 T cells offset the age-related decline in durable T cell immunity
Sturmlechner, I.; Jain, A.; Jiang, J.; Okuyama, H.; Mu, Y.; Own, M.; Weyand, C.; Goronzy, J.
10.1101/2025.06.05.658069 — immunology — Posted on 2025-06-06
3560 Spatial transcriptomic analysis of muscle biopsy from treatment-naive juvenile dermatomyositis patients reveals mitochondrial abnormalities despite disease-related interferon driven signature
Syntakas, A. E.; Kartawinata, M.; Evans, N. M. L.; Nguyen, H. D.; Papadopoulou, C.; Al Obaidi, M.; Pilkington, C.; Glackin, Y.; Mahony, C. B.; Croft, A. P.; Eaton, S.; Cortina-Borja, M.; Ogunbiyi, O.; Merve, A.; Wedderburn, L. R.; Wilkinson, M. G. L.; UK JDM Cohort and Biomarker Study (JDCBS),
10.1101/2025.06.03.657601 — immunology — Posted on 2025-06-06
3561 Synthetic Serum Markers Enable Noninvasive Monitoring of Gene Expression in Primate Brains
Lee, S.; Romac, M.; Watanabe, S.; Chernov, M.; Li, H.; Raisley, E.; Szablowski, J. O.; Costa, V. D.
10.1101/2025.06.01.657212 — neuroscience — Posted on 2025-06-06
3562 A discontinuity in motion perception during fixational drift
D'Angelo, J. C.; Tiruveedhula, P.; Weber, R. J.; Arathorn, D. W.; Otero-Millan, J.; Roorda, A.
10.1101/2025.06.02.657265 — neuroscience — Posted on 2025-06-06
3564 GPX4 Promotes Optic Nerve Regeneration and RGC Neuroprotection
Yang, M.; Bian, F.; Feng, X.; Li, L.; Huang, H.; Liu, L.; Dalal, R.; Yang, H.; Suraparaju, P. V.; Cao, F.; Ong, P.; Luo, A.; Liu, D.; Hu, Y.
10.1101/2025.06.03.657677 — neuroscience — Posted on 2025-06-06
3567 Heterogeneity in human brain clearance adds resilience against tauopathy -- a computational model informed by glymphatic MRI
Brennan, G. S.; Thompson, T. B.; Oliveri, H.; Vinje, V.; Ringstad, G.; Eide, P. K.; Goriely, A.; Rognes, M. E.
10.1101/2025.06.03.657596 — neuroscience — Posted on 2025-06-06
3571 Extracting Reproducible Components from Electroencephalographic Responses to Transcranial Magnetic Stimulation with Group Task-Related Component Analysis
Couto, B. A. N.; Fecchio, M. N.; Russo, S.; De Martino, E.; Parmigiani, S.; Sarasso, S.; Graven-Nielsen, T.; de Andrade, D. C.; Massimini, M.; Rosanova, M.; Casali, A. G.
10.1101/2025.06.02.657489 — neuroscience — Posted on 2025-06-06
3574 The Neurofibrillary Tangle Maturity Scale: A Novel Framework for Tangle Pathology Evaluation in Alzheimer's Disease
Moloney, C. M.; Rutledge, M. H.; Labuzan, S. A.; Peng, Z.; Tranovich, J. F.; Wood, A. C.; Rothberg, D. M.; Duara, R.; Lachner, C.; Graff-Radford, N. R.; Dickson, D. W.; Kanaan, N. M.; Carter, R. E.; Murray, M. E.
10.1101/2025.06.02.657435 — neuroscience — Posted on 2025-06-06
3579 Uncovering the invisible giant: Amyloid β plaques and their proposed association with waste removal in Alzheimer-affected human hippocampus
Fabian-Fine, R.; Roman, A. G.; Winters, M. J.; Lathram, K. J.; Bennett, C. H.; Kipingi, L. K.; Braennare-Gran, S. M.; Whitley, A. E.; Paul, C. M.; Altman, L. M.; Carrillo, I. C.; Joyce, F. M.; Kragh, L. A.; McKnight, T. J.; Reding, C. J.; Reiderer, L. J.; Rivera, L. J.; Steen, H. A.; Weaver, A. L.
10.1101/2025.06.01.657219 — neuroscience — Posted on 2025-06-06
3581 An improved model for prediction of de novo designed proteins with diverse geometries
Orr, B.; Crilly, S. E.; Akpinaroglu, D.; Zhu, E.; Keiser, M. J.; Kortemme, T.
10.1101/2025.06.02.657515 — bioinformatics — Posted on 2025-06-06
3583 Comparative population genomics of relictual Caribbean island Gossypium hirsutum
Ning, W.; Hu, G.; Yuan, D.; Arick, M. A.; Hsu, C.-Y.; Magbanua, Z. V.; Pechanova, O.; Peterson, D. G.; Dong, Y.; Udall, J.; Grover, C.; Wendel, J.
10.1101/2025.06.02.657498 — evolutionary biology — Posted on 2025-06-06
3584 Habitat use of juvenile green turtles along the North Pacific coast of Costa Rica
Wu, F.; Valverde-Cantillo, V.; Durr, C.; Espinoza, M.; Lowe, C.; Heidemeyer, m.; Spotila, J. R.; Paladino, F.
10.1101/2025.06.02.657549 — ecology — Posted on 2025-06-06
3586 The Impact of Coronary Artery Disease on Brain Vascular and Metabolic Health: Links to Cognitive Function
Sanami, S.; Tremblay, S. A.; Rezaei, A.; Potvin-Jutras, Z.; Sabra, D.; Intzandt, B.; Gagnon, C.; Mainville-Berthiaume, A.; Wright, L.; Gayda, M.; Iglesies-Grau, J.; Nigam, A.; Bherer, L.; Gauthier, C.
10.1101/2025.06.02.657532 — biophysics — Posted on 2025-06-06
3589 Personalized mapping of inhibitory spinal cord circuits in vivo via non-invasive neural decoding and in silico modelling
Pascual-Valdunciel, A.; Consul, N.; Brownstone, R. M.; Beato, M.; Farina, D.; Nascimento, F.; Ozyurt, M. G.
10.1101/2025.03.25.645235 — neuroscience — Posted on 2025-06-06
3594 OrganoidChip+: a Microfluidic Platform for Culturing, Staining, Immobilization, and High-Content Imaging of Adult Stem Cell-Derived Organoids
Moshksayan, K.; Khanna, R.; Camli, B.; Yakay, Z. N.; Harihara, A.; Zdyrski, C.; Mondal, S.; Hegarty, E.; Mochel, J. P.; Allenspach, K.; Ben-Yakar, A.
10.1101/2025.06.02.657499 — bioengineering — Posted on 2025-06-06
3596 Developmental dynamic transcriptomics reveals multiple effectors and transcription factors critical for Ditylenchus destructor parasitism
Dai, D.; Chen, Y.; Zhang, S.; Zhou, Y.; Wang, X.; Bo, D.; Liao, Y.; Hu, B.; Zhang, Y.; Ashry, N. M.; Peng, D.; Sun, M.
10.1101/2025.06.02.657539 — genomics — Posted on 2025-06-06
3597 Carotenoid-based immune response in sea cucumbers relies on newly identified coelomocytes -- the carotenocytes
Wambreuse, N.; Bossiroy, E.; David, F.; Vanwinge, C.; Fievez, L.; Bureau, F.; Gabriele, S.; Karasiewicz, T.; Mascolo, C.; Wattiez, R.; Eeckhaut, I.; Caulier, G.; Delroisse, J.
10.1101/2025.06.02.657395 — evolutionary biology — Posted on 2025-06-06
3598 A comparison shopper's guide to forest datasets
Lee, L. G.; Pasquarella, V. J.; Glass, B.; Morreale, L. L.; Chung, N.; Gao, X.; Thompson, J.
10.1101/2025.06.02.657445 — ecology — Posted on 2025-06-06
3601 Branched actin networks in innate immune cells mediate host microbiota homeostasis.
Vasconcellos, L. R.; Huang, S. C. M.; Suarez-Bonnet, A.; Priestnall, S.; Chakravarty, P.; Varsani-Brown, S.; Winder, M. L.; Shah, K.; Kogata, N.; Stockinger, B.; Way, M.
10.1101/2024.07.18.604111 — immunology — Posted on 2025-06-06
3602 Retinal tau phosphorylation in Alzheimer's disease: a mass spectrometry study
Santiago, J.; Poceviciute, D.; Vogel, J.; The Netherlands Brain Bank, ; Brinkmalm, G.; Wennstrom, M.
10.1101/2025.02.17.638688 — neuroscience — Posted on 2025-06-06
3603 Metabolic reprogramming and altered ATP content impair neuroprotective functions of microglia in β-glucocerebrosidase deficiency models
Brunialti, E.; Villa, A.; Szego, E. M.; La Vitola, P.; Drago, D.; Pavlovic, R.; Fontana, L.; Tuna, D.; Panzeri, A.; Meda, C.; Rondinone, O.; Pitasi, M.; Miozzo, M.; Andolfo, A.; Di Monte, D. A.; Ciana, P.
10.1101/2025.05.26.656111 — neuroscience — Posted on 2025-06-06
3605 CAN TRANSFER LEARNING IMPROVE SUPERVISED SEGMENTATIONOF WHITE MATTER BUNDLES IN GLIOMA PATIENTS?
Riccardi, C.; Ghezzi, S.; Amorosino, G.; Zigiotto, L.; Sarubbo, S.; Jovicich, J.; Avesani, P.
10.1101/2023.07.31.551318 — neuroscience — Posted on 2025-06-06
3607 BEHAV3D Tumor Profiler to map heterogeneous cancer cell behavior in the tumor microenvironment
Rios-Jimenez, E.; Zomer, A.; Collot, R.; Barrera Roman, M.; Ariese, H.; L. van Ineveld, R.; Kleinnijenhuis, M.; Bessler, N.; Johnson, H.; Dawson, C.; Rios, A.; Alieva, M.
10.1101/2024.08.23.609358 — cancer biology — Posted on 2025-06-06
3609 OriGene: A Self-Evolving Virtual Disease Biologist Automating Therapeutic Target Discovery
Zhang, Z.; Qiu, Z.; Wu, Y.; Li, S.; Wang, D.; Zhou, Z.; An, D.; Chen, Y.; Li, Y.; Wang, Y.; Ou, C.; Wang, Z.; Chen, J. X.; Zhang, B.; Hu, Y.; Zhang, W.; Wei, Z.; Ma, R.; Liu, Q.; Dong, B.; He, Y.; Feng, Q.; Bai, L.; Gao, Q.; Sun, S.; Zheng, S.
10.1101/2025.06.03.657658 — bioinformatics — Posted on 2025-06-06
3611 Development of a PEGylated Parylene Nanopocket Membrane for the Capture and Release of Lipid Vesicles
Alsudais, M.; Petersen, K.; Hosseinifakhr, A.; Frasch, L.; Gholizadeh, S.; Dehghani, M.; Gaborski, T. R.
10.1101/2025.06.02.657433 — bioengineering — Posted on 2025-06-06
3615 Possible exposure to unidentified coronaviruses in roe deer (Capreolus capreolus) populations suggested by SARS-CoV-2 serological investigation in France
Perez, G.; Lalande, L. D.; Legros, V.; Kodjo, A.; Verheyden, H.; Bourret, V.; Cebe, N.; Chaval, Y.; Revelli, P.; Pellerin, M.; Lemaitre, J.-F.; Peroz, C.; Rey, B.; Debias, F.; Garcia, R.; Bourgoin, G.; Gilot-Fromont, E.
10.1101/2025.02.19.639030 — immunology — Posted on 2025-06-06
3616 c-Myc inhibits macrophage antimycobacterial response in Mycobacterium tuberculosis infection
Sarti, E.; Dolle, C.; Wolfensberger, R.; Kusejko, K.; Russenberger, D.; Bredl, S.; Speck, R. F.; Greter, M.; Rueschoff, J. H.; Boeck, L.; Mai, D.; Diercks, A. H.; Sander, P.; Olson, G. S.; Nemeth, J.
10.1101/2025.01.09.632095 — immunology — Posted on 2025-06-06
3618 Endophytes induce systemic spatial reprogramming of metabolism in poplar roots under drought
Aufrecht, J. A.; Velickovic, D.; Tournay, R.; Couvillion, S. P.; Balasubramanian, V. K.; Winkler, T.; Herrera, D.; Stanley, R.; Doty, S.; Ahkami, A. H.
10.1101/2025.06.02.657501 — plant biology — Posted on 2025-06-06
3619 The architecture of resilience: a genome assembly of Myrothamnus flabellifolia sheds light on desiccation tolerance and sex determination
Marks, R.; Lovell, J. T.; Carey, S. B.; Van Der Pas, L.; Chimukuche, N. M.; Bruna, T.; Plott, C.; Webber, J.; Lipzen, A.; Yan, J.; Bauer, D.; Bentley, J.; Talag, J.; Barry, K.; Grimwood, J.; Jenkins, J. W.; Schmutz, J.; Harkess, A.; VanBuren, R.; Leebens-Mack, J.; Farrant, J. M.
10.1101/2025.06.02.657439 — plant biology — Posted on 2025-06-06
3620 New alleles of Arabidopsis BIK1 reinforce its predominant role in pattern-triggered immunity and caution interpretations of other reported functions
Song, B.; Choi, S.; Kong, L.; Kim, S.-I.; Fliegmann, J.; Li, X.; DeFalco, T. A.; Hu, M.; Li, M.; Zhao, Y.; Wang, H.; Shan, L.; Nuernberger, T.; He, P.; zipfel, c.; Zhou, J.-M.
10.1101/2025.06.02.657414 — plant biology — Posted on 2025-06-06
3624 A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics
Autorino, C.; Khoromskaia, D.; Harari, L.; Floris, E.; Booth, H.; Pallares-Cartes, C.; Petrasiunaite, V.; Dorrity, M.; Corominas-Murtra, B.; Hadjivasiliou, Z.; Petridou, N.
10.1101/2025.06.06.658228 — developmental biology — Posted on 2025-06-06
3625 In vivo nuclear envelope adaptation during cell migration across confining embryonic tissue environments
Haekkinen, H.-M.; Villaseca, S.; Alhashem, Z.; Chomiczewski, S.; Desevedavy, M.; Leleux, S.; Hamidzadeh, A.; Gallo, F.; El-Zohiry, D.; Petre, V. G.; Scarpa, E.
10.1101/2025.06.05.658077 — developmental biology — Posted on 2025-06-06
3626 Global profiling of the proteome and acetylome in mice with abdominal aortic aneurysms
Yang, J.; Zhang, L.; Yang, B.; Ding, T.; Zhao, Y.; Yang, Y.; Tang, X.; Wu, Y.; Wang, Q.; Zhang, Z.; Shi, C.; Han, R.; Zhang, X.; Liu, J.
10.1101/2025.06.02.657536 — bioinformatics — Posted on 2025-06-06
3631 Cardiac fibroblasts counterbalance cardiomyocytes in LMNA cardiomyopathy pathogenesis
Sikder, K.; Phillips, E.; Bouhrira, N.; Mothy, D.; Wang, N.; Bonne, G.; Margulies, K. B.; Choi, J. C.
10.1101/2025.06.05.657412 — cell biology — Posted on 2025-06-06
3632 Wolbachia induces host cell identity changes and determines symbiotic fate in Drosophila
Jacobs, J.; Mirchandani, C. D.; Seligmann, W. E.; Sacco, S.; Escalona, M.; Green, R. E.; Russell, S.
10.1101/2025.06.05.658111 — cell biology — Posted on 2025-06-06
3634 ezscore-f: A Set of Freely Available, Validated Sleep Stage Classifiers for Forehead EEG
Coon, W. G.; Zerr, P.; Milsap, G.; Sikder, N.; Smith, M.; Dresler, M.; Reid, M.
10.1101/2025.06.02.657451 — neuroscience — Posted on 2025-06-06
3637 Modelling medulloblastoma pathogenesis and treatment in human cerebellar organoids.
Willott, T. O.; Nicholson, J. G.; Xiao, Y.; Ogunbiyi, O. K.; Draper, B.; Mistry, T.; Donovan, L.; Zabet, N. R.; Merve, A.; Badodi, S.; Marino, S.
10.1101/2024.08.14.607977 — cancer biology — Posted on 2025-06-06
3639 A photostable genetically encoded voltage indicator for imaging neural activities in tissue and live animals
Cao, C.; Zhu, R.; Zhou, S.; Zhao, Z.; Lin, C.; Liu, S.; Peng, L.; Subach, F. V.; Piatkevich, K. D.; Zou, P.
10.1101/2025.05.29.656768 — bioengineering — Posted on 2025-06-06
3641 A high-quality reference genome for the Ural Owl (Strix uralensis) enables investigations of cell cultures as a genomic resource for endangered species
Chrysostomakis, I.; Mozer, A.; Bruno Di-Nizo, C.; Fischer, D.; Sargheini, N.; von der Mark, L.; Huettel, B.; Astrin, J. J.; Toepfer, T.; Boehne, A.
10.1101/2025.01.22.633903 — genomics — Posted on 2025-06-06
3642 Comprehensive molecular impact mapping of common and rare variants at GWAS loci
Balderson, B.; Tule, S.; Okino, M.-L.; Rieger, W. J.; Corban, S.; Jaureguy, J.; Palpant, N.; Gaulton, K. J.; Boden, M.; McVicker, G.
10.1101/2025.06.05.658079 — genetics — Posted on 2025-06-06
3643 Complex genetic determinism of male-fertility restoration in the gynodioecious snail Physa acuta
Skarlou, E.; Laugier, F.; Bethune, K.; Chenin, T.; Donnay, J.-M.; Froissard, C.; David, P.
10.1101/2024.08.08.607164 — evolutionary biology — Posted on 2025-06-06
3645 A distinct phase of cyclin B (Cdc13) nuclear export at mitotic entry in S. pombe
Chethan, S. G.; Rogers, J. M.; Vijayakumari, D.; Williams, W.; Gligorovski, V.; Rahi, S. J.; Hauf, S.
10.1101/2025.06.05.658100 — cell biology — Posted on 2025-06-06
3648 A single factor for safer cellular rejuvenation
de Lima Camillo, L. P.; Gam, R.; Maskalenka, K.; LeBlanc, F. J.; Urrutia, G. A.; Mejia, G. M.; Miller, H. E.; Wardlaw, C. P.; Pickles, A.; Everton, L.; Zaksauskaite, R.; Khan, R. B.; Welsh, A.; Gambo, S.; Gallardo, S.; Oliynyk, Z.; Varankar, S. S.; Epstein, A. E.; Bendall, A.; Mowatt, J.; Ives, D.; Swain, B. M.
10.1101/2025.06.05.657370 — cell biology — Posted on 2025-06-06
3651 Phage intervention improves colitis and response to corticosteroids by attenuating virulence of Crohn's disease-associated bacteria
Jackson, K.; Galipeau, H.; Hann, A.; Constante, M.; Zangara, M.; Bording-Jorgensen, M.; Fuentes, A.; Ho, H.; Wang, J.; Shimbori, C.; Moayyedi, P.; Surette, M. G.; Bercik, P.; Coombes, B.; Hosseinidoust, Z.; Verdu, E. F.
10.1101/2025.06.05.658057 — microbiology — Posted on 2025-06-06
3653 Unipolar polysaccharide-mediated attachment of the N2O-reducing bacterium Bradyrhizobium ottawaense SG09 to plant roots.
Takeguchi, Y.; Shibuya, R.; Kondo, M.; Betsuyaku, E.; Itakura, M.; Minamisawa, K.; Sugawara, M.; Betsuyaku, S.
10.1101/2025.06.05.658015 — microbiology — Posted on 2025-06-06
3656 Dendritic inhibition terminates plateau potentials in CA1 pyramidal neurons
Vaasjo, L. O.; Kotermanski, S. E.; Patel, T.; Shi, H. J.; Machold, R.; Chamberland, S.
10.1101/2025.06.05.657434 — neuroscience — Posted on 2025-06-06
3658 Two time scales of adaptation in human learning rates
Simoens, J.; Braem, S.; Verbeke, P.; Chen, H.; Mattioni, S.; Chai, M.; Schuck, N. W.; Verguts, T.
10.1101/2025.06.05.658048 — neuroscience — Posted on 2025-06-06
3662 Extracellular Vesicles from Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement, and Aging-related Pathway Dysregulation
Jank, L.; Satheesh Kumar, M. K.; Ryu, T.; Thapa, R.; Gololobova, O.; Niepokny, T.; Calabresi, P. A.; Witwer, K. W.; Dutta, R.; Na, C. H.; Bhargava, P.
10.1101/2025.06.02.657509 — neuroscience — Posted on 2025-06-06
3663 Heritable Large Deletions Using Type I-E CRISPR-Cas3 in Rice
Saika, H.; Hara, N.; Yasumoto, S.; Muranaka, T.; Yoshimi, K.; Mashimo, T.; Toki, S.
10.1101/2025.06.05.658196 — plant biology — Posted on 2025-06-06
3664 aNy-way ICA and its application to estimate cortico-thalamo-cerebellar functional links in schizophrenia
Duan, K.; Silva, R. F.; Rahaman, M. A.; Fu, Z.; Liu, J.; Kochunov, P.; van Erp, T. G. M.; Shultz, S.; Calhoun, V. D.
10.1101/2025.06.02.657541 — neuroscience — Posted on 2025-06-06
3665 Regulators of Interferon-Responsive Microglia Uncovered by Genome-wide CRISPRi Screening
McQuade, A.; Castillo, V. C.; Hagan, V.; Liang, W.; Ta, T.; Mishra, R.; Teter, O.; Teyssier, N.; Leng, K.; Kampmann, M.
10.1101/2025.06.05.658176 — neuroscience — Posted on 2025-06-06
3666 Neural coding of spectrotemporal modulations in the auditory cortex supports speech and music categorization
Ginzburg, J.; Debaque, E. C.; Borderie, A.; Morillon, B.; Martineau, L.; Bonaventure, P. L.; Albouy, P.; Zatorre, R.
10.1101/2025.06.05.657930 — neuroscience — Posted on 2025-06-06
3668 Increasing Stemness Drives Prostate Cancer Progression, Plasticity, Therapy Resistance and Poor Patient Survival
Liu, X.; Cortes, E.; Ji, Y.; Zhao, K.; Ho, J.; Liu, Y. S.; Davicioni, E.; Feng, F. Y.; Alumkal, J. J.; Spratt, D. E.; Sweeney, C. J.; Yu, H.; Hu, Q.; Cheng, Z.; Zhang, D.; Chatta, G.; Nastiuk, K. L.; Goodrich, D. W.; Rycaj, K.; Jamroze, A.; Kirk, J. S.; Puzanov, I.; Liu, S.; Wang, J.; Tang, D. G.
10.1101/2025.04.27.650697 — cancer biology — Posted on 2025-06-06
3672 Spontaneous cell morphogenesis via self-propelled actin filaments
Yagami, K.; Baba, K.; Minegishi, T.; Misu, S.; Katsuno-Kambe, H.; Okano, K.; Sakumura, Y.; Hosokawa, Y.; Inagaki, N.
10.1101/2024.02.28.582450 — cell biology — Posted on 2025-06-06
3673 Towards Unified Neural Decoding with Brain Functional Network Modeling
Wu, D.; Bu, L.; Jia, Y.; Cao, L.; Li, S.; Zhou, Y.; Fan, S.; Ren, W.; Wu, D.; Wang, K.; Zhang, Y.; Ma, Y.; Yang, J.; Sawan, M.
10.1101/2025.06.02.657011 — neuroscience — Posted on 2025-06-05
3675 Phosphoproteome modifications and cortical circuit dysfunction are linked to the early-stage progression of alpha-synuclein aggregation.
Dutta, S.; Hensel, J.; Scott, A.; Mohallem, R.; Rossitto, L.-A. M.; Khan, H. F.; Johnson, T.; Ferreira, C. R.; Diehl, L. A.; Marmolejo, J. F.; Chen, X.; Jayant, K.; Aryal, U. K.; Volpicelli-Daley, L.; Rochet, C.
10.1101/2025.01.24.634820 — neuroscience — Posted on 2025-06-06
3676 A continuous landscape of signaling encodes a corresponding landscape of CAR T cell phenotype
Cho, W.; Liu, J. Y.; Beckett, A. N.; Lunger, J. C.; Xu, P.; Ho, K.; Chen, E. E.; Salcido-Alcantar, A.; Sant'Anna, L. E.; Obbad, K.; Po, N.; Sotillo, E.; Mackall, C. L.; Daniels, K. G.
10.1101/2025.06.05.658149 — synthetic biology — Posted on 2025-06-05
3677 Non-Invasive Mechanical-Functional Analysis of Individual Liver Mitochondria by Atomic Force Microscopy
Zorikova, E. O.; Chourasia, S.; Rosenhek-Goldian, I.; Cohen, S. R.; Nesterov, S. V.; Gross, A.
10.1101/2025.06.01.657242 — biophysics — Posted on 2025-06-05
3679 De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors
Muratspahic, E.; Feldman, D.; Kim, D. E.; Qu, X.; Bratovianu, A.-M.; Rivera-Sanchez, P.; Dimitri, F.; Cao, J.; Cary, B. P.; Belousoff, M. J.; Keov, P.; Chen, Q.; Ren, Y.; Fine, J.; Sappington, I.; Schlichthaerle, T.; Zhang, J. Z.; Pillai, A.; Mihaljevic, L.; Bauer, M.; Torres, S. V.; Motmaen, A.; Lee, G. R.; Tran, L.; Wang, X.; Goreshnik, I.; Vafeados, D. K.; Svendsen, J. E.; Hosseinzadeh, P.; Lindegaard, N.; Brandt, M.; Waltenspühl, Y.; Deibler, K.; Oostdyk, L.; Cao, W.; Anantharaman, L.; Stewart, L.; Halloran, L.; Spangler, J. B.; Sexton, P. M.; Roth, B. L.; Krumm, B. E.; Wootten, D.; Tate,
10.1101/2025.03.23.644666 — bioengineering — Posted on 2025-06-05
3680 Deciphering the thiolactonization mechanism in thiolactomycin biosynthesis
Guo, J.; Zhang, Q.; Shen, Y.; Cheng, F.; Sang, M.; Wang, X.; Pan, Y.; Liu, M.; Yu, H.-B.; Hu, B.; Wang, S.; Zheng, L.; Geng, C.; Yang, C.; Luo, L.; Zhang, G.; Du, L.; Li, Y.; Zhang, W.; Zhang, Y.; Wang, B.; Li, S.; Zhang, X.
10.1101/2024.12.18.629141 — biochemistry — Posted on 2025-06-05
3682 Inhalable Perfluorocarbon Nanocapsules for RNA-based Immunotherapeutic Treatment of Lung Metastases
Siddhanta, K.; Monirvaghef, A.; Sundar, A.; Pinkerton, B. R.; Kumari, N.; Ding, L.; Woslager, C. J.; Kalpana, M. A.; Jogdeo, C. M.; Ravnholdt, A. R.; Poole, J. A.; Santarpia, J.; Talmadge, J. E.; Oupicky, D.
10.1101/2025.06.05.658088 — bioengineering — Posted on 2025-06-05
3683 Aromatic Patch in WhiB-Like Transcription Factors Facilitates Primary Sigma Factor Interaction in Mycobacterium tuberculosis
Beltran, D. G.; Wan, T.; Seravalli, J.; Horova, M.; Jones, C.; Li, S.; Ma, P.; Becker, D.; Mower, J. P.; Yao, Q.; Pan, Y.; Yu, H.; Steyn, A. J.; Zhang, L.
10.1101/2025.06.05.653497 — biochemistry — Posted on 2025-06-05
3684 Changes in biophysical characteristics of YghA from E. coli due to variation in pH
Hasan, N.; Jilani, S. B.; Saeed, S.; Stoner, M. R.; Yazdani, S. S.; Choi, Y.; Khan, R. H.
10.1101/2025.06.05.657471 — biochemistry — Posted on 2025-06-05
3689 RNA structure directs RNA partitioning and is actively disrupted inside stress granules to enable cellular recovery
Zhu, B.; Lim, J. J. A.; Zhang, Y.; Tan, W. T.; Zhang, J.; Xiang, J. S. N.; Huber, R.; Khong, A.; Wan, Y.
