Channel:  Babraham Institute

183 Articles

Paradoxical Activation of GCN2 by ATP-competitive inhibitors via allosteric activation and autophosphorylation
Neill, G., Vinciauskaite, V., Paul, M., Gilley, R., Cook, S. J., Masson, G. R.
10.1101/2024.08.14.606984 — Posted: 2024-08-15
Phospholipase Cgamma regulates lacrimal gland branching by competing with PI3K in phosphoinositide metabolism
Wang, Q., Tao, C., Wu, Y., Anderson, K. E., Hannan, A., Lin, C.-s., Hawkins, P. T., Stephens, L., Zhang, X.
10.1101/2024.06.28.601066 — Posted: 2024-07-02
The LCLAT1/LYCAT acyltransferase is required for EGF-mediated phosphatidylinositol-3,4,5-trisphosphate generation and Akt signalling
Chan, V., Camardi, C., Zhang, K., Orofiamma, L., Anderson, K. E., Hoque, J., Bone, L., Awadeh, Y., Lee, D. K. C., Fu, N. J., Chow, J. T. S., Salmena, L., Stephens, L. R., Hawkins, P. T., Antonescu, C. N., Botelho, R. J.
10.1101/2023.01.26.524308 — Posted: 2024-06-26
A targetable PREX2/RAC1/PI3Kβ signalling axis confers resistance to clinically relevant therapeutic approaches in melanoma
Ford, C. A., Koludrovic, D., Centeno, P. P., Foth, M., Tsonou, E., Vlahov, N., Sphyris, N., Gilroy, K., Bull, C., Nixon, C., Serrels, B., Munro, A. F., Dawson, J. C., Carragher, N. O., Pavet, V., Hornigold, D. C., Dunne, P. D., Downward, J., Welch, H. C. E., Barry, S. T., Sansom, O. J., Campbell, A. D.
10.1101/2024.02.26.580534 — Posted: 2024-02-28
Tissue-resident regulatory T cells exert dualistic anti-tumour and pro-repair function in the exocrine pancreas
Stockis, J., Yip, T., Raghunathan, S., Garcia, C., Lee, S., Simpson, C., Silvain, S., Schuijs, M. J., Araos, J., Png, S., Raddi, G., Bricard, O., So, T. Y., Mack, S., Papadopoulos, P., Sawle, A., Jodrell, D. I., McKenzie, A. N. J., Thaventhiran, J., Clatworthy, M., Biffi, G., Saeb-Parsy, K., Liston, A., Halim, T. Y. F.
10.1101/2024.02.15.580302 — Posted: 2024-02-19
Regulation of IFNgamma production by ZFP36L2 in T cells is context-dependent
Zandhuis, N. D., Guislain, A., Popalzij, A., Engels, S., Popovic, B., Turner, M., Wolkers, M. C.
10.1101/2024.02.09.579641 — Posted: 2024-02-12
Small molecule modulation of a redox-sensitive stress granule protein dissolves stress granules with beneficial outcomes for familial amyotrophic lateral sclerosis models
Uechi, H., Sridharan, S., Nijssen, J., Bilstein, J., Iglesias-Artola, J. M., Kishigami, S., Casablancas-Antras, V., Poser, I., Martinez, E. J., Boczek, E., Wagner, M., Tomschke, N., de Jesus Domingues, A. M., Pal, A., Doeleman, T., Kour, S., Anderson, E. N., Stein, F., Lee, H. O., Zhang, X., Fritsch, A. W., Jahnel, M., Fursch, J., Murthy, A. C., Alberti, S., Bickle, M., Fawzi, N. L., Nadler, A., David, D. C., Pandey, U. B., Hermann, A., Stengel, F., Davis, B. G., Baldwin, A. J., Savitski, M. M., Hyman, A. A., Wheeler, R. J.
10.1101/721001 — Posted: 2024-01-05
Single-cell analysis reveals lasting immunological consequences of influenza infection and respiratory immunisation in the pig lung
Muir, A., Paudyal, B., Schmidt, S., Sedaghat-Rostani, E., Chakravarti, S., Villanueva Hernandez, S., Moffat, K., Polo, N., Angelopoulos, N., Schmidt, A., Tenbusch, M., Freimanis, G., Gerner, W., Richard, A. C., Tchilian, E.
10.1101/2023.12.19.572318 — Posted: 2023-12-19
A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV (PADI4) regulation
Bertran, M. T., Walmsley, R., Cummings, T. F. M., Aramburu, I., Benton, D. J., Assalaarachchi, J., Chasampalioti, M., Swanton, T., Joshi, D., Federico, S., Okkenhaug, H., Yu, L., Oxley, D., Walker, S., Papayannopoulos, V., Suga, H., Christophorou, M. A., Walport, L. J.
10.1101/2023.12.12.571217 — Posted: 2023-12-12
Protein tyrosine phosphatase receptor kappa regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity
Gilglioni, E. H., Li, A., Saint-Pierre Wijckmans, W., Shen, T.-K., Perez-Chavez, I., Hovhannisyan, G., Lisjak, M., Negueruela, J., Vandenbempt, V., Bauza-Martinez, J., Herranz, J. M., Ezerina, D., Demine, S., Feng, Z., Vignane, T., Otero-Sanchez, L., Lambertucci, F., Prasnicka, A., Deviere, J., Hay, D. C., Encinar, J. A. N., Singh, S. P., Messens, J., Filipovic, M. R., Sharpe, H. J., Trepo, E., Wu, W., Gurzov, E. N.
10.1101/2023.12.01.569004 — Posted: 2023-12-01

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