bioRxiv Channel: Albert Einstein College of Medicine
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https://biorxiv.org
https://biorxiv.org/cgi/content/short/004853v1?rss=1"
Esther R. BerkoMasako SuzukiFaygel BerenChristophe LemetreChristine M. AlaimoR. Brent CalderKaren Ballaban-GilBatya GounderKaylee KampfJill KirschenShahina B. MaqboolZeineen MominDavid M. ReynoldsNatalie RussoLisa ShulmanEdyta StasiekJessica TozourMaria Valicenti-McDermottShenglong WangBrett S. AbrahamsJoseph HargitaiDov InbarZhengdong ZhangJoseph D. BuxbaumSophie MolholmJohn J. FoxeRobert W. MarionAdam AutonJohn Greally2014-05-06doi:10.1101/004853Cold Spring Harbor Laboratory Press2014-05-06
https://biorxiv.org/cgi/content/short/007591v1?rss=1"
N. Ari WijetungaFabien DelahayeYong Mei ZhaoAaron GoldenJessica C MarFrancine H. EinsteinJohn M. Greally2014-08-01doi:10.1101/007591Cold Spring Harbor Laboratory Press2014-08-01
https://biorxiv.org/cgi/content/short/008482v1?rss=1"
Fabien DelahayeNeil Ari WijetungaHye J HeoJessica N TozourYong Mei ZhaoJohn M GreallyFrancine H Einstein2014-08-27doi:10.1101/008482Cold Spring Harbor Laboratory Press2014-08-27
https://biorxiv.org/cgi/content/short/020545v1?rss=1"
Julie NadelRodoniki AthanasiadouChristophe LemetreNeil Ari WijetungaPilib Ó BroinHanae SatoZhengdong ZhangJeffrey JeddelohCristina MontagnaAaron GoldenCathal SeoigheJohn M. Greally2015-06-07doi:10.1101/020545Cold Spring Harbor Laboratory Press2015-06-07
https://biorxiv.org/cgi/content/short/025809v1?rss=1"
Yedael Y. WaldmanArjun BiddandaNatalie R. DavidsonPaul Billing-RossMaya DubrovskyChristopher L. CampbellCarole OddouxEitan FriedmanGil AtzmonEran HalperinHarry OstrerAlon Keinan2015-08-31doi:10.1101/025809Cold Spring Harbor Laboratory Press2015-08-31
https://biorxiv.org/cgi/content/short/031070v1?rss=1"
Joao XavierWilliam Chang2015-11-09doi:10.1101/031070Cold Spring Harbor Laboratory Press2015-11-09
https://biorxiv.org/cgi/content/short/040162v1?rss=1"
Jason Meyer SheltzerJulie H. KoNicole C. Habibe BurgosErica S. ChungColleen M. MeehlVerena PasseriniZuzana StorchovaAngelika Amon2016-02-19doi:10.1101/040162Cold Spring Harbor Laboratory Press2016-02-19
https://biorxiv.org/cgi/content/short/040337v1?rss=1"
Yushu ChenShashank BharillZeynep AltunRobert O'HaganBrian CoblitzEhud I. IsacoffMartin Chalfie2016-02-19doi:10.1101/040337Cold Spring Harbor Laboratory Press2016-02-19
https://biorxiv.org/cgi/content/short/059436v1?rss=1"
Vagheesh M NarasimhanRaheleh RahbariAylwyn ScallyArthur WusterDan MasonYali XueJohn WrightRichard C TrembathEamonn R MaherDavid A van HeelAdam AutonMatthew E HurlesChris Tyler-SmithRichard Durbin2016-06-17doi:10.1101/059436Cold Spring Harbor Laboratory Press2016-06-17
https://biorxiv.org/cgi/content/short/066043v1?rss=1"
Dean BoboMikhail LipatovJuan L. Rodriguez-FloresAdam AutonBrenna M Henn2016-07-26doi:10.1101/066043Cold Spring Harbor Laboratory Press2016-07-26
https://biorxiv.org/cgi/content/short/068403v1?rss=1"
Raghurama P HegdeSteven C AlmoUdupi A Ramagopal2016-08-08doi:10.1101/068403Cold Spring Harbor Laboratory Press2016-08-08
https://biorxiv.org/cgi/content/short/069179v1?rss=1"
David M. GroppeStephan BickelAndrew R. DykstraXiuyuan WangPierre MégevandManuel R. MercierFred A. LadoAshesh D. MehtaChristopher J. Honey2016-08-11doi:10.1101/069179Cold Spring Harbor Laboratory Press2016-08-11
https://biorxiv.org/cgi/content/short/077180v1?rss=1"
C, 27-fold enrichment; p.Tyr427IlefsTer5, 12-fold enrichment). We next sought to use this catalog, of well-established relevance to Mendelian disease, to explore Crohns disease, a common disease with an estimated two to four-fold excess prevalence in AJ. We specifically evaluate whether strong acting rare alleles, enriched by the same founder-effect, contribute excess genetic risk to Crohns disease in AJ, and find that ten rare genetic risk factors in NOD2 and LRRK2 are strongly enriched in AJ, including several novel contributing alleles, show evidence of association to CD. Independently, we find that genomewide common variant risk defined by GWAS shows a strong difference between AJ and non-AJ European control population samples (0.97 s.d. higher, p<10-16). Taken together, the results suggest coordinated selection in AJ population for higher CD risk alleles in general. The results and approach illustrate the value of exome sequencing data in case-control studies along with reference data sets like ExAC to pinpoint genetic variation that contributes to variable disease predisposition across populations.
]]>Manuel Antonio RivasJukka KoskelaHailiang HuangChristine StevensBrandon E AvilaTalin HarituniansBenjamin NealeMitja KurkiAndrea GannaDaniel GrahamBenjamin GlaserInga PeterGil AtzmonNir BarzilaiAdam LevineElena SchiffNikolas PontikosBen WeisburdKonrad J KarczewskiEric MinikelBritt-Sabina PetersenLaurent BeaugeriePhilippe SeksikJacques CosnesStefan SchreiberBernd BokemeyerJohannes BethgeNIDDK IBD Genetics consortiumT2D-GENES consortiumGraham HeapTariq AhmadVincent PlagnolAnthony W SegalStephan TarganDan TurnerPaivi SaavalainenMartti FarkkilaKimmo KontulaMatt2016-09-25doi:10.1101/077180Cold Spring Harbor Laboratory Press2016-09-25
https://biorxiv.org/cgi/content/short/083014v1?rss=1"
Coleman, R. A.Qiao, Z.Singh, S. K.Peng, C. S.Cianfrocco, M.Zhang, Z.Song, L.Piasecka, A.Aldeborgh, H.Basishvili, G.Rice, W.Liu, W.-L.2016-10-24doi:10.1101/083014Cold Spring Harbor Laboratory Press2016-10-24
https://biorxiv.org/cgi/content/short/110544v1?rss=1"
Blouet, C.Burke, L.Darwish, T.Cavanaugh, A.Virtue, S.Roth, E.Moro, J.Liu, S.-M.Xia, J.Dalley, J.Burling, K.Chua, S.Vidal-Puig, T.Schwartz, G.2017-02-22doi:10.1101/110544Cold Spring Harbor Laboratory Press2017-02-22
https://biorxiv.org/cgi/content/short/111682v1?rss=1"
Liu, W.-L.Song, L.Dailey, G.Piasecka, A.Coleman, R. A.2017-08-10doi:10.1101/111682Cold Spring Harbor Laboratory Press2017-08-10
https://biorxiv.org/cgi/content/short/119180v1?rss=1"
Cazettes, F.Fischer, B. J.Beckert, M. V.Pena, J. L.2017-03-22doi:10.1101/119180Cold Spring Harbor Laboratory Press2017-03-22
https://biorxiv.org/cgi/content/short/122465v1?rss=1"
Naumov, A.Kratzer, S.Ting, L.-M.Kim, K.Suvorova, E. S.White, M. W.2017-03-30doi:10.1101/122465Cold Spring Harbor Laboratory Press2017-03-30
https://biorxiv.org/cgi/content/short/131326v1?rss=1"
Zheng, C.Diaz-Cuadros, M.Jao, S. L.Nguyen, K.Hall, D. H.Chalfie, M.2017-04-26doi:10.1101/131326Cold Spring Harbor Laboratory Press2017-04-26
https://biorxiv.org/cgi/content/short/132076v1?rss=1"
Ulahannan, N.Suzuki, M.Simoes-Pires, C. A.Wicik, Z.Wijetunga, N. A.Croken, M. M.Bhattacharyya, S.Johnston, A. D.Kong, Y.Maqbool, S. B.Verma, A.Greally, J. M.2017-04-28doi:10.1101/132076Cold Spring Harbor Laboratory Press2017-04-28
https://biorxiv.org/cgi/content/short/132852v1?rss=1"
Magee, M. J.Sun, Y. V.Brust, J. C.Shah, N. S.Ning, Y.Allana, S.Campbell, A.Hui, Q.Mlisana, K.Moodley, P.Gandhi, N. R.2017-05-03doi:10.1101/132852Cold Spring Harbor Laboratory Press2017-05-03
https://biorxiv.org/cgi/content/short/132886v1?rss=1"
50 km (n=109, 27%). The majority (77%) of participants travelled farther than the recommended distance to a clinic (5 km) and 39% travelled farther than the recommended distance to a hospital (30 km). Nearly half (46%) of participants were diagnosed at a health facility in eThekwini district, of whom, 36% resided outside the Durban metropolitan area.nnConclusionsXDR-TB cases are widely distributed throughout KwaZulu-Natal province with a denser focus in eThekwini district. Patients travelled long distances to the health facility where they were diagnosed with XDR-TB, suggesting a potential role for migration or transportation in the XDR-TB epidemic.
]]>Kapwata, T.Morris, N.Gandhi, N.Campbell, A.Mthiyane, T.Mpangase, P.Nelson, K.Allana, S.Brust, J.Moodley, P.Mlisana, K.Shah, S.2017-05-03doi:10.1101/132886Cold Spring Harbor Laboratory Press2017-05-03
https://biorxiv.org/cgi/content/short/137836v1?rss=1"
Haimovich, G.Ecker, C. M.Dunagin, M. C.Eggan, E.Raj, A.Gerst, J. E.Singer, R. H.2017-05-14doi:10.1101/137836Cold Spring Harbor Laboratory Press2017-05-14
https://biorxiv.org/cgi/content/short/142299v1?rss=1"
Kong, Y.Berko, E. R.Marcketta, A.Maqbool, S. B.Simoes-Pires, C. A.Kronn, D. F.Ye, K. Q.Suzuki, M.Auton, A.Greally, J. M.2017-05-25doi:10.1101/142299Cold Spring Harbor Laboratory Press2017-05-25
https://biorxiv.org/cgi/content/short/142968v1?rss=1"
Wang, P.Zhao, D.Lachman, H.Zheng, D.2017-05-27doi:10.1101/142968Cold Spring Harbor Laboratory Press2017-05-27
https://biorxiv.org/cgi/content/short/148080v1?rss=1"
Kim, B.Emmons, S.2017-06-09doi:10.1101/148080Cold Spring Harbor Laboratory Press2017-06-09
https://biorxiv.org/cgi/content/short/157198v1?rss=1"
Spear, M. L.Hu, D.Pino-Yanes, M.Huntsman, S.Eng, C.Levin, A. M.White, M. J.McGarry, M. E.Thakur, N.Galanter, J. M.Mak, A. C. Y.Oh, S. S.Davis, A.Kumar, R.Farber, H. J.Meade, K.Avila, P. C.Serebrisky, D.Lenoir, M. A.Brigino-Buenaventura, E. A.Rodriquez Cintron, W.Thyne, S. M.Rodriguez-Santana, J. R.Ford, J. G.Chapela, R.Moreno Estrada, A.Sandoval, K.Seibold, M. A.Williams, L. K.Winkler, C. A.Torgerson, D. G.Hernandez, R. D.Burchard, E. G.2017-06-28doi:10.1101/157198Cold Spring Harbor Laboratory Press2017-06-28
https://biorxiv.org/cgi/content/short/157529v1?rss=1"
Tarabra, E.Lee, T.-W. A.Zammit, V. A.Vatish, M.Yamada, E.Pessin, J. E.Bastie, C. C.2017-06-29doi:10.1101/157529Cold Spring Harbor Laboratory Press2017-06-29
https://biorxiv.org/cgi/content/short/167924v1?rss=1"
Lencz, T.Yu, J.Palmer, C.Carmi, S.Ben-Avraham, D.Barzilai, N.Bressman, S.Darvasi, A.Cho, J.Clark, L.Gumus, Z.Joseph, V.Klein, R.Lipkin, S.Offit, K.Ostrer, H.Ozelius, L.Peter, I.Atzmon, G.Pe'er, I.2017-07-24doi:10.1101/167924Cold Spring Harbor Laboratory Press2017-07-24
https://biorxiv.org/cgi/content/short/189084v1?rss=1"
Souza, B.Pavao, R.Belchior, H.Tort, A.2017-09-15doi:10.1101/189084Cold Spring Harbor Laboratory Press2017-09-15
https://biorxiv.org/cgi/content/short/189225v1?rss=1"
Renson, A.Jones, H. E.Beghini, F.Segata, N.Zolnik, C.Usyk, M.Thorpe, L.Burk, R.Waldron, L. D.Dowd, J. B.2017-09-18doi:10.1101/189225Cold Spring Harbor Laboratory Press2017-09-18
https://biorxiv.org/cgi/content/short/191049v1?rss=1"
Clark, J.Meade, M.Ranepura, G.Hall, D. H.Savage-Dunn, C.2017-09-19doi:10.1101/191049Cold Spring Harbor Laboratory Press2017-09-19
https://biorxiv.org/cgi/content/short/193193v1?rss=1"
Suzuki, M.Liao, W.Wos, F.Johnston, A. D.DeGrazia, J.Ishii, J.Bloom, T.Zody, M. C.Germer, S.Greally, J. M.2017-09-24doi:10.1101/193193Cold Spring Harbor Laboratory Press2017-09-24
https://biorxiv.org/cgi/content/short/193201v1?rss=1"
Broderick, M. P.Anderson, A. J.Di Liberto, G. M.Crosse, M. J.Lalor, E. C.2017-09-24doi:10.1101/193201Cold Spring Harbor Laboratory Press2017-09-24
https://biorxiv.org/cgi/content/short/196048v1?rss=1"
Wyss, A. B.Sofer, T.Lee, M. K.Terzikhan, N.Nguyen, J. N.Lahousse, L.Latourelle, J. C.Smith, A. V.Bartz, T. M.Feitosa, M. F.Gao, W.Ahluwalia, T. S.Tang, W.Oldmeadow, C.Duan, Q.de Jong, K.Wojczynski, M. K.Wang, X.-Q.Noordam, R.Hartwig, F. P.Jackson, V. E.Wang, T.Obeidat, M.Hobbs, B. D.Huan, T.Kichaev, G.Jin, J.Graff, M.Harris, T. B.Kalhan, R.Heckbert, S. R.Paternoster, L.Burkart, K. M.Liu, Y.Holliday, E. G.Wilson, J. G.Vonk, J. M.Sanders, J.Barr, R. G.de Mutsert, R.Baptista Menezes, A. M.Adams, H. H. H.van den Be2017-10-05doi:10.1101/196048Cold Spring Harbor Laboratory Press2017-10-05
https://biorxiv.org/cgi/content/short/198580v1?rss=1"
Esmaeili Pourfarhangi, K.Bergman, A.Gligorijevic, B.2017-10-04doi:10.1101/198580Cold Spring Harbor Laboratory Press2017-10-04
https://biorxiv.org/cgi/content/short/2019.12.17.876854v1?rss=1"
Yamada, S.Hinch, A. G.Kamido, H.Zhang, Y.Edelmann, W.Keeney, S.2019-12-17doi:10.1101/2019.12.17.876854Cold Spring Harbor Laboratory Press2019-12-17
https://biorxiv.org/cgi/content/short/2019.12.19.868844v1?rss=1"
Bernard, E.Nannya, Y.Hasserjian, R. P.Devlin, S. M.Tuechler, H.Medina-Martinez, J. S.Yoshizato, T.Shiozawa, Y.Saiki, R.Malcovati, L.Levine, M. F.Arango, J. E.Zhou, Y.Sole, F.Cargo, C. A.Haase, D.Creignou, M.Germing, U.Zhang, Y.Gundem, G.Sarian, A.van de Loosdrecht, A. A.Jadersten, M.Tobiasson, M.Kosmider, O.Follo, M. Y.Thol, F.Pinheiro, R. F.Santini, V.Kotsianidis, I.Boultwood, J.Santos, F. P. S.Schanz, J.Kasahara, S.Ishikawa, T.Tsurumi, H.Takaori-Kondo, A.Kiguchi, T.Polprasert, C.Bennett, J. M.Klimek, V. M.Savon2019-12-19doi:10.1101/2019.12.19.868844Cold Spring Harbor Laboratory Press2019-12-19
https://biorxiv.org/cgi/content/short/2019.12.22.886382v1?rss=1"
Glaunsinger, B.Tucker, J. M.Schaller, A. M.Willis, I. M.2019-12-23doi:10.1101/2019.12.22.886382Cold Spring Harbor Laboratory Press2019-12-23
https://biorxiv.org/cgi/content/short/2019.12.23.885186v1?rss=1"
Chitu, V.Biundo, F.Shlager, G. G. L.Park, E. S.Wang, P.Gulinello, M. E.Gokhan, S.Ketchum, H. C.Saha, K.DeTure, M. A.Dickson, D. W.Wszolek, Z. K.Zheng, D.Croxford, A. L.Becher, B.Sun, D.Mehler, M. F.Stanley, E. R.2019-12-23doi:10.1101/2019.12.23.885186Cold Spring Harbor Laboratory Press2019-12-23
https://biorxiv.org/cgi/content/short/2019.12.23.887224v1?rss=1"
Johnston, A. D.Abdulrazak, A.Sato, H.Maqbool, S.Suzuki, M.Greally, J. M.Simoes-Pires, C. A.2019-12-23doi:10.1101/2019.12.23.887224Cold Spring Harbor Laboratory Press2019-12-23
https://biorxiv.org/cgi/content/short/2019.12.23.887687v1?rss=1"
Bertho, S.Clapp, M.Banisch, T. U.Bandemer, J.Raz, E.Marlow, F.2019-12-27doi:10.1101/2019.12.23.887687Cold Spring Harbor Laboratory Press2019-12-27
https://biorxiv.org/cgi/content/short/2020.01.06.895789v1?rss=1"
Schaller, A.Tucker, J.Willis, I. M.Glaunsinger, B. A.2020-01-06doi:10.1101/2020.01.06.895789Cold Spring Harbor Laboratory Press2020-01-06
https://biorxiv.org/cgi/content/short/2020.01.07.897546v1?rss=1"
Lou, H.Boland, J. F.Torres-Gonzalez, E.Albanez, A.Zhou, W.Steinberg, M.Diaw, L.Mitchell, J.Roberson, D.Cullen, M.Garland, L.Bass, S.Burk, R.Yeager, M.Wentzensen, N.Schiffman, M.Alvirez, E.Gharzouzi, E.Mirabello, L.Dean, M.2020-01-08doi:10.1101/2020.01.07.897546Cold Spring Harbor Laboratory Press2020-01-08
https://biorxiv.org/cgi/content/short/2020.01.08.899773v1?rss=1"
Mayoral, J. A.Shamamian, P.Weiss, L. M.2020-01-09doi:10.1101/2020.01.08.899773Cold Spring Harbor Laboratory Press2020-01-09
https://biorxiv.org/cgi/content/short/2020.01.09.900464v1?rss=1"
Monday, H. R.Bourdenx, M.Jordan, B. A.Castillo, P. E.2020-01-09doi:10.1101/2020.01.09.900464Cold Spring Harbor Laboratory Press2020-01-09
https://biorxiv.org/cgi/content/short/2020.01.09.900563v1?rss=1"
Tovar, D. A.Noel, J.-P.Ishizawa, Y.Patel, S. R.Eskandar, E.Wallace, M. T.2020-01-09doi:10.1101/2020.01.09.900563Cold Spring Harbor Laboratory Press2020-01-09
https://biorxiv.org/cgi/content/short/2020.01.13.904581v1?rss=1"
Lorton, B. M.Harijan, R. K.Burgos, E. S.Bonnano, J. B.Almo, S. C.Shechter, D.2020-01-14doi:10.1101/2020.01.13.904581Cold Spring Harbor Laboratory Press2020-01-14
https://biorxiv.org/cgi/content/short/2020.01.18.911362v1?rss=1"
Johnston, S. T.Parylak, S. L.Kim, S.Mac, N.Lim, C.Gallina, I.Bloyd, C.Newberry, A.Saavedra, C.Novák, O.Goncalves, J. T.Gage, F. H.Shtrahman, M.2020-01-19doi:10.1101/2020.01.18.911362Cold Spring Harbor Laboratory Press2020-01-19
https://biorxiv.org/cgi/content/short/2020.01.24.917260v1?rss=1"
Kosmyna, B.Gupta, V.Query, C. C.2020-01-25doi:10.1101/2020.01.24.917260Cold Spring Harbor Laboratory Press2020-01-25
https://biorxiv.org/cgi/content/short/2020.01.24.918813v1?rss=1"
Herrera, D.Coen-Cagli, R.Gomez-Sena, L.2020-01-25doi:10.1101/2020.01.24.918813Cold Spring Harbor Laboratory Press2020-01-25
https://biorxiv.org/cgi/content/short/2020.02.04.934455v1?rss=1"
Bai, X.Wan, L.Xia, C.2020-02-05doi:10.1101/2020.02.04.934455Cold Spring Harbor Laboratory Press2020-02-05
https://biorxiv.org/cgi/content/short/2020.02.13.944967v1?rss=1"
Zheng, C.Atlas, E.Lee, H. M. T.Jao, S. L. J.Nguyen, K. C. Q.Hall, D. H.Chalfie, M.2020-02-13doi:10.1101/2020.02.13.944967Cold Spring Harbor Laboratory Press2020-02-13
https://biorxiv.org/cgi/content/short/2020.02.19.956656v1?rss=1"
Schwartz-Orbach, L.Zhang, C.Sidoli, S.Amin, R.Kaur, D.Zhebrun, A.Ni, J.Gu, S. G.2020-02-20doi:10.1101/2020.02.19.956656Cold Spring Harbor Laboratory Press2020-02-20
https://biorxiv.org/cgi/content/short/2020.02.20.958272v1?rss=1"
Su, Z.Wu, Y.2020-02-21doi:10.1101/2020.02.20.958272Cold Spring Harbor Laboratory Press2020-02-21
https://biorxiv.org/cgi/content/short/2020.02.25.965772v1?rss=1"
Bortz, R. H.Wong, A. C.Grodus, M. G.Recht, H.Pulanco, M. C.Lasso, G.Anthony, S. J.Mittler, E.Jangra, R. K.Chandran, K.2020-02-26doi:10.1101/2020.02.25.965772Cold Spring Harbor Laboratory Press2020-02-26
https://biorxiv.org/cgi/content/short/2020.03.02.973412v1?rss=1"
Zamith-Miranda, D.Heyman, H. M.Burnet, M. C.Couvillion, S. P.Zheng, X.Munoz, N.Kyle, J. E.Zink, E. M.Weitz, K. K.Bloodsworth, K. J.Clair, G. C.Zucker, J. D.Teuton, J. R.Payne, S. H.Kim, Y.-M.Reyes Gil, M.Baker, E. S.Bredeweg, E. L.Nosanchuk, J. D.Nakayasu, E. S.2020-03-03doi:10.1101/2020.03.02.973412Cold Spring Harbor Laboratory Press2020-03-03
https://biorxiv.org/cgi/content/short/2020.03.15.992685v1?rss=1"
Warren, C.Bonanno, J. B.Almo, S. C.Shechter, D.2020-03-15doi:10.1101/2020.03.15.992685Cold Spring Harbor Laboratory Press2020-03-15
https://biorxiv.org/cgi/content/short/2020.03.19.999508v1?rss=1"
Baker, L. A.Tar, M.Villegas, G.Charafeddine, R.Kramer, A.Vafaeva, O.Nacharaju, P.Friedman, J.Davies, K.Sharp, D.2020-03-20doi:10.1101/2020.03.19.999508Cold Spring Harbor Laboratory Press2020-03-20
https://biorxiv.org/cgi/content/short/2020.03.20.001032v1?rss=1"
Gabbay, V.Liu, Q.DeWitt, S. J.Mehra, L. M.Alonso, C. M.Ely, B. A.2020-03-23doi:10.1101/2020.03.20.001032Cold Spring Harbor Laboratory Press2020-03-23
https://biorxiv.org/cgi/content/short/2020.03.21.001602v1?rss=1"
Chen, K.Cho, S. Y.Zhang, Y.Beck, A.Segall, J. E.2020-03-23doi:10.1101/2020.03.21.001602Cold Spring Harbor Laboratory Press2020-03-23
https://biorxiv.org/cgi/content/short/2020.03.26.009522v1?rss=1"
Romano, S.Kaufman, O. H.Marlow, F.2020-03-26doi:10.1101/2020.03.26.009522Cold Spring Harbor Laboratory Press2020-03-26
https://biorxiv.org/cgi/content/short/2020.03.31.018747v1?rss=1"
Selyutina, A.Persaud, M.Lee, K.KewalRamani, V.Diaz-Griffero, F.2020-04-01doi:10.1101/2020.03.31.018747Cold Spring Harbor Laboratory Press2020-04-01
https://biorxiv.org/cgi/content/short/2020.04.03.024042v1?rss=1"
Rocchi, F.Oya, H.Balezeau, F.Billig, A. J.Kocsis, Z.Jenison, R.Nourski, K. V.Kovach, C. K.Steinschneider, M.Kikuchi, Y.Rhone, A. E.Dlouhy, B. J.Kawasaki, H.Adolphs, R.Greenlee, J. D. W.Griffiths, T. D.Howard, M. A.Petkov, C. I.2020-04-05doi:10.1101/2020.04.03.024042Cold Spring Harbor Laboratory Press2020-04-05
https://biorxiv.org/cgi/content/short/2020.04.06.027540v1?rss=1"
McCutcheon, S.Stout, R. F.Spray, D. C.2020-04-07doi:10.1101/2020.04.06.027540Cold Spring Harbor Laboratory Press2020-04-07
https://biorxiv.org/cgi/content/short/2020.04.14.041335v1?rss=1"
Rougerie, P.Cox, D.2020-04-15doi:10.1101/2020.04.14.041335Cold Spring Harbor Laboratory Press2020-04-15
https://biorxiv.org/cgi/content/short/2020.04.14.041483v1?rss=1"
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View larger version (28K):
org.highwire.dtl.DTLVardef@728d5eorg.highwire.dtl.DTLVardef@9f2e24org.highwire.dtl.DTLVardef@8e7011org.highwire.dtl.DTLVardef@15f8d33_HPS_FORMAT_FIGEXP M_FIG Graphical abstract depicting the consequential adverse downregulation of Succinate Dehydrogenase in ccRCC and its central role in oxidative phosphorylation
C_FIG
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60% of circulating tumor cells. Mechanistically, stemness is induced in non-stem cancer cells upon their direct contact with macrophages via Notch signaling. In breast cancers from patients, the density of TMEM doorways correlates strongly with the proportion of cancer cells expressing stem cell markers, indicating that in human breast cancer TMEM doorways are not only cancer cell intravasation portals but also CSC programming sites.