10.1101/2025.06.05.658090 — molecular biology — Posted on 2025-06-05
3695 A continuous landscape of signaling encodes a corresponding landscape of CAR T cell phenotype
Cho, W.; Liu, J. Y.; Beckett, A. N.; Lunger, J. C.; Xu, P.; Ho, K.; Chen, E. E.; Salcido-Alcantar, A.; Sant'Anna, L. E.; Obbad, K.; Po, N.; Sotillo, E.; Mackall, C. L.; Daniels, K. G.
10.1101/2025.06.05.658149 — synthetic biology — Posted on 2025-06-05
3699 The Immunophenotype and Proviral Landscape of HIV-infected CD4 T Cells During Antiretroviral Therapy
Delley, C. L.; Shah, S.; Joslin, K. M.; Park, Y. P.; Busch, M. P.; Stone, M.; Demaree, B.; Deeks, S. G.; Boritz, E. A.; Abate, A. R.; Clark, I. C.
10.1101/2025.06.05.657210 — genomics — Posted on 2025-06-05
3702 Evaluation of Enterobacterales carrying Acinetobacter-associated blaOXA genes--United States, 2017-2022
Orazi, G.; Kent, A. G.; Wilmott, N.; Berhe, D.; Longo, C.; Bumpus-White, P.; Rutledge, D.; Hovan, G.; Villegas Correa, I. M.; Otero Pagan, I.; Coe, P.; Therrien, M.; Bhatnagar, A.; McKay, S. L.; Brown, A. C.; Laufer Halpin, A.; Sabour, S.
10.1101/2025.06.05.655513 — microbiology — Posted on 2025-06-05
3704 Training-induced alterations in the modulation of human motoneuron discharge patterns with contraction force
Skarabot, J.; Thomason, H.; Nazaroff, B. M.; Connelly, C. D.; Valencic, T.; Ho, M. L.; Tyagi, K.; Beauchamp, J. A.; Pearcey, G. E.
10.1101/2025.06.02.657380 — neuroscience — Posted on 2025-06-05
3705 Cell-surface proteomic profiling identifies CD72 as a regulator of microglial tiling
Chan, T. C.; Rastogi, M.; Williams, M. X.; Zhang, S.; Shi, S. M.; Shuken, S. R.; Bartling, T.; Wild, K.; Atkins, M.; Hahn, O.; Paulo, J. A.; Jereb, S.; Shuster, S. A.; Yoo, Y.; Napole, A.; Hernandez, V. G.; Luo, L.; Buckwalter, M. S.; Stevens, B.; Deverman, B. E.; Kronenberg-Versteeg, D.; Gygi, S. P.; Wyss-Coray, T.; Wernig, M.
10.1101/2025.06.02.657480 — neuroscience — Posted on 2025-06-05
3707 A resource and computational approach for quantifying gene editing allelism at single-cell resolution
Ung, M. H.; Angelini, G.; Wang, R.; Pyclik, A.; Lydeard, J. R.; Ferrucio, J. X.; Lin, M. I.; Chakraborty, T.; Ge, H. G.
10.1101/2025.05.22.653824 — bioinformatics — Posted on 2025-06-05
3710 Plasma insulin-like growth-factor 1 (IGF-1) concentrations predict early life-history traits in a wild mammal
Ravindran, S.; Corripio-Miyar, Y.; Pick, J. L.; Bal, X.; Pilkington, J. G.; Pemberton, J. M.; Nussey, D. H.; Froy, H.
10.1101/2025.06.02.656453 — ecology — Posted on 2025-06-05
3711 Mid-infrared chemical imaging of living cells enabled by plasmonic metasurfaces
Huang, S. H.; Shen, P.-T.; Mahalanabish, A.; Sartorello, G.; Li, J.; Liu, X.; Shvets, G.
10.1101/2024.09.17.613596 — cell biology — Posted on 2025-06-05
3712 Immunofocusing on the conserved fusion peptide of HIV envelope glycoprotein in rhesus macaques
Pratap, P. P.; Cottrell, C. A.; Quinn, J.; Carnathan, D. G.; Bader, D. L. V.; Tran, A. S.; Enemuo, C. A.; Ngo, J. T.; Richey, S. T.; Gao, H.; Shen, X.; Greene, K. M.; Hurtado, J.; Michaels, K. K.; Ben-Akiva, E.; Lemnios, A.; Melo, M. B.; Allen, J. D.; Ozorowski, G.; Crispin, M.; Briney, B.; Montefiori, D.; Silvestri, G.; Irvine, D. J.; Crotty, S.; Ward, A. B.
10.1101/2024.11.27.625755 — immunology — Posted on 2025-06-05
3713 PointTree: Automatic and accurate reconstruction of long-range axonal projections of single-neuron
Cai, L.; Fan, T.; Qu, X.; Zhang, Y.; Gou, X.; Ding, Q.; Feng, W.; Cao, T.; Lv, X.; Liu, X.; Huang, Q.; Quan, T.; Zeng, S.
10.1101/2024.09.23.614432 — neuroscience — Posted on 2025-06-05
3716 Redistribution of fragmented mitochondria ensure symmetric organelle partitioning and faithful chromosome segregation in mitotic mouse zygotes
Gekko, H.; Nomura, R.; Kuzuhara, D.; Kaneyasu, M.; Koseki, G.; Adhikari, D.; Mio, Y.; Carroll, J.; Kono, T.; Funahashi, H.; Wakai, T.
10.1101/2024.06.13.598818 — developmental biology — Posted on 2025-06-05
3717 Novel Adomaviruses Associated with Blotchy Bass Syndrome in Black Basses (Micropterus spp.)
Iwanowicz, L. R.; Raines, C. D.; Young, K. T.; Blazer, V. S.; Walsh, H. L.; Smith, G.; Holt, C.; Odenkirk, J.; Jones, T.; Hessenauer, J.-M.; Biggs, M.; Buck, C. B.; Greer, J.; Cornman, R. S.
10.1101/2025.06.01.657292 — microbiology — Posted on 2025-06-05
3718 Characterization of Sex-Based Differences in Integrin-Mediated Endothelial Cell Adhesion to Bioactive Hydrogels
Nkansah, A.; Budhwani, A.; Grammer, N.; Ang, N.; Fairley, A.; Salazar, S. P.; Anand, A.; Yedalla, A. C.; Seidlits, S.; Allen, J.; Cosgriff-Hernandez, E.
10.1101/2025.06.02.656802 — bioengineering — Posted on 2025-06-05
3719 The impact of RNA chemical probing reagents on RNA binding proteins
Klingler, D.; Fallon, L.; Cohn, D.; Crawford, A.; Marcus, L.; Jones, A. N.
10.1101/2024.03.21.586119 — biochemistry — Posted on 2025-06-05
3721 CBP-IDRs regulate acetylation and gene expression.
Gelder, K. L.; Carruthers, N. A.; Gilbert, G.; Harrison, L. J.; Evans, T.; Ball, S. S.; Dunning, M.; Craggs, T. D.; Twelvetrees, A. E.; Bose, D. A.
10.1101/2024.06.04.597392 — molecular biology — Posted on 2025-06-05
3722 Mutant Huntingtin exon1 protein detected in mouse brain with neoepitope antibody: effects of CAG repeat expansion, MSH3 silencing, and aggregation
Sapp, E.; Boudi, A.; Iwanowicz, A.; Belgrad, J.; Miller, R.; Robertson, R.; O'Reilly, D.; Yamada, K.; Deng, Y.; Joni, M.; Li, X.; Kegel-Gleason, K.; Khvorova, A.; Reiner, A.; Aronin, N.; DiFiglia, M.
10.1101/2024.12.31.630891 — neuroscience — Posted on 2025-06-05
3723 Endothelin B receptor inhibition rescues aging-dependent neuronal regenerative decline
Feng, R.; Rosen, S. F.; Ansari, I.; John, S.; Thomsen, M. B.; Avraham, O.; Geoffroy, C. G.; Cavalli, V.
10.1101/2024.06.08.597928 — neuroscience — Posted on 2025-06-05
3724 Inferring cell dynamics in stress-induced neuroblastoma cell cultures
Hafiichuk, K.; Hamis, S.; Karlsson, J.; Gisselsson, D.; Chattopadhyay, S.
10.1101/2025.03.17.643601 — cancer biology — Posted on 2025-06-05
3725 Making AI accessible for forensic DNA profile analysis
de Wit, A. K. J. G.; Wagenaar, C. D.; Janssen, N. A.; Hoegen, B.; van de Wetering, J.; Hoofs, H.; Ariëns, S.; Benschop, C. C.; Ypma, R. J.
10.1101/2025.06.02.656996 — bioinformatics — Posted on 2025-06-05
3728 Deep learning from videography as a tool for measuring E. coli infection in poultry
Scheidwasser, N.; Poulsen, L. L.; Leow, P. R.; Khurana, M. P.; Iglesias-Carrasco, M.; Laydon, D. J.; Donnelly, C. A.; Bojesen, A. M.; Bhatt, S.; Duchene, D. A.
10.1101/2024.11.20.624075 — animal behavior and cognition — Posted on 2025-06-05
3730 Shola Sky Islands Survey 2025
P, S. M.; L, R. R.; K, S. E.; K, V. C.
10.1101/2025.05.29.656751 — ecology — Posted on 2025-06-05
3731 Cell fate specification during respiratory development requires ARID1A-containing canonical BAF complex activity
Lee, H.; Jaquish, A.; Fernandes, S.; Zhao, B.; Elitz, A.; Cook, K.; Trovillion, S.; Arias, N. M. B.; Han, S.; Goodwin, S.; Russell, N.; Zacharias, A. L.; Brugmann, S. A.; Whitsett, J. A.; Sinner, D. I.; Sun, X. I.; Swarr, D. T.; Zacharias, W. J.
10.1101/2025.06.02.657302 — developmental biology — Posted on 2025-06-05
3736 Perimenopause promotes neuroinflammation in select hippocampal regions in a mouse model of Alzheimers disease
Marongiu, R.; Platholi, J.; Park, L.; Yu, F.; Sommer, G.; Woods, C.; Milner, T. A.; Glass, M. J.
10.1101/2025.03.14.643317 — neuroscience — Posted on 2025-06-05
3737 Leveraging autophagy and pyrimidine metabolism to target pancreatic cancer
Dufresne, S.; Kuna, R. S.; Wong, K.; Komarla, A.; Rock, A.; Rosada-Encarnacion, J.; Shen, C.; Mondal, P.; Parham, L. R.; Layng, F. I.; Peck, K. L.; Fowler, A.; Lowy, A. M.; Engle, D.; Tiriac, H.; Shaw, R.; Cosford, N.; Metallo, C.; Towers, C. G.
10.1101/2025.05.29.656904 — cancer biology — Posted on 2025-06-05
3742 An Evaluation of the Tumor Microenvironment through CALR,IL1R1,IFNB1,and IFNG to Assess Prognosis and Immunotherapy Response in Bladder Cancer Patients
Lilong, L.; Zhenghao, L.; Lei, F.; Zhipeng, Y.; Junyi, H.; Yaxin, H.; Yang, L.; Yuhong, D.; Yingchun, K.; Ke, C.; Yi, H.; Zheng, L.
10.1101/2024.01.24.577030 — immunology — Posted on 2025-06-05
3744 A spatial transcriptomic atlas of acute neonatal lung injury across development and disease severity
Mallapragada, S.; Lyu, R.; Williams-Katek, A. L.; Fischer, B. K.; Vannan, A.; Hadad, N.; Mee, E. D.; Shirazi, S. P.; Jetter, C. S.; Negretti, N. M.; Hilgendorff, A.; Eldredge, L. C.; Deutsch, G. H.; McCarthy, D. J.; Kropski, J. A.; Sucre, J. M. S.; Banovich, N. E.
10.1101/2025.06.02.656433 — genomics — Posted on 2025-06-05
3746 Chronic benzodiazepine treatment triggers gephyrin scaffold destabilization and GABAAR subsynaptic reorganization
Chapman, C. A.; Povysheva, N.; Tarr, T. B.; Nuwer, J. L.; Meriney, S. D.; Johnson, J. W.; Jacob, T. C.
10.1101/2025.06.02.653073 — neuroscience — Posted on 2025-06-05
3750 Oxytocin release modulates acute neuroinflammation and improves brain development after pediatric traumatic brain injury
Knoop, M.; Trak, E.; Possovre, M.-L.; Van de Looij, Y.; Schirmbeck, G.; Ceyzeriat, K.; Pitetti, J.-L.; Farias Sanches, E.; Musardo, S.; Millet, P.; Tsartsalis, S.; Tournier, B. B.; Bellone, C.; Sizonenko, S. V.; Jacquens, A.; Baud, O.
10.1101/2025.06.02.652172 — neuroscience — Posted on 2025-06-05
3753 LOSS OF ARGINASE 2 DISRUPTS STRIATUM-SPECIFIC POLYAMINE HOMEOSTASIS
Nalepa, M.; Basheer, O.; Radkiewicz, M.; Skowronska, K.; Skweres, A.; Owczarek, A.; Dalka, A.; Hilgier, W.; Zielinska, M.; Samborowska, E.; Wegrzynowicz, M.
10.1101/2025.06.02.657391 — neuroscience — Posted on 2025-06-05
3755 iPSC-derived skeletal muscle spheroids for Duchenne Muscular Dystrophy modeling
Esposito, J.; Leite, F. d. S.; Barbosa, I. N.; Martins, T. M. d. M.; Olberg, G. G. d. O.; Tanoury, Z. A.; Telles-Silva, K. A.; Pardo, M. C. d. S.; Jazedje, T.; Bortolin, R. H.; Hirata, M. H.; Pourquie, O.; Zatz, M.
10.1101/2025.06.05.657880 — cell biology — Posted on 2025-06-05
3763 Prediction, Syntax and Semantic Grounding in the Brain and Large Language Models
Koelbl, N.; Rampp, S.; Kaltenhaeuser, M.; Tziridis, K.; Maier, A.; Kinfe, T.; Chavarriaga, R.; Krauss, P.; Schilling, A.
10.1101/2025.06.05.658007 — neuroscience — Posted on 2025-06-05
3769 An ultrasensitive spatial tissue proteomics workflow exceeding 100 proteomes per day
Klingeberg, M.; Krisp, C.; Fritzsche, S.; Schallenberg, S.; Hornburg, D.; Coscia, F.
10.1101/2025.06.02.657389 — systems biology — Posted on 2025-06-05
3770 Contrastive Learning-Enhanced Drug Metabolite Prediction Drives the Discovery of an Orally Bioavailable RSK4 Inhibitor for Esophageal Cancer
He, H.; Zhang, M.; Yang, X.; He, S.; Shi, X.; Hu, F.; Liu, C.; Zhang, X.; Chen, N.; Zhu, X.; Zhang, L.; Ye, T.; Zhang, R.; Yang, Y.; Wang, R.; Zhao, Z.; Chen, Z.; Qian, X.; Li, H.; Wang, Z.; Zhang, K.; Liu, K.; Li, S.
10.1101/2025.06.02.657523 — cancer biology — Posted on 2025-06-05
3771 Hepatocyte expression of fetal insulin receptor isoform contributes to the promotion of liver cancer through non-cell autonomous mechanisms
Leandre, F.; Iddir, A.; Godart, C.; Lagoutte, I.; Caldiero, A.; Souid, S.; Pinto, S.; Augustin, J.; Bou Malham, V.; Alves, A.; Aubry, R.; Imbeaud, S.; Zucman-Rossi, J.; Colnot, S.; Gougelet, A.; Desbois-Mouthon, C.
10.1101/2025.06.02.655477 — cancer biology — Posted on 2025-06-05
3773 Supervised Deep Learning for Efficient Cryo-EM Image Alignment in Drug Discovery with cryoPARES
Sanchez-Garcia, R.; Berndt, A.; Apelbaum, A.; Reeks, J.; Williams, P. A.; Poelking, C.; Deane, C.; Saur, M.
10.1101/2025.03.04.641536 — bioinformatics — Posted on 2025-06-05
3774 Characterization of Sex-Based Differences in Integrin-Mediated Endothelial Cel Adhesion to Bioactive Hydrogels
Nkansah, A.; Budhwani, A.; Grammer, N.; Ang, N.; Fairley, A.; Salazar, S. P.; Anand, A.; Yedalla, A. C.; Seidlits, S.; Allen, J.; Cosgriff-Hernandez, E.
10.1101/2025.06.02.656802 — bioengineering — Posted on 2025-06-05
3775 Precise MRI-Histology Coregistration of Paraffin-Embedded Tissue with Blockface Imaging
Wang, Y.; Ho, W.; Huszar, I. N.; DiGiacomo, P.; Taghavi, H. M.; Tao, L.; Choi, M.; Nguyen, N.; Leventis, S.; Camarillo, D. B.; Schlomer, P.; Axer, M.; Shao, W.; Rusu, M.; Cobos, I.; Nirschl, J.; Georgiadis, M.; Zeineh, M.
10.1101/2025.06.02.657335 — bioengineering — Posted on 2025-06-05
3776 Leech Speciation and Detection of Hirudin Gene among the Leech Population in Asejire Oyo State, Nigeria
Olajide, T. H.; Ajileye, A. O.; Bamikole, O. J.; Olufeagba, M.-d. B.; Adedeji, B. A.; Ademola, S. A.; Amodu, O. k.
10.1101/2025.06.02.657427 — genetics — Posted on 2025-06-05
3779 The Sphingosine-1-phosphate pathway is differentially activated in human gestational tissues.
Mbadhi, M. N.; Fujiwara, H.; Gill, R.; Mitchum, K. T.; Lin, C.; Raghuraman, N.; Frolova, A. I.
10.1101/2025.06.02.657487 — developmental biology — Posted on 2025-06-05
3780 PRPF8-associated retinitis pigmentosa variant induces human neural retina-autonomous photoreceptor defects
Zimmann, F.; Banik, P.; Kubovciak, J.; Thakur, P. K.; Capek, M.; Kolar, M.; Hruba, E.; Dobrovolny, R.; Cvackova, Z.; Barta, T.; Stanek, D.
10.1101/2025.06.04.657822 — cell biology — Posted on 2025-06-05
3784 A dendritic cell population responsible for transglutaminase 2-mediated gluten antigen presentation in celiac disease
Yang, F.-C.; Besser, H. A.; Chun, H. R.; Albertelli, M. A.; Fernandez-Becker, N. Q.; Jabri, B.; Khosla, C.
10.1101/2025.06.02.657527 — immunology — Posted on 2025-06-05
3785 CD14 plays a critical role in pain and inflammation across multiple models of post-traumatic osteoarthritis
Burt, K. G.; South, S. M.; Adamczyk, N. S.; Nguyen, V.; Ishihara, S.; Zhou, C.; Sharp, K. L.; Kim, S. Y.; Rapp, A. E.; Hu, B.; Murphy, L. A.; Hung, L.-Y.; Herbert, D.; Baker, J.; Mauck, R. L.; Griffin, T. M.; Malfait, A.-M.; Miller, R. E.; Scanzello, C. R.
10.1101/2025.06.02.657478 — immunology — Posted on 2025-06-05
3786 Replaying germinal center evolution on a quantified affinity landscape
DeWitt, W. S. S.; Vora, A. A.; Araki, T.; Galloway, J. G.; Alkutkar, T.; Bortolatto, J.; Castro, T. B.; Dumm, W.; Jennings-Schaffer, C.; Jia, T.; Mesin, L.; Ozorowski, G.; Pae, J.; Ralph, D. K.; Bloom, J. D.; Nourmohammad, A.; Song, Y. S.; Ward, A.; Starr, T. N.; Matsen, F. A.; Victora, G. D.
10.1101/2025.06.02.656870 — immunology — Posted on 2025-06-05
3787 A High-Resolution Atlas of the Brain Predicts Lineage and Birth Order Underly Neuronal Identity.
Allen, A. M.; Neville, M. C.; Nojima, T.; Alejevski, F.; Agarwal, D.; Sims, D.; Goodwin, S. F.
10.1101/2025.06.04.657818 — neuroscience — Posted on 2025-06-05
3789 Primary tumor microbiomes predict distant metastasis of colorectal cancer
Parajuli, B.; Midya, V.; Kiddle, R.; De Jager, N.; Eggers, S.; Spakowicz, D.; Hoyd, R.; Salhia, B.; Chan, C. H.; Churchman, M.; Rounbehler, R. J.; Yao, S.; Rutkowski, M. R.; Tarhini, A. A.; Mudaranthakam, D. P.; Masood, A.; Bocklage, T. J.; Lentz, R. W.; Hatoum, H.; Ilozumba, M. N.; Hardikar, S.; Ulrich, C. M.; Round, J. L.; Riedlinger, G.; Shriver, C. D.; Bosch, D. E.
10.1101/2025.06.02.654060 — cancer biology — Posted on 2025-06-05
3790 Biologically-informed machine learning identifies a new clinically-actionable bladder cancer subgroup characterised by NRF2 overactivity
Ungureanu, V. V.; Gawne, R. T.; Baker, S. C.; Eriksson, P.; Halliday, D. M.; Smith, S. L.; Southgate, J.; Mason, A. S.
10.1101/2025.06.03.657659 — cancer biology — Posted on 2025-06-05
3791 Association of GADD45A and favorable outcome in hormone positive breast cancer
Lin, C.-Y.; Liu, C.-Y.; Chao, T.-C.; Huang, C.-C.; Tsai, Y.-F.; Tseng, L.-M.; Lai, J.-I.
10.1101/2025.06.02.657315 — cancer biology — Posted on 2025-06-05
3793 Macrophage-derived reactive oxygen species promote Salmonella aggresome formation contributing to bacterial antibiotic persistence
Chen, X.; Fang, K.; Li, B.; Li, Y.; Ke, Y.; Ke, W.; Tian, T.; Zhao, Y.; Wang, L.; Geng, J.; Leake, M. C.; Bai, F. C.
10.1101/2025.06.03.657582 — biophysics — Posted on 2025-06-05
3797 TCRanalyzer: A user-friendly tool for comprehensive analysis of T-cell diversity, dynamics and potential antigen targets
Seifert, N.; Reinke, S.; Kurz, N. S.; Demmer, J. A.; Kornrumpf, K.; Beissbarth, T.; Klapper, W.; Altenbuchinger, M.
10.1101/2025.05.09.652820 — bioinformatics — Posted on 2025-06-05
3800 Mechanical force-mediated cellular crosstalk maintains the integrity of the lung gas exchange niche
Shen, C.; Morley, M. P.; Zhao, G.; Jones, D. L.; Schaefer, S. E.; Planer, J. D.; Chembazhi, U. V.; Kim, M.; Ying, Y.; Zhou, S.; Li, S.; Hallquist, H.; Lange, A.; Basil, M. C.; Morrisey, E. E.
10.1101/2025.06.04.657878 — cell biology — Posted on 2025-06-05
3801 Caveolin-1 dependent regulation of cell-matrix interphase in 3D collagen gels.
Mazumdar, D.; Kataria, S.; Panda, G. P.; Kulkarni, A.; Patil, S. P. V.; Dash, M.; Balasubramanian, N.
10.1101/2025.06.04.657900 — cell biology — Posted on 2025-06-05
3803 TGF-β serves as a critical signaling determinant of liver progenitor cell fate and function
Tong, C.; Lin, T.; Wang, H.; La Torre, C. D.; Liu, H.; Shao, C.; Hammad, S.; Liebe, R.; Ebert, M. P.; Ding, H.; Dooley, S.; Weng, H.-L.
10.1101/2025.06.04.657336 — cell biology — Posted on 2025-06-05
3804 Senescent mast cells contribute to the progression of benign prostatic hyperplasia via SCF/c-KIT mediated endothelial-mesenchymal transition
Jing, Y.; Li, L.; Guo, W.; Cao, T.; Tang, J.; Zhou, D.; Yao, C.; Xu, J.; Liu, Y.; Feng, C.; Shi, Y.; Wang, M.; Chao, W.; Liao, H.; He, J.; Qin, L.; Luan, J.; Wang, X.; Cui, D.; Zhu, Y.; Ruan, Y.; Xia, S.; Han, B.
10.1101/2025.06.02.657200 — cell biology — Posted on 2025-06-05
3807 Forward genetics in C. elegans reveals genetic adaptations to polyunsaturated fatty acid deficiency
Kaper, D.; Radovic, U.; Bergh, P.-O.; Qvist, A.; Henricsson, M.; Boren, J.; Pilon, M.
10.1101/2024.11.08.622646 — cell biology — Posted on 2025-06-05
3809 Receptor-enriched analysis of functional connectivity (REACT) for understanding cannabinoid neuropsychopharmacology
Shatalina, E.; Ertl, N.; Petrilli, K.; Ofori, S.; Borisova, A.; Mokrysz, C.; Curran, V.; Lawn, W.; Freeman, T. P.; Howes, O.; Wall, M. B.
10.1101/2025.06.02.657387 — neuroscience — Posted on 2025-06-05
3810 Linking offline learning mechanisms to anxiety traits
Yu, Q.; Luo, Y.; Dolan, R. J.; Ou, J.; Huang, C.; Wang, H.; Xiao, Z.; Nour, M.; Liu, Y.
10.1101/2023.06.21.546031 — neuroscience — Posted on 2025-06-05
3811 Network-based Near-Scalp Personalized Brain Stimulation Targets
Kong, R.; Xue, A.; Ooi, L. Q. R.; Asplund, C.; Tan, X. W.; Goh, S. E.; Lee, J. J.; Koh, J. Z. J.; Tan, R. S. Y.; Singh, H. K. G.; Tan, T. W. K.; Webler, R. D.; Fox, M. D.; Siddiqi, S. H.; Tor, P.-C.; Yeo, B. T. T.
10.1101/2025.05.15.654391 — neuroscience — Posted on 2025-06-05
3812 Remodeling of purinergic signaling in the paraventricular hypothalamus promotes hyperphagic obesity and insulin resistance
Liu, Y.; Bondarenko, A.; Zhang, H.; Luan, P.; Zhang, Q.; Wang, B.; Najam, S. S.; Liang, X.; Syed, A. A. S.; Lin, D.; Huang, S.; Konovalov, R.; Konopka, W.; Zhang, Z.; Zhang, Y.; Wu, S.; Jing, M.; Vinnikov, I. A.
10.1101/2024.07.02.601503 — neuroscience — Posted on 2025-06-05
3813 OPM quantum sensors enhance non-invasive neuroimaging performance
Brickwedde, M.; Anders, P.; Krueger, P.; Sander, T.; Uhlhaas, P.
10.1101/2025.05.30.657044 — neuroscience — Posted on 2025-06-05
3814 Prognostic significance of Ki-67, BAX, Caspase-3, and VEGF expression in feline intestinal lymphoma
Faraldo, N. C.; Rosenfeld, A. d. F. S.; Brombatti, K. G.; Amorim, R. L.; Battaglia, S. T. H.; Sobral, R. A.; Fonseca Alves, C. E.
10.1101/2025.06.01.657294 — pathology — Posted on 2025-06-05
3817 Depth-resolved fiber photometry of amyloid plaque signals in freely behaving Alzheimer's disease mice
Byron, N.; McAlinden, N.; Pisano, F.; Pisanello, M.; Ferreira, J.; Montinaro, C.; Mathieson, K.; De Vittorio, M.; Pisanello, F.; Sakata, S.
10.1101/2025.04.08.647900 — neuroscience — Posted on 2025-06-05
3818 Col6 deficiency in a zebrafish model of Bethlem myopathy leads to dysfunction of the muscle dihydropyridine receptor
Idoux, R.; Exbrayat-Heritier, C.; Shivaraman, S.; Jaque-Fernandez, F.; Ducret, A.; Berthier, C.; Jacquemond, V.; Sohm, F.; bretaud, s.; Ruggiero, F.; ALLARD, B.
10.1101/2025.06.02.657388 — pathology — Posted on 2025-06-04
3820 The mutational dynamics of the Arabidopsis centromeres
Dong, X.; Jiao, W.-B.; Campoy, J. A.; Rabanal, F. A.; Ton, J.; Smith, L. M.; Weigel, D.; Schneeberger, K.
