Channel:  Babraham Institute

157 Articles

Protein degradation shapes developmental tempo in mouse and human neural progenitors
Nakanoh, S., Stamataki, D., Garcia-Perez, L., Azzi, C., Carr, H. L., Pokhilko, A., Doshi, L., Boezio, G. L. M., Melchionda, M., Howell, S., Yu, L., Skehel, M., Oxley, D., Andrews, S., Briscoe, J., Rayon, T.
10.1101/2024.08.01.604391 — Posted: 2025-09-27
A post-transcriptional regulatory checkpoint controls the response of tumor-infiltrating cytotoxic CD4+ T cells to immunotherapy
Vila de Mucha, M., Hlond, J., Costoya, C., Lau, C.-I., Sledzinska, A., Uddin, I., Navarrete, M., Shah, M., Mastrokalos, G., Karagianni, D., Bell, S. E., Nattress, C., Beattie, G., Tape, C. J., Turner, M., Quezada, S. A., Jenner, R. G.
10.1101/2025.09.09.675154 — Posted: 2025-09-12
Pervanadate-induced oxidation relieves autoinhibition of SRC protein tyrosine kinase
Mulholland, K. E., Bourguet, M., Cheng, N., Rahman, O., Ezerina, D., Daly, L. A., Lai, T., Casanova, S. A., Creixell, P., Eyers, C., Eyers, P., Messens, J., Byrne, D., Sharpe, H.
10.1101/2025.04.27.650842 — Posted: 2025-06-12
TrAEL-seq captures DNA replication dynamics in mammalian cells
Kara, N., Biggins, L., Grinkevich, V., Whale, A., Garran Garcia, P., Srinivasan, J., Rugg-Gunn, P., Andrews, S., Parry, A., Robinson, H. M. R., Houseley, J.
10.1101/2025.06.09.658559 — Posted: 2025-06-11
Re-engineering of acetyl coenzyme A metabolism prevents senescence in budding yeast
Hadj-Moussa, H., Ulusan, M., Horkai, D., Mirza, M. K. A., Houseley, J.
10.1101/2025.03.27.645766 — Posted: 2025-03-27
RNA helicase DDX1 regulates germinal centre selection and affinity maturation by promoting tRNA ligase activity
Kimber, R., Ingelsfield, S., Screen, M., Salerno, F., Matheson, L. S., Okkenhaug, H., Whale, A., Assalaarachchi, J., Stammers, M., Akdeniz, D., Andrews, S., Ribeiro de Almeida, C.
10.1101/2025.01.10.632317 — Posted: 2025-01-14
H3.1K27M-induced misregulation of the TSK/TONSL-H3.1 pathway causes genomic instability
Yuan, W., Huang, Y.-C., LeBlanc, C., Poulet, A., Valsakumar, D., van Wolfswinkel, J. C., Voigt, P., Jacob, Y.
10.1101/2024.12.09.627617 — Posted: 2024-12-11
RNA-binding proteins control the G2-M checkpoint of the germinal centre B cell
Salerno, F., Whale, A., Matheson, L. S., Foster, W., Stammers, M., Bell, S. E., Hidson, D. J., Linterman, M. A., Houseley, J. A., Turner, M.
10.1101/2024.12.01.626220 — Posted: 2024-12-05
p110alpha-dependent hepatocyte signaling is critical for liver gene expression and its rewiring in MASLD
Regnier, M., Polizzi, A., Fougeray, T., Fougerat, A., Perrier, P., Anderson, K., Lippi, Y., Smati, S., Lukowicz, C., Lasserre, F., Fouche, E., Huillet, M., Rives, C., Tramunt, B., Naylies, C., Garcia, G., Rousseau-Bacquie, E., Bertrand-Michel, J., Canlet, C., Chevolleau-Mege, S., Debrauwer, L., Heymes, C., Burcelin, R., Levade, T., Gourdy, P., Wahli, W., Blum, Y., Gamet-Payrastre, L., Ellero-Simatos, S., Guillermet-Guibert, J., Hawkins, P., Stephens, L., Postic, C., Montagner, A., Loiseau, N., Guillou, H.
10.1101/2024.01.09.574858 — Posted: 2024-10-31
KRAS G12 mutant alleles differentially control glutamine metabolism via FOXO1
Ber, S., Yang, M., Sciacovelli, M., Samarajiwa, S., Patel, K., Nikitopoulou, E., Howitt, A., Cook, S. J., Venkitaraman, A. R., Frezza, C., Esposito, A.
10.1101/2024.10.19.618135 — Posted: 2024-10-22

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