bioRxiv Subject Collection: Genomics Bioinformatics Genetics Molecular Biology Developmental Biology
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This feed contains articles for bioRxiv Subject Collection "Genomics Bioinformatics Genetics Molecular Biology Developmental Biology"
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Early life stress affects the transcription and chromatin accessibility of spermatogonial cells
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https://www.biorxiv.org/content/10.64898/2026.08.20.745941v1?rss=1
2026-08-25doi:10.64898/2026.08.20.745941Cold Spring Harbor Laboratory2026-08-25
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An Epigenetic Signature of Vulnerable Neurons is Under Selective Pressure Associated with Longevity Across Placental Mammals.
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https://www.biorxiv.org/content/10.64898/2026.08.20.745782v1?rss=1
2026-08-25doi:10.64898/2026.08.20.745782Cold Spring Harbor Laboratory2026-08-25
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optix regulates abdominal melanin pigmentation in the tobacco hawkmoth Manduca sexta
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https://www.biorxiv.org/content/10.64898/2026.08.20.746068v1?rss=1
2026-08-25doi:10.64898/2026.08.20.746068Cold Spring Harbor Laboratory2026-08-25
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MPGEM: A harmonized and transcriptome-complete resource for large-scale reuse of legacy human microarray data
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https://www.biorxiv.org/content/10.64898/2026.08.20.746052v1?rss=1
2026-08-25doi:10.64898/2026.08.20.746052Cold Spring Harbor Laboratory2026-08-25
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Expression of AAACTAC satellite repeats as a long noncoding RNA in the early oocyte of Drosophila virilis
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https://www.biorxiv.org/content/10.64898/2026.08.24.746749v1?rss=1
2026-08-25doi:10.64898/2026.08.24.746749Cold Spring Harbor Laboratory2026-08-25
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Lifecourse sex-specific molecular response to early-life exposures of toxic substances
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https://www.biorxiv.org/content/10.64898/2026.08.20.746014v1?rss=1
2026-08-25doi:10.64898/2026.08.20.746014Cold Spring Harbor Laboratory2026-08-25
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Single-cell roadmap of bovine oogenesis and somatic niche interactions during fetal ovarian development
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https://www.biorxiv.org/content/10.64898/2026.08.24.745837v1?rss=1
2026-08-25doi:10.64898/2026.08.24.745837Cold Spring Harbor Laboratory2026-08-25
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Cholesterol transport cycle of human ABCA2
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https://www.biorxiv.org/content/10.64898/2026.08.25.746927v1?rss=1
2026-08-25doi:10.64898/2026.08.25.746927Cold Spring Harbor Laboratory2026-08-25
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Vangl2 acts in distinct cell types to establish bidirectional hair-bundle polarity and maintains tissue-wide alignment in zebrafish neuromasts
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https://www.biorxiv.org/content/10.64898/2026.08.24.746764v1?rss=1
2026-08-25doi:10.64898/2026.08.24.746764Cold Spring Harbor Laboratory2026-08-25
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Acute activation of autophagy enables growth plate regeneration following radiation-induced injury.
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https://www.biorxiv.org/content/10.64898/2026.08.24.746001v1?rss=1
2026-08-25doi:10.64898/2026.08.24.746001Cold Spring Harbor Laboratory2026-08-25
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Irregular nucleosome positioning governs a crystalline to liquid-like phase transition and tunes chromatin accessibility
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https://www.biorxiv.org/content/10.64898/2026.08.24.746683v1?rss=1
2026-08-25doi:10.64898/2026.08.24.746683Cold Spring Harbor Laboratory2026-08-25
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Position-Dependent NMD Generates Diverse Protein Outcomes
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https://www.biorxiv.org/content/10.64898/2026.08.24.746594v1?rss=1
2026-08-25doi:10.64898/2026.08.24.746594Cold Spring Harbor Laboratory2026-08-25
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CpG islands act as topological sinks for transcription-induced DNA supercoiling
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https://www.biorxiv.org/content/10.64898/2026.08.24.746546v1?rss=1
2026-08-25doi:10.64898/2026.08.24.746546Cold Spring Harbor Laboratory2026-08-25
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DePARylation prevents DNA replication-driven PARP1 condensation
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https://www.biorxiv.org/content/10.64898/2026.08.24.746650v1?rss=1
2026-08-25doi:10.64898/2026.08.24.746650Cold Spring Harbor Laboratory2026-08-25
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Genetic and Behavioral Variation Underlying an Integrated Temporal Phenotype in an Admixed South American Population
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https://www.biorxiv.org/content/10.64898/2026.08.18.745563v1?rss=1
2026-08-24doi:10.64898/2026.08.18.745563Cold Spring Harbor Laboratory2026-08-24
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Fendioxypyracil Exhibits Potent Inhibition of PPO-Resistant Mutant Enzymes and Robust Activity Against PPO-Resistant Amaranthus
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https://www.biorxiv.org/content/10.64898/2026.08.23.746358v1?rss=1
2026-08-24doi:10.64898/2026.08.23.746358Cold Spring Harbor Laboratory2026-08-24
