bioRxiv Subject Collection: Genomics
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This feed contains articles for bioRxiv Subject Collection "Genomics"
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X-Y divergence of house fly (Musca domestica) proto-sex chromosomes follows distinct evolutionary trajectories despite residing in the same genome
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https://www.biorxiv.org/content/10.64898/2026.09.26.754726v1?rss=1
2026-10-02doi:10.64898/2026.09.26.754726Cold Spring Harbor Laboratory2026-10-02
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Method-dependent biases in cell type detection between single-cell and single-nucleus RNA sequencing in the photosymbiotic acoel Praesagittifera naikaiensis
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https://www.biorxiv.org/content/10.64898/2026.09.27.754747v1?rss=1
2026-10-02doi:10.64898/2026.09.27.754747Cold Spring Harbor Laboratory2026-10-02
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Genome-wide mapping of endogenous topoisomerase cleavage complexes reveals TOP1 at the interface of DNA topological regulation and genome instability
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https://www.biorxiv.org/content/10.64898/2026.09.30.755763v1?rss=1
2026-10-02doi:10.64898/2026.09.30.755763Cold Spring Harbor Laboratory2026-10-02
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Topoisomerase-mediated resolution of negative DNA supercoiling sustains human transcription and gene activation
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https://www.biorxiv.org/content/10.64898/2026.09.30.755832v1?rss=1
2026-10-02doi:10.64898/2026.09.30.755832Cold Spring Harbor Laboratory2026-10-02
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Applying AlphaGenome Variant Impact for SNV Prioritization
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https://www.biorxiv.org/content/10.64898/2026.09.26.754650v1?rss=1
2026-10-01doi:10.64898/2026.09.26.754650Cold Spring Harbor Laboratory2026-10-01
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Genetic risk and inflammatory signaling converge on cell type-specific regulatory programs in type 1 diabetes
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https://www.biorxiv.org/content/10.64898/2026.09.25.753922v1?rss=1
2026-10-01doi:10.64898/2026.09.25.753922Cold Spring Harbor Laboratory2026-10-01
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Scalable saturation mutagenesis reveals gene regulatory architecture and rare variant effects
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https://www.biorxiv.org/content/10.64898/2026.09.30.755794v1?rss=1
2026-10-01doi:10.64898/2026.09.30.755794Cold Spring Harbor Laboratory2026-10-01
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The Genome In A Bottle HG002 assembly-based variant benchmark set enables comprehensive benchmarking of small and structural variants.
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https://www.biorxiv.org/content/10.64898/2026.09.23.752440v1?rss=1
2026-10-01doi:10.64898/2026.09.23.752440Cold Spring Harbor Laboratory2026-10-01
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Chromosome-level genome assembly of the Olympia oyster (Ostrea lurida), the only oyster species native to the West Coast of North America
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https://www.biorxiv.org/content/10.64898/2026.09.23.753890v1?rss=1
2026-10-01doi:10.64898/2026.09.23.753890Cold Spring Harbor Laboratory2026-10-01
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Factors underlying creativity show distinct genetic architecture and genetic correlations with psychiatric disorders
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https://www.biorxiv.org/content/10.64898/2026.09.30.755774v1?rss=1
2026-09-30doi:10.64898/2026.09.30.755774Cold Spring Harbor Laboratory2026-09-30
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Intelligence and the Big Five personality traits share a genetic and biological basis
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https://www.biorxiv.org/content/10.64898/2026.09.30.755709v1?rss=1
2026-09-30doi:10.64898/2026.09.30.755709Cold Spring Harbor Laboratory2026-09-30
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Genomic structural variation in clownfish adaptive radiation
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https://www.biorxiv.org/content/10.64898/2026.09.25.754321v1?rss=1
2026-09-30doi:10.64898/2026.09.25.754321Cold Spring Harbor Laboratory2026-09-30
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Phylodynamic analysis reveals asymmetric and accelerating global spread of dengue virus
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https://www.biorxiv.org/content/10.64898/2026.09.28.754967v1?rss=1
2026-09-30doi:10.64898/2026.09.28.754967Cold Spring Harbor Laboratory2026-09-30
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Whole-genome characterization of Plasmodium falciparum population structure and drug resistance across Uganda and neighboring countries
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https://www.biorxiv.org/content/10.64898/2026.09.27.754784v1?rss=1
2026-09-30doi:10.64898/2026.09.27.754784Cold Spring Harbor Laboratory2026-09-30
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Rapid whole genome- and annotation-based multilocus sequence typing of the fungal pathogen Histoplasma capsulatum
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https://www.biorxiv.org/content/10.64898/2026.09.27.754713v1?rss=1
8,000 markers. Each of the MLST schemes allowed reproducible separation of all 7 lineages and 6 H. capsulatum Suramericanum sublineages, without the need for high-performance clusters or powerful computing equipment. Comparison of the different schemes using tanglegrams and scatter plots showed good reproducibility (r2 values of 0.8-1.0). Comparison of total sizes of genome assemblies showed significant lineage-dependent size differences, with the Suramericanum, LAmB, India, Capsulatum and Mississippiense lineages averaging a total genome size of 30-33 million bp, and the Africa and Ohiense lineages averaging at 39 million bp. Conclusion. Genome sequence- and especially genome annotation-based MLST analyses are a promising approach that can be adapted as a rapid, high-throughput method for genomic clustering and epidemiological tracing of pathogenic fungi.
