bioRxiv Channel: University of Iowa https://biorxiv.org This feed contains articles for bioRxiv Channel "University of Iowa" bioRxiv bioRxiv https://biorxiv.org <![CDATA[ Identification of Iron-Sulfur (Fe-S) and Zn-binding Sites Within Proteomes Predicted by DeepMind's AlphaFold2 Program Dramatically Expands the Metalloproteome ]]> https://biorxiv.org/content/10.1101/2021.10.08.463726v1?rss=1 360,000 structures made available for download. Here we show that thousands of novel binding sites for iron-sulfur (Fe-S) clusters and zinc ions can be identified within these predicted structures by exhaustive enumeration of all potential ligand-binding orientations. We demonstrate that AlphaFold2 routinely makes highly specific predictions of ligand binding sites: for example, binding sites that are comprised exclusively of four cysteine sidechains fall into three clusters, representing binding sites for 4Fe-4S clusters, 2Fe-2S clusters, or individual Zn ions. We show further: (a) that the majority of known Fe-S cluster and Zn-binding sites documented in UniProt are recovered by the AlphaFold2 structures, (b) that there are occasional disputes between AlphaFold2 and UniProt with AlphaFold2 predicting highly plausible alternative binding sites, (c) that the Fe-S cluster binding sites that we identify in E. coli agree well with previous bioinformatics predictions, (d) that cysteines predicted here to be part of Fe-S cluster or Zn-binding sites show little overlap with those shown via chemoproteomics techniques to be highly reactive, and (e) that AlphaFold2 occasionally appears to build erroneous disulfide bonds between cysteines that should instead coordinate a ligand. These results suggest that AlphaFold2 could be an important tool for the functional annotation of proteomes, and the methodology presented here is likely to be useful for predicting other ligand-binding sites. ]]> Wehrspan, Z. J. McDonnell, R. T. Elcock, A. 2021-10-09 doi:10.1101/2021.10.08.463726 Cold Spring Harbor Laboratory Press 2021-10-09 <![CDATA[ Background selection as baseline for nucleotide variation across the Drosophila genome ]]> https://biorxiv.org/content/10.1101/005017v1?rss=1 Josep M Comeron 2014-05-09 doi:10.1101/005017 Cold Spring Harbor Laboratory Press 2014-05-09 <![CDATA[ Bayesian analyses of Yemeni mitochondrial genomes suggest multiple migration events with Africa and Western Eurasia ]]> https://biorxiv.org/content/10.1101/010629v1?rss=1 Deven Nikunj Vyas Andrew Kitchen Aida Teresa Miró-Herrans Laurel Nichole Pearson Ali Al-Meeri Connie Jo Mulligan 2014-10-23 doi:10.1101/010629 Cold Spring Harbor Laboratory Press 2014-10-23 <![CDATA[ The Nature, Extent, and Consequences of Cryptic Genetic Variation in the opa Repeats of Notch in Drosophila ]]> https://biorxiv.org/content/10.1101/020529v1?rss=1 40 residues are pathologically prone to amyloidogenic self-assembly. Here, we assess the extent and consequences of variation in the pQ-encoding opa repeats of Notch (N) in Drosophila melanogaster. We use Sanger sequencing to genotype opa sequences (5-CAX repeats), which have resisted assembly using short sequence reads. While the majority of N sequences pertain to reference opa31 (Q13HQ17) and opa32 (Q13HQ18) allelic classes, several rare alleles encode tracts > 32 residues: opa33a (Q14HQ18), opa33b (Q15HQ17), opa34 (Q16HQ17), opa35a1/opa35a2 (Q13HQ21), opa36 (Q13HQ22), and opa37 (Q13HQ23). Only one rare allele encodes a tract < 31 residues: opa23 (Q13-Q10). This opa23 allele shortens the pQ tract while simultaneously eliminating the interrupting histidine. Homozygotes for the short and long opa alleles have defects in sensory bristle organ specification, abdominal patterning, and embryonic survival. Inbred stocks with wild-type opa31 alleles become more viable when outbred, while an inbred stock with the longer opa35 becomes less viable after outcrossing to different backgrounds. In contrast, an inbred stock with the short opa23 allele is semi-viable in both inbred and outbred genetic backgrounds. This opa23 Notch allele also produces notched wings when recombined out of the X chromosome. Importantly, wa-linked X balancers carry the N allele opa33b and suppress AS-C insufficiency caused by the sc8 inversion. Our results demonstrate significant cryptic variation and epistatic sensitivity for the N locus, and the need for long read genotyping of key repeat variables underlying gene regulatory networks. ]]> Clinton Rice Danielle Beekman Liping Liu Albert Erives 2015-06-07 doi:10.1101/020529 Cold Spring Harbor Laboratory Press 2015-06-07 <![CDATA[ The Nature, Extent, and Consequences of Genetic Variation in the opa Repeats of Notch in Drosophila ]]> https://biorxiv.org/content/10.1101/020826v1?rss=1 40 residues are pathologically prone to amyloidogenic self-assembly. Here, we assess the extent and consequences of variation in the pQ-encoding opa repeats of Notch (N) in Drosophila melanogaster. We use Sanger sequencing to genotype opa sequences (50-CAX repeats), which have resisted assembly using short sequence reads. While the majority of N sequences pertain to reference opa31 (Q13HQ17) and opa32 (Q13HQ18) allelic classes, several rare alleles encode tracts > 32 residues: opa33a (Q14HQ18), opa33b (Q15HQ17), opa34 (Q16HQ17), opa35a1/opa35a2 (Q13HQ21), opa36 (Q13HQ22), and opa37 (Q13HQ23). Only one rare allele encodes a tract < 31 residues: opa23 (Q13-Q10). This opa23 allele shortens the pQ tract while simultaneously eliminating the interrupting histidine. Homozygotes for the short and long opa alleles have defects in sensory bristle organ specification, abdominal patterning, and embryonic survival. Inbred stocks with wild-type opa31 alleles become more viable when outbred, while an inbred stock with the longer opa35 becomes less viable after outcrossing to different backgrounds. In contrast, an inbred stock with the short opa23 allele is semi-viable in both inbred and outbred genetic backgrounds. This opa23 Notch allele also produces notched wings when recombined out of the X chromosome. Importantly, wa-linked X balancers carry the N allele opa33b and suppress AS-C insufficiency caused by the sc8 inversion. Our results demonstrate potent pQ variation and epistatic sensitivity for the N locus, and the need for long read genotyping of key repeat variables underlying gene regulatory networks. ]]> Clinton Rice Danielle Beekman Liping Liu Albert J Erives 2015-06-12 doi:10.1101/020826 Cold Spring Harbor Laboratory Press 2015-06-12 <![CDATA[ Eukaryotic core histone diversification in light of the histone doublet and DNA topo II genes of Marseilleviridae ]]> https://biorxiv.org/content/10.1101/022236v1?rss=1 Albert J Erives 2015-07-08 doi:10.1101/022236 Cold Spring Harbor Laboratory Press 2015-07-08 <![CDATA[ Impact of the X chromosome and sex on regulatory variation ]]> https://biorxiv.org/content/10.1101/024117v1?rss=1 Kimberly R Kukurba Princy Parsana Kevin S Smith Zachary Zappala David A Knowles Marie-Julie Favé Xin Li Xiaowei Zhu James B Potash Myrna M Weissman Jianxin Shi Anshul Kundaje Douglas F Levinson Philip Awadalla Sara Mostafavi Alexis Battle Stephen B Montgomery 2015-08-07 doi:10.1101/024117 Cold Spring Harbor Laboratory Press 2015-08-07 <![CDATA[ Allele-specific expression reveals interactions between genetic variation and environment ]]> https://biorxiv.org/content/10.1101/025874v1?rss=1 David A Knowles Joe R Davis Anil Raj Xiaowei Zhu James B Potash Myrna M Weissman Jianxin Shi Douglas F Levinson Sara Mostafavi Stephen B Montgomery Alexis Battle 2015-09-01 doi:10.1101/025874 Cold Spring Harbor Laboratory Press 2015-09-01 <![CDATA[ Maternal genome-wide association study identifies a fasting glucose variant associated with offspring birth weight ]]> https://biorxiv.org/content/10.1101/034207v1?rss=1 Bjarke Feenstra Alana Cavadino Jessica Tyrrell George McMahon Michael Nodzenski Momoko Horikoshi Frank Geller Ronny Myhre Rebecca Richmond Lavinia Paternoster Jonathan Bradfield Eskil Kreiner-Moller Ville Huikari Sarah Metrustry Kathryn Lunetta Jodie Painter Jouke-Jan Hottenga Catherine Allard Sheila Barton Ana Espinosa Julie Marsh Catherine Potter Wei Ang Diane Berry Luigi Bouchard Shikta Das Hakon Hakonarson Jani Heikkinen Berthold Hocher Albert Hofman Hazel Inskip Manolis Kogevinas Penelope Lind Letizia Marullo Sarah Medland Jeffrey Murray Ellen Nohr Christoph Reichetzeder Susan Ring Loreto 2015-12-11 doi:10.1101/034207 Cold Spring Harbor Laboratory Press 2015-12-11 <![CDATA[ The genomic basis of electrotaxis in Dictyostelium discoideum: Electric field sensitive amino acids are dynamically encoded en masse for the streaming-stage proteome ]]> https://biorxiv.org/content/10.1101/034892v1?rss=1 Albert J Erives 2015-12-20 doi:10.1101/034892 Cold Spring Harbor Laboratory Press 2015-12-20 <![CDATA[ A Notch and Su(H) dependent enhancer complex coordinates expression of nab in Drosophila ]]> https://biorxiv.org/content/10.1101/036038v1?rss=1 Elizabeth Stroebele Albert Erives 2016-01-06 doi:10.1101/036038 Cold Spring Harbor Laboratory Press 2016-01-06 <![CDATA[ Intracranial Markers of Conscious Face Perception in Humans ]]> https://biorxiv.org/content/10.1101/037234v1?rss=1 Fabiano Baroni Jochem van Kempen Hiroto Kawasaki Christopher K. Kovach Hiroyuki Oya Matthew A. Howard Ralph Adolphs Naotsugu Tsuchiya 2016-02-01 doi:10.1101/037234 Cold Spring Harbor Laboratory Press 2016-02-01 <![CDATA[ Contents of Consciousness Investigated as Integrated Information in Direct Human Brain Recordings ]]> https://biorxiv.org/content/10.1101/039032v1?rss=1 Andrew M. Haun Masafumi Oizumi Christopher K Kovach Hiroto Kawasaki Hiroyuki Oya Matthew A Howard Ralph Adolphs Naotsugu Tsuchiya 2016-02-15 doi:10.1101/039032 Cold Spring Harbor Laboratory Press 2016-02-15 <![CDATA[ A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects ]]> https://biorxiv.org/content/10.1101/040493v1?rss=1 Christian Marshall Daniel Howrigan Daniele Merico Bhooma Thiruvahindrapuram Wenting Wu Douglas Greer Daniel Antaki Aniket Shetty Peter Holmans Dalila Pinto Madhusudan Gujral William Brandler Dheeraj Malholtra Zhouzhi Wang Karin Fuentes Fajarado Stephan Ripke Ingrid Agartz Esben Agerbo Margot Albus Madeline Alexander Farooq Amin Joshua Atkins Silviu Bacanu Richard Belliveau Sarah Bergen Marcelo Bertalan Elizabeth Bevilacqua Tim Bigdeli Donald Black Richard Bruggeman Nancy Buccola Randy Buckner Brendan Bulik-Sullivan William Byerley Wiepke Cahn Guiqing Cai Murray Cairns Dominique Campion Rita Ca 2016-02-23 doi:10.1101/040493 Cold Spring Harbor Laboratory Press 2016-02-23 <![CDATA[ Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder ]]> https://biorxiv.org/content/10.1101/044412v1?rss=1 9 million genetic variants in 9,784 bipolar disorder patients and 30,471 controls, the largest GWAS of BD to date. In this study, to increase power we used ~2,000 lithium-treated cases with a long-term diagnosis of BD from the Consortium on Lithium Genetics, excess controls, and analytic methods optimized for markers on the X-chromosome. In addition to four known loci, results revealed genome-wide significant associations at two novel loci: an intergenic region on 9p21.3 (rs12553324, p = 5.87x10-9; odds ratio = 1.12) and markers within ERBB2 (rs2517959, p = 4.53x10-9; odds ratio = 1.13). No significant X-chromosome associations were detected and X-linked markers explained very little BD heritability. The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS. ]]> Liping Hou Sarah E Bergen Nirmala Akula Jie Song Christina M Hultman Mikael Landen Mazda Adli Martin Alda Raffaella Ardau Barbara Arias Jean-Michel Aubry Lena Backlund Judith A Badner Thomas B Barrett Michael Bauer Bernhard T Baune Frank Bellivier Antonio Benabarre Susanne Bengesser Wade H Berrettini Abesh Kumar Bhattacharjee Joanna M Biernacka Armin Birner Cinnamon S Bloss Clara Brichant-Petitjean Elise T Bui William Byerley Pablo Cervantes Caterina Chillotti Sven Cichon Francesc Colom William Coryell David W Craig Cristiana Cruceanu Piotr M Czerski Tony Davis Alexandre Dayer Franziska Degenh 2016-03-22 doi:10.1101/044412 Cold Spring Harbor Laboratory Press 2016-03-22 <![CDATA[ Genomic evidence for population-specific responses to coevolving parasites in a New Zealand freshwater snail ]]> https://biorxiv.org/content/10.1101/045674v1?rss=1 Laura Bankers Peter Fields Kyle E. McElroy Jeffrey Boore John M. Logsdon Maurine Neiman 2016-03-25 doi:10.1101/045674 Cold Spring Harbor Laboratory Press 2016-03-25 <![CDATA[ Radical changes persist longer in the absence of sex ]]> https://biorxiv.org/content/10.1101/049924v1?rss=1 Joel Sharbrough Meagan Luse Jeffrey L Boore John M Logsdon Maurine Neiman 2016-04-23 doi:10.1101/049924 Cold Spring Harbor Laboratory Press 2016-04-23 <![CDATA[ Male density and rapid evolution of genital morphology in the seed beetle Callosobruchus maculatus ]]> https://biorxiv.org/content/10.1101/052332v1?rss=1 Deanna Soper Willow Macy 2016-05-10 doi:10.1101/052332 Cold Spring Harbor Laboratory Press 2016-05-10 <![CDATA[ Goggatomy: a Method for Opening Small Cuticular Compartments in Arthropods for Physiological Experiments ]]> https://biorxiv.org/content/10.1101/053298v1?rss=1 Alan R Kay Davide Raccuglia Jon Scholte Elena Loukianova Christopher A Barwacz Steven A Armstrong C Allan Guymon Michael N Nitabach Daniel F Eberl 2016-05-18 doi:10.1101/053298 Cold Spring Harbor Laboratory Press 2016-05-18 <![CDATA[ Genomic dimensions of Su(H)-targeted regulatory belts in Drosophila ]]> https://biorxiv.org/content/10.1101/055707v1?rss=1 Elizabeth Stroebele Timothy Fuqua Madelyn Warren Danielle Herrig Christian Noblett Xin Yuan Albert Erives 2016-05-27 doi:10.1101/055707 Cold Spring Harbor Laboratory Press 2016-05-27 <![CDATA[ A Rationally Designed Aminoacyl-tRNA Synthetase for Genetically Encoded Fluorescent Amino Acids ]]> https://biorxiv.org/content/10.1101/065227v1?rss=1 Ximena Steinberg Jason Galpin Gibran Nasir Jose Sepulveda-Ugarte Romina Sepulveda Fernando Gonzalez-Nilo Leon D Islas Christopher A Ahern Sebastian E Brauchi 2016-07-22 doi:10.1101/065227 Cold Spring Harbor Laboratory Press 2016-07-22 <![CDATA[ Experimental Reconstitution of Chronic ER Stress in the Liver Reveals Feedback Suppression of Bip mRNA Expression ]]> https://biorxiv.org/content/10.1101/067744v1?rss=1 Javier A. Gomez D. Thomas Rutkowski 2016-08-04 doi:10.1101/067744 Cold Spring Harbor Laboratory Press 2016-08-04 <![CDATA[ Cotranslational assembly imposes evolutionary constraints on homomeric proteins ]]> https://biorxiv.org/content/10.1101/074963v1?rss=1 Eviatar Natan Tamaki Endoh Liora Haim-Vilmovsky Guilhem Chalancon Tilman Flock Jonathan TS Hopper Balint Kintses Lejla Daruka Gergely Fekete Csaba Pal Balazs Papp Peter Horvath Joseph A Marsh Adrian H Elcock M Madan Babu Carol V Robinson Naoki Sugimoto Sarah A Teichmann 2016-09-13 doi:10.1101/074963 Cold Spring Harbor Laboratory Press 2016-09-13 <![CDATA[ PyVar: An Extensible Framework for Variant Annotator Comparison ]]> https://biorxiv.org/content/10.1101/078386v1?rss=1 Julie Wertz Thomas B Bair Michael S Chimenti 2016-09-30 doi:10.1101/078386 Cold Spring Harbor Laboratory Press 2016-09-30 <![CDATA[ Evolving Notch polyQ tracts reveal possible solenoid interference elements ]]> https://biorxiv.org/content/10.1101/079038v1?rss=1 Albert J Erives 2016-10-03 doi:10.1101/079038 Cold Spring Harbor Laboratory Press 2016-10-03 <![CDATA[ CMPyMOL: A Tool for Protein Contact-Map Analysis ]]> https://biorxiv.org/content/10.1101/084269v1?rss=1 Krishnamani, V. 2016-10-28 doi:10.1101/084269 Cold Spring Harbor Laboratory Press 2016-10-28 <![CDATA[ De novo transcriptome characterization of a sterilizing trematode parasite (Microphallus sp.) from two species of New Zealand snails ]]> https://biorxiv.org/content/10.1101/086801v1?rss=1 Bankers, L. Neiman, M. 2016-11-09 doi:10.1101/086801 Cold Spring Harbor Laboratory Press 2016-11-09 <![CDATA[ Genetic variation for mitochondrial function in the New Zealand freshwater snail Potamopyrgus antipodarum ]]> https://biorxiv.org/content/10.1101/087155v1?rss=1 Sharbrough, J. Cruise, J. L. Beetch, M. Enright, N. M. Neiman, M. 2016-11-11 doi:10.1101/087155 Cold Spring Harbor Laboratory Press 2016-11-11 <![CDATA[ Systematic integration of biomedical knowledge prioritizes drugs for repurposing ]]> https://biorxiv.org/content/10.1101/087619v1?rss=1 Himmelstein, D. S. Lizee, A. Hessler, C. Brueggeman, L. Chen, S. L. Hadley, D. Green, A. Khankhanian, P. Baranzini, S. E. 2016-11-14 doi:10.1101/087619 Cold Spring Harbor Laboratory Press 2016-11-14 <![CDATA[ Engineered tRNA suppression of a CFTR nonsense mutation ]]> https://biorxiv.org/content/10.1101/088690v1?rss=1 Lueck, J. D. Infield, D. T. Mackey, A. L. Pope, M. R. McCray, P. B. Ahern, C. A. 2016-11-20 doi:10.1101/088690 Cold Spring Harbor Laboratory Press 2016-11-20 <![CDATA[ Multichannel Sleep Spindle Detection Using Sparse Low-Rank Optimization ]]> https://biorxiv.org/content/10.1101/104414v1?rss=1 Parekh, A. Selesnick, I. Osorio, R. S. Varga, A. W. Rapoport, D. M. Ayappa, I. 2017-04-10 doi:10.1101/104414 Cold Spring Harbor Laboratory Press 2017-04-10 <![CDATA[ Conserved properties of Drosophila Insomniac link sleep regulation and synaptic function ]]> https://biorxiv.org/content/10.1101/104893v1?rss=1 Li, Q. Kellner, D. A. Hatch, H. A. M. Yumita, T. Sanchez, S. Machold, R. P. Frank, C. A. Stavropoulos, N. 2017-02-01 doi:10.1101/104893 Cold Spring Harbor Laboratory Press 2017-02-01 <![CDATA[ The maternal genetic make-up of the Iberian Peninsula between the Neolithic and the Early Bronze Age ]]> https://biorxiv.org/content/10.1101/106963v1?rss=1 Szecsenyi-Nagy, A. Roth, C. Guido, B. Rihuete-Herrada, C. Tejedor-Rodriguez, C. Held, P. Garcia-Martinez-de-Lagran, I. Arcusa Magallon, H. Zesch, S. Knipper, C. Banffy, E. Friedrich, S. Meller, H. Bueno-Ramirez, P. Barroso Bermejo, R. de Balbin Behrmann, R. Herrero-Coral, A. M. Flores Fernandez, R. Alonso Fernandez, C. Jimenez Echevarria, J. Rindlisbacher, L. Oliart, C. Fregeiro, M.-I. Soriano, I. Vincente, O. Mico, R. Lull, V. Soler Diaz, J. Lopez Padilla, J. A. Roca de Togores Munoz, C. Hernandez Perez, M. S. Jover Maestre, F. J. Lomba Maurandi, J. Aviles Fer 2017-02-10 doi:10.1101/106963 Cold Spring Harbor Laboratory Press 2017-02-10 <![CDATA[ Dystroglycan Maintains Inner Limiting Membrane Integrity To Coordinate Retinal Development ]]> https://biorxiv.org/content/10.1101/121756v1?rss=1 Clements, R. Turk, R. Campbell, K. Wright, K. M. 2017-03-29 doi:10.1101/121756 Cold Spring Harbor Laboratory Press 2017-03-29 <![CDATA[ Surgically disconnected temporal pole exhibits resting functional connectivity with remote brain regions ]]> https://biorxiv.org/content/10.1101/127571v1?rss=1 Warren, D. E. Sutterer, M. J. Bruss, J. Abel, T. J. Jones, A. Kawasaki, H. Voss, M. Cassell, M. Howard, M. A. Tranel, D. 2017-04-15 doi:10.1101/127571 Cold Spring Harbor Laboratory Press 2017-04-15 <![CDATA[ Evolutionarily Conserved Roles For Blood-Brain Barrier Xenobiotic Transporters In Endogenous Steroid Partitioning And Behavior ]]> https://biorxiv.org/content/10.1101/131698v1?rss=1 Hindle, S. Munji, R. Dolghih, E. Gaskins, G. Orng, S. Ishimoto, H. Soung, A. DeSalvo, M. Kitamoto, T. Keiser, M. Jacobson, M. Daneman, R. Bainton, R. 2017-04-29 doi:10.1101/131698 Cold Spring Harbor Laboratory Press 2017-04-29 <![CDATA[ COPI Mediates Recycling Of An Exocytic SNARE From Endosomes By Recognition Of A Ubiquitin Sorting Signal ]]> https://biorxiv.org/content/10.1101/133546v1?rss=1 Xu, P. Hankins, H. Macdonald, C. Erlinger, S. J. Frazier, M. Diab, N. S. Piper, R. C. Jackson, L. P. MacGurn, J. A. Graham, T. R. 2017-05-03 doi:10.1101/133546 Cold Spring Harbor Laboratory Press 2017-05-03 <![CDATA[ Conformational Dynamics In TRPV1 Channels Reported By An Encoded Coumarin Amino Acid ]]> https://biorxiv.org/content/10.1101/137778v1?rss=1 Steinberg, X. Kasimova, M. A. Cabezas-Bratesco, D. Galpin, J. Ladron de Guevara, E. Villa, F. Carnevale, V. Islas, L. D. Ahern, C. A. Brauchi, S. E. 2017-05-14 doi:10.1101/137778 Cold Spring Harbor Laboratory Press 2017-05-14 <![CDATA[ The Oropharynx As A Distinct Colonization Site For Staphylococcus aureus In The Community ]]> https://biorxiv.org/content/10.1101/137901v1?rss=1 Hanson, B. M. Kates, A. E. Mills, E. Herwaldt, L. A. Torner, J. C. Dawson, J. D. Smith, T. C. 2017-05-15 doi:10.1101/137901 Cold Spring Harbor Laboratory Press 2017-05-15 <![CDATA[ Drosophila CaV2 Channels Harboring Human Migraine Mutations Cause Synapse Hyperexcitability That Can Be Suppressed By Inhibition Of A Ca2+ Store Release Pathway ]]> https://biorxiv.org/content/10.1101/141366v1?rss=1 Brusich, D. J. Spring, A. M. James, T. D. Helms, T. H. Frank, C. A. 2017-05-23 doi:10.1101/141366 Cold Spring Harbor Laboratory Press 2017-05-23 <![CDATA[ TiSAn: Tissue Specific Variant Annotation ]]> https://biorxiv.org/content/10.1101/141408v1?rss=1 Vervier, K. Michaelson, J. J. 2017-05-24 doi:10.1101/141408 Cold Spring Harbor Laboratory Press 2017-05-24 <![CDATA[ Staphylococcus aureus Colonization And Familial Transmission Over A One Year Period ]]> https://biorxiv.org/content/10.1101/144782v1?rss=1 Hanson, B. M. Kates, A. E. O'Malley, S. M. Mills, E. Herwaldt, L. A. Torner, J. C. Dawson, J. D. Farina, S. A. Klostermann, C. Smith, T. C. 2017-06-02 doi:10.1101/144782 Cold Spring Harbor Laboratory Press 2017-06-02 <![CDATA[ The Nasal And Oropharyngeal Microbiomes Of Healthy Livestock Workers ]]> https://biorxiv.org/content/10.1101/145029v1?rss=1 Kates, A. Dalman, M. Torner, J. Smith, T. C. 2017-06-02 doi:10.1101/145029 Cold Spring Harbor Laboratory Press 2017-06-02 <![CDATA[ A Cross-Sectional Study Of Staphylococcus aureus Colonization And The Nasal And Oropharyngeal Microbiomes ]]> https://biorxiv.org/content/10.1101/145540v1?rss=1 Kates, A. Dalman, M. Torner, J. Smith, T. 2017-06-02 doi:10.1101/145540 Cold Spring Harbor Laboratory Press 2017-06-02 <![CDATA[ Olfactory learning modulates the expression of molecular chaperones in C. elegans ]]> https://biorxiv.org/content/10.1101/152736v1?rss=1 Ooi, F. K. Prahlad, V. 2017-06-20 doi:10.1101/152736 Cold Spring Harbor Laboratory Press 2017-06-20 <![CDATA[ A model-free method for measuring dimerization free energies of CLC-ec1 in lipid bilayers ]]> https://biorxiv.org/content/10.1101/154286v1?rss=1 Chadda, R. Cliff, L. Brimberry, M. Robertson, J. L. 2017-06-23 doi:10.1101/154286 Cold Spring Harbor Laboratory Press 2017-06-23 <![CDATA[ Response to Editas: Unexpected mutations after CRISPR-Cas9 editing in vivo ]]> https://biorxiv.org/content/10.1101/154450v1?rss=1 Schaefer, K. A. Wu, W.-H. Colgan, D. F. Tsang, S. H. Bassuk, A. G. Mahajan, V. B. 2017-06-23 doi:10.1101/154450 Cold Spring Harbor Laboratory Press 2017-06-23 <![CDATA[ Synaptic homeostasis at the Drosophila neuromuscular junction is a reversible signaling process that is sensitive to high temperature ]]> https://biorxiv.org/content/10.1101/154930v1?rss=1 Yeates, C. J. Frank, C. A. 2017-06-25 doi:10.1101/154930 Cold Spring Harbor Laboratory Press 2017-06-25 <![CDATA[ SWELL1 is a glucose sensor required for β-cell excitability and insulin secretion ]]> https://biorxiv.org/content/10.1101/155093v1?rss=1 Kang, C. Gunasekar, S. K. Mishra, A. Xie, L. Zhang, Y. Pai, S. Gao, Y. Norris, A. W. Stephens, S. B. Sah, R. 2017-06-24 doi:10.1101/155093 Cold Spring Harbor Laboratory Press 2017-06-24 <![CDATA[ Macrophage-to-sensory neuron crosstalk mediated by Angiotensin II type-2 receptor elicits neuropathic pain ]]> https://biorxiv.org/content/10.1101/166546v1?rss=1 Shepherd, A. J. Mickle, A. D. Copits, B. A. Karlsson, P. Kadunganattil, S. Golden, J. P. Tadinada, S. M. Mack, M. R. Haroutounian, S. de Kloet, A. D. Samineni, V. K. Valtcheva, M. V. McIlvried, L. A. Sheahan, T. D. Jain, S. Ray, P. R. Usachev, Y. M. Dussor, G. Kim, B. S. Krause, E. G. Price, T. J. Gereau, R. W. Mohapatra, D. P. 2017-08-25 doi:10.1101/166546 Cold Spring Harbor Laboratory Press 2017-08-25 <![CDATA[ The Correlation between MicroRNA-199a and White Adipose Tissue in C57/BL6J Mice with High-Fat Diet ]]> https://biorxiv.org/content/10.1101/167783v1?rss=1 Liu, D. Wang, X. Lin, X. Zhang, B. Wang, S. Bao, W. 2017-07-24 doi:10.1101/167783 Cold Spring Harbor Laboratory Press 2017-07-24 <![CDATA[ Genome variation and conserved regulation identify genomic regions responsible for strain specific phenotypes in rat ]]> https://biorxiv.org/content/10.1101/169748v1?rss=1 Martin-Galvez, D. Dunoyer-de-Segonzac, D. Ma, M. C. J. Kwitek, A. E. Thybert, D. Flicek, P. 2017-07-28 doi:10.1101/169748 Cold Spring Harbor Laboratory Press 2017-07-28 <![CDATA[ Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide ]]> https://biorxiv.org/content/10.1101/173831v1?rss=1 Satizabal, C. L. Adams, H. H. H. Hibar, D. P. White, C. C. Stein, J. L. Scholz, M. Sargurupremraj, M. Jahanshad, N. Smith, A. V. Bis, J. C. Jian, X. Luciano, M. Hofer, E. Teumer, A. van der Lee, S. J. Yang, J. Yanek, L. R. Lee, T. V. Li, S. Hu, Y. Koh, J. Y. Eicher, J. D. Desrivieres, S. Arias-Vasquez, A. Chauhan, G. Athanasiu, L. Renteria, M. E. Kim, S. Hohn, D. Armstrong, N. J. Chen, Q. Holmes, A. J. den Braber, A. Kloszewska, I. Andersson, M. Espeseth, T. Grimm, O. Abramovic, L. Alhusaini, S. Milaneschi, Y. Papmeyer, M. Axelsson, T. Ehrlich, S. Roi 2017-08-28 doi:10.1101/173831 Cold Spring Harbor Laboratory Press 2017-08-28 <![CDATA[ SelexGLM differentiates androgen and glucocorticoid receptor DNA-binding preference over an extended binding site ]]> https://biorxiv.org/content/10.1101/176073v1?rss=1 Zhang, L. Martini, G. Rube, H. T. Kribelbauer, J. F. Rastogi, C. FitzPatrick, V. D. Houtman, J. C. Bussemaker, H. J. Pufall, M. A. 2017-08-14 doi:10.1101/176073 Cold Spring Harbor Laboratory Press 2017-08-14 <![CDATA[ The effect of sequence mismatches on binding affinity and endonuclease activity are decoupled throughout the Cas9 binding site ]]> https://biorxiv.org/content/10.1101/176255v1?rss=1 Zhang, L. Rube, H. T. Bussemaker, H. J. Pufall, M. A. 2017-08-14 doi:10.1101/176255 Cold Spring Harbor Laboratory Press 2017-08-14 <![CDATA[ Pervasive epistasis in cell proliferation pathways modulates neurodevelopmental defects of autism-associated 16p11.2 deletion ]]> https://biorxiv.org/content/10.1101/185355v1?rss=1 Iyer, J. Singh, M. D. Jensen, M. Patel, P. Pizzo, L. Huber, E. Koerselman, H. Weiner, A. T. Lepanto, P. Vadodaria, K. Kubina, A. Wang, Q. Talbert, A. Yennawar, S. Badano, J. Manak, J. R. Rolls, M. M. Krishnan, A. Girirajan, S. 2017-09-20 doi:10.1101/185355 Cold Spring Harbor Laboratory Press 2017-09-20 <![CDATA[ Distinct selection mechanisms for when predictions and rewards guide visual selective attention ]]> https://biorxiv.org/content/10.1101/188045v1?rss=1 Garner, K. G. Raymond, J. E. 2017-09-12 doi:10.1101/188045 Cold Spring Harbor Laboratory Press 2017-09-12 <![CDATA[ Receptor-mediated Drp1 oligomerization on endoplasmic reticulum ]]> https://biorxiv.org/content/10.1101/190538v1?rss=1 Ji, W.-K. Chakrabarti, R. Fan, X. Schoenfeld, L. Strack, S. Higgs, H. N. 2017-09-18 doi:10.1101/190538 Cold Spring Harbor Laboratory Press 2017-09-18 <![CDATA[ The neurobiology of agrammatic sentence comprehension: a lesion study ]]> https://biorxiv.org/content/10.1101/192245v1?rss=1 80% on noncanonical sentences in the sentence-picture matching task. Patients with ATL damage (n=18) also did not exhibit an agrammatic comprehension pattern. Across our entire patient sample, the lesions of patients with agrammatic comprehension patterns in either task had maximal overlap in posterior superior temporal and inferior parietal regions. Using voxel-based lesion symptom mapping (VLSM), we find that lower performances on canonical and noncanonical sentences in each task are both associated with damage to a large left superior temporal-inferior parietal network including portions of the ATL, but not Brocas area. Notably however, response bias in plausibility judgments was significantly associated with damage to inferior frontal cortex, including gray and white matter in Brocas area, suggesting that the contribution of Brocas area to sentence comprehension may be related to task-related cognitive demands. ]]> Rogalsky, C. LaCroix, A. N. Chen, K.-H. Anderson, S. W. Damasio, H. Love, T. Hickok, G. 2017-09-22 doi:10.1101/192245 Cold Spring Harbor Laboratory Press 2017-09-22 <![CDATA[ Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect susceptibility to developmental polychlorinated biphenyl exposure in mice: Relevance to studies of human neurological disorders ]]> https://biorxiv.org/content/10.1101/194472v1?rss=1 Klinefelter, K. Hooven, M. K. Bates, C. Colter, B. T. Dailey, A. Infante, S. K. Kania-Korwel, I. Lehmler, H.-J. Lopez-Juarez, A. Ludwig, C. P. Curran, C. P. 2017-09-27 doi:10.1101/194472 Cold Spring Harbor Laboratory Press 2017-09-27 <![CDATA[ Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium ]]> https://biorxiv.org/content/10.1101/196634v1?rss=1 Kong, X.-Z. Mathias, S. Guadalupe, T. Abe, C. Agartz, I. Akudjedu, T. N. Aleman, A. Alhusaini, S. Allen, N. B. Ames, D. Andreassen, O. A. Armstrong, N. J. Bergo, F. Bastin, M. E. Batalla, A. Bauer, J. Baune, B. Baur, R. Biederman, J. Blaine, S. K. Boedhoe, P. Boen, E. Bose, A. Bralten, J. Brandeis, D. Brem, S. Brodaty, H. Bröhl, H. Buitelaar, J. Bürger, C. Bülow, R. Calhoun, V. Calvo, A. Canales-Rodriguez, E. J. Canive, J. M. Cannon, D. M. Caparelli, E. C. Castellanos, F. X. Cavalleri, G. L. Cendes, F. Chaim-Avancini, T. M. Chant 2017-10-01 doi:10.1101/196634 Cold Spring Harbor Laboratory Press 2017-10-01 <![CDATA[ Localization of the signal of dystonia-associated protein torsinA near the Golgi apparatus in cultured central neurons ]]> https://biorxiv.org/content/10.1101/2019.12.11.872804v1?rss=1 Iwabuchi, S. Kawano, H. Harata, N. C. 2019-12-12 doi:10.1101/2019.12.11.872804 Cold Spring Harbor Laboratory Press 2019-12-12 <![CDATA[ Localization of immunoreactive, dystonia-associated protein torsinA near the Golgi apparatus of cultured rodent astrocytes ]]> https://biorxiv.org/content/10.1101/2019.12.11.873554v1?rss=1 Iwabuchi, S. Kawano, H. Harata, N. C. 2019-12-12 doi:10.1101/2019.12.11.873554 Cold Spring Harbor Laboratory Press 2019-12-12 <![CDATA[ Staphylococcal Enterotoxin C promotes Staphylococcus aureus Infective Endocarditis Independent of Superantigen Activity ]]> https://biorxiv.org/content/10.1101/2019.12.13.875633v1?rss=1 Kinney, K. J. Tran, P. M. Gibson-Corley, K. N. Forsythe, A. N. Kulhankova, K. Salgado-Pabon, W. 2019-12-13 doi:10.1101/2019.12.13.875633 Cold Spring Harbor Laboratory Press 2019-12-13 <![CDATA[ TF protein of Sindbis virus antagonizes host type I interferon responses in a palmitoylation-dependent manner ]]> https://biorxiv.org/content/10.1101/2019.12.13.875781v1?rss=1 Rogers, K. Jones-Burrage, S. Maury, W. Mukhopadhyay, S. 2019-12-13 doi:10.1101/2019.12.13.875781 Cold Spring Harbor Laboratory Press 2019-12-13 <![CDATA[ Gene regulatory networks associated with lateral root and nodule development in soybean ]]> https://biorxiv.org/content/10.1101/2019.12.15.876995v1?rss=1 Smita, S. Kiehne, J. Adhikari, S. Zeng, E. Ma, Q. Subramanian, S. 2019-12-16 doi:10.1101/2019.12.15.876995 Cold Spring Harbor Laboratory Press 2019-12-16 <![CDATA[ Semecarpus anacardium Linn. leaf extract exhibits activities against breast cancer and prolongs the survival of tumor bearing mice ]]> https://biorxiv.org/content/10.1101/2020.01.08.898940v1?rss=1 View larger version (45K): org.highwire.dtl.DTLVardef@3fefborg.highwire.dtl.DTLVardef@594510org.highwire.dtl.DTLVardef@c525d2org.highwire.dtl.DTLVardef@1362978_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Singh, R. K. Ranjan, A. Tripathi, R. Verma, S. S. Sharma, V. Singh, M. Gupta, S. C. Singh, A. K. Singh, S. K. 2020-01-09 doi:10.1101/2020.01.08.898940 Cold Spring Harbor Laboratory Press 2020-01-09 <![CDATA[ Suppression of Cytotoxic T Cell Functions and Decreased Levels of Tissue Resident Memory T cell During H5N1 infection ]]> https://biorxiv.org/content/10.1101/2020.01.09.901132v1?rss=1 Kandasamy, M. Furlong, K. Perez, J. T. Manicassamy, S. Manicassamy, B. 2020-01-10 doi:10.1101/2020.01.09.901132 Cold Spring Harbor Laboratory Press 2020-01-10 <![CDATA[ Differential contributions of synaptic and intrinsic inhibitory currents to parsing via flexible phase-locking in neural oscillators ]]> https://biorxiv.org/content/10.1101/2020.01.11.902858v1?rss=1 Pittman-Polletta, B. R. Wang, Y. Stanley, D. A. Schroeder, C. E. Whittington, M. A. Kopell, N. J. 2020-01-13 doi:10.1101/2020.01.11.902858 Cold Spring Harbor Laboratory Press 2020-01-13 <![CDATA[ Invertebrate Community Associated with the Asexual Generation of Bassettia pallida Ashmead (Hymenoptera: Cynipidae) ]]> https://biorxiv.org/content/10.1101/2020.01.17.909648v1?rss=1 Weinersmith, K. L. Forbes, A. A. Ward, A. K. G. Brandao-Dias, P. F. P. Zhang, Y. M. Egan, S. P. 2020-01-17 doi:10.1101/2020.01.17.909648 Cold Spring Harbor Laboratory Press 2020-01-17 <![CDATA[ Serotonin signaling by maternal neurons upon stress ensures progeny survival ]]> https://biorxiv.org/content/10.1101/2020.01.20.913038v1?rss=1 Das, S. Ooi, F. K. Cruz Corchado, J. Fuller, L. C. C. Weiner, J. A. Prahlad, V. 2020-01-21 doi:10.1101/2020.01.20.913038 Cold Spring Harbor Laboratory Press 2020-01-21 <![CDATA[ Reduced function of the glutathione S-transferase S1 suppresses behavioral hyperexcitability in Drosophila expressing a mutant voltage-gated sodium channel ]]> https://biorxiv.org/content/10.1101/2020.01.21.906156v1?rss=1 Chen, H.-L. Kasuya, J. Lansdon, P. Kaas, G. A. Tang, H. Sodders, M. Kitamoto, T. 2020-01-21 doi:10.1101/2020.01.21.906156 Cold Spring Harbor Laboratory Press 2020-01-21 <![CDATA[ Self-generated whisker movements drive state-dependent sensory input to developing barrel cortex ]]> https://biorxiv.org/content/10.1101/2020.01.21.914259v1?rss=1 Dooley, J. C. Glanz, R. M. Sokoloff, G. Blumberg, M. S. 2020-01-23 doi:10.1101/2020.01.21.914259 Cold Spring Harbor Laboratory Press 2020-01-23 <![CDATA[ Divided Attention in Perception:A Unified Analysis of Dual-Task Deficits and Congruency Effects ]]> https://biorxiv.org/content/10.1101/2020.01.23.917492v1?rss=1 Palmer, J. White, A. L. Moore, C. M. Boynton, G. M. 2020-01-24 doi:10.1101/2020.01.23.917492 Cold Spring Harbor Laboratory Press 2020-01-24 <![CDATA[ Buildup and bistability in auditory streaming as an evidence accumulation process with saturation ]]> https://biorxiv.org/content/10.1101/2020.01.24.917799v1?rss=1 Nguyen, Q.-A. Rinzel, J. Curtu, R. 2020-01-25 doi:10.1101/2020.01.24.917799 Cold Spring Harbor Laboratory Press 2020-01-25 <![CDATA[ Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human KRT8/18 ]]> https://biorxiv.org/content/10.1101/2020.01.27.921320v1?rss=1 Liu, H. Duncan, K. Helverson, A. Kumari, P. Mumm, C. Xiao, Y. Carlson, J. C. Darbellay, F. Visel, A. Leslie, E. Breheny, P. Erives, A. J. Cornell, R. 2020-01-28 doi:10.1101/2020.01.27.921320 Cold Spring Harbor Laboratory Press 2020-01-28 <![CDATA[ Brown Adipose Tissue is Associated with Improved Cardiometabolic Health and Regulates Blood Pressure ]]> https://biorxiv.org/content/10.1101/2020.02.08.933754v1?rss=1 Becher, T. Palanisamy, S. Kramer, D. J. Marx, S. J. Wibmer, A. G. Del Gaudio, I. Butler, S. D. Jiang, C. S. Vaughan, R. Schoder, H. Di Lorenzo, A. Mark, A. Cohen, P. 2020-02-10 doi:10.1101/2020.02.08.933754 Cold Spring Harbor Laboratory Press 2020-02-10 <![CDATA[ Importin-9 regulates chromosome segregation and packaging in Drosophila germ cells ]]> https://biorxiv.org/content/10.1101/2020.02.10.942326v1?rss=1 Palacios, V. Kimble, G. C. Tootle, T. L. Buszczak, M. 2020-02-10 doi:10.1101/2020.02.10.942326 Cold Spring Harbor Laboratory Press 2020-02-10 <![CDATA[ Mitochondrial CaMKII causes metabolic reprogramming, energetic insufficiency, and dilated cardiomyopathy ]]> https://biorxiv.org/content/10.1101/2020.02.13.947564v1?rss=1 Luczak, E. D. Wu, Y. Granger, J. M. Joiner, M.-l. A. Wilson, N. R. Gupta, A. Umapathi, P. Murphy, K. R. Reyes Gaido, O. E. Sabet, A. Corradini, E. Wang, Y. Heck, A. J. Wei, A.-C. Weiss, R. G. Anderson, M. E. 2020-02-14 doi:10.1101/2020.02.13.947564 Cold Spring Harbor Laboratory Press 2020-02-14 <![CDATA[ O-GlcNAcylation and oxidation contribute to atrial fibrillation in diabetes by activating CaMKII ]]> https://biorxiv.org/content/10.1101/2020.02.18.954909v1?rss=1 Mesubi, O. O. Rokita, A. G. Abrol, N. Wu, Y. Chen, B. Wang, Q. Granger, J. M. Luczak, E. D. Banerjee, P. S. Maier, L. S. Wehrens, X. H. Pomerantz, J. L. Song, L.-S. Ahima, R. S. Zachara, N. E. Hart, G. W. Anderson, M. E. 2020-02-19 doi:10.1101/2020.02.18.954909 Cold Spring Harbor Laboratory Press 2020-02-19 <![CDATA[ Modulation of the Cardiac Sodium Channel Nav1.5 Peak and Late Currents by NAD+ Precursors ]]> https://biorxiv.org/content/10.1101/2020.02.20.958066v1?rss=1 Matasic, D. Yoon, J.-Y. McLendon, J. M. Mehdi, H. Schmidt, M. S. Greiner, A. M. Quinones, P. Morgan, G. M. Boudreau, R. L. Irani, K. Brenner, C. London, B. 2020-02-24 doi:10.1101/2020.02.20.958066 Cold Spring Harbor Laboratory Press 2020-02-24 <![CDATA[ Mechanisms preventing Break-Induced Replication during repair of two-ended DNA double-strand breaks ]]> https://biorxiv.org/content/10.1101/2020.02.28.969154v1?rss=1 Ira, G. Pham, N. Yan, Z. Haber, J. E. Malkova, A. 2020-02-28 doi:10.1101/2020.02.28.969154 Cold Spring Harbor Laboratory Press 2020-02-28 <![CDATA[ Temporal learning among prefrontal and striatal ensembles ]]> https://biorxiv.org/content/10.1101/2020.02.28.970053v1?rss=1 Emmons, E. B. Chiuffa Tunes, G. Choi, J. Bruce, R. A. Weber, M. Kim, Y. Narayanan, N. 2020-03-02 doi:10.1101/2020.02.28.970053 Cold Spring Harbor Laboratory Press 2020-03-02 <![CDATA[ Risk of preeclampsia in patients with genetic predisposition to common medical conditions: a case-control study ]]> https://biorxiv.org/content/10.1101/2020.03.04.976472v1?rss=1 Gray, K. J. Kovacheva, V. P. Mirzakhani, H. Bjonnes, A. C. Almoguera, B. Wilson, M. L. Ingles, S. A. Lockwood, C. J. Hakonarson, H. McElrath, T. F. Murray, J. C. Norwitz, E. R. Karumanchi, S. A. Bateman, B. T. Keating, B. J. Saxena, R. 2020-03-05 doi:10.1101/2020.03.04.976472 Cold Spring Harbor Laboratory Press 2020-03-05 <![CDATA[ Integration of anatomy ontology data with protein-protein interaction networks improves the candidate gene prediction accuracy for anatomical entities ]]> https://biorxiv.org/content/10.1101/2020.03.07.981795v1?rss=1 Fernando, P. C. Mabee, P. M. Zeng, E. 2020-03-08 doi:10.1101/2020.03.07.981795 Cold Spring Harbor Laboratory Press 2020-03-08 <![CDATA[ The superoxide dismutase mimetic GC4419 enhances tumor killing when combined with stereotactic ablative radiation ]]> https://biorxiv.org/content/10.1101/2020.03.10.984443v1?rss=1 Sishc, B. J. Ding, L. Heer, C. Saha, D. Spitz, D. Story, M. D. 2020-03-11 doi:10.1101/2020.03.10.984443 Cold Spring Harbor Laboratory Press 2020-03-11 <![CDATA[ Host shifting and host sharing in a genus of specialist flies diversifying alongside their sunflower hosts ]]> https://biorxiv.org/content/10.1101/2020.03.18.995589v1?rss=1 1 species onto the same shared host plants. ]]> Hippee, A. C. Beer, M. A. Bagley, R. K. Condon, M. A. Kitchen, A. Lisowski, E. A. Norrbom, A. L. Forbes, A. A. 2020-03-20 doi:10.1101/2020.03.18.995589 Cold Spring Harbor Laboratory Press 2020-03-20 <![CDATA[ Gatekeeper transcription factors regulate switch between lineage preservation and cell plasticity ]]> https://biorxiv.org/content/10.1101/2020.03.19.999433v1?rss=1 View larger version (25K): org.highwire.dtl.DTLVardef@1acdb83org.highwire.dtl.DTLVardef@17fb3ddorg.highwire.dtl.DTLVardef@f994c9org.highwire.dtl.DTLVardef@197541e_HPS_FORMAT_FIGEXP M_FIG C_FIG Schematic diagram depicting transdifferentiation of REFs into adipocytes, osteocytes, chondrocytes and dedifferentiation into MSCs on individual treatment with siSnai2 or siPrrx1. dPSCs were generated only in the siSnai2 group. ]]> Ray, T. Shah, A. Bulla, G. A. Ray, P. S. 2020-03-20 doi:10.1101/2020.03.19.999433 Cold Spring Harbor Laboratory Press 2020-03-20 <![CDATA[ Presynaptically silent synapses are modulated by the density of surrounding astrocytes ]]> https://biorxiv.org/content/10.1101/2020.03.20.000166v1?rss=1 Oyabu, K. Takeda, K. Kawano, H. Kubota, K. Watanabe, T. Harata, N. C. Katsurabayashi, S. Iwasaki, K. 2020-03-21 doi:10.1101/2020.03.20.000166 Cold Spring Harbor Laboratory Press 2020-03-21 <![CDATA[ IL8 Drives an Elaborate Signal Transduction Process for CD38 to Produce NAADP from NAAD and NADP+ in Endolysosomes to Effect Cell Migration ]]> https://biorxiv.org/content/10.1101/2020.03.24.004739v1?rss=1 Nam, T.-S. Park, D.-R. Rah, S.-Y. Woo, T.-G. Chung, H. T. Brenner, C. Kim, U.-H. 2020-03-25 doi:10.1101/2020.03.24.004739 Cold Spring Harbor Laboratory Press 2020-03-25 <![CDATA[ Non-selective inhibition of the motor system following unexpected and expected infrequent events ]]> https://biorxiv.org/content/10.1101/2020.03.25.008789v1?rss=1 Iacullo, C. Diesburg, D. A. Wessel, J. R. 2020-03-26 doi:10.1101/2020.03.25.008789 Cold Spring Harbor Laboratory Press 2020-03-26 <![CDATA[ Identification of a Novel PP2A Regulator, WNK1, as Critical For Uterine Function ]]> https://biorxiv.org/content/10.1101/2020.03.27.012039v1?rss=1 Chi, R.-p. A. Wang, T. Huang, C.-l. Wu, S.-P. Young, S. L. Lydon, J. P. DeMayo, F. J. 2020-03-29 doi:10.1101/2020.03.27.012039 Cold Spring Harbor Laboratory Press 2020-03-29 <![CDATA[ The NAD Metabolome is Functionally Depressed in Patients Undergoing Liver Transplantation for Alcohol-related Liver Disease ]]> https://biorxiv.org/content/10.1101/2020.03.28.013581v1?rss=1 Parker, R. Schmidt, M. S. Cain, O. Gunson, B. Brenner, C. 2020-03-30 doi:10.1101/2020.03.28.013581 Cold Spring Harbor Laboratory Press 2020-03-30 <![CDATA[ Coding de novo mutations identified by WGS reveal novel orofacial cleft genes ]]> https://biorxiv.org/content/10.1101/2020.04.01.019927v1?rss=1 Bishop, M. Diaz Perez, K. Sun, M. Ho, S. Chopra, P. Mukhopadhyay, N. Hetmanski, J. Taub, M. Moreno-Uribe, L. Valencia-Ramirez, L. C. Restrepo Muneton, C. Wehby, G. Hecht, J. Deleyiannis, F. Weinberg, S. Wu-Chou, Y. H. Chen, P. Brand, H. Epstein, M. Ruczinski, I. Murray, J. Beaty, T. Feingold, E. Lipinski, R. Cutler, D. Marazita, M. Leslie, E. 2020-04-02 doi:10.1101/2020.04.01.019927 Cold Spring Harbor Laboratory Press 2020-04-02 <![CDATA[ The Neuroanatomy of Speech Processing: A Large-Scale Lesion Study ]]> https://biorxiv.org/content/10.1101/2020.04.02.022822v1?rss=1 Rogalsky, C. Basilakos, A. Rorden, C. Pillay, S. LaCroix, A. N. Keator, L. Mickelsen, S. Anderson, S. W. Love, T. Fridriksson, J. Binder, J. Hickok, G. 2020-04-03 doi:10.1101/2020.04.02.022822 Cold Spring Harbor Laboratory Press 2020-04-03 <![CDATA[ Common Fronto-temporal Effective Connectivity in Humans and Monkeys ]]> https://biorxiv.org/content/10.1101/2020.04.03.024042v1?rss=1 Rocchi, F. Oya, H. Balezeau, F. Billig, A. J. Kocsis, Z. Jenison, R. Nourski, K. V. Kovach, C. K. Steinschneider, M. Kikuchi, Y. Rhone, A. E. Dlouhy, B. J. Kawasaki, H. Adolphs, R. Greenlee, J. D. W. Griffiths, T. D. Howard, M. A. Petkov, C. I. 2020-04-05 doi:10.1101/2020.04.03.024042 Cold Spring Harbor Laboratory Press 2020-04-05 <![CDATA[ POMK Regulates Dystroglycan Function via LARGE-mediated Elongation of Matriglycan ]]> https://biorxiv.org/content/10.1101/2020.04.06.007948v1?rss=1 Walimbe, A. S. Yang, T. Yonekawa, T. Venzke, D. Anderson, M. E. Torelli, S. Manzur, A. Yu, L. Devereaux, M. Cuellar, M. Prouty, S. O'Campo Landa, S. Muntoni, F. Campbell, K. P. 2020-04-07 doi:10.1101/2020.04.06.007948 Cold Spring Harbor Laboratory Press 2020-04-07 <![CDATA[ MgrA regulates interaction of Staphylococcus aureus with mucin ]]> https://biorxiv.org/content/10.1101/2020.04.09.035261v1?rss=1 Parker, C. P. Akil, N. Shanrock, C. R. Allen, P. D. Chaly, A. L. Crosby, H. Kwiecinski, J. Horswill, A. R. Fischer, A. J. 2020-04-10 doi:10.1101/2020.04.09.035261 Cold Spring Harbor Laboratory Press 2020-04-10 <![CDATA[ Visualizing Rev1 Catalyze Protein-template DNA Synthesis ]]> https://biorxiv.org/content/10.1101/2020.04.10.036236v1?rss=1 Weaver, T. M. Cortez, L. M. Khoang, T. H. Washington, M. T. Agarwal, P. Freudenthal, B. D. 2020-04-12 doi:10.1101/2020.04.10.036236 Cold Spring Harbor Laboratory Press 2020-04-12 <![CDATA[ Optogenetic stimulation of the basolateral amygdala-medial entorhinal cortex pathway after spatial training has sex-specific effects on downstream activity-regulated cytoskeletal-associated protein expression ]]> https://biorxiv.org/content/10.1101/2020.04.15.042812v1?rss=1 Wahlstrom, K. L. Alvarez-Dieppa, A. McIntyre, C. K. LaLumiere, R. T. 2020-04-17 doi:10.1101/2020.04.15.042812 Cold Spring Harbor Laboratory Press 2020-04-17 <![CDATA[ Unexpected sounds non-selectively inhibit active visual stimulus representations ]]> https://biorxiv.org/content/10.1101/2020.04.16.044966v1?rss=1 Soh, C. Wessel, J. R. 2020-04-18 doi:10.1101/2020.04.16.044966 Cold Spring Harbor Laboratory Press 2020-04-18 <![CDATA[ Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity ]]> https://biorxiv.org/content/10.1101/2020.04.17.047480v1?rss=1 Heer, C. D. Sanderson, D. J. Alhammad, Y. M. O. Schmidt, M. S. Trammell, S. A. J. Perlman, S. Cohen, M. S. Fehr, A. R. Brenner, C. 2020-04-18 doi:10.1101/2020.04.17.047480 Cold Spring Harbor Laboratory Press 2020-04-18 <![CDATA[ HSV Forms an HCMV-like Viral Assembly Center in Neuronal Cells ]]> https://biorxiv.org/content/10.1101/2020.04.22.055145v1?rss=1 White, S. Kawano, H. Harata, N. C. Roller, R. J. 2020-04-23 doi:10.1101/2020.04.22.055145 Cold Spring Harbor Laboratory Press 2020-04-23 <![CDATA[ Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract ]]> https://biorxiv.org/content/10.1101/2020.04.22.056127v1?rss=1 Ortiz Bezara, M. E. Thurman, A. Pezzulo, A. Leidinger, M. R. Klesney-Tait, J. A. Karp, P. H. Tan, P. Wohlford-Lenane, C. McCray, P. B. Meyerholz, D. K. 2020-04-23 doi:10.1101/2020.04.22.056127 Cold Spring Harbor Laboratory Press 2020-04-23 <![CDATA[ Locally-invasive, castrate-resistant prostate cancer in a Pten/Trp53 double knockout mouse model of prostate cancer monitored with non-invasive bioluminescent imaging ]]> https://biorxiv.org/content/10.1101/2020.04.23.057661v1?rss=1 Yong, C. Moose, D. Bannick, N. Vanneste, M. Svensson, R. Breheny, P. Brown, J. Cohen, M. Henry, M. 2020-04-23 doi:10.1101/2020.04.23.057661 Cold Spring Harbor Laboratory Press 2020-04-23 <![CDATA[ Identification and Characterization of Fbxl22, a novel skeletal muscle atrophy-promoting E3 ubiquitin ligase ]]> https://biorxiv.org/content/10.1101/2020.04.24.059659v1?rss=1 Hughes, D. C. Baehr, L. M. Driscoll, J. R. Lynch, S. A. Waddell, D. S. Bodine, S. C. 2020-04-25 doi:10.1101/2020.04.24.059659 Cold Spring Harbor Laboratory Press 2020-04-25 <![CDATA[ Regular physical activity reduces the percentage of spinally projecting neurons that express mu-opioid receptors from the RVM ]]> https://biorxiv.org/content/10.1101/2020.04.27.064923v1?rss=1 Sluka, K. Kolker, S. J. Danielson, J. Rasmussen, L. 2020-04-28 doi:10.1101/2020.04.27.064923 Cold Spring Harbor Laboratory Press 2020-04-28 <![CDATA[ VCFdbR: A method for expressing biobank-scale Variant Call Format data in a SQLite database using R ]]> https://biorxiv.org/content/10.1101/2020.04.28.066894v1?rss=1 Koomar, T. Michaelson, J. 2020-04-29 doi:10.1101/2020.04.28.066894 Cold Spring Harbor Laboratory Press 2020-04-29 <![CDATA[ Invasive freshwater snails form novel microbial symbioses ]]> https://biorxiv.org/content/10.1101/2020.04.29.069013v1?rss=1 Bankers, L. Dahan, D. Neiman, M. Adrian-Tucci, C. Frost, C. Hurst, G. King, K. 2020-04-30 doi:10.1101/2020.04.29.069013 Cold Spring Harbor Laboratory Press 2020-04-30 <![CDATA[ Novel Loss-of-Function Mutations in COCH Cause Autosomal Recessive Nonsyndromic Deafness ]]> https://biorxiv.org/content/10.1101/2020.04.30.071134v1?rss=1 Booth, K. T. Ghaffar, A. Rashid, M. Hovey, L. T. Hussain, M. Frees, K. Renkes, E. M. Nishimura, C. J. Shahzad, M. Smith, R. J. H. Ahmed, Z. Azaiez, H. Riazuddin, S. 2020-05-02 doi:10.1101/2020.04.30.071134 Cold Spring Harbor Laboratory Press 2020-05-02 <![CDATA[ Pathologic α-Synuclein Species Activate LRRK2 in Pro-Inflammatory Monocyte and Macrophage Responses ]]> https://biorxiv.org/content/10.1101/2020.05.04.077065v1?rss=1 Xu, E. Boddu, R. Abdelmotilib, H. A. Kelly, K. Sokratian, A. Harms, A. S. Schonhoff, A. M. Bryant, N. Harmsen, I. E. Schlossmacher, M. Chandra, S. Krendelshchikova, V. Liu, Z. West, A. B. 2020-05-05 doi:10.1101/2020.05.04.077065 Cold Spring Harbor Laboratory Press 2020-05-05 <![CDATA[ Limited time window for retinal gene therapy in a preclinical model of ciliopathy ]]> https://biorxiv.org/content/10.1101/2020.05.05.072793v1?rss=1 Datta, P. Ruffcorn, A. Seo, S. 2020-05-06 doi:10.1101/2020.05.05.072793 Cold Spring Harbor Laboratory Press 2020-05-06 <![CDATA[ Cortical Thickness Trajectories across the Lifespan: Data from 17,075 healthy individuals aged 3-90 years ]]> https://biorxiv.org/content/10.1101/2020.05.05.077834v1?rss=1 Frangou, S. Modabbernia, A. Doucet, G. E. Papachristou, E. Williams, S. C. Agartz, I. Aghajani, M. Akudjedu, T. N. Albajes-Eizagirre, A. Alnaes, D. Alpert, K. I. Andersson, M. Andreasen, N. Andreassen, O. A. Asherson, P. Banaschewski, T. Bargallo, N. Baumeister, S. Baur-Streubel, R. Bertolino, A. Bonvino, A. Boomsma, D. I. Borgwardt, S. Bourque, J. Brandeis, D. Breier, A. Brodaty, H. Brouwer, R. M. Buitelaar, J. K. Busatto, G. F. Buckner, R. L. Calhoun, V. Canales-Rodriguez, E. J. Cannon, D. M. Caseras, X. Castellanos, F. X. Cervenka, S. Chaim-Avancini, T. 2020-05-07 doi:10.1101/2020.05.05.077834 Cold Spring Harbor Laboratory Press 2020-05-07 <![CDATA[ Subcortical Volume Trajectories across the Lifespan: Data from 18,605 healthy individuals aged 3-90 years ]]> https://biorxiv.org/content/10.1101/2020.05.05.079475v1?rss=1 Dima, D. Papachristou, E. Modabbernia, A. Doucet, G. E. Agartz, I. Aghajani, M. Akudjedu, T. N. Albajes-Eizagirre, A. Alnaes, D. Alpert, K. I. Andersson, M. Andreasen, N. Andreassen, O. A. Asherson, P. Banaschewski, T. Bargallo, N. Baumeister, S. Baur-Streubel, R. Bertolino, A. Bonvino, A. Boomsma, D. I. Borgwardt, S. Bourque, J. Brandeis, D. Breier, A. Brodaty, H. Brouwer, R. M. Buitelaar, J. K. Busatto, G. F. Buckner, R. L. Calhoun, V. Canales-Rodriguez, E. J. Cannon, D. M. Caseras, X. Castellanos, F. X. Cervenka, S. Chaim-Avancini, T. M. Ching, C. R. Cl 2020-05-07 doi:10.1101/2020.05.05.079475 Cold Spring Harbor Laboratory Press 2020-05-07 <![CDATA[ Diversity, host ranges, and potential drivers of speciation among the inquiline enemies of oak gall wasps. ]]> https://biorxiv.org/content/10.1101/2020.05.08.084699v1?rss=1 Ward, A. K. G. Sheikh, S. I. Forbes, A. A. 2020-05-10 doi:10.1101/2020.05.08.084699 Cold Spring Harbor Laboratory Press 2020-05-10 <![CDATA[ A putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic β-cells ]]> https://biorxiv.org/content/10.1101/2020.05.12.091728v1?rss=1 Li, M. Shao, F. Qian, Q. Yu, W. Zhang, Z. Chen, B. Dan, S. Guo, Y. Phan, A.-V. D. Song, L.-S. Stephens, S. B. Sebag, J. A. Imai, Y. Ling, Y. Cao, H. 2020-05-14 doi:10.1101/2020.05.12.091728 Cold Spring Harbor Laboratory Press 2020-05-14 <![CDATA[ Skeletal muscle DNMT3A plays a necessary role in endurance exercise by regulating oxidative capacity of red muscles ]]> https://biorxiv.org/content/10.1101/2020.05.18.102400v1?rss=1 Kang, S. Villivalam, S. You, D. Ebert, S. Kim, J. Xiao, H. Palacios, H. Adams, C. 2020-05-19 doi:10.1101/2020.05.18.102400 Cold Spring Harbor Laboratory Press 2020-05-19 <![CDATA[ Human es-fMRI Resource: Concurrent deep-brain stimulation and whole-brain functional MRI ]]> https://biorxiv.org/content/10.1101/2020.05.18.102657v1?rss=1 Thompson, W. H. Nair, R. Oya, H. Esteban, O. Shine, J. M. Petkov, C. Poldrack, R. A. Howard, M. Adolphs, R. 2020-05-20 doi:10.1101/2020.05.18.102657 Cold Spring Harbor Laboratory Press 2020-05-20 <![CDATA[ Abl kinase deficiency promotes AKT pathway activation and prostate cancer progression and metastasis ]]> https://biorxiv.org/content/10.1101/2020.05.19.104679v1?rss=1 Marchal, M. A. Moose, D. Varzavand, A. Taylor, D. Brown, J. A. Henry, M. D. Stipp, C. S. 2020-05-21 doi:10.1101/2020.05.19.104679 Cold Spring Harbor Laboratory Press 2020-05-21 <![CDATA[ Selective role of the translin/trax RNase complex in hippocampal synaptic plasticity ]]> https://biorxiv.org/content/10.1101/2020.05.19.105189v1?rss=1 Park, A. J. Shetty, M. S. Baraban, J. M. Abel, T. 2020-05-20 doi:10.1101/2020.05.19.105189 Cold Spring Harbor Laboratory Press 2020-05-20 <![CDATA[ Focal cortical surface cooling is a novel and safe method for intraoperative functional brain mapping ]]> https://biorxiv.org/content/10.1101/2020.05.20.104364v1?rss=1 Ibayashi, K. Cardenas, A. R. Oya, H. Kawasaki, H. Kovach, C. K. Howard, M. A. Long, M. A. Greenlee, J. D. W. 2020-05-23 doi:10.1101/2020.05.20.104364 Cold Spring Harbor Laboratory Press 2020-05-23 <![CDATA[ The p150 Isoform of ADAR1 Blocks Sustained RLR signaling and Apoptosis during Influenza Virus Infection ]]> https://biorxiv.org/content/10.1101/2020.05.23.111419v1?rss=1 Vogel, O. A. Han, J. Liang, C.-y. Manicassamy, S. Perez, J. T. Manicassamy, B. 2020-05-23 doi:10.1101/2020.05.23.111419 Cold Spring Harbor Laboratory Press 2020-05-23 <![CDATA[ HSP90 inhibition modulates NFB signaling in airway goblet cell metaplasia ]]> https://biorxiv.org/content/10.1101/2020.05.24.113902v1?rss=1 Tudas, R. A. Gannon, R. M. Thurman, A. L. Stroik, M. R. Zabner, J. Pezzulo, A. A. 2020-05-26 doi:10.1101/2020.05.24.113902 Cold Spring Harbor Laboratory Press 2020-05-26 <![CDATA[ Age- and Sex-Specific Fear Conditioning Deficits in Mice Lacking Pcdh10, an Autism Associated Gene ]]> https://biorxiv.org/content/10.1101/2020.05.25.115634v1?rss=1 Ferri, S. L. Dow, H. C. Schoch, H. Lee, J. Y. Brodkin, E. S. Abel, T. 2020-05-28 doi:10.1101/2020.05.25.115634 Cold Spring Harbor Laboratory Press 2020-05-28 <![CDATA[ Single-molecule long-read sequencing reveals a conserved selection mechanism determining intact long RNA and miRNA profiles in sperm ]]> https://biorxiv.org/content/10.1101/2020.05.28.122382v1?rss=1 Li, X. Sun, Y. H. Wang, A. Song, C. Srivastava, R. Au, K. F. 2020-05-30 doi:10.1101/2020.05.28.122382 Cold Spring Harbor Laboratory Press 2020-05-30 <![CDATA[ Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure ]]> https://biorxiv.org/content/10.1101/2020.05.29.123505v1?rss=1 Wang, H. Noordam, R. Cade, B. E. Schwander, K. Winkler, T. W. Lee, J. Sung, Y. J. Bentley, A. R. Manning, A. K. Aschard, H. Kilpelainen, T. O. Ilkov, M. Brown, M. R. Horimoto, A. R. Richard, M. Bartz, T. M. Vojinovic, D. Lim, E. Nierenberg, J. L. Liu, Y. Chitrala, K. Rankinen, T. Musani, S. K. Franceschini, N. Rauramaa, R. Alver, M. Zee, P. Harris, S. E. van der Most, P. J. Nolte, I. M. Munroe, P. B. Palmer, N. D. Kuhnel, B. Weiss, S. Wen, W. Hall, K. A. Lyytikainen, L.-P. O'Connell, J. R. Eiriksdottir, G. Launer, L. J. de Vries, P. S. Arking, D. Chen, 2020-05-31 doi:10.1101/2020.05.29.123505 Cold Spring Harbor Laboratory Press 2020-05-31 <![CDATA[ Multifactorial and closed head impact traumatic brain injuries cause distinct tactile hypersensitivity profiles ]]> https://biorxiv.org/content/10.1101/2020.06.01.127944v1?rss=1 Wattiez, A.-S. Castonguay, W. C. Gaul, O. J. Waite, J. S. Schmidt, C. M. Reis, A. S. Rea, B. J. Sowers, L. P. Cintron-Perez, C. J. Vazquez-Rosa, E. Pieper, A. A. Russo, A. F. 2020-06-02 doi:10.1101/2020.06.01.127944 Cold Spring Harbor Laboratory Press 2020-06-02 <![CDATA[ ANGPTL4 from adipose, but not liver, is responsible for regulating plasma triglyceride partitioning ]]> https://biorxiv.org/content/10.1101/2020.06.02.106815v1?rss=1 Spitler, K. M. Shetty, S. K. Cushing, E. M. Sylvers-Davie, K. L. Davies, B. S. J. 2020-06-03 doi:10.1101/2020.06.02.106815 Cold Spring Harbor Laboratory Press 2020-06-03 <![CDATA[ Rewiring PBMC responses to prevent CHIKV infection-specific monocyte subset redistribution and cytokine responses ]]> https://biorxiv.org/content/10.1101/2020.06.04.132340v1?rss=1 Aguilar Briseno, J. A. Ruiz Silva, M. Moser, J. Pauzuolis, M. Smit, J. M. Rodenhuis-Zybert, I. A. 2020-06-05 doi:10.1101/2020.06.04.132340 Cold Spring Harbor Laboratory Press 2020-06-05 <![CDATA[ SWELL1-LRRC8 complex regulates skeletal muscle cell size, intracellular signalling, adiposity and glucose metabolism ]]> https://biorxiv.org/content/10.1101/2020.06.04.134213v1?rss=1 Kumar, A. Xie, L. Ta, C. M. Hinton, A. J. Gunasekar, S. K. Minerath, R. A. Shen, K. Maurer, J. M. Grueter, C. E. Abel, E. D. Meyer, G. Sah, R. 2020-06-26 doi:10.1101/2020.06.04.134213 Cold Spring Harbor Laboratory Press 2020-06-26 <![CDATA[ UBR5 knockdown in human myotubes in-vitro and mouse skeletal muscle tissue in-vivo determines its pertinent role in anabolism and hypertrophy ]]> https://biorxiv.org/content/10.1101/2020.06.05.116145v1?rss=1 Turner, D. C. Hughes, D. C. Baehr, L. M. Seaborne, R. A. Viggars, M. Jarvis, J. C. Gorski, P. P. Stewart, C. E. Owens, D. J. Bodine, S. C. Sharples, A. P. 2020-06-06 doi:10.1101/2020.06.05.116145 Cold Spring Harbor Laboratory Press 2020-06-06 <![CDATA[ The CBP KIX domain regulates long-term memory and circadian activity ]]> https://biorxiv.org/content/10.1101/2020.06.08.130815v1?rss=1 Chatterjee, S. Angelakos, C. C. Bahl, E. Hawk, J. D. Gaine, M. E. Poplawski, S. G. Schneider-Anthony, A. Yadav, M. Porcari, G. S. Cassel, J.-C. Giese, K. P. Michaelson, J. J. Lyons, L. C. Boutillier, A.-L. Abel, T. 2020-06-09 doi:10.1101/2020.06.08.130815 Cold Spring Harbor Laboratory Press 2020-06-09 <![CDATA[ Differential causal involvement of human auditory and frontal cortices in vocal motor control ]]> https://biorxiv.org/content/10.1101/2020.06.08.139881v1?rss=1 Cardenas, A. R. Behroozmand, R. Kocsis, Z. Gander, P. E. Nourski, K. V. Kovach, C. K. Ibayashi, K. Pipoly, M. Kawasaki, H. Howard, M. A. Greenlee, J. D. 2020-06-09 doi:10.1101/2020.06.08.139881 Cold Spring Harbor Laboratory Press 2020-06-09 <![CDATA[ AP-2γ is Required for Maintenance of Pluripotent Mammary Stem Cells ]]> https://biorxiv.org/content/10.1101/2020.06.10.107078v1?rss=1 Gu, V. W. Cho, E. Thompson, D. T. Cassady, V. C. Borcherding, N. Koch, K. E. Wu, V. T. Lorenzen, A. W. Kulak, M. V. Williams, T. Zhang, W. Weigel, R. J. 2020-06-10 doi:10.1101/2020.06.10.107078 Cold Spring Harbor Laboratory Press 2020-06-10 <![CDATA[ Oscillatory correlates of auditory working memory examined with human electrocorticography ]]> https://biorxiv.org/content/10.1101/2020.06.19.161901v1?rss=1 Kumar, S. Gander, P. E. Berger, J. Billig, A. J. Nourski, K. V. Oya, H. Kawasaki, H. Howard, M. A. Griffiths, T. D. 2020-06-20 doi:10.1101/2020.06.19.161901 Cold Spring Harbor Laboratory Press 2020-06-20 <![CDATA[ Succinate accumulation links mitochondrial MnSOD depletion to aberrant nuclear DNA methylation and altered cell fate ]]> https://biorxiv.org/content/10.1101/2020.06.24.169342v1?rss=1 Cramer-Morales, K. L. Heer, C. D. Mapuskar, K. A. Domann, F. E. 2020-06-24 doi:10.1101/2020.06.24.169342 Cold Spring Harbor Laboratory Press 2020-06-24 <![CDATA[ Recruitment of MRE-11 to complex DNA damage is modulated by meiosis-specific chromosome organization ]]> https://biorxiv.org/content/10.1101/2020.06.26.174573v1?rss=1 Harrell, K. Day, M. Smolikove, S. 2020-06-27 doi:10.1101/2020.06.26.174573 Cold Spring Harbor Laboratory Press 2020-06-27 <![CDATA[ RPA complexes in Caenorhabditis elegans meiosis; unique roles in replication, meiotic recombination and apoptosis ]]> https://biorxiv.org/content/10.1101/2020.06.27.174912v1?rss=1 Hefel, A. Cronin, N. Harrel, K. Patel, P. Spies, M. Smolikove, S. 2020-06-28 doi:10.1101/2020.06.27.174912 Cold Spring Harbor Laboratory Press 2020-06-28 <![CDATA[ Post-ictal generalized EEG suppression and seizure-induced mortality are reduced by enhancing dorsal raphe serotonergic neurotransmission ]]> https://biorxiv.org/content/10.1101/2020.06.28.172460v1?rss=1 Petrucci, A. N. Joyal, K. G. Li, R. Chou, J. W. Vencer, K. M. Buchanan, G. F. 2020-06-29 doi:10.1101/2020.06.28.172460 Cold Spring Harbor Laboratory Press 2020-06-29 <![CDATA[ Unique actions of GABA arising from cytoplasmic chloride microdomains ]]> https://biorxiv.org/content/10.1101/2020.06.29.178160v1?rss=1 Rahmati, N. Normoyle, K. P. Glykys, J. Dzhala, V. I. Lillis, K. P. Kahle, K. T. Raiyyani, R. Jacob, T. Staley, K. J. 2020-06-29 doi:10.1101/2020.06.29.178160 Cold Spring Harbor Laboratory Press 2020-06-29 <![CDATA[ Correlating cell function and morphology by performing fluorescent immunocytochemical staining on the light-microscope stage ]]> https://biorxiv.org/content/10.1101/2020.06.30.180810v1?rss=1 Kawano, H. Kakazu, Y. Iwabuchi, S. Harata, N. C. 2020-07-02 doi:10.1101/2020.06.30.180810 Cold Spring Harbor Laboratory Press 2020-07-02 <![CDATA[ Profiling the Intratumoral Immune Landscapes of Primary and Syngeneic Kras-driven Sarcoma Mouse Models ]]> https://biorxiv.org/content/10.1101/2020.07.01.181263v1?rss=1 Gutierrez, W. R. Scherer, A. McGivney, G. R. Knepper-Adrian, V. Laverty, E. A. Roughton, G. Dodd, R. D. 2020-07-02 doi:10.1101/2020.07.01.181263 Cold Spring Harbor Laboratory Press 2020-07-02 <![CDATA[ Inhibitory ultrapotent chemogenetics activate dopamine D1 receptor-expressing medium spiny neurons ]]> https://biorxiv.org/content/10.1101/2020.07.01.181925v1?rss=1 Gantz, S. C. Ortiz, M. M. Belilos, A. J. Moussawi, K. 2020-07-01 doi:10.1101/2020.07.01.181925 Cold Spring Harbor Laboratory Press 2020-07-01 <![CDATA[ Connectivity patterns of task-specific brain networks allow individual prediction of cognitive symptom dimension of schizophrenia and link to molecular architecture ]]> https://biorxiv.org/content/10.1101/2020.07.02.185124v1?rss=1 Chen, J. Mueller, V. I. Dukart, J. Hoffstaedter, F. Baker, J. T. Holmes, A. J. Vatansever, D. Nickl-Jockschat, T. Liu, X. Derntl, B. Kogler, L. Jardri, R. Gruber, O. Aleman, A. Sommer, I. E. Eickhoff, S. B. Patil, K. R. 2020-07-02 doi:10.1101/2020.07.02.185124 Cold Spring Harbor Laboratory Press 2020-07-02 <![CDATA[ Neurofeedback Training of Auditory Selective Attention Enhances Speech-in-noise Perception ]]> https://biorxiv.org/content/10.1101/2020.07.04.188045v1?rss=1 Kim, S. Emory, C. Choi, I. 2020-07-04 doi:10.1101/2020.07.04.188045 Cold Spring Harbor Laboratory Press 2020-07-04 <![CDATA[ Genetic variation in anesthesia success in a New Zealand freshwater snail ]]> https://biorxiv.org/content/10.1101/2020.07.09.194050v1?rss=1 Qiudong Song Richard Magnuson Marissa Roseman Joseph Jalinsky Maurine Neiman 2020-07-10 doi:10.1101/2020.07.09.194050 Cold Spring Harbor Laboratory Press 2020-07-10 <![CDATA[ Switch-like control of helicase processivity by single-stranded DNA binding protein ]]> https://biorxiv.org/content/10.1101/2020.07.09.194779v1?rss=1 Barbara Stekas Masayoshi Honda Maria Spies Yann R. Chemla 2020-07-09 doi:10.1101/2020.07.09.194779 Cold Spring Harbor Laboratory Press 2020-07-09 <![CDATA[ The Ndr/LATS kinase Cbk1 regulates a specific subset of Ace2 functions and suppresses the hyphae-to-yeast transition in Candida albicans ]]> https://biorxiv.org/content/10.1101/2020.07.10.198242v1?rss=1 Rohan S Wakade Laura C Ristow Mark A Stamnes Anuj Kumar Damian J Krysan 2020-07-11 doi:10.1101/2020.07.10.198242 Cold Spring Harbor Laboratory Press 2020-07-11 <![CDATA[ MITF reprograms the extracellular matrix and focal adhesion in melanoma ]]> https://biorxiv.org/content/10.1101/2020.07.14.202291v1?rss=1 Dilshat, R. Fock, V. Kenny, C. Gerritsen, I. Lasseur, R. M. J. Eichhoff, O. Travnickova, J. Cerny, P. Moller, K. Sigurbjornsdottir, S. Kirty, K. Einarsdottir, B. O. Cheng, P. F. Levesque, M. Cornell, R. Patton, E. E. Larue, L. de Tayrac, M. Magnusdottir, E. Ogmundsdottir, M. H. Steingrimsson, E. 2020-07-15 doi:10.1101/2020.07.14.202291 Cold Spring Harbor Laboratory Press 2020-07-15 <![CDATA[ Lysozyme resistance in C. difficile is dependent on two peptidoglycan deacetylases ]]> https://biorxiv.org/content/10.1101/2020.07.17.209676v1?rss=1 Kaus, G. M. Snyder, L. F. Muh, U. Flores, M. J. Popham, D. L. Ellermeier, C. D. 2020-07-18 doi:10.1101/2020.07.17.209676 Cold Spring Harbor Laboratory Press 2020-07-18 <![CDATA[ Cancer cells are uniquely susceptible to accumulation of MMBIR mutations ]]> https://biorxiv.org/content/10.1101/2020.07.19.209445v1?rss=1 Osia, B. A. Alsulaiman, T. Jackson, T. Kramara, J. Oliveira, S. Malkova, A. 2020-07-19 doi:10.1101/2020.07.19.209445 Cold Spring Harbor Laboratory Press 2020-07-19 <![CDATA[ β-Coronaviruses use lysosomal organelles for cellular egress. ]]> https://biorxiv.org/content/10.1101/2020.07.25.192310v1?rss=1 Altan-Bonnet, N. Altan-Bonnet, G. Y. Ghosh, S. Dellibovi-Ragheb, T. Pak, E. Qiu, Q. Fisher, M. Takvorian, P. Bleck, C. Hsu, V. Fehr, A. Perlman, S. Straus, M. Whittaker, G. de Haan, C. A. 2020-07-25 doi:10.1101/2020.07.25.192310 Cold Spring Harbor Laboratory Press 2020-07-25 <![CDATA[ Bro1 directly stimulates Vps4 activity to promote Intralumenal Vesicle Formation during Multivesicular Body biogenesis ]]> https://biorxiv.org/content/10.1101/2020.07.27.223255v1?rss=1 Katzmann, D. Tseng, C.