COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

30,899 Articles (22,568 medRxiv, 8,331 bioRxiv)

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SARS-CoV-2 proteases cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species and the search for reservoir hosts.
Moustaqil, M., Ollivier, E., Chiu, H.-P., Rudolffi-Soto, P., Van Tol, S., Stevens, C., Bhumkar, A., Hunter, D. J. B., Freiberg, A. N., Jacques, D., Lee, B., Sierecki, E., Gambin, Y.
10.1101/2020.06.05.135699 — Posted: 2020-06-05 Discussion: Offsite
SARS-CoV-2 infection leads to acute infection with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species
Singh, D. K., Ganatra, S. R., Singh, B., Cole, J., Alfson, K. J., Clemmons, E., Gazi, M., Gonzalez, O., Escabedo, R., Lee, T.-H., Chatterjee, A., Goez-Gazi, Y., Sharan, R., Thippeshappa, R., Gough, M., Alvarez, C., Blakely, A., Ferdin, J., Bartley, C., Staples, H., Parodi, L., Callery, J., Mannino, A., Klaffke, B., Escareno, P., Platt, R. N., Hodara, V., Scordo, J., Oyejide, A., Ajithdoss, D. K., Copin, R., Baum, A., Kyratsous, C., Alvarez, X., Rosa, B., Ahmed, M., Goodroe, A., Dutton, J., Hall-Ursone, S., Frost, P., Voges, A. K., Ross, C. N., Sayers, K., Chen, C., Hallam, C., Khader, S. A., Mitreva, M., Anderson, T., Martinez-Sobrido, L., Patterson, J., Turner, J., Torrelles, J. B., Dick, E. J., Brasky, K., Schlesinger, L. S., Giavedoni, L., Kaushal, D., Carrion, R.
10.1101/2020.06.05.136481 — Posted: 2020-06-05 Discussion: Onsite | Offsite
SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface
Bertoglio, F., Meier, D., Langreder, N., Steinke, S., Rand, U., Simonelli, L., Heine, P. A., Ballmann, R., Schneider, K.-T., Roth, K. D. R., Ruschig, M., Riese, P., Eschke, K., Kim, Y., Schaeckermann, D., Pedotti, M., Kuhn, P., Zock-Emmenthal, S., Woehrle, J., Becker, M., Grashoff, M., Wenzel, E. V., Russo, G., Kroeger, A., Brunotte, L., Ludwig, S., Fuehner, V., Kraemer, S. D., Duebel, S., Varani, L., Roth, G., Cicin-Sain, L., Schubert, M., Hust, M.
10.1101/2020.06.05.135921 — Posted: 2020-06-05 Discussion: Onsite | Offsite
Comparative study of four SARS-CoV-2 Nucleic Acid Amplification Test (NAAT) platforms demonstrates that ID NOW performance is impaired substantially by patient and specimen type.
Lephart, P. R., Bachman, M. A., LeBar, W., McClellan, S. W., Barron, K., Schroeder, L., Newton, D. W.
10.1101/2020.06.04.135616 — Posted: 2020-06-05
Design of a Novel Multiplex Real Time RT-PCR Assay for SARS-CoV-2 Detection
Zhen, W., Berry, G. J.
10.1101/2020.06.04.135608 — Posted: 2020-06-05
An OpenData portal to share COVID-19 drug repurposing data in real time
Brimacombe, K. R., Zhao, T., Eastman, R. T., Hu, X., Wang, K., Backus, M., Baljinnyam, B., Chen, C. Z., Chen, L., Eicher, T., Ferrer, M., Fu, Y., Gorshkov, K., Guo, H., Hanson, Q. M., Itkin, Z., Kales, S. C., Klumpp-Thomas, C., Lee, E. M., Michael, S., Mierzwa, T., Patt, A., Pradhan, M., Renn, A., Shinn, P., Shrimp, J. H., Viraktamath, A., Wilson, K. M., Xu, M., Zakharov, A. V., Zhu, W., Zheng, W., Simeonov, A., Mathe, E. A., Lo, D. C., Hall, M. D., Shen, M.
10.1101/2020.06.04.135046 — Posted: 2020-06-05
Ultra-sensitive nanozyme-based chemiluminescence paper test for rapid diagnosis of SARS-CoV-2 infection
Liu, D., Ju, C., Han, C., Shi, R., Chen, X., Duan, D., Yan, J., Yan, X.
10.1101/2020.06.05.131748 — Posted: 2020-06-05
Several FDA-approved drugs effectively inhibit SARS-CoV-2 infection in vitro
Xiong, H.-L., Cao, J.-L., Shen, C.-G., Ma, J., Qiao, X., Shi, T., Yang, Y., Ge, S.-X., Zhang, J., Zhang, T.-Y., Yuan, Q., Xia, N.-S.
10.1101/2020.06.05.135996 — Posted: 2020-06-05
Characterization of the substitution hotspots in SARS-CoV-2 genome using BioAider and detection of a SR-rich region in N protein providing further evidence of its animal origin
Zhou, Z.-J., Qiu, Y., Ge, X.-Y.
10.1101/2020.06.04.135293 — Posted: 2020-06-05
Tocilizumab is associated with reduction of the risk of ICU admission and mortality in patients with SARS-CoV-2 infection
Moreno Garcia, E., Rico Caballero, V., Albiach, L., Aguero, D., Ambrosioni, J., Bodro, M., Cardozo, C., Chumbita, M., De la Mora, L., Garcia Pouton, N., Garcia Vidal, C., GonzalezCordon, A., Hernandez Meneses, M., Inciarte, A., Laguno, M., Leal, L., Linares, L., Macaya, I., Meira, F., Mensa, J., Moreno, A., Morata, L., Puerta Alcalde, P., Rojas, J., Sola, M., Torres, B., Torres, M., Tome, A., Castro, P., Fernandez, S., Nicolas, J. M., Almuedo Riera, A., Munoz, J., Fernandez, M. J., Marcos, M. A., Soy, D., Martinez, J. A., Garcia, F., Soriano, A.
10.1101/2020.06.05.20113738 — Posted: 2020-06-05

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* The Clinical Trials and Epidemiology subject categories are now closed to new submissions following the completion of bioRxiv's clinical research pilot project and launch of the dedicated health sciences server medRxiv (submit.medrxiv.org). New papers that report results of Clinical Trials must now be submitted to medRxiv. Most new Epidemiology papers also should be submitted to medRxiv, but if a paper contains no health-related information, authors may choose to submit it to another bioRxiv subject category (e.g., Genetics or Microbiology).