It would be nice to see whether the reduction of WNT5A+/IL24+ fibroblasts also occurred for class V-VII corticosteroids given that the the higher potency corticosteroids are advised for short-term use. I wonder if a reduction in the WNT5A+/IL24+ fibroblast cells would occur as quickly or with the same magnitude when using less potent/strong corticosteroid medications. I’d also be interested to see if Vtama (tapinarof) leads to a WNT5A+/IL24+ fibroblast reduction as well.

This is an interesting finding! I imagine that it could be helpful to use this as a potential in screen for new psoriasis treatments if human diseased skin is accessible (with the caveat that this finding was based on samples from males of European descent).

Missing parenthesis: “ACKR1+/FABP4+ capillaries (FDR<10-7 in both).”