bioRxiv Channel: IGC (Instituto Gulbenkian de Ciência) https://biorxiv.org This feed contains articles for bioRxiv Channel "IGC (Instituto Gulbenkian de Ciência) " bioRxiv bioRxiv https://biorxiv.org <![CDATA[ ZeroCostDL4Mic: an open platform to simplify access and use of Deep-Learning in Microscopy ]]> https://biorxiv.org/cgi/content/short/2020.03.20.000133v1?rss=1" Chamier, L. v. Jukkala, J. Spahn, C. Lerche, M. Hernandez-perez, S. Mattila, P. Karinou, E. Holden, S. Can Solak, A. Krull, A. Buchholz, T.-O. Jug, F. Royer, L. A. Heilemann, M. Laine, R. F. Jacquemet, G. Henriques, R. 2020-03-20 doi:10.1101/2020.03.20.000133 Cold Spring Harbor Laboratory Press 2020-03-20 <![CDATA[ Single-molecule super-resolution imaging of T-cell plasma membrane CD4 redistribution upon HIV-1 binding ]]> https://biorxiv.org/cgi/content/short/2021.01.05.425371v1?rss=1" Yuan, Y. Jacobs, C. Llorente Garcia, I. Pereira, P. M. Lawrence, S. Laine, R. F. Marsh, M. Henriques, R. 2021-01-05 doi:10.1101/2021.01.05.425371 Cold Spring Harbor Laboratory Press 2021-01-05 <![CDATA[ The 3D architecture and molecular foundations of de novo centriole assembly via bicentrioles ]]> https://biorxiv.org/cgi/content/short/2020.12.21.423647v1?rss=1" Gomes Pereira, S. Sousa, A. L. Nabais, C. Paixão, T. Holmes, A. J. Schorb, M. Goshima, G. Tranfield, E. M. Becker, J. D. Bettencourt-Dias, M. 2020-12-22 doi:10.1101/2020.12.21.423647 Cold Spring Harbor Laboratory Press 2020-12-22 <![CDATA[ Aster repulsion drives local ordering in an active system ]]> https://biorxiv.org/cgi/content/short/2020.06.04.133579v1?rss=1" de-Carvalho, J. Tlili, S. Hufnagel, L. Saunders, T. E. Telley, I. A. 2020-06-05 doi:10.1101/2020.06.04.133579 Cold Spring Harbor Laboratory Press 2020-06-05 <![CDATA[ Self-renewal capacity of double negative 3 (DN3) early thymocytes preserves thymus autonomous function but compromises the β-selection checkpoint ]]> https://biorxiv.org/cgi/content/short/2020.06.09.142596v1?rss=1" Paiva, R. A. Sousa, A. G. Ramos, C. V. Avila, M. Lilue, J. Paixao, T. Martins, V. C. 2020-06-10 doi:10.1101/2020.06.09.142596 Cold Spring Harbor Laboratory Press 2020-06-10 <![CDATA[ High Epha1 expression is a potential cell surface marker for embryonic neuro-mesodermal progenitors ]]> https://biorxiv.org/cgi/content/short/584524v1?rss=1" de Lemos, L. Novoa, A. Mallo, M. 2019-03-21 doi:10.1101/584524 Cold Spring Harbor Laboratory Press 2019-03-21 <![CDATA[ Trem-2 modulation of gut microbiota is blunted during hepatotoxic injury and uncoupled from liver repair responses ]]> https://biorxiv.org/cgi/content/short/857078v1?rss=1" Coelho, I. Duarte, N. Macedo, M. P. Penha-Goncalves, C. 2019-11-28 doi:10.1101/857078 Cold Spring Harbor Laboratory Press 2019-11-28 <![CDATA[ Developmental effects of oxytocin neurons on social affiliation and processing of social information ]]> https://biorxiv.org/cgi/content/short/2020.10.08.330993v1?rss=1" Nunes, A. R. Gliksberg, M. Varela, S. A. M. Teles, M. Wircer, E. Blechman, J. Petri, G. Levkowitz, G. Oliveira, R. F. 2020-10-08 doi:10.1101/2020.10.08.330993 Cold Spring Harbor Laboratory Press 2020-10-08 <![CDATA[ IFT88 transports Gucy2d, a guanylyl cyclase, to maintain sensory cilia function in Drosophila ]]> https://biorxiv.org/cgi/content/short/2020.12.15.417840v1?rss=1" Werner, S. Zitouni, S. Okenve-Ramos, P. Mendonca, S. Sporbert, A. Spalthoff, C. Gopfert, M. C. Jana, S. C. Bettencourt-Dias, M. 2020-12-15 doi:10.1101/2020.12.15.417840 Cold Spring Harbor Laboratory Press 2020-12-15 <![CDATA[ Genetic variation in the social environment affects behavioral phenotypes of oxytocin receptor mutants in zebrafish ]]> https://biorxiv.org/cgi/content/short/2020.03.23.002873v1?rss=1" Nunes, A. R. Teles, M. Anbalagan, S. Blechman, J. Levkowitz, G. Oliveira, R. F. 2020-03-26 doi:10.1101/2020.03.23.002873 Cold Spring Harbor Laboratory Press 2020-03-26 <![CDATA[ Regulation of Wolbachia proliferation by the amplification and deletion of an addictive genomic island ]]> https://biorxiv.org/cgi/content/short/2020.09.08.288217v1?rss=1" Duarte, E. H. Carvalho, A. Lopez-Madrigal, S. Teixeira, L. 2020-09-08 doi:10.1101/2020.09.08.288217 Cold Spring Harbor Laboratory Press 2020-09-08 <![CDATA[ Comparative transcriptomic analysis reveals conserved transcriptional programs underpinning organogenesis and reproduction in land plants ]]> https://biorxiv.org/cgi/content/short/2020.10.29.361501v1?rss=1" Julca, I. Flores, M. Proost, S. Lindner, A.-C. Hackenberg, D. Steinbachova, L. Michaelidis, C. Gomes Pereira, S. Misra, C. S. Kawashima, T. Borg, M. Berger, F. Goldberg, J. Johnson, M. Honys, D. Twell, D. Sprunck, S. Dresselhaus, T. Becker, J. Mutwil, M. 2020-10-30 doi:10.1101/2020.10.29.361501 Cold Spring Harbor Laboratory Press 2020-10-30 <![CDATA[ Molecular signatures of resource competition: clonal interference drives the emergence of ecotypes ]]> https://biorxiv.org/cgi/content/short/2020.11.20.391151v1?rss=1" Amicone, M. Gordo, I. 2020-11-20 doi:10.1101/2020.11.20.391151 Cold Spring Harbor Laboratory Press 2020-11-20 <![CDATA[ Trem-2 promotes emergence of restorative macrophages and endothelial cells during recovery from hepatic tissue damage. ]]> https://biorxiv.org/cgi/content/short/823773v1?rss=1" Coelho, I. Duarte, N. Barros, A. Macedo, M. P. Penha-Goncalves, C. 2019-10-30 doi:10.1101/823773 Cold Spring Harbor Laboratory Press 2019-10-30 <![CDATA[ Alternative splicing landscapes in Arabidopsis thaliana across tissues and stress conditions highlight major functional differences with animals ]]> https://biorxiv.org/cgi/content/short/2020.11.10.374751v1?rss=1" Martin, G. Marquez, Y. Mantica, F. Paula, D. Irimia, M. 