-c. Dean, S. Davies, B. A. Azmi, I. F. Pashkova, N. Payne, J. A. Staffenhagen, J. West, M. Piper, R. C. Odorizzi, G. 2020-07-28 doi:10.1101/2020.07.27.223255 Cold Spring Harbor Laboratory Press 2020-07-28 <![CDATA[ Biallelic mutation of CLRN2 causes non-syndromic hearing loss in humans ]]> https://biorxiv.org/content/10.1101/2020.07.29.222828v1?rss=1 A, NM_001079827.2) segregating with the disease. Using in vitro RNA splicing analysis, we show that the CLRN2 c.494C>A mutation leads to two events: 1) the substitution of a highly conserved threonine (uncharged amino acid) to lysine (charged amino acid) at position 165, p.(Thr165Lys), and 2) aberrant splicing, with the retention of intron 2 resulting in a stop codon after 26 additional amino acids, p.(Gly146Lysfs*26). Expression studies and phenotyping of newly produced zebrafish and mouse models deficient for clarin 2 further confirm that clarin 2, expressed in the inner ear hair cells, is essential for normal organization and maintenance of the auditory hair bundles, and for hearing function. Together, our findings identify CLRN2 as a new deafness gene, which will impact future diagnosis and treatment for deaf patients. ]]> Vona, B. Mazaheri, N. Lin, S.-J. Dunbar, L. A. Maroofian, R. Azaiez, H. Booth, K. T. Vitry, S. Rad, A. Varshney, P. Fowler, B. Alagramam, K. N. Murphy, D. Shariati, G. Sedaghat, A. Houlden, H. VijayKumar, S. Smith, R. J. H. Haaf, T. El-Amraoui, A. Bowl, M. R. Varshney, G. K. Galehdari, H. 2020-07-29 doi:10.1101/2020.07.29.222828 Cold Spring Harbor Laboratory Press 2020-07-29 <![CDATA[ Impact of low-frequency coding variants on human facial shape ]]> https://biorxiv.org/content/10.1101/2020.07.30.227769v1?rss=1 Liu, D. Alhazmi, N. Matthews, H. Lee, M. K. Li, J. Hecht, J. T. Wehby, G. L. Moreno, L. M. Heike, C. L. Roosenboom, J. Feingold, E. Marazita, M. L. Claes, P. Liao, E. C. Weinberg, S. M. Shaffer, J. R. 2020-07-30 doi:10.1101/2020.07.30.227769 Cold Spring Harbor Laboratory Press 2020-07-30 <![CDATA[ The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS-mTOR signaling and vascular function ]]> https://biorxiv.org/content/10.1101/2020.08.04.236182v1?rss=1 Alghanem, A. F. Ta, C. Maurer, J. M. Gunasekar, S. K. Kumar, A. Fatima, U. Kang, C. Xie, L. Adeola, O. Abello, J. Riker, M. Elliot-Hudson, M. Minerath, R. A. Stratman, A. Grueter, C. E. Mullins, R. F. Sah, R. 2020-08-04 doi:10.1101/2020.08.04.236182 Cold Spring Harbor Laboratory Press 2020-08-04 <![CDATA[ A novel method for tri-clustering dynamic functional network connectivity (dFNC) identifies significant schizophrenia effects across multiple states in distinct subgroups of individuals ]]> https://biorxiv.org/content/10.1101/2020.08.06.239152v1?rss=1 Rahaman, M. A. Damaraju, E. Turner, J. van Erp, T. G. M. Mathalon, D. Vaidya, J. Muller, B. Pearlson, G. D. Calhoun, V. D. 2020-08-07 doi:10.1101/2020.08.06.239152 Cold Spring Harbor Laboratory Press 2020-08-07 <![CDATA[ K18-hACE2 Mice for Studies of COVID-19 Treatments and Pathogenesis Including Anosmia ]]> https://biorxiv.org/content/10.1101/2020.08.07.242073v1?rss=1 Perlman, S. Zheng, J. WONG, L. Y. R. Li, K. Verma, A. K. Ortiz Bezara, M. E. Wohlford-Lenane, C. Leidinger, M. R. Kundson, M. C. Meyerholz, D. K. McCray, P. B. 2020-08-10 doi:10.1101/2020.08.07.242073 Cold Spring Harbor Laboratory Press 2020-08-10 <![CDATA[ Deletion of the voltage-gated calcium channel, CaV1.3, causes deficits in motor performance and associative learning ]]> https://biorxiv.org/content/10.1101/2020.08.12.248120v1?rss=1 Lauffer, M. Wen, H. Myers, B. Plumb, A. Parker, K. L. Williams, A. J. 2020-08-12 doi:10.1101/2020.08.12.248120 Cold Spring Harbor Laboratory Press 2020-08-12 <![CDATA[ Matching a snail's pace: Successful use of environmental DNA techniques to detect early stages of invasion by the destructive New Zealand mud snail ]]> https://biorxiv.org/content/10.1101/2020.08.12.248948v1?rss=1 Woodell, J. D. Neiman, M. Levri, E. P. 2020-08-14 doi:10.1101/2020.08.12.248948 Cold Spring Harbor Laboratory Press 2020-08-14 <![CDATA[ Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders ]]> https://biorxiv.org/content/10.1101/2020.08.13.249813v1?rss=1 Blokland, G. A. Grove, J. Chen, C.-Y. Cotsapas, C. Tobet, S. Handa, R. Schizophrenia Working Group of the Psychiatric Genomics Consortium, St Clair, D. Lencz, T. Mowry, B. J. Periyasamy, S. Cairns, M. J. Tooney, P. A. Wu, J. Q. Kelly, B. Kirov, G. Sullivan, P. F. Corvin, A. Riley, B. P. Esko, T. Milani, L. Jönsson, E. G. Palotie, A. Ehrenreich, H. Begemann, M. Steixner-Kumar, A. Sham, P. C. Iwata, N. Weinberger, D. R. Gejman, P. V. Sanders, A. R. Buxbaum, J. D. Rujescu, D. Giegling, I. Konte, B. Hartmann, A. M. Bramon, E. Murray, R. M. Pato, M. T. Lee, 2020-08-17 doi:10.1101/2020.08.13.249813 Cold Spring Harbor Laboratory Press 2020-08-17 <![CDATA[ Aging-vulnerable and -resilient trajectories of specific motor circuit function in oxidation- and temperature-stressed Drosophila ]]> https://biorxiv.org/content/10.1101/2020.08.19.257832v1?rss=1 Iyengar, A. Ruan, H. Wu, C.-F. 2020-08-20 doi:10.1101/2020.08.19.257832 Cold Spring Harbor Laboratory Press 2020-08-20 <![CDATA[ TMS bursts can modulate local and networks oscillations during lower-limb movement in elderly subjects ]]> https://biorxiv.org/content/10.1101/2020.08.19.257980v1?rss=1 Espinoza, A. I. Scholl, J. L. Singh, A. 2020-08-20 doi:10.1101/2020.08.19.257980 Cold Spring Harbor Laboratory Press 2020-08-20 <![CDATA[ PACAP induces light aversion in mice by an inheritable mechanism independent of CGRP ]]> https://biorxiv.org/content/10.1101/2020.08.20.255968v1?rss=1 Kuburas, A. Mason, B. N. Hing, B. Reis, A. S. Sowers, L. P. Moldovan Loomis, C. Garcia-Martinez, L. F. Russo, A. F. 2020-08-20 doi:10.1101/2020.08.20.255968 Cold Spring Harbor Laboratory Press 2020-08-20 <![CDATA[ Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma ]]> https://biorxiv.org/content/10.1101/2020.08.24.265140v1?rss=1 Campbell, N. R. Rao, A. Zhang, X. Baron, M. Heilmann, S. Deforet, M. Kenny, C. Ferretti, L. Huang, T.-H. Garg, M. Nsengimana, J. Montal, E. Tagore, M. Hunter, M. Newton-Bishop, J. Middleton, M. Corrie, P. Adams, D. Rabbie, R. Levesque, M. Cornell, R. Yanai, I. Xavier, J. White, R. 2020-08-24 doi:10.1101/2020.08.24.265140 Cold Spring Harbor Laboratory Press 2020-08-24 <![CDATA[ Click evoked Middle Ear Muscle Reflex: Implications for Medial Olivocochlear System Assays ]]> https://biorxiv.org/content/10.1101/2020.08.24.265462v1?rss=1 Boothalingam, S. Goodman, S. S. 2020-08-25 doi:10.1101/2020.08.24.265462 Cold Spring Harbor Laboratory Press 2020-08-25 <![CDATA[ Long Period Modeling SARS-CoV-2 Infection of in Vitro Cultured Polarized Human Airway Epithelium ]]> https://biorxiv.org/content/10.1101/2020.08.27.271130v1?rss=1 Hao, S. Ning, K. Kuz, C. A. Vorhies, K. Yan, Z. Qiu, J. 2020-08-28 doi:10.1101/2020.08.27.271130 Cold Spring Harbor Laboratory Press 2020-08-28 <![CDATA[ gEAR: gene Expression Analysis Resource portal for community-driven, multi-omic data exploration ]]> https://biorxiv.org/content/10.1101/2020.08.28.272039v1?rss=1 Orvis, J. Gottfried, B. Kancherla, J. Adkins, R. S. Song, Y. Dror, A. A. Olley, D. Rose, K. Chrysostomou, E. Kelley, M. C. Milon, B. Matern, M. S. Azaiez, H. Herb, B. Colantuoni, C. Carter, R. L. Ament, S. A. Kelley, M. W. White, O. Bravo, H. C. Mahurkar, A. Hertzano, R. 2020-08-31 doi:10.1101/2020.08.28.272039 Cold Spring Harbor Laboratory Press 2020-08-31 <![CDATA[ TAZ-CAMTA1 and YAP-TFE3 modulate the basal TAZ/YAP transcriptional program by recruiting the ATAC histone acetyltransferase complex ]]> https://biorxiv.org/content/10.1101/2020.09.07.286633v1?rss=1 Merritt, N. Garcia, K. Rajendran, D. Lin, Z.-Y. Zhang, X. Mitchell, K. Borcherding, N. Fullenkamp, C. Chimenti, M. Gingras, A.-C. Harvey, K. Tanas, M. R. 2020-09-08 doi:10.1101/2020.09.07.286633 Cold Spring Harbor Laboratory Press 2020-09-08 <![CDATA[ Glypican4 mediates Wnt transport between germ layers via signaling filopodia ]]> https://biorxiv.org/content/10.1101/2020.09.08.288613v1?rss=1 Hu, B. Kakkerla Balaraju, A. Rodriguez, J. J. Gao, Y. Nguyen, N. T. Steen, H. Suhaib, S. Chen, S. Lin, F. 2020-09-09 doi:10.1101/2020.09.08.288613 Cold Spring Harbor Laboratory Press 2020-09-09 <![CDATA[ Latency and amplitude of the stop-signal P3 event-related potential are related to inhibitory GABAa activity in primary motor cortex ]]> https://biorxiv.org/content/10.1101/2020.09.15.298711v1?rss=1 Hynd, M. Soh, C. Rangel, B. Wessel, J. R. 2020-09-16 doi:10.1101/2020.09.15.298711 Cold Spring Harbor Laboratory Press 2020-09-16 <![CDATA[ Multivariate GWAS elucidates the genetic architecture of alcohol consumption and misuse, corrects biases, and reveals novel associations with disease ]]> https://biorxiv.org/content/10.1101/2020.09.21.304196v1?rss=1 Mallard, T. T. Savage, J. E. Johnson, E. C. Huang, Y. Edwards, A. C. Hottenga, J. J. Grotzinger, A. D. Gustavson, D. E. Jennings, M. V. Anokhin, A. Dick, D. M. Edenberg, H. J. Kramer, J. R. Lai, D. Meyers, J. L. Pandey, A. K. Harden, K. P. Nivard, M. G. de Geus, E. J. Boomsma, D. I. Agrawal, A. Davis, L. K. Clarke, T.-K. Palmer, A. A. Sanchez-Roige, S. 2020-09-22 doi:10.1101/2020.09.21.304196 Cold Spring Harbor Laboratory Press 2020-09-22 <![CDATA[ CREB is Required in Excitatory Neurons in the Forebrain to Sustain Wakefulness ]]> https://biorxiv.org/content/10.1101/2020.09.22.308403v1?rss=1 Wimmer, M. Cui, R. Blackwell, J. Abel, T. 2020-09-22 doi:10.1101/2020.09.22.308403 Cold Spring Harbor Laboratory Press 2020-09-22 <![CDATA[ The Maintenance of Muscle Mass Is Independent of Testosterone in Adult Male Mice ]]> https://biorxiv.org/content/10.1101/2020.09.24.311266v1?rss=1 Davidyan, A. Baar, K. Bodine, S. C. 2020-09-24 doi:10.1101/2020.09.24.311266 Cold Spring Harbor Laboratory Press 2020-09-24 <![CDATA[ CARMIL3 is important for cell migration and morphogenesis during early development in zebrafish ]]> https://biorxiv.org/content/10.1101/2020.09.27.315655v1?rss=1 Stark, B. C. Gao, Y. Belk, L. Culver, M. A. Hu, B. Sepich, D. S. Mekel, M. Solnica-Krezel, L. Lin, F. Cooper, J. 2020-09-27 doi:10.1101/2020.09.27.315655 Cold Spring Harbor Laboratory Press 2020-09-27 <![CDATA[ Consolidation and maintenance of Drosophila long-term memory require LIM homeodomain protein Apterous in distinct brain neurons ]]> https://biorxiv.org/content/10.1101/2020.09.29.319715v1?rss=1 Inami, S. Sato, T. Suzuki, Y. Kitamoto, T. Sakai, T. 2020-10-01 doi:10.1101/2020.09.29.319715 Cold Spring Harbor Laboratory Press 2020-10-01 <![CDATA[ Perilipin2 down-regulation in beta cells impairs insulin secretion under nutritional stress and damages mitochondria ]]> https://biorxiv.org/content/10.1101/2020.10.01.322974v1?rss=1 Mishra, A. Liu, S. Promes, J. Harata, M. Sivitz, W. Fink, B. Bhardwaj, G. O'Neill, B. Kang, C. Sah, R. Strack, S. Stephens, S. King, T. Jackson, L. Greenberg, A. Anokye-Danso, F. Ahima, R. Ankrum, J. A. Imai, Y. 2020-10-01 doi:10.1101/2020.10.01.322974 Cold Spring Harbor Laboratory Press 2020-10-01 <![CDATA[ The X-linked intellectual disability gene product and E3 ubiquitin ligase KLHL15 degrades doublecortin proteins to constrain neuronal dendritogenesis ]]> https://biorxiv.org/content/10.1101/2020.10.02.324285v1?rss=1 Song, J. Merrill, R. A. Usachev, A. Y. Strack, S. 2020-10-02 doi:10.1101/2020.10.02.324285 Cold Spring Harbor Laboratory Press 2020-10-02 <![CDATA[ Dimerization of a membrane transporter is driven by differential energetics of lipid solvation of dissociated and associated states ]]> https://biorxiv.org/content/10.1101/2020.10.05.327239v1?rss=1 Chadda, R. Bernhardt, N. Kelley, E. G. Teixeira, S. C. M. Griffith, K. Gil-Ley, A. Ozturk, T. N. Hughes, L. E. Forsythe, A. Krishnamani, V. Faraldo-Gomez, J. Robertson, J. L. 2020-10-07 doi:10.1101/2020.10.05.327239 Cold Spring Harbor Laboratory Press 2020-10-07 <![CDATA[ A mouse model of Bardet-Biedl Syndrome has impaired fear memory, which is rescued by lithium treatment ]]> https://biorxiv.org/content/10.1101/2020.10.06.322883v1?rss=1 Pak, T. K. Carter, C. S. Zhang, Q. Huang, S. C. Searby, C. Hsu, Y. Taugher, R. Vogel, T. Cychosz, C. C. Genova, R. Moreira, N. Stevens, H. Wemmie, J. Pieper, A. A. Wang, K. K. Sheffield, V. C. 2020-10-07 doi:10.1101/2020.10.06.322883 Cold Spring Harbor Laboratory Press 2020-10-07 <![CDATA[ Accelerated erythrocyte senescence causes dose-limiting anemia of antimalarial enolase inhibitors ]]> https://biorxiv.org/content/10.1101/2020.10.09.331728v1?rss=1 Jezewski, A. J. Lin, Y.-H. Reisz, J. A. Culp-Hill, R. Barekatain, Y. Yan, V. C. D'Alessandro, A. Muller, F. L. Odom John, A. R. 2020-10-10 doi:10.1101/2020.10.09.331728 Cold Spring Harbor Laboratory Press 2020-10-10 <![CDATA[ A class of synaptic signaling molecules required for homeostatic potentiation also tunes homeostatic depression ]]> https://biorxiv.org/content/10.1101/2020.10.12.336883v1?rss=1 Yeates, C. J. Frank, C. A. 2020-10-13 doi:10.1101/2020.10.12.336883 Cold Spring Harbor Laboratory Press 2020-10-13 <![CDATA[ Phylogeny, morphology, and ecology resurrect previously synonymized species of North American Stereum ]]> https://biorxiv.org/content/10.1101/2020.10.16.342840v1?rss=1 DeLong-Duhon, S. G. Bagley, R. K. 2020-10-16 doi:10.1101/2020.10.16.342840 Cold Spring Harbor Laboratory Press 2020-10-16 <![CDATA[ Lentiviral vectors transduce lung stem cells without disrupting plasticity ]]> https://biorxiv.org/content/10.1101/2020.10.19.345611v1?rss=1 Cooney, A. L. Thurman, A. L. McCray, P. B. Pezzulo, A. A. Sinn, P. L. 2020-10-19 doi:10.1101/2020.10.19.345611 Cold Spring Harbor Laboratory Press 2020-10-19 <![CDATA[ The impact of life stage and pigment source on the evolution of novel warning signal traits ]]> https://biorxiv.org/content/10.1101/2020.10.20.346700v1?rss=1 Lindstedt, C. Bagley, R. K. Calhim, S. Jones, M. Linnen, C. R. 2020-10-21 doi:10.1101/2020.10.20.346700 Cold Spring Harbor Laboratory Press 2020-10-21 <![CDATA[ Timing variability and midfrontal ~4 Hz rhythms correlate with cognition in Parkinson's disease ]]> https://biorxiv.org/content/10.1101/2020.10.26.356154v1?rss=1 Singh, A. Cole, R. Espinoza, A. I. Evans, A. Cao, S. Cavanagh, J. F. Narayanan, N. S. 2020-10-27 doi:10.1101/2020.10.26.356154 Cold Spring Harbor Laboratory Press 2020-10-27 <![CDATA[ The fusion peptide proximal region of the HIV-1 envelope glycoproteins regulates exposure of immunogenic epitopes at the trimer base ]]> https://biorxiv.org/content/10.1101/2020.10.28.360131v1?rss=1 Rojas Chavez, A. R. Boyt, D. Han, C. Wu, L. Haim, H. 2020-10-29 doi:10.1101/2020.10.28.360131 Cold Spring Harbor Laboratory Press 2020-10-29 <![CDATA[ N6-methyladenosine modification of HIV-1 RNA evades RIG-I-mediated sensing to suppresses type-I interferon induction in monocytic cells ]]> https://biorxiv.org/content/10.1101/2020.11.04.368712v1?rss=1 Chen, S. Kumar, S. Tirumuru, N. Welch, J. L. Hu, L. He, C. Stapleton, J. T. Wu, L. 2020-11-04 doi:10.1101/2020.11.04.368712 Cold Spring Harbor Laboratory Press 2020-11-04 <![CDATA[ TRAF6 and TAK1 contribute to SAMHD1-mediated negative regulation of NF-kB signaling ]]> https://biorxiv.org/content/10.1101/2020.11.07.368704v1?rss=1 Espada, C. E. St. Gelais, C. Bonifati, S. Maksimova, V. V. Cahill, M. P. Kim, S. H. Wu, L. 2020-11-07 doi:10.1101/2020.11.07.368704 Cold Spring Harbor Laboratory Press 2020-11-07 <![CDATA[ The Development of a Novel Nanobody Therapeutic for SARS-CoV-2 ]]> https://biorxiv.org/content/10.1101/2020.11.17.386532v1?rss=1 Ye, G. Gallant, J. Massey, C. Shi, K. Tai, W. Zheng, J. Odle, A. Vickers, M. Shang, J. Wan, Y. Drelich, A. Kempaiah, K. Tat, V. Perlman, S. Du, L. Tseng, C.-T. Aihara, H. LeBeau, A. Li, F. 2020-11-17 doi:10.1101/2020.11.17.386532 Cold Spring Harbor Laboratory Press 2020-11-17 <![CDATA[ Representations of local spatial information in the human medial temporal lobe duringmemory-guided navigation ]]> https://biorxiv.org/content/10.1101/2020.11.18.389346v1?rss=1 Wang, S.-F. Carr, V. A. Favila, S. E. Bailenson, J. N. Brown, T. I. Jiang, J. Wagner, A. D. 2020-11-19 doi:10.1101/2020.11.18.389346 Cold Spring Harbor Laboratory Press 2020-11-19 <![CDATA[ Enhanced virus detection and metagenomic sequencing in patients with meningitis and encephalitis ]]> https://biorxiv.org/content/10.1101/2020.11.25.399394v1?rss=1 Piantadosi, A. Mukerji, S. S. Ye, S. Leone, M. J. Freimark, L. Park, D. J. Adams, G. Lemieux, J. Kanjilal, S. Solomon, I. H. Ahmed, A. A. Goldstein, R. Ganesh, V. Ostrem, B. Cummins, K. C. Thon, J. Kinsella, C. M. Rosenberg, E. S. Frosh, M. P. Goldberg, M. B. Cho, T. Sabeti, P. 2020-11-27 doi:10.1101/2020.11.25.399394 Cold Spring Harbor Laboratory Press 2020-11-27 <![CDATA[ Investigations into modifications of neuromuscular physiology by axonal transport disruptions in Drosophila SOD1 mutants ]]> https://biorxiv.org/content/10.1101/2020.11.27.399956v1?rss=1 O'Harrow, T. C. D. G. Ueda, A. Xing, X. Wu, C.-F. 2020-11-27 doi:10.1101/2020.11.27.399956 Cold Spring Harbor Laboratory Press 2020-11-27 <![CDATA[ Magnetic Tweezers with Magnetic Flux Density Feedback Control ]]> https://biorxiv.org/content/10.1101/2020.12.03.410662v1?rss=1 Moghram, W. I. Kruger, A. Sander, E. A. Selby, J. C. 2020-12-04 doi:10.1101/2020.12.03.410662 Cold Spring Harbor Laboratory Press 2020-12-04 <![CDATA[ Integration of Magnetic Tweezers and Traction Force Microscopy for the Exploration of Matrix Rheology and Keratinocyte Mechanobiology: Model Force- and Displacement-Controlled Experiments ]]> https://biorxiv.org/content/10.1101/2020.12.03.410704v1?rss=1 Moghram, W. I. Singh, P. VandeLune, C. A. Sander, E. A. Selby, J. C. 2020-12-04 doi:10.1101/2020.12.03.410704 Cold Spring Harbor Laboratory Press 2020-12-04 <![CDATA[ Circadian rhythms in bipolar disorder patient-derived neurons predict lithium response ]]> https://biorxiv.org/content/10.1101/2020.12.14.422616v1?rss=1 Mishra, H. K. Ying, N. M. Luis, A. Wei, H. Nguyen, M. Nakhla, T. Vandenburgh, S. Alda, M. Berrettini, W. H. Brennand, K. J. Calabrese, J. R. Coryell, W. H. Frye, M. A. Gage, F. H. Gershon, E. S. McInnis, M. G. Nievergelt, C. M. Nurnberger, J. I. Shilling, P. D. Oedegaard, K. J. Zandi, P. P. The Pharmacogenomics of Bipolar Disorder Study, Kelsoe, J. R. Welsh, D. K. McCarthy, M. J. 2020-12-15 doi:10.1101/2020.12.14.422616 Cold Spring Harbor Laboratory Press 2020-12-15 <![CDATA[ Sensory coding of limb kinematics in developing primary motor cortex ]]> https://biorxiv.org/content/10.1101/2020.12.14.422707v1?rss=1 Glanz, R. M. Dooley, J. C. Sokoloff, G. Blumberg, M. S. 2020-12-14 doi:10.1101/2020.12.14.422707 Cold Spring Harbor Laboratory Press 2020-12-14 <![CDATA[ Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency ]]> https://biorxiv.org/content/10.1101/2020.12.22.423903v1?rss=1 De La Rossa, A. Laporte, M. H. Astori, S. Marissal, T. Montessuit, S. Sheshadri, P. Ramos-Fernández, E. Mendez, P. Khani, A. Quairiaux, C. Taylor, E. Rutter, J. Nunes, J. M. carleton, a. Duchen, M. Sandi, C. Martinou, J.-C. 2020-12-22 doi:10.1101/2020.12.22.423903 Cold Spring Harbor Laboratory Press 2020-12-22 <![CDATA[ Biological Correlations and Confounding Variables for Quantification of Retinal Ganglion Cells Based on Optical Coherence Tomography Using Diversity Outbred Mice ]]> https://biorxiv.org/content/10.1101/2020.12.23.423848v1?rss=1 Hedberg-Buenz, A. Meyer, K. J. van der Heide, C. J. Deng, W. Lee, K. Soukup, D. A. Kettelson, M. Pellack, D. Mercer, H. Wang, K. Garvin, M. K. Abramoff, M. D. Anderson, M. G. 2020-12-23 doi:10.1101/2020.12.23.423848 Cold Spring Harbor Laboratory Press 2020-12-23 <![CDATA[ Genome evolution in a putatively asexual wasp ]]> https://biorxiv.org/content/10.1101/2020.12.23.424202v1?rss=1 Tvedte, E. S. Ward, A. C. Trendle, B. Forbes, A. A. Logsdon, J. M. 2020-12-24 doi:10.1101/2020.12.23.424202 Cold Spring Harbor Laboratory Press 2020-12-24 <![CDATA[ ADH5-mediated NO Bioactivity Maintains Metabolic Homeostasis in Brown Adipose Tissue ]]> https://biorxiv.org/content/10.1101/2020.12.27.424489v1?rss=1 Sebag, S. C. Zhang, Z. Qian, Q. Harata, M. Li, M. Li, W. Zhu, Z. Zingman, L. Liu, L. Lira, V. A. Potthoff, M. J. Bartelt, A. Yang, L. 2020-12-28 doi:10.1101/2020.12.27.424489 Cold Spring Harbor Laboratory Press 2020-12-28 <![CDATA[ Restoration longevity among geriatric and adult special needs patients ]]> https://biorxiv.org/content/10.1101/202069v1?rss=1 Caplan, D. J. Li, Y. Wang, W. Kang, S. Marchini, L. Cowen, H. Yan, J. 2017-10-12 doi:10.1101/202069 Cold Spring Harbor Laboratory Press 2017-10-12 <![CDATA[ OPA1 Deletion in Brown Adipose Tissue Improves Thermoregulation and Systemic Metabolism via FGF21 ]]> https://biorxiv.org/content/10.1101/2021.01.04.425181v1?rss=1 Pereira, R. O. Marti, A. Olvera, A. C. Tadinada, S. M. Bjorkman, S. H. Weatherford, E. T. Westphal, M. Patel, P. H. Kirby, A. K. Hewezi, R. Bui Tran, W. Pena, L. M. G. Souvenir, R. A. Mital, M. Adams, C. M. Potthoff, M. J. Abel, E. D. 2021-01-05 doi:10.1101/2021.01.04.425181 Cold Spring Harbor Laboratory Press 2021-01-05 <![CDATA[ TMPRSS2 structure-phylogeny repositions Avoralstat for SARS-CoV-2 prophylaxis in mice ]]> https://biorxiv.org/content/10.1101/2021.01.04.425289v1?rss=1 Sun, Y. J. Velez, G. Parsons, D. Li, K. Ortiz, M. Sharma, S. McCray, P. B. Bassuk, A. G. Mahajan, V. B. 2021-01-04 doi:10.1101/2021.01.04.425289 Cold Spring Harbor Laboratory Press 2021-01-04 <![CDATA[ KERA: Analysis Tool for Multi-Process, Multi-State Single-Molecule Data ]]> https://biorxiv.org/content/10.1101/2021.01.04.425319v1?rss=1 Tibbs, J. Ghoneim, M. Caldwell, C. C. Buzynski, T. Bowie, W. Boehm, E. M. Washington, M. T. Tabei, S. M. A. Spies, M. 2021-01-05 doi:10.1101/2021.01.04.425319 Cold Spring Harbor Laboratory Press 2021-01-05 <![CDATA[ Dominant and nondominant distal radius microstructure: predictors of asymmetry and effects of a unilateral mechanical loading intervention ]]> https://biorxiv.org/content/10.1101/2021.01.12.426389v1?rss=1 Troy, K. Mancuso, M. Johnson, J. E. Butler, T. A. Ngo, B. H. Schnitzer, T. 2021-01-14 doi:10.1101/2021.01.12.426389 Cold Spring Harbor Laboratory Press 2021-01-14 <![CDATA[ Recombinant adenovirus causes prolonged mobilization of macrophages in the anterior chamber of mice ]]> https://biorxiv.org/content/10.1101/2021.01.13.426423v1?rss=1 Meyer, K. J. Pellack, D. Hedberg-Buenz, A. J. Pomernackas, N. Soukup, D. Wang, K. Fingert, J. H. Anderson, M. G. 2021-01-14 doi:10.1101/2021.01.13.426423 Cold Spring Harbor Laboratory Press 2021-01-14 <![CDATA[ BRN2 is a non-canonical melanoma tumor-suppressor ]]> https://biorxiv.org/content/10.1101/2021.01.13.426554v1?rss=1 Hamm, M. Sohier, P. Petit, V. Raymond, J. Delmas, V. Le Coz, M. Gesbert, F. Kenny, C. Aktary, Z. Pouteaux, M. Rambow, F. Sarasin, A. Bellacosa, A. Sanchez-del-Campo, L. Mosteo, L. Lauss, M. Meijer, D. Steingrimsson, E. Jonsson, G. Cornell, R. Davidson, I. Goding, C. Larue, L. 2021-01-13 doi:10.1101/2021.01.13.426554 Cold Spring Harbor Laboratory Press 2021-01-13 <![CDATA[ A processing pipeline for image reconstructed fNIRS analysis using both MRI templates and individual anatomy ]]> https://biorxiv.org/content/10.1101/2021.01.14.426719v1?rss=1 Forbes, S. H. Wijeakumar, S. Eggebrecht, A. T. Magnotta, V. A. Spencer, J. P. 2021-01-16 doi:10.1101/2021.01.14.426719 Cold Spring Harbor Laboratory Press 2021-01-16 <![CDATA[ Intracranial electrical stimulation alters meso-scale network integration as a function of network topology ]]> https://biorxiv.org/content/10.1101/2021.01.16.426941v1?rss=1 Thompson, W. H. Esteban, O. Oya, H. Nair, R. Eberhardt, F. Dubois, J. Poldrack, R. A. Adolphs, R. Shine, J. M. 2021-01-19 doi:10.1101/2021.01.16.426941 Cold Spring Harbor Laboratory Press 2021-01-19 <![CDATA[ Differential requirement of NPHP1 for compartmentalized protein localization during photoreceptor outer segment development and maintenance ]]> https://biorxiv.org/content/10.1101/2021.01.20.427412v1?rss=1 Datta, P. Cribbs, J. T. Seo, S. 2021-01-20 doi:10.1101/2021.01.20.427412 Cold Spring Harbor Laboratory Press 2021-01-20 <![CDATA[ Rab11a mediates cell-cell spread and reassortment of influenza A virus genomes via tunneling nanotubes. ]]> https://biorxiv.org/content/10.1101/2021.01.20.427426v1?rss=1 Ganti, K. Han, J. Manicassamy, B. Lowen, A. C. 2021-01-20 doi:10.1101/2021.01.20.427426 Cold Spring Harbor Laboratory Press 2021-01-20 <![CDATA[ Performance of a scalable extraction-free RNA-seq method ]]> https://biorxiv.org/content/10.1101/2021.01.22.427817v1?rss=1 Ghimire, S. Stewart, C. G. Thurman, A. L. Pezzulo, A. A. 2021-01-22 doi:10.1101/2021.01.22.427817 Cold Spring Harbor Laboratory Press 2021-01-22 <![CDATA[ L-WNK1 is required for BK channel activation in intercalated cells ]]> https://biorxiv.org/content/10.1101/2021.01.26.428162v1?rss=1 Ray, E. C. Carrisoza, R. Al-Bataineh, M. Marciszyn, A. L. Nkashama, L. Chen, J. C. Winfrey, A. Flores, D. Wu, P. Wang, W. C. wang, c.-l. Subramanya, A. R. Kleyman, T. R. Satlin, L. M. 2021-01-27 doi:10.1101/2021.01.26.428162 Cold Spring Harbor Laboratory Press 2021-01-27 <![CDATA[ Maternal transfer of neutralizing antibodies to OspA after oral vaccination of the rodent reservoir ]]> https://biorxiv.org/content/10.1101/2021.01.27.428441v1?rss=1 O'Connell, K. Nair, N. Samanta, K. Azevedo, J. F. Brown, G. D. Petersen, C. A. Gomes-Solecki, M. 2021-01-27 doi:10.1101/2021.01.27.428441 Cold Spring Harbor Laboratory Press 2021-01-27 <![CDATA[ Altered cleavage of Caspase-1 in hepatocytes limits control of malaria in the liver ]]> https://biorxiv.org/content/10.1101/2021.01.28.427517v1?rss=1 Marques-da-Silva, C. Poudel, B. Baptista, R. P. Peissig, K. Hancox, L. S. Shiau, J. C. Pewe, L. Shears, M. J. Kanneganti, T.-D. Sinnis, P. Kyle, D. E. Gurung, P. Harty, J. T. Kurup, S. P. 2021-01-28 doi:10.1101/2021.01.28.427517 Cold Spring Harbor Laboratory Press 2021-01-28 <![CDATA[ Gene network module changes associated with the vertebrate fin to limb transition ]]> https://biorxiv.org/content/10.1101/2021.01.28.428646v1?rss=1 Fernando, P. C. Mabee, P. M. Zeng, E. 2021-01-29 doi:10.1101/2021.01.28.428646 Cold Spring Harbor Laboratory Press 2021-01-29 <![CDATA[ MTHFD2 is a Metabolic Checkpoint Controlling Effector and Regulatory T Cell Fate and Function ]]> https://biorxiv.org/content/10.1101/2021.02.03.428939v1?rss=1 Sugiura, A. Andrejeva, G. Voss, K. Heintzman, D. R. Beier, K. L. Wolf, M. M. Greenwood, D. L. Ye, X. Shahi, S. K. Freedman, S. N. Cameron, A. M. Foerch, P. Bourne, T. Xu, X. Garcia-Canaveras, J. C. Mangalam, A. K. Rabinowitz, J. Rathmell, J. 2021-02-03 doi:10.1101/2021.02.03.428939 Cold Spring Harbor Laboratory Press 2021-02-03 <![CDATA[ The SARS-CoV-2 transcriptome and the dynamics of the S gene furin cleavage site in primary human airway epithelia ]]> https://biorxiv.org/content/10.1101/2021.02.03.429670v1?rss=1 Zou, W. Xiong, M. Hao, S. Zhang-Chen, E. Y. Baumlin, N. Kim, M. D. Salathe, M. Yan, Z. Qiu, J. 2021-02-04 doi:10.1101/2021.02.03.429670 Cold Spring Harbor Laboratory Press 2021-02-04 <![CDATA[ Post-infection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection ]]> https://biorxiv.org/content/10.1101/2021.02.05.429937v1?rss=1 Dampalla, C. Zheng, J. Perera, K. Wong, L. Y. R. Meyerholz, D. Nguyen, H. Kashipathy, M. Battaile, K. Lovell, S. Kim, Y. Perlman, S. Groutas, W. Chang, K.-O. 2021-02-05 doi:10.1101/2021.02.05.429937 Cold Spring Harbor Laboratory Press 2021-02-05 <![CDATA[ Cortico-subcortical β burst dynamics underlying movement cancellation in humans ]]> https://biorxiv.org/content/10.1101/2021.02.06.430074v1?rss=1 Diesburg, D. A. Greenlee, J. D. W. Wessel, J. R. 2021-02-07 doi:10.1101/2021.02.06.430074 Cold Spring Harbor Laboratory Press 2021-02-07 <![CDATA[ Impact of Binge Drinking During College on Resting State Functional Connectivity ]]> https://biorxiv.org/content/10.1101/2021.02.09.430381v1?rss=1 Tong, T. T. Vaidya, J. G. Kramer, J. R. Kuperman, S. Langbehn, D. R. OLeary, D. S. 2021-02-15 doi:10.1101/2021.02.09.430381 Cold Spring Harbor Laboratory Press 2021-02-15 <![CDATA[ Cardiac Specific Overexpression of Transcription Factor EB (TFEB) in Normal Hearts Induces Pathologic Cardiac Hypertrophy and Lethal Cardiomyopathy ]]> https://biorxiv.org/content/10.1101/2021.02.16.431474v1?rss=1 Kenny, H. C. Weatherford, E. T. Collins, G. V. Allamargot, C. Gesalla, T. Zimmerman, K. Goel, H. McLendon, J. M. Dai, D.-F. Romac, T. Streeter, J. Abhinav, D. Pereira, R. O. Sharafuddin, J. Song, L.-S. Abel, E. D. C. 2021-02-17 doi:10.1101/2021.02.16.431474 Cold Spring Harbor Laboratory Press 2021-02-17 <![CDATA[ Twitches emerge postnatally during quiet sleep in human infants and are synchronized with sleep spindles ]]> https://biorxiv.org/content/10.1101/2021.02.17.431688v1?rss=1 Sokoloff, G. Dooley, J. C. Glanz, R. M. Wen, R. Y. Hickerson, M. M. Evans, L. G. Laughlin, H. M. Apfelbaum, K. S. Blumberg, M. S. 2021-02-18 doi:10.1101/2021.02.17.431688 Cold Spring Harbor Laboratory Press 2021-02-18 <![CDATA[ RELATIONSHIP BETWEEN PARENTAL AGE AND SEVERITY OF OROFACIAL CLEFTS ]]> https://biorxiv.org/content/10.1101/2021.02.22.432246v1?rss=1 Adamson, O. O. Oladugba, A. Alade, A. Awotoye, W. Busch, T. Li, M. Fashina, A. Olotu, J. Sule, V. James, O. Ogunlewe, M. Adeyemo, W. Butali, A. 2021-02-22 doi:10.1101/2021.02.22.432246 Cold Spring Harbor Laboratory Press 2021-02-22 <![CDATA[ Germline activity of the heat shock factor HSF-1 programs the insulin-receptor daf-2 in C. elegans ]]> https://biorxiv.org/content/10.1101/2021.02.22.432344v1?rss=1 Prahlad, V. Das, S. Min, S. 2021-02-22 doi:10.1101/2021.02.22.432344 Cold Spring Harbor Laboratory Press 2021-02-22 <![CDATA[ Ovarian Tumor Mitochondria Exhibit Abnormal Phenotypes and Blunted Associations with Biobehavioral Factors ]]> https://biorxiv.org/content/10.1101/2021.02.26.432917v1?rss=1 Bindra, S. McGill, M. A. Triplett, M. K. Tyagi, A. Thaker, P. H. Dahmoush, L. Goodheart, M. J. Ogden, T. Owusu-Ansah, E. Karan, K. Cole, S. Sood, A. K. Lutgendorf, S. K. Picard, M. 2021-02-26 doi:10.1101/2021.02.26.432917 Cold Spring Harbor Laboratory Press 2021-02-26 <![CDATA[ Towards a two-stage model of action-stopping: Attentional capture explains motor inhibition during early stop-signal processing ]]> https://biorxiv.org/content/10.1101/2021.02.26.433098v1?rss=1 Tatz, J. Soh, C. Wessel, J. R. 2021-02-27 doi:10.1101/2021.02.26.433098 Cold Spring Harbor Laboratory Press 2021-02-27 <![CDATA[ Small molecule SWELL1-LRRC8 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes ]]> https://biorxiv.org/content/10.1101/2021.02.28.432901v1?rss=1 Gunasekar, S. K. Xie, L. Chheda, P. R. Kang, C. Kern, D. M. My-Ta, C. Kumar, A. Maurer, J. M. Gerber, E. E. Grzesik, W. J. Elliot-Hudson, M. Zhang, Y. Kulkarni, C. A. Samuel, I. Smith, J. K. Nau, P. Imai, Y. Sheldon, R. D. Taylor, E. B. Lerner, D. J. Norris, A. W. Brohawn, S. G. Kerns, R. Sah, R. 2021-03-02 doi:10.1101/2021.02.28.432901 Cold Spring Harbor Laboratory Press 2021-03-02 <![CDATA[ Neuroanatomical organization and functional roles of PVN MC4R pathways in physiological and behavioral regulations ]]> https://biorxiv.org/content/10.1101/2021.03.08.431341v1?rss=1 Cui, H. Singh, U. Saito, K. Toth, B. A. Dickey, J. E. Rodeghiero, S. R. Deng, Y. Deng, g. Xue, B. Zhu, Z. Jiang, J. Zingman, L. V. 2021-03-09 doi:10.1101/2021.03.08.431341 Cold Spring Harbor Laboratory Press 2021-03-09 <![CDATA[ Differential effects on neuromuscular physiology between Sod loss-of-function mutation and paraquat-induced oxidative stress in Drosophila ]]> https://biorxiv.org/content/10.1101/2021.03.08.434419v1?rss=1 Ueda, A. Iyengar, A. Wu, C.-F. 2021-03-08 doi:10.1101/2021.03.08.434419 Cold Spring Harbor Laboratory Press 2021-03-08 <![CDATA[ Measles virus exits human airway epithelia via infectious center sloughing ]]> https://biorxiv.org/content/10.1101/2021.03.09.434554v1?rss=1 Hippee, C. Singh, B. Thurman, A. Cooney, A. Pezzulo, A. Cattaneo, R. Sinn, P. L. 2021-03-09 doi:10.1101/2021.03.09.434554 Cold Spring Harbor Laboratory Press 2021-03-09 <![CDATA[ Interaction of micropatterned topographical and biochemical cues to direct neurite growth from spiral ganglion neurons ]]> https://biorxiv.org/content/10.1101/2021.03.10.434606v1?rss=1 Truong, K. Leigh, B. Vecchi, J. T. Bartholomew, R. Xu, L. Guymon, C. A. Hansen, M. R. 2021-03-12 doi:10.1101/2021.03.10.434606 Cold Spring Harbor Laboratory Press 2021-03-12 <![CDATA[ Bi-directional flow of the funny current (If) during the pacemaking cycle in murine sinoatrial node myocytes ]]> https://biorxiv.org/content/10.1101/2021.03.10.434820v1?rss=1 Peters, C. H. Liu, P. Morotti, S. Gantz, S. C. Grandi, E. Bean, B. P. Proenza, C. 2021-03-10 doi:10.1101/2021.03.10.434820 Cold Spring Harbor Laboratory Press 2021-03-10 <![CDATA[ Kidney-Specific WNK1 Amplifies NCC Responsiveness to Potassium Imbalance ]]> https://biorxiv.org/content/10.1101/2021.03.12.435046v1?rss=1 Boyd-Shiwarski, C. R. Beacham, R. T. Griffiths, S. E. Shiwarski, D. J. Knoell, S. A. Nkashama, L. J. Querry, K. E. Marciszyn, A. L. Huang, C.-L. Stocker, S. D. Subramanya, A. R. 2021-03-12 doi:10.1101/2021.03.12.435046 Cold Spring Harbor Laboratory Press 2021-03-12 <![CDATA[ Nicotinamide riboside alleviates Parkinson's disease symptoms but downregulates dopamine metabolism upon lactacystin-induced proteostasis failure ]]> https://biorxiv.org/content/10.1101/2021.03.12.435062v1?rss=1 Turconi, G. Alam, F. SenGupta, T. Pirnes-Karhu, S. Olfat, S. Schmidt, M. S. Mätlik, K. Montano-Rodriguez, A. Heiskanen, V. Piepponen, P. T. Brenner, C. Holmberg, C. I. Nilsen, H. Andressoo, J.-O. Pirinen, E. 2021-03-12 doi:10.1101/2021.03.12.435062 Cold Spring Harbor Laboratory Press 2021-03-12 <![CDATA[ Experience-related remapping of temporal encoding by striatal ensembles. ]]> https://biorxiv.org/content/10.1101/2021.03.12.435177v1?rss=1 Bruce, R. Weber, M. Volkman, R. Oya, M. Emmons, E. Kim, Y. Narayanan, N. 2021-03-12 doi:10.1101/2021.03.12.435177 Cold Spring Harbor Laboratory Press 2021-03-12 <![CDATA[ Structural Covariance Networks in Post-Traumatic Stress Disorder: A Multisite ENIGMA-PGC Study ]]> https://biorxiv.org/content/10.1101/2021.03.13.432212v1?rss=1 Rakesh, G. Sun, D. Logue, M. Clarke-Rubright, E. O Leary, B. M. Haswell, C. Xie, H. Thompson, P. Dennis, E. Jahanshad, N. Koch, S. Frijling, J. Nawijn, L. Olff, M. van Zuiden, M. Rashid, F. Zhu, X. De Bellis, M. Daniels, J. K. Sierk, A. Manthey, A. Stevens, J. S. Jovanovic, T. Stein, M. B. Shenton, M. van der Werff, S. J. A. van der Wee, N. J. A. Vermeiren, R. R. J. M. Schmahl, C. Herzog, J. Kaufman, M. L. O'Connor, L. Lebois, L. A. M. Baker, J. T. Gruber, S. A. Wolff, J. D. Wolf, E. J. Winternitz, S. Gonenc, A. Ressler, K. J. Hofmann, D. Bryant, R. A. 2021-03-16 doi:10.1101/2021.03.13.432212 Cold Spring Harbor Laboratory Press 2021-03-16 <![CDATA[ Topography-dependent gene expression and function of common cell archetypes in large and small porcine airways ]]> https://biorxiv.org/content/10.1101/2021.03.16.435690v1?rss=1 Pezzulo, A. A. Thurman, A. L. Li, X. Villacreses, R. Yu, W. Mather, S. E. Romano-Ibarra, G. S. Meyerholz, D. K. Stoltz, D. A. Welsh, M. J. Thornell, I. M. Zabner, J. 2021-03-17 doi:10.1101/2021.03.16.435690 Cold Spring Harbor Laboratory Press 2021-03-17 <![CDATA[ RABL6A promotes pancreatic neuroendocrine tumor angiogenesis and progression in vivo ]]> https://biorxiv.org/content/10.1101/2021.03.17.435790v1?rss=1 Maharjan, C. K. Kaemmer, C. A. Muniz, V. P. Bauchle, C. Mott, S. L. Zamba, K. D. Breheny, P. Leidinger, M. R. Darbro, B. W. Stephens, S. Meyerholz, D. K. Quelle, D. E. 2021-03-17 doi:10.1101/2021.03.17.435790 Cold Spring Harbor Laboratory Press 2021-03-17 <![CDATA[ The Central Importance of Hub Proteins in a Disease-Gene Network Model: A New Paradigm of Chronic Myeloid Leukemia Disease Study ]]> https://biorxiv.org/content/10.1101/2021.03.21.436331v1?rss=1 Rahman, K. M. T. Islam, M. F. Saha, S. Billah, M. M. 2021-03-22 doi:10.1101/2021.03.21.436331 Cold Spring Harbor Laboratory Press 2021-03-22 <![CDATA[ NeuriteNet: A Convolutional Neural Network for determining morphological differences in neurite growth ]]> https://biorxiv.org/content/10.1101/2021.03.31.437885v1?rss=1 Vecchi, J. T. Mullan, S. Lopez, J. A. Hansen, M. Sonka, M. Lee, A. 2021-03-31 doi:10.1101/2021.03.31.437885 Cold Spring Harbor Laboratory Press 2021-03-31 <![CDATA[ Host Factor Rab11a is Critical for Efficient Assembly of Influenza A Virus Genomic Segments ]]> https://biorxiv.org/content/10.1101/2021.04.06.438577v1?rss=1 Han, J. Ganti, K. Sali, V. K. Twigg, C. Zhang, Y. Manivasagam, S. Liang, C.-Y. Vogel, O. A. Huang, I. Emmanuel, S. N. Plung, J. Radoshevich, L. Perez, J. T. Lowen, A. C. Manicassamy, B. 2021-04-06 doi:10.1101/2021.04.06.438577 Cold Spring Harbor Laboratory Press 2021-04-06 <![CDATA[ Polymersomes decorated with SARS-CoV-2 spike protein receptor binding domain elicit robust humoral and cellular immunity ]]> https://biorxiv.org/content/10.1101/2021.04.08.438884v1?rss=1 Volpatti, L. R. Wallace, R. P. Cao, S. Raczy, M. Wang, R. Gray, L. T. Alpar, A. T. Briquez, P. S. Mitrousis, N. Marchell, T. M. Sasso, M. S. Nguyen, M. Mansurov, A. Budina, E. Solanki, A. Watkins, E. A. Schnorenberg, M. R. Tremain, A. C. Reda, J. W. Nicolaescu, V. Furlong, K. Dvorkin, S. Yu, S. S. Manicassamy, B. LaBelle, J. L. Tirrell, M. V. Randall, G. Kwissa, M. Swartz, M. Hubbell, J. 2021-04-08 doi:10.1101/2021.04.08.438884 Cold Spring Harbor Laboratory Press 2021-04-08 <![CDATA[ Leishmania infantum xenodiagnosis from vertically infected dogs reveals significant skin tropism ]]> https://biorxiv.org/content/10.1101/2021.04.08.438940v1?rss=1 Scorza, B. M. Mahachi, K. G. Cox, A. Toepp, A. J. Leal Lima, A. Kumar Kushwaha, A. Kelly, P. Menenses, C. Wilson, G. Gibson-Corley, K. Bartholomay, L. Kamhawi, S. Petersen, C. A. 2021-04-08 doi:10.1101/2021.04.08.438940 Cold Spring Harbor Laboratory Press 2021-04-08 <![CDATA[ Quantification and image-derived phenotyping of retinal ganglion cell nuclei in the nee mouse model of congenital glaucoma ]]> https://biorxiv.org/content/10.1101/2021.04.13.439698v1?rss=1 van der Heide, C. J. Meyer, K. J. Mercer, H. E. Hedberg-Buenz, A. Anderson, M. G. 2021-04-14 doi:10.1101/2021.04.13.439698 Cold Spring Harbor Laboratory Press 2021-04-14 <![CDATA[ Dendritic GABAergic inhibition controlled by Shh signaling-dependent stellate cell pool is critical for motor learning ]]> https://biorxiv.org/content/10.1101/2021.04.15.439999v1?rss=1 Li, W. Chen, L. Fleming, J. T. Brignola, E. Y. Zavalin, K. Lagrange, A. Rex, T. heiney, S. A. Wojaczynski, G. J. Medina, J. F. Chiang, C. 2021-04-15 doi:10.1101/2021.04.15.439999 Cold Spring Harbor Laboratory Press 2021-04-15 <![CDATA[ Eicosanoid signaling as a therapeutic target in middle-aged mice with severe COVID-19 ]]> https://biorxiv.org/content/10.1101/2021.04.20.440676v1?rss=1 Perlman, S. Wong, L. Y. R. Zheng, J. Wilhelmsen, K. Li, K. Ortiz Bezara, M. E. Schnicker, N. J. Pezzulo, A. A. A. Szachowicz, P. J. Klumpp, K. Aswad, F. Rebo, J. Narumiya, S. Murakami, M. Meyerholz, D. Fortney, K. McCray, P. B. 2021-04-21 doi:10.1101/2021.04.20.440676 Cold Spring Harbor Laboratory Press 2021-04-21 <![CDATA[ Inclusion of environmentally themed search terms improved Elastic Net regression nowcasts of regional Lyme disease rates ]]> https://biorxiv.org/content/10.1101/2021.04.22.440883v1?rss=1 Kontowicz, E. Brown, G. Torner, J. Carrel, M. Baker, K. K. Petersen, C. A. 2021-04-22 doi:10.1101/2021.04.22.440883 Cold Spring Harbor Laboratory Press 2021-04-22 <![CDATA[ Neural correlates of individual differences in speech-in-noise performance in a large cohort of cochlear implant users ]]> https://biorxiv.org/content/10.1101/2021.04.22.440998v1?rss=1 Berger, J. I. Gander, P. E. Kim, S. Schwalje, A. T. Woo, J. Na, Y.-m. Holmes, A. Hong, J. Dunn, C. Hansen, M. Gantz, B. McMurray, B. Griffiths, T. D. Choi, I. 2021-04-22 doi:10.1101/2021.04.22.440998 Cold Spring Harbor Laboratory Press 2021-04-22 <![CDATA[ Fascin limits Myosin activity within Drosophila border cells to control substrate stiffness and promote migration ]]> https://biorxiv.org/content/10.1101/2021.04.27.441651v1?rss=1 Lamb, M. C. Kaluarachchi, C. P. Lansakara, T. I. Lan, Y. Tivanski, A. V. Tootle, T. L. 2021-04-28 doi:10.1101/2021.04.27.441651 Cold Spring Harbor Laboratory Press 2021-04-28 <![CDATA[ Epigenetic Programming during thymic development sets the stage for optimal function in effector T cells via DNA demethylation ]]> https://biorxiv.org/content/10.1101/2021.05.03.442517v1?rss=1 Teghanemt, A. Pulipati, P. Day, K. Yorek, M. S. Yi, R. Misel, K. M. Keen, H. L. Au, C. Maretzky, T. Gurung, P. Littman, D. R. Issuree, P. D. 2021-05-04 doi:10.1101/2021.05.03.442517 Cold Spring Harbor Laboratory Press 2021-05-04 <![CDATA[ TISON: a next-generation multi-scale modeling theatre for in silico systems oncology ]]> https://biorxiv.org/content/10.1101/2021.05.04.442539v1?rss=1 Gondal, M. N. Sultan, M. U. Arif, A. Rehman, A. Awan, H. A. Arshad, Z. Ahmed, W. Chaudhary, M. F. Khan, S. Tanveer, Z. B. Butt, R. N. Hussain, R. Khawar, H. Amina, B. Akbar, R. Abbas, F. Jami, M. N. Nasir, Z. Shah, O. S. Hameed, H. Butt, M. F. Mustafa, G. Ahmad, M. M. Ahmed, S. Qazi, R. Ahmed, F. Ishaq, O. Nabi, S. W. Vanderbauwhede, W. Wajid, B. Shehwana, H. Uddin, E. Safdar, M. Javed, I. Tariq, M. Faisal, A. Chaudhary, S. U. 2021-05-05 doi:10.1101/2021.05.04.442539 Cold Spring Harbor Laboratory Press 2021-05-05 <![CDATA[ Azole resistance is mediated by integration of sterol gene regulation and membrane transporter production by the zinc cluster-containing transcription factor Upc2A in Candida glabrata ]]> https://biorxiv.org/content/10.1101/2021.05.07.443069v1?rss=1 Vu, B. G. Stamnes, M. A. Li, Y. Rogers, P. D. Moye-Rowley, W. S. 2021-05-08 doi:10.1101/2021.05.07.443069 Cold Spring Harbor Laboratory Press 2021-05-08 <![CDATA[ Cell Surface Glycan Engineering Reveals that Matriglycan Alone can Recapitulate Dystroglycan Binding and Function ]]> https://biorxiv.org/content/10.1101/2021.05.10.443358v1?rss=1 Sheikh, M. O. Capicciotti, C. J. Liu, L. Praissman, J. L. Mead, D. G. Brindley, M. A. Willer, T. Campbell, K. P. Moremen, K. W. Wells, L. Boons, G.-J. 2021-05-10 doi:10.1101/2021.05.10.443358 Cold Spring Harbor Laboratory Press 2021-05-10 <![CDATA[ Neuropsychological evidence of multi-domain network hubs in the human thalamus ]]> https://biorxiv.org/content/10.1101/2021.05.10.443403v1?rss=1 Hwang, K. M. Shine, J. Bruss, J. Tranel, D. Boes, A. 2021-05-10 doi:10.1101/2021.05.10.443403 Cold Spring Harbor Laboratory Press 2021-05-10 <![CDATA[ Construction of a 3-color prism-based TIRF microscope to study the interactions and dynamics of macromolecules ]]> https://biorxiv.org/content/10.1101/2021.05.10.443430v1?rss=1 Fairlamb, M. S. Whitaker, A. M. Bain, F. E. Spies, M. Freudenthal, B. D. 2021-05-11 doi:10.1101/2021.05.10.443430 Cold Spring Harbor Laboratory Press 2021-05-11 <![CDATA[ Fly seizure EEG: field potential activity in the Drosophila brain ]]> https://biorxiv.org/content/10.1101/2021.05.10.443444v1?rss=1 Iyengar, A. Wu, C.-F. 2021-05-10 doi:10.1101/2021.05.10.443444 Cold Spring Harbor Laboratory Press 2021-05-10 <![CDATA[ Cortical alpha-synuclein preformed fibrils do not affect interval timing in mice ]]> https://biorxiv.org/content/10.1101/2021.05.10.443485v1?rss=1 Zhang, Q. Abdelmotilib, H. A. Larson, T. Keomanivong, C. Conlon, M. Aldridge, G. Narayanan, N. 2021-05-10 doi:10.1101/2021.05.10.443485 Cold Spring Harbor Laboratory Press 2021-05-10 <![CDATA[ Intravital imaging of Candida albicans identifies differential in vitro and in vivo filamentation phenotypes for transcription factor deletion mutants ]]> https://biorxiv.org/content/10.1101/2021.05.10.443530v1?rss=1 Krysan, D. J. Wakade, R. S. huang, m. Mitchell, A. P. Wellington, M. 2021-05-11 doi:10.1101/2021.05.10.443530 Cold Spring Harbor Laboratory Press 2021-05-11 <![CDATA[ Mice lacking the cAMP effector protein POPDC1 show enhanced hippocampal synaptic plasticity ]]> https://biorxiv.org/content/10.1101/2021.05.12.443909v1?rss=1 Shetty, M. S. Ris, L. Schindler, R. F. R. Mizuno, K. Fedele, L. Giese, K. P. Brand, T. Abel, T. 2021-05-13 doi:10.1101/2021.05.12.443909 Cold Spring Harbor Laboratory Press 2021-05-13 <![CDATA[ Structural and cellular transcriptome foundations of human brain disease ]]> https://biorxiv.org/content/10.1101/2021.05.12.443911v1?rss=1 Zeighami, Y. Bakken, T. E. Nickl-Jockschat, T. Miller, J. A. Evans, A. C. Lein, E. Hawrylycz, M. 2021-05-13 doi:10.1101/2021.05.12.443911 Cold Spring Harbor Laboratory Press 2021-05-13 <![CDATA[ Altered hippocampal transcriptome dynamics following sleep deprivation ]]> https://biorxiv.org/content/10.1101/2021.05.20.445021v1?rss=1 View larger version (27K): org.highwire.dtl.DTLVardef@1e611eborg.highwire.dtl.DTLVardef@1a26aa2org.highwire.dtl.DTLVardef@6e8e2org.highwire.dtl.DTLVardef@1a388f0_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Gaine, M. E. Bahl, E. Chatterjee, S. Michaelson, J. J. Abel, T. Lyons, L. C. 2021-05-21 doi:10.1101/2021.05.20.445021 Cold Spring Harbor Laboratory Press 2021-05-21 <![CDATA[ Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant ]]> https://biorxiv.org/content/10.1101/2021.05.20.445060v1?rss=1 Gray, L. T. Raczy, M. M. Briquez, P. S. Marchell, T. M. Alpar, A. T. Wallace, R. P. Volpatti, L. R. Sasso, M. S. Cao, S. Nguyen, M. Mansurov, A. Budina, E. Watkins, E. A. Solanki, A. Mitrousis, N. Reda, J. W. Yu, S. S. Tremain, A. C. Wang, R. Nicolaescu, V. Furlong, K. Dvorkin, S. Manicassamy, B. Randall, G. Wilson, D. S. Kwissa, M. Swartz, M. A. Hubbell, J. A. 2021-05-21 doi:10.1101/2021.05.20.445060 Cold Spring Harbor Laboratory Press 2021-05-21 <![CDATA[ AxonDeep: Automated Optic Nerve Axon Segmentation in Mice with Deep Learning. ]]> https://biorxiv.org/content/10.1101/2021.05.21.445196v1?rss=1 Deng, W. Hedberg-Buenz, A. Soukup, D. A. Taghizadeh, S. Anderson, M. G. Garvin, M. K. 2021-05-23 doi:10.1101/2021.05.21.445196 Cold Spring Harbor Laboratory Press 2021-05-23 <![CDATA[ In vivo complex haploinsufficiency-based genetic analysis identifies a transcription factor circuit regulating Candida albicans oropharyngeal infection and epithelial cell endocytosis ]]> https://biorxiv.org/content/10.1101/2021.05.24.445409v1?rss=1 Solis, N. V. Wakade, R. S. Ollinger, T. L. Wellington, M. Mitchell, A. P. Filler, S. G. Krysan, D. J. 2021-05-24 doi:10.1101/2021.05.24.445409 Cold Spring Harbor Laboratory Press 2021-05-24 <![CDATA[ Effective interferon (IFN)-lambda treatment regimen to control lethal MERS-CoV infection in mice ]]> https://biorxiv.org/content/10.1101/2021.05.26.445685v1?rss=1 Dijkman, R. Selvaraj, M. Gad, H. H. More, S. Hartmann, R. Perlman, S. Thiel, V. Channappanavar, R. 2021-05-27 doi:10.1101/2021.05.26.445685 Cold Spring Harbor Laboratory Press 2021-05-27 <![CDATA[ MK2a inhibitor CMPD1 abrogates chikungunya virus infection by modulating actin remodeling pathway ]]> https://biorxiv.org/content/10.1101/2021.05.26.445768v1?rss=1 Chattopadhyay, S. Mamidi, P. Nayak, T. K. Kumar, A. Kumar, S. Chatterjee, S. De, S. Datey, A. Laha, E. Ray, A. Chattopadhyay, S. 2021-05-26 doi:10.1101/2021.05.26.445768 Cold Spring Harbor Laboratory Press 2021-05-26 <![CDATA[ Female mice exhibit a more sensitive automated squint response to pain induced by CGRP and amylin ]]> https://biorxiv.org/content/10.1101/2021.05.26.445893v1?rss=1 Rea, B. J. Sowers, L. P. Davison, A. L. Fairbanks, A. M. Wattiez, A.-S. Poolman, P. Kardon, R. H. Russo, A. F. 2021-05-27 doi:10.1101/2021.05.26.445893 Cold Spring Harbor Laboratory Press 2021-05-27 <![CDATA[ Functional connectome reorganization relates to post-stroke motor recovery and structural disconnection ]]> https://biorxiv.org/content/10.1101/2021.05.27.445834v1?rss=1 Olafson, E. Jamison, K. Sweeney, E. Liu, H. Wang, D. Bruss, J. Boes, A. Kuceyeski, A. 2021-05-28 doi:10.1101/2021.05.27.445834 Cold Spring Harbor Laboratory Press 2021-05-28 <![CDATA[ A Universal Approach to Analyzing Transmission Electron Microscopy with ImageJ ]]> https://biorxiv.org/content/10.1101/2021.05.27.446036v1?rss=1 Lam, J. Biete, M. Mungai, M. AshShareef, S. Neikirk, K. Garza Lopez, E. Christensen, T. A. Salisbury, J. L. Katti, P. Glancy, B. Pereira, R. O. Abel, E. D. Hinton, A. 2021-05-29 doi:10.1101/2021.05.27.446036 Cold Spring Harbor Laboratory Press 2021-05-29 <![CDATA[ Ring Finger Protein 213 Assembles into a Sensor for ISGylated Proteins with Antimicrobial Activity ]]> https://biorxiv.org/content/10.1101/2021.06.03.446796v1?rss=1 Thery, F. Martina, L. Asselman, C. Repo, H. Zhang, Y. Sedeyn, K. Moschonas, G. D. Bredow, C. Teo, Q. W. Zhang, J. Vessely, M. Leandro, K. Eggermont, D. De Sutter, D. Boucher, K. Hochepied, T. Festjens, N. Callewaert, N. Saelens, X. Dermaut, B. Knobeloch, K.-P. Beling, A. Sanyal, S. Radoshevich, L. Eyckerman, S. Impens, F. 2021-06-03 doi:10.1101/2021.06.03.446796 Cold Spring Harbor Laboratory Press 2021-06-03 <![CDATA[ An Alanine Aminotransferase is Required for Polysaccharide Regulation and Resistance of Aspergillus fumigatus Biofilms to Echinocandin Treatment ]]> https://biorxiv.org/content/10.1101/2021.06.03.446912v1?rss=1 Kerkaert, J. D. Le Mauff, F. Wucher, B. R. Beattie, S. R. Vesely, E. M. Sheppard, D. Nadell, C. D. A. Cramer, R. 2021-06-05 doi:10.1101/2021.06.03.446912 Cold Spring Harbor Laboratory Press 2021-06-05 <![CDATA[ Asexual freshwater snails make poor mate choice decisions ]]> https://biorxiv.org/content/10.1101/2021.06.08.447504v1?rss=1 Stork, S. Jalinsky, J. Neiman, M. 2021-06-09 doi:10.1101/2021.06.08.447504 Cold Spring Harbor Laboratory Press 2021-06-09 <![CDATA[ AP-2α and AP-2β cooperatively function in the craniofacial surface ectoderm to regulate chromatin and gene expression dynamics during facial development. ]]> https://biorxiv.org/content/10.1101/2021.06.10.447717v1?rss=1 Van Otterloo, E. Jones, K. Pike, H. Li, H. Milanda, I. Williams, T. 2021-06-10 doi:10.1101/2021.06.10.447717 Cold Spring Harbor Laboratory Press 2021-06-10 <![CDATA[ Phosphatidylserine Receptors Enhance SARS-CoV-2 Infection: AXL as a Therapeutic Target for COVID-19 ]]> https://biorxiv.org/content/10.1101/2021.06.15.448419v1?rss=1 Bohan, D. Van Ert, H. Ruggio, N. Rogers, K. J. Baddredine, M. Briseno, J. A. A. Rojas Chavez, R. A. Gao, B. Stokowy, T. Christakou, E. Micklem, D. Gausdal, G. Haim, H. Minna, J. Lorens, J. B. Maury, W. 2021-06-15 doi:10.1101/2021.06.15.448419 Cold Spring Harbor Laboratory Press 2021-06-15 <![CDATA[ Targeting Gi/o protein-coupled receptor signaling blocks HER2-induced breast cancer development and enhances HER2-targeted therapy ]]> https://biorxiv.org/content/10.1101/2021.06.15.448534v1?rss=1 Lyu, C. Ye, Y. Lensing, M. Wagner, K.-U. Weigel, R. Chen, S. 2021-06-15 doi:10.1101/2021.06.15.448534 Cold Spring Harbor Laboratory Press 2021-06-15 <![CDATA[ Communication between the mediodorsal thalamus and prelimbic cortex regulates timing performance in rats ]]> https://biorxiv.org/content/10.1101/2021.06.18.449036v1?rss=1 De Corte, B. J. Heslin, K. A. Cremers, N. Freeman, J. H. Parker, K. L. 2021-06-19 doi:10.1101/2021.06.18.449036 Cold Spring Harbor Laboratory Press 2021-06-19 <![CDATA[ Cell culture evolution of a HSV-1/VZV UL34/ORF24 chimeric virus reveals novel functions for HSV genes in capsid nuclear egress ]]> https://biorxiv.org/content/10.1101/2021.06.18.449081v1?rss=1 Roller, R. J. Hassman, T. Haugo-Crooks, A. 2021-06-19 doi:10.1101/2021.06.18.449081 Cold Spring Harbor Laboratory Press 2021-06-19 <![CDATA[ Multiple mechanisms impact fluconazole resistance of mutant Erg11 proteins in Candida glabrata ]]> https://biorxiv.org/content/10.1101/2021.06.23.449691v1?rss=1 Vu, B. Moye-Rowley, W. S. 2021-06-24 doi:10.1101/2021.06.23.449691 Cold Spring Harbor Laboratory Press 2021-06-24 <![CDATA[ Sex Differences in Cerebral Edema after Experimental Traumatic Brain Injury ]]> https://biorxiv.org/content/10.1101/2021.06.25.449932v1?rss=1 Minchew, H. M. Christian, S. K. Keselman, P. Hu, J. Andrews, B. T. Harris, J. L. 2021-06-25 doi:10.1101/2021.06.25.449932 Cold Spring Harbor Laboratory Press 2021-06-25 <![CDATA[ Developmental onset of a cerebellar-dependent forward model of movement in motor thalamus ]]> https://biorxiv.org/content/10.1101/2021.06.25.449956v1?rss=1 Dooley, J. C. Sokoloff, G. Blumberg, M. S. 2021-06-25 doi:10.1101/2021.06.25.449956 Cold Spring Harbor Laboratory Press 2021-06-25 <![CDATA[ A comprehensive approach for artifact-free sample preparation and assessment of mitochondrial morphology in tissue and cultured cells ]]> https://biorxiv.org/content/10.1101/2021.06.27.450055v1?rss=1 Hinton, A. Katti, P. Christensen, T. A. Mungai, M. Shao, J. Zhang, L. Trushin, S. Alghanem, A. Jaspersen, A. Geroux, R. E. Neikirk, K. Biete, M. Garza Lopez, E. Vue, Z. Beasley, H. Marshall, A. Hicsasmaz, I. Edmonds, R. A. C. Dajles, A. Koo, Y. D. Bacevac, S. Salisbury, J. L. Pereira, R. O. Glancy, B. Trushina, E. Abel, E. D. 2021-06-29 doi:10.1101/2021.06.27.450055 Cold Spring Harbor Laboratory Press 2021-06-29 <![CDATA[ Sleep deprivation reduces the density of individual spine subtypes in a branch-specific fashion in CA1 neurons ]]> https://biorxiv.org/content/10.1101/2021.06.30.450529v1?rss=1 Bolsius, Y. G. Meerlo, P. Kas, M. J. Abel, T. Havekes, R. 2021-07-01 doi:10.1101/2021.06.30.450529 Cold Spring Harbor Laboratory Press 2021-07-01 <![CDATA[ Genome-wide association study and functional validation implicates JADE1 in tauopathy ]]> https://biorxiv.org/content/10.1101/2021.06.30.450599v1?rss=1 Farrell, K. Kim, S. Han, N. Iida, M. A. Gonzalez, E. Otero-Garcia, M. Walker, J. Richardson, T. Renton, A. E. Andrews, S. J. Fulton-Howard, B. Humphrey, J. Vialle, R. A. Bowles, K. R. Whitney, K. Dangoor, D. K. Marcora, E. Hefti, M. M. Casella, A. Bhangale, T. Hunkapiller, J. Ayalon, G. Graham, R. Cherry, J. D. Cortes, E. Borukov, V. McKee, A. C. Stein, T. D. Vonsattel, J. P. Teich, A. F. Gearing, M. Glass, J. Troncoso, J. C. Frosch, M. P. Hyman, B. T. Dickson, D. W. Murray, M. E. Attems, J. Flanagan, M. E. Mao, Q. Mesulam, M. M. Weintraub, S. Woltjer, 2021-07-01 doi:10.1101/2021.06.30.450599 Cold Spring Harbor Laboratory Press 2021-07-01 <![CDATA[ Atypical gaze patterns in autism are heterogeneous across subjects but reliable within individuals ]]> https://biorxiv.org/content/10.1101/2021.07.01.450793v1?rss=1 Keles, U. Kliemann, D. Byrge, L. Saarimaki, H. Paul, L. K. Kennedy, D. P. Adolphs, R. 2021-07-02 doi:10.1101/2021.07.01.450793 Cold Spring Harbor Laboratory Press 2021-07-02 <![CDATA[ p53-mediated neurodegeneration in the absence of the nuclear protein Akirin2 ]]> https://biorxiv.org/content/10.1101/2021.07.05.451155v1?rss=1 Peek, S. L. Bosch, P. J. Bahl, E. Iverson, B. J. Parida, M. Bais, P. Manak, J. R. Michaelson, J. Burgess, R. W. Weiner, J. A. 2021-07-06 doi:10.1101/2021.07.05.451155 Cold Spring Harbor Laboratory Press 2021-07-06 <![CDATA[ Differential impact of Kv8.2 loss on rod and cone signaling and degeneration. ]]> https://biorxiv.org/content/10.1101/2021.07.05.451197v1?rss=1 Inamdar, S. M. Lankford, C. K. Poria, D. Laird, J. G. Solessio, E. Kefalov, V. J. Baker, S. A. 2021-07-06 doi:10.1101/2021.07.05.451197 Cold Spring Harbor Laboratory Press 2021-07-06 <![CDATA[ Autoimmunity increases susceptibility to and mortality from sepsis ]]> https://biorxiv.org/content/10.1101/2021.07.06.451335v1?rss=1 Jensen, I. J. Jensen, S. N. McGonagill, P. W. Griffith, T. S. Mangalam, A. K. Badovinac, V. P. 2021-07-08 doi:10.1101/2021.07.06.451335 Cold Spring Harbor Laboratory Press 2021-07-08 <![CDATA[ Oncogenic RABL6A promotes NF1-associated MPNST progression in vivo ]]> https://biorxiv.org/content/10.1101/2021.07.07.451475v1?rss=1 Kohlmeyer, J. L. Kaemmer, C. A. Lingo, J. J. Leidinger, M. R. Meyerholz, D. K. Tanas, M. R. Dodd, R. D. Quelle, D. E. 2021-07-07 doi:10.1101/2021.07.07.451475 Cold Spring Harbor Laboratory Press 2021-07-07 <![CDATA[ A specific relationship between musical sophistication and auditory working memory ]]> https://biorxiv.org/content/10.1101/2021.07.08.451659v1?rss=1 Lad, M. Billig, A. J. Kumar, S. Griffiths, T. 2021-07-09 doi:10.1101/2021.07.08.451659 Cold Spring Harbor Laboratory Press 2021-07-09 <![CDATA[ Phenotypic and genomic diversification in complex carbohydrate degrading human gut bacteria ]]> https://biorxiv.org/content/10.1101/2021.07.15.452266v1?rss=1 Pudlo, N. A. Urs, K. Crawford, R. Pirani, A. Atherly, T. Jimenez, R. Terrapon, N. Henrissat, B. Peterson, D. A. Ziemer, C. Snitkin, E. S. Martens, E. 2021-07-15 doi:10.1101/2021.07.15.452266 Cold Spring Harbor Laboratory Press 2021-07-15 <![CDATA[ Huntington's disease age at motor onset is modified by the tandem hexamer repeat in TCERG1 ]]> https://biorxiv.org/content/10.1101/2021.07.16.452643v1?rss=1 Lobanov, S. V. McAllister, B. McDade-Kumar, M. Landwehrmeyer, G. B. Rosser, A. E. REGISTRY Investigators of the European Huntington's disease network, Paulsen, J. S. PREDICT-HD Investigators of the Huntington Study Group, Lee, J.-M. MacDonald, M. E. Gusella, J. Ryten, M. Williams, N. Holmans, P. Massey, T. H. Jones, L. 2021-07-19 doi:10.1101/2021.07.16.452643 Cold Spring Harbor Laboratory Press 2021-07-19 <![CDATA[ Chloride oscillation in pacemaker neurons regulates circadian rhythms through a chloride-sensing WNK kinase signaling cascade ]]> https://biorxiv.org/content/10.1101/2021.07.16.452737v1?rss=1 Schellinger, J. N. Sun, Q. Pleinis, J. M. An, S.-W. Hu, J. Mercenne, G. Titos, I. Huang, C.-L. Rothenfluh, A. Rodan, A. R. 2021-07-18 doi:10.1101/2021.07.16.452737 Cold Spring Harbor Laboratory Press 2021-07-18 <![CDATA[ Diet modifies allele-specific phenotypes in Drosophila carrying epilepsy-associated PNPO variants ]]> https://biorxiv.org/content/10.1101/2021.07.19.452889v1?rss=1 Chi, W. Iyengar, A. Fu, W. Liu, W. Berg, A. E. Wu, C.-F. Zhuang, X. 2021-07-20 doi:10.1101/2021.07.19.452889 Cold Spring Harbor Laboratory Press 2021-07-20 <![CDATA[ Nonlinear Functional Network Connectivity In Resting fMRI Data ]]> https://biorxiv.org/content/10.1101/2021.07.20.452982v1?rss=1 Motlaghian, S. Belger, A. Bustillo, J. Ford, J. Lim, K. Mathalon, D. Mueller, B. Oleary, D. Pearlson, G. Potkin, S. Preda, A. Van Erp, T. Calhoun, V. 2021-07-21 doi:10.1101/2021.07.20.452982 Cold Spring Harbor Laboratory Press 2021-07-21 <![CDATA[ Caldendrin represses neurite regeneration via a sex-dependent mechanism in sensory neurons ]]> https://biorxiv.org/content/10.1101/2021.07.26.453831v1?rss=1 Lopez, J. A. Yamamoto, A. Vecchi, J. T. Hagen, J. Lee, A. 2021-07-26 doi:10.1101/2021.07.26.453831 Cold Spring Harbor Laboratory Press 2021-07-26 <![CDATA[ ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals. ]]> https://biorxiv.org/content/10.1101/2021.07.27.454047v1?rss=1 Pashkova, N. Gakhar, L. Winistorfer, S. Minard, A. Y. Schnicker, N. J. Yu, L. Johnson, I. E. Piper, R. C. 2021-07-27 doi:10.1101/2021.07.27.454047 Cold Spring Harbor Laboratory Press 2021-07-27 <![CDATA[ Brain structure and function predict adherence to an exercise intervention in older adults ]]> https://biorxiv.org/content/10.1101/2021.07.30.454451v1?rss=1 Morris, T. P. Burzynska, A. Voss, M. Fanning, J. Salerno, E. A. Prakash, R. Gothe, N. P. Whitfield-Gabrieli, S. Hillman, C. H. McAuley, E. Kramer, A. F. 2021-08-01 doi:10.1101/2021.07.30.454451 Cold Spring Harbor Laboratory Press 2021-08-01 <![CDATA[ Lipid droplets regulate actin remodeling via prostaglandin signaling during Drosophila oogenesis ]]> https://biorxiv.org/content/10.1101/2021.08.02.454724v1?rss=1 Giedt, M. S. Thomalla, J. M. Johnson, M. R. Lai, Z. W. Tootle, T. L. Welte, M. A. 2021-08-02 doi:10.1101/2021.08.02.454724 Cold Spring Harbor Laboratory Press 2021-08-02 <![CDATA[ Limited variation between SARS-CoV-2-infected individuals in domain specificity and relative potency of the antibody response against the spike glycoprotein ]]> https://biorxiv.org/content/10.1101/2021.08.04.455181v1?rss=1 Van Ert, H. A. Bohan, D. W. Rogers, K. J. Fili, M. Rojas Chavez, A. R. Qing, E. Han, C. Dempewolf, S. M. Hu, G. Schwery, N. Sevcik, K. M. Ruggio, N. Boyt, D. Pentella, M. Gallagher, T. Jackson, J. B. Merrill, A. E. Knudson, C. M. Brown, G. Maury, W. Haim, H. 2021-08-05 doi:10.1101/2021.08.04.455181 Cold Spring Harbor Laboratory Press 2021-08-05 <![CDATA[ Identification of HCN1 as a 14-3-3 client ]]> https://biorxiv.org/content/10.1101/2021.08.19.457009v1?rss=1 Lankford, C. K. Houtman, J. C. Baker, S. A. 2021-08-19 doi:10.1101/2021.08.19.457009 Cold Spring Harbor Laboratory Press 2021-08-19 <![CDATA[ FtsN activates septal cell wall synthesis by forming a processive complex with the septum-specific peptidoglycan synthase in E. coli ]]> https://biorxiv.org/content/10.1101/2021.08.23.457437v1?rss=1 Lyu, Z. Yahashiri, A. Yang, X. McCausland, J. W. Kaus, G. M. McQuillen, R. Weiss, D. S. Xiao, J. 2021-08-24 doi:10.1101/2021.08.23.457437 Cold Spring Harbor Laboratory Press 2021-08-24 <![CDATA[ Multiple Sclerosis Patients have an Altered Gut Mycobiome and Increased Fungal to Bacterial Richness Running Title: RRMS Patients have Gut Fungal Dysbiosis ]]> https://biorxiv.org/content/10.1101/2021.08.30.458212v1?rss=1 Yadav, M. Ali, S. Shrode, R. L. Shahi, S. K. Jensen, S. N. Hoang, J. Cassidy, S. Olalde, H. Guseva, N. Paullus, M. Cherwin, C. Wang, K. Cho, T. Kamholz, J. Mangalam, A. K. 2021-09-01 doi:10.1101/2021.08.30.458212 Cold Spring Harbor Laboratory Press 2021-09-01 <![CDATA[ ISL1 is an essential determinant of structural and functional tonotopic representation of sound ]]> https://biorxiv.org/content/10.1101/2021.09.03.458707v1?rss=1 Filova, I. Pysanenko, K. Tavakoli, M. Vochyanova, S. Dvorakova, M. Bohuslavova, R. Smolik, O. Benesova, S. Valihrach, L. Yamoah, E. N. Syka, J. Fritzsch, B. Pavlinkova, G. 2021-09-05 doi:10.1101/2021.09.03.458707 Cold Spring Harbor Laboratory Press 2021-09-05 <![CDATA[ Protein Structure Prediction Using a Maximum Likelihood Formulation of a Recurrent Geometric Network ]]> https://biorxiv.org/content/10.1101/2021.09.03.458873v1?rss=1 Qi, G. Tollefson, M. R. Gogal, R. A. Smith, R. J. H. AlQuraishi, M. Schnieders, M. J. 2021-09-04 doi:10.1101/2021.09.03.458873 Cold Spring Harbor Laboratory Press 2021-09-04 <![CDATA[ An Extended Coatomer Binding Motif in the SARS-CoV-2 Spike Protein ]]> https://biorxiv.org/content/10.1101/2021.09.03.458953v1?rss=1 Dey, D. Singh, S. Khan, S. Martin, M. Schnicker, N. Gakhar, L. Pierce, B. Hasan, S. S. 2021-09-04 doi:10.1101/2021.09.03.458953 Cold Spring Harbor Laboratory Press 2021-09-04 <![CDATA[ Angiotensin II Inhibits the A-type K+ Current of Hypothalamic Paraventricular Nucleus Neurons in Rats with Heart Failure: Role of MAPK-ERK1/2 Signaling ]]> https://biorxiv.org/content/10.1101/2021.09.12.459939v1?rss=1 View larger version (18K): org.highwire.dtl.DTLVardef@1e4ec4org.highwire.dtl.DTLVardef@1c54be0org.highwire.dtl.DTLVardef@1f86529org.highwire.dtl.DTLVardef@b98aa2_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Roy, R. K. Ferreira-Neto, H. C. Felder, R. B. Stern, J. E. 2021-09-15 doi:10.1101/2021.09.12.459939 Cold Spring Harbor Laboratory Press 2021-09-15 <![CDATA[ Blood-based untargeted metabolomics in Relapsing-Remitting Multiple Sclerosis revealed the testable therapeutic target ]]> https://biorxiv.org/content/10.1101/2021.09.13.460085v1?rss=1 Zahoor, I. Suhail, H. Dutta, I. Ahmed, M. E. Poisson, L. Waters, J. Bin, R. Singh, J. Cerghet, M. Kumar, A. Hoda, N. Rattan, R. Mangalam, A. K. Giri, s. 2021-09-15 doi:10.1101/2021.09.13.460085 Cold Spring Harbor Laboratory Press 2021-09-15 <![CDATA[ Metabolic Derangement in Polycystic Kidney Disease Mouse Models Is Ameliorated by Mitochondrial-Targeted Antioxidants ]]> https://biorxiv.org/content/10.1101/2021.09.15.460510v1?rss=1 Daneshgar, N. Baguley, A. W. Liang, P.