Channel:  Aligning Science Across Parkinson's (ASAP)

480 Articles

The SNCA A53T mutation sensitizes human neurons and microglia to ferroptosis
Mahoney-Sanchez, L., Clarke-Lucas, H., Penverne, A., Evans, J. R., D'Sa, K., Strohbuecker, S., Lopex Garcia, P., Cosker, K., Soltic, D., O'Callaghan, B. J., Griffiths, A., Pintchovski, S. A., Plun-Favreau, H., Hallqvist, J., Mills, K., Gandhi, S.
10.1101/2025.10.13.682089 — Posted: 2025-10-14
Proteome Landscapes Decode Organelle Vulnerabilities in cortical and dopaminergic-like induced neurons Across Lysosomal Storage Disorders
Kraus, F., He, Y., Jiang, Y., Li, D., Ambaw, Y. A., Gasparoli, F. M., Paulo, J. A., Walther, T. C., Farese, R., Gygi, S. P., Wilfling, F., Harper, J. W.
10.1101/2025.10.08.681047 — Posted: 2025-10-08
Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress
Ehses, K. L., Lopez-Alonso, J. P., Antico, O., Azem, A., Muqit, M., Ubarretxena-Belandia, I., Fernandez-Busnadiego, R.
10.1101/2025.10.06.680693 — Posted: 2025-10-06
Programmable self-assembling system to model intracellular protein aggregation and decode neurodegenerative diseases
Fan, Y., Hoang, J., Steele, C., Benchetrit, Y., Dutta, S., Coughlin, G., Appling, N., Ding, X., Lin, C., Qu, Z., Mackey, E. D., Gradinaru, V.
10.1101/2025.03.06.641009 — Posted: 2025-10-06
Polygenic risk scores and Parkinson's disease in South Africa: Moving towards ancestry-informed disease prediction
Step, K., Ndong Sima, C. A. A., Grant, S., Kim, J. J., Waldo, E., Bardien, S., Mata, I., Global Parkinson's Genetics Program
10.1101/2025.09.29.25336747 — Posted: 2025-09-30
Fall frequency, Risk Factors, and Outcomes in Parkinson's disease: A Cross-Sectional Analysis
Vizcarra, J. A., Hefter, K., Lafontant, D.-E., Duong, M. T., Ertefaie, A., Litt, B., Bassett, D. S., Siderowf, A., The Parkinson's Progression Markers Initiative
10.1101/2025.08.05.25332959 — Posted: 2025-09-25
Faecalibacterium prausnitzii, depleted in the Parkinson's disease microbiome, improves motor deficits in α-synuclein overexpressing mice
Moiseyenko, A., Antonello, G., Schonhoff, A. M., Boktor, J. C., Long, K., Dirks, B., Oguienko, A. D., Winnett, A. V., Simpson, P., Daeizadeh, D., Ismagilov, R. F., Krajmalnik-Brown, R., Segata, N., Waldron, L. D., Mazmanian, S. K.
10.1101/2025.09.18.677192 — Posted: 2025-09-21
A molecular atlas of cell-type specific signatures in the parkinsonian striatum.
Graziano, M., Mantas, I., Masarapu, Y., Frapard, S., Garza, R., Adami, A., Fazal, S., Quaegebeur, A., Barker, R., Jakobsson, J., Giacomello, S., Meletis, K.
10.1101/2025.09.09.675138 — Posted: 2025-09-10
TDP-43 loss of function drives aberrant splicing in Parkinson's disease
Brenton, J. W., Follett, J., Nirujogi, R., Toomey, C. E., Lopez-Garcia, P., Evans, J. R., Lee, Y. J., Syed, K. M., Rocamora Perez, G., Fairbrother-Browne, A., D'Sa, K., Grant-Peters, M., Lachica, J., Hicks, A. R., Wagen, A. Z., O'Callaghan, B., Macpherson, H., Montgomery, K.-a., Busquets, O., Reynolds, R. H., Garcia Ruiz, S., Cao, T., Chen, Z., Plun-Favreau, H., Wong, P. C., Farrer, M., Lashley, T., Soldner, F., Hockemeyer, D., Alessi, D., Wood, N. W., Hardy, J., Rio, D. C., Jaunmuktane, Z., Gustavsson, E. K., Gandhi, S., Ryten, M.
10.1101/2025.09.04.673943 — Posted: 2025-09-09
Proteome-wide impact of LRRK1 and 2 inhibitors on protein interactions and phosphorylation
Jansen, J., Wendel, M., Raig, N. D., Kraus, T. V., Surridge, K. J., Mahesula, S., Richter-Muller, N., Mathea, S., Reck-Peterson, S. L., Knapp, S., Stengel, F.
10.1101/2025.09.03.674114 — Posted: 2025-09-07

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