bioRxiv Subject Collection: Pathology
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This feed contains articles for bioRxiv Subject Collection "Pathology"
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Explainable machine learning relates histological to genomic pathology
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https://www.biorxiv.org/content/10.64898/2026.08.03.742582v1?rss=1
2026-08-09doi:10.64898/2026.08.03.742582Cold Spring Harbor Laboratory2026-08-09
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Hepatocyte Angiotensinogen Deletion Protects Against Diet-induced Metabolic Disorders in Mice Under Thermoneutral Conditions
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https://www.biorxiv.org/content/10.64898/2026.08.04.742617v1?rss=1
2026-08-09doi:10.64898/2026.08.04.742617Cold Spring Harbor Laboratory2026-08-09
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Biomineralization from platelet δ-granules as the origin of cardiovascular calcification in humans and other animals.
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https://www.biorxiv.org/content/10.64898/2026.08.01.742085v1?rss=1
2026-08-06doi:10.64898/2026.08.01.742085Cold Spring Harbor Laboratory2026-08-06
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An industry perspective on whole genome-informed hybrid maize disease resistance characterization to improve breeding decisions
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https://www.biorxiv.org/content/10.64898/2026.07.30.741863v1?rss=1
2026-08-05doi:10.64898/2026.07.30.741863Cold Spring Harbor Laboratory2026-08-05
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Neutrophils-Nitroblue Tetrazolium staining: A potential novel marker of women infertilely?
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https://www.biorxiv.org/content/10.64898/2026.08.02.742324v1?rss=1
2026-08-04doi:10.64898/2026.08.02.742324Cold Spring Harbor Laboratory2026-08-04
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CD133+ progenitor cells promote pulmonary hypertension through CXCR4 signaling
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https://www.biorxiv.org/content/10.64898/2026.07.29.741640v1?rss=1
2026-08-02doi:10.64898/2026.07.29.741640Cold Spring Harbor Laboratory2026-08-02
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Automated Virtual Pathology Panels for Mass Spectrometry Imaging
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https://www.biorxiv.org/content/10.64898/2026.07.26.740867v1?rss=1
2026-07-29doi:10.64898/2026.07.26.740867Cold Spring Harbor Laboratory2026-07-29
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Droplet microfluidics reports digital and tuneable single-platelet ADP secretion describing primed, active and hyper-active states
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https://www.biorxiv.org/content/10.64898/2026.07.24.740520v1?rss=1
2026-07-28doi:10.64898/2026.07.24.740520Cold Spring Harbor Laboratory2026-07-28
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Cortical organoids from congenital DM1 PSCs reveal MBNL-dependent corticogenesis defects and enable preclinical testing of therapeutic compounds
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https://www.biorxiv.org/content/10.64898/2026.07.23.740263v1?rss=1
1000 CTG repeats, an expansion typically associated with CDM, to model early human neurodevelopment. DM1 molecular and cellular hallmarks were detected at early developmental stages, including nuclear DMPK RNA foci in neural progenitor cells and reduced proliferative capacity. As organoids matured, CDM cultures displayed altered cortical composition, with reduced CTIP2 and SATB2 neuronal populations and increased NFIA/GFAP glial cells. In parallel, 120-day-old organoids recapitulated splicing abnormalities previously identified in DM1 patient brain tissue. To assess the contribution of MBNL dysfunction, we analyzed cortical organoids derived from MBNL2 and MBNL1/2/3 knockout induced pluripotent stem cells, which reproduced key neurodevelopmental phenotypes observed in CDM organoids, supporting a central role for MBNL loss of function in impaired corticogenesis. Finally, we evaluated the translational relevance of this model using tideglusib and erythromycin, two compounds currently under clinical evaluation in DM1 patients. Both treatments reduced DMPK RNA foci and restored proliferation defects in SOX2 neural progenitors. Together, these findings establish cortical organoids as a robust human model of CDM-associated neurodevelopmental defects, uncover MBNL-dependent mechanisms underlying early corticogenesis impairment and demonstrate the utility of this platform for translational therapeutic discovery in DM1.