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Predicting Protein-RNA Binding Affinity Changes via Spatial Coupling-Aware State Space Modeling
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https://www.biorxiv.org/content/10.64898/2026.08.23.745486v1?rss=1
2026-08-24doi:10.64898/2026.08.23.745486Cold Spring Harbor Laboratory2026-08-24
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A chromosome-level assembly of an aquatic passerine bird, the northern white-throated dipper, Cinclus cinclus cinclus (Linnaeus, 1758)
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https://www.biorxiv.org/content/10.64898/2026.08.20.746034v1?rss=1
2026-08-24doi:10.64898/2026.08.20.746034Cold Spring Harbor Laboratory2026-08-24
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Genome sequencing reveals novel pathogenic deep-intronic PCDH15 variants, amenable to antisense oligonucleotide-based splice correction
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https://www.biorxiv.org/content/10.64898/2026.08.20.746067v1?rss=1
G and c.3123-1728A>G, in two independent patients. Both deep-intronic variants were classified as likely pathogenic and predicted to alter PCDH15 pre-mRNA splicing. Using a minigene splice assay and iPSC-derived photoreceptor precursor cells from patients, we confirmed that both variants lead to the inclusion of a pseudoexon in the PCDH15 transcript introducing a stop codon and subsequent premature termination of protein translation. We designed and evaluated antisense oligonucleotides (ASOs) with the purpose of redirecting aberrant pre-mRNA splicing caused by both deep-intronic variants. For both variants, designed ASOs were successful in restoring normal splicing patterns, highlighting their potential as a future therapeutic intervention strategy to halt the progression of retinitis pigmentosa caused by these novel variants. Overall, these findings contribute to the understanding of Usher syndrome caused by deep-intronic pathogenic variants in PCDH15 and describe for the first time the use of an ASO-mediated splice correction strategy for individuals diagnosed with these variants.
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Microenvironment-informed inference of transcriptional progression geometry
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https://www.biorxiv.org/content/10.64898/2026.08.21.746284v1?rss=1
2026-08-24doi:10.64898/2026.08.21.746284Cold Spring Harbor Laboratory2026-08-24
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CodonMamba: a foundation model for programmable mRNA coding sequence design
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https://www.biorxiv.org/content/10.64898/2026.08.24.746601v1?rss=1
2026-08-24doi:10.64898/2026.08.24.746601Cold Spring Harbor Laboratory2026-08-24
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RADF: Reference-Anchored Dynamic Flow for Spatial Perturbation Profile Completion
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https://www.biorxiv.org/content/10.64898/2026.08.20.745474v1?rss=1
2026-08-24doi:10.64898/2026.08.20.745474Cold Spring Harbor Laboratory2026-08-24
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Trust-Aware Sequence-to-Function Modelling in Regulatory Genomics
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https://www.biorxiv.org/content/10.64898/2026.08.20.745945v1?rss=1
2026-08-24doi:10.64898/2026.08.20.745945Cold Spring Harbor Laboratory2026-08-24
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Next-generation insect digitization: combining phenomics and genomics by subsequent synchrotron X-ray imaging and DNA sequencing
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https://www.biorxiv.org/content/10.64898/2026.08.20.745929v1?rss=1
2026-08-24doi:10.64898/2026.08.20.745929Cold Spring Harbor Laboratory2026-08-24
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Kiosc: an integrated platform for managing bioinformatics data analysis containers
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https://www.biorxiv.org/content/10.64898/2026.08.20.745983v1?rss=1
2026-08-24doi:10.64898/2026.08.20.745983Cold Spring Harbor Laboratory2026-08-24
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Benchmarking antibody-antigen co-folding on human monomeric antigens
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https://www.biorxiv.org/content/10.64898/2026.08.20.745880v1?rss=1
2026-08-24doi:10.64898/2026.08.20.745880Cold Spring Harbor Laboratory2026-08-24
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Haplotype-resolved chromosome-level genome assembly of four European white oak species
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https://www.biorxiv.org/content/10.64898/2026.08.20.745905v1?rss=1
2026-08-24doi:10.64898/2026.08.20.745905Cold Spring Harbor Laboratory2026-08-24
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Four-species Aspergillus pan-GWAS reveals rare genome expansion in pathogenicity and contraction in domestication
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https://www.biorxiv.org/content/10.64898/2026.08.20.745736v1?rss=1
2026-08-24doi:10.64898/2026.08.20.745736Cold Spring Harbor Laboratory2026-08-24
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u4atac regulates cilium biogenesis through splicing of the minor intron of tmem107l and rfx7b in zebrafish developing brain
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https://www.biorxiv.org/content/10.64898/2026.08.20.745718v1?rss=1
2026-08-24doi:10.64898/2026.08.20.745718Cold Spring Harbor Laboratory2026-08-24
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Model Validation Protocols for Machine Learning in Small Molecule Drug Discovery
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https://www.biorxiv.org/content/10.64898/2026.08.19.745868v1?rss=1
2026-08-24doi:10.64898/2026.08.19.745868Cold Spring Harbor Laboratory2026-08-24