One Sentence SummaryIntravital imaging reveals macrophage-mediated induction of cancer stem cells in vivo and their dramatic enrichment on dissemination through TMEM doorways.
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Lam, A. J.Rao, L.Anazawa, Y.Okada, K.Chiba, K.Niwa, S.Gennerich, A.Nowakowski, D. W.McKenney, R. J.2020-09-22doi:10.1101/2020.09.22.308320Cold Spring Harbor Laboratory Press2020-09-22
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Selyutina, A.Simons, L. M.Bulnes-Ramos, A.Hultquist, J. F.Diaz-Griffero, F.2020-09-29doi:10.1101/2020.09.29.318121Cold Spring Harbor Laboratory Press2020-09-29
https://biorxiv.org/cgi/content/short/2020.10.01.322594v1?rss=1"
Bielinski, V. A.Brunson, J. K.Ghosh, A.Moosburner, M. A.Garza, E. A.Fussy, Z.Bai, J.McKinnie, S. M. K.Moore, B.Allen, A. E.Almo, S. C.Dupont, C. L.2020-10-02doi:10.1101/2020.10.01.322594Cold Spring Harbor Laboratory Press2020-10-02
https://biorxiv.org/cgi/content/short/2020.10.04.325787v1?rss=1"
Emiliano, A. B.He, Y.Higuchi, S.Lopatinsky, N.Nemr, R.Schwartz, G. J.2020-10-05doi:10.1101/2020.10.04.325787Cold Spring Harbor Laboratory Press2020-10-05
https://biorxiv.org/cgi/content/short/2020.10.05.326785v1?rss=1"
0.05). SWM group had a significantly lower cumulative food intake throughout the study, except for week 1 (p<0.01). Glucose tolerance was only demonstrably better in the SG group compared to SH group at 8 weeks post-operatively (p<0.01). Plasma leptin was significantly lower in the SG group compared to both SWM and SH groups group by the second post-operative month (p<0.01), in spite of SGs increasing fat mass accumulation. In the second post-operative month, both FGF-21 and GDF-15 were increased in the SH group compared to the SG and SWM groups (p<0.05), while there was no difference in plasma insulin among the three groups. Heat production was surprisingly higher in the SH group compared to the other two groups (p<0.05), even though brown adipose tissue Peroxisome Proliferator-Activated Receptor Gamma (PPARg) and Cidea mRNA expression were significantly higher in SG and SWM compared to SH (p<0.01). There was no change in BAT UCP-1 mRNA expression among the groups (p>0.05). There was also no change in fecal lipid content among the groups (p>0.05).
ConclusionsSG in obese, middle aged male mice leads is accompanied by fat mass regain in the second post-operative month, while plasma leptin levels continue to be significantly lower. This raises the question of whether the observed fat mass regain consists mostly of visceral adipose tissue.
]]>Emiliano, A.He, Y.Higuchi, S.Nemr, R.Lopatinsky, N.Schwartz, G. J.2020-10-07doi:10.1101/2020.10.05.326785Cold Spring Harbor Laboratory Press2020-10-07
https://biorxiv.org/cgi/content/short/2020.10.09.324939v1?rss=1"
Hatch, H. A. M.Belalcazar, H. M.Marshall, O. J.Secombe, J.2020-10-09doi:10.1101/2020.10.09.324939Cold Spring Harbor Laboratory Press2020-10-09
https://biorxiv.org/cgi/content/short/2020.10.12.331975v1?rss=1"
Li, Z.Mi, S.Osagie, O. I.Ji, J.Yang, C.-P. H.Schwartz, M.Hui, P.Huang, G. S.2020-10-12doi:10.1101/2020.10.12.331975Cold Spring Harbor Laboratory Press2020-10-12
https://biorxiv.org/cgi/content/short/2020.10.12.335711v1?rss=1"
Secombe, J.Belalcazar, H. M.Hicks, E. L.Zamurrad, S.Liebl, F. L. W.2020-10-12doi:10.1101/2020.10.12.335711Cold Spring Harbor Laboratory Press2020-10-12
https://biorxiv.org/cgi/content/short/2020.10.14.338954v1?rss=1"
View larger version (26K):
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]]>Luengo, E.Trigo-Alonso, P.Fernandez-Mendivil, C.Nunez, A.del Campo, M.Porrero, C.Garcia-Magro, N.Negredo, P.Sanchez, C.Bernal, J. A.Rabano, A.Hoozemans, J.Casas, A. I.Schmidt, H. H.Cuervo, A. M.Lopez, M. G.2020-10-14doi:10.1101/2020.10.14.338954Cold Spring Harbor Laboratory Press2020-10-14
https://biorxiv.org/cgi/content/short/2020.10.22.349514v1?rss=1"
Nobre, A. R.Risson, E.Singh, D. K.Di Martino, J. S.Cheung, J. F.Wang, J.Johnson, J.Russnes, H. G.Bravo-Cordero, J. J.Birbrair, A.Naume, B.Azhar, M.Frenette, P. S.Aguirre-Ghiso, J. A.2020-10-22doi:10.1101/2020.10.22.349514Cold Spring Harbor Laboratory Press2020-10-22
https://biorxiv.org/cgi/content/short/2020.10.22.351403v1?rss=1"
Bertho, S.Kaufman, O.Lee, K.Santos-Ledo, A.Dellal, D.Marlow, F. L.2020-10-23doi:10.1101/2020.10.22.351403Cold Spring Harbor Laboratory Press2020-10-23
https://biorxiv.org/cgi/content/short/2020.10.23.352377v1?rss=1"
Makani, S.Lutzu, S.Lituma, P. J.Hunt, D. L.Castillo, P. E.2020-10-24doi:10.1101/2020.10.23.352377Cold Spring Harbor Laboratory Press2020-10-24
https://biorxiv.org/cgi/content/short/2020.10.29.359851v1?rss=1"
Wang, L.Liu, Y.Stratigopoulos, G.Panigrahi, S.Sui, L.Leduc, C. A.Glover, H. J.De Rosa, M. C.Burnett, L. C.Williams, D. J.Shang, L.Goland, R.Tsang, S. H.Wardlaw, S.Egli, D.Zheng, D.Doege, C. A.Leibel, R. L.2020-10-29doi:10.1101/2020.10.29.359851Cold Spring Harbor Laboratory Press2020-10-29
https://biorxiv.org/cgi/content/short/2020.11.02.365783v1?rss=1"
Donoso, M.Speranza, L.Kalinowska, M.Castillo, C.De Sanctis, C.Francesconi, A.2020-11-02doi:10.1101/2020.11.02.365783Cold Spring Harbor Laboratory Press2020-11-02
https://biorxiv.org/cgi/content/short/2020.11.04.368472v1?rss=1"
Zamith-Miranda, D.Heyman, H. M.Couvillion, S. P.Cordero, R. J. B.Rodrigues, M.Nimrichter, L.Casadevall, A.Amatuzzi, R.Alves, L. R.Nakayasu, E. S.Nosanchuk, J. D.2020-11-04doi:10.1101/2020.11.04.368472Cold Spring Harbor Laboratory Press2020-11-04
https://biorxiv.org/cgi/content/short/2020.11.05.369827v1?rss=1"
Sokoloski, S.Aschner, A.Coen-Cagli, R.2020-11-06doi:10.1101/2020.11.05.369827Cold Spring Harbor Laboratory Press2020-11-06
https://biorxiv.org/cgi/content/short/2020.11.08.371922v1?rss=1"
Alquezar, C.Schoch, K. M.Geier, E. G.Ramos, E. M.Scrivo, A.Li, K.Argouarch, A. R.Mlynarski, E. E.Dombroski, B.Yokoyama, J. S.Cuervo, A. M.Burlingame, A. L.Schellenberg, G. D.Miller, T. M.Miller, B. L.Kao, A. W.2020-11-08doi:10.1101/2020.11.08.371922Cold Spring Harbor Laboratory Press2020-11-08
https://biorxiv.org/cgi/content/short/2020.11.11.378331v1?rss=1"
Wu, Y.Dhusia, K.Su, Z.2020-11-11doi:10.1101/2020.11.11.378331Cold Spring Harbor Laboratory Press2020-11-11
https://biorxiv.org/cgi/content/short/2020.11.11.378497v1?rss=1"
Chi, Y.Youn, D. Y.Xiaoli, A. M.Liu, L.Pessin, J. B.Yang, F.Pessin, J. E.2020-11-11doi:10.1101/2020.11.11.378497Cold Spring Harbor Laboratory Press2020-11-11
https://biorxiv.org/cgi/content/short/2020.11.11.378570v1?rss=1"
Nie, L.Pike, A. C.Pascoa, T. C.Bushell, S. R.Quigley, A.Ruda, G. F.Chu, A.Cole, V.Speedman, D.Moreira, T.Shrestha, L.Mukhopadhyay, S. M.Burgess-Brown, N. A.Love, J. D.Brennan, P. E.Carpenter, E. P.2020-11-11doi:10.1101/2020.11.11.378570Cold Spring Harbor Laboratory Press2020-11-11
https://biorxiv.org/cgi/content/short/2020.11.11.378893v1?rss=1"
Raiders, S.Black, E. C.Bae, A.MacFarlane, S.Shaham, S.Singhvi, A.2020-11-12doi:10.1101/2020.11.11.378893Cold Spring Harbor Laboratory Press2020-11-12
https://biorxiv.org/cgi/content/short/2020.11.13.381756v1?rss=1"
View larger version (40K):
org.highwire.dtl.DTLVardef@12d0989org.highwire.dtl.DTLVardef@1cd1eb2org.highwire.dtl.DTLVardef@19a56caorg.highwire.dtl.DTLVardef@1b7f3e1_HPS_FORMAT_FIGEXP M_FIG C_FIG
]]>Agrawal, R. R.Larrea, D.Shi, L.Song, D.Xu, Y.Yun, T. D.Emmanuele, V.Cummins, L. G.Macaluso, F. P.Kernie, S. G.Min, W.Deckelbaum, R. J.Area-Gomez, E.2020-11-15doi:10.1101/2020.11.13.381756Cold Spring Harbor Laboratory Press2020-11-15
https://biorxiv.org/cgi/content/short/2020.11.17.386821v1?rss=1"
Bilacchi, C. M.Sirius, E. V. P.Cravo, A. M.de Azevedo Neto, R. M.2020-11-19doi:10.1101/2020.11.17.386821Cold Spring Harbor Laboratory Press2020-11-19
https://biorxiv.org/cgi/content/short/2020.11.17.386854v1?rss=1"
Hülsemann, M.Donnelly, S. K.Verkhusha, P. V.Mao, S. S. P. H.Segall, J. E.Hodgson, L.2020-11-17doi:10.1101/2020.11.17.386854Cold Spring Harbor Laboratory Press2020-11-17
https://biorxiv.org/cgi/content/short/2020.11.18.389288v1?rss=1"
Maron, M. I.Burgos, E. S.Gupta, V.Casill, A. D.Kosmyna, B.Chen, H.Gamble, M. J.Query, C. C.Shechter, D.2020-11-19doi:10.1101/2020.11.18.389288Cold Spring Harbor Laboratory Press2020-11-19
https://biorxiv.org/cgi/content/short/2020.11.23.394296v1?rss=1"
2000 associations at P<1x10-9, implicating specific blood cell-types, transcription factors and causal genes. The vast majority of these associations are captured by variants identified in large genome-wide association studies (GWAS) for blood-cell traits. find-tfbs is computationally efficient and robust, allowing for the rapid identification of non-coding variants associated with multiple human phenotypes in very large sample size.
Availabilityhttps://github.com/Helkafen/find-tfbs and https://github.com/Helkafen/find-tfbs-demo
Contactssebastian.meric.de.bellefon@umontreal.ca and guillaume.lettre@umontreal.ca
Supplementary informationSupplementary data are available.
]]>Meric de Bellefon, S.Thibord, F.Auer, P. L.Blangero, J.Coban-Akdemir, Z. H.Floyd, J. S.Fornage, M.Johnsen, J. M.Lange, L. A.Lewis, J. P.Mathias, R. A.McHugh, C. P.Moon, J.-Y.Reiner, A. P.Stilp, A. M.NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium,Lettre, G.2020-11-23doi:10.1101/2020.11.23.394296Cold Spring Harbor Laboratory Press2020-11-23
https://biorxiv.org/cgi/content/short/2020.11.24.396390v1?rss=1"
Sharma, V. P.Williams, J.Leung, E.Sanders, J.Eddy, R.Castracane, J.Oktay, M. H.Entenberg, D.Condeelis, J. S.2020-11-24doi:10.1101/2020.11.24.396390Cold Spring Harbor Laboratory Press2020-11-24
https://biorxiv.org/cgi/content/short/2020.11.25.395806v1?rss=1"
Zhou, X.Vachon, C.Cizeron, M.Romatif, O.Buelow, H.Jospin, M.Bessereau, J.-L.2020-11-26doi:10.1101/2020.11.25.395806Cold Spring Harbor Laboratory Press2020-11-26
https://biorxiv.org/cgi/content/short/2020.11.25.397596v1?rss=1"
Nagajyothi, J. F.Lizardo, K.Ayyappan, J. P.Oswal, N.Weiss, L. M.Scherer, P. E.2020-11-26doi:10.1101/2020.11.25.397596Cold Spring Harbor Laboratory Press2020-11-26
https://biorxiv.org/cgi/content/short/2020.11.30.404178v1?rss=1"
Poulikova, K.Zuvalova, I.Vyhlidalova, B.Krasulova, K.Jiskrova, E.Vrzal, R.Kortagere, S.Kopecna, M.Kopecny, D.Sebela, M.Rolfes, K. M.Haarmann-Stemmann, T.Mani, S.Dvorak, Z.2020-12-01doi:10.1101/2020.11.30.404178Cold Spring Harbor Laboratory Press2020-12-01
https://biorxiv.org/cgi/content/short/2020.12.03.410696v1?rss=1"
Lasseigne, A. M.Echeverry, F. A. A.Ijaz, S.Michel, J. C.Martin, E. A.Marsh, A. J.Trujillo, E.Marsden, K. C.Pereda, A. E.Miller, A. C.2020-12-04doi:10.1101/2020.12.03.410696Cold Spring Harbor Laboratory Press2020-12-04
https://biorxiv.org/cgi/content/short/2020.12.04.411843v1?rss=1"
Zamith Miranda, D.Amatuzzi, R. F.Martins, S. T.Vieira, A. Z.Munhoz da Rocha, I. F.Rodrigues, M.Trentin, G.Almeida, F.Nakayasu, E. S.Nosanchuk, J. D.Alves, L. R.2020-12-05doi:10.1101/2020.12.04.411843Cold Spring Harbor Laboratory Press2020-12-05
https://biorxiv.org/cgi/content/short/2020.12.04.412593v1?rss=1"
Ames, K.Kaur, I.Shi, Y.Tong, M. M.Sinclair, T.Hemmati, S.Glushakow-Smith, S. G.Tein, E. E.Gurska, L.Dubin, R.Shan, J.Pradhan, K.Verma, A.Montagna, C.Gritsman, K.2020-12-06doi:10.1101/2020.12.04.412593Cold Spring Harbor Laboratory Press2020-12-06
https://biorxiv.org/cgi/content/short/2020.12.09.418590v1?rss=1"
Batista-Brito, R.Majumdar, A.Nuno, A.Vinck, M.Cardin, J. A.2020-12-10doi:10.1101/2020.12.09.418590Cold Spring Harbor Laboratory Press2020-12-10
https://biorxiv.org/cgi/content/short/2020.12.09.418657v1?rss=1"
Merheb, E.Cui, M.-H.DuBois, J. C.Branch, C. A.Gulinello, M.Shafit-Zagardo, B.Moir, R. D.Willis, I. M.2020-12-10doi:10.1101/2020.12.09.418657Cold Spring Harbor Laboratory Press2020-12-10
https://biorxiv.org/cgi/content/short/2020.12.14.421529v1?rss=1"
Foox, J.Nordlund, J.Lalancette, C.Gong, T.Lacey, M.Lent, S.Langhorst, B. W.Ponnaluri, V. K. C.Williams, L.Padmamabhan, K.Cavalcante, R. G.Lundmark, A.Butler, D.Gurvitch, J. M.Greally, J. M.Suzuki, M.Menor, M.Nasu, M.Alonso, A.Sheridan, C.Scherer, A.Bruinsma, S.Golda, G.Muszynska, A.Łabaj, P. P.Campbell, M. A.Wos, F.Raine, A.Liljedahl, U.Axelsson, T.Wang, C.Chen, Z.Yang, Z.Li, J.Yang, X.Wang, H.Melnick, A.Guo, S.Blume, A.Franke, V.Ibanez de Caceres, I.Rodriguez-Antolin, C.Rosas, R.Davis, J. W.Ishii, J.Megh2020-12-14doi:10.1101/2020.12.14.421529Cold Spring Harbor Laboratory Press2020-12-14
https://biorxiv.org/cgi/content/short/2020.12.16.422727v1?rss=1"
Su, H.Jiang, M.Senevirathne, C.Aluri, S.Zhang, T.Guo, H.Xavier-Ferrucio, J.Jin, S.Tran, N.-T.Liu, S.-M.Sun, C.-W.Zhu, Y.Zhao, Q.Chen, Y.Cable, L.Shen, Y.Liu, J.Qu, C.-K.Han, X.Klug, C. A.Bhatia, R.Chen, Y.Nimer, S. D.Zheng, Y. G.Iancu-Rubin, C.Jin, J.Deng, H.Krause, D. S.Xiang, J.Verma, A.Luo, M.Zhao, X.2020-12-16doi:10.1101/2020.12.16.422727Cold Spring Harbor Laboratory Press2020-12-16
https://biorxiv.org/cgi/content/short/2020.12.22.423783v1?rss=1"
170,000 individuals from multiple ancestries: 97,493 European, 30,025 South Asian, 16,507 African, 16,440 Hispanic/Latino, 10,420 East Asian, and 1,182 Samoan. We identified 35 genes associated with circulating lipid levels. Ten of these: ALB, SRSF2, JAK2, CREB3L3, TMEM136, VARS, NR1H3, PLA2G12A, PPARG and STAB1 have not been implicated for lipid levels using rare coding variation in population-based samples. We prioritize 32 genes identified in array-based genome-wide association study (GWAS) loci based on gene-based associations, of which three: EVI5, SH2B3, and PLIN1, had no prior evidence of rare coding variant associations. Most of the associated genes showed evidence of association in multiple ancestries. Also, we observed an enrichment of gene-based associations for low-density lipoprotein cholesterol drug target genes, and for genes closest to GWAS index single nucleotide polymorphisms (SNP). Our results demonstrate that gene-based associations can be beneficial for drug target development and provide evidence that the gene closest to the array-based GWAS index SNP is often the functional gene for blood lipid levels.
]]>Hindy, G.Dornbos, P.Chaffin, M. D.Liu, D. J.Wang, M. X.Aguilar-Salinas, C. A.Antonacci-Fulton, L.Ardissino, D.Arnett, D. K.Aslibekyan, S.Atzmon, G.Ballantyne, C. M.Barajas-Olmos, F.Barzilai, N.Becker, L. C.Bielak, L. F.Bis, J. C.Blangero, J.Boerwinkle, E.Bonnycastle, L. L.Bottinger, E.Bowden, D. W.Bown, M. J.Brody, J. A.Broome, J. G.Burtt, N. P.Cade, B. E.Centeno-Cruz, F.Chan, E.Chang, Y.-C.Chen, Y.-D. I.Cheng, C.-Y.Choi, W. J.Chowdhury, R.Contreras-Cubas, C.Cordova, E. J.Correa, A.Cupples, L. A.Curran, J. E.Danesh,2020-12-23doi:10.1101/2020.12.22.423783Cold Spring Harbor Laboratory Press2020-12-23
https://biorxiv.org/cgi/content/short/2020.12.24.424342v1?rss=1"
Nomaru, H.Liu, Y.De Bono, C.Righelli, D.Cirino, A.Wang, W.Racedo, S. E.Dantas, A.Cai, C.Angelini, C.Christiaen, L.Kelly, R.Baldini, A.Zheng, D.Morrow, B. E.2020-12-24doi:10.1101/2020.12.24.424342Cold Spring Harbor Laboratory Press2020-12-24
https://biorxiv.org/cgi/content/short/2020.12.28.424504v1?rss=1"
Cibelli, A.Lopez-Quintero, S. V.McCutcheon, S.Scemes, E.Spray, D. C.Stout, R. F.Suadicani, S. O.Thi, M. M.Urban-Maldonado, M.2020-12-29doi:10.1101/2020.12.28.424504Cold Spring Harbor Laboratory Press2020-12-29
https://biorxiv.org/cgi/content/short/2020.12.30.424861v1?rss=1"
Dieterle, M. E.Sola-Riera, C.Jangra, R. K.Ye, C.Goodfellow, S. M.Mittler, E.Kasikci, E.Bradfute, S. B.Klingström, J.Chandran, K.2021-01-04doi:10.1101/2020.12.30.424861Cold Spring Harbor Laboratory Press2021-01-04
https://biorxiv.org/cgi/content/short/2021.01.05.425447v1?rss=1"
View larger version (19K):
org.highwire.dtl.DTLVardef@17151cborg.highwire.dtl.DTLVardef@b0f480org.highwire.dtl.DTLVardef@184166corg.highwire.dtl.DTLVardef@dc177d_HPS_FORMAT_FIGEXP M_FIG C_FIG Overview of MAVERICC. Conceptual overview of the approach outlined in this manuscript. To make VACV recombinants, the parental virus is first purified and vDNA is isolated with phenol:chloroform extraction. This purified vDNA is then treated with Cas9 enzyme and sgRNAs that are directed to a specific locus in the VACV genome. The cleaved vDNA is then transfected into FWPV-infected BSC-40 cells along with a transfer amplicon containing an insertion or mutation of interest flanked by homologous sequences. Recombination is allowed to occur for 5-7 days, during which time the cleaved vDNA is healed by the transfer amplicon, thus editing the VACV genome, and packaged into infectious viral particles. Individual plaques are grown up and rVACVs are isolated after a single round of plaque purification. Image was created with Biorender.com.