10.1101/2025.06.02.657473 — genomics — Posted on 2025-06-04
3823 Persistent cortical excitatory neuron dysregulation in adult Chd8 haploinsufficient mice.
Canales, C. P.; Lozano, S.; Frost, N. A.; Cichewicz, K.; Amaral, W.; Seban, N.; Fenton, E.; Wade, A.; Chu, N.; Smith, E.; Ardekani, C.; Frank, S.; Bennett, J.; Lavenex, P.; Kopley-Smith, A.; Rahbarian, D.; Corea, M.; Perla, D.; Davis, L.; Zhu, J.; Ortiz, R.; Beauregard, P.; Moyer, C.; Baker, J.; Sun, J.; Ma, B.; Lu, J.; Sohal, V. S.; Amaral, D. G.; Zuo, Y.; Nord, A. S.
10.1101/2025.06.04.657776 — genomics — Posted on 2025-06-04
3824 Single-nucleus epigenomic dysregulation unmasks genetic risk-associated neurodegenerative glia states
Han, X.; Zhang, T.; Lee, C.-Y.; Ravi, A.; Spina, S.; Li, A. N.; Grinberg, L. T.; Seeley, W. W.; Huckins, L. M.; Raj, T.; Brennand, K. J.; Rexach, J. E.
10.1101/2025.06.02.657512 — genomics — Posted on 2025-06-04
3825 The Insertion of an ATTTC Repeat in an Alu Element Hyperactivates a Primate-Specific Neurodevelopmental Enhancer in Spinocerebellar Ataxia Type 37
Loureiro, J. R.; Castro, A. F.; Figueiredo, A. S.; Eufrasio, A.; Dhingra, A.; Galhardo, M.; Marcelino, H.; Rodrigues, C.; Sampaio, P.; Azevedo, M. M.; Sousa, M.; Doria, S.; Rizzu, P.; Heutink, P.; Bessa, J.; Silveira, I.
10.1101/2025.06.03.657633 — genetics — Posted on 2025-06-04
3827 Malaria shaped human spatial organisation for the last 74 thousand years
Colucci, M.; Leonardi, M.; Blinkhorn, J.; Irish, S. R.; Padilla-Iglesias, C.; Kaboth-Bar, S.; Gosling, W. D.; Snow, R. W.; Manica, A.; Scerri, E. M. L.
10.1101/2025.06.04.657870 — evolutionary biology — Posted on 2025-06-04
3828 Sp Transcription Factors Establish the Signaling Environment in the Neuromesodermal Progenitor Niche During Axial Elongation
Chalamalasetty, R. B.; Tran, H.; Kelly, R.; Kuo, S.; Kennedy, M. W.; Lee, M.; Thomas, S.; Mandalos, N.; Koparde, V.; Pereira Lobo, F.; Yamaguchi, T. P.
10.1101/2025.06.03.657492 — developmental biology — Posted on 2025-06-04
3829 Cell fate specification during respiratory development requires ARID1A-containing canonical BAF complex activity
Lee, H.; Jaquish, A.; Fernandes, S.; Zhao, B.; Elitz, A.; Cook, K.; Trovillion, S.; Arias, N. M. B.; Han, S.; Goodwin, S.; Russell, N.; Zacharias, A. L.; Brugmann, S. A.; Whitsett, J. A.; Sinner, D. I.; Sun, X. I.; Swarr, D. T.; Zacharias, W. J.
10.1101/2025.06.02.657302 — developmental biology — Posted on 2025-06-04
3830 Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying SCN2A mutation
Wu, J.; Chen, X.; Zhang, J.; Wettschurack, K. W.; Robinson, M. J.; Li, W.; Zhao, Y.; Yoo, Y.-E.; Deming, B. A.; Abeyaratna, A. D.; Que, Z.; Du, D.; Tegtmeyer, M. T.; Yuan, C.; Skarnes, W. C.; Rochet, J.-C.; Wu, L.-J.; Yang, Y.
10.1101/2025.06.04.657874 — neuroscience — Posted on 2025-06-04
3835 Artemether and Euphorbia Factor L9 suppress kynurenine production through distinct effects on Tryptophan metabolism.
Capatina, A. L. L.; Czechowski, T.; Plunkett-Jones, C.; Tonon, T.; Kourtzelis, I.; Lichman, B. R.; Brackenbury, W. J.; Graham, I. A.; Lagos, D.
10.1101/2025.06.02.657401 — cancer biology — Posted on 2025-06-04
3840 Functional insights into the photoactive yellow protein family from homologs, multidomain proteins and inferred pyp operons
Dohmen, R.; Hoogerwerf, G.; Dohmen, A. J.; Neal, M. L.; Bradley, C.; Huffman, C.; Teeman, S. M.; Hampton, S. F.; Powell, S.; Gunn, Z.; Hoff, W. D.
10.1101/2025.06.04.657921 — microbiology — Posted on 2025-06-04
3841 Desiccation-induced DNA damage facilitates drug resistance in Mycobacterium tuberculosis
Brown, C. D.; Lee, B. M.; Liu, H.; Wu, A.; Tellez, A. V.; Zou, H.; Singh, P.; Saito, K.; Mishra, S.; Brown, M.; Saleh, A.; Odjourian, N. M.; Cristaldo, M.; Gan, M.; Liu, Q.; Gengenbacher, M.; Darst, S. A.; Campbell, E. A.; Nathan, C. F.; Rhee, K. Y.
10.1101/2025.06.04.657859 — microbiology — Posted on 2025-06-04
3843 Cell-free genome-wide transcriptomics through machine learning optimization
Wagner, L.; HOANG, A.; RUE, O.; Delumeau, O.; Loux, V.; Faulon, J.-L.; Jules, M.; Borkowski, O.
10.1101/2025.06.04.657821 — synthetic biology — Posted on 2025-06-04
3844 Plasmodium falciparum subverts neutrophil function via host miR-451a loaded extracellular vesicles driving bacterial superinfection susceptibility
Babatunde, K. A.; Ngara, M.; Martinez Murillo, P.; Subramanian, B.; Hopke, A.; Lucchesi, S.; Novedrati, M.; Montesi, G.; Santoro, F.; Hagemann-Jensen, M.; Sandberg, R.; Filgueira, L.; Irimia, D.; Walch, M.; Mantel, P.-Y.
10.1101/2025.06.02.657463 — immunology — Posted on 2025-06-04
3845 Inter-individual variability in immune responses to AAV-mediated ocular gene delivery across species impedes reliable immunomonitoring profile
REN, D.; CHAUVEAU, G.; VENDOMELE, J.; CABON, E.; PINEIRO, A.; VIGNAL-CLERMONT, C.; SALIBA, H.; RONZITTI, G.; GALY, A.; DALKARA, D.; PULMAN, J.; AIL, D.; FISSON, S.
10.1101/2025.06.02.656863 — immunology — Posted on 2025-06-04
3847 Platelet concentrate-derived extracellular vesicles promote adult hippocampal neurogenesis
NyamErdene, A.; Thao Ngoc Le, N.; Nebie, O.; Faivre, E.; Delila, L.; Chou, M. L.; Lowe, J.; Bantubungi, K.; Buee, L.; Walker, T.; Blum, D.; Burnouf, T.
10.1101/2025.04.29.651163 — neuroscience — Posted on 2025-06-04
3849 Towards Unmanned Proteomics Data Generation: A Fully Automated Sample-to-Data System for Proteomic Experiments
Wang, D.; Chen, W.; Xie, L.; Xu, Y.; Huang, C.; Liu, Y.; Wang, X.; Huang, X.; Zhang, K.; Pan, M.; Wang, S.; Qin, B.; Yang, Y.; Yang, J.; Tang, L.; Tian, R.; He, F.
10.1101/2025.06.02.656978 — biochemistry — Posted on 2025-06-04
3852 Structural insights into context-specific inhibition of bacterial translation by macrolides
Syroegin, E. A.; Aleksandrova, E. V.; Kruglov, A. A.; Paranjpe, M. N.; Svetlov, M. S.; Polikanov, Y. S.
10.1101/2025.06.03.657637 — molecular biology — Posted on 2025-06-04
3853 Human cytomegalovirus-encoded G protein-coupled receptor (GPCR), UL78, regulates viral reactivation
Osanyinlusi, S. A.; Baruah, V.; Groves, I. J.; Kulp, K. H.; Krishna, B. A.; O'Connor, C. M.
10.1101/2025.06.04.657869 — microbiology — Posted on 2025-06-04
3855 Gut microbiota of Brazilian Melipona stingless bees: dominant members and their localization in different gut regions
Tristao Santini, A.; Cerqueira, A. E. S.; Moran, N. A.; Resende, H. C.; Santana, W. C.; de Paula, S. O.; da Silva, C. C.
10.1101/2025.06.03.657762 — microbiology — Posted on 2025-06-04
3856 Identification of a Broadly Acting Inhibitor of the Alphavirus Non-Structural Protein 2 Helicase
Sears, J. D.; Ojha, D.; Taft-Benz, S.; Sylvester, P. A.; Streblow, Z.; Gramm, A. J.; Drobish, A. M.; Ramalingam, B. M.; Hossain, M. A.; Talbot, K. M.; Sanders, W.; Chang, C.-K.; Law, I.; Martinez, S. A.; Burdick, J. E.; Wiltshire, R.; Saba, N. A.; Poplarski, J. H.; Counago, R. M.; Brown, P. J.; Anand, G. S.; Morrison, T. E.; Arnold, J. J.; Cameron, C. E.; Streblow, D. N.; Willson, T. M.; Heise, M. T.; Moorman, N. J.
10.1101/2025.06.03.657755 — microbiology — Posted on 2025-06-04
3858 Common and distinct neural correlates of social interaction perception and theory of mind
Miao, Z.; Jung, H.; Kragel, P. A.; Bo, K.; Sadil, P.; Lindquist, M. A.; Wager, T. D.
10.1101/2024.12.19.628993 — neuroscience — Posted on 2025-06-04
3860 An artificial nervous system for communication between wearable and implantable therapeutics
Ghanim, R.; Lee, Y. J.; Byun, G.; Jackson, J.; Ding, J. Z.; Feller, E.; Kim, E.; Aygun, D.; Kaushik, A.; Cig, A.; Park, J.; Healy, S.; Cunin, C. E.; Gumyusenge, A.; Yeo, W. H.; Abramson, A.
10.1101/2025.06.04.657863 — bioengineering — Posted on 2025-06-04
3861 Perilipin 4 repetitive region forms amyloid fibrils promoted by a genetic expansion found in myopathy patients
Choufani, C.; Fuggetta, N.; Sabbagh, B.; Moulin, C.; Franckhauser, C.; Lyonnais, S.; Perme, T.; Arteni, A.-A.; Pagnotta, S.; Rouquier, S.; Ruggieri, A.; Bousset, L.; Copic, A.
10.1101/2025.06.03.657256 — biochemistry — Posted on 2025-06-04
3862 Assembly and phospho-regulatory mechanisms of the budding yeast outer kinetochore KMN complex
Turner, N. N.; Zhang, Z.; Muir, K. W.; McLaughlin, S. H.; Morgan, T.; Barford, D.
10.1101/2025.06.03.657598 — biochemistry — Posted on 2025-06-04
3864 PKP2 orchestrates OXPHOS expression in cardiomyocytes via a PGC1α-dependent mechanism
Han, S. J.; den Berg, D.; de Ruiter, H.; Tsui, H.; Kyriakopoulou, E.; Koopmans, T.; Perini, I.; Monshouwer-Kloots, J.; van Kampen, S. J.; te Riele, A. S. J. M.; Kelters, I. R.; Gianoli, M.; Burgering, B. M. T.; van Rooij, E.
10.1101/2025.06.02.656790 — molecular biology — Posted on 2025-06-04
3865 Clinical Trypanosoma cruzi isolates share a common antigen repertoire that is absent from culture adapted strains
Hakim, J. M. C.; Gutierrez Guarnizo, S. A.; Duran, A.; Malaga-Machacha, E.; Duque, C.; Singer, L.; Colanzi, R.; Sherbuk, J. E.; Gilman, R.; Bern, C.; Messenger, L. A.; Mugnier, M. R.; Working Group on Chagas Disease in Bolivia and Peru,
10.1101/2025.06.04.657671 — microbiology — Posted on 2025-06-04
3868 R-Spondin Mimetic, SZN-043, Induced Proliferation and Expression of Wnt Target Genes, Two Impaired Features in Human Alcohol-Associated Liver Disease
Fisher, T.; Patel, M.; Deshmukh, S.; Shah, D.; Lu, C.; Newman, M.; Ye, J.; Fletcher, R.; Vanhove, G. F.; Tibbitts, J.; Li, Y.; Skill, N. J.; Yang, Z.; Liangpunsakul, S.; Baribault, H.
10.1101/2024.11.19.624277 — pathology — Posted on 2025-06-04
3872 The evolution of separate sexes in waterhemp is associated with surprising chromosomal diversity and complexity
Kreiner, J. M.; Montgomery, J. S.; Todesco, M.; Bercovich, N.; Gong, Y.; Elphinstone, C.; Tranel, P. J.; Rieseberg, L. H.; Wright, S. I.
10.1101/2024.09.17.613486 — evolutionary biology — Posted on 2025-06-04
3875 Efficient Generation of Expandable Dorsal Forebrain Neural Rosette Stem Cell Lines
Frazier, S. E. D.; de Lichtenberg, K. H.; Jaberi, E.; Bertelsen, C.; Jensen, S. M.; Wrona, A.; Christophersen, N. S.; Kristensen, M.; Villaescusa, J. C.
10.1101/2025.05.27.656305 — neuroscience — Posted on 2025-06-04
3876 Population structure of Phytophthora infestans collected from potatoes in Guatemala and Honduras
Izarra, M. L.; Perez, W. G.; Vasquez, E. F.; Perez, G. E.; Gamboa, S.; Andrade-Piedra, J.; Flores, B.; Montejo, L.; Sanders, A.; Kreuze, J. F.
10.1101/2025.05.28.656702 — pathology — Posted on 2025-06-04
3877 Reconciling the effects of PMS2 in different repeat expansion disease models supports a common therapeutic strategy
Jimenez, D. A.; Miller, C. J.; Walker, A.; Anupindi, K.; Hayward, B. E.; Lorenzi, H. A.; Usdin, K.; Zhao, X.
10.1101/2024.08.13.607839 — genetics — Posted on 2025-06-04
3880 3D Quantification of Viral Transduction Efficiency in Living Human Retinal Organoids
Rogler, T. S.; Salbaum, K. A.; Brinkop, A. T.; Sonntag, S. M.; James, R.; Shelton, E. R.; Thielen, A.; Rose, R.; Babutzka, S.; Klopstock, T.; Michalakis, S.; Serwane, F.
10.1101/2024.03.06.583795 — neuroscience — Posted on 2025-06-04
3882 The intratumoral microbiome is negatively associated with malignancy in dermatofibrosarcoma protuberans
Jian, X.; Liu, Z.; Zhang, J.; Li, Y.; Xie, L.; Zhao, G.; Li, B.; Li, J.; Peng, C.; Wan, M.; Chen, X.
10.1101/2025.06.02.657449 — microbiology — Posted on 2025-06-04
3883 The hemagglutinin proteins of clades 1 and 2.3.4.4b H5N1 highly pathogenic avian influenza viruses exhibit comparable attachment patterns to avian and mammalian tissues
Zhu, B.; Fung, K.; Feng, H. H.; Beatty, J. A.; Hill, F.; Tse, A. C.; Brackman, C. J.; Sit, T. H.; Poujade, A.; Gaide, N.; Ducatez, M.; Foucras, G.; Peiris, M.; Ti, S.-C.; Nicholls, J. M.; Yen, H.-L.
10.1101/2025.06.02.657404 — microbiology — Posted on 2025-06-04
3884 Evolutionary trajectories determine the feasibility of collateral sensitivity based antibiotic treatment strategies in critical bacterial pathogens
Brandis, G.; Chauhan, V.; Enkvist, L.; Chukhareva, Y.; Damell, C.; Cruz Davila, E.; Islam, T. M.; Melander, G.; Paulsson, E.; Sundell, A.; Zweifel, E.; Knöppel, A.
10.1101/2025.06.03.657621 — microbiology — Posted on 2025-06-04
3887 eIF4G2-Mediated Translation Initiation of Histone Modifiers Is Essential for Intestinal Stem Cell Maintenance and Differentiation
Kunitomi, H.; Khaine, A. M.; Jamee, R.; Arreola, V.; Lancero, M.; Raychaudhuri, A.; Perli, S. D.; Sato, Y.; Iwasaki, M.; Ruivo, P. R.; Tomoda, K.; Mito, M.; Shichino, Y.; Iwasaki, S.; Yamanaka, S.
10.1101/2025.05.19.652834 — cell biology — Posted on 2025-06-04
3888 Z-Form Stabilization By The Zα Domain Of Adar1p150 Has Subtle Effects On A-To-I Editing
Nichols, P. J.; Riemondy, K. A.; Krall, J. B.; Ramos, J.; Goering, R.; Henen, M. A.; Taliaferro, J. M.; Vogeli, B.; Vicens, Q.
10.1101/2025.06.02.657529 — cell biology — Posted on 2025-06-04
3889 Dendritic computation for rule-based flexible categorization
Zhang, Y.; Liu, Y.; Hu, Y.; Zhang, Z.; Du, J.; Cui, L.; Liu, Q.; Zhong, L.; Xin, Y.; Chai, R.; Deng, L.; Pan, J.; Schiller, J.; Xu, N.-l.
10.1101/2025.06.03.657766 — neuroscience — Posted on 2025-06-04
3891 MRAP2 modifies signaling and oligomerization state of the melanocortin-4 receptor
Sohail, I.; Laurin, S.-A.; Kleinau, G.; Chunilal, V.; Morton, A.; Brenlla-Lopez, A.; Kagiali, Z. C. U.; Tello, J. A.; Blouin, M.-J.; Beck-Sickinger, A. G.; Lohse, M. J.; Scheerer, P.; Bouvier, M.; McCormick, P.; Annibale, P.; Biebermann, H.
10.1101/2024.04.09.588099 — pharmacology and toxicology — Posted on 2025-06-04
3894 A heterogeneous pharmaco-transcriptomic landscape induced by targeting a single oncogenic kinase
Giglio, R. M.; Hou, N.; Wyatt, A.; Hong, J.; Shi, L.; Vaikunthan, M.; Fuchs, H.; Nima, J. P.; Malinowski, S. W.; Ligon, K. L.; McFaline-Figueroa, J. R.; Yosef, N.; Azizi, E.; McFaline-Figueroa, J. L.
10.1101/2024.04.08.587960 — genomics — Posted on 2025-06-04
3897 Dendritic computation for rule-based flexible categorization
Zhang, Y.; Hu, Y.; Zhang, Z.; Du, J.; Cui, L.; Liu, Q.; Zhong, L.; Xin, Y.; Chai, R.; Deng, L.; Pan, J.; Schiller, J.; Xu, N.-l.
10.1101/2025.06.03.657766 — neuroscience — Posted on 2025-06-04
3898 A model of the cerebellum generates gait adaptations in a reflex-based neuromusculoskeletal model during split-belt walking
Fleischmann, S.; Shanbhag, J.; Miehling, J.; Wartzack, S.; Ong, C.; Eskofier, B. M.; Koelewijn, A. D.
10.1101/2024.12.12.628122 — neuroscience — Posted on 2025-06-04
3902 Molecular Phenotypic Plasticity Informs Possible Adaptive Change of Triple-Negative Breast Cancer Cells In Vivo
Iftehimul, M.; Muganda, P. M.; Newman, R. H.; Rorie, C. J.; Harrison, S. H.; Hossain, M. T.; Thomas, M. D.; Graves, J. L.; Saha, D.
10.1101/2025.05.31.657204 — cancer biology — Posted on 2025-06-04
3905 Investigating the consequences of the mating system for drug resistance evolution in C. elegans
Trubenova, B.; Hellinga, J.; Krücken, J.; von Samson-Himmelstjerna, G.; Schulenburg, H.; Regoes, R. R.
10.1101/2024.11.07.620884 — evolutionary biology — Posted on 2025-06-04
3906 Long-term surveillance suggests multiple hybridization events by nuclear reassortment and accelerated intercontinental spread of wheat yellow rust
Hovmoeller, M. S.; Thach, T.; Algaba, J. R.; Hansen, J. G.; Meyer, M.; Hodson, D.; Nazari, K.; Park, R. R.; Tamm, R.; Moeller, M.; Schwessinger, B.; Rathjen, J. P.; Silva, P.; Riella, V.; Justesen, A. F.
10.1101/2025.05.22.655633 — evolutionary biology — Posted on 2025-06-04
3908 Genetic interaction library screening with a next-generation dual guide CRISPR system
Burgold, T.; Karakoc, E.; Goncalves, E.; Barrio-Hernandez, I.; Dwane, L.; Silva, R. O.; Souster, E.; Sharma, M.; Beck, A.; Koh, G.; Zalmas, L.-P.; Garnett, M.; Bassett, A. R.
10.1101/2024.03.28.587052 — molecular biology — Posted on 2025-06-04
3912 Kinetic-model-guided engineering of multiple S. cerevisiae strains improves p-coumaric acid production
Narayanan, B.; Jiang, W.; Wang, S.; Saez-Saez, J.; Weilandt, D. R.; Masid, M.; Hesselberg-Thomsen, V.; Borodina, I.; Hatzimanikatis, V.; Miskovic, L.
10.1101/2024.12.15.628543 — systems biology — Posted on 2025-06-04
3913 Defense-Suppressive Fragments of RIN4 generated by AvrRpt2 Participate in NDR1-dependent Activation of RPS2
Afzal, A. J.; Alam, M.; Huang, J.; Agha, M.; Da Cunha, L.; Iqbal Rai, M.; Tahir, J.; Jamroze, A.; Jones, J. D.; Mackey, D.
10.1101/2025.06.02.656948 — plant biology — Posted on 2025-06-04
3914 Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche
Masson, C.; Scandola, C.; Rinckel, J.-Y.; Proamer, F.; Janus-Bell, E.; Batool, F.; OSMANI, N.; GOETZ, J. G.; Mallo, L.; Brouard, N.; Leon, C.; Bornert, A.; Poincloux, R.; Destaing, O.; Mansson, A.; QIAN, H.; Lehmann, M.; Eckly, A.
10.1101/2024.09.30.615769 — physiology — Posted on 2025-06-04
3916 Microbial hydrocarbon degradation potential of the Baltic Sea ecosystem
Serrana, J. M.; Dessirier, B.; Nascimento, F. J. A.; Broman, E.; Posselt, M.
10.1101/2025.06.02.657333 — ecology — Posted on 2025-06-04
3918 ONE-STEP tagging: a versatile method for rapid site-specific integration by simultaneous reagent delivery
Migliori, V.; Bruntraeger, M.; Gyulev, I.; Lichou, F.; Burgold, T.; Gitterman, D.; Iwama, S.; Trinh, A.; Washer, S. J.; Jones, C.; Trynka, G.; Bassett, A. R.
10.1101/2024.08.29.610246 — molecular biology — Posted on 2025-06-04
3919 cGAS-STING dependent type I IFN protects against Leptospira interrogans renal colonization in mice.
Gupta, S.; Matsunaga, J.; Ratitong, B.; Ismaeel, S.; Valadares, D.; West, P.; Kerur, N.; Stehlik, C.; Dorfleutner, A.; Dagvadorj, J.; Coburn, J.; Wolf, A.; Cassel, S.; Haake, D.; Sutterwala, F. S.
10.1101/2025.06.02.657349 — immunology — Posted on 2025-06-04
3920 Memory by a thousand rules: Automated discovery of multi-type plasticity rules reveals variety and degeneracy at the heart of learning.
Confavreux, B.; Harrington, Z.; Kania, M.; Ramesh, P.; Krouglova, A. N.; Bozelos, P. A.; Macke, J. H.; Saxe, A. M.; Goncalves, P. J.; Vogels, T. P.
10.1101/2025.05.28.656584 — neuroscience — Posted on 2025-06-04
3923 Pasta, an age-shift transcriptomic clock, maps the chemical and genetic determinants of aging and rejuvenation
Salignon, J.; Tsiokou, M.; Marques, P.; Rodriguez-Diaz, E.; Ang, H.; Pietrocola, F.; Riedel, C. G.
10.1101/2025.06.04.657785 — bioinformatics — Posted on 2025-06-04
3924 REnformer, a single-cell ATAC-seq predicting model to investigate open chromatin sites
Riva, S. G.; Sanders, E.; Wilson, T.; Stranieri, N.; Gur, R.; Baxter, M.; Hughes, J. R.
10.1101/2025.06.04.657786 — bioinformatics — Posted on 2025-06-04
3927 Multiscale radiobiological assessment of laser-driven very high energy electrons versus conventional electrons
Giaccaglia, C.; Bayart, E.; Dubail, M.; Varma, C.; Heinrich, S.; Gautier, J.; Tafzi, A.; Kononenko, O.; Goddet, J.-p.; Lamarre-Jouenne, I.; Fouillade, C.; Flacco, A.
10.1101/2025.05.27.656200 — cell biology — Posted on 2025-06-04
3928 JADE family proteins regulate proteasome abundance and activity
Ebert, L. K.; Bargfrede, S.; Bohl, K.; Cohen, H.; Mueller, R.-U.; Benzing, T.; Schermer, B.
10.1101/2021.10.01.462752 — cell biology — Posted on 2025-06-04
3930 Cytokine expression profile in the human brain of older adults
Godoy, J. B.; Vialle, R. A.; dos Santos, L.; Raittz, R. T.; Wang, Y.; Menon, V.; De Jager, P.; Schneider, J. A.; Tasaki, S.; Bennett, D. A.; Guizelini, D.; Lopes, K.
10.1101/2025.06.02.657444 — molecular biology — Posted on 2025-06-04
3931 Focused ultrasound neuromodulation of mediodorsal thalamus disrupts decision flexibility during reward learning
Mackenzie, G.; Gilmour, W.; Yang, S. S.; Suveges, S.; MacFarlane, J.; Kanodia, A.; Manfield, J.; Khan, S.; Osman-Farah, J.; Marcerolo, A.; Steele, D.; Gilbertson, T.
10.1101/2025.06.03.657634 — neuroscience — Posted on 2025-06-04
3933 Dendritic computation for rule-based flexible categorization
Xu, N.-l.; Zhang, Y.; Hu, Y.; Zhang, Z.; Du, J.; Cui, L.; Liu, Q.; Zhong, L.; Xin, Y.; Chai, R.; Deng, L.; Pan, J.; Schiller, J.
10.1101/2025.06.03.657766 — neuroscience — Posted on 2025-06-04
3935 PANDA: A simple and affordable chamber system for measuring the whole-plant net CO2 flux
Schuler, P.; Li, Y.; Pittet, P.; Favre, P.; Li, M.-H.; Zhang, Y.-L.; Grossiord, C.
10.1101/2025.06.02.657330 — plant biology — Posted on 2025-06-04
3936 Loss of UFMylation supports prostate cancer metastasis and rewires cell metabolism towards hexosamine biosynthesis
Bozal Basterra, L.; Salazar Palacio, M. C.; Ferreira Campos, A. M.; Demicco, M.; Schmidt, D. R.; Sobczak, K.; Ereno-Orbea, J.; Altea Manzano, P.; Miranda Villanueva, A.; Martinez La Osa, B.; Garcia-Longarte, S.; Ponce Rodriguez, M.; Mendizabal, I.; Carlevaris Lopez, O.; Astobiza, I.; Martin Martin, N.; Zabala-Letona, A.; Talamillo, A.; Fernandez Garcia, J.; Azkargorta, M.; Iloro, I.; Barrio, R.; Elortza, F.; Fendt, S. M.; Vander Heiden, M. G.; Jimenez Barbero, J.; D. Sutherland, J.; Carracedo, A.
10.1101/2025.06.02.657324 — cancer biology — Posted on 2025-06-04
3937 Data-driven symbolic regression reveals microbial growth laws
Sun, T. A.; Kiciatovas, D.; Aapalampi, I.-K.; Kuosmanen, T.; Hiltunen, T.; Mustonen, V.
10.1101/2025.06.02.657040 — ecology — Posted on 2025-06-04
3938 A new resource of clonal pluripotent human stem cell lines exhibiting inter- and intra-embryo consistency and variability
Strawbridge, S. E.; Bates, L. E.; Ross, C.; Jones, K. A.; Azami, T.; Lohoff, T.; Paramor, M.; Murray, V.; Cidral, A. L.; Clarke, J.; Rostovskaya, M.; Guo, G.; Nichols, J.
