Channel:  Francis Crick Institute

1,234 Articles

Extensive and differential platinum chemotherapy mutagenesis in children
Wenger, A., Lee-Six, H., Dave, M., Layeghifard, M., Lawson, A. R. J., Abascal, F., Nicola, P. A., Treger, T. D., Ogbonnah, T., Parks, C., Oliver, T. R. W., Kennedy, J., Hodder, A., Anderson, N. D., Silva, F. L. T., Trinh, M. K., Dowe, T., Habarwaa, M., Sun, J. J., Assia-Zamora, S., Cortes-Cerisuelo, M., Jassem, W., Town, C., Dhawan, A., Jain, V., Straathof, K., Deheragoda, M., Martincorena, I., Palm, L., Hutchinson, J. C., Coorens, T. H. H., Trayers, C., Heaton, N., Shlien, A., Zen, Y., Rouhani, F. J., Behjati, S.
10.1101/2025.10.12.681852 — Posted: 2025-10-14
The SNCA A53T mutation sensitizes human neurons and microglia to ferroptosis
Mahoney-Sanchez, L., Clarke-Lucas, H., Penverne, A., Evans, J. R., D'Sa, K., Strohbuecker, S., Lopex Garcia, P., Cosker, K., Soltic, D., O'Callaghan, B. J., Griffiths, A., Pintchovski, S. A., Plun-Favreau, H., Hallqvist, J., Mills, K., Gandhi, S.
10.1101/2025.10.13.682089 — Posted: 2025-10-14
Ecological cues orchestrate concerted courtship in a Drosophila host specialist
Brand, P., Keller, K., Coleman, R. T., Eghbali, N. B., Zylka, S., Prieto-Godino, L. L., Ruta, V.
10.1101/2025.10.13.681913 — Posted: 2025-10-14
Cell cycle oscillations in a polarity network facilitate state switching by morphogenetic cues
Ng, K., Sebaa, H., Hirani, N., Chizh, A., Messi, Z., Bland, T., Sugioka, K., Goehring, N. W.
10.1101/2025.10.12.681824 — Posted: 2025-10-13
DNMT3A-R882 mutations intrinsically drive dysfunctional neutropoiesis from human haematopoietic stem cells
Mantica, G., Vedi, A., Tuval, A., Huerga Encabo, H., Hayler, D., Krzywon, A., Mitchell, E., Dunn, W. G., Biezuner, T., Bastos, H. P., Sham, K., Santoro, A., Lee, J., Williams, N., Danin, A., Chapal, N., Moskovitz, Y., Arruda, A., Fiorillo, E., Orru, V., Marongiu, M., McKinney, E., Cucca, F., Collin, M., Minden, M., Campbell, P., Vassiliou, G. S., Fabre, M. A., Nangalia, J., Bonnet, D., Shlush, L., Laurenti, E.
10.1101/2025.10.08.679225 — Posted: 2025-10-08
Inactivation of Airborne Pathogen Surrogates by Triethylene Glycol
Desai, G., Goldman, E., Jordan, W., Balarashti, J., Caravanos, J., Edgar, R. S., Grignard, E., Ramachandran, G., Mainelis, G.
10.1101/2025.08.08.669335 — Posted: 2025-10-08
Continuous evolution of a halogenase enzyme with improved solubility and activity for sustainable bioproduction
Pulschen, A. A., Booth, J., Satanowski, A., Soudy, C., Caro-Astorga, J., Ather, O., Patel, N., Alidoust, A., Aoudjane, S., Nematollahi, L., DeBenedictis, E.
10.1101/2025.10.08.681035 — Posted: 2025-10-08
Rapid expansion of podoplanin-positive fibroblasts following radiation limits the anti-tumour CD8+ T-cell response to radiotherapy.
Wilkins, A. C., Makris, S., Green, M., Hooper, S., Mikolajczak, A., Giangreco, G., Allanki, S., Nye, E., Connick, E., Mitter, R., Cooper, S., Durie, E., Pedersen, M., Burley, A., O'Fee, K., O'Leary, B., Shewring, D., Ramsden, Z., Melcher, A., Harrington, K., Somaiah, N., Acton, S. E., Sahai, E.
10.1101/2025.10.07.680949 — Posted: 2025-10-07
Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates
Davi, V., Parutto, P., Crapart, C., Zhang, Y., Konno, T., Chambers, J., Franklin, J. P., Maddison, D., Awadelkareem, M. A., Devine, M. J., Koslover, E., Avezov, E.
10.1101/2025.10.06.677012 — Posted: 2025-10-07
Apicortin defines the Plasmodium apical conoid body during transmission but is dispensable for the parasite life cycle
Zeeshan, M., Mishra, A., Pashley, S. L., Markus, R., Brady, D., Holder, A. A., Moores, C., Tewari, R.
10.1101/2025.10.01.678762 — Posted: 2025-10-03

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