bioRxiv Subject Collection: Biophysics
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This feed contains articles for bioRxiv Subject Collection "Biophysics"
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Topological defects and coherent myocardial chirality shape torsional heart contraction
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https://www.biorxiv.org/content/10.64898/2026.04.13.718243v1?rss=1
2026-04-16doi:10.64898/2026.04.13.718243Cold Spring Harbor Laboratory2026-04-16
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The dynamic and heterogeneous structure of the non-canonical inflammasome
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https://www.biorxiv.org/content/10.64898/2026.04.15.718739v1?rss=1
2026-04-16doi:10.64898/2026.04.15.718739Cold Spring Harbor Laboratory2026-04-16
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Biomolecular condensates provide a unique environment for redox-mediated protein crosslinking
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https://www.biorxiv.org/content/10.64898/2026.04.14.718453v1?rss=1
2026-04-16doi:10.64898/2026.04.14.718453Cold Spring Harbor Laboratory2026-04-16
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Differential effects of α-Synuclein monomers and seeds on the material properties of Tau condensates
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https://www.biorxiv.org/content/10.64898/2026.04.14.718443v1?rss=1
2026-04-16doi:10.64898/2026.04.14.718443Cold Spring Harbor Laboratory2026-04-16
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Asymmetric Hydration and Protonation Switching of Dual Aspartates Drive Flagellar Rotation
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https://www.biorxiv.org/content/10.64898/2026.04.14.718414v1?rss=1
2026-04-16doi:10.64898/2026.04.14.718414Cold Spring Harbor Laboratory2026-04-16
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Quantitative and mutational analysis of soluble HIV-1 Vpu and calmodulin interactions
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https://www.biorxiv.org/content/10.64898/2026.04.15.718738v1?rss=1
2026-04-16doi:10.64898/2026.04.15.718738Cold Spring Harbor Laboratory2026-04-16
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Protein entanglement misfolding determines divergent fates: proteasomal degradation or persistence in near-native misfolded states
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https://www.biorxiv.org/content/10.64898/2026.04.15.718748v1?rss=1
2026-04-16doi:10.64898/2026.04.15.718748Cold Spring Harbor Laboratory2026-04-16
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Influence of Lipomannan and Lipoarabinomannan Concentration on Mycobacterial Inner Membranes Characterized by All-atom Simulations
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https://www.biorxiv.org/content/10.64898/2026.04.15.718817v1?rss=1
2026-04-16doi:10.64898/2026.04.15.718817Cold Spring Harbor Laboratory2026-04-16
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Resolving the Activation Mechanism of the Human 20S Proteasome
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https://www.biorxiv.org/content/10.64898/2026.04.13.718244v1?rss=1
2026-04-15doi:10.64898/2026.04.13.718244Cold Spring Harbor Laboratory2026-04-15
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Heterotrimeric G proteins exhibit subtype-specific mobility differences in live cells
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https://www.biorxiv.org/content/10.64898/2026.04.13.718213v1?rss=1
2026-04-15doi:10.64898/2026.04.13.718213Cold Spring Harbor Laboratory2026-04-15
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Atomic structure and dynamics of the mechanosensitive channel MscL from E. coli by cryo-EM and solid-state NMR
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https://www.biorxiv.org/content/10.64898/2026.04.14.718163v1?rss=1
2026-04-15doi:10.64898/2026.04.14.718163Cold Spring Harbor Laboratory2026-04-15
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Far-from-equilibrium assembly of multimers through DNA-based catalytic templating
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https://www.biorxiv.org/content/10.64898/2026.04.13.718267v1?rss=1
2026-04-15doi:10.64898/2026.04.13.718267Cold Spring Harbor Laboratory2026-04-15
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From Pixel to Wave: A Geometric Complementary Code for Hierarchical Pixel-Based Morphometry
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https://www.biorxiv.org/content/10.64898/2026.04.13.718311v1?rss=1
2026-04-15doi:10.64898/2026.04.13.718311Cold Spring Harbor Laboratory2026-04-15
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On-lamella super-resolution cryo-CLEM for cryo-ET enabled by vacuum-free ultra-stable cryogenic fluorescence microscopy
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https://www.biorxiv.org/content/10.64898/2026.04.14.717675v1?rss=1
2026-04-15doi:10.64898/2026.04.14.717675Cold Spring Harbor Laboratory2026-04-15
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Single-molecule imaging and tracking on clinical liquid biopsies reveals cancer biomarkers nanoscale organization and heterogeneity
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https://www.biorxiv.org/content/10.64898/2026.04.13.717683v1?rss=1
2026-04-15doi:10.64898/2026.04.13.717683Cold Spring Harbor Laboratory2026-04-15
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Multifractal Fluctuations in Electrogram Dynamics Distinguish Atrial Fibrillation Phenotype, Drug Response, and Imminent Termination: Implications for Mechanism and Treatment.
