bioRxiv Subject Collection: Genomics
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This feed contains articles for bioRxiv Subject Collection "Genomics"
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PC1-guided transcriptomic stratification reveals hepatic transcriptional heterogeneity and defines a myeloid-associated 20-gene signature
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https://www.biorxiv.org/content/10.64898/2026.08.14.744782v1?rss=1
2026-08-18doi:10.64898/2026.08.14.744782Cold Spring Harbor Laboratory2026-08-18
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Population genomics of the inquiline social parasite Acromyrmex insinuator and its leaf-cutting ant hosts A. echinatior and A. octospinosus reveals cryptic differentiation and reduced efficiency of selection in the parasite
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https://www.biorxiv.org/content/10.64898/2026.08.14.744094v1?rss=1
2026-08-18doi:10.64898/2026.08.14.744094Cold Spring Harbor Laboratory2026-08-18
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Genomic variation associated with endosymbiont shuffling and areal growth in the endangered elkhorn coral, Acropora palmata
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https://www.biorxiv.org/content/10.64898/2026.08.14.744775v1?rss=1
2026-08-18doi:10.64898/2026.08.14.744775Cold Spring Harbor Laboratory2026-08-18
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Complete mitochondrial genomes of Arizona West Nile virus vectors, Culex quinquefasciatus and Culex tarsalis
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https://www.biorxiv.org/content/10.64898/2026.08.14.744795v1?rss=1
2026-08-18doi:10.64898/2026.08.14.744795Cold Spring Harbor Laboratory2026-08-18
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Single-cell profiling identifies STAT3/NF-κB regulatory hubs and cytokine crosstalk in the tumor microenvironment
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https://www.biorxiv.org/content/10.64898/2026.08.14.744802v1?rss=1
2026-08-18doi:10.64898/2026.08.14.744802Cold Spring Harbor Laboratory2026-08-18
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ADVANCING GENOTYPE IMPUTATION IN ANCIENT GENOMES USING A REGION-SPECIFIC REFERENCE PANEL AND BENCHMARK GENOTYPES
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https://www.biorxiv.org/content/10.64898/2026.08.13.744432v1?rss=1
2026-08-18doi:10.64898/2026.08.13.744432Cold Spring Harbor Laboratory2026-08-18
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Pretraining Enhances Megabase-Scale Gene Expression Prediction with GeneUnet
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https://www.biorxiv.org/content/10.64898/2026.08.13.744387v1?rss=1
2026-08-18doi:10.64898/2026.08.13.744387Cold Spring Harbor Laboratory2026-08-18
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Chromosomal instability shapes spatial and temporal phenotypic diversity in a malignant peripheral nerve sheath tumour
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https://www.biorxiv.org/content/10.64898/2026.08.13.744699v1?rss=1
2026-08-18doi:10.64898/2026.08.13.744699Cold Spring Harbor Laboratory2026-08-18
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Transcriptional and isoform-level regulation of lipid-candidate genes in preeclamptic placentas
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https://www.biorxiv.org/content/10.64898/2026.08.17.745256v1?rss=1
2026-08-18doi:10.64898/2026.08.17.745256Cold Spring Harbor Laboratory2026-08-18
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A Conserved Regenerative Architecture Underlies Skeletal Muscle Repair in Adult Zebrafish
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https://www.biorxiv.org/content/10.64898/2026.08.12.744335v1?rss=1
2026-08-18doi:10.64898/2026.08.12.744335Cold Spring Harbor Laboratory2026-08-18
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Nanopore sequencing measures chromosome end-specific telomere lengths in human cells
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https://www.biorxiv.org/content/10.64898/2026.08.15.745035v1?rss=1
2026-08-18doi:10.64898/2026.08.15.745035Cold Spring Harbor Laboratory2026-08-18
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Valeriana officinalis genome sequence reveals candidate genes for valerenic acid biosynthesis and flavonoid metabolism
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https://www.biorxiv.org/content/10.64898/2026.08.14.744958v1?rss=1
2026-08-18doi:10.64898/2026.08.14.744958Cold Spring Harbor Laboratory2026-08-18
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Guide RNA binding induces reverse transcription bias during RT-qPCR analysis of RNA-targeting CRISPR/Cas systems
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https://www.biorxiv.org/content/10.64898/2026.08.16.745121v1?rss=1
2026-08-17doi:10.64898/2026.08.16.745121Cold Spring Harbor Laboratory2026-08-17
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Benchmarking fragmentation-derived artificial cfDNA reference standards
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https://www.biorxiv.org/content/10.64898/2026.08.12.744389v1?rss=1
2026-08-17doi:10.64898/2026.08.12.744389Cold Spring Harbor Laboratory2026-08-17
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Decoding single-cell replication states from imaging data reveals locus-specific subnuclear position dependencies of replication initiation
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https://www.biorxiv.org/content/10.64898/2026.08.12.744402v1?rss=1
2026-08-17doi:10.64898/2026.08.12.744402Cold Spring Harbor Laboratory2026-08-17
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Spatial microRNA profiling at single-cell resolution by in situ barcoded extension
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https://www.biorxiv.org/content/10.64898/2026.08.12.744364v1?rss=1
2026-08-17doi:10.64898/2026.08.12.744364Cold Spring Harbor Laboratory2026-08-17