-I. Wu, F. Chu, Y. Kinter, M. T. Benavides, G. A. Johnson, M. S. Darley-Usmar, V. Zhang, J. Chan, K.-S. Dai, D.-F. 2021-09-17 doi:10.1101/2021.09.15.460510 Cold Spring Harbor Laboratory Press 2021-09-17 <![CDATA[ Single shot detector application for image disease localization ]]> https://biorxiv.org/content/10.1101/2021.09.21.461307v1?rss=1 pawar, s. Stanam, A. Chopade, R. 2021-09-24 doi:10.1101/2021.09.21.461307 Cold Spring Harbor Laboratory Press 2021-09-24 <![CDATA[ A Comparison of Methods to Harmonize Cortical Thickness Measurements Across Scanners and Sites ]]> https://biorxiv.org/content/10.1101/2021.09.22.461242v1?rss=1 Sun, D. Rakesh, G. Clarke-Rubright, E. K. Haswell, C. C. Logue, M. O'Leary, B. M. Cotton, A. S. Xie, H. Dennis, E. L. Jahanshad, N. Salminen, L. E. Thomopolous, S. I. Rashid, F. Ching, C. R. K. Koch, S. B. J. Frijling, J. L. Nawijn, L. van Zuiden, M. Zhu, X. Suarez-Jimenez, B. Sierk, A. Walter, H. Manthey, A. Stevens, J. S. Fani, N. van Rooij, S. J. H. Stein, M. Bomyea, J. Koerte, I. K. Choi, K. van der Werff, S. J. A. Vermeiren, R. R. J. M. Herzog, J. Lebois, L. A. M. Baker, J. T. Ressler, K. J. Olson, E. A. Straube, T. Korgaonkar, M. S. Andrew, E. Zhu, 2021-09-24 doi:10.1101/2021.09.22.461242 Cold Spring Harbor Laboratory Press 2021-09-24 <![CDATA[ Tyr is Responsible for the Cctq1a QTL and Links Developmental Environment to Central Corneal Thickness Determination ]]> https://biorxiv.org/content/10.1101/2021.09.22.461410v1?rss=1 Meyer, K. J. Larson, D. R. Whitmore, S. S. van der Heide, C. J. Hedberg-Buenz, A. Dutca, L. M. Koli, S. Pomernackas, N. Mercer, H. E. Mansaray, M. N. Paradee, W. J. Wang, K. Nair, K. S. Scheetz, T. E. Anderson, M. G. 2021-09-24 doi:10.1101/2021.09.22.461410 Cold Spring Harbor Laboratory Press 2021-09-24 <![CDATA[ Hyperglycemia-induced alteration of ER redox homeostasis delays ER export of proinsulin ]]> https://biorxiv.org/content/10.1101/2021.09.22.461417v1?rss=1 Rohli, K. E. Boyer, C. K. Bearrows, S. C. Moyer, M. R. Elison, W. S. Bauchle, C. J. Blom, S. E. Yu, C.-L. Pope, M. R. Zhang, J. Wang, Y. Stephens, S. B. 2021-09-23 doi:10.1101/2021.09.22.461417 Cold Spring Harbor Laboratory Press 2021-09-23 <![CDATA[ Mammals adjust diel activity across gradients of urbanization ]]> https://biorxiv.org/content/10.1101/2021.09.24.461702v1?rss=1 Gallo, T. Fidino, M. Gerber, B. Ahlers, A. A. Angstmann, J. L. Amaya, M. Concilio, A. L. Drake, D. Gay, D. Lehrer, E. W. Murray, M. H. Ryan, T. J. St. Clair, C. C. Salsbury, C. M. Sander, H. A. Stankowich, T. Williamson, J. Belaire, J. A. Simon, K. Magle, S. 2021-09-24 doi:10.1101/2021.09.24.461702 Cold Spring Harbor Laboratory Press 2021-09-24 <![CDATA[ Practices for Measuring 3D Organelle Morphology and Generating Surfaces with Amira ]]> https://biorxiv.org/content/10.1101/2021.09.25.461807v1?rss=1 View larger version (43K): org.highwire.dtl.DTLVardef@1c40041org.highwire.dtl.DTLVardef@ecde92org.highwire.dtl.DTLVardef@10870daorg.highwire.dtl.DTLVardef@1290c3b_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Garza Lopez, E. Vue, Z. Katti, P. Neikirk, K. Biete, M. Lam, J. Beasley, H. Marshall, A. Rodman, T. Christensen, T. A. Salisbury, J. L. Vang, L. Mungai, M. AshShareef, S. Murray, S. Shao, J. Streeter, J. Glancy, B. Pereira, R. O. Abel, E. D. Hinton, A. 2021-09-28 doi:10.1101/2021.09.25.461807 Cold Spring Harbor Laboratory Press 2021-09-28 <![CDATA[ Systematic Transmission Electron Microscopy-Based Identification of Cellular Degradation Machinery ]]> https://biorxiv.org/content/10.1101/2021.09.26.461841v1?rss=1 Neikirk, K. Vue, Z. Katti, P. Shao, J. Christensen, T. A. Garza Lopez, E. Marshall, A. Palavicino-Maggio, C. Ponce, J. Alghanem, A. Vang, L. Beasley, H. Rodman, T. Mungai, M. Correia, M. Exil, V. Murray, S. Salisbury, J. L. Glancy, B. Pereira, R. O. Abel, E. D. Hinton, A. 2021-09-27 doi:10.1101/2021.09.26.461841 Cold Spring Harbor Laboratory Press 2021-09-27 <![CDATA[ Sex Differences in Brain Tumor Glutamine Metabolism Reveal Sex-Specific Vulnerabilities to Treatment ]]> https://biorxiv.org/content/10.1101/2021.09.29.461531v1?rss=1 Sponagel, J. Jones, J. K. Frankfater, C. Zhang, S. Tung, O. Cho, K. Tinkum, K. L. Gass, H. Nunez, E. Spitz, D. R. Chinnaiyan, P. Schaefer, J. Patti, G. J. Graham, M. S. Mauguen, A. Grkovski, M. Dunphy, M. P. Krebs, S. Luo, J. Rubin, J. B. Ippolito, J. E. 2021-10-01 doi:10.1101/2021.09.29.461531 Cold Spring Harbor Laboratory Press 2021-10-01 <![CDATA[ Severe distortion in the representation of foveal visual image locations in short term memory ]]> https://biorxiv.org/content/10.1101/2021.10.03.462912v1?rss=1 Willeke, K. Cardenas, A. R. Bellet, J. Hafed, Z. M. 2021-10-04 doi:10.1101/2021.10.03.462912 Cold Spring Harbor Laboratory Press 2021-10-04 <![CDATA[ Video-evoked fMRI BOLD responses are highly consistent across different data acquisition sites ]]> https://biorxiv.org/content/10.1101/2021.10.04.463088v1?rss=1 Byrge, L. Kliemann, D. He, Y. Cheng, H. Tyszka, J. M. Adolphs, R. Kennedy, D. P. 2021-10-05 doi:10.1101/2021.10.04.463088 Cold Spring Harbor Laboratory Press 2021-10-05 <![CDATA[ Disruption of nucleoid expanded conformation by toxic aberrant proteins synthesized in Escherichia coli ]]> https://biorxiv.org/content/10.1101/2021.10.06.463398v1?rss=1 Tawde, M. Bior, A. Feiss, M. Freimuth, P. 2021-10-06 doi:10.1101/2021.10.06.463398 Cold Spring Harbor Laboratory Press 2021-10-06 <![CDATA[ A sensitive and specific genetically encodable biosensor for potassium ions ]]> https://biorxiv.org/content/10.1101/2021.10.07.463410v1?rss=1 Wu, S.-Y. Wen, Y. Serre, N. B. C. Laursen, C. C. H. Dietz, A. G. Taylor, B. R. Aggarwal, A. Rancic, V. Becker, M. Ballanyi, K. Podgorski, K. Hirase, H. Nedergaard, M. Fendrych, M. Lemieux, M. J. Eberl, D. F. Kay, A. R. Campbell, R. E. Shen, Y. 2021-10-09 doi:10.1101/2021.10.07.463410 Cold Spring Harbor Laboratory Press 2021-10-09 <![CDATA[ Loss-of-function ROX1 mutations suppress the fluconazole susceptibility of upc2AΔ mutation in Candida glabrata, implicating additional positive regulators of ergosterol biosynthesis ]]> https://biorxiv.org/content/10.1101/2021.10.07.463606v1?rss=1 Ollinger, T. L. Vu, B. Murante, D. Parker, J. Simonicova, L. Doorley, L. A. Stamnes, M. A. Kelly, S. L. Rogers, P. D. Moye-Rowley, W. S. Krysan, D. J. 2021-10-10 doi:10.1101/2021.10.07.463606 Cold Spring Harbor Laboratory Press 2021-10-10 <![CDATA[ Whole genome sequence analysis of blood lipid levels in >66,000 individuals ]]> https://biorxiv.org/content/10.1101/2021.10.11.463514v1?rss=1 Selvaraj, M. S. Li, X. Li, Z. Pampana, A. Zhang, D. Y. Park, J. Aslibekyan, S. Bis, J. C. Brody, J. A. Cade, B. E. Chuang, L.-M. Chung, R.-H. Curran, J. E. de las Fuentes, L. de Vries, P. S. Duggirala, R. Freedman, B. I. Graff, M. Guo, X. Heard-Costa, N. Hidalgo, B. Hwu, C.-M. Irvin, M. R. Kelly, T. N. Kral, B. G. Lange, L. Li, X. Lisa, M. Lubitz, S. A. Manichaikul, A. W. Michael, P. Montasser, M. E. Morrison, A. C. Naseri, T. O'Connell, J. R. Palmer, N. D. Peyser, P. A. Reupena, M. S. Smith, J. A. Sun, X. Taylor, K. D. Tracy, R. P. Tsai, M. Y. Wang, 2021-10-12 doi:10.1101/2021.10.11.463514 66,000 individuals]]> Cold Spring Harbor Laboratory Press 2021-10-12 <![CDATA[ The power of peer networking for improving STEM faculty job applications: a successful pilot program ]]> https://biorxiv.org/content/10.1101/2021.10.16.464662v1?rss=1 Guardia, C. M. Kane, E. Tebo, A. G. Sanders, A. A. W. M. Kaya, D. Grogan, K. E. 2021-10-18 doi:10.1101/2021.10.16.464662 Cold Spring Harbor Laboratory Press 2021-10-18 <![CDATA[ Treatment with IFB-088 improves neuropathy in CMT1A and CMT1B mice ]]> https://biorxiv.org/content/10.1101/2021.10.18.464779v1?rss=1 Bai, Y. Treins, C. Volpi, V. G. scapin, c. Ferri, C. Mastrangelo, R. Touvier, T. Florio, F. Bianchi, F. Del Carro, U. Baas, F. F. Wang, D. Miniou, P. Guedat, P. Shy, M. E. D'Antonio, M. 2021-10-18 doi:10.1101/2021.10.18.464779 Cold Spring Harbor Laboratory Press 2021-10-18 <![CDATA[ Endoplasmic Reticulum Chaperone Genes Encode Effectors of Long-Term Memory ]]> https://biorxiv.org/content/10.1101/2021.10.20.465191v1?rss=1 Chatterjee, S. Bahl, E. Mukherjee, U. Walsh, E. N. Shetty, M. S. Yan, A. L. Vanrobaeys, Y. Lederman, J. D. Giese, K. P. Michaelson, J. Abel, T. 2021-10-21 doi:10.1101/2021.10.20.465191 Cold Spring Harbor Laboratory Press 2021-10-21 <![CDATA[ Distribution of multi-unit pitch responses recorded intracranially from human auditory cortex ]]> https://biorxiv.org/content/10.1101/2021.10.22.465330v1?rss=1 Berger, J. I. Gander, P. E. Kikuchi, Y. Kumar, S. Kovach, C. K. Oya, H. Kawasaki, H. Howard, M. A. Griffiths, T. D. 2021-10-24 doi:10.1101/2021.10.22.465330 Cold Spring Harbor Laboratory Press 2021-10-24 <![CDATA[ Ormyrus labotus Walker (Hymenoptera: Ormyridae): another generalist that should not be a generalist is not a generalist ]]> https://biorxiv.org/content/10.1101/2021.10.26.465982v1?rss=1 Sheikh, S. I. Ward, A. K. G. Zhang, Y. M. Davis, C. K. Zhang, L. Egan, S. P. Forbes, A. A. 2021-10-28 doi:10.1101/2021.10.26.465982 Cold Spring Harbor Laboratory Press 2021-10-28 <![CDATA[ Translating outcomes from the clinical setting to preclinical models: chronic pain and functionality in chronic musculoskeletal pain ]]> https://biorxiv.org/content/10.1101/2021.10.27.466137v1?rss=1 Lenert, M. E. Gomez, R. Lane, B. T. Dailey, D. L. Vance, C. G. T. Rakel, B. A. Crofford, L. J. Sluka, K. A. Merriwether, E. N. Burton, M. D. 2021-10-29 doi:10.1101/2021.10.27.466137 Cold Spring Harbor Laboratory Press 2021-10-29 <![CDATA[ Impaired lamin localization to the nuclear envelope is responsible for nuclear damage in LMNA mutant iPSC-derived cardiomyocytes ]]> https://biorxiv.org/content/10.1101/2021.10.30.466591v1?rss=1 Maurer, M. Perati, S. Johnson, L. E. Gacita, A. M. Lai, S. Wallrath, L. L. Benjamin, I. J. McNally, E. Kirby, T. J. Lammerding, J. 2021-10-30 doi:10.1101/2021.10.30.466591 Cold Spring Harbor Laboratory Press 2021-10-30 <![CDATA[ Chronic Cochlear Implantation with and without Electric Stimulation in a Mouse Model Induces Robust Cochlear Influx of CX3CR1+/GFP Macrophages. ]]> https://biorxiv.org/content/10.1101/2021.10.31.466540v1?rss=1 Claussen, A. D. Vielman Quevedo, R. Higgins, T. Mostaert, B. Taifur Rahman, M. Kirk, J. R. Hirose, K. Hansen, M. R. 2021-11-03 doi:10.1101/2021.10.31.466540 Cold Spring Harbor Laboratory Press 2021-11-03 <![CDATA[ Cone-driven retinal responses are shaped by rod but not cone HCN1 ]]> https://biorxiv.org/content/10.1101/2021.11.03.467151v1?rss=1 View larger version (21K): org.highwire.dtl.DTLVardef@1aa760borg.highwire.dtl.DTLVardef@2be292org.highwire.dtl.DTLVardef@1280235org.highwire.dtl.DTLVardef@1a8f487_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Lankford, C. Umino, Y. Poria, D. Kefalov, V. Solessio, E. Baker, S. A. 2021-11-04 doi:10.1101/2021.11.03.467151 Cold Spring Harbor Laboratory Press 2021-11-04 <![CDATA[ Genome-wide association analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people ]]> https://biorxiv.org/content/10.1101/2021.11.04.466897v1?rss=1 Eising, E. Mirza-Schreiber, N. de Zeeuw, E. L. Wang, C. A. Truong, D. T. Allegrini, A. G. Shapland, C. Y. Zhu, G. Wigg, K. G. Gerritse, M. Molz, B. Alagoz, G. Gialluisi, A. Abbondanza, F. Rimfeld, K. Van Donkelaar, M. M. Liao, Z. Jansen, P. R. Andlauer, T. F. M. Bates, T. C. Bernard, M. Blokland, K. Borglum, A. D. Bourgeron, T. Brandeis, D. Ceroni, F. Dale, P. S. de Jong, P. F. DeFries, J. C. Demontis, D. Feng, Y. Gordon, S. D. Guger, S. L. Hayiou-Thomas, M. E. Hernandez-Cabrera, J. A. Hottenga, J.- J. Hulme, C. Kerr, E. N. Koomar, T. Landerl, K. Lovett, 2021-11-04 doi:10.1101/2021.11.04.466897 Cold Spring Harbor Laboratory Press 2021-11-04 <![CDATA[ Cooperativity mediates drug resistance and metabolism in Plasmodium falciparum malaria parasites ]]> https://biorxiv.org/content/10.1101/2021.11.05.467329v1?rss=1 Jezewski, A. J. Guggisberg, A. M. Hodge, D. M. Ghebremichael, N. McLellan, L. K. Odom John, A. R. 2021-11-06 doi:10.1101/2021.11.05.467329 Cold Spring Harbor Laboratory Press 2021-11-06 <![CDATA[ The Open Perimetry Initiative: a framework for cross-platform development for the new generation of portable perimeters ]]> https://biorxiv.org/content/10.1101/2021.11.08.467428v1?rss=1 Marin-Franch, I. Turpin, A. Artes, P. H. Chong, L. X. McKendrick, A. M. Alawa, K. A. Wall, M. 2021-11-10 doi:10.1101/2021.11.08.467428 Cold Spring Harbor Laboratory Press 2021-11-10 <![CDATA[ Pentameric assembly of the Kv2.1 tetramerization domain. ]]> https://biorxiv.org/content/10.1101/2021.11.09.467962v1?rss=1 Xu, Z. Khan, S. Schnicker, N. Baker, S. A. 2021-11-09 doi:10.1101/2021.11.09.467962 Cold Spring Harbor Laboratory Press 2021-11-09 <![CDATA[ Centrosomal Enrichment and Proteasomal Degradation of SYS-1/-β-catenin Requires the Microtubule Motor Dynein ]]> https://biorxiv.org/content/10.1101/2021.11.10.468136v1?rss=1 Thompson, J. W. Valdes Michel, M. F. Phillips, B. T. 2021-11-12 doi:10.1101/2021.11.10.468136 Cold Spring Harbor Laboratory Press 2021-11-12 <![CDATA[ Systematic assessment of lipid profiles for the discovery of tissue contributors to the circulating lipid pool in cold exposure ]]> https://biorxiv.org/content/10.1101/2021.11.12.468392v1?rss=1 Jain, R. Wade, G. Ong, I. Chaurasia, B. Simcox, J. 2021-11-12 doi:10.1101/2021.11.12.468392 Cold Spring Harbor Laboratory Press 2021-11-12 <![CDATA[ A recurrent circuit links antagonistic cerebellar modules during associative motor learning ]]> https://biorxiv.org/content/10.1101/2021.11.16.468438v1?rss=1 Ohmae, S. Ohmae, K. Heiney, S. A. Subramanian, D. Medina, J. F. 2021-11-17 doi:10.1101/2021.11.16.468438 Cold Spring Harbor Laboratory Press 2021-11-17 <![CDATA[ Aspergillus fumigatus ffmA encodes a C2H2-containing transcriptional regulator that modulates azole resistance and is required for normal growth ]]> https://biorxiv.org/content/10.1101/2021.11.17.469059v1?rss=1 Paul, S. Bowyer, P. Bromley, M. J. Moye-Rowley, W. S. 2021-11-18 doi:10.1101/2021.11.17.469059 Cold Spring Harbor Laboratory Press 2021-11-18 <![CDATA[ Cohesion in male singing behavior predicts group reproductive output in a social songbird ]]> https://biorxiv.org/content/10.1101/2021.11.20.469403v1?rss=1 Perkes, A. Schmidt, M. F. Anderson, H. L. A. Gros-Louis, J. White, D. 2021-11-20 doi:10.1101/2021.11.20.469403 Cold Spring Harbor Laboratory Press 2021-11-20 <![CDATA[ TFAP2 paralogs pioneer chromatin access for MITF and directly inhibit genes associated with cell migration ]]> https://biorxiv.org/content/10.1101/2021.11.23.469757v1?rss=1 Kenny, C. Dilshat, R. Seberg, H. Van Otterloo, E. Bonde, G. Helverson, A. Steingrimsson, E. Cornell, R. A. 2021-11-23 doi:10.1101/2021.11.23.469757 Cold Spring Harbor Laboratory Press 2021-11-23 <![CDATA[ The Importance of Mentors and How to Handle More Than One Mentor ]]> https://biorxiv.org/content/10.1101/2021.11.29.469764v1?rss=1 Marshall, A. G. Brady, L. Palavicino-Maggio, C. Neikirk, K. Vue, Z. Beasley, H. Garza Lopez, E. Murray, S. Martinez, D. Shuler, H. Spencer, E. Morton, D. Hinton, A. 2021-12-01 doi:10.1101/2021.11.29.469764 Cold Spring Harbor Laboratory Press 2021-12-01 <![CDATA[ Using a Champion-Oriented Mindset to Overcome the Challenges of Graduate School ]]> https://biorxiv.org/content/10.1101/2021.11.29.469904v1?rss=1 Marshall, A. Palavicino-Maggio, C. Neikirk, K. Vue, Z. Beasley, H. Lopez, E. G. Murray, S. A. Martinez, D. Davis, J. Shuler, H. Spencer, E. Morton, D. Hinton, A. 2021-12-01 doi:10.1101/2021.11.29.469904 Cold Spring Harbor Laboratory Press 2021-12-01 <![CDATA[ Adolescent ethanol drinking promotes hyperalgesia, neuroinflammation and serotonergic deficits in mice that persist into adulthood ]]> https://biorxiv.org/content/10.1101/2021.11.29.469930v1?rss=1 Khan, K. Bierlein-De La Rosa, G. Biggerstaff, N. Pushpavathi, S. G. Mason, S. Dailey, M. E. Marcinkiewcz, C. 2021-11-30 doi:10.1101/2021.11.29.469930 Cold Spring Harbor Laboratory Press 2021-11-30 <![CDATA[ Multivariate autoregressive model estimation for high dimensional intracranial electrophysiological data ]]> https://biorxiv.org/content/10.1101/2021.12.01.470804v1?rss=1 Endemann, C. M. Krause, B. M. Nourski, K. V. Banks, M. I. Van Veen, B. 2021-12-03 doi:10.1101/2021.12.01.470804 Cold Spring Harbor Laboratory Press 2021-12-03 <![CDATA[ Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1 ]]> https://biorxiv.org/content/10.1101/2021.12.01.470840v1?rss=1 Weaver, T. M. Click, T. H. Khoang, T. H. Washington, T. M. Agarwal, P. Freudenthal, B. D. 2021-12-01 doi:10.1101/2021.12.01.470840 Cold Spring Harbor Laboratory Press 2021-12-01 <![CDATA[ Anti-inflammatory therapy protects spiral ganglion neurons after aminoglycoside antibiotic-induced hair cell loss ]]> https://biorxiv.org/content/10.1101/2021.12.03.470945v1?rss=1 Rahman, M. T. Bailey, E. M. Gansemer, B. M. Pieper, A. A. Manak, J. R. Green, S. H. 2021-12-03 doi:10.1101/2021.12.03.470945 Cold Spring Harbor Laboratory Press 2021-12-03 <![CDATA[ Intranasal immunization with a vaccinia virus vaccine vector expressing pre-fusion stabilized SARS-CoV-2 spike fully protected mice against lethal challenge with the heavily mutated mouse-adapted SARS2-N501YMA30 strain of SARS-CoV-2 ]]> https://biorxiv.org/content/10.1101/2021.12.06.471483v1?rss=1 Kibler, K. V. Szczerba, M. Lake, D. F. Roeder, A. J. Rahman, M. Hogue, B. G. Wong, L. Y. R. Perlman, S. Li, Y. Jacobs, B. L. 2021-12-08 doi:10.1101/2021.12.06.471483 Cold Spring Harbor Laboratory Press 2021-12-08 <![CDATA[ An effective workshop on How to be an Effective Mentor for Underrepresented STEM Trainees ]]> https://biorxiv.org/content/10.1101/2021.12.06.471498v1?rss=1 Marshall, A. Vue, Z. Palavicino-Maggio, C. Spencer, E. C. Beasley, H. K. Garza Lopez, E. Conley, Z. Neikirk, K. Murray, S. A. Martinez, D. Davis, J. Brady, L. Shuler, H. D. Morton, D. Hinton, A. 2021-12-08 doi:10.1101/2021.12.06.471498 Cold Spring Harbor Laboratory Press 2021-12-08 <![CDATA[ Slit-Robo Signalling Establishes a Sphingosine-1-Phosphate Gradient to Polarise Fin Mesenchyme and Establish Fin Morphology ]]> https://biorxiv.org/content/10.1101/2021.12.07.471519v1?rss=1 Mahabaleshwar, H. P.V., A. Loo, T. Y. J. Koh, S. Y. Pitman, M. R. Kwok, S. Ma, J. Hu, B. Lin, F. Lok, X. L. Pitson, S. M. Saunders, T. E. Carney, T. J. 2021-12-07 doi:10.1101/2021.12.07.471519 Cold Spring Harbor Laboratory Press 2021-12-07 <![CDATA[ The Role of Mentoring in Promoting Diversity, Equity, and Inclusion in STEM Education and Research ]]> https://biorxiv.org/content/10.1101/2021.12.08.471502v1?rss=1 Marshall, A. Vue, Z. Palavicino-maggio, C. Spencer, E. C. Beasley, H. K. Garza- Lopez, E. Conley, Z. Neikirk, K. Murray, S. A. Martinez, D. Davis, J. Brady, L. J. Shuler, H. D. Morton, D. Hinton, A. 2021-12-09 doi:10.1101/2021.12.08.471502 Cold Spring Harbor Laboratory Press 2021-12-09 <![CDATA[ Lipid hydroperoxides promote muscle atrophy through lysosomal amplification ]]> https://biorxiv.org/content/10.1101/2021.12.17.473200v1?rss=1 Eshima, H. Siripoksup, P. Shahtout, J. L. Pearson, M. J. Mahmassani, Z. S. Ferrara, P. J. Lyons, A. W. Maschek, J. A. Peterlin, A. D. Verkerke, A. R. P. Johnson, J. M. Salcedo, A. Petrocelli, J. J. Anderson, E. J. Boudina, S. Ran, Q. Cox, J. E. Drummond, M. J. Funai, K. 2021-12-20 doi:10.1101/2021.12.17.473200 Cold Spring Harbor Laboratory Press 2021-12-20 <![CDATA[ MERS-CoV endoribonuclease and accessory proteins jointly evade host innate immunity during infection of lung and nasal epithelial cells ]]> https://biorxiv.org/content/10.1101/2021.12.20.473564v1?rss=1 Comar, C. Otter, C. Pfannenstiel, J. Doerger, E. Renner, D. Tan, L. H. Perlman, S. Cohen, N. Fehr, A. Weiss, S. R. 2021-12-21 doi:10.1101/2021.12.20.473564 Cold Spring Harbor Laboratory Press 2021-12-21 <![CDATA[ Liquid-liquid phase separation facilitates the biogenesis of secretory storage granules ]]> https://biorxiv.org/content/10.1101/2021.12.22.472607v1?rss=1 PARCHURE, A. Tian, M. Boyer, C. K. Bearrows, S. C. Rohli, K. E. Zhang, J. Ramazanov, B. R. Wang, Y. Stephens, S. von Blume, J. 2021-12-23 doi:10.1101/2021.12.22.472607 Cold Spring Harbor Laboratory Press 2021-12-23 <![CDATA[ Quantifying the inverted U: A meta-analysis of prefrontal dopamine, D1-receptors, and working memory ]]> https://biorxiv.org/content/10.1101/2021.12.22.473899v1?rss=1 Weber, M. A. Conlon, M. M. Stutt, H. R. Wendt, L. Ten Eyck, P. Narayanan, N. S. 2021-12-23 doi:10.1101/2021.12.22.473899 Cold Spring Harbor Laboratory Press 2021-12-23 <![CDATA[ Nuclear localization and transactivation of SYS-1/β-catenin is the result of serial gene duplications and subfunctionalizations ]]> https://biorxiv.org/content/10.1101/2021.12.26.473689v1?rss=1 Wolf, A. K. Adams-Phillips, L. C. Adams, A. N. D. Erives, A. J. Phillips, B. T. 2021-12-27 doi:10.1101/2021.12.26.473689 Cold Spring Harbor Laboratory Press 2021-12-27 <![CDATA[ Single Nuclei Transcriptome Reveals Perturbed Brain Vascular Molecules in Alzheimer's Disease ]]> https://biorxiv.org/content/10.1101/2021.12.28.474255v1?rss=1 View larger version (38K): org.highwire.dtl.DTLVardef@f48748org.highwire.dtl.DTLVardef@1ddc3f4org.highwire.dtl.DTLVardef@6bfa5eorg.highwire.dtl.DTLVardef@1024506_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Is, O. Wang, X. Patel, T. A. Quicksall, Z. S. Heckman, M. G. White, L. J. Lewis-Tuffin, L. J. Deniz, K. Tutor-New, F. Q. Carnwath, T. P. Min, Y. Oatman, S. R. Reddy, J. S. Carrasquillo, M. M. Nguyen, T. T. Ho, C. C. G. Malphrus, K. G. Nho, K. Murray, M. E. Dickson, D. W. Saykin, A. J. Allen, M. Ertekin-Taner, N. 2021-12-29 doi:10.1101/2021.12.28.474255 Cold Spring Harbor Laboratory Press 2021-12-29 <![CDATA[ Roles for Mitochondrial Complex I subunits in regulating synaptic transmission and growth ]]> https://biorxiv.org/content/10.1101/2021.12.30.474605v1?rss=1 Mallik, B. Frank, C. A. 2022-01-01 doi:10.1101/2021.12.30.474605 Cold Spring Harbor Laboratory Press 2022-01-01 <![CDATA[ DRP1-mediated mitochondrial fission is essential to maintain cristae morphology and bioenergetics ]]> https://biorxiv.org/content/10.1101/2021.12.31.474637v1?rss=1 Robertson, G. L. Riffle, S. Patel, M. Marshall, A. Beasley, H. Garza-Lopez, E. Shao, J. Vue, Z. Hinton, A. Mears, J. Gama, V. 2022-01-03 doi:10.1101/2021.12.31.474637 Cold Spring Harbor Laboratory Press 2022-01-03 <![CDATA[ Abnormal larval neuromuscular junction morphology and physiology in Drosophila Prickle isoform mutants with defective axonal transport and adult seizure behavior ]]> https://biorxiv.org/content/10.1101/2021.12.31.474668v1?rss=1 O'Harrow, T. Ueda, A. Xing, X. Ehaideb, S. N. Manak, J. R. Wu, C.-F. 2022-01-02 doi:10.1101/2021.12.31.474668 Cold Spring Harbor Laboratory Press 2022-01-02 <![CDATA[ Metabolic rescue ameliorates mitochondrial encephalo-cardiomyopathy in murine and human iPSC models of Leigh syndrome ]]> https://biorxiv.org/content/10.1101/2022.01.04.475008v1?rss=1 Yoon, J.-Y. Daneshgar, N. Chu, Y. Chen, B. Hefti, M. Irani, K. Song, L.-S. Brenner, C. Abel, E. D. London, B. Dai, D.-F. 2022-01-05 doi:10.1101/2022.01.04.475008 Cold Spring Harbor Laboratory Press 2022-01-05 <![CDATA[ unc-37/Groucho and lsy-22/AES repress Wnt target genes in C. elegans asymmetric cell divisions ]]> https://biorxiv.org/content/10.1101/2022.01.10.475695v1?rss=1 Bekas, K. N. Phillips, B. T. 2022-01-11 doi:10.1101/2022.01.10.475695 Cold Spring Harbor Laboratory Press 2022-01-11 <![CDATA[ The dorsal hippocampus' role in context-based timing in rodents ]]> https://biorxiv.org/content/10.1101/2022.01.10.475732v1?rss=1 De Corte, B. J. Farley, S. J. Heslin, K. A. Parker, K. L. Freeman, J. H. 2022-01-11 doi:10.1101/2022.01.10.475732 Cold Spring Harbor Laboratory Press 2022-01-11 <![CDATA[ The voltage-gated Cav Ca2+ channel subunit α2δ-4 is required for locomotor behavior and sensorimotor gating in mice ]]> https://biorxiv.org/content/10.1101/2022.01.17.476669v1?rss=1 Klomp, A. Lee, A. Omichi, R. Iwasa, Y. Smith, R. Usachev, Y. Russo, A. Narayanan, N. 2022-01-17 doi:10.1101/2022.01.17.476669 Cold Spring Harbor Laboratory Press 2022-01-17 <![CDATA[ Effects of transcranial magnetic stimulation on the human brain recorded with intracranial electrocorticography: First-in-human study ]]> https://biorxiv.org/content/10.1101/2022.01.18.476811v1?rss=1 Wang, J. B. Bruss, J. Oya, H. Uitermarkt, B. D. Trapp, N. T. Gander, P. E. Howard, M. A. Keller, C. J. Boes, A. 2022-01-21 doi:10.1101/2022.01.18.476811 Cold Spring Harbor Laboratory Press 2022-01-21 <![CDATA[ Knockout of Bbs10 results in lack of cone electrical function and progressive retinal degeneration of rods and cones ]]> https://biorxiv.org/content/10.1101/2022.01.19.476952v1?rss=1 Mayer, S. K. Thomas, J. Helms, M. Kothapalli, A. K. Cherascu, I. Stalter, E. Wang, K. Datta, P. Searby, C. Seo, S. Hsu, Y. Bhattarai, S. Sheffield, V. C. Drack, A. V. 2022-01-21 doi:10.1101/2022.01.19.476952 Cold Spring Harbor Laboratory Press 2022-01-21 <![CDATA[ Tonic GluD1 channel current is independent of G protein activity in the dorsal raphe nucleus ]]> https://biorxiv.org/content/10.1101/2022.01.20.477055v1?rss=1 Copeland, D. S. Gantz, S. C. 2022-01-22 doi:10.1101/2022.01.20.477055 Cold Spring Harbor Laboratory Press 2022-01-22 <![CDATA[ Delimiting the cryptic diversity and host preferences of Sycophila parasitoid wasps associated with oak galls using phylogenomic data ]]> https://biorxiv.org/content/10.1101/2022.01.21.477213v1?rss=1 Zhang, Y. M. Sheikh, S. Ward, A. K. G. Forbes, A. A. Prior, K. Stone, G. N. Gates, M. Egan, S. Zhang, L. N. Davis, C. Weinersmith, K. Melika, G. Lucky, A. 2022-01-23 doi:10.1101/2022.01.21.477213 Cold Spring Harbor Laboratory Press 2022-01-23 <![CDATA[ CGRP Administration into the Cerebellum Evokes Migraine-like Behaviors Predominately in Female Mice ]]> https://biorxiv.org/content/10.1101/2022.01.24.477577v1?rss=1 Wang, M. Duong, T. Rea, B. Waite, J. Huebner, M. Flinn, H. Russo, A. Sowers, L. P. 2022-01-26 doi:10.1101/2022.01.24.477577 Cold Spring Harbor Laboratory Press 2022-01-26 <![CDATA[ Genetic modifiers of Cep290-mediated retinal degeneration ]]> https://biorxiv.org/content/10.1101/2022.01.26.477596v1?rss=1 Meyer, K. J. Whitmore, S. S. Burnight, E. R. Riker, M. Mercer, H. E. Oladele-Ajose, A. Howell, G. Stone, E. M. Mullins, R. F. Tucker, B. A. Scheetz, T. E. Anderson, M. G. 2022-01-28 doi:10.1101/2022.01.26.477596 Cold Spring Harbor Laboratory Press 2022-01-28 <![CDATA[ Complex and critical roles for the AtrR transcription factor in control of cyp51A expression in Aspergillus fumigatus ]]> https://biorxiv.org/content/10.1101/2022.01.28.478276v1?rss=1 Paul, S. Verweij, P. E. Melchers, W. J. G. Moye-Rowley, W. S. 2022-01-29 doi:10.1101/2022.01.28.478276 Cold Spring Harbor Laboratory Press 2022-01-29 <![CDATA[ A New Classification Method Based on Dynamic Ensemble Selection and its Application to Predict Variance Patterns in HIV-1 Env ]]> https://biorxiv.org/content/10.1101/2022.01.31.478521v1?rss=1 Fili, M. Hu, G. Han, C. Kort, A. Trettin, J. Haim, H. 2022-02-02 doi:10.1101/2022.01.31.478521 Cold Spring Harbor Laboratory Press 2022-02-02 <![CDATA[ Patterns of Volatility Across the Spike Protein Accurately Predict the Emergence of Mutations within SARS-CoV-2 Lineages ]]> https://biorxiv.org/content/10.1101/2022.02.01.478697v1?rss=1 Rojas Chavez, R. A. Fili, M. Han, C. Rahman, S. A. Bicar, I. G. L. Hu, G. Das, J. Brown, G. D. Haim, H. 2022-02-02 doi:10.1101/2022.02.01.478697 Cold Spring Harbor Laboratory Press 2022-02-02 <![CDATA[ Maternal Wnt11b regulates cortical rotation during Xenopus axis formation: analysis of maternal-effect wnt11b mutants ]]> https://biorxiv.org/content/10.1101/2022.02.02.478872v1?rss=1 Houston, D. W. Elliott, K. L. Coppenrath, K. Wlizla, M. Horb, M. E. 2022-02-04 doi:10.1101/2022.02.02.478872 Cold Spring Harbor Laboratory Press 2022-02-04 <![CDATA[ Blocking Gi/o-coupled signaling eradicates cancer stem cells and sensitizes breast tumors to HER2-targeted therapies to inhibit tumor relapse ]]> https://biorxiv.org/content/10.1101/2022.02.05.479272v1?rss=1 Lyu, C. Ye, Y. Weigel, R. J. Chen, S. 2022-02-08 doi:10.1101/2022.02.05.479272 Cold Spring Harbor Laboratory Press 2022-02-08 <![CDATA[ Functional geometry of auditory cortical resting state networks derived from intracranial electrophysiology ]]> https://biorxiv.org/content/10.1101/2022.02.06.479292v1?rss=1 Banks, M. I. Krause, B. M. Berger, D. G. Campbell, D. I. Boes, A. D. Bruss, J. E. Kovach, C. K. Kawasaki, H. Steinschneider, M. Nourski, K. V. 2022-02-09 doi:10.1101/2022.02.06.479292 Cold Spring Harbor Laboratory Press 2022-02-09 <![CDATA[ Parallel Expansion and Divergence of the Hyr/Iff-like (Hil) Adhesin Family in Pathogenic Yeasts Including Candida auris ]]> https://biorxiv.org/content/10.1101/2022.02.09.479577v1?rss=1 He, B. Z. Fassler, J. S. Snyder, L. F. Smoak, R. 2022-02-10 doi:10.1101/2022.02.09.479577 Cold Spring Harbor Laboratory Press 2022-02-10 <![CDATA[ A systems biology approach to elucidate the post-translational regulome of coronary artery disease ]]> https://biorxiv.org/content/10.1101/2022.02.09.479759v1?rss=1 Sharma, A. Ghatge, M. Deshpande, V. Vangala, R. k. 2022-02-10 doi:10.1101/2022.02.09.479759 Cold Spring Harbor Laboratory Press 2022-02-10 <![CDATA[ Meiotic, genomic and evolutionary properties of crossover distribution in Drosophila yakuba ]]> https://biorxiv.org/content/10.1101/2022.02.10.479767v1?rss=1 Pettie, N. Llopart, A. Comeron, J. 2022-02-10 doi:10.1101/2022.02.10.479767 Cold Spring Harbor Laboratory Press 2022-02-10 <![CDATA[ Increased prevalence of a frontoparietal brain state at rest is associated with better motor recovery in individuals with pontine stroke affecting dominant-hand corticospinal tract ]]> https://biorxiv.org/content/10.1101/2022.02.10.479962v1?rss=1 Olafson, E. Russello, G. Jamison, K. W. Liu, H. Wang, D. Bruss, J. Boes, A. Kuceyeski, A. 2022-02-11 doi:10.1101/2022.02.10.479962 Cold Spring Harbor Laboratory Press 2022-02-11 <![CDATA[ Speciation in Nearctic oak gall wasps is frequently correlated with changes in host plant, host organ, or both. ]]> https://biorxiv.org/content/10.1101/2022.02.11.480154v1?rss=1 1000 Ultra Conserved Elements (UCEs) and flanking sequences to infer wasp phylogenies. We assessed the relationships of Nearctic gall wasps to one another and, by leveraging previously published UCE data, to the Palearctic fauna. We then used phylogenies to infer historical patterns of shifts among host tree species and tree organs. Our results indicate that oak gall wasps have moved between the Palearctic and Nearctic at least four times, that some Palearctic clades have their proximate origin in the Nearctic, and that gall wasps have shifted within and between oak tree sections, subsections, and organs considerably more often than the analysis of previous data have suggested. Given that host shifts have been demonstrated to drive reproductive isolation between host-associated populations in other phytophagous insects, our analyses of Nearctic gall wasps suggest that host shifts are key drivers of speciation in this clade, especially in hotspots of oak diversity. Though formal assessment of this hypothesis requires further study, two putatively oligophagous gall wasp species in our dataset show signals of host-associated genetic differentiation unconfounded by geographic distance, suggestive of barriers to gene flow associated with the use of alternative host plants. ]]> Ward, A. K. G. Bagley, R. K. Egan, S. P. Hood, G. R. Ott, J. R. Prior, K. M. Sheikh, S. I. Weinersmith, K. L. Zhang, L. Zhang, Y. M. Forbes, A. A. 2022-02-13 doi:10.1101/2022.02.11.480154 Cold Spring Harbor Laboratory Press 2022-02-13 <![CDATA[ Knockout of Sorbs2 in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice ]]> https://biorxiv.org/content/10.1101/2022.02.13.480093v1?rss=1 McLendon, J. M. Zhang, X. Matasic, D. Kumar, M. Koval, O. M. Grumbach, I. M. Sadayappan, S. London, B. Boudreau, R. 2022-02-13 doi:10.1101/2022.02.13.480093 Cold Spring Harbor Laboratory Press 2022-02-13 <![CDATA[ Myelin lipids as nervous system energy reserves ]]> https://biorxiv.org/content/10.1101/2022.02.24.481621v1?rss=1 Asadollahi, E. Trevisiol, A. Saab, A. S. Looser, Z. J. Dibaj, P. Kusch, K. Ruhwedel, T. Moebius, W. Jahn, O. Baes, M. Weber, B. Abel, E. D. Ballabio, A. Popko, B. Kassmann, C. M. Ehrenreich, H. Hirrlinger, J. Nave, K.-A. 2022-02-25 doi:10.1101/2022.02.24.481621 Cold Spring Harbor Laboratory Press 2022-02-25 <![CDATA[ "Transposon Mutagenesis Reveals RBMS3 as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis." ]]> https://biorxiv.org/content/10.1101/2022.02.28.482366v1?rss=1 CTNNB1>c-MYC pathway. Finally, analyses of patient samples in The Cancer Genome Atlas (TCGA) revealed that the region of chromosome 3 encompassing RBMS3 is frequently lost in NSCLC and correlates with poor patient prognosis. Collectively, SB-mediated transposon mutagenesis has revealed the ability of a novel tumor suppressor, RBMS3, to cooperate with BRAFV600E to promote lung carcinogenesis, and suggests that RBMS3 silencing may contribute to malignant progression of numerous human lung cancers. SIGNIFICANCEThe BRAFV600E oncoprotein kinase is a potent initiator of benign lung tumorigenesis, but is insufficient to elicit malignant lung adenocarcinoma without additional cooperating alterations. Sleeping Beauty-mediated transposon mutagenesis has revealed a number of genes that cooperate with BRAFV600E to promote lung cancer progression, in particular Rbms3, which encodes an RNA binding protein. Hence, this genetic screen provides a deeper understanding of the molecular mechanisms underlying BRAFV600E-driven lung carcinogenesis, and is an important step improving our ability to successfully target this disease. ]]> Vaishnavi, A. Juan, J. Scherzer, M. T. VanVeen, J. E. Stehn, C. Hackett, C. S. Dupuy, A. Chmura, S. A. van der Weyden, L. Newberg, J. Y. Mann, K. M. Liu, A. Rust, A. G. Weiss, W. A. Adams, D. Grossman, A. Mann, M. B. McMahon, M. 2022-02-28 doi:10.1101/2022.02.28.482366 Cold Spring Harbor Laboratory Press 2022-02-28 <![CDATA[ Promising Antimalarials targeting Apicoplast DNA Polymerase from Plasmodium falciparum ]]> https://biorxiv.org/content/10.1101/2022.03.07.483284v1?rss=1 Cheda, P. Nieto, N. Kaur, S. Beck, J. M. Beck, J. R. Kerns, R. Honzatko, R. B. Nelson, S. W. 2022-03-07 doi:10.1101/2022.03.07.483284 Cold Spring Harbor Laboratory Press 2022-03-07 <![CDATA[ Lingering neural representations of past task features adversely affect future behavior ]]> https://biorxiv.org/content/10.1101/2022.03.08.483546v1?rss=1 Rangel, B. O. Hazeltine, E. Wessel, J. R. 2022-03-10 doi:10.1101/2022.03.08.483546 Cold Spring Harbor Laboratory Press 2022-03-10 <![CDATA[ Structural basis for APE1 processing DNA damage in the nucleosome ]]> https://biorxiv.org/content/10.1101/2022.03.09.483662v1?rss=1 Weaver, T. M. Hoitsma, N. M. Spencer, J. J. Freudenthal, B. D. Gakhar, L. Schnicker, N. J. 2022-03-10 doi:10.1101/2022.03.09.483662 Cold Spring Harbor Laboratory Press 2022-03-10 <![CDATA[ Genetic interaction analysis reveals that Cryptococcus neoformans utilizes multiple acetyl-CoA-generating pathways during infection ]]> https://biorxiv.org/content/10.1101/2022.03.16.484561v1?rss=1 Alden, K. M. Jezewski, A. J. Beattie, S. R. Fox, D. Krysan, D. J. 2022-03-16 doi:10.1101/2022.03.16.484561 Cold Spring Harbor Laboratory Press 2022-03-16 <![CDATA[ Glucagon Receptor Signaling at White Adipose Tissue Does Not Regulate Lipolysis ]]> https://biorxiv.org/content/10.1101/2022.03.20.485051v1?rss=1 Vasileva, A. Marx, T. J. Beaudry, J. Stern, J. H. 2022-03-21 doi:10.1101/2022.03.20.485051 Cold Spring Harbor Laboratory Press 2022-03-21 <![CDATA[ HSV Tegument Protein pUL51 Interacts with Host Dynactin for Viral Spread ]]> https://biorxiv.org/content/10.1101/2022.03.21.485087v1?rss=1 White, S. Tran, M. Roller, R. 2022-03-21 doi:10.1101/2022.03.21.485087 Cold Spring Harbor Laboratory Press 2022-03-21 <![CDATA[ 3D Reconstructions of Mouse Skeletal Muscle and Heart Muscle Reveal a Decrease in the MICOS Complex and Altered Mitochondrial Networks ]]> https://biorxiv.org/content/10.1101/2022.03.22.485341v1?rss=1 Vue, Z. Lopez, E. G. Neikirk, K. Vang, L. Beasley, H. Marshall, A. Hinton, A. 2022-03-23 doi:10.1101/2022.03.22.485341 Cold Spring Harbor Laboratory Press 2022-03-23 <![CDATA[ Hypomorphism of a novel long ERα isoform causes severe reproductive dysfunctions in female mice ]]> https://biorxiv.org/content/10.1101/2022.03.22.485385v1?rss=1 Saito, K. Dickey, J. E. Rodeghiero, S. R. Toth, B. A. Kelly, M. J. Deng, Y. Singh, U. Deng, G. Jiang, J. Cui, H. 2022-03-26 doi:10.1101/2022.03.22.485385 Cold Spring Harbor Laboratory Press 2022-03-26 <![CDATA[ The gender gap in academic career achievements and the mediation effect of work-family conflict and partner support ]]> https://biorxiv.org/content/10.1101/2022.03.23.485507v1?rss=1 Zheng, X. Yuan, H. Ni, C. 2022-03-25 doi:10.1101/2022.03.23.485507 Cold Spring Harbor Laboratory Press 2022-03-25 <![CDATA[ FKS1 is required for Cryptococcus neoformans fitness in vivo: application of copper-regulated gene expression to mouse models of cryptococcosis ]]> https://biorxiv.org/content/10.1101/2022.03.24.485727v1?rss=1 Beattie, S. R. Jezewski, A. Ristow, L. C. Wellington, M. Krysan, D. J. 2022-03-25 doi:10.1101/2022.03.24.485727 Cold Spring Harbor Laboratory Press 2022-03-25 <![CDATA[ Sex and genetic specific effects on behavioral, but not metabolic, responses to a high fat diet in heterogeneous stock rats ]]> https://biorxiv.org/content/10.1101/2022.03.25.485743v1?rss=1 Deal, A. W. Thurman, A. Seshie, O. Szalanczy, A. Beeson, A. Cockerham, M. Risemberg, E. L. Lenzo, A. Ozimek, N. Langefeld, C. Valdar, W. Solberg Woods, L. C. 2022-03-25 doi:10.1101/2022.03.25.485743 Cold Spring Harbor Laboratory Press 2022-03-25 <![CDATA[ Candida albicans filamentation does not require the cAMP-PKA pathway in vivo ]]> https://biorxiv.org/content/10.1101/2022.03.25.485899v1?rss=1 Wakade, R. S. Kamara, J. Wellington, M. Krysan, D. J. 2022-03-26 doi:10.1101/2022.03.25.485899 Cold Spring Harbor Laboratory Press 2022-03-26 <![CDATA[ Repeated ethanol exposure and withdrawal alters ACE2 expression in discrete brain regions: Implications for SARS-CoV-2 infection ]]> https://biorxiv.org/content/10.1101/2022.03.29.486282v1?rss=1 Balasubramanian, N. James, T. D. Pushpavathi, S. G. Marcinkiewcz, C. A. 2022-03-29 doi:10.1101/2022.03.29.486282 Cold Spring Harbor Laboratory Press 2022-03-29 <![CDATA[ The WalRK Two-component system is Essential for Proper Cell Envelope Biogenesis in Clostridioides difficile ]]> https://biorxiv.org/content/10.1101/2022.04.01.486798v1?rss=1 Muh, U. Ellermeier, C. D. Weiss, D. S. 2022-04-02 doi:10.1101/2022.04.01.486798 Cold Spring Harbor Laboratory Press 2022-04-02 <![CDATA[ Behavioral dysregulation and monoaminergic deficits precede memory impairments in human tau-overexpressing (htau) mice ]]> https://biorxiv.org/content/10.1101/2022.04.03.486898v1?rss=1 Khan, K. M. Selvakumar, G. P. Balasubramanian, N. Wang, R. Pierson, S. Hefti, M. Marcinkiewcz, C. A. 2022-04-05 doi:10.1101/2022.04.03.486898 Cold Spring Harbor Laboratory Press 2022-04-05 <![CDATA[ Mice expressing P301S mutant human tau have deficits in interval timing ]]> https://biorxiv.org/content/10.1101/2022.04.04.487032v1?rss=1 Khandelwal, V. Larson, T. Weber, M. A. Leidinger, M. R. Meyerholz, D. K. Narayanan, N. Zhang, Q. 2022-04-05 doi:10.1101/2022.04.04.487032 Cold Spring Harbor Laboratory Press 2022-04-05 <![CDATA[ NEUROeSTIMator: Using Deep Learning to Quantify Neuronal Activation from Single-Cell and Spatial Transcriptomic Data ]]> https://biorxiv.org/content/10.1101/2022.04.08.487573v1?rss=1 Bahl, E. Chatterjee, S. Elsadany, M. Vanrobaeys, Y. Lin, L.-C. Giese, K. P. Abel, T. Michaelson, J. 2022-04-10 doi:10.1101/2022.04.08.487573 Cold Spring Harbor Laboratory Press 2022-04-10 <![CDATA[ Tuning aromatic contributions by site-specific encoding of fluorinated phenylalanine residues in bacterial and mammalian cells ]]> https://biorxiv.org/content/10.1101/2022.04.12.488046v1?rss=1 Galles, G. D. Infield, D. T. Clark, C. J. Manikandan, S. Rasouli, A. Tajkhorshid, E. Galpin, J. D. Cooley, R. B. Mehl, R. A. Ahern, C. A. 2022-04-12 doi:10.1101/2022.04.12.488046 Cold Spring Harbor Laboratory Press 2022-04-12 <![CDATA[ Representational integration and differentiation in the human hippocampus following goal-directed navigation ]]> https://biorxiv.org/content/10.1101/2022.04.12.488078v1?rss=1 Fernandez, C. Jiang, J. Wang, S.-F. Choi, H. Wagner, A. D. 2022-04-13 doi:10.1101/2022.04.12.488078 Cold Spring Harbor Laboratory Press 2022-04-13 <![CDATA[ Immediate neural network impact after the loss of a semantic hub ]]> https://biorxiv.org/content/10.1101/2022.04.15.488388v1?rss=1 Kocsis, Z. Jenison, R. L. Cope, T. E. Taylor, P. N. Calmus, R. M. McMurray, B. Rhone, A. E. Sarrett, M. E. Kikuchi, Y. Gander, P. E. Berger, J. I. Kovach, C. K. Choi, I. Greenlee, J. D. Kawasaki, H. Griffiths, T. D. Howard, M. A. Petkov, C. I. 2022-04-16 doi:10.1101/2022.04.15.488388 Cold Spring Harbor Laboratory Press 2022-04-16 <![CDATA[ Vegetation formation in Staphylococcus aureus endocarditis inversely correlates with RNAIII and sarA expression in invasive clonal complex 5 (CC5) isolates ]]> https://biorxiv.org/content/10.1101/2022.04.20.488955v1?rss=1 Kinney, K. J. Stach, J. M. Kulhankova, K. Brown, M. Salgado-Pabon, W. 2022-04-20 doi:10.1101/2022.04.20.488955 Cold Spring Harbor Laboratory Press 2022-04-20 <![CDATA[ IL-17A controls CNS autoimmunity by regulating gut microbiota and inducing regulatory T cells ]]> https://biorxiv.org/content/10.1101/2022.04.22.489206v1?rss=1 Shahi, S. K. Ghimire, S. Jensen, S. N. Lehman, P. Borcherding, N. Gibson-Corley, K. Ganesan, S. M. Karandikar, N. J. Mangalam, A. K. 2022-04-22 doi:10.1101/2022.04.22.489206 Cold Spring Harbor Laboratory Press 2022-04-22 <![CDATA[ MICOS Complex and Mitochondria Morphology Changes Across Aging in Cardiac Muscle ]]> https://biorxiv.org/content/10.1101/2022.04.23.489291v1?rss=1 Vue, Z. Garza Lopez, E. Neikirk, K. Vang, L. Beasley, H. Crabtree, A. Marshall, A. Murray, S. A. Hinton, A. 2022-04-24 doi:10.1101/2022.04.23.489291 Cold Spring Harbor Laboratory Press 2022-04-24 <![CDATA[ The arthropod associates of 155 North American cynipid oak galls ]]> https://biorxiv.org/content/10.1101/2022.04.26.489445v1?rss=1 Ward, A. K. G. Busbee, R. W. Chen, R. A. Davis, C. K. Driscoe, A. L. Egan, S. P. Goldberg, B. A. Hood, G. R. Jones, D. Kranz, A. J. Meadley-Dunphy, S. A. Milks, A. K. Ott, J. R. Prior, K. M. Sheikh, S. I. Shzu, S. Weinersmith, K. L. Zhang, L. Zhang, Y. M. Forbes, A. A. 2022-04-27 doi:10.1101/2022.04.26.489445 Cold Spring Harbor Laboratory Press 2022-04-27 <![CDATA[ Visualizing the Coordination of APE1 and DNA Polymerase β During Base Excision Repair ]]> https://biorxiv.org/content/10.1101/2022.05.02.490312v1?rss=1 Fairlamb, M. Washington, T. Freudenthal, B. D. 2022-05-02 doi:10.1101/2022.05.02.490312 Cold Spring Harbor Laboratory Press 2022-05-02 <![CDATA[ Right inferior frontal cortex damage impairs the initiation of inhibitory control, but not its implementation ]]> https://biorxiv.org/content/10.1101/2022.05.03.490498v1?rss=1 Choo, Y. Matzke, D. Bowren, M. Tranel, D. Wessel, J. R. 2022-05-04 doi:10.1101/2022.05.03.490498 Cold Spring Harbor Laboratory Press 2022-05-04 <![CDATA[ Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel ]]> https://biorxiv.org/content/10.1101/2022.05.10.491345v1?rss=1 Strege, P. R. Cowan, L. M. Alcaino, C. Mazzone, A. Ahern, C. A. Milescu, L. S. Farrugia, G. Beyder, A. 2022-05-10 doi:10.1101/2022.05.10.491345 Cold Spring Harbor Laboratory Press 2022-05-10 <![CDATA[ Structure and mechanism of LARGE1 matriglycan polymerase ]]> https://biorxiv.org/content/10.1101/2022.05.12.491222v1?rss=1 Joseph, S. Schnicker, N. J. Xu, Z. Yang, T. Hopkins, J. Watkins, M. Chakravarthy, S. Davulcu, O. Anderson, M. E. Venzke, D. Campbell, K. P. 2022-05-12 doi:10.1101/2022.05.12.491222 Cold Spring Harbor Laboratory Press 2022-05-12 <![CDATA[ All Staphylococcus aureus bacteraemia strains have the potential to cause infective endocarditis: results of GWAS and experimental animal studies ]]> https://biorxiv.org/content/10.1101/2022.05.16.491111v1?rss=1 Bastien, S. Meyers, S. Salgado-Pabon, W. Giulieri, S. Rasigade, J.-P. Liesenborghs, L. Kinney, K. J. Couzon, F. Martin-Simoes, P. Le Moing, V. Duval, X. M. Holmes, N. E. Bruun, N. E. Skov, R. Howden, B. P. Fowler, V. G. Verhamme, P. Andersen, P. S. Bouchiat, C. Moreau, K. Vandenesch, F. 2022-05-17 doi:10.1101/2022.05.16.491111 Cold Spring Harbor Laboratory Press 2022-05-17 <![CDATA[ Stronger sexual dimorphism in fruit flies may be favored when congeners are present and females actively search for mates ]]> https://biorxiv.org/content/10.1101/2022.05.17.492314v1?rss=1 Hippee, A. C. Beer, M. A. Norrbom, A. L. Forbes, A. A. 2022-05-19 doi:10.1101/2022.05.17.492314 Cold Spring Harbor Laboratory Press 2022-05-19 <![CDATA[ Variational and phase response analysis for limit cycles with hard boundaries, with applications to neuromechanical control problems ]]> https://biorxiv.org/content/10.1101/2022.05.17.492350v1?rss=1 Wang, Y. Gill, J. P. Chiel, H. J. Thomas, P. J. 2022-05-20 doi:10.1101/2022.05.17.492350 Cold Spring Harbor Laboratory Press 2022-05-20 <![CDATA[ A critical role for touch neurons in a skin-brain pathway for stress resilience ]]> https://biorxiv.org/content/10.1101/2022.05.23.493062v1?rss=1 Schaffler, M. D. Johnson, M. Hing, B. Kahler, P. Hultman, I. Srivastava, S. Arnold, J. Blendy, J. N. Hultman, R. Abdus-Saboor, I. 2022-05-23 doi:10.1101/2022.05.23.493062 Cold Spring Harbor Laboratory Press 2022-05-23 <![CDATA[ Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons ]]> https://biorxiv.org/content/10.1101/2022.05.24.493086v1?rss=1 Popova, D. Gameiro-Ros, I. Youssef, M. M. Zalamea, P. Morris, A. D. Prytkova, I. Jadali, A. Kwan, K. Y. Kamarajan, C. Salvatore, J. E. Edenberg, H. J. Xuei, X. Chorlian, D. B. Porjesz, B. Kuperman, S. Dick, D. M. Goate, A. Tischfield, J. A. Pang, Z. P. Slesinger, P. A. Hart, R. P. 2022-05-24 doi:10.1101/2022.05.24.493086 Cold Spring Harbor Laboratory Press 2022-05-24 <![CDATA[ Lesion Localization of Time Disorientation in Patients With Focal Brain Damage ]]> https://biorxiv.org/content/10.1101/2022.05.24.493338v1?rss=1 Skye, J. Bruss, J. Herbet, G. Tranel, D. Boes, A. D. 2022-05-26 doi:10.1101/2022.05.24.493338 Cold Spring Harbor Laboratory Press 2022-05-26 <![CDATA[ γ-Protocadherins control synapse formation and peripheral branching of touch sensory neurons ]]> https://biorxiv.org/content/10.1101/2022.05.25.493080v1?rss=1 Meltzer, S. Comeau, K. Chirila, A. Osei-Asante, E. DeLisle, M. Zhang, Q. Kalish, B. T. Tasnim, A. Huey, E. Fuller, L. C. Flaherty, E. K. Lefebvre, J. L. Maniatis, T. Garrett, A. M. Weiner, J. A. Ginty, D. D. 2022-05-25 doi:10.1101/2022.05.25.493080 Cold Spring Harbor Laboratory Press 2022-05-25 <![CDATA[ A humanized yeast model reveals dominant-negative properties of neuropathy-associated alanyl-tRNA synthetase mutations ]]> https://biorxiv.org/content/10.1101/2022.05.25.493316v1?rss=1 Meyer-Schuman, R. Marte, S. Smith, T. Feely, S. M. E. Kennerson, M. Nicholson, G. Shy, M. E. Koutmou, K. Antonellis, A. 2022-05-25 doi:10.1101/2022.05.25.493316 Cold Spring Harbor Laboratory Press 2022-05-25 <![CDATA[ The outer surface protease, SepM, is required for blp locus activation in three of the four most common pherotypes of Streptococcus pneumoniae. ]]> https://biorxiv.org/content/10.1101/2022.05.27.493805v1?rss=1 Ratner, S. Bollinger, K. Richardson, J. Dawid, S. 2022-05-28 doi:10.1101/2022.05.27.493805 Cold Spring Harbor Laboratory Press 2022-05-28 <![CDATA[ Language exposure and brain myelination in early development ]]> https://biorxiv.org/content/10.1101/2022.05.31.493945v1?rss=1 Fibla, L. Forbes, S. H. McCarthy, J. Mee, K. Magnotta, V. A. Deoni, S. Cameron, D. Spencer, J. P. 2022-06-02 doi:10.1101/2022.05.31.493945 Cold Spring Harbor Laboratory Press 2022-06-02 <![CDATA[ Mouse tissue harvest-induced hypoxia rapidly alters the in vivo metabolome, between-genotype metabolite level differences, and 13C-tracing enrichments ]]> https://biorxiv.org/content/10.1101/2022.06.07.495179v1?rss=1 Rauckhorst, A. J. Borcherding, N. Pape, D. J. Kraus, A. S. Scerbo, D. A. Taylor, E. B. 2022-06-08 doi:10.1101/2022.06.07.495179 Cold Spring Harbor Laboratory Press 2022-06-08 <![CDATA[ The Role of UBE2-Conjugating Enzymes in the Mechanism of MuRF1 Ubiquitylation ]]> https://biorxiv.org/content/10.1101/2022.06.13.495268v1?rss=1 Dawson, P. W. J. Baehr, L. M. Hughes, D. C. Knowles, T. J. Sridhar, P. Bodine, S. C. Lai, Y.-C. 2022-06-13 doi:10.1101/2022.06.13.495268 Cold Spring Harbor Laboratory Press 2022-06-13 <![CDATA[ Two types of motor inhibition after action errors in humans ]]> https://biorxiv.org/content/10.1101/2022.06.17.496641v1?rss=1 Guan, Y. Wessel, J. R. 2022-06-18 doi:10.1101/2022.06.17.496641 Cold Spring Harbor Laboratory Press 2022-06-18 <![CDATA[ Cochlear implant material effects on inflammatory cell function and foreign body response ]]> https://biorxiv.org/content/10.1101/2022.06.20.496419v1?rss=1 Jensen, M. J. Claussen, A. D. Higgins, T. Vielman-Quevado, R. Mostaert, B. Xu, L. Kirk, J. Hansen, M. R. 2022-06-22 doi:10.1101/2022.06.20.496419 Cold Spring Harbor Laboratory Press 2022-06-22 <![CDATA[ Non-random distribution of mitochondrial m.3243A>G heteroplasmy in human retina and its impact on cellular phenotype ]]> https://biorxiv.org/content/10.1101/2022.06.20.496449v1?rss=1 G allele was neither evenly nor randomly distributed across diverse cell types. All neuroectoderm- derived neural cells exhibited a high percentage of the mutant variant. However, a subset of mesoderm- derived lineage, namely the vasculature of the choroid, was near homoplasmic for the wildtype allele. Gene expression and chromatin accessibility profiles of cell types with high and low proportions of m.3243A>G implicate mTOR signaling in the cellular response to heteroplasmy. We further found by multimodal single-cell sequencing of retinal pigment epithelial cells that a high proportion of the pathogenic mtDNA variant was associated with transcriptionally and morphologically abnormal cells. Together, these findings show the non- random nature of mitochondrial variant partitioning in human mitochondrial disease and underscore its implications for mitochondrial disease pathogenesis and treatment. GRAPHICAL ABSTRACT O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=155 SRC="FIGDIR/small/496449v2_ufig1.gif" ALT="Figure 1"> View larger version (49K): org.highwire.dtl.DTLVardef@10b1c41org.highwire.dtl.DTLVardef@6c2d7corg.highwire.dtl.DTLVardef@1e4d09org.highwire.dtl.DTLVardef@153a5a0_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Mullin, N. K. Voigt, A. P. Flamme-Wiese, M. J. Liu, X. Riker, M. J. Varzavand, K. Stone, E. M. Tucker, B. A. Mullins, R. F. 2022-06-22 doi:10.1101/2022.06.20.496449 G heteroplasmy in human retina and its impact on cellular phenotype]]> Cold Spring Harbor Laboratory Press 2022-06-22 <![CDATA[ Bayesian Hierarchical Model for Immune Responses to Leishmania - a tick borne Co-Infection Study ]]> https://biorxiv.org/content/10.1101/2022.06.20.496877v1?rss=1 Pabon-Rodriguez, F. M. Brown, G. D. Scorza, B. M. Petersen, C. A. 2022-06-20 doi:10.1101/2022.06.20.496877 Cold Spring Harbor Laboratory Press 2022-06-20 <![CDATA[ The Chlamydia trachomatis type III secreted effector protein CteG induces centrosome amplification through interactions with centrin-2 ]]> https://biorxiv.org/content/10.1101/2022.06.23.496711v1?rss=1 Steiert, B. Icardi, C. Faris, R. Klingelhutz, A. J. Yau, P. Weber, M. M. 2022-06-23 doi:10.1101/2022.06.23.496711 Cold Spring Harbor Laboratory Press 2022-06-23 <![CDATA[ CaMKII binding to GluN2B flips a β-adrenergic switch from synaptic depression to potentiation ]]> https://biorxiv.org/content/10.1101/2022.06.23.497296v1?rss=1 Buonarati, O. R. Larsen, M. E. Qian, H. Hell, J. W. Bayer, K. U. 2022-06-24 doi:10.1101/2022.06.23.497296 Cold Spring Harbor Laboratory Press 2022-06-24 <![CDATA[ Durability of photografted zwitterionic hydrogel coatings for reduction of the foreign body response to cochlear implants ]]> https://biorxiv.org/content/10.1101/2022.06.24.497518v1?rss=1 Peel, A. Horne, R. Bennion, D. M. Guymon, C. A. Hansen, M. R. 2022-06-28 doi:10.1101/2022.06.24.497518 Cold Spring Harbor Laboratory Press 2022-06-28 <![CDATA[ TCF4 trinucleotide repeat expansions and UV irradiation are associated with ferroptosis susceptibility in Fuchs endothelial corneal dystrophy ]]> https://biorxiv.org/content/10.1101/2022.06.27.497862v1?rss=1 Saha, S. Skeie, J. M. Schmidt, G. A. Eggleston, T. Shevalye, H. Sales, C. S. Phruttiwanichakun, P. Field, M. Rinkoski, T. A. Fautsch, M. P. Baratz, K. H. Roy, M. Jun, A. S. Salem, A. K. Greiner, M. A. 2022-06-28 doi:10.1101/2022.06.27.497862 Cold Spring Harbor Laboratory Press 2022-06-28 <![CDATA[ Thalamocortical contribution to cognitive task activity ]]> https://biorxiv.org/content/10.1101/2022.06.28.497905v1?rss=1 Sorenson, E. Shine, J. M. Cole, M. W. Hwang, K. 2022-07-01 doi:10.1101/2022.06.28.497905 Cold Spring Harbor Laboratory Press 2022-07-01 <![CDATA[ Host-enemy interactions provide limited biotic resistance for a range-expanding species via reduced apparent competition ]]> https://biorxiv.org/content/10.1101/2022.06.28.498037v1?rss=1 Prior, K. M. Jones, D. G. Meadley-Dunphy, S. A. Lee, S. Milks, A. K. Daughton, S. Forbes, A. A. Powell, T. H. 2022-07-02 doi:10.1101/2022.06.28.498037 Cold Spring Harbor Laboratory Press 2022-07-02 <![CDATA[ Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming. ]]> https://biorxiv.org/content/10.1101/2022.06.29.497712v1?rss=1 Keine, C. Al-Yaari, M. Radulovic, T. Thomas, C. I. Ramos, P. V. Guerrero-Given, D. Kamasawa, N. Young, S. M. 2022-07-02 doi:10.1101/2022.06.29.497712 Cold Spring Harbor Laboratory Press 2022-07-02 <![CDATA[ Injury-related cell death and proteoglycan loss in articular cartilage: Numerical model combining necrosis, reactive oxygen species, and inflammatory cytokines ]]> https://biorxiv.org/content/10.1101/2022.06.29.498207v1?rss=1 Kosonen, J. Eskelinen, A. Orozco, G. Nieminen, P. Anderson, D. Grodzinsky, A. Korhonen, R. Tanska, P. 2022-07-02 doi:10.1101/2022.06.29.498207 Cold Spring Harbor Laboratory Press 2022-07-02 <![CDATA[ Avian and Human Influenza Viruses Exhibit Distinct Glycoconjugate Receptor Specificities in Human Lung Cells ]]> https://biorxiv.org/content/10.1101/2022.06.29.498208v1?rss=1 Liang, C.-Y. Huang, I. Han, J. Manivasagam, S. Plung, J. Sturtz, M. Yu, Y. Kandasamy, M. Gourronc, F. A. Klingelhutz, A. J. Choudhury, B. Rong, L. Perez, J. T. Neelamegham, S. Manicassamy, B. 2022-06-30 doi:10.1101/2022.06.29.498208 Cold Spring Harbor Laboratory Press 2022-06-30 <![CDATA[ Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition ]]> https://biorxiv.org/content/10.1101/2022.07.01.498399v1?rss=1 Li, Y. Balakrishnan, V. K. Rowse, M. Wu, C.-G. Bravos, A. P. Yadav, V. K. Ivarsson, Y. Strack, S. Novikova, I. V. Xing, Y. 2022-07-01 doi:10.1101/2022.07.01.498399 Cold Spring Harbor Laboratory Press 2022-07-01 <![CDATA[ α1 adrenergic receptor - PKC - Pyk2 - Src signaling boosts L-type Ca2+ channel Cav1.2 activity and long-term potentiation in rodents ]]> https://biorxiv.org/content/10.1101/2022.07.01.498400v1?rss=1 Man, K. N. M. Henderson, P. B. Kim, K. Shi, M. Zhang, M. Nieves-Cintron, M. Navedo, M. F. Horne, M. C. Hell, J. W. 2022-07-03 doi:10.1101/2022.07.01.498400 Cold Spring Harbor Laboratory Press 2022-07-03 <![CDATA[ Backbone amides are key determinants of Cl- selectivity in CLC ion channels ]]> https://biorxiv.org/content/10.1101/2022.07.01.498497v1?rss=1 Leisle, L. Lam, K. Dehghanighahnaviyeh, S. Fortea, E. Galpin, J. D. Ahern, C. A. Tajkhorshid, E. Accardi, A. 2022-07-03 doi:10.1101/2022.07.01.498497 Cold Spring Harbor Laboratory Press 2022-07-03 <![CDATA[ Comparative study of bacterial SPOR domains identifies functionally important differences in glycan binding affinity ]]> https://biorxiv.org/content/10.1101/2022.07.01.498525v1?rss=1 Yahashiri, A. Kaus, G. M. Popham, D. L. Houtman, J. C. D. Weiss, D. S. 2022-07-02 doi:10.1101/2022.07.01.498525 Cold Spring Harbor Laboratory Press 2022-07-02 <![CDATA[ Gamma-interferon-inducible lysosomal thiol reductase maintains cardiac immuno-metabolic homeostasis in heart failure ]]> https://biorxiv.org/content/10.1101/2022.07.03.498477v1?rss=1 Li, M. Wang, J. Qian, Q. Chen, B. Zhang, Z. Zhang, Y. Hall, D. D. Abel, E. D. Song, L.-S. Yang, L. 2022-07-04 doi:10.1101/2022.07.03.498477 Cold Spring Harbor Laboratory Press 2022-07-04 <![CDATA[ Obesity Disrupts Pituitary UPR Leading to NAFLD ]]> https://biorxiv.org/content/10.1101/2022.07.06.498610v1?rss=1 Qian, Q. Li, M. Zhang, Z. Davis, S. Rahmouni, K. Norris, A. W. Cao, H. Ding, W.-X. Yang, L. 2022-07-06 doi:10.1101/2022.07.06.498610 Cold Spring Harbor Laboratory Press 2022-07-06 <![CDATA[ Intense light unleashes male courtship behaviorin wild-type Drosophila ]]> https://biorxiv.org/content/10.1101/2022.07.12.499756v1?rss=1 Ueda, A. Berg, A. Khan, T. Li, S. Cramer, E. Ruzicka, M. Wu, C.-F. Iyengar, A. 2022-07-13 doi:10.1101/2022.07.12.499756 Cold Spring Harbor Laboratory Press 2022-07-13 <![CDATA[ Beta bursts over frontal cortex track the surprise of unexpected events in auditory, visual, and tactile modalities ]]> https://biorxiv.org/content/10.1101/2022.07.13.499837v1?rss=1 Tatz, J. R. Mather, A. Wessel, J. R. 2022-07-15 doi:10.1101/2022.07.13.499837 Cold Spring Harbor Laboratory Press 2022-07-15 <![CDATA[ In vivo functional genomics identifies essentiality of potassium homeostasis in medulloblastoma ]]> https://biorxiv.org/content/10.1101/2022.07.23.501234v1?rss=1 Fan, J. J. Wang, X. Erickson, A. W. Skowron, P. Wang, X. Chen, X. Shan, G. Bahrampour, S. Xiong, Y. Dong, W. Abeysundara, N. Francisco, M. A. Pusong, R. J. Suarez, R. A. Farooq, H. Holgado, B. L. Wu, X. Daniels, C. Dupuy, A. J. Cadinanos, J. Bradley, A. Bagchi, A. Moriarity, B. S. Largaespada, D. A. Morrissy, A. S. Ramaswamy, V. Mack, S. C. Garzia, L. Dirks, P. B. Wanggou, S. Li, X. Sun, Y. Taylor, M. D. Huang, X. 2022-07-23 doi:10.1101/2022.07.23.501234 Cold Spring Harbor Laboratory Press 2022-07-23 <![CDATA[ Pair housing does not alter incubation of craving, extinction, and reinstatement after heroin self-administration in female and male rats ]]> https://biorxiv.org/content/10.1101/2022.07.28.501777v1?rss=1 Nett, K. E. LaLumiere, R. T. 2022-08-01 doi:10.1101/2022.07.28.501777 Cold Spring Harbor Laboratory Press 2022-08-01 <![CDATA[ iPHoP: an integrated machine-learning framework to maximize host prediction for metagenome-assembled virus genomes ]]> https://biorxiv.org/content/10.1101/2022.07.28.501908v1?rss=1 Roux, S. Camargo, A. P. Coutinho, F. H. Dabdoub, S. M. Dutilh, B. E. Nayfach, S. Tritt, A. 2022-07-28 doi:10.1101/2022.07.28.501908 Cold Spring Harbor Laboratory Press 2022-07-28 <![CDATA[ Activity in developing prefrontal cortex is shaped by sleep and sensory experience ]]> https://biorxiv.org/content/10.1101/2022.07.31.502200v1?rss=1 Gomez, L. G. Dooley, J. C. Blumberg, M. S. 2022-08-03 doi:10.1101/2022.07.31.502200 Cold Spring Harbor Laboratory Press 2022-08-03 <![CDATA[ Epitranscriptomic N6-methyladenosine profile of SARS-CoV-2-infected human lung epithelial cells ]]> https://biorxiv.org/content/10.1101/2022.08.01.502311v1?rss=1 Phillips, S. Khadka, S. Bohan, D. Espada, C. E. Maury, W. Wu, L. 2022-08-01 doi:10.1101/2022.08.01.502311 Cold Spring Harbor Laboratory Press 2022-08-01 <![CDATA[ Selective Androgen Receptor Modulator Microparticle Formulation Reverses Muscle Hyperalgesia in Mouse Model of Widespread Muscle Pain ]]> https://biorxiv.org/content/10.1101/2022.08.02.502353v1?rss=1 Lesnak, J. B. Nakhla, D. S. Plumb, A. N. McMillan, A. Saha, S. Gupta, N. Xu, Y. Phruttiwanichakun, P. Rasmussen, L. Meyerholz, D. K. Salem, A. K. Sluka, K. A. 2022-08-04 doi:10.1101/2022.08.02.502353 Cold Spring Harbor Laboratory Press 2022-08-04 <![CDATA[ HD-PTP/PTPN23 hypomorphic mice display lipodystrophy ]]> https://biorxiv.org/content/10.1101/2022.08.02.502401v1?rss=1 Davies, B. A. Payne, J. A. Martin, C. P. Schultz, D. Childs, B. G. Zhang, C. Jeganathan, K. Sturmlechner, I. White, T. A. Bruin, A. d. Chen, H. Davies, M. A. Jachim, S. LeBrasseur, N. K. Piper, R. C. Li, H. Baker, D. J. van Deursen, J. Katzmann, D. J. 2022-08-03 doi:10.1101/2022.08.02.502401 Cold Spring Harbor Laboratory Press 2022-08-03 <![CDATA[ Single-molecule sequencing of animal mitochondrial genomes reveals chloroplast-like architecture and repeat-mediated recombination ]]> https://biorxiv.org/content/10.1101/2022.08.11.503648v1?rss=1 Sharbrough, J. Bankers, L. Cook, E. Fields, P. D. Jalinsky, J. McElroy, K. E. Neiman, M. Logsdon, J. M. Boore, J. L. 2022-08-14 doi:10.1101/2022.08.11.503648 Cold Spring Harbor Laboratory Press 2022-08-14 <![CDATA[ The RAM signaling pathway links morphology, thermotolerance, and CO2 tolerance in the global fungal pathogen Cryptococcus neoformans ]]> https://biorxiv.org/content/10.1101/2022.08.14.503895v1?rss=1 Chadwick, B. J. Pham, T. Xie, X. Ristow, L. C. Krysan, D. Lin, X. 2022-08-14 doi:10.1101/2022.08.14.503895 Cold Spring Harbor Laboratory Press 2022-08-14 <![CDATA[ Characterization of a novel estrogen- and progesterone-responsive endometrial cancer cell line: HCI-EC-23 ]]> https://biorxiv.org/content/10.1101/2022.08.25.505203v1?rss=1 Rush, C. M. Blanchard, Z. Polaski, J. T. Osborne, K. S. Osby, K. Vahrenkamp, J. M. Yang, C.