bioRxiv Channel: NF Open Science Initiative https://biorxiv.org This feed contains articles for bioRxiv Channel "NF Open Science Initiative" bioRxiv bioRxiv https://biorxiv.org <![CDATA[ Distinctive epigenomic alterations in NF1-deficient cutaneous and plexiform neurofibromas drive differential MKK/P38 signaling ]]> https://biorxiv.org/cgi/content/short/833467v1?rss=1" Grit, J. L. Johnson, B. K. Essenburg, C. J. Dischinger, P. S. Campbell, S. Triche, T. J. Graveel, C. R. Steensma, M. R. 2019-12-02 doi:10.1101/833467 Cold Spring Harbor Laboratory Press 2019-12-02 <![CDATA[ Therapeutic vulnerability to ATR inhibition in concurrent NF1 and ATRX-deficient high-grade solid tumors ]]> https://biorxiv.org/cgi/content/short/2022.02.03.479021v1?rss=1" Yuan, M. Eberhart, C. G. Pratilas, C. A. Blakeley, J. O. Davis, C. Stojanova, M. Reilly, K. Meeker, A. K. Heaphy, C. M. Rodriguez, F. J. 2022-02-03 doi:10.1101/2022.02.03.479021 Cold Spring Harbor Laboratory Press 2022-02-03 <![CDATA[ Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology ]]> https://biorxiv.org/cgi/content/short/2022.04.29.490078v1?rss=1" Bhatia^, H. Larsson^, A. T. Calizo^, A. Pollard, K. Zhang, X. Conniff, E. Tibbitts, J. F. Osum, S. H. Williams, K. B. Crampton, A. L. Jubenville, T. Schefer, D. Yang, K. Lyu, Y. Bade, J. Pino, J. C. Gosline, S. J. Pratilas, C. A. Largaespada, D. A. Wood, D. K. Hirbe, A. C. 2022-05-02 doi:10.1101/2022.04.29.490078 Cold Spring Harbor Laboratory Press 2022-05-02 <![CDATA[ Integrative analysis identifies candidate tumor microenvironment and intracellular signaling pathways that define tumor heterogeneity in NF1 ]]> https://biorxiv.org/cgi/content/short/2020.01.13.904771v1?rss=1" Banerjee, J. Allaway, R. J. Taroni, J. N. Baker, A. Zhang, X. Moon, C. I. Blakeley, J. O. Guinney, J. Hirbe, A. Greene, C. S. Gosline, S. J. 2020-01-14 doi:10.1101/2020.01.13.904771 Cold Spring Harbor Laboratory Press 2020-01-14 <![CDATA[ A clinically and genomically annotated nerve sheath tumor biospecimen repository. ]]> https://biorxiv.org/cgi/content/short/2019.12.19.871897v1?rss=1" Pollard, K. Banerjee, J. Doan, X. Wang, J. Guo, X. Allaway, R. J. Langmead, S. Slobogean, B. Meyer, C. Loeb, D. Morris, C. Belzberg, A. Blakeley, J. O. Rodriguez, F. Guinney, J. Gosline, S. J. Pratilas, C. A. 2019-12-19 doi:10.1101/2019.12.19.871897 Cold Spring Harbor Laboratory Press 2019-12-19 <![CDATA[ Genomic patterns of malignant peripheral nerve sheath tumour (MPNST) evolution correlate with clinical outcome and are detectable in cell-free DNA ]]> https://biorxiv.org/cgi/content/short/2022.05.03.490481v1?rss=1" Cortes-Ciriano, I. Steele, C. D. Piculell, K. G. Al-Ibraheemi, A. Eulo, V. Bui, M. M. Chatzipli, A. Dickson, B. C. Borcherding, D. C. Feber, A. Galor, A. Hart, J. Jones, K. B. Jordan, J. T. Kim, R. H. Lindsay, D. Miller, C. Nishida, Y. Proszek, P. Serrano, J. Sundby, R. T. Szymanski, J. J. Ullrich, N. J. Viskochil, D. Wang, X. Snuderl, M. Park, P. J. Flanagan, A. M. Hirbe, A. C. Pillay, N. Miller, D. T. 