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Sensory Neuropeptides Dictate Sex-Specific Synovial Immunity and Cartilage Degeneration in Aging Mice
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https://www.biorxiv.org/content/10.64898/2026.07.27.740931v1?rss=1
2026-07-27doi:10.64898/2026.07.27.740931Cold Spring Harbor Laboratory2026-07-27
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First Order Associations Between Banff Acute Lesions in Kidney Allograft Biopsies and a Urinary Cell Three-Gene Diagnostic Signature
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https://www.biorxiv.org/content/10.64898/2026.07.22.740171v1?rss=1
2026-07-27doi:10.64898/2026.07.22.740171Cold Spring Harbor Laboratory2026-07-27
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Bioenergetic profiling of fresh human kidney tissue reveals compensatory metabolic adaptation and intrinsic mitochondrial dysfunction in diabetes
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https://www.biorxiv.org/content/10.64898/2026.07.23.740003v1?rss=1
View larger version (35K):
org.highwire.dtl.DTLVardef@e892e6org.highwire.dtl.DTLVardef@1043c8eorg.highwire.dtl.DTLVardef@123affaorg.highwire.dtl.DTLVardef@1f68645_HPS_FORMAT_FIGEXP M_FIG C_FIG One Sentence SummaryDiabetes drives early metabolic reprogramming of the human kidney before measurable kidney dysfunction
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FRESH FROZEN PLASMA-BASED RESUSCITATION LESSENS LUNG INJURY IN MICE WITH ABDOMINAL SEPSIS AND HEMORRHAGIC SHOCK
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https://www.biorxiv.org/content/10.64898/2026.07.22.739847v1?rss=1
2026-07-26doi:10.64898/2026.07.22.739847Cold Spring Harbor Laboratory2026-07-26
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Stress limits the beneficial effects of glutamine in male ob/ob mice
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https://www.biorxiv.org/content/10.64898/2026.07.21.739777v1?rss=1
2026-07-24doi:10.64898/2026.07.21.739777Cold Spring Harbor Laboratory2026-07-24
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Ultrastructural remodelling of tau fibrils during ghost tangle formation in Alzheimer's disease brain
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https://www.biorxiv.org/content/10.64898/2026.07.21.739778v1?rss=1
2026-07-24doi:10.64898/2026.07.21.739778Cold Spring Harbor Laboratory2026-07-24
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Hyaluronan and CD44 targeting reverses early matrix changes, proinflammatory signals and fibrosis in primary sclerosing cholangitis
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https://www.biorxiv.org/content/10.64898/2026.07.21.739845v1?rss=1
2026-07-24doi:10.64898/2026.07.21.739845Cold Spring Harbor Laboratory2026-07-24
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Imaging-Based Age- and Sex-specific Cardiovascular and Skeletal Phenotypes in Fbn1C1041G/+ Mice
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https://www.biorxiv.org/content/10.64898/2026.07.21.739835v1?rss=1
2026-07-24doi:10.64898/2026.07.21.739835Cold Spring Harbor Laboratory2026-07-24
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Pan-Peroxisome Proliferator-Activated Receptor Agonist IVA337 Alleviates Secondary Lymphedema via Inhibiting TGFβ/SMAD2/3 Signaling Pathway
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https://www.biorxiv.org/content/10.64898/2026.07.20.739660v1?rss=1
2026-07-24doi:10.64898/2026.07.20.739660Cold Spring Harbor Laboratory2026-07-24
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Lack of canonical PAR4 activation is associated with reduced arterial and venous thrombosis in mice.