10.1101/2025.06.02.657331 — developmental biology — Posted on 2025-06-04
3940 Towards Unified Neural Decoding with Brain Functional Network Modeling
Wu, D.; Bu, L.; Jia, Y.; Cao, L.; Li, S.; Zhou, Y.; Fan, S.; Ren, W.; Wu, D.; Wang, K.; Zhang, Y.; Ma, Y.; Yang, J.; Mohamad, S.
10.1101/2025.06.02.657011 — neuroscience — Posted on 2025-06-04
3942 NF-κB is a Central Regulator of Hypoxia-Induced Gene Expression
Shakir, D.; Batie, M.; Kwok, C.-S.; Cook, S. J.; Kenneth, N. S.; Rocha, S.
10.1101/2025.01.08.631917 — molecular biology — Posted on 2025-06-04
3943 RNAi epimutations conferring antifungal drug resistance are inheritable
Perez-Arques, C.; Navarro-Mendoza, M. I.; Xu, Z.; Walther, G.; Heitman, J.
10.1101/2024.10.15.618540 — microbiology — Posted on 2025-06-04
3946 Single-cell morphological profiling reveals insights into programmed cell death
Frey, B.; Holmberg, D.; Bystrom, P.; Bergman, E.; Georgiev, P.; Johansson, M. M.; Hennig, P.; Rietdijk, J.; Rosen, D.; Carreras-Puigvert, J.; Spjuth, O.
10.1101/2025.01.15.633042 — bioinformatics — Posted on 2025-06-04
3947 Population-scale inheritance analysis of 858,635 individuals reveals North Sea migration from the Middle Ages to the Industrial Revolution
Zhang, X.; Holm, P.; Scally, A.; Banasik, K.; Mortensen, L. H.; Fitzgerald, T. W.; Westergaard, D.; Chmura, P. J.; Ostrowski, S. R.; Sorensen, E.; Pedersen, O. B. V.; Schwinn, M.; Erikstrup, C.; Bruun, M. T.; Jensen, B. A.; Ullum, H.; Mikkelsen, C.; Hansen, T. F.; DBDS Genetic Consortium, ; Stefansson, K.; Brunak, S.; Birney, E.
10.1101/2025.03.19.643007 — genetics — Posted on 2025-06-04
3949 PROTRIDER: Protein abundance outlier detection from mass spectrometry-based proteomics data with a conditional autoencoder
Klaproth-Andrade, D.; Scheller, I.; Tsitsiridis, G.; Loipfinger, S.; Mertes, C.; Smirnov, D.; Prokisch, H.; Yepez, V.; Gagneur, J.
10.1101/2025.02.01.636024 — bioinformatics — Posted on 2025-06-04
3951 Aedes albopictus is rapidly invading its climatic niche in France: wider implications for biting nuisance and arbovirus control in Western Europe
Radici, A.; Hammami, P.; Cannet, A.; L'Ambert, G.; Lacour, G.; Fournet, F.; Garros, C.; Guis, H.; Fontenille, D.; Caminade, C.
10.1101/2025.02.14.638223 — ecology — Posted on 2025-06-04
3954 OPM quantum sensors enhance non-invasive neuroimaging performance
Brickwedde, M.; Anders, P.; Krueger, P.; Sander, T.; Uhlhaas, P.
10.1101/2025.05.30.657044 — neuroscience — Posted on 2025-06-04
3955 Valence of sensory stimulation as a key feature for subcortical entrainment: Insights from human intracranial EEG
Hoyer, R. S.; Bernier, M.-F.; Martineau, L.; Lessard Bonaventure, P.; Labelle, C.; Borderie, A.; Blanchette, I.; Blumenthal, A.; Laureys, S.; Albouy, P.
10.1101/2025.01.03.631218 — neuroscience — Posted on 2025-06-04
3958 Butterfly wing iridescence is regulated by araucan, a direct target of Optix and Spalt
Chatterjee, M.; Finet, C.; Siegel, K. J.; Loh, L. S.; Delgado, S.; McDonald, J. M. C.; Markenscoff-Papadimitriou, E.; Monteiro, A.; Reed, R. D.
10.1101/2023.11.21.568172 — genetics — Posted on 2025-06-03
3961 Human brain network control of creativity
Rabinovich, R.; Cowan, R. L.; Libowitz, M.; Davis, T.; Rahimpour, S.; Beaty, R.; Bartoli, E.; Sheth, S.; Smith, E. H.; Shofty, B.
10.1101/2025.06.03.657648 — neuroscience — Posted on 2025-06-03
3963 Spatiotemporal Dynamics of Invariant Face Representations in the Human Brain
Giri, A.; Smith, G.; Manting, C. L.; Dobs, K.; Adler, A.; Pantazis, D.
10.1101/2025.06.03.657646 — neuroscience — Posted on 2025-06-03
3966 Enzyme Activity Regulates Substrate Diffusion by Modulating Viscosity in Crowded Milieu
Bevilacqua, A.; Maciel, M. R.; Sullivan, M. V.; Pascarelli, S.; Dindo, M.; Shen, A. Q.; Laurino, P.
10.1101/2024.09.28.615560 — biochemistry — Posted on 2025-06-03
3968 The Balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells
Zach, R.; Annis, M.; Martin-Guerrero, S. M.; Alatawi, A.; Chia, K. H.; Meredith, M.; Osborn, K.; Peter, N.; Pearce, W.; Booth, J.; Rajasekaran, M.; Dias, S.; Coleman-Evans, L.; Foster, W. R.; Harper, J. A.; Herbert, A. D.; Tighe, C.; Reuillon, T.; West, R.; Busby, O.; Burdova, K.; Crepin, D.; Ortoll, S.; Vaeteewoottacharn, K.; Dejsuphong, D.; Spencer, J.; Patel, H.; Le Grand, D.; Hunt, T. A.; Andrews, D. M.; Yamano, H.; Cutillas, P. R.; Oliver, A. W.; Ward, S. E.; Hochegger, H.
10.1101/2025.06.02.657035 — cell biology — Posted on 2025-06-03
3970 Orderly mitosis shapes interphase genome organization
Guin, K.; Keikhosravi, A.; Chari, R.; Pegoraro, G.; Misteli, T.
10.1101/2025.06.03.657645 — cell biology — Posted on 2025-06-03
3971 Lost in communication: How Mueller glia cells fail to maintain retinal integrity in USH1C retinal organoids
Wenck, N.; Zorin, M.; Wang, Q.; Kroell, S.; Hay, K.; Rickert, C.; Mendez-Lago, M.; Karunanithi, S.; Athanasiou, D.; Ziaka, K.; De Angeli, P.; Stingl, K.; Kohl, S.; Cheetham, M. E.; Mittmann, T.; Nagel-Wolfrum, K.
10.1101/2025.06.03.657614 — cell biology — Posted on 2025-06-03
3972 Pharmacological targeting of SOS1-RAS interaction triggers pancreatic β-cell proliferation and sustainably reverses diabetic hyperglycemia
Papadimitropoulou, A.; Charalampous, C.; Kogionou, P.; Reinhardt, D.; Sonntag, J.; Gavalas, A.; Hofmann, M. H.; Erlmann, P.; Franti, M.; Doerr, J.; Klein, T.; Willis, G. R.; Serafimidis, I.
10.1101/2025.06.03.657628 — cell biology — Posted on 2025-06-03
3973 Translation-specific disruption of Col1a1 expression in multiple models of Spinal Muscular Atrophy can be rescued by Risdiplam.
Sharma, G.; Paganin, M.; Huang, N.; Perenthaler, E.; Signoria, I.; Faller, K.; Maniscalco, F.; Perrucci, C.; Donzel, D.; Chaytow, H.; Basso, M.; Lauria, F.; Kothary, R.; Van Der Pol, L.; Claus, P.; Groen, E. J.; Gillingwater, T. H.; Viero, G.
10.1101/2025.06.03.657600 — molecular biology — Posted on 2025-06-03
3974 Multi-Omic Profiling Identifies Conserved Metabolic Pathways Critical for SARS-CoV-2 Variants Infection
Farley, S. E.; Kyle, J. E.; Jahn, H.; Bramer, L.; Piehowski, P.; Shepmoes, A.; Kaiser, B. L.; Williams, S. M.; Eder, J. G.; Schultz, C.; Tafesse, F.
10.1101/2025.06.02.657371 — systems biology — Posted on 2025-06-03
3975 Dietary zinc restriction induces irreversible allodynia in adult mice
Matias, D. O.; Santos, B. L. R.; Martins, A. F.; Souza, L. P.; Miranda-Alves, L.; Cardoso, L. E. M.; Miranda, A. L. P.; Lima, L. M. T.
10.1101/2025.06.02.657430 — biochemistry — Posted on 2025-06-03
3976 CTx001 for geographic atrophy: a gene therapy expressing soluble, truncated complement receptor 1 (mini-CR1)
Rathi, S.; Didangelos, A.; Pisarenka, S.; Green, R.; Emery-billcliff, P.; Patel, N.; Whalley, P.; Zamira, P.; Tilakaratna, V.; Szula, E.; Hasan, R.; Munye, M.; Unwin, R.; Bishop, P.; Keefe, D.; Clark, S. J.
10.1101/2025.06.03.657557 — biochemistry — Posted on 2025-06-03
3979 Linker Histone H1.5 Contributes to Centromere Integrity in Human Cells
Saha, A.; Bui, M.; Melters, D. P.; Ganesan, A. K.; Baek, S.; Bentahar, R. S.; Dalal, Y.
10.1101/2025.06.03.657682 — biochemistry — Posted on 2025-06-03
3981 An Antibody Cocktail-Based Immunoaffinity-LC-MS Method Enabled Ultra-Sensitive and Robust Quantification of Circulating Proinsulin Proteoforms and C-peptide
Shen, Q.; Cao, W.; Zhang, M.; Lin, T.; Shi, T.; nierves, l.; Evans-Molina, C.; Peterman, s.; boeser, c.; Sims, E. K.; Monaco, G.; QIAN, W.-J.; Qu, J.
10.1101/2025.06.02.657397 — biochemistry — Posted on 2025-06-03
3984 Structure of the energy converting methyltransferase (Mtr) of Methanosarcina mazei in complex with an oxygen-stress responsive small protein
Reif-Trauttmansdorff, T.; Herdering, E.; Bohn, S.; Pascoa, T.; Kahnt, J.; Zimmer, E.; Kumar, A.; Schmitz, R. A.; Schuller, J. M.
10.1101/2025.06.02.657420 — biochemistry — Posted on 2025-06-03
3988 Genomic factors contributing to the resilience of Salmonella enterica on ready-to-eat muskmelon
Esteban Cuesta, I.; Führer, L.; Porwollik, S.; Chu, W.; Fiddaman, S. R.; Sah, I.; McClelland, M.; Guldimann, C.
10.1101/2025.06.02.657348 — genomics — Posted on 2025-06-03
3990 An intergenerational lipid memory of the social environment in C. elegans
Wilhelm, T.; Chen, W.-W.; Wenzel, A.; Tang, W.; Cicerone, M. T.; Lehner, B.
10.1101/2025.06.03.657568 — genetics — Posted on 2025-06-03
3991 In vitro plasticity between ureteric epithelial and distal nephron identity and maturity is controlled by extracellular signals.
Kairath, P.; Er, P. X.; Wilson, S. B.; Ghobrial, I. T.; Vanslambrouck, J. M.; Chen, Y.-H.; Pruett-Miller, S. M.; Jain, S.; Little, M. H.
10.1101/2025.06.03.657609 — developmental biology — Posted on 2025-06-03
3992 Single cell multiomic analysis of the impact of Delta-9-tetrahydrocannabinol on HIV infected CD4 T cells
Ashokkumar, M.; Ge, R. Y.; Cooper-Volkheimer, A.; Margolis, D.; Li, Q.; Jiang, Y.; Murdoch, D. M.; Browne, E. P.
10.1101/2025.06.02.657468 — molecular biology — Posted on 2025-06-03
3993 Zika virus reprograms the host tRNA epitranscriptome to adapt translation to A-ending codon bias
ELDIN, P.; BERNARD, E.; VAGBO, C.; GEORGE, L.; AJIRO, M.; HAGIWARA, M.; SLUPPHAUG, G.; BRIANT, L.
10.1101/2025.06.03.657606 — microbiology — Posted on 2025-06-03
3994 A conserved glycan motif overcomes antigenic variation inducing broadly reactive antibodies against the zoonotic pathogen Streptococcus suis
Shi, Y.; Widmalm, G.; Sorieul, C.; Roodsant, T. J.; Rush, J. S.; Korotkova, N.; Jacobs, A. A. C.; Spaninks, M.; Grommen, R.; Dominguez-Medina, C. C.; Schimmel, I. M.; van der Wel, N. N.; Kenner, C. W.; Heiss, C.; Azadi, P.; Tan, L.; Codee, J. D. C.; Stegeman, A.; Schultsz, C.; Benedictus, L.; van Sorge, N. M.
10.1101/2025.06.02.656523 — microbiology — Posted on 2025-06-03
3996 Global Landscape of Human Kinase Motifs in Viral Proteomes
Alba, K.; Winters, D. M.; Makanani, S. K.; Kaushal, P.; Delgado, Y.; Ashley, I. A.; Sharma, S.; Blanc, S. F.; Kim, E.; Yaron, T.; Johnson, J. L.; Selby, J.; Hur, M.; Ni, J.; Nguyen, J.; Brent, M. H.; Yip, E.; Kassem, A.; Wohlschlegel, J.; Fregoso, O. I.; Wu, T.-T.; Li, M. M.; Bouhaddou, M.
10.1101/2025.06.02.657064 — microbiology — Posted on 2025-06-03
3997 Global proteomic analysis of Cryptococcus neoformans clinical strains reveals significant differences between latent and lethal infection
Betancourt, J. J.; McAlister, J. A.; Perez, J. M.; Meya, D. B.; Thomas, S. N.; Geddes-McAlister, J.; Nielsen, K.
10.1101/2025.06.03.657666 — microbiology — Posted on 2025-06-03
4000 The Role of SARS-CoV-2 Nucleocapsid Protein Persistence in Inducing Chronic Type I Interferon and Mitochondrial Dysfunction.
Koenig, A.; Quasem, M.; Zink, B.; Abdulla-Zoda, D.; Karunanidhi, P.; Sienko, K.; Geier, C.; Jayaraman, V.; Malik, R.; Ahmed, K.; Shanley, P. F.; Koenig, I. A.
10.1101/2025.06.02.657400 — immunology — Posted on 2025-06-03
4001 A histidine switch regulates pH-dependent filament formation by the caspase-9 CARD
Rawal, S.; Kolaric, Đesika; Bohn, S.; Kolb, D.; Pavkov-Keller, T.; Pritisanac, I.; Madl, T.; Desfosses, A.; Alderson, T. R.
10.1101/2025.06.02.657148 — biophysics — Posted on 2025-06-03
4002 Thermally activated irreversible homogenization of G-quadruplexes in an ALS/FTD-associated nucleotide expansion
Ross, D.; Lewis, O.; McLean, O.; Bhanot, S.; Donahue, S.; Baker, R.; Dias, R.; Eagerton, D.; Mohanty, V.; Mohanty, B. K.
10.1101/2025.06.02.657482 — biophysics — Posted on 2025-06-03
4005 Adhesive implant interfaces prevent fibrosis by disrupting mechanobiological feedback
Jafari, M.; Aymon, B.; Hong, Y.; Shakiba, D.; Genin, G. M.; Zhao, X.; Alisafaei, F.
10.1101/2025.06.01.657311 — biophysics — Posted on 2025-06-03
4007 Self-Assembled siRNA-Gold Supraclusters Detected at the Single-Molecule Level in the NIR-II Window
Ayed, Z.; Martin Munoz, B.; Vandekerckhove, C. I.; Faure, V.; Ali, S. N. S.; Coll, J.-L.; Cognet, L.; Le Guevel, X.
10.1101/2025.06.01.657319 — bioengineering — Posted on 2025-06-03
4012 Evolution of genotypic and phenotypic diversity in multispecies biofilms
Amador, C. I.; Moskovitz, S. Z.; Maccario, L.; Herschend, J.; Kramer, I. S.; Jeckel, H.; Cooper, V. S.; Drescher, K.; Neu, T. R.; Burmolle, M.; Roder, H. L.
10.1101/2023.10.08.561388 — microbiology — Posted on 2025-06-03
4016 NeuID, a novel neuron-specific lncRNA, resolved a key epigenetic mechanisms linking gene silencing to Alzheimer's disease
Pradhan, R.; Petrovic, Z.; Sakib, M. S.; Schroeder, S.; Krueger, D. M.; Pena, T.; Diniz, E.; Burkhardt, S.; Schuetz, A.-L.; Grz_dzielewska, I.; Toischer, K.; Stein, T. D.; Blusztajn, J. K.; Delalle, I.; Radulovic, J.; Sananbenesi, F.; Fischer, A.
10.1101/2025.06.01.657217 — neuroscience — Posted on 2025-06-03
4019 Novel mouse model reveals neurodevelopmental origin of PMM2-CDG brain pathology
Edmondson, A. C.; Budhraja, R.; Xia, Z.; Melendez-Perez, A.; Cai, C.; Radenkovic, S.; Collins, A.; Shiplett, E.; Hill, S. F.; Somarowthu, A.; Dam, J.; Pai, L.-L.; Santi, M.; Kim, S.; He, M.; Goldberg, E.; Kozicz, T.; Morava, E.; Pandey, A.; Zhou, Z.
10.1101/2025.06.01.657261 — neuroscience — Posted on 2025-06-03
4023 Evolving resistance patterns in Tetranychus urticae and Bemisia tabaci in Greece
Kampouraki, A.; Ilias, A.; Papapostolou, K.-M.; Malliaraki, S.; Pyrgianakis, I.; Karakosta, E.; Vontas, J.; Tsagkarakou, A.; Mavridis, K.
10.1101/2025.05.31.656940 — pharmacology and toxicology — Posted on 2025-06-03
4024 Lack of synergy between AR targeted therapies and PARP inhibitors in homologous recombination-proficient prostate cancer
Traphagen, N. A.; Wheeler, E.; Li, R.; Lu, F.; Ahmed, B.; Tewari, A. K.; Balk, S. P.; Nelson, P. S.; Corey, E.; Long, H.; D'Andrea, A. D.; Qiu, X.; Brown, M.
10.1101/2025.06.02.657429 — cancer biology — Posted on 2025-06-03
4025 The mutational landscape defines the proteome and spatial organization of tumor, stroma and immune cells in ovarian cancer
Dabke, K.; Gull, N.; Kreimer, S.; Peng, P.-C.; Diaz, M.; Cheikh, B. B.; Dhawan, A.; Evans, K.; Ng, N.; Yuan, X.; Rimel, B.; Li, A. J.; Karlan, B. Y.; Knott, S. V.; Gayther, S. A.; Parker, S. J.; Jones, M. R.
10.1101/2025.06.01.655822 — cancer biology — Posted on 2025-06-03
4026 Targeting HMGA1-driven leukemic transformation in myeloproliferative neoplasms with pacritinib
Yang, C.; Li, Y.; Chen, K.; Tang, X.; Zhang, Q.; Qin, W.; Fu, J.; Zeng, Y.; Ma, X.; Zheng, W.; Huang, Z.; Zhang, W.; Tang, G.; Guan, M.; Wu, Z.
10.1101/2025.06.01.657170 — cancer biology — Posted on 2025-06-03
4028 Non-Invasive Mechanical-Functional Analysis of Individual Liver Mitochondria by Atomic Force Microscopy
Zorikova, E. O.; Chourasia, S.; Rosenhek-Goldian, I.; Cohen, S. R.; Nesterov, S. V.; Gross, A.
10.1101/2025.06.01.657242 — biophysics — Posted on 2025-06-03
4033 Desmoplakin Haploinsufficiency Underlies Cell-Cell Adhesion Failure in DSP Cardiomyopathy and is Rescued by Transcriptional Activation
Smith, E. D.; Jin, K.; Ferguson, B.; Tsan, Y.-C.; DePalma, S. J.; Meisner, J. K.; Renberg, A.; Bedi, K.; Friedline, S.; Margulies, K. B.; Baker, B. M.; Helms, A. S.
10.1101/2025.06.01.657304 — genetics — Posted on 2025-06-03
4035 A method for creating custom 3D-printed molds to facilitate zebrafish imaging studies, including of cardiac development.
Miller, J. C.; Koirala, P.; Argote de la Torre, M. F.; Farsi, M.; Lieberth, J.; Shrestha, R.; Bloomekatz, J.
10.1101/2025.06.01.657246 — developmental biology — Posted on 2025-06-03
4036 prdm1a drives a fate switch between hair cells of different mechanosensory organs
Sandler, J.; Tsai, Y.-Y.; Chen, S.; Sabin, L.; Lush, M.; Sur, A.; Ellis, E.; Tran, N. T. T.; Cook, M.; Scott, A. R.; Kniss, J. S.; Farrell, J. A.; Piotrowski, T.
10.1101/2025.06.01.657251 — developmental biology — Posted on 2025-06-03
4039 Novel Adomaviruses Associated with Blotchy Bass Syndrome in Black Basses (Micropterus spp.)
Iwanowicz, L.; Raines, C.; Young, K.; Blazer, V.; Walsh, H.; Smith, G.; Holt, C.; Odenkirk, J.; Jones, T.; Hessenauer, J.-M.; Biggs, M.; Buck, C.; Greer, J.; Cornman, R. S.
10.1101/2025.06.01.657292 — microbiology — Posted on 2025-06-03
4040 ACOD1 regulates microglial arginine metabolism and inflammatory responses
Karadima, E.; Yilmaz, C.; Sinha, A.; Fodelianaki, G.; Dimothyra, S.; Nirakis, N.; Traikov, S.; Zamboni, N.; Wielockx, B.; Verginis, P.; Peitzsch, M.; Chavakis, T.; Alexaki, V. I.
10.1101/2025.06.01.657243 — immunology — Posted on 2025-06-03
4041 Diverse modes of T cell receptor sequence convergence define unique functional and cellular phenotypes
Schattgen, S.; Vegesana, K.; Hazelton, W. D.; Minervina, A.; Valkiers, S.; Slowikowski, K.; Smith, N. P.; MGH COVID-19 Team, ; Villani, A.-C.; Thomas, P. G.; Bradley, P.
10.1101/2025.05.31.657155 — immunology — Posted on 2025-06-03
4044 Direct Binding of FGFR3 Autoantibodies to Sensory Neurons Drives Hyperexcitability and Mechanical Hypersensitivity
Salih, L. Y.; Dumaire, N. L.; Vest, E.; Alkhateeb, H.; Moritz, C. P.; Tholance, Y.; Camdessanche, J.-P.; Antoine, J.-c.; Honnorat, J.; Kafaie, J.; francois-Moutal, L.; Moutal, A.
10.1101/2025.06.01.657230 — neuroscience — Posted on 2025-06-03
4046 A characterization of mouse retinal ganglion cell types labeled with AAV tools
Son, S.; Beaudoin, D. L.; Hassan, A. R.; Akpo, M. S.; Ichinose, T.; Garrett, A. M.
10.1101/2025.06.02.657062 — neuroscience — Posted on 2025-06-03
4051 Resistance to Atrial Fibrillation Domestication and Mitochondrial Dysfunction in Sheep: a potential key role of the TCA Cycle and mitochondrial redox state
Caluori, G.; Nattel, S.; Pinson, B.; Naud, P.; Beauvoit, B.; Claverol, S.; Vaillant, F.; Charron, S.; Guilloteau, F.; Loyer, V.; Constantin, M.; Popa, M.; Belykh, A.; Haeberlin, A.; Ploux, S.; Mahamat, H. A.; Dubois, R.; Guillot, B.; Krisai, P.; Kamakura, T.; Bernus, O.; Jais, P.; Dos Santos, P.; Pasdois, P.
10.1101/2025.06.01.657249 — pathology — Posted on 2025-06-03
4052 Multimodal imaging reveals a lysosomal drug reservoir that drives heterogeneous distribution of PARP inhibitors
Moncayo, C. R.; Restuadi, R.; Zhang, G.; Marks, D.; Ortega-Prieto, P.; Doherty, E.; Lambie, N.; Whilding, C.; Andrew, I.; Montoya, A.; Patel, B.; Pennycook, B. R.; Wu, V.; Takats, Z.; Matthews, N.; Young, G. R.; Shliaha, P.; Game, L.; Lenhard, B.; McNeish, I.; Fotopoulou, C.; Barr, A. R.; Cunnea, P.; Hall, Z.; Fets, L.
10.1101/2025.05.31.656628 — cancer biology — Posted on 2025-06-03
4057 Competing Subclones and Fitness Diversity Shape Tumor Evolution Across Cancer Types
Chen, H.; Shu, J.; Mudappathi, R.; Li, E.; Wang, P.; Bergsagel, L.; Yang, P.; Sun, Z.; Zhao, L.; Shi, C.; Townsend, J. P.; Maley, C.; Liu, L.
10.1101/2025.05.31.657191 — bioinformatics — Posted on 2025-06-03
4059 DeepLC introduces transfer learning for accurate LC retention time prediction and adaptation to substantially different modifications and setups
Bouwmeester, R.; Nameni, A.; Declercq, A.; Devreese, R.; Velghe, K.; Gorshkov, V.; Penanes, P. A.; Kjeldsen, F.; Rompais, M.; CARAPITO, C.; Gabriels, R.; Martens, L.
10.1101/2025.06.01.657225 — bioinformatics — Posted on 2025-06-03
4060 scVIVA: a probabilistic framework for representation of cells and their environments in spatial transcriptomics
Levy, N.; Ingelfinger, F.; Bakulin, A.; Cinnirella, G.; Boyeau, P.; Nadler, B.; Ergen, C.; Yosef, N.
10.1101/2025.06.01.657182 — bioinformatics — Posted on 2025-06-03
4061 BifurcatoR: A Framework for Revealing Clinically Actionable Signal in Variance Masquerading as Noise
Madaj, Z. B.; Ding, M.; Khoo, C. K.; Tokarski, E.; Fagnocchi, L.; PERMUTE, ; Li, Z.; Riordan, J.; Pospisilik, J. A.; Nadeau, J.; Lary, C.; Triche, T. J.
10.1101/2025.06.01.657083 — bioinformatics — Posted on 2025-06-03
4063 A Set of Novel Far-Red Fluorescent Proteins for Temporal Domain Multiplexing and Super-Resolution Imaging
Olumayowa, F.; Rong, Z.; Wang, R.; Papadaki, S.; Wang, X.; Cao, J.; Subach, F. V.; Koster, R. W.; Namikawa, K.; Piatkevich, K. D.
10.1101/2025.06.01.657196 — biochemistry — Posted on 2025-06-03
4066 A Single-cell and Spatially Resolved Cell Atlas of Human Esophageal Squamous Cell Carcinoma
shi, y.; An, K.; Qi, Y.; Zhang, X.; Wang, Y.; Zhang, X.; Zhou, S.; Li, O.; Zhou, J.; Du, Y.; Hou, M.; Yang, Y.-G.; Kan, Q.; Tian, X.
10.1101/2025.06.01.657221 — genomics — Posted on 2025-06-03
4068 Simulation-based spatially explicit close-kin mark-recapture
Patterson, G.; Goodfellow, C. K.; Ting, N.; Kern, A. D.; Ralph, P. L.
10.1101/2025.05.31.656892 — ecology — Posted on 2025-06-03
4069 Transcription factors SP5 and SP8 drive primary cilia formation
Liang, Y.; Koche, R.; Chalamalasetty, R. B.; Stephen, D. N.; Kennedy, M. W.; Lao, Z.; Pang, Y.; Kuo, Y.-Y.; Lee, M.; Lobo, F. P.; Huang, X.; Hadjantonakis, A.-K.; Yamaguchi, T. P.; Anderson, K. V.; Joyner, A. L.
10.1101/2025.06.03.657415 — developmental biology — Posted on 2025-06-03
4072 Structural basis of liver de-targeting and neuronal tropism of CNS-targeted AAV capsids
Brittain, T. J.; Jang, S.; Coughlin, G. M.; Barcelona, B. H.; Giriat, I.; Ristic, F.; Appling, N.; Chossis, C. P.; Shay, T. F.; Gradinaru, V.
