COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

31,516 Articles (22,870 medRxiv, 8,646 bioRxiv)

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Orally Bioavailable SARS-CoV-2 Protease Inhibitors Bearing a Hydroxymethyl Ketone Warhead
Elshan, N. G. R. D., Wolff, K. C., Weiss, F., Ghorai, S., Grabovyi, G., Wilson, K., Riva, L., Woods, A. K., Pedroarena, J., Nazarian, A., Liu, Y., Mazumdar, W., Song, L., Okwor, N., Malvin, J., Bakowski, M. A., Kirkpatrick, M. G., Gebara-Lamb, A., Huang, E., Nguyen-Tran, V. T. B., Chi, V., Li, S., Lee, K.-J., McNamara, C. W., Gupta, A. K., Rahimi, A., Chen, J. J., Joseph, S. B., Schultz, P. G., Chatterjee, A. K.
10.64898/2026.05.15.725542 — Posted: 2026-05-18
Environmental stochasticity can account for patterns of within-host respiratory virus evolution
Xiao, W. F., Farjo, M. N., Lowen, A. C., Koelle, K.
10.64898/2026.05.15.725410 — Posted: 2026-05-18
Expansion Revealing of Pathology Resolves Nanostructures Associated with Inflammatory Phenotypes in COVID-19 Decedent Human Brain Tissue
Stanton, A. E., Kang, J., Blanchard, J. W., Boix, C. A., Schroeder, M. E., Lee, Y., Su, H., Wang, S., Yu, E., Emenari, A., Peng, Z., Agbas, E., Cerit, O., Park, D., Zhang, R., Bennett, D. A., Yin, P., Kellis, M., Langer, R., Boyden, E., Tsai, L.-H.
10.64898/2026.05.14.725177 — Posted: 2026-05-15
A Structural Domain in the genomic RNA of SARS-CoV-2 Folds into a Compact Granular Structure without the N protein: A Single-Molecule Fluorescence Spectroscopic Investigation
Kimura, T., Katayama, T., Ishikawa, S., Mitra, S., Yamano, Y., Onizuka, K., Nagatsugi, F., Laha, S., Naganathan, A. N., Itoh, Y., Takahashi, S.
10.64898/2026.05.15.725307 — Posted: 2026-05-15
Immunological imprinting shapes the cross-reactive antibody responses to the KP.2 and LP.8.1 vaccine doses
Kumar, S., Lai, L., Ellis, M., Patel, A. B., Joshi, D. J., Velden, J. V., Faraj, J. Z. A., Wimalasena, S. T., Pallavi, R. R., Iriss, J., Bechnak, K., Edupuganti, S., Rouphael, N., Ortlund, E., Moreno, A., Menachery, V. D., Zarnitsyna, V. I., Wrammert, J., Suthar, M. S.
10.64898/2026.05.13.725047 — Posted: 2026-05-15
Pathogen-specific host responses define distinct pneumonia endotypes in the human lung
Markov, N. S., Mozejko, M., Guggilla, V., Łazecka, M., Donnelly, H. K., Donayre, A., Fenske, S., Peltekian, A., Puczko-Szymanski, B., Szymczak, P., Izdebski, A., Luo, L., Senkow, K. J., Cusick, L., Yu, Z., Swaminathan, S., Lu, Z., Abdala-Valencia, H., Phan, D., Clepp, R. K., Rasmussen, L. V., Pawlowski, A., Pickens, C. O., Nadig, N. R., Walunas, T., Tighe, R., The Neu-Lung Investigators, , Wunderink, R. G., Budinger, G. S., Morales-Nebreda, L., Gao, C. A., Singer, B. D., Misharin, A. V., Szczurek, E., The NU SCRIPT Study Investigators
10.64898/2026.05.12.724509 — Posted: 2026-05-14
AI-discovered protein fragments as generalizable regulators of biomolecular condensates
Savinov, A., Sadasivan, J., White, K. J., Rubien, J. D., Li, G.-W., Case, L. B.
10.64898/2026.05.08.723928 — Posted: 2026-05-12
Crude Fucus vesiculosus fucoidan demonstrates superior SARS-CoV-2 antiviral activity compared to its pure form: binding kinetics and functional studies
Dudek, A., Janapatla, R. P., Chen, C. L., Chiu, C. H.
10.64898/2026.05.07.723385 — Posted: 2026-05-12
Temperature-Dependent Replication and Sensitivity to Innate Immunity of Human Coronavirus HKU1
Buchrieser, J., Thuillier, E., Postal, J., Wileveau, A., Guivel-Benhassine, F., Staropoli, I., Saunders, N., Planas, D., Sugrue, J., Bondet, V., Fernandez, I., Bontems, F., Porrot, F., Petiot, C., Prot, M., Jungbauer-Groznica, M., Arowas, L., Michel, V., Blanc, C., Trouillet-Assant, S., Bruel, T., Rey, F. A., Rameix-Welti, M.-A., Casartelli, N., Fontanet, A., White, M., Duffy, D., Simon-Loriere, E., Schwartz, O.
10.64898/2026.05.07.723210 — Posted: 2026-05-12
SARS CoV 2 Associated Shifts in the Upper Respiratory Tract Mycobiome in Non Hospitalized Cases
Tomar, S. S., Khairnar, K.
10.64898/2026.05.07.26352639 — Posted: 2026-05-10

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* The Clinical Trials and Epidemiology subject categories are now closed to new submissions following the completion of bioRxiv's clinical research pilot project and launch of the dedicated health sciences server medRxiv (submit.medrxiv.org). New papers that report results of Clinical Trials must now be submitted to medRxiv. Most new Epidemiology papers also should be submitted to medRxiv, but if a paper contains no health-related information, authors may choose to submit it to another bioRxiv subject category (e.g., Genetics or Microbiology).