]]>Laudermilch, E.Chandran, K.2021-01-05doi:10.1101/2021.01.05.425447Cold Spring Harbor Laboratory Press2021-01-05
https://biorxiv.org/cgi/content/short/2021.01.12.425739v1?rss=1"
Levcik, D.Sugi, A. H.Pochapski, J. A.Baltazar, G.Pulido, L. N.Villas-Boas, C.Aguilar-Rivera, M.Fuentes-Flores, R.Nicola, S. M.Da Cunha, C.2021-01-12doi:10.1101/2021.01.12.425739Cold Spring Harbor Laboratory Press2021-01-12
https://biorxiv.org/cgi/content/short/2021.01.14.426721v1?rss=1"
Gomari, D. P.Schweickart, A.Cerchietti, L.Paietta, E.Fernandez, H.Al-Amin, H.Suhre, K.Krumsiek, J.2021-01-17doi:10.1101/2021.01.14.426721Cold Spring Harbor Laboratory Press2021-01-17
https://biorxiv.org/cgi/content/short/2021.01.21.427696v1?rss=1"
Honorato, L.Demetrio, J. F.Ellis, C. C.Piffer, A. C.Pereira, Y.Frases, S.Araujo, G.Pontes, B.Mendes, M. T.Pereira, M. D.Guimaraes, A. J.da Silva, N. M.Vargas, G.Joffe, L.Del Poeta, M.Nosanchuk, J. D.Zamith Miranda, D.Reis, F.Rodrigues, M. L.Martins, S.Alves, L. R.Almeida, I. C.Nimrichter, L.2021-01-22doi:10.1101/2021.01.21.427696Cold Spring Harbor Laboratory Press2021-01-22
https://biorxiv.org/cgi/content/short/2021.01.25.428086v1?rss=1"
Longchamps, R. J.Yang, S. Y.Castellani, C. A.Shi, W.Lane, J.Grove, M. L.Bartz, T. M.Sarnowski, C.Burrows, K.Guyatt, A. L.Gaunt, T. R.Kacprowski, T.Yang, J.De, P. L.Yu, L.CHARGE Aging and Longevity Group,Bergman, A.Xia, R.Fornage, M.Feitosa, M. F.Wojczynski, M. K.Kraja, A. T.Province, M. A.Amin, N.Rivadeneira, F.Tiemeier, H.Uitterlinden, A. G.Broer, L.Van, J.Van, C.Raffield, L. M.Lange, L.Rich, S. S.Lemaitre, R. N.Goodarzi, M. O.Sitlani, C. M.Mak, A. C.Bennett, D. A.Rodriguez, S.Murabito, J. M.Lunetta, K. L.Soto2021-01-28doi:10.1101/2021.01.25.428086Cold Spring Harbor Laboratory Press2021-01-28
https://biorxiv.org/cgi/content/short/2021.01.28.428713v1?rss=1"
Casill, A. D.Haimowitz, A. J.Kosmyna, B.Query, C. C.Ye, K.Gamble, M. J.2021-01-29doi:10.1101/2021.01.28.428713Cold Spring Harbor Laboratory Press2021-01-29
https://biorxiv.org/cgi/content/short/2021.02.02.429412v1?rss=1"
Carbonell, A. U.Freire-Cobo, C.Deyneko, I. V.Erdjument-Bromage, H.Clipperton-Allen, A.Rasmusson, R.Page, D. T.Neubert, T. A.Jordan, B. A.2021-02-02doi:10.1101/2021.02.02.429412Cold Spring Harbor Laboratory Press2021-02-02
https://biorxiv.org/cgi/content/short/2021.02.08.430346v1?rss=1"
Semedo, J.Jasper, A. I.Zandvakili, A.Aschner, A.Machens, C.Kohn, A.Yu, B. M.2021-02-10doi:10.1101/2021.02.08.430346Cold Spring Harbor Laboratory Press2021-02-10
https://biorxiv.org/cgi/content/short/2021.02.10.430690v1?rss=1"
Zhou, J.Flores-Bellver, M.Pan, J.Benito-Martin, A.Shi, C.Onwumere, O.Mighty, J.Qian, J.Zhong, X.Hogue, T.Amponsah-Antwi, B.Einbond, L.Gharbaran, R.Wu, H.Chen, B.-J.Zheng, Z.Tchaikovskaya, T.Zhang, X.Peinado, H.Canto-Soler, V.Redenti, S.2021-02-11doi:10.1101/2021.02.10.430690Cold Spring Harbor Laboratory Press2021-02-11
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Chen, P.Zheng, F.Li, S.Cheng, H.Bornhorst, J.Li, Y.Yang, B.Lee, K. H.Ke, T.Schwerdtle, T.Yang, X.Bowman, A. B.Aschner, M.2021-02-22doi:10.1101/2021.02.18.431924Cold Spring Harbor Laboratory Press2021-02-22
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Fouracre, J. P.He, J.Chen, V. J.Sidoli, S.Poethig, R. S.2021-02-24doi:10.1101/2021.02.23.432516Cold Spring Harbor Laboratory Press2021-02-24
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Dickey, C. W.Verzhbinsky, I. A.Jiang, X.Rosen, B. Q.Kajfez, S.Stedelin, B.Shih, J. J.Ben-Haim, S.Raslan, A. M.Madsen, J. R.Eskandar, E. N.Gonzalez-Martinez, J.Cash, S. S.Halgren, E.2021-02-24doi:10.1101/2021.02.23.432582Cold Spring Harbor Laboratory Press2021-02-24
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Krzyspiak, J.Yan, J.Ghosh, H.Galinski, B.Lituma, P. J.Alvina, K.Washburn, S.Gronska-Peski, M.Tai, Y. D.McDermott, K.Zukin, S.Weiser, D.Castillo, P. E.Khodakhah, K.Hebert, J.2021-02-28doi:10.1101/2021.02.27.433204Cold Spring Harbor Laboratory Press2021-02-28
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Boutet, M.Benet, Z.Guillen, E.Koch, C.SOUDJA, S. M.Delahaye, F.Fooksman, D.Lauvau, G.2021-03-02doi:10.1101/2021.03.01.433468Cold Spring Harbor Laboratory Press2021-03-02
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Chaudrhy, N.Sica, M.Surabhi, S.Sanchez Hernandez, D.Mesquita, A.Selimovic, A.Riaz, A.Bai, H.Macintosh, G. C.Jenny, A.2021-03-03doi:10.1101/2021.03.03.432938Cold Spring Harbor Laboratory Press2021-03-03
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Ramnauth, A. D.Maynard, K.Kardian, A. S.Phan, B. N.Tippani, M.Rajpurohit, S.Hobbs, J. W.Page, S. C.Jaffe, A. E.Martinowich, K.2021-03-04doi:10.1101/2021.03.04.433962Cold Spring Harbor Laboratory Press2021-03-04
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ji, z.Chuen, J.Kiparaki, M.baker, n. e.2021-03-06doi:10.1101/2021.03.05.433802Cold Spring Harbor Laboratory Press2021-03-06
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Kunnath-Velayudhan, S.Ng, T. W.Saini, N. K.Goldberg, M. F.Arora, P.Xu, J.Kim, J.Herold, B. C.Chan, J.Jacobs, W. R.Porcelli, S. A.2021-03-08doi:10.1101/2021.03.07.434271Cold Spring Harbor Laboratory Press2021-03-08
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Wang, Y.Eddison, M.Fleishman, G.Weigert, M.Xu, S.Henry, F. E.Wang, T.Lemire, A. L.Schmidt, U.Yang, H.Rokicki, K.Goina, C.Svoboda, K.Myers, E. W.Saalfeld, S.Korff, W.Sternson, S. M.Tillberg, P. W.2021-03-08doi:10.1101/2021.03.08.434304Cold Spring Harbor Laboratory Press2021-03-08
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Tang, L.Trivedi, M.Freund, J.Salazar, C.Ramirez-Suarez, N.Lee, G.Rahman, M.Wang, Y.Grant, B.Bülow, H. E.2021-03-10doi:10.1101/2021.03.10.434729Cold Spring Harbor Laboratory Press2021-03-10
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Gupta, P.Thomas, S. E.Cory-Wright, J.Sebastián-Pérez, V.Burgess, A.Cattermole, E.Meghir, C.Abell, C.Coyne, A. G.Jacobs, W. R.Blundell, T. L.Tiwari, S.Mendes, V.2021-03-12doi:10.1101/2021.03.12.435067Cold Spring Harbor Laboratory Press2021-03-12
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Carnesecchi, J.Boumpas, P.van Nierop y Sanchez, P.Domsch, K.Pinto, H. D.Borges Pinto, P.Lohmann, I.2021-03-25doi:10.1101/2021.03.25.434787Cold Spring Harbor Laboratory Press2021-03-25
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Ramos, E. I.Yang, B.Vasquez, Y. M.Lin, K. Y.Choudhari, R.Gadad, S. S.2021-03-28doi:10.1101/2021.03.26.437262Cold Spring Harbor Laboratory Press2021-03-28
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Hiramoto, T.Sumiyoshi, A.Yamauchi, T.Tanigaki, K.Shi, Q.Kang, G.Ryoke, R.Nonaka, H.Enomoto, S.Izumi, T.Bhat, M. A.Kawashima, R.Hiroi, N.2021-03-30doi:10.1101/2021.03.29.437581Cold Spring Harbor Laboratory Press2021-03-30
https://biorxiv.org/cgi/content/short/2021.03.31.437836v1?rss=1"
Vadovics, M.Igaz, N.Alfoldi, R.Rakk, D.Veres, E.Szucs, B.Horvath, M.Toth, R.Szucs, A.Horvath, P.Tiszlavicz, L.Vagvolgyi, C.Nosanchuk, J.Szekeres, A.Kiricsi, M.Puskas, L.Gacser, A.2021-03-31doi:10.1101/2021.03.31.437836Cold Spring Harbor Laboratory Press2021-03-31
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Sato, H.Singer, R. H.2021-03-31doi:10.1101/2021.03.31.437867Cold Spring Harbor Laboratory Press2021-03-31
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Nepali, P. R.Mathieu, M.Kitz, S.Nakauchi, C.Gabriels, K.Russell, J.Monette, S.te Poele, J. A.Heeneman, S.Rimner, A.Qiu, Y.Kurland, I. J.Stewart, F. A.Jaimes, E. A.Haimovitz-Friedman, A.2021-04-09doi:10.1101/2021.04.08.438992Cold Spring Harbor Laboratory Press2021-04-09
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Alves, B. R.Sutti, R.Silva, P. I.Bertani, R.Santos-Junior, J. G.Rocha e Silva, T. A.Linardi, A.2021-04-14doi:10.1101/2021.04.13.439720Cold Spring Harbor Laboratory Press2021-04-14
https://biorxiv.org/cgi/content/short/2021.04.20.440666v1?rss=1"
Hajnal, M. A.Tran, D.Einstein, M.Martelo, M. V.Safaryan, K.Polack, P.-O.Golshani, P.Orban, G.2021-04-20doi:10.1101/2021.04.20.440666Cold Spring Harbor Laboratory Press2021-04-20
https://biorxiv.org/cgi/content/short/2021.04.23.441023v1?rss=1"
Lituma, P. J.Woo, E.O'Hara, B. F.Castillo, P. E.Sibinga, N. E. S.Nandi, S.2021-04-23doi:10.1101/2021.04.23.441023Cold Spring Harbor Laboratory Press2021-04-23
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Herrera-Esposito, D.Gomez-Sena, L.Coen-Cagli, R.2021-04-27doi:10.1101/2021.04.26.441524Cold Spring Harbor Laboratory Press2021-04-27
https://biorxiv.org/cgi/content/short/2021.04.29.441821v1?rss=1"
Bizarro, J.Deryusheva, S.Wacheul, L.Gupta, V.Ernst, F. G.Lafontaine, D. L.Gall, J. G.Meier, U. T.2021-04-29doi:10.1101/2021.04.29.441821Cold Spring Harbor Laboratory Press2021-04-29
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Palarz, K.Neves-Carvalho, A.Duarte-Silva, S.Maciel, P.Khodakhah, K.2021-04-29doi:10.1101/2021.04.29.441865Cold Spring Harbor Laboratory Press2021-04-29
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Kobayashi, H.Singer, R. H.2021-04-30doi:10.1101/2021.04.30.442050Cold Spring Harbor Laboratory Press2021-04-30
https://biorxiv.org/cgi/content/short/2021.05.01.442200v1?rss=1"
Ramos, C. C.Lutzu, S.Yamasaki, M.Yanagawa, Y.Watanabe, M.Sakimura, K.Tomita, S.Castillo, P. E.2021-05-01doi:10.1101/2021.05.01.442200Cold Spring Harbor Laboratory Press2021-05-01
https://biorxiv.org/cgi/content/short/2021.05.02.442359v1?rss=1"
Ulloa, B. A.Habbsa, S. S.Potts, K. S.Lewis, A.McKinstry, M.Payne, S. G.Flores, J.Nizhnik, A.Feliz Norberto, M.Mosimann, C.Bowman, T. V.2021-05-03doi:10.1101/2021.05.02.442359Cold Spring Harbor Laboratory Press2021-05-03
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Folgado Marco, V.Ames, K.Gritsman, K.Baker, N. E.2021-05-04doi:10.1101/2021.05.04.442585Cold Spring Harbor Laboratory Press2021-05-04
https://biorxiv.org/cgi/content/short/2021.05.10.443464v1?rss=1"
Donegan, R. K.Copeland, J.Edgha, S.Brown, G.Hale, O. F.Mitra, A.Yang, H.Dailey, H. A.Niederweis, M.Jain, P.Reddi, A. R.2021-05-10doi:10.1101/2021.05.10.443464Cold Spring Harbor Laboratory Press2021-05-10
https://biorxiv.org/cgi/content/short/2021.05.11.443328v1?rss=1"
Oliver, D.Ramachandran, S.Philbrook, A.Lambert, C. M.Nguyen, K. C. Q.Hall, D. H.Francis, M.2021-05-11doi:10.1101/2021.05.11.443328Cold Spring Harbor Laboratory Press2021-05-11
https://biorxiv.org/cgi/content/short/2021.05.11.443637v1?rss=1"
Dickey, C. W.Verzhbinsky, I. A.Jiang, X.Rosen, B. Q.Kajfez, S.Eskandar, E. N.Gonzalez-Martinez, J.Cash, S. S.Halgren, E.2021-05-13doi:10.1101/2021.05.11.443637Cold Spring Harbor Laboratory Press2021-05-13
https://biorxiv.org/cgi/content/short/2021.05.27.445969v1?rss=1"
60 established anthropometric loci in Hispanic/Latino populations at genome-wide significance--representing up to 30% of previously-reported index SNP anthropometric associations. Trans-ethnic meta-analysis of the three ancestries showed a small-to-moderate impact of uncorrected population stratification on the resulting effect size estimates. Our novel findings demonstrate that future studies may also benefit from leveraging differences in linkage disequilibrium patterns to discover novel loci and additional signals with less residual population stratification.
]]>Fernandez-Rhodes, L.Graff, M.Buchanan, V. L.Justice, A. E.Highland, H. M.Guo, X.Young, K. L.Adhikari, K.Allred, N. P.Below, J. E.Bradfield, J.Pereira, A. C.Glover, L.Kim, D.Lilly, A. G.Shrestha, P.Thomas, A. G.Zhang, X.Chen, M.Chiang, C.Pulit, S.Horimoto, A.Krieger, J. E.Guindo-Martinez, M.Preuss, M.Schumann, C.Smit, R. A. J.Torres-Mejia, G.Acuna-Alonzo, V.Bedoya, G.Bortolini, M.-C.Canizales-Quinteros, S.Gallo, C.Gonzalez-Jose, R.Poletti, G.Rothhammer, F.Hakonarson, H.Adler, S. G.Igo, R.Iyengar, S.Nicholas, S. B.2021-05-29doi:10.1101/2021.05.27.445969Cold Spring Harbor Laboratory Press2021-05-29
https://biorxiv.org/cgi/content/short/2021.05.31.446382v1?rss=1"
Rigano, A.Ehmsen, S.Ozturk, S. U.Ryan, J.Balashov, A.Hammer, M.Kirli, K.Bellve, K.Boehm, U.Brown, C. M.Chambers, J. J.Coleman, R. A.Cosolo, A.Faklaris, O.Fogarty, K.Guilbert, T.Hamacher, A. B.Itano, M. S.Keeley, D. P.Kunis, S.Lacoste, J.Laude, A.Ma, W.Marcello, M.Montero-Llopis, P.Nelson, G.Nitschke, R.Pimentel, J. A.Weidtkamp-Peters, S.Park, P. J.Alver, B.Grunwald, D.Strambio-De-Castillia, C.2021-05-31doi:10.1101/2021.05.31.446382Cold Spring Harbor Laboratory Press2021-05-31
https://biorxiv.org/cgi/content/short/2021.06.01.446628v1?rss=1"
70 years), we found that samples from cognitively normal older individuals clustered with the "healthy aging" subgroup while AD samples mainly clustered with the "AD similar" subgroups. This may imply that individuals in the healthy aging subgroup will likely remain cognitively normal when they become older and vice versa. In summary, our results suggest that on the transcriptome level, aging and LOAD have strong interconnections in some brain regions in a subpopulation of cognitively normal aging individuals. This supports the theory that the initiation of LOAD occurs decades earlier than the manifestation of clinical phenotype and it may be essential to closely study the "normal brain aging" to identify the very early molecular events that may lead to LOAD development.
]]>Peng, S.Zeng, L.Haure-mirande, J.-v.Wang, M.Huffman, D. M.Haroutunian, V.Ehrlich, M.Zhang, B.Tu, Z.2021-06-02doi:10.1101/2021.06.01.446628Cold Spring Harbor Laboratory Press2021-06-02
https://biorxiv.org/cgi/content/short/2021.06.02.446746v1?rss=1"
Kunota, T. T. R.Rahman, M. A.Truebody, B. E.Mackenzie, J. S.Saini, V.Lamprecht, D. A.Adamson, J. H.Sevalkar, R. R.Lancaster, J. R.Berney, M.Glasgow, J. N.Steyn, A. J.2021-06-02doi:10.1101/2021.06.02.446746Cold Spring Harbor Laboratory Press2021-06-02
https://biorxiv.org/cgi/content/short/2021.06.06.447265v1?rss=1"
DiNatale, R. G.Mano, R.Makarov, V.Rusk, N.Drill, E.Winer, A.Sankin, A.Yoo, A.Freeman, B. A.Hsieh, J. J.Chen, Y.-B.Coleman, J. A.Berger, M. G.Ostrovnaya, I.Chan, T. A.Russo, P.Reznik, E.Hakimi, A. A.2021-06-07doi:10.1101/2021.06.06.447265Cold Spring Harbor Laboratory Press2021-06-07
https://biorxiv.org/cgi/content/short/2021.06.07.447454v1?rss=1"
Monday, H. R.Kharod, S. C.Yoon, Y. J.Singer, R. H.Castillo, P. E.2021-06-08doi:10.1101/2021.06.07.447454Cold Spring Harbor Laboratory Press2021-06-08
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Haslwanter, D.Dieterle, M. E.Wec, A. Z.O'Brien, C. M.Sakharkar, M.Florez, C.Tong, K.Rappazzo, C. G.Lasso, G.Vergnolle, O.Wirchnianski, A. S.Bortz, R. H.Laudermilch, E.Fels, J. M.Mengotto, A.Malonis, R. J.Georgiev, G. I.Quiroz, J.Wrapp, D.Wang, N.Dye, K. E.Barnhill, J.Dye, J. M.McLellan, J. S.Daily, J. P.Lai, J. R.Herbert, A. S.Walker, L.Chandran, K.Jangra, R. K.2021-06-11doi:10.1101/2021.06.10.447999Cold Spring Harbor Laboratory Press2021-06-11
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Liu, W.Chou, T.-F.Garrett-Thomson, S. C.Seo, G.-Y.Fedorov, E.Ramagopa, U. A.Bonanno, J. B.Kakugawa, K.Cheroutre, H.Kronenberg, M.Almo, S. C.2021-06-16doi:10.1101/2021.06.16.448617Cold Spring Harbor Laboratory Press2021-06-16
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Kim, Y.Lasso, G.Patel, H.Vardarajan, B.Santa-Maria, I.Lefort, R.2021-06-18doi:10.1101/2021.06.17.448790Cold Spring Harbor Laboratory Press2021-06-18
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Kauffman, K. M.Chang, W. K.Brown, J. M.Hussain, F. A.Yang, J. Y.Polz, M. F.Kelly, L.2021-06-27doi:10.1101/2021.06.27.449121Cold Spring Harbor Laboratory Press2021-06-27
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Miller, A.Lin, B.Pincus, M. R.Fine, E. J.Feinman, R. D.2021-06-28doi:10.1101/2021.06.27.450024Cold Spring Harbor Laboratory Press2021-06-28
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Nasrallah, K.Frechou, M. A.Yoon, Y. J.Persaud, S.Goncalves, T.Castillo, P. E.2021-06-30doi:10.1101/2021.06.30.450628Cold Spring Harbor Laboratory Press2021-06-30
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Lofgren, K. A.Sreekumar, S.Jenkins, E. C.Ernzen, K. J.Kenny, P. A.2021-07-08doi:10.1101/2021.07.07.451518Cold Spring Harbor Laboratory Press2021-07-08
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Kiparaki, M.Khan, C.Folgado Marco, V.Chuen, J.Baker, N. E.2021-07-12doi:10.1101/2021.07.12.452023Cold Spring Harbor Laboratory Press2021-07-12
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Guo, N.McDermott, K.Shih, Y.-T.Zanga, H.Ghosh, D.Goncalves, T.Sahay, A.2021-07-14doi:10.1101/2021.07.14.452351Cold Spring Harbor Laboratory Press2021-07-14
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von Grüning, H.Coradin, M.Mendoza, M.Reader, J.Sidoli, S.Garcia, B.Birkholtz, L.-M.2021-07-20doi:10.1101/2021.07.19.452879Cold Spring Harbor Laboratory Press2021-07-20
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Rivera-Cuevas, Y.Mayoral, J.Di Cristina, M.Lawrence, A.-L. E.Olafsson, E. B.Thornhill, D.Waldman, B. S.Ono, A.Sexton, J.Lourido, S.Weiss, L. M.Carruthers, V. B.2021-07-21doi:10.1101/2021.07.21.453261Cold Spring Harbor Laboratory Press2021-07-21
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Furtado, R.Delahaye, F.Zhang, J.Sung, J.Karell, P.Kim, R. S.Caillat-Zucman, S.Liang, L.Felgner, P.Bauleni, A.Gama, S.Buchwald, A.Taylor, T.Seydel, K.Laufer, M.Daily, J.Lauvau, G.2021-07-23doi:10.1101/2021.07.21.453277Cold Spring Harbor Laboratory Press2021-07-23
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Islam, K.Wagner, S.Ghosh, A.Sudhamalla, B.Jnawali, H. N.Debiec, R.Fedorov, E.2021-07-28doi:10.1101/2021.07.28.453719Cold Spring Harbor Laboratory Press2021-07-28
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Haas, B.Dobin, A.Ghandi, M.Van Arsdale, A.Tickle, T. L.Robinson, J. T.Gilliani, R.Kasif, S.Regev, A.2021-08-04doi:10.1101/2021.08.02.454639Cold Spring Harbor Laboratory Press2021-08-04
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Babb, R.Doyle, C. R.Pirofski, L.-a.2021-08-03doi:10.1101/2021.08.02.454853Cold Spring Harbor Laboratory Press2021-08-03
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Kao, Y.-R.Chen, J.Kumari, R.Tatiparthy, M.Ma, Y.Aivalioti, M.Zintiridou, A.Thiruthuvanathan, V.Reisz, J.Stransky, S.Sidoli, S.Steidl, U.D'Alessandro, A.Will, B.2021-08-05doi:10.1101/2021.08.03.454947Cold Spring Harbor Laboratory Press2021-08-05
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Nguyen, T. N. B.Ely, B. A.Kim-Schulze, S.Gabbay, V.2021-08-09doi:10.1101/2021.08.07.455522Cold Spring Harbor Laboratory Press2021-08-09
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Coradin, M.Cesare, J.Lan, Y.Zhu, Z.Lund, P. J.Sidoli, S.Kori, Y.Lu, C.Porter, E. G.Robert, C. W. M.Garcia, B. A.2021-08-10doi:10.1101/2021.08.10.455684Cold Spring Harbor Laboratory Press2021-08-10
https://biorxiv.org/cgi/content/short/2021.08.17.456680v1?rss=1"
Opalko, H. E.Miller, K. E.Kim, H.-S.Vargas-Garcia, C. A.Singh, A.Keogh, M.-C.Moseley, J. B.2021-08-17doi:10.1101/2021.08.17.456680Cold Spring Harbor Laboratory Press2021-08-17
https://biorxiv.org/cgi/content/short/2021.08.19.457035v1?rss=1"
Pan, X.Coen-Cagli, R.Schwartz, O.2021-08-19doi:10.1101/2021.08.19.457035Cold Spring Harbor Laboratory Press2021-08-19
https://biorxiv.org/cgi/content/short/2021.08.20.457069v1?rss=1"
Maron, M. I.Casill, A. D.Gupta, V.Sidoli, S.Query, C. C.Gamble, M. J.Shechter, D.2021-08-20doi:10.1101/2021.08.20.457069Cold Spring Harbor Laboratory Press2021-08-20
https://biorxiv.org/cgi/content/short/2021.08.22.457235v1?rss=1"
Haslwanter, D.Lasso, G.Wec, A. Z.Furtado, N. D.Raphael, L. M. S.Sun, Y.Stransky, S.Pedreno-Lopez, N.Tse, A.Correia, C. A.Bornholdt, Z. A.Sakharkar, M.Avelino-Silva, V. I.Moyer, C. L.Watkins, D. I.Kallas, E. G.Sidoli, S.Walker, L. M.Bonaldo, M. C.Chandran, K.2021-08-22doi:10.1101/2021.08.22.457235Cold Spring Harbor Laboratory Press2021-08-22
https://biorxiv.org/cgi/content/short/2021.08.24.457582v1?rss=1"
Lee, S.Wong, H.Castiglione, M.Murphy, M.Kaushansky, K.Zhan, H.2021-08-27doi:10.1101/2021.08.24.457582Cold Spring Harbor Laboratory Press2021-08-27
https://biorxiv.org/cgi/content/short/2021.08.24.457589v1?rss=1"
Zhang, H.Castiglione, M.Zheng, L.Zhan, H.2021-08-26doi:10.1101/2021.08.24.457589Cold Spring Harbor Laboratory Press2021-08-26
https://biorxiv.org/cgi/content/short/2021.08.30.458230v1?rss=1"
Gokcen, E.Jasper, A. I.Semedo, J. D.Zandvakili, A.Kohn, A.Machens, C. K.Yu, B. M.2021-09-01doi:10.1101/2021.08.30.458230Cold Spring Harbor Laboratory Press2021-09-01
https://biorxiv.org/cgi/content/short/2021.08.31.458429v1?rss=1"
Kori, Y.Lund, P. J.Trovato, M.Sidoli, S.Yuan, Z.-F.Noh, K.-M.Garcia, B. A.2021-09-02doi:10.1101/2021.08.31.458429Cold Spring Harbor Laboratory Press2021-09-02
https://biorxiv.org/cgi/content/short/2021.09.03.458092v1?rss=1"
Jordan, J. T.Goncalves, J. T.2021-09-05doi:10.1101/2021.09.03.458092Cold Spring Harbor Laboratory Press2021-09-05
https://biorxiv.org/cgi/content/short/2021.09.03.458915v1?rss=1"
Augustine, T.John, P.Friedman, T.Jiffry, J.Guzik, H.Mannan, R.Gupta, R.Delano, C.Mariadason, J.Zang, X.Maitra, R.Goel, S.2021-09-04doi:10.1101/2021.09.03.458915Cold Spring Harbor Laboratory Press2021-09-04
https://biorxiv.org/cgi/content/short/2021.09.14.460352v1?rss=1"
Speranza, L.Inglebert, Y.De Sanctis, C.Wu, P. Y.Kalinowska, M.McKinney, R. A.Francesconi, A.2021-09-17doi:10.1101/2021.09.14.460352Cold Spring Harbor Laboratory Press2021-09-17
https://biorxiv.org/cgi/content/short/2021.09.22.461415v1?rss=1"
Velimirovic, M.Zanetti, L.Shen, M. W.Fife, J. D.Lin, L.Cha, M.Akinci, E.Barnum, D.Yu, T.Sherwood, R. I.2021-09-23doi:10.1101/2021.09.22.461415Cold Spring Harbor Laboratory Press2021-09-23
https://biorxiv.org/cgi/content/short/2021.09.27.462002v1?rss=1"
Ortega Gonzalez, P.Taylor, G. M.Jangra, R.Tenorio Vela, R.Fernandez de Castro Martin, I.Mainou, B.Orchard, R.Wilen, C. B.Brigleb, P. A.Sojati, J.Chandran, K.Risco, C.Dermody, T. S.2021-09-28doi:10.1101/2021.09.27.462002Cold Spring Harbor Laboratory Press2021-09-28
https://biorxiv.org/cgi/content/short/2021.09.28.462124v1?rss=1"
Tang, Y.Zong, H.Kwon, H.Qiu, Y.Pessin, J. B.Wu, L.Buddo, K. A.Boykov, I.Schmidt, C.Lin, C.-T.Neufer, P. D.Schwartz, G. J.Kurland, I. J.Pessin, J. E.2021-09-30doi:10.1101/2021.09.28.462124Cold Spring Harbor Laboratory Press2021-09-30
https://biorxiv.org/cgi/content/short/2021.09.30.462547v1?rss=1"
Cibelli, A.Stout, R.Timmermann, A.de Menezes, L.Guo, P.Maass, K.Seifert, G.Steinhaeuser, C.Spray, D. C.Scemes, E.2021-10-01doi:10.1101/2021.09.30.462547Cold Spring Harbor Laboratory Press2021-10-01
https://biorxiv.org/cgi/content/short/2021.10.01.462432v1?rss=1"
Veling, M. T.Nguyen, D. T.Thadani, N. N.Oster, M. E.Rollins, N. J.Brock, K. P.Bethel, N. P.Baker, D.Way, J. C.Marks, D. S.Chang, R. L.Silver, P. A.2021-10-01doi:10.1101/2021.10.01.462432Cold Spring Harbor Laboratory Press2021-10-01
https://biorxiv.org/cgi/content/short/2021.10.01.462786v1?rss=1"
Guetta-Terrier, C.Karambizi, D.Akosman, B.Chen, J.-S.Kamle, S.Fajardo, J. E.Fiser, A.Singh, R.Toms, S. A.Lee, C. G.Elias, J. A.Tapinos, N.2021-10-01doi:10.1101/2021.10.01.462786Cold Spring Harbor Laboratory Press2021-10-01
https://biorxiv.org/cgi/content/short/2021.10.02.462895v1?rss=1"
Andreyeva, E. N.Emelyanov, A. V.Nevil, M.Sun, L.Vershilova, E.Hill, C. A.Keogh, M. C.Duronio, R. J.Skoultchi, A. I.Fyodorov, D. V.2021-10-03doi:10.1101/2021.10.02.462895Cold Spring Harbor Laboratory Press2021-10-03
https://biorxiv.org/cgi/content/short/2021.10.03.462893v1?rss=1"
Feliz Norberto, M.Michael, C.de Oliveira, S.2021-10-04doi:10.1101/2021.10.03.462893Cold Spring Harbor Laboratory Press2021-10-04
https://biorxiv.org/cgi/content/short/2021.10.03.462944v1?rss=1"
Zhang, S.Wang, J.Liu, Q.McDonald, W. H.Bomber, M.Layden, H.Ellis, J.Borinstein, S.Hiebert, S. W.Stengel, K. R.2021-10-04doi:10.1101/2021.10.03.462944Cold Spring Harbor Laboratory Press2021-10-04
https://biorxiv.org/cgi/content/short/2021.10.05.463200v1?rss=1"
Wang, S.Lee, K.Gray, S.Zhang, Y.Tangcatherin, C.Morrish, R.Tosti, E.van Oers, J.Cohen, P.MacCarthy, T.Roa, S.Scharff, M. D.Edelmann, W.Chahwan, R.2021-10-05doi:10.1101/2021.10.05.463200Cold Spring Harbor Laboratory Press2021-10-05
https://biorxiv.org/cgi/content/short/2021.10.07.463512v1?rss=1"
Nasrallah, K.Berthoux, C.Hashimotodani, Y.Chavez, A. E.Gulfo, M.Lujan, R.Castillo, P. E.2021-10-09doi:10.1101/2021.10.07.463512Cold Spring Harbor Laboratory Press2021-10-09
https://biorxiv.org/cgi/content/short/2021.10.07.463524v1?rss=1"
15 mm), white matter stimulation consistently produced larger responses than stimulation in or near grey matter. These relationships were different between cingulate, lateral prefrontal, and lateral temporal cortical stimulation.