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Metabolic disease-relevant stimuli unmask context-dependent genetic regulation of cardiometabolic loci in human adipocytes
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https://www.biorxiv.org/content/10.64898/2026.08.12.744187v1?rss=1
2026-08-17doi:10.64898/2026.08.12.744187Cold Spring Harbor Laboratory2026-08-17
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The prenatal exposome and genome in predictive modelling of DNA methylation
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https://www.biorxiv.org/content/10.64898/2026.08.12.742972v1?rss=1
2026-08-17doi:10.64898/2026.08.12.742972Cold Spring Harbor Laboratory2026-08-17
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mV2G: a multiomic atlas for tissue-specific variant-to-gene prioritization
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https://www.biorxiv.org/content/10.64898/2026.08.11.743997v1?rss=1
90% of variants reside in noncoding regions. Existing V2G resources provide complementary regulatory evidence but are fragmented and often lack tissue-specific interpretation. To address this challenge, we constructed the mV2G atlas by integrating 24 types of functional genomic evidence across 50 human tissues, including molecular quantitative trait loci, enhancer-gene predictions, three-dimensional chromatin interactions, and experimental validation. The atlas contains 188,634,118 evidence-supported V2G pairs involving 13,618,039 variants and 69,521 genes. We further developed a unified tissue-specific V2G prioritization framework and prioritized 1,530,420 high-confidence functional V2G pairs involving 1,131,316 unique variants, with 87% exhibiting tissue-specificity. The mV2G atlas provides searchable variant- and gene-centered interfaces, an interactive browser for visualizing variants, target genes, cis-regulatory elements, and chromatin states, as well as downloadable datasets. By integrating complementary regulatory evidence into a unified framework, mV2G provides an accessible resource for interpreting the functional and phenotypic impact of genomic variation in relevant tissues for human diseases.
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Neuronal Gene Architecture in Cancer borealis Revealed by Long-Read Genome Assembly and Deep Transcriptomic Analysis
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https://www.biorxiv.org/content/10.64898/2026.08.12.744261v1?rss=1
2026-08-17doi:10.64898/2026.08.12.744261Cold Spring Harbor Laboratory2026-08-17
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An iteratively curated CRISPR library reveals target-specific biological resistance landscapes across targeted protein degraders
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https://www.biorxiv.org/content/10.64898/2026.08.14.744749v1?rss=1
2026-08-16doi:10.64898/2026.08.14.744749Cold Spring Harbor Laboratory2026-08-16
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Chromosome-level reference genome assembly of the Saimaa ringed seal (Pusa saimensis) - an ancient glacial relict landlocked pinniped
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https://www.biorxiv.org/content/10.64898/2026.08.13.744633v1?rss=1
2026-08-16doi:10.64898/2026.08.13.744633Cold Spring Harbor Laboratory2026-08-16
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A CRISPR-Cas9 platform for primary human hepatocytes enables arrayed screening and in vivo validation of HBV host factors
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https://www.biorxiv.org/content/10.64898/2026.08.10.743996v1?rss=1
2026-08-15doi:10.64898/2026.08.10.743996Cold Spring Harbor Laboratory2026-08-15
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Whole-genome resequencing-based comparative variant analysis identifies candidate genes associated with cross-beak phenotype in Huiyang Bearded chickens
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https://www.biorxiv.org/content/10.64898/2026.08.11.744104v1?rss=1
2026-08-15doi:10.64898/2026.08.11.744104Cold Spring Harbor Laboratory2026-08-15
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An Integrated Atlas of the Human Kidney Spanning Health and Diseases
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https://www.biorxiv.org/content/10.64898/2026.08.12.744548v1?rss=1
2026-08-14doi:10.64898/2026.08.12.744548Cold Spring Harbor Laboratory2026-08-14
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Host gene-expression signatures accurately distinguish bacterial, viral, and inflammatory diseases in febrile children across multiple cohorts
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https://www.biorxiv.org/content/10.64898/2026.08.11.744042v1?rss=1
2026-08-14doi:10.64898/2026.08.11.744042Cold Spring Harbor Laboratory2026-08-14
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Maternal diet and genetics shape the human milk metabolome
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https://www.biorxiv.org/content/10.64898/2026.08.11.744248v1?rss=1
2026-08-14doi:10.64898/2026.08.11.744248Cold Spring Harbor Laboratory2026-08-14
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Chromosome-level genome assembly of the European leaf-toed gecko, Euleptes europaea
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https://www.biorxiv.org/content/10.64898/2026.08.10.744031v1?rss=1
2026-08-14doi:10.64898/2026.08.10.744031Cold Spring Harbor Laboratory2026-08-14
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CARD:Epi - Contextualizing Antimicrobial Resistance Determinants Using Deep Learning Language Models
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https://www.biorxiv.org/content/10.64898/2026.08.14.744850v1?rss=1
2026-08-14doi:10.64898/2026.08.14.744850Cold Spring Harbor Laboratory2026-08-14
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The relationship of genetic diversity and inbreeding to extinction risk across over 500 vertebrate diploid genomes
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https://www.biorxiv.org/content/10.64898/2026.08.14.744813v1?rss=1
2026-08-14doi:10.64898/2026.08.14.744813Cold Spring Harbor Laboratory2026-08-14