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https://www.biorxiv.org/content/10.64898/2026.04.12.718068v1?rss=1
1.4 million seconds of high-density bipolar electrograms from 106 patients (paroxysmal n{approx}52, non-paroxysmal n{approx}54) undergoing left atrial mapping with a 24-bipole HD-Grid catheter at standardized sites (RENEWAL AF-ANZCTR ACTRN12619001172190)). Multifractal analysis using the Wavelet Transform Modulus Maxima Method (WTMM) was applied to a burst-energy observable to derive log-normal multifractal parameters c0 (support dimension), c1 (spectrum location), and c2 (fluctuations). Hierarchical mixed-effects models accounted for channels nested within locations within patients. A flecainide sub-study (n=15) provided paired pre/post-infusion recordings, and 27 spontaneous termination events in 15 patients were analysed using 60-s pre-termination windows. Spatial texture of c2 was quantified by variogram-derived correlation length and sill. Results AF electrograms exhibited robust multifractality confirming multifractal fluctuations as an intrinsic property of AF. Non-paroxysmal AF showed significantly reduced fluctuations versus paroxysmal AF (c2: {beta}=-0.01, p=0.001), indicating a paradoxical loss of fluctuations with disease progression. Flecainide selectively increased fluctuations in paroxysmal AF ({Delta}c2 = +0.04, p<0.01; {Delta}c0 = +0.06, p<0.01) but had no significant effect on fluctuations (c2) in non-paroxysmal AF, revealing phenotype-dependent drug response. Immediately prior to spontaneous AF termination, fluctuations increased significantly compared with sustained AF (c2: 0.198 vs 0.181, p=0.024). Spatial variogram analysis revealed heterogenous patterns in paroxysmal AF, whereas non-paroxysmal AF displayed a homogenised, flattened fluctuations landscape. Conclusions Atrial fibrillation exhibits robust multifractal dynamics rather than random electrical activity. Reduced fluctuations characterizes non-paroxysmal AF, whereas higher fluctuations is observed in paroxysmal AF, during flecainide modulation, and immediately prior to spontaneous termination. These findings suggest that multifractal fluctuations (c2) reflects the dynamical state of AF and may serve as a quantitative biomarker of disease progression, pharmacologic responsiveness, and proximity to termination.
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Emergence of rigidity percolation and critical behavior in tunable protein condensates
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https://www.biorxiv.org/content/10.64898/2026.04.13.718064v1?rss=1
2026-04-14doi:10.64898/2026.04.13.718064Cold Spring Harbor Laboratory2026-04-14
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Escherichia coli K12 exhibits a ~50% longer lag phase, but no difference in log phase growth rate, under hypomagnetic conditions (19 nT)
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https://www.biorxiv.org/content/10.64898/2026.04.13.717819v1?rss=1
2026-04-14doi:10.64898/2026.04.13.717819Cold Spring Harbor Laboratory2026-04-14
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Quantifying Mg2+ dependence on conformational equilibrium in the two-state 7SK RNA stem-loop 3
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https://www.biorxiv.org/content/10.64898/2026.04.11.717930v1?rss=1
2026-04-14doi:10.64898/2026.04.11.717930Cold Spring Harbor Laboratory2026-04-14
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Mechanical interaction enables a collective mode of protocell proliferation
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https://www.biorxiv.org/content/10.64898/2026.04.11.717946v1?rss=1
2026-04-14doi:10.64898/2026.04.11.717946Cold Spring Harbor Laboratory2026-04-14
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Engineered Channel Asymmetry Extends Hydrogen-Bonding Networks for Proton Conduction
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https://www.biorxiv.org/content/10.64898/2026.04.11.717926v1?rss=1
2026-04-14doi:10.64898/2026.04.11.717926Cold Spring Harbor Laboratory2026-04-14
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Single-particle light scattering reveals the dynamic heterogeneity of biomolecular condensates
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https://www.biorxiv.org/content/10.64898/2026.04.10.717862v1?rss=1
2026-04-14doi:10.64898/2026.04.10.717862Cold Spring Harbor Laboratory2026-04-14
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Third Harmonic Generation Microscopy Reveals Structure and Mucus Dynamics in Human Airway Epithelium Models
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https://www.biorxiv.org/content/10.64898/2026.04.10.717621v1?rss=1
2026-04-14doi:10.64898/2026.04.10.717621Cold Spring Harbor Laboratory2026-04-14
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How Generative Models Approach Molecular Conformational Sampling
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https://www.biorxiv.org/content/10.64898/2026.04.10.717851v1?rss=1
2026-04-14doi:10.64898/2026.04.10.717851Cold Spring Harbor Laboratory2026-04-14
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Contemporaneity of the past in stochastic intergenerational homeostasis
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https://www.biorxiv.org/content/10.64898/2026.04.10.717806v1?rss=1
2026-04-14doi:10.64898/2026.04.10.717806Cold Spring Harbor Laboratory2026-04-14
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Dynamic myosin 10 coupling to DCC and β1 integrin is mediated by intrinsically disordered regions during filopodial transport and patterning
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https://www.biorxiv.org/content/10.64898/2026.04.10.717811v1?rss=1
2026-04-14doi:10.64898/2026.04.10.717811Cold Spring Harbor Laboratory2026-04-14
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Tau-Mediated Cytoskeletal Stabilization Modulates Cell Mechanics and Vulnerability to Mechanical Strain
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https://www.biorxiv.org/content/10.64898/2026.04.10.717705v1?rss=1
2026-04-14doi:10.64898/2026.04.10.717705Cold Spring Harbor Laboratory2026-04-14
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Mechanical properties of DNA double-crossover motifs
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https://www.biorxiv.org/content/10.64898/2026.04.10.717625v1?rss=1
2026-04-14doi:10.64898/2026.04.10.717625Cold Spring Harbor Laboratory2026-04-14
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Polymorphic structures of rapidly twisting 40-residue amyloid-β fibrils
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https://www.biorxiv.org/content/10.64898/2026.04.10.717728v1?rss=1
2026-04-14doi:10.64898/2026.04.10.717728Cold Spring Harbor Laboratory2026-04-14
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The influence of tension-compression switches on brain anisotropic modelling
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https://www.biorxiv.org/content/10.64898/2026.04.10.717701v1?rss=1
2026-04-14doi:10.64898/2026.04.10.717701Cold Spring Harbor Laboratory2026-04-14