ConclusionThese results demonstrate the importance of location and stimulation parameters in inducing a specific output and indicate that a stronger local response may require stimulation in the grey-white boundary while stimulation in the white matter may be needed for network activation, suggesting that stimulation location can be tailored for a specific outcome, key to informed neuromodulatory therapy.
HighlightsO_LIIntracranial single pulse electrical stimulation (SPES) response increases with increased pulse duration mostly near the stimulation site
C_LIO_LISPES response varies nonlinearly with injected current with an effect of distance from the stimulation site.
C_LIO_LISPES near the grey-white boundary and 90{degrees} to the nearest cortical axis induces larger local responses, but white matter stimulation produces larger distant responses.
C_LIO_LIThe relationship between SPES location and responses depends on brain region stimulated
C_LI
]]>Paulk, A. C.Zelmann, R.Crocker, B.Widge, A. S.Dougherty, D. D.Eskandar, E. N.Weisholtz, D. S.Richardson, M.Cosgrove, R.Cash, S. S.2021-10-09doi:10.1101/2021.10.07.463524Cold Spring Harbor Laboratory Press2021-10-09
66,000 individuals
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https://biorxiv.org/cgi/content/short/2021.10.11.463514v1?rss=1"
Selvaraj, M. S.Li, X.Li, Z.Pampana, A.Zhang, D. Y.Park, J.Aslibekyan, S.Bis, J. C.Brody, J. A.Cade, B. E.Chuang, L.-M.Chung, R.-H.Curran, J. E.de las Fuentes, L.de Vries, P. S.Duggirala, R.Freedman, B. I.Graff, M.Guo, X.Heard-Costa, N.Hidalgo, B.Hwu, C.-M.Irvin, M. R.Kelly, T. N.Kral, B. G.Lange, L.Li, X.Lisa, M.Lubitz, S. A.Manichaikul, A. W.Michael, P.Montasser, M. E.Morrison, A. C.Naseri, T.O'Connell, J. R.Palmer, N. D.Peyser, P. A.Reupena, M. S.Smith, J. A.Sun, X.Taylor, K. D.Tracy, R. P.Tsai, M. Y.Wang,2021-10-12doi:10.1101/2021.10.11.46351466,000 individuals]]>Cold Spring Harbor Laboratory Press2021-10-12
https://biorxiv.org/cgi/content/short/2021.10.11.464022v1?rss=1"
Bülow, H. E.Rahman, M.Ramirez-Suarez, N. J.Diaz-Balzac, C. A.2021-10-13doi:10.1101/2021.10.11.464022Cold Spring Harbor Laboratory Press2021-10-13
https://biorxiv.org/cgi/content/short/2021.10.15.464577v1?rss=1"
Astorkia, M.Lachman, H.Zheng, D.2021-10-15doi:10.1101/2021.10.15.464577Cold Spring Harbor Laboratory Press2021-10-15
https://biorxiv.org/cgi/content/short/2021.10.15.464608v1?rss=1"
Liu, H.Ling, W.Hua, X.Moon, J.-Y.Williams-Nguyen, J. S.Zhan, X.Plantinga, A. M.Zhao, N.Zhang, A.Knight, R.Qi, Q.Burk, R. D.Kaplan, R. C.Wu, M. C.2021-10-16doi:10.1101/2021.10.15.464608Cold Spring Harbor Laboratory Press2021-10-16
https://biorxiv.org/cgi/content/short/2021.10.19.464978v1?rss=1"
Chin, S. S.Guillen, E.Chorro, L.Achar, S.Oberle, S.Ng, K.Alfei, F.Zehn, D.Altan-Bonnet, G.DELAHAYE, F.Lauvau, G.2021-10-20doi:10.1101/2021.10.19.464978Cold Spring Harbor Laboratory Press2021-10-20
https://biorxiv.org/cgi/content/short/2021.10.21.465350v1?rss=1"
Henry, C. A.Kohn, A.2021-10-23doi:10.1101/2021.10.21.465350Cold Spring Harbor Laboratory Press2021-10-23
https://biorxiv.org/cgi/content/short/2021.10.22.465419v1?rss=1"
Pelletier, A.Carrier, A.Zhao, Y.Canouil, M.Derhourhi, M.Durand, E.Berberian-Ferrato, L.Greally, J.Hughes, F.Froguel, P.Bonnefond, A.Delahaye, F.2021-10-24doi:10.1101/2021.10.22.465419Cold Spring Harbor Laboratory Press2021-10-24
https://biorxiv.org/cgi/content/short/2021.10.26.465924v1?rss=1"
180 days post-stroke) compiled from 18 research cohorts worldwide in the ENIGMA Stroke Recovery Working Group (age: median = 61 years, interquartile range = 18, range = 23-93; 135 women and 222 men). Sensorimotor impairment was estimated from the Fugl-Meyer Assessment of Upper Extremity scores. Robust mixed-effects linear models were used to test associations between post-stroke sensorimotor impairment and hippocampal volumes (ipsilesional and contralesional separately; Bonferroni-corrected, p-value < 0.025), controlling for age, sex, lesion volume, and lesioned hemisphere. We also performed an exploratory analysis to test whether sex differences influence the relationship between sensorimotor impairment and hippocampal volume.
Upper limb sensorimotor impairment was positively associated with ipsilesional (p = 0.005; d = 0.33) but not contralesional (p = 0.96; d = 0.01) hippocampal volume, such that impairment was worse for participants with smaller ipsilesional hippocampal volume. This association remained significant independent of lesion volume or other covariates (p = 0.001; d = 0.36). Evidence indicates an interaction between sensorimotor impairment and sex for both ipsilesional (p = 0.008; d = -0.29) and contralesional (p = 0.006; d = -0.30) hippocampal volumes, whereby women showed progressively worsening sensorimotor impairment with smaller hippocampal volumes compared to men.
The present study has identified a novel association between chronic post-stroke sensorimotor impairment and ipsilesional, but not contralesional, hippocampal volume. This finding was not due to lesion size and may be stronger in women. We also provide supporting evidence that smaller hippocampal volume post-stroke is likely a consequence of ipsilesional damage, which could provide a link between vascular disease and other disorders, such as dementia.
]]>Zavaliangos-Petropulu, A.Lo, B.Donnelly, M. R.Schweighofer, N.Lohse, K.Jahanshad, N.Barisano, G.Banaj, N.Borich, M. R.Boyd, L. A.Buetefisch, C. M.Byblow, W. D.Cassidy, J. M.Charalambous, C. C.Conforto, A. B.DiCarlo, J. A.Dula, A. N.Egorova-Brumley, N.Etherton, M. R.Feng, W.Fercho, K. A.Geranmayeh, F.Hanlon, C. A.Hayward, K. S.Hordacre, B.Kautz, S. A.Khlif, M. S.Kim, H.Kuceyeski, A.Lin, D. J.Lotze, M.Liu, J.MacIntosh, B. J.Margetis, J. L.Piras, F.Ramos-Murguialday, A.Revill, K. P.Roberts, P. S.Robertson, A. D.Schambra2021-10-28doi:10.1101/2021.10.26.465924Cold Spring Harbor Laboratory Press2021-10-28
https://biorxiv.org/cgi/content/short/2021.10.29.466479v1?rss=1"
Das, S.Lituma, P. J.Castillo, P. E.Singer, R. H.2021-11-01doi:10.1101/2021.10.29.466479Cold Spring Harbor Laboratory Press2021-11-01
https://biorxiv.org/cgi/content/short/2021.10.31.466715v1?rss=1"
Senecal, A.Singer, R. H.Coleman, R. A.2021-11-02doi:10.1101/2021.10.31.466715Cold Spring Harbor Laboratory Press2021-11-02
https://biorxiv.org/cgi/content/short/2021.11.02.467042v1?rss=1"
Mayoral, J.Guevara, R. B.Rivera-Cuevas, Y.Tu, V.Tomita, T.Romano, J. D.Gunther-Cummins, L.Sidoli, S.Coppens, I.Carruthers, V. B.Weiss, L. M.2021-11-03doi:10.1101/2021.11.02.467042Cold Spring Harbor Laboratory Press2021-11-03
https://biorxiv.org/cgi/content/short/2021.11.09.467887v1?rss=1"
Busschers, E.Ahmad, N.Sun, L.Iben, J. R.Walkey, C. J.Rusin, A.Yuen, T.J. Rosen, C.Willis, I. M.Zaidi, M.Johnson, D. L.2021-11-11doi:10.1101/2021.11.09.467887Cold Spring Harbor Laboratory Press2021-11-11
https://biorxiv.org/cgi/content/short/2021.11.12.468452v1?rss=1"
Hiramoto, T.Boku, S.Kang, G.Abe, S.Barbachan e Silva, M.Tanigaki, K.Nagashima, M.Ye, K.Yamauchi, T.Michurina, T. V.O Broin, P.Enikolopov, G.Hiroi, N.2021-11-13doi:10.1101/2021.11.12.468452Cold Spring Harbor Laboratory Press2021-11-13
https://biorxiv.org/cgi/content/short/2021.11.15.468657v1?rss=1"
250 ms) that appears to be involved in both object recognition and possibly memory consolidation. Results from this study provide support for multiple stages of multisensory object learning and recognition that are subserved by an extended network of cortical areas.
]]>Vercillo, T.Freedman, E. G.Ewen, J. B.Molholm, S.Foxe, J. J.2021-11-15doi:10.1101/2021.11.15.468657Cold Spring Harbor Laboratory Press2021-11-15
https://biorxiv.org/cgi/content/short/2021.11.17.468943v1?rss=1"
Srinivasan, V.Brognaro, H.Prabhu, P. R.de Souza, E. E.Guenther, S.Reinke, P. Y. A.J. Lane, T.Ginn, H.Han, H.Ewert, W.Sprenger, J.Koua, F. H. M.Falke, S.Werner, N.Andaleeb, H.Ullah, N.Alves Franca, B.Wang, M.Luana C Barra, A.Perbandt, M.Schwinzer, M.Schmidt, C.Brings, L.Lorenzen, K.Schubert, R.Rahal Guaragna Machado, R.Donizette Candido, E.Bruna Leal Oliveira, D.Luiz Durigon, E.Yefanov, O.Lieske, J.Gelisio, L.Domaracky, M.Middendorf, P.Groessler, M.Trost, F.Galchenkova, M.Saouane, S.Hakanpaeae, J.Wolf, M.Turk, D.P2021-11-22doi:10.1101/2021.11.17.468943Cold Spring Harbor Laboratory Press2021-11-22
https://biorxiv.org/cgi/content/short/2021.11.20.469295v1?rss=1"
Garre, J. M.Bukauskas, F. F.Bennett, M. V.2021-11-22doi:10.1101/2021.11.20.469295Cold Spring Harbor Laboratory Press2021-11-22
https://biorxiv.org/cgi/content/short/2021.11.26.470028v1?rss=1"
Aggad, D.Omi, S.Essmann, C. L.Brouilly, N.Richard, F.Cazevieille, C.Politi, K. A.Hall, D. D.Ewbank, J.Pujol, R.Pujol, N.2021-11-26doi:10.1101/2021.11.26.470028Cold Spring Harbor Laboratory Press2021-11-26
https://biorxiv.org/cgi/content/short/2021.11.28.470233v1?rss=1"
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org.highwire.dtl.DTLVardef@13a7176org.highwire.dtl.DTLVardef@1ef1c75org.highwire.dtl.DTLVardef@1355eeforg.highwire.dtl.DTLVardef@ebc275_HPS_FORMAT_FIGEXP M_FIG C_FIG
]]>Dasgupta, S.Dyagi, D. Y.Haimovich, G.Wyler, E.Olender, T.Singer, R. H.Landthaler, M.Gerst, J. E.2021-11-28doi:10.1101/2021.11.28.470233Cold Spring Harbor Laboratory Press2021-11-28
https://biorxiv.org/cgi/content/short/2021.11.29.470444v1?rss=1"
Dragotakes, Q.Jacobs, E.Ramirez, L. S.Yoon, O. I.Perez-Stable, C.Eden, H.Pagnotta, J.Vij, R.Bergman, A.D'Alessio, F.Casadevall, A.2021-11-29doi:10.1101/2021.11.29.470444Cold Spring Harbor Laboratory Press2021-11-29
https://biorxiv.org/cgi/content/short/2021.12.07.471603v1?rss=1"
Lubiana, T.Nakaya, H.2021-12-09doi:10.1101/2021.12.07.471603Cold Spring Harbor Laboratory Press2021-12-09
https://biorxiv.org/cgi/content/short/2021.12.07.471619v1?rss=1"
Sun, D.Filipescu, D.Hasson, D.Singh, D. K.Carcamo, S.Khalil, B.Miles, B.Westra, W.Sproll, K. C.Bernstein, E.Aguirre-Ghiso, J. A.2021-12-07doi:10.1101/2021.12.07.471619Cold Spring Harbor Laboratory Press2021-12-07
https://biorxiv.org/cgi/content/short/2021.12.07.471632v1?rss=1"
Naranjo, S.Cabana, C. M.LaFave, L. M.Westcott, P. M.Romero, R.Ghosh, A.Liao, L. Z.Schenkel, J. M.Del Priore, I.Bhutkar, A.Yang, D.Jacks, T.2021-12-07doi:10.1101/2021.12.07.471632Cold Spring Harbor Laboratory Press2021-12-07
https://biorxiv.org/cgi/content/short/2021.12.08.471650v1?rss=1"
Kazmierczak, M.Nicola, S. M.2021-12-09doi:10.1101/2021.12.08.471650Cold Spring Harbor Laboratory Press2021-12-09
https://biorxiv.org/cgi/content/short/2021.12.09.471942v1?rss=1"
Voit, R. A.Tao, L.Yu, F.Cato, L. D.Cohen, B.Liao, X.Fiorini, C.Nandakumar, S. K.Wahlster, L.Teichert, K.Regev, A.Sankaran, V. G.2021-12-09doi:10.1101/2021.12.09.471942Cold Spring Harbor Laboratory Press2021-12-09
https://biorxiv.org/cgi/content/short/2021.12.10.471810v1?rss=1"
Weinstock, J. S.Gopakumar, J.Burugula, B. B.Uddin, M. M.Jahn, N.Belk, J. A.Daniel, B.Ly, N.Mack, T. M.Laurie, C. A.Broome, J. G.Taylor, K. D.Guo, X.Sinner, M. F.von Falkenhausen, A. S.Kaab, S.Shuldiner, A. R.O'Connell, J. R.Lewis, J. P.Boerwinkle, E.Barnes, K. C.Chami, N.Kenny, E. E.Loos, R. J. F.Fornage, M.Hou, L.Lloyd-Jones, D. M.Redline, S.Cade, B. E.Psaty, B. M.Bis, J. C.Brody, J. A.Silverman, E. K.Yun, J. H.Qiao, D.Palmer, N. D.Freedman, B. I.Bowden, D. W.Cho, M. H.DeMeo, D. L.Vasan, R. S.Johnson, A. D.Mat2021-12-13doi:10.1101/2021.12.10.471810Cold Spring Harbor Laboratory Press2021-12-13
https://biorxiv.org/cgi/content/short/2021.12.10.472114v1?rss=1"
Coluzzi, C.Garcillan-Barcia, M. d. P.de la Cruz, F.Rocha, E. P. C.2021-12-11doi:10.1101/2021.12.10.472114Cold Spring Harbor Laboratory Press2021-12-11
https://biorxiv.org/cgi/content/short/2021.12.13.472381v1?rss=1"
Gorbunova, V.Simon, M.Trombline, G.Yang, J.Earley, E. J.Zhang, L.Gigas, J.Zagorulya, M.Gilbert, M.Robbins, P. D.Vijg, J.Seluanov, A.Suh, Y.Garcia, B.Thomas, D. D.Yuen, S. L.Pope, A.Van Meter, M.Emmrich, S.Moody, K.Barzilai, N.Wolfe, A.Atzmon, G.Schaff, T. M.2021-12-13doi:10.1101/2021.12.13.472381Cold Spring Harbor Laboratory Press2021-12-13
https://biorxiv.org/cgi/content/short/2021.12.16.472826v1?rss=1"
De Sanctis, P.Wagner, J.Molholm, S.Foxe, J. J.Blumen, H.Horsthuis, D.2021-12-17doi:10.1101/2021.12.16.472826Cold Spring Harbor Laboratory Press2021-12-17
https://biorxiv.org/cgi/content/short/2021.12.16.472958v1?rss=1"
Lituma, P. J.Singer, R. H.Das, S.Castillo, P. E.2021-12-17doi:10.1101/2021.12.16.472958Cold Spring Harbor Laboratory Press2021-12-17
https://biorxiv.org/cgi/content/short/2021.12.28.474388v1?rss=1"
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Rajshekar, S.Yao, J.Arnold, P. K.Payne, S. G.Zhang, Y.Bowman, T. V.Schmitz, R. J.Edwards, J. R.Goll, M. G.2018-08-23doi:10.1101/396671Cold Spring Harbor Laboratory Press2018-08-23
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Demaerel, W.Mostovoy, Y.Yilmaz, F.Vervoort, L.Pastor, S.Hestand, M. S.Swillen, A.Vergaelen, E.Geiger, E. A.Coughlin, C. R.Chow, S. K.McDonald-McGinn, D.Morrow, B.Kwok, P.-Y.Xiao, M.Emanuel, B. S.Shaikh, T. H.Vermeesch, J. R.2018-09-12doi:10.1101/403873Cold Spring Harbor Laboratory Press2018-09-12
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Mukherjee, J.Hermesh, O.Nalpas, N.Franz-Wachtel, M.Macek, B.Jansen, R.-P.2018-08-31doi:10.1101/405589Cold Spring Harbor Laboratory Press2018-08-31
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Shieh, K. R.Kratschmer, C.Maier, K. E.Greally, J. M.Levy, M.Golden, A.2018-09-12doi:10.1101/413757Cold Spring Harbor Laboratory Press2018-09-12
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Chen, X.Li, Y.Wang, C.Tang, Y.Mok, S.-A.Tsai, R. M.Rojas, J. C.Karydas, A.Miller, B. L.Boxer, A. L.Gestwicki, J. E.Cuervo, A. M.Arkin, M.Gan, L.2018-09-14doi:10.1101/418640Cold Spring Harbor Laboratory Press2018-09-14
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Antonioli, E.Torres, N.Ferretti, M.Piccinato, C. d. A.Sertie, A. L.2018-09-17doi:10.1101/420026Cold Spring Harbor Laboratory Press2018-09-17
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Leonard, H.Blauwendraat, C.Krohn, L.Faghri, F.Iwaki, H.Furgeson, G.Day-Williams, A. G.Stone, D. J.International Parkinson's Disease Genomics Consortium (IPDGC),Singleton, A. B.Nalls, M. A.Gan-Or, Z.2018-10-05doi:10.1101/427385Cold Spring Harbor Laboratory Press2018-10-05
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Mutlu, B.Chen, H.-M. M.Hall, D. H.Mango, S. E.2018-09-28doi:10.1101/429902Cold Spring Harbor Laboratory Press2018-09-28
https://biorxiv.org/cgi/content/short/431213v1?rss=1"
Wang, N.Zheng, J.Chen, Z.Liu, Y.Dura, B.Kwak, M.Xavier-Ferrucio, J.Lu, Y.-C.Zhang, M.Roden, C.Cheng, J.Krauss, D.Ding, Y.Fan, R.Lu, J.2018-09-30doi:10.1101/431213Cold Spring Harbor Laboratory Press2018-09-30
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Delahaye, F.Do, C.Kong, Y.Ashkar, R.Salas, M.Tycko, B.Wapner, R.Hughes, F.2018-10-03doi:10.1101/432211Cold Spring Harbor Laboratory Press2018-10-03
https://biorxiv.org/cgi/content/short/433755v1?rss=1"
Sawyers, C. L.Lee, E.Wongvipat, J.Choi, D.Wang, P.Zheng, D.Watson, P. A.Gopalan, A.2018-10-02doi:10.1101/433755Cold Spring Harbor Laboratory Press2018-10-02
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Pagano, M.Jeong, Y.-T.Simoneschi, D.Keegan, S.Melville, D.Adler, N.Saraf, A.Florens, L.Washburn, M. P.Cavasotto, C.Fenyö, D.Cuervo, A. M.Rossi, M.2018-10-12doi:10.1101/441923Cold Spring Harbor Laboratory Press2018-10-12
https://biorxiv.org/cgi/content/short/441980v1?rss=1"
Stutz, F.Infantino, V.Tutucci, E.Yeh Martin, N.Zihlmann, A.Garcia-Molinero, V.Silvano, G.Palancade, B.2018-10-12doi:10.1101/441980Cold Spring Harbor Laboratory Press2018-10-12
https://biorxiv.org/cgi/content/short/459735v1?rss=1"
Pique, D. G.Andriani, G. A.Maggi, E.Zimmerman, S. E.Greally, J. M.Montagna, C.Mar, J. C.2018-11-01doi:10.1101/459735Cold Spring Harbor Laboratory Press2018-11-01
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Tajara, E. H.Villagra, U. M.da Cunha, B. R.Polachini, G. M.Henrique, T.da Silva, C. H. T. P.Feitosa, O. A.Erica E. Fukuyama, E. E.Lopez, R. V. M.Dias-Neto, E.Nunes, F. D.Severino, P.2018-11-08doi:10.1101/466011Cold Spring Harbor Laboratory Press2018-11-08
https://biorxiv.org/cgi/content/short/470286v1?rss=1"
Beghini, F.Renson, A.Zolnik, C.Geistlinger, L.Usyk, M.Moody, T. U.Thorpe, L.Dowd, J. B.Burk, R.Segata, N.Jones, H. E.Waldron, L. D.2018-11-14doi:10.1101/470286Cold Spring Harbor Laboratory Press2018-11-14
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Dragotakes, Q.Stouffer, K.Fu, M. S.Leon-Rodriguez, C. M.Freij, J. B.Bergman, A.Casadevall, A.2018-11-15doi:10.1101/470617Cold Spring Harbor Laboratory Press2018-11-15
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Butler, V. J.Cortopassi, W. A.Argouarch, A. R.Pierce, O. M.Vohra, M.Oses-Prieto, J. A.Gao, F.Caballero, B.Chand, S.Seeley, W. W.Miller, B. L.Coppola, G.Burlingame, A. L.Ashrafi, K.Cuervo, A. M.Jacobson, M.Kao, A. W.2018-11-17doi:10.1101/472258Cold Spring Harbor Laboratory Press2018-11-17
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Ratliff, J.Marder, E.O'Leary, T.2018-11-29doi:10.1101/480830Cold Spring Harbor Laboratory Press2018-11-29
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Liu, Y.Wang, T.Zheng, D.2018-11-29doi:10.1101/483297Cold Spring Harbor Laboratory Press2018-11-29
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Brittin, C. A.Cook, S. J.Hall, D. H.Emmons, S. W.Cohen, N.2018-12-04doi:10.1101/485771Cold Spring Harbor Laboratory Press2018-12-04
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Hernandez, I.Luna, G.Rauch, J. N.Giroux, M.Karch, C. M.Boctor, D.Storm, N. J.Diaz, A.Zekanowski, C.Kang, A. A.Hinman, C.Cerovac, V.Guzman, E.Zhou, H.Goate, A.Fisher, S. K.Cuervo, A. M.Kosik, K. S.2018-12-18doi:10.1101/500801Cold Spring Harbor Laboratory Press2018-12-18
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Cai, Y.Yu, S.Jangra, R.Postnikova, E.Wada, J.Tesh, R.Whelan, S.Lauck, M.Wiley, M.Finch, C.Radoshitzky, S.O'Connor, D.Palacios, G.Chandran, K.Chiu, C.Kuhn, J.2018-12-27doi:10.1101/507350Cold Spring Harbor Laboratory Press2018-12-27
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Coen-Cagli, R.Solomon, S. S.2018-12-31doi:10.1101/508838Cold Spring Harbor Laboratory Press2018-12-31
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Chen, G.-Y.Asenjo, A. B.Chen, Y.Mascaro, J.Arginteanu, D. F. J.Sosa, H. J.Hancock, W. O.2019-01-14doi:10.1101/520072Cold Spring Harbor Laboratory Press2019-01-14
https://biorxiv.org/cgi/content/short/528232v1?rss=1"
Zamith-Miranda, D.Heyman, H. M.Cleare, L. G.Couvillion, S. P.Clair, G. C.Bredeweg, E. L.Gacser, A.Nimrichter, L.Nakayasu, E. S.Nosanchuk, J. D.2019-01-23doi:10.1101/528232Cold Spring Harbor Laboratory Press2019-01-23
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Tsuboi, T.Viana, M. P.Xu, F.Yu, J.Chanchani, R.Arceo, X. G.Tutucci, E.Choi, J.Chen, Y. S.Singer, R. H.Rafelski, S. M.Zid, B. M.2019-01-25doi:10.1101/529289Cold Spring Harbor Laboratory Press2019-01-25
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Dong, X.Zhang, L.Hao, X.Wang, T.Vijg, J.2019-01-31doi:10.1101/535807Cold Spring Harbor Laboratory Press2019-01-31
https://biorxiv.org/cgi/content/short/535906v1?rss=1"
3,000 per cell in centenarians. We discovered mutational hotspot regions, some of which, as expected, located at immunoglobulin genes associated with somatic hypermutation. B cell-specific mutation signatures were observed associated with development, ageing or somatic hypermutation (SHM). The SHM signature strongly correlated with the signature found in human chronic lymphocytic leukemia and malignant B-cell lymphomas4, indicating that even in B cells of healthy individuals the potential cancer-causing events are already present. We also identified multiple mutations in sequence features relevant to cellular function, i.e., transcribed genes and gene regulatory regions. Such mutations increased significantly during ageing, but only at approximately half the rate of the genome average, indicating selection against mutations that impact B cell function. This first full characterization of the landscape of somatic mutations in human B lymphocytes indicates that spontaneous somatic mutations accumulating with age can be deleterious and may contribute to both the increased risk for leukemia and the functional decline of B lymphocytes in the elderly.