2022-05-05 doi:10.1101/2022.05.03.490481 Cold Spring Harbor Laboratory Press 2022-05-05 <![CDATA[ A genetic mouse model with postnatal Nf1 and p53 loss recapitulates the histology and transcriptome of human malignant peripheral nerve sheath tumor ]]> https://biorxiv.org/cgi/content/short/2021.05.03.442481v1?rss=1" Inoue, A. Janke, L. J. Gudenas, B. L. Jin, H. Fan, Y. Pare, J. Clay, M. R. Northcott, P. A. Hirbe, A. C. Cao, X. 2021-05-04 doi:10.1101/2021.05.03.442481 Cold Spring Harbor Laboratory Press 2021-05-04 <![CDATA[ A detailed landscape of genomic alterations in malignant peripheral nerve sheath tumor cell lines challenges the current MPNST diagnosis ]]> https://biorxiv.org/cgi/content/short/2022.05.07.491026v1?rss=1" Magallon-Lorenz, M. Terribas, E. Fernandez, M. A. Requena, G. Rosas, I. Mazuelas, H. Uriarte, I. Negro, A. Castellanos, E. Blanco, I. DeVries, G. Kawashima, H. Legius, E. Brems, H. Mautner, V. Kluwe, L. Ratner, N. Wallace, M. R. Fernandez-Rodriguez, J. Lazaro, C. Fletcher, J. Reuss, D. Carrio, M. Gel, B. Serra, E. 2022-05-08 doi:10.1101/2022.05.07.491026 Cold Spring Harbor Laboratory Press 2022-05-08 <![CDATA[ Oncogenic RAS-MET signal interactions are modulated by P53 status in NF1-related MPNSTs ]]> https://biorxiv.org/cgi/content/short/199026v1?rss=1" Pridgeon, M. G. Tovar, E. A. Essenburg, C. J. Madaj, Z. Boguslawski, E. A. Dischinger, P. S. Peacock, J. D. Maina, F. Dono, R. Winn, M. E. Graveel, C. R. Steensma, M. R. 2017-10-05 doi:10.1101/199026 Cold Spring Harbor Laboratory Press 2017-10-05 <![CDATA[ Genomic MET amplification occurs early in NF1-related malignant peripheral nerve sheath tumor (MPNST) progression and is a potent therapeutic target ]]> https://biorxiv.org/cgi/content/short/199000v1?rss=1" Peacock, J. D. Pridgeon, M. G. Tovar, E. A. Essenburg, C. J. Bowman, M. J. Madaj, Z. Koeman, J. Grit, J. Dodd, R. D. Cardona, D. M. Chen, M. Kirsch, D. Maina, F. Dono, R. Winn, M. E. Graveel, C. R. Steensma, M. R. 2017-10-05 doi:10.1101/199000 Cold Spring Harbor Laboratory Press 2017-10-05 <![CDATA[ Sex-dependent differences in pain and sleep in a porcine model of Neurofibromatosis type 1 ]]> https://biorxiv.org/cgi/content/short/495358v1?rss=1" Khanna, R. Moutal, A. White, K. Chefdeville, A. Negrao de Assis, P. Cai, S. Swier, V. J. Bellampalli, S. S. Giunta, M. D. Darbro, B. W. Quelle, D. E. Sieren, J. C. Wallace, M. R. Rogers, C. S. Meyerholz, D. K. Weimer, J. M. 2018-12-20 doi:10.1101/495358 Cold Spring Harbor Laboratory Press 2018-12-20 <![CDATA[ Purinergic receptor P2RY14 cAMP signaling regulates EGFR-driven Schwann cell precursor self-renewal and nerve tumor initiation in neurofibromatosis. ]]> https://biorxiv.org/cgi/content/short/2021.09.24.461701v1?rss=1" Patritti-Cram, J. Wu, J. Kuninaka, S. Coover, R. A. Hennigan, R. F. Rizvi, T. A. Chaney, K. E. Ravindran, R. Cancelas, J. A. Spinner, R. J. Ratner, N. 2021-09-24 doi:10.1101/2021.09.24.461701 Cold Spring Harbor Laboratory Press 