2020-11-11 doi:10.1101/2020.11.10.374751 Cold Spring Harbor Laboratory Press 2020-11-11 <![CDATA[ Multiple pathways to homothallism in closely related yeast lineages in the Basidiomycota ]]> https://biorxiv.org/cgi/content/short/2020.09.30.320192v1?rss=1" Cabrita, A. David-Palma, M. Brito, P. H. Heitman, J. Coelho, M. A. Goncalves, P. 2020-09-30 doi:10.1101/2020.09.30.320192 Cold Spring Harbor Laboratory Press 2020-09-30 <![CDATA[ Cell competition regulates the kinetics of thymopoiesis and thymus cellularity ]]> https://biorxiv.org/cgi/content/short/2019.12.21.885673v1?rss=1" Ramos, C. V. Ballesteros-Arias, L. Silva, J. G. Nogueira, M. Gjini, E. Martins, V. C. 2019-12-23 doi:10.1101/2019.12.21.885673 Cold Spring Harbor Laboratory Press 2019-12-23 <![CDATA[ Muller’s Ratchet and the Long-Term Fate of Chromosomal Inversions ]]> https://biorxiv.org/cgi/content/short/606012v1?rss=1" Berdan, E. Blanckaert, A. Butlin, R. K. Bank, C. 2019-04-13 doi:10.1101/606012 Cold Spring Harbor Laboratory Press 2019-04-13 <![CDATA[ CXCL5-mediated recruitment of neutrophils into the peritoneal cavity of Gdf15-deficient mice protects against abdominal sepsis ]]> https://biorxiv.org/cgi/content/short/613901v1?rss=1" Santos, I. Colaco, H. G. Neves-Costa, A. Seixas, E. Velho, T. R. Pedroso, D. Barros, A. Martins, R. Weiss, S. Payen, D. Weiss, S. Yi, H.-S. Shong, M. Moita, L. F. 2019-04-19 doi:10.1101/613901 Cold Spring Harbor Laboratory Press 2019-04-19 <![CDATA[ Expression of Castanea crenata Allene Oxide Synthase in Arabidopsis Improves the Defense to Phytophthora cinnamomi ]]> https://biorxiv.org/cgi/content/short/2020.10.09.333781v1?rss=1" Serrazina, S. M. Machado, H. Costa, R. Duque, P. Malho, R. M. 2020-10-12 doi:10.1101/2020.10.09.333781 Cold Spring Harbor Laboratory Press 2020-10-12 <![CDATA[ Wolbachia and host intrinsic reproductive barriers contribute additively to post-mating isolation in spider mites ]]> https://biorxiv.org/cgi/content/short/2020.06.29.178699v1?rss=1" Cruz, M. A. Magalhaes, S. Sucena, E. Zele, F. 2020-07-05 doi:10.1101/2020.06.29.178699 Cold Spring Harbor Laboratory Press 2020-07-05 <![CDATA[ A first-takes-all model of centriole copy number control ]]> https://biorxiv.org/cgi/content/short/2020.09.23.309567v1?rss=1" Dias Louro, M. A. Bettencourt-Dias, M. Carneiro, J. 2020-09-23 doi:10.1101/2020.09.23.309567 Cold Spring Harbor Laboratory Press 2020-09-23 <![CDATA[ Plk4 triggers autonomous de novo centriole biogenesis and maturation ]]> https://biorxiv.org/cgi/content/short/2020.04.29.068650v1?rss=1" Nabais, C. Pessoa, D. de-Carvalho, J. van Zanten, T. Duarte, P. Mayor, S. Carneiro, J. Telley, I. A. Bettencourt Dias, M. 2020-04-30 doi:10.1101/2020.04.29.068650 Cold Spring Harbor Laboratory Press 2020-04-30 <![CDATA[ Ecdysone coordinates plastic growth with robust pattern in the developing wing ]]> https://biorxiv.org/cgi/content/short/2020.12.16.423141v1?rss=1" Nogueira Alves, A. Oliveira, M. M. Koyama, T. Shingleton, A. Mirth, C. 2020-12-16 doi:10.1101/2020.12.16.423141 Cold Spring Harbor Laboratory Press 2020-12-16 <![CDATA[ Astral microtubule crosslinking by Feo safeguards uniform nuclear distribution in the Drosophila syncytium ]]> https://biorxiv.org/cgi/content/short/859975v1?rss=1" Deshpande, O. de-Carvalho, J. Vieira, D. M. Telley, I. A. 2019-11-29 doi:10.1101/859975 Cold Spring Harbor Laboratory Press 2019-11-29 <![CDATA[ Quantifying the interplay between rapid bacterial evolution within the mouse intestine and transmission between hosts ]]> https://biorxiv.org/cgi/content/short/2020.12.04.412072v1?rss=1" Vasquez, K. S. Willis, L. Cira, N. Ng, K. M. Pedro, M. F. Aranda-Diaz, A. Rajendram, M. Yu, F. B. Higginbottom, S. K. Neff, N. Sherlock, G. Xavier, K. B. Quake, S. Sonnenburg, J. Good, B. H. Huang, K. C. 2020-12-05 doi:10.1101/2020.12.04.412072 Cold Spring Harbor Laboratory Press 2020-12-05 <![CDATA[ The proficiency of the original host species determines community-level plasmid dynamics ]]> https://biorxiv.org/cgi/content/short/2020.10.13.337451v1?rss=1" Kottara, A. Hall, J. Brockhurst, M. 2020-10-13 doi:10.1101/2020.10.13.337451 Cold Spring Harbor Laboratory Press 2020-10-13 <![CDATA[ Metabolomic signature of the maternal microbiota in the fetus ]]> https://biorxiv.org/cgi/content/short/2020.09.28.317081v1?rss=1" Pessa-Morikawa, T. Husso, A. Kärkkäinen, O. Koistinen, V. Iivanainen, A. Niku, M. 2020-09-29 doi:10.1101/2020.09.28.317081 Cold Spring Harbor Laboratory Press 2020-09-29 <![CDATA[ Heterotrimeric kinesin-2 motor subunit, KLP68D, localises Drosophila odour receptor coreceptor in the distal domain of the olfactory cilia ]]> https://biorxiv.org/cgi/content/short/2020.11.24.395905v1?rss=1" View larger version (69K): org.highwire.dtl.DTLVardef@177d376org.highwire.dtl.DTLVardef@1dc14d6org.highwire.dtl.DTLVardef@1dc2d21org.highwire.dtl.DTLVardef@16e90c_HPS_FORMAT_FIGEXP M_FIG C_FIG Author SummaryJana, Jain, Dutta et al., show that the odour receptor coreceptor only enters the cilia expressed on olfactory sensory neurons at specified developmental stages requiring heterotrimeric kinesin-2. The motor also helps to localise the coreceptor in a compact, environment-exposed domain at the ciliary outer-segment. HighlightsO_LIOdorant receptor coreceptor (Orco) selectively enters the olfactory cilia. C_LIO_LIOrco localises in a specific domain at the distal segment of the olfactory cilium. C_LIO_LIOrco/ORx binds to the C-terminal tail domain of the kinesin-2{beta} motor subunit. C_LIO_LIOrco entry across the transition zone and its positioning