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Dong, X.Zhang, L.Brazhnik, K.Lee, M.Hao, X.Maslov, A. Y.Zhang, Z.Wang, T.Vijg, J.2019-01-31doi:10.1101/536896Cold Spring Harbor Laboratory Press2019-01-31
https://biorxiv.org/cgi/content/short/546010v1?rss=1"
90% of the COs that arise in mammalian meiosis. We generated a point mutation in the ATP binding motif of Msh5, and found that mutant spermatocytes lose all COs, not just those arising from the class I pathway.
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Brazhnik, K.Sun, S.Alani, O.Kinkhabwala, M.Wolkoff, A. W.Maslov, A. Y.Dong, X.Vijg, J.2019-02-14doi:10.1101/547893Cold Spring Harbor Laboratory Press2019-02-14
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Biro, D.Pechuan, X.Bergman, A.Lambros, M.2019-02-19doi:10.1101/553982Cold Spring Harbor Laboratory Press2019-02-19
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Bürgel, P. H.Marina, C. L.Saavedra, P. H. V.Albuquerque, P.Holanda, P. H.Castro, R. d. A.Heyman, H.Coelho, C.Cordero, R. J. B.Casadevall, A.Nosanchuk, J.Nakayasu, E.May, R. C.Tavares, A. H.Bocca, A.2019-02-19doi:10.1101/554048Cold Spring Harbor Laboratory Press2019-02-19
https://biorxiv.org/cgi/content/short/554410v1?rss=1"
Delpu, Y.McNamara, T. F.Griffin, P.Kaleem, S.Narayan, S.Schildkraut, C.Miga, K. H.Tahiliani, M.2019-02-19doi:10.1101/554410Cold Spring Harbor Laboratory Press2019-02-19
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Auslander, N.Heselmeyer-Haddad, K.Patkar, S.Hirsch, D.Camps, J.Brown, M.Bronder, D.Chen, W.-D.Lokanga, R.Wangsa, D.Wangsa, D.Hu, Y.Lischka, A.Braun, R.Emons, G.Ghadimi, B. M.Gaedcke, J.Grade, M.Montagna, C.Lazebnik, Y.Difilippantonio, M. J.Habermann, J. K.Auer, G.Ruppin, E.ried, t.2019-03-01doi:10.1101/563858Cold Spring Harbor Laboratory Press2019-03-01
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Crosse, M. J.Foxe, J. J.Molholm, S.2019-03-01doi:10.1101/565333Cold Spring Harbor Laboratory Press2019-03-01
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Kamal, M.Moshiri, H.Magomedova, L.Han, D.Nguyen, K. C.Yeo, M.Knox, J.Bagg, R.Won, A. M.Szlapa, K.Yip, C.Cummins, C. L.Hall, D. H.Roy, P. J.2019-03-03doi:10.1101/565473Cold Spring Harbor Laboratory Press2019-03-03
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Basharat, A.Barnett-Cowan, M.Mahoney, J. R.2019-03-01doi:10.1101/565507Cold Spring Harbor Laboratory Press2019-03-01
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Devlin, L.Perkins, G.Bowen, J. R.Montagna, C.Spiliotis, E. T.2019-03-05doi:10.1101/566513Cold Spring Harbor Laboratory Press2019-03-05
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van Dierendonck, X. A. M. H.de la Rosa Rodriguez, M. A.Georgiadi, A.Mattijssen, F.Dijk, W.van Weeghel, M.Singh, R.Borst, J. W.Stienstra, R.Kersten, S.2019-03-05doi:10.1101/566802Cold Spring Harbor Laboratory Press2019-03-05
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Brima, T. J.Molholm, S.Molloy, C. J.Sysoeva, O. V.Nicholas, E.Djukic, A.Freedman, E.Foxe, J. J.2019-03-05doi:10.1101/568832Cold Spring Harbor Laboratory Press2019-03-05
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Alves, L. R.Peres da Silva, R.Sanchez, D. A.Zamith-Miranda, D.Rodrigues, M. L.Goldenberg, S.Puccia, R.Nosanchuk, J. D.2019-03-07doi:10.1101/570291Cold Spring Harbor Laboratory Press2019-03-07
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Humphrey, J. M.Mpofu, P.Pettit, A. C.Musick, B.Carter, E. J.Messou, E.Marcy, O.Crabtree-Ramirez, B.Yotebieng, M.Anastos, K.Sterling, T. R.Yiannoutsos, C.Diero, L.Wools-Kaloustian, K.See S8 Table,2019-03-08doi:10.1101/571000Cold Spring Harbor Laboratory Press2019-03-08
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de Torrente, L.Zimmerman, S.Suzuki, M.Christopeit, M.Greally, J. M.Mar, J.2019-03-09doi:10.1101/572693Cold Spring Harbor Laboratory Press2019-03-09
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Burke, K. M.Molholm, S.Butler, J. S.Ross, L. A.Foxe, J. J.2019-03-18doi:10.1101/581777Cold Spring Harbor Laboratory Press2019-03-18
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Jordan, S.Tung, N.Casanova-Acebes, M.Chang, C.Cantoni, C.Zhang, D.Wirtz, T. H.Naik, S.Rose, S. A.Brocker, C. N.Gainullina, A.Maier, B. B.LeRoith, D.Gonzalez, F. J.Meissner, F.Ochando, J.Rahman, A.Chipuk, J. E.Artyomov, M. N.Frenette, P. S.Piccio, L.Berres, M.-L.Gallagher, E. J.Merad, M.2019-03-21doi:10.1101/582346Cold Spring Harbor Laboratory Press2019-03-21
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Chang, W. K.Kelly, L.2019-03-21doi:10.1101/584201Cold Spring Harbor Laboratory Press2019-03-21
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Noel, J.-P.Ishizawa, Y.Patel, S.Eskandar, E.Wallace, M.2019-03-21doi:10.1101/584516Cold Spring Harbor Laboratory Press2019-03-21
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Munguba, H.Nikouei, K.Hochgerner, H.Oberst, P.Kouznetsova, A.Ryge, J.Bastista-Brito, R.Munoz-Manchado, A. B.Close, J.Linnarsson, S.Hjerling Leffler, J.2019-03-31doi:10.1101/593285Cold Spring Harbor Laboratory Press2019-03-31
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Pechuan, X.Biro, D.Lambros, M.Bergman, A.2019-04-05doi:10.1101/598995Cold Spring Harbor Laboratory Press2019-04-05
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Selvanesan, B. C.Chandra, D.Quispe-Tintaya, W.Jahangir, A.Patel, A.Meena, K.Alberto Alves Da Silva, R.Libutti, S. K.Yuan, Z.Beck, A.Tesfa, L.Koba, W.Chuy, J.McAuliffe, J. C.Jafari, R.Entenberg, D.Wang, Y.Condeelis, J.Gravekamp, C.2019-04-05doi:10.1101/600106Cold Spring Harbor Laboratory Press2019-04-05
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Goren, L.Zhang, G.Kaushik, S.Breslin, P. A.Du, Y.-C. N.Foster, D. A.2019-04-15doi:10.1101/610097Cold Spring Harbor Laboratory Press2019-04-15
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Olivier, E. E.Zhang, S.Yan, Z.Suzuka, S.Roberts, K. E.Wang, K. E.Bouhassira, E. E.2019-04-23doi:10.1101/616748Cold Spring Harbor Laboratory Press2019-04-23
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Zhang, S. E.Olivier, E. E.Yan, Z. E.Suzuka, S. E.Roberts, K. E.Wang, K. E.Bouhassira, E. E.2019-04-25doi:10.1101/616755Cold Spring Harbor Laboratory Press2019-04-25
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Drelon, C.Belalcazar, H. M.Secombe, J.2019-04-24doi:10.1101/617985Cold Spring Harbor Laboratory Press2019-04-24
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Biswas, J.Patel, V. L.Bhaskar, V.Chao, J. A.Singer, R. H.Eliscovich, C.2019-04-25doi:10.1101/618587Cold Spring Harbor Laboratory Press2019-04-25
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Karavani, E.Zuk, O.Zeevi, D.Atzmon, G.Barzilai, N.Stefanis, N. C.Hatzimanolis, A.Smyrnis, N.Avramopoulos, D.Kruglyak, L.Lam, M.Lencz, T.Carmi, S.2019-05-05doi:10.1101/626846Cold Spring Harbor Laboratory Press2019-05-05
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Van Arsdale, A.Patterson, N. E.Maggi, E. C.Agoni, L.Van Doorslaer, K.Harmon, B.Nevadunsky, N.Kuo, D. Y. S.Einstein, M. H.Lenz, J.Montagna, C.2019-05-10doi:10.1101/634857Cold Spring Harbor Laboratory Press2019-05-10
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Kana, V.Desland, F. A.Casanova-Acebes, M.Ayata, P.Badimon, A.Nabel, E.Yamamuro, K.Sneeboer, M.Tan, I.-L.Flanigan, M.Rose, S. A.Chang, C.Leader, A.LeBourhis, H.Sweet, E.Tung, N.Wroblewska, A.Lavin, Y.See, P.Baccarini, A.Ginhoux, F.Chitu, V.Stanley, E. R.Russo, S.Yue, Z.Brown, B.Joyner, A. L.De Witte, L.Morishita, H.Schaefer, A.Merad, M.2019-05-17doi:10.1101/639526Cold Spring Harbor Laboratory Press2019-05-17
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dos Santos Correa, M.dos Santos Vaz, B.Grisanti, G. D. V.de Paiva, J. P. Q.Tiba, P. A.Fornari, R. V.2019-05-24doi:10.1101/643098Cold Spring Harbor Laboratory Press2019-05-24
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Yu, B.Doni Jayavelu, N.Battle, S.Smith, T.Zimmerman, S. E.Mar, J. C.Schimmel, T.Cohen, J.Hawkins, R. D.2019-05-27doi:10.1101/651141Cold Spring Harbor Laboratory Press2019-05-27
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Cade, B. E.Lee, J.Sofer, T.Wang, H.Zhang, M.Chen, H.Gharib, S. A.Gottlieb, D. J.Guo, X.Lane, J. M.Liang, J.Lin, X.Mei, H.Patel, S. R.Purcell, S. M.Saxena, R.Shah, N. A.Evans, D. S.Hanis, C. L.Hillman, D. R.Mukherjee, S.Palmer, L. J.Stone, K. L.Tranah, G. J.NHLBI Trans-Omics for Precision Medicine (TOPMed),Abecasis, G.Boerwinkle, E.Correa, A.Cupples, L. A.Kaplan, R. C.Nickerson, D. A.North, K. E.Psaty, B. M.Rotter, J. I.Rich, S. S.Tracy, R. P.Vasan, R. S.Wilson, J. G.Zhu, X.Redline, S.TOPMed Sleep Working Group,2019-06-03doi:10.1101/652966Cold Spring Harbor Laboratory Press2019-06-03
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Sysoeva, O. V.Molholm, S.Djukic, A.Frey, H.-P.Foxe, J. J.2019-05-30doi:10.1101/653246Cold Spring Harbor Laboratory Press2019-05-30
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Baldassari, A. R.Avery, C. L.Highland, H. M.Arking, D. R.Buyske, S.Darbar, D.Gondalia, R.Graff, M. R.Guo, X. R.Heckbert, S. R.Hindorff, L. A.Hodonsky, C. J.Ida Chen, Y.-D.Kaplan, R. C.Peters, U.Post, W.Reiner, A. P.Shohet, R. V.Sotoodehnia, N.Tao, R.Taylor, K. D.Yao, J. D.Kenny, E. D.Lin, H. J.Soliman, E. Z.Whitsel, E. A.North, K. E.Kooperberg, C.Rotters, j.Seyerle, A. A.2019-05-31doi:10.1101/654012Cold Spring Harbor Laboratory Press2019-05-31
https://biorxiv.org/cgi/content/short/655969v1?rss=1"
Nelson, K. N.Gandhi, N. R.Mathema, B.Lopman, B.Brust, J. C.Auld, S. C.Ismail, N.Omar, S. V.Brown, T. S.Allana, S.Campbell, A.Moodley, P.Mlisana, K.Shah, N. S.Jenness, S. M.2019-06-07doi:10.1101/655969Cold Spring Harbor Laboratory Press2019-06-07
https://biorxiv.org/cgi/content/short/659466v1?rss=1"
Heifets, B. D.Salgado, J. S.Taylor, M. D.Hoerbelt, P.Cardozo Pinto, D. F.Walsh, J. J.Steinberg, E. E.Sze, J. Y.Malenka, R. C.2019-06-03doi:10.1101/659466Cold Spring Harbor Laboratory Press2019-06-03
https://biorxiv.org/cgi/content/short/668467v1?rss=1"
T and T>C transitions. By comparing it to human cancer signatures, we not only confirmed the inferred MMR-deficiency-related etiology of several cancer signatures but also suggested that MMR deficiency is likely the cause of a cancer signature with its etiology previously unknown. We also observed a 7-fold increase of somatic small insertions and deletions (INDELs) in the Msh2-/- mice. An elevated INDEL frequency has also been found in human MMR-related cancers. INDELs and SNVs distributed differently across genomic features in the Msh2-/- and control cells, with evidence of selection pressure and repair preference. These results provide insights into the landscape of somatic mutations in normal somatic cells caused by MMR deficiency.nnSignificanceOur results show that MMR deficiency in the mouse is associated with a much lower elevation of somatic mutation rates than previously reported and provides the first MMR whole-genome mutational landscapes in normal somatic cells in vivo.
]]>Zhang, L.Dong, X.Hao, X.Lee, M.Chi, Z.Jin, B.Maslov, A. Y.Edelmann, W.Vijg, J.2019-06-12doi:10.1101/668467Cold Spring Harbor Laboratory Press2019-06-12
https://biorxiv.org/cgi/content/short/678037v1?rss=1"
Selyutina, A.Persaud, M.Bulnes-Ramos, A.Buffone, C.Scoca, V.Di Nunzio, F.Hiatt, J.Krogan, N. J.Hultquist, J. F.Diaz-Griffero, F.2019-06-21doi:10.1101/678037Cold Spring Harbor Laboratory Press2019-06-21
https://biorxiv.org/cgi/content/short/682476v1?rss=1"
Qi, H. H.Liu, Q.Borcherding, N.Shao, P.Maina, P. K.Zhang, W.2019-06-25doi:10.1101/682476Cold Spring Harbor Laboratory Press2019-06-25
https://biorxiv.org/cgi/content/short/686840v1?rss=1"
Domingos, P. M.Jenny, A.del Alamo, D.Mlodzik, M.Steller, H.Mollereau, B.2019-06-28doi:10.1101/686840Cold Spring Harbor Laboratory Press2019-06-28
https://biorxiv.org/cgi/content/short/688010v1?rss=1"
25%), most of which had never hitherto been implicated in immunology. Furthermore, they were conspicuously enriched in genes for which humans show poor tolerance to loss-of-function. The immunophenotyping platform also exposed dense correlation networks linking immune parameters with one another and with specific physiologic traits. By limiting the freedom of individual immune parameters, such linkages impose genetically regulated "immunological structures", whose integrity was found to be associated with immunocompetence. Hence, our findings provide an expanded genetic resource and structural perspective for understanding and monitoring immune variation in health and disease.
]]>Abeler-Dörner, L.Laing, A.Lorenc, A.Ushakov, D. S.Clare, S.Speak, A.Duque, M.White, J. K.Ramirez-Solis, R.Saran, N.Bull, K. R.Moron, B.Iwasaki, J.Barton, P. R.Caetano, S.Hng, K. I.Cambridge, E.Forman, S.Crockford, T. L.Griffiths, M.Kane, L.Harcourt, K.Brandt, C.Notley, G.Babalola, K. O.Warren, J.Mason, J. C.Meeniga, A.Karp, N. A.Melvin, D.Cawthorne, E.Weinrick, B.Rahim, A.Drissler, S.Meskas, J.Yue, A.Lux, M.Song-Zhao, G.Chan, A.Ballesteros Reviriego, C.Abeler, J.Wilson, H.Przemska-Kosicka, A.Edmans, M.Stre2019-07-02doi:10.1101/688010Cold Spring Harbor Laboratory Press2019-07-02
https://biorxiv.org/cgi/content/short/696021v1?rss=1"
A Francisco, A.J Foxe, J.J Horsthuis, D.DeMaio, D.Molholm, S.2019-07-09doi:10.1101/696021Cold Spring Harbor Laboratory Press2019-07-09
https://biorxiv.org/cgi/content/short/696195v1?rss=1"
Brook, C. E.Boots, M.Chandran, K.Dobson, A. P.Drosten, C.Graham, A. L.Grenfell, B.Müller, M. A.Ng, M.Wang, L.-F.van Leeuwen, A.2019-07-08doi:10.1101/696195Cold Spring Harbor Laboratory Press2019-07-08
https://biorxiv.org/cgi/content/short/697334v1?rss=1"
Autry, A. E.Wu, Z.Kohl, J.Bambah-Mukku, D.Rubinstein, N. D.Marin-Rodriguez, B.Carta, I.Sedwick, V.Dulac, C.2019-07-09doi:10.1101/697334Cold Spring Harbor Laboratory Press2019-07-09
https://biorxiv.org/cgi/content/short/715730v1?rss=1"
Akella, J. S.Carter, S. P.Rizvi, F.Nguyen, K. C. Q.Tsiropoulou, S.Moran, A. L.Silva, M.Kennedy, B. N.Hall, D. H.Barr, M. M.Blacque, O. E.2019-07-25doi:10.1101/715730Cold Spring Harbor Laboratory Press2019-07-25
https://biorxiv.org/cgi/content/short/723585v1?rss=1"
Kerkman, P. F.Dernstedt, A.Tadala, L.Mittler, E.Dannborg, M.Sundling, C.Maleki, K. T.Tauriainen, J.Tuiskunen-Back, A.Wigren Bystrom, J.Ocaya, P.Thunberg, T.Jangra, R.Roman-Sosa, G.Guardado-Calvo, P.Rey, F. A.Klingstrom, J.Chandran, K.Puhar, A.Ahlm, C.Forsell, M.2019-08-02doi:10.1101/723585Cold Spring Harbor Laboratory Press2019-08-02
https://biorxiv.org/cgi/content/short/726612v1?rss=1"
Hong, S.Feng, L.Jiang, H.Hou, X.Guo, P.Marlow, F.Stanley, P.Wu, P.2019-08-09doi:10.1101/726612Cold Spring Harbor Laboratory Press2019-08-09
https://biorxiv.org/cgi/content/short/726901v1?rss=1"
Khan, S.Kelly, L.2019-08-09doi:10.1101/726901Cold Spring Harbor Laboratory Press2019-08-09
https://biorxiv.org/cgi/content/short/729491v1?rss=1"
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org.highwire.dtl.DTLVardef@11317f1org.highwire.dtl.DTLVardef@88fffaorg.highwire.dtl.DTLVardef@5da692org.highwire.dtl.DTLVardef@62f6ed_HPS_FORMAT_FIGEXP M_FIG C_FIG
]]>Kang, W.Fan, Y.Du, Y.Tonkova, E. A.Hsu, Y.-H.Tan, K. V.Alexander, S.Wong, B. S.Yang, H.Luo, J.Yao, K.Yang, J.Hu, X.Liu, T.Gan, Y.Zhang, J.Zhao, J. J.Konstantopoulos, K.Friedl, P.Khong, P. L.Lu, A.Hung, M.-C.Brenner, M. B.Segall, J. E.Gu, Z.2019-08-09doi:10.1101/729491Cold Spring Harbor Laboratory Press2019-08-09
https://biorxiv.org/cgi/content/short/730135v1?rss=1"
Sheahan, A. V.Morel, K. L.Burkhart, D. L.Baca, S. C.Labbe, D. P.Roehle, K.Heckler, M.Calagua, C.Ye, H.Galbo, P.Panja, S.Mitrofanova, A.Hamid, A. A.Kibel, A. S.Choudhury, A. D.Pomerantz, M. M.Freedman, M. L.Sweeney, C. J.Dougan, S. K.Sowalsky, A.Loda, M.Olson, B. M.Ellis, L.2019-08-08doi:10.1101/730135Cold Spring Harbor Laboratory Press2019-08-08
https://biorxiv.org/cgi/content/short/739458v1?rss=1"
Aggarwal, R. K.Narang, A.2019-08-20doi:10.1101/739458Cold Spring Harbor Laboratory Press2019-08-20
https://biorxiv.org/cgi/content/short/743005v1?rss=1"
20-fold more enhancer:promoter (E:P) loops than in situ HiC. In addition to vasly improved identification of subkilobase-sized E:P loops, Tri-HiC also uncovered interaction stripes and contact domain insulation from promoters and enhancers, revealing their loop extrusion behaviors resembling the topologically-associated domain (TAD) boundaries. Tri-4C and Tri-HiC provide robust approaches to achieve the high resolution interactome maps required for characterizing fine-gage regulatory chromatin interactions in analysis of development, homeostasis and disease.