2021-09-24 <![CDATA[ Synthetic lethal screening identifies existing drugs with selective viability effects on Neurofibromatosis type-1 model systems ]]> https://biorxiv.org/cgi/content/short/2021.12.20.473481v1?rss=1" Wang, Y. Stevens, M. Mandigo, T. R. Bouley, S. J. Sharma, A. Sengupta, S. Housden, A. E. Perrimon, N. Walker, J. A. Housden, B. E. 2021-12-20 doi:10.1101/2021.12.20.473481 Cold Spring Harbor Laboratory Press 2021-12-20 <![CDATA[ Loss of NF1 causes tactile hypersensitivity and impaired synaptic transmission in a Drosophila model of autism spectrum disorder ]]> https://biorxiv.org/cgi/content/short/2022.03.04.482984v1?rss=1" Dyson, A. Garg, S. Evans, G. Baines, R. 2022-03-04 doi:10.1101/2022.03.04.482984 Cold Spring Harbor Laboratory Press 2022-03-04 <![CDATA[ Cellular mechanisms of heterogeneity in NF2-mutant schwannoma ]]> https://biorxiv.org/cgi/content/short/2020.12.31.424999v1?rss=1" MacKenzie, C. C. Liu, C. H. Vitte, J. Giovannini, M. McClatchey, A. I. 2021-01-03 doi:10.1101/2020.12.31.424999 Cold Spring Harbor Laboratory Press 2021-01-03 <![CDATA[ Schwann cells modulate nociception in neurofibromatosis 1 ]]> https://biorxiv.org/cgi/content/short/2023.03.18.533004v1?rss=1" View larger version (23K): org.highwire.dtl.DTLVardef@d17177org.highwire.dtl.DTLVardef@706f56org.highwire.dtl.DTLVardef@19db1ccorg.highwire.dtl.DTLVardef@3e28d_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Raut, N. G. Maile, L. A. Oswalt, L. M. Mitxelena, I. Adlakha, A. Sprague, K. L. Rupert, A. R. Bokros, L. Hofmann, M. C. Patritti-Cram, J. Rizvi, T. A. Queme, L. F. Choi, K. Ratner, N. Jankowski, M. P. 2023-03-19 doi:10.1101/2023.03.18.533004 Cold Spring Harbor Laboratory Press 2023-03-19 <![CDATA[ Reciprocal inflammatory signaling in an ex-vivo explant model for neurofibromatosis type 1-related cutaneous neurofibromas ]]> https://biorxiv.org/cgi/content/short/2022.10.06.510849v1?rss=1" Grit, J. Turner, L. Essenburg, C. Dischinger, P. Shurlow, N. Pate, M. Graveel, C. R. Steensma, M. R. 2022-10-06 doi:10.1101/2022.10.06.510849 Cold Spring Harbor Laboratory Press 2022-10-06 <![CDATA[ Antisense oligonucleotides targeting exon 11 are able to partially rescue the Neurofibromatosis Type 2 phenotype in vitro ]]> https://biorxiv.org/cgi/content/short/2022.02.11.479859v1?rss=1" Catasus, N. Rosas, I. Bonache, S. Negro, A. Plana, A. Salvador, H. Serra, E. Blanco, I. CASTELLANOS, E. 2022-02-11 doi:10.1101/2022.02.11.479859 Cold Spring Harbor Laboratory Press 2022-02-11 <![CDATA[ CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon restoration of RB function in malignant peripheral nerve sheath tumors ]]> https://biorxiv.org/cgi/content/short/2023.02.02.526674v1?rss=1" Wang, J. Calizo, A. Zhang, L. Pino, J. C. Lyu, Y. Pollard, K. Zhang, X. Larsson, A. T. Conniff, E. Llosa, N. Wood, D. K. Largaespada, D. A. Moody, S. E. Gosline, S. J. Hirbe, A. C. Pratilas, C. A. 2023-02-03 doi:10.1101/2023.02.02.526674 Cold Spring Harbor Laboratory Press 2023-02-03