-H. Lum, D. H. Hagan, C. R. Leslie, K. K. Pufall, M. A. Thiel, K. W. Gertz, J. 2022-08-25 doi:10.1101/2022.08.25.505203 Cold Spring Harbor Laboratory Press 2022-08-25 <![CDATA[ The calcineurin regulator Sarah enables acute and chronic forms of homeostatic plasticity at the Drosophila neuromuscular junction ]]> https://biorxiv.org/content/10.1101/2022.08.31.506100v1?rss=1 Armstrong, N. S. Frank, C. A. 2022-09-01 doi:10.1101/2022.08.31.506100 Cold Spring Harbor Laboratory Press 2022-09-01 <![CDATA[ Cardiovascular Hemodynamics in Mice with Tumor Necrosis Factor Receptor - Associated Factor 2 Mediated Cytoprotection in the Heart ]]> https://biorxiv.org/content/10.1101/2022.09.03.506447v1?rss=1 Marshall, A. G. Neikirk, K. Vue, Z. Beasley, H. K. Garza-Lopez, E. Vang, L. Barongan, T. Evans, Z. Anudokem, J. Pham, T. T. Gomez, J. A. Exil, V. Dai, D.-F. Entman, M. L. Taffet, G. E. Hinton, A. Reddy, A. K. 2022-09-06 doi:10.1101/2022.09.03.506447 Cold Spring Harbor Laboratory Press 2022-09-06 <![CDATA[ Bridging The Evolving Semantics: A Data Driven Approach to Knowledge Discovery In Biomedicine ]]> https://biorxiv.org/content/10.1101/2022.09.05.506661v1?rss=1 Jha, K. 2022-09-06 doi:10.1101/2022.09.05.506661 Cold Spring Harbor Laboratory Press 2022-09-06 <![CDATA[ Staphyloxanthin production by Staphylococcus aureus promotes resistance to oxidative stress to delay diabetic wound healing ]]> https://biorxiv.org/content/10.1101/2022.09.09.507290v1?rss=1 McCready-Vangi, A. R. Campbell, A. E. Uberoi, A. Lovins, V. M. White, E. K. Morgenstern, A. R. Gardner, S. E. Grice, E. A. 2022-09-09 doi:10.1101/2022.09.09.507290 Cold Spring Harbor Laboratory Press 2022-09-09 <![CDATA[ OPA1 Downregulation in Skeletal Muscle Induces MERC formation in an ATF4-Dependent Manner ]]> https://biorxiv.org/content/10.1101/2022.09.12.507669v1?rss=1 Hinton, A. Katti, P. Mungai, M. Hall, D. Koval, O. Shao, J. Vue, Z. Christensen, T. A. Lopez, E. G. Rostami, R. Neikirk, K. Lam, J. Alghanem, A. Ponce, J. Hicsasmaz, I. Streeter, J. Schickling, B. Bacevac, S. Grueter, C. Marshall, A. Beasley, H. K. DoKoo, Y. Bodine, S. Nava, N. G. R. Quintana, A. Trushina, E. Weatherford, E. Murray, S. A. Salisbury, J. Song, L.-S. Grumbach, I. Exil, V. Pereira, R. O. Glancy, B. Abel, E. D. 2022-09-15 doi:10.1101/2022.09.12.507669 Cold Spring Harbor Laboratory Press 2022-09-15 <![CDATA[ Neurofibromin 1 mediates sleep depth in Drosophila ]]> https://biorxiv.org/content/10.1101/2022.09.15.508161v1?rss=1 Brown, E. B. Zhang, J. Lloyd, E. Lanzon, E. Botero, V. Tomchik, S. Keene, A. C. 2022-09-19 doi:10.1101/2022.09.15.508161 Cold Spring Harbor Laboratory Press 2022-09-19 <![CDATA[ Temporal dynamics of the multi-omic response to endurance exercise training across tissues ]]> https://biorxiv.org/content/10.1101/2022.09.21.508770v1?rss=1 MoTrPAC Study Group, Amar, D. Gay, N. R. Jean Beltran, P. M. Adkins, J. N. Almagro Armenteros, J. J. Ashley, E. Avila-Pacheco, J. Bae, D. Bararpour, N. Burant, C. Clish, C. Cutter, G. Dasari, S. Dennis, C. Evans, C. R. Fernandez, F. M. Gaul, D. Ge, Y. Gerszten, R. Goodyear, L. J. Hou, Z. Ilkayeva, O. Ivanova, A. A. Jimenez-Morales, D. Kachman, M. T. Keshishian, H. Kraus, W. E. Lanza, I. R. Li, J. Lindholm, M. E. Lira, A. C. Many, G. M. Marwaha, S. Miller, M. E. Muehlbauer, M. J. Nair, K. S. Nair, V. D. Natarajan Raja, A. Newgard, C. Ortlund, E. A. Pie 2022-09-23 doi:10.1101/2022.09.21.508770 Cold Spring Harbor Laboratory Press 2022-09-23 <![CDATA[ Biochemical identification of a nuclear coactivator protein required for AtrR-dependent gene regulation in Aspergillus fumigatus ]]> https://biorxiv.org/content/10.1101/2022.09.26.509624v1?rss=1 Paul, S. Ror, S. McDonald, W. H. Moye-Rowley, W. S. 2022-09-28 doi:10.1101/2022.09.26.509624 Cold Spring Harbor Laboratory Press 2022-09-28 <![CDATA[ Cardiac MAO-A inhibition protects against catecholamine-induced ventricular arrhythmias via enhanced diastolic calcium control ]]> https://biorxiv.org/content/10.1101/2022.09.29.510139v1?rss=1 Shi, Q. Malik, H. Streeter, J. Wang, J. Huo, R. Crawford, R. M. Shih, J. C. Chen, B. Hall, D. Abel, E. D. Song, L.-S. Anderson, E. J. 2022-10-02 doi:10.1101/2022.09.29.510139 Cold Spring Harbor Laboratory Press 2022-10-02 <![CDATA[ Dynein-mediated trafficking and degradation of nephrin in diabetic podocytopathy ]]> https://biorxiv.org/content/10.1101/2022.10.01.510475v1?rss=1 Sun, H. Weidner, J. Allamargot, C. Piper, R. C. Misurac, J. Nester, C. 2022-10-04 doi:10.1101/2022.10.01.510475 Cold Spring Harbor Laboratory Press 2022-10-04 <![CDATA[ Epigenetics of post-operative delirium: A genome-wide DNA methylation study of neurosurgery patients ]]> https://biorxiv.org/content/10.1101/2022.10.04.510706v1?rss=1 Yamanashi, T. Crutchley, K. J. Wahba, N. E. Nagao, T. Marra, P. S. Akers, C. C. Sullivan, E. J. Iwata, M. Howard, M. A. Cho, H. R. Kawasaki, H. Hughes, C. G. Pandharipande, P. P. Hefti, M. M. Shinozaki, G. 2022-10-07 doi:10.1101/2022.10.04.510706 Cold Spring Harbor Laboratory Press 2022-10-07 <![CDATA[ UV irradiation remodels the specificity landscape of transcription factors ]]> https://biorxiv.org/content/10.1101/2022.10.07.511343v1?rss=1 Mielko, Z. Zhang, Y. Liu, Y. Schaich, M. A. Schnable, B. Burdinski, D. Adar, S. Pufall, M. Van Houten, B. Gordan, R. Afek, A. 2022-10-08 doi:10.1101/2022.10.07.511343 Cold Spring Harbor Laboratory Press 2022-10-08 <![CDATA[ Pseudomonas aeruginosa can diversify after host cell invasion to establish multiple intracellular niches ]]> https://biorxiv.org/content/10.1101/2022.10.07.511388v1?rss=1 Kumar, N. G. Nieto, V. Kroken, A. R. Jedel, E. Grosser, M. R. Hallsten, M. E. Metruccio, M. M. E. Yahr, T. L. Evans, D. J. Fleiszig, S. M. J. 2022-10-08 doi:10.1101/2022.10.07.511388 Cold Spring Harbor Laboratory Press 2022-10-08 <![CDATA[ Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup ]]> https://biorxiv.org/content/10.1101/2022.10.13.512111v1?rss=1 Huggins, A. A. Baird, C. L. Briggs, M. Laskowitz, S. Fouda, S. Haswell, C. C. Sun, D. Salminen, L. E. Jahanshad, N. Thomopoulos, S. I. Veltman, D. J. Frijling, J. L. Olff, M. van Zuiden, M. Koch, S. B. J. Nawijn, L. Wang, L. Zhu, Y. Li, G. Stein, D. J. Ipser, J. Seedat, S. du Plessis, S. van den Heuvel, L. L. Suarez-Jimenez, B. Zhu, X. Kim, Y. He, X. Zilcha-Mano, S. Lazarov, A. Neria, Y. Stevens, J. S. Ressler, K. J. Jovanovic, T. van Rooij, S. J. H. Fani, N. Hudson, A. R. Mueller, S. C. Sierk, A. Manthey, A. Walter, H. Daniels, J. K. Schmahl, C. Herz 2022-10-17 doi:10.1101/2022.10.13.512111 Cold Spring Harbor Laboratory Press 2022-10-17 <![CDATA[ Characterization of the Tau Interactome in Human Brain Reveals Isoform-Dependent Interaction with 14-3-3 Family Proteins ]]> https://biorxiv.org/content/10.1101/2022.10.17.512532v1?rss=1 Betters, R. K. Luhmann, E. Gottschalk, A. C. Xu, Z. Ptak, C. Fiock, K. L. Radoshevich, L. Hefti, M. M. 2022-10-18 doi:10.1101/2022.10.17.512532 Cold Spring Harbor Laboratory Press 2022-10-18 <![CDATA[ Infralimbic projections to the nucleus accumbens shell and amygdala regulate the encoding of cocaine extinction learning ]]> https://biorxiv.org/content/10.1101/2022.10.20.513048v1?rss=1 Nett, K. E. Zimbelman, A. R. McGregor, M. S. Alizo Vera, V. Harris, M. R. LaLumiere, R. T. 2022-10-21 doi:10.1101/2022.10.20.513048 Cold Spring Harbor Laboratory Press 2022-10-21 <![CDATA[ Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity ]]> https://biorxiv.org/content/10.1101/2022.10.22.513357v1?rss=1 Marra, P. S. Yamanashi, T. Crutchley, K. J. Wahba, N. E. Anderson, Z.-E. M. Modukuri, M. Chang, G. Tran, T. Iwata, M. Cho, H. R. Shinozaki, G. 2022-10-24 doi:10.1101/2022.10.22.513357 Cold Spring Harbor Laboratory Press 2022-10-24 <![CDATA[ Junctophilin-2 promotes cardiomyocyte survival by blocking MURF1-mediated Junctin ubiquitination and proteasome-dependent degradation ]]> https://biorxiv.org/content/10.1101/2022.10.23.513420v1?rss=1 Ji, X. Huang, Y. Ni, R. Zheng, D. Fan, G.-C. Jones, D. Song, L.-S. Chakrabarti, S. Su, Z. Peng, T. 2022-10-24 doi:10.1101/2022.10.23.513420 Cold Spring Harbor Laboratory Press 2022-10-24 <![CDATA[ Antagonistic roles of canonical and alternative RPA in tandem CAG repeat diseases ]]> https://biorxiv.org/content/10.1101/2022.10.24.513561v1?rss=1 15 neurodegenerative diseases, where ongoing expansions in patients brains are thought to drive disease onset and progression. Repeat length mutations will involve single-stranded DNAs prone to form mutagenic DNA structures. However, the involvement of single-stranded DNA binding proteins (SSBs) in the prevention or formation of repeat instability is poorly understood. Here, we assessed the role of two SSBs, canonical RPA (RPA1-RPA2-RPA3) and the related Alternative-RPA (Alt-RPA, RPA1-RPA4-RPA3), where the primate-specific RPA4 replaces RPA2. RPA is essential for all forms of DNA metabolism, while Alt-RPA has undefined functions. RPA and Alt-RPA are upregulated 2- and 10-fold, respectively, in brains of Huntington disease (HD) and spinocerebellar ataxia type 1 (SCA1) patients. Correct repair of slipped-CAG DNA structures, intermediates of expansion mutations, is enhanced by RPA, but blocked by Alt-RPA. Slipped-DNAs are bound and melted more efficiently by RPA than by Alt-RPA. Removal of excess slipped-DNAs by FAN1 nuclease is enhanced by RPA, but blocked by Alt-RPA. Protein-protein interactomes (BioID) reveal unique and shared partners of RPA and Alt-RPA, including proteins involved in CAG instability and known modifiers of HD and SCA1 disease. RPA overexpression inhibits rampant CAG expansions in SCA1 mouse brains, coinciding with improved neuron morphology and rescued motor phenotypes. Thus, SSBs are involved in repeat length mutations, where Alt-RPA antagonistically blocks RPA from suppressing CAG expansions and hence pathogenesis. The processing of repeat length mutations is one example by which an Alt-RPA{leftrightarrow}RPA antagonistic interaction can affect outcomes, illuminating questions as to which of the many processes mediated by canonical RPA may also be modulated by Alt-RPA. ]]> Gall-Duncan, T. Luo, J. Jurkovic, C.-M. Fischer, L. Fujita, K. Leib, D. Li, V. Harding, R. J. Tran, S. Chen, R. Tanaka, H. Deshmukh, A. L. Mason, A. G. Levesque, D. Khan, M. Lanni, S. Sato, N. Caron, M.-C. Masson, J.-Y. Panigrahi, G. B. Prasolava, T. Wang, P. Lau, R. Tippett, L. Turner, C. La Spada, A. R. Campos, E. I. Curtis, M. A. Boisvert, F.-M. Faull, R. L. Davidson, B. L. Okazawa, H. Wold, M. S. Pearson, C. E. 2022-10-26 doi:10.1101/2022.10.24.513561 Cold Spring Harbor Laboratory Press 2022-10-26 <![CDATA[ Sex-biasing influence of autism-associated Ube3a gene overdosage at connectomic, behavioral and transcriptomic levels ]]> https://biorxiv.org/content/10.1101/2022.10.25.513747v1?rss=1 Montani, C. Pagani, M. De Guzman, E. Balasco, L. Alvino, F. De Felice, A. Galbusera, A. Nickl-Jockstat, T. Lau, P. Borsotti, N. Pasqualetti, M. Mattioni, L. Provenzano, G. Bozzi, Y. Lombardo, M. Gozzi, A. 2022-10-25 doi:10.1101/2022.10.25.513747 Cold Spring Harbor Laboratory Press 2022-10-25 <![CDATA[ ISG15 is required for the dissemination of Vaccinia virus extracellular virions ]]> https://biorxiv.org/content/10.1101/2022.10.27.514002v1?rss=1 Becares, M. Albert, M. Tarrega, C. Coloma, R. Falqui, M. Luhmann, E. Radoshevich, L. Guerra, S. 2022-10-28 doi:10.1101/2022.10.27.514002 Cold Spring Harbor Laboratory Press 2022-10-28 <![CDATA[ Alveolar epithelial type 1 cells serve as a cell of origin for lung adenocarcinoma with distinct molecular and phenotypic presentation ]]> https://biorxiv.org/content/10.1101/2022.10.29.514334v1?rss=1 Yang, M. Shen, H. Flodby, P. Koss, M. Bassiouni, R. Liu, Y. Jashashvilli, T. Stueve, T. R. Mullen, D. J. Ryan, A. L. Carpten, J. Castaldi, A. Wallace, W. D. Zhou, B. Borok, MD, Z. Marconett, C. N. 2022-10-31 doi:10.1101/2022.10.29.514334 Cold Spring Harbor Laboratory Press 2022-10-31 <![CDATA[ Antigen presentation by discrete class I molecules on brain endothelium dynamically regulates T-cell mediated neuropathology in experimental cerebral malaria ]]> https://biorxiv.org/content/10.1101/2022.10.30.514412v1?rss=1 Fain, C. E. Zheng, J. Jin, F. Ayasoufi, K. Wu, Y. Lilley, M. T. Dropik, A. R. Wolf, D. M. Rodriguez, R. C. Aibaidula, A. Tritz, Z. P. Bouchal, S. M. Pewe, L. L. Urban, S. L. Chen, Y. Chang, S.-Y. Hansen, M. J. Kachergus, J. M. Shi, J. Thompson, A. A. Harty, J. T. Parney, I. F. Sun, J. Wu, L.-J. Johnson, A. J. 2022-11-01 doi:10.1101/2022.10.30.514412 Cold Spring Harbor Laboratory Press 2022-11-01 <![CDATA[ Synchronized proinsulin trafficking reveals delayed Golgi export accompanies beta-cell secretory dysfunction in a rodent model of hyperglycemia ]]> https://biorxiv.org/content/10.1101/2022.10.31.514578v1?rss=1 Boyer, C. K. Zhang, J. Wang, Y. Stephens, S. B. 2022-11-01 doi:10.1101/2022.10.31.514578 Cold Spring Harbor Laboratory Press 2022-11-01 <![CDATA[ Phosphatidylethanolamine facilitates mitochondrial pyruvate entry to regulate metabolic flexibility ]]> https://biorxiv.org/content/10.1101/2022.11.01.514767v1?rss=1 Siripoksup, P. Cao, G. Cluntun, A. A. A. Maschek, J. A. Pearce, Q. Lang, M. J. Eshima, H. Opurum, P. C. Mahmassani, Z. S. Taylor, E. B. Cox, J. E. Drummond, M. J. Rutter, J. Funai, K. 2022-11-02 doi:10.1101/2022.11.01.514767 Cold Spring Harbor Laboratory Press 2022-11-02 <![CDATA[ Investigations into hydrogen sulfide-induced suppression of neuronal activity in vivo and calcium dysregulation in vitro ]]> https://biorxiv.org/content/10.1101/2022.11.14.516514v1?rss=1 5 ppm dysregulated SCO patterns in a dose-dependent manner. Inhibitors of NMDA and AMPA receptors magnified H2S-induced SCO suppression. Inhibitors of L-type voltage gated Ca2+ channels (VGCC) and transient receptor potential (TRP) channels prevented H2S-induced SCO suppression. Inhibitors of T-type VGCC, ryanodine receptors, and sodium channels had no measurable influence on H2S-induced SCO suppression. Exposures to >5 ppm sulfide also suppressed neuronal electrical activity in PCN measured by multi-electrode array (MEA), an effect alleviated by pretreatment with the nonselective TRP inhibitor 2-APB. The TRP inhibitor also reduced PCN cell death from sulfide exposure. These results improve our understanding of the role of different Ca2+ channels in acute H2S-induced neurotoxicity and identify TRP channel modulators as novel structures with potential therapeutic benefits. ]]> Kim, D.-S. Pessah, I. N. Santana, C. M. Purnell, B. Li, R. Buchanan, G. F. Rumbeiha, W. K. 2022-11-16 doi:10.1101/2022.11.14.516514 Cold Spring Harbor Laboratory Press 2022-11-16 <![CDATA[ Consciousness is indexed by analogous cortical reorganization during sleep and anesthesia ]]> https://biorxiv.org/content/10.1101/2022.11.15.516653v1?rss=1 Krause, B. M. Campbell, D. I. Kovach, C. K. Mueller, R. N. Kawasaki, H. Nourski, K. V. Banks, M. I. 2022-11-17 doi:10.1101/2022.11.15.516653 Cold Spring Harbor Laboratory Press 2022-11-17 <![CDATA[ Toxicity impacts on human adipose MSCs acutely exposed to Aroclor and non-Aroclor mixtures of PCBs. ]]> https://biorxiv.org/content/10.1101/2022.11.17.516943v1?rss=1 20 M, the majority of MSCs die, while at 1-10 M MSCs remained viable but display numerous alterations to their phenotype. At these sublethal concentrations, MSC rate of expansion slowed, and morphology changed. Further assessment revealed PCB-exposed MSCs had impaired adipogenesis and a modest decrease in immunosuppressive capabilities. Thus, exposure to PCB mixtures found in schools negatively impacts the health and function of adipose MSCs. This work has implications for human health due to MSCs role in supporting the growth and maintenance of adipose tissue. SYNOPSISPCB mixtures found in schools are toxic to human adipose mesenchymal stem/stromal cells, stunting their growth and altering their function in ways that could contribute to metabolic diseases. ]]> Behan-Bush, R. M. Liszewski, J. N. Schrodt, M. V. Vats, B. Li, X. Lehmler, H.-J. Klingelhutz, A. J. Ankrum, J. A. 2022-11-17 doi:10.1101/2022.11.17.516943 Cold Spring Harbor Laboratory Press 2022-11-17 <![CDATA[ Measuring the non-selective effects of motor inhibition using isometric force recordings ]]> https://biorxiv.org/content/10.1101/2022.11.17.516968v1?rss=1 Rangel, B. O. Novembre, G. Wessel, J. R. 2022-11-18 doi:10.1101/2022.11.17.516968 Cold Spring Harbor Laboratory Press 2022-11-18 <![CDATA[ Improved high-dimensional multivariate autoregressive model estimation of human electrophysiological data using fMRI priors ]]> https://biorxiv.org/content/10.1101/2022.11.18.516669v1?rss=1 Nagle, A. Gerrelts, J. P. Krause, B. Boes, A. D. Bruss, J. E. Nourski, K. V. Banks, M. I. Van Veen, B. 2022-11-20 doi:10.1101/2022.11.18.516669 Cold Spring Harbor Laboratory Press 2022-11-20 <![CDATA[ Tau pathology in the dorsal raphe may be a prodromal indicator of Alzheimer's disease ]]> https://biorxiv.org/content/10.1101/2022.11.22.517403v1?rss=1 Pierson, S. Fiock, K. Wang, R. Balasubramanian, N. Khan, K. Betters, R. Lee, G. Hefti, M. M. Marcinkiewcz, C. A. 2022-11-23 doi:10.1101/2022.11.22.517403 Cold Spring Harbor Laboratory Press 2022-11-23 <![CDATA[ Neuronal IL-17 controls C. elegans developmental diapause through p53/CEP-1 ]]> https://biorxiv.org/content/10.1101/2022.11.22.517560v1?rss=1 Godthi, A. Srijit, D. Cruz-Corchado, J. Deonarine, A. Misel-Wuchter, K. Issuree, P. D. Prahlad, V. 2022-11-24 doi:10.1101/2022.11.22.517560 Cold Spring Harbor Laboratory Press 2022-11-24 <![CDATA[ Transcriptional programs controlling lineages specification of mandibular epithelium during tooth initiation ]]> https://biorxiv.org/content/10.1101/2022.11.26.518052v1?rss=1 Shao, F. Phan, A.-V. Van Otterloo, E. Cao, H. 2022-11-26 doi:10.1101/2022.11.26.518052 Cold Spring Harbor Laboratory Press 2022-11-26 <![CDATA[ Intravital imaging-based genetic screen reveals the transcriptional network governing Candida albicans filamentation during mammalian infection ]]> https://biorxiv.org/content/10.1101/2022.11.27.518093v1?rss=1 Wakade, R. S. Ristow, L. C. Wellington, M. Krysan, D. J. 2022-11-28 doi:10.1101/2022.11.27.518093 Cold Spring Harbor Laboratory Press 2022-11-28 <![CDATA[ Reducing the foreign body response on human cochlear implants and their materials in vivo with photografted zwitterionic hydrogel coatings ]]> https://biorxiv.org/content/10.1101/2022.11.28.518125v1?rss=1 View larger version (27K): org.highwire.dtl.DTLVardef@1d92121org.highwire.dtl.DTLVardef@e2ca3org.highwire.dtl.DTLVardef@948783org.highwire.dtl.DTLVardef@14ce647_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Horne, R. R. Ben-Shlomo, N. Jensen, M. Ellerman, M. Escudero, C. Hua, R. Z. Bennion, D. Guymon, C. A. Hansen, M. R. 2022-11-29 doi:10.1101/2022.11.28.518125 Cold Spring Harbor Laboratory Press 2022-11-29 <![CDATA[ Twitching cells use a chemoreceptor to detect bacterial competitors ]]> https://biorxiv.org/content/10.1101/2022.11.28.518211v1?rss=1 Yarrington, K. D. Shendruk, T. N. Limoli, D. H. 2022-11-28 doi:10.1101/2022.11.28.518211 Cold Spring Harbor Laboratory Press 2022-11-28 <![CDATA[ Proteomic profiling identifies biomarkers of COVID-19 severity ]]> https://biorxiv.org/content/10.1101/2022.11.29.518411v1?rss=1 Harriott, N. C. Ryan, A. L. 2022-11-30 doi:10.1101/2022.11.29.518411 Cold Spring Harbor Laboratory Press 2022-11-30 <![CDATA[ H3.1Cys96 oxidation by mitochondrial ROS promotes chromatin remodeling, breast cancer progression to metastasis and multi-drug resistance ]]> https://biorxiv.org/content/10.1101/2022.12.01.517361v1?rss=1 Palma, F. R. Ogata, F. T. Coelho, D. R. Pulakanti, K. Meyer, A. Huang, Y. Daves, J. M. Schipma, M. J. Furdui, C. M. Spitz, D. R. Gantner, B. N. Rao, S. Backman, V. Bonini, M. G. 2022-12-02 doi:10.1101/2022.12.01.517361 Cold Spring Harbor Laboratory Press 2022-12-02 <![CDATA[ Joint Multi-Ancestry and Admixed GWAS Reveals the Complex Genetics behind Human Cranial Vault Shape ]]> https://biorxiv.org/content/10.1101/2022.12.01.518684v1?rss=1 Goovaerts, S. Hoskens, H. Eller, R. J. Herrick, N. Musolf, A. M. Justice, C. M. Yuan, M. Naqvi, S. Lee, M. K. Vandermeulen, D. Szabo-Rogers, H. L. Romitti, P. A. Boyadjiev, S. A. Marazita, M. L. Shaffer, J. R. Shriver, M. D. Wysocka, J. Walsh, S. Weinberg, S. M. Claes, P. 2022-12-02 doi:10.1101/2022.12.01.518684 Cold Spring Harbor Laboratory Press 2022-12-02 <![CDATA[ HexSDF are Required for Synthesis of a Novel Glycolipid that Mediates Daptomycin and Bacitracin Resistance in C. difficile ]]> https://biorxiv.org/content/10.1101/2022.12.06.519413v1?rss=1 Pannullo, A. G. Goldfine, H. Guan, Z. Ellermeier, C. D. 2022-12-07 doi:10.1101/2022.12.06.519413 Cold Spring Harbor Laboratory Press 2022-12-07 <![CDATA[ The impact of sex and physical activity on the local immune response to muscle pain ]]> https://biorxiv.org/content/10.1101/2022.12.07.519473v1?rss=1 Lesnak, J. B. Hayashi, K. Plumb, A. N. Janowski, A. J. Chimenti, M. S. Sluka, K. A. 2022-12-10 doi:10.1101/2022.12.07.519473 Cold Spring Harbor Laboratory Press 2022-12-10 <![CDATA[ Mathematical modeling of ion homeostasis & cell volume stabilization: impact of ion transporters, impermeant molecules, & Donnan effect ]]> https://biorxiv.org/content/10.1101/2022.12.08.519683v1?rss=1 Aminzare, Z. Kay, A. R. 2022-12-12 doi:10.1101/2022.12.08.519683 Cold Spring Harbor Laboratory Press 2022-12-12 <![CDATA[ Multimodal Imaging-Based Classification of PTSD Using Data-Driven Computational Approaches: A Multisite Big Data Study from the ENIGMA-PGC PTSD Consortium ]]> https://biorxiv.org/content/10.1101/2022.12.12.519838v1?rss=1 Zhu, X. Kim, Y. Ravid, O. He, X. Suarez-Jimenez, B. Zilcha-Mano, S. Lazarov, A. Lee, S. Abdallah, C. G. Angstadt, M. Averill, C. L. Baird, C. L. Baugh, L. A. Blackford, J. U. Bomyea, J. Bruce, S. E. Bryant, R. A. Cao, Z. Choi, K. Cisler, J. Cotton, A. S. Daniels, J. K. Davenport, N. D. Davidson, R. J. DeBellis, M. D. Dennis, E. L. Densmore, M. deRoon-Cassini, T. Disner, S. G. El Hage, W. Etkin, A. Fani, N. Fercho, K. A. Fitzgerald, J. Forster, G. L. Frijling, J. L. Geuze, E. Gonenc, A. Gordon, E. M. Gruber, S. Grupe, D. W. Guenette, J. P. Haswell, C. C 2022-12-13 doi:10.1101/2022.12.12.519838 Cold Spring Harbor Laboratory Press 2022-12-13 <![CDATA[ Tobacco smoke exposure results in recruitment of inflammatory airspace monocytes and accelerated growth of Mycobacterium tuberculosis ]]> https://biorxiv.org/content/10.1101/2022.12.21.521304v1?rss=1 Corleis, B. Tzouanas, C. N. Wadsworth, M. H. Cho, J. L. Linder, A. H. Schiff, A. E. Dickey, A. K. Medoff, B. D. Shalek, A. K. Kwon, D. S. 2022-12-21 doi:10.1101/2022.12.21.521304 Cold Spring Harbor Laboratory Press 2022-12-21 <![CDATA[ Native Adiponectin Plays a Role in the Adipocyte Mediated Conversion of Fibroblasts to Myofibroblasts ]]> https://biorxiv.org/content/10.1101/2022.12.23.521683v1?rss=1 El-Hattab, M. Y. Sinclair, N. Liszewski, J. N. Schhrodt, M. V. Herrmann, J. Klingelhutz, A. J. Sander, E. A. Ankrum, J. A. 2022-12-23 doi:10.1101/2022.12.23.521683 Cold Spring Harbor Laboratory Press 2022-12-23 <![CDATA[ GDF15 Is Required for Cold-Induced Thermogenesis and Contributes to Improve Systemic Metabolic Health Following Loss of OPA1 in Brown Adipocytes ]]> https://biorxiv.org/content/10.1101/2022.12.23.521796v1?rss=1 Jena, J. Pena, L. M. G. Weatherford, E. T. Marti, A. Bjorkman, S. H. Kato, K. Koneru, J. Chen, J. H. Seeley, R. Abel, E. D. Pereira, R. O. 2022-12-23 doi:10.1101/2022.12.23.521796 Cold Spring Harbor Laboratory Press 2022-12-23 <![CDATA[ Membrane association is required for Stmn2-mediated axon protection ]]> https://biorxiv.org/content/10.1101/2022.12.23.521801v1?rss=1 Thornburg-Suresh, E. J. C. Richardson, J. E. Summers, D. W. 2022-12-23 doi:10.1101/2022.12.23.521801 Cold Spring Harbor Laboratory Press 2022-12-23 <![CDATA[ Epigenetic reprogramming shapes the cellular landscape of schwannoma ]]> https://biorxiv.org/content/10.1101/2022.12.23.521842v1?rss=1 Liu, S. J. Casey-Clyde, T. Cho, N. W. Swinderman, J. Pekmezci, M. Dougherty, M. C. Foster, K. Chen, W. C. Villanueva-Meyer, J. E. Swaney, D. L. Vasudevan, H. N. Choudhury, A. Breshears, J. D. Lang, U. E. Eaton, C. D. Hiam-Galvez, K. J. Stevenson, E. Chen, K.-H. Lien, B. V. Wu, D. Braunstein, S. E. Sneed, P. K. Magill, S. T. Lim, D. A. McDermott, M. W. Berger, M. S. Perry, A. Krogan, N. J. Hansen, M. Spitzer, M. H. Gilbert, L. A. Theodosopoulos, P. V. Raleigh, D. R. 2022-12-24 doi:10.1101/2022.12.23.521842 Cold Spring Harbor Laboratory Press 2022-12-24 <![CDATA[ SUMOylation of the Cardiac Sodium Channel NaV1.5 Modifies Inward Current and Cardiac Excitability ]]> https://biorxiv.org/content/10.1101/2022.12.26.521675v1?rss=1 Yoon, J.-Y. Greiner, A. Jacobs, J. S. Kim, Y.-R. Rasmussen, T. P. Kutschke, W. Matasic, D. S. Vikram, A. Gaddam, R. R. Mehdi, H. Irani, K. London, B. 2022-12-26 doi:10.1101/2022.12.26.521675 Cold Spring Harbor Laboratory Press 2022-12-26 <![CDATA[ ISG15-modification of the Arp2/3 complex restricts pathogen spread ]]> https://biorxiv.org/content/10.1101/2022.12.27.522022v1?rss=1 Zhang, Y. Ripley, B. M. Ouyang, W. Sturtz, M. Upton, E. Luhmann, E. Vessely, M. Coloma, R. Schwery, N. Anthony, S. M. Goeken, A. Moninger, T. O. Harty, J. T. Klingelhutz, A. J. Lundberg, E. Meyerholz, D. K. Manicassamy, B. Stipp, C. S. Guerra, S. Radoshevich, L. 2022-12-27 doi:10.1101/2022.12.27.522022 Cold Spring Harbor Laboratory Press 2022-12-27 <![CDATA[ The Role of Polyglutamine in Inter- and Intra-molecular Interactions in Med15-dependent Regulation ]]> https://biorxiv.org/content/10.1101/2022.12.29.522246v1?rss=1 Cooper, D. G. Fassler, J. S. 2022-12-29 doi:10.1101/2022.12.29.522246 Cold Spring Harbor Laboratory Press 2022-12-29 <![CDATA[ Predicting alcohol-related memory problems in older adults: A machine learning study with multi-domain features ]]> https://biorxiv.org/content/10.1101/2022.12.30.522330v1?rss=1 Kamarajan, C. Pandey, A. K. Chorlian, D. B. Meyers, J. L. Kinreich, S. Pandey, G. Subbie Saenz de Viteri, S. Zhang, J. Kuang, W. Barr, P. B. Aliev, F. Anokhin, A. P. Plawecki, M. H. Kuperman, S. Almasy, L. Merikangas, A. Brislin, S. J. Bauer, L. Hesselbrock, V. Chan, G. Kramer, J. Lai, D. Hartz, S. Bierut, L. J. McCutcheon, V. V. Bucholz, K. K. Dick, D. M. Schuckit, M. A. Edenberg, H. J. Porjesz, B. 2023-01-02 doi:10.1101/2022.12.30.522330 Cold Spring Harbor Laboratory Press 2023-01-02 <![CDATA[ The Physical Basis of Osmosis ]]> https://biorxiv.org/content/10.1101/2023.01.02.522450v1?rss=1 Manning, G. S. Kay, A. R. 2023-01-04 doi:10.1101/2023.01.02.522450 Cold Spring Harbor Laboratory Press 2023-01-04 <![CDATA[ Liver Fibroblast Growth Factor 21 (FGF21) is Required for the Full Anorectic Effect of the Glucagon-Like Peptide-1 Receptor Agonist Liraglutide in Male Mice fed High Carbohydrate Diets ]]> https://biorxiv.org/content/10.1101/2023.01.03.522509v1?rss=1 Le, T. D. V. Fathi, P. Watters, A. B. Ellis, B. J. Bozadjieva-Kramer, N. Perez, M. B. Sullivan, A. I. Rose, J. P. Baggio, L. L. Koehler, J. Brown, J. L. Bales, M. B. Nwaba, K. G. Campbell, J. E. Drucker, D. J. Potthoff, M. J. Seeley, R. J. Ayala, J. E. 2023-01-04 doi:10.1101/2023.01.03.522509 Cold Spring Harbor Laboratory Press 2023-01-04 <![CDATA[ Maternal diesel exposure and maternal choline supplementation interactions in fetal and placental immune factors ]]> https://biorxiv.org/content/10.1101/2023.01.04.522511v1?rss=1 Maurer, S. V. Bolton, J. L. Bilbo, S. D. Williams, C. L. 2023-01-05 doi:10.1101/2023.01.04.522511 Cold Spring Harbor Laboratory Press 2023-01-05 <![CDATA[ Multiomic identification of key transcriptional regulatory programs during endurance exercise training ]]> https://biorxiv.org/content/10.1101/2023.01.10.523450v1?rss=1 Smith, G. R. Zhao, B. Lindholm, M. E. Raja, A. Viggars, M. R. Pincas, H. Gay, N. R. Sun, Y. Ge, Y. Nair, V. D. Sanford, J. A. Amper, M. A. S. Vasoya, M. Smith, K. S. Montgomery, S. B. Zaslavsky, E. Bodine, S. C. Esser, K. A. Walsh, M. J. Snyder, M. Sealfon, S. C. 2023-01-12 doi:10.1101/2023.01.10.523450 Cold Spring Harbor Laboratory Press 2023-01-12 <![CDATA[ Candida albicans oropharyngeal infection is an exception to iron-based nutritional immunity ]]> https://biorxiv.org/content/10.1101/2023.01.11.523704v1?rss=1 Solis, N. V. Wakade, R. S. Filler, S. Krysan, D. J. 2023-01-12 doi:10.1101/2023.01.11.523704 Cold Spring Harbor Laboratory Press 2023-01-12 <![CDATA[ The mitochondrial multi-omic response to exercise training across tissues ]]> https://biorxiv.org/content/10.1101/2023.01.13.523698v1?rss=1 Amar, D. Gay, N. R. Jimenez-Morales, D. Jean Beltran, P. M. Ramaker, M. E. Natarajan Raja, A. Zhao, B. Sun, Y. Marwaha, S. Gaul, D. Hershman, S. G. Xia, A. Lanza, I. Fernandez, F. M. Montgomery, S. B. Hevener, A. L. Ashley, E. Walsh, M. J. Sparks, L. M. Burant, C. F. Rector, R. S. Thyfault, J. Wheeler, M. T. Goodpaster, B. H. Coen, P. M. Schenk, S. Bodine, S. C. Lindholm, M. E. MoTrPAC Study Group, 2023-01-13 doi:10.1101/2023.01.13.523698 Cold Spring Harbor Laboratory Press 2023-01-13 <![CDATA[ Active Gαi/o mutants accelerate breast tumor metastasis via the c-Src pathway ]]> https://biorxiv.org/content/10.1101/2023.01.16.524334v1?rss=1 Lyu, C. Bhimani, A. K. Draus, W. T. Weigel, R. Chen, S. 2023-01-19 doi:10.1101/2023.01.16.524334 Cold Spring Harbor Laboratory Press 2023-01-19 <![CDATA[ Spatial transcriptomics reveals unique gene expression changes in different brain regions after sleep deprivation ]]> https://biorxiv.org/content/10.1101/2023.01.18.524406v1?rss=1 View larger version (27K): org.highwire.dtl.DTLVardef@86d135org.highwire.dtl.DTLVardef@1110670org.highwire.dtl.DTLVardef@bdaddeorg.highwire.dtl.DTLVardef@e1d268_HPS_FORMAT_FIGEXP M_FIG C_FIG HighlightsO_LISpatial transcriptomics using the Visium platform reveals the transcriptional signature across the brain, recapitulating the anatomy of the mouse brain C_LIO_LISleep deprivation induces transcriptomic changes unique to each brain region C_LIO_LIThe hippocampus is the brain region impacted the most by acute sleep deprivation, with most differentially regulated genes significantly downregulated C_LIO_LIThe neocortex exhibits layer-specific changes in gene expression, with most differentially regulated genes significantly upregulated C_LIO_LIRegistration of spatial transcriptomic data to a common anatomical reference space (Allen Common Coordinate Framework) allows statistical analysis of gene expression across regions of the brain and for multi-sample analysis C_LI ]]> Vanrobaeys, Y. Peterson, Z. Walsh, E. Chatterjee, S. Lin, L.-C. Lyons, L. Nickl-Jockschat, T. Abel, T. 2023-01-19 doi:10.1101/2023.01.18.524406 Cold Spring Harbor Laboratory Press 2023-01-19 <![CDATA[ Mapping the spatial transcriptomic signature of the hippocampus during memory consolidation ]]> https://biorxiv.org/content/10.1101/2023.01.18.524576v1?rss=1 Vanrobeys, Y. Mukherjee, U. Langmack, L. Bahl, E. Lin, L.-C. Michaelson, J. J. Abel, T. Chatterjee, S. 2023-01-19 doi:10.1101/2023.01.18.524576 Cold Spring Harbor Laboratory Press 2023-01-19 <![CDATA[ Novel keto-alkyl-pyridinium antifungal molecules active in models of in vivo Candida albicans vascular catheter infection and ex vivo Candida auris skin colonization ]]> https://biorxiv.org/content/10.1101/2023.01.19.524835v1?rss=1 Beattie, S. R. Esan, T. Zaronowaki, R. Eix, E. Nett, J. E. Andes, D. R. Hagen, T. Krysan, D. J. 2023-01-20 doi:10.1101/2023.01.19.524835 Cold Spring Harbor Laboratory Press 2023-01-20 <![CDATA[ Mitochondrial citrate metabolism and efflux regulates trophoblast differentiation ]]> https://biorxiv.org/content/10.1101/2023.01.22.525071v1?rss=1 Mahr, R. M. Jena, S. Nashif, S. K. Nelson, A. B. Rauckhorst, A. J. Rome, F. I. Sheldon, R. D. Hughey, C. C. Puchalska, P. Gearhart, M. D. Taylor, E. B. Crawford, P. A. Wernimont, S. A. 2023-01-22 doi:10.1101/2023.01.22.525071 Cold Spring Harbor Laboratory Press 2023-01-22 <![CDATA[ Cortical Representation of Movement Across the Developmental Transition to Continuous Neural Activity ]]> https://biorxiv.org/content/10.1101/2023.01.22.525085v1?rss=1 Glanz, R. M. Sokoloff, G. Blumberg, M. S. 2023-01-22 doi:10.1101/2023.01.22.525085 Cold Spring Harbor Laboratory Press 2023-01-22 <![CDATA[ Staphylococcal secreted cytotoxins are competition sensing signals for Pseudomonas aeruginosa ]]> https://biorxiv.org/content/10.1101/2023.01.29.526047v1?rss=1 Wang, G. Z. Warren, E. A. Haas, A. L. Pena, A. S. Kiedrowski, M. R. Lomenick, B. Chou, T.-F. Bomberger, J. M. Tirrell, D. A. Limoli, D. H. 2023-01-29 doi:10.1101/2023.01.29.526047 Cold Spring Harbor Laboratory Press 2023-01-29 <![CDATA[ ARHGAP29 is required for keratinocyte proliferation and migration ]]> https://biorxiv.org/content/10.1101/2023.01.30.525978v1?rss=1 Reeb, T. Rhea, L. Adelizzi, E. Garnica, B. Dunnwald, E. Dunnwald, M. 2023-02-01 doi:10.1101/2023.01.30.525978 Cold Spring Harbor Laboratory Press 2023-02-01 <![CDATA[ Alpha-synuclein pre-formed fibrils injected into prefrontal cortex primarily impact cortical and subcortical structures and lead to restricted behavioral impacts ]]> https://biorxiv.org/content/10.1101/2023.01.31.526365v1?rss=1 Weber, M. A. de Choisy, G. Thangavel, R. Conlon, M. M. Abdelmotilib, H. A. Halhouli, O. Zhang, Q. Geerling, J. C. Narayanan, N. S. Aldridge, G. M. 2023-02-03 doi:10.1101/2023.01.31.526365 Cold Spring Harbor Laboratory Press 2023-02-03 <![CDATA[ Tubular Mitochondrial Pyruvate Carrier Disruption Elicits Redox Adaptations that Protect from Acute Kidney Injury ]]> https://biorxiv.org/content/10.1101/2023.01.31.526492v1?rss=1 Rauckhorst, A. Martinez, G. V. Andrade, G. M. Wen, H. Kim, J. Y. Simoni, A. Mapuskar, K. A. Rastogi, P. Steinbach, E. J. McCormick, M. L. Allen, B. G. Jackson, A. R. Pabla, N. S. Coleman, M. C. Spitz, D. R. Taylor, E. B. Zepeda-Orozco, D. 2023-01-31 doi:10.1101/2023.01.31.526492 Cold Spring Harbor Laboratory Press 2023-01-31 <![CDATA[ Functional Connectivity of the Cerebellar Vermis in Bipolar Disorder and Associations with Mood ]]> https://biorxiv.org/content/10.1101/2023.02.02.526878v1?rss=1 Saleem, A. Harmata, G. Jain, S. Voss, M. W. Fiedorowicz, J. G. Williams, A. J. Shaffer, J. J. Richards, J. G. Barsotti, E. J. Sathyaputri, L. Schmitz, S. L. Christensen, G. E. Long, J. D. Xu, J. Wemmie, J. A. Magnotta, V. 2023-02-02 doi:10.1101/2023.02.02.526878 Cold Spring Harbor Laboratory Press 2023-02-02 <![CDATA[ The Clustered Gamma Protocadherin Pcdhγc4 Isoform Regulates Cortical Interneuron Programmed Cell Death in the Mouse Cortex. ]]> https://biorxiv.org/content/10.1101/2023.02.03.526887v1?rss=1 Mancia Leon, W. R. Steffen, D. M. Dale-Huang, F. Rakela, B. Breevoort, A. Romero-Rodriguez, R. Hasenstaub, A. R. Stryker, M. P. Weiner, J. A. Alvarez-Buylla, A. 2023-02-04 doi:10.1101/2023.02.03.526887 Cold Spring Harbor Laboratory Press 2023-02-04 <![CDATA[ Dissecting 16p11.2 hemi-deletion to study sex-specific striatal phenotypes of neurodevelopmental disorders ]]> https://biorxiv.org/content/10.1101/2023.02.09.527866v1?rss=1 Kim, J. Vanrobaeys, Y. Peterson, Z. Kelvington, B. Gaine, M. E. Nickl-Jockschat, T. Abel, T. 2023-02-09 doi:10.1101/2023.02.09.527866 Cold Spring Harbor Laboratory Press 2023-02-09 <![CDATA[ Interference with the HNF4-dependent gene regulatory network diminishes ER stress in hepatocytes ]]> https://biorxiv.org/content/10.1101/2023.02.09.527889v1?rss=1 Shah, A. Huck, I. Duncan, K. Gansemer, E. R. Apte, U. Stamnes, M. A. Rutkowski, D. T. 2023-02-09 doi:10.1101/2023.02.09.527889 Cold Spring Harbor Laboratory Press 2023-02-09 <![CDATA[ PI3Kδ inhibition potentiates glucocorticoids in B-ALL by decreased receptor phosphorylation and enhanced gene regulation ]]> https://biorxiv.org/content/10.1101/2023.02.10.527869v1?rss=1 Zimmerman, J. A. O. Fang, M. Pufall, M. A. 2023-02-12 doi:10.1101/2023.02.10.527869 Cold Spring Harbor Laboratory Press 2023-02-12 <![CDATA[ Conflicts are represented in a cognitive space to reconcile domain-general and domain-specific cognitive control ]]> https://biorxiv.org/content/10.1101/2023.02.13.528292v1?rss=1 Yang, G. Wu, H. Li, Q. Liu, X. Fu, Z. Jiang, J. 2023-02-14 doi:10.1101/2023.02.13.528292 Cold Spring Harbor Laboratory Press 2023-02-14 <![CDATA[ The mitochondrial regulation of smooth muscle cell proliferation in type 2 diabetes ]]> https://biorxiv.org/content/10.1101/2023.02.15.528765v1?rss=1 Grumbach, I. M. Koval, O. M. Nguyen, E. Mittauer, D. J. Ait-Aissa, K. Chinchankar, W. Qian, L. Madesh, M. Dai, D.-F. 2023-02-16 doi:10.1101/2023.02.15.528765 Cold Spring Harbor Laboratory Press 2023-02-16 <![CDATA[ Characterization of the First Turtle Organoids: A Model for Investigating Unique Adaptations with Biomedical Potential ]]> https://biorxiv.org/content/10.1101/2023.02.20.527070v1?rss=1 Zdyrski, C. Gabriel, V. Gessler, T. B. Ralston, A. Sifuentes-Romero, I. Kundu, D. Honold, S. Wickham, H. Topping, N. E. Sahoo, D. K. Bista, B. Tamplin, J. Ospina, O. Pineyro, P. Meyerholz, D. K. Allenspach, K. Mochel, J. P. Valenzuela, N. 2023-02-21 doi:10.1101/2023.02.20.527070 Cold Spring Harbor Laboratory Press 2023-02-21 <![CDATA[ Cerebellar Morphological Differences in Bipolar Disorder Type I ]]> https://biorxiv.org/content/10.1101/2023.02.20.528549v1?rss=1 Harmata, G. I. S. Barsotti, E. J. Casten, L. G. Fiedorowicz, J. G. Williams, A. J. Shaffer, J. J. Richards, J. G. Sathyaputri, L. Schmitz, S. L. Christensen, G. E. Long, J. D. Gaine, M. E. Xu, J. Michaelson, J. J. Wemmie, J. A. Magnotta, V. A. 2023-02-21 doi:10.1101/2023.02.20.528549 Cold Spring Harbor Laboratory Press 2023-02-21 <![CDATA[ Distinct neurochemical influences on fMRI response polarity in the striatum ]]> https://biorxiv.org/content/10.1101/2023.02.20.529283v1?rss=1 Cerri, D. H. Albaugh, D. L. Walton, L. R. Katz, B. Wang, T.-W. Chao, T.-H. H. Zhang, W. Nonneman, R. J. Jiang, J. Lee, S.-H. Etkin, A. Hall, C. N. Stuber, G. D. Shih, Y.-Y. I. 2023-02-21 doi:10.1101/2023.02.20.529283 Cold Spring Harbor Laboratory Press 2023-02-21 <![CDATA[ Dynamic Changes in Macrophage Polarization during the Resolution Phase of Periodontal Disease ]]> https://biorxiv.org/content/10.1101/2023.02.20.529313v1?rss=1 Uttamani, J. Kulkarni, V. Valverde, A. Naqvi, R. Nares, S. Naqvi, A. 2023-02-21 doi:10.1101/2023.02.20.529313 Cold Spring Harbor Laboratory Press 2023-02-21 <![CDATA[ A computational model of MGUS progression to Multiple Myeloma identifies optimum screening strategies and their effects on mortality ]]> https://biorxiv.org/content/10.1101/208645v1?rss=1 Altrock, P. M. Ferlic, J. Galla, T. Tomasson, M. H. Michor, F. 2017-10-25 doi:10.1101/208645 Cold Spring Harbor Laboratory Press 2017-10-25 <![CDATA[ Unbiased association and expression studies identify novel genes for tooth development ]]> https://biorxiv.org/content/10.1101/209684v1?rss=1 Williams, M. Biguetti, C. Romero-Bustillos, M. Maheshwari, K. Dinckan, N. Cavalla, F. Liu, X. Silva, R. Akyalcin, S. Uyguner, Z. O. Vieira, A. Amendt, B. A. Fakhrouri, W. D. Letra, A. 2017-10-26 doi:10.1101/209684 Cold Spring Harbor Laboratory Press 2017-10-26 <![CDATA[ Lineage specific histories of Mycobacterium tuberculosis dispersal in Africa and Eurasia ]]> https://biorxiv.org/content/10.1101/210161v1?rss=1 O'Neill, M. B. Kitchen, A. Zarley, A. Aylward, W. Eldholm, V. Pepperell, C. S. 2017-10-27 doi:10.1101/210161 Cold Spring Harbor Laboratory Press 2017-10-27 <![CDATA[ Causal Mapping of Emotion Networks in the Human Brain: Framework and Preliminary Findings ]]> https://biorxiv.org/content/10.1101/214486v1?rss=1 Dubois, J. Oya, H. Tyszka, J. M. Howard, M. Eberhardt, F. Adolphs, R. 2017-11-05 doi:10.1101/214486 Cold Spring Harbor Laboratory Press 2017-11-05 <![CDATA[ Biophysical models reveal the relative importance of transporter proteins and impermeant anions in chloride homeostasis ]]> https://biorxiv.org/content/10.1101/216150v1?rss=1 Düsterwald, K. M. Currin, C. B. Burman, R. J. Akerman, C. J. Kay, A. R. Raimondo, J. V. 2017-11-08 doi:10.1101/216150 Cold Spring Harbor Laboratory Press 2017-11-08 <![CDATA[ Prefrontal D1 dopamine-receptor neurons and delta resonance in interval timing ]]> https://biorxiv.org/content/10.1101/216473v1?rss=1 Kim, Y.-C. Narayanan, N. 2017-11-10 doi:10.1101/216473 Cold Spring Harbor Laboratory Press 2017-11-10 <![CDATA[ Collective cell behaviour in mechanosensing of substrate thickness ]]> https://biorxiv.org/content/10.1101/228478v1?rss=1 Tusan, C. G. Man, Y. H. Zarkoob, H. Johnson, D. A. Andriotis, O. G. Thurner, P. J. Yang, S. Sander, E. A. Gentleman, E. Sengers, B. Evans, N. 2017-12-04 doi:10.1101/228478 Cold Spring Harbor Laboratory Press 2017-12-04 <![CDATA[ Sex in the wild: why field-based studies play a critical role in resolving the problem of sex ]]> https://biorxiv.org/content/10.1101/235465v1?rss=1 Neiman, M. Meirmans, P. Schwander, T. Meirmans, S. 2017-12-18 doi:10.1101/235465 Cold Spring Harbor Laboratory Press 2017-12-18 <![CDATA[ Consortium genome-wide meta-analysis for childhood dental caries traits ]]> https://biorxiv.org/content/10.1101/238824v1?rss=1 Haworth, S. Shungin, D. van der Tas, J. T. Vucic, S. Medina Gomez, C. Yakimov, V. Feenstra, B. Shaffer, J. R. Lee, M. K. Standl, M. Thiering, E. Wang, C. Bonnelykke, K. Waage, J. Jessen, L. E. Norrisgaard, P. E. Joro, R. Seppälä, I. Raitakari, O. Dudding, T. Grgic, O. Ongkosuwito, E. Vierola, A. Eloranta, A.-M. West, N. X. Thomas, S. J. McNeil, D. W. Levy, S. M. Slayton, R. Nohr, E. A. Lehtimäki, T. Lakka, T. Bisgaard, H. Pennell, C. Kühnisch, J. Marazita, M. L. Melbye, M. Geller, F. Rivadeneira, F. Wolvius, E. B. Franks, 2017-12-25 doi:10.1101/238824 Cold Spring Harbor Laboratory Press 2017-12-25 <![CDATA[ Substrate deformations induce directed keratinocyte migration ]]> https://biorxiv.org/content/10.1101/249037v1?rss=1 Zarkoob, H. Chinnathambi, S. Selby, J. C. Sander, E. A. 2018-01-17 doi:10.1101/249037 Cold Spring Harbor Laboratory Press 2018-01-17 <![CDATA[ Detection of de novo copy number deletions from targeted sequencing of trios ]]> https://biorxiv.org/content/10.1101/252833v1?rss=1 Fu, J. M. Leslie, E. J. Scott, A. F. Murray, J. C. Marazita, M. L. Beaty, T. H. Scharpf, R. B. Ruczinski, I. 2018-01-24 doi:10.1101/252833 Cold Spring Harbor Laboratory Press 2018-01-24 <![CDATA[ In Vivo Measurements of the Frequency-Dependent Impedance of the Spinal Cord ]]> https://biorxiv.org/content/10.1101/252965v1?rss=1 Utz, M. Miller, J. W. Reddy, C. G. Wilson, S. Abode-Iyamah, k. O. Fredericks, D. C. Gillies, G. T. Howard, M. A. 2018-01-25 doi:10.1101/252965 Cold Spring Harbor Laboratory Press 2018-01-25 <![CDATA[ Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders ]]> https://biorxiv.org/content/10.1101/257311v1?rss=1 Walters, R. K. Adams, M. J. Adkins, A. E. Aliev, F. Bacanu, S.-A. Batzler, A. Bertelsen, S. Biernacka, J. Bigdeli, T. B. Chen, L.-S. Clarke, T.-K. Chou, Y.-L. Degenhardt, F. Docherty, A. R. Fontanillas, P. Foo, J. Fox, L. Frank, J. Giegling, I. Gordon, S. Hack, L. -, Hartz, S. M. Heilmann-Heimbach, S. Herms, S. Hodgkinson, C. Hoffmann, P. Hottenga, J.-J. Kennedy, M. A. Alanne-Kinnunen, M. Konte, B. Lahti, J. Lahti-Pulkkinen, M. Ligthart, L. Loukola, A.-M. Maher, B. S. Mbarek, H. McIntosh, A. M. McQueen, M. B. Milaneschi, Y. Palviainen, T. Pearson, J. 2018-03-10 doi:10.1101/257311 Cold Spring Harbor Laboratory Press 2018-03-10 <![CDATA[ Two Novel Forms of ERG Oscillation in Drosophila: Age and Activity Dependence ]]> https://biorxiv.org/content/10.1101/259952v1?rss=1 Ueda, A. Woods, S. McElree, I. O'Harrow, T. C. D. G. Inman, C. Thenuwara, S. Aftab, M. Iyengar, A. 2018-02-05 doi:10.1101/259952 Cold Spring Harbor Laboratory Press 2018-02-05 <![CDATA[ Endothelia extrude apoptotic cells to maintain a constant barrier ]]> https://biorxiv.org/content/10.1101/268946v1?rss=1 Mleynek, T. Li, D. Rosenblatt, J. Redd, M. J. Chan, A. Gu, Y. 2018-02-21 doi:10.1101/268946 Cold Spring Harbor Laboratory Press 2018-02-21 <![CDATA[ Quantifying the unquantifiable: why Hymenoptera -- not Coleoptera -- is the most speciose animal order ]]> https://biorxiv.org/content/10.1101/274431v1?rss=1 Forbes, A. A. Bagley, R. K. Beer, M. A. Hippee, A. C. Widmayer, H. A. 2018-03-02 doi:10.1101/274431 Cold Spring Harbor Laboratory Press 2018-03-02 <![CDATA[ Inferring Disease Risk Genes from Sequencing Data in Multiplex Pedigrees Through Sharing of Rare Variants ]]> https://biorxiv.org/content/10.1101/285874v1?rss=1 Bureau, A. Begum, F. Taub, M. A. Hetmanski, J. Parker, M. M. Albacha-Hejazi, H. Scott, A. F. Murray, J. C. Marazita, M. L. Bailey-Wilson, J. E. Beaty, T. H. Ruczinski, I. 2018-03-20 doi:10.1101/285874 Cold Spring Harbor Laboratory Press 2018-03-20 <![CDATA[ Processing of Auditory Novelty Across the Cortical Hierarchy: An Intracranial Electrophysiology Study ]]> https://biorxiv.org/content/10.1101/290106v1?rss=1 Nourski, K. V. Steinschneider, M. Rhone, A. E. Kawasaki, H. Howard, M. A. Banks, M. I. 2018-03-27 doi:10.1101/290106 Cold Spring Harbor Laboratory Press 2018-03-27 <![CDATA[ Genetic sequences are two-dimensional ]]> https://biorxiv.org/content/10.1101/299867v1?rss=1 Erives, A. J. 2018-04-11 doi:10.1101/299867 Cold Spring Harbor Laboratory Press 2018-04-11 <![CDATA[ Mode of Growth and Temperature Dependence on Expression of Atrazine-degrading Genes in Pseudomonas sp. strain ADP Biofilms ]]> https://biorxiv.org/content/10.1101/302877v1?rss=1 Delcau, M. A. Henry, V. Pattee, E. Peeples, T. L. 2018-04-17 doi:10.1101/302877 Cold Spring Harbor Laboratory Press 2018-04-17 <![CDATA[ FMRIPrep: a robust preprocessing pipeline for functional MRI ]]> https://biorxiv.org/content/10.1101/306951v1?rss=1 Esteban, O. Markiewicz, C. Blair, R. W. Moodie, C. Isik, A. I. Erramuzpe Aliaga, A. Kent, J. Goncalves, M. DuPre, E. Snyder, M. Oya, H. Ghosh, S. Wright, J. Durnez, J. Poldrack, R. Gorgolewski, K. J. 2018-04-25 doi:10.1101/306951 Cold Spring Harbor Laboratory Press 2018-04-25 <![CDATA[ Expert Specification of the ACMG/AMP Variant Interpretation Guidelines for Genetic Hearing Loss ]]> https://biorxiv.org/content/10.1101/313734v1?rss=1 Oza, A. DiStefano, M. Hemphill, S. Cushman, B. Grant, A. Siegert, R. Shen, J. Chapin, A. Boczek, N. Schimmenti, L. Murry, J. Hasadsri, L. Nara, K. Kenna, M. Booth, K. Azaiez, H. Griffith, A. Avraham, K. Kremer, H. Rehm, H. Amr, S. Abou Tayoun, A. The ClinGen Hearing Loss Expert Workgroup, 2018-05-08 doi:10.1101/313734 Cold Spring Harbor Laboratory Press 2018-05-08 <![CDATA[ RsmV a small non-coding regulatory RNA in Pseudomonas aeruginosa that sequesters RsmA and RsmF from target mRNAs ]]> https://biorxiv.org/content/10.1101/315341v1?rss=1 10-fold higher affinity than RsmY and RsmZ. Gene expression studies revealed that the temporal expression pattern of RsmV differs from RsmW, RsmY, and RsmZ. These findings suggest that each sRNA may play distinct roles in controlling RsmA and RsmF activity.nnIMPORTANCEThe role of RsmF in post-transcriptional control of gene expression remains enigmatic. While numerous rsmA-dependent phenotypes are more pronounced in an rsmAF double mutant, deletion of rsmF alone has only modest effects. Understanding mechanisms that control RsmF activity will provide insight into additional roles for RsmF. In the current study we identify RsmV as an sRNA that controls RsmA and RsmF activity, and show that RsmV, RsmW, RsmY, and RsmZ are differentially expressed during growth. ]]> Janssen, K. H. Diaz, M. Gode, C. J. Wolfgang, M. C. Yahr, T. L. 2018-05-07 doi:10.1101/315341 Cold Spring Harbor Laboratory Press 2018-05-07 <![CDATA[ Similarity judgments and cortical visual responses reflect different properties of object and scene categories in naturalistic images ]]> https://biorxiv.org/content/10.1101/316554v1?rss=1 King, M. Groen, I. I. A. Steel, A. Kravitz, D. Baker, C. 2018-05-10 doi:10.1101/316554 Cold Spring Harbor Laboratory Press 2018-05-10 <![CDATA[ Genetic determinants of risk and survival in pulmonary arterial hypertension ]]> https://biorxiv.org/content/10.1101/317164v1?rss=1 16 years versus 8 years), compared to patients homozygous for the alternative allele.nnInterpretationWe have found that common genetic variation at loci in HLA-DPA1/DPB1 and an enhancer near SOX17 are associated with PAH. Impairment of Sox17 function may be more common in PAH than suggested by rare mutations in SOX17. Allelic variation at HLA-DPB1 stratifies PAH patients for survival following diagnosis, with implications for future therapeutic trial design.nnFundingUK NIHR, BHF, UK MRC, Dinosaur Trust, NIH/NHLBI, ERS, EMBO, Wellcome Trust, EU, AHA, ACClinPharm, Netherlands CVRI, Dutch Heart Foundation, Dutch Federation of UMC, Netherlands OHRD and RNAS, German DFG, German BMBF, APH Paris, Inserm, Universite Paris-Sud, and French ANR. ]]> Rhodes, C. Batai, K. Bleda, M. Haimel, M. Southgate, L. Germain, M. Pauciulo, M. Hadinnapola, C. Girerd, B. Arora, A. Knight, J. Hanscombe, K. Karnes, J. Kaakinen, M. Gall, H. Ulrich, A. Harbaum, L. Aman, J. Cebola, I. Ferrer, J. NIHR BioResource Rare Diseases Consortium, UK PAH Cohort Study Consortium, US PAH Biobank Consortium, Ahmad, F. Amouyel, P. Archer, S. Argula, R. Austin, E. Badesch, D. Bakshi, S. Barnett, C. Benza, R. Bhatt, N. Bogaard, H. Burger, C. Chakinala, M. Church, C. Coghlan, J. Condliffe, R. Corris, P. Danesino, C. Debette, S. 2018-05-16 doi:10.1101/317164 Cold Spring Harbor Laboratory Press 2018-05-16 <![CDATA[ Support for the dominance theory in Drosophila transcriptomes ]]> https://biorxiv.org/content/10.1101/321455v1?rss=1 Llopart, A. Brud, E. Pettie, N. Comeron, J. M. 2018-05-14 doi:10.1101/321455 Cold Spring Harbor Laboratory Press 2018-05-14 <![CDATA[ Neuronal Modulation of Brown Adipose Activity Through Perturbation of White Adipocyte Lipogenesis ]]> https://biorxiv.org/content/10.1101/324160v1?rss=1 Guilherme, A. Pedersen, D. J. Henriques, F. Bedard, A. H. Henchey, E. Kelly, M. Rahmouni, K. Morgan, D. A. Czech, M. P. 2018-05-16 doi:10.1101/324160 Cold Spring Harbor Laboratory Press 2018-05-16 <![CDATA[ Its not you, its me: Corollary discharge in precerebellar nuclei of sleeping infant rats ]]> https://biorxiv.org/content/10.1101/329540v1?rss=1 Blumberg, M. S. Sokoloff, G. Mukherjee, D. 2018-05-24 doi:10.1101/329540 Cold Spring Harbor Laboratory Press 2018-05-24 <![CDATA[ Genome Wide Interaction Studies Identify Sex-Specific Risk Alleles for Nonsyndromic Orofacial Clefts ]]> https://biorxiv.org/content/10.1101/329599v1?rss=1 Carlson, J. Nidey, N. Butali, A. Buxo Martinez, C. Christensen, K. Deleyiannis, F. Hecht, J. Field, L. L. Moreno-Uribe, L. Orioli, I. Poletta, F. Padilla, C. Vieira, A. Weinberg, S. Wehby, G. Feingold, E. Murray, J. Marazita, M. Leslie, E. 2018-05-24 doi:10.1101/329599 Cold Spring Harbor Laboratory Press 2018-05-24 <![CDATA[ Developmental \"awakening\" of primary motor cortex to the sensory consequences of movement ]]> https://biorxiv.org/content/10.1101/331983v1?rss=1 Dooley, J. C. Blumberg, M. S. 2018-05-28 doi:10.1101/331983 Cold Spring Harbor Laboratory Press 2018-05-28 <![CDATA[ A novel method for systematic genetic analysis and visualization of phenotypic heterogeneity applied to orofacial clefts ]]> https://biorxiv.org/content/10.1101/332270v1?rss=1 Carlson, J. Anand, D. Buxo, C. Christensen, K. Deleyiannis, F. Hecht, J. Moreno-Uribe, L. Orioli, I. Padilla, C. Shaffer, J. Vieira, A. Wehby, G. Weinberg, S. Murray, J. Beaty, T. Saadi, I. Lachke, S. Marazita, M. Feingold, E. Leslie, E. 2018-05-28 doi:10.1101/332270 Cold Spring Harbor Laboratory Press 2018-05-28 <![CDATA[ Pancreatic adenocarcinoma human organoids share structural and genetic features with primary tumors ]]> https://biorxiv.org/content/10.1101/338897v1?rss=1 Romero Calvo, I. Weber, C. R. Ray, M. Brown, M. A. Kirby, K. J. Nandi, R. K. Long, T. M. Sparrow, S. M. Ugolkov, A. V. Qiang, W. Zhang, Y. Brunetti, T. M. Kindler, H. L. Segal, J. P. Rzhetsky, A. Mazar, A. P. Buschmann, M. M. Weichselbaum, R. R. Rogin, K. K. White, K. P. 2018-06-04 doi:10.1101/338897 Cold Spring Harbor Laboratory Press 2018-06-04 <![CDATA[ A nonsense mutation in Myelin Protein Zero causes congenital hypomyelination neuropathy through altered P0 membrane targeting and gain of abnormal function ]]> https://biorxiv.org/content/10.1101/352112v1?rss=1 Fratta, P. Ornaghi, F. Dati, G. Zambroni, D. Saveri, P. Belin, S. D'Adamo, P. Shy, M. Quattrini, A. Feltri, M. L. Wrabetz, L. 2018-06-27 doi:10.1101/352112 Cold Spring Harbor Laboratory Press 2018-06-27 <![CDATA[ Maintenance of homeostatic plasticity at the Drosophila neuromuscular junction requires continuous IP3-directed signaling ]]> https://biorxiv.org/content/10.1101/356436v1?rss=1 James, T. D. Zwiefelhofer, D. J. Frank, C. A. 2018-06-27 doi:10.1101/356436 Cold Spring Harbor Laboratory Press 2018-06-27 <![CDATA[ GWAS of QRS Duration Identifies New Loci Specific to Hispanic/Latino Populations ]]> https://biorxiv.org/content/10.1101/363457v1?rss=1 Swenson, B. Louie, T. Lin, H. J. Mendez-Gairldez, R. Below, J. E. Laurie, C. C. Kerr, K. F. Highland, H. Thornton, T. A. Ryckman, K. K. Kooperberg, C. Soliman, E. Z. Seyerle, A. A. Guo, X. Taylor, K. D. Yao, J. Heckbert, S. R. Darbar, D. Petty, L. E. McKnight, B. Cheng, S. Bello, N. A. Whitsel, E. A. Hanis, C. L. Nalls, M. A. Evans, D. S. Rotter, J. I. Sofer, T. Avery, C. Sotoodehnia, N. 2018-07-06 doi:10.1101/363457 Cold Spring Harbor Laboratory Press 2018-07-06 <![CDATA[ Mutant lamins cause mechanically-induced nuclear envelope rupture, DNA damage, and DNA-PK activation in muscle ]]> https://biorxiv.org/content/10.1101/364778v1?rss=1 Earle, A. J. Kirby, T. J. Fedorchak, G. R. Isermann, P. Patel, J. Iruvanti, S. Bonne, G. Wallrath, L. L. Lammerding, J. 2018-07-07 doi:10.1101/364778 Cold Spring Harbor Laboratory Press 2018-07-07 <![CDATA[ Genome-wide analysis in UK Biobank identifies over 100 QTLs associated with muscle mass variability in middle age individuals ]]> https://biorxiv.org/content/10.1101/370312v1?rss=1 Hernandez Cordero, A. I. Gregory, J. S. Douglas, A. Lionikas, A. 2018-07-16 doi:10.1101/370312 Cold Spring Harbor Laboratory Press 2018-07-16 <![CDATA[ Forecasting autism gene discovery with machine learning and genome-scale data ]]> https://biorxiv.org/content/10.1101/370601v1?rss=1 Brueggeman, L. Koomar, T. Michaelson, J. 2018-07-16 doi:10.1101/370601 Cold Spring Harbor Laboratory Press 2018-07-16 <![CDATA[ Atropselective Oxidation of 2,2′,3,3′,4,6′-Hexachlorobiphenyl (PCB 132) to Hydroxylated Metabolites by Human Liver Microsomes: Involvement of Arene Oxide Intermediates ]]> https://biorxiv.org/content/10.1101/373837v1?rss=1 0.8). The second eluting atropisomer of 5'-132 was enriched in all microsomal preparations investigated. EF values differed slightly between single donor HLM preparations (EF = 0.84 to 0.96 for 3'-140; EF = 0.12 to 0.19 for 5'-132). These findings suggest that there are inter-individual differences in the atropselective biotransformation of PCB 132 to OH-PCBs in humans that may affect neurotoxic outcomes. ]]> Uwimana, E. Li, X. Yeung, C. Patterson, E. V. Lehmler, H.-J. 2018-07-23 doi:10.1101/373837 Cold Spring Harbor Laboratory Press 2018-07-23 <![CDATA[ The Landscape of Enteric Pathogen Exposure of Young Children in Public Domains of Low-Income, Urban Kenya: The Influence of Exposure Pathway and Spatial Range of Play on Multi-Pathogen Exposure Risks ]]> https://biorxiv.org/content/10.1101/388140v1?rss=1 Medgyesi, D. N. Sewell, D. Senesac, R. Cumming, O. Mumma, J. Baker, K. K. 2018-08-09 doi:10.1101/388140 Cold Spring Harbor Laboratory Press 2018-08-09 <![CDATA[ Spatial dynamics of brain functional domains: A new avenue to study time-varying brain function ]]> https://biorxiv.org/content/10.1101/391094v1?rss=1 Iraji, A. Fu, Z. Damarajua, E. Belger, A. Ford, J. M. McEwen, S. Mathalon, D. H. Mueller, B. A. Pearlson, G. D. Potkin, S. G. Preda, A. Turner, J. A. Vaidya, J. G. van Erp, T. G. M. Calhoun, V. D. 2018-08-13 doi:10.1101/391094 Cold Spring Harbor Laboratory Press 2018-08-13 <![CDATA[ Large-Scale Annotation of Histopathology Images from Social Media ]]> https://biorxiv.org/content/10.1101/396663v1?rss=1 Schaumberg, A. J. Juarez, W. Choudhury, S. J. Pastrian, L. G. Pritt, B. S. Prieto Pozuelo, M. Sotillo Sanchez, R. Ho, K. Zahra, N. Sener, B. D. Yip, S. Xu, B. Annavarapu, S. R. Morini, A. Jones, K. A. Rosado-Orozco, K. Sirintrapun, S. J. Aly, M. Fuchs, T. J. 2018-08-21 doi:10.1101/396663 Cold Spring Harbor Laboratory Press 2018-08-21 <![CDATA[ The genetic architecture of the human cerebral cortex ]]> https://biorxiv.org/content/10.1101/399402v1?rss=1 Grasby, K. L. Jahanshad, N. Painter, J. N. Colodro-Conde, L. Bralten, J. Hibar, D. P. Lind, P. A. Pizzagalli, F. Ching, C. R. McMahon, M. A. Shatokhina, N. Zsembik, L. C. P. Agartz, I. Alhusaini, S. Almeida, M. A. Alnaes, D. Amlien, I. K. Andersson, M. Ard, T. Armstrong, N. J. Ashley-Koch, A. Bernard, M. Brouwer, R. M. Buimer, E. E. Bülow, R. Bürger, C. Cannon, D. M. Chakravarty, M. Chen, Q. Cheung, J. W. Couvy-Duchesne, B. Dale, A. M. Dalvie, S. de Araujo, T. K. de Zubicaray, G. I. de Zwarte, S. M. den Braber, A. Doan, N. T. Dohm, K. Ehrlich, S. Engel 2018-09-03 doi:10.1101/399402 Cold Spring Harbor Laboratory Press 2018-09-03 <![CDATA[ Engineered transfer RNAs for suppression of premature termination codons ]]> https://biorxiv.org/content/10.1101/400127v1?rss=1 Lueck, J. D. Yoon, J. S. Perales-Puchalt, A. Mackey, A. L. Infield, D. T. Behlke, M. A. Pope, M. R. Weiner, D. B. Skach, W. R. McCray, P. B. Ahern, C. A. 2018-08-27 doi:10.1101/400127 Cold Spring Harbor Laboratory Press 2018-08-27 <![CDATA[ Do mechanical strain magnitude and rate drive bone adaptation in adult women? A 12-month prospective study. ]]> https://biorxiv.org/content/10.1101/421156v1?rss=1 Troy, K. Mancuso, M. Johnson, J. Wu, Z. Schnitzer, T. J. Butler, T. A. 2018-09-18 doi:10.1101/421156 Cold Spring Harbor Laboratory Press 2018-09-18 <![CDATA[ Comparative analysis of PknB inhibitors for reactivity and toxicity ]]> https://biorxiv.org/content/10.1101/423061v1?rss=1 Wlodarchak, N. Beczkiewicz, J. Seitz, S. Ye, Z. Feltenberger, J. Davis, J. M. Striker, R. T. 2018-09-20 doi:10.1101/423061 Cold Spring Harbor Laboratory Press 2018-09-20 <![CDATA[ Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration ]]> https://biorxiv.org/content/10.1101/423897v1?rss=1 Liu, X. Helenius, D. Skotte, L. Beaumont, R. N. Wielscher, M. Geller, F. Juodakis, J. Mahajan, A. Bradfield, J. P. Lin, F. T. J. Vogelezang, S. Bustamante, M. Ahluwalia, T. S. Pitkänen, N. Wang, C. A. Bacelis, J. Borges, M. C. Zhang, G. Bedell, B. A. Rossi, R. M. Skogstrand, K. Peng, S. Early Growth Genetics (EGG) Consortium, iPSYCH-BROAD Working Group, Thompson, W. K. Appadurai, V. Lawlor, D. A. Kalliala, I. Power, C. McCarthy, M. I. Boyd, H. A. Marazita, M. L. Hakonarson, H. Hayes, M. G. Scholtens, D. M. Rivadeneira, F. Jaddoe, V. W. V. Vinding, R. K 2018-09-23 doi:10.1101/423897 Cold Spring Harbor Laboratory Press 2018-09-23 <![CDATA[ The spatial chronnectome reveals a dynamic interplay between functional segregation and integration ]]> https://biorxiv.org/content/10.1101/427450v1?rss=1 Iraji, A. DeRamus, T. Lewis, N. Yaesoubi, M. Stephen, J. M. Erhardt, E. Belger, A. Ford, J. McEwen, S. Mathalon, D. Mueller, B. Pearlson, G. Potkin, S. Preda, A. Turner, J. Vaidya, J. van Erp, T. Calhoun, V. 2018-09-25 doi:10.1101/427450 Cold Spring Harbor Laboratory Press 2018-09-25 <![CDATA[ The microbial basis of impaired wound healing: differential roles for pathogens, \"bystanders\", and strain-level diversification in clinical outcomes ]]> https://biorxiv.org/content/10.1101/427567v1?rss=1 Kalan, L. Meisel, J. S. Loesche, M. A. Horwinski, J. Soaita, I. Chen, X. Gardner, S. E. Grice, E. A. 2018-09-27 doi:10.1101/427567 Cold Spring Harbor Laboratory Press 2018-09-27 <![CDATA[ Brg1 controls neurosensory cell fate commitment and differentiation in the mammalian inner ear ]]> https://biorxiv.org/content/10.1101/434159v1?rss=1 Xu, P.-X. Xu, J. Li, J. Loh, Y.-H. E. Zhang, T. Jiang, H. Fritzsch, B. Ramakrishnan, A. Shen, L. 2018-10-03 doi:10.1101/434159 Cold Spring Harbor Laboratory Press 2018-10-03 <![CDATA[ Dynamics and Selective Remodeling of the DNA Binding Domains of RPA ]]> https://biorxiv.org/content/10.1101/435636v1?rss=1 Pokhrel, N. Caldwell, C. C. Corless, E. I. Tillison, E. A. Tibbs, J. Jocic, N. Tabei, A. Wold, M. S. Spies, M. Antony, E. 2018-10-04 doi:10.1101/435636 Cold Spring Harbor Laboratory Press 2018-10-04 <![CDATA[ Comparisons of a Novel Air Sampling Filter Material, Wash Buffers and Extraction Methods in the Detection and Quantification of Influenza Virus ]]> https://biorxiv.org/content/10.1101/441154v1?rss=1 0.05). Viral RNA concentrations were significantly different across extraction methods for all comparisons (p-values < 0.05). Our results demonstrated that the novel polystyrene filter material resulted in the highest concentration of extracted RNA compared to the commonly used polytetrafluoroethylene and polyvinylchloride, which we speculate may be related to the chemical composition of the filter material (e.g., polystyrene is an aromatic hydrocarbon whereas polytetrafluoroethylene and polyvinylchloride contain more polar, and thus potentially reactive, carbon-halogen bonds). Air sampling did not have an effect on viral RNA recovery. Using Hanks Balanced Salt Solution with QIAamp Viral RNA Mini Kit, and Phosphate-buffered saline with the Trizol extraction, resulted in the most viral RNA recovery. ]]> Thedell, T. Boles, C. L. Cwiertny, D. W. Brown, G. D. Qian, J. Nonnenmann, M. W. 2018-10-11 doi:10.1101/441154 Cold Spring Harbor Laboratory Press 2018-10-11 <![CDATA[ Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors ]]> https://biorxiv.org/content/10.1101/442756v1?rss=1 Warrington, N. M. Beaumont, R. Horikoshi, M. Day, F. R. Helgeland, O. Laurin, C. Bacelis, J. Peng, S. Hao, K. Feenstra, B. Wood, A. R. Mahajan, A. Tyrrell, J. Robertson, N. Rayner, N. W. Qiao, Z. Moen, G.-H. O. Vaudel, M. Marsit, C. J. Chen, J. Nodzenski, M. Schnurr, T. M. Zafarmand, M. H. Bradfield, J. P. Grarup, N. Kooijman, M. N. Li-Gao, R. Geller, F. Ahluwalia, T. S. Paternoster, L. Rueedi, R. Huikari, V. Hottenga, J.-J. Lyytikäinen, L.