10.1101/2025.06.02.655683 — molecular biology — Posted on 2025-06-03
4073 Mobile genetic elements that shape microbial diversity and functions in thawing permafrost soils
Guo, J.; Aroney, S.; Dominguez-Huerta, G.; Smith, D.; Vik, D.; Ansah, C. O.; Pratama, A. A.; Solonenko, S.; Tian, F.; Howard-Varona, C.; Zhong, Z.; Fofana, A.; Smith, G.; Hodgkins, S. B.; Cronin, D.; EMERGE Field Teams 2010-2019, ; EMERGE Coordinators, ; Woodcroft, B. J.; Tyson, G. W.; Rich, V. I.; Sullivan, M. B.; Roux, S.; Bagby, S. C.
10.1101/2025.02.12.637893 — microbiology — Posted on 2025-06-03
4074 Evaluating Best Practices for Isolating Pyrophilous Bacteria and Fungi from Burned Soil
Enright, D. J.; Veerabahu, A.; Quaal, R. J.; Vega, M.; Nguyen, A.; Grindeland, J.; Randolph, J. W. J.; Ordonez, M. E.; Glassman, S. I.
10.1101/2024.09.16.612975 — microbiology — Posted on 2025-06-03
4075 Non-Physiological Potassium Concentrations in Commercial Culture Media Trigger Acute Epileptiform Activity in Human iPSC-Derived Neurons
Lyckenvik, T.; Izsak, J.; Arthursson, E.; Forsberg, M.; Johansson, K.; Zetterberg, H.; Axelsson, M.; Wasling, P.; Theiss, S.; Hanse, E.; Illes, S.
10.1101/2025.05.31.657142 — neuroscience — Posted on 2025-06-03
4076 Social experience alters behaviors by reprogramming the Fruitless pathway and circadian state in Drosophila
Du, C.; Okuwa, S.; Jia, L.; Rozados Barreiro, M.; Scott, S.; Sotelo Fonseca, J. E.; Mabuchi, Y.; Appadoo, S.; Garcia, L.; Rohrbach, S.; Koruk, S.; Balkanli, E.; Lin, J.; Yapici, N.; Jones, C.; Volkan, P.
10.1101/2025.05.30.657129 — neuroscience — Posted on 2025-06-03
4078 Antidepressants reactivate developmental plasticity through remodeling of extracellular matrix
Nguyen, P. T.; Sun, E.; Shi, Y.; Tamura, S.; Xiao, Y.; Lacefield, C.; Turi, G.; Hen, R.
10.1101/2025.01.03.631260 — neuroscience — Posted on 2025-06-03
4080 Sleep loss suppresses the motivation to prepare for sleep
Freitag, N.; El-Tawil, K.; Crane, A.; Hilo, V.; Saad, G.; Eban-Rothschild, A.
10.1101/2025.06.02.657276 — neuroscience — Posted on 2025-06-03
4082 Molecular Subtyping Based on Hippocampal Cryptic Exon Burden Reveals Proteome-wide Changes Associated with TDP-43 Pathology across the Spectrum of LATE and Alzheimer's Disease
Trautwig, A. N.; Shantaraman, A.; Chung, M.; Dammer, E. B.; Ping, L.; Duong, D. M.; Petrucelli, L.; Ward, M. E.; Glass, J. D.; Nelson, P. T.; Levey, A. I.; McEachin, Z. T.; Seyfried, N. T.
10.1101/2025.05.30.656396 — neuroscience — Posted on 2025-06-03
4085 A Solid-Phase Extraction Capture (SPEC) workflow in nanoliter volumes for fast, robust and ultrasensitive proteomics
Heymann, T.; Oliinyk, D.; Henneberg, L.; Rodriguez, E.; Bardziukova, A.; Oeller, M.; Murgia, M.; Olsen, J. V.; Stoychev, S.; Bache, N.; Mann, M.
10.1101/2025.05.31.657165 — systems biology — Posted on 2025-06-03
4086 Expanding salivary biomarker detection by creating a synthetic neuraminic acid sensor via chimeragenesis
Verzino, S. J.; Priyev, S. A.; Sanchez Estrada, V. A.; GholamianMoghaddam, A.; Crowley, G. X.; Rutkowski, A.; Lam, A. C.; Nazginov, E. S.; Kotemelo, P.; Bacelo, A.; Flannery, J. D.; Gavrilov, K.; Sukhram, D. T.; Vazquez, F. X.; Fernandez Juarez, J.
10.1101/2024.06.13.598939 — synthetic biology — Posted on 2025-06-03
4089 Oxidative stress mediates cardiac electrophysiological injury in inhalation exposure to flavored vaping products.
Abou-Assali, O. J.; Reiser, M.; Chang, M.; Chidipi, B.; Asswaytte, R.; Zhang, Y.; Szekeres, C.; Calcul, L.; Noujaim, S. F.
10.1101/2025.05.31.657128 — physiology — Posted on 2025-06-03
4090 Cryo-EM structure of DNA-unbound human MCM2-7 complex reveals new disease-relevant regulation
Liu, Y.; Yang, M.; Lu, P.; Gao, H.; He, M.; Wang, Y.; Qi, A.; Cao, T.; Zhang, Q.; Qi, S.; Shi, Y.; Yu, H.
10.1101/2025.05.31.656953 — biophysics — Posted on 2025-06-03
4093 A parallelly distributed microscope and software system for scalable high-throughput multispectral 3D imaging
Jiang, H.; Walker, L. A.; Li, Y.; Duan, B.; Niu, X.; Hsieh, J.-C.; Cheng, M.-C.; Su, H.; Sheng, K.; Tang, J. P.; Athukorala, K.; Greene, S.; Pan, R.; Parlapalli, A.; Yin, P.; Cui, M.; Cai, D.
10.1101/2025.05.31.657163 — bioengineering — Posted on 2025-06-03
4098 Clonal Expansion of Alveolar Fibroblast Progeny Drives Pulmonary Fibrosis
Molina, C.; Tsukui, T.; Khan, I.; Ren, X.; Qiu, W.; Matthay, M.; Wolters, P.; Sheppard, D.
10.1101/2025.05.31.657194 — cell biology — Posted on 2025-06-03
4099 Sequence grammar and dynamics of subcellular translation revealed by APEX-Ribo-Seq
Tomuro, K.; Akaiwa, T.; Harada, A.; Kobayashi, K.; Shiina, N.; Kawaguchi, K.; Shichino, Y.; Iwasaki, S.
10.1101/2025.05.26.656194 — molecular biology — Posted on 2025-06-03
4104 Modelling Glomerular Filtration using Multispectral Optoacoustic Tomography and a Novel Near-infrared Dye
Littlewood, J.; Harwood, R.; Vajpayee, S.; Perciaccante, R.; Trivino-Cepeda, K.; Sharkey, J.; Sardella, T.; Burton, N.; Taylor, A.; Wilm, B.; Bearon, R.; Murray, P.
10.1101/2025.05.31.657147 — physiology — Posted on 2025-06-03
4105 Introduction of cytosine-5 DNA methylation sensitizes cells to oxidative damage
Krwawicz, J.; Sheeba, C. J.; Hains, K.; McMahon, T.; Zhang, Y.; Kriaucionis, S.; Sarkies, P.
10.1101/2024.09.13.612259 — molecular biology — Posted on 2025-06-03
4106 Heat-off responses of epidermal cells sensitize Drosophila larvae to noxious inputs
Yoshino, J.; Chiu, A.; Morita, T.; Yin, C.; Tenedini, F. M.; Sokabe, T.; Emoto, K.; Parrish, J. Z.
10.1101/2025.05.30.656957 — neuroscience — Posted on 2025-06-03
4107 A covalent recognition strategy enables conspecific mate identification
Jang, S. S.; Mandala, S.; Jiang, H.; Zhang, X.; Cole, P. A.; del Marmol, J. I.
10.1101/2025.05.30.657074 — neuroscience — Posted on 2025-06-03
4108 Transforming descending input into motor output: An analysis of the Drosophila Male Adult Nerve Cord connectome
Cheong, H. S. J.; Eichler, K.; Stuerner, T.; Asinof, S. K.; Champion, A. S.; Marin, E. C.; Oram, T. B.; Sumathipala, M.; Venkatasubramanian, L.; Namiki, S.; Siwanowicz, I.; Costa, M.; Berg, S.; Janelia FlyEM Project Team, ; Jefferis, G. S. X. E.; Card, G. M.
10.1101/2023.06.07.543976 — neuroscience — Posted on 2025-06-03
4110 Reflected Inline Detection in Epi Oblique Plane Microscopy
Prince, M. N. H.; Muthubharathi, B. C.; Herath, W.; Sain, N.; Rupam, M. R. I.; Bhat, A. Q.; Wani, A. R.; Syed, M. H.; Kim, T.-H.; Walker, M. C.; Ponomarova, O.; Chakraborty, T.
10.1101/2025.05.30.657110 — biophysics — Posted on 2025-06-03
4112 Risk evaluation of newly emerging flu viruses based on genomic sequences and AI
Li, H.; Feng, Y.; Lu, C.; Fu, P.; Wang, X.; Yang, L.; Shu, Y.; Jiang, T.; Wang, D.; Peng, Y.
10.1101/2025.04.18.649608 — bioinformatics — Posted on 2025-06-03
4113 Species interactions determine plasmid persistence in a 3-member bacterial community
Schaal, K. A.; Wang, Y.-J.; Nauta, J.; Pilosof, S. A.; De Domenico, M.; Hall, J. P.
10.1101/2025.05.31.657151 — ecology — Posted on 2025-06-03
4114 Two birds with one stone: a novel potential antibiotic blocking IsdB-mediated heme extraction by Staphylococcus aureus with serendipitous hemoglobin left-shifting activity
Hijazi, S.; Marchesani, F.; Marchetti, M.; Buoli Comani, V.; Brear, P.; Campanini, B.; Ronda, L.; Faggiano, S.; Gianquinto, E.; Asgharpour Hassankiadeh, S.; Rolando, B.; Spyrakis, F.; Compari, C.; Lazzarato, L.; De Bei, O.; Frangipani, E.; Bettati, S.
10.1101/2025.05.29.656759 — microbiology — Posted on 2025-06-03
4116 Multivariate pattern analysis reveals resting-state EEG biomarkers in fibromyalgia
Soldic, D.; Martin-Buro, M. C.; Lopez-Garcia, D.; del Pino, A. B.; Fernandes-Magalhaes, R.; Ferrera, D.; Pelaez, I.; Mercado Romero, F.
10.1101/2025.05.30.657056 — neuroscience — Posted on 2025-06-03
4117 Normalization of Prefrontal Network Dynamics Prevents Cognitive Impairments After Developmental Insult
Khalife, M. R.; Jasinski, P.; Abed Rabbo, K.; Ouardouz, M.; Mahoney, J. M.; Scott, R.; Hernan, A.
10.1101/2025.05.30.657069 — neuroscience — Posted on 2025-06-03
4118 Detection of astrocyte epigenetic memory in in vitro systems, experimental autoimmune encephalomyelitis and multiple sclerosis samples
Quintana, F. J.; Li, Z.; Faust Akl, C.; Lee, J.-H.; Piester, G.; Antel, J.; Rothhammer, V.; Wheeler, M. A.; Prat, A.; Clark, I. C.
10.1101/2025.05.30.657119 — neuroscience — Posted on 2025-06-03
4119 Bright and Photostable Voltage Sensors Derived from mBaoJin
Zhang, H.; Zhou, S.; Kuzmicheva, T. P.; Subach, O. M.; Grimm, C.; Eom, M.; Baror-Sebban, S.; Adam, Y.; Yoon, Y.-G.; Emilliani, V.; Subach, F. V.; Piatkevich, K. D.
10.1101/2025.05.30.657123 — neuroscience — Posted on 2025-06-03
4120 Structural and Mechanistic Insights into Symmetry Conversion in Plant GORK K+ Channel Regulation
Li, Q.-y.; Qin, L.; Tang, L.-h.; Zhang, C.-r.; Huang, S.; Wang, K.; Zhang, G.-h.; Hao, N.-j.; Xiao, Q.; Niu, T.-X.; Su, M.; Hedrich, R.; Chen, Y.-h.
10.1101/2024.12.17.628833 — plant biology — Posted on 2025-06-03
4123 Adaptive motility enables neutrophils to rapidly navigate confined capillaries
Deygas, M.; Bernard, M.; Nivoit, P.; Barbier, L.; Wang, L.; Maurin, M.; Tejerina, E.; Jakuszeit, T.; Deslys, A.; Garcia-Gomez, M.; Baaziz, O.; Garbay, S.; Terriac, E.; Attia, R.; Dumenil, G.; Piel, M.; VARGAS, P.
10.1101/2025.01.08.631737 — cell biology — Posted on 2025-06-03
4124 Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model
Piatti, L.; Batzilla, A.; Nakaki, F.; Fleckenstein, H.; Korbmacher, F.; Long, R. K. M.; Schraivogel, D.; Hawkins, J. A.; Romero-Urunuela, T.; Lopez-Gutierrez, B.; Sanz, S.; Schwab, Y.; Steinmetz, L. M.; Sharpe, J.; Bernabeu, M.
10.1101/2024.10.15.618439 — microbiology — Posted on 2025-06-03
4127 Hematobiochemical Alterations and Pathological Lesions Induced by Fasciolosis in Slaughtered Cattle at Gondar ELFORA Abattoir, Ethiopia
Temesgen, A. B.; Mitiku, T.; Birhan, M.; Kebede, M. C.; Yesuf, M.; Mekonnen, M. Y.; Alemayehu, M. M.; Malede, B. A.; Geda, A. M.; Tumebo, A. W.; Shiferaw, K. A.; Wassie, Z. G.; Berie, G. K.; Mengistu, B. A.; Feleke, M. G.; Edenshaw, F.; Yitie, M. T.; Kasse, G. E.; Tsehay, E. M.; Shiferaw, S. A.
10.1101/2024.08.10.607441 — pathology — Posted on 2025-06-03
4128 Kinesin-1 Autoinhibition Tunes Cargo Transport by Motor Ensembles
Bensel, B. M.; Previs, S. B.; Fagnant, P. M.; Trybus, K. M.; Walcott, S.; Warshaw, D. M.
10.1101/2025.05.06.652443 — biophysics — Posted on 2025-06-03
4130 DeepPGDB: A Novel Paradigm for AI-Guided Interactive Plant Genomic Database
Li, F.; Chen, J.; Luo, W.; Liu, J.; Hou, Z.; Gan, Z.; Zhan, P.; Wang, Z.; Hu, H.; Chen, G.; Shuai, B.; Zhao, H.; Bi, C.; Wang, S.
10.1101/2025.06.01.657209 — bioinformatics — Posted on 2025-06-03
4131 OPM quantum sensors enhance non-invasive neuroimaging performance
Brickwedde, M.; Anders, P.; Krueger, P.; Sander, T.; Uhlhaas, P.
10.1101/2025.05.30.657044 — neuroscience — Posted on 2025-06-03
4134 The Regulation of COX-2, ABCA1 and ABCG1 by the lncRNA PACERR links the inflammatory response and cholesterol homeostasis
Hennessy, E. J.; Tanosaki, T.; Lordan, R. J.; Tang, S. Y.; Shuvaev, V.; Ghosh, S.; Das, U.; Joshi, R.; Meng, H.; Snouwaert, J. n.; Winter, H.; Maegdefessel, L.; Koller, B. N.; FitzGerald, G. A.
10.1101/2025.06.02.657432 — cell biology — Posted on 2025-06-03
4135 Regulation of reticular adhesions by KANK2 and talin2 in two melanoma cell lines
Rac, A.; Loncaric, M.; Stojanovic, N.; Fatima, M.; Resetar, M.; Hrsak, D.; Humphries, J. D.; Humphries, M. J.; Ambriovic-Ristov, A.
10.1101/2025.06.02.657402 — cell biology — Posted on 2025-06-03
4136 Chlamydial membrane vesicles deliver the chlamydial porin OmpA to mitochondria to inhibit apoptosis
Mesesan, A.; Oehler, H.; Kontchou, C. W.; Haimovici, A.; Helmstädter, M.; Kretz, O.; Schilling, O.; Nazarenko, I.; Matti, U.; Ries, J.; Gentle, I.; Häcker, G.
10.1101/2025.06.02.657351 — cell biology — Posted on 2025-06-03
4141 Assessing plant phenological changes based on drivers of spring phenology
Jiang, Y.; Mayor, S.; Chu, X.; Ye, X.; Man, R.; Tao, J.; Dang, Q.-L.
10.1101/2025.04.13.648654 — ecology — Posted on 2025-06-03
4142 A minimal hybridization capture system for the parallel enrichment and cost-effective detection of ancient human pathogens
Kocher, A.; Seguin-Orlando, A.; Clavel, P.; Louvel, G.; Jonvel, R.; Tzortzis, S.; Signoli, M.; Costedoat, C.; Orlando, L.
10.1101/2025.06.02.657376 — molecular biology — Posted on 2025-06-03
4144 Single-cell spatial map of cis-regulatory elements for disease-related genes in the macaque cortex
Meng, J.; Lei, Y.; Chen, C.; Zhu, Z.; Sun, Y.; Huang, Y.; Hu, K.; Bai, Y.; Fei, T.; Liu, Z.; Li, C.; Shen, Z.; Liu, L.; Li, C.; Song, T.; Liu, C.; Poo, M.; Liu, S.; Sun, Y.
10.1101/2025.06.03.657577 — neuroscience — Posted on 2025-06-03
4145 Visual processing of manipulable objects in the ventral stream is modulated by inputs from parietal action systems
Garcea, F. E.; Strawderman, E.; Burns, W.; Cotroneo, M.; Meyers, S. P.; Schmidt, T.; Walter, K. A.; Pilcher, W. H.; Mahon, B. Z.
10.1101/2025.06.01.657280 — neuroscience — Posted on 2025-06-03
4146 Cysteine signaling in plant pathogen response
Moormann, J.; Heinemann, B.; Angermann, C.; Koprivova, A.; Armbruster, U.; Kopriva, S.; Hildebrandt, T. M.
10.1101/2025.03.13.642987 — plant biology — Posted on 2025-06-03
4147 Action mechanism of a novel agrichemical quinofumelin against Fusarium graminearum
Xiu, Q.; Yin, X.; Chen, Y.; Zhang, Z.; Mao, Y.; Wang, T.; Zhang, J.; Zhou, M.; Duan, Y.
10.1101/2025.01.13.632717 — pathology — Posted on 2025-06-03
4148 Structures of protein folding intermediates on the ribosome
Chan, S. H. S.; Streit, J. O.; Wlodarski, T.; Mitropoulou, A. N.; Cassaignau, A. M. E.; Bukvin, I. V.; Cabrita, L. D.; Christodoulou, J.
10.1101/2025.04.07.647236 — biophysics — Posted on 2025-06-03
4149 EASYstrata: An All-in-One Workflow for Genome Annotation and Genomic Divergence Analysis
Rougemont, Q.; Lucotte, E.; Boyer, L.; Jalaber, A.; Snirc, A.; Giraud, T.; Rodriguez de la Vega, R. C.
10.1101/2025.01.06.631483 — genomics — Posted on 2025-06-03
4150 Use of massive DNA barcoding to monitor biodiversity: a test on forest soil macrofauna
Jabot, F.; Auger, G. B.; Bonnal, P.; Pizaine, M.; Roncoroni, M.; Revaillot, S.; Pottier, J.
10.1101/2025.02.07.636998 — ecology — Posted on 2025-06-03
4151 Dynamical forces drive cell and organ morphology changes during embryonic development
Manna, R. K.; Retzlaff, E. M.; Hinman, A. M.; Lan, Y.; Abdel-Razek, O.; Bates, M.; Hehnly, H.; Amack, J. D.; Manning, M. L.
10.1101/2024.07.13.603371 — developmental biology — Posted on 2025-06-03
4152 Phylogenetic position and mitochondrial genome evolution of 'orphan' eukaryotic lineages
Zlatogursky, V.; Boscaro, V.; Lax, G.; Wanntorp, M.; Pohl, N.; Burki, F.; Keeling, P. J.
10.1101/2025.04.16.649146 — microbiology — Posted on 2025-06-03
4154 Targeting Neutrophil Extracellular Traps to inhibit Colon Cancer Tumor Necrosis and Metastasis
Gazzara, E.; Adrover, J. M.; Lui, A.; Han, S.; Aminzada, Z.; Bhandari, N.; Sivetz, N.; Shirue, V. S.; Shergill, B. S.; Curtis, M. B.; George, S. C.; Cicala, A.; Rishi, A.; Chung, C.; Devoe, C.; Huang, H.; Weiss, M.; Lou, E.; Tuveson, D. A.; Beyaz, S.; Westcott, P. M. K.; Egeblad, M.; Gholami, S.
10.1101/2025.05.30.657122 — cancer biology — Posted on 2025-06-03
4155 A missense mutation in Muc2 promotes gut microbiome- and metabolome-dependent colitis-associated tumorigenesis.
Verna, G.; De Santis, S.; Islam, B.; Sommella, E. M.; Licastro, D.; Zhang, L.; De Almeida Celio, F.; Merciai, F.; Caponigro, V.; Campiglia, P.; Pizarro, T. T.; Chieppa, M.; Cominelli, F.
10.1101/2025.05.31.657160 — cancer biology — Posted on 2025-06-03
4156 Klf4-dependent pivotal role of smooth muscle-derived Gli1+ lineage progenitor cells in lung cancer progression
Lu, S.; Navarro, A. C.; Johnson, A. M.; Noble, T.; Jolly, A. J.; Moulton, K. S.; Nemenoff, R. A.; Weiser-Evans, M. C.
10.1101/2025.05.30.657094 — cancer biology — Posted on 2025-06-03
4157 KOLF2.1J iTF-Microglia: A standardized platform to studymicroglial transcriptional regulatory networks in CNS disease
Rodriguez-Nunez, I.; Bartley, S. C.; Taylor, J. W.; Johnston, S. Q.; Rogers, B. B.; Meadows, S. K.; Newberry, K. M.; Cochran, J. N.; Myers, R. M.
10.1101/2025.05.30.657077 — genomics — Posted on 2025-06-03
4160 WNK1 kinase activity is required for maintenance of podocyte structure
Liu, Z.; Lee, E.; Jiang, S.; Yoon, J.; Ahmed, F.; Rahman, M. A.; Bleicher, W. P.; Suleiman, H. Y.; Bruggeman, L. A.; Miller, R. T.; Chang, A. N.
10.1101/2025.05.30.657136 — cell biology — Posted on 2025-06-03
4161 Spatial Heterogeneity of Macrophages in the Human Lung
Hume, P. S.; Lyn-Kew, K. H.; Wynn, E. A.; Steinhart, B.; Driscoll, J.; Jacobson, S.; Henson, P. M.; Mould, K. J.; Moore, C. M.; Janssen, W. J.
10.1101/2025.05.30.657106 — immunology — Posted on 2025-06-03
4163 VGLL3-centered network connects placental, vascular, and immune defects in preeclampsia
Plazyo, O.; Chopp, L. B.; Peela, R.; Young, K.; Zhang, H.; Bogle, R.; Hesson, A.; Langen, E.; Bergin, I. L.; Syu, L.-J.; Erba, J.; Kirma, J.; Dey, P.; Zhang, L.; Sarkar, M. K.; Swindell, W. R.; Gallagher, K. A.; Ward, N. L.; Singer, K.; Kahlenberg, J. M.; Billi, A. C.; Dlugosz, A. A.; Ganesh, S. K.; Tsoi, L. C.; Gudjonsson, J. E.
10.1101/2025.05.30.657097 — immunology — Posted on 2025-06-03
4166 DNA-based delivery of incretin receptor agonists using MYO Technology leads to durable weight loss in a diet-induced obesity model
Sasset, L.; Cameron, A. D.; Sussman, C.; Rubinelli, L.; Maji, D.; Miller, R.; Thompson, A. T.; Campbell, D.; Walker, M. R.; Drozdz, M. M.; Liberatore, R. A.
10.1101/2025.05.30.656889 — physiology — Posted on 2025-06-03
4168 A network medicine framework for multi-modal data integration in therapeutic target discovery
Baltusyte, G.; Toleman, I.; Jones, J.; Welsh, S. J.; Stewart, G. D.; Mitchell, T. J.; Saeb-Parsy, K.; Han, N.
10.1101/2025.05.29.656813 — bioinformatics — Posted on 2025-06-03
4173 Turbulence orchestrates actin-mitochondria dynamics to preserve GPIbα and support iPSC-derived platelet biogenesis
Nakamura, E.; Harada, Y.; Nakamura, S.; Fujio, K.; De Wispelaere, K.; Thys, C.; Freson, K.; Yamamoto, T.; Sawaguchi, A.; Suetsugu, S.; Eto, K.
10.1101/2025.05.22.655481 — cell biology — Posted on 2025-06-03
4174 Circular RNAs accumulate in ageing human placental tissue and in stillbirth, leading to DNA damage and cellular senescence
Arthurs, A. L.; Jackson, M. R.; McCullough, D.; SCOTT, H.; Barnett, C. P.; Webb, S. T.; Smith, M. D.; Jankovic-Karasoulos, T.; Dekker, G. A.; Roberts, C. T.
10.1101/2024.09.02.610398 — molecular biology — Posted on 2025-06-03
4176 Recurrent Emergence of Boundary Cell Types During Evolution of Floral Bullseye Patterns
Oud, S.; Zurowski, M. M.; van der Jagt, P. L.; Yeo, M. T. S.; Walker, J. F.; Moyroud, E.; Vroomans, R. M. A.
10.1101/2025.05.03.651954 — systems biology — Posted on 2025-06-03
4177 The signature of reproduction on wood anatomy in European beech reveals potential for masting reconstruction
Resente, G.; Crivellaro, A.; Fleurot, E.; Piermattei, A.; Maimone, F.; Wilmking, M.; Hacket-Pain, A.; Motta, R.; Ascoli, D.
10.1101/2025.05.27.656364 — plant biology — Posted on 2025-06-03
4179 Enabling Plasmid-based Expression in Clostridium kluyveri using a Biparental Methylation-Conjugation System
Agena, E. M.; Badani, A. A.; Lindner, B. G.; Gois, I. M.; Dempster, A. W.; Minton, N. P.; Mahadevan, R.; Lawson, C. E.
10.1101/2025.05.30.657078 — bioengineering — Posted on 2025-06-03
4182 Increased Genetic Protection Against Alzheimer's Disease in Centenarians
Bae, H.; Song, Z.; Ali, A.; Sasaki, T.; Tesi, N.; Lords, H.; Leshchyk, A.; Abe, Y.; Hirose, N.; Arai, Y.; Barzilai, N.; Weiss, E. F.; Hulsman, M.; van der Lee, S. J.; van Schoor, N. M.; Huisman, M.; Pijnenburg, Y. A. L.; van der Flier, W. M.; Reinders, M.; Holstege, H.; Milman, S.; Perls, T.; Andersen, S. L.; Sebastiani, P.
10.1101/2025.06.02.657442 — genetics — Posted on 2025-06-03
4183 Composition variations in archaeological human bone proteomes
Asmundsdottir, R. D.; Troche, G.; Olsen, J. V.; Schrader, S.; Welker, F.
10.1101/2025.06.02.657369 — evolutionary biology — Posted on 2025-06-03
4184 Purinergic receptor activation rectifies autism-associated endothelial dysfunction
Ouellette, J.; Warsi, S.; Romero, P.; Khare, P.; Naz, S.; Aubert-Tandon, L.; Pileggi, C.; Yandiev, S.; Freitas-Andrade, M.; Comin, C. H.; Harper, M.-E.; Manickam, D. S.; Dabertrand, F.; Saghatelyan, A.; Lacoste, B.
10.1101/2025.06.02.657522 — cell biology — Posted on 2025-06-03
4191 Aberrant cerebrovascular reactivity presents as an early biomarker of psychosis susceptibility in patients with 22q11.2DS
Delavari, F.; Moia, S.; Forrer, S.; Sandini, C.; Kojovic, N.; Pascucci, A.; Lacour, C.; Eliez, S.; Van De Ville, D.