]]>Zhu, Y.Suh, Y.2019-08-22doi:10.1101/743005Cold Spring Harbor Laboratory Press2019-08-22
https://biorxiv.org/cgi/content/short/743328v1?rss=1"
De Sanctis, P.Malcolm, B. R.Mabie, P. C.Francisco, A. A.Mowrey, W. B.Joshi, S.Molholm, S.Foxe, J. J.2019-08-31doi:10.1101/743328Cold Spring Harbor Laboratory Press2019-08-31
https://biorxiv.org/cgi/content/short/743625v1?rss=1"
Teoh, J. J.Subramanian, N.Pero, M. E.Bartolini, F.Amador, A.Kanber, A.Williams, D.Petri, S.Yang, M.Allen, A. S.Beal, J.Haut, S. R.Frankel, W.2019-09-08doi:10.1101/743625Cold Spring Harbor Laboratory Press2019-09-08
https://biorxiv.org/cgi/content/short/746602v1?rss=1"
Mani, A.Li, H.Evrin, S.Redinbo, M. R.Mani, S.2019-08-24doi:10.1101/746602Cold Spring Harbor Laboratory Press2019-08-24
https://biorxiv.org/cgi/content/short/747642v1?rss=1"
Alves Francisco, A.Foxe, J. J.Horsthuis, D. J.Molholm, S.2019-08-28doi:10.1101/747642Cold Spring Harbor Laboratory Press2019-08-28
https://biorxiv.org/cgi/content/short/747956v1?rss=1"
Zeng, L.Yang, J.Peng, S.Zhu, J.Zhang, B.Suh, Y.Tu, Z.2019-08-28doi:10.1101/747956Cold Spring Harbor Laboratory Press2019-08-28
https://biorxiv.org/cgi/content/short/749010v1?rss=1"
1 independent signal. Fine-mapping at OBFC1 indicated the independent signals colocalized with cell-type specific eQTLs for OBFC1 (STN1). We further identified two novel genes, DCLRE1B (SNM1B) and PARN, using a multi-variant gene-based approach.
]]>Taub, M. A.Weinstock, J. S.Iyer, K. R.Yanek, L. R.Conomos, M. P.NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium,Reiner, A. P.Mathias, R. A.2019-09-04doi:10.1101/749010Cold Spring Harbor Laboratory Press2019-09-04
https://biorxiv.org/cgi/content/short/751115v1?rss=1"
Lehallier, B.Gate, D.Schaum, N.Nanasi, T.Lee, S. E.Yousef, H.Moran Losada, P.Berdnik, D.Keller, A.Verghese, J.Sathyan, S.Franceschi, C.Milman, S.Barzilai, N.Wyss-Coray, T.2019-09-01doi:10.1101/751115Cold Spring Harbor Laboratory Press2019-09-01
https://biorxiv.org/cgi/content/short/758557v1?rss=1"
Funabashi, M.Grove, T.Pascal, V.Varma, Y.McFadden, M.Brown, L.Guo, C.Medema, M. H.Almo, S.Fischbach, M. A.2019-09-05doi:10.1101/758557Cold Spring Harbor Laboratory Press2019-09-05
https://biorxiv.org/cgi/content/short/759886v1?rss=1"
Chen, W.De, A.Li, H.Lukin, D. J.Szymczak, W.Sun, K.Kelly, L.Wright, J. R.Lamendella, R.Ghosh, S.Kearns, D. B.He, Z.Jobin, C.Luo, X.Byju, A.Chatterjee, S.Yeoh, B. S.Vijay-Kumar, M.Tang, J. X.Mani, S.2019-09-08doi:10.1101/759886Cold Spring Harbor Laboratory Press2019-09-08
https://biorxiv.org/cgi/content/short/763482v1?rss=1"
Sollberger, G.Streeck, R.Caffrey, B. E.Zychlinsky, A.2019-09-09doi:10.1101/763482Cold Spring Harbor Laboratory Press2019-09-09
https://biorxiv.org/cgi/content/short/770743v1?rss=1"
Paulk, A. C.Yang, J. C.Cleary, D. R.Soper, D. J.Lee, S. H.Ganji, M.Ro, Y. G.Oh, H.Hossain, L.Rogers, N.Kilic, K.Ryu, S. B.Lee, S. W.Hermiz, J.Gilja, V.Lee, J. W.Maus, D.Devor, A.Fried, S. I.Jones, P. S.Nahed, B. V.Ben-Haim, S.Raslan, A. M. T.Siler, D. A.Cahill, D. P.Williams, Z. M.Cosgrove, G. R.Dayeh, S. A.Cash, S. S.2019-09-18doi:10.1101/770743Cold Spring Harbor Laboratory Press2019-09-18
https://biorxiv.org/cgi/content/short/775353v1?rss=1"
Bonhoure, N.Praz, V.Moir, R. D.Willemin, G.Mange, F.Moret, C.Willis, I. M.Hernandez, N.2019-09-19doi:10.1101/775353Cold Spring Harbor Laboratory Press2019-09-19
https://biorxiv.org/cgi/content/short/780668v1?rss=1"
Belbin, G. M.Wenric, S.Cullina, S.Glicksberg, B. S.Moscati, A.Wojcik, G. L.Shemirani, R.Beckmann, N. D.Cohain, A.Sorokin, E. P.Park, D. S.Ambite, J.-L.Ellis, S.Auton, A.CBIPM Genomics Team,Regeneron Genetics Center,Bottinger, E. P.Cho, J. H.Loos, R. J.Abul-Husn, N. S.Zaitlen, N. A.Gignoux, C. R.Kenny, E. E.2019-09-24doi:10.1101/780668Cold Spring Harbor Laboratory Press2019-09-24
https://biorxiv.org/cgi/content/short/781005v1?rss=1"
Khodakhah, K.Washburn, S.Freemont, R.Moreno-Escobar, M. C.Angueyra, C.2019-09-25doi:10.1101/781005Cold Spring Harbor Laboratory Press2019-09-25
https://biorxiv.org/cgi/content/short/782748v1?rss=1"
Bick, A. G.Weinstock, J.Nandakumar, S. K.Fulco, C. P.Leventhal, M. J.Bao, E. L.Nasser, J.Zekavat, S. M.Szeto, M. D.Laurie, C.Taub, M.Mitchell, B.Barnes, K.Moscati, A.Fornage, M.Redline, S.Psaty, B. M.Silverman, E.Weiss, S.Palmer, N.Ramachandran, V.Burchard, E.Kardia, S.He, J.Kaplan, R.Smith, N. L.Arnett, D.Schwartz, D.Correa, A.de Andrade, M.Guo, X.Konkle, B. A.Custer, B.Peralta, J.Gui, H.Meyers, D.McGarvey, S. T.Chen, I.Shoemaker, M. B.Peyser, P. A.Broome, J.Gogarten, S.Wang, F. F.Wong, Q.Montasser, M.Da2019-09-27doi:10.1101/782748Cold Spring Harbor Laboratory Press2019-09-27
https://biorxiv.org/cgi/content/short/784009v1?rss=1"
Maldonado, O.Jenkins, A.Belalcazar, H. M.Hernandez-Cuervo, H.Ladaga, G.Padilla, L.de Erausquin, G. A.2019-09-26doi:10.1101/784009Cold Spring Harbor Laboratory Press2019-09-26
https://biorxiv.org/cgi/content/short/785931v1?rss=1"
Cocanougher, B. T.Wittenbach, J. D.Long, X.Kohn, A. B.Norekian, T. P.Yan, J.Colonell, J.Masson, J.-B.Truman, J. W.Cardona, A.Turaga, S.Singer, R. H.Moroz, L. L.Zlatic, M.2019-09-30doi:10.1101/785931Cold Spring Harbor Laboratory Press2019-09-30
https://biorxiv.org/cgi/content/short/792671v1?rss=1"
Dvorak, Z.Felix Kopp, F.Costello, C. M.Kemp, J. S.Li, H.Vrzalova, A.Stepankova, M.Iveta Bartonkov, I.Poulikova, K.Vyhlidalova, B.Nordstroem, L. U.Karunaratne, C.Ranhotra, H.Mun, K. S.Naren, A. P.Murray, I.Perdew, G. H.Brtko, J.Toporova, L.Schon, A.Wallace, B.Walton, W. G.Redinbo, M. R.Sun, K.Beck, A.Kortagere, S.Neary, M. C.Chandran, A.Vishveshwara, S.Cavalluzzi, M. M.Lentini, G.Cui, J. Y.Gu, H.March, J. C.Chaterjee, S.Matson, A.Wright, D.Flannigan, K. L.Hirota, S. A.Mani, S.2019-10-04doi:10.1101/792671Cold Spring Harbor Laboratory Press2019-10-04
https://biorxiv.org/cgi/content/short/793380v1?rss=1"
Kim, S.-M.Liu, Y.Wang, Y.Karkashon, S.Lewis-Ballester, A.Yeh, S.-R.Correia, M. A.2019-10-04doi:10.1101/793380Cold Spring Harbor Laboratory Press2019-10-04
https://biorxiv.org/cgi/content/short/794487v1?rss=1"
Byju, A.Patel, D.Chen, W.Mani, S.2019-10-07doi:10.1101/794487Cold Spring Harbor Laboratory Press2019-10-07
https://biorxiv.org/cgi/content/short/802710v1?rss=1"
Henry, C. A.Jazayeri, M.Shapley, R. M.Hawken, M. J.2019-10-13doi:10.1101/802710Cold Spring Harbor Laboratory Press2019-10-13
https://biorxiv.org/cgi/content/short/808170v1?rss=1"
Vormstein-Schneider, D. C.Lin, J. D.Pelkey, K. A.Chittajallu, R.Guo, B.Arias Garcia, M.Sakopoulos, S.Stevenson, O.Schneider, G.Zhang, Q.Sharma, J.Franken, T. P.Smith, J.Vogel, I.Sanchez, V.Ibrahim, L. A.Burbridge, T.Favuzzi, E.Saldi, G. A.Xu, Q.Guo, L.Yuan, X.Zaghloul, K. A.Sabri, E.Goldberg, E. M.Devinsky, O.Batista-Brito, R.Reynolds, J.Feng, G.Fu, Z.McBain, C. J.Fishell, G. J.Dimidschstein, J.2019-10-18doi:10.1101/808170Cold Spring Harbor Laboratory Press2019-10-18
https://biorxiv.org/cgi/content/short/809145v1?rss=1"
Jin, H.Emmons, S. W.Kim, B.2019-10-17doi:10.1101/809145Cold Spring Harbor Laboratory Press2019-10-17
https://biorxiv.org/cgi/content/short/813279v1?rss=1"
Midega, T. D.Filho, N. C. V. L.Nassar, A. P.Alencar, R. M.Neto, A. C.Ferraz, L. R.Correa, T. D.2019-10-21doi:10.1101/813279Cold Spring Harbor Laboratory Press2019-10-21
https://biorxiv.org/cgi/content/short/818195v1?rss=1"
Akintayo, A.Liang, M.Bartholdy, B.Batista, F.Aguilan, J.Prendergast, J.Sundaram, S.Stanley, P.2019-10-28doi:10.1101/818195Cold Spring Harbor Laboratory Press2019-10-28
https://biorxiv.org/cgi/content/short/822007v1?rss=1"
Snipas, M.Kraujalis, T.Maciunas, K.Kraujaliene, L.Gudaitis, L.Verselis, V. K.2019-10-29doi:10.1101/822007Cold Spring Harbor Laboratory Press2019-10-29
https://biorxiv.org/cgi/content/short/829606v1?rss=1"
Biswas, J.Rahman, R.Gupta, V.Rosbash, M.Singer, R.2019-11-04doi:10.1101/829606Cold Spring Harbor Laboratory Press2019-11-04
https://biorxiv.org/cgi/content/short/833582v1?rss=1"
Faria, A. C. O.Caraciolo, M.Minillo, R. M.Almeida, T. F.Pereira, S. M.Cervato, M. C.Oliveira, J. B.2019-11-07doi:10.1101/833582Cold Spring Harbor Laboratory Press2019-11-07
https://biorxiv.org/cgi/content/short/835793v1?rss=1"
Ferri-Borgogno, S.Barui, S.McGee, A. M.Griffiths, T.Singh, P. K.Piett, C. G.Ghosh, B.Bhattacharyya, S.Singhi, A.Pradhan, K.Verma, A.Nagel, Z.Maitra, A.Gupta, S.2019-11-08doi:10.1101/835793Cold Spring Harbor Laboratory Press2019-11-08
https://biorxiv.org/cgi/content/short/836288v1?rss=1"
Pai, V. J.Lu, R.Wu, L.Garcia-Macia, M.Koba, W. R.Chi, Y.Singh, R.Schwartz, G. J.Schuster, V. L.2019-11-09doi:10.1101/836288Cold Spring Harbor Laboratory Press2019-11-09
https://biorxiv.org/cgi/content/short/842724v1?rss=1"
Montijn, J. S.Liu, R. G.Aschner, A.Kohn, A.Latham, P. E.Pouget, A.2019-11-15doi:10.1101/842724Cold Spring Harbor Laboratory Press2019-11-15
https://biorxiv.org/cgi/content/short/843177v1?rss=1"
95% of associated fusion proteins still permits enough active-protein cooperation to induce membrane merger. Experiments with Ebola virus-like particles show that resistance to antibody pressure is a conserved feature of filamentous particles. Our results offer a strategy for averting drug resistance or immune evasion by targeting filamentous virus particles.
]]>Li, T.Li, Z.Liu, M.Deans, E. E.Ivanovic, T.2019-11-15doi:10.1101/843177Cold Spring Harbor Laboratory Press2019-11-15
https://biorxiv.org/cgi/content/short/859132v1?rss=1"
Vorländer, M. K.Baudin, F.Moir, R. D.Wetzel, R.Hagen, W. J. H.Willis, I. M.Müller, C. W.2019-11-29doi:10.1101/859132Cold Spring Harbor Laboratory Press2019-11-29
https://biorxiv.org/cgi/content/short/868513v1?rss=1"
Cook, S. J.Crouse, C. M.Yemini, E.Hall, D. H.Emmons, S. W.Hobert, O.2019-12-08doi:10.1101/868513Cold Spring Harbor Laboratory Press2019-12-08
https://biorxiv.org/cgi/content/short/2022.03.17.484800v1?rss=1"
Choi, J.Zhang, X.Li, W.Houston, M.Peregrina, K.Dubin, R.Ye, K.Augenlicht, L.2022-03-19doi:10.1101/2022.03.17.484800Cold Spring Harbor Laboratory Press2022-03-19
https://biorxiv.org/cgi/content/short/2022.03.21.485194v1?rss=1"
Tanwar, A.Stanley, P.2022-03-21doi:10.1101/2022.03.21.485194Cold Spring Harbor Laboratory Press2022-03-21
https://biorxiv.org/cgi/content/short/2022.03.23.485508v1?rss=1"
Watanabe, H.Du, W.Son, J.Sui, L.Asahara, S.-i.Kurland, I. J.Kuo, T.Kitamoto, T.Miyachi, Y.de Cabo, R.Accili, D.2022-03-26doi:10.1101/2022.03.23.485508Cold Spring Harbor Laboratory Press2022-03-26
https://biorxiv.org/cgi/content/short/2022.03.31.485431v1?rss=1"
Soma, S.Ohara, S.Nonomura, S.Yoshida, J.Suematsu, N.Pastalkova, E.Sakai, Y.Tsutsui, K.-I.Isomura, Y.2022-04-01doi:10.1101/2022.03.31.485431Cold Spring Harbor Laboratory Press2022-04-01
https://biorxiv.org/cgi/content/short/2022.04.03.486895v1?rss=1"
Fried, J.Paul, M.Jing, Z.Fooksman, D.Lauvau, G.2022-04-03doi:10.1101/2022.04.03.486895Cold Spring Harbor Laboratory Press2022-04-03
https://biorxiv.org/cgi/content/short/2022.04.01.486754v1?rss=1"
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org.highwire.dtl.DTLVardef@139d8dborg.highwire.dtl.DTLVardef@cc1fd3org.highwire.dtl.DTLVardef@13d9086org.highwire.dtl.DTLVardef@db69bf_HPS_FORMAT_FIGEXP M_FIG A. Depiction represents multiple ERBB2 expressing cancer cells with stable 3UTR ARE and the signaling cascade known to cause chemo resistance. B. Depiction of the engineered destabilized 3UTR ARE of ERBB2 and the destabilization and degradation of the ERBB2 transcript, protein and kinases involved in mediation of drug resistance
C_FIG
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Lubiana, T.Dias, T. L.Peixe, D. G.Nakaya, H. T. I.2022-09-17doi:10.1101/2022.09.15.508149Cold Spring Harbor Laboratory Press2022-09-17
https://biorxiv.org/cgi/content/short/2022.09.18.508392v1?rss=1"
Mihnev, A.Amtmann, A.Cogdell, R.McKenzie, D.2022-09-18doi:10.1101/2022.09.18.508392Cold Spring Harbor Laboratory Press2022-09-18
https://biorxiv.org/cgi/content/short/2022.09.16.508266v1?rss=1"
Zhang, L.De Cecco, M.Lee, M.Hao, X.Maslov, A. Y.Montagna, C.Campisi, J.Dong, X.Sedivy, J. M.Vijg, J.2022-09-19doi:10.1101/2022.09.16.508266Cold Spring Harbor Laboratory Press2022-09-19
https://biorxiv.org/cgi/content/short/2022.09.20.508746v1?rss=1"
Thinwa, J. W.Zou, Z.Parks, E.Sebti, S.Hui, K.Singh, V.Wei, Y.Urquhart, G.Jewell, J. L.Pfeiffer, J. K.Levine, B.Reese, T. A.Shiloh, M. U.2022-09-20doi:10.1101/2022.09.20.508746Cold Spring Harbor Laboratory Press2022-09-20
https://biorxiv.org/cgi/content/short/2022.09.20.508741v1?rss=1"
Speranza, L.Filiz, K. D.Goebel, S.Perrone-Capano, C.Pulcrano, S.Volpicelli, F.Francesconi, A.2022-09-22doi:10.1101/2022.09.20.508741Cold Spring Harbor Laboratory Press2022-09-22
https://biorxiv.org/cgi/content/short/2022.09.22.509050v1?rss=1"
Mihnev, A.Amtmann, A.2022-09-23doi:10.1101/2022.09.22.509050Cold Spring Harbor Laboratory Press2022-09-23
https://biorxiv.org/cgi/content/short/2022.09.22.509080v1?rss=1"
40 days) of cells in 3D spheroids, our model enables to monitor the recovery of approximately the same cells that underwent treatment, demonstrating that NaBut does not have long-lasting effects on histone acetylation and gene expression. These results suggest that histone acetylation has minimal epigenetics memory in our spheroids culture.
ConclusionTogether, we established an innovative cell culture system that can be used to model anomalously decondensing chromatin in physiological cell growth and rule out epigenetics inheritance if cells recover the original phenotype after treatment. The transient epigenetics effects demonstrated here highlights the relevance of using a 3D culture model system that could be very useful in studies requiring long term drug treatment conditions that would not be possible using a 2D cell monolayer system.