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Evo 2 as a classification machine: evidence from in-context learning and mechanistic interpretability
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https://www.biorxiv.org/content/10.64898/2026.09.30.755330v1?rss=1
2026-09-30doi:10.64898/2026.09.30.755330Cold Spring Harbor Laboratory2026-09-30
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Reconstruction of the Prox gene family evolution in vertebrates reveals multiple lineage-specific gene losses
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https://www.biorxiv.org/content/10.64898/2026.09.25.754218v1?rss=1
2026-09-30doi:10.64898/2026.09.25.754218Cold Spring Harbor Laboratory2026-09-30
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Gene flux shapes diversity and evolution of the ancient 17q21.31 inversion polymorphism
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https://www.biorxiv.org/content/10.64898/2026.09.28.755014v1?rss=1
2026-09-30doi:10.64898/2026.09.28.755014Cold Spring Harbor Laboratory2026-09-30
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Integrated transcriptomic analysis identifies Paternally Expressed Gene 10 as a novel candidate biomarker associated with aggressive features in liposarcoma
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https://www.biorxiv.org/content/10.64898/2026.09.24.754104v1?rss=1
2026-09-29doi:10.64898/2026.09.24.754104Cold Spring Harbor Laboratory2026-09-29
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Disease relevance and replicability of deep learning gene expression prediction
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https://www.biorxiv.org/content/10.64898/2026.09.24.753534v1?rss=1
2026-09-29doi:10.64898/2026.09.24.753534Cold Spring Harbor Laboratory2026-09-29
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SCAR: Controlled mutations, ancient DNA damage, and fragmentation of fasta and fastq sequences
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https://www.biorxiv.org/content/10.64898/2026.09.24.754018v1?rss=1
2026-09-29doi:10.64898/2026.09.24.754018Cold Spring Harbor Laboratory2026-09-29
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Alcohol Use Disorder and Smoking-Associated Molecular Alterations in Human Prefrontal Cortex in Single Nucleus (sn) RNA-Seq
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https://www.biorxiv.org/content/10.64898/2026.09.24.753990v1?rss=1
2026-09-29doi:10.64898/2026.09.24.753990Cold Spring Harbor Laboratory2026-09-29
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Evolutionary dynamics of the insertion sequence IS6110 in the Mycobacterium tuberculosis complex
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https://www.biorxiv.org/content/10.64898/2026.09.24.753865v1?rss=1
2026-09-29doi:10.64898/2026.09.24.753865Cold Spring Harbor Laboratory2026-09-29
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Identifying, phasing, and structurally annotating sex chromosomes for genome assemblies using CBS-tools
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https://www.biorxiv.org/content/10.64898/2026.09.23.753885v1?rss=1
2026-09-29doi:10.64898/2026.09.23.753885Cold Spring Harbor Laboratory2026-09-29
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Genomic correlates of metastatic competence and progression in human melanoma
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https://www.biorxiv.org/content/10.64898/2026.09.23.753695v1?rss=1
2026-09-29doi:10.64898/2026.09.23.753695Cold Spring Harbor Laboratory2026-09-29
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PfPHAST: Plasmodium falciparum Public Health Amplicon Sequencing Tool, a Streamlined Panel for Malaria Genomic Surveillance
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https://www.biorxiv.org/content/10.64898/2026.09.26.754026v1?rss=1
2026-09-29doi:10.64898/2026.09.26.754026Cold Spring Harbor Laboratory2026-09-29
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The Flame Retardant Triphenyl Phosphate Induces Varying Responses in Genetically Diverse Mouse Induced Pluripotent Stem Cells
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https://www.biorxiv.org/content/10.64898/2026.09.28.754846v1?rss=1
2026-09-28doi:10.64898/2026.09.28.754846Cold Spring Harbor Laboratory2026-09-28
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Structural polymorphism and population-variable coding capacity of HERV-K(HML-2) in human pangenomes
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https://www.biorxiv.org/content/10.64898/2026.09.22.753638v1?rss=1
2026-09-28doi:10.64898/2026.09.22.753638Cold Spring Harbor Laboratory2026-09-28
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Structural variation in repeat elements is widespread in normal human tissues and in tumorigenesis
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https://www.biorxiv.org/content/10.64898/2026.09.22.753313v1?rss=1
2026-09-28doi:10.64898/2026.09.22.753313Cold Spring Harbor Laboratory2026-09-28
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Whole-Genome Metagenomics Insights Revealed a Uranium Bio-remediating Cross-Domain Microbiome in the Dhala Impact Structure, India
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https://www.biorxiv.org/content/10.64898/2026.09.26.754616v1?rss=1
2026-09-28doi:10.64898/2026.09.26.754616Cold Spring Harbor Laboratory2026-09-28