10.1101/2025.06.02.657392 — neuroscience — Posted on 2025-06-03
4192 Autism-associated SCN2A deficiency disrupts cortico-striatal circuitry in human brain assembloids
Chen, X.; Zhang, J.; Wu, J.; Robinson, M. J.; Kothandaraman, H.; Yoo, Y.-E.; Dopeso-Reyes, I. M. G.; Buffenoir, T. D.; Halurkar, M. S.; Zhang, Z.; Wang, M.; Creager, E. N.; Zhao, Y.; Olivero-Acosta, M. I.; Wettschurack, K. W.; Que, Z.; Yuan, C.; Schaser, A. J.; Lanman, N. A.; Rochet, J.-C.; Skarnes, W. C.; Kremer, E. J.; Yang, Y.
10.1101/2025.06.02.657036 — neuroscience — Posted on 2025-06-03
4195 Multimodal Validation of the Existence of Transitional Cerebellar Progenitors in the Human Fetal Cerebellum
Luo, Z.; Xia, M.; Zhang, F.; Xin, D.; Rao, R.; Kiang, K.; Berry, K.; Xiong, Y.; Liu, H.; Lin, Y.; Hu, M.; Xin, M.; Ma, J.; Li, H.; Taylor, M. D.; Zhou, W.; Lu, Q. R.
10.1101/2025.06.01.657310 — developmental biology — Posted on 2025-06-03
4196 An applicable and efficient retrograde monosynaptic circuit mapping tool for larval zebrafish
Chen, T.; Deng, Q.; Lin, K.; Zheng, X.; Wang, X.; Zhong, Y.; Ning, X.; Li, Y.; Xu, F.; Du, J.; Du, X.
10.1101/2024.06.27.601104 — neuroscience — Posted on 2025-06-02
4198 Evaluation of a prototype Orbitrap Astral Zoom mass spectrometer for quantitative proteomics - Beyond identification lists
Hsu, C.; Shulman, N.; Stewart, H.; Petzoldt, J.; Pashkova, A.; Plubell, D.; Denisov, E.; Hagedorn, B.; Damoc, E.; MacLean, B. X.; Remes, P. M.; Canterbury, J. D.; Makarov, A.; Hock, C.; Zabrouskov, V.; Wu, C. C.; MacCoss, M. J.
10.1101/2025.05.30.657132 — biochemistry — Posted on 2025-06-02
4201 Alpha and Beta Oscillations Mediate the Effect of Motivation on Neural Coding of Cognitive Flexibility
Delgado, J. M. C.; Ison, M. J.; Muhle-Karbe, P. S.; Stokes, M. G.; Hall-McMaster, S.; Myers, N. E.
10.1101/2025.03.11.642697 — neuroscience — Posted on 2025-06-02
4202 In vivo deep-brain microscopy at submicrometer resolution with refractive index-matched prism interfaces
Takahashi, T.; Zhou, Y.; Tsutsumi, M.; Ito, C.; Hatakeyama, A.; Ishii, H.; Saitoh, A.; Yukawa, H.; Nabekura, J.; Nemoto, T.; Otomo, K.; Matsuhisa, N.; Agetsuma, M.
10.1101/2025.05.30.657010 — neuroscience — Posted on 2025-06-02
4203 Quantum Cognition Machine Learning for Forecasting Chromosomal Instability
Di Caro, G.; Kirakosyan, V.; Abanov, A. G.; Candelori, L.; Hartmann, N.; Lam, E. T.; Musaelian, K.; Samson, R.; Villani, D.; Wells, M. T.; Wenstrup, R. J.; Xu, M.
10.1101/2025.05.30.656882 — cancer biology — Posted on 2025-06-02
4204 Biomni: A General-Purpose Biomedical AI Agent
Huang, K.; Zhang, S.; Wang, H.; Qu, Y.; Lu, Y.; Roohani, Y.; Li, R.; Qiu, L.; Zhang, J.; Di, Y.; Marwaha, S.; Carter, J.; Zhou, X.; Wheeler, M. T.; Bernstein, J.; Wang, M.; He, P.; Zhou, J.; Snyder, M.; Cong, L.; Regev, A.; Leskovec, J.
10.1101/2025.05.30.656746 — bioinformatics — Posted on 2025-06-02
4210 Venus-MAXWELL: Efficient Learning of Protein-Mutation Stability Landscapes using Protein Language Models
Yu, Y.; Jiang, F.; Ma, X.; Zhang, L.; Zhong, B.; Ouyang, W.; Fan, G.; Yu, H.; Hong, L.; Li, M.
10.1101/2025.05.30.656964 — bioinformatics — Posted on 2025-06-02
4213 Sex specific correction of maternal inflammation-induced behavioral abnormalities by the inhibition of colony-stimulating factor 1 receptor
Delpech, J. C.; Yeh, H.; Kalavai, S. V.; You, Y.; Ruan, Z.; Touch, N.; Hersh, S.; Monguillon, P.; Johnson, W. E.; Rau, A.; Madore-Delpech, C.; Ikezu, T.; Ikezu, S.
10.1101/2025.05.30.657085 — animal behavior and cognition — Posted on 2025-06-02
4217 Must epidemiologically impactful vector control interventions disrupt mosquito population structure? A case study of a cluster-randomised controlled trial.
Dennis, T. P. W.; Guelbeogo, W. M.; Ferguson, H. M.; Lindsay, S.; N'Fale, S.; Pignatell, P.; Ranson, H.; Sanou, A.; Tiono, A.; Weetman, D.; Viana, M.
10.1101/2025.04.16.649034 — ecology — Posted on 2025-06-02
4218 piRNAs are abundant in the early embryo of the crustacean Parhyale hawaiensis
Calvo Gonzalez, L.; Pettini, T.; Ylla, G.; Ronshaugen, M. R.; Griffiths-Jones, S.
10.1101/2025.05.30.656998 — developmental biology — Posted on 2025-06-02
4219 Engineering a mouse-adapted SADS-CoV and establishing a neonatal mouse model to study its infection
Zhang, H.; Zhou, J.; Li, P.; Zhang, M.; Jing, R.; Zhu, H.; Lang, Y.; He, Q.; Zhang, M.; Li, W.
10.1101/2025.06.02.657353 — microbiology — Posted on 2025-06-02
4220 Genome-wide CRISPR/Cas9 knockout screen identifies host factors essential for Bovine Parainfluenza Virus Type 3 replication
Hao, J.; Gao, X.; Light, C.; Sun, Y.; Lu, S.; Tian, Y.; Gao, X.; Su, Y.; Gao, J.; Huang, X.; Wang, J.; Zhang, Q.; Hai, R.; Hu, W.; Wang, G.
10.1101/2025.06.02.657355 — microbiology — Posted on 2025-06-02
4221 HLA-DQ monomer-based enrichment of alloreactive CD4 T cells
Zhanzak, Z.; Cina, D.; Zhang, X.; Hadley, A.; Kissick, H.; Larsen, C.
10.1101/2025.05.30.656890 — immunology — Posted on 2025-06-02
4222 Multi-Stable Bimodal Perceptual Coding within the Ventral Premotor Cortex
Andrade-Ortega, B.; Diaz, H.; Bayones, L.; Alvarez, M.; Zainos, A.; Rivera-Yoshida, N.; Franci, A.; Romo, R.; Rossi-Pool, R.
10.1101/2024.12.11.628069 — neuroscience — Posted on 2025-06-02
4224 Single-cell transcriptomics uncovers that cell-to-cell communication controls p53 activation
Castellano, L.; Robinson, M. E.; Dabrowska, A.; Feldhahn, N.; Ottaviani, S.; Stebbing, J.
10.1101/2025.05.30.657016 — cancer biology — Posted on 2025-06-02
4227 The effect of aging on post-translational modifications of wild-type human SOD1 and the A5V ALS mutant
de Souza, G. F.; Magalhaes, R. S. S.; Neto, J. R. M.; Martins, M.; Follmer, C.; Junqueira, M.; Eleutherio, E. C. A.
10.1101/2025.06.02.657411 — biochemistry — Posted on 2025-06-02
4228 Spatial metabolic gradients in the liver and small intestine
Samarah, L. Z.; Zheng, C.; Xing, X.; Lee, W. D.; Afriat, A.; Chitra, U.; MacArthur, M.; Lu, W.; Jankowski, C. S. R.; Ma, C.; Hunter, C. J.; Raphael, B. J.; Rabinowitz, J. D.
10.1101/2025.06.02.657306 — biochemistry — Posted on 2025-06-02
4230 Time Series GWAS for Iron Deficiency Chlorosis Tolerance in Soybean using Aerial Imagery
Carroll, M. E.; Rairdin, A. M.; Van der Laan, L.; Ferela, A.; Hanumolu, S.; Sarkar, S.; Ganapathysubramanian, B.; Singh, A.; Singh, A. K.
10.1101/2025.05.30.657051 — genetics — Posted on 2025-06-02
4233 Protists Exhibit Stronger and More Recent Oceanic Genetic Structure than Archaeplastida and Metazoa
Gonzalez-Miguens, R.; Galvez-Morante, A.; Torruella, G.; Berney, C.; Casacuberta, E.; Ruiz-Trillo, I.
10.1101/2025.06.02.657477 — microbiology — Posted on 2025-06-02
4234 Human Cytomegalovirus UL78 is a Nuclear-Localized GPCR Necessary for Efficient Reactivation from Latent Infection in CD34+ Hematopoietic Progenitor Cells
Medica, S.; Diggins, N. L.; Denton, M.; Turner, R. L.; Pung, L. J.; Mayo, A. T.; Mitchell, J.; Slind, L.; Nguyen, L. K.; Beechwood, T. A.; Sulgey, G.; Kreklywich, C. N.; Malouli, D.; Caposio, P.; Streblow, D. N.; Hancock, M. H.
10.1101/2025.06.02.657350 — microbiology — Posted on 2025-06-02
4235 Phylogeny-aware comparative genomics of Vibrio vulnificus links genetic traits to pathogenicity
Delgado, L. F.; Riedinger, D. J.; Fernandez-Juarez, V.; Herlemann, D. P. R.; Pansch, C.; Katarzyte, M.; Gyraite, G.; Reusch, T. B. H.; Rakowski, M.; Piwosz, K.; Wozniczka, A.; Benterbusch-Brockmöller, H.; Sperlea, T.; Dupke, S.; Scholz, H. C.; Kube, S.; Riemann, L.; Labrenz, M.; Andersson, A.
10.1101/2025.06.02.657354 — microbiology — Posted on 2025-06-02
4237 Episymbiotic Saccharibacteria suppresses epithelial immunoactivation through Type IV pili and TLR2 dependent endocytosis
Chouhan, D.; Grossman, A. S.; Kerns, K. A.; Stocke, K. S.; Kim, M.; Dong, P.-T.; Kumar, A.; Lei, L.; Lamont, R. J.; McLean, J. S.; He, X.; Bor, B.
10.1101/2025.05.30.656655 — immunology — Posted on 2025-06-02
4239 From Belief to Brain: How Growth Mindset Optimizes Cortico-Striatal Dynamics for Cognitive Development
Zhao, Y.; Cui, J.; Zhang, Z.; Zhao, H.; Xu, J.; Chen, M.; Hao, L.; He, Y.; Wang, H.; Wang, Y.; Wang, D.; Hu, Y.; Han, Z. R.; Tan, S.; Men, W.; Gao, J.; Chen, L.; He, Y.; Tao, S.; Dong, Q.; Qin, S.
10.1101/2022.07.11.499525 — neuroscience — Posted on 2025-06-02
4242 LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics
Tombesi, G.; Kompella, S.; Favetta, G.; Chen, C.; Ornaghi, M.; Zhao, Y.; Morosin, E.; Sevegnani, M.; Lama, A.; Marte, A.; Battisti, I.; Iannotta, L.; Plotegher, N.; Civiero, L.; Onofri, F.; Eickholt, B. J.; Piccoli, G.; Arrigoni, G.; Beccano-Kelly, D.; Manzoni, C.; Parisiadou, L.; Greggio, E.
10.1101/2022.10.31.514622 — neuroscience — Posted on 2025-06-02
4247 Computational design of conformation-biasing mutations to alter protein functions
Cavanagh, P. E.; Xue, A. G.; Dai, S.; Qiang, A.; Matsui, T.; Ting, A. Y.
10.1101/2025.05.03.652001 — biophysics — Posted on 2025-06-02
4248 Quantitative isoform profiling using deep coverage long-read RNA sequencing across early endothelial differentiation
Wissel, D.; Mehlferber, M. M.; Nguyen, K. M.; Pavelko, V.; Tseng, E.; Robinson, M. D.; Sheynkman, G. M.
10.1101/2025.05.30.656561 — bioinformatics — Posted on 2025-06-02
4249 Biocompatible Multi-functional Polymeric Material for Mineralized Tissue Adhesion
Luo, Y.; Zhang, C.; Fulco, S.; Liu, J.; Chen, K.; Hu, Y.; Jiang, Y.; Xu, R.; Rakesh, L.; Ozer, F.; Tertuliano, O.; Turner, K.; Vining, K. H.
10.1101/2025.05.30.656989 — bioengineering — Posted on 2025-06-02
4250 Enabling Plasmid-based Expression in Clostridium kluyveri using a Biparental Methylation-Conjugation System
Agena, E. M.; Badani, A. A.; Linder, B. G.; Gois, I. M.; Dempster, A. W.; Minton, N. P.; Mahadevan, R.; Lawson, C. E.
10.1101/2025.05.30.657078 — bioengineering — Posted on 2025-06-02
4255 Differential metaproteomics of bacteria grown in vitro and in planta reveals functions used during growth on maize roots
Garrell, A.-K.; Cheadle, J.; Crook, N.; Pal, G.; Septer, A. N.; Wagner, M. R.; Beck, A. E.; Kleiner, M.
10.1101/2025.06.02.657423 — microbiology — Posted on 2025-06-02
4259 GENOTYPIC DETECTION OF ANTIBIOTIC-RESISTANT GENES IN EMERGING BACTERIAL PATHOGENS FROM NEONATAL SEPSIS PATIENTS IN LAGOS
Adegboyega, H. O.; Banjo, T. A.; Deji-Agboola, A. M.; Iwalokun, B.; Mutiu, W. B.; Osinupebi, O. A.; Shorunmu, T. O.; Oladoja, F. A.; Fatungase, O. M.; Adeyanju, M. M.; Akindele, R. A.; Fakunle, P. B.; Olabode, B. A.; Ajayi, O. O.; Onadeko, O.; Oyelekan, A. A. A.; Oritogun, K. S.; Ariyibi, S. O.; Omirin, E. S.
10.1101/2025.06.02.657359 — microbiology — Posted on 2025-06-02
4263 Differential Decay of Multiple eNA Components from a Cetacean
Brandao-Dias, P. F.; Shaffer, M.; Guri, G.; Parsons, K. M.; Kelly, R. P.; Allan, E. A.
10.1101/2025.05.09.653189 — molecular biology — Posted on 2025-06-02
4264 Antibiotic potentiation and inhibition of cross-resistance in pathogens associated with cystic fibrosis
Kaderabkova, N.; Furniss, R. C. D.; Maslova, E.; Potter, K. E.; Eisaiankhongi, L.; Bernal, P.; Filloux, A.; Landeta, C.; Gonzalez, D.; McCarthy, R. R.; Mavridou, D.
10.1101/2023.08.02.551661 — microbiology — Posted on 2025-06-02
4265 Mapping early patterning events in human neural development usingan in-vitro microfluidic stem cell model
Rathore, G. S.; Ankjaer, M.; Rifes, P.; Hanninen, E.; Calleja, F. S.; Rusimbi, C.; Kajtez, J.; Nygaard, A. H.; Piilgaard, L. S.; Dubonyte, U.; Norgaard, Z. A.; Christensen, J. B.; Egerod, K. L.; Camp, J. G.; Pers, T.; Treutlein, B.; Kirkeby, A.
10.1101/2025.05.23.655442 — neuroscience — Posted on 2025-06-02
4266 Human gut commensal Alistipes timonensis modulates the host lipidome and delivers anti-inflammatory outer membrane vesicles to suppress colitis in an Il10-deficient mouse model
Older, E. A.; Mitchell, M. K.; Campbell, A.; Lian, X.; Madden, M.; Wang, Y.; van de Wal, L. E.; Zaw, T.; VanderVeen, B. N.; Tatum, R.; Murphy, E. A.; Chen, Y.-H.; Fan, D.; Ellermann, M.; Li, J.
10.1101/2024.10.23.619966 — biochemistry — Posted on 2025-06-02
4270 AcrIF11 is a potent CRISPR-specific ADP-ribosyltransferase encoded by phage and plasmid
Chen, D. F.; Roe, L. T.; Li, Y.; Borges, A. L.; Zhang, J. Y.; Babbar, P.; Maji, S.; Stevens, M. G. V.; Correy, G. J.; Diolaiti, M. E.; Smith, D. H.; Ashworth, A.; Stroud, R. M.; Kelly, M. J. S.; Bondy-Denomy, J.; Fraser, J. S.
10.1101/2024.08.26.609590 — microbiology — Posted on 2025-06-02
4271 Intrinsic dynamic shapes responses to external stimulation in the human brain
Nentwich, M.; Leszczynski, M.; Schroeder, C. E.; Bickel, S.; Parra, L. C.
10.1101/2024.08.05.606665 — neuroscience — Posted on 2025-06-02
4273 Automated Classification of Sleep-Wake States and Seizures in Mice
Harvey, B. J.; Olah, V. J.; Aiani, L. M.; Rosenberg, L. I.; Lasky, D. J.; Moxon, B.; Pedersen, N. P.
10.1101/2023.04.07.536063 — neuroscience — Posted on 2025-06-02
4275 Microtubule forces drive nuclear damage in LMNA cardiomyopathy
Amiad Pavlov, D.; Heffler, J.; Corredera, C. S.; Dehghany, M.; Shen, K. M.; Zuela-Sopilniak, N.; Randell, R.; Uchida, K.; Jain, R.; Shenoy, V.; Lammerding, J.; Prosser, B. L.
10.1101/2024.02.10.579774 — cell biology — Posted on 2025-06-02
4277 Whole-brain meso-vein imaging in living humans using fast 7 T MRI
Gulban, O. F.; Stirnberg, R.; Tse, D. H. Y.; Pizzuti, A.; Koiso, K.; Archila-Melendez, M. E.; Huber, R.; Bollmann, S.; Goebel, R.; Kay, K.; Ivanov, D.
10.1101/2025.03.23.644588 — neuroscience — Posted on 2025-06-02
4278 Evolution of object identity information in sensorimotor cortex throughout grasp
Yan, Y.; Sobinov, A. R.; Goodman, J. M.; Okorokova, E. V.; Miller, L. E.; Bensmaia, S. J.
10.1101/2024.10.11.617909 — neuroscience — Posted on 2025-06-02
4280 Persistent dopamine-dependent remodeling of the neural transcriptome in response to pregnancy and postpartum
Chan, J. C.; Di Salvo, G.; Cunningham, A. M.; Dutta, S.; Brindley, E. A.; Weekley, B. H.; Wan, E.; Zhang, C.; Mechawar, N.; Turecki, G.; Maze, I.
10.1101/2025.02.20.639313 — neuroscience — Posted on 2025-06-02
4282 FEDRANN: effective overlap graph construction based on dimensionality reduction and approximate nearest neighbors
Zhang, J.-Y.; Miao, C.; Qiu, T.; Xia, X.; He, L.; He, J.; Sun, Y.; Zeng, T.; Li, Y.; Xu, X.; Ruan, Y.; Dong, Y.
10.1101/2025.05.30.656979 — bioinformatics — Posted on 2025-06-02
4284 MARLOWE: Taxonomic Characterization of Unknown Samples for Forensics Using De Novo Peptide Identification
Jenson, S. C.; Chu, F.; Alves, G.; Ogurtsov, A. Y.; Barente, A. S.; Crockett, D. L.; Lamar, N. C.; Merkley, E. D.; Yu, Y.-K.; Jarman, K. H.
10.1101/2024.09.30.615220 — bioinformatics — Posted on 2025-06-02
4288 Persistent Decision-Making in Mice, Monkeys, and Humans
Laurie, V.-J.; Shourkeshti, A.; Chen, C. S.; Herman, A. B.; Grissom, N. M.; Ebitz, R. B.
10.1101/2024.05.07.592970 — animal behavior and cognition — Posted on 2025-06-02
4290 A haplotype-resolved view of human gene regulation
Vollger, M. R.; Swanson, E. G.; Neph, S. J.; Ranchalis, J.; Munson, K. M.; Ho, C.-H.; Cheng, Y. H. H.; Sedeno-Cortes, A. E.; Fondrie, W. E.; Bohaczuk, S. C.; Dippel, M. A.; Mao, Y.; Parmalee, N. L.; Mallory, B. J.; Harvey, W. T.; Kwon, Y.; Garcia, G. H.; Hoekzema, K.; Meyer, J. G.; Cicek, M.; Eichler, E. E.; Noble, W. S.; Witten, D. M.; Bennett, J. T.; Ray, J. P.; Stergachis, A. B.
10.1101/2024.06.14.599122 — genomics — Posted on 2025-06-02
4291 Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity
Sayeed, K.; Parameswaran, S.; Beucler, M. J.; Edsall, L. E.; VonHandorf, A.; Crowther, A.; Donmez, O. A.; Hass, M. R.; Richards, S.; Forney, C. R.; Hesse, H. K.; Jones, S. H.; Dunn, K. A.; Wright, J.; Leong, M. M.; Murray-Nerger, L. A.; Yechoor, V. K.; Gewurz, B. E.; Kaufman, K. M.; Harley, J. B.; Zhao, B.; Miller, W. E.; Kottyan, L. C.; Weirauch, M. T.
10.1101/2024.04.12.588762 — genomics — Posted on 2025-06-02
4292 A curated dataset and web application for Integrative Analysis of Ancient DNA from Britain and Ireland
Metz, S.; Fischer, C.-E.; Bleasdale, M.; Castells Navarro, L.; Buster, L.; Legge, M.; Reich, D.; Armit, I.
10.1101/2025.05.30.657009 — genetics — Posted on 2025-06-02
4300 Synthetic Serum Markers Enable Noninvasive Monitoring of Gene Expression in Primate Brains
Lee, S.; Romac, M.; Watanabe, S.; Chernov, M.; Li, H.; Raisley, E.; Szablowski, J. O.; Costa, V. D.
10.1101/2025.06.01.657212 — neuroscience — Posted on 2025-06-02
4302 C9orf72 polyGA knock-in mice exhibit mild motor and proteomic changes consistent with ALS/FTD
Milioto, C.; Carcole, M.; Zanovello, M.; Ahmed, M.; Nirujogi, R. S.; Biggs, D.; Katona, E.; Glaria, I.; Santos, A.; Devoy, A.; Fratta, P.; Alessi, D. R.; Davies, B.; Greensmith, L.; Fisher, E.; Isaacs, A. M.
10.1101/2025.05.30.656994 — neuroscience — Posted on 2025-06-02
4305 Phenotypic and transcriptomic characterization of bicalutamide and enzalutamide resistance in castration-resistant prostate cancer cells
Natkin, R.; Paloneva, M. I.; Raittinen, P. V.; Syvala, H.; Blauer, M.; Tammela, T. L.; Ilmonen, P.; Nykter, M.; Siltari, A.; Murtola, T. J.
10.1101/2025.05.30.656961 — cancer biology — Posted on 2025-06-02
4310 Visual working memory precision is under voluntary control
Sahakian, A.; Koevoet, D.; Paffen, C. L. E.; Gayet, S.; Van der Stigchel, S.
10.1101/2025.05.29.656854 — neuroscience — Posted on 2025-06-02
4311 Spine-Prints: Transposing Brain Fingerprints to the Spinal Cord
Ricchi, I.; Santoro, A.; Kinany, N.; Landelle, C.; Khatibi, A.; Vahdat, S.; Doyon, J.; Barry, R. L.; Van De Ville, D.
10.1101/2025.05.30.656545 — neuroscience — Posted on 2025-06-02
4314 Gestational Chronic Intermittent Hypoxia Triggers Maternal Inflammation and Disrupts Placental Stress Responses
Gardner, J. J.; Oliveira da Silva, R. d. N.; Bradshaw, J. L.; Mabry, S.; Wilson, E. N.; Hula, N.; Tucker, S. M.; Gorham, I. K.; Escalera, D.; Lopez, L.; Phillips, N. R.; Cunningham, R. L.; Goulopoulou, S.
10.1101/2025.05.29.656944 — physiology — Posted on 2025-06-02
4315 CASP16 protein monomer structure prediction assessment
Yuan, R.; Zhang, J.; Kryshtafovych, A.; Schaeffer, R. D.; Zhou, J.; Cong, Q.; Grishin, N. V.
10.1101/2025.05.29.656942 — biophysics — Posted on 2025-06-02
4324 A cell atlas of the developing human outflow tract of the heart and its adult derivatives
Leshem, R.; Murtuza Baker, S.; Mallen, J.; Wang, L.; Dark, J.; Rattray, M.; Sharrocks, A.; Piper Hanley, K.; Hanley, N.; Bamforth, S.; Bobola, N.
10.1101/2023.04.05.535627 — developmental biology — Posted on 2025-06-02
4325 Conserved and Unique Features of Terminal Telomeric Sequences in ALT-Positive Cancer Cells
Azeroglu, B.; Wu, W.; Pavani, R.; Sandhu, R.; Matsumoto, T.; Nussenzweig, A.; Lazzerini Denchi, E.
10.1101/2025.02.27.640565 — molecular biology — Posted on 2025-06-02
4327 Synthetic Serum Markers Enable Noninvasive Monitoring of Gene Expression in Primate Brains
Lee, S.; Romac, M.; Romac, M. D.; Chernov, M.; Li, H.; Raisley, E.; Szablowski, J. O.; Costa, V. D.
10.1101/2025.06.01.657212 — neuroscience — Posted on 2025-06-02
4330 Informed Data-Independent Acquisition Enables Targeted Quantification of Key Regulatory Proteins in Cell Fate Decision at Single-Cell Resolution
Woessmann, J.; Petrosius, V.; Schovsbo, S.; Arrey, T. N.; Furtwaengler, B.; Op de Beeck, J.; Damoc, E.; Porse, B. T.; Schoof, E. M.
10.1101/2025.05.30.656945 — systems biology — Posted on 2025-06-02
4331 Active learnings impact on student course performance in STEM varies by type and intensity
Xu, S.; Velasco, V.; Hill, M. J.; Tran, E.; Agrawal, S.; Arroyo, E. N.; Behling, S.; Chambwe, N.; Cintron, D. L.; Cooper, J. D.; Dunster, G.; Grummer, J. A.; Hennessey, K.; Hsiao, J.; Iranon, N.; Jones, L.; Jordt, H.; Keller, M.; Lacey, M. E.; Littlefield, C. E.; Lowe, A.; Newman, S.; Okolo, V.; Olroyd, S.; Peecook, B. R.; Pickett, S. B.; Slager, D. L.; Caviedes-Solis, I. W.; Stanchak, K. E.; Sundaravaradan, V.; Valdebenito, C.; Williams, C. R.; Zinsli, K. A.; Freeman, S.; Theobald, E. J.
10.1101/2025.06.01.657285 — scientific communication and education — Posted on 2025-06-02
4332 Prediction of harvest-related traits in barley using high-throughput phenotyping data and machine learning
Tietze, H.; Abdelhakim, L.; Pleskacova, B.; Kurtz-Sohn, A.; Fridman, E.; Nikoloski, Z.; Panzarova, K.
10.1101/2025.05.29.656856 — plant biology — Posted on 2025-06-02
4334 Perinatal Asphyxia Alters Physiological Responses and Ex Vivo Cardiovascular Function of Preterm Growth-Restricted Lambs
Azman, Z.; Piscopo, B. R.; Sutherland, A. E.; Thiel, A.; Zahra, V.; Pham, Y.; Nitsos, I.; Hossain, M. M.; Malhotra, A.; Miller, S. L.; Bubb, K. J.; Polglase, G. R.; Allison, B. J.
10.1101/2025.05.27.656490 — physiology — Posted on 2025-06-02
4335 Regulation of Aldosterone Secretion by Substance P and the NK1 Receptor in Aldosterone-Producing Adenomas
Lopez, A.-G.; Duparc, C.; Renouf, S.; D'Agostino, M.; De Sousa, K.; Amar, L.; Defortescu, G.; Manceau, G.; Sabourin, J.-C.; Fernandes-Rosa, F. L.; Zennaro, M.-C.; Meatchi, T.; Nicolas, G.; Louiset, E.; Lefebvre, H.