-P. Cavadino, A. Metrustry, S. Cousminer, D. L. Wu, Y. Thiering, E. Wang, C. A. Have, C. T. Vilor-Tejedor, N. Jos 2018-10-17 doi:10.1101/442756 Cold Spring Harbor Laboratory Press 2018-10-17 <![CDATA[ Calculating the Effects of Autism Risk Gene Variants on Dysfunction of Biological Processes Identifies Clinically-Useful Information ]]> https://biorxiv.org/content/10.1101/449819v1?rss=1 Veatch, O. J. Mazzotti, D. R. Sutcliffe, J. S. Schultz, R. T. Abel, T. Tunc, B. Assouline, S. G. Brodkin, E. S. Michaelson, J. J. Nickl-Jockschat, T. Warren, Z. E. Malow, B. A. Pack, A. I. 2018-10-22 doi:10.1101/449819 Cold Spring Harbor Laboratory Press 2018-10-22 <![CDATA[ Impact of genetic variations on the human brain: when and where? ]]> https://biorxiv.org/content/10.1101/461814v1?rss=1 Vervier, K. Brueggeman, L. Michaelson, J. 2018-11-05 doi:10.1101/461814 Cold Spring Harbor Laboratory Press 2018-11-05 <![CDATA[ Long-distance dispersal, ice sheet dynamics, and mountaintop isolation underlie the genetic structure of glacier ice worms ]]> https://biorxiv.org/content/10.1101/463521v1?rss=1 1,500 km) areas of unsuitable habitat. In this study, we analyzed genome-scale sequence data for most of the known ice worm range. We found clear support for divergence between populations along the Pacific Coast and the inland flanks of the Coast Mountains (mean FST = 0.60), likely precipitated by episodic ice sheet expansion and contraction during the Pleistocene. We also found support for LDD of ice worms from Alaska to Vancouver Island, perhaps mediated by migrating birds. Our results highlight the power of genomic data for disentangling complex biogeographic patterns, including the presence of LDD. ]]> Hotaling, S. Shain, D. H. Lang, S. A. Bagley, R. K. M., L. Weisrock, D. W. Kelley, J. L. 2018-11-08 doi:10.1101/463521 Cold Spring Harbor Laboratory Press 2018-11-08 <![CDATA[ TIM-1 SERVES AS A NONREDUNDANT RECEPTOR FOR EBOLA VIRUS, ENHANCING VIREMIA AND PATHOGENESIS ]]> https://biorxiv.org/content/10.1101/466102v1?rss=1 Brunton, B. Rogers, K. Phillips, E. K. Brouillette, R. B. Bouls, R. Butler, N. S. Maury, W. 2018-11-08 doi:10.1101/466102 Cold Spring Harbor Laboratory Press 2018-11-08 <![CDATA[ Adult Canine Intestinal Derived Organoids: A Novel In Vitro System for Translational Research in Comparative Gastroenterology ]]> https://biorxiv.org/content/10.1101/466409v1?rss=1 Chandra, L. Borcherding, D. C. Kingsbury, D. Atherly, T. Ambrosini, Y. M. Bourgois-Mochel, A. Yuan, W. Kimber, M. Qi, Y. Wang, Q. Wannemuehler, M. Ellinwood, N. M. Snella, E. Martin, M. Skala, M. Meyerholz, D. Estes, M. Fernandez-Zapico, M. E. Jergens, A. E. Mochel, J. P. Allenspach, K. 2018-11-09 doi:10.1101/466409 Cold Spring Harbor Laboratory Press 2018-11-09 <![CDATA[ Genetic variation in the Major Histocompatibility Complex and association with depression ]]> https://biorxiv.org/content/10.1101/469023v1?rss=1 Glanville, K. P. Coleman, J. R. I. Hanscombe, K. B. Euesden, J. Choi, S. W. Purves, K. L. Breen, G. Air, T. M. Andlauer, T. F. M. Baune, B. T. Binder, E. B. Blackwood, D. H. R. Boomsma, D. I. Buttenschon, H. N. Colodro-Conde, L. Dannlowski, U. Direk, N. Dunn, E. C. Forstner, A. J. de Geus, E. J. C. Grabe, H. J. Hamilton, S. P. Jones, I. Jones, L. A. Knowles, J. A. Kutalik, Z. Levinson, D. F. Lewis, G. Lind, P. A. Lucae, S. Magnusson, P. K. McGuffin, P. McIntosh, A. M. Milaneschi, Y. Mors, O. Mostafavi, S. Müller-Myhsok, B. Pedersen, N. L. Penninx, B. W. J 2018-11-19 doi:10.1101/469023 Cold Spring Harbor Laboratory Press 2018-11-19 <![CDATA[ A xylose-inducible expression system and a CRISPRi-plasmid for targeted knock-down of gene expression in Clostridioides difficile ]]> https://biorxiv.org/content/10.1101/476796v1?rss=1 Muh, U. Pannullo, A. G. Weiss, D. S. Ellermeier, C. D. 2018-11-22 doi:10.1101/476796 Cold Spring Harbor Laboratory Press 2018-11-22 <![CDATA[ Transcriptional heterogeneity in cancer-associated regulatory T cells is predictive of survival. ]]> https://biorxiv.org/content/10.1101/478628v1?rss=1 Borcherding, N. Ahmed, K. K. Voigt, A. P. Vishwakarma, A. Kolb, R. Kluz, P. Pandey, G. Gibson-Corley, K. N. Klesney-Tait, J. Zhu, Y. Lu, J. Lu, J. Huang, X. Cheng, J. Zheng, S. G. Wu, X. Zakharia, Y. Zhang, W. 2018-11-26 doi:10.1101/478628 Cold Spring Harbor Laboratory Press 2018-11-26 <![CDATA[ Distinctions among electroconvulsion- and proconvulsant-induced seizure discharges and native motor patterns during flight and grooming: Quantitative spike pattern analysis in Drosophila flight muscles ]]> https://biorxiv.org/content/10.1101/481234v1?rss=1 Lee, J. Iyengar, A. Wu, C.-F. 2018-11-28 doi:10.1101/481234 Cold Spring Harbor Laboratory Press 2018-11-28 <![CDATA[ Activity-is better than connectivity-neurofeedback training in Huntington’s disease ]]> https://biorxiv.org/content/10.1101/481903v1?rss=1 Papoutsi, M. Magerkurth, J. Josephs, O. Pepes, S. E. Ibitoye, T. Reilmann, R. Hunt, N. Payne, E. Weiskopf, N. Langbehn, D. Rees, G. Tabrizi, S. J. 2018-11-29 doi:10.1101/481903 Cold Spring Harbor Laboratory Press 2018-11-29 <![CDATA[ Enteric Pathogen Diversity in Infant Foods in Low-income Neighborhoods Of Kisumu, Kenya ]]> https://biorxiv.org/content/10.1101/493213v1?rss=1 Tsai, K. Simiyu, S. Mumma, J. Aseyo, R. E. Cumming, O. Dreibelbis, R. Baker, K. 2018-12-11 doi:10.1101/493213 Cold Spring Harbor Laboratory Press 2018-12-11 <![CDATA[ Sex-dependent differences in pain and sleep in a porcine model of Neurofibromatosis type 1 ]]> https://biorxiv.org/content/10.1101/495358v1?rss=1 Khanna, R. Moutal, A. White, K. Chefdeville, A. Negrao de Assis, P. Cai, S. Swier, V. J. Bellampalli, S. S. Giunta, M. D. Darbro, B. W. Quelle, D. E. Sieren, J. C. Wallace, M. R. Rogers, C. S. Meyerholz, D. K. Weimer, J. M. 2018-12-20 doi:10.1101/495358 Cold Spring Harbor Laboratory Press 2018-12-20 <![CDATA[ In trans variant calling reveals enrichment for compound heterozygous variants in genes involved in neuronal development and growth. ]]> https://biorxiv.org/content/10.1101/496133v1?rss=1 Cox, A. J. Grady, F. Velez, G. Mahajan, V. B. Ferguson, P. J. Kitchen, A. Darbro, B. W. Bassuk, A. G. 2018-12-13 doi:10.1101/496133 Cold Spring Harbor Laboratory Press 2018-12-13 <![CDATA[ Episodic evolution of a eukaryotic NADK repertoire of ancient provenance ]]> https://biorxiv.org/content/10.1101/507913v1?rss=1 Vickman, O. Erives, A. J. 2018-12-31 doi:10.1101/507913 Cold Spring Harbor Laboratory Press 2018-12-31 <![CDATA[ Validating indicators of CNS disorders in a swine model of neurological disease ]]> https://biorxiv.org/content/10.1101/514398v1?rss=1 Swier, V. J. White, K. Meyerholz, D. K. Chefdeville, A. Khanna, R. Sieren, J. C. Quelle, D. E. Weimer, J. M. 2019-01-09 doi:10.1101/514398 Cold Spring Harbor Laboratory Press 2019-01-09 <![CDATA[ A keeper of many crypts: the parasitoid Euderus set manipulates the behavior of a taxonomically diverse array of oak gall wasp species ]]> https://biorxiv.org/content/10.1101/516104v1?rss=1 Ward, A. K. G. Khodor, O. S. Egan, S. P. Weinersmith, K. L. Forbes, A. A. 2019-01-09 doi:10.1101/516104 Cold Spring Harbor Laboratory Press 2019-01-09 <![CDATA[ Exome sequencing of 457 autism families recruited online provides evidence for novel ASD genes ]]> https://biorxiv.org/content/10.1101/516625v1?rss=1 Feliciano, P. Zhou, X. Astrovskaya, I. Turner, T. Wang, T. Brueggeman, L. Barnard, R. Hsieh, A. Snyder, L. G. Muzny, D. Sabo, A. The SPARK Consortium, Gibbs, R. Eichler, E. O'Roak, B. Michaelson, J. Volfovsky, N. Shen, Y. Chung, W. 2019-01-09 doi:10.1101/516625 Cold Spring Harbor Laboratory Press 2019-01-09 <![CDATA[ Nascent transcript analysis of glucocorticoid crosstalk with TNF defines primary and cooperative inflammatory repression ]]> https://biorxiv.org/content/10.1101/524975v1?rss=1 Sasse, S. K. Gruca, M. Allen, M. A. Kadiyala, V. Song, T. Gally, F. Gupta, A. Pufall, M. A. Dowell, R. D. Gerber, A. N. 2019-01-18 doi:10.1101/524975 Cold Spring Harbor Laboratory Press 2019-01-18 <![CDATA[ Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson's Disease ]]> https://biorxiv.org/content/10.1101/528463v1?rss=1 Bryois, J. Skene, N. G. Folkmann Hansen, T. Kogelman, L. J. A. Watson, H. J. Eating Disorders Working Group of the Psychiatric Genomics Consortium, International Headache Genetics Consortium, The 23andMe Research Team, Brueggeman, L. Breen, G. Bulik, C. M. Arenas, E. Hjerling-Leffler, J. Sullivan, P. F. 2019-01-23 doi:10.1101/528463 Cold Spring Harbor Laboratory Press 2019-01-23 <![CDATA[ Huntington's disease onset is determined by length of uninterrupted CAG, not encoded polyglutamine, and is modified by DNA maintenance mechanisms ]]> https://biorxiv.org/content/10.1101/529768v1?rss=1 Genetic Modifiers of Huntington's Disease (GeM-HD) Consortium, Lee, J.-M. Correia, K. Loupe, J. Kim, K.-H. Barker, D. Hong, E. P. Chao, M. J. Long, J. D. Lucente, D. Vonsattel, J.-P. Mouro Pinto, R. Abu Elneel, K. Ramos, E. M. Mysore, J. S. Gillis, T. Wheeler, V. C. MacDonald, M. E. Gusella, J. F. Massey, T. McAllister, B. Medway, C. Stone, T. C. Hall, L. Jones, L. Holmans, P. Kwak, S. Ehrhardt, A. Sampaio, C. Ciosi, M. Maxwell, A. Chatzi, A. Monckton, D. G. Orth, M. Landwehrmeyer, G. B. Paulsen, J. S. Dorsey, E. R. Shoulson, I. Myers, R. H. 2019-01-24 doi:10.1101/529768 Cold Spring Harbor Laboratory Press 2019-01-24 <![CDATA[ Impoverished auditory cues fail to engage brain networks controlling spatial selective attention ]]> https://biorxiv.org/content/10.1101/533117v1?rss=1 Deng, Y. Choi, I. Shinn-Cunningham, B. G. Baumgartner, R. 2019-01-29 doi:10.1101/533117 Cold Spring Harbor Laboratory Press 2019-01-29 <![CDATA[ Single-molecule long-read sequencing reveals the chromatin basis of gene expression ]]> https://biorxiv.org/content/10.1101/533158v1?rss=1 Wang, Y. Wang, A. Liu, Z. Thurman, A. Powers, L. S. Zou, M. Hefel, A. Li, Y. Zabner, J. Au, K. F. 2019-01-29 doi:10.1101/533158 Cold Spring Harbor Laboratory Press 2019-01-29 <![CDATA[ ClinGen Expert Clinical Validity Curation of 164 Hearing Loss Gene-Disease Pairs ]]> https://biorxiv.org/content/10.1101/534040v1?rss=1 DiStefano, M. T. Hemphill, S. E. Oza, A. M. Siegert, R. K. Gant, A. R. Hughes, M. Y. Cushman, B. J. Azaiez, H. Booth, K. T. Chapin, A. Duzkale, H. Matsunaga, T. Shen, J. Zhang, W. Kenna, M. Schimmenti, L. Tekin, M. Rehm, H. L. Abou Tayoun, A. N. Amr, S. S. ClinGen Hearing Loss Clinical Domain Working Group, 2019-01-29 doi:10.1101/534040 Cold Spring Harbor Laboratory Press 2019-01-29 <![CDATA[ Occupation and Parkinson disease in Women's Health Initiative Observational Study ]]> https://biorxiv.org/content/10.1101/535732v1?rss=1 Burstyn, I. LaCroix, A. Z. Litvan, I. Wallace, R. B. Checkoway, H. 2019-02-01 doi:10.1101/535732 Cold Spring Harbor Laboratory Press 2019-02-01 <![CDATA[ Genome of the parasitoid wasp Diachasma alloeum, an emerging model for ecological speciation and transitions to asexual reproduction ]]> https://biorxiv.org/content/10.1101/545277v1?rss=1 Tvedte, E. Walden, K. K. McElroy, K. E. Werren, J. Forbes, A. A. Hood, G. R. Logsdon, J. M. Feder, J. L. Robertson, H. M. 2019-02-11 doi:10.1101/545277 Cold Spring Harbor Laboratory Press 2019-02-11 <![CDATA[ Machine Learning Methods to Identify Genetic Correlates of Radiation-Associated Contralateral Breast Cancer in the WECARE Study ]]> https://biorxiv.org/content/10.1101/547422v1?rss=1 1 Gy to the contralateral breast. A previously reported algorithm, preconditioned random forest regression, was applied to predict the risk of developing RCBC. The resulting model produced an area under the curve of 0.62 (p=0.04) on hold-out validation data. The biological analysis identified the cyclic AMP-mediated signaling and Ephrin-A as significant biological correlates, which were previously shown to influence cell survival after radiation in an ATM-dependent manner. The key connected genes and proteins that are identified in this analysis were previously identified as relevant to breast cancer, radiation response, or both. In summary, machine learning/bioinformatics methods applied to genome-wide genotyping data have great potential to reveal plausible biological correlates associated with the risk of RCBC. ]]> Lee, S. Liang, X. Woods, M. Reiner, A. Thomas, D. Concannon, P. Bernstein, L. Lynch, C. Boice, J. Deasy, J. Bernstein, J. Oh, J. H. 2019-02-12 doi:10.1101/547422 Cold Spring Harbor Laboratory Press 2019-02-12 <![CDATA[ A Deficiency in SUMOylation Activity Disrupts Multiple Pathways Leading to Neural Tube and Heart Defects in Xenopus Embryos ]]> https://biorxiv.org/content/10.1101/549105v1?rss=1 Bertke, M. M. Dubiak, K. M. Cronin, L. Zeng, E. Huber, P. W. 2019-02-13 doi:10.1101/549105 Cold Spring Harbor Laboratory Press 2019-02-13 <![CDATA[ Structural Insights into Hearing Loss Genetics from Polarizable Protein Repacking ]]> https://biorxiv.org/content/10.1101/556258v1?rss=1 Tollefson, M. R. Litman, J. Qi, G. Marini, R. J. O'Connell, C. E. Wipfler, M. J. Bernabe, H. V. Tollefson, W. T. Casavant, T. L. Braun, T. A. Smith, R. J. Schnieders, M. J. 2019-02-21 doi:10.1101/556258 Cold Spring Harbor Laboratory Press 2019-02-21 <![CDATA[ Male evolution under relaxed selection: Evidence for degeneration in sperm produced by male snails from asexual lineages ]]> https://biorxiv.org/content/10.1101/556357v1?rss=1 Jalinsky, J. Logsdon, J. M. Neiman, M. 2019-02-21 doi:10.1101/556357 Cold Spring Harbor Laboratory Press 2019-02-21 <![CDATA[ Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile ]]> https://biorxiv.org/content/10.1101/559393v1?rss=1 Noordam, R. Bos, M. M. Wang, H. Winkler, T. W. Bentley, A. R. Kilpeläinen, T. de Vries, P. S. Sung, Y. J. Schwander, K. Cabe, B. E. Manning, A. Aschard, H. Brown, M. R. Chen, H. Franceschini, N. Musani, S. K. Richard, M. Vojinovic, D. Aslibekyan, S. Bartz, T. M. de las Fuentes, L. Feitosa, M. Horimoto, A. R. Ilkov, M. Kho, M. Kraja, A. Li, C. Lim, E. Liu, Y. Mook-Kanamori, D. O. Rankinen, T. Tajuddin, S. M. van der Spek, A. Wang, Z. Marten, J. Laville, V. Alver, M. Evangelou, E. Graff, M. E. He, M. Kühnel, B. Lyytikäinen, L.-P. Marques-Vidal, P. No 2019-02-25 doi:10.1101/559393 Cold Spring Harbor Laboratory Press 2019-02-25 <![CDATA[ Src-dependent DBL family members drive resistance to vemurafenib in human melanoma ]]> https://biorxiv.org/content/10.1101/561597v1?rss=1 Feddersen, C. R. Schillo, J. L. Varzavand, A. Vaughn, H. R. Wadsworth, L. S. Voigt, A. P. Zhu, E. Y. Jennings, B. M. Mullen, S. A. Bobera, J. Riordan, J. D. Stipp, C. S. Dupuy, A. J. 2019-02-26 doi:10.1101/561597 Cold Spring Harbor Laboratory Press 2019-02-26 <![CDATA[ Non-Invasive Assays of Cochlear Synaptopathy -- Candidates and Considerations ]]> https://biorxiv.org/content/10.1101/565655v1?rss=1 Bharadwaj, H. M. Mai, A. R. Simpson, J. M. Choi, I. Heinz, M. G. Shinn-Cunningham, B. G. 2019-03-05 doi:10.1101/565655 Cold Spring Harbor Laboratory Press 2019-03-05 <![CDATA[ A Role for Gαz in regulating seizure susceptibility ]]> https://biorxiv.org/content/10.1101/567628v1?rss=1 Hultman, R. Boms, O. Mague, S. D. Hughes, D. Nadler, V. Dzirasa, K. Casey, P. J. 2019-03-06 doi:10.1101/567628 Cold Spring Harbor Laboratory Press 2019-03-06 <![CDATA[ Loss of tau and Fyn reduces compensatory effects of MAP2 for tau and reveals a Fyn-independent effect of tau on glutamate-induced Ca2+ response ]]> https://biorxiv.org/content/10.1101/567776v1?rss=1 Liu, G. Thangavel, R. Rysted, J. Kim, Y. Francis, M. B. Adams, E. Lin, Z. Taugher, R. J. Wemmie, J. A. Usachev, Y. M. Lee, G. 2019-03-04 doi:10.1101/567776 Cold Spring Harbor Laboratory Press 2019-03-04 <![CDATA[ Leishmania major degrades murine CXCL1 - an immune evasion strategy ]]> https://biorxiv.org/content/10.1101/571141v1?rss=1 Yorek, M. S. Poudel, B. Mazgaeen, L. Pope, R. M. Wilson, M. E. Gurung, P. 2019-03-07 doi:10.1101/571141 Cold Spring Harbor Laboratory Press 2019-03-07 <![CDATA[ Frontal cortex tracks surprise separately for different sensory modalities but engages a common inhibitory control mechanism ]]> https://biorxiv.org/content/10.1101/572081v1?rss=1 Wessel, J. R. Huber, D. E. 2019-03-08 doi:10.1101/572081 Cold Spring Harbor Laboratory Press 2019-03-08 <![CDATA[ Cardiorespiratory fitness predicts greater hippocampal volume and rate of episodic associative learning in older adults ]]> https://biorxiv.org/content/10.1101/578237v1?rss=1 Cole, R. C. Hazeltine, E. Weng, T. B. Wharff, C. DuBose, L. E. Schmid, P. Sigurdsson, G. Magnotta, V. A. Pierce, G. L. Voss, M. W. 2019-04-02 doi:10.1101/578237 Cold Spring Harbor Laboratory Press 2019-04-02 <![CDATA[ Pyridox(am)ine 5’-phosphate oxidase deficiency induces seizures in Drosophila melanogaster ]]> https://biorxiv.org/content/10.1101/580050v1?rss=1 A missense mutation in sgll - the Drosophila homolog of human PNPO (hPNPO) and found mutant (sgll95) flies exhibiting a lethal phenotype on a diet devoid of VB6. Here we report the establishment of both sgll95 and ubiquitous sgll knockdown (KD) flies as valid animal models of PNPO-deficiency-induced epilepsy. Both sgll95 and sgll KD flies exhibit spontaneous seizures before they die. Electrophysiological recordings reveal that seizures caused by PNPO deficiency have characteristics similar to that in flies treated with GABA antagonist picrotoxin. Both seizures and lethality are associated with low PLP levels and can be rescued by ubiquitous expression of wild-type sgll or hPNPO, suggesting the functional conservation of the PNPO enzyme between humans and flies. Results from cell type-specific sgll KD further demonstrate that PNPO in the brain is necessary for seizure prevention and survival. Our establishment of the first animal model of PNPO deficiency will lead to better understanding of VB6 biology, the PNPO gene and its mutations discovered in patients, and can be a cost-effective system to test therapeutic strategies. ]]> Chi, W. Iyengar, A. Albersen, M. Bosma, M. Verhoeven-Duif, N. M. Wu, C.-F. Zhuang, X. 2019-03-16 doi:10.1101/580050 Cold Spring Harbor Laboratory Press 2019-03-16 <![CDATA[ A sound-sensitive source of alpha oscillations in human non-primary auditory cortex ]]> https://biorxiv.org/content/10.1101/590323v1?rss=1 Billig, A. J. Herrmann, B. Rhone, A. E. Gander, P. E. Nourski, K. V. Snoad, B. F. Kovach, C. K. Kawasaki, H. Howard, M. A. Johnsrude, I. S. 2019-03-28 doi:10.1101/590323 Cold Spring Harbor Laboratory Press 2019-03-28 <![CDATA[ Environmental light is required for maintenance of long-term memory in Drosophila ]]> https://biorxiv.org/content/10.1101/592667v1?rss=1 Inami, S. Sato, S. Kondo, S. Tanimoto, H. Kitamoto, T. Sakai, T. 2019-03-30 doi:10.1101/592667 Cold Spring Harbor Laboratory Press 2019-03-30 <![CDATA[ UBR5 is a Novel E3 Ubiquitin Ligase involved in Skeletal Muscle Hypertrophy and Recovery from Atrophy ]]> https://biorxiv.org/content/10.1101/592980v1?rss=1 700,000 SNPs) demonstrated that the A alleles of rs10505025 and rs4734621 SNPs in the UBR5 gene were strongly associated with larger cross-sectional area of fast-twitch muscle fibres and favoured strength/power versus endurance/untrained phenotypes. Overall, we suggest that UBR5 is a novel E3 ubiquitin ligase that is inversely regulated to MuRF1/MAFbx, is epigenetically regulated, and is elevated at both the gene expression and protein level during recovery from skeletal muscle atrophy and hypertrophy.nnKey PointsO_LIWe have recently identified that a HECT domain E3 ubiquitin ligase, named UBR5, is altered epigenetically (via DNA methylation) after human skeletal muscle hypertrophy, where its gene expression is positively correlated with increasing lean leg mass after training and retraining.nC_LIO_LIIn the present study we extensively investigate this novel and uncharacterised E3 ubiquitin ligase (UBR5) in skeletal muscle atrophy, recovery from atrophy and injury, anabolism and hypertrophy.nC_LIO_LIWe demonstrated that UBR5 was epigenetically via altered DNA methylation during recovery from atrophy.nC_LIO_LIWe also determined that UBR5 was alternatively regulated versus well characterised E3 ligases, MuRF1/MAFbx, at the gene expression level during atrophy, recovery from atrophy and hypertrophy.nC_LIO_LIUBR5 also increased at the protein level during recovery from atrophy and injury, hypertrophy and during human muscle cell differentiation.nC_LIO_LIFinally, in humans, genetic variations of the UBR5 gene were strongly associated with larger fast-twitch muscle fibres and strength/power performance versus endurance/untrained phenotypes.nC_LI ]]> Seaborne, R. A. Hughes, D. C. Turner, D. C. Owens, D. J. Baehr, L. M. Gorski, P. Semenova, E. A. Borisov, O. V. Larin, A. K. Popov, D. V. Generozov, E. V. Sutherland, H. Ahmetov, I. I. Jarvis, J. C. Sue, B. C. Sharples, A. P. 2019-03-29 doi:10.1101/592980 Cold Spring Harbor Laboratory Press 2019-03-29 <![CDATA[ An axiomatic basis for maximal homology alignment ]]> https://biorxiv.org/content/10.1101/593228v1?rss=1 Erives, A. J. 2019-03-30 doi:10.1101/593228 Cold Spring Harbor Laboratory Press 2019-03-30 <![CDATA[ A simplified transposon mutagenesis method to perform phenotypic forward genetic screens in cultured cells ]]> https://biorxiv.org/content/10.1101/598474v1?rss=1 Feddersen, C. R. Wadsworth, L. S. Zhu, E. Y. Vaughn, H. R. Voigt, A. P. Riordan, J. D. Dupuy, A. J. 2019-04-05 doi:10.1101/598474 Cold Spring Harbor Laboratory Press 2019-04-05 <![CDATA[ Scopolamine and medial frontal stimulus-processing during interval timing ]]> https://biorxiv.org/content/10.1101/598862v1?rss=1 Zhang, Q. Jung, D. Larson, T. Kim, Y. Narayanan, N. 2019-04-05 doi:10.1101/598862 Cold Spring Harbor Laboratory Press 2019-04-05 <![CDATA[ Cancer cells resist mechanical destruction in the circulation via RhoA-myosin II axis ]]> https://biorxiv.org/content/10.1101/601039v1?rss=1 Moose, D. L. Krog, B. L. Zhao, L. Kim, T.-H. Williams-Perez, S. Burke, G. Rhodes, L. Vanneste, M. Breheny, P. Milhem, M. Stipp, C. S. Rowat, A. C. Henry, M. D. 2019-04-06 doi:10.1101/601039 Cold Spring Harbor Laboratory Press 2019-04-06 <![CDATA[ Interspecies signaling generates exploratory motility in Pseudomonas aeruginosa ]]> https://biorxiv.org/content/10.1101/607523v1?rss=1 Limoli, D. H. Donegan, N. P. Warren, E. A. Cheung, A. L. O'Toole, G. 2019-04-12 doi:10.1101/607523 Cold Spring Harbor Laboratory Press 2019-04-12 <![CDATA[ How delayed treatment benefits and harms would impact the optimal timing of statin initiation for cardiovascular primary prevention ]]> https://biorxiv.org/content/10.1101/608216v1?rss=1 Hayward, R. A. Schell, G. Robinson, J. G. Sussman, J. Lavieri, M. 2019-04-12 doi:10.1101/608216 Cold Spring Harbor Laboratory Press 2019-04-12 <![CDATA[ Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38+ macrophages ]]> https://biorxiv.org/content/10.1101/609438v1?rss=1 Covarrubias, A. J. Lopez-Dominguez, J. A. Perrone, R. Kale, A. Newman, J. Iyer, S. S. Schmidt, M. S. Kasler, H. G. Shin, K.-O. Lee, Y.-M. Ben-Sahra, I. Ott, M. Brenner, C. Campisi, J. Verdin, E. 2019-04-17 doi:10.1101/609438 Cold Spring Harbor Laboratory Press 2019-04-17 <![CDATA[ The effect of number of healthcare visits on study sample selection and prevalence estimates in electronic health record data ]]> https://biorxiv.org/content/10.1101/622761v1?rss=1 Rasmussen-Torvik, L. Furmanchuk, A. Stoddard, A. Osinski, K. Meuer, J. Smith, N. Chrischilles, E. Black, B. Kho, A. 2019-05-03 doi:10.1101/622761 Cold Spring Harbor Laboratory Press 2019-05-03 <![CDATA[ CaV3.1 channel pore pseudo-symmetry revealed by selectivity filter mutations in their domains I/II ]]> https://biorxiv.org/content/10.1101/626069v1?rss=1 Garza-Lopez, E. Aldana, A. Darszon, A. Nishigaki, T. Lopez-Gonzalez, I. 2019-05-02 doi:10.1101/626069 Cold Spring Harbor Laboratory Press 2019-05-02 <![CDATA[ Vascular endothelial growth factor (VEGF) expression and neuroinflammation is increased in the frontopolar cortex of individuals with autism spectrum disorder ]]> https://biorxiv.org/content/10.1101/627083v1?rss=1 Gnanasekaran, A. Kelchen, M. N. Brogden, N. K. Smith, R. M. 2019-05-03 doi:10.1101/627083 Cold Spring Harbor Laboratory Press 2019-05-03 <![CDATA[ Corticostriatal stimulation compensates for medial frontal inactivation during interval timing ]]> https://biorxiv.org/content/10.1101/628263v1?rss=1 Emmons, E. B. Kennedy, M. Kim, Y. Narayanan, N. S. 2019-05-05 doi:10.1101/628263 Cold Spring Harbor Laboratory Press 2019-05-05 <![CDATA[ Missense mutations in the MLKL brace region lead to lethal neonatal inflammation in mice and are present in high frequency in humans. ]]> https://biorxiv.org/content/10.1101/628370v1?rss=1 Hildebrand, J. Kauppi, M. Majewski, I. Liu, Z. Cox, A. Miyake, S. Hall, C. Petrie, E. Silk, M. Tanzer, M. Young, S. Garnish, S. Corbin, J. Stutz, M. Gangatirkar, P. Josefsson, E. Rigbye, K. Anderton, H. Rickard, J. Tripaydonis, A. Sheridan, J. Scerri, T. Czabotar, P. Zhang, J. G. Allison, C. Pellegrini, M. Tannahill, G. Hatchell, E. Wilson, T. Stockwell, D. de Graaf, C. Hilton, A. Silke, N. Spall, S. Chau, D. Athanasopoulos, V. Laxer, R. Bassuk, A. Darbro, B. Fiatarone Singh, M. Vlahovich, N. Hughes, D. Kovlovskaia, M. Ascher, D. Warnatz, K. Venhoff 2019-05-15 doi:10.1101/628370 Cold Spring Harbor Laboratory Press 2019-05-15 <![CDATA[ Frontal theta and beta oscillations during lower-limb movement in Parkinson’s disease ]]> https://biorxiv.org/content/10.1101/634808v1?rss=1 Singh, A. Cole, R. C. Espinoza, A. I. Brown, D. R. Cavanagh, J. F. Narayanan, N. 2019-05-10 doi:10.1101/634808 Cold Spring Harbor Laboratory Press 2019-05-10 <![CDATA[ Genome-wide association study of susceptibility to idiopathic pulmonary fibrosis ]]> https://biorxiv.org/content/10.1101/636761v1?rss=1 Allen, R. J. Guillen-Guio, B. Oldham, J. M. Ma, S.-F. Dressen, A. Paynton, M. L. Kraven, L. M. Obeidat, M. Li, X. Ng, M. Braybrooke, R. Molina-Molina, M. Hobbs, B. D. Putman, R. K. Sakornsakolpat, P. Booth, H. L. Fahy, W. A. Hart, S. P. Hill, M. R. Hirani, N. Hubbard, R. B. McAnulty, R. J. Millar, A. B. Navaratnam, V. Oballa, E. Parfrey, H. Saini, G. Whyte, M. K. Gudmundsson, G. Gudnason, V. Hatabu, H. Lederer, D. J. Manichaikul, A. Newell, J. D. O'Connor, G. T. Ortega, V. E. Xu, H. Fingerlin, T. E. Bosse, Y. Hao, K. Joubert, P. Nickle, D. C. Sin, D. 2019-05-14 doi:10.1101/636761 Cold Spring Harbor Laboratory Press 2019-05-14 <![CDATA[ Female meiotic drive preferentially segregates derived metacentric chromosomes in Drosophila ]]> https://biorxiv.org/content/10.1101/638684v1?rss=1 Stewart, N. B. Ahmed-Braimah, Y. H. Cerne, D. G. McAllister, B. 2019-05-24 doi:10.1101/638684 Cold Spring Harbor Laboratory Press 2019-05-24 <![CDATA[ Genetic overlap between psychiatric disorders and neuropsychiatric symptoms in HD ]]> https://biorxiv.org/content/10.1101/639658v1?rss=1 Ellis, N. Tee, A. McAllister, B. Massey, T. McLauchlan, D. Stone, T. Correia, K. Loupe, J. Kim, K.-H. Barker, D. Hong, E. P. Chao, M. J. Long, J. D. Lucente, D. Vonsattel, J. P. G. Mouro Pinto, R. Elneel, K. A. Ramos, E. M. Mysore, J. S. Gillis, T. Wheeler, V. C. Medway, C. Hall, L. Kwak, S. Ehrhardt, A. G. Sampaio, C. Ciosi, M. Maxwell, A. Chatzi, A. Monckton, D. Orth, M. Landwehrmeyer, G. B. Paulsen, J. S. Shoulson, I. Myers, R. Duijn, E. v. Rickards, H. MacDonald, M. Lee, J.-M. Gusella, J. F. Jones, L. Holmans, P. 2019-05-17 doi:10.1101/639658 Cold Spring Harbor Laboratory Press 2019-05-17 <![CDATA[ Methods Matter -- Standard Production Platforms For Recombinant AAV Can Produce Chemically And Functionally Distinct Vectors ]]> https://biorxiv.org/content/10.1101/640169v1?rss=1 Rumachik, N. G. Malaker, S. A. Poweleit, N. Maynard, L. H. Adams, C. M. Leib, R. D. Cirolia, G. Thomas, D. Stamnes, S. Holt, K. Sinn, P. May, A. P. Paulk, N. K. 2019-05-17 doi:10.1101/640169 Cold Spring Harbor Laboratory Press 2019-05-17 <![CDATA[ β-bursts reveal the trial-to-trial dynamics of movement initiation and cancellation ]]> https://biorxiv.org/content/10.1101/644682v1?rss=1 Wessel, J. R. 2019-05-21 doi:10.1101/644682 Cold Spring Harbor Laboratory Press 2019-05-21 <![CDATA[ Aberrant striatal oscillations after dopamine loss in parkinsonian non-human primates ]]> https://biorxiv.org/content/10.1101/650770v1?rss=1 Singh, A. Papa, S. M. 2019-05-26 doi:10.1101/650770 Cold Spring Harbor Laboratory Press 2019-05-26 <![CDATA[ Occupancy distributions of membrane proteins in heterogeneous liposome populations ]]> https://biorxiv.org/content/10.1101/657098v1?rss=1 Cliff, L. Chadda, R. Robertson, J. L. 2019-06-02 doi:10.1101/657098 Cold Spring Harbor Laboratory Press 2019-06-02 <![CDATA[ Modulation of post-traumatic immune response using anti-IL-1 therapy for improved visual outcomes ]]> https://biorxiv.org/content/10.1101/659581v1?rss=1 Evans, L. P. Woll, A. W. Wu, S. Todd, B. P. Hehr, N. N. Hedberg-Buenz, A. Anderson, M. G. Newell, E. A. Ferguson, P. J. Mahajan, V. B. Harper, M. M. Bassuk, A. G. 2019-06-04 doi:10.1101/659581 Cold Spring Harbor Laboratory Press 2019-06-04 <![CDATA[ Host carbon dioxide concentration is an independent stress for Cryptococcus neoformans that affects virulence and antifungal susceptibility ]]> https://biorxiv.org/content/10.1101/659789v1?rss=1 Krysan, D. J. Zhai, B. Beattie, S. R. Misel, K. M. Wellington, M. Lin, X. 2019-06-04 doi:10.1101/659789 Cold Spring Harbor Laboratory Press 2019-06-04 <![CDATA[ CEP290 myosin-tail homology domain is essential for protein confinement between inner and outer segments in photoreceptors ]]> https://biorxiv.org/content/10.1101/660738v1?rss=1 Datta, P. Hendrickson, B. Brendalen, S. Ruffcorn, A. Seo, S. 2019-06-05 doi:10.1101/660738 Cold Spring Harbor Laboratory Press 2019-06-05 <![CDATA[ Altered White Matter Microstructural Organization in Post-Traumatic Stress Disorder across 3,049 Adults: Results from the PGC-ENIGMA PTSD Consortium ]]> https://biorxiv.org/content/10.1101/677153v1?rss=1 Dennis, E. Disner, S. E. Fani, N. Salminen, L. E. Logue, M. Clarke-Rubright, E. K. Haswell, C. C. Averill, C. Baugh, L. A. Bomyea, J. Bruce, S. E. Cha, J. Choi, K. Davenport, N. D. Densmore, M. du Plessis, S. Forster, G. L. Frijling, J. L. Gonenc, A. Gruber, S. Grupe, D. W. Guenette, J. P. Hayes, J. Hofmann, D. Ipser, J. Jovanovic, T. Kelly, S. Kennis, M. Kinzel, P. Koch, S. B. Koerte, I. Koopowitz, S. Korgaonkar, M. Krystal, J. Lebois, L. A. Li, G. Magnotta, V. A. Manthey, A. May, G. J. Menefee, D. S. Nawijn, L. Nelson, S. M. Neufeld, R. W. Nitschke, 2019-06-20 doi:10.1101/677153 Cold Spring Harbor Laboratory Press 2019-06-20 <![CDATA[ Nicotinamide riboside augments the human skeletal muscle NAD+ metabolome and induces transcriptomic and anti-inflammatory signatures in aged subjects: a placebo-controlled, randomized trial ]]> https://biorxiv.org/content/10.1101/680462v1?rss=1 Elhassan, Y. S. Kluckova, K. Fletcher, R. Schmidt, M. Garten, A. Doig, C. Cartwright, D. Oakey, L. Burley, C. Jenkinson, N. Wilson, M. Lucas, S. Akerman, I. Seabright, A. Lai, Y.-C. Tennant, D. Nightingale, P. Wallis, G. Manolopoulos, K. Brenner, C. Philp, A. Lavery, G. G. 2019-06-28 doi:10.1101/680462 Cold Spring Harbor Laboratory Press 2019-06-28 <![CDATA[ Topographic specificity of alpha power during auditory spatial attention ]]> https://biorxiv.org/content/10.1101/681361v1?rss=1 Deng, Y. Choi, I. Shinn-Cunningham, B. 2019-06-24 doi:10.1101/681361 Cold Spring Harbor Laboratory Press 2019-06-24 <![CDATA[ Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure ]]> https://biorxiv.org/content/10.1101/682013v1?rss=1 Shah, S. Henry, A. Roselli, C. Lin, H. Sveinbjörnsson, G. Fatemifar, G. Hedman, A. K. Wilk, J. B. Morley, M. P. Chaffin, M. D. Helgadottir, A. Verweij, N. Dehghan, A. Almgren, P. Anderson, C. Aragam, K. G. Ärnlöv, J. Backman, J. D. Biggs, M. L. Bloom, H. L. Brandimarto, J. Broad AF Investigators, Brown, M. R. Buckbinder, L. Carey, D. J. Regeneron Genetics Center, Chasman, D. I. Chen, X. Chen, X. Chung, J. Chutkow, W. Cook, J. P. Delgado, G. E. Denaxas, S. Doney, A. S. Dörr, M. Dudley, S. C. Dunn, M. E. EchoGen Consortium, Engström, G. Esko, T. 2019-07-10 doi:10.1101/682013 Cold Spring Harbor Laboratory Press 2019-07-10 <![CDATA[ Synergistic interplay between PHF8 and HER2 signaling contributes to breast cancer development and drug resistance ]]> https://biorxiv.org/content/10.1101/682476v1?rss=1 Qi, H. H. Liu, Q. Borcherding, N. Shao, P. Maina, P. K. Zhang, W. 2019-06-25 doi:10.1101/682476 Cold Spring Harbor Laboratory Press 2019-06-25 <![CDATA[ Genetic research at the intersection of gender identity, sexual orientation, and mental health: community attitudes and recommendations for researchers ]]> https://biorxiv.org/content/10.1101/685982v1?rss=1 Thomas, T. R. Hofammann, D. McKenna, B. G. Michaelson, J. J. 2019-07-02 doi:10.1101/685982 Cold Spring Harbor Laboratory Press 2019-07-02 <![CDATA[ Presynaptic mitochondria volumes and complexity of subsynaptic distribution increase during development at a high-fidelity synapse ]]> https://biorxiv.org/content/10.1101/689653v1?rss=1 Thomas, C. I. Keine, C. Okayama, S. Satterfield, R. Musgrove, M. Guerrero-Given, D. Kamasawa, N. Young, S. M. 2019-07-03 doi:10.1101/689653 Cold Spring Harbor Laboratory Press 2019-07-03 <![CDATA[ Analysis of task-based functional MRI data preprocessed with fMRIPrep ]]> https://biorxiv.org/content/10.1101/694364v1?rss=1 Esteban, O. Ciric, R. Finc, K. Blair, R. W. Markiewicz, C. J. Moodie, C. A. Kent, J. D. Goncalves, M. DuPre, E. Gomez, D. E. Ye, Z. Salo, T. Valabregue, R. Amlien, I. K. Liem, F. Jacoby, N. Stojic, H. Cieslak, M. Urchs, S. Halchenko, Y. O. Ghosh, S. S. de la Vega, A. Yarkoni, T. Wright, J. A. Thompson, W. H. Poldrack, R. A. Gorgolewski, K. J. 2019-07-08 doi:10.1101/694364 Cold Spring Harbor Laboratory Press 2019-07-08 <![CDATA[ A screen for gene paralogies delineating evolutionary branching order of early Metazoa ]]> https://biorxiv.org/content/10.1101/704551v1?rss=1 Erives, A. J. Fritzsch, B. 2019-07-17 doi:10.1101/704551 Cold Spring Harbor Laboratory Press 2019-07-17 <![CDATA[ Activation of the Extracytoplasmic Function σ factor σP by β-lactams in Bacillus thuringiensis requires the site-2 protease RasP ]]> https://biorxiv.org/content/10.1101/707133v1?rss=1 Ho, T. D. Nauta, K. M. Muh, U. Ellermeier, C. D. 2019-07-18 doi:10.1101/707133 Cold Spring Harbor Laboratory Press 2019-07-18 <![CDATA[ Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction ]]> https://biorxiv.org/content/10.1101/712398v1?rss=1 Ntalla, I. Weng, L.-C. Cartwright, J. H. Hall, A. Sveinbjornsson, G. Tucker, N. R. Seung Young, C. Chaffin, M. D. Roselli, C. Barnes, M. R. Mifsud, B. Warren, H. R. Hayward, C. Marten, J. Cranley, J. J. Concas, M. P. Gasparini, P. Boutin, T. Kolcic, I. Polasek, O. Rudan, I. Araujo, N. M. Lima-Costa, M. F. Ribeiro, A. L. P. Souza, R. P. Tarazona-Santos, E. Giedraitis, V. Ingelsson, E. Mahajan, A. Morris, A. P. Del Greco M., F. Foco, L. Gogele, M. Hicks, A. A. Cook, J. P. Lind, L. Lindgren, C. M. Sundstrom, J. Nelson, C. P. Riaz, M. B. Samani, N. J. Sinag 2019-07-24 doi:10.1101/712398 Cold Spring Harbor Laboratory Press 2019-07-24 <![CDATA[ Genome-wide analysis of diet and gene interactions in Drosophila uncovers the glucose transporter, CG4607, as a diet-responsive gene. ]]> https://biorxiv.org/content/10.1101/718304v1?rss=1 James, D. E. Francis, D. Ghazanfar, S. Havula, E. Krycer, J. R. Senior, A. Minard, A. Y. Geddes, T. A. Weiss, F. Yang, J. Y. H. 2019-07-30 doi:10.1101/718304 Cold Spring Harbor Laboratory Press 2019-07-30 <![CDATA[ Pharmaco-genetic screen to uncover actin regulators targeted by prostaglandins during Drosophila oogenesis ]]> https://biorxiv.org/content/10.1101/722355v1?rss=1 Spracklen, A. J. Lamb, M. C. Groen, C. M. Tootle, T. L. 2019-08-01 doi:10.1101/722355 Cold Spring Harbor Laboratory Press 2019-08-01 <![CDATA[ Development of the mandibular curve of Spee and maxillary compensating curve: A finite element model ]]> https://biorxiv.org/content/10.1101/723429v1?rss=1 Marshall, S. Kruger, K. Franciscus, R. G. Southard, T. E. 2019-08-02 doi:10.1101/723429 Cold Spring Harbor Laboratory Press 2019-08-02 <![CDATA[ Epigenetics biomarkers of delirium: immune response, inflammatory response and cholinergic synaptic involvement evidenced by genome-wide DNA methylation analysis of delirious inpatients ]]> https://biorxiv.org/content/10.1101/729335v1?rss=1 Saito, T. Toda, H. Duncan, G. N. Jellison, S. S. Yu, T. Klisares, M. J. Daniel, S. Andreasen, A. Leyden, L. Hellman, M. Shinozaki, E. Lee, S. Yoshino, A. Cho, H. R. Shinozaki, G. 2019-08-08 doi:10.1101/729335 Cold Spring Harbor Laboratory Press 2019-08-08 <![CDATA[ DNA methylation change in neurotrophic genes with aging and delirium evidenced from three independent cohorts ]]> https://biorxiv.org/content/10.1101/730382v1?rss=1 Saito, T. Braun, P. R. Daniel, S. Jellison, S. S. Hellman, M. Shinozaki, E. Lee, S. Cho, H. R. Yoshino, A. Toda, H. Shinozaki, G. 2019-08-08 doi:10.1101/730382 Cold Spring Harbor Laboratory Press 2019-08-08 <![CDATA[ Fascin regulates protrusions and delamination to promote invasive, collective cell migration in vivo. ]]> https://biorxiv.org/content/10.1101/734475v1?rss=1 Lamb, M. C. Anliker, K. K. Tootle, T. L. 2019-08-13 doi:10.1101/734475 Cold Spring Harbor Laboratory Press 2019-08-13 <![CDATA[ Haplotype genetic score analysis in 10,734 mother/infant pairs reveals complex maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes and adult phenotypes ]]> https://biorxiv.org/content/10.1101/737106v1?rss=1 Chen, J. Bacelis, J. Navais, P. S. Srivastava, A. Juodakis, J. Rouse, A. Hallman, M. Teramo, K. Melbye, M. Feenstra, B. Freathy, R. M. Davey-Smith, G. Lawlor, D. A. Murray, J. C. Williams, S. M. Jacobsson, B. Muglia, L. J. Zhang, G. 2019-08-15 doi:10.1101/737106 Cold Spring Harbor Laboratory Press 2019-08-15 <![CDATA[ Hippocampal subfield volumes are uniquely affected in PTSD and depression: International analysis of 31 cohorts from the PGC-ENIGMA PTSD Working Group ]]> https://biorxiv.org/content/10.1101/739094v1?rss=1 Salminen, L. E. Sämann, P. G. Zheng, Y. Dennis, E. L. Clarke, E. K. Jahanshad, N. Iglesias, J. E. Whelan, C. D. Bruce, S. E. Hayes, J. P. Seedat, S. Averill, C. L. Baugh, L. A. Bomyea, J. Bright, J. Buckle, C. J. Choi, K. Davenport, N. D. Davidson, R. J. Densmore, M. Disner, S. G. du Plessis, S. Elman, J. A. Fani, N. Forster, G. L. Franz, C. E. Frijling, J. L. Gonenc, A. Gruber, S. A. Grupe, D. W. Guenette, J. P. Haswell, C. C. Hofmann, D. Hollifield, M. Hosseini, B. Hudson, A. R. Ipser, J. Jovanovic, T. Kennedy-Krage, A. Kennis, M. King, A. Kinzel, P. 2019-08-21 doi:10.1101/739094 Cold Spring Harbor Laboratory Press 2019-08-21 <![CDATA[ CRISPR/Cas9 interrogation of the mouse Pcdhg gene cluster reveals a crucial isoform-specific role for Pcdhgc4 ]]> https://biorxiv.org/content/10.1101/739508v1?rss=1 Garrett, A. M. Bosch, P. J. Steffen, D. M. Fuller, L. C. Marcucci, C. G. Koch, A. A. Bais, P. Weiner, J. A. Burgess, R. W. 2019-08-19 doi:10.1101/739508 Cold Spring Harbor Laboratory Press 2019-08-19 <![CDATA[ Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies ]]> https://biorxiv.org/content/10.1101/741512v1?rss=1 Munn-Chernoff, M. Johnson, E. C. Chou, Y.-L. Coleman, J. R. Thornton, L. M. Walters, R. K. Yilmaz, Z. Baker, J. Hubel, C. Gordon, S. Medland, S. Watson, H. Gaspar, H. A. Bryois, J. Hinney, A. Leppa, V. Mattheisen, M. Ripke, S. Yao, S. Giusti-Rodriguez, P. Hanscombe, K. B. Adan, R. Alredsson, L. Ando, T. Andreassen, O. A. Berrettini, W. Boehm, I. Boni, C. Boraska Perica, V. Buehren, K. Burghardt, R. Cassina, M. Cichon, S. Clementi, M. Cone, R. Courtet, P. Crow, S. Crowley, J. J. Danner, U. Davis, O. de Zwaan, M. Dedoussis, G. Degortes, D. DeSocio, J. 2019-08-23 doi:10.1101/741512 Cold Spring Harbor Laboratory Press 2019-08-23 <![CDATA[ Whole genome sequencing of orofacial cleft trios from the Gabriella Miller Kids First Pediatric Research Consortium identifies a new locus on chromosome 21 ]]> https://biorxiv.org/content/10.1101/743526v1?rss=1 Mukhopadhyay, N. Bishop, M. Mortillo, M. Chopra, P. Ketmanski, J. B. Taub, M. A. Moreno, L. M. Valencia-Ramirez, L. C. Restrepo, C. Wehby, G. L. Hecht, J. T. Deleyiannis, F. Butali, A. Weinberg, S. M. Beaty, T. H. Murray, J. C. Leslie, E. J. Feingold, E. Marazita, M. L. 2019-08-22 doi:10.1101/743526 Cold Spring Harbor Laboratory Press 2019-08-22 <![CDATA[ Polygenic Prediction of Substance Use Disorders in Clinical and Population Samples ]]> https://biorxiv.org/content/10.1101/748038v1?rss=1 Barr, P. B. Ksinan, A. Su, J. Johnson, E. C. Meyers, J. L. Wetherill, L. Latvala, A. Aleive, F. Chan, G. Kuperman, S. Nurnberger, J. Kamarajan, C. Anokhin, A. Agrawal, A. Rose, R. J. Edenberg, H. J. Schuckit, M. Kaprio, J. Dick, D. M. 2019-08-30 doi:10.1101/748038 Cold Spring Harbor Laboratory Press 2019-08-30 <![CDATA[ Exogenous alginate protects Staphylococcus aureus from killing by Pseudomonas aeruginosa ]]> https://biorxiv.org/content/10.1101/748459v1?rss=1 Price, C. E. Brown, D. G. Limoli, D. Phelan, V. O'Toole, G. 2019-08-28 doi:10.1101/748459 Cold Spring Harbor Laboratory Press 2019-08-28 <![CDATA[ Multiple separate cases of pseudogenized meiosis genes Msh4 and Msh5 in Eurotiomycete fungi: associations with Zip3 sequence evolution and homothallism, but not Pch2 losses ]]> https://biorxiv.org/content/10.1101/750497v1?rss=1 Savelkoul, E. Toll, C. D. Benassi, N. D. Logsdon, J. M. 2019-08-31 doi:10.1101/750497 Cold Spring Harbor Laboratory Press 2019-08-31 <![CDATA[ Gradual decrease in the inter-population diversity of HIV-1 Env among group M lineages worldwide ]]> https://biorxiv.org/content/10.1101/753285v1?rss=1 Han, C. Johnson, J. M. Dong, R. Kandula, R. Kort, A. J. Wong, M. Yang, T. Breheny, P. J. Brown, G. D. Haim, H. 2019-09-04 doi:10.1101/753285 Cold Spring Harbor Laboratory Press 2019-09-04 <![CDATA[ Divergent Cl-and H + pathways underlie transport coupling and gating in CLC exchangers and channels ]]> https://biorxiv.org/content/10.1101/753954v1?rss=1 Accardi, A. Leisle, L. Xu, Y. Fortea, E. Galpin, J. D. Vien, M. Ahern, C. A. Berneche, S. 2019-09-05 doi:10.1101/753954 Cold Spring Harbor Laboratory Press 2019-09-05 <![CDATA[ Cross-Sectional and Longitudinal Validation of Serum Neurofilament Light Chain (NfL) as a Biomarker of Parkinson’s Disease Progression ]]> https://biorxiv.org/content/10.1101/762237v1?rss=1 Mollenhauer, B. Dakna, D. Liu, T.-Y. Galasko, D. Foroud, T. Zetterberg, H. Schade, S. Gera, R. Wang, W. Gao, F. Kruse, N. Frasier, M. Chahine, L. Coffey, C. S. Singleton, A. B. Simuni, T. Weintraub, D. Seibyl, J. Toga, A. W. Tanner, C. M. Kieburtz, K. Marek, K. Siderowf, A. Cedarbaum, J. M. Hutten, S. J. Trenkwalder, C. Graham, D. 2019-09-11 doi:10.1101/762237 Cold Spring Harbor Laboratory Press 2019-09-11 <![CDATA[ Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration ]]> https://biorxiv.org/content/10.1101/764100v1?rss=1 Wert, K. Velez, G. Vijayalakshmi, K. Shankar, V. Sengillo, J. Zare, R. N. Bassuk, A. G. Tsang, S. H. Mahajan, V. B. 2019-09-10 doi:10.1101/764100 Cold Spring Harbor Laboratory Press 2019-09-10 <![CDATA[ Polarity protein distribution on the metaphase furrow regulates hexagon dominated plasma membrane organization in syncytial Drosophila embryos ]]> https://biorxiv.org/content/10.1101/770453v1?rss=1 Dey, B. Mitra, D. Das, T. Sherlekar, A. Balaji, R. Rikhy, R. 2019-09-21 doi:10.1101/770453 Cold Spring Harbor Laboratory Press 2019-09-21 <![CDATA[ Causal links between parietal alpha activity and spatial auditory attention ]]> https://biorxiv.org/content/10.1101/775718v1?rss=1 Deng, Y. Reinhart, R. M. G. Choi, I. Shinn-Cunningham, B. G. 2019-09-19 doi:10.1101/775718 Cold Spring Harbor Laboratory Press 2019-09-19 <![CDATA[ A tissue-specific collaborative mixed model for jointly analyzing multiple tissues in transcriptome-wide association studies ]]> https://biorxiv.org/content/10.1101/789396v1?rss=1 Shi, X. Chai, X. Yang, Y. Cheng, Q. Jiao, Y. Huang, J. Yang, C. Liu, J. 2019-10-01 doi:10.1101/789396 Cold Spring Harbor Laboratory Press 2019-10-01 <![CDATA[ Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fragmentation and loss in retinal ganglion cells ]]> https://biorxiv.org/content/10.1101/790139v1?rss=1 Edwards, G. Perkins, G. A. Kim, K.-Y. Kong, Y. Lee, Y. Choi, S.-H. Skowronska-Krawczyk, D. Weinreb, R. N. Zangwill, L. Strack, S. Ju, W.-K. 2019-10-02 doi:10.1101/790139 Cold Spring Harbor Laboratory Press 2019-10-02 <![CDATA[ A physics-based energy function allows the computational redesign of a PDZ domain ]]> https://biorxiv.org/content/10.1101/790667v1?rss=1 nView larger version (26K):norg.highwire.dtl.DTLVardef@145ea28org.highwire.dtl.DTLVardef@10ffa2forg.highwire.dtl.DTLVardef@1f2460eorg.highwire.dtl.DTLVardef@d5691c_HPS_FORMAT_FIGEXP M_FIG Table of Contents GraphicnnC_FIG ]]> Opuu, V. Sun, Y. J. Hou, T. Panel, N. Ichikawa, D. M. Corbi-Verge, C. Kim, P. M. Noyes, M. Fuentes, E. J. Simonson, T. 2019-10-03 doi:10.1101/790667 Cold Spring Harbor Laboratory Press 2019-10-03 <![CDATA[ A topological analysis of difference topology experiments of condensin with Topoisomerases II ]]> https://biorxiv.org/content/10.1101/795898v1?rss=1 Kim, S. Darcy, I. K. 2019-10-07 doi:10.1101/795898 Cold Spring Harbor Laboratory Press 2019-10-07 <![CDATA[ Human iPSC modeling elucidates mutation-specific responses to gene therapy in a genotypically diverse dominant maculopathy ]]> https://biorxiv.org/content/10.1101/796581v1?rss=1 Sinha, D. Steyer, B. G. Shahi, P. K. Mueller, K. Valiauga, R. Edwards, K. L. Bacig, C. Steltzer, S. S. Srinivasan, S. Abdeen, A. Cory, E. Periyasamy, V. Siahpirani, A. F. Stone, E. M. Tucker, B. A. Roy, S. Pattnaik, B. R. Saha, K. Gamm, D. M. 2019-10-08 doi:10.1101/796581 Cold Spring Harbor Laboratory Press 2019-10-08 <![CDATA[ Transcriptomic Profile Analysis of Brain Inferior Colliculus Following Acute Hydrogen Sulfide Exposure ]]> https://biorxiv.org/content/10.1101/816710v1?rss=1 1.5). Hydrogen sulfide exposure modulated multiple biological pathways including unfolded protein response, neurotransmitters, oxidative stress, hypoxia, calcium signaling, and inflammatory response in the IC. Hydrogen sulfide exposure activated PI3K/Akt and MAPK signaling pathways. Pro-inflammatory cytokines were shown to be potential initiators of the modulated signaling pathways following H2S exposure. Furthermore, microglia were shown to release IL-18 and astrocytes released both IL-1{beta} and IL-18 in response to H2S. This transcriptomic analysis data revealed complex signaling pathways involved in H2S-induced neurotoxicity and may provide important associated mechanistic insights. HighlightsO_LITranscriptomic profiling analyses following acute exposure to H2S were performed C_LIO_LIMultiple signaling pathways were dysregulated following H2S exposure C_LIO_LIPI3K/Akt and MAPK signaling pathways were activated after H2S exposure C_LIO_LIMRI scan analysis revealed lesions in the IC and TH following H2S exposure C_LIO_LIAcute H2S exposure induced a neuroinflammatory response C_LI ]]> Kim, D.-S. Anantharam, P. Padhi, P. Thedens, D. R. Li, G. Gilbreath, E. Rumbeiha, W. K. 2019-10-24 doi:10.1101/816710 Cold Spring Harbor Laboratory Press 2019-10-24 <![CDATA[ External and Internal Signal-to-noise Ratios Alter Timing and Location of Cortical Activities During Speech-in-noise Perception ]]> https://biorxiv.org/content/10.1101/817460v1?rss=1 Kim, S. Schwalje, A. T. Liu, A. S. Gander, P. E. McMurray, B. Griffiths, T. D. Choi, I. 2019-10-28 doi:10.1101/817460 Cold Spring Harbor Laboratory Press 2019-10-28 <![CDATA[ Prostaglandins regulate invasive, collective border cell migration ]]> https://biorxiv.org/content/10.1101/821686v1?rss=1 Fox, E. F. Lamb, M. C. Melletine, S. Q. Tootle, T. L. 2019-10-28 doi:10.1101/821686 Cold Spring Harbor Laboratory Press 2019-10-28 <![CDATA[ NADPH and glutathione redox link TCA cycle activity to endoplasmic reticulum stress ]]> https://biorxiv.org/content/10.1101/822775v1?rss=1 Gansemer, E. R. McCommis, K. S. Martino, M. King-McAlpin, A. Q. Potthoff, M. J. Finck, B. N. Taylor, E. B. Rutkowski, D. T. 2019-10-29 doi:10.1101/822775 Cold Spring Harbor Laboratory Press 2019-10-29 <![CDATA[ Presynaptic development is controlled by the core active zone proteins CAST/ELKS ]]> https://biorxiv.org/content/10.1101/823542v1?rss=1 Radulovic, T. Dong, W. Goral, R. O. Thomas, C. I. Veeraraghavan, P. Montesinos, M. S. Guerrero-Given, D. Goff, K. Luebbert, M. Kamasawa, N. Ohtuska, T. Young, S. M. 2019-10-30 doi:10.1101/823542 Cold Spring Harbor Laboratory Press 2019-10-30 <![CDATA[ Cortical functional connectivity indexes arousal state during sleep and anesthesia ]]> https://biorxiv.org/content/10.1101/823963v1?rss=1 Banks, M. I. Krause, B. M. Endemann, C. M. Campbell, D. I. Kovach, C. K. Dyken, M. E. Kawasaki, H. Nourski, K. V. 2019-10-30 doi:10.1101/823963 Cold Spring Harbor Laboratory Press 2019-10-30 <![CDATA[ Mapping the Immune Landscape of Clear Cell Renal Cell Carcinoma by Single-Cell RNA-seq ]]> https://biorxiv.org/content/10.1101/824482v1?rss=1 Vishwakarma, A. Borcherding, N. Chimenti, M. S. Vishwakarma, P. Nepple, K. Salem, A. Jenkins, R. W. Zhang, W. Zakharia, Y. 2019-10-31 doi:10.1101/824482 Cold Spring Harbor Laboratory Press 2019-10-31 <![CDATA[ Transcriptome profiles in brains of mice heterozygous for a DYT1 dystonia-associated mutation in the endogenous Tor1a gene ]]> https://biorxiv.org/content/10.1101/825505v1?rss=1 Mitchell, S. B. Chimenti, M. S. Kawano, H. Yuen, T. M. T. Sjurson, A. E. Iwabuchi, S. Knudtson, K. L. Bair, T. B. Kolbe, D. Harata, N. C. 2019-10-31 doi:10.1101/825505 Cold Spring Harbor Laboratory Press 2019-10-31 <![CDATA[ Removal of high frequency contamination from motion estimates in single-band fMRI saves data without biasing functional connectivity ]]> https://biorxiv.org/content/10.1101/837161v1?rss=1 0.1 Hz, here referred to as HF-motion), primarily in the phase-encoding direction. This periodicity can sometimes be obscured in standard single-band fMRI (TR 2.0 - 2.5 s.) due to aliasing. Here we examined (1) how prevalent HF-motion effects are in seven single-band datasets with TR from 2.0 - 2.5 s and (2) how HF-motion affects functional connectivity. We demonstrate that HF-motion is relatively trait-like and more common in older adults, those with higher body mass index, and those with lower cardiorespiratory fitness. We propose a low-pass filtering approach to remove the contamination of high frequency effects from motion summary measures, such as framewise displacement (FD). We demonstrate that in most datasets this filtering approach saves a substantial amount of data from FD-based frame censoring, while at the same time reducing motion biases in functional connectivity measures. These findings suggest that filtering motion parameters is an effective way to improve the fidelity of head motion estimates, even in single band datasets. Particularly large data savings may accrue in datasets acquired in older and less fit participants. Highlights- Single-band fMRI motion traces show factitious high-frequency content (HF-motion) - The magnitude of HF-motion relates to age and other demographic factors - HF-motion elevates framewise displacement (FD) and causes data loss - Substantial fMRI data can be recovered from censoring by filtering motion traces - Filtering motion traces reduces motion artifacts in functional connectivity ]]> Gratton, C. Coalson, R. S. Dworetsky, A. Adeyemo, B. Laumann, T. O. Wig, G. S. Kong, T. S. Gratton, G. Fabiani, M. Barch, D. M. Tranel, D. Miranda-Dominguez, O. Fair, D. A. Dosenbach, N. U. F. Snyder, A. Z. Perlmutter, J. S. Petersen, S. E. Campbell, M. C. 2019-11-09 doi:10.1101/837161 Cold Spring Harbor Laboratory Press 2019-11-09 <![CDATA[ Protein prenylation and Hsp40 in thermotolerance of Plasmodium falciparum malaria parasites ]]> https://biorxiv.org/content/10.1101/842468v1?rss=1 Mathews, E. S. Jezewski, A. J. Odom John, A. R. 2019-11-14 doi:10.1101/842468 Cold Spring Harbor Laboratory Press 2019-11-14 <![CDATA[ Derivatives of the antimalarial drug mefloquine are broad spectrum antifungal molecules with activity against drug-resistant clinical isolates ]]> https://biorxiv.org/content/10.1101/851816v1?rss=1 Montoya, M. C. Beattie, S. R. Alden, K. M. Krysan, D. J. 2019-11-22 doi:10.1101/851816 Cold Spring Harbor Laboratory Press 2019-11-22 <![CDATA[ Calcium-induced calcium release in noradrenergic neurons of the locus coeruleus ]]> https://biorxiv.org/content/10.1101/853283v1?rss=1 Kawano, H. Mitchell, S. B. Koh, J.-Y. Goodman, K. M. Harata, N. C. 2019-11-23 doi:10.1101/853283 Cold Spring Harbor Laboratory Press 2019-11-23 <![CDATA[ The Molecular Basis of Specific DNA Binding by the BRG1 AT-hook and Bromodomain ]]> https://biorxiv.org/content/10.1101/854000v1?rss=1 20% of human tumors. The mechanism by which BAF properly navigates chromatin is not fully understood, but is thought to involve a multivalent network of histone and DNA contacts. We previously identified a composite domain in the BRG1 ATPase subunit that is capable of associating with both histones and DNA in a multivalent manner. Mapping the DNA binding pocket revealed that it contains several cancer mutations. Here, we utilize SELEX-seq to identify the DNA specificity of this composite domain and NMR spectroscopy and molecular modelling to determine the structural basis of DNA binding. Finally, we demonstrate that cancer mutations in this domain alter the mode of DNA association. ]]> Sanchez, J. C. Zhang, L. Evoli, S. Schnicker, N. J. Nunez-Hernandez, M. Yu, L. Wereszczynski, J. Pufall, M. A. Musselman, C. A. 2019-11-25 doi:10.1101/854000 Cold Spring Harbor Laboratory Press 2019-11-25 <![CDATA[ Dose and duration of IFNγ pre-licensing interact with donor characteristics to influence the expression and function of IDO in MSCs ]]> https://biorxiv.org/content/10.1101/855270v1?rss=1 Boyt, D. Boland, L. K. Burand, A. J. Brown, A. J. Ankrum, J. A. 2019-11-26 doi:10.1101/855270 Cold Spring Harbor Laboratory Press 2019-11-26 <![CDATA[ 3dSpAn: an interactive software for 3D segmentation and analysis of dendritic spines ]]> https://biorxiv.org/content/10.1101/864587v1?rss=1 Basu, S. Das, N. Baczynska, E. Bijata, M. Zeug, A. Plewczynski, D. Saha, P. K. Ponimaskin, E. Wlodarczyk, J. 2019-12-05 doi:10.1101/864587 Cold Spring Harbor Laboratory Press 2019-12-05 <![CDATA[ Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures ]]> https://biorxiv.org/content/10.1101/865386v1?rss=1 de March, C. A. Titlow, W. B. Sengoku, T. Breheny, P. Matsunami, H. McClintock, T. S. 2019-12-04 doi:10.1101/865386 Cold Spring Harbor Laboratory Press 2019-12-04 <![CDATA[ Systemic Treatment with Nicotinamide Riboside is Protective in Three Mouse Models of Retinal Degeneration ]]> https://biorxiv.org/content/10.1101/866798v1?rss=1 Zhang, X. Henneman, N. F. Girardot, P. E. Sellers, J. T. Chrenek, M. A. Li, Y. Wang, J. Brenner, C. M. Nickerson, J. M. Boatright, J. 2019-12-06 doi:10.1101/866798 Cold Spring Harbor Laboratory Press 2019-12-06 <![CDATA[ Evolutionarily ancient BAH-PHD protein mediates Polycomb silencing ]]> https://biorxiv.org/content/10.1101/868117v1?rss=1 Wiles, E. T. McNaught, K. J. De Silva, S. M. Kaur, G. Selker, J. M. Ormsby, T. Aravind, L. Musselman, C. A. Selker, E. U. 2019-12-06 doi:10.1101/868117 Cold Spring Harbor Laboratory Press 2019-12-06 <![CDATA[ Pragmatic Language Processing in the Adolescent Brain ]]> https://biorxiv.org/content/10.1101/871343v1?rss=1 Asaridou, S. S. Demir-Lira, E. Udden, J. S. Goldin-Meadow, S. Small, S. L. 2019-12-11 doi:10.1101/871343 Cold Spring Harbor Laboratory Press 2019-12-11 <![CDATA[ Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56 delta holoenzyme ]]> https://biorxiv.org/content/10.1101/2023.03.09.530109v1?rss=1 Wu, C.-G. Balakrishnan, V. K. Parihar, P. S. Konovolov, K. Chen, Y.-C. Merrill, R. A. Wei, H. Carragher, B. Sundaresan, R. Cui, Q. Wadzinski, B. E. Swingle, M. R. Musiyenko, A. Honkanen, R. Suzuki, A. Strack, S. Huang, X. Xing, Y. 2023-03-09 doi:10.1101/2023.03.09.530109 Cold Spring Harbor Laboratory Press 2023-03-09 <![CDATA[ The Voltage-gated sodium channel in Drosophila, Para, localizes to dendrites as well as axons in mechanosensitive chordotonal neurons ]]> https://biorxiv.org/content/10.1101/2023.03.07.531558v1?rss=1 Ravenscroft, T. A. Jacobs, A. Gu, M. Eberl, D. F. Bellen, H. J. 2023-03-10 doi:10.1101/2023.03.07.531558 Cold Spring Harbor Laboratory Press 2023-03-10 <![CDATA[ ATF4 Expression in Thermogenic Adipocytes is Required for Cold-Induced Thermogenesis in Mice via FGF21-Independent Mechanisms ]]> https://biorxiv.org/content/10.1101/2023.03.09.531964v1?rss=1 View larger version (45K): org.highwire.dtl.DTLVardef@1d2c3fdorg.highwire.dtl.DTLVardef@414f5forg.highwire.dtl.DTLVardef@1c1fa9eorg.highwire.dtl.DTLVardef@2cc815_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Bjorkman, S. H. Marti, A. Jena, J. Pena, L. M. G. Weatherford, E. T. Kato, K. Koneru, J. Chen, J. H. Sood, A. Potthoff, M. J. Adams, C. M. Abel, E. D. Pereira, R. O. 2023-03-10 doi:10.1101/2023.03.09.531964 Cold Spring Harbor Laboratory Press 2023-03-10 <![CDATA[ A single C-terminal residue controls SARS-CoV-2 spike trafficking and virion assembly ]]> https://biorxiv.org/content/10.1101/2023.03.09.531992v1?rss=1 Dey, D. Qing, E. He, Y. Chen, Y. Jennings, B. Cohn, W. Singh, S. Gakhar, L. Schnicker, N. J. Pierce, B. G. Whitelegge, J. P. Doray, B. Orban, J. P. Gallagher, T. Hasan, S. S. 2023-03-10 doi:10.1101/2023.03.09.531992 Cold Spring Harbor Laboratory Press 2023-03-10 <![CDATA[ Structural context of homomeric interactions in the Ig domain of the MPZ (P0) myelin adhesion protein and relation to Charcot-Marie-Tooth disease phenotype variants ]]> https://biorxiv.org/content/10.1101/2023.03.18.533291v1?rss=1 Ptak, C. P. Peterson, T. A. Hopkins, J. B. Ahern, C. A. Shy, M. E. Piper, R. C. 2023-03-19 doi:10.1101/2023.03.18.533291 Cold Spring Harbor Laboratory Press 2023-03-19 <![CDATA[ CHOP drives cells to mutually exclusive cell fates--death and proliferation--during ER stress ]]> https://biorxiv.org/content/10.1101/2023.03.19.533325v1?rss=1 Liu, K. Zhao, C. Rutkowski, D. T. 2023-03-21 doi:10.1101/2023.03.19.533325 Cold Spring Harbor Laboratory Press 2023-03-21 <![CDATA[ DISTINCT ROLES OF VIRAL US3 AND UL13 PROTEIN KINASES IN HERPES VIRUS SIMPLEX TYPE 1 (HSV-1) NUCLEAR EGRESS ]]> https://biorxiv.org/content/10.1101/2023.03.20.533584v1?rss=1 Masoud Bahnamiri, M. Roller, R. J. 2023-03-21 doi:10.1101/2023.03.20.533584 Cold Spring Harbor Laboratory Press 2023-03-21 <![CDATA[ Partial or complete loss of norepinephrine differentially alters contextual fear and catecholamine release dynamics in hippocampal CA1 ]]> https://biorxiv.org/content/10.1101/2023.03.26.534277v1?rss=1 Wilson, L. R. Plummer, N. W. Evsyukova, I. Y. Patino, D. Stewart, C. L. Smith, K. G. Fry, S. A. Deal, A. L. Kilonzo, V. W. Sciolino, N. R. Cushman, J. D. jensen, p. 2023-03-27 doi:10.1101/2023.03.26.534277 Cold Spring Harbor Laboratory Press 2023-03-27 <![CDATA[ DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation ]]> https://biorxiv.org/content/10.1101/2023.04.03.535399v1?rss=1 Mullen, N. J. Shukla, S. K. Thakur, R. Kollala, S. S. Wang, D. Chaika, N. LaBreck, D. A. Mallareddy, J. R. Price, D. Natarajan, A. Mehla, K. Sykes, D. B. Hollingsworth, M. A. Singh, P. K. 2023-04-05 doi:10.1101/2023.04.03.535399 Cold Spring Harbor Laboratory Press 2023-04-05 <![CDATA[ A new tractable method for generating Human Alveolar Macrophage Like cells in vitro to study lung inflammatory processes and diseases ]]> https://biorxiv.org/content/10.1101/2023.04.05.535806v1?rss=1 Pahari, S. Arnett, E. Simper, J. Azad, A. Guerrero-Arguero, I. Ye, C. Zhang, H. Cai, H. Wang, Y. Lai, Z. Jarvis, N. Lumbreras, M. Maselli-Caceres, D. J. Peters, J. I. Torrelles, J. B. Mart ínez-Sobrido, L. Schlesinger, L. S. 2023-04-08 doi:10.1101/2023.04.05.535806 Cold Spring Harbor Laboratory Press 2023-04-08 <![CDATA[ Inhibition of serotonin biosynthesis in neuroendocrine neoplasm suppressestumor growth in vivo ]]> https://biorxiv.org/content/10.1101/2023.04.07.536013v1?rss=1 Tow, D. H. Tran, C. G. Borbon, L. C. Ridder, M. Li, G. Kaemmer, C. A. Abusada, E. Mahalingam, A. H. Sadanandam, A. Chandrasekharan, C. Dillon, J. Spitz, D. R. Quelle, D. E. Chan, C. H. F. Bellizzi, A. M. Howe, J. R. Ear, P. H. 2023-04-08 doi:10.1101/2023.04.07.536013 Cold Spring Harbor Laboratory Press 2023-04-08 <![CDATA[ Acid enhances salt taste by activating the epithelial sodium channel ]]> https://biorxiv.org/content/10.1101/2023.04.14.536795v1?rss=1 Collier, D. M. Peterson, Z. J. Ryan, A. J. Williford, N. N. Benson, C. J. Snyder, P. M. 2023-04-16 doi:10.1101/2023.04.14.536795 Cold Spring Harbor Laboratory Press 2023-04-16 <![CDATA[ RGS6 mediates exercise-induced recovery of hippocampal neurogenesis, learning, and memory in an Alzheimer's mouse model ]]> https://biorxiv.org/content/10.1101/2023.04.17.537272v1?rss=1 Spicer, M. M. Yang, J. Fu, D. A. DeVore, A. N. Lauffer, M. Sayar-Atasoy, N. Atasoy, D. M. Fisher, R. A. 2023-04-18 doi:10.1101/2023.04.17.537272 Cold Spring Harbor Laboratory Press 2023-04-18 <![CDATA[ spotter: A single-nucleotide resolution stochastic simulation model of supercoiling-mediated transcription and translation in prokaryotes ]]> https://biorxiv.org/content/10.1101/2023.04.21.537861v1?rss=1 Hacker, W. C. Elcock, A. H. 2023-04-22 doi:10.1101/2023.04.21.537861 Cold Spring Harbor Laboratory Press 2023-04-22 <![CDATA[ An Orientationally Averaged Version of the Rotne-Prager-Yamakawa Tensor Provides A Fast But Still Accurate Treatment Of Hydrodynamic Interactions In Brownian Dynamics Simulations Of Biological Macromolecules ]]> https://biorxiv.org/content/10.1101/2023.04.21.537865v1?rss=1 Tworek, J. W. Elcock, A. H. 2023-04-25 doi:10.1101/2023.04.21.537865 Cold Spring Harbor Laboratory Press 2023-04-25 <![CDATA[ Distinct blood CD3+ CD14+ T Cell-Monocyte complexes harbor HIV and are dynamic, glucose-dependent, and increased in individuals with glucose intolerance ]]> https://biorxiv.org/content/10.1101/2023.04.24.538020v1?rss=1 View larger version (37K): org.highwire.dtl.DTLVardef@fdc324org.highwire.dtl.DTLVardef@168fc4org.highwire.dtl.DTLVardef@138a9a0org.highwire.dtl.DTLVardef@1087108_HPS_FORMAT_FIGEXP M_FIG C_FIG HighlightsO_LICirculating CD3+ CD14+ T cell-monocyte complexes are higher in individuals with diabetes. C_LIO_LICD3+ CD14+ T cell-monocytes complexes comprise a heterogenous group of functional and dynamic cell-cell interactions. C_LIO_LIThe proportion of CD3+ CD14+ T cell-monocyte complexes is positively associated with fasting blood glucose and negatively with plasma IL-10 levels and CD4+ T regulatory cells. C_LIO_LICD3+ CD14+ T cell-monocyte complexes are metabolically flexible and can utilize both glycolysis and oxidative phosphorylation for their energy requirements. C_LIO_LIIn persons with treated HIV, CD3+ CD14+ T cell-monocytes have more detectable HIV DNA than circulating CD4+ T cells alone. C_LI ]]> Wanjalla, C. N. Simmons, J. Oakes, J. Zhang, X. Nochowivz, C. Priest, S. Bailin, S. S. Watten, C. M. Mashayekhi, M. Beasley, H. K. Wang, J. Meenderink, L. M. Sheng, Q. Stolze, J. Gangula, R. Chopra, A. Gabriel, C. L. Temu, T. Pakala, S. Wilfong, E. M. Gianella, S. Phillips, E. J. Harrison, D. G. Hinton, A. Kalams, S. A. Mallal, S. A. Koethe, J. R. 2023-04-26 doi:10.1101/2023.04.24.538020 Cold Spring Harbor Laboratory Press 2023-04-26 <![CDATA[ Sex similarities and dopaminergic differences in interval timing ]]> https://biorxiv.org/content/10.1101/2023.05.05.539584v1?rss=1 Stutt, H. R. Weber, M. A. Cole, R. C. Bova, A. S. Ding, X. McMurrin, M. S. Narayanan, N. 2023-05-05 doi:10.1101/2023.05.05.539584 Cold Spring Harbor Laboratory Press 2023-05-05 <![CDATA[ Auranofin Inhibition of Thioredoxin Reductase in a Preclinical Model of Small Cell Lung Cancer ]]> https://biorxiv.org/content/10.1101/2023.05.07.539772v1?rss=1 Johnson, S. S. Liu, D. Ewald, J. T. Robles-Planells, C. Bayanbold, K. Wels, B. R. Solst, S. R. ODorisio, M. S. Allen, B. G. Menda, Y. Spitz, D. R. Fath, M. 2023-05-09 doi:10.1101/2023.05.07.539772 Cold Spring Harbor Laboratory Press 2023-05-09 <![CDATA[ Single-molecule analysis of the improved variants of the G-quadruplex recognition protein G4P ]]> https://biorxiv.org/content/10.1101/2023.05.08.539902v1?rss=1 Gaur, P. Bain, F. E. Honda, M. Granger, S. L. Spies, M. 2023-05-09 doi:10.1101/2023.05.08.539902 Cold Spring Harbor Laboratory Press 2023-05-09 <![CDATA[ Temporally organized representations of reward and risk in the human brain ]]> https://biorxiv.org/content/10.1101/2023.05.09.539916v1?rss=1 Man, V. Cockburn, J. Flouty, O. Gander, P. E. Sawada, M. Kovach, C. K. Kawasaki, H. Oya, H. Howard, M. A. O'Doherty, J. P. 2023-05-09 doi:10.1101/2023.05.09.539916 Cold Spring Harbor Laboratory Press 2023-05-09 <![CDATA[ De novo distillation of thermodynamic affinity from deep learning regulatory sequence models of in vivo protein-DNA binding ]]> https://biorxiv.org/content/10.1101/2023.05.11.540401v1?rss=1 Alexandari, A. M. Horton, C. A. Shrikumar, A. Shah, N. Li, E. Weilert, M. Pufall, M. A. Zeitlinger, J. Fordyce, P. M. Kundaje, A. 2023-05-11 doi:10.1101/2023.05.11.540401 Cold Spring Harbor Laboratory Press 2023-05-11 <![CDATA[ Human hnRNPA1 reorganizes telomere-bound Replication Protein A ]]> https://biorxiv.org/content/10.1101/2023.05.09.540056v1?rss=1 Granger, S. L. Sharma, R. Kaushik, V. Razzaghi, M. Honda, M. Bhat, D. S. Wlodarski, M. Antony, E. Spies, M. 2023-05-12 doi:10.1101/2023.05.09.540056 Cold Spring Harbor Laboratory Press 2023-05-12 <![CDATA[ Defining Mitochondrial Cristae Morphology Changes Induced by Aging in Brown Adipose Tissue ]]> https://biorxiv.org/content/10.1101/2023.05.12.540609v1?rss=1 View larger version (27K): org.highwire.dtl.DTLVardef@96099borg.highwire.dtl.DTLVardef@50b4f4org.highwire.dtl.DTLVardef@983092org.highwire.dtl.DTLVardef@19ceb9b_HPS_FORMAT_FIGEXP M_FIG O_FLOATNOGraphical Abstract:C_FLOATNO Overview of serial block facing-scanning electron microscopy (SBF-SEM) workflow, data segmentation, and 3D analysis of mitochondria using Amira software for murine interscapular BAT. C_FIG ]]> Crabtree, A. Neikirk, K. Marshall, A. Vang, L. Stephens, D. Shao, B. Garza-Lopez, E. Lam, J. Rodriguez, B. Mungai, M. Stanley, J. Dean, D. Gaddy, J. Scudese, E. Sweetwyne, M. Davis, J. Zaganjor, E. Murray, S. Katti, P. Damo, S. Vue, Z. Hinton, A. 2023-05-14 doi:10.1101/2023.05.12.540609 Cold Spring Harbor Laboratory Press 2023-05-14 <![CDATA[ Trans-complementation by the RecB nuclease domain of RecBCD enzyme reveals new insight into RecA loading upon χ recognition ]]> https://biorxiv.org/content/10.1101/2023.05.14.540676v1?rss=1 Pavankumar, T. L. Wong, C. J. Wong, Y. K. Spies, M. Kowalczykowski, S. C. 2023-05-14 doi:10.1101/2023.05.14.540676 Cold Spring Harbor Laboratory Press 2023-05-14 <![CDATA[ Transcriptomic Evaluation of Stress Vulnerability Network using Single Cell RNA-Seq in mouse Prefrontal Cortex ]]> https://biorxiv.org/content/10.1101/2023.05.14.540705v1?rss=1 View larger version (38K): org.highwire.dtl.DTLVardef@1ebe036org.highwire.dtl.DTLVardef@cd2131org.highwire.dtl.DTLVardef@13e3519org.highwire.dtl.DTLVardef@1100e62_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Hing, B. Mitchell, S. B. Eberle, M. Filali, Y. Matkovich, M. Kasturirangan, M. Hultman, I. Wyche, W. Jimenez, A. Velamuri, R. Johnson, M. Srivastava, S. Hultman, R. 2023-05-14 doi:10.1101/2023.05.14.540705 Cold Spring Harbor Laboratory Press 2023-05-14 <![CDATA[ Rapid, efficient auxin-inducible protein degradation in Candida pathogens ]]> https://biorxiv.org/content/10.1101/2023.05.17.541235v1?rss=1 95% degradation of target proteins within minutes. In the case of AID2, maximal degradation was achieved at low nanomolar concentrations of the synthetic auxin analog 5-adamantyl-indole-3-acetic acid (5-Ad-IAA). Auxin-induced target degradation successfully phenocopied gene deletions in both species. The system should be readily adaptable to other fungal species and to clinical pathogen strains. Our results define the AID system as a powerful and convenient functional genomics tool for protein characterization in fungal pathogens. ]]> Milholland, K. L. Gregor, J. B. Hoda, S. Piriz-Antunez, S. Duenas-Santero, E. Vu, B. G. Patel, K. P. Moye-Rowley, W. S. Vazguez de Aldana, C. R. Correa-Bordes, J. Briggs, S. D. Hall, M. C. 2023-05-18 doi:10.1101/2023.05.17.541235 Cold Spring Harbor Laboratory Press 2023-05-18 <![CDATA[ Exercise modulates human hippocampal-cortical ripple dynamics ]]> https://biorxiv.org/content/10.1101/2023.05.19.541461v1?rss=1 Cardenas, A. R. Ramirez-Villegas, J. F. Kovach, C. K. Gander, P. E. Cole, R. C. Grossbach, A. J. Kawasaki, H. Greenlee, J. D. Howard, M. A. Nourski, K. V. Banks, M. I. Voss, M. W. 2023-05-22 doi:10.1101/2023.05.19.541461 Cold Spring Harbor Laboratory Press 2023-05-22 <![CDATA[ Optimizing In Situ Proximity Ligation Assays for Mitochondria, ER, or MERC Markers in Skeletal Muscle Tissue and Cells ]]> https://biorxiv.org/content/10.1101/2023.05.20.541599v1?rss=1 View larger version (33K): org.highwire.dtl.DTLVardef@1021ce7org.highwire.dtl.DTLVardef@1b78f8borg.highwire.dtl.DTLVardef@31030corg.highwire.dtl.DTLVardef@1bf0afa_HPS_FORMAT_FIGEXP M_FIG C_FIG O_TBL View this table: org.highwire.dtl.DTLVardef@169ba8corg.highwire.dtl.DTLVardef@566b30org.highwire.dtl.DTLVardef@197330dorg.highwire.dtl.DTLVardef@198ca7borg.highwire.dtl.DTLVardef@158b80_HPS_FORMAT_FIGEXP M_TBL C_TBL ]]> Stephens, D. C. Crabtree, A. Beasley, H. K. Garza-Lopez, E. Neikirk, K. Mungai, M. Vang, L. Vue, Z. Vue, N. Marshall, A. G. Turner, K. Shao, J.