COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

31,652 Articles (22,913 medRxiv, 8,739 bioRxiv)

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Variant emergence, not vaccine deployment, drives episodic positive selection on the SARS-CoV-2 spike at provincial scale in Canada
Tomas, M., Ndongo, C. P. K., Vilain, M., Aris-Brosou, S.
10.64898/2026.05.16.725625 — Posted: 2026-05-19
Orally Bioavailable SARS-CoV-2 Protease Inhibitors Bearing a Hydroxymethyl Ketone Warhead
Elshan, N. G. R. D., Wolff, K. C., Weiss, F., Ghorai, S., Grabovyi, G., Wilson, K., Riva, L., Woods, A. K., Pedroarena, J., Nazarian, A., Liu, Y., Mazumdar, W., Song, L., Okwor, N., Malvin, J., Bakowski, M. A., Kirkpatrick, M. G., Gebara-Lamb, A., Huang, E., Nguyen-Tran, V. T. B., Chi, V., Li, S., Lee, K.-J., McNamara, C. W., Gupta, A. K., Rahimi, A., Chen, J. J., Joseph, S. B., Schultz, P. G., Chatterjee, A. K.
10.64898/2026.05.15.725542 — Posted: 2026-05-18
Environmental stochasticity can account for patterns of within-host respiratory virus evolution
Xiao, W. F., Farjo, M. N., Lowen, A. C., Koelle, K.
10.64898/2026.05.15.725410 — Posted: 2026-05-18
Who infected the reported cases? Evidence from 678,482 COVID-19 cases with identified infector collected in routine surveillance in the Netherlands, 2020-2022.
Backer, J. A., Leung, K. Y., Andeweg, S. P., Van de Kassteele, J., Veldhuijzen, I., Hahne, S., Wallinga, J.
10.64898/2026.05.15.26347859 — Posted: 2026-05-17
Expansion Revealing of Pathology Resolves Nanostructures Associated with Inflammatory Phenotypes in COVID-19 Decedent Human Brain Tissue
Stanton, A. E., Kang, J., Blanchard, J. W., Boix, C. A., Schroeder, M. E., Lee, Y., Su, H., Wang, S., Yu, E., Emenari, A., Peng, Z., Agbas, E., Cerit, O., Park, D., Zhang, R., Bennett, D. A., Yin, P., Kellis, M., Langer, R., Boyden, E., Tsai, L.-H.
10.64898/2026.05.14.725177 — Posted: 2026-05-15
A Structural Domain in the genomic RNA of SARS-CoV-2 Folds into a Compact Granular Structure without the N protein: A Single-Molecule Fluorescence Spectroscopic Investigation
Kimura, T., Katayama, T., Ishikawa, S., Mitra, S., Yamano, Y., Onizuka, K., Nagatsugi, F., Laha, S., Naganathan, A. N., Itoh, Y., Takahashi, S.
10.64898/2026.05.15.725307 — Posted: 2026-05-15
Immunological imprinting shapes the cross-reactive antibody responses to the KP.2 and LP.8.1 vaccine doses
Kumar, S., Lai, L., Ellis, M., Patel, A. B., Joshi, D. J., Velden, J. V., Faraj, J. Z. A., Wimalasena, S. T., Pallavi, R. R., Iriss, J., Bechnak, K., Edupuganti, S., Rouphael, N., Ortlund, E., Moreno, A., Menachery, V. D., Zarnitsyna, V. I., Wrammert, J., Suthar, M. S.
10.64898/2026.05.13.725047 — Posted: 2026-05-15
Transcranial direct current stimulation-augmented cognitive training for post-COVID-19 cognition: A phase IIb randomized controlled trial
Trujillo Llano, C., Fromm, A. E., Lingemann, L., Grittner, U., Meinzer, M. F., Fleischmann, R., Brakemeier, E.-L., Antonenko, D. F., Floeel, A.
10.64898/2026.05.11.26352906 — Posted: 2026-05-14
Pathogen-specific host responses define distinct pneumonia endotypes in the human lung
Markov, N. S., Mozejko, M., Guggilla, V., Łazecka, M., Donnelly, H. K., Donayre, A., Fenske, S., Peltekian, A., Puczko-Szymanski, B., Szymczak, P., Izdebski, A., Luo, L., Senkow, K. J., Cusick, L., Yu, Z., Swaminathan, S., Lu, Z., Abdala-Valencia, H., Phan, D., Clepp, R. K., Rasmussen, L. V., Pawlowski, A., Pickens, C. O., Nadig, N. R., Walunas, T., Tighe, R., The Neu-Lung Investigators, , Wunderink, R. G., Budinger, G. S., Morales-Nebreda, L., Gao, C. A., Singer, B. D., Misharin, A. V., Szczurek, E., The NU SCRIPT Study Investigators
10.64898/2026.05.12.724509 — Posted: 2026-05-14
Recovery of proofreading-impaired SARS-CoV-2 reveals a mutator phenotype and an ExoN activity threshold for viability
He, L., Su, Y.-W. N., Zhang, F., Moustafa Abdelrady, I., Gohara, D. W., Ye, C., Martinez-Sobrido, L., Arnold, J. J., Cameron, C. E., Xiang, Y.
10.64898/2026.05.12.724615 — Posted: 2026-05-12

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* The Clinical Trials and Epidemiology subject categories are now closed to new submissions following the completion of bioRxiv's clinical research pilot project and launch of the dedicated health sciences server medRxiv (submit.medrxiv.org). New papers that report results of Clinical Trials must now be submitted to medRxiv. Most new Epidemiology papers also should be submitted to medRxiv, but if a paper contains no health-related information, authors may choose to submit it to another bioRxiv subject category (e.g., Genetics or Microbiology).