bioRxiv Subject Collection: Biophysics
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This feed contains articles for bioRxiv Subject Collection "Biophysics"
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Towards a database capturing chromosome structure and function: symbols and syntax
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https://www.biorxiv.org/content/10.64898/2026.05.14.724942v1?rss=1
2026-05-14doi:10.64898/2026.05.14.724942Cold Spring Harbor Laboratory2026-05-14
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pH Induced Changes in Protein Structure and Hydration
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https://www.biorxiv.org/content/10.64898/2026.05.13.724817v1?rss=1
2026-05-14doi:10.64898/2026.05.13.724817Cold Spring Harbor Laboratory2026-05-14
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Cryo-EM structure and biochemical characterization of a BRAF/CRAF heterodimer: Negative charge in the NtA motif is not required for RAF activation
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https://www.biorxiv.org/content/10.64898/2026.05.11.724350v1?rss=1
2026-05-14doi:10.64898/2026.05.11.724350Cold Spring Harbor Laboratory2026-05-14
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Structural basis for the intestinal protocadherin-based intermicrovillar adhesion complex
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https://www.biorxiv.org/content/10.64898/2026.05.11.724279v1?rss=1
2026-05-14doi:10.64898/2026.05.11.724279Cold Spring Harbor Laboratory2026-05-14
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RNA synthesis and degradation regulate biomolecular condensates through non-equilibrium feedback
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https://www.biorxiv.org/content/10.64898/2026.05.11.724287v1?rss=1
2026-05-14doi:10.64898/2026.05.11.724287Cold Spring Harbor Laboratory2026-05-14
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Large-domain histology-based diffusion MRI simulation via independent local simulations
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https://www.biorxiv.org/content/10.64898/2026.05.11.724295v1?rss=1
2026-05-14doi:10.64898/2026.05.11.724295Cold Spring Harbor Laboratory2026-05-14
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PolyA/polyQ-mediated conformational rewiring regulates DNA engagement and drives aggregation in the neuronal transcription factor Ascl1
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https://www.biorxiv.org/content/10.64898/2026.05.11.724289v1?rss=1
2026-05-14doi:10.64898/2026.05.11.724289Cold Spring Harbor Laboratory2026-05-14
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Membrane Phase, Charge, and Curvature Regulate α-Synuclein Binding Dynamics
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https://www.biorxiv.org/content/10.64898/2026.05.12.724662v1?rss=1
2026-05-14doi:10.64898/2026.05.12.724662Cold Spring Harbor Laboratory2026-05-14
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Substrate mediated mechanical forces enable optimal kinetic proofreading by T-cell receptors
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https://www.biorxiv.org/content/10.64898/2026.05.12.724610v1?rss=1
2026-05-14doi:10.64898/2026.05.12.724610Cold Spring Harbor Laboratory2026-05-14
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Fungal Hyphae as Distributed Vapor Sinks
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https://www.biorxiv.org/content/10.64898/2026.05.13.724476v1?rss=1
2026-05-14doi:10.64898/2026.05.13.724476Cold Spring Harbor Laboratory2026-05-14
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A workflow for the identification of oligomeric structures on tilted sample planes in Cryo-SMLM
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https://www.biorxiv.org/content/10.64898/2026.05.12.724524v1?rss=1
2026-05-14doi:10.64898/2026.05.12.724524Cold Spring Harbor Laboratory2026-05-14
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Temperature-dependent ligand relocation reveals plasticity of TRPM4 inhibition
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https://www.biorxiv.org/content/10.64898/2026.05.13.724805v1?rss=1
2026-05-14doi:10.64898/2026.05.13.724805Cold Spring Harbor Laboratory2026-05-14
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Transthyretin amyloid fibrils adopt distinct folds in the brain
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https://www.biorxiv.org/content/10.64898/2026.05.12.724695v1?rss=1
2026-05-14doi:10.64898/2026.05.12.724695Cold Spring Harbor Laboratory2026-05-14
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Cellular Mechanisms of Transcranial Magnetic Stimulation in Climbing Fibers and Purkinje Neurons in the Cerebellum
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https://www.biorxiv.org/content/10.64898/2026.05.12.724125v1?rss=1
58 {+/-} 17 V/m), TMS synaptically activated dendritic currents in Purkinje cells. These results provide new insight into how TMS may activate afferent fibers and cell bodies of cortical neurons.
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Kaiso reads methylated CpGs at nucleosome entry/exit and displaces the H3 tail
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https://www.biorxiv.org/content/10.64898/2026.05.10.724166v1?rss=1
2026-05-13doi:10.64898/2026.05.10.724166Cold Spring Harbor Laboratory2026-05-13
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Benchmarking generative AI and physics based molecular simulation for sampling conformational heterogeneity in T4 Lysozyme
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https://www.biorxiv.org/content/10.64898/2026.05.10.724101v1?rss=1
2026-05-13doi:10.64898/2026.05.10.724101Cold Spring Harbor Laboratory2026-05-13
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GluDs are ionotropic dopamine receptors tuned by G-proteins
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https://www.biorxiv.org/content/10.64898/2026.05.10.723887v1?rss=1
2026-05-13doi:10.64898/2026.05.10.723887Cold Spring Harbor Laboratory2026-05-13
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The Conformation of the Complementary Strand and the Deformation of the DNA Groove upon DDB2 Binding Justifies the Different Repair Rates for Cyclobutane Pyrimidine Dimers.
