Channel:  Francis Crick Institute

1,153 Articles

Applying high-resolution spatial transcriptomics to characterise the amyloid plaque cell niche in Alzheimer's Disease
Mallach, A., Zielonka, M., van Lieshout, V., An, Y., Khoo, J. H., Vanheusden, M., Chen, W.-T., Moechars, D., Arancibia-Carcamo, I. L., Fiers, M., De Strooper, B.
10.1101/2023.06.29.546675 — Posted: 2023-07-01
A chromatinized origin reduces the mobility of ORC and MCM through interactions and spatial constraint
Sanchez, H., Liu, Z., van Veen, E., van Laar, T., Solano, B., Diffley, J. F. X., Dekker, N. H.
10.1101/2023.05.18.541303 — Posted: 2023-06-30
Two-color coincidence single-molecule pull-down for the specific detection of disease-associated protein aggregates
Saleeb, R. S., Leighton, C., Lee, J.-E., O'Shaughnessy, J., Jeacock, K., Chappard, A., Cumberland, R., Ball, S. R., Sunde, M., Clarke, D. J., Piche, K., McPhail, J. A., Louwrier, A., Angers, R., Gandhi, S., Downey, P., Kunath, T., Horrocks, M. H.
10.1101/2023.06.27.546642 — Posted: 2023-06-29
Comparative analysis of N-terminal cysteine dioxygenation and prolyl-hydroxylation as oxygen sensing pathways in mammalian cells
Tian, Y.-M., Holdship, P., To, T. Q., Ratcliffe, P. J., Keeley, T. P.
10.1101/2023.06.25.545688 — Posted: 2023-06-26
p97/VCP targets Toxoplasma gondii vacuoles for parasite restriction in interferon-stimulated human cells
Clough, B., Fisch, D., Mize, T. H., Encheva, V., Snijders, A., Frickel, E.
10.1101/2023.06.20.545566 — Posted: 2023-06-23
Abundant capped RNAs are derived from mRNA cleavage at 3'UTR G-Quadruplexes
Haberman, N., Digby, H., Faraway, R., Cheung, R., Jobbins, A. M., Parr, C., Yasuzawa, K., Kasukawa, T., Yip, C. W., Kato, M., Takahashi, H., Carninci, P., Vernia, S., Ule, J., Sibley, C. R., Martinez-Sanchez, A., Lenhard, B.
10.1101/2023.04.27.538568 — Posted: 2023-06-22
Dynamic X-chromosomal reactivation enhances female brain resilience
Kaeseberg, S., Bertin, M., Menon, R., Gabassi, E., Todorov, H., Frank, S., Brennenstuhl, H., Lohrer, B., Winter, J., Krummeich, J., Winkler, J., Winner, B., Weis, E., Hartwich, D., Diederich, S., Luck, K., Gerber, S., Lunt, P., Berninger, B., Falk, S., Schweiger, S., Karow, M.
10.1101/2023.06.17.545424 — Posted: 2023-06-21
Wireless monitoring of respiration with EEG reveals relationships between respiration, behaviour and brain activity in freely moving mice
Dasgupta, D., Schneider-Luftman, D., Schaefer, A., Harris, J. J.
10.1101/2023.06.19.544346 — Posted: 2023-06-21
Structure-guided design and optimization of covalent VHL-targeted sulfonyl fluoride PROTACs
Shah, R. R., De Vita, E., Conole, D., Sathyamurthi, P. S., Zhang, X., Fellows, E., Fleites, C. M., Queisser, M. A., Harling, J. D., Tate, E. W.
10.1101/2023.06.20.545773 — Posted: 2023-06-20
The T766M-EGFR lung cancer mutation promotes tumor growth by exploiting newfound assembly mechanisms in ligand-free EGFR oligomers
Iyer, R. S., Needham, S. R., Galdadas, I., Davis, B. M., Roberts, S. K., Man, R. C., Zanetti-Domingues, L. C., Clarke, D. T., Fruhwirth, G. O., Parker, P. J., Rolfe, D. J., Gervasio, F. L., Martin-Fernandez, M. L.
10.1101/2023.06.16.545259 — Posted: 2023-06-20

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