-q. Murray, S. A. Gaddy, J. A. Wanjalla, C. Davis, J. Damo, S. M. Hinton, A. 2023-05-22 doi:10.1101/2023.05.20.541599 Cold Spring Harbor Laboratory Press 2023-05-22 <![CDATA[ Components of Isolated Skeletal Muscle Differentiated Through Antibody Validation ]]> https://biorxiv.org/content/10.1101/2023.05.20.541600v1?rss=1 View larger version (45K): org.highwire.dtl.DTLVardef@165b34dorg.highwire.dtl.DTLVardef@1de9976org.highwire.dtl.DTLVardef@12d3cfeorg.highwire.dtl.DTLVardef@ff660c_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Stephens, D. C. Mungai, M. Crabtree, A. Beasley, H. K. Garza-Lopez, E. Vang, L. Neikirk, K. Vue, Z. Vue, N. Marshall, A. G. Turner, K. Shao, J.-q. Sarker, B. Murray, S. A. Gaddy, J. A. Davis, J. Damo, S. M. Hinton, A. 2023-05-22 doi:10.1101/2023.05.20.541600 Cold Spring Harbor Laboratory Press 2023-05-22 <![CDATA[ Creating Optimal Conditions for OPA1 isoforms by Western Blot in Muscle Tissue ]]> https://biorxiv.org/content/10.1101/2023.05.20.541601v1?rss=1 View larger version (28K): org.highwire.dtl.DTLVardef@1dc254dorg.highwire.dtl.DTLVardef@150d3eorg.highwire.dtl.DTLVardef@186ed2org.highwire.dtl.DTLVardef@13cc3a_HPS_FORMAT_FIGEXP M_FIG C_FIG O_TBL View this table: org.highwire.dtl.DTLVardef@1c518ceorg.highwire.dtl.DTLVardef@df826borg.highwire.dtl.DTLVardef@1eb5bf8org.highwire.dtl.DTLVardef@e324e6org.highwire.dtl.DTLVardef@8baedc_HPS_FORMAT_FIGEXP M_TBL C_TBL Method SummarySamples for western blot analysis are isolated from lysed cells, loaded onto a gel, and ran using optimized conditions to better isolate OPA1 isoforms. Samples are transferred to a membrane for incubation and protein detection using OPA1 antibodies. ]]> Stephens, D. C. Crabtree, A. Beasley, H. K. Garza-Lopez, E. Mungai, M. Neikirk, K. Vang, L. Vue, Z. Vue, N. Marshall, A. G. Turner, K. Shao, J.-q. Murray, S. A. Gaddy, J. A. Wanjalla, C. Davis, J. Damo, S. M. Hinton, A. 2023-05-22 doi:10.1101/2023.05.20.541601 Cold Spring Harbor Laboratory Press 2023-05-22 <![CDATA[ Ablation of Sam50 is associated with fragmentation and alterations in metabolism in human myotubes ]]> https://biorxiv.org/content/10.1101/2023.05.20.541602v1?rss=1 Vue, Z. Vang, C. Neikirk, K. Garza-Lopez, E. Shao, J.-q. Mungai, M. Vang, L. Beasley, H. K. Marshall, A. G. Crabtree, A. Stephens, D. C. McReynolds, M. Murray, S. A. Katti, P. Gaddy, J. A. Damo, S. M. Hinton, A. 2023-05-22 doi:10.1101/2023.05.20.541602 Cold Spring Harbor Laboratory Press 2023-05-22 <![CDATA[ Reinforcement-based option competition in human dorsal stream during exploration/exploitation of a continuous space ]]> https://biorxiv.org/content/10.1101/2023.05.22.541828v1?rss=1 View larger version (74K): org.highwire.dtl.DTLVardef@155b3c8org.highwire.dtl.DTLVardef@18e28c5org.highwire.dtl.DTLVardef@16d7c1org.highwire.dtl.DTLVardef@1aed684_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Hallquist, M. Hwang, K. Luna, B. Dombrovski, A. Y. 2023-05-23 doi:10.1101/2023.05.22.541828 Cold Spring Harbor Laboratory Press 2023-05-23 <![CDATA[ A bioinformatics tool for identifying intratumoral microbes from the ORIEN dataset ]]> https://biorxiv.org/content/10.1101/2023.05.24.541982v1?rss=1 Wang, C. Ma, A. McNutt, M. E. Hoyd, R. Wheeler, C. E. Robinson, L. A. Chan, C. H. F. Zakharia, Y. Dodd, R. D. Ulrich, C. M. Hardikar, S. Churchman, M. L. Tarhini, A. A. Singer, E. A. Ikeguchi, A. P. McCarter, M. D. Denko, N. Tinoco, G. Husain, M. Jin, N. Osman, A. E. G. Eljilany, I. Tan, A. C. Coleman,, S. S. Denko, L. Riedlinger, G. Schneider, B. P. Spakowicz, D. Ma, Q. 2023-05-24 doi:10.1101/2023.05.24.541982 Cold Spring Harbor Laboratory Press 2023-05-24 <![CDATA[ The tumor microbiome as a predictor of outcomes in patients with metastatic melanoma treated with immune checkpoint inhibitors ]]> https://biorxiv.org/content/10.1101/2023.05.24.542123v1?rss=1 24 months following the initiation of ICI treatment. Exogenous taxa were identified in the tumor RNA-seq, including bacteria, fungi, and viruses. We found differences in gene expression and microbe abundances in immunotherapy responsive versus non-responsive tumors. Responders showed significant enrichment of several microbes including Fusobacterium nucleatum, and non-responders showed enrichment of fungi, as well as several bacteria. These microbes correlated with immune-related gene expression signatures. Finally, we found that models for predicting prolonged survival with immunotherapy using both microbe abundances and gene expression outperformed models using either dataset alone. Our findings warrant further investigation and potentially support therapeutic strategies to modify the tumor microbiome in order to improve treatment outcomes with ICIs. SignificanceWe analyzed the tumor microbiome and interactions with genes and pathways in metastatic melanoma treated with immunotherapy, and identified several microbes associated with immunotherapy response and immune-related gene expression signatures. Machine learning models that combined microbe abundances and gene expression outperformed models using either dataset alone in predicting immunotherapy responses. ]]> Wheeler, C. E. Coleman,, S. S. Hoyd, R. Denko, L. Chan, C. H. F. Churchman, M. L. Denko, N. Dodd, R. D. Eljilany, I. Hardikar, S. Husain, M. Ikeguchi, A. P. Jin, N. Ma, Q. McCarter, M. D. Osman, A. E. G. Robinson, L. A. Singer, E. A. Tinoco, G. Ulrich, C. M. Zakharia, Y. Spakowicz, D. Tarhini, A. A. Tan, A. C. 2023-05-25 doi:10.1101/2023.05.24.542123 Cold Spring Harbor Laboratory Press 2023-05-25 <![CDATA[ Mice expressing A53T / A30P mutant alpha-synuclein in dopamine neurons do not display behavioral deficits ]]> https://biorxiv.org/content/10.1101/2023.05.25.542172v1?rss=1 Keomanivong, C. Schamp, J. Tabakovic, E. Thangavel, R. Aldridge, G. Pieper, A. Narayanan, N. 2023-05-25 doi:10.1101/2023.05.25.542172 Cold Spring Harbor Laboratory Press 2023-05-25 <![CDATA[ Anterior chamber depth in mice is controlled by several quantitative trait loci ]]> https://biorxiv.org/content/10.1101/2023.05.25.542357v1?rss=1 Larson, D. Kimber, A. J. Meyer, K. J. Anderson, M. G. 2023-05-25 doi:10.1101/2023.05.25.542357 Cold Spring Harbor Laboratory Press 2023-05-25 <![CDATA[ Alcohol inhibits sociability via serotonin inputs to the nucleus accumbens ]]> https://biorxiv.org/content/10.1101/2023.05.29.542761v1?rss=1 Wang, R. Khan, K. M. Balasubramanian, N. James, T. Pushpavathi, S. G. Kim, D. Pierson, S. Wu, Q. Niciu, M. J. Hefti, M. M. Marcinkiewcz, C. A. 2023-06-01 doi:10.1101/2023.05.29.542761 Cold Spring Harbor Laboratory Press 2023-06-01 <![CDATA[ Upregulation of the NKG2D ligand ULBP2 by JC polyomavirus infection promotes immune recognition by natural killer cells. ]]> https://biorxiv.org/content/10.1101/2023.05.31.543006v1?rss=1 Jost, S. Ahn, J. Chen, S. Yoder, T. Gikundiro, K. E. Lee, E. Gressens, S. B. Kroll, K. Craemer, M. Kaynor, G. C. Lifton, M. Tan, C. S. 2023-06-02 doi:10.1101/2023.05.31.543006 Cold Spring Harbor Laboratory Press 2023-06-02 <![CDATA[ Pseudomonas aeruginosa senses and responds to epithelial potassium flux via Kdp operon to promote biofilm biogenesis ]]> https://biorxiv.org/content/10.1101/2023.06.05.543669v1?rss=1 Rapsinski, G. J. Hill, M. Yarrington, K. D. Haas, A. L. D'Amico, E. J. Armbruster, C. R. Zemke, A. Limoli, D. Bomberger, J. 2023-06-06 doi:10.1101/2023.06.05.543669 Cold Spring Harbor Laboratory Press 2023-06-06 <![CDATA[ Selective neuroimmune modulation by type I interferon drives neuropathology and neurologic dysfunction following traumatic brain injury ]]> https://biorxiv.org/content/10.1101/2023.06.06.543774v1?rss=1 Todd, B. P. Luo, Z. Gilkes, N. Chimenti, M. S. Peterson, Z. Mix, M. Harty, J. T. Nickl-Jockschat, T. Ferguson, P. J. Bassuk, A. G. Newell, E. A. 2023-06-07 doi:10.1101/2023.06.06.543774 Cold Spring Harbor Laboratory Press 2023-06-07 <![CDATA[ Transcription factor FfmA interacts both physically and genetically with AtrR to properly regulate gene expression in the fungus Aspergillus fumigatus ]]> https://biorxiv.org/content/10.1101/2023.06.06.543935v1?rss=1 Paul, S. Stamnes, M. A. Moye-Rowley, W. S. 2023-06-07 doi:10.1101/2023.06.06.543935 Cold Spring Harbor Laboratory Press 2023-06-07 <![CDATA[ Modeling the 3D structure and conformational dynamics of very large RNAs using coarse-grained molecular simulations ]]> https://biorxiv.org/content/10.1101/2023.06.06.543892v1?rss=1 1000 nucleotides) at a resolution of one "bead" per nucleotide. The method starts with a predicted secondary structure and uses several stages of energy minimization and Brownian dynamics (BD) simulation to build 3D models. A key step in the protocol is the temporary addition of a 4th spatial dimension that allows all predicted helical elements to become disentangled from each other in an effectively automated way. We then use the resulting 3D models as input to Brownian dynamics simulations that include hydrodynamic interactions (HIs) that allow the diffusive properties of the RNA to be modelled as well as enabling its conformational dynamics to be simulated. To validate the dynamics part of the method, we first show that when applied to small RNAs with known 3D structures the BD-HI simulation models accurately reproduce their experimental hydrodynamic radii (Rh). We then apply the modelling and simulation protocol to a variety of RNAs for which experimental Rh values have been reported ranging in size from 85 to 3569 nucleotides. We show that the 3D models, when used in BD-HI simulations, produce hydrodynamic radii that are usually in good agreement with experimental estimates for RNAs that do not contain tertiary contacts that persist even under very low salt conditions. Finally, we show that sampling of the conformational dynamics of large RNAs on timescales of 100 {micro}s is computationally feasible with BD-HI simulations. ]]> Henderson, A. N. McDonnell, R. T. Elcock, A. H. 2023-06-08 doi:10.1101/2023.06.06.543892 Cold Spring Harbor Laboratory Press 2023-06-08 <![CDATA[ Sorafenib inhibits invasion of multicellular organoids that mimic Lymphangioleiomyomatosis nodules. ]]> https://biorxiv.org/content/10.1101/2023.06.12.544372v1?rss=1 Koc-Gunel, S. Gautam, L. K. Calvert, B. A. Murthy, S. Harriott, N. C. Nawroth, J. C. Zhou, B. Krymskaya, V. P. Ryan, A. L. 2023-06-12 doi:10.1101/2023.06.12.544372 Cold Spring Harbor Laboratory Press 2023-06-12 <![CDATA[ Involvement of a serotonin/GLP-1 circuit in adolescent isolation-induced diabetes ]]> https://biorxiv.org/content/10.1101/2023.06.12.544498v1?rss=1 Kolling, L. Khan, K. Balasubramanian, N. Guo, D. F. Rahmouni, K. Marcinkiewcz, C. 2023-06-13 doi:10.1101/2023.06.12.544498 Cold Spring Harbor Laboratory Press 2023-06-13 <![CDATA[ AutoRNC: an automated modeling program for building atomic models of ribosome-nascent chain complexes ]]> https://biorxiv.org/content/10.1101/2023.06.14.544999v1?rss=1 McDonnell, R. T. Elcock, A. H. 2023-06-14 doi:10.1101/2023.06.14.544999 Cold Spring Harbor Laboratory Press 2023-06-14 <![CDATA[ TFAP2 paralogs regulate midfacial development in part through a conserved ALX genetic pathway. ]]> https://biorxiv.org/content/10.1101/2023.06.16.545376v1?rss=1 Nguyen, T. T. Mitchell, J. M. Kiel, M. D. Jones, K. L. Williams, T. J. Nichols, J. T. Van Otterloo, E. 2023-06-16 doi:10.1101/2023.06.16.545376 Cold Spring Harbor Laboratory Press 2023-06-16 <![CDATA[ GENE EXPRESSION WITHIN A HUMAN CHOROIDAL NEOVASCULAR MEMBRANE USING SPATIAL TRANSCRIPTOMICS ]]> https://biorxiv.org/content/10.1101/2023.06.16.544770v1?rss=1 Voigt, A. P. Mullin, N. K. Navratil, E. M. Flamme-Wiese, M. J. Lin, L.-C. Scheetz, T. E. Han, I. C. Stone, E. M. Tucker, B. A. Mullins, R. F. 2023-06-17 doi:10.1101/2023.06.16.544770 Cold Spring Harbor Laboratory Press 2023-06-17 <![CDATA[ Disposition and Toxicity of 2,2',5,5'-Tetrachlorobiphenyl in Female Rats Following Intraperitoneal Exposure ]]> https://biorxiv.org/content/10.1101/2023.06.19.544952v1?rss=1 Bullert, A. Li, X. Zhang, C. Lee, K. Pulliam, C. F. Klingelhutz, A. J. Robertson, L. W. Lehmler, H.-J. 2023-06-20 doi:10.1101/2023.06.19.544952 Cold Spring Harbor Laboratory Press 2023-06-20 <![CDATA[ The great divide: rhamnolipids mediate separation between P. aeruginosa and S. aureus ]]> https://biorxiv.org/content/10.1101/2023.06.23.546300v1?rss=1 Bru, J.-L. Kasallis, S. J. Chang, R. Zhuo, Q. Nguyen, J. Pham, P. Warren, E. Whiteson, K. Hoyland-Kroghsbo, N. M. Limoli, D. H. Siryaporn, A. 2023-06-23 doi:10.1101/2023.06.23.546300 Cold Spring Harbor Laboratory Press 2023-06-23 <![CDATA[ The universal suppressor mutation in the HSV-1 nuclear egress complex restores membrane budding defects by stabilizing the oligomeric lattice ]]> https://biorxiv.org/content/10.1101/2023.06.22.546118v1?rss=1 Draganova, E. B. Wang, H. Wu, M. Liao, S. Vu, A. Gonzalez-Del Pino, G. Zhou, Z. H. Roller, R. J. Heldwein, K. 2023-06-24 doi:10.1101/2023.06.22.546118 Cold Spring Harbor Laboratory Press 2023-06-24 <![CDATA[ Alterations in Cardiovascular and Cerebral Pulse Wave Velocity in 5XFAD Murine Model of Alzheimer's Disease ]]> https://biorxiv.org/content/10.1101/2023.06.22.546154v1?rss=1 Marshall, A. G. Neikirk, K. Barongan, T. Shao, B. Crabtree, A. Stephens, D. C. Vue, Z. Beasley, H. K. Garza-Lopez, E. Scudese, E. Damo, S. M. Gomez, J. A. Taffet, G. Hinton, A. Reddy, A. K. 2023-06-25 doi:10.1101/2023.06.22.546154 Cold Spring Harbor Laboratory Press 2023-06-25 <![CDATA[ Specific prostaglandins are produced in the migratory cells and the surrounding substrate to promote Drosophila border cell migration ]]> https://biorxiv.org/content/10.1101/2023.06.23.546291v1?rss=1 Mellentine, S. Q. Ramsey, A. S. Li, J. Brown, H. N. Tootle, T. 2023-06-26 doi:10.1101/2023.06.23.546291 Cold Spring Harbor Laboratory Press 2023-06-26 <![CDATA[ LRRK2 G2019S promotes the development of colon cancer via modulating intestinal inflammation ]]> https://biorxiv.org/content/10.1101/2023.06.28.546897v1?rss=1 Kang, Z. Wang, Y. Gao, J. Z. Sakaguchi, T. Maretzky, T. Gurung, P. Short, S. Xiong, Y. 2023-06-30 doi:10.1101/2023.06.28.546897 Cold Spring Harbor Laboratory Press 2023-06-30 <![CDATA[ Wound microbiota-mediated correction of matrix metalloproteinase expression promotes re-epithelialization of diabetic wounds ]]> https://biorxiv.org/content/10.1101/2023.06.30.547263v1?rss=1 White, E. K. Uberoi, A. Pan, J. T.-C. Ort, J. T. Campbell, A. E. Murga-Garrido, S. M. Harris, J. C. Bhanap, P. Wei, M. Robles, N. Y. Gardner, S. E. Grice, E. A. 2023-06-30 doi:10.1101/2023.06.30.547263 Cold Spring Harbor Laboratory Press 2023-06-30 <![CDATA[ Loss of NR2E3 disrupts rod photoreceptor cell maturation causing a fate switch late in human retinal development. ]]> https://biorxiv.org/content/10.1101/2023.06.30.547279v1?rss=1 Mullin, N. K. Bohrer, L. R. Voigt, A. P. Wright, A. Lozano, L. P. Mullins, R. F. Stone, E. M. Tucker, B. A. 2023-07-01 doi:10.1101/2023.06.30.547279 Cold Spring Harbor Laboratory Press 2023-07-01 <![CDATA[ Arf GAP containing dAsap regulates NMJ organization and synaptic calcium through Arf6-dependent signaling in Drosophila ]]> https://biorxiv.org/content/10.1101/2023.06.30.547304v1?rss=1 Mallik, B. Kushwaha, S. Bisht, A. MJ, H. Frank, C. A. Kumar, V. 2023-07-02 doi:10.1101/2023.06.30.547304 Cold Spring Harbor Laboratory Press 2023-07-02 <![CDATA[ Beta-subunit-eliminated eHAP expression (BeHAPe) cells reveal new properties of the cardiac voltage-gated sodium channel ]]> https://biorxiv.org/content/10.1101/2023.07.08.548226v1?rss=1 Minard, A. Y. Clark, C. J. Ahern, C. A. Piper, R. C. 2023-07-10 doi:10.1101/2023.07.08.548226 Cold Spring Harbor Laboratory Press 2023-07-10 <![CDATA[ 3-hydroxykynurenine is a ROS-inducing cytotoxic tryptophan metabolite that disrupts the TCA cycle ]]> https://biorxiv.org/content/10.1101/2023.07.10.548411v1?rss=1 Buchanan, J. L. Rauckhorst, A. Taylor, E. B. 2023-07-10 doi:10.1101/2023.07.10.548411 Cold Spring Harbor Laboratory Press 2023-07-10 <![CDATA[ Calcineurin is required for Candida glabrata Pdr1 transcriptional activation ]]> https://biorxiv.org/content/10.1101/2023.07.10.548434v1?rss=1 Vu, B. Simonicova, L. Moye-Rowley, W. S. 2023-07-10 doi:10.1101/2023.07.10.548434 Cold Spring Harbor Laboratory Press 2023-07-10 <![CDATA[ The Integrated Stress Response effector GADD34 is repurposed by neurons to promote stimulus-induced translation ]]> https://biorxiv.org/content/10.1101/2023.07.12.548606v1?rss=1 Oliveira, M. M. Mohamed, M. S. Elder, M. K. Banegas-Morales, K. Mamcarz, M. Lu, E. H. Golhan, E. A. N. Navrange, N. Chatterjee, S. Abel, T. Klann, E. 2023-07-12 doi:10.1101/2023.07.12.548606 Cold Spring Harbor Laboratory Press 2023-07-12 <![CDATA[ Determinants of Astrocytic Pathology in Stem Cell Models of Primary Tauopathies ]]> https://biorxiv.org/content/10.1101/2023.07.18.549558v1?rss=1 Fiock, K. L. Hook, J. Hefti, M. M. 2023-07-19 doi:10.1101/2023.07.18.549558 Cold Spring Harbor Laboratory Press 2023-07-19 <![CDATA[ A Medium Chain Fatty Acid, 6-hydroxyhexanoic acid (6-HHA), Protects Against Obesity and Insulin Resistance ]]> https://biorxiv.org/content/10.1101/2023.07.19.549684v1?rss=1 Sebag, S. S. Qian, Q. Upara, C. Ding, Q. Hong, L. Yang, L. 2023-07-20 doi:10.1101/2023.07.19.549684 Cold Spring Harbor Laboratory Press 2023-07-20 <![CDATA[ Exploring the molecular makeup of support cells in insect camera eyes ]]> https://biorxiv.org/content/10.1101/2023.07.19.549729v1?rss=1 Rathore, S. Stahl, A. Benoit, J. B. Buschbeck, E. K. 2023-07-20 doi:10.1101/2023.07.19.549729 Cold Spring Harbor Laboratory Press 2023-07-20 <![CDATA[ On-Demand Expansion Fluorescence and Photoacoustic Microscopy (ExFLPAM) ]]> https://biorxiv.org/content/10.1101/2023.07.19.549787v1?rss=1 Mu, X. Ma, C. Mei, X. Liao, J. Bojar, R. Kuang, S. Rong, Q. Yao, J. Zhang, Y. S. 2023-07-20 doi:10.1101/2023.07.19.549787 Cold Spring Harbor Laboratory Press 2023-07-20 <![CDATA[ Contrasting roles of different mismatch repair proteins in basal-like breast cancer ]]> https://biorxiv.org/content/10.1101/2023.07.20.549745v1?rss=1 Mo, J. Borcherding, N. Jo, S. Tithi, T. I. Cho, E. Cash, C. E. Honda, M. Ahmed, K. K. kolb, R. Weigel, R. Spies, M. Zhang, W. 2023-07-22 doi:10.1101/2023.07.20.549745 Cold Spring Harbor Laboratory Press 2023-07-22 <![CDATA[ SYS-1/beta-catenin inheritance and regulation by Wnt-signaling during asymmetric cell division. ]]> https://biorxiv.org/content/10.1101/2023.07.21.550069v1?rss=1 Valdes Michel, M. F. Phillips, B. T. 2023-07-22 doi:10.1101/2023.07.21.550069 Cold Spring Harbor Laboratory Press 2023-07-22 <![CDATA[ Looking at the Full Picture: Utilizing Topic Modeling to Determine Disease-Associated Microbiome Communities ]]> https://biorxiv.org/content/10.1101/2023.07.21.549984v1?rss=1 Shrode, R. L. Ollberding, N. J. Mangalam, A. K. 2023-07-25 doi:10.1101/2023.07.21.549984 Cold Spring Harbor Laboratory Press 2023-07-25 <![CDATA[ Complementary cognitive roles for D2-MSNs and D1-MSNs in interval timing ]]> https://biorxiv.org/content/10.1101/2023.07.25.550569v1?rss=1 Bruce, R. Weber, M. A. Bova, A. Volkman, R. Jacobs, C. Sivakumar, K. Kim, Y. Curtu, R. Narayanan, N. 2023-07-28 doi:10.1101/2023.07.25.550569 Cold Spring Harbor Laboratory Press 2023-07-28 <![CDATA[ RBL2 represses the transcriptional activity of Multicilin to inhibit multiciliogenesis ]]> https://biorxiv.org/content/10.1101/2023.08.04.551992v1?rss=1 Quiroz, E. J. Kim, S. Gautam, L. K. Borok, Z. Kintner, C. Ryan, A. L. 2023-08-04 doi:10.1101/2023.08.04.551992 Cold Spring Harbor Laboratory Press 2023-08-04 <![CDATA[ Lateral Septal Circuits Govern Schizophrenic-Like Effects of Ketamine on Social Behavior ]]> https://biorxiv.org/content/10.1101/2023.08.08.552372v1?rss=1 Wang, R. Peterson, Z. J. Balasubramanian, N. Khan, K. M. Chimenti, M. S. Thedens, D. Nickl-Jockschat, T. Marcinkiewcz, C. 2023-08-08 doi:10.1101/2023.08.08.552372 Cold Spring Harbor Laboratory Press 2023-08-08 <![CDATA[ TMS provokes target-dependent intracranial rhythms across human cortical and subcortical sites ]]> https://biorxiv.org/content/10.1101/2023.08.09.552524v1?rss=1 Solomon, E. A. Wang, J. B. Oya, H. Howard, M. A. Trapp, N. T. Uitermarkt, B. D. Boes, A. D. Keller, C. J. 2023-08-14 doi:10.1101/2023.08.09.552524 Cold Spring Harbor Laboratory Press 2023-08-14 <![CDATA[ Generation of Human Regulatory Dendritic Cells from Cryopreserved Healthy Donor Cells and Hematopoietic Stem Cell Transplant Recipients ]]> https://biorxiv.org/content/10.1101/2023.08.11.552986v1?rss=1 Scroggins, S. M. Schlueter, A. J. 2023-08-14 doi:10.1101/2023.08.11.552986 Cold Spring Harbor Laboratory Press 2023-08-14 <![CDATA[ Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies. ]]> https://biorxiv.org/content/10.1101/2023.08.11.552990v1?rss=1 View larger version (25K): org.highwire.dtl.DTLVardef@1dcec56org.highwire.dtl.DTLVardef@1202a09org.highwire.dtl.DTLVardef@a7e7b6org.highwire.dtl.DTLVardef@15d8925_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Hong, L. Braden, d. C. Zhao, Y. Skoko, J. J. Chang, F. Woodcock, S. R. Uvale, C. Casey, A. Wood, K. Salavatore, S. Alp, A. Harkness, T. Fagunloye, A. Razzaghi, M. Straub, A. C. Spies, M. Brown, D. D. LEE, A. V. Schopfer, F. J. Freeman, B. A. Carola, C. A. 2023-08-14 doi:10.1101/2023.08.11.552990 Cold Spring Harbor Laboratory Press 2023-08-14 <![CDATA[ Cellular Immunotherapy in Mice Prevents Maternal Hyperten-sion and Restores Anti-Inflammatory Cytokine Balance in Ma-ternal and Fetal Tissues ]]> https://biorxiv.org/content/10.1101/2023.08.14.553300v1?rss=1 Gray, G. Scroggins, D. G. Wilson, K. T. Scroggins, S. M. 2023-08-14 doi:10.1101/2023.08.14.553300 Cold Spring Harbor Laboratory Press 2023-08-14 <![CDATA[ Efferent projections of Nps-expressing neurons in the parabrachial region ]]> https://biorxiv.org/content/10.1101/2023.08.13.553140v1?rss=1 Zhang, R. Huang, D. Gasparini, S. Geerling, J. C. 2023-08-15 doi:10.1101/2023.08.13.553140 Cold Spring Harbor Laboratory Press 2023-08-15 <![CDATA[ Endothelial Lipase Variant, T111I, Does Not Alter Inhibition by Angiopoietin-like Proteins ]]> https://biorxiv.org/content/10.1101/2023.08.18.553740v1?rss=1 Sylvers-Davie, K. L. Bierstedt, K. C. Schnieders, M. J. Davies, B. S. J. 2023-08-18 doi:10.1101/2023.08.18.553740 Cold Spring Harbor Laboratory Press 2023-08-18 <![CDATA[ Inverted U-shaped brain development of cognitive control across the human lifespan ]]> https://biorxiv.org/content/10.1101/2023.08.20.554018v1?rss=1 Yang, G. Li, Z. Petersen, I. T. Wang, L. Radua, J. Liu, X. 2023-08-21 doi:10.1101/2023.08.20.554018 Cold Spring Harbor Laboratory Press 2023-08-21 <![CDATA[ Brief excitotoxic insults cause a calpain-mediated increase in nuclear membrane permeability in neonatal neurons. ]]> https://biorxiv.org/content/10.1101/2023.08.22.554167v1?rss=1 Suryavanshi, P. Langton, R. Fairhead, K. Glykys, J. 2023-08-23 doi:10.1101/2023.08.22.554167 Cold Spring Harbor Laboratory Press 2023-08-23 <![CDATA[ Molecular fingerprints in the hippocampus of alcohol seeking during withdrawal ]]> https://biorxiv.org/content/10.1101/2023.08.24.554622v1?rss=1 View larger version (41K): org.highwire.dtl.DTLVardef@14b3fadorg.highwire.dtl.DTLVardef@141b1fdorg.highwire.dtl.DTLVardef@c82b8org.highwire.dtl.DTLVardef@15a16ad_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Pagano, R. Salamian, A. Skonieczna, E. Wojtas, B. Gielniewski, B. Harda, Z. Cały, A. Havekes, R. Abel, T. Radwaska, K. 2023-08-27 doi:10.1101/2023.08.24.554622 Cold Spring Harbor Laboratory Press 2023-08-27 <![CDATA[ Identifying critical language planning regions with direct electrical brain stimulation ]]> https://biorxiv.org/content/10.1101/2023.08.26.554639v1?rss=1 Castellucci, G. A. Kovach, C. K. Tabasi, F. Christianson, D. Greenlee, J. D. Long, M. A. 2023-08-28 doi:10.1101/2023.08.26.554639 Cold Spring Harbor Laboratory Press 2023-08-28 <![CDATA[ The geometry of photopolymerized topography influences neurite pathfinding by directing growth cone morphology and migration ]]> https://biorxiv.org/content/10.1101/2023.08.28.555111v1?rss=1 Vecchi, J. T. Rhomberg, M. Guymon, C. A. Hansen, M. R. 2023-08-29 doi:10.1101/2023.08.28.555111 Cold Spring Harbor Laboratory Press 2023-08-29 <![CDATA[ Survival in macrophages induces enhanced virulence in Cryptococcus ]]> https://biorxiv.org/content/10.1101/2023.09.03.556094v1?rss=1 Nielson, J. Jezewski, A. J. Wellington, M. Davis, J. M. 2023-09-03 doi:10.1101/2023.09.03.556094 Cold Spring Harbor Laboratory Press 2023-09-03 <![CDATA[ A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria ]]> https://biorxiv.org/content/10.1101/2023.09.01.555894v1?rss=1 Faniyan, T. S. Zhang, X. Morgan, D. A. Robles, J. Bathina, S. Perry, R. J. Brookes, P. S. Rahmouni, K. Chhabra, K. H. 2023-09-05 doi:10.1101/2023.09.01.555894 Cold Spring Harbor Laboratory Press 2023-09-05 <![CDATA[ The tumor microbiome reacts to hypoxia and can influence response to radiation treatment in colorectal cancer ]]> https://biorxiv.org/content/10.1101/2023.09.01.555936v1?rss=1 Benej, M. Hoyd, R. Kreamer, M. Wheeler, C. E. Grencewicz, D. J. Choueiry, F. Chan, C. H. Zakharia, Y. Ma, Q. Dodd, R. D. Ulrich, C. M. Hardikar, S. Churchman, M. L. Tarhini, A. A. Robinson, L. A. Singer, E. A. Ikeguchi, A. P. McCarter, M. D. Tinoco, G. Husain, M. Jin, N. Tan, A. C. Osman, A. E. G. Eljilany, I. Riedlinger, G. Schneider, B. P. Benejova, K. Kery, M. Papandreou, I. Zhu, J. Denko, N. Spakowicz, D. 2023-09-06 doi:10.1101/2023.09.01.555936 Cold Spring Harbor Laboratory Press 2023-09-06 <![CDATA[ Mitochondrial-nuclear variation for metabolic plasticity with potential consequences for invasion success in New Zealand mud snails ]]> https://biorxiv.org/content/10.1101/2023.09.02.556044v1?rss=1 Matoo, O. B. Mohammed, H. Patel, H. Neiman, M. Montooth, K. L. 2023-09-06 doi:10.1101/2023.09.02.556044 Cold Spring Harbor Laboratory Press 2023-09-06 <![CDATA[ Speciation in kleptoparasites of oak gall wasps often correlates with shifts into new tree habitats, tree organs, and gall morphospace ]]> https://biorxiv.org/content/10.1101/2023.09.07.556376v1?rss=1 Ward, A. Zhang, Y. M. Brown, G. E. Hippee, A. C. Prior, K. M. Rollins, S. Sierra, N. Sheikh, S. I. Tribull, C. M. Forbes, A. A. 2023-09-07 doi:10.1101/2023.09.07.556376 Cold Spring Harbor Laboratory Press 2023-09-07 <![CDATA[ Within-Host Bayesian Joint Modeling of Longitudinal and Time-to-Event Data of Leishmania Infection ]]> https://biorxiv.org/content/10.1101/2023.09.11.557114v1?rss=1 Pabon-Rodriguez, F. Brown, G. D. Scorza, B. M. Petersen, C. A. 2023-09-14 doi:10.1101/2023.09.11.557114 Cold Spring Harbor Laboratory Press 2023-09-14 <![CDATA[ MixOmics Integration of Biological Datasets Identifies Highly Correlated Key Variables of COVID-19 severity. ]]> https://biorxiv.org/content/10.1101/2023.09.14.557558v1?rss=1 Harriott, N. C. Chimenti, M. S. Ryan, A. L. 2023-09-15 doi:10.1101/2023.09.14.557558 Cold Spring Harbor Laboratory Press 2023-09-15 <![CDATA[ A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution ]]> https://biorxiv.org/content/10.1101/2023.09.18.558047v1?rss=1 Nardone, S. De Luca, R. Zito, A. Klymko, N. Nicoloutsopoulos, D. Amsalem, O. Brannigan, C. Resch, J. M. Jacobs, C. L. Pant, D. Veregge, M. Srinivasan, H. Grippo, R. M. Yang, Z. Zeidel, M. L. Andermann, M. L. Harris, K. D. Tsai, L. T. Arrigoni, E. Verstegen, A. M. J. Saper, C. B. Lowell, B. B. 2023-09-18 doi:10.1101/2023.09.18.558047 Cold Spring Harbor Laboratory Press 2023-09-18 <![CDATA[ Erdr1 orchestrates macrophage polarization and determines cell fate via dynamic interaction with YAP1 and Mid1 ]]> https://biorxiv.org/content/10.1101/2023.09.17.557960v1?rss=1 Wang, Y. 2023-09-19 doi:10.1101/2023.09.17.557960 Cold Spring Harbor Laboratory Press 2023-09-19 <![CDATA[ Enhanced ISGylation reduces respiratory distress following Francisella novicida infection ]]> https://biorxiv.org/content/10.1101/2023.09.19.558558v1?rss=1 Upton, E. M. Luhmann, E. K. Zhang, Y. Ripley, B. M. Meyerholz, D. K. Radoshevich, L. 2023-09-20 doi:10.1101/2023.09.19.558558 Cold Spring Harbor Laboratory Press 2023-09-20 <![CDATA[ Comparative dynamics of gene expression during in vitro and in vivo Candida albicans filamentation. ]]> https://biorxiv.org/content/10.1101/2023.09.21.558874v1?rss=1 Wakade, R. S. Krysan, D. J. 2023-09-21 doi:10.1101/2023.09.21.558874 Cold Spring Harbor Laboratory Press 2023-09-21 <![CDATA[ Short-term statin treatment reduces, and long-term statin treatment abolishes chronic vascular injury by radiation therapy ]]> https://biorxiv.org/content/10.1101/2023.09.20.558723v1?rss=1 Ait-Aissa, K. Guo, X. Klemmensen, M. Juhr, D. Leng, L. N. Koval, O. M. Grumbach, I. M. 2023-09-22 doi:10.1101/2023.09.20.558723 Cold Spring Harbor Laboratory Press 2023-09-22 <![CDATA[ Activity-induced gene expression in the human brain ]]> https://biorxiv.org/content/10.1101/2023.09.21.558812v1?rss=1 Chatterjee, S. Park, B. J. Vanrobaeys, Y. Heiney, S. A. Rhone, A. E. Nourski, K. V. Langmack, L. Mukherjee, U. Kovach, C. K. Kocsis, Z. Kikuchi, Y. Petkov, C. I. Hefti, M. M. Bahl, E. Michaelson, J. J. Kawasaki, H. Oya, H. Howard, M. A. Nickl-Jockschat, T. Lin, L.-C. Abel, T. 2023-09-22 doi:10.1101/2023.09.21.558812 Cold Spring Harbor Laboratory Press 2023-09-22 <![CDATA[ Quantitative Assessment of Morphological Changes in Lipid Droplets and Lipid-Mito Interactions with Aging in Brown Adipose ]]> https://biorxiv.org/content/10.1101/2023.09.23.559135v1?rss=1 View larger version (27K): org.highwire.dtl.DTLVardef@e5b7org.highwire.dtl.DTLVardef@e965e5org.highwire.dtl.DTLVardef@120c7e9org.highwire.dtl.DTLVardef@124bfb5_HPS_FORMAT_FIGEXP M_FIG Graphical Abstract Workflow highlighting the process of murine interscapular BAT extraction, processing and imaging serial block facing-scanning electron microscopy and using Amira software for 3D reconstruction of LDs and mitochondrial lipid contact sites to elucidate their structure across aging. C_FIG ]]> Crabtree, A. Neikirk, K. Whiteside, A. McKenzie, J. Vue, Z. Vang, L. Owens, T. C. Oliver, A. Zeleke, F. Beasley, H. K. Garza-Lopez, E. Scudese, E. Koh, A. Navarro, S. Lam, J. Kirk, B. Mungai, M. Sweetwyne, M. T. Koh, H.-J. Zaganjor, E. Damo, S. M. Gaddy, J. A. Williams, C. McReynolds, M. Marshall, A. G. Hinton, A. 2023-09-26 doi:10.1101/2023.09.23.559135 Cold Spring Harbor Laboratory Press 2023-09-26 <![CDATA[ An enhancer RNA recruits MLL1 to regulate transcription of Myb ]]> https://biorxiv.org/content/10.1101/2023.09.26.559528v1?rss=1 Kim, J. Diaz, L. F. Miller, M. J. Leadem, B. Krivega, I. Dean, A. 2023-09-26 doi:10.1101/2023.09.26.559528 Cold Spring Harbor Laboratory Press 2023-09-26 <![CDATA[ Identification of Host Restriction Factors Critical for Recombinant AAV Transduction of Polarized Human Airway Epithelium ]]> https://biorxiv.org/content/10.1101/2023.09.27.559795v1?rss=1 Hao, S. Zhang, X. Ning, K. Feng, Z. Park, S. Y. Kuz, C. A. McFarlin, S. Richart, D. Cheng, F. Zhang, E. Y. Zhang-Chen, A. Yan, Z. Qiu, J. 2023-09-27 doi:10.1101/2023.09.27.559795 Cold Spring Harbor Laboratory Press 2023-09-27 <![CDATA[ Evidence of antigenic drift in the fusion machinery core of SARS-CoV-2 spike ]]> https://biorxiv.org/content/10.1101/2023.09.27.559757v1?rss=1 Tan, T. J. C. Odle, A. Lei, R. Matreyek, K. A. Perlman, S. Wong, L.-Y. R. Wu, N. C. 2023-09-28 doi:10.1101/2023.09.27.559757 Cold Spring Harbor Laboratory Press 2023-09-28 <![CDATA[ Pre-clinical Evaluation of Biomarkers for Early Detection of Nephrotoxicity Following Alpha-particle Radioligand Therapy ]]> https://biorxiv.org/content/10.1101/2023.09.27.559789v1?rss=1 Li, M. Robles-Planells, C. Liu, D. Graves, S. A. Vasquez-Martinez, G. Mayoral-Andrade, G. Lee, D. Rastogi, P. Marks, B. M. Sagastume, E. A. Weiss, R. M. Linn-Peirano, S. C. Johnson, F. L. Schultz, M. K. Zepeda-Orozco, D. 2023-09-29 doi:10.1101/2023.09.27.559789 Cold Spring Harbor Laboratory Press 2023-09-29 <![CDATA[ Enhanced spine stability and survival lead to increases in dendritic spine density as an early response to local alpha-synuclein overexpression in mouse prefrontal cortex ]]> https://biorxiv.org/content/10.1101/2023.09.28.559765v1?rss=1 Bosch, P. J. Kerr, G. Cole, R. C. Warwick, C. A. Wendt, L. H. Pradeep, A. Bagnall, E. Aldridge, G. 2023-09-29 doi:10.1101/2023.09.28.559765 Cold Spring Harbor Laboratory Press 2023-09-29 <![CDATA[ Disease-specific selective vulnerability and neuroimmune pathways in dementia revealed by single cellgenomics ]]> https://biorxiv.org/content/10.1101/2023.09.29.560245v1?rss=1 Rexach, J. E. Cheng, Y. Chen, L. Polioudakis, D. Lin, L.-C. Mitri, V. Elkins, A. Yin, A. Calini, D. Kawaguchi, R. Ou, J. Huang, J. Williams, C. Robinson, J. Gaus, S. Spina, S. Lee, E. Grinberg, L. Vinters, H. Trojanowski, J. Seeley, W. Molhatra, D. Geschwind, D. 2023-09-30 doi:10.1101/2023.09.29.560245 Cold Spring Harbor Laboratory Press 2023-09-30 <![CDATA[ Resident Synovial Macrophages in Synovial Fluid: Implications for Immunoregulation in Infectious and Inflammatory Arthritis ]]> https://biorxiv.org/content/10.1101/2023.09.29.560183v1?rss=1 Cyndari, K. I. Scorza, B. M. I. Zacharias, Z. R. Strand, L. Mahachi, K. Oviedo, J. M. Gibbs, L. Pessoa-Pereira, D. Ausdal, G. Hendricks, D. Yahashiri, R. Elkins, J. M. Gulbrandsen, T. Peterson, A. R. Willey, M. C. Fairfax, K. C. Petersen, C. A. A. 2023-10-02 doi:10.1101/2023.09.29.560183 Cold Spring Harbor Laboratory Press 2023-10-02 <![CDATA[ CaCO3 Nanoparticles Delivering MicroRNA-200c Suppress Oral Squamous Cell Carcinoma ]]> https://biorxiv.org/content/10.1101/2023.10.05.561110v1?rss=1 Ding, Q. Remy, M. T. Upara, C. Hu, J. Mata, A. M. Haes, A. J. Lanzel, E. Sun, H. Buchakjian, M. Hong, L. 2023-10-05 doi:10.1101/2023.10.05.561110 Cold Spring Harbor Laboratory Press 2023-10-05 <![CDATA[ Architecture and rearrangements of a sperm-specific Na+/H+ exchanger ]]> https://biorxiv.org/content/10.1101/2023.10.04.560940v1?rss=1 Pal, K. Chowdhury, S. 2023-10-06 doi:10.1101/2023.10.04.560940 Cold Spring Harbor Laboratory Press 2023-10-06 <![CDATA[ Neuroprotective Effects of Naltrexone in a Mouse Model of Post-Traumatic Epilepsy ]]> https://biorxiv.org/content/10.1101/2023.10.04.560949v1?rss=1 Rodriguez, S. Sharma, S. Tiarks, G. Peterson, Z. Jackson, K. Thedens, D. R. Wong, A. Keffala-Gerhard, D. Mahajan, V. B. Ferguson, P. J. Newell, E. Glykys, J. Nickl-Jockschat, T. Bassuk, A. G. 2023-10-06 doi:10.1101/2023.10.04.560949 Cold Spring Harbor Laboratory Press 2023-10-06 <![CDATA[ Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model ]]> https://biorxiv.org/content/10.1101/2023.10.06.560776v1?rss=1 Bottom-Tanzer, S. Corella, S. Meyer, J. Sommer, M. Bolanos, L. Murphy, T. Quinones, S. Heiney, S. Shtrahman, M. Whalen, M. Oren, R. Higley, M. J. Cardin, J. A. Noubary, F. Armbruster, M. Dulla, C. 2023-10-06 doi:10.1101/2023.10.06.560776 Cold Spring Harbor Laboratory Press 2023-10-06 <![CDATA[ Genetic and pharmacologic alterations of claudin9 levels suffice to induce functional and mature inner hair cells ]]> https://biorxiv.org/content/10.1101/2023.10.08.561387v1?rss=1 50% of the mouses life cycle. In vivo, Cldn9 knockdown using shRNA on postnatal days (P) P2-7 yielded analogous functional ectopic IHCs that were equally durably conserved. The findings suggest that Cldn9 levels coordinate embryonic and postnatal HC differentiation, making it a viable target for altering IHC development pre- and post-terminal differentiation. ]]> Chen, Y. Lee, J. H. H. Li, J. Park, S. Perez-Flores, M. C. Peguero, B. Kersigo, J. Kang, M. Choi, J. Levine, L. Gratton, M. A. Friztsch, B. Yamoah, E. N. 2023-10-10 doi:10.1101/2023.10.08.561387 Cold Spring Harbor Laboratory Press 2023-10-10 <![CDATA[ An osmolarity dependent mechanism partially ameliorates retinal cysts and rescues cone function in a mouse model of X-linked Retinoschisis. ]]> https://biorxiv.org/content/10.1101/2023.10.09.561513v1?rss=1 Gehrke, E. J. Thompson, J. Kalmanek, E. Stanley, S. T. Bhattarai, S. Lobeck, B. Mayer, S. K. Mahoney, A. Hassan, S. Hsu, Y. Drack, A. 2023-10-11 doi:10.1101/2023.10.09.561513 Cold Spring Harbor Laboratory Press 2023-10-11 <![CDATA[ Biodistribution Analysis of Peptide-Coated Magnetic Iron Nanoparticles: A Simple and Quantitative Method ]]> https://biorxiv.org/content/10.1101/2023.10.11.561862v1?rss=1 Natarajan, P. Horak, K. Rowe, J. Joshua, L. J. Tomich, J. Fleming, S. 2023-10-11 doi:10.1101/2023.10.11.561862 Cold Spring Harbor Laboratory Press 2023-10-11 <![CDATA[ Sensing, Feeling, and Regulating: Investigating the Association of Focal Brain Damage with Voluntary Respiratory and Motor Control ]]> https://biorxiv.org/content/10.1101/2023.10.16.562254v1?rss=1 Bischoff, H. Kovach, C. K. Kumar, S. Bruss, J. Tranel, D. Khalsa, S. S. 2023-10-17 doi:10.1101/2023.10.16.562254 Cold Spring Harbor Laboratory Press 2023-10-17 <![CDATA[ Excess neonatal testosterone causes male-specific social and fear memory deficits in wild-type mice ]]> https://biorxiv.org/content/10.1101/2023.10.18.562939v1?rss=1 Quinones-Labernik, P. Blocklinger, K. L. Bruce, M. R. Ferri, S. L. 2023-10-19 doi:10.1101/2023.10.18.562939 Cold Spring Harbor Laboratory Press 2023-10-19 <![CDATA[ A gene selection analysis of TAS1R1 and TAS1R3 to examine human carnivory ]]> https://biorxiv.org/content/10.1101/2023.10.17.562619v1?rss=1 Cross, M. Kitchen, A. 2023-10-20 doi:10.1101/2023.10.17.562619 Cold Spring Harbor Laboratory Press 2023-10-20 <![CDATA[ (1->3)-β-D-glucan derivatives with unique structural properties differentially affect murine lung inflammation and histology. ]]> https://biorxiv.org/content/10.1101/2023.10.18.562993v1?rss=1 Metwali, N. Stapleton, E. Hadina, S. Thorne, P. S. 2023-10-20 doi:10.1101/2023.10.18.562993 3)-β-D-glucan derivatives with unique structural properties differentially affect murine lung inflammation and histology.]]> Cold Spring Harbor Laboratory Press 2023-10-20 <![CDATA[ Missense mutations in Myc Box I influence MYC cellular localization, mRNA partitioning and turnover to promote leukemogenesis ]]> https://biorxiv.org/content/10.1101/2023.10.22.563493v1?rss=1 Arthur, N. Christensen, K. A. Mannino, K. Ruzinova, M. Kumar, A. Gruszczynska, A. Day, R. B. Erdmann-Gilmore, P. Mi, Y. Sprung, R. York, C. R. Spencer, D. H. Townsend, R. Sykes, S. M. Ferraro, F. 2023-10-24 doi:10.1101/2023.10.22.563493 Cold Spring Harbor Laboratory Press 2023-10-24 <![CDATA[ Regulator of G protein signaling 6 (RGS6) in ventral tegmental area (VTA) dopamine neurons promotes EtOH seeking, behavioral reward and susceptibility to relapse ]]> https://biorxiv.org/content/10.1101/2023.10.24.563844v1?rss=1 Spicer, M. M. Weber, M. A. Luo, Z. Yang, J. Narayanan, N. S. Fisher, R. A. 2023-10-25 doi:10.1101/2023.10.24.563844 Cold Spring Harbor Laboratory Press 2023-10-25 <![CDATA[ Biophysical modeling of frontocentral ERP generation links circuit-level mechanisms of action-stopping to a behavioral race model ]]> https://biorxiv.org/content/10.1101/2023.10.25.564020v1?rss=1 Diesburg, D. A. Wessel, J. R. Jones, S. 2023-10-30 doi:10.1101/2023.10.25.564020 Cold Spring Harbor Laboratory Press 2023-10-30 <![CDATA[ NREM sleep oscillations and their relations with sleep-dependent memory consolidation in early course psychosis and first-degree relatives ]]> https://biorxiv.org/content/10.1101/2023.10.30.564703v1?rss=1 Denis, D. Baran, B. Mylonas, D. Spitzer, C. Raymond, N. Talbot, C. Kohnke, E. Stickgold, R. Keshavan, M. Manoach, D. S. 2023-11-02 doi:10.1101/2023.10.30.564703 Cold Spring Harbor Laboratory Press 2023-11-02 <![CDATA[ Genome evolution and introgression in the New Zealand mud snails Potamopyrgus estuarinus and Potamopyrgus kaitunuparaoa ]]> https://biorxiv.org/content/10.1101/2023.10.31.565016v1?rss=1 Fields, P. Jalinsky, J. Bankers, L. McElroy, K. Sharbrough, J. Higgins, C. Morgan-Richards, M. Boore, J. Neiman, M. Logsdon, J. M. 2023-11-02 doi:10.1101/2023.10.31.565016 Cold Spring Harbor Laboratory Press 2023-11-02 <![CDATA[ Brain-derived neurotrophic factor contributes to activity-induced muscle pain in male but not female mice ]]> https://biorxiv.org/content/10.1101/2023.10.31.565022v1?rss=1 Hayashi, K. Lesnak, J. B. Plumb, A. N. Janowski, A. J. Smith, A. F. Hill, J. K. Sluka, K. A. 2023-11-02 doi:10.1101/2023.10.31.565022 Cold Spring Harbor Laboratory Press 2023-11-02 <![CDATA[ Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD) ]]> https://biorxiv.org/content/10.1101/2023.11.01.565230v1?rss=1 Zhang, T. Ambrodji, A. Huang, H. Bouchonville, K. J. Etheridge, A. S. Schmidt, R. E. Bembenek, B. M. Temesgen, Z. B. Wang, Z. Innocenti, F. Stroka, D. Diasio, R. B. Largiader, C. R. Offer, S. 2023-11-05 doi:10.1101/2023.11.01.565230 Cold Spring Harbor Laboratory Press 2023-11-05 <![CDATA[ Inhibition of noradrenaline-dependent synaptic transmission in the dorsal raphe nucleus by alpha2-adrenergic receptors ]]> https://biorxiv.org/content/10.1101/2023.11.07.566093v1?rss=1 Gugel, A. Ingebretsen, E. A. Hake, H. S. Gantz, S. C. 2023-11-07 doi:10.1101/2023.11.07.566093 Cold Spring Harbor Laboratory Press 2023-11-07 <![CDATA[ A Method for Analyzing AFM Force Mapping Data Obtained from Soft Tissue Cryosections ]]> https://biorxiv.org/content/10.1101/2023.11.08.566263v1?rss=1 Wong, C. A. Fraticelli Guzman, N. S. Read, A. T. Hedberg-Buenz, A. Anderson, M. G. Feola, A. J. Sulchek, T. Ethier, C. R. 2023-11-13 doi:10.1101/2023.11.08.566263 Cold Spring Harbor Laboratory Press 2023-11-13 <![CDATA[ A double-ring of human RAD52 remodels replication forks restricting fork reversal ]]> https://biorxiv.org/content/10.1101/2023.11.14.566657v1?rss=1 Honda, M. Razzaghi, M. Gaur, P. Malacaria, E. Di Biagi, L. Aiello, F. A. Paintsil, E. A. Stanfield, A. Deppe, B. J. Gakhar, L. Schnicker, N. J. Spies, M. A. Pichierri, P. Spies, M. 2023-11-14 doi:10.1101/2023.11.14.566657 Cold Spring Harbor Laboratory Press 2023-11-14 <![CDATA[ AptamerRunner: An accessible aptamer structure prediction and clustering algorithm for visualization of selected aptamers ]]> https://biorxiv.org/content/10.1101/2023.11.13.566453v1?rss=1 View larger version (23K): org.highwire.dtl.DTLVardef@f63049org.highwire.dtl.DTLVardef@dc26dcorg.highwire.dtl.DTLVardef@17b7381org.highwire.dtl.DTLVardef@1dc39af_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Ruiz-Ciancio, D. Veeramani, S. Embree, E. Ortman, C. Thiel, K. W. Thiel, W. 2023-11-15 doi:10.1101/2023.11.13.566453 Cold Spring Harbor Laboratory Press 2023-11-15 <![CDATA[ 3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights into MFN-2 Mediated Changes ]]> https://biorxiv.org/content/10.1101/2023.11.13.566502v1?rss=1 View larger version (48K): org.highwire.dtl.DTLVardef@1d2be0eorg.highwire.dtl.DTLVardef@bba6caorg.highwire.dtl.DTLVardef@1c335e5org.highwire.dtl.DTLVardef@10789c9_HPS_FORMAT_FIGEXP M_FIG O_FLOATNOGraphical Abstract:C_FLOATNO Age-related skeletal muscle atrophy shows morphological alterations in mitochondrial structure associated with declining function. Our findings propose that exercise intervention may counteract these structural declines by reinstating levels of mitofusin 2, thus highlighting a potential mechanism by which exercise attenuates age-induced mitochondrial dysfunction. C_FIG ]]> Scudese, E. Vue, Z. Katti, P. Marshall, A. Vang, L. Garza Lopez, E. Neikirk, K. Stephens, D. Hall, D. D. Rostami, R. Shao, J.-q. Mungai, M. AshShareef, S. Hicsasmaz, I. Manus, S. Whiteside, A. Williams, C. Damo, S. Gaddy, J. Kirabo, A. Glancy, B. Henrique Martin Dantas, E. Kinder, A. Scartoni, F. Baffi, M. McReynolds, M. Wanjalla, C. N. Phillips, M. A. Exil, V. Mobley, B. Hinton, A. 2023-11-15 doi:10.1101/2023.11.13.566502 Cold Spring Harbor Laboratory Press 2023-11-15 <![CDATA[ Multiplexed live-cell imaging for drug responses in patient-derived organoid models of cancer ]]> https://biorxiv.org/content/10.1101/2023.11.15.567243v1?rss=1 Colling, K. E. Symons, E. L. Buroni, L. Sumanasiri, H. K. Andrew-Udoh, J. Witt, E. Losh, H. A. Morrison, A. M. Leslie, K. K. Dunnill, C. J. De Bono, J. S. Thiel, K. W. 2023-11-17 doi:10.1101/2023.11.15.567243 Cold Spring Harbor Laboratory Press 2023-11-17 <![CDATA[ CRF release from a unique subpopulation of accumbal neurons constrains action-outcome acquisition in reward learning ]]> https://biorxiv.org/content/10.1101/2023.11.16.567495v1?rss=1 Eckenwiler, E. A. Ingebretson, A. E. Stolley, J. J. Petersen, C. L. Fusaro, M. A. Ross, J. M. Romportl, A. M. Kale, E. M. Clark, M. S. Lemos, J. C. 2023-11-17 doi:10.1101/2023.11.16.567495 Cold Spring Harbor Laboratory Press 2023-11-17 <![CDATA[ Generation of site-specifically labelled fluorescent human XPA to investigate DNA binding dynamics during nucleotide excision repair ]]> https://biorxiv.org/content/10.1101/2023.11.23.568461v1?rss=1 Kuppa, S. Corless, E. Caldwell, C. C. Spies, M. Antony, E. 2023-11-23 doi:10.1101/2023.11.23.568461 Cold Spring Harbor Laboratory Press 2023-11-23 <![CDATA[ Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning ]]> https://biorxiv.org/content/10.1101/2023.11.28.569051v1?rss=1 Lei, R. Qing, E. Odle, A. Yuan, M. Tan, T. J. C. So, N. Ouyang, W. O. Wilson, I. A. Gallagher, T. Perlman, S. Wu, N. C. Wong, L. Y. R. 2023-11-29 doi:10.1101/2023.11.28.569051 Cold Spring Harbor Laboratory Press 2023-11-29 <![CDATA[ Human Heart Failure Alters Mitochondria and Fiber 3D Structure Triggering Metabolic Shifts ]]> https://biorxiv.org/content/10.1101/2023.11.28.569095v1?rss=1 Vue, Z. Ajayi, P. T. Neikirk, K. Murphy, A. Prasad, P. Jenkins, B. C. Vang, L. Garza-Lopez, E. Mungai, M. Marshall, A. G. Beasley, H. K. Killion, M. Parker, R. Anukodem, J. Lavine, K. Ajijola, O. Mobley, B. Dai, D.-F. Exil, V. Kirabo, A. Ru Su, Y. Tomasek, K. Zhang, X. Wanjalla, C. N. Hubert, D. L. Phillips, M. A. McReynolds, M. Glancy, B. Hinton, A. 2023-11-30 doi:10.1101/2023.11.28.569095 Cold Spring Harbor Laboratory Press 2023-11-30 <![CDATA[ Dilated cardiomyopathy-associated RNA Binding Motif Protein 20 regulates long pre-mRNAs in neurons ]]> https://biorxiv.org/content/10.1101/2023.12.06.570345v1?rss=1 Scheiffele, P. Di Bartolomei, G. Ortiz, R. Schreiner, D. Falkner, S. Creemers, E. E. 2023-12-06 doi:10.1101/2023.12.06.570345 Cold Spring Harbor Laboratory Press 2023-12-06 <![CDATA[ Temporal dynamics and representational consequences of the control of processing conflict between visual working memory and visual perception ]]> https://biorxiv.org/content/10.1101/2023.12.07.570647v1?rss=1 Teng, C. Fulvio, J. M. Pietrelli, M. Jiang, J. Postle, B. R. 2023-12-08 doi:10.1101/2023.12.07.570647 Cold Spring Harbor Laboratory Press 2023-12-08 <![CDATA[ Molecular Determinants and Signaling Effects of PKA RIα Phase Separation ]]> https://biorxiv.org/content/10.1101/2023.12.10.570836v1?rss=1 Hardy, J. C. Pool, E. H. Bruystens, J. G. H. Zhou, X. Li, Q. Zhou, D. R. Palay, M. Tan, G. Chen, L. Choi, J. L. C. Lee, H. N. Strack, S. Wang, D. Taylor, S. S. Mehta, S. Zhang, J. 2023-12-11 doi:10.1101/2023.12.10.570836 Cold Spring Harbor Laboratory Press 2023-12-11 <![CDATA[ The role of the C. albicans transcriptional repressor NRG1 during filamentation and disseminated candidiasis is strain-dependent ]]> https://biorxiv.org/content/10.1101/2023.12.15.571891v1?rss=1 Wakade, R. S. Wellington, M. Krysan, D. J. 2023-12-15 doi:10.1101/2023.12.15.571891 Cold Spring Harbor Laboratory Press 2023-12-15 <![CDATA[ Developmentally unique cerebellar processing prioritizes self- over other-generated movements ]]> https://biorxiv.org/content/10.1101/2023.12.16.571990v1?rss=1 Richardson, A. M. Sokoloff, G. Blumberg, M. S. 2023-12-16 doi:10.1101/2023.12.16.571990 Cold Spring Harbor Laboratory Press 2023-12-16 <![CDATA[ A neural network for religious fundamentalism derived from patients with brain lesions ]]> https://biorxiv.org/content/10.1101/2023.12.22.572527v1?rss=1 Ferguson, M. A. Asp, E. W. Kletenik, I. Tranel, D. Boes, A. Nelson, J. M. Schaper, F. L. Siddiqi, S. H. Anderson, J. S. Nielsen, J. A. Bateman, J. R. Grafman, J. Fox, M. D. 2023-12-29 doi:10.1101/2023.12.22.572527 Cold Spring Harbor Laboratory Press 2023-12-29 <![CDATA[ A new insight into the role of CART peptide in serotonergic function and anxiety ]]> https://biorxiv.org/content/10.1101/2024.01.22.576719v1?rss=1 Balasubramanian, N. Wang, R. Ismail, S. Hartman, B. Aboushaar, Z. Marcinkiewcz, C. A. 2024-01-22 doi:10.1101/2024.01.22.576719 Cold Spring Harbor Laboratory Press 2024-01-22 <![CDATA[ P66Shc Mediates SUMO2-induced Endothelial Dysfunction ]]> https://biorxiv.org/content/10.1101/2024.01.24.577109v1?rss=1 Kumar, J. Uppulapu, s. K. Kumari, S. Sharma, K. Paradee, W. J. Yadav, R. P. Kumar, V. Kumar, S. 2024-01-26 doi:10.1101/2024.01.24.577109 Cold Spring Harbor Laboratory Press 2024-01-26 <![CDATA[ Gammaherpesvirus infection alters transfer RNA splicing and triggers tRNA cleavage ]]> https://biorxiv.org/content/10.1101/2024.02.16.580780v1?rss=1 Manning, A. C. Bashir, M. M. Jimenez, A. C. Upton, H. E. Collins, K. Lowe, T. M. Tucker, J. M. 2024-02-17 doi:10.1101/2024.02.16.580780 Cold Spring Harbor Laboratory Press 2024-02-17 <![CDATA[ A chromosome-level genome assembly of Drosophila madeirensis, a fruit fly species endemic to the island of Madeira ]]> https://biorxiv.org/content/10.1101/2024.02.21.581469v1?rss=1 Tomihara, K. Llopart, A. Yamamoto, D. 2024-02-23 doi:10.1101/2024.02.21.581469 Cold Spring Harbor Laboratory Press 2024-02-23 <![CDATA[ Spiral ganglion neuron degeneration in deafened rats involves innate and adaptive immune responses not requiring complement ]]> https://biorxiv.org/content/10.1101/2024.02.21.581500v1?rss=1 Gansemer, B. M. Rahman, M. T. Zhang, Z. Green, S. H. 2024-02-23 doi:10.1101/2024.02.21.581500 Cold Spring Harbor Laboratory Press 2024-02-23 <![CDATA[ Conformational landscape of soluble α-klotho revealed by cryogenic electron microscopy ]]> https://biorxiv.org/content/10.1101/2024.03.02.583144v1?rss=1 Schnicker, N. J. Xu, Z. Amir, M. Gakhar, L. Huang, C.-L. 2024-03-06 doi:10.1101/2024.03.02.583144 Cold Spring Harbor Laboratory Press 2024-03-06 <![CDATA[ The Compensatory Mechanism of the Prefrontal Cortex in Preserving Speech-in-Noise Comprehension Among Older Adults ]]> https://biorxiv.org/content/10.1101/2024.03.08.584193v1?rss=1 Li, Z. Liu, Y. Zhang, X. Kou, N. Zhao, X. Jiang, X. Zhang, D. Wang, S. 2024-03-13 doi:10.1101/2024.03.08.584193 Cold Spring Harbor Laboratory Press 2024-03-13 <![CDATA[ Distinct intersecting pathways link homolog pairing to initiation of meiotic chromosome synapsis ]]> https://biorxiv.org/content/10.1101/2024.03.11.584447v1?rss=1 Blazickova, J. Trivedi, S. Bowman, R. Geetha, S. S. Subah, S. Smolikove, S. Jantsch, V. Zetka, M. Silva, N. 2024-03-12 doi:10.1101/2024.03.11.584447 Cold Spring Harbor Laboratory Press 2024-03-12 <![CDATA[ Defects in exosome biogenesis are associated with sensorimotor defects in zebrafish vps4a mutants ]]> https://biorxiv.org/content/10.1101/2024.03.13.584854v1?rss=1 Shipman, A. Gao, Y. Liu, D. Sun, S. Zang, J. Syed, Z. Bhagavathi, A. Smith, E. Erickson, T. Hill, M. Neuhauss, S. C. Sui, S.-F. Nicolson, T. 2024-03-14 doi:10.1101/2024.03.13.584854 Cold Spring Harbor Laboratory Press 2024-03-14 <![CDATA[ Identification of a new family of peptidoglycan transpeptidases reveals atypical crosslinking is essential for viability in Clostridioides difficile ]]> https://biorxiv.org/content/10.1101/2024.03.14.584917v1?rss=1 Bollinger, K. W. Muh, U. Ocius, K. L. Apostolos, A. J. Pires, M. M. Helm, R. F. Popham, D. L. Weiss, D. S. Ellermeier, C. D. 2024-03-14 doi:10.1101/2024.03.14.584917 Cold Spring Harbor Laboratory Press 2024-03-14 <![CDATA[ Molecular basis for the activation of the Fatty Acid Kinase complex of Staphylococcus aureus ]]> https://biorxiv.org/content/10.1101/2024.03.19.585040v1?rss=1 Myers, M. J. Xu, Z. Ryan, B. J. DeMars, Z. R. Ridder, M. J. Johnson, D. K. Krute, C. N. Flynn, T. S. Kashipathy, M. M. Battaile, K. P. Schnicker, N. J. Lovell, S. Freudenthal, B. D. Bose, J. L. 2024-03-19 doi:10.1101/2024.03.19.585040 Cold Spring Harbor Laboratory Press 2024-03-19 <![CDATA[ Host cell-specific metabolism of linoleic acid controls Toxoplasma gondii growth in cell culture ]]> https://biorxiv.org/content/10.1101/2024.03.22.586332v1?rss=1 Hryckowian, N. D. Zinda, C. Park, S. C. Kelty, M. T. Knoll, L. J. 2024-03-23 doi:10.1101/2024.03.22.586332 Cold Spring Harbor Laboratory Press 2024-03-23 <![CDATA[ Repetitive head impacts induce neuronal loss and neuroinflammation in young athletes ]]> https://biorxiv.org/content/10.1101/2024.03.26.586815v1?rss=1 Butler, M. L. M. D. Pervaiz, N. Ypsilantis, P. Wang, Y. Breda, J. C. Mazzilli, S. A. Nicks, R. Spurlock, E. Hefti, M. M. Huber, B. R. Alvarez, V. E. Stein, T. D. Campbell, J. D. McKee, A. C. Cherry, J. D. 2024-03-28 doi:10.1101/2024.03.26.586815 Cold Spring Harbor Laboratory Press 2024-03-28 <![CDATA[ CDHu40: a novel marker gene set of neuroendocrine prostate cancer (NEPC) ]]> https://biorxiv.org/content/10.1101/2024.03.28.587205v1?rss=1 Liu, S. Nam, H. S. Zeng, Z. Deng, X. Pashaei, E. Zang, Y. Yang, L. Li, C. Huang, J. Wendt, M. K. Lu, X. Huang, R. Wan, J. 2024-03-31 doi:10.1101/2024.03.28.587205 Cold Spring Harbor Laboratory Press 2024-03-31 <![CDATA[ Axonal organelle buildup from loss of AP-4 complex function causes exacerbation of amyloid plaque pathology and gliosis in Alzheimers disease mouse model ]]> https://biorxiv.org/content/10.1101/2024.03.31.587499v1?rss=1 Orlowski, A. Karippaparambil, J. Paumier, J.-M. Ghanta, S. Pallares, E. Tandukar, J. Gao, R. Gowrishankar, S. 2024-04-01 doi:10.1101/2024.03.31.587499 Cold Spring Harbor Laboratory Press 2024-04-01 <![CDATA[ Pseudomonas aeruginosa surface motility and invasion into competing communities enhances interspecies antagonism ]]> https://biorxiv.org/content/10.1101/2024.04.03.588010v1?rss=1 Sanchez-Pena, A. Winans, J. B. Nadell, C. D. Limoli, D. H. 2024-04-07 doi:10.1101/2024.04.03.588010 Cold Spring Harbor Laboratory Press 2024-04-07 <![CDATA[ Ipsilateral or contralateral boosting of mice with mRNA vaccines confers equivalent immunity and protection against a SARS-CoV-2 Omicron strain ]]> https://biorxiv.org/content/10.1101/2024.04.05.588051v1?rss=1 Ying, B. Liang, C.-Y. Desai, P. Scheaffer, S. Elbashir, S. Edwards, D. K. Thackray, L. B. Diamond, M. S. 2024-04-07 doi:10.1101/2024.04.05.588051 Cold Spring Harbor Laboratory Press 2024-04-07 <![CDATA[ Integrated multiomic analysis identifies TRIP13 as a mediator of alveolar epithelial type II cell dysfunction in idiopathic pulmonary fibrosis ]]> https://biorxiv.org/content/10.1101/2024.04.05.588292v1?rss=1 St. Pierre, L. Berhan, A. Sung, E. K. Alvarez, J. R. Wang, H. Ji, Y. Liu, Y. Yu, H. V. Meier, A. Afshar, K. Golts, E. Lin, G. Y. Castaldi, A. Calvert, B. Ryan, A. Zhou, B. Offringa, I. Marconett, C. N. Borok, Z. 2024-04-12 doi:10.1101/2024.04.05.588292 Cold Spring Harbor Laboratory Press 2024-04-12 <![CDATA[ Delivering large genes using adeno-associated virus and the CRE-lox DNA recombination system ]]> https://biorxiv.org/content/10.1101/2024.04.10.588864v1?rss=1 Datta, P. Rhee, K. D. Staudt, R. J. Thompson, J. M. Hsu, Y. Hassan, S. Drack, A. V. Seo, S. 2024-04-10 doi:10.1101/2024.04.10.588864 Cold Spring Harbor Laboratory Press 2024-04-10 <![CDATA[ Regulation of lung cancer initiation and progression by the stem cell determinant Musashi ]]> https://biorxiv.org/content/10.1101/2024.04.11.589053v1?rss=1 Barber, A. G. Quintero, C. M. Hamilton, M. Rajbhandari, N. Sasik, R. Zhang, Y. Kim, C. Husain, H. Sun, X. Reya, T. 2024-04-15 doi:10.1101/2024.04.11.589053 Cold Spring Harbor Laboratory Press 2024-04-15 <![CDATA[ Insulated piggyBac and FRT vectors for engineering transgenic homozygous and heterozygous eHAP cells ]]> https://biorxiv.org/content/10.1101/2024.04.19.590353v1?rss=1 Minard, A. Y. Winistorfer, S. Piper, R. C. 2024-04-23 doi:10.1101/2024.04.19.590353 Cold Spring Harbor Laboratory Press 2024-04-23 <![CDATA[ Evolution of a Eukaryotic Transcription Factor's co-TF Dependence Involves Multiple Intrinsically Disordered Regions Affecting Activation and Autoinhibition ]]> https://biorxiv.org/content/10.1101/2024.04.20.590343v1?rss=1 Snyder, L. F. O'Brien, E. M. Zhao, J. Liang, J. Zhang, Y. Zhu, W. Cassier, T. Schnicker, N. J. Zhou, X. Gordan, R. He, B. Z. 2024-04-24 doi:10.1101/2024.04.20.590343 Cold Spring Harbor Laboratory Press 2024-04-24 <![CDATA[ Biochemical Impact of p300-Mediated Acetylation of Replication Protein A: Implications for DNA Metabolic Pathway Choice ]]> https://biorxiv.org/content/10.1101/2024.04.22.590612v1?rss=1 Ononye, O. E. Surendran, S. Howald, O. K. Petrides, A. K. Jordan, M. R. Ainembabazi, D. Wold, M. S. Turchi, J. J. Balakrishnan, L. 2024-04-23 doi:10.1101/2024.04.22.590612 Cold Spring Harbor Laboratory Press 2024-04-23 <![CDATA[ HSD2 neurons are evolutionarily conserved and required for aldosterone-induced salt appetite ]]> https://biorxiv.org/content/10.1101/2024.04.24.590990v1?rss=1 Gasparini, S. Peltekian, L. McDonough, M. C. Mitchell, C. J. A. Hefti, M. M. Resch, J. M. Geerling, J. C. 2024-04-28 doi:10.1101/2024.04.24.590990 Cold Spring Harbor Laboratory Press 2024-04-28 <![CDATA[ Global mapping of the Chlamydia trachomatis conventional secreted effector-host interactome reveals CebN interacts with nucleoporins and Rae1 to impede STAT1 nuclear translocation. ]]> https://biorxiv.org/content/10.1101/2024.04.25.587017v1?rss=1 Steiert, B. Andersen, S. E. McCaslin, P. N. Elwell, C. A. Faris, R. Tijerina, X. Smith, P. Eldridge, Q. Imai, B. S. Arrington, J. V. Yau, P. M. Mirrashidi, K. M. Johnson, J. R. Verschueren, E. Von Dollen, J. Jang, G. M. Krogan, N. J. Engel, J. N. Weber, M. M. 2024-04-26 doi:10.1101/2024.04.25.587017 Cold Spring Harbor Laboratory Press 2024-04-26 <![CDATA[ Generation and validation of a D1 dopamine receptor Flpo knock-in mouse ]]> https://biorxiv.org/content/10.1101/2024.04.25.591164v1?rss=1 Oppman, A. M. Paradee, W. J. Narayanan, N. S. Kim, Y.