bioRxiv Channel: Drug Development and Clinical Therapeutics https://biorxiv.org This feed contains articles for bioRxiv Channel "Drug Development and Clinical Therapeutics " bioRxiv bioRxiv https://biorxiv.org <![CDATA[ Practical Unidentifiability Of Receptor Density In Target Mediated Drug Disposition Models Can Lead To Over-Interpretation Of Drug Concentration Data ]]> https://biorxiv.org/cgi/content/short/123240v1?rss=1" Stein, A. 2017-04-02 doi:10.1101/123240 Cold Spring Harbor Laboratory Press 2017-04-02 <![CDATA[ Costing ‘the’ MTD ]]> https://biorxiv.org/cgi/content/short/150821v1?rss=1" Norris, D. C. 2017-06-16 doi:10.1101/150821 Cold Spring Harbor Laboratory Press 2017-06-16 <![CDATA[ Precautionary Coherence Unravels Dose Escalation Designs ]]> https://biorxiv.org/cgi/content/short/240846v1?rss=1" Norris, D. C. 2017-12-29 doi:10.1101/240846 Cold Spring Harbor Laboratory Press 2017-12-29 <![CDATA[ Improving the Generation and Selection of Virtual Populations in Quantitative Systems Pharmacology Models ]]> https://biorxiv.org/cgi/content/short/196089v1?rss=1" Rieger, T. R. Allen, R. J. Bystricky, L. Chen, Y. Colopy, G. Cui, Y. Gonzalez, A. Liu, Y. White, R. Everett, R. Banks, H. T. Musante, C. J. 2017-09-29 doi:10.1101/196089 Cold Spring Harbor Laboratory Press 2017-09-29 <![CDATA[ Costing ‘the’ MTD … in 2-D ]]> https://biorxiv.org/cgi/content/short/370817v1?rss=1" Norris, D. C. 2018-07-17 doi:10.1101/370817 Cold Spring Harbor Laboratory Press 2018-07-17 <![CDATA[ Complex versus simple models: ion-channel cardiac toxicity prediction ]]> https://biorxiv.org/cgi/content/short/206946v1?rss=1" Mistry, H. 2017-10-20 doi:10.1101/206946 Cold Spring Harbor Laboratory Press 2017-10-20 <![CDATA[ Population-based mechanistic modeling allows for quantitative predictions of drug responses across cell types ]]> https://biorxiv.org/cgi/content/short/176321v1?rss=1" Gong, J. Q. X. Sobie, E. A. 2017-08-14 doi:10.1101/176321 Cold Spring Harbor Laboratory Press 2017-08-14 <![CDATA[ Urinary biomarker and histopathological evaluation of vancomycin and piperacillin-tazobactam nephrotoxicity in comparison with vancomycin in a rat model and a confirmatory cellular model ]]> https://biorxiv.org/cgi/content/short/568907v1?rss=1" 0.2).nnConclusionsVAN+TZP does not cause more kidney injury than VAN alone in a rat model of VIKI or in rat kidney epithelial cells. ]]> Pais, G. M. Liu, J. Avedissian, S. N. Xanthos, T. Chalkias, A. d'Aloja, E. Locci, E. Gilchrist, A. Prozialeck, W. C. Rhodes, N. Lodise, T. P. Fitzgerald, J. C. Downes, K. Zuppa, A. Scheetz, M. H. 2019-03-06 doi:10.1101/568907 Cold Spring Harbor Laboratory Press 2019-03-06 <![CDATA[ Guiding dose selection of monoclonal antibodies using a new parameter (AFTIR) for characterizing ligand binding systems ]]> https://biorxiv.org/cgi/content/short/432500v1?rss=1" nView larger version (30K):norg.highwire.dtl.DTLVardef@6895d7org.highwire.dtl.DTLVardef@4566e0org.highwire.dtl.DTLVardef@6515e8org.highwire.dtl.DTLVardef@8168ea_HPS_FORMAT_FIGEXP M_FIG O_FLOATNOFig. 1C_FLOATNO Graphical AbstractnnC_FIG ]]> Ahmed, S. Ellis, M. Li, H. Pallucchini, L. Stein, A. M. 2018-10-03 doi:10.1101/432500 Cold Spring Harbor Laboratory Press 2018-10-03 <![CDATA[ Accelerated Predictive Healthcare Analytics with Pumas, A High Performance Pharmaceutical Modeling and Simulation Platform ]]> https://biorxiv.org/cgi/content/short/2020.11.28.402297v1?rss=1" Rackauckas, C. V. Ma, Y. Noack, A. Dixit, V. Mogensen, P. Byrne, S. Maddhashiya, S. Calderon, J. B. S. Nyberg, J. Gobburu, J. Ivaturi, V. 2020-11-30 doi:10.1101/2020.11.28.402297 Cold Spring Harbor Laboratory Press 2020-11-30 <![CDATA[ Erythropoietin and miRNA profiles during the menstrual cycle in relation to hematological and lipid biomarkers ]]> https://biorxiv.org/cgi/content/short/2021.11.05.467468v1?rss=1" Bergstrom, H. H. Heiland, C. Bjorkhem-Bergman, L. Ekstrom, L. 2021-11-05 doi:10.1101/2021.11.05.467468 Cold Spring Harbor Laboratory Press 2021-11-05