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https://www.biorxiv.org/content/10.64898/2026.07.20.739624v1?rss=1
2026-07-23doi:10.64898/2026.07.20.739624Cold Spring Harbor Laboratory2026-07-23
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Super-resolution imaging with deep learning-based segmentation for detailed characterization of mitochondrial arrangement in Pompe disease skeletal muscle
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https://www.biorxiv.org/content/10.64898/2026.07.21.739567v1?rss=1
2026-07-22doi:10.64898/2026.07.21.739567Cold Spring Harbor Laboratory2026-07-22
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Multi-model Segmentation and Morphometric Quantification of Cerebral Amyloid Angiopathy in Alzheimer's Disease Whole Slide Histopathology Images
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https://www.biorxiv.org/content/10.64898/2026.07.16.739032v1?rss=1
2026-07-21doi:10.64898/2026.07.16.739032Cold Spring Harbor Laboratory2026-07-21
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Microvascular pathology of proteotoxic endothelial signature characterizes Progressive Supranuclear Palsy
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https://www.biorxiv.org/content/10.64898/2026.07.16.738175v1?rss=1
2026-07-21doi:10.64898/2026.07.16.738175Cold Spring Harbor Laboratory2026-07-21
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Extracellular Matrix Proteomic Signatures Associate with Disease-Free Survival in Later Events of Ductal Carcinoma In Situ or Invasive Breast Cancer
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https://www.biorxiv.org/content/10.64898/2026.07.16.738889v1?rss=1
0.98, accuracy >93%) in distinguishing primary from later events. Following prior work in the RAHBT cohort, reduction of certain collagen peptides was also observed in primary DCIS samples from higher risk patient groups.
ConclusionsECM proteomic remodeling, particularly decreases of specific collagen domains, is strongly associated with later events of DCIS and IBC. These findings highlight ECM proteome as a critical regulator of breast cancer emergence with potential as a prognosticator of risk stratification to guide clinical management of DCIS.
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Multicenter self-supervised computational pathology identifies prognostic histomorphological phenotypes in colorectal cancer
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https://www.biorxiv.org/content/10.64898/2026.07.15.738753v1?rss=1
2026-07-21doi:10.64898/2026.07.15.738753Cold Spring Harbor Laboratory2026-07-21
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Advancing Plant Health in Sub-Saharan Africa: Understanding National Agricultural Research Institutions capacities for Strategic Investment Priorities to Boost Genetic Gains Against Crop Biotic Stress
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https://www.biorxiv.org/content/10.64898/2026.07.19.739424v1?rss=1
2026-07-20doi:10.64898/2026.07.19.739424Cold Spring Harbor Laboratory2026-07-20
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Quantifying Cross-Modal Shared Information Between Histomorphology and Spatial Transcriptomics via Spatiotemporal Trajectory Correlation
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https://www.biorxiv.org/content/10.64898/2026.07.13.738201v1?rss=1
2026-07-19doi:10.64898/2026.07.13.738201Cold Spring Harbor Laboratory2026-07-19
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SERPINB13 is a prognostic biomarker for LUSC associated with an immune-inflamed tumor phenotype and modulated by immune cells
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https://www.biorxiv.org/content/10.64898/2026.07.11.737907v1?rss=1
2026-07-16doi:10.64898/2026.07.11.737907Cold Spring Harbor Laboratory2026-07-16
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Prototype-based AI triage for 3D pathology
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https://www.biorxiv.org/content/10.64898/2026.07.09.737559v1?rss=1
2026-07-15doi:10.64898/2026.07.09.737559Cold Spring Harbor Laboratory2026-07-15
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Spatial Glyco-Codes Define Human Liver Pathology and Progression
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https://www.biorxiv.org/content/10.64898/2026.07.08.737217v1?rss=1
2026-07-12doi:10.64898/2026.07.08.737217Cold Spring Harbor Laboratory2026-07-12
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First report on Chicken Pediculosis in Modern Battery-Cage Layer Farms in Bangladesh: Behavioral, Pathological and Production Performance Impacts
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https://www.biorxiv.org/content/10.64898/2026.07.07.737031v1?rss=1
2026-07-11doi:10.64898/2026.07.07.737031Cold Spring Harbor Laboratory2026-07-11