COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

30,796 Articles (22,527 medRxiv, 8,269 bioRxiv)

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Specific mutations in SARS-CoV2 RNA dependent RNA polymerase and helicase alter protein structure, dynamics and thus function: Effect on viral RNA replication
Begum, F., MUKHERJEE, D., DAS, S., THAGRIKI, D., TRIPATHI, P. P., BANERJEE, A. K., RAY, U.
10.1101/2020.04.26.063024 — Posted: 2020-04-27
Coronavirus, as a source of pandemic pathogens.
Konishi, T.
10.1101/2020.04.26.063032 — Posted: 2020-04-27
Emergence of multiple variants of SARS-CoV-2 with signature structural changes
Bhowmik, D., Pal, S., Lahiri, A., Talukdar, A., Paul, S.
10.1101/2020.04.26.062471 — Posted: 2020-04-27
Role of 1'-Ribose Cyano Substitution for Remdesivir to Effectively Inhibit both Nucleotide Addition and Proofreading in SARS-CoV-2 Viral RNA Replication
Zhang, L., Zhang, D., Yuan, C., Wang, X., Li, Y., Jia, X., Gao, X., Yen, H.-L., Cheung, P., Huang, X.
10.1101/2020.04.27.063859 — Posted: 2020-04-27 Discussion: Onsite
Disparate temperature-dependent virus - host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium
V'kovski, P., Steiner, S., Gultom, M., Kelly, J. N., Russeil, J., Mangeat, B., Cora, E., Pezoldt, J., Holwerda, M., Kratzel, A., Laloli, L., Wider, M., Portmann, J., Thao, T. T. N., Ebert, N., Stalder, H., Hartmann, R., Gardeux, V., Alpern, D., Deplancke, B., Thiel, V., Dijkman, R.
10.1101/2020.04.27.062315 — Posted: 2020-04-27 Discussion: Onsite
Structure of replicating SARS-CoV-2 polymerase
Hillen, H. S., Kokic, G., Farnung, L., Dienemann, C., Tegunov, D., Cramer, P.
10.1101/2020.04.27.063180 — Posted: 2020-04-27
Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice.
Pruijssers, A. J., George, A. S., Schäfer, A., Leist, S. R., Gralinski, L. E., Dinnon, K. H., Yount, B. L., Agostini, M. L., Stevens, L. J., Chappell, J. D., Lu, X., Hughes, T. M., Gully, K. L., Martinez, D. R., Brown, A. J., Graham, R. L., Perry, J. K., Du Pont, V., Pitts, J., Ma, B., Babusis, D., Murakami, E., Feng, J. Y., Bilello, J. P., Porter, D. P., Cihlar, T., Baric, R. S., Denison, M. R., Sheahan, T. P.
10.1101/2020.04.27.064279 — Posted: 2020-04-27 Discussion: Onsite
A SARS-CoV-2 vaccine candidate would likely match all currently circulating strains
Dearlove, B. L., Lewitus, E., Bai, H., Li, Y., Reeves, D. B., Joyce, M. G., Scott, P., Amare, M., Vasan, S., Michael, N. L., Modjarrad, K., Rolland, M.
10.1101/2020.04.27.064774 — Posted: 2020-04-27
SARS-CoV-2 On-the-Spot Virus Detection Directly From Patients
Ben-Assa, N., Naddaf, R., Gefen, T., Capucha, T., Hajjo, H., Mandelbaum, N., Elbaum, L., Rogov, P., King, D. A., Kaplan, S., Rotem, A., Chowers, M., Szwarcwort-Cohen, M., Paul, M., Geva-Zatorsky, N.
10.1101/2020.04.22.20072389 — Posted: 2020-04-27 Discussion: Onsite
Cytotoxicity evaluation of chloroquine and hydroxychloroquine in multiple cell lines and tissues by dynamic imaging system and PBPK model
Yang, J., Wu, M., Liu, X., Liu, Q., Guo, Z., Yao, X., Liu, Y., Cui, C., Li, H., Song, C., Liu, D., Xue, L.
10.1101/2020.04.22.056762 — Posted: 2020-04-27 Discussion: Offsite

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Subject Areas
* The Clinical Trials and Epidemiology subject categories are now closed to new submissions following the completion of bioRxiv's clinical research pilot project and launch of the dedicated health sciences server medRxiv (submit.medrxiv.org). New papers that report results of Clinical Trials must now be submitted to medRxiv. Most new Epidemiology papers also should be submitted to medRxiv, but if a paper contains no health-related information, authors may choose to submit it to another bioRxiv subject category (e.g., Genetics or Microbiology).