]]>Stransky, S.Cutler, R.Aguilan, J.Nieves, E.Sidoli, S.2022-09-23doi:10.1101/2022.09.22.509080Cold Spring Harbor Laboratory Press2022-09-23
https://biorxiv.org/cgi/content/short/2022.09.27.509791v1?rss=1"
Schaan Profes, M.Tiroumalechetty, A.Patel, N.Lauar, S. S.Sidoli, S.Kurshan, P.2022-09-28doi:10.1101/2022.09.27.509791Cold Spring Harbor Laboratory Press2022-09-28
https://biorxiv.org/cgi/content/short/2022.09.29.510116v1?rss=1"
Shadron, K. K.Pena, J. L.2022-09-29doi:10.1101/2022.09.29.510116Cold Spring Harbor Laboratory Press2022-09-29
https://biorxiv.org/cgi/content/short/2022.09.30.507111v1?rss=1"
Zhao, Y.Wang, Y.Shi, L.McDonald-McGinn, D. M.Crowley, T. B.McGinn, D. E.Tran, O. T.Miller, D.Zackai, E.Johnston, H. R.Chow, E.Vorstman, J. A. S.Vingerhoets, C.van Amelsvoort, T.Gothelf, D.Swillen, A.Breckpot, J.Vermeesch, J. R.Eliez, S.Schneider, M.van den Bree, M. B.Owen, M. J.Kates, W.Repetto, G. M.Shashi, V.Schoch, K.Bearden, C. E.Digilio, M. C. E.Unolt, M.Putotto, C.Marino, B.Pontillo, M.Armando, M.Vicari, S.Angkustsiri, K.Campbell, L.Busa, T.Heine-Suner, D.Murphy, K. C.Murphy, D.Garcia-Minaur, S.Fernandez, L2022-10-03doi:10.1101/2022.09.30.507111Cold Spring Harbor Laboratory Press2022-10-03
https://biorxiv.org/cgi/content/short/2022.10.02.510540v1?rss=1"
Boutet, M.Erler, P.Nishitani, K.Couturier, N.Zhang, Z.Barbieux, E.Guillen, E.Suzuki, M.Lauvau, G.Guo, W.2022-10-05doi:10.1101/2022.10.02.510540Cold Spring Harbor Laboratory Press2022-10-05
https://biorxiv.org/cgi/content/short/2022.10.03.510675v1?rss=1"
Melo, G. A.Xu, T.Caloba, C.Schutte, A. W.Brum, G.Passos, T. O.Higa, L.Goncalves, A. N. A.Tanuri, A.Viola, J. P. B.Werneck, M. B. F.Nakaya, H.Pipkin, M. E.Martinez, G. J.Pereira, R. M.2022-10-07doi:10.1101/2022.10.03.510675Cold Spring Harbor Laboratory Press2022-10-07
https://biorxiv.org/cgi/content/short/2022.10.05.510967v1?rss=1"
An, W.Feola, M.Aluri, S.Ruiz-Martinez, M.Sridharan, A.Levy, M.Fibach, E.Zhu, X.Verma, A. K.Ginzburg, Y.2022-10-07doi:10.1101/2022.10.05.510967Cold Spring Harbor Laboratory Press2022-10-07
https://biorxiv.org/cgi/content/short/2022.10.14.512324v1?rss=1"
Celikgil, A.Massimi, A. B.Nakouzi, A.Herrera, N. G.Morano, N. C.Lee, J. H.Yoon, H. a.Garforth, S. J.Almo, S. C.2022-10-16doi:10.1101/2022.10.14.512324Cold Spring Harbor Laboratory Press2022-10-16
https://biorxiv.org/cgi/content/short/2022.10.17.512615v1?rss=1"
Emiliano, A.Kraljevic, M.Lopatinsky, N. R.Batista, R.Jiang, C.Schwartz, G. J.2022-10-21doi:10.1101/2022.10.17.512615Cold Spring Harbor Laboratory Press2022-10-21
https://biorxiv.org/cgi/content/short/2022.10.28.514255v1?rss=1"
Chioccioli, M.Magruder, S.McDonough, J. E.Nouws, J.Gonzalez, D.Borriello, L.Traub, B.Ye, X.Hendry, C. E.Entenberg, D.Kaminski, N.Krishnaswamy, S.Sauler, M.2022-10-30doi:10.1101/2022.10.28.514255Cold Spring Harbor Laboratory Press2022-10-30
https://biorxiv.org/cgi/content/short/2022.11.02.514812v1?rss=1"
Gilep, A.Varaksa, T.Bukhdruker, S.Kavaleuski, A.Ryzhykau, Y.Smolskaya, S.Sushko, T.Tsumoto, K.Grabovec, I.Kapranov, I.Okhrimenko, I.Marin, E.Shevtsov, M.Mishin, A.Kovalev, K.Kuklin, A.Gordeliy, V.Kaluzhskiy, L.Gnedenko, O.Yablokov, E.Ivanov, A.Borshchevskiy, V.Strushkevich, N.2022-11-02doi:10.1101/2022.11.02.514812Cold Spring Harbor Laboratory Press2022-11-02
https://biorxiv.org/cgi/content/short/2022.11.10.515925v1?rss=1"
Ranaivoson, F. M.Crozet, V.Benoit, M.Mohammed Khalid, A. A.Kikuti, C.Sirkia, H.El Marjou, A.Asenjo, A.Sosa, H.Schmidt, C.Rosenfeld, S.Houdusse, A.2022-11-10doi:10.1101/2022.11.10.515925Cold Spring Harbor Laboratory Press2022-11-10
https://biorxiv.org/cgi/content/short/2022.11.14.516438v1?rss=1"
Schneider, B. K.Sun, S.Lee, M.Li, W.Skvir, N.Neretti, N.Vijg, J.Secombe, J.2022-11-15doi:10.1101/2022.11.14.516438Cold Spring Harbor Laboratory Press2022-11-15
https://biorxiv.org/cgi/content/short/2022.11.17.516919v1?rss=1"
Reisli, S.Crosse, M. J.Molholm, S.2022-11-17doi:10.1101/2022.11.17.516919Cold Spring Harbor Laboratory Press2022-11-17
https://biorxiv.org/cgi/content/short/2022.11.20.517232v1?rss=1"
Yheskel, M.Sidoli, S.Secombe, J.2022-11-20doi:10.1101/2022.11.20.517232Cold Spring Harbor Laboratory Press2022-11-20
https://biorxiv.org/cgi/content/short/2022.11.23.517621v1?rss=1"
Carneiro, C. F. D.Costa, G.Neves, K.Abreu, M. B.Tan, P. B.Rayee, D.Boos, F.Andrejew, R.Lubiana, T.Malicki, M.Amaral, O. B.2022-11-24doi:10.1101/2022.11.23.517621Cold Spring Harbor Laboratory Press2022-11-24
https://biorxiv.org/cgi/content/short/2022.11.24.517880v1?rss=1"
Zheng, H.Vijg, J.Taherian Fard, A.Mar, J. C.2022-11-25doi:10.1101/2022.11.24.517880Cold Spring Harbor Laboratory Press2022-11-25
https://biorxiv.org/cgi/content/short/2022.12.06.519376v1?rss=1"
Viejo, G.Levenstein, D.Carrasco, S. S.Mehrotra, D.Mahallati, S.Vite, G. R.Denny, H.Sjulson, L.Battaglia, F. P.Peyrache, A.2022-12-07doi:10.1101/2022.12.06.519376Cold Spring Harbor Laboratory Press2022-12-07
https://biorxiv.org/cgi/content/short/2022.12.09.519776v1?rss=1"
Quezada, A.Ward, C.Bader, E. R.Zolotavin, P.Altun, E.Hong, S.Killian, N.Xie, C.Batista-Brito, R.Hebert, J. M.2022-12-11doi:10.1101/2022.12.09.519776Cold Spring Harbor Laboratory Press2022-12-11
https://biorxiv.org/cgi/content/short/2022.12.10.517707v1?rss=1"
Pathak, R.Eliscovich, C.Mena, I.Dixit, U.Garcia-Sastre, A.Singer, R.Kalpana, G. V.2022-12-12doi:10.1101/2022.12.10.517707Cold Spring Harbor Laboratory Press2022-12-12
https://biorxiv.org/cgi/content/short/2022.12.14.520402v1?rss=1"
Sella, Y.Broderick, N. A.Stouffer, K.McEwan, D. L.Ausubel, F. M.Casadevall, A.Bergman, A.2022-12-14doi:10.1101/2022.12.14.520402Cold Spring Harbor Laboratory Press2022-12-14
https://biorxiv.org/cgi/content/short/2022.12.15.520548v1?rss=1"
Martinez Lagunas, K.Savcigil, D. P.Zrilic, M.Carvajal Fraile, C.Craxton, A.Self, E.Uranga, I.de Miguel, D.Arias, M.Willenborg, S.Piekarek, M.Albert, M. C.Nugraha, K.Lisewski, I.Janakova, E.Igual, N.Tonnus, W.Hilendbrandt, X.Ibrahim, M.Ballegeer, M.Saelens, X.Kueh, A. J.Meier, P.Linkermann, A.Pardo, J.Eming, S.Walczak, H.MacFarlane, M.Peltzer, N.Annibaldi, A.2022-12-15doi:10.1101/2022.12.15.520548Cold Spring Harbor Laboratory Press2022-12-15
https://biorxiv.org/cgi/content/short/2022.12.21.521407v1?rss=1"
Chien, S.-C.Wang, P.Maess, B.Fishman, Y.Knoesche, T.2022-12-21doi:10.1101/2022.12.21.521407Cold Spring Harbor Laboratory Press2022-12-21
https://biorxiv.org/cgi/content/short/2022.12.22.521637v1?rss=1"
Bera, B. S.Thompson, T. V.Sosa, E.Nomaru, H.Reynolds, D.Dubin, R. A.Maqbool, S. B.Zheng, D.Morrow, B. E.Greally, J. M.Suzuki, M.2022-12-22doi:10.1101/2022.12.22.521637Cold Spring Harbor Laboratory Press2022-12-22
https://biorxiv.org/cgi/content/short/2023.01.03.522642v1?rss=1"
Duran, C. L.Karagiannis, G. S.Chen, X.Sharma, V. P.Entenberg, D.Condeelis, J. S.Oktay, M. H.2023-01-03doi:10.1101/2023.01.03.522642Cold Spring Harbor Laboratory Press2023-01-03
https://biorxiv.org/cgi/content/short/2023.01.07.522490v1?rss=1"
Borda, V.Loesch, D. P.Guo, B.Laboulaye, R.Veliz-Otani, D.French-Kwawu, J. N.Peixoto Leal, T.Gogarten, S. M.Ikpe, S.Gouveia, M. H.Mendes, M.Abecasis, G. R.Alvim, I.Arboleda-Bustos, C. E.Arboleda, G.Arboleda, H.Barreto, M. L.Barwick, L.Bezzera, M. A.Blangero, J.Borges, V.Caceres, O.Cai, J.Chana-Cuevas, P.Chen, Z.Custer, B.Dean, M.Dinardo, C.Domingos, I.Duggirala, R.Dieguez, E.Fernandez, W.Ferraz, H. B.Gilliland, F. D.Guio, H.Horta, B.Curran, J. E.Johnsen, J. M.Kaplan, R. C.Kelly, S.Kenny, E. E.Kittner, S.Konkle,2023-01-09doi:10.1101/2023.01.07.522490Cold Spring Harbor Laboratory Press2023-01-09
https://biorxiv.org/cgi/content/short/2023.01.12.523604v1?rss=1"
Tang, L. T. H.Lee, G. A.Cook, S. J.Ho, J.Potter, C. C.Buelow, H. E.2023-01-13doi:10.1101/2023.01.12.523604Cold Spring Harbor Laboratory Press2023-01-13
https://biorxiv.org/cgi/content/short/2023.01.12.523842v1?rss=1"
Marchand, T.Akinnola, K. E.Takeishi, S.Maryanovich, M.Pinho, S.Saint-Vanne, J.Birbrair, A.Lamy, T.Tarte, K.Frenette, P.Gritsman, K.2023-01-13doi:10.1101/2023.01.12.523842Cold Spring Harbor Laboratory Press2023-01-13
https://biorxiv.org/cgi/content/short/2023.01.18.524515v1?rss=1"
Binda, F.Spaeth, L.Kumar, A.Isope, P.2023-01-18doi:10.1101/2023.01.18.524515Cold Spring Harbor Laboratory Press2023-01-18
https://biorxiv.org/cgi/content/short/2023.01.21.525021v1?rss=1"
Bukavina, L.Ginwala, R.Sindhani, M.Prunty, M.Geynisman, D.Pooja, G.Valentine, H.Calaway, A.Brown, J. R.Correa, A.Mishra, K.Pominville, R.Plimack, E.Kutikov, A.Ghannoum, M.ElShaer, M.Retuerto, M.Uzzo, R.Ponsky, L.Abbosh, P. H.2023-01-23doi:10.1101/2023.01.21.525021Cold Spring Harbor Laboratory Press2023-01-23
https://biorxiv.org/cgi/content/short/2023.01.25.525428v1?rss=1"
90% allele concordance compared to long-read de-novo assemblies of well-characterized control samples. We demonstrate utility through significant associations between SVs and important various cardio-metabolic and hemotologic traits. We have identified 690 SV hotspots and deserts and those that potentially impact the regulation of medically relevant genes. This catalog characterizes SVs across multiple populations and will serve as a valuable tool to understand the impact of SV on disease development and progression.
]]>Jun, G.English, A. C.Metcalf, G. A.Yang, J.Chaisson, M. J.Pankratz, N.Menon, V. K.Salerno, W. J.Krasheninina, O.Smith, A. V.Lane, J. A.Blackwell, T.Kang, H. M.Salvi, S.Meng, Q.Shen, H.Pasham, D.Bhamidipati, S.Kottapalli, K.Arnett, D. K.Ashley-Koch, A.Auer, P. L.Beutel, K. M.Bis, J. C.Blangero, J.Bowden, D. W.Brody, J. A.Cade, B. E.Chen, Y.-D. I.Cho, M. H.Curran, J. E.Fornage, M.Freedman, B. I.Fingerlin, T.Gelb, B. D.Hou, L.Hung, Y.-J.Kane, J. P.Kaplan, R.Kim, W.Loos, R. J. F.Marcus,, G. M.Mathias, R. A.McGarv2023-01-26doi:10.1101/2023.01.25.525428Cold Spring Harbor Laboratory Press2023-01-26
https://biorxiv.org/cgi/content/short/2023.01.26.525812v1?rss=1"
Nandigrami, P.Fiser, A.2023-01-27doi:10.1101/2023.01.26.525812Cold Spring Harbor Laboratory Press2023-01-27
https://biorxiv.org/cgi/content/short/2023.01.31.526505v1?rss=1"
Einson, J.Glinos, D.Boerwinkle, E.Castaldi, P.Darbar, D.de Andrade, M.Ellinor, P.Fornage, M.Gabriel, S.Germer, S.Gibbs, R.Hersh, C.Johnsen, J.Kaplan, R.Konkle, B.Kooperberg, C.Nassir, R.Loos, R. J. F.Meyers, D. A.Mitchell, B. D.Psaty, B.Vasan, R. S.Rich, S. S.Rienstra, M.Rotter, J. I.Saferali, A.Shoemaker, M. B.Silverman, E.Smith, A. V.Mohammadi, P.Castel, S. E.Iossifov, I.Lappalainen, T.2023-01-31doi:10.1101/2023.01.31.526505Cold Spring Harbor Laboratory Press2023-01-31
https://biorxiv.org/cgi/content/short/2023.02.02.526913v1?rss=1"
Benoit, M. P. M. H.Rao, L.Asenjo, A. B.Gennerich, A.Sosa, H. J.2023-02-03doi:10.1101/2023.02.02.526913Cold Spring Harbor Laboratory Press2023-02-03
https://biorxiv.org/cgi/content/short/2023.02.13.528323v1?rss=1"
Kuzelova, A.Dupacova, N.Antosova, B.Sunny, S. S.Kozmik, Z.Paces, J.Skoultchi, A. I.Stopka, T.Kozmik, Z.2023-02-13doi:10.1101/2023.02.13.528323Cold Spring Harbor Laboratory Press2023-02-13
https://biorxiv.org/cgi/content/short/2023.02.13.528419v1?rss=1"
Xander, C.Rajagopalan, S.Jacobs, W. R.Braunstein, M.2023-02-14doi:10.1101/2023.02.13.528419Cold Spring Harbor Laboratory Press2023-02-14
https://biorxiv.org/cgi/content/short/2023.02.14.528512v1?rss=1"
Yang, N.Occean, J. R.Melters, D. P.Shi, C.Wang, L.Stransky, S.Doyle, M. E.Cui, C.-Y.Delannoy, M.Fan, J.Slama, E.Egan, J. M.De, S.Cunningham, S. C.Cabo, R. d.Sidoli, S.Dalal, Y.Sen, P.2023-02-15doi:10.1101/2023.02.14.528512Cold Spring Harbor Laboratory Press2023-02-15
https://biorxiv.org/cgi/content/short/2023.02.15.527913v1?rss=1"
Jing, Z.Galbo, P.Ovando, L.Demouth, M.Welte, S.Park, R.Chandran, K.Wu, Y.MacCarthy, T.Zheng, D.Fooksman, D.2023-02-15doi:10.1101/2023.02.15.527913Cold Spring Harbor Laboratory Press2023-02-15
https://biorxiv.org/cgi/content/short/2023.02.15.528714v1?rss=1"
Occean, J. R.Yang, N.Sun, Y.Dawkins, M. S.Munk, R.Belair, C.Dar, S.Anerillas, C.Wang, L.Shi, C.Dunn, C.Bernier, M.Price, N. L.Kim, J. S.Cui, C.-Y.Fan, J.Bhattacharyya, M.De, S.Maragkakis, M.Cabo, R. d.Sidoli, S.Sen, P.2023-02-15doi:10.1101/2023.02.15.528714Cold Spring Harbor Laboratory Press2023-02-15
https://biorxiv.org/cgi/content/short/2023.02.16.528161v1?rss=1"
Genna, A.Duran, C. L.Entenberg, D.Condeelis, J. S.Cox, D.2023-02-16doi:10.1101/2023.02.16.528161Cold Spring Harbor Laboratory Press2023-02-16
https://biorxiv.org/cgi/content/short/2023.02.25.530019v1?rss=1"
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org.highwire.dtl.DTLVardef@dc6d22org.highwire.dtl.DTLVardef@180f36borg.highwire.dtl.DTLVardef@ed341forg.highwire.dtl.DTLVardef@f8dfb2_HPS_FORMAT_FIGEXP M_FIG C_FIG
]]>Boddu, P. C.Gupta, A. K.Roy, R.De La Pena Avalos, B.Olazabal Herrero, A.Neuenkirchen, N.Zimmer, J.Chandhok, N. S.King, D.Nannya, Y.Ogawa, S.Lin, H.Simon, M.Dray, E.Kupfer, G.Verma, A. K.Neugebauer, K. M.Pillai, M. M.2023-02-26doi:10.1101/2023.02.25.530019Cold Spring Harbor Laboratory Press2023-02-26
https://biorxiv.org/cgi/content/short/2023.02.27.530366v1?rss=1"
Chowdhury, M. M.Samuel Zimmerman, S.Leeson, H.Nefzger, C.Mar, J. C.Laslett, A.Polo, J. M.Wolvetang, E. J.Cooper-White, J. J.2023-03-01doi:10.1101/2023.02.27.530366Cold Spring Harbor Laboratory Press2023-03-01
https://biorxiv.org/cgi/content/short/2023.03.03.531021v1?rss=1"
McDermott, K. D.Frechou, M. A.Jordan, J. T.Martin, S. S.Goncalves, J. T.2023-03-06doi:10.1101/2023.03.03.531021Cold Spring Harbor Laboratory Press2023-03-06
https://biorxiv.org/cgi/content/short/2023.03.07.531569v1?rss=1"
Luo, R.Yan, J.Oh, J. W.Xi, W.Shigaki, D.Wong, W.Cho, H.Murphy, D.Cutler, R.Rosen, B. P.Pulecio, J.Yang, D.Glenn, R.Chen, T.Li, Q. V.Vierbuchen, T.Sidoli, S.Apostolou, E.Huangfu, D.Beer, M. A.2023-03-09doi:10.1101/2023.03.07.531569Cold Spring Harbor Laboratory Press2023-03-09
https://biorxiv.org/cgi/content/short/2023.03.15.532613v1?rss=1"
Kharod, S. C.Hwang, D.Castillo, P. E.Yoon, Y. J.2023-03-15doi:10.1101/2023.03.15.532613Cold Spring Harbor Laboratory Press2023-03-15
https://biorxiv.org/cgi/content/short/2023.03.18.533278v1?rss=1"
Brown, A. J.Won, J.Wolfisberg, R.Fanhoe, U.Catanzaro, N.West, A.Moreira, F.Nogeuira Batista, M.Ferris, M. T.Linnertz, C.Leist, S. R.Nguyen, C.De la Cruz, G.Midkiff, B.Xia, Y.Montgomery, S. A.Billerbeck, E.Bukh, J.Scheel, T.Rice, C. M.Sheahan, T. P.2023-03-19doi:10.1101/2023.03.18.533278Cold Spring Harbor Laboratory Press2023-03-19
https://biorxiv.org/cgi/content/short/2023.03.20.530986v1?rss=1"
Ishigami, I.Sierra, R. G.Su, Z.Peck, A.Wang, C.Poitevin, F.Lisova, S.Hayes, B.Moss, F. R.Boutet, S.Sublett, R. E.Yoon, C. H.Yeh, S.-R.Rousseau, D. L.2023-03-22doi:10.1101/2023.03.20.530986Cold Spring Harbor Laboratory Press2023-03-22
https://biorxiv.org/cgi/content/short/2023.03.23.533915v1?rss=1"
Yim, H.Choe, D. T.Bae, J. A.Kang, H.-M.Nguyen, K. C. Q.Choi, M.-k.Ahn, S.Bahn, S.-k.Yang, H.Hall, D. H.Kim, J. S.Lee, J.2023-03-23doi:10.1101/2023.03.23.533915Cold Spring Harbor Laboratory Press2023-03-23
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View larger version (20K):
org.highwire.dtl.DTLVardef@139f4e5org.highwire.dtl.DTLVardef@1fd1a4eorg.highwire.dtl.DTLVardef@1ca17b4org.highwire.dtl.DTLVardef@da2b56_HPS_FORMAT_FIGEXP M_FIG C_FIG HighlightsO_LIThe microtubule severing enzyme FL2 RNA is localized to the leading edge
C_LIO_LIFL2 mRNA localization leads to FL2 translation within protrusions
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Wang, S.Falcone, R.Richmond, B.Averbeck, B.2023-09-17doi:10.1101/2023.09.17.558139Cold Spring Harbor Laboratory Press2023-09-17
https://biorxiv.org/cgi/content/short/2023.09.17.558147v1?rss=1"
Voelkel-Meiman, K.Poppel, A. J.Liddle, J. C.Balsbaugh, J. L.MacQueen, A. J.2023-09-17doi:10.1101/2023.09.17.558147Cold Spring Harbor Laboratory Press2023-09-17
https://biorxiv.org/cgi/content/short/2023.09.18.558337v1?rss=1"
Lorton, B. M.Warren, C.Ilyas, H.Nandigrami, P.Hegde, S.Cahill, S.Lehman, S. M.Shabanowitz, J.Hunt, D.Fiser, A.Cowburn, D.Shechter, D.2023-09-19doi:10.1101/2023.09.18.558337Cold Spring Harbor Laboratory Press2023-09-19
https://biorxiv.org/cgi/content/short/2023.09.19.558375v1?rss=1"
Paparella, A. S.Brew, I.Hong, H. A.Ferriera, W.Cutting, S.Lamiable-Oulaidi, F.Popadynec, M.Tyler, P. C.Schramm, V. L.2023-09-19doi:10.1101/2023.09.19.558375Cold Spring Harbor Laboratory Press2023-09-19
https://biorxiv.org/cgi/content/short/2023.09.27.559752v1?rss=1"
Astorkia, M.Liu, Y.Pedrosa, E.Lachman, H.Zheng, D.2023-09-27doi:10.1101/2023.09.27.559752Cold Spring Harbor Laboratory Press2023-09-27
https://biorxiv.org/cgi/content/short/2023.10.02.560432v1?rss=1"
Verhagen, M. P.Joosten, R.Schmitt, M.Valimaki, N.Sacchetti, A.Rajamaki, K.Choi, J.Procopio, P.Silva, S.van der Steen, B.van den Bosch, T. P. P.Seinstra, D.Doukas, M.Augenlicht, L. H.Aaltonen, L. A.Fodde, R.2023-10-04doi:10.1101/2023.10.02.560432Cold Spring Harbor Laboratory Press2023-10-04
https://biorxiv.org/cgi/content/short/2023.10.04.560841v1?rss=1"
Baker, N. E.Nair, S.2023-10-04doi:10.1101/2023.10.04.560841Cold Spring Harbor Laboratory Press2023-10-04
https://biorxiv.org/cgi/content/short/2023.10.11.561880v1?rss=1"
Cibelli, A.Dohare, P.Spray, D. C.Scemes, E.2023-10-12doi:10.1101/2023.10.11.561880Cold Spring Harbor Laboratory Press2023-10-12
https://biorxiv.org/cgi/content/short/2023.10.11.561944v1?rss=1"
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]]>Scanlon, L. R.Gabor, L.Khouri, O. R.Ahmad, S.Levy, E.Kuo, D. Y.-S.Lin, K.Nevadunsky, N.Gravekamp, C.2023-10-12doi:10.1101/2023.10.11.561944Cold Spring Harbor Laboratory Press2023-10-12
https://biorxiv.org/cgi/content/short/2023.10.11.561933v1?rss=1"
Sosa, E. A.Rosean, S.O'Shea, D.Raj, S. M.Seoighe, C.Greally, J. M.2023-10-16doi:10.1101/2023.10.11.561933Cold Spring Harbor Laboratory Press2023-10-16
https://biorxiv.org/cgi/content/short/2023.10.16.562559v1?rss=1"
Mulholland, C. V.Wiggins, T. J.Cui, J.Vilcheze, C.Rajagopalan, S.Shultis, M. W.Reyes-Fernandez, E. Z.Jacobs, W. R.Berney, M.2023-10-16doi:10.1101/2023.10.16.562559Cold Spring Harbor Laboratory Press2023-10-16
https://biorxiv.org/cgi/content/short/2023.10.18.563021v1?rss=1"
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org.highwire.dtl.DTLVardef@1045439org.highwire.dtl.DTLVardef@1357703org.highwire.dtl.DTLVardef@1189cf2org.highwire.dtl.DTLVardef@e7d574_HPS_FORMAT_FIGEXP M_FIG C_FIG
]]>Abbey, C. A.Duran, C. L.Chen, Z.Chen, Y.Roy, S.Coffell, A.Chakraborty, S.Wells, G. B.Chang, J.Bayless, K.2023-10-19doi:10.1101/2023.10.18.563021Cold Spring Harbor Laboratory Press2023-10-19
https://biorxiv.org/cgi/content/short/2023.10.21.563410v1?rss=1"
Dvorak, Z.Vyhlidalov, B.Pecinkov, P.Li, H.Anzenbacher, P.spicakova, a.anzenbacherova, e.Chow, V.LIU, J.Krause, H.Wilson, D. J.Beres, T.Tarkowski, P.Chen, D.Mani, S.2023-10-21doi:10.1101/2023.10.21.563410Cold Spring Harbor Laboratory Press2023-10-21