10.1101/2025.05.28.656733 — physiology — Posted on 2025-06-02
4342 Structure of a novel contractile injection system in Salmonella enterica subsp. salamae
Ejaz, R. N.; Funke, K.; Kielkopf, C. S.; Martin, F. J. O.; Siborova, M.; Hendriks, I. A.; Sofos, N. H.; Pape, T. H.; Steiner-Rebrova, E. M.; Nielsen, M. L.; Erhardt, M.; Taylor, N. M. I.
10.1101/2025.06.01.657177 — microbiology — Posted on 2025-06-02
4345 From Morphology to Computation: How Synaptic Organization Shapes Place Fields in CA1 Pyramidal Neurons
Tasciotti, S.; Iascone, D. M.; Chavlis, S.; Hammond, L.; Katz, Y.; Losonczy, A.; Polleaux, F.; Poirazi, P.
10.1101/2025.05.30.657022 — neuroscience — Posted on 2025-06-02
4346 Large Language Models Reveal the Neural Tracking of Linguistic Context in Attended and Unattended Multi-Talker Speech
Puffay, C.; Mischler, G.; Choudhari, V.; Vanthornhout, J.; Bickel, S.; Mehta, A. D.; Schevon, C. A.; McKhann, G. M.; Van hamme, H.; Francart, T.; Mesgarani, N.
10.1101/2025.04.24.648897 — neuroscience — Posted on 2025-06-02
4348 NEUROGLIAL CB1 RECEPTORS CONTROL NAVIGATION STRATEGIES
Egana-Huguet, J.; Sangroniz-Beltran, L.; Baraibar, A. M.; Reyes-Velasquez, P.; Landgraf, N.; Torres-Maldonado, P.; Rodriguez-Cedres, C.; Julio-Kalajzic, F.; Piriz, J.; Ramos-Uriarte, A.; Grandes, P.; Marsicano, G.; Mato, S.; Ceprian, M.; Soria-Gomez, E.
10.1101/2025.05.27.656352 — neuroscience — Posted on 2025-06-02
4349 Separate timescales for spatial and anatomical information processing of body stimuli
Waltzing, B. M.; McAteer, S.; Moreno-Verdu, M.; Van Caenegem, E. E.; Du, Y.; Hardwick, R. M.
10.1101/2024.10.07.616993 — neuroscience — Posted on 2025-06-02
4350 An in vitro human vessel to study Neisseria meningitidis colonization and vascular damages
Pinon, L.; Chabaud, M.; Nivoit, P.; Wong-Ng, J.; Nguyen, T.-T.; Paul, V.; Bouquerel, C.; Goussard, S.; Smilovici, P.; Frachon, E.; Obino, D.; Gobaa, S.; Dumenil, G.
10.1101/2024.02.09.579276 — synthetic biology — Posted on 2025-06-02
4352 IRE1 activity regulates tumour and microenvironment cell lineage states while stratifying localised and metastatic prostate cancer.
Doultsinos, D.; Tomljanovic, I.; Pilalis, E.; Abusamra, S.; Parmentier, R.; Bridges, I. E.; Figiel, S.; Zekri, Y.; Hester, J.; Leach, D.; Bevan, C. L.; Lamb, A. D.; Zwart, W.; Chatziioannou, A.; Le Magnen, C.; Mills, I. G.
10.1101/2025.03.13.643042 — cancer biology — Posted on 2025-06-02
4356 Genomic and Phenotypic Characterization of Mupirocin Resistant Staphylococcus aureus Clinical Isolates
Virgillio, A. M.; Felton, E. A.; Jackson, J. K.; Kennedy, S. J.; Becker, D. N.; Lima, A.; Atrubin, K.; Cella, E.; Azarian, T.; Silbert, S.; Shaw, L. N.; Kim, K.
10.1101/2025.04.16.648996 — microbiology — Posted on 2025-06-02
4358 Chorionic Gonadotropin Beta 7 is a marker of immune evasion in cancer
McKellar, S. A.; Pineda, J. M. B.; Lattupally, R.; Codd, A. S.; Newell, E.; Lu, S. X.; Bradley, R. K.
10.1101/2025.05.28.656535 — cancer biology — Posted on 2025-06-02
4360 A NEW DYSTROPHIN DEFICIENT RAT MODEL MIRRORING EXON SKIPPING IN PATIENTS WITH DMD EXON 45 DELETIONS
JABER, A.; WANG, T.; DAOUD, C.; ALBINI, S.; CORRE, G.; BELLEC, J.; BOVOLENTA, M.; DORVAL, A.; DUBOIS, A.; PHILIDET, L.; WARTHI, G.; RICHARD, I.
10.1101/2025.05.30.656540 — genetics — Posted on 2025-06-02
4361 Viral adsorption to Moore swabs in passive wastewater sampling
Rao, G.; Purvis, T.; Cha, G.; Dalton, J.; Fisher, M.; Graham, K. E.; Konstantinidis, K. T.; Linden, Y.; Bivins, A.; Brinton, M. A.; Stauber, C.; Brown, J.
10.1101/2025.05.30.656954 — microbiology — Posted on 2025-06-02
4362 Lack of functional STING modulates immunity but does not protect dopaminergic neurons in the alpha-synuclein preformed fibrils Parkinson's Disease mouse model
Klaestrup, I. H.; Reinert, L. S.; Ferreira, S. A.; Lauritsen, J.; Toft, G. U.; Gram, H.; Jensen, P. H.; Paludan, S. R.; Romero-Ramos, M.
10.1101/2025.05.30.656977 — neuroscience — Posted on 2025-06-02
4363 Slow-Timescale Regulation of Dopamine Release and Mating Drive over Days
Sunkavalli, P. S.; Madara, J. C.; Christenson, L. F.; Diaz, A.; Chen, J.; Ravotto, L.; Patriarchi, T.; Andermann, M. L.; Zhang, S. X.
10.1101/2025.05.29.656898 — neuroscience — Posted on 2025-06-02
4364 Shared and distinct microRNA profiles between HT22, N2A and SH-SY5Y cell lines and primary mouse hippocampal neurons
Jimenez Mateos, E. M.; Murphy, R.; Villegas-Salmeron, J.; Sanz-Rodriguez, A.; Engel, T.; Mooney, C.; Henshall, D. C.
10.1101/2025.06.01.657291 — neuroscience — Posted on 2025-06-02
4365 Genotype-Specific Electroretinogram Signatures in Drosophila: Implications for Neurodegeneration Models Using w1118 Backgrounds
Manuel, N.; Mallipudi, M.; Gajwani, A.; Gopalkrishna Shetty Sreenivasa Murthy, S.; Jupiter, D. C.; Krishnan, B.
10.1101/2024.11.29.626125 — neuroscience — Posted on 2025-06-02
4366 Adverse prognosis of GM-CSF expression in human cutaneous melanoma
Garcia-Martinez, E.; Nieto-Valle, A.; Barrio-Alonso, C.; Lopez-Navarro, B.; Aviles-Izquierdo, J. A.; Parra-Blanco, V.; Gutierrez-Seijo, A.; Sanchez-Mateos, P.; Samaniego Garcia, R.
10.1101/2025.05.30.656980 — cancer biology — Posted on 2025-06-02
4367 Soil to human health continuum: Exploring ergothioneine and mycorrhizal fungi in shaping the wheat microbiome
Ravi, S. S. N.; Pipinos, A.; Insley, N.; Kan, J.; Zinati, G.; Smith, A.; Heller, W.; Bais, H.
10.1101/2025.05.28.656623 — plant biology — Posted on 2025-06-02
4368 Effect of Chronic Stress on Whole Blood Transcriptome: A Meta-Analysis of Publicly Available Datasets from Rodent Models
Flandreau, E. I.; Nguyen, D. M.; Hagenauer, M. H.; Nguyen, M.; Kim, H.; Duan, T.; Bader, A.; Watson, S.; Akil, H.
10.1101/2025.05.30.657043 — genomics — Posted on 2025-06-01
4369 Non-canonical enhancers control gene expression and cell fate in human pluripotent stem cells
Cao, Y.; Dovgusha, O.; Ebrahimi, A.; Bevan, S.; Widmer, L.; Torabi, F.; Kurlovich, J.; Rodriguez-Polo, I.; Khan, S.; Patel, M.; Pradeepa, M. M.; Guenesdogan, U.; Schoenfelder, S.
10.1101/2025.06.01.657118 — genomics — Posted on 2025-06-01
4375 Nucleus accumbens neuron subtype translatome signatures in socially stress females
Kumar, G.; Franco, D.; Basu, M.; Olusakin, J.; Campbell, R.; Ament, S. A.; Fox, M.; Lobo, M. K.
10.1101/2025.06.01.656319 — neuroscience — Posted on 2025-06-01
4376 Uncovering the invisible giant: Amyloid β plaques and their proposed association with waste removal in Alzheimer-affected human hippocampus
Fabian-Fine, R.; Roman, A. G.; Winters, M. J.; Lathram, K. J.; Bennett, C. H.; Kipingi, L. K.; Paul, C. M.; Altman, L. M.; Carrillo, I. C.; Joyce, F. M.; Kragh, L. A.; McKnight, T. J.; Reding, C. J.; Reiderer, L. J.; Rivera, L. J.; Steen, H. A.; Weaver, A. L.
10.1101/2025.06.01.657219 — neuroscience — Posted on 2025-06-01
4378 Astrocyte regional specialization is shaped by postnatal development
Schroeder, M. E.; McCormack, D. M.; Metzner, L.; Kang, J.; Li, K. X.; Yu, E.; Melamed, L.; Levandowski, K. M.; Zaniewski, H.; Zhang, Q.; Boyden, E.; Krienen, F. M.; Feng, G.
10.1101/2024.10.11.617802 — neuroscience — Posted on 2025-06-01
4379 Correlative light and electron microscopy reveals the fine circuit structure underlying evidence accumulation in larval zebrafish
Boulanger-Weill, J.; Kaempf, F.; Schuhknecht, G. F. P.; Schalek, R. L.; Petkova, M.; Vohra, S. K.; Wu, Y.; Savaliya, J. H.; Tiller, R.; Herrera, K. J.; Naumann, H.; Eberle, M.; Rencken, S.; Stingl, M.; Hebling, A.; Hockling, D.; Slangewal, K.; Deng, Z.; Wang, R. C.; Zhang, L. L.; Kirchberger, K. N.; Bianco, I. H.; Baum, D.; Bene, F. D.; Engert, F.; Lichtman, J. W.; Bahl, A.
10.1101/2025.03.14.643363 — neuroscience — Posted on 2025-06-01
4380 Neuronal firing rate diversity lowers the dimension of population covariability
Tian, G. J.; Zhu, O.; Shirhatti, V.; Greenspon, C.; Downey, J. E.; Freedman, D. J.; Doiron, B.
10.1101/2024.08.30.610535 — neuroscience — Posted on 2025-06-01
4383 Leveraging autophagy and pyrimidine metabolism to target pancreatic cancer
Dufresne, S.; Kuna, R. S.; Wong, K.; Komarla, A.; Rock, A.; Rosada-Encarnacion, J.; Shen, C.; Mondal, P.; Parham, L. R.; Layng, F. I.; Peck, K. L.; Fowler, A.; Lowy, A. M.; Engle, D.; Tiriac, H.; Shaw, R.; Cosford, N.; Metallo, C.; Towers, C. G.
10.1101/2025.05.29.656904 — cancer biology — Posted on 2025-06-01
4389 Structure of a novel contractile injection system in subsp.
Ejaz, R. N.; Funke, K.; Kielkopf, C. S.; Martin, F. J. O.; Siborova, M.; Hendriks, I. A.; Sofos, N. H.; Pape, T. H.; Steiner-Rebrova, E. M.; Nielsen, M. L.; Erhardt, M.; Taylor, N. M. I.
10.1101/2025.06.01.657177 — microbiology — Posted on 2025-06-01
4390 Expanding the MR1 ligandome using chemical class-specific fragmentation and molecular networking
Lecchi, C.; Vacchini, A.; Sainas, S.; Lolli, M. L.; Luedtke, M. W.; Mori, L.; De Libero, G.; Balbo, S.; Villalta, P. W.
10.1101/2025.05.29.656472 — immunology — Posted on 2025-06-01
4392 Cone bipolar cell synapses generate transient versus sustained signals in parallel ON pathways of the mouse retina
Kuo, S. P.; Yu, W.-Q.; Srivastava, P.; Okawa, H.; Della Santina, L.; Berson, D. M.; Awatramani, G. B.; Wong, R. O.; Rieke, F.
10.1101/2024.05.13.593825 — neuroscience — Posted on 2025-06-01
4393 Phase-synchronized 40Hz tACS and iTBS effects on gamma oscillations
Glinski, B.; Salehinehjad, M. A.; Takahashi, K.; Jamil, A.; Yavari, F.; Kuo, M.-F.; Nitsche, M.
10.1101/2025.03.14.643227 — neuroscience — Posted on 2025-06-01
4394 EXOSC3 S1-domain variants implicated in PCH1b alter RNA exosome cap subunit abundance and thermal stability disrupting rRNA processing and targeting of AU-rich mRNA
Runnebohm, A. M.; Wijeratne, H. S.; Barron, M. P.; Smith-Kinnaman, W. R.; Rooney, J. D.; Peck Justice, S. A.; Cureton, L. A.; Holland, A.; Ghalei, H.; Pelletier, S.; Doud, E. H.; Vilseck, J. Z.; Mosley, A. L.
10.1101/2025.05.31.657176 — systems biology — Posted on 2025-06-01
4395 Voltage-dependent anion channels are mitophagy receptors mediating the recycling of depolarized mitochondria in Arabidopsis
MA, W.; MA, J.; ZHANG, K.; ZHENG, X.; WANG, P.; FENG, L.; MING, S.; ZHUANG, X.; ZHOU, J.; Gao, C.; KANG, B. H.
10.1101/2025.05.29.656919 — plant biology — Posted on 2025-06-01
4397 Complement factor D (adipsin) mediates pressure-pain hypersensitivity post destabilization of medial meniscus injury
Tjandra, P. M.; Andoko, B. A.; Kim, J. A.; Gomez, A. G.; Sar, S.; Aepala, M. R.; Pham, T. T. K.; Dumlao, D.; Welhaven, H. D.; Collins, K. H.
10.1101/2025.05.29.656852 — physiology — Posted on 2025-06-01
4399 Tumor-specific draining lymph node CD8 T cells orchestrate an anti-tumor response to neoadjuvant PD-1 immune checkpoint blockade
Honigsberg, R.; Cruz, T. D.; Yoffe, L.; Tang, M. S.; Ozgenel, D. O.; Markowitz, G.; Micheal, M.; Singh, A.; Altorki, N. K.; Elemento, O.; Villena-Vargas, J.
10.1101/2025.04.27.650862 — cancer biology — Posted on 2025-06-01
4400 MicroCT enables simultaneous longitudinal tracking of murine pancreatic cancer progression and cachexia
Pelz, K. R.; Jimenez, P.; Daniel, C. J.; Newton, S. D.; Cunningham, M.; Sears, R. C.; Worth, P. J.; Brody, J. R.; Zimmers, T. A.
10.1101/2025.05.29.656943 — cancer biology — Posted on 2025-06-01
4401 Chemotaxis of branched cells in complex environments
Liu, J.; Ron, J. E.; Rinaldi, G.; Williantarra, I.; Georgantzoglou, A.; de Vries, I.; Sixt, M.; Sarris, M.; Gov, N.
10.1101/2025.05.27.656457 — biophysics — Posted on 2025-06-01
4402 Single-molecule FRET and tracking of transfected biomolecules: multi-dimensional protein dynamics in living cells
Anandamurugan, A.; Eidloth, A.; Frank, V.; Wortmann, P.; Schrangl, L.; Lan, C.; Schuetz, G.; Hugel, T.
10.1101/2023.09.15.557875 — biophysics — Posted on 2025-06-01
4405 A photostable genetically encoded voltage indicator for imaging neural activities in tissue and live animals
Cao, C.; Zhu, R.; Zhou, S.; Zhao, Z.; Lin, C.; Liu, S.; Peng, L.; Subach, F. V.; Piatkevich, K. D.; Zou, P.
10.1101/2025.05.29.656768 — bioengineering — Posted on 2025-06-01
4407 The Na+-pumping mechanism driven by redox reactions in the NADH-quinone oxidoreductase from Vibrio cholerae relies on dynamic conformational changes
Ishikawa-Fukuda, M.; Seki, T.; Kishikawa, J.-i.; Takahiro, M.; Okazaki, K.-i.; Kato, T.; Barquera, B.; Miyoshi, H.; Murai, M.
10.1101/2025.06.01.656757 — biochemistry — Posted on 2025-06-01
4412 HIGH CO2 LEVELS OVERCOME THE NIGHTTIME LETHALITY OF CIRCADIAN MUTANTS IN CYANOBACTERIA
Mendana, A.; Santos-Merino, M.; Dominguez-Quintero, M.; Gutierrez-Lanza, R.; Ducat, D.; Fernandez-Lopez, R.
10.1101/2025.06.01.657271 — microbiology — Posted on 2025-06-01
4414 IFITM1 and IFITM3 cooperate to restrict virus entry in endolysosomes
Wilt, I.; Jolley, A. A.; Rahman, K.; Lai, K. K.; Shi, G.; Andresson, T.; Compton, A. A.
10.1101/2025.06.01.657267 — microbiology — Posted on 2025-06-01
4415 Macrophages Lacking TSC2 have mTORC1-dependent GPNMB Augmentation Ameliorating Cardiac Ischemia-Reperfusion Injury
Keykhaei, M.; Koleini, N.; Meddeb, M.; Tajdini, M.; Rezaee, M.; Huang, Q.; Panesar, T.; Adamo, L.; Ranek, M.; Kass, D. A.
10.1101/2025.05.29.656917 — immunology — Posted on 2025-06-01
4417 Developmentally-specific physiological and metabolic responses support drought resilience in switchgrass and constrains biofuel yield
Basyal, B.; Li, X.; Pargulski, V.; Fu, X.; Nightingale, N.; Overmyer, K.; Coon, J.; Zhang, Y.; Benucci, G. M. N.; Last, R.; Sato, T.; Walker, B.
10.1101/2025.05.29.656847 — plant biology — Posted on 2025-06-01
4421 Automated registration of spatial expression data scales multimodal integration to large cohorts
Harrigan, C. F.; Lam, C. Y.; Chen, D.; Lai, C.; Bremner, R. F.; Jackson, H. W.; Campbell, K.
10.1101/2025.05.29.656851 — bioinformatics — Posted on 2025-06-01
4424 A Temporal Single-Cell Multi-Omics Atlas of Murine Pancreatic Islet Remodeling During Hyperglycaemia Progression
Singh, S.; Pavan, M. K.; Barella, L. F.; Telang, J.; Shree, A.; Agarwal, S.; Goel, A.; Thaleshwar, S. i.; Wess, J.; Zafar, H.; Pydi, S. P.
10.1101/2025.05.29.656754 — genomics — Posted on 2025-06-01
4428 Developmental system drift in dorsoventral patterning is linked to transitions to autonomous development in Annelida
Carrillo-Baltodano, A. M.; Haillot, E.; Meha, S. M.; Luqman, I.; Pashaj, A.; Lee, Y.-J.; Lu, T.-M.; Ferrier, D. E. K.; Schneider, S. Q.; Martin-Duran, J. M.
10.1101/2025.05.29.656861 — developmental biology — Posted on 2025-06-01
4431 EXTENDING PROTEIN LANGUAGE MODELS TO A VIRAL GENOMIC SCALE USING BIOLOGICALLY INDUCED SPARSE ATTENTION
Dejean, T. L.; Ferrell, B. D.; Sawhney, R.; Harrigan, W.; Polson, S. W.; Wommack, K. E.; Belcaid, M.
10.1101/2025.05.29.656907 — bioinformatics — Posted on 2025-06-01
4433 Cell Type Specific Aging Transcriptional Signatures of Human Retina Through Integrated Machine Learning and Single-Cell Transcriptomics
Yang, L.; Lin, S.; Tao, Y.; Pan, Q.; Cai, T.; Ye, Y.; Liu, J.; Zhou, Y.; Shao, Y.; Yi, Q.; Lu, Z. H.; Chen, L.; McKay, G.; Rankin, R.; Li, F.; Meng, W.
10.1101/2025.05.29.656930 — bioinformatics — Posted on 2025-06-01
4438 Novel insights into the genome organization of Rhizobiaceae: identification of linear plasmids
Kuzmanovic, N.; Wick, R. R.; Kalita, M.; Pulawska, J.; DiCenzo, G. C.; Hynes, M. F.; Smalla, K.; Babin, D.; Thuenen, T.
10.1101/2025.05.29.656789 — genomics — Posted on 2025-06-01
4439 Single-cell Characterization of DNA Hydroxymethylation of the Mouse Brain During Aging
Bai, Y.; Yuan, T.; Ren, L.; Huan, Y.; Yang, F.; Li, Y.; Zhang, A.; Liu, Y.; Tian, T.; Kang, N.; Chen, D.; Xie, X.; Wang, Q.; Chen, W.; Zheng, Y.; Xie, X. S.; Cao, Y.
10.1101/2025.05.29.656780 — genetics — Posted on 2025-06-01
4440 From Synthetic to Biological Nitrification Inhibition: Advancing Stabilization of Organic Fertilizers
Vega-Mas, I.; Mancia, A.; Maggetto, L.; Murillo, H.; Debacq, A.; Heinesch, B.; Boland, F.; Krause, H.-M.; Vanderschuren, H.; Thonar, C.
10.1101/2025.05.29.656819 — plant biology — Posted on 2025-06-01
4442 Plastimos: a live cell imaging-based framework to study dynamics of EMT-mediated cellular plasticity in breast cancer
Hosseini, H.; Sameri, S.; Das, D.; Materna-Reichelt, S.; Stojanovic Guzvic, N.; Wöhrl, L.; Hoffmann, M.
10.1101/2025.05.28.656591 — bioinformatics — Posted on 2025-06-01
4444 Spatial metabolomics reveals persistent localized niche-specific metabolic failure in kidneys following ischemia-reperfusion injury
Rietjens, R. G. J.; Manzato, B.; van den Berg, B. M.; Mahfouz, A.; Giera, M.; Dumas, S. J.; Wang, G.; Rabelink, T. J.
10.1101/2025.05.27.656326 — biochemistry — Posted on 2025-06-01
4446 Host adaptation and genome evolution of the broad host range fungal rust pathogen, Austropuccinia psidii
Luo, Z.; Tobias, P.; Singh, L.; Dong, C.; Martino, A. M.; Quecine, M.; Massola Junior, N. S.; Silva, L. C. A.; Li, J.; Singh, S.; Zhang, Z.; Jones, A.; Park, R. F.; Schwessinger, B.; Edwards, R.; Boufleur, T.
10.1101/2025.05.29.656941 — microbiology — Posted on 2025-06-01
4447 Peptides alleviate cognitive impairment by inhibiting and disassembling amyloid-beta aggregates in Alzheimer disease
Gao, W.; Gao, B.; Wang, S.; Wu, D.; Mei, P.; Geng, L.; Li, C.; Li, Y.; Liu, X.; Pan, J.; Huang, J.; Deng, Y.; Chen, X.; saiyin, H.; Yu, H.; Li, S.; Zhang, Q.; Xu, B.; Huang, F.; Ming, C.; Wu, H.; Li, J.
10.1101/2025.05.28.656730 — neuroscience — Posted on 2025-06-01
4448 Rab2 and Arl8/BORC control retrograde axonal transport of dense core vesicles via Syd/dJIP3/4 and RUFY dynein adaptors
Lund, V. K.; Chirco, A.; Caliari, M.; Larsen, A. H.; Gether, U.; Madsen, K. L.; Wierer, M.; Kjaerulff, O.
10.1101/2025.05.28.656585 — neuroscience — Posted on 2025-06-01
4449 EEG reveals how space acts as a late heuristic of time
Doricchi, F.; Scozia, G.; Pinto, M.; Lozito, S.; Lo Presti, S.; Pazzaglia, M.; Silvetti, M.; Lasaponara, S.
10.1101/2025.05.28.656560 — neuroscience — Posted on 2025-06-01
4450 Lysosomal stress induces amyloid-β aggregate release and reactive transformation in human astrocytes
Goldsworthy, S.; Fertan, E.; Dyal, P.; Domoney, S.; Livesey, F.; Klenerman, D.; Patani, R.; Hung, C.
10.1101/2025.05.27.656416 — neuroscience — Posted on 2025-06-01
4451 Integrin-Specific Signaling Drives ER Stress-Dependent Atherogenic Endothelial Activation
Ben Dhaou, C.; Al-Yafeai, Z.; Cruz-Marquez, G. A.; Scott, M. L.; Pearson-Gallion, B.; Cockerham, E.; Li, H.; Peretik, J. M.; Hong, Y.; Dhanesha, N.; Yurdagul, A.; Rom, O.; Bhuiyan, M. S.; Orr, A. W.
10.1101/2025.05.31.654582 — pathology — Posted on 2025-06-01
4452 Population structure of Phytophthora infestans collected from potatoes in Guatemala and Honduras
Izarra, M. L.; Perez, W. G.; Vasquez, E. F.; Perez, G. E.; Gamboa, S.; Andrade-Piedra, J.; Flores, B.; Montejo, L.; Sanders, A.; Kreuze, J. F.
10.1101/2025.05.28.656702 — pathology — Posted on 2025-06-01
4453 KODAMA enables self-guided weakly supervised learning in spatial transcriptomics
Abdel-Shafy, E. A.; Kassim, M.; Vignoli, A.; Mamdouh, F.; Tyekucheva, S.; Ahmed, D.; Ojo, D.; Price, B.; Socciarelli, F.; Duarte-Delgado, N. P.; Ocharo, M.; Okeke, C. J.; Triboli, L.; MacIntyre, D. A.; Loda, M.; Sarkar, D.; Gupta, D.; Piazza, S.; Zerbini, L. F.; Tenori, L.; Cacciatore, S.
10.1101/2025.05.28.656544 — bioinformatics — Posted on 2025-06-01
4454 The clinical drug candidate anle138b binds predominantly to the central cavity in lipidic Aβ fibrils and modulates fibril formation.
Han, M.; Frieg, B.; Matthes, D.; Leonov, A.; Ryazanov, S.; Giller, K.; Nimerovsky, E.; Stampolaki, M.; Xue, K.; Overkamp, K.; Dienemann, C.; Riedel, D.; Giese, A.; Becker, S.; de Groot, B. L.; Schroeder, G.; Andreas, L. B.; Griesinger, C.
10.1101/2025.05.30.655790 — biochemistry — Posted on 2025-06-01
4455 Genomic signatures of climate-driven (mal)adaptation in an iconic conifer, the English yew (Taxus baccata L.)
Francisco, T.; Mayol, M.; Vajana, E.; Riba, M.; Westergren, M.; Cavers, S.; Pinosio, S.; Bagnoli, F.; Marchi, M.; Aravanopoulos, F. A.; Farsakoglou, A.-M.; Scotti, I.; Fady, B.; Vendramin, G. G.; Archambeau, J.; Piotti, A.; Gonzalez-Martinez, S. C.
10.1101/2025.05.29.656833 — genomics — Posted on 2025-06-01
4456 The XPF-like domain in SHOC1 required for homologous recombination and safeguarding autosome from meiotic silencing of unsynapsed chromatin
Zhang, Y.; Sun, Q.; Ji, Z.; Mo, R.; Zhou, Y.; Zhao, J.; Xu, S.; Li, N.; Sun, Y.; Bai, H.; Zhi, E.; Han, S.; Chen, H.; Zhang, J.; Qian, D.; Bu, X.; Huang, Y.; Tian, R.; Guo, Y.; Lv, J.; Zhao, L.; Yang, C.; Zhao, F.; Li, P.; Zhou, Z.; Li, Z.; Yao, C.
10.1101/2025.05.28.656576 — developmental biology — Posted on 2025-06-01
4459 Recovery of retinal terminal fields after traumatic brain injury: evidence of collateral sprouting and sexual dimorphism
Alexandris, A. S.; Yi, J.; Liu, C.; Belamarich, J.; Alam, Z.; Vats, A.; Peng, A.; Welsbie, D. S.; Zack, D. J.; Koliatsos, V. E.