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https://www.biorxiv.org/content/10.64898/2026.05.10.724087v1?rss=1
T, T<>C, C<>T, C<>C), depends on the nucleobases involved in the lesion. TT derivatives (T<>T) are removed more slowly than those containing cytosine, especially in 5'. Using all-atom molecular dynamics simulations and free-energy calculations, we demonstrate that the variation of the repair rate observed in human skin and in cultured cutaneous cell is associated to the recognition of the four lesions by the DDB2 protein moiety, and more specifically by the differential structural deformation induced on the complementary strand. Indeed, while C<>C and C<>T induce a larger deviation on the groove parameters, T<>T and T<>C, instead, affect DNA structure to a lesser extent. less affected. These effects then hamper differentially the downstream recruitment of the repair complexes. The observed DNA deformation correlates with the experimental repair rate and provides a structural rationale for the different repair rates of CPD by nucleotide excision repair machinery.
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Hearts may grow concentrically to balance ATP supply and demand and eccentrically to stabilize titin-based stress
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https://www.biorxiv.org/content/10.64898/2026.05.10.724147v1?rss=1
2026-05-13doi:10.64898/2026.05.10.724147Cold Spring Harbor Laboratory2026-05-13
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Beyond Redfield: Thermodynamic Bounds and Non-Perturbative Quantum Dynamics in Tubulin Networks
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https://www.biorxiv.org/content/10.64898/2026.05.10.724047v1?rss=1
2026-05-13doi:10.64898/2026.05.10.724047Cold Spring Harbor Laboratory2026-05-13
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Proton-coupled alternating access in a versatile Spns drug efflux pump from Mycobacterium smegmatis
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https://www.biorxiv.org/content/10.64898/2026.05.09.724020v1?rss=1
2026-05-13doi:10.64898/2026.05.09.724020Cold Spring Harbor Laboratory2026-05-13
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Sustainable Technology for the Fabrication of Liposomal Phases
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https://www.biorxiv.org/content/10.64898/2026.05.09.724055v1?rss=1
2026-05-13doi:10.64898/2026.05.09.724055Cold Spring Harbor Laboratory2026-05-13
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Benthic diatoms navigate shear flows via hydrodynamic rolling and active gliding
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https://www.biorxiv.org/content/10.64898/2026.05.09.721219v1?rss=1
2026-05-13doi:10.64898/2026.05.09.721219Cold Spring Harbor Laboratory2026-05-13
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Dual curvature sensing governs cell orientation and curvotaxis
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https://www.biorxiv.org/content/10.64898/2026.05.09.723774v1?rss=1
2026-05-13doi:10.64898/2026.05.09.723774Cold Spring Harbor Laboratory2026-05-13
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AI-discovered protein fragments as generalizable regulators of biomolecular condensates
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https://www.biorxiv.org/content/10.64898/2026.05.08.723928v1?rss=1
2026-05-12doi:10.64898/2026.05.08.723928Cold Spring Harbor Laboratory2026-05-12
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Repulsion-Driven Layering in Polymer-Assisted Condensation
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https://www.biorxiv.org/content/10.64898/2026.05.08.723821v1?rss=1
2026-05-12doi:10.64898/2026.05.08.723821Cold Spring Harbor Laboratory2026-05-12
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Optical single-channel recording of CRAC channels with HaloTag and a Ca2+-sensitive ligand
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https://www.biorxiv.org/content/10.64898/2026.05.08.723778v1?rss=1
2026-05-12doi:10.64898/2026.05.08.723778Cold Spring Harbor Laboratory2026-05-12
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Using iPALM to determine protein organisation in cardiac muscle Z-discs
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https://www.biorxiv.org/content/10.64898/2026.05.08.723761v1?rss=1
2026-05-12doi:10.64898/2026.05.08.723761Cold Spring Harbor Laboratory2026-05-12
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Yoda molecules agonize PIEZO2
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https://www.biorxiv.org/content/10.64898/2026.05.08.723777v1?rss=1
2026-05-12doi:10.64898/2026.05.08.723777Cold Spring Harbor Laboratory2026-05-12
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Non-covalent reversibly photoconvertible fluorescent tags for wash-free protein labeling
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https://www.biorxiv.org/content/10.64898/2026.05.08.723694v1?rss=1
2026-05-12doi:10.64898/2026.05.08.723694Cold Spring Harbor Laboratory2026-05-12