require Kinesin-2. C_LI ]]> Jana, S. C. Jain, A. Dutta, P. Singh, A. Adusumilli, L. Girotra, M. Shirolikar, S. Ray, K. 2020-11-24 doi:10.1101/2020.11.24.395905 Cold Spring Harbor Laboratory Press 2020-11-24 <![CDATA[ Reprogramming of Human Cells to Pluripotency Induces CENP-A Chromatin Depletion ]]> https://biorxiv.org/cgi/content/short/2020.02.21.960252v1?rss=1" Milagre, I. Pereira, C. Oliveira, R. Jansen, L. E. T. 2020-02-22 doi:10.1101/2020.02.21.960252 Cold Spring Harbor Laboratory Press 2020-02-22 <![CDATA[ DNA damage independent inhibition of NF-κB transcription by anthracyclines ]]> https://biorxiv.org/cgi/content/short/2020.04.27.065003v1?rss=1" Chora, A. Pedroso, D. Pejanovic, N. Kyriakou, E. Colaco, H. Gozzelino, R. Barros, A. Willmann, K. Velho, T. Moita, C. Santos, I. Carvalho, S. Martins, F. Ferreira, J. Almeida, S. Benes, V. Anrather, J. Soares, M. Geerlof, A. Neefjes, J. Sattler, M. Messias, A. Neves-Costa, A. Moita, L. F. 2020-04-29 doi:10.1101/2020.04.27.065003 Cold Spring Harbor Laboratory Press 2020-04-29 <![CDATA[ DNA breaks are key contributors to the cost of antibiotic resistance ]]> https://biorxiv.org/cgi/content/short/756767v1?rss=1" Balbontin, R. Gordo, I. 2019-09-05 doi:10.1101/756767 Cold Spring Harbor Laboratory Press 2019-09-05 <![CDATA[ Gut cancer increases the risk for Drosophila to be preyed upon by hunting spiders in the laboratory ]]> https://biorxiv.org/cgi/content/short/2020.07.01.182824v1?rss=1" duneau, d. Buchon, N. 2020-07-02 doi:10.1101/2020.07.01.182824 Cold Spring Harbor Laboratory Press 2020-07-02 <![CDATA[ Step-specific adaptation and trade-off over the course of an infection by GASP-mutation small colony variants ]]> https://biorxiv.org/cgi/content/short/2020.05.28.122713v1?rss=1" Faucher, C. Mazana, V. Kardacz, M. Parthuisot, N. Ferdy, J.-B. duneau, d. 2020-05-31 doi:10.1101/2020.05.28.122713 Cold Spring Harbor Laboratory Press 2020-05-31 <![CDATA[ Telomere shortening produces an inflammatory environment that promotes tumor invasiveness in zebrafish ]]> https://biorxiv.org/cgi/content/short/844084v1?rss=1" Lex, K. Gil, M. M. Figueira, M. Marzullo, M. Lopes-Bastos, B. Giannetti, K. Carvalho, T. G. Ferreira, M. G. 2019-11-15 doi:10.1101/844084 Cold Spring Harbor Laboratory Press 2019-11-15 <![CDATA[ Environment and sex control lifespan and telomere length in wild-derived African killifish ]]> https://biorxiv.org/cgi/content/short/2020.09.03.280792v1?rss=1" Reichard, M. Giannetti, K. Ferreira, T. Vrtilek, M. Polacik, M. Blazek, R. Ferreira, M. G. 2020-09-03 doi:10.1101/2020.09.03.280792 Cold Spring Harbor Laboratory Press 2020-09-03 <![CDATA[ A weak Foxp3 hypomorph enhances spontaneous and therapeutic immune surveillance of cancer in mice ]]> https://biorxiv.org/cgi/content/short/570671v1?rss=1" Almeida-Santos, J. Bergman, M.-L. Cabral, I. A. Correia, V. Caramalho, I. Demengeot, J. 2019-03-07 doi:10.1101/570671 Cold Spring Harbor Laboratory Press 2019-03-07 <![CDATA[ A TRADE-OFF BETWEEN RESISTANCE TO INFECTION AND REPRODUCTION IN PRIMATE EVOLUTION ]]> https://biorxiv.org/cgi/content/short/2020.07.10.186742v1?rss=1" Sumnima Singh Jessica A. Thompson Sebastian Weis Daniel Sobral Mauro Truglio Bahtiyar Yilmaz Sofia Rebelo Silvia Cardoso Erida Gjini Gabriel Nunez Miguel P. Soares 2020-07-12 doi:10.1101/2020.07.10.186742 Cold Spring Harbor Laboratory Press 2020-07-12 <![CDATA[ Local genetic context shapes the function of a gene regulatory network ]]> https://biorxiv.org/cgi/content/short/2021.01.10.426121v1?rss=1" Nagy-Staron, A. Tomasek, K. Caruso Carter, C. Sonnleitner, E. Kavcic, B. Paixao, T. Guet, C. C. 2021-01-11 doi:10.1101/2021.01.10.426121 Cold Spring Harbor Laboratory Press 2021-01-11 <![CDATA[ Asymmetric neurogenic commitment of retinal progenitors is regulated via the Notch endocytic pathway ]]> https://biorxiv.org/cgi/content/short/2020.06.30.179499v1?rss=1" Nerli, E. Rocha-Martins, M. Norden, C. 2020-07-01 doi:10.1101/2020.06.30.179499 Cold Spring Harbor Laboratory Press 2020-07-01 <![CDATA[ Low Mutational Load Allows for High Mutation Rate Variation in Gut Commensal Bacteria ]]> https://biorxiv.org/cgi/content/short/568709v1?rss=1" 1000 generations, with coexistence between lineages carrying 4 to >600 mutations. This in vivo molecular evolution pattern is consistent with deleterious mutations of ~0.01-0.001% fitness effects, 100 to 1000-fold lower than current in vitro estimates. Despite large numbers of deleterious mutations, we identify multiple beneficial mutations that do not reach fixation over long periods of time. This indicates that the dynamics of beneficial mutations are not shaped by constant positive Darwinian selection but by processes leading to negative frequency-dependent or temporally fluctuating selection. Thus, microbial evolution in the gut is likely characterized by partial sweeps of beneficial mutations combined with hitchhiking of very slightly deleterious mutations, which take a long time to be purged but impose a very weak mutational load. These results are consistent with the pattern of genetic polymorphism that is emerging from metagenomics studies of the human gut microbiota, suggesting that we identified key evolutionary processes shaping the genetic composition of this community. ]]> Ramiro, R. S. Durao, P. Bank, C. Gordo, I. 2019-03-05 doi:10.1101/568709 Cold Spring Harbor Laboratory Press 2019-03-05 <![CDATA[ Bidirectional neuronal migration coordinates retinal morphogenesis bypreventing spatial competition ]]> https://biorxiv.org/cgi/content/short/2021.02.08.430189v1?rss=1" Rocha-Martins, M. Kretzschmar, J. Nerli, E. Weigert, M. Icha, J. Myers, E. W. Norden, C. 