10.1101/2025.05.28.656451 — neuroscience — Posted on 2025-06-01
4462 nanoPhos enables ultra-sensitive and cell-type resolved spatialphosphoproteomics
Oliinyk, D.; Heymann, T.; Henneberg, L.; Bardziukova, A.; Thielert, M.; Kjaergaard, J.; Vasconez, S.; Oeller, M.; Rodriguez, E.; Rosenberger, F. A.; Mann, M.
10.1101/2025.05.29.656770 — systems biology — Posted on 2025-06-01
4463 Body Fluid Proteomic Landscape of Acute Exercise
Kurgan, N.; Kjaergaard, J.; Jespersen, N. Z.; Diez-Obrero, V.; Moreno-Justicia, R.; Heywood, S. E.; Lindqvist, C. B.; Ottander, L.; Samodova-Sommer, D.; Nielsen, N. S.; Durrer, C. G.; Ried-Larsen, M.; Rasmussen, S.; Loos, R. J. F.; Smit, R. A. J.; Pedersen, B. K.; Deshmukh, A. S.
10.1101/2025.05.28.656705 — physiology — Posted on 2025-06-01
4464 Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis
Grimont, A.; Falvo, D. J.; Sisso, W. J.; Zumbo, P.; Chan, C. W.; Santos, F.; Pan, G.; Cleveland, M.; Yaron, T.; Osterhoudt, A. S.; Meng, Y.; Zafra, M. P.; Fall, W. B.; Rendeiro, A. F.; Hissong, E.; Yantiss, R. K.; Betel, D.; Magnuson, M. A.; Leach, S. D.; Rustgi, A. K.; Dow, L. E.; Chandwani, R.
10.1101/2025.05.28.656689 — cancer biology — Posted on 2025-06-01
4465 Robust statistical assessment of Oncogenotype to Organotropism translation in xenografted zebrafish
Saucier, D.; Jiang, X.; Rajendran, D.; Ravishankar, R.; Butler, E.; Marchetto, A.; Kurmasheva, R.; Gruenewald, T.; Amatruda, J.; Danuser, G.
10.1101/2025.05.28.656734 — cancer biology — Posted on 2025-06-01
4466 PAMD-Ch17, a Polymeric Analog of Plerixafor, Induces Mitochondrial Dysfunction in T-ALL Cells Independent of CXCR4
Lam, C.; Dhir, A.; Jogdeo, C. M.; Panda, S.; Kapoor, E.; Tang, S.; Rivero, V.; McIntyre, E. M.; Xiao, P.; Black, A. R.; Hewitt, K.; Swenson, S. A.; Romanova, S.; Oupicky, D.; Hyde, R. K.
10.1101/2025.05.28.656643 — cancer biology — Posted on 2025-06-01
4468 Targeted suppression of SPP1 inhibits tumor invasion and metastasis in NRF2 hyperactivated cisplatin resistant HNSCC
Kawabe, M.; Yang, S.; Bolanos, L. G.; Takamatsu, S.; Flores, S. A.; Castro, P. D.; Tsai, T.-Y.; Kaga, A. N.; Frederick, M. J.; Sandulache, V.; Kadara, H.; Myers, J. N.; Osman, A. A.
10.1101/2025.05.28.656679 — cancer biology — Posted on 2025-06-01
4470 Neural Spectral Prediction for Structure Elucidation with Tandem Mass Spectrometry
Wang, R.; Manjrekar, M.; Mahjour, B.; Avila-Pacheco, J.; Provenzano, J.; Reynolds, E.; Lederbauer, M.; Mashin, E.; Goldman, S. L.; Wang, M.; Weng, J.-K.; Plata, D. L.; Clish, C. B.; Coley, C. W.
10.1101/2025.05.28.656653 — bioinformatics — Posted on 2025-06-01
4473 Controllable Gap Junctions by Vitamin B12 and Light
Cui, D.; Liu, S.; Huang, X.; Tang, X. A.; Zheng, M.; He, Z.; Xu, R.; Sun, C.; Xu, Y.; Tu, R.; Zou, P.; Xie, T.; Sun, F.
10.1101/2025.05.28.656405 — bioengineering — Posted on 2025-06-01
4477 Projected warming disrupts embryonic development and hatch timing in Antarctic fish
Streeter, M. S.; Le Francois, N. R.; Desvignes, T.; Grondin, J.; Postlethwait, J. H.; Detrich, H. W.; Daane, J.
10.1101/2025.05.28.656708 — developmental biology — Posted on 2025-06-01
4479 SUSTAINED SYSTEMIC AND NEUROINFLAMMATION IN COGNITIVE DYSFUNCTIONAL FEMALE MICE AFTER NON-SEVERE EXPERIMENTAL MALARIA
Rosa-Goncalves, P.; Siqueira-e-Silva, B. N.; Lima, M. N.; Chagas, L. d. S.; de-Sousa, L. P.; Caputo, L. F. G.; da Silva, I. J.; dos Santos, J. P. R.; Evaristo, C. C. d. A.; Nogueira, M. d. S.; Werneck, G. L.; Ribeiro-Gomes, F. L.; Totino, P. R. R.; Pratt-Riccio, L. R.; Maron-Gutierrez, T.; de Almeida, R. F.; Machado, M. P.; Serfaty, C. A.; Daniel-Ribeiro, C. T.
10.1101/2025.05.28.656400 — immunology — Posted on 2025-06-01
4480 Hair follicle stem cell fate supports distinct clinical endotypes in Hidradenitis Suppurativa
Onfroy, A.; Jean-Louis, F.; Le Corvoisier, P.; Coulpier, F.; Muret, K.; Bonnet, E.; Arrouasse, R.; Boucle, C.; Abid, S.; Sbidian, E.; Bergqvist, C.; Wolkenstein, P.; Godot, V.; Deleuze, J.-F.; Levy, Y.; Topilko, P.; Audureau, E.; Hue, S.
10.1101/2025.05.28.656362 — immunology — Posted on 2025-06-01
4481 Microtubule anchoring and coupling of CD20 to the RhoA/Rock1 pathway
Klasener, K.; Lee, C. E.; Bender, J.; Naumann, A.; Reimann, L.; Andrieux, G.; Nitschke, R.; Warscheid, B.; Warnatz, K.; Voll, R. E.; Reth, M.
10.1101/2025.05.29.656301 — immunology — Posted on 2025-06-01
4482 Germline polymorphism in the immunoglobulin kappa and lambda loci explain variation in the expressed light chain antibody repertoire
Engelbrecht, E.; Rodriguez, O. L.; Lees, W.; Vanwinkle, Z.; Shields, K.; Schultze, S.; Gibson, W. S.; Smith, D. R.; Jana, U.; Saha, S.; Peres, A.; Yaari, G.; Smith, M. L.; Watson, C. T.
10.1101/2025.05.28.656470 — immunology — Posted on 2025-06-01
4483 Effects of Natural Lithium and Lithium Isotopes on Voltage Gated Sodium Channel Activity in SH-SY5Y and IPSC Derived Cortical Neurons
Bukhteeva, I.; Livingstone, J. D.; Singh, K.; Pavlov, E. V.; Beazely, M. A.; Gingras, M. J. P.; Leonenko, Z.
10.1101/2025.05.28.656602 — neuroscience — Posted on 2025-06-01
4484 Protective role of Cannabidiol against nicotine pouch-induced seizure aggravation and alterations in brain glymphatic biomarkers.
Bhandari, B.; Naeini, S. E.; Rogers, H. M.; Alhashim, A. H.; Yu, J. C.; Seyyedi, M.; Young, N.; Salles, E. L.; Wang, L. P.; Baban, B.
10.1101/2025.05.28.656668 — neuroscience — Posted on 2025-06-01
4486 Opposing effects of H2A.Z on memory, transcription and pathology in male and female Alzheimer's disease mice and patients
Luo, J. Q.; Hategan, L. A.; Creighton, S.; Hua, S.; McLean, T. A. B.; Dahi, T. A.; Jin, Z.; Pirri, F.; Winston, S. M.; Reeves, I. L.; Fahnestock, M.; Brimble, M. A.; Walters, B. J.; Murphy, P. J.; Zovkic, I.
10.1101/2025.05.28.656659 — neuroscience — Posted on 2025-06-01
4487 Pyruvate kinase activates SARM1 to exacerbate axonal degeneration in diabetic peripheral neuropathy
Liu, J.; Li, W.; Li, C.; Jiang, Y.; Zhu, W. J.; Zhang, Z.; Zhao, Y. J.; Lin, J.; YU, W.
10.1101/2025.05.28.656718 — neuroscience — Posted on 2025-06-01
4489 Twist and Snout: Head and Body Morphologies Determine Feeding Kinematics in Substrate-Biting Fishes
Perevolotsky, T.; Brotman-Krass, J. M.; Ratner, Y.; Avigad, Y.; Summers, A. P.; Donatelli, C. M.; Holzman, R.
10.1101/2025.05.28.656629 — zoology — Posted on 2025-06-01
4490 Integrating Alternative Fragmentation Techniques into Standard LC-MS Workflows Using a Single Deep Learning Model Enhances Proteome Coverage
Levin, N.; Saylan, C. C.; Lapin, J.; Demyanenko, Y.; Yang, K. L.; Sidda, J.; Nesvizhskii, A.; Wilhelm, M.; Mohammed, S.
10.1101/2025.05.28.656555 — systems biology — Posted on 2025-06-01
4491 Maternal control of RNA decay safeguards embryo development
Del Toro-De Leon, G.; Trenti, M. S.; Vasudevan, V.; Krause, U.; Köhler, C.
10.1101/2025.05.28.656625 — plant biology — Posted on 2025-06-01
4492 Galactan mobilization during carbon starvation compromises cell wall-mediated fungal resistance in Arabidopsis
Reckleben, L.; Morton, R. N.; Munzert-Eberlein, K. S.; Thiel, S.; Rautengarten, C.; Tan, V.; Harres, K. L.; Zanoni, L.; Ebert, B.; Engelsdorf, T.
10.1101/2025.05.28.656597 — plant biology — Posted on 2025-06-01
4493 OGDHL regulates nucleotide metabolism, tumor growth, and neuroendocrine marker expression in prostate cancer
Bernard, M.; Ruiz, A.; Diaz, J.; Nunley, N.; Dove, R.; Heering, K.; Bopardikar, S.; Gallardo, A.; Hashimoto, T.; Agrawal, R.; Smith, C.; Wilde, B.; Matulionis, N.; Richards, H.; Sharifi, M.; Lang, J.; Zhao, S.; Haffner, M.; Boutros, P. C.; Christofk, H.; Goldstein, A. S.
10.1101/2025.05.28.656673 — cancer biology — Posted on 2025-06-01
4498 LazySlide: accessible and interoperable whole slide image analysis
Zheng, Y.; Abila, E.; Chrenkova, E.; Winkler, J.; Rendeiro, A. F.
10.1101/2025.05.28.656548 — bioinformatics — Posted on 2025-06-01
4499 scExploreR: a flexible platform for democratized analysis of multimodal single-cell data by non-programmers
Showers, W.; Desai, J.; Gipson, S. R.; Engel, K. L.; Smith, C.; Jordan, C. T.; Gillen, A. E.
10.1101/2025.05.28.656649 — bioinformatics — Posted on 2025-06-01
4503 Benchmarking Software for DDA-PASEF Immunopeptidomics
Chen, Y.; Preikschat, A.; Arnold, A.; Pecori, R.; Gomez-Zepeda, D.; Tenzer, S.
10.1101/2025.05.28.656277 — bioinformatics — Posted on 2025-06-01
4504 Noninvasive Control of Seizure Threshold with Acoustically Targeted Chemogenetics
Li, H.; Nouraein, S.; Lee, S.; Link, S. S.; Raisely, E. K.; Szablowski, J. O.
10.1101/2025.05.28.656723 — bioengineering — Posted on 2025-06-01
4505 The SHR/Akr Y chromosome reveals repeated turnover of the rat pseudoautosomal region
Bellott, D. W.; Skaletsky, H.; Hughes, J.; Brown, L. G.; Pyntikova, T.; Cho, T.-J.; Koutseva, N.; Zaghlul, S.; Kizghin, D.; Mendoza, M.; Raudsepp, T.; Dugan, S.; Khan, Z.; Wang, Q.; Watt, J.; Worley, K. C.; Scherer, S.; Muzny, D. M.; Gibbs, R. A.; Page, D. C.
10.1101/2025.05.28.656580 — genomics — Posted on 2025-06-01
4506 SMURF Reconstructs Single-Cells from Visium HD Data to Reveal Zonation of Transcriptional Programs in the Intestine
Guo, J.; Sarafinovska, S.; Hagenson, R.; Valentine, M.; Dougherty, J.; Mitra, R. D.; Muegge, B. D.
10.1101/2025.05.28.656357 — genomics — Posted on 2025-06-01
4509 Viruses and vectors tied to honey bee colony losses
Lamas, Z.; Rinkevich, F.; Garavito, A.; Shaulis, A.; Boncristiani, D.; Hill, E.; Chen, Y. P.; Evans, J. D.
10.1101/2025.05.28.656706 — ecology — Posted on 2025-06-01
4511 Beneficial and detrimental consequences of AHR activation in intestinal infection
Diaz, O. P.; zhou, L.; Barrington, C.; Lindquist, D.; Graelmann, F.; Wincent, E.; Stockinger, B.
10.1101/2025.05.28.656570 — immunology — Posted on 2025-06-01
4512 Mind the Gap: Does Brain Age Improve Alzheimer's Disease Prediction?
Tan, T. W. K.; Nguyen, K.-N.; Zhang, C.; Kong, R.; Cheng, S. F.; Ji, F.; Chong, J. S. X.; Chong, E. J. Y.; Venketasubramanian, N.; Orban, C.; Chee, M. W. L.; Chen, C.; Zhou, J. H.; Yeo, B. T. T.; Alzheimer's Disease Neuroimaging Initiative, ; Australian Imaging Biomarkers and Lifestyle Study of Aging,
10.1101/2024.11.16.623903 — neuroscience — Posted on 2025-06-01
4513 A Movement-Independent Signature of Urgency During Human Perceptual Decision Making
McCone, H.; Devine, C. A.; McNickle, E.; Dully, J.; Geuzebroek, A. C.; McGovern, D. P.; Kelly, S. P.; O'Connell, R. G.
10.1101/2025.05.28.656559 — neuroscience — Posted on 2025-06-01
4514 Movement sonification during haptic exploration shifts emotional outcome without altering texture perception
Mouchnino, L.; Cornuault, P.-H.; Faucheu, J.; Witt, A.; Sutter, C.; Weiland, B.; Blouin, J.; Massi, F.; Chatelet, E.; Danna, J.
10.1101/2025.05.28.656569 — neuroscience — Posted on 2025-06-01
4517 Antibiotic resistance genes detected in lichens: insights from Cladonia stellaris
Alonso-Garcia, M.; George, P. B. L.; Leclerc, S.; Veillette, M.; Duchaine, C.; Villarreal, J. C.
10.1101/2025.05.28.656581 — plant biology — Posted on 2025-06-01
4518 Stochastic gates for covariate selection in population pharmacokinetics modelling
Kekic, M.; Stepanov, O.; Wang, W.; Richardson, S.; Olabode, D.; Traynor, C.; Dearden, R.; Zhou, D.; Tang, W.; Gibbs, M.; Nowojewski, A.
10.1101/2025.05.28.656586 — pharmacology and toxicology — Posted on 2025-06-01
4519 Membrane Interfacial Potential Governs Surface Condensation and Fibrillation of α-Synuclein in Neurons
Shaikh, J.; Nagarajan, A.; Mitra, T.; Modak, A. S.; Biswas, K.; Meher, G.; Bhausaheb, A. J.; Kannan, N. A.; Sahu, B. S.; Ghatak, S.; Choubey, S.; Saleem, M.
10.1101/2025.05.30.657012 — biophysics — Posted on 2025-06-01
4520 Cell attachment and tail contraction of S. aureus phage phi812
Binovsky, J.; Siborova, M.; Novacek, J.; Bardy, P.; Baska, R.; Skubnik, K.; Botka, T.; Benesik, M.; Pantucek, R.; Tripsianes, K.; Plevka, P.
10.1101/2024.09.19.613683 — microbiology — Posted on 2025-06-01
4522 Motor impairment and adaptation in a novel non-human primate model of internal capsule infarct
Sivakumar, S. S.; Anand, S. A.; Brawer, L.; Mellor, R. L.; Burkhalter, A.; Burton, H.; Brunner, P.; Bundy, D. T.; Leuthardt, E. C.; Moran, D. W.
10.1101/2025.05.27.656471 — neuroscience — Posted on 2025-06-01
4523 Reduced susceptibility to experimentally-induced complex visual hallucinations with age
Shenyan, O.; Haye, L.; Milne, G. A.; Lisi, M.; Greenwood, J. A.; Skipper, J. I.; Dekker, T. M.
10.1101/2025.05.27.656359 — neuroscience — Posted on 2025-06-01
4525 KODA: Agentic Framework for Microbiome Drug Target Discovery
Aminian-Dehkordi, J.; Parsa, M. S.; Naghipourfar, M.; Mofrad, M.
10.1101/2025.05.27.656480 — bioinformatics — Posted on 2025-06-01
4527 Application of Spectral Domain Optical Coherence Tomography To Guide Cochlear Implant Electrode Array
Jiramongkolchai, P.; Amaral, M. M.; Paul, R.; Matt, A.; Nie, M.; Hao, S.; Adkins, A.; Liang, H.; Holden, T.; Buchman, C.; Zhou, C.
10.1101/2025.05.27.656464 — bioengineering — Posted on 2025-06-01
4530 Vascular endothelial growth factor receptors 1 and 3 mediate placental trophoblast leptin production in preeclampsia, inducing vascular dysfunction
Elgazzaz, M.; Ogbi, S.; Moronge, D.; Mellott, E.; Cooper, G.; Backer, K.; Hitchings, J.; Zarate, L. V.; Kavuri, S.; Lee, T. J.; Ilatovskaya, D.; Woodham, P. C.; Maher, J.; Annex, B. H.; Faulkner, J. L.
10.1101/2025.05.27.656489 — physiology — Posted on 2025-06-01
4532 Rules of engagement: determinants of chemokine receptor activation and selectivity by CCL27 and CCL28
Huang, M.; Celniker, A. F.; Chitsazi, R.; Dyer, D. P.; Jansma, A. L.; Kufareva, I.; Salanga, C. L.; Handel, T.
10.1101/2025.05.27.656466 — pharmacology and toxicology — Posted on 2025-06-01
4533 In-Silico Characterization of TP53 Splice Mutations in Somatic and Germline Tumours
Bhandarkar, A. A.; Kelly-Foleni, N. E.; Sarkar, D.; Jeffs, A.; Slatter, T.; Braithwaite, A.; Mehta, S.
10.1101/2025.05.27.656522 — cancer biology — Posted on 2025-06-01
4534 Engineering Sustained-Release Broadly Neutralizing Antibody Formulations
Jons, C. K.; Kasse, C. M.; Mayer, B. T.; Hyrien, O.; Sen, S.; Meany, E. L.; d'Aquino, A. I.; Ganesh, P.; Eckman, N.; Dong, C.; Yan, J.; Nguyen, L. T.; Doulames, V. M.; Song, Y. E.; Saouaf, O. M.; Williams, C. M.; Williams, S. C.; Paredes, J.; Raghavan, R.; Palomares, M.; Alpert, M.; Yates, N. L.; Tomaras, G.; Seaman, M. S.; Farzan, M.; Appel, E. A.
10.1101/2025.05.27.656504 — bioengineering — Posted on 2025-06-01
4535 Female cortical cellular mosaicism underlies shared MeCP2 and PCB impacted gene pathways
Sharifi, O.; Neier, K. E.; Valenzuela, A. E.; Torres, C. G.; Korf, I.; Lein, P. J.; Yasui, D. H.; LaSalle, J.
10.1101/2025.05.28.655836 — systems biology — Posted on 2025-06-01
4537 Ketogenesis is dispensable for the metabolic adaptations to caloric restriction
Yeh, C.-Y.; Borgelt, L.; Vogt, B. J.; Clark, A. A.; Wong, T. T.; Grunow, I.; Sonsalla, M. M.; Babygirija, R.; Liu, Y.; Trautman, M. E.; Calubag, M. F.; Knopf, B. A.; Xiao, F.; Lamming, D.
10.1101/2025.05.29.656153 — physiology — Posted on 2025-06-01
4538 Multiscale Modeling Uncovers Macrophage Infiltration and TNF-α Signaling Networks for Targeting in Inflammatory Breast Cancer Tumor Emboli
PAI, P.; Van Berckelaer, C.; Van Laere, S.; Bennion, A.; Charity, T.; Yang, J.; Bertucci, F.; Van Dam, P.; Palmer, G. M.; McCall, S.; Dirix, L. Y.; Ueno, N. T.; Devi, G.
10.1101/2025.05.29.656249 — cancer biology — Posted on 2025-06-01
4539 Inter-tool analysis of a NIST dataset for assessing baseline nucleic acid sequence screening
Laird, T. S.; Flyangolts, K.; Bartling, C.; Gemler, B. T.; Beal, J.; Mitchell, T.; Murphy, S. T.; Berlips, J.; Foner, L.; Doughty, R.; Quintana, F.; Nute, M.; Treangen, T. J.; Godbold, G.; Ternus, K.; Alexanian, T.; Wheeler, N.; Forry, S. P.
10.1101/2025.05.30.655379 — bioinformatics — Posted on 2025-06-01
4541 Visualizing the Chronicle of Multiple Cell Fate using a Near-IR Dual-RNA/DNA-Targeting Probe
Sutrisno, L.; Richards, G. J.; Evans, J. D.; Matsumoto, M.; Li, X.; Uto, K.; Hill, J. P.; Taki, M.; Yamaguchi, S.; Ariga, K.
10.1101/2025.05.29.655717 — bioengineering — Posted on 2025-06-01
4545 The Kocurious case of Noodlococcus: genomic insights into Kocuria rhizophila from characterisation of a laboratory contaminant
McCallum, G. E.; Ho, S. F. S.; Cummins, E. A.; Wildsmith, A. J.; McInnes, R. S.; Weigel, C.; Tong, L. Y. S.; Quick, J.; van Schaik, W.; Moran, R. A.
10.1101/2025.05.28.656266 — genomics — Posted on 2025-06-01
4547 KLHL41 orchestrates sarcomere assembly and size to drive skeletal muscle hypertrophy in vivo
Han, H.; Shi, J.; Bongiorno, A. H.; Mansur, A.; Widrick, J.; Tate, G.; Gill, S.; Karimi, E.; Granzier, H.; Moore, J. R.; Gupta, V. A.
10.1101/2025.05.30.655367 — genetics — Posted on 2025-06-01
4548 A primate model organism for cardiac arrhythmias identifies a magnesium transporter in pacemaker function
Chang, S.; Karanewsky, C. J.; Pendleton, J. L.; Ren, L.; Anzeraey, A.; Froelicher, V.; Liang, D.; Razafindrakoto, A.; Ravelonjanahary, H. N.; Albertelli, M. A.; Quertermous, T.; Wright, P. C.; Perret, M.; Terrien, J.; Aujard, F.; Wu, J. C.; Krasnow, M. A.
10.1101/2025.05.28.655959 — genetics — Posted on 2025-06-01
4550 Rational design of respiratory syncytial virus dimeric F-subunit vaccines in protein and mRNA forms
Li, J.; Ma, X.; Xu, Z.; Guo, W.; Peng, R.; zhang, Y.; Meng, Y.; Wang, Q.; Li, S.; Chen, J.; Guo, Y.; Lu, X.; Wang, Q.; Guo, Y.; Jia, M.-a.; Li, Y.; Zhang, Y.; Li, S.; Du, P.; Wang, Q.; Gao, G. F.; Qi, J.
10.1101/2025.05.31.655981 — immunology — Posted on 2025-06-01
4551 Characterising Structural Brain Connectivity of Patients with First Episode of Psychosis
Sanchez, S. M.; Knösche, T.; Fürstova, P.; Skoch, A.; Spaniel, F.; Schmidt, H.; Hlinka, J.
10.1101/2025.05.30.656096 — neuroscience — Posted on 2025-06-01
4552 Dexmedetomidine produces more sleep-like brain activity compared to propofol
Krause, B. M.; Dappen, E. R.; Mueller, R. N.; Kawasaki, H.; Sanders, R. D.; Nourski, K. V.; Banks, M. I.
10.1101/2025.05.27.656383 — neuroscience — Posted on 2025-06-01
4553 Four-dimensional neural space for moral inference
Chen, J.; Santavirta, S.; Putkinen, V. J.; Boggio, P.; Nummenmaa, L.
10.1101/2025.05.28.656268 — neuroscience — Posted on 2025-06-01
4555 An atlas of TF driven gene programs across human cells
Pett, J. P.; Prete, M.; Pham, D.; England, N.; Yuan, H.; Prigmore, E.; Tuck, L.; Oszlanczi, A.; To, K.; Xu, C.; Suo, C.; Dann, E.; He, P.; Kedlian, V. R.; Kanemaru, K.; Cranley, J.; Yang, L.; Elmentaite, R.; Oliver, A. J.; Cujba, A.-M.; Cakir, B.; Murray, S.; Mahbubani, K. T.; Saeb-Parsy, K.; Gambardella, L.; Kasper, M.; Haniffa, M. A.; Nawijn, M. C.; Teichmann, S. A.; Meyer, K. B.
10.1101/2025.05.30.657075 — genetics — Posted on 2025-06-01
4556 Making new connections: An fNIRS machine learning classification study of neural synchrony in the default mode network
Miao, G. Q.; Lieberman, I. J.; Binnquist, A. L.; Pluta, A.; Goldstein, B. M.; Dale, R.; Lieberman, M. D.
10.1101/2025.05.31.656874 — neuroscience — Posted on 2025-06-01
4557 Encoding of speech modes and loudness in ventral precentral gyrus
Srinivasan, A.; Wairagkar, M.; Iacobacci, C.; Hou, X.; Card, N. S.; Jacques, B. G.; Pritchard, A. L.; Bechefsky, P. H.; Hochberg, L. R.; AuYong, N.; Pandarinath, C.; Brandman, D. M.; Stavisky, S. D.
10.1101/2025.05.30.657105 — neuroscience — Posted on 2025-06-01
4558 From Morphology to Computation: How Synaptic Organization Shapes Place Fields in CA1 Pyramidal Neurons
Tasciotti, S.; Iascone, D. M.; Chavlis, S.; Hammond, L.; Katz, Y.; Losonczy, A.; Polleaux, F.; Poirazi, P.
10.1101/2025.05.30.657022 — neuroscience — Posted on 2025-06-01
4559 Pupil responses to social stimuli are associated with adaptive behaviors across the first 24 months of life
Grzadzinski, R.; Carpenter, R. S.; Rutshon, J.; Jatkar, A.; Mata, K.; Bhatt, A.; Ortiz-Juza, M. M.; Dennehey, M. R.; Gilleskie, D. B.; Ellison, J.; Pegard, N.; Rodriguez-Romaguera, J.
10.1101/2025.05.30.656675 — physiology — Posted on 2025-06-01
4560 Cell-type-specific patterns and consequences of somatic mutation in development and aging brain
Kriz, A. J.; Mao, S.; Shao, D. D.; Snellings, D. A.; Andersen, R.; Dong, G.; Ma, C. C.; Cline, H. E.; Huang, A. Y.; Lee, E. A.; Walsh, C. A.
10.1101/2025.05.30.656844 — genomics — Posted on 2025-06-01
4561 Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model
Yokomizo, S.; Maci, M.; Stafford, A. M.; Miller, M. R.; Perle, S. J.; Takahashi, S.; Brown-Harding, H.; Liang, L.; Lovely, A.; Algamal, M.; Gillani, R. L.; Zwang, T. J.; Richardson, D.; Naegele, J. R.; Vogt, D.; Kastanenka, K. V.
10.1101/2025.05.31.656412 — neuroscience — Posted on 2025-06-01
4562 The mGluR5 Agonist, CHPG, Enhances Numbers of Differentiated Human Oligodendrocytes
Huang, Y.; Geywitz, C.; Bandaru, A.; Glass, I.; Birth Defects Research Laboratory, ; Schirmer, L.; Nobuta, H.; Dreyfus, C.
10.1101/2025.05.31.656838 — neuroscience — Posted on 2025-06-01