COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

31,430 Articles (22,835 medRxiv, 8,595 bioRxiv)

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Structural basis for broad sarbecovirus neutralization by a human monoclonal antibody
Tortorici, M. A., Czudnochowski, N., Starr, T. N., Marzi, R., Walls, A. C., Zatta, F., Bowen, J. E., Jaconi, S., di Iulio, J., Wang, Z., De Marco, A., Zepeda, S., Pinto, D., Liu, Z., Beltramello, M., Bartha, I., Housley, M. P., Lempp, F. A., Rosen, L. E., Dellota, E., Kaiser, H., Montiel-Ruiz, M., Zhou, J., Addetia, A., Guarino, B., Culap, K., Sprugasci, N., Saliba, C., Vetti, E., Giacchetto-Sasselli, I., Silacci Fregni, C., Abdelnabi, R., Foo, C. S.-Y., Havenar-Daughton, C., Schmid, M. A., Benigni, F., Cameroni, E., Neyts, J., Telenti, A., Snell, G., Virgin, H. W., Whelan, S. P. J., Bloom, J. D., Corti, D., Veesler, D., Pizzuto, M. S.
10.1101/2021.04.07.438818 — Posted: 2021-04-08
TMPRSS2 and RNA-dependent RNA polymerase are effective targets of therapeutic intervention for treatment of COVID-19 caused by SARS-CoV-2 variants (B.1.1.7 and B.1.351)
Lee, J., Lee, J., Kim, H. J., Ko, M., Jee, Y., Kim, S.
10.1101/2021.04.06.438540 — Posted: 2021-04-08
Synthetic repertoires derived from convalescent COVID-19 patients enable discovery of SARS-CoV-2 neutralizing antibodies and a novel quaternary binding modality
Gollihar, J. D., McLellan, J. S., Boutz, D. R., Goike, J., Horton, A., Gardner, E. C., Bartzoka, F., Wang, N., Javanmardi, K., Herbert, A., Abbasi, S., Renberg, R., Johanson, M. J., Cardona, J. A., Segall-Shapiro, T., Zhou, L., Nissly, R. H., Gontu, A., Byrom, M., Maranhao, A. C., Battenhouse, A. M., Gejji, V., Soto-Sierra, L., Foster, E. R., Woodard, S. L., Nikolov, Z. L., Lavinder, J., Voss, W. N., Annapareddy, A., Ippolito, G. C., Ellington, A. D., Marcotte, E. M., Finkelstein, I. J., Hughes, R. A., Musser, J. M., Kuchipudi, S. V., Kapur, V., Georgiou, G., Dye, J. M.
10.1101/2021.04.07.438849 — Posted: 2021-04-08
Identification of SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of the nsp14 RNA Cap Methyltransferase
Basier, C., Basu, S., Beale, R., Canal, B., Cowling, V. H., Curran, J. F., Deegan, T. D., Diffley, J. F., Drury, L. S., Fujisawa, R., Howell, M., Labib, K., Lim, C. T., Mak, T., McClure, A. W., Roberts, E., Tan, K. W., Ulferts, R., Weissmann, F., Wu, M., Zeisner, T. U.
10.1101/2021.04.07.438810 — Posted: 2021-04-08
Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp14/nsp10 Exoribonuclease
Basier, C., Basu, S., Beale, R., Bertolin, A. P., Canal, B., Curran, J. F., Deegan, T. D., Diffley, J. F., Drury, L. S., Fujisawa, R., Howell, M., Labib, K., McClure, A. W., Milligan, J., Roberts, E., Ulferts, R., Weissmann, F., Wu, M., Zeng, J.
10.1101/2021.04.07.438812 — Posted: 2021-04-08
Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp15 Endoribonuclease
Beale, R., Bertolin, A. P., Canal, B., Deegan, T. D., Diffley, J. F., Drury, L. S., Fujisawa, R., Howell, M., Labib, K., McClure, A. W., Ulferts, R., Weissmann, F., Wu, M., Zeng, J.
10.1101/2021.04.07.438811 — Posted: 2021-04-08
Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp3 Papain-like Protease
Armstrong, L. A., Beale, R., Bineva-Todd, G., Canal, B., Diffley, J. F., Drury, L. S., Howell, M., Kulathu, Y., Labib, K., Lim, C. T., Milligan, J., O'Reilly, N., Ozono, E., Tan, K. W., Ulferts, R., Weissmann, F., Wu, M., Zeisner, T. U., Zeng, J.
10.1101/2021.04.07.438804 — Posted: 2021-04-08
Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp13 Helicase
Beale, R., Bertolin, A. P., Borg, A., Canal, B., Diffley, J. F., Drury, L. S., Harvey, R., Howell, M., Hussain, S., Kjaer, S., McCauley, J., McCoy, L., Milligan, J., Posse, V., Roustan, C., Ulferts, R., Weissmann, F., Wu, M., Zeng, J.
10.1101/2021.04.07.438808 — Posted: 2021-04-08
Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp12/7/8 RNA-dependent RNA Polymerase
Beale, R., Bertolin, A. P., Canal, B., Diffley, J. F., Drury, L. S., Howell, M., Milligan, J., Posse, V., Ulferts, R., Weissmann, F., Wu, M., Zeng, J.
10.1101/2021.04.07.438807 — Posted: 2021-04-08
Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of nsp5 Main Protease
Basier, C., Beale, R., Bineva-Todd, G., Canal, B., Curran, J. F., Deegan, T. D., Diffley, J. F., Fujisawa, R., Howell, M., Joshi, D., Labib, K., Lim, C. T., Milligan, J., Nagaraj, H., O'Reilly, N., Papageorgiou, G., Soudy, C., Tan, K. W., Ulferts, R., Weissmann, F., Wu, M., Zeisner, T. U.
10.1101/2021.04.07.438806 — Posted: 2021-04-08

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* The Clinical Trials and Epidemiology subject categories are now closed to new submissions following the completion of bioRxiv's clinical research pilot project and launch of the dedicated health sciences server medRxiv (submit.medrxiv.org). New papers that report results of Clinical Trials must now be submitted to medRxiv. Most new Epidemiology papers also should be submitted to medRxiv, but if a paper contains no health-related information, authors may choose to submit it to another bioRxiv subject category (e.g., Genetics or Microbiology).