2021-02-08 doi:10.1101/2021.02.08.430189 Cold Spring Harbor Laboratory Press 2021-02-08 <![CDATA[ Viral route of infection determines the effect of Drosophila melanogaster gut bacteria on host resistance and tolerance to disease. ]]> https://biorxiv.org/cgi/content/short/2021.02.18.431843v1?rss=1" Landum, M. Silva, M. S. Martins, N. Teixeira, L. 2021-02-18 doi:10.1101/2021.02.18.431843 Cold Spring Harbor Laboratory Press 2021-02-18 <![CDATA[ Epigenetic switching outcompetes genetic mutations during adaptation to fluctuating environments ]]> https://biorxiv.org/cgi/content/short/2021.03.11.434930v1?rss=1" Stajic, D. Bank, C. Gordo, I. 2021-03-12 doi:10.1101/2021.03.11.434930 Cold Spring Harbor Laboratory Press 2021-03-12 <![CDATA[ In silico logical modelling to uncover cooperative interactions in cancer ]]> https://biorxiv.org/cgi/content/short/2021.03.11.434958v1?rss=1" Selvaggio, G. Chaouiya, C. Janody, F. 2021-03-12 doi:10.1101/2021.03.11.434958 Cold Spring Harbor Laboratory Press 2021-03-12 <![CDATA[ Amino acids 484 and 494 of SARS-CoV-2 spike are hotspots of immune evasion affecting antibody but not ACE2 binding ]]> https://biorxiv.org/cgi/content/short/2021.04.22.441007v1?rss=1" Alenquer, M. Ferreira, F. Lousa, D. Valerio, M. Medina-Lopes, M. Bergman, M.-L. Goncalves, J. Demengeot, J. Leite, R. B. Lilue, J. Ning, Z. Penha-Goncalves, C. Soares, H. Soares, C. Amorim, M. J. 2021-04-22 doi:10.1101/2021.04.22.441007 Cold Spring Harbor Laboratory Press 2021-04-22 <![CDATA[ Drosophila Evolution over Space and Time (DEST) - A New Population Genomics Resource ]]> https://biorxiv.org/cgi/content/short/2021.02.01.428994v1?rss=1" 20 countries on four continents based on a combination of 121 unpublished and 150 previously published genomic datasets. Several of these locations have been sampled at different seasons across multiple years. This dataset, which we call Drosophila Evolution over Space and Time (DEST), is coupled with sampling and environmental meta-data. A web-based genome browser and web portal provide easy access to the SNP dataset. Our aim is to provide this scalable platform as a community resource which can be easily extended via future efforts for an even more extensive cosmopolitan dataset. Our resource will enable population geneticists to analyze spatio-temporal genetic patterns and evolutionary dynamics of D. melanogaster populations in unprecedented detail. ]]> Kapun, M. Nunez, J. C. B. Bogaerts-Marquez, M. Murga-Moreno, J. Paris, M. Outten, J. Coronado-Zamora, M. Tern, C. Rota-Stabelli, O. Garcia Guerreiro, M. P. P. Casillas, S. Orengo, D. J. Puerma, E. Kankare, M. Ometto, L. Loeschcke, V. V. Onder, B. S. Abbott, J. K. Schaeffer, S. W. Rajpurohit, S. Behrman, E. L. Schou, M. F. Merritt, T. J. S. Lazzaro, B. P. B. Glaser-Schmitt, A. Argyridou, E. Staubach, F. Wang, Y. Tauber, E. Serga, S. V. Fabian, D. K. Dyer, K. A. Wheat, C. W. Parsch, J. Grath, S. Savic Veselinovic, M. Stamenkovic-Radak, M. Jelic, M. Buendia-R 2021-02-01 doi:10.1101/2021.02.01.428994 Cold Spring Harbor Laboratory Press 2021-02-01 <![CDATA[ Mutation rate of SARS-CoV-2 and emergence of mutators during experimental evolution ]]> https://biorxiv.org/cgi/content/short/2021.05.19.444774v1?rss=1" Borges, V. Alves, M. J. Amicone, M. Isidro, J. Ze-Ze, L. Duarte, S. Vieira, L. Guiomar, R. Gomes, J. P. Gordo, I. 2021-05-19 doi:10.1101/2021.05.19.444774 Cold Spring Harbor Laboratory Press 2021-05-19 <![CDATA[ Co-option of local and systemic immune responses by the hormonal signalling system triggering metamorphosis ]]> https://biorxiv.org/cgi/content/short/2021.05.22.444626v1?rss=1" Nunes, C. Koyama, T. Sucena, E. 2021-05-23 doi:10.1101/2021.05.22.444626 Cold Spring Harbor Laboratory Press 2021-05-23 <![CDATA[ Mathematical model reveals that heterogeneity in the number of ion transporters regulates the fraction of mouse sperm capacitation ]]> https://biorxiv.org/cgi/content/short/2021.02.04.429865v1?rss=1" Aguado-Garcia, A. Priego Espinosa, D. A. Aldana, A. Darszon, A. Martinez-Mekler, G. 2021-02-05 doi:10.1101/2021.02.04.429865 Cold Spring Harbor Laboratory Press 2021-02-05 <![CDATA[ Heterogeneity in effective size across the genome: effects on the Inverse Instantaneous Coalescence Rate (IICR) and implications for demographic inference under linked selection. ]]> https://biorxiv.org/cgi/content/short/2021.06.11.448122v1?rss=1" Boitard, S. Arredondo, A. Nous, C. Chikhi, L. Mazet, O. 2021-06-13 doi:10.1101/2021.06.11.448122 Cold Spring Harbor Laboratory Press 2021-06-13 <![CDATA[ Myosin VI regulates ciliogenesis by promoting the turnover of the centrosomal/satellite protein OFD1 ]]> https://biorxiv.org/cgi/content/short/2021.06.18.448975v1?rss=1" Magistrati, E. Maestrini, G. Lince-Faria, M. Beznoussenko, G. Mironov, A. Maspero, E. Bettencourt Dias, M. Polo, S. 2021-06-19 doi:10.1101/2021.06.18.448975 Cold Spring Harbor Laboratory Press 2021-06-19 <![CDATA[ Extracellular mechanical forces drive endocardial cell volume decrease during cardiac valve morphogenesis ]]> https://biorxiv.org/cgi/content/short/2021.07.27.453460v1?rss=1" Vermot, J. Vignes, H. Vagena-Pantoula, C. Prakash, M. Norden, C. Jug, F. 2021-07-27 doi:10.1101/2021.07.27.453460 Cold Spring Harbor Laboratory Press 2021-07-27 <![CDATA[ Phenotypic architecture of sociality and its associated genetic polymorphisms in zebrafish ]]> https://biorxiv.org/cgi/content/short/2021.07.29.454277v1?rss=1" Oliveira, R. F. Goncalves, C. Kareklas, K. Teles, M. C. Varela, S. A. M. Costa, J. Leite, R. B. Paixao, T. 2021-07-30 doi:10.1101/2021.07.29.454277 Cold Spring Harbor Laboratory Press 2021-07-30 <![CDATA[ Inferring inter- and intrachromosomal Dobzhansky-Muller incompatibilities from imbalanced segregation of recombinant haplotypes in hybrid populations ]]> https://biorxiv.org/cgi/content/short/2021.08.04.454891v1?rss=1" Li, J. Schumer, M. Bank, C. 2021-08-05 doi:10.1101/2021.08.04.454891 Cold Spring Harbor Laboratory Press 2021-08-05 <![CDATA[ Microtubule deacetylation reduces cell stiffness to allow the onset of collective cell migration in vivo ]]> https://biorxiv.org/cgi/content/short/2021.08.12.456059v1?rss=1" Marchant, C. L. Malmi-Kakkada, A. N. Espina, J. A. Barriga, E. H. 2021-08-12 doi:10.1101/2021.08.12.456059 Cold Spring Harbor Laboratory Press 2021-08-12 <![CDATA[ The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians ]]> https://biorxiv.org/cgi/content/short/2021.09.08.459166v1?rss=1" Spruce, T. Plass, M. Gohr, A. Ray, D. Martinez de Lagran, M. Rot, G. Novoa, A. Burguera, D. Permanyer, J. Miret, M. Zheng, H. Swanson, M. Morris, Q. Mallo, M. Dierssen, M. Hughes, T. R. Pernaute, B. Irimia, M. 2021-09-09 doi:10.1101/2021.09.08.459166 Cold Spring Harbor Laboratory Press 2021-09-09 <![CDATA[ Oxytocin regulation of social transmission of fear in zebrafish reveals its evolutionary conserved role in emotional contagion ]]> https://biorxiv.org/cgi/content/short/2021.10.06.463413v1?rss=1" Akinrinade, I. Kareklas, K. Gliksberg, M. Petri, G. Levkowitz, G. Oliveira, R. 2021-10-06 doi:10.1101/2021.10.06.463413 Cold Spring Harbor Laboratory Press 2021-10-06 <![CDATA[ Social and asocial learning in zebrafish are encoded by a shared brain network that is differentially modulated by local activation ]]> https://biorxiv.org/cgi/content/short/2021.10.12.464038v1?rss=1" Pinho, J. Cunliffe, V. T. Petri, G. Oliveira, R. 2021-10-13 doi:10.1101/2021.10.12.464038 Cold Spring Harbor Laboratory Press 2021-10-13 <![CDATA[ Interleukin 7 receptor drives Early T lineage Progenitor expansion ]]> https://biorxiv.org/cgi/content/short/2021.10.23.465581v1?rss=1" Paiva, R. A. Martins, V. C. 2021-10-24 doi:10.1101/2021.10.23.465581 Cold Spring Harbor Laboratory Press 2021-10-24 <![CDATA[ DeepBacs: Bacterial image analysis using open-source deep learning approaches ]]> https://biorxiv.org/cgi/content/short/2021.11.03.467152v1?rss=1" Spahn, C. Laine, R. F. Pereira, P. M. Gomez-de-Mariscal, E. von Chamier, L. Conduit, M. Pinho, M. G. Holden, S. Jacquemet, G. Heilemann, M. Henriques, R. 2021-11-03 doi:10.1101/2021.11.03.467152 Cold Spring Harbor Laboratory Press 2021-11-03 <![CDATA[ Transient dopamine neuron activity precedes and encodes the vigor of contralateral movements ]]> https://biorxiv.org/cgi/content/short/2021.04.20.440527v1?rss=1" Mendonca, M. D. Alves da Silva, J. Hernandez, L. F. Castela, I. Obeso, J. Costa, R. M. 2021-04-20 doi:10.1101/2021.04.20.440527 Cold Spring Harbor Laboratory Press 2021-04-20 <![CDATA[ A within-host infection model to explore tolerance andresistance ]]> https://biorxiv.org/cgi/content/short/2021.10.19.464998v1?rss=1" Pierre, L. Christine, L. Parthuisot, N. Faucher, C. FERDY, J.-B. duneau, d. 2021-10-20 doi:10.1101/2021.10.19.464998 Cold Spring Harbor Laboratory Press 2021-10-20 <![CDATA[ Challenges and pitfalls of inferring microbial growth rates from lab cultures ]]> https://biorxiv.org/cgi/content/short/2022.06.24.497412v1?rss=1" Ghenu, A.-H. Marrec, L. Bank, C. 2022-06-25 doi:10.1101/2022.06.24.497412 Cold Spring Harbor Laboratory Press 2022-06-25 <![CDATA[ Evolutionary models predict potential mechanisms of escape from mutational meltdown ]]> https://biorxiv.org/cgi/content/short/2022.06.21.496937v1?rss=1" Bank, C. Schmitz, M. A. Morales-Arce, A. Y. 2022-06-25 doi:10.1101/2022.06.21.496937 Cold Spring Harbor Laboratory Press 2022-06-25 <![CDATA[ BioImage Model Zoo: A Community-Driven Resource for Accessible Deep Learning in BioImage Analysis ]]> https://biorxiv.org/cgi/content/short/2022.06.07.495102v1?rss=1" Ouyang, W. Beuttenmueller, F. Gomez-de-Mariscal, E. Pape, C. Burke, T. Garcia-Lopez-de-Haro, C. Russell, C. Moya-Sans, L. de-la-Torre-Gutierrez, C. Schmidt, D. Kutra, D. Novikov, M. Weigert, M. Schmidt, U. Bankhead, P. Jacquemet, G. Sage, D. Henriques, R. Munoz-Barrutia, A. Lundberg, E. Jug, F. Kreshuk, A. 2022-06-08 doi:10.1101/2022.06.07.495102 Cold Spring Harbor Laboratory Press 2022-06-08 <![CDATA[ Endoplasmic Reticulum membranes are continuously required to maintain mitotic spindle size and forces ]]> https://biorxiv.org/cgi/content/short/2022.05.14.491942v1?rss=1" Araujo, M. Tavares, A. Vieira, D. V. Telley, I. A. Oliveira, R. A. 2022-05-14 doi:10.1101/2022.05.14.491942 Cold Spring Harbor Laboratory Press 2022-05-14 <![CDATA[ RanBP1 plays an essential role in directed migration of neural crest cells during development. ]]> https://biorxiv.org/cgi/content/short/2022.05.05.490747v1?rss=1" Bariga, E. H. Alassadi, D. Mencarelli, C. Mayor, R. Pichaud, F. 2022-05-05 doi:10.1101/2022.05.05.490747 Cold Spring Harbor Laboratory Press 2022-05-05 <![CDATA[ The dual character of the inhibitory functions of CD6 ]]> https://biorxiv.org/cgi/content/short/2022.04.29.490054v1?rss=1" Santos, R. F. De Sousa Linhares, A. Cardoso, M. S. Novoa, A. Luche, H. Gartner, F. Malissen, B. Steinberger, P. Davis, S. Mallo, M. Oliveira, L. Carmo, A. M. 2022-05-01 doi:10.1101/2022.04.29.490054 Cold Spring Harbor Laboratory Press 2022-05-01 <![CDATA[ High-fidelity 3D live-cell nanoscopy through data-driven enhanced super-resolution radial fluctuation ]]> https://biorxiv.org/cgi/content/short/2022.04.07.487490v1?rss=1" Laine, R. F. Heil, H. S. Coelho, S. Nixon-Abell, J. Jimenez, A. Galgani, T. Stubb, A. Follain, G. Culley, S. Jacquemet, G. Hajj, B. Leterrier, C. Henriques, R. 2022-04-08 doi:10.1101/2022.04.07.487490 Cold Spring Harbor Laboratory Press 2022-04-08 <![CDATA[ Fluid manipulations uncover mechanosensation for zebrafish left-right establishment during one-hour time interval ]]> https://biorxiv.org/cgi/content/short/2022.04.21.489023v1?rss=1" Sampaio, P. Pestana, S. Guerrero, A. Telley, I. A. Smith, D. J. Lopes, S. S. 2022-04-22 doi:10.1101/2022.04.21.489023 Cold Spring Harbor Laboratory Press 2022-04-22 <![CDATA[ STING1 activation in brain endothelium by Plasmodium-sequestered heme leads to lethal cerebral malaria through activation of type I IFN response. ]]> https://biorxiv.org/cgi/content/short/2022.02.14.480268v1?rss=1" Pais, T. F. Ali, H. Silva, J. M. d. Duarte, N. Neres, R. Chhatbar, C. Acurcio, R. C. Guedes, R. C. Moraes, M. C. S. Costa-Silva, B. Ulrich, K. Penha-Goncalves, C. 2022-02-14 doi:10.1101/2022.02.14.480268 Cold Spring Harbor Laboratory Press 2022-02-14 <![CDATA[ The ADAM17 sheddase complex regulator iTAP modulates inflammation, epithelial repair, and tumor growth ]]> https://biorxiv.org/cgi/content/short/2022.04.11.487842v1?rss=1" Adrain, C. Badenes, M. Burbridge, E. Oikonomidi, I. Amin, A. de Carvalho, E. Kosack, L. Domingos, P. M. Faisca, P. 2022-04-12 doi:10.1101/2022.04.11.487842 Cold Spring Harbor Laboratory Press 2022-04-12 <![CDATA[ Ana1/CEP295 is an essential player in the centrosome maintenance program regulated by Polo kinase ]]> https://biorxiv.org/cgi/content/short/2022.04.06.487296v1?rss=1" Pimenta-Marques, A. R. Perestrelo, T. Reis-Rodrigues, P. Duarte, P. Lince-Faria, M. Bettencourt-Dias, M. 2022-04-06 doi:10.1101/2022.04.06.487296 Cold Spring Harbor Laboratory Press 2022-04-06 <![CDATA[ Xport-A functions as a chaperone by stabilizing the first 5 transmembrane domains of Rhodopsin-1 ]]> https://biorxiv.org/cgi/content/short/2022.04.01.486763v1?rss=1" Gaspar, C. J. Martins, J. C. Melo, M. N. Cordeiro, T. N. Adrain, C. Domingos, P. M. 2022-04-02 doi:10.1101/2022.04.01.486763 Cold Spring Harbor Laboratory Press 2022-04-02 <![CDATA[ The conserved transcriptional program of metazoan male germ cells uncovers ancient origins of human infertility ]]> https://biorxiv.org/cgi/content/short/2022.03.02.482557v1?rss=1" Correia, R. B. Almeida, J. M. Wyrwoll, M. J. Julca, I. Sobral, D. Misra, C. S. Guilgur, L. G. Schuppe, H.-C. Silva, N. Prudêncio, P. Nóvoa, A. Leocádio, A. S. Bom, J. Mallo, M. Kliesch, S. Mutwil, M. Rocha, L. M. Tüttelmann, F. Becker, J. D. Navarro-Costa, P. 2022-03-02 doi:10.1101/2022.03.02.482557 Cold Spring Harbor Laboratory Press 2022-03-02 <![CDATA[ ABA represses TOR and root meristem activity through nuclear exit of the SnRK1 kinase ]]> https://biorxiv.org/cgi/content/short/2021.12.27.474243v1?rss=1" Belda-Palazon, B. Costa, M. Beeckman, T. Rolland, F. Baena-Gonzalez, E. 2021-12-27 doi:10.1101/2021.12.27.474243 Cold Spring Harbor Laboratory Press 2021-12-27 <![CDATA[ CD5L constraints acute and systemic inflammation and can be a novel potent therapeutic agent against sepsis ]]> https://biorxiv.org/cgi/content/short/2022.03.08.483540v1?rss=1" Oliveira, L. Gomes, A. P. Santos, R. F. Cardoso, M. S. Novoa, A. Luche, H. Gärtner, F. Malissen, B. M. Mallo, M. Carmo, A. M. 2022-03-09 doi:10.1101/2022.03.08.483540 Cold Spring Harbor Laboratory Press 2022-03-09 <![CDATA[ Follicle cell contact maintains main body axis polarity in the Drosophila melanogaster oocyte ]]> https://biorxiv.org/cgi/content/short/2022.03.03.482911v1?rss=1" Milas, A. de-Carvalho, J. Telley, I. A. 2022-03-04 doi:10.1101/2022.03.03.482911 Cold Spring Harbor Laboratory Press 2022-03-04 <![CDATA[ Activation of the actin/MRTF-A/SRF signalling pathway in pre-malignant mammary epithelial cells by P-cadherin is essential for transformation ]]> https://biorxiv.org/cgi/content/short/2022.02.26.481995v1?rss=1" Faria, L. Canato, S. Jesus, T. T. Goncalves, M. Guerreiro, P. S. Lopes, C. S. Meireles, I. Morais-de-Sa, E. Paredes, J. Janody, F. 2022-02-27 doi:10.1101/2022.02.26.481995 Cold Spring Harbor Laboratory Press 2022-02-27 <![CDATA[ Vision-related convergent gene losses reveal SERPINE3's unknown role in the eye ]]> https://biorxiv.org/cgi/content/short/2022.02.25.481972v1?rss=1" Hiller, M. Indrischek, H. Hammer, J. Machate, A. Hecker, N. Kirilenko, B. Roscito, J. Hans, S. Norden, C. Brand, M. 2022-02-27 doi:10.1101/2022.02.25.481972 Cold Spring Harbor Laboratory Press 2022-02-27 <![CDATA[ Condensin II is required for efficient Spindle Assembly Checkpoint activation in Drosophila male meiosis ]]> https://biorxiv.org/cgi/content/short/2022.02.23.481572v1?rss=1" Horta, C. Tavares, A. Oliveira, R. A. 2022-02-24 doi:10.1101/2022.02.23.481572 Cold Spring Harbor Laboratory Press 2022-02-24 <![CDATA[ The metric backbone preserves community structure and is a primary transmission subgraph in contact networks ]]> https://biorxiv.org/cgi/content/short/2022.02.02.478784v1?rss=1" Brattig Correia, R. Barrat, A. Rocha, L. M. 2022-02-04 doi:10.1101/2022.02.02.478784 Cold Spring Harbor Laboratory Press 2022-02-04 <![CDATA[ ABA signaling prevents phosphodegradation of the Arabidopsis SR45 splicing factor to negatively autoregulate inhibition of early seedling development ]]> https://biorxiv.org/cgi/content/short/2022.02.03.479016v1?rss=1" Albuquerque-Martins, R. Szakonyi, D. Rowe, J. Jones, A. M. Duque, P. 2022-02-04 doi:10.1101/2022.02.03.479016 Cold Spring Harbor Laboratory Press 2022-02-04 <![CDATA[ The extinction time under mutational meltdown ]]> https://biorxiv.org/cgi/content/short/2022.02.01.478601v1?rss=1" Lansch-Justen, L. Cusseddu, D. Schmitz, M. A. Bank, C. 2022-02-02 doi:10.1101/2022.02.01.478601 Cold Spring Harbor Laboratory Press 2022-02-02 <![CDATA[ Nanoscale colocalization of NK cell activating and inhibitory receptors controls signal integration ]]> https://biorxiv.org/cgi/content/short/266429v1?rss=1" Tomaz, D. Pereira, P. M. Guerra, N. Dyson, J. Henriques, R. Gould, K. 2018-02-15 doi:10.1101/266429 Cold Spring Harbor Laboratory Press 2018-02-15 <![CDATA[ Matrix topology guides collective cell migration in vivo ]]> https://biorxiv.org/cgi/content/short/2022.01.31.478442v1?rss=1" Soans, K. G. Ramos, A. P. Sidhaye, J. Krishna, A. Solomatina, A. Hoffmann, K. B. Schluessler, R. Guck, J. Sbalzarini, I. F. Modes, C. D. Norden, C. 2022-01-31 doi:10.1101/2022.01.31.478442 Cold Spring Harbor Laboratory Press 2022-01-31 <![CDATA[ Assessing Myf5 and Lbx1 contribution to carapace development by reproducing their turtle-specific signatures in mouse embryos ]]> https://biorxiv.org/cgi/content/short/2022.01.18.476730v1?rss=1" Tekko, T. Novoa, A. Mallo, M. 2022-01-18 doi:10.1101/2022.01.18.476730 Cold Spring Harbor Laboratory Press 2022-01-18 <![CDATA[ Thermodynamic analysis of Zα domain-nucleic acid interactions ]]> https://biorxiv.org/cgi/content/short/2022.01.17.476573v1?rss=1" SRINIVASAN, B. Kus, K. Athanasiadis, A. 2022-01-17 doi:10.1101/2022.01.17.476573 Cold Spring Harbor Laboratory Press 2022-01-17 <![CDATA[ Two modes of evolution shape bacterial strain diversity in the gut for thousands of generations ]]> https://biorxiv.org/cgi/content/short/2022.01.11.475860v1?rss=1" Frazao, N. Konrad, A. Güleresi, D. Lässig, M. Gordo, I. 2022-01-12 doi:10.1101/2022.01.11.475860 Cold Spring Harbor Laboratory Press 2022-01-12 <![CDATA[ A Protective Inter-Organ Communication Response Against Life-Threatening Malarial Anemia ]]> https://biorxiv.org/cgi/content/short/2022.01.12.475857v1?rss=1" Wu, Q. Sacomboio, E. Souza, L. V. Martins, R. Cardoso, S. Ademolue, T. W. Paixao, T. Lehtimaki, J. Norden, C. Tharaux, P.-L. Weiss, G. Wang, F. Ramos, S. Soares, M. P. 2022-01-12 doi:10.1101/2022.01.12.475857 Cold Spring Harbor Laboratory Press 2022-01-12 <![CDATA[ Gut melange a trois: fluctuating selection modulated by microbiota, host immune system, and antibiotics ]]> https://biorxiv.org/cgi/content/short/2021.12.30.474527v1?rss=1" Barreto, H. C. Abreu, B. Gordo, I. 2021-12-30 doi:10.1101/2021.12.30.474527 Cold Spring Harbor Laboratory Press 2021-12-30 <![CDATA[ The rotational diffusion of B-cell receptor vs antibody paratopes differentially affects their antigen binding kinetics ]]> https://biorxiv.org/cgi/content/short/2022.07.19.500451v1?rss=1" Garcia-Sanchez, M. Faro, J. Castro, M. 2022-07-20 doi:10.1101/2022.07.19.500451 Cold Spring Harbor Laboratory Press 2022-07-20 <![CDATA[ Effects of Wolbachia on transposable element activity largely depend on Drosophila melanogaster host genotype ]]> https://biorxiv.org/cgi/content/short/2022.07.21.500779v1?rss=1" Eugenio, A. T. Marialva, M. S. P. Beldade, P. 2022-07-22 doi:10.1101/2022.07.21.500779 Cold Spring Harbor Laboratory Press 2022-07-22 <![CDATA[ Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue ]]> https://biorxiv.org/cgi/content/short/2022.07.28.501817v1?rss=1" Kumar, S. Basto, A. Ribeiro, F. Almeida, S. S. C. P. Campos, P. Peres, C. Al-Khalidi, S. Kilbey, A. Tosello, J. Piaggio, E. Russo, M. Gama-Carvalho, M. Coffelt, S. B. Roberts, E. W. Florindo, H. Graca, L. 2022-07-31 doi:10.1101/2022.07.28.501817 Cold Spring Harbor Laboratory Press 2022-07-31 <![CDATA[ Influenza A virus liquid condensates can undergo pharmacological hardening ]]> https://biorxiv.org/cgi/content/short/2022.08.03.502602v1?rss=1" Etibor, T. A. Sridharan, S. Vale-Costa, S. Bras, D. Becher, I. Vello, V. Ferreira, F. Alenquer, M. Savitski, M. M. Amorim, M. J. 2022-08-05 doi:10.1101/2022.08.03.502602 Cold Spring Harbor Laboratory Press 2022-08-05 <![CDATA[ Deterministic and probabilistic fate decisions co-exist in a single retinal lineage ]]> https://biorxiv.org/cgi/content/short/2022.08.11.503564v1?rss=1" Nerli, E. Kretzschmar, J. Bianucci, T. Rocha-Martins, M. Zechner, C. Norden, C. 2022-08-11 doi:10.1101/2022.08.11.503564 Cold Spring Harbor Laboratory Press 2022-08-11 <![CDATA[ Fast4DReg: Fast registration of 4D microscopy datasets ]]> https://biorxiv.org/cgi/content/short/2022.08.22.504744v1?rss=1" Pylvänäinen, J. Laine, R. Ghimire, S. Follain, G. Henriques, R. Jacquemet, G. 2022-08-23 doi:10.1101/2022.08.22.504744 Cold Spring Harbor Laboratory Press 2022-08-23 <![CDATA[ Epistasis decreases with increasing antibiotic pressure but not temperature ]]> https://biorxiv.org/cgi/content/short/2022.09.01.506172v1?rss=1" Ghenu, A.-H. Amado, A. Gordo, I. Bank, C. 2022-09-03 doi:10.1101/2022.09.01.506172 Cold Spring Harbor Laboratory Press 2022-09-03 <![CDATA[ STAT1 is required to establish but not maintain IFNγ-induced transcriptional memory ]]> https://biorxiv.org/cgi/content/short/2022.09.17.508285v1?rss=1" Tehrani, S. S. Mikulski, P. Abdul-Zani, I. Mata, J. F. Siwek, W. Jansen, L. E. T. 2022-09-17 doi:10.1101/2022.09.17.508285 Cold Spring Harbor Laboratory Press 2022-09-17 <![CDATA[ McIdas localizes at centrioles and controls centriole numbers through PLK4-dependent phosphorylation ]]> https://biorxiv.org/cgi/content/short/2022.09.30.510086v1?rss=1" Arbi, M. Skamnelou, M. Bournaka, S. Zitouni, S. Tsaridou, S. Karayel, O. Vasilopoulou, C. G. Tsika, A. C. Giakoumakis, N. N. Spyroulias, G. A. Mann, M. Bettencourt-Dias, M. Taraviras, S. Lygerou, Z. 2022-10-01 doi:10.1101/2022.09.30.510086 Cold Spring Harbor Laboratory Press 2022-10-01 <![CDATA[ Semaphorin 4B is an ADAM17-cleaved inhibitor of adipocyte thermogenesis ]]> https://biorxiv.org/cgi/content/short/2022.10.11.511765v1?rss=1" Amin, A. Badenes, M. Tueshaus, J. de Carvalho, E. Burbridge, E. Faisca, P. Travnickova, K. Barros, A. Carobbio, S. Domingos, P. Vidal-Puig, A. Moita, L. F. Maguire, S. Strisovsky, K. Lichtenthaler, S. F. Adrain, C. 2022-10-13 doi:10.1101/2022.10.11.511765 Cold Spring Harbor Laboratory Press 2022-10-13 <![CDATA[ How ancient forest fragmentation and riparian connectivity generate high levels of genetic diversity in a micro-endemic Malagasy tree ]]> https://biorxiv.org/cgi/content/short/2020.11.25.394544v1?rss=1" Salmona, J. Dresen, A. Ranaivoson, A. E. Manzi, S. Le Pors, B. Hong-Wa, C. Razanatsoa, J. Andriaholinirina, N. V. Rasoloharijaona, S. Vavitsara, M.-E. Besnard, G. 2020-11-26 doi:10.1101/2020.11.25.394544 Cold Spring Harbor Laboratory Press 2020-11-26 <![CDATA[ On the genetic consequences of habitat contraction: edge effects and habitat loss ]]> https://biorxiv.org/cgi/content/short/2022.10.25.513679v1?rss=1" Sgarlata, G. M. Maie, T. de Zoeten, T. Rasteiro, R. Chikhi, L. 2022-10-26 doi:10.1101/2022.10.25.513679 Cold Spring Harbor Laboratory Press 2022-10-26 <![CDATA[ Metabolic and demographic evolution in response to interspecific competition ]]> https://biorxiv.org/cgi/content/short/2022.10.19.512836v1?rss=1" Ghedini, G. Marshall, D. 2022-10-21 doi:10.1101/2022.10.19.512836 Cold Spring Harbor Laboratory Press 2022-10-21 <![CDATA[ The Genomic Diversity of the Eliurus genus in northern Madagascar with a Putative New Species ]]> https://biorxiv.org/cgi/content/short/2022.10.21.513246v1?rss=1" Sgarlata, G. M. Rasolondraibe, E. Salmona, J. Le Pors, B. Ralantoharijaona, T. Rakotonanahary, A. Jan, F. Manzi, S. Iribar-Pelozuelo, A. Zaonarivelo, J. R. Andriaholinirina, N. V. Rasoloharijaona, S. Chikhi, L. 2022-10-24 doi:10.1101/2022.10.21.513246 Cold Spring Harbor Laboratory Press 2022-10-24 <![CDATA[ An SNF2 helicase-like protein links mitotic transcription termination to sister chromatid resolution ]]> https://biorxiv.org/cgi/content/short/2022.11.21.517340v1?rss=1" Carmo, C. Coelho, J. Silva, R. Tavares, A. Boavida, A. Gaetani, P. Martinho, R. G. Oliveira, R. A. 2022-11-22 doi:10.1101/2022.11.21.517340 Cold Spring Harbor Laboratory Press 2022-11-22 <![CDATA[ Brain Endothelial Cells Exposure to Malaria Parasites Links Type I Interferon Signalling to Antigen Presentation, Immunoproteasome Activation, Endothelium Disruption, and Cellular Metabolism ]]> https://biorxiv.org/cgi/content/short/2022.11.26.518027v1?rss=1" View larger version (22K): org.highwire.dtl.DTLVardef@859960org.highwire.dtl.DTLVardef@1186de4org.highwire.dtl.DTLVardef@d6b625org.highwire.dtl.DTLVardef@50751d_HPS_FORMAT_FIGEXP M_FIG C_FIG AUTHOR SUMMARYCerebral malaria is a severe clinical form of malaria infection that leads to respiratory arrest and death due to brain swelling. Disruption of blood vessels in the brain barrier is a hallmark of cerebral malaria development. However, the underlying pathological mechanisms are still unsettled. We explored the hypothesis that immune response of brain blood vessels to malaria infection is an initiator of inflammatory events leading to cerebral malaria. Our experiments unveiled that proinflammatory Type I interferon action increases the presentation of parasite molecules by brain blood vessel cells to cytotoxic immune cells and promotes brain vessel disruption. We found that these effects are determined by activation of protein degradation systems upon exposure of brain blood vessel cells to malaria parasite-infected erythrocytes. Our findings unveil a critical role of Type I interferon in brain blood vessels cells signaling in initiating immunopathology mechanisms associated to cerebral malaria development and suggest that blocking Type I interferon induction in the brain provides a path to prevent this disease. ]]> Muktadir Shafi, A. M. Vegvari, A. Zubarev, R. Penha-Goncalves, C. 2022-11-26 doi:10.1101/2022.11.26.518027 Cold Spring Harbor Laboratory Press 2022-11-26 <![CDATA[ Novel pathways converge with quorum sensing to regulate plant and insect host-specific factors in Erwinia carotovora ]]> https://biorxiv.org/cgi/content/short/2023.03.13.532345v1?rss=1" Vieira, F. J. D. Teixeira, L. Xavier, K. B. 2023-03-13 doi:10.1101/2023.03.13.532345 Cold Spring Harbor Laboratory Press 2023-03-13 <![CDATA[ Questioning Neanderthal admixture: on models, robustness and consensus in human evolution ]]> https://biorxiv.org/cgi/content/short/2023.04.05.535686v1?rss=1" Tournebize, R. Chikhi, L. 2023-04-05 doi:10.1101/2023.04.05.535686 Cold Spring Harbor Laboratory Press 2023-04-05 <![CDATA[ The positioning mechanics of microtubule asters in Drosophila embryo explants ]]> https://biorxiv.org/cgi/content/short/2023.03.31.535028v1?rss=1" de-Carvalho, J. Tlili, S. L. Saunders, T. E. Telley, I. A. 2023-04-01 doi:10.1101/2023.03.31.535028 Cold Spring Harbor Laboratory Press 2023-04-01 <![CDATA[ Transcriptional profiling of populations in the clam Ruditapes decussatus suggests genetically determined differentiation in gene-expression along parallel temperature gradients and between races of the Atlantic Ocean and West Mediterranean sea ]]> https://biorxiv.org/cgi/content/short/2023.03.28.533615v1?rss=1" Saavedra, C. Milan, M. Leite, R. B. Cordero, D. Patarnello, T. Cancela, L. Bargelloni, L. 2023-03-29 doi:10.1101/2023.03.28.533615 Cold Spring Harbor Laboratory Press 2023-03-29 <![CDATA[