https://biorxiv.org/cgi/content/short/2023.10.22.563475v1?rss=1"
Ketaren, N. E.Fridy, P. C.Malashkevich, V.Sanyal, T.Brilliantes, M.Thompson, M. K.Orens, D. A.Bonanno, J. B.Sali, a.Almo, S. C.Chait, B. T.Rout, M. P.2023-10-22doi:10.1101/2023.10.22.563475Cold Spring Harbor Laboratory Press2023-10-22
https://biorxiv.org/cgi/content/short/2023.10.24.563841v1?rss=1"
Nuqui, X.Casalino, L.Zhou, L.Shehata, M.Wang, A.Tse, A. L.Ojha, A.Kearns, F. L.Rosenfeld, M. A.Miller, E. H.Acreman, C. M.Ahn, S.-H.Chandran, K.McLellan, J. S.Amaro, R. E.2023-10-25doi:10.1101/2023.10.24.563841Cold Spring Harbor Laboratory Press2023-10-25
https://biorxiv.org/cgi/content/short/2023.10.26.564164v1?rss=1"
Kumar, P.Tomita, T.Gerken, T. A.Ballard, C. J.Lee, Y. S.Weiss, L. M.Samara, N. L.2023-10-26doi:10.1101/2023.10.26.564164Cold Spring Harbor Laboratory Press2023-10-26
https://biorxiv.org/cgi/content/short/2023.10.24.563860v1?rss=1"
Cheung, B. C. H.Chen, X.Davis, H. J.Toth, J.Shenoy, V. B.Segall, J. E.Wu, M.2023-10-27doi:10.1101/2023.10.24.563860Cold Spring Harbor Laboratory Press2023-10-27
https://biorxiv.org/cgi/content/short/2023.10.27.564212v1?rss=1"
Genna, A.Alter, J.Poletti, M.Meirson, T.Sneh, T.Gendler, M.Saleev, N.Karagiannis, G.Wang, Y.Cox, D.Entenberg, D.Oktay, M.Korcsmaros, T.Condeelis, J.Gil-Henn, H.2023-10-29doi:10.1101/2023.10.27.564212Cold Spring Harbor Laboratory Press2023-10-29
https://biorxiv.org/cgi/content/short/2023.10.28.564559v1?rss=1"
Takeishi, S.Marchand, T.Koba, W. R.Borger, D. K.Xu, C.Guha, C.Bergman, A.Frenette, P. S.Gritsman, K.Steidl, U.2023-10-29doi:10.1101/2023.10.28.564559Cold Spring Harbor Laboratory Press2023-10-29
https://biorxiv.org/cgi/content/short/2023.10.30.564764v1?rss=1"
Li, X.Chen, H.Selvaraj, M. S.Van Buren, E.Zhou, H.Wang, Y.Sun, R.McCaw, Z. R.Yu, Z.Arnett, D. K.Bis, J. C.Blangero, J.Boerwinkle, E.Bowden, D. W.Brody, J. A.Cade, B. E.Carson, A. P.Carlson, J. C.Chami, N.Chen, Y.-D. I.Curran, J. E.de Vries, P. S.Fornage, M.Franceschini, N.Freedman, B. I.Gu, C.Heard-Costa, N. L.He, J.Hou, L.Hung, Y.-J.Irvin, M. R.Kaplan, R. C.Kardia, S. L. R.Kelly, T.Konigsberg, I.Kooperberg, C.Kral, B. G.Li, C.Loos, R. J. F.Mahaney, M. C.Martin, L. W.Mathias, R. A.Minster, R. L.Mitchell, B. D2023-11-02doi:10.1101/2023.10.30.564764Cold Spring Harbor Laboratory Press2023-11-02
https://biorxiv.org/cgi/content/short/2023.11.01.565151v1?rss=1"
Wang, J.Saul, J.Nikonorova, I. A.Cruz, C. N.Power, K. M.Nguyen, K. C.Hall, D. H.Barr, M. M.2023-11-03doi:10.1101/2023.11.01.565151Cold Spring Harbor Laboratory Press2023-11-03
https://biorxiv.org/cgi/content/short/2023.11.03.565494v1?rss=1"
JO, y.-h.Hwang, J.Okada, J.Liu, L.Pessin, J. E.Schwartz, G. J.2023-11-05doi:10.1101/2023.11.03.565494Cold Spring Harbor Laboratory Press2023-11-05
https://biorxiv.org/cgi/content/short/2023.11.06.565847v1?rss=1"
Caeiro, L.Nakata, Y.Borges, R. L.Garcia-Martinez, L.Banuelos, C.Stransky, S.Chan, H. L.Brabson, J.Dominguez, D.Zhang, Y.Lewis, P. W.Benitah, S. A.Cimmino, L.Bilbao, D.Sidoli, S.Verdun, R.Morey, L.2023-11-06doi:10.1101/2023.11.06.565847Cold Spring Harbor Laboratory Press2023-11-06
https://biorxiv.org/cgi/content/short/2023.11.06.565884v1?rss=1"
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org.highwire.dtl.DTLVardef@17086e6org.highwire.dtl.DTLVardef@a89f32org.highwire.dtl.DTLVardef@6baed5org.highwire.dtl.DTLVardef@1a32f80_HPS_FORMAT_FIGEXP M_FIG C_FIG Astrocyte endfoot responds to glymphatic shear stress when albumin is present. Mechanism involves sphingosine-1-phosphate (S1P) binding to its receptor (S1PR), activating phospholipase C (PLC) and thereby sensitizing the response of Piezo1 to flow. Ca2+ influx triggers Ca2+ release from intracellular stores and further downstream signaling, thereby modulating parenchymal perfusion. Illustration created using BioRender.com
]]>Ballesteros-Gomez, D.McCutcheon, S.Yang, G. L.Cibelli, A.Bispo, A.Krawchuk, M.Piedra, G.Spray, D. C.2023-11-07doi:10.1101/2023.11.06.565884Cold Spring Harbor Laboratory Press2023-11-07
https://biorxiv.org/cgi/content/short/2023.11.10.564562v1?rss=1"
O_LINKSMALLFIG WIDTH=185 HEIGHT=200 SRC="FIGDIR/small/564562v1_ufig2.gif" ALT="Figure 1">
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]]>Vaniya, A.Karlstaedt, A.Ates Gulkok, D.Thottakara, T.Liu, Y.Fan, S.Eades, H.Fukunaga, R.Vernon, H. J.Fiehn, O.Abraham, M. R.2023-11-15doi:10.1101/2023.11.10.564562Cold Spring Harbor Laboratory Press2023-11-15
https://biorxiv.org/cgi/content/short/2023.11.13.565361v1?rss=1"
Wang, G.Guasp, R.Salam, S.Chuang, E.Morera, A.Smart, A. J.Jimenez, D.Shekhar, S.Melentijevic, I.Nguyen, K. C.Hall, D. H.Grant, B. D.Driscoll, M.2023-11-16doi:10.1101/2023.11.13.565361Cold Spring Harbor Laboratory Press2023-11-16
https://biorxiv.org/cgi/content/short/2023.11.16.567340v1?rss=1"
Akella, J. S.Silva, M. S.Nguyen, K. C. Q.Hall, D. H.Barr, M. M.2023-11-17doi:10.1101/2023.11.16.567340Cold Spring Harbor Laboratory Press2023-11-17
https://biorxiv.org/cgi/content/short/2023.11.17.567618v1?rss=1"
Frankel, E. B.Tiroumalechetty, A. R.Henry, P. S.Su, Z.Wu, Y.Kurshan, P. T.2023-11-17doi:10.1101/2023.11.17.567618Cold Spring Harbor Laboratory Press2023-11-17
https://biorxiv.org/cgi/content/short/2023.11.19.566520v1?rss=1"
Hawkes, G.Beaumont, R. N.Li, Z.Mandla, R.Li, X.Albert, C. M.Arnett, D. K.Ashley-Koch, A. E.Ashrani, A. A.Barnes, K. C.Boerwinkle, E.Brody, J. A.Carson, A. P.Chami, N.Chen, Y.-D. I.Chung, M. K.Curran, J. E.Darbar, D.Ellinor, P. T.Fornage, M.Gordeuk, V. R.Guo, X.He, J.Hwu, C.-M.Kalyani, R. R.Kaplan, R.Kardia, S. L. R.Kooperberg, C.Loos, R. J. F.Lubitz, S. A.Minster, R. L.Mitchell, B. D.Murabito, J. M.Palmer, N. D.Psaty, B. M.Redline, S.Shoemaker, M. B.Silverman, E. K.Telen, M. J.Weiss, S. T.Yanek, L. R.Zhou, H.NH2023-11-20doi:10.1101/2023.11.19.566520Cold Spring Harbor Laboratory Press2023-11-20
https://biorxiv.org/cgi/content/short/2023.11.20.563492v1?rss=1"
Sabri, E.Batista-Brito, R.2023-11-21doi:10.1101/2023.11.20.563492Cold Spring Harbor Laboratory Press2023-11-21
https://biorxiv.org/cgi/content/short/2023.11.22.568065v1?rss=1"
Sun, S. H.Killian, N. J.Pezaris, J. S.2023-11-23doi:10.1101/2023.11.22.568065Cold Spring Harbor Laboratory Press2023-11-23
https://biorxiv.org/cgi/content/short/2023.11.30.569387v1?rss=1"
Sokolova, V.Miratsky, J.Svetlov, V.Brenowitz, M.Vant, J.Lewis, T. S.Dryden, K.Lee, G. L.Sarkar, S. L.Nudler, E.Singharoy, A.Tan, D.2023-11-30doi:10.1101/2023.11.30.569387Cold Spring Harbor Laboratory Press2023-11-30
https://biorxiv.org/cgi/content/short/2023.11.30.569417v1?rss=1"
de Magalhaes, C. G.Cvekl, A.Jaeger, R. G.Yan, C. Y. I.2023-12-01doi:10.1101/2023.11.30.569417Cold Spring Harbor Laboratory Press2023-12-01
https://biorxiv.org/cgi/content/short/2023.12.06.570390v1?rss=1"
Weiner, A. K.Radaoui, A. B.Tsang, M.Martinez, D.Sidoli, S.Conkrite, K. L.Delaidelli, A.Modi, A.Rokita, J. L.Patel, K.Lane, M. V.Zhang, B.Zhong, C.Ennis, B.Miller, D. P.Brown, M. A.Rathi, K. S.Raman, P.Pogoriler, J.Bhatti, T.Pawel, B.Glisovic-Aplenc, T.Teicher, B.Erickson, S. W.Earley, E. J.Bosse, K. R.Sorensen, P. H.Krytska, K.Mosse, Y. P.Havenith, K. E.Zammarchi, F.van Berkel, P. H.Smith, M. A.Garcia, B. A.Maris, J. M.Diskin, S. J.2023-12-08doi:10.1101/2023.12.06.570390Cold Spring Harbor Laboratory Press2023-12-08
https://biorxiv.org/cgi/content/short/2023.12.06.570397v1?rss=1"
Zhang, G.Su, Z.Zhang, T.Wu, Y.2023-12-08doi:10.1101/2023.12.06.570397Cold Spring Harbor Laboratory Press2023-12-08
https://biorxiv.org/cgi/content/short/2023.12.11.571163v1?rss=1"
Singh, S.Kanzin, D.Chavez, S.Saavedra-Avila, N. A.Ng, T.Lukos, R.Mayer, O.Kim, J.Chen, B.Chen, M.Porcelli, S.Jacobs, W. R.Tiwari, S.2023-12-12doi:10.1101/2023.12.11.571163Cold Spring Harbor Laboratory Press2023-12-12
https://biorxiv.org/cgi/content/short/2023.12.12.571293v1?rss=1"
Clayton, J.Romany, A.Matenoglou, E.Gavathiotis, E.Poulikakos, P. I.Shen, J.2023-12-12doi:10.1101/2023.12.12.571293Cold Spring Harbor Laboratory Press2023-12-12
https://biorxiv.org/cgi/content/short/2023.12.12.571310v1?rss=1"
Moir, R. D.Merheb, E.Chitu, V.Stanley, E. R.Willis, I. M.2023-12-12doi:10.1101/2023.12.12.571310Cold Spring Harbor Laboratory Press2023-12-12
https://biorxiv.org/cgi/content/short/2023.12.14.571774v1?rss=1"
O'Leary, K.Zheng, D.2023-12-15doi:10.1101/2023.12.14.571774Cold Spring Harbor Laboratory Press2023-12-15
https://biorxiv.org/cgi/content/short/2023.12.15.571088v1?rss=1"
Aldous, S. G.Smith, E. J.Landles, C.Osborne, G. F.Canibano-Pico, M.Nita, I. M.Phillips, J.Zhang, Y.Jin, B.Hirst, M. B.Benn, C. L.Bond, B. C.Edelmann, W.Greene, J. R.Bates, G. P.2023-12-15doi:10.1101/2023.12.15.571088Cold Spring Harbor Laboratory Press2023-12-15
https://biorxiv.org/cgi/content/short/2023.12.15.571909v1?rss=1"
Luo, Q.Raulston, E. G.Prado, M. A.Wu, X.Gritsman, K.Booth, C. A. G.Xu, R.van Galen, P.Doench, J. G.Shimony, S.Long, H. W.Neuberg, D. S.Paulo, J. A.Lane, A. A.2023-12-15doi:10.1101/2023.12.15.571909Cold Spring Harbor Laboratory Press2023-12-15
https://biorxiv.org/cgi/content/short/2023.12.15.571760v1?rss=1"
Ealo, T.Sanchez-Gaya, V.Respuela, P.Munoz-San Martin, M.Martin-Batista, E.Haro, E.Rada-Iglesias, A.2023-12-16doi:10.1101/2023.12.15.571760Cold Spring Harbor Laboratory Press2023-12-16
https://biorxiv.org/cgi/content/short/2023.12.27.573459v1?rss=1"
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]]>Seah, C.Singer, R.Deans, P. M.Bader, H.Rusielewicz, T.Hicks, E. M.Young, H.Cote, A.Townsley, K.Xu, C.Hunter, C. J.McCarthy, B.Goldberg, J.Dobariya, S.Holtzherimer, P. E.Young, K. A.NYSCF Global Stem Cell Array Team,Traumatic Stress Brain Research Group,Noggle, S. A.Krystal, J. H.Paull, D.Girgenti, M. J.Yehuda, R.Brennand, K.Huckins, L.2023-12-28doi:10.1101/2023.12.27.573459Cold Spring Harbor Laboratory Press2023-12-28
https://biorxiv.org/cgi/content/short/2023.12.28.573568v1?rss=1"
Reyes-Gopar, H.Marston, J. L.Singh, B.Greenig, M.Lin, J.Ostrowski, M. A.Randall, K. N.Sandoval-Motta, S.Dopkins, N.Lawrence, E.O'Mara, M. M.Fei, T.Duarte, R. R. R.Powell, T. R.Hernandez-Lemus, E.Iniguez, L. P.Nixon, D. F.Bendall, M. L.2023-12-28doi:10.1101/2023.12.28.573568Cold Spring Harbor Laboratory Press2023-12-28
https://biorxiv.org/cgi/content/short/2024.01.14.575609v1?rss=1"
Horisberger, A.Griffith, A.Keegan, J.Arazi, A.Pulford, J.Murzin, E.Howard, K.Hancock, B.Fava, A.Sasaki, T.Ghosh, T.Inamo, J.Beuschel, R.Cao, Y.Preisinger, K.Gutierrez-Arcelus, M.Eisenhaure, T. M.Guthridge, J.Hoover, P. J.Dall'Era, M.Wofsy, D.Kamen, D. L.Kalunian, K. C.Furie, R.Belmont, M.Izmirly, P.Clancy, R.Hildeman, D.Woodle, E. S.Apruzzese, W.McMahon, M. A.Grossman, J.Barnas, J. L.Payan-Schober, F.Ishimori, M.Weisman, M.Kretzler, M.Berthier, C. C.Hodgin, J. B.Demeke, D. S.Putterman, C.Accelerating Medicines Pa2024-01-16doi:10.1101/2024.01.14.575609Cold Spring Harbor Laboratory Press2024-01-16
https://biorxiv.org/cgi/content/short/2024.01.23.576931v1?rss=1"
Rojas, R.Grinan-Ferre, C.Castellanos, A.Griego, E.Martinez, M.Navarro-Lopez, J. d. D.Jimenez-Diaz, L.Rodriguez-Alvarez, J.Soto del Cerro, D.Castillo, P. E.Pallas, M.Fado, R.Casals, N.2024-01-24doi:10.1101/2024.01.23.576931Cold Spring Harbor Laboratory Press2024-01-24
https://biorxiv.org/cgi/content/short/2024.01.24.577010v1?rss=1"
Catala Solsona, J.Lutzu, S.Lituma, P. J.Fabregas Ordonez, C.Siedlecki, D.Gimenez-Llort, L.Minano-Molina, A. J.Saura, C. A.Castillo, P. E.Rodriguez Alvarez, J.2024-01-24doi:10.1101/2024.01.24.577010Cold Spring Harbor Laboratory Press2024-01-24
https://biorxiv.org/cgi/content/short/2024.02.01.578272v1?rss=1"
Cheng, Y.Cai, B.Li, H.Zhang, X.D'Souza, G.Shrestha, S.Edmonds, A.Meyers, J.Fischl, M.Kassaye, S.Anastos, K.Cohen, M.Aouizerat, B. E.Xu, K.Zhao, H.2024-02-02doi:10.1101/2024.02.01.578272Cold Spring Harbor Laboratory Press2024-02-02
https://biorxiv.org/cgi/content/short/2024.02.06.578742v1?rss=1"
Uboveja, A.Huang, Z.Buj, R.Amalric, A.Wang, H.Tangudu, N. K.Cole, A. R.Megill, E.Kantner, D.Chatoff, A.Ahmad, H.Marcinkiewicz, M. M.Disharoon, J. A.Graff, S.Dahl, E. S.Hempel, N.Stallaert, W.Sidoli, S.Bitler, B. G.Long, D. T.Snyder, N. W.Aird, K. M.2024-02-07doi:10.1101/2024.02.06.578742Cold Spring Harbor Laboratory Press2024-02-07
https://biorxiv.org/cgi/content/short/2024.02.12.579917v1?rss=1"
G+FS, SYNJ1 R258Q/FS, VPS13C A444P, VPS13C W395C, GBA1 IVS2+1). All mutations were generated in a fully characterized and sequenced female human embryonic stem cell (hESC) line (WIBR3; NIH approval number NIHhESC-10-0079) using CRISPR/Cas9 or prime editing-based approaches. We implemented rigorous quality controls, including high density genotyping to detect structural variants and confirm the genomic integrity of each cell line. This systematic approach ensures the high quality of our stem cell collection, highlights differences between conventional CRISPR/Cas9 and prime editing and provides a roadmap for how to generate gene-edited hPSCs collections at scale in an academic setting. We expect that our isogenic stem cell collection will become an accessible platform for the study of PD, which can be used by investigators to understand the molecular pathophysiology of PD in a human cellular setting.
]]>Busquets, O.Li, H.Syed, K. M.Jerez, P. A.Dunnack, J.Bu, R. L.Verma, Y.Pangilinan, G. R.Martin, A.Straub, J.Du, Y.Simon, V. M.Poser, S.Bush, Z.Diaz, J.Sahagun, A.Gao, J.Hernandez, D.Levine, K. S.Booth, E. O.Bateup, H.Rio, D.Hockemeyer, D.Blauwendraat, C.Soldner, F.2024-02-13doi:10.1101/2024.02.12.579917Cold Spring Harbor Laboratory Press2024-02-13
https://biorxiv.org/cgi/content/short/2024.02.19.581109v1?rss=1"
Griego, E.Cerna, C.Sollozo-Dupont, I.Fuenzalida, M.Galvan, E. J.2024-02-22doi:10.1101/2024.02.19.581109Cold Spring Harbor Laboratory Press2024-02-22
https://biorxiv.org/cgi/content/short/2024.02.20.581228v1?rss=1"
JO, y.-h.Hwang, J.jo, W.Chua, S.Schwartz, G. J.2024-02-23doi:10.1101/2024.02.20.581228Cold Spring Harbor Laboratory Press2024-02-23
https://biorxiv.org/cgi/content/short/2024.02.21.581451v1?rss=1"
Bonifazi, A.Ellenberger, M.Farino, Z. J.Aslanoglou, D.Rais, R.Pereira, S.Mantilla-Rivas, J. O.Boateng, C. A.Eshleman, A. J.Janowsky, A.Hahn, M. K.Schwartz, G. J.Slusher, B. S.Freyberg, Z.2024-02-23doi:10.1101/2024.02.21.581451Cold Spring Harbor Laboratory Press2024-02-23
https://biorxiv.org/cgi/content/short/2024.03.02.583110v1?rss=1"
Shin, O. S.Monticelli, S. R.Hjorth, C. K.Hornet, V.Doyle, M.Abelson, D.Kuehne, A. I.Wang, A.Bakken, R. R.Mishra, A. K.Middlecamp, M.Champney, E.Stuart, L.Maurer, D. P.Li, J.Berrigan, J. L.Balinandi, S.Lutwama, J. J.Lobel, L.Zeitlin, L.Walker, L. M.Dye, J. M.Chandran, K.Herbert, A. S.Pauli, N. T.McLellan, J. S.2024-03-06doi:10.1101/2024.03.02.583110Cold Spring Harbor Laboratory Press2024-03-06
https://biorxiv.org/cgi/content/short/2024.03.04.583378v1?rss=1"
Kim, J.Yuan, Y.Agaronyan, K.Zhao, A.Wang, V. D.Gupta, G.Essayas, H.Kaminski, A.McGovern, J.Yu, S.Woo, S.Lee, C. J.Saleh, T.Hu, B.Sun, Y.Ishikawa, G.Bain, W.Evankovich, J.Herzog, E.Dela Cruz, C. S.Ryu, C.Sharma, L.2024-03-06doi:10.1101/2024.03.04.583378Cold Spring Harbor Laboratory Press2024-03-06
https://biorxiv.org/cgi/content/short/2024.03.05.583565v1?rss=1"
View larger version (24K):
org.highwire.dtl.DTLVardef@146da24org.highwire.dtl.DTLVardef@9ba25aorg.highwire.dtl.DTLVardef@1bfd57corg.highwire.dtl.DTLVardef@158f414_HPS_FORMAT_FIGEXP M_FIG UM cells disseminate to the liver and stay dormant for a prolonged period before manifesting as overt metastasis(A). Dormant UM DCCs express high levels of NR2F1 which induces transcriptional repression of YAP1 by binding to its promoter (B). Binding of NR2F1 inhibits recruitment of H3K4me3 and H3K27ac gene activation marks onto YAP1 promoter and globally represses programs related to cell cycle proliferation, transcriptional initiation and GPCR signaling while activating axonal guidance and neural crest migration pathways in dormant UM DCCs (B). With time, dormant UM DCCs lose NR2F1 expression (C) and are reawakened to give rise to overt metastasis as NR2F1 binding onto the YAP promoter is reduced leading to activation of YAP1 oncogenic signaling (C). Also, YAP1 inhibits NR2F1 expression through unknown mechanisms causing activation of cell cycle proliferation, transcriptional initiation and GPCR pathways and inhibition of neuronal programs (C).
C_FIG
]]>Kadamb, R.Anton, M. L.Purwin, T. J.Chua, V.Seeneevassen, L.Teh, J.Nieto, M. A.Sato, T.Terai, M.Roman, S.de Koning, L.Zheng, D.Aplin, A. E.Aguirre-Ghiso, J.2024-03-08doi:10.1101/2024.03.05.583565Cold Spring Harbor Laboratory Press2024-03-08
https://biorxiv.org/cgi/content/short/2024.03.08.584145v1?rss=1"
Emmons, S. W.2024-03-13doi:10.1101/2024.03.08.584145Cold Spring Harbor Laboratory Press2024-03-13
https://biorxiv.org/cgi/content/short/2024.03.11.584509v1?rss=1"
Lagou, M. K.Argyris, D. G.Vodopyanov, S.Gunther-Cummins, L.Hardas, A.Poutahidis, T.Panorias, C.DesMarais, S.Entenberg, C.Carpenter, R. S.Guzik, H.Nishku, X.Churaman, J.Maryanovich, M.DesMarais, V.Macaluso, F. P.Karagiannis, G. S.2024-03-14doi:10.1101/2024.03.11.584509Cold Spring Harbor Laboratory Press2024-03-14
https://biorxiv.org/cgi/content/short/2024.03.12.584656v1?rss=1"
Hassan, O.Pizzagalli, M.Wu, L. J.Karambizi, D.Zepecki, J. P.Fajardo, E.Fiser, A.Tapinos, N.2024-03-14doi:10.1101/2024.03.12.584656Cold Spring Harbor Laboratory Press2024-03-14
https://biorxiv.org/cgi/content/short/2024.03.12.584663v1?rss=1"
Dowrey, T. W.Cranston, S. F.Skvir, N.Lok, Y.Gould, B.Petrowitz, B.Villar, D.Shan, J.James, M.Dodge, M.Belkina, A. C.Giadone, R. M.Sebastiani, P.Perls, T. T.Andersen, S. L.Murphy, G. J.2024-03-14doi:10.1101/2024.03.12.584663Cold Spring Harbor Laboratory Press2024-03-14
https://biorxiv.org/cgi/content/short/2024.03.14.584861v1?rss=1"
ALQAZZAZ, M.Ciamponi, F. E.Ho, J. C.Maron, M. I.Yadav, M.Sababi, A. M.Macleod, G.Ahmadi, M.Bullivant, G.Tano, V.Langley, S. R.Osuna, M. S.Sachamitr, P.Kushida, M.Richards, L. M.Bardile, C. F.Pouladi, M.Pugh, T.Tyers, M.Angers, S.Dirks, P. B.Bader, G.Massirer, K. B.Barsyte-Lovejoy, D.Shechter, D.Harding, R. J.Arrowsmith, C.Prinos, P.2024-03-14doi:10.1101/2024.03.14.584861Cold Spring Harbor Laboratory Press2024-03-14
https://biorxiv.org/cgi/content/short/2024.03.18.585626v1?rss=1"
Ding, K.Chen, L.Levine, K. M.Sikora, M. J.Tasdemir, N.Dabbs, D.Jankowitz, R.Hazan, R. S.Shah, O. S.Xavier, J. M.LEE, A. V.Oesterreich, S.2024-03-20doi:10.1101/2024.03.18.585626Cold Spring Harbor Laboratory Press2024-03-20
https://biorxiv.org/cgi/content/short/2024.03.20.585881v1?rss=1"
Salloum, S.Seveno, M.El-koulali, K.Rialle, S.George, S.Lemmers, B.Zibara, K.Eliscovich, C.Hahne, M.Bertrand, E.2024-03-20doi:10.1101/2024.03.20.585881Cold Spring Harbor Laboratory Press2024-03-20