-c. 2024-04-28 doi:10.1101/2024.04.25.591164 Cold Spring Harbor Laboratory Press 2024-04-28 <![CDATA[ Cell-type-specific fluorescent tagging of endogenous target proteins reveals synaptic enrichment and dynamic regulations of dopamine receptors ]]> https://biorxiv.org/content/10.1101/2024.04.29.591637v1?rss=1 Hiramatsu, S. Saito, K. Kondo, S. Katow, H. Yamagata, N. Wu, C.-F. Tanimoto, H. 2024-04-30 doi:10.1101/2024.04.29.591637 Cold Spring Harbor Laboratory Press 2024-04-30 <![CDATA[ Gammaherpesvirus infection triggers the formation of tRNA fragments from premature tRNAs ]]> https://biorxiv.org/content/10.1101/2024.05.01.592122v1?rss=1 Manning, A. C. Bashir, M. M. Jimenez, A. R. Upton, H. Collins, K. Lowe, T. M. Tucker, J. M. 2024-05-02 doi:10.1101/2024.05.01.592122 Cold Spring Harbor Laboratory Press 2024-05-02 <![CDATA[ Device-free isolation of photoreceptor cells from patient iPSC-derived retinal organoids ]]> https://biorxiv.org/content/10.1101/2024.05.02.592255v1?rss=1 Stone, N. E. Bohrer, L. R. Mullin, N. K. Cooke, J. Wright, A. T. Stone, E. M. Mullins, R. F. Tucker, B. A. 2024-05-05 doi:10.1101/2024.05.02.592255 Cold Spring Harbor Laboratory Press 2024-05-05 <![CDATA[ The role of Med15 sequence features in transcription factor interactions ]]> https://biorxiv.org/content/10.1101/2024.05.04.592524v1?rss=1 Cooper, D. G. Liu, S. Grunkemeyer, E. Fassler, J. S. 2024-05-05 doi:10.1101/2024.05.04.592524 Cold Spring Harbor Laboratory Press 2024-05-05 <![CDATA[ Differential effects of PDE4A5 on cAMP-dependent forms of long-term potentiation ]]> https://biorxiv.org/content/10.1101/2024.05.04.592525v1?rss=1 View larger version (53K): org.highwire.dtl.DTLVardef@1ee4ccdorg.highwire.dtl.DTLVardef@1f43c3corg.highwire.dtl.DTLVardef@19eb64dorg.highwire.dtl.DTLVardef@d2bab0_HPS_FORMAT_FIGEXP M_FIG GRAPHICAL ABSTRACT Spaced tetanic stimulation and TBS induce cAMP synthesis and activation of PKA to promote signaling cascades that facilitate expression of long-lasting LTP at the CA3-CA1 synapses. PDE4A5 overexpression in the hippocampus selectively impairs cAMP and PKA dependent TBS-LTP at the CA3-CA1 synapses, while sparing LTP induced by spaced tetanization. C_FIG ]]> Tadinada, S. M. Mukherjee, U. Walsh, E. N. Abel, T. 2024-05-07 doi:10.1101/2024.05.04.592525 Cold Spring Harbor Laboratory Press 2024-05-07 <![CDATA[ Exonic splice variant discovery using in vitro models of inherited retinal disease ]]> https://biorxiv.org/content/10.1101/2024.05.06.592740v1?rss=1 A (p.Arg311Gln) is a variant commonly associated with Enhanced S Cone Syndrome (ESCS). Previous studies using mutagenized cDNA constructs have shown that the arginine to glutamine substitution at position 311 of NR2E3 does not meaningfully diminish function of the rod-specific transcription factor. Using retinal organoids, we explored the molecular consequences of NR2E3 c.932G>A when expressed endogenously during human rod photoreceptor cell development. Retinal organoids carrying the NR2E3 c.932G>A allele expressed a transcript containing a 186-nucleotide deletion of exon 6 within the ligand binding domain. This short transcript was not detected in control organoids or control human donor retina samples. A minigene containing exons 5 and 6 of NR2E3 showed sufficiency of the c.932G>A variant to cause the observed splicing defect. These results support the hypothesis that the pathogenic NR2E3 c.932G>A variant leads to photoreceptor disease by causing a splice defect and not through an amino acid substitution as previously supposed. They also explain the relatively mild effect of Arg311Gln on NR2E3 function in vitro. We also used in silico prediction tools to show that similar changes are likely to affect other inherited retinal disease variants in genes such as CEP290, ABCA4, and BEST1. ]]> Mullin, N. K. Bohrer, L. R. Anfinson, K. R. Andorf, J. L. Mullins, R. F. Tucker, B. A. Stone, E. M. 2024-05-10 doi:10.1101/2024.05.06.592740 Cold Spring Harbor Laboratory Press 2024-05-10 <![CDATA[ Mechanical activation of VE-cadherin stimulates AMPK to increase endothelial cell metabolism and vasodilation ]]> https://biorxiv.org/content/10.1101/2024.05.09.593171v1?rss=1 Wells, N. Dawson, L. DeMali, K. A. 2024-05-13 doi:10.1101/2024.05.09.593171 Cold Spring Harbor Laboratory Press 2024-05-13 <![CDATA[ Perivascular adipose tissue remodeling impairs vasoreactivity in thermoneutral-housed rats ]]> https://biorxiv.org/content/10.1101/2024.05.09.593330v1?rss=1 Henckel, M. Chun, J. H. Knaub, L. Pott, G. James, G. Hunter, K. Shandas, R. Walker, L. Reusch, J. Keller, A. 2024-05-13 doi:10.1101/2024.05.09.593330 Cold Spring Harbor Laboratory Press 2024-05-13 <![CDATA[ Development of a humanized anti-FABP4 monoclonal antibody for treatment of breast cancer ]]> https://biorxiv.org/content/10.1101/2024.05.12.593748v1?rss=1 Hao, J. Jin, R. Yi, Y. Jiang, X. Yu, J. Xu, Z. Schnicker, N. J. Chimenti, M. S. Sugg, S. L. Li, B. 2024-05-14 doi:10.1101/2024.05.12.593748 Cold Spring Harbor Laboratory Press 2024-05-14 <![CDATA[ Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells. ]]> https://biorxiv.org/content/10.1101/2024.05.13.593567v1?rss=1 Haight, J. Koppenhafer, S. Geary, E. Gordon, D. 2024-05-15 doi:10.1101/2024.05.13.593567 Cold Spring Harbor Laboratory Press 2024-05-15 <![CDATA[ Magnetically Steered Cell Therapy For Functional Restoration Of Intraocular Pressure Control In Open-Angle Glaucoma ]]> https://biorxiv.org/content/10.1101/2024.05.13.593917v1?rss=1 Bahrani Fard, M. R. Chan, J. Read, A. T. Li, G. Cheng, L. N Safa, B. Siadat, S. M. Jhunjhunwala, A. Grossniklaus, H. E. Emelianov, S. Y. Stamer, W. D. Kuehn, M. H. Ethier, C. R. 2024-05-15 doi:10.1101/2024.05.13.593917 Cold Spring Harbor Laboratory Press 2024-05-15 <![CDATA[ FtsN coordinates septal peptidoglycan synthesis and degradation through self-interaction of SPOR in E. coli ]]> https://biorxiv.org/content/10.1101/2024.05.13.594014v1?rss=1 Lyu, Z. Yang, X. Yahashiri, A. Ha, S. McCausland, J. W. Britton, B. M. Weiss, D. S. Xiao, J. 2024-05-13 doi:10.1101/2024.05.13.594014 Cold Spring Harbor Laboratory Press 2024-05-13 <![CDATA[ A chromosome region linked to neurodevelopmental disorders acts in distinct neuronal circuits in males and females to control locomotor behavior ]]> https://biorxiv.org/content/10.1101/2024.05.17.594746v1?rss=1 View larger version (52K): org.highwire.dtl.DTLVardef@19542baorg.highwire.dtl.DTLVardef@4ff570org.highwire.dtl.DTLVardef@17aa1c3org.highwire.dtl.DTLVardef@123e48_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Kim, J. Vanrobaeys, Y. Davatolhagh, F. kelvington, b. Chatterjee, S. Ferri, S. L. Angelakos, C. Mills, A. A. Fuccillo, M. V. nickl-Jockschat, T. Abel, T. 2024-05-17 doi:10.1101/2024.05.17.594746 Cold Spring Harbor Laboratory Press 2024-05-17 <![CDATA[ Cardioprotection by Poloxamer 188 is Mediated through Increased Endothelial Nitric Oxide Production ]]> https://biorxiv.org/content/10.1101/2024.05.18.593838v1?rss=1 Chen, G. Douglas, H. F. Li, Z. Cleveland, W. J. Balzer, C. Yannopolous, D. Chen, I. Y.-L. Obal, D. Riess, M. L. 2024-05-20 doi:10.1101/2024.05.18.593838 Cold Spring Harbor Laboratory Press 2024-05-20 <![CDATA[ Human Breast Milk EVs Mitigate Endothelial Dysfunction: Preliminary Study ]]> https://biorxiv.org/content/10.1101/2024.05.20.594769v1?rss=1 Cho, Y.-E. Chen, S. Shutt, D. Kaufman, J. Singh, B. 2024-05-21 doi:10.1101/2024.05.20.594769 Cold Spring Harbor Laboratory Press 2024-05-21 <![CDATA[ SARS-CoV-2 infection unevenly impacts metabolism in the coronal periphery of the lungs ]]> https://biorxiv.org/content/10.1101/2024.05.22.595414v1?rss=1 Laro, J. A. Xue, B. Zheng, J. Ness, M. Perlman, S. McCall, L.-I. 2024-05-23 doi:10.1101/2024.05.22.595414 Cold Spring Harbor Laboratory Press 2024-05-23 <![CDATA[ Mucociliary Clearance is Impaired in Small Airways of Cystic Fibrosis Pigs ]]> https://biorxiv.org/content/10.1101/2024.05.22.595427v1?rss=1 Stewart, C. G. Hilkin, B. M. Gansemer, N. D. Dick, D. W. Sunderland, J. J. Stoltz, D. A. Abou Alaiwa, M. H. Zabner, J. 2024-05-25 doi:10.1101/2024.05.22.595427 Cold Spring Harbor Laboratory Press 2024-05-25 <![CDATA[ Overlapping coactivator function is required for transcriptional activation by the Candida glabrata Pdr1 transcription factor ]]> https://biorxiv.org/content/10.1101/2024.05.24.595833v1?rss=1 Conway, T. P. Simonicova, L. Moye-Rowley, W. S. 2024-05-30 doi:10.1101/2024.05.24.595833 Cold Spring Harbor Laboratory Press 2024-05-30 <![CDATA[ Activation of Heme Metabolism Promotes Tissue Health after Intraarticular Injury or Surgical Exposure ]]> https://biorxiv.org/content/10.1101/2024.05.29.596521v1?rss=1 Liman, S. Gomez-Contreras, P. C. Hines, M. R. Fisher, J. S. Lu, K. J. McNally, L. D. Sakyi, M. Y. Wagner, B. A. Goetz, J. E. Byrne, J. D. Coleman, M. C. 2024-05-30 doi:10.1101/2024.05.29.596521 Cold Spring Harbor Laboratory Press 2024-05-30 <![CDATA[ Mitoregulin supports mitochondrial membrane integrity and protects against cardiac ischemia-reperfusion injury ]]> https://biorxiv.org/content/10.1101/2024.05.31.596875v1?rss=1 Stein, C. S. Zhang, X. Witmer, N. H. Pennington, E. R. Shaikh, S. R. Boudreau, R. L. 2024-06-01 doi:10.1101/2024.05.31.596875 Cold Spring Harbor Laboratory Press 2024-06-01 <![CDATA[ Two non-coding variants associated with isolated orofacial cleft promote binding of transcriptional repressors FOXE1 or ETS2 and reduce expression of IRF6 ]]> https://biorxiv.org/content/10.1101/2024.06.01.596914v1?rss=1 Kumari, P. Friedman, R. Z. Pi, L. Curtis, S. Paraiso, K. Visel, A. Rhea, L. Dunnwald, M. Patni, A. P. Mar, D. Bomsztyk, K. Mathieu, J. Ruohola-Baker, H. Leslie, E. White, M. A. Cohen, B. A. Cornell, R. A. 2024-06-03 doi:10.1101/2024.06.01.596914 Cold Spring Harbor Laboratory Press 2024-06-03 <![CDATA[ Development of self-healing hydrogels to support choroidal endothelial cell transplantation for the treatment of early age related macular degeneration ]]> https://biorxiv.org/content/10.1101/2024.06.07.597936v1?rss=1 Pandala, N. Han, I. C. Tobin, K. Brogden, N. K. Mulfaul, K. Mullins, R. Tucker, B. A. 2024-06-09 doi:10.1101/2024.06.07.597936 Cold Spring Harbor Laboratory Press 2024-06-09 <![CDATA[ Adjuvant Delivery Method and Nanoparticle Charge Influence Peptide Amphiphile Micelle Vaccine Bioactivity ]]> https://biorxiv.org/content/10.1101/2024.06.10.598369v1?rss=1 Zhang, R. Rygelski, B. T. Kruse, L. E. Smith, J. D. Wang, X. Allen, B. N. Kramer, J. S. Seim, G. F. Faulkner, T. J. Schrum, A. G. Ulery, B. D. 2024-06-12 doi:10.1101/2024.06.10.598369 Cold Spring Harbor Laboratory Press 2024-06-12 <![CDATA[ Early transatlantic movement of horses and donkeys at Jamestown ]]> https://biorxiv.org/content/10.1101/2024.06.11.598569v1?rss=1 Taylor, W. T. T. Delsol, N. Oelze, V. M. Mitchell, P. Stricker, L. Lavin, M. Ogundiran, A. Hosek, L. Barron-Ortiz, C. I. Ojediran, O. Quintero-Bisono, D. Magoon, D. Hill, M. E. Thomas, A. E. Waterman, A. Peate, D. W. Chauvey, L. Schiavinato, S. Tonasso-Calviere, L. Borges, L. Brito-Mayor, A. Santana, J. Kamenov, G. Orlando, L. Krigbaum, J. 2024-06-15 doi:10.1101/2024.06.11.598569 Cold Spring Harbor Laboratory Press 2024-06-15 <![CDATA[ Airway basal stem cells are necessary for the maintenance of functional intraepithelial airway macrophages. ]]> https://biorxiv.org/content/10.1101/2024.06.25.600501v1?rss=1 Kooistra, T. Saez, B. Roche, M. Egea-Zorrilla, A. Li, D. Anketell, D. Nguyen, N. Villoria, J. Gillis, J. Petri, E. Vera, L. Smith, N. P. Alladina, J. Zhang, Y. Vinarsky, V. Shivaraju, M. Sheng, S. L. Gonzalez-Celeiro, M. Mou, H. Waghray, A. Lin, B. Paksa, A. Yanger, K. Tata, P. R. Zhao, R. Causton, B. Zulueta, J. Prosper, F. Cho, J. L. Villani, A.-C. Haber, A. Rajagopal, J. Medoff, B. D. Pardo-Saganta, A. 2024-06-26 doi:10.1101/2024.06.25.600501 Cold Spring Harbor Laboratory Press 2024-06-26 <![CDATA[ A widespread electrical brain network encodes anxiety in health and depressive states ]]> https://biorxiv.org/content/10.1101/2024.06.26.600900v1?rss=1 Hughes, D. N. Klein, M. H. Walder-Christensen, K. K. Thomas, G. E. Grossman, Y. Waters, D. Matthews, A. E. Carson, W. E. Filali, Y. Tsyglakova, M. Fink, A. Gallagher, N. M. Perez-Balaguer, M. McClung, C. A. Zarate, J. M. Hultman, R. C. Mague, S. D. Carlson, D. Dzirasa, K. 2024-06-30 doi:10.1101/2024.06.26.600900 Cold Spring Harbor Laboratory Press 2024-06-30 <![CDATA[ FABP4-mediated lipid accumulation and lipolysis in tumor associated macrophages promote breast cancer metastasis ]]> https://biorxiv.org/content/10.1101/2024.07.02.601733v1?rss=1 View larger version (57K): org.highwire.dtl.DTLVardef@7cba6dorg.highwire.dtl.DTLVardef@b37fb2org.highwire.dtl.DTLVardef@84aa8forg.highwire.dtl.DTLVardef@1d9bda2_HPS_FORMAT_FIGEXP M_FIG C_FIG HighlightsO_LIUnlike saturated fatty acids, unsaturated fatty acids preferentially promote lipid droplet formation in macrophages. 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A. 2024-07-04 doi:10.1101/2024.07.03.601941 Cold Spring Harbor Laboratory Press 2024-07-04 <![CDATA[ Sexually dimorphic auditory representation in Aedes aegypti brains ]]> https://biorxiv.org/content/10.1101/2024.07.07.602439v1?rss=1 Ohashi, T. S. Xu, Y. Y. J. Shigaki, S. Nakamura, Y. Lee, T.-T. Loh, Y. M. Mishiro-Sato, E. Eberl, D. F. Su, M. P. Kamikouchi, A. 2024-07-10 doi:10.1101/2024.07.07.602439 Cold Spring Harbor Laboratory Press 2024-07-10 <![CDATA[ Mitoregulin self-associates to form likely homo-oligomeric pore-like structures ]]> https://biorxiv.org/content/10.1101/2024.07.10.601956v1?rss=1 Linzer, C. R. Stein, C. S. Witmer, N. H. Xu, Z. Schnicker, N. J. Boudreau, R. L. 2024-07-11 doi:10.1101/2024.07.10.601956 Cold Spring Harbor Laboratory Press 2024-07-11 <![CDATA[ Determining potential immunomodulatory drug efficacy in sepsis using ELISpot ]]> https://biorxiv.org/content/10.1101/2024.07.10.602970v1?rss=1 Walton, A. H. Mazer, M. B. Remy, K. E. Davitt, E. B. Griffith, T. S. Gould, R. W. Badovinac, V. P. Brakenridge, S. C. Drewry, A. M. Loftus, T. J. Efron, P. A. Moldawer, L. L. Caldwell, C. C. Hotchkiss, R. S. 2024-07-16 doi:10.1101/2024.07.10.602970 Cold Spring Harbor Laboratory Press 2024-07-16 <![CDATA[ A wavelet-based approach generates quantitative, scale-free and hierarchical descriptions of 3D genome structures and new biological insights ]]> https://biorxiv.org/content/10.1101/2024.07.12.603291v1?rss=1 Pellow, R. Comeron, J. M. 2024-07-16 doi:10.1101/2024.07.12.603291 Cold Spring Harbor Laboratory Press 2024-07-16 <![CDATA[ Multiple dermal cell types support productive infection and dynamic translocation of infectious Ebola virus to the apical surface of human skin ]]> https://biorxiv.org/content/10.1101/2024.07.19.604135v1?rss=1 Messingham, K. Richards, P. T. Fleck, A. Patel, R. A. Djurkovic, M. Elliff, J. Connell, S. Gonzalez, J. P. M. Gourronc, F. A. Dillard, J. A. Davey, R. A. Klingelhutz, A. J. Shtanko, O. Maury, W. 2024-07-19 doi:10.1101/2024.07.19.604135 Cold Spring Harbor Laboratory Press 2024-07-19 <![CDATA[ Effects of Age and Diet on Triglyceride Metabolism in Mice ]]> https://biorxiv.org/content/10.1101/2024.07.19.602944v1?rss=1 Spitler, K. M. Shetty, S. K. Davies, B. S. 2024-07-22 doi:10.1101/2024.07.19.602944 Cold Spring Harbor Laboratory Press 2024-07-22 <![CDATA[ Supervised Automation of Cell Counting in Confocal Microscopic Cochlear Imaging Datasets Using Macro in Imaris ]]> https://biorxiv.org/content/10.1101/2024.07.24.604970v1?rss=1 View larger version (64K): org.highwire.dtl.DTLVardef@11b4aa0org.highwire.dtl.DTLVardef@c08c7dorg.highwire.dtl.DTLVardef@1479b59org.highwire.dtl.DTLVardef@280227_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Rahman, M. T. Khan, N. A. Mokbul, M. I. Razu, I. Fatima, S. M. Lira, S. S. Garcia, C. Eckard, P. Hansen, M. R. 2024-07-24 doi:10.1101/2024.07.24.604970 Cold Spring Harbor Laboratory Press 2024-07-24 <![CDATA[ Iowa Brain-Behavior Modeling Toolkit: An Open-Source MATLAB Tool for Inferential and Predictive Modeling of Imaging-Behavior and Lesion-Deficit Relationships ]]> https://biorxiv.org/content/10.1101/2024.07.31.606046v1?rss=1 Griffis, J. C. Bruss, J. Acker, S. F. Shea, C. Tranel, D. Boes, A. D. 2024-08-01 doi:10.1101/2024.07.31.606046 Cold Spring Harbor Laboratory Press 2024-08-01 <![CDATA[ Thermodynamic modeling of Csr/Rsm- RNA interactions capture novel, direct binding interactions across the Pseudomonas aeruginosa transcriptome ]]> https://biorxiv.org/content/10.1101/2024.08.01.606018v1?rss=1 Lukasiewicz, A. J. Leistra, A. N. Hoefner, L. Monzon, E. Gode, C. J. Zorn, B. T. Janssen, K. H. Yahr, T. L. Wolfgang, M. C. Contreras, L. M. 2024-08-02 doi:10.1101/2024.08.01.606018 Cold Spring Harbor Laboratory Press 2024-08-02 <![CDATA[ Modeling glioblastoma tumor progression via CRISPR-engineered brain organoids ]]> https://biorxiv.org/content/10.1101/2024.08.02.606387v1?rss=1 Ishahak, M. Han, R. H. Annamalai, D. Woodiwiss, T. McCornack, C. Cleary, R. T. DeSouza, P. A. Qu, X. Dahiya, S. Kim, A. H. Millman, J. R. 2024-08-03 doi:10.1101/2024.08.02.606387 Cold Spring Harbor Laboratory Press 2024-08-03 <![CDATA[ Nonlinear thinking in ecology and evolution: The case for ecological scaling of the Threshold Elemental Ratio ]]> https://biorxiv.org/content/10.1101/2024.08.20.608290v1?rss=1 Tumolo, B. Olson, C. Larson, E. Halvorson, H. Wagner, C. E. Krist, A. Osburn, F. Moody, E. Rock, L. Ogbenna, U. Wess, E. Najev, B. L. Pignatelli, A. Corman, J. 2024-08-21 doi:10.1101/2024.08.20.608290 Cold Spring Harbor Laboratory Press 2024-08-21 <![CDATA[ Phthalate exposure influences mating behavior and sperm morphology in an aquatic ecotoxicology model system ]]> https://biorxiv.org/content/10.1101/2024.08.20.608834v1?rss=1 Guevara, B. L. Patel, N. Tu, Y. Neiman, M. 2024-08-21 doi:10.1101/2024.08.20.608834 Cold Spring Harbor Laboratory Press 2024-08-21 <![CDATA[ Simultaneous GCaMP imaging and focal recording of tonic and phasic synapses: Probing short-term plasticity within a defined microenvironment ]]> https://biorxiv.org/content/10.1101/2024.08.25.609565v1?rss=1 Xing, X. Wu, C.-F. 2024-08-26 doi:10.1101/2024.08.25.609565 Cold Spring Harbor Laboratory Press 2024-08-26 <![CDATA[ Nuclear actin is a critical regulator of Drosophila female germline stem cell maintenance ]]> https://biorxiv.org/content/10.1101/2024.08.27.609996v1?rss=1 Green, N. M. Talbot, D. E. Tootle, T. L. 2024-08-28 doi:10.1101/2024.08.27.609996 Cold Spring Harbor Laboratory Press 2024-08-28 <![CDATA[ Brain Charts for the Rhesus Macaque Lifespan ]]> https://biorxiv.org/content/10.1101/2024.08.28.610193v1?rss=1 Alldritt, S. Ramirez, J. S. B. Vos de Wael, R. Bethlehem, R. Seidlitz, J. Wang, Z. Nenning, K.-H. Esper, N. B. Smallwood, J. Franco, A. R. Byeon, K. Alexander-Bloch, A. Messinger, A. Chen, A. Thiele, A. Weiss, A. R. Shmuel, A. Fox, A. Tusche, A. Brambrink, A. M. Falchier, A. Hiba, B. Jarraya, B. Jung, B. Butler, B. Russ, B. E. Howell, B. R. Drzewiecki, C. M. Guedj, C. Schwiedrzik, C. M. Amiez, C. Wilson, C. R. E. Klink, C. Kroenke, C. Constantinidis, C. Garin, C. M. Poirier, C. Gale, D. J. Leopold, D. A. Rudko, D. A. Amaral, D. G. Tsao, D. Cook, D. J. 2024-08-30 doi:10.1101/2024.08.28.610193 Cold Spring Harbor Laboratory Press 2024-08-30 <![CDATA[ Emergent metabolic interactions in resistance to Clostridioides difficile invasion ]]> https://biorxiv.org/content/10.1101/2024.08.29.610284v1?rss=1 Ambat, A. van den Berg, N. I. Zorrilla, F. Menon, S. Maji, A. Basile, A. Ghimire, S. Kalmar, L. Patil, K. R. Scaria, J. 2024-08-30 doi:10.1101/2024.08.29.610284 Cold Spring Harbor Laboratory Press 2024-08-30 <![CDATA[ Analogues of the anti-malaria drug mefloquine have broad spectrum antifungal activity and are efficacious in a model of disseminated Candida auris infection. ]]> https://biorxiv.org/content/10.1101/2024.08.29.610379v1?rss=1 Guin, S. montoya, m. wang, X. Zarnowski, R. Andes, D. R. Meyers, M. J. Williams, N. Krysan, D. J. 2024-08-30 doi:10.1101/2024.08.29.610379 Cold Spring Harbor Laboratory Press 2024-08-30 <![CDATA[ Proteomic Investigation of Neurotrophic trans-Banglene Reveals Potential Link to Iron Homeostasis ]]> https://biorxiv.org/content/10.1101/2024.09.04.611284v1?rss=1 Gunawardana, P. W. Gohil, K. Moon, K.-M. Foster, L. J. Williams, F. J. 2024-09-04 doi:10.1101/2024.09.04.611284 Cold Spring Harbor Laboratory Press 2024-09-04 <![CDATA[ Culture Conditions Differentially Regulate the Inflammatory Niche and Cellular Phenotype of Tracheo-Bronchial Basal Stem Cells ]]> https://biorxiv.org/content/10.1101/2024.09.04.611264v1?rss=1 Murthy, S. Seabold, D. A. Gautam, L. K. Caceres, A. M. Sease, R. Calvert, B. A. Busch, S. Neely, A. Marconett, C. N. Ryan, A. L. 2024-09-05 doi:10.1101/2024.09.04.611264 Cold Spring Harbor Laboratory Press 2024-09-05 <![CDATA[ Conserved role of spike S2 domain N-glycosylation across beta-coronavirus family ]]> https://biorxiv.org/content/10.1101/2024.09.05.611372v1?rss=1 Yang, Q. Kelkar, A. Manicassamy, B. Neelamegham, S. 2024-09-05 doi:10.1101/2024.09.05.611372 Cold Spring Harbor Laboratory Press 2024-09-05 <![CDATA[ Targeting CXCR4 with -Pentixather Significantly Increases Overall Survival in Small Cell Lung Cancer ]]> https://biorxiv.org/content/10.1101/2024.09.06.611663v1?rss=1 Christensen, K. A. Fath, M. A. Ewald, J. T. Robles-Planells, C. Graves, S. A. Johnson, S. S. Zacharias, Z. R. Houtman, J. C. D. O'Dorisio, M. S. Schultz, M. K. Allen, B. G. Furqan, M. Menda, Y. Liu, D. Spitz, D. R. 2024-09-11 doi:10.1101/2024.09.06.611663 Cold Spring Harbor Laboratory Press 2024-09-11 <![CDATA[ Predicting speech-in-noise ability with static and dynamic auditory figure-ground analysis using structural equation modelling ]]> https://biorxiv.org/content/10.1101/2024.09.08.611859v1?rss=1 Guo, X. Benzaquen, E. Holmes, E. Berger, J. I. Brühl, I. Sedley, W. Rushton, S. Griffiths, T. 2024-09-13 doi:10.1101/2024.09.08.611859 Cold Spring Harbor Laboratory Press 2024-09-13 <![CDATA[ The mitochondrial dicarboxylate carrier mediates in vivo hepatic gluconeogenesis ]]> https://biorxiv.org/content/10.1101/2024.09.12.612761v1?rss=1 Pape, D. J. Falls-Hubert, K. C. Merrill, R. A. Ahmed, A. Qian, Q. McGivney, G. R. Sobieralski, P. Rauckhorst, A. J. Yang, L. Taylor, E. B. 2024-09-13 doi:10.1101/2024.09.12.612761 Cold Spring Harbor Laboratory Press 2024-09-13 <![CDATA[ Ongoing evolution of Middle East Respiratory Syndrome Coronavirus, Kingdom of Saudi Arabia, 2023-2024 ]]> https://biorxiv.org/content/10.1101/2024.09.12.612455v1?rss=1 Hassan, A. M. Mühlemann, B. Al-Subhi, T. L. Rodon, J. El-Kafrawy, S. A. Memish, Z. Melchert, J. Bleicker, T. Mauno, T. Perlman, S. Zumla, A. Jones, T. C. Müller, M. A. Corman, V. M. Drosten, C. Azhar, E. I. 2024-09-14 doi:10.1101/2024.09.12.612455 Cold Spring Harbor Laboratory Press 2024-09-14 <![CDATA[ CelloType: A Unified Model for Segmentation and Classification of Tissue Images ]]> https://biorxiv.org/content/10.1101/2024.09.15.613139v1?rss=1 Pang, M. Roy, T. K. Wu, X. Tan, K. 2024-09-19 doi:10.1101/2024.09.15.613139 Cold Spring Harbor Laboratory Press 2024-09-19 <![CDATA[ Similarities and distinctions in the activation of the Candida glabrata Pdr1 regulatory pathway by azole and non-azole drugs ]]> https://biorxiv.org/content/10.1101/2024.09.19.613905v1?rss=1 Conway, T. P. Vu, B. G. Beattie, S. R. Krysan, D. J. Moye-Rowley, W. S. 2024-09-19 doi:10.1101/2024.09.19.613905 Cold Spring Harbor Laboratory Press 2024-09-19 <![CDATA[ Tenascin-C in the early lung cancer tumor microenvironment promotes progression through integrin activation and FAK ]]> https://biorxiv.org/content/10.1101/2024.09.17.613509v1?rss=1 Mendoza, M. C. Samson, S. C. Rojas, A. Zitnay, R. G. Carney, K. R. Hettinga, W. Shaelling, M. C. Sicard, D. Zhang, W. Gilbert-Ross, M. Dy, G. K. Cavnar, M. J. Furqan, M. Browning, R. F. Naqash, A. R. Schneider, B. P. Tarhini, A. Tschumperlin, D. J. Venosa, A. Marcus, A. I. Emerson, L. L. Spike, B. T. Knudsen, B. 2024-09-21 doi:10.1101/2024.09.17.613509 Cold Spring Harbor Laboratory Press 2024-09-21 <![CDATA[ Lysosomal LRRC8 complex regulates lysosomal pH, morphology and systemic glucose metabolism ]]> https://biorxiv.org/content/10.1101/2024.09.22.614256v1?rss=1 Kumar, A. Zhao, Y. Xie, L. Chadda, R. Abraham, N. Hong, J. Feng, E. Tranter, J. D. Rawnsley, D. Liu, H. Henry, K. M. Meyer, G. Hu, M. Xu, H. Hinton, A. Grueter, C. E. Abel, E. D. Norris, A. W. Diwan, A. Sah, R. 2024-09-23 doi:10.1101/2024.09.22.614256 Cold Spring Harbor Laboratory Press 2024-09-23 <![CDATA[ Challenges and advances for huntingtin detection in cerebrospinal fluid: in support of relative quantification ]]> https://biorxiv.org/content/10.1101/2024.09.25.614766v1?rss=1 Harding, R. J. Xie, Y. Caron, N. S. J. Findlay-Black, H. Lyu, C. Potluri, N. Chandrasekaran, R. Hayden, M. R. Leavitt, B. R. Langbehn, D. Southwell, A. 2024-09-27 doi:10.1101/2024.09.25.614766 Cold Spring Harbor Laboratory Press 2024-09-27 <![CDATA[ Amphetamine increases timing variability by degrading prefrontal ramping activity ]]> https://biorxiv.org/content/10.1101/2024.09.26.615252v1?rss=1 Weber, M. A. Sivakumar, K. Kirkpatrick, B. Q. Stutt, H. R. Tabakovic, E. E. Bova, A. S. Kim, Y.-c. Narayanan, N. S. 2024-09-29 doi:10.1101/2024.09.26.615252 Cold Spring Harbor Laboratory Press 2024-09-29 <![CDATA[ LPS-induced delirium-like behavior and microglial activation in mice correlate with bispectral electroencephalography (BSEEG) ]]> https://biorxiv.org/content/10.1101/2024.09.27.615556v1?rss=1 Nishiguchi, T. Yamanishi, K. Gorantla, N. Shimura, A. Seki, T. Ishii, T. Aoyama, B. Malicoat, J. R. Phuong, N. J. Dye, N. J. Yamanashi, T. Iwata, M. Shinozaki, G. 2024-09-30 doi:10.1101/2024.09.27.615556 Cold Spring Harbor Laboratory Press 2024-09-30 <![CDATA[ An unprecedented small RNA-riboswitch interaction controls expression of a bifunctional pump that is essential for Staphylococcus aureus infection ]]> https://biorxiv.org/content/10.1101/2024.09.30.615890v1?rss=1 Gonzalez-Espinoza, G. Prevost, K. Hussain, F. Radin, J. N. Valle, C. D. V. Maucotel, J. Barroso, M. V. Marteyn, B. S. Masse, E. Romby, P. Kehl-Fie, T. E. Georg, J. Lalaouna, D. 2024-09-30 doi:10.1101/2024.09.30.615890 Cold Spring Harbor Laboratory Press 2024-09-30 <![CDATA[ Expression Profiles of FABP4 and FABP5 in Breast Cancer: Clinical Implications and Perspectives ]]> https://biorxiv.org/content/10.1101/2024.10.01.616073v1?rss=1 Li, B. 2024-10-02 doi:10.1101/2024.10.01.616073 Cold Spring Harbor Laboratory Press 2024-10-02 <![CDATA[ Gene-by-environment interactions and adaptive body size variation in mice from the Americas ]]> https://biorxiv.org/content/10.1101/2024.10.03.616282v1?rss=1 Mack, K. L. Landino, N. P. Tertyshnaia, M. Longo, T. C. Vera, S. A. Crew, L. A. McDonald, K. Phifer-Rixey, M. 2024-10-03 doi:10.1101/2024.10.03.616282 Cold Spring Harbor Laboratory Press 2024-10-03 <![CDATA[ Artificial Intelligence's Contribution to Biomedical Literature Search: Revolutionizing or Complicating? ]]> https://biorxiv.org/content/10.1101/2024.10.07.617112v1?rss=1 Yip, R. Sun, Y. J. Bassuk, A. Mahajan, V. B. 2024-10-08 doi:10.1101/2024.10.07.617112 Cold Spring Harbor Laboratory Press 2024-10-08 <![CDATA[ Cannabinoids shift the basal ganglia miRNA m6A methylation profile towards an anti-inflammatory phenotype in SIV-infected Rhesus macaques ]]> https://biorxiv.org/content/10.1101/2024.10.11.614514v1?rss=1 Okeoma, C. M. Premadasa, L. Tan, C. S. Ghiran, I. Mohan, M. 2024-10-12 doi:10.1101/2024.10.11.614514 Cold Spring Harbor Laboratory Press 2024-10-12 <![CDATA[ Identification of SLC35A1 as an essential host factor for the transduction of multi-serotype recombinant adeno-associated virus (AAV) vectors ]]> https://biorxiv.org/content/10.1101/2024.10.16.618764v1?rss=1 Zhang, X. Hao, S. Feng, Z. Ning, K. Kuz, C. A. McFarlin, S. Richart, D. Cheng, F. Zhang-Chen, A. McFarlane, R. Yan, Z. Qiu, J. 2024-10-17 doi:10.1101/2024.10.16.618764 Cold Spring Harbor Laboratory Press 2024-10-17 <![CDATA[ Regulator of G-Protein Signaling 2 Knockout in CD4+ T Cells Promotes Anti-Inflammatory T Cells, Enhancing Ovulation, and Oocyte Yield ]]> https://biorxiv.org/content/10.1101/2024.10.15.618561v1?rss=1 Raff, M. Benton, T. Brummons, D. Kovach, D. Bunton, O. Janky, E. Scroggins, D. G. Duran, E. H. Gray, G. Scroggins, S. M. 2024-10-18 doi:10.1101/2024.10.15.618561 Cold Spring Harbor Laboratory Press 2024-10-18 <![CDATA[ Cryo-electron microscopy reveals a single domain antibody with a unique binding epitope on fibroblast activation protein alpha ]]> https://biorxiv.org/content/10.1101/2024.10.18.619146v1?rss=1 Xu, Z. Sinha, A. Pandya, D. N. Schnicker, N. J. Wadas, T. J. 2024-10-20 doi:10.1101/2024.10.18.619146 Cold Spring Harbor Laboratory Press 2024-10-20 <![CDATA[ Touchscreen response precision is sensitive to the explore/exploit tradeoff ]]> https://biorxiv.org/content/10.1101/2024.10.23.619903v1?rss=1 Mueller, D. Giglio, E. Chen, C. S. Holm, A. Ebitz, R. B. Grissom, N. M. 2024-10-23 doi:10.1101/2024.10.23.619903 Cold Spring Harbor Laboratory Press 2024-10-23 <![CDATA[ Restoring the Multiple Sclerosis Associated Imbalance of Gut Indole Metabolites Promotes Remyelination and Suppresses Neuroinflammation ]]> https://biorxiv.org/content/10.1101/2024.10.27.620437v1?rss=1 Jank, L. Singh, S. S. Lee, J. Dhukhwa, A. Siavoshi, F. Joshi, D. Minney, V. Gupta, K. Ghimire, S. Deme, P. Schoeps, V. A. Soman, K. Ladakis, D. Smith, M. Borkowski, K. Newman, J. Baranzini, S. E. Waubant, E. L. Fitzgerald, K. C. Mangalam, A. K. Haughey, N. Kornberg, M. D. Chamling, X. Calabresi, P. A. Bhargava, P. 2024-10-28 doi:10.1101/2024.10.27.620437 Cold Spring Harbor Laboratory Press 2024-10-28 <![CDATA[ Sex and Region-Specific Disruption of Autophagy and Mitophagy in Alzheimer's Disease: Linking Cellular Dysfunction to Cognitive Decline ]]> https://biorxiv.org/content/10.1101/2024.10.30.621097v1?rss=1 View larger version (31K): org.highwire.dtl.DTLVardef@1e50ceeorg.highwire.dtl.DTLVardef@b41ac0org.highwire.dtl.DTLVardef@4863d3org.highwire.dtl.DTLVardef@91b2d0_HPS_FORMAT_FIGEXP M_FIG C_FIG Graphical AbstractSex-specific differences in autophagy and mitophagy regulation in Alzheimers disease (AD) are highlighted. Female 3xTg-AD mice show autophagosome accumulation and cognitive deficits, while males exhibit variations in mitophagy markers and behavior. ]]> Adlimoghaddam, A. Fayazbakhsh, F. Mohammadi, M. Babaei, Z. Behrooz, A. B. Tabasi, F. Guan, T. Behshti, I. Aghaei, M. Klionsky, D. J. Albensi, B. C. Ghavami, S. 2024-10-31 doi:10.1101/2024.10.30.621097 Cold Spring Harbor Laboratory Press 2024-10-31 <![CDATA[ Chlamydia trachomatis TmeA promotes pedestal formation through N-WASP and TOCA-1 interactions ]]> https://biorxiv.org/content/10.1101/2024.10.31.621191v1?rss=1 McCullough, A. CA, J. Steiert, B. Faris, R. Weber, M. M. 2024-10-31 doi:10.1101/2024.10.31.621191 Cold Spring Harbor Laboratory Press 2024-10-31 <![CDATA[ Structural basis of gap-filling DNA synthesis in the nucleosome by DNA Polymerase β ]]> https://biorxiv.org/content/10.1101/2024.11.04.621902v1?rss=1 Weaver, T. M. Ryan, B. J. Thompson, S. H. Hussen, A. S. Spencer, J. J. Xu, Z. Schnicker, N. J. Freudenthal, B. D. 2024-11-04 doi:10.1101/2024.11.04.621902 Cold Spring Harbor Laboratory Press 2024-11-04 <![CDATA[ Epidermal loss of PRMT5 leads to the emergence of an atypical basal keratinocyte-like cell population and defective skin stratification ]]> https://biorxiv.org/content/10.1101/2024.11.08.620904v1?rss=1 Recka, N. M. Simons, A. Cornell, R. A. Van Otterloo, E. 2024-11-08 doi:10.1101/2024.11.08.620904 Cold Spring Harbor Laboratory Press 2024-11-08 <![CDATA[ Perilipin 5 Phosphorylation is Dispensable for Upregulation of Hepatic Lipid Metabolism Genes upon Fasting but Required for Insulin Receptor Substrate 2 Expression in Male Mice ]]> https://biorxiv.org/content/10.1101/2024.11.09.622792v1?rss=1 Bovee, C. Grandgenett, R. Trevino, M. Dutta, S. Peachee, S. Kopriva, S. Haider, F. Liu, S. Bhardwaj, G. Penniman, C. O'Neill, B. Imai, Y. 2024-11-09 doi:10.1101/2024.11.09.622792 Cold Spring Harbor Laboratory Press 2024-11-09 <![CDATA[ Acute Inhibition of Adipose Triglyceride Lipase by NG497 Dysregulates Insulin and Glucagon Secretion from Human Islets ]]> https://biorxiv.org/content/10.1101/2024.11.11.623085v1?rss=1 Kim, L. Liu, S. Richtsmeier, S. Gorniak, M. Vikram, A. Imai, Y. 2024-11-13 doi:10.1101/2024.11.11.623085 Cold Spring Harbor Laboratory Press 2024-11-13 <![CDATA[ Peripheral CGRP engages brain-wide electrical network activity of migraine ]]> https://biorxiv.org/content/10.1101/2024.11.14.622885v1?rss=1 Johnson, M. S. Eberle, M. Hultman, I. Zhang, X. Filali, Y. Hing, B. Jimenez, A. Matkovich, M. Adegboyo, A. Velamuri, R. Miller, J. Chan, K.-S. Srivastava, S. Hultman, R. 2024-11-14 doi:10.1101/2024.11.14.622885 Cold Spring Harbor Laboratory Press 2024-11-14 <![CDATA[ An animal model for autoinflammation with infantile enterocolitis ]]> https://biorxiv.org/content/10.1101/2024.11.16.623944v1?rss=1 Kang, Z. Wang, Y. Xiong, Y. Gao, J. Z. Gurung, P. Short, S. P. 2024-11-17 doi:10.1101/2024.11.16.623944 Cold Spring Harbor Laboratory Press 2024-11-17 <![CDATA[ Renovating the Barnes maze for mouse models of Dementia with STARR FIELD: A 4-day protocol that probes learning rate, retention and cognitive flexibility. ]]> https://biorxiv.org/content/10.1101/2024.11.30.625516v1?rss=1 Bertolli, A. Halhouli, O. Liu-Martinez, Y. Blaine, B. Thangavel, R. Zhang, Q. Emmons, E. Narayanan, N. Gumusoglu, S. B. Geerling, J. C. Aldridge, G. 2024-12-01 doi:10.1101/2024.11.30.625516 Cold Spring Harbor Laboratory Press 2024-12-01 <![CDATA[ Tetramer formation of CpoS facilitates Inc-Inc interactions during Chlamydia trachomatis infection ]]> https://biorxiv.org/content/10.1101/2024.12.01.621710v1?rss=1 Tijerina, X. Jabeena, C. A. Faris, R. Xu, Z. Smith, P. Schnicker, N. J. Weber, M. M. 2024-12-01 doi:10.1101/2024.12.01.621710 Cold Spring Harbor Laboratory Press 2024-12-01 <![CDATA[ Decoding task representations that support generalization in hierarchical task ]]> https://biorxiv.org/content/10.1101/2024.12.02.626403v1?rss=1 Lee, W. Hazeltine, E. Jiang, J. 2024-12-02 doi:10.1101/2024.12.02.626403 Cold Spring Harbor Laboratory Press 2024-12-02 <![CDATA[ Matrix porosity is associated with Staphylococcus aureus biofilm survival during prosthetic joint infection ]]> https://biorxiv.org/content/10.1101/2024.12.06.627279v1?rss=1 Bhattacharya, M. Scherr, T. D. Lister, J. Kielian, T. Horswill, A. R. 2024-12-07 doi:10.1101/2024.12.06.627279 Cold Spring Harbor Laboratory Press 2024-12-07 <![CDATA[ The human RAD52 complex undergoes phase separation and facilitates bundling and end-to-end tethering of RAD51 presynaptic filaments ]]> https://biorxiv.org/content/10.1101/2024.12.09.627445v1?rss=1 Alshareedah, I. Pangeni, S. Dewan, P. A. Honda, M. Liao, T.-W. Spies, M. Ha, T. 2024-12-12 doi:10.1101/2024.12.09.627445 Cold Spring Harbor Laboratory Press 2024-12-12 <![CDATA[ Lipid Flipping, O-antigen Shielding, and Water Dynamics Revealed by 100-200 μs Coarse-Grained Simulations of E. coli Outer Membrane Proteins ]]> https://biorxiv.org/content/10.1101/2024.12.09.627556v1?rss=1 Kalenkiewicz, A. Elcock, A. H. 2024-12-12 doi:10.1101/2024.12.09.627556 Cold Spring Harbor Laboratory Press 2024-12-12 <![CDATA[ FABP5 in Skin Macrophages Mediates Saturated Fat-Induced IL-1β Signaling in Obesity-Associated Psoriasis Development ]]> https://biorxiv.org/content/10.1101/2024.12.16.628705v1?rss=1 View larger version (65K): org.highwire.dtl.DTLVardef@93fedaorg.highwire.dtl.DTLVardef@409fa2org.highwire.dtl.DTLVardef@b08362org.highwire.dtl.DTLVardef@81abcc_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Yu, J. Hao, J. Yorek, M. S. Jiang, X. Avellino, A. Liu, S. Han, X. Shilyansky, J. Wang, Z. Jabbari, A. Li, B. 2024-12-20 doi:10.1101/2024.12.16.628705 Cold Spring Harbor Laboratory Press 2024-12-20 <![CDATA[ Image Processing in the Acute to Chronic Pain Signatures (A2CPS) Project ]]> https://biorxiv.org/content/10.1101/2024.12.19.627509v1?rss=1 Sadil, P. Arfanakis, K. Bhuiyan, E. H. Caffo, B. Calhoun, V. D. Clauw, D. J. DeLano, M. C. Ford, J. C. Gattu, R. Guo, X. Harris, R. E. Ichesco, E. Johnson, M. A. Jung, H. Kahn, A. B. Kaplan, C. M. Leloudas, N. Lindquist, M. A. Luo, Q. Mulderink, T. A. Peltier, S. J. Prasad, P. V. Sica, C. Urrutia, J. Vance, C. G. Wager, T. D. Xuan, Y. Zhou, X. J. Zhou, Y. Shu, D. C. The Acute to Chronic Pain Signatures Consortium, 2024-12-20 doi:10.1101/2024.12.19.627509 Cold Spring Harbor Laboratory Press 2024-12-20 <![CDATA[ A single main-chain hydrogen bond required to keep GABAA receptors closed ]]> https://biorxiv.org/content/10.1101/2024.12.22.629966v1?rss=1 Borghese, C. M. Galpin, J. D. Lidbrink, S. E. Zhuang, Y. Desai, N. G. Howard, R. J. Lindahl, E. Ahern, C. A. Goldschen-Ohm, M. P. 2024-12-22 doi:10.1101/2024.12.22.629966 Cold Spring Harbor Laboratory Press 2024-12-22 <![CDATA[ A critical role of FAK signaling in Rac1-driven melanoma cell resistance to MAPK pathway inhibition ]]> https://biorxiv.org/content/10.1101/2024.12.22.629990v1?rss=1 Riordan, J. D. Nathanson, T. A. Varzavand, A. Hawkins, A. A. Peplinski, R. M. Hannan, E. C. Bibeau, F. A. Freesmeier, N. J. Jilek, M. C. Coma, S. Pachter, J. A. Dupuy, A. Stipp, C. S. 2024-12-23 doi:10.1101/2024.12.22.629990 Cold Spring Harbor Laboratory Press 2024-12-23 <![CDATA[ RiboTag-based RNA-Seq uncovers oligodendroglial lineage-specific inflammation in autoimmune encephalomyelitis ]]> https://biorxiv.org/content/10.1101/2024.12.24.630168v1?rss=1 Wang, Y. Ghimire, S. Mangalam, A. K. Kang, Z. 2024-12-24 doi:10.1101/2024.12.24.630168 Cold Spring Harbor Laboratory Press 2024-12-24 <![CDATA[ Dorsolateral prefrontal cortex TMS evokes responses in the subgenual anterior cingulate cortex: Evidence from human intracranial EEG ]]> https://biorxiv.org/content/10.1101/2024.12.20.629857v1?rss=1 Trapp, N. T. Liu, X. Li, Z. Bruss, J. Keller, C. J. Boes, A. D. Jiang, J. 2024-12-26 doi:10.1101/2024.12.20.629857 Cold Spring Harbor Laboratory Press 2024-12-26 <![CDATA[ Sex-specific survival but not tissue wasting in the KPP mouse model of pancreatic cancer-induced cachexia ]]> https://biorxiv.org/content/10.1101/2024.12.30.630679v1?rss=1 Weinzierl, N. Putri, J. Spitler, K. M. Talbert, E. E. 2024-12-31 doi:10.1101/2024.12.30.630679 Cold Spring Harbor Laboratory Press 2024-12-31 <![CDATA[ Mitochondrial Complex I and ROS control synapse function through opposing pre- and postsynaptic mechanisms ]]> https://biorxiv.org/content/10.1101/2024.12.30.630694v1?rss=1 Mallik, B. Frank, C. A. 2024-12-31 doi:10.1101/2024.12.30.630694 Cold Spring Harbor Laboratory Press 2024-12-31 <![CDATA[ Nerve Growth Factor Signaling Tunes Axon Maintenance Protein Abundance and Kinetics of Wallerian Degeneration ]]> https://biorxiv.org/content/10.1101/2024.12.31.630780v1?rss=1 Danos, J. A. Addemir, M. McGettigan, L. Summers, D. 2025-01-01 doi:10.1101/2024.12.31.630780 Cold Spring Harbor Laboratory Press 2025-01-01 <![CDATA[ Single-base m6A epitranscriptomics reveals novel HIV-1 host interaction targets in primary CD4+ T cells ]]> https://biorxiv.org/content/10.1101/2024.12.31.630958v1?rss=1 Huang, S. Zhao, Y. Phillips, S. Wilms, B. He, C. Wu, L. 2025-01-02 doi:10.1101/2024.12.31.630958 Cold Spring Harbor Laboratory Press 2025-01-02 <![CDATA[ Single-molecule analysis of PARP1-G-quadruplex interaction ]]> https://biorxiv.org/content/10.1101/2025.01.06.631587v1?rss=1 Gaur, P. Bain, F. E. Meah, R. Spies, M. 2025-01-08 doi:10.1101/2025.01.06.631587 Cold Spring Harbor Laboratory Press 2025-01-08 <![CDATA[ SAMHD1 enhances HIV-1-induced apoptosis in monocytic cells via the mitochondrial pathway ]]> https://biorxiv.org/content/10.1101/2025.01.08.632057v1?rss=1 Yang, H. Cheung, P.-H. H. Wu, L. 2025-01-10 doi:10.1101/2025.01.08.632057 Cold Spring Harbor Laboratory Press 2025-01-10 <![CDATA[ Long-Term Effects of Radiation Therapy on Cerebral Microvessel Proteome: A Six-Month Post-Exposure Analysis ]]> https://biorxiv.org/content/10.1101/2025.01.13.632491v1?rss=1 Subramanian, V. Juhr, D. Giansanti, P. Grumbach, I. M. 2025-01-17 doi:10.1101/2025.01.13.632491 Cold Spring Harbor Laboratory Press 2025-01-17 <![CDATA[ Integrated analysis of protein sequence and structureredefines viral diversity and the taxonomy of the Flaviviridae ]]> https://biorxiv.org/content/10.1101/2025.01.17.632993v1?rss=1 Simmonds, P. Butkovic, A. Grove, J. Mayne, R. Mifsud, J. C. Beer, M. Bukh, J. Drexler, J. F. Kapoor, A. Lohmann, V. Smith, D. B. Stapleton, J. T. Vasilakis, N. Kuhn, J. H. 2025-01-18 doi:10.1101/2025.01.17.632993 Cold Spring Harbor Laboratory Press 2025-01-18 <![CDATA[ Altered Relaxation and Mitochondria-Endoplasmic Reticulum Contact Sites Precede Major (Mal)adaptations in Aging Skeletal Muscle and are Prevented by Exercise ]]> https://biorxiv.org/content/10.1101/2025.01.14.633043v1?rss=1 Allen, R. J. Kronemberger, A. Shi, Q. Pope, M. Cuadra-Munoz, E. Son, W. Song, L.-S. Anderson, E. J. Pereira, R. O. Lira, V. A. 2025-01-19 doi:10.1101/2025.01.14.633043 Cold Spring Harbor Laboratory Press 2025-01-19 <![CDATA[ PI3K regulates TAZ/YAP and mTORC1 axes that can be synergistically targeted ]]> https://biorxiv.org/content/10.1101/2025.01.21.634138v1?rss=1 Garcia, K. C. Khan, A. A. Ghosh, K. Sinha, S. Scalora, N. DeWane, G. Fullenkamp, C. Merritt, N. Drebot, Y. Yu, S. Leidinger, M. Henry, M. D. Breheny, P. Chimenti, M. S. Tanas, M. R. 2025-01-22 doi:10.1101/2025.01.21.634138 Cold Spring Harbor Laboratory Press 2025-01-22 <![CDATA[ Characterization of nuclear genome size and variation in a freshwater snail model system featuring a recent whole-genome duplication ]]> https://biorxiv.org/content/10.1101/2025.01.23.634510v1?rss=1 Neiman, M. Pilcher, M. Haase, M. Lamatsch, D. 2025-01-25 doi:10.1101/2025.01.23.634510 Cold Spring Harbor Laboratory Press 2025-01-25 <![CDATA[ Carbonic anhydrase 4 disruption and pharmacological inhibition reduce synaptic and behavioral adaptations following oxycodone withdrawal ]]> https://biorxiv.org/content/10.1101/2025.01.23.634619v1?rss=1 Gupta, S. C. Taugher-Hebl, R. J. Ghobbeh, A. Jahnke, M. T. Fan, R. Lalumiere, R. T. Wemmie, J. A. 2025-01-25 doi:10.1101/2025.01.23.634619 Cold Spring Harbor Laboratory Press 2025-01-25 <![CDATA[ Threshold effects of prenatal stress on striatal microglia and relevant behaviors ]]> https://biorxiv.org/content/10.1101/2025.01.30.635666v1?rss=1 Maurer, S. V. Evans, M. M. Dukle, M. Kundu, S. Dennis, J. L. Ellerbroek, R. M. Anema, S. L. Roshko, V. C. Stevens, H. E. 2025-01-30 doi:10.1101/2025.01.30.635666 Cold Spring Harbor Laboratory Press 2025-01-30 <![CDATA[ Overexpression of GITRL by B cell IgD low (BDL) B cells is a therapeutic strategy to increase endogenous CD4+Foxp3+ T regulatory cells for the treatment of autoimmunity ]]> https://biorxiv.org/content/10.1101/2025.02.04.636512v1?rss=1 Khalil, M. I. Gurski, C. J. Burns, R. Zander, R. Sommers, K. C. Beltrame, A. K. Dittel, B. N. 2025-02-08 doi:10.1101/2025.02.04.636512 Cold Spring Harbor Laboratory Press 2025-02-08 <![CDATA[ Brain bases for navigating acoustic features ]]> https://biorxiv.org/content/10.1101/2025.02.10.636597v1?rss=1 Billig, A. J. Sedley, W. Gander, P. E. Kumar, S. Lad, M. J. Chait, M. Mohammadi, Y. Berger, J. I. Griffiths, T. 2025-02-10 doi:10.1101/2025.02.10.636597 Cold Spring Harbor Laboratory Press 2025-02-10 <![CDATA[ Defects in nephrogenesis result in an expansion of the Foxd1+ stromal progenitor population ]]> https://biorxiv.org/content/10.1101/2025.02.10.637031v1?rss=1 Michalopulos, M. G. Liu, Y. Raju, D. R. Lafin, J. T. Ma, Y. Gaur, D. Khadka, S. Xing, C. McMahon, A. P. Carroll, T. J. Drake, K. A. 2025-02-11 doi:10.1101/2025.02.10.637031 Cold Spring Harbor Laboratory Press 2025-02-11 <![CDATA[ Alternative approaches to single-cell trajectory inference using a commute time matrix ]]> https://biorxiv.org/content/10.1101/2025.02.12.635984v1?rss=1 Houston, D. W. 2025-02-14 doi:10.1101/2025.02.12.635984 Cold Spring Harbor Laboratory Press 2025-02-14 <![CDATA[ Polo-like kinase 1 maintains transcription and chromosomal accessibility during mitosis ]]> https://biorxiv.org/content/10.1101/2025.02.12.637959v1?rss=1 Shen, Z. Adams, K. M. Moreno, R. Lera, R. Kaufman, E. Bukard, M. E. 2025-02-16 doi:10.1101/2025.02.12.637959 Cold Spring Harbor Laboratory Press 2025-02-16 <![CDATA[ IFIT3 RNA-binding activity promotes influenza A virus infection and translation efficiency ]]> https://biorxiv.org/content/10.1101/2025.02.17.638785v1?rss=1 Sullivan, O. M. Nesbitt, D. J. Schaack, G. A. Feltman, E. Nipper, T. Kongsomros, S. Reed, S. G. Nelson, S. L. King, C. R. Shishkova, E. Coon, J. J. Mehle, A. 2025-02-19 doi:10.1101/2025.02.17.638785 Cold Spring Harbor Laboratory Press 2025-02-19 <![CDATA[ Influence of contextual exposure on memory strength and precision for inhibitory avoidance in male and female rats ]]> https://biorxiv.org/content/10.1101/2025.02.27.640186v1?rss=1 Holm, A. R. Radley, J. J. LaLumiere, R. T. 2025-03-01 doi:10.1101/2025.02.27.640186 Cold Spring Harbor Laboratory Press 2025-03-01 <![CDATA[ Production of clinical grade patient iPSC-derived 3D retinal organoids containing transplantable photoreceptor cells ]]> https://biorxiv.org/content/10.1101/2025.03.04.640656v1?rss=1 Bohrer, L. R. Wiley, L. A. Wright, A. T. Hittle, B. Affatigato, L. M. Lang, M. J. Powell, K. A. Haefeli, L. M. Han, I. C. Mullins, R. F. Stone, E. M. Tucker, B. A. 2025-03-10 doi:10.1101/2025.03.04.640656 Cold Spring Harbor Laboratory Press 2025-03-10 <![CDATA[ Rapidly evolved genomic regions shape individual language abilities in present-day humans ]]> https://biorxiv.org/content/10.1101/2025.03.07.641231v1?rss=1 Casten, L. G. Koomar, T. Thomas, T. R. Koh, J.-Y. Hofammann, D. Thenuwara, S. Momany, A. O'Brien, M. Murray, J. C. Tomblin, J. B. Michaelson, J. J. 2025-03-11 doi:10.1101/2025.03.07.641231 Cold Spring Harbor Laboratory Press 2025-03-11 <![CDATA[ The ectodermal loss of ARHGAP29 alters epithelial morphology and organization and disrupts murine palatal development ]]> https://biorxiv.org/content/10.1101/2025.03.11.642653v1?rss=1 Adelizzi, E. Rhea, L. Mitvalsky, C. Pek, S. Doolittle, B. Dunnwald, M. 2025-03-13 doi:10.1101/2025.03.11.642653 Cold Spring Harbor Laboratory Press 2025-03-13 <![CDATA[ Human insula neurons respond to simple sounds during passive listening ]]> https://biorxiv.org/content/10.1101/2025.03.12.642819v1?rss=1 Berger, J. I. Kawasaki, H. Banks, M. I. Kumar, S. Howard, M. A. Nourski, K. V. 2025-03-13 doi:10.1101/2025.03.12.642819 Cold Spring Harbor Laboratory Press 2025-03-13 <![CDATA[ Single-cell resolution spatial transcriptomic signature of the retrosplenial cortex during memory consolidation ]]> https://biorxiv.org/content/10.1101/2025.03.12.642891v1?rss=1 Bliese, S. R. Basu, B. Beyer, S. E. Chatterjee, S. 2025-03-13 doi:10.1101/2025.03.12.642891 Cold Spring Harbor Laboratory Press 2025-03-13 <![CDATA[ Glial Contribution to the Pathogenesis of Post-Operative Delirium Revealed by Multi-omic Analysis of Brain Tissue from Neurosurgery Patients ]]> https://biorxiv.org/content/10.1101/2025.03.13.643155v1?rss=1 Ishii, T. Wang, T. Shibata, K. Nishitani, S. Yamanashi, T. Wahba, N. E. Seki, T. Thompson, K. J. Yamanishi, K. Nishiguchi, T. Shimura, A. Aoyama, B. Gorantla, N. Phuong, N. J. Nguyen, H. D. Santiago, T. A. Nishizawa, Y. Nagao, T. Howard, M. A. Kawasaki, H. Hino, K. Ikeda, A. Snyder, M. P. Shinozaki, G. 2025-03-14 doi:10.1101/2025.03.13.643155 Cold Spring Harbor Laboratory Press 2025-03-14 <![CDATA[ The Chlamydia trachomatis secreted effector protein CT181 binds to Mcl-1 to prolong neutrophil survival ]]> https://biorxiv.org/content/10.1101/2025.03.16.643443v1?rss=1 Faris, R. Koch, R. McCaslin, P. Challagundla, N. Steiert, B. Andersen, S. Smith, P. Jabeena, C. A. Yau, P. Rudel, T. Weber, M. M. 2025-03-16 doi:10.1101/2025.03.16.643443 Cold Spring Harbor Laboratory Press 2025-03-16 <![CDATA[ Maternal α-cypermethrin and permethrin exert differential effects on fetal growth, placental morphology, and fetal neurodevelopment in mice ]]> https://biorxiv.org/content/10.1101/2025.03.16.643434v1?rss=1 Elser, B. A. Hing, B. Eliasen, S. Afrifa, M. A. Meurice, N. Rimi, F. Chimenti, M. Schulz, L. C. Dailey, M. E. Gibson-Corley, K. N. Stevens, H. E. 2025-03-17 doi:10.1101/2025.03.16.643434 Cold Spring Harbor Laboratory Press 2025-03-17 <![CDATA[ Whole-genome sequence of Potamopyrgus antipodarum: a model system for the maintenance of sexual reproduction reveals a recent whole-genome duplication ]]> https://biorxiv.org/content/10.1101/2025.03.16.643514v1?rss=1 Jalinsky, J. R. McElroy, K. E. Sharbrough, J. Bankers, L. Fields, P. Higgins, C. Toll, C. Boore, J. Logsdon, J. M. Neiman, M. 2025-03-17 doi:10.1101/2025.03.16.643514 Cold Spring Harbor Laboratory Press 2025-03-17 <![CDATA[ Efficient gastrointestinal colonization by Campylobacter jejuni requires components of the ChuABCD heme transport system ]]> https://biorxiv.org/content/10.1101/2025.03.18.643992v1?rss=1 Randaisi, V. R. Bunch, M. L. Beavers, W. N. Rogers, T. Ashurst, T. D. Donohoe, D. Monteith, A. J. Johnson, J. 2025-03-19 doi:10.1101/2025.03.18.643992 Cold Spring Harbor Laboratory Press 2025-03-19 <![CDATA[ Immortalization and Characterization of Schwann Cell Lines Derived from NF1 Associated Cutaneous Neurofibromas ]]> https://biorxiv.org/content/10.1101/2025.03.19.643702v1?rss=1 Li, H. Pemov, A. Allaway, R. J. Muir, D. F. Chang, L.-J. Banerjee, J. Scott, A. J. Nagy, J. M. Liu, J. Carrio, M. Mazuelas, H. Yachnis, A. Lee, S. Y. Zhang, X. Lyu, Y. Stewart, D. R. Hirbe, A. Blakeley, J. O. Serra, E. Wallis, D. Wallace, M. R. 2025-03-20 doi:10.1101/2025.03.19.643702 Cold Spring Harbor Laboratory Press 2025-03-20 <![CDATA[ How Task Representations Integrate Information from Multiple Sources ]]> https://biorxiv.org/content/10.1101/2025.03.21.644222v1?rss=1 Leach, S. C. Morrow, H. Jiang, J. Hwang, K. 2025-03-21 doi:10.1101/2025.03.21.644222 Cold Spring Harbor Laboratory Press 2025-03-21 <![CDATA[ cAMP-related second messenger pathways modulate hearing function in Aedes aegypti mosquitoes ]]> https://biorxiv.org/content/10.1101/2025.03.23.644695v1?rss=1 Xu, Y. Y. J. Loh, Y. M. Lee, T.-T. Chen, W.-T. Loh, W. Ohashi, T. S. Eberl, D. F. Andres, M. Su, M. P. Kamikouchi, A. 2025-03-24 doi:10.1101/2025.03.23.644695 Cold Spring Harbor Laboratory Press 2025-03-24 <![CDATA[ Cargo adaptors use a handhold mechanism to engage with myosin V for organelle transport ]]> https://biorxiv.org/content/10.1101/2025.03.24.645041v1?rss=1 Hahn, H. J. Pashkova, N. Cianfrocco, M. A. Weisman, L. S. 2025-03-25 doi:10.1101/2025.03.24.645041 Cold Spring Harbor Laboratory Press 2025-03-25 <![CDATA[ Long-term editing of brain circuits in mice using an engineered electrical synapse ]]> https://biorxiv.org/content/10.1101/2025.03.25.645291v1?rss=1 Ransey, E. Thomas, G. Wisdom, E. Almoril-Porras, A. Bowman, R. Adamson, E. Walder-Christensen, K. K. White, J. A. Hughes, D. N. Schwennesen, H. Ferguson, C. Tye, K. Mague, S. D. Niu, L.-G. Wang, Z.-W. Colon-Ramos, D. Hultman, R. Bursac, N. Dzirasa, K. 2025-03-26 doi:10.1101/2025.03.25.645291 Cold Spring Harbor Laboratory Press 2025-03-26 <![CDATA[ EHE cell cultures: a platform for mechanistic and therapeutic investigation ]]> https://biorxiv.org/content/10.1101/2025.03.24.644191v1?rss=1 Scalora, N. DeWane, G. Drebot, Y. Khan, A. A. Sinha, S. Ghosh, K. Robinson, D. Cogswell, P. Bellizzi, A. M. Snow, A. N. Breheny, P. Chimenti, M. S. Tanas, M. R. 2025-03-27 doi:10.1101/2025.03.24.644191 Cold Spring Harbor Laboratory Press 2025-03-27 <![CDATA[ Placental Igf1 Overexpression Sex-Specifically Impacts Mouse Placenta Structure, Altering Offspring Striatal Development and Behavior ]]> https://biorxiv.org/content/10.1101/2025.03.27.644829v1?rss=1 View larger version (72K): org.highwire.dtl.DTLVardef@22f53borg.highwire.dtl.DTLVardef@1120913org.highwire.dtl.DTLVardef@111c61forg.highwire.dtl.DTLVardef@1e6531d_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Carver, A. J. Fairbairn, F. M. Taylor, R. J. Boggarapu, S. Kamau, N. R. Gajmer, A. Stevens, H. E. 2025-03-29 doi:10.1101/2025.03.27.644829 Cold Spring Harbor Laboratory Press 2025-03-29 <![CDATA[ Deletion of the voltage-gated calcium channel gene, CaV1.3, reduces Purkinje cell dendritic complexity without altering cerebellar-mediated eyeblink conditioning ]]> https://biorxiv.org/content/10.1101/2025.03.27.645586v1?rss=1 Klomp, A. Pace, M. Mehr, J. Arrieta, M. F. H. Hayes, C. Fleck, A. Heiney, S. Williams, A. J. 2025-03-29 doi:10.1101/2025.03.27.645586 Cold Spring Harbor Laboratory Press 2025-03-29 <![CDATA[ DLPFC Stimulation Suppresses High-Frequency Neural Activity in the Human sgACC ]]> https://biorxiv.org/content/10.1101/2025.03.26.645556v1?rss=1 Solomon, E. A. Hassan, U. Trapp, N. T. Boes, A. D. Keller, C. J. 2025-04-01 doi:10.1101/2025.03.26.645556 Cold Spring Harbor Laboratory Press 2025-04-01 <![CDATA[ Epigenetic Modulation, Intra-tumoral Microbiome and Immunity in Early Onset Colorectal Cancer ]]> https://biorxiv.org/content/10.1101/2025.03.28.645992v1?rss=1 Jin, N. Hoyd, R. Yilmaz, A. S. Zhu, J. Liu, Y. Singh, M. J. Grencewicz, D. Mo, X. Kalady, M. Rosenberg, D. Dravillas, C. E. Singer, E. A. Carpten, J. D. Chan, C. H. Churchman, M. L. Denko, N. C. Di Clemente, F. Dodd, R. D. Eljilany, I. Fei, N. Hardikar, S. Ikeguchi, A. P. Ma, A. Ma, Q. McCarter, M. D. Osman, A. E. Riedlinger, G. Robinson, L. A. Schneider, B. P. Tarhini, A. A. Tinoco, G. Figueiredo, J. Zakharia, Y. Ulrich, C. M. Tan, A. C. Spakowicz, D. 2025-04-02 doi:10.1101/2025.03.28.645992 Cold Spring Harbor Laboratory Press 2025-04-02 <![CDATA[ Glycolysis-enhancing alpha 1-adrenergic antagonists are neuroprotective in Alzheimers disease ]]> https://biorxiv.org/content/10.1101/2025.04.03.647018v1?rss=1 Zhang, Q. Schultz, J. Simmering, J. Kirkpatrick, B. Q. Weber, M. A. Skuodas, S. Hicks, T. Pierce, G. Laughlin, M. Bertolli, A. X. Larson, T. Thangavel, R. Oya, M. Meyerholz, D. Aldridge, G. Fassler, J. Narayanan, N. S. 2025-04-03 doi:10.1101/2025.04.03.647018 Cold Spring Harbor Laboratory Press 2025-04-03 <![CDATA[ Ebola's Hidden Target: Virus Transmission to and Accumulation within Skin ]]> https://biorxiv.org/content/10.1101/2025.04.04.647113v1?rss=1 Richards, P. T. Fleck, A. Patel, R. Fakhimi, M. Bohan, D. Geohegan-Barek, K. Stolte, A. E. Messingham, C. O. Connell, S. Crowe, T. Gourronc, F. A. Carrion, R. Griffiths, A. Meyerholz, D. K. Klingelhutz, A. J. Davey, R. A. Messingham, K. N. Maury, W. 2025-04-04 doi:10.1101/2025.04.04.647113 Cold Spring Harbor Laboratory Press 2025-04-04 <![CDATA[ Listening to the room: disrupting activity of dorsolateral prefrontal cortex impairs learning of room acoustics in human listeners ]]> https://biorxiv.org/content/10.1101/2025.04.04.644835v1?rss=1 Hernandez-Perez, H. Mikiel-Hunter, J. Traer, J. Monaghan, J. Sowman, P. McAlpine, D. 2025-04-05 doi:10.1101/2025.04.04.644835 Cold Spring Harbor Laboratory Press 2025-04-05 <![CDATA[ Tick-borne coinfections modulate CD8+ T cell response and progressive leishmaniosis ]]> https://biorxiv.org/content/10.1101/2025.04.03.647089v1?rss=1 Scorza, B. M. Pessoa-Pereira, D. Pabon-Rodriguez, F. Beasley, E. A. Mahachi, K. Cox, A. D. Kontowicz, E. Baccam, T. Wilson, G. Waugh, M. C. Vollmer, S. Toepp, A. Raju, K. Chigbo, O. Elliff, J. Becker, G. Cyndari, K. I. Tang, S. Brown, G. Petersen, C. A. 2025-04-07 doi:10.1101/2025.04.03.647089 Cold Spring Harbor Laboratory Press 2025-04-07 <![CDATA[ K48-ubiquitin-activated proteases cut-up post-ER proteins ]]> https://biorxiv.org/content/10.1101/2025.04.13.648637v1?rss=1 Minard, A. Y. Winistorfer, S. Yu, L. Piper, R. C. 2025-04-14 doi:10.1101/2025.04.13.648637 Cold Spring Harbor Laboratory Press 2025-04-14 <![CDATA[ Brief Pulses of High-Level Fluid Shear Stress Enhance Metastatic Potential and Rapidly Alter the Metabolism of Cancer Cells. ]]> https://biorxiv.org/content/10.1101/2025.04.09.647247v1?rss=1 Pope, A. N. Moose, D. L. Hudson, G. O. Weresh, H. R. Taylor, E. B. Henry, M. D. 2025-04-15 doi:10.1101/2025.04.09.647247 Cold Spring Harbor Laboratory Press 2025-04-15 <![CDATA[ The superficial tufted and mitral cell output neurons of the mouse olfactory bulb have a dual role in insulin sensing ]]> https://biorxiv.org/content/10.1101/2025.04.15.648999v1?rss=1 Kolling, L. J. Marcinkiewcz, C. Fadool, D. A. 2025-04-20 doi:10.1101/2025.04.15.648999 Cold Spring Harbor Laboratory Press 2025-04-20 <![CDATA[ Controlled Release of Bone Morphogenetic Protein-2 Improves Motor Function After Traumatic Brain Injury in a Rat Model ]]> https://biorxiv.org/content/10.1101/2025.04.16.649206v1?rss=1 View larger version (25K): org.highwire.dtl.DTLVardef@136d4d4org.highwire.dtl.DTLVardef@cee564org.highwire.dtl.DTLVardef@13612e8org.highwire.dtl.DTLVardef@1134b4c_HPS_FORMAT_FIGEXP M_FIG C_FIG Statement of SignificanceSevere traumatic brain injury (TBI) is a life-threatening condition characterized by internal brain swelling and is commonly treated using a two-stage surgical approach. Complications associated with the two-stage treatment paradigm include secondary neurologic impairment, termed syndrome of the trephined (SOT). SOT is often reversible once the second surgery is performed, whereas a single-stage TBI treatment paradigm may avoid the occurrence of SOT altogether. Utilizing hydrogels comprised of pentenoate-modified hyaluronic acid and thiolated devitalized tendon encapsulating microspheres containing bone morphogenetic protein-2 (BMP-2), the current study demonstrated improvements in motor skill function and reductions in brain atrophy in a rat TBI model. The introduction of hydrogels with controlled release of BMP-2 as a neuroprotective strategy for TBI application offers a promising approach for single-stage TBI treatment. ]]> Townsend, J. M. Deng, J. Z. Barbay, S. Andrews, B. T. Nudo, R. J. Detamore, M. S. 2025-04-22 doi:10.1101/2025.04.16.649206 Cold Spring Harbor Laboratory Press 2025-04-22 <![CDATA[ Interactions between the medial prefrontal cortex, dorsomedial striatum, and dorsal hippocampus that support rat category learning ]]> https://biorxiv.org/content/10.1101/2025.04.21.649785v1?rss=1 View larger version (57K): org.highwire.dtl.DTLVardef@ba3342org.highwire.dtl.DTLVardef@7b62a4org.highwire.dtl.DTLVardef@890676org.highwire.dtl.DTLVardef@75f84_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Broschard, M. B. Kim, J. Halverson, H. E. Farley, S. J. Freeman, J. H. 2025-04-22 doi:10.1101/2025.04.21.649785 Cold Spring Harbor Laboratory Press 2025-04-22 <![CDATA[ Oncogene SETDB1s Dual Role in Endometrial Cancer: Driving Tumor Progression and Immune Escape ]]> https://biorxiv.org/content/10.1101/2025.04.23.650291v1?rss=1 Salari, K. Hao, J. Jilek, R. Wells, M. Li, T. Johnson, E. Meng, W. Zibble, E. Allen, A. Gilbert, J. McLerran, R. Schuett, E. Oliva, C. Griguer, C. E. Meyerholz, D. K. Yates, M. Keen, H. L. Meng, X. Xiong, Y. Li, B. Yang, S. 2025-04-29 doi:10.1101/2025.04.23.650291 Cold Spring Harbor Laboratory Press 2025-04-29 <![CDATA[ Tbr2-Dependent Parallel Pathways Regulate the Development of Distinct ipRGC Subtypes ]]> https://biorxiv.org/content/10.1101/2025.04.29.651262v1?rss=1 Kiyama, T. Chen, C.-K. Altay, H. Y. Chen, Y.-J. Sigala, L. Su, D. Eliason, S. L. Amendt, B. Mao, C.-A. 2025-05-01 doi:10.1101/2025.04.29.651262 Cold Spring Harbor Laboratory Press 2025-05-01 <![CDATA[ Th1 effector CD4 T cells rely on IFN-γ production to induce alopecia areata ]]> https://biorxiv.org/content/10.1101/2025.05.07.650678v1?rss=1 Connell, S. J. Crotts, S. Reis, R. Lensing, M. Kahl, P. Henderson, N. Ayush, O. Zhu, Z. Ortolan, L. S. Harty, J. Goverman, J. Jabbari, A. 2025-05-07 doi:10.1101/2025.05.07.650678 Cold Spring Harbor Laboratory Press 2025-05-07 <![CDATA[ The lipid droplet protein Jabba promotes actin remodeling downstream of prostaglandin signaling during Drosophila oogenesis ]]> https://biorxiv.org/content/10.1101/2025.05.09.653087v1?rss=1 Thomalla, J. M. Giedt, M. S. White, R. P. Wipf, I. J. Shipley, A. Welte, M. A. Tootle, T. L. 2025-05-13 doi:10.1101/2025.05.09.653087 Cold Spring Harbor Laboratory Press 2025-05-13 <![CDATA[ Ferret model of bleomycin-induced lung injury shares features of human idiopathic pulmonary fibrosis ]]> https://biorxiv.org/content/10.1101/2025.05.08.652970v1?rss=1 Wu, S. Driver, I. Luo, M. Miyazaki, H. Shambhu, S. Popov, D. Yang, L. Wang, J. Ma, J. Guo, J. Atha, J. Tata, A. Hoffman, E. Wang, Y. Tata, P. Jensen, M. B. Engelhardt, J. F. Sontake, V. Liu, X. 2025-05-14 doi:10.1101/2025.05.08.652970 Cold Spring Harbor Laboratory Press 2025-05-14 <![CDATA[ Seizure Circuit Activity in the Theilers Murine Encephalomyelitis Virus Model of Infection-induced Epilepsy Using Transient Recombination in Active Populations. ]]> https://biorxiv.org/content/10.1101/2025.05.20.655185v1?rss=1 View larger version (20K): org.highwire.dtl.DTLVardef@bbcd75org.highwire.dtl.DTLVardef@1add030org.highwire.dtl.DTLVardef@3f3aa5org.highwire.dtl.DTLVardef@1233312_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Petrucci, A. N. Abel, T. N. Wilcox, K. S. 2025-05-21 doi:10.1101/2025.05.20.655185 Cold Spring Harbor Laboratory Press 2025-05-21 <![CDATA[ Alcohol Disrupts Neural Differentiation Through Endoplasmic Reticulum Stress and PERK Pathway Activation ]]> https://biorxiv.org/content/10.1101/2025.05.16.654531v1?rss=1 Zhang, Z. Wen, W. Lin, H. Hu, D. Li, H. Luo, J. 2025-05-22 doi:10.1101/2025.05.16.654531 Cold Spring Harbor Laboratory Press 2025-05-22 <![CDATA[ Molecular Basis of Sodium Channel Inactivation ]]> https://biorxiv.org/content/10.1101/2025.05.22.655422v1?rss=1 Liu, Y. Galpin, J. Ahern, C. A. Bezanilla, F. 2025-05-23 doi:10.1101/2025.05.22.655422 Cold Spring Harbor Laboratory Press 2025-05-23 <![CDATA[ ALPHA/BETA HYDROLASE DOMAIN CONTAINING 5 SUPPORTS GLUCOSE-STIMULATED-LIPOLYSIS AND INSULIN SECRETION IN PANCREATIC BETA CELLS ]]> https://biorxiv.org/content/10.1101/2025.05.21.655350v1?rss=1 Kim, L. Liu, S. Peachee, S. Richtsmeier, S. Jun, C. Gianna, S. Vikram, A. Freshly, A. Imai, Y. 2025-05-24 doi:10.1101/2025.05.21.655350 Cold Spring Harbor Laboratory Press 2025-05-24 <![CDATA[ A dataset of adult heart and liver mass after placental Insulin-like growth factor 1 overexpression and partial knockout in mice ]]> https://biorxiv.org/content/10.1101/2025.05.23.655797v1?rss=1 Fairbairn, F. M. Carver, A. J. Taylor, R. J. Stevens, H. E. 2025-05-28 doi:10.1101/2025.05.23.655797 Cold Spring Harbor Laboratory Press 2025-05-28 <![CDATA[ A new mouse mutant with a discrete mutation in Pcdhgc5 reveals that the Protocadherin γC5 isoform is not essential for dendrite arborization in the cerebral cortex ]]> https://biorxiv.org/content/10.1101/2025.05.28.656572v1?rss=1 Hanes, C. M. Steffen, D. M. Murray, G. C. Burgess, R. W. Weiner, J. A. Garrett, A. M. 2025-05-28 doi:10.1101/2025.05.28.656572 Cold Spring Harbor Laboratory Press 2025-05-28 <![CDATA[ Therapeutic antisense oligonucleotide mitigates retinal dysfunction in a pig model of CLN3 Batten disease ]]> https://biorxiv.org/content/10.1101/2025.05.30.656864v1?rss=1 Stratton, M. P. Centa, J. L. Swier, V. J. Pfeifer, W. L. Booth, C. D. Albert, K. Hunyara, J. L. Rechtzigel, M. J. Duelli, F. J. Leppert, H. G. Rigo, F. Smit, T. Jafar-Nejad, P. Weimer, J. M. Drack, A. V. Hastings, M. L. 2025-05-31 doi:10.1101/2025.05.30.656864 Cold Spring Harbor Laboratory Press 2025-05-31 <![CDATA[ Dexmedetomidine produces more sleep-like brain activity compared to propofol ]]> https://biorxiv.org/content/10.1101/2025.05.27.656383v1?rss=1 Krause, B. M. Dappen, E. R. Mueller, R. N. Kawasaki, H. Sanders, R. D. Nourski, K. V. Banks, M. I. 2025-06-01 doi:10.1101/2025.05.27.656383 Cold Spring Harbor Laboratory Press 2025-06-01 <![CDATA[ A simple method for introducing a cutoff to hydrodynamic interactions in Brownian dynamics simulations ]]> https://biorxiv.org/content/10.1101/2025.05.31.657166v1?rss=1 Elcock, A. H. 2025-06-03 doi:10.1101/2025.05.31.657166 Cold Spring Harbor Laboratory Press 2025-06-03 <![CDATA[ BifurcatoR: A Framework for Revealing Clinically Actionable Signal in Variance Masquerading as Noise ]]> https://biorxiv.org/content/10.1101/2025.06.01.657083v1?rss=1 Madaj, Z. B. Ding, M. Khoo, C. K. Tokarski, E. Fagnocchi, L. PERMUTE, Li, Z. Riordan, J. Pospisilik, J. A. Nadeau, J. Lary, C. Triche, T. J. 2025-06-03 doi:10.1101/2025.06.01.657083 Cold Spring Harbor Laboratory Press 2025-06-03 <![CDATA[ Resting-state functional dynamics alterations relate to plasma amyloid markers and explain memory impairments in the TgF344-AD model of Alzheimer's disease ]]> https://biorxiv.org/content/10.1101/2025.06.01.657264v1?rss=1 Al Awlaqi, A. De Waegenaere, S. Berckmans, L. Vanherle, S. Griffis, J. Dewachter, I. Verhoye, M. Adhikari, M. H. 2025-06-03 doi:10.1101/2025.06.01.657264 Cold Spring Harbor Laboratory Press 2025-06-03 <![CDATA[ Primary tumor microbiomes predict distant metastasis of colorectal cancer ]]> https://biorxiv.org/content/10.1101/2025.06.02.654060v1?rss=1 Parajuli, B. Midya, V. Kiddle, R. De Jager, N. Eggers, S. Spakowicz, D. Hoyd, R. Salhia, B. Chan, C. H. Churchman, M. Rounbehler, R. J. Yao, S. Rutkowski, M. R. Tarhini, A. A. Mudaranthakam, D. P. Masood, A. Bocklage, T. J. Lentz, R. W. Hatoum, H. Ilozumba, M. N. Hardikar, S. Ulrich, C. M. Round, J. L. Riedlinger, G. Shriver, C. D. Bosch, D. E. 2025-06-05 doi:10.1101/2025.06.02.654060 Cold Spring Harbor Laboratory Press 2025-06-05 <![CDATA[ Analysis of Essential Genes in Clostridioides difficile by CRISPRi and Tn-seq ]]> https://biorxiv.org/content/10.1101/2025.06.04.657922v1?rss=1 90% of the targeted genes and observed morphological defects for >80% of them. Second, we conducted a new Tn-seq analysis, which identified 346 genes as essential, of which 283 are in common with the previous report and might be considered a provisional essential gene set that minimizes false positives. We compare the list of essential genes to those of other bacteria, especially Bacillus subtilis, highlighting some noteworthy differences. Finally, we used fusions to red fluorescent protein (RFP) to identify 18 putative new cell division proteins, three of which are conserved in Bacillota but of largely unknown function. Collectively, our findings provide new tools and insights that advance our understanding of C. difficile. IMPORTANCEClostridioides difficile is an opportunistic pathogen for which better antibiotics are sorely needed. Most antibiotics target pathways that are essential for viability. Here we use saturation transposon mutagenesis and gene silencing with CRISPR interference to identify and characterize genes required for growth on laboratory media. Comparison to the model organism B. subtilis reveals many similarities and a few striking differences that warrant further study and may include opportunities for developing antibiotics that kill C. difficile without decimating the healthy microbiota needed to keep C. difficile in check. ]]> Alberts, M. Kurtz, M. Müh, U. Bernardi, J. Bollinger, K. Duncan, L. Dobrila, H. A. Laster, H. Orea, A. Pannullo, A. Rivera-Rosado, J. Torres, F. Ellermeier, C. D. Weiss, D. S. 2025-06-07 doi:10.1101/2025.06.04.657922 Cold Spring Harbor Laboratory Press 2025-06-07 <![CDATA[ Developing inhibitors of the guanosine triphosphate hydrolysis accelerating activity of Regulator of G protein Signaling-14 ]]> https://biorxiv.org/content/10.1101/2025.06.11.659181v1?rss=1 Agogo-Mawuli, P. S. Sadiya, I. Bosch, D. E. Emmitte, K. A. Colon-Perez, L. Kosloff, M. Siderovski, D. P. 2025-06-17 doi:10.1101/2025.06.11.659181 Cold Spring Harbor Laboratory Press 2025-06-17 <![CDATA[ Brain Representations of Natural Sound Statistics ]]> https://biorxiv.org/content/10.1101/2025.06.17.660096v1?rss=1 Mohammadi, Y. Billig, A. J. Berger, J. I. Griffiths, T. 2025-06-17 doi:10.1101/2025.06.17.660096 Cold Spring Harbor Laboratory Press 2025-06-17 <![CDATA[ Neural activity flows through cortical subnetworks during speech production ]]> https://biorxiv.org/content/10.1101/2025.06.20.660783v1?rss=1 Castellucci, G. A. MacKay, M. Kovach, C. K. Tabasi, F. Greenlee, J. D. W. Long, M. A. 2025-06-21 doi:10.1101/2025.06.20.660783 Cold Spring Harbor Laboratory Press 2025-06-21 <![CDATA[ Remote sensing of endogenous pigmentation by inducible synthetic circuits in grasses ]]> https://biorxiv.org/content/10.1101/2025.06.20.660755v1?rss=1 Lee, D.-Y. Acosta-Gamboa, L. Saleh, L. Pathak, S. Swyers, N. Morgan, A. Meerdink, S. Kuzio, C. Calderon, S. Sheng, H. Kenney, S. Zare, A. Gehan, M. Nusinow, D. A. 2025-06-23 doi:10.1101/2025.06.20.660755 Cold Spring Harbor Laboratory Press 2025-06-23 <![CDATA[ A Dual-Compartment Scaffolding Role for RACK1 in Hepatic Glucagon Signaling and Gluconeogenesis ]]> https://biorxiv.org/content/10.1101/2025.06.18.660434v1?rss=1 Lyu, C. C. Yang, L. Chen, S. 2025-06-24 doi:10.1101/2025.06.18.660434 Cold Spring Harbor Laboratory Press 2025-06-24 <![CDATA[ Molecular prosthetics and CFTR modulators additively increase secretory HCO- flux in cystic fibrosis airway epithelia ]]> https://biorxiv.org/content/10.1101/2025.06.18.660463v1?rss=1 Celis, N. Miller, D. P. Tarara, T. E. Weers, J. G. Thornell, I. M. Welsh, M. J. Burke, M. D. 2025-06-24 doi:10.1101/2025.06.18.660463 Cold Spring Harbor Laboratory Press 2025-06-24 <![CDATA[ Functional genomics and tumor microenvironment analysis reveal prognostic biological subtypes in Mantle cell lymphoma ]]> https://biorxiv.org/content/10.1101/2025.06.25.661613v1?rss=1 Sharma, S. Ali, R. Bouska, A. Jochum, D. Kesireddy, M. Mahov, S. Lownik, J. Zhang, W. Lone, W. Soma, M. A. Gamboa, A. Devarkonda, V. Elgamal, D. Fariha, A. Mansoor, A. Stewart, D. Martin, P. Link, B. K. Advani, R. H. Barr, P. M. Goy, A. H. Mehta, A. Kamdar, M. Stephens, D. M. Bachanova, V. Smith, L. Morin, R. Pararajalingam, P. Lunning, M. A. Fu, K. Wiesenberger, D. Chan, W. C. Khoury, J. Greiner, T. C. Vose, J. M. Merchant, A. Bi, C. Iqbal, J. 2025-06-27 doi:10.1101/2025.06.25.661613 Cold Spring Harbor Laboratory Press 2025-06-27 <![CDATA[ Timing, movement, and reward contributions to prefrontal and striatal ramping activity ]]> https://biorxiv.org/content/10.1101/2025.07.02.662841v1?rss=1 Bova, A. Weber, M. A. Spicer, M. M. Khandelwal, V. Volkman, R. A. McMurrin, M. Kryca, J. Sivakumar, K. Kirkpatrick, B. Zhang, Q. Narayanan, N. 2025-07-03 doi:10.1101/2025.07.02.662841 Cold Spring Harbor Laboratory Press 2025-07-03 <![CDATA[ CASZ1 regulates the rate at which outer hair cells mature and is required for hearing ]]> https://biorxiv.org/content/10.1101/2025.07.04.663233v1?rss=1 Nakano, Y. Driver, E. C. Wiechert, S. C. Peguero, B. Boger, E. T. Allamargot, C. Hipp, R. Doetzlhofer, A. Morell, R. J. Kelley, M. W. Banfi, B. 2025-07-05 doi:10.1101/2025.07.04.663233 Cold Spring Harbor Laboratory Press 2025-07-05 <![CDATA[ Metagenomic polymorphic toxin effector and immunity profiling predicts microbiome development and disease-related dysbiosis ]]> https://biorxiv.org/content/10.1101/2025.07.08.662037v1?rss=1 Schroer, H. W. Beghini, F. Garay, J. A. R. Christakis, N. A. Bosch, D. E. 2025-07-08 doi:10.1101/2025.07.08.662037 Cold Spring Harbor Laboratory Press 2025-07-08 <![CDATA[ Prevenying vision loss in a mouse model of Leber Congenital Amaurosis by engineered tRNA ]]> https://biorxiv.org/content/10.1101/2025.07.10.660754v1?rss=1 Pattnaik, B. R. Akyuz, E. Shahi, P. K. Gissot, L. Saneh, A. A. Sinha, D. Hanstad, G. Kabra, M. R. Zepeda, M. A. Gamm, D. M. Young, S. M. Ahern, C. A. 2025-07-11 doi:10.1101/2025.07.10.660754 Cold Spring Harbor Laboratory Press 2025-07-11 <![CDATA[ Regulated proteolysis of green fluorescent protein fusion proteins in Aspergillus fumigatus ]]> https://biorxiv.org/content/10.1101/2025.07.14.664774v1?rss=1 Paul, S. Moye-Rowley, W. S. 2025-07-14 doi:10.1101/2025.07.14.664774 Cold Spring Harbor Laboratory Press 2025-07-14 <![CDATA[ The role of attention in the generation of anticipatory potentials to affective stimuli: an ERP and source analysis study ]]> https://biorxiv.org/content/10.1101/2025.07.10.664111v1?rss=1 Benzaquen, E. Griffiths, T. D. Kumar, S. 2025-07-15 doi:10.1101/2025.07.10.664111 Cold Spring Harbor Laboratory Press 2025-07-15 <![CDATA[ Enabling supratheoretical isopropanol yields from carbon-negative glucose fermentations with Clostridium acetobutylicum-Clostridium ljungdahlii cocultures ]]> https://biorxiv.org/content/10.1101/2025.07.14.664808v1?rss=1 Willis, N. B. Otten, J. K. Seo, H. Munasinghe, P. C. Hill, J. D. PAPOUTSAKIS, E. T. 2025-07-18 doi:10.1101/2025.07.14.664808 Cold Spring Harbor Laboratory Press 2025-07-18 <![CDATA[ Exploring neural mechanisms underlying error-related impairments in active working memory suggests an adaptive shielding of contents during cognitive control ]]> https://biorxiv.org/content/10.1101/2025.07.19.665355v1?rss=1 Choo, Y. Adam, K. C. S. Wessel, J. R. 2025-07-23 doi:10.1101/2025.07.19.665355 Cold Spring Harbor Laboratory Press 2025-07-23 <![CDATA[ Spatial transcriptomic profiling uncovers the molecular effects of the neurotoxicant polychlorinated biphenyls (PCBs) in the brains of adult mice ]]> https://biorxiv.org/content/10.1101/2025.07.24.665575v1?rss=1 Basu, B. Breese, N. M. Lombardi, S. Wang, H. Li, X. Tiburcio, D. Niemasz, Z. Beyer, S. E. Dean, L. E. Marek, R. F. Toborek, M. Lehmler, H.-J. Chatterjee, S. 2025-07-26 doi:10.1101/2025.07.24.665575 Cold Spring Harbor Laboratory Press 2025-07-26 <![CDATA[ TWITCHES DURING N2 AND N3 ARE COUPLED WITH SLEEP SPINDLES BUT NOT DELTA OSCILLATIONS IN 6-MONTH-OLD INFANTS ]]> https://biorxiv.org/content/10.1101/2025.07.23.666445v1?rss=1 Christiansen, T. G. Sokoloff, G. Long, H. C. Kopp, O. K. Karr, L. K. Blumberg, M. S. 2025-07-27 doi:10.1101/2025.07.23.666445 Cold Spring Harbor Laboratory Press 2025-07-27 <![CDATA[ Metabolic and behavioral effects of neurofibromin result from differential recruitment of MAPK and mTOR signaling ]]> https://biorxiv.org/content/10.1101/2025.07.25.666841v1?rss=1 Botero, V. Barrios, J. Knauss, A. Rosendahl, E. Colodner, K. J. Tomchik, S. M. 2025-07-30 doi:10.1101/2025.07.25.666841 Cold Spring Harbor Laboratory Press 2025-07-30 <![CDATA[ Sleep deprivation selectively reactivates hippocampal CA1 pyramidal neurons. ]]> https://biorxiv.org/content/10.1101/2025.07.30.665413v1?rss=1 View larger version (30K): org.highwire.dtl.DTLVardef@1cfa351org.highwire.dtl.DTLVardef@eb387dorg.highwire.dtl.DTLVardef@c9cf6forg.highwire.dtl.DTLVardef@1518b12_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Wang, Y. Walsh, E. N. Resch, J. M. Lyons, L. C. Abel, T. 2025-07-31 doi:10.1101/2025.07.30.665413 Cold Spring Harbor Laboratory Press 2025-07-31 <![CDATA[ Age-Related Alterations in the Expression of Mesencephalic Astrocyte-derived Neurotrophic Factor in the Brain and Their Impact on Neurobehavioral Functions ]]> https://biorxiv.org/content/10.1101/2025.07.29.667462v1?rss=1 Hu, D. Wen, W. Li, H. Zhang, Z. Lin, H. Luo, J. 2025-08-01 doi:10.1101/2025.07.29.667462 Cold Spring Harbor Laboratory Press 2025-08-01 <![CDATA[ Development of a Targeted Choroidal Injury Model for the Study of Retinal Degenerations and Therapeutic Cell Replacement ]]> https://biorxiv.org/content/10.1101/2025.07.29.667466v1?rss=1 Pandala, N. De Melo Haefeli, L. Lang, M. Stone, E. M. Tucker, B. A. Mullins, R. F. Han, I. C. 2025-08-01 doi:10.1101/2025.07.29.667466 Cold Spring Harbor Laboratory Press 2025-08-01 <![CDATA[ Maternal low-fat and high-fat diet decreases survival and alters cytokine signaling in neonatal mice with Staphylococcus epidermidis sepsis ]]> https://biorxiv.org/content/10.1101/2025.07.30.667518v1?rss=1 Bodilly, L. L. Weiner, S. Bermick, J. R. 2025-08-02 doi:10.1101/2025.07.30.667518 Cold Spring Harbor Laboratory Press 2025-08-02 <![CDATA[ Deficiency of Mesencephalic Astrocyte-derived Neurotrophic Factor Aggravates Acute Pancreatitis in Mice ]]> https://biorxiv.org/content/10.1101/2025.07.31.667953v1?rss=1 Li, H. Ma, M. Wen, W. Leidinger, M. R. Hu, D. Zhang, Z. Lin, H. Luo, J. 2025-08-02 doi:10.1101/2025.07.31.667953 Cold Spring Harbor Laboratory Press 2025-08-02 <![CDATA[ Ramping up the Heat: Induction of Systemic and Pulmonary Immune Responses and Metabolic Adaptations in Mice ]]> https://biorxiv.org/content/10.1101/2025.08.01.667768v1?rss=1 Dean, L. E. Adamcakova-Dodd, A. Lehmler, H.-J. 2025-08-02 doi:10.1101/2025.08.01.667768 Cold Spring Harbor Laboratory Press 2025-08-02 <![CDATA[ Evidence for a Transient State of Auditory Hypersensitivity During Initial Onset of Tinnitus, Evidenced by Intensity Dependence of the Auditory Evoked Potential (IDAEP) ]]> https://biorxiv.org/content/10.1101/2025.08.02.668306v1?rss=1 Umashankar, A. Alter, K. Gander, P. E. Sedley, W. 2025-08-03 doi:10.1101/2025.08.02.668306 Cold Spring Harbor Laboratory Press 2025-08-03 <![CDATA[ Metatranscriptomic analysis reveals toxin-antitoxin system shifts in caries-associated oral microbiomes ]]> https://biorxiv.org/content/10.1101/2025.08.07.669164v1?rss=1 Rajaram, S. V. Singh, P. Zeng, E. 2025-08-11 doi:10.1101/2025.08.07.669164 Cold Spring Harbor Laboratory Press 2025-08-11 <![CDATA[ Adaptive behavior is guided by integrated representations of controlled and non-controlled information ]]> https://biorxiv.org/content/10.1101/2025.08.07.669231v1?rss=1 Huang, B. Ritz, H. Jiang, J. 2025-08-11 doi:10.1101/2025.08.07.669231 Cold Spring Harbor Laboratory Press 2025-08-11 <![CDATA[ In vivo CRISPR screening links NFKB1 to endocrine resistance in ER⁺ breast cancer ]]> https://biorxiv.org/content/10.1101/2025.08.11.669793v1?rss=1 lyu, C. Hall, S. D. Stamnes, M. A. Chen, S. 2025-08-13 doi:10.1101/2025.08.11.669793 Cold Spring Harbor Laboratory Press 2025-08-13 <![CDATA[ A Practical Preprocessing Pipeline for Concurrent TMS-iEEG: Critical Steps and Methodological Considerations ]]> https://biorxiv.org/content/10.1101/2025.08.13.670238v1?rss=1 Li, Z. Liu, X. Tatz, J. Hassan, U. Wang, J. B. Keller, C. J. Trapp, N. T. Boes, A. D. Jiang, J. 2025-08-18 doi:10.1101/2025.08.13.670238 Cold Spring Harbor Laboratory Press 2025-08-18 <![CDATA[ Perceptual Novelty in Tinnitus a Causative Factor for its Persistence. A Stimulus Novelty Based P300 Paradigm on Acute, Chronic, and Non-Tinnitus Controls ]]> https://biorxiv.org/content/10.1101/2025.08.15.670598v1?rss=1 Umashankar, A. Alter, K. Gander, P. E. Sedley, W. 2025-08-18 doi:10.1101/2025.08.15.670598 Cold Spring Harbor Laboratory Press 2025-08-18 <![CDATA[ Complement contributes to hyperactive behavior in the 16p11.2 hemideletion mouse model ]]> https://biorxiv.org/content/10.1101/2025.08.21.671537v1?rss=1 Kelvington, B. A. Kim, J. Fair, R. Gaine, M. E. Abel, T. 2025-08-22 doi:10.1101/2025.08.21.671537 Cold Spring Harbor Laboratory Press 2025-08-22 <![CDATA[ Cardiac-specific Kv1.1 deficiency alters cardiomyocyte electrophysiology without modifying overall cardiac function or arrhythmia susceptibility ]]> https://biorxiv.org/content/10.1101/2025.08.25.671830v1?rss=1 Halvorson, K. Si, M. Trosclair, K. Aughenbaugh, E. Parkinson, M. Gautier-Hall, N. M. Watts, M. Kizek, F. Bhuiyan, M. S. Dominic, P. Hamilton, K. A. Glasscock, E. 2025-08-28 doi:10.1101/2025.08.25.671830 Cold Spring Harbor Laboratory Press 2025-08-28 <![CDATA[ Molecular prosthetics for CFTR designed for anion selectivity outperform amphotericin B in cultured cystic fibrosis airway epithelia ]]> https://biorxiv.org/content/10.1101/2025.08.28.671923v1?rss=1 Marin-Toledo, J. P. Greenan, D. M. Celis, N. Haske, L. Lewandowska, A. Rakowski, C. K. Shastry, S. Maji, A. Green, K. J. Pogorelov, T. V. Welsh, M. J. Thornell, I. M. Burke, M. D. 2025-08-28 doi:10.1101/2025.08.28.671923 Cold Spring Harbor Laboratory Press 2025-08-28 <![CDATA[ Lentiviral-mediated gene complementation rescues pathogenic ABCA3 variants ]]> https://biorxiv.org/content/10.1101/2025.08.29.673150v1?rss=1 Cooney, A. L. Lamer, S. Yang, P. Wenger, D. White, F. V. Cole, F. S. Wohlford-Lenane, C. L. Hennessey, E. Bawa, P. Kotton, D. N. Sinn, P. Wambach, J. A. McCray, P. B. 2025-08-30 doi:10.1101/2025.08.29.673150 Cold Spring Harbor Laboratory Press 2025-08-30 <![CDATA[ Replating induces mTOR-dependent rescue of protein synthesis in Charcot-Marie-Tooth diseased neurons ]]> https://biorxiv.org/content/10.1101/2025.08.26.672367v1?rss=1 Koenig, J. McGuire, A. Homedan, Y. Alberhasky, J. Summers, D. W. 2025-08-31 doi:10.1101/2025.08.26.672367 Cold Spring Harbor Laboratory Press 2025-08-31 <![CDATA[ Non-canonical Sodium Channel Isoforms Underlie Chamber Specific Cardiac Excitability ]]> https://biorxiv.org/content/10.1101/2025.08.27.672688v1?rss=1 Clark, C. J. Anderson, C. Dou, A. Dierdorff, J. Galpin, J. D. Gissot, L. Thompson, S. Choi, H. Yoon, J.-Y. Infield, D. T. Leeds, K. Bronk, P. McLendon, J. M. Boudreau, R. L. Choi, B.-R. London, B. Ahern, C. A. 2025-09-01 doi:10.1101/2025.08.27.672688 Cold Spring Harbor Laboratory Press 2025-09-01 <![CDATA[ The interplay between temperature and growth phase shapes the transcriptional landscape of Pseudomonas aeruginosa ]]> https://biorxiv.org/content/10.1101/2025.08.28.672984v1?rss=1 Robinson, R. E. Gebhardt, M. J. Goldberg, J. B. 2025-09-01 doi:10.1101/2025.08.28.672984 Cold Spring Harbor Laboratory Press 2025-09-01 <![CDATA[ Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice ]]> https://biorxiv.org/content/10.1101/2025.08.31.673254v1?rss=1 Calubag, M. F. Ademi, I. Green, C. L. Jayarathne, H. S. M. Manchanayake, D. N. H. Le, S. M. Lialios, P. Breuer, L. E. Yakar, S. Babygirija, R. Sonsalla, M. M. Grunow, I. Yeh, C.-Y. Liu, Y. Knopf, B. A. Ricke, W. A. Liu, T. T. Sadagurski, M. Lamming, D. W. 2025-09-04 doi:10.1101/2025.08.31.673254 Cold Spring Harbor Laboratory Press 2025-09-04 <![CDATA[ Recapitulating apicobasal tissue polarity in extracellular matrix incorporated airway organoids ]]> https://biorxiv.org/content/10.1101/2025.09.03.672699v1?rss=1 Gong, Z. Bhattaram, D. Porritt, L. Golestan, K. farimani, A. B. Ryan, A. L. Weiss, D. Ren, X. 2025-09-04 doi:10.1101/2025.09.03.672699 Cold Spring Harbor Laboratory Press 2025-09-04 <![CDATA[ Spontaneous peripheral oxygen desaturation and apnea events in mice vary by strain and inspired oxygen level ]]> https://biorxiv.org/content/10.1101/2025.09.01.673515v1?rss=1 Kalra, H. Vasileva, A. Jedlicka, C. R. Vasilyev, M. Buckman, M. A. Zhang, Z. Gehlbach, B. Liu, J. DeRuisseau, L. R. Chapleau, M. W. Breheny, P. Tomasson, M. Bates, M. 2025-09-05 doi:10.1101/2025.09.01.673515 Cold Spring Harbor Laboratory Press 2025-09-05 <![CDATA[ Genetic Deletion of ASIC3 Alters Left Ventricular Remodeling and Autonomic Function After Myocardial Infarction in Mice ]]> https://biorxiv.org/content/10.1101/2025.09.03.674120v1?rss=1 Monaghan, K. Gibbons, D. D. Ward, C. C. El-Geneidy, M. Kutschke, W. Zimmerman, K. A. Morgan, D. A. Stauss, H. M. Harding, A. M. S. Bader, M. C. Snyder, P. M. Sabharwal, R. Weiss, R. M. Rahmouni, K. Benson, C. J. 2025-09-08 doi:10.1101/2025.09.03.674120 Cold Spring Harbor Laboratory Press 2025-09-08 <![CDATA[ Multiple clades of regulators contribute to bacterial phosphate homeostasis and pathogenesis ]]> https://biorxiv.org/content/10.1101/2025.09.08.674922v1?rss=1 Vermilya, A. C. Joya, E. S. Radin, J. N. Olsen, G. J. He, B. Kehl-Fie, T. E. 2025-09-08 doi:10.1101/2025.09.08.674922 Cold Spring Harbor Laboratory Press 2025-09-08 <![CDATA[ Acute malaria dysregulates specialized lymph node macrophages to suppress vaccine-elicited protection against Ebola virus ]]> https://biorxiv.org/content/10.1101/2025.09.10.675493v1?rss=1 Elliff, J. Grady, L. O'Donnell, K. L. Messingham, C. O. Rogers, K. J. Akther, J. Thurman, A. Vijay, R. Pezzulo, A. A. Randall, T. Marzi, A. Butler, N. Maury, W. 2025-09-11 doi:10.1101/2025.09.10.675493 Cold Spring Harbor Laboratory Press 2025-09-11 <![CDATA[ Trsp is required by regulatory T cells to prevent lethal autoimmunity in mice ]]> https://biorxiv.org/content/10.1101/2025.09.09.675163v1?rss=1 Jacobse, J. Pilat, J. M. Harris, A. B. Kwag, A. Aziz, Z. Chi, C. Schaefer, S. Neely, M. D. Buendia, M. A. Pahnke, A. Williams, C. S. Deng, W. Washington, M. K. Rathmell, J. Flynn, C. R. Rings, E. H. Short, S. P. Prabhu, K. S. Samsom, J. N. Goettel, J. A. Choksi, Y. A. 2025-09-15 doi:10.1101/2025.09.09.675163 Cold Spring Harbor Laboratory Press 2025-09-15 <![CDATA[ Long non-coding RNA Cerox1 targets components of the mitochondrial electron transport chain to regulate the memory impairment caused by sleep deprivation ]]> https://biorxiv.org/content/10.1101/2025.09.15.676326v1?rss=1 View larger version (48K): org.highwire.dtl.DTLVardef@6d72d5org.highwire.dtl.DTLVardef@18e3590org.highwire.dtl.DTLVardef@15e83c9org.highwire.dtl.DTLVardef@1e1f92_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Ravichandran, K. Kisku, P. Ningchangmi, L. Palanisamy, P. Strack, S. Abel, T. Banerjee, S. 2025-09-17 doi:10.1101/2025.09.15.676326 Cold Spring Harbor Laboratory Press 2025-09-17 <![CDATA[ Novel monoclonal antibodies against the C-terminal HEAT domain of Huntingtin ]]> https://biorxiv.org/content/10.1101/2025.09.17.676860v1?rss=1 Park, Y.-N. Fanti, R. Sadeghi, S. Chandrasekaran, R. Edwards, A. Harding, R. J. Houston, D. W. 2025-09-17 doi:10.1101/2025.09.17.676860 Cold Spring Harbor Laboratory Press 2025-09-17 <![CDATA[ Model-based and model-free valuation signals in the human brain vary markedly in their relationship to individual differences in behavioral control ]]> https://biorxiv.org/content/10.1101/2025.09.17.676398v1?rss=1 Ding, W. Cockburn, J. Simon, J. P. Johri, A. Cho, S. J. Oh, S. Feusner, J. D. Tadayonnejad, R. O'Doherty, J. P. 2025-09-19 doi:10.1101/2025.09.17.676398 Cold Spring Harbor Laboratory Press 2025-09-19 <![CDATA[ Interdomain disulfide bonds of rabbit kappa light chain allotypes influence mouse-rabbit chimeric antibody performance ]]> https://biorxiv.org/content/10.1101/2025.09.17.676883v1?rss=1 Park, Y.-N. Houston, D. W. 2025-09-20 doi:10.1101/2025.09.17.676883 Cold Spring Harbor Laboratory Press 2025-09-20 <![CDATA[ NanoDel: a long-read sequencing pipeline for identifying large-scale mitochondrial DNA deletions validated in patient samples clinically diagnosed with mitochondrial disease and evaluated in glioblastoma. ]]> https://biorxiv.org/content/10.1101/2025.09.19.677263v1?rss=1 Fearn, C. Oliva, C. Griguer, C. Poulton, J. Fratter, C. McGeehan, J. Baldock, R. Robson, S. McGeehan, R. 2025-09-21 doi:10.1101/2025.09.19.677263 Cold Spring Harbor Laboratory Press 2025-09-21 <![CDATA[ Candida albicans infiltrates colon and rectal cancers causing therapeutic resistance and decreased survival ]]> https://biorxiv.org/content/10.1101/2025.09.19.677366v1?rss=1 Grencewicz, D. J. Loncar, A. Ferrandon, S. Chatterjee, D. Kreamer, M. Mehra, Y. Carson, A. Hoyd, R. Jahanbakhshi, S. Choueiry, F. Anderson, M. Z. Benej, M. Bosch, D. E. Zhu, J. Wu, J. Pallerla, A. Bocklage, T. McCarter, M. Tarhini, A. Salhia, B. Moskaluk, C. Riedlingeer, G. Yao, S. Masood, A. Hardikar, S. Ilozumba, M. Ulrich, C. M. Chan, C. H. F. Shiver, C. George, S. Mudaranthakam, D. P. Churchman, M. Rounbehler, R. Chambers, L. Carbone, D. Kalady, M. F. Denko, N. Spakowicz, D. 2025-09-21 doi:10.1101/2025.09.19.677366 Cold Spring Harbor Laboratory Press 2025-09-21 <![CDATA[ Fast segmentation with the NextBrain histological atlas ]]> https://biorxiv.org/content/10.1101/2025.09.22.673638v1?rss=1 Puonti, O. Nolan, J. Dicamillo, R. Balbastre, Y. Casamitjana, A. Mancini, M. Robinson, E. Peter, L. Annunziata, R. Althonayan, J. Crampsie, S. Blackburn, E. Billot, B. Atzeni, A. Schmidt, P. Hughes, J. Augustinack, J. Edlow, B. L. Zöllei, L. Thomas, D. Kliemann, D. Bocchetta, M. Strand, C. Holton, J. Jaunmuktane, Z. Iglesias, J. E. 2025-09-25 doi:10.1101/2025.09.22.673638 Cold Spring Harbor Laboratory Press 2025-09-25 <![CDATA[ A hypothalamic circuit for anticipating future changes in energy balance. ]]> https://biorxiv.org/content/10.1101/2025.09.27.678865v1?rss=1 Walker, S. J. Lowenstein, E. D. Douglass, A. M. Madara, J. C. Resch, J. M. Tao, J. Lowell, B. B. 2025-09-28 doi:10.1101/2025.09.27.678865 Cold Spring Harbor Laboratory Press 2025-09-28 <![CDATA[ Temporal Dynamics of Flexible Cognitive Control ]]> https://biorxiv.org/content/10.1101/2025.10.03.680146v1?rss=1 Wu, C. Seger, C. A. Luo, C. Zhou, Y. Jiang, J. Chen, Q. 2025-10-03 doi:10.1101/2025.10.03.680146 Cold Spring Harbor Laboratory Press 2025-10-03 <![CDATA[ Modeling MEK-inhibitor Associated Retinopathy in vitro using human induced-1 pluripotent stem cell-derived retinal pigment epithelial cells ]]> https://biorxiv.org/content/10.1101/2025.10.03.680301v1?rss=1 Lozano, L. P. Jennisch, M. Jensen, R. Ratcliff, J. A. Wiley, L. A. Harman, B. Riker, M. J. Wright, A. T. Erickson, B. A. Boldt, H. C. Boyce, T. M. Mullins, R. Binkley, E. M. Tucker, B. A. 2025-10-04 doi:10.1101/2025.10.03.680301 Cold Spring Harbor Laboratory Press 2025-10-04 <![CDATA[ NPS neurons receive extensive input from auditory brainstem nuclei ]]> https://biorxiv.org/content/10.1101/2025.10.08.681223v1?rss=1 Zhang, R. Geerling, J. C. 2025-10-09 doi:10.1101/2025.10.08.681223 Cold Spring Harbor Laboratory Press 2025-10-09 <![CDATA[ Effect of fluid control on the affective state of laboratory macaques ]]> https://biorxiv.org/content/10.1101/2025.10.10.681594v1?rss=1 Castellano Bueno, J. Paraskevopoulou, A. Miller, C. W. Petkov, C. Schmid, M. C. Thiele, A. Bateson, M. Poirier, C. 2025-10-10 doi:10.1101/2025.10.10.681594 Cold Spring Harbor Laboratory Press 2025-10-10 <![CDATA[ Systematic elucidation and pharmacologic targeting on non-oncogene dependencies in imatinib-resistant gastrointestinal stromal tumor ]]> https://biorxiv.org/content/10.1101/2025.10.12.681609v1?rss=1 Mundi, P. S. Grunn, A. Kojadinovic, A. Karan, C. Realubit, R. Caescu, I. C. Hibshoosh, H. Aburi, M. Alvarez, M. J. Ingham, M. Evans, D. Rothschild, S. Schwartz, G. K. Califano, A. 2025-10-14 doi:10.1101/2025.10.12.681609 Cold Spring Harbor Laboratory Press 2025-10-14 <![CDATA[ Deep Learning of Brain-Behavior Dimensions Identifies Transdiagnostic Biotypes in Youth with ADHD and Anxiety Disorders ]]> https://biorxiv.org/content/10.1101/2025.10.13.682243v1?rss=1 Jiao, Y. Tong, X. Fonzo, G. A. Gotlib, I. H. Pohl, K. M. Satterthwaite, T. D. Jiang, J. Zhang, Y. 2025-10-15 doi:10.1101/2025.10.13.682243 Cold Spring Harbor Laboratory Press 2025-10-15 <![CDATA[ Selective reduction of KCNA4 in vulnerable glutamatergic-serotonin neurons of the dorsal raphe nucleus in Alzheimers Disease ]]> https://biorxiv.org/content/10.1101/2025.10.17.683113v1?rss=1 Kolling, L. J. Balasubramanian, N. Ismail, S. Feller, A. J. Hunter Alberhasky, J. M. Wang, R. Jennings, L. Hefti, M. Marcinkiewcz, C. A. 2025-10-22 doi:10.1101/2025.10.17.683113 Cold Spring Harbor Laboratory Press 2025-10-22 <![CDATA[ Bayesian Cooperative Learning for Multimodal Integration ]]> https://biorxiv.org/content/10.1101/2025.10.23.684056v1?rss=1 Roy, S. Sarkar, S. Paul, E. Basak, P. Yi, N. Mallick, H. 2025-10-23 doi:10.1101/2025.10.23.684056 Cold Spring Harbor Laboratory Press 2025-10-23 <![CDATA[ SAMHD1 promotes SARS-CoV-2 infection by enhancing HNF1-dependent ACE2 expression in lung epithelial cells ]]> https://biorxiv.org/content/10.1101/2025.10.23.684143v1?rss=1 Cheung, P.-H. H. Chan, P. Yang, H. Honne, S. Kim, B. Perlman, S. Wu, L. 2025-10-24 doi:10.1101/2025.10.23.684143 Cold Spring Harbor Laboratory Press 2025-10-24 <![CDATA[ A metalloenzyme's metal preference evolves through redox modulation driven by the cofactor's secondary coordination sphere ]]> https://biorxiv.org/content/10.1101/2025.10.23.684290v1?rss=1 Mackenzie, E. S. Sendra, K. M. Basle, A. Mazgaj, R. Kehl-Fie, T. E. Waldron, K. J. 2025-10-24 doi:10.1101/2025.10.23.684290 Cold Spring Harbor Laboratory Press 2025-10-24 <![CDATA[ Directing fratricide within T cell products using an anti-uPAR chimeric antigen receptor to drive the production of potent therapeutic cells ]]> https://biorxiv.org/content/10.1101/2025.10.24.684419v1?rss=1 View larger version (27K): org.highwire.dtl.DTLVardef@199d85forg.highwire.dtl.DTLVardef@14c638aorg.highwire.dtl.DTLVardef@1b3322org.highwire.dtl.DTLVardef@1ba253d_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Sarko, L. Givand, D. Shepley, C. Rattin, B. Attar, A. Taylor, R. Kutler, B. Traynor, R. M. Upadhyaya, A. Mnuk, M. Gehrke, C. Murren, N. Ulland, T. Kotanchek, T. Saha, K. 2025-10-25 doi:10.1101/2025.10.24.684419 Cold Spring Harbor Laboratory Press 2025-10-25 <![CDATA[ Enhancing HIPEC for Ovarian Cancer using Adjunctive Biomaterials ]]> https://biorxiv.org/content/10.1101/2025.10.26.684645v1?rss=1 Bi, J. Witt, E. Cafi, A. B. Shu, F. McGovern, M. Tunuguntla, S. N. S. Balk, K. R. Boge, L. Wang, Q. Du, J. Sutton, I. C. Reis, C. J. Spreng, J. M. Elizalde, E. Uzomah, U. Traverso, G. Otterbein, L. E. Byrne, J. 2025-10-27 doi:10.1101/2025.10.26.684645 Cold Spring Harbor Laboratory Press 2025-10-27 <![CDATA[ Ventral tegmental area dopamine controls timing variability ]]> https://biorxiv.org/content/10.1101/2025.10.27.684913v1?rss=1 Weber, M. A. Sivakumar, K. Bova, A. Tabakovic, E. Conlon, M. Oya, M. Singh, A. Cole, R. Espinoza, A. Kim, Y. Narayanan, N. 2025-10-28 doi:10.1101/2025.10.27.684913 Cold Spring Harbor Laboratory Press 2025-10-28 <![CDATA[ mRNA vaccination overcomes hemozoin-mediated impairment of whole parasite vaccine efficacy for malaria ]]> https://biorxiv.org/content/10.1101/2025.10.29.685344v1?rss=1 Hassert, M. Drewry, L. L. Pewe, L. L. Hancox, L. S. He, R. Arumugam, S. Mix, M. R. Salem, A. K. Harty, J. T. 2025-10-29 doi:10.1101/2025.10.29.685344 Cold Spring Harbor Laboratory Press 2025-10-29 <![CDATA[ The LINC complex and microtubule motors regulate the number and position of nuclei in the subperineurial glial cells of the Drosophila blood-brain barrier ]]> https://biorxiv.org/content/10.1101/2025.10.29.685339v1?rss=1 Annes, O. R. Schmitt, A. Akinremi, D. B. Koskas, D. Qiu, Y. Jewell, H. DaCosta, J. M. Folker, E. 2025-10-30 doi:10.1101/2025.10.29.685339 Cold Spring Harbor Laboratory Press 2025-10-30 <![CDATA[ Position-dependent effects of SCN2A premature stop codons on neuronal excitability and behavior ]]> https://biorxiv.org/content/10.1101/2025.10.30.685422v1?rss=1 Al Saneh, A. Arrieta, M. F. H. Gissot, L. O'Bryan, M. Li, R. Buchanan, G. F. Ahern, C. A. Williams, A. J. 2025-10-31 doi:10.1101/2025.10.30.685422 Cold Spring Harbor Laboratory Press 2025-10-31 <![CDATA[ Impact of N6-methyladenosine (m6A) machinery on HIV-1 replication in primary CD4+ T cells ]]> https://biorxiv.org/content/10.1101/2025.11.07.686373v1?rss=1 Jackson-Jones, K. A. Simons, L. M. Huang, S. Joseph, T. Sawyer, A. Wu, L. Hultquist, J. F. 2025-11-08 doi:10.1101/2025.11.07.686373 Cold Spring Harbor Laboratory Press 2025-11-08 <![CDATA[ Psychiatric risk implications of adolescent exposure to environmental insecticides: a systematic review of rodent studies ]]> https://biorxiv.org/content/10.1101/2025.11.06.687006v1?rss=1 Chen, M. X. Hing, B. Taylor, R. J. Stevens, H. E. 2025-11-10 doi:10.1101/2025.11.06.687006 Cold Spring Harbor Laboratory Press 2025-11-10 <![CDATA[ Pupil dilation indexes - but does not causally influence - conscious error detection: a double-blind, placebo-controlled investigation of performance-monitoring using atomoxetine. ]]> https://biorxiv.org/content/10.1101/2025.11.07.687236v1?rss=1 Choo, Y. Segal, A. E. Carnahan, R. M. Chalkley, N. Potter, R. Dolan, K. Nickl-Jockschat, T. Wessel, J. R. 2025-11-10 doi:10.1101/2025.11.07.687236 Cold Spring Harbor Laboratory Press 2025-11-10 <![CDATA[ Brain-wide single-neuron bases of working memory for sounds in humans ]]> https://biorxiv.org/content/10.1101/2025.11.10.687666v1?rss=1 Berger, J. I. Billig, A. J. Gander, P. E. Kovach, C. K. Rhone, A. E. Calmus, R. M. Garcia, C. M. Kumar, S. Kawasaki, H. Howard, M. A. Griffiths, T. D. 2025-11-11 doi:10.1101/2025.11.10.687666 Cold Spring Harbor Laboratory Press 2025-11-11 <![CDATA[ The L-lactate dehydrogenase LldD contributes to oxidative stress resistance, survival from neutrophils, and host colonization in Neisseria gonorrhoeae ]]> https://biorxiv.org/content/10.1101/2025.11.17.688940v1?rss=1 Lankford, J. Barr, W. Andersen, C. Karuppiah, A. Thomas, K. S. Glomski, I. Criss, A. K. Potter, A. D. 2025-11-17 doi:10.1101/2025.11.17.688940 Cold Spring Harbor Laboratory Press 2025-11-17 <![CDATA[ The HosA histone deacetylase regulates stress resistance, host cell interactions, and virulence in Aspergillus fumigatus ]]> https://biorxiv.org/content/10.1101/2025.11.19.689210v1?rss=1 Liu, H. Lee, P. Vo, A. Paul, S. Phan, Q. T. Lin, J. Bruno, V. M. Stamnes, M. A. Moye-Rowley, W. S. Filler, S. G. 2025-11-19 doi:10.1101/2025.11.19.689210 Cold Spring Harbor Laboratory Press 2025-11-19 <![CDATA[ A SARS-CoV-2 entry inhibitor trimerizes to lock the spike protein in a closed conformation ]]> https://biorxiv.org/content/10.1101/2025.11.19.689107v1?rss=1 Mou, H. Gao, B. Ye, G. Zhang, L. Saxena, D. Bu, F. Vishwakarma, J. Zhou, S. Bayona, C. R. Li, L. Getmanenko, Y. Bhandari, J. Bailey, C. C. Crynen, G. C. Kitzmiller, C. E. Li, H. Otsuka, Y. Wang, C. Batra, L. Weston, S. Frieman, M. B. Meyerholz, D. K. Scampavia, L. Spicer, T. Harris, R. S. Cameron, M. Bannister, T. Zheng, J. Farzan, M. Li, F. Choe, H. 2025-11-20 doi:10.1101/2025.11.19.689107 Cold Spring Harbor Laboratory Press 2025-11-20 <![CDATA[ PlantCV v4: Image analysis software for high-throughput plant phenotyping ]]> https://biorxiv.org/content/10.1101/2025.11.19.689271v1?rss=1 Schuhl, H. Brown, K. E. Sheng, H. Bhatt, P. K. Gutierrez, J. Schneider, D. Casto, A. L. Acosta-Gamboa, L. Ballenger, J. G. Barbero, F. Braley, J. Brown, A. M. Chavez, L. Cunningham, S. Dilhara, M. Dimech, A. M. Duenwald, J. G. Fischer, A. Gordon, J. M. Hendrikse, C. Hernandez, G. L. Hodge, J. G. Huber, M. Hurr, B. M. Jarolmasjed, S. Medina Jimenez, K. Kenney, S. Konkel, G. Kutschera, A. Lama, S. Lohbihler, M. Lorence, A. Luebbert, C. Ly, N. Manching, H. K. Marrano, A. Meerdink, S. Miklave, N. M. Mudrageda, P. Murphy, K. M. Peery, J. D. Pierik, R. Polyd 2025-11-20 doi:10.1101/2025.11.19.689271 Cold Spring Harbor Laboratory Press 2025-11-20 <![CDATA[ Acute Stress in Female Adolescent Rats Increases Anxiety-like but not Depression-like Behaviors ]]> https://biorxiv.org/content/10.1101/2025.11.20.689244v1?rss=1 Xiong, J. Giannakou, I. O'Bryan, M. Hartman, C. Rempel-Clower, N. 2025-11-21 doi:10.1101/2025.11.20.689244 Cold Spring Harbor Laboratory Press 2025-11-21 <![CDATA[ Distributed activity in the human posterior putamen distinguishes goal-directed from habitual control in humans ]]> https://biorxiv.org/content/10.1101/2025.11.26.690863v1?rss=1 Johri, A. Kluen, L. M. Gera, R. Man, V. Perez, O. D. Simon, J. P. Ding, W. Fransen, A. Cho, S. Oh, S. Cockburn, J. Feusner, J. Tadayon-Nejad, R. O'Doherty, J. 2025-11-28 doi:10.1101/2025.11.26.690863 Cold Spring Harbor Laboratory Press 2025-11-28 <![CDATA[ Cryptococcus neoformans adapts to host CO2 concentrations through the coordinated remodeling of central carbon metabolism, oxidative stress resistance, and membrane homeostasis. ]]> https://biorxiv.org/content/10.1101/2025.11.28.691145v1?rss=1 Ristow, L. J. Blackburn, E. E. jezewski, a. J. Lin, X. Krysan, D. J. 2025-11-29 doi:10.1101/2025.11.28.691145 Cold Spring Harbor Laboratory Press 2025-11-29 <![CDATA[ Tripartite AAV Systems for EYS Retinal Gene Therapy ]]> https://biorxiv.org/content/10.64898/2025.12.03.692187v1?rss=1 Rhee, K.-D. Datta, P. Baccam, C. Seo, S. 2025-12-05 doi:10.64898/2025.12.03.692187 Cold Spring Harbor Laboratory Press 2025-12-05 <![CDATA[ A transient feature of the inferior olive supports thedevelopment of cerebellar internal models ]]> https://biorxiv.org/content/10.64898/2025.12.06.692744v1?rss=1 Richardson, A. M. Sokoloff, G. Blumberg, M. S. 2025-12-10 doi:10.64898/2025.12.06.692744 Cold Spring Harbor Laboratory Press 2025-12-10 <![CDATA[ Distinct Temporal Patterns of Human Neural Firing in the Subthalamic Nucleus During Speech and Orofacial Movement ]]> https://biorxiv.org/content/10.64898/2025.12.11.693637v1?rss=1 View larger version (27K): org.highwire.dtl.DTLVardef@1ec3c60org.highwire.dtl.DTLVardef@6fe46forg.highwire.dtl.DTLVardef@1fe733corg.highwire.dtl.DTLVardef@3f736b_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> Jourahmad, Z. Kovach, C. K. Rohl, A. H. Berger, J. I. Tjaden, K. Greenlee, J. D. 2025-12-13 doi:10.64898/2025.12.11.693637 Cold Spring Harbor Laboratory Press 2025-12-13 <![CDATA[ Molecular basis of noncanonical complement C3 activation by histamine ]]> https://biorxiv.org/content/10.64898/2025.12.13.694092v1?rss=1 Fernandez, F. J. de la Paz-Garcia, K. Querol-Garcia, J. Ramos-Guzman, C. A. Martin-Merinero, H. Mares-Mejia, I. Alfonso-Gonzalez, L. Rodriguez de Cordoba, S. Tunon, I. Vega, M. C. 2025-12-14 doi:10.64898/2025.12.13.694092 Cold Spring Harbor Laboratory Press 2025-12-14 <![CDATA[ The role of MICOS in modulating mitochondrial dynamics and structural changes in vulnerable regions of Alzheimer's Disease ]]> https://biorxiv.org/content/10.64898/2025.12.13.693635v1?rss=1 Shao, B. Kula, B. Le, H. Venkhatesh, P. Katti, P. Marshall, A. G. Chittaranjan, S. Thapilyal, S. Kalpana, N. Nivedya, C. Roszczyk, A. Mobley, H. Killion, M. St. John, E. Martin, P. Rodrigiuez, B. Hamilton, M. Bell, L. Wyckoff, S. Moran, L. A. Philips, M. Hubert, D. Tomeau, B. Afolabi, J. M. Kirabo, A. Blanco, I. Reasonover, S. Drake, L. E. Lippmann, E. S. Evans, C. Santisteban, M. M. Cheairs, T. G. Mesenga, S. Wanjalla, C. Gaddy, J. McMillan, R. Perez, C. P. H. Paing, H. H. Schafer, J. C. Mobley, B. Berry, J. Crabtree, A. Kovtun, O. Goodwin, S. Lopez 2025-12-16 doi:10.64898/2025.12.13.693635 Cold Spring Harbor Laboratory Press 2025-12-16 <![CDATA[ Temporal single-cell profiling uncovers age-associated delays in immune resolution to respiratory viral infection ]]> https://biorxiv.org/content/10.64898/2025.12.15.694321v1?rss=1 Sun, J. Wu, Y. Li, C. Tang, J. Gao, X. Cheon, I. S. Zhu, B. Zhang, R. Fain, C. Hu, S. Narasimhan, H. de Almeida Santos, G. Ayasoufi, K. Johnson, A. Zong, H. Zang, C. Dong, H. 2025-12-17 doi:10.64898/2025.12.15.694321 Cold Spring Harbor Laboratory Press 2025-12-17 <![CDATA[ β-Coronavirus Nsp6 hijacks host ER translocation machineries into viral replication centers ]]> https://biorxiv.org/content/10.64898/2025.12.16.694738v1?rss=1 Ecklund, K. H. Abrisch, R. G. Perlman, S. Voeltz, G. K. 2025-12-18 doi:10.64898/2025.12.16.694738 Cold Spring Harbor Laboratory Press 2025-12-18 <![CDATA[ Mind the gap: Understanding discordance between culture- and a non-culture-based measure of bacterial burden in murine tuberculosis treatment models ]]> https://biorxiv.org/content/10.64898/2025.12.18.695164v1?rss=1 500,000-times more). The two-population model suggested that the fraction of the CFU-16S gap attributable to residual 16S rRNA from dead Mtb is modest and decreases over time. After treatment, 16S rRNA often fell while CFU rose. Four-week CFU change explained most variation in relapse (R{superscript 2}=0.90) while four-week 16S rRNA change did not (R{superscript 2}=0.24). CFU-16S gap is only partially explained by slow decay of residual 16S, suggesting development of a VBNCSA population. However, continued decrease in 16S rRNA after treatment cessation and its limited association with relapse suggests VBNCSA may be a transient rather than persistent state. ]]> Tabor, S. T. Friesen, A. D. Reichlen, M. J. Dide-Agossou, C. McGrath, M. Peterson, R. Ganusov, V. V. Robertson, G. T. Voskuil, M. I. Walter, N. D. 2025-12-18 doi:10.64898/2025.12.18.695164 Cold Spring Harbor Laboratory Press 2025-12-18 <![CDATA[ Transcranial ultrasound stimulation selectively enhances fronto-temporal context-guided memory ]]> https://biorxiv.org/content/10.64898/2025.12.19.695543v1?rss=1 Slater, B. J. A. Caffaratti, H. Kaiser, M. Sallet, J. Degenaar, P. Easton, A. Kikuchi, Y. Griffiths, T. Petkov, C. 2025-12-22 doi:10.64898/2025.12.19.695543 Cold Spring Harbor Laboratory Press 2025-12-22 <![CDATA[ Treatment of Huntington's disease with a pan-HTT-targeting CRISPR nuclease ]]> https://biorxiv.org/content/10.64898/2025.12.20.695720v1?rss=1 Tan, K. Del Bosque Siller, D. Xiong, A. Y. Wang, A. X. A. McCallister, T. X. Mummadi, S. St John, L. A. Lee, T. K. Carrillo, A. Renshaw, D. G. Zhou, R. H. Lim, C. K. W. He, J. Fields, C. J. Hayden, M. R. Gaj, T. 2025-12-22 doi:10.64898/2025.12.20.695720 Cold Spring Harbor Laboratory Press 2025-12-22 <![CDATA[ Acriflavine delivery via Polyurethane nanocapsules to treat neovascular age-related macular degeneration ]]> https://biorxiv.org/content/10.64898/2025.12.22.695712v1?rss=1 Pandala, N. De Melo Haefeli, L. Khan, A. H. Steffan, H. Miller, J. Stone, E. M. Han, I. Lavik, E. Mullins, R. Tucker, B. A. 2025-12-24 doi:10.64898/2025.12.22.695712 Cold Spring Harbor Laboratory Press 2025-12-24 <![CDATA[ Antigen-specific CD8 T cells are generated and reactivated in the bone marrow following viral brain infections and impact the bone marrow niche ]]> https://biorxiv.org/content/10.64898/2025.12.25.696510v1?rss=1 Anani-Wolf, D. M. Hotchkiss, K. M. Reesman, R. A. Pfaller, C. K. Moelker, E. M. Hoyt-Miggelbrink, A. M. Fain, C. E. Blethen, K. E. Norberg, P. K. Wallace, S. E. Jain, V. Grant, G. A. Khasraw, M. Chandramohan, V. Johnson, A. J. Ayasoufi, K. 2025-12-26 doi:10.64898/2025.12.25.696510 Cold Spring Harbor Laboratory Press 2025-12-26 <![CDATA[ Diet-Related Molecular Evolution Differs between Vertivores, Invertivores, and Combined Carnivores ]]> https://biorxiv.org/content/10.64898/2025.12.30.697105v1?rss=1 Tene, M. Foley, K. Seaver, A. Meyer, W. 2025-12-31 doi:10.64898/2025.12.30.697105 Cold Spring Harbor Laboratory Press 2025-12-31 <![CDATA[ Regenerative Index reveals declining muscle regeneration in paediatric patients with Duchenne muscular dystrophy ]]> https://biorxiv.org/content/10.64898/2026.01.05.697715v1?rss=1 Smid, J. K. McPherson, C. A. Monast, J. G. Rayagiri, S. S. Moore, S. A. Rudnicki, M. A. 2026-01-05 doi:10.64898/2026.01.05.697715 Cold Spring Harbor Laboratory Press 2026-01-05 <![CDATA[ Reactive Astrocytes Drive Extracellular Acidification to Mediate α-Synuclein Neurodegeneration ]]> https://biorxiv.org/content/10.64898/2026.01.06.697893v1?rss=1 Song, J.-J. Park, H. Choi, Y. Ryu, T. Shin, J. Kim, S.-H. Park, A. Wang, J. Biswas, D. Chou, S.-C. Ha, S. Jang, Y. Shin, Y. Chen, G. Hong, I. Wemmie, J. Svenningsson, P. Troncoso, J. Xu, J. Na, C. H. Dawson, V. L. Dawson, T. Kam, T.-I. 2026-01-07 doi:10.64898/2026.01.06.697893 Cold Spring Harbor Laboratory Press 2026-01-07 <![CDATA[ ATGL-mediated lipid droplet lipolysis promotes collective migration in Drosophila ]]> https://biorxiv.org/content/10.64898/2026.01.06.697938v1?rss=1 Wipf, I. J. Lowden, E. J. Dorale, J. R. Godfredsen, K. F. Giedt, M. S. Tootle, T. L. 2026-01-08 doi:10.64898/2026.01.06.697938 Cold Spring Harbor Laboratory Press 2026-01-08 <![CDATA[ Cribriform Plate Microenvironment Assembles a Suppressive Myeloid Network during EAE-induced Neuroinflammation ]]> https://biorxiv.org/content/10.64898/2026.01.07.698165v1?rss=1 Laaker, C. Hsu, M. Madrid, A. Port, J. Vrba, S. M. Herbath, M. Baenen, C. Kumar, M. Priyathilaka, T. T. Sandor, M. Fabry, Z. 2026-01-08 doi:10.64898/2026.01.07.698165 Cold Spring Harbor Laboratory Press 2026-01-08 <![CDATA[ Transcriptomic shift in ethanol and amino acid metabolic genes regulated by Med15 during alcoholic fermentation ]]> https://biorxiv.org/content/10.64898/2026.01.08.698492v1?rss=1 Cooper, D. G. Grunkemeyer, E. Fassler, J. S. 2026-01-09 doi:10.64898/2026.01.08.698492 Cold Spring Harbor Laboratory Press 2026-01-09 <![CDATA[ New paradigm of CRISPR spacerome for classification of global Escherichia coli lineages ]]> https://biorxiv.org/content/10.64898/2026.01.12.698643v1?rss=1 Shin, H. Rajaram, S. V. Singh, P. Zeng, E. Cwiertny, D. Mattes, T. Pentella, M. Nelson, M. Jepson, R. Thompson, D. 2026-01-12 doi:10.64898/2026.01.12.698643 Cold Spring Harbor Laboratory Press 2026-01-12 <![CDATA[ Twitching in sleeping premature infants provides a sensitive behavioral assay of early motor control ]]> https://biorxiv.org/content/10.64898/2026.01.15.699697v1?rss=1 Sokoloff, G. Christiansen, T. 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A. 2026-01-18 doi:10.64898/2026.01.16.700013 Cold Spring Harbor Laboratory Press 2026-01-18 <![CDATA[ In Utero CFTR Modulation Alleviates Disease in G551D Cystic Fibrosis Pigs ]]> https://biorxiv.org/content/10.64898/2026.01.20.698888v1?rss=1 Ernst, S. E. Meyerholz, D. K. Samuel, M. S. Whitworth, K. M. Naguib, Y. W. Nakhla, D. S. Abou Alaiwa, M. H. Randak, C. O. Dong, Q. Ostedgaard, L. S. Rehman, T. Hilkin, B. M. Powers, L. S. Stroik, M. R. Gansemer, N. D. Rector, M. R. Taft, P. J. Hedinger, R. Goodell, B. J. Mather, S. E. Sen, R. Thornell, I. M. Bullard, S. A. Cecil, R. F. Benne, J. A. Ash, J. J. Boyken, L. D. Karp, P. H. Tan, P. Wu, S. Fischer, A. J. Cooney, A. L. Sinn, P. L. Pezzulo, A. A. Lee, K. McCray, P. B. Zabner, J. Salem, A. K. Prather, R. S. Welsh, M. J. Stoltz, D. A. 2026-01-21 doi:10.64898/2026.01.20.698888 Cold Spring Harbor Laboratory Press 2026-01-21 <![CDATA[ Cortico-basal ganglia dynamics of global and selective response inhibition in humans ]]> https://biorxiv.org/content/10.64898/2026.01.20.700500v1?rss=1 Soh, C. Hervault, M. Chalkley, N. Huynh, K. Zhang, Q. Uc, E. Greenlee, J. Wessel, J. R. 2026-01-21 doi:10.64898/2026.01.20.700500 Cold Spring Harbor Laboratory Press 2026-01-21 <![CDATA[ Hierarchical Reconfiguration of Neurocognitive Task Set Representations Mediates Cognitive Flexibility ]]> https://biorxiv.org/content/10.64898/2026.01.20.700694v1?rss=1 Leach, S. C. Chen, X. Hwang, K. 2026-01-21 doi:10.64898/2026.01.20.700694 Cold Spring Harbor Laboratory Press 2026-01-21 <![CDATA[ Neuronal microscale biophysical instability mediates macroscale network dynamics shaping pathological manifestations ]]> https://biorxiv.org/content/10.64898/2026.01.20.697254v1?rss=1 Kumar, V. Sanchez Franco, V. M. Ferry, F. S. Xie, Y. Hutson, A. N. Zhang, Y. J. Daniels, S. D. Nguyen, D. L. Spera, L. K. Snyder, E. M. Knauss, A. Sudhakar, S. L. Duan, G. Y. Paul, E. M. Tabuchi, M. 2026-01-22 doi:10.64898/2026.01.20.697254 Cold Spring Harbor Laboratory Press 2026-01-22 <![CDATA[ Conformalized Multiview Learning ]]> https://biorxiv.org/content/10.64898/2026.01.22.700165v1?rss=1 Roy, S. Sarkar, S. Banerjee, C. Paul, E. Basak, P. Mallick, H. 2026-01-24 doi:10.64898/2026.01.22.700165 Cold Spring Harbor Laboratory Press 2026-01-24 <![CDATA[ Intestinal Barrier Loss Enables Microbiota-Mediated Purinergic Suppression During Malaria ]]> https://biorxiv.org/content/10.64898/2026.01.22.701153v1?rss=1 Polidoro, R. B. Bednarski, O. J. Lehman, S. Oliveira, F. M. S. Fusco, E. M. Bower, L. K. Rangel-Ferreira, M. Kour, S. Namazzi, R. Opoka, R. O. John, C. C. Brault, J. Tilston-Lunel, A. Alves-Filho, J. C. Schmidt, N. W. 2026-01-24 doi:10.64898/2026.01.22.701153 Cold Spring Harbor Laboratory Press 2026-01-24 <![CDATA[ Targeting Circulating FABP4 Ameliorates Obesity-Associated Hepatic Steatosis ]]> https://biorxiv.org/content/10.64898/2026.01.24.701451v1?rss=1 View larger version (61K): org.highwire.dtl.DTLVardef@5b91d5org.highwire.dtl.DTLVardef@1c34892org.highwire.dtl.DTLVardef@1d17ea9org.highwire.dtl.DTLVardef@d2b43c_HPS_FORMAT_FIGEXP M_FIG C_FIG HighlightsO_LIHepatocytic accumulation of extrinsic FABP4 links adiposity to liver lipid deposition. C_LIO_LISpecific deletion of FABP4 in adipocytes prevents hepatic steatosis without affecting systemic lipid levels or obesity. C_LIO_LICirculating FABP4 derived from adipocytes directly binds hepatocytes to facilitate free fatty acid transfer. C_LIO_LIBlocking circulating FABP4 with a high-affinity anti-FABP4 monoclonal antibody inhibits hepatocyte lipid uptake and attenuates steatosis in multiple obese mouse models. C_LI ]]> Jiang, X. Avellino, A. Yu, J. Liu, S. Wang, Z. Han, X. Thakkar, H. Shilyansky, J. Xu, Z. Schnicker, N. Chaurasia, B. Hao, J. Sugg, S. L. Li, B. 2026-01-26 doi:10.64898/2026.01.24.701451 Cold Spring Harbor Laboratory Press 2026-01-26 <![CDATA[ Actuation of CRP activating region 3 by acetylation modulates V. cholerae sugar utilization and virulence ]]> https://biorxiv.org/content/10.64898/2026.01.27.701997v1?rss=1 Santos, R. Gibson, J. A. Basu, P. Gebhardt, M. J. Akut, C. Robins, W. P. Mekalanos, J. Dove, S. L. Watnick, P. 2026-01-27 doi:10.64898/2026.01.27.701997 Cold Spring Harbor Laboratory Press 2026-01-27 <![CDATA[ Prenatal stress interacts with embryonic loss of Fgfr2 to increase locomotor hyperactivity in mice ]]> https://biorxiv.org/content/10.64898/2026.02.04.703738v1?rss=1 Chen, M. X. Jager, P. Sawyer, A. Stevens, H. E. 2026-02-05 doi:10.64898/2026.02.04.703738 Cold Spring Harbor Laboratory Press 2026-02-05 <![CDATA[ Adapting flow cytometry for studying immune cell seasonality in wild migratory bats ]]> https://biorxiv.org/content/10.64898/2026.02.03.702504v1?rss=1 Allira, M. Dyer, K. Demory, B. Hightower, M. Olbrys, B. Norman, K. Lang, M. Becker, D. 2026-02-06 doi:10.64898/2026.02.03.702504 Cold Spring Harbor Laboratory Press 2026-02-06 <![CDATA[ The sex determination gene fruitless is essential for male Aedes aegypti mosquito swarming and attraction to female flight sounds ]]> https://biorxiv.org/content/10.64898/2026.02.05.703956v1?rss=1 Loh, Y. M. Thornton, A. J. Lee, T.-T. Chen, W.-T. Xu, Y. Y. Eberl, D. F. Su, M. P. Kamikouchi, A. 2026-02-08 doi:10.64898/2026.02.05.703956 Cold Spring Harbor Laboratory Press 2026-02-08 <![CDATA[ Deep learning-based non-invasive profiling of tumor transcriptomes from cell-free DNA for precision oncology ]]> https://biorxiv.org/content/10.64898/2026.02.10.705188v1?rss=1 Patton, R. D. Netzley, A. Persse, T. W. Nair, A. Galipeau, P. C. Coleman, I. M. Itagi, P. Chandra, P. Adil, M. Vashisth, M. Sayar, E. Hiatt, J. B. Dumpit, R. Kollath, L. Demirci, R. A. Ghodsi, A. Lam, H.-M. Morrissey, C. Iravani, A. Chen, D. L. Hsieh, A. C. MacPherson, D. Haffner, M. C. Nelson, P. S. Ha, G. 2026-02-12 doi:10.64898/2026.02.10.705188 Cold Spring Harbor Laboratory Press 2026-02-12 <![CDATA[ Lateral Cerebellar Nucleus Lesions Disrupt Rule-Based Category Learning and Cognitive Flexibility in Rats ]]> https://biorxiv.org/content/10.64898/2026.02.11.705339v1?rss=1 Wachter, S. Broschard, M. H. Parker, K. Freeman, J. H. 2026-02-13 doi:10.64898/2026.02.11.705339 Cold Spring Harbor Laboratory Press 2026-02-13 <![CDATA[ Zfp750 prevents oral adhesions and promotes temporary epithelial fusions ]]> https://biorxiv.org/content/10.64898/2026.02.12.705205v1?rss=1 Singh, S. K. Adelizzi, E. Heffner, C. Curtis, S. Duncan, K. Awotoye, W. Olotu, J. Busch, T. Adeyemo, W. Gowans, L. J. J. Naicker, T. Murray, S. A. Butali, A. Leslie-Clarkson, E. J. Dunnwald, M. Cornell, R. A. 2026-02-14 doi:10.64898/2026.02.12.705205 Cold Spring Harbor Laboratory Press 2026-02-14 <![CDATA[ Development and characterization of mouse-adapted recombinant SARS-CoV-2 expressing reporter genes ]]> https://biorxiv.org/content/10.64898/2026.02.04.703885v1?rss=1 Mahmoud, S. H. Jackson, N. Barre, R. Ma, Y. Bayoumi, M. Castro, E. Ezzatpour, S. Plemper, R. K. Perlman, S. Ye, C. Martinez-Sobrido, L. 2026-02-16 doi:10.64898/2026.02.04.703885 Cold Spring Harbor Laboratory Press 2026-02-16 <![CDATA[ Assessing positive selection in centromere-associated kinetochore proteins across Metazoan groups. ]]> https://biorxiv.org/content/10.64898/2026.02.13.705784v1?rss=1 Healey, H. M. Gomez, L. E. Sheikh, S. I. Camel, B. R. Forbes, A. A. Sterner, K. N. Beck, E. A. 2026-02-18 doi:10.64898/2026.02.13.705784 Cold Spring Harbor Laboratory Press 2026-02-18 <![CDATA[ Hypoxic stress granules trigger immunogenic dormancy in lung cancer ]]> https://biorxiv.org/content/10.64898/2026.02.18.706626v1?rss=1 Smith, M. G. Ramos, A. R. Panchal, H. Cerkezi, N. H. Garcia, C. Spruce, L. Fazelinia, H. Maggi, L. B. Mailloux, A. W. 2026-02-20 doi:10.64898/2026.02.18.706626 Cold Spring Harbor Laboratory Press 2026-02-20 <![CDATA[ Intratumoral plasma cells are required for activation of CD8+ T cells and success of immune checkpoint blockade therapy in de novo MPNSTs ]]> https://biorxiv.org/content/10.64898/2026.02.18.706680v1?rss=1 Lingo, J. J. Reis, R. Allamargot, C. Raygoza Garay, J. A. Kaemmer, C. A. Elias, E. C. Voigt, E. Jabbari, A. Wilhelm, C. R. Boyden, A. W. Karandikar, N. J. Breheny, P. Meyerholz, D. K. Dodd, R. D. Houtman, J. C. Darbro, B. W. Quelle, D. E. 2026-02-20 doi:10.64898/2026.02.18.706680 Cold Spring Harbor Laboratory Press 2026-02-20 <![CDATA[ Defining Functional Correction Thresholds in Primary Ciliary Dyskinesia for Effective Gene Therapies ]]> https://biorxiv.org/content/10.64898/2026.02.19.706855v1?rss=1 Fitzpatrick, B. E. Wineinger, B. J. Babcock, J. E. Quiroz, E. J. Liu, E. C. Gautam, L. K. Pezzulo, A. A. Moninger, T. O. Meyerholz, D. K. Hornick, D. B. Ryan, A. L. 2026-02-20 doi:10.64898/2026.02.19.706855 Cold Spring Harbor Laboratory Press 2026-02-20 <![CDATA[ Male mice are particularly vulnerable to cognitive impairment following mTBI ]]> https://biorxiv.org/content/10.64898/2026.02.21.707169v1?rss=1 Neal, J. Bertolli, A. Aldridge, G. Emmons, E. 2026-02-23 doi:10.64898/2026.02.21.707169 Cold Spring Harbor Laboratory Press 2026-02-23 <![CDATA[ The methodological foundations of lesion network mapping remain sound ]]> https://biorxiv.org/content/10.64898/2026.02.24.707529v1?rss=1 Siddiqi, S. H. Horn, A. Schaper, F. L. Khosravani, S. Cohen, A. L. Joutsa, J. Rolston, J. D. Ferguson, M. A. Snider, S. B. Winkler, A. M. Akram, H. Smith, S. Nichols, T. E. Friston, K. Boes, A. D. Fox, M. D. 2026-02-26 doi:10.64898/2026.02.24.707529 Cold Spring Harbor Laboratory Press 2026-02-26 <![CDATA[ Ploidy reorganizes ionomic composition across metabolically active and mineralized tissues. ]]> https://biorxiv.org/content/10.64898/2026.02.26.708366v1?rss=1 Jeyasingh, P. Roseman, M. Bliss, J. Ipek, Y. Neiman, M. 2026-02-27 doi:10.64898/2026.02.26.708366 Cold Spring Harbor Laboratory Press 2026-02-27 <![CDATA[ Prior expectation shapes the emotional response to sounds: behavioural and neural correlates ]]> https://biorxiv.org/content/10.64898/2026.02.27.708425v1?rss=1 Benzaquen, E. Griffiths, T. D. Kumar, S. 2026-02-27 doi:10.64898/2026.02.27.708425 Cold Spring Harbor Laboratory Press 2026-02-27 <![CDATA[ Blood-brain barrier dysfunction predicts cognitive trajectory after ischemic stroke ]]> https://biorxiv.org/content/10.64898/2026.02.27.708013v1?rss=1 Xue, L. Jones, O. A. Drag, L. Zera, K. A. Zhu, L. Mlynash, M. Carmichael, N. S. Shu, C.-H. Biesiada, Z. Seong, D. Thomas, O. M. Simmons, E. C. Huang, E. Berry, K. Chung, P. Aslan, A. Xue, R. Rutledge, J. E. Oh, H. S.-H. Yang, L. K. James, T. Ghanem, M. Moran-Losada, P. Poston, K. L. Henderson, V. W. Grainger, J. Allan, S. M. Lansberg, M. Mormino, E. C. Wyss-Coray, T. Kapasi, A. Schneider, J. A. Smith, C. J. Parkes, L. M. Aghaeepour, N. Buckwalter, M. S. 2026-03-02 doi:10.64898/2026.02.27.708013 Cold Spring Harbor Laboratory Press 2026-03-02 <![CDATA[ Distributed neural signatures of discomfort induced by transcranial magnetic stimulation ]]> https://biorxiv.org/content/10.64898/2026.02.27.708526v1?rss=1 Li, Z. Jiao, Y. Zhang, Y. Zhang, N. Etkin, A. Boes, A. D. Oathes, D. J. Jiang, J. 2026-03-02 doi:10.64898/2026.02.27.708526 Cold Spring Harbor Laboratory Press 2026-03-02 <![CDATA[ Base-pair scale dynamics of a repair helicase on DNA lesions reveal varied damage-sensing mechanisms ]]> https://biorxiv.org/content/10.64898/2026.03.03.709311v1?rss=1 Troitskaia, A. Lasitza-Male, T. Caldwell, C. C. Spies, M. Chemla, Y. R. 2026-03-03 doi:10.64898/2026.03.03.709311 Cold Spring Harbor Laboratory Press 2026-03-03 <![CDATA[ Molecular Transducers of Physical Activity Consortium (MoTrPAC): Initial Insights into the Dynamic Human Responses to Exercise ]]> https://biorxiv.org/content/10.64898/2026.03.02.705347v1?rss=1 View larger version (65K): org.highwire.dtl.DTLVardef@554ee9org.highwire.dtl.DTLVardef@afb28dorg.highwire.dtl.DTLVardef@f381cdorg.highwire.dtl.DTLVardef@cef19c_HPS_FORMAT_FIGEXP M_FIG C_FIG ]]> MoTrPAC Study Group, Brandt, A. R. Fleg, J. Goodpaster, B. H. Jaeger, B. Jin, C. A. Johannsen, N. M. Katz, D. Keshishian, H. Kohrt, W. M. Kraus, W. E. Lester, B. Melanson, E. L. Miller, M. E. Montalvo, S. Rejeski, W. J. Shimly, S. M. Smith, G. R. Stowe, C. L. Trappe, S. AbouAssi, H. Adams, N. Amar, D. Ashley, E. Aslamy, A. Bamman, M. M. Belangee, A. Bennett, W. Bergman, B. C. Bessesen, D. H. Bodine, S. C. Boyd, G. Buford, T. W. Burant, C. F. Carnero, E. A. Carr, S. Chambers, T. L. Chavez, C. Chen, H. Chen, S.-H. Christle, J. W. Claiborne, A. Clark, N 2026-03-05 doi:10.64898/2026.03.02.705347 Cold Spring Harbor Laboratory Press 2026-03-05 <![CDATA[ Learned and inferred valence arise from interactions between stable and dynamic subnetworks ]]> https://biorxiv.org/content/10.64898/2026.03.08.710406v1?rss=1 Normandin, M. E. Ogallar, P. M. Lopez, M. R. Muzzio, I. A. 2026-03-10 doi:10.64898/2026.03.08.710406 Cold Spring Harbor Laboratory Press 2026-03-10 <![CDATA[ Robust volumetric multiplex staining of centimeter-scale FFPE tissues guided by neural network-based optimization ]]> https://biorxiv.org/content/10.64898/2026.03.09.710440v1?rss=1 Lin, Y.-H. Huang, C.-Y. Chen, Y.-H. Chen, Y.-H. Xu, Z.-W. Ko, P.-L. Hsu, H.-H. Tung, Y.-C. Chen, Y.-F. Chen, H.-C. Chiang, A.-S. Fiock, K. L. Wang, K.-C. Lin, C.-H. Hu, S.-H. Chen, B.-C. Chu, L.-A. 2026-03-11 doi:10.64898/2026.03.09.710440 Cold Spring Harbor Laboratory Press 2026-03-11 <![CDATA[ The prevalence of protein misfolding as a mechanism for hereditary deafness ]]> https://biorxiv.org/content/10.64898/2026.03.09.710547v1?rss=1 Gogal, R. A. Cox, G. M. Kolbe, D. L. Odell, A. M. Ovel, C. E. McCormick, K. I. Hong, B. Azaiez, H. Casavant, T. L. Smith, R. J. H. Braun, T. A. Schnieders, M. J. 2026-03-11 doi:10.64898/2026.03.09.710547 Cold Spring Harbor Laboratory Press 2026-03-11 <![CDATA[ Immune response to spiral ganglion neuron death in rats during development and after kanamycin-induced deafening ]]> https://biorxiv.org/content/10.64898/2026.03.10.710901v1?rss=1 Caro, A. M. Zhang, Z. Gansemer, B. M. Green, S. H. 2026-03-13 doi:10.64898/2026.03.10.710901 Cold Spring Harbor Laboratory Press 2026-03-13 <![CDATA[ Behavioral, Physiological, and Transcriptional Mechanisms of Memory in a Synthetic Living Construct ]]> https://biorxiv.org/content/10.64898/2026.03.17.712168v1?rss=1 Pai, V. P. Traer, J. A. Sperry, M. M. Zeng, Y. Levin, M. 2026-03-17 doi:10.64898/2026.03.17.712168 Cold Spring Harbor Laboratory Press 2026-03-17 <![CDATA[ Transcranial magnetic stimulation to the dorsolateral prefrontal cortex modulates single-neuron activity in humans ]]> https://biorxiv.org/content/10.64898/2026.03.15.711839v1?rss=1 Dickey, C. W. Hassan, U. Kawasaki, H. Rhone, A. E. Cline, C. C. Howard, M. A. Trapp, N. T. Boes, A. D. Berger, J. I. Keller, C. J. 2026-03-18 doi:10.64898/2026.03.15.711839 Cold Spring Harbor Laboratory Press 2026-03-18 <![CDATA[ Pharmacological METTL3 inhibition attenuates HIV-1 latency reversal in CD4+ T cells ]]> https://biorxiv.org/content/10.64898/2026.03.18.712554v1?rss=1 Mishra, T. Edwards, A. Wu, L. 2026-03-20 doi:10.64898/2026.03.18.712554 Cold Spring Harbor Laboratory Press 2026-03-20 <![CDATA[ Metabolic Analysis of Human Retinal Pigment Epithelium and Choroid Tissue in Aging and Macular Degeneration ]]> https://biorxiv.org/content/10.64898/2026.03.24.713982v1?rss=1 Navratil, E. M. Liu, X. Wiley, L. A. Anderson, M. G. Meyer, K. J. Brown, R. F. Evans, I. A. Taylor, E. B. Stone, E. M. Tucker, B. A. Mullins, R. F. 2026-03-26 doi:10.64898/2026.03.24.713982 Cold Spring Harbor Laboratory Press 2026-03-26 <![CDATA[ ATF4 Coordinates Transcriptomic and Structural Adaptations in Aging Muscle ]]> https://biorxiv.org/content/10.64898/2026.03.27.711928v1?rss=1 Crabtree, A. Khan, M. M. Scudese, E. Hernandez Perez, C. P. Venkhatesh, P. Marshall, A. G. Rodriguez, B. Garza Lopez, E. Ochayi, O. M. Dantas, E. H. M. Martin, P. Baffi, M. Scartoni, F. Mungai, M. Neikirk, K. Streeter, J. Pereira, R. O. Dai, D. F. Le, H. Mobley, H. Afolabi, J. Mobley, B. C. Wanjalla, C. N. Hall, D. Berry, J. Kovtun, O. Schafer, J. C. Schaffer, S. Katti, P. Evans, C. Kinder, A. George, J. G. McReynolds, M. Kirabo, A. Masenga, S. K. Hinton, A. 2026-03-30 doi:10.64898/2026.03.27.711928 Cold Spring Harbor Laboratory Press 2026-03-30 <![CDATA[ Single-Cell Gene Expression and eQTL Analyses in the Human Retina, RPE, and Choroid in Macular Degeneration ]]> https://biorxiv.org/content/10.64898/2026.03.30.714946v1?rss=1 Voigt, A. P. Mullin, N. K. Mulfaul, K. Lozano, L. P. Navratil, E. M. Flamme-Wiese, M. J. Lavine, J. A. Fingert, J. H. Tucker, B. A. Stone, E. M. Scheetz, T. E. Mullins, R. F. 2026-04-01 doi:10.64898/2026.03.30.714946 Cold Spring Harbor Laboratory Press 2026-04-01 <![CDATA[ Myelin-Free Nuclei Isolation from Mouse Hippocampus and Cerebellum for snRNA-Seq with Benchtop Gradient Centrifugation ]]> https://biorxiv.org/content/10.64898/2026.04.03.716374v1?rss=1 View larger version (35K): org.highwire.dtl.DTLVardef@ccbd87org.highwire.dtl.DTLVardef@1aef4bcorg.highwire.dtl.DTLVardef@14569a8org.highwire.dtl.DTLVardef@1bc261_HPS_FORMAT_FIGEXP M_FIG C_FIG HighlightsO_LIBenchtop sucrose-gradient pelleting enables rapid nuclei purification from myelin-rich adult mouse brain C_LIO_LIScales across tissue inputs (e.g., hippocampus [~]15-20 mg; cerebellum [~]50-70 mg) without ultracentrifugation or 15 mL gradients C_LIO_LIMagnetic enrichment as the recommended final cleanup step further reduces myelin/debris carryover and is compatible with 10x Flex and PARSE WT workflows. C_LI ]]> George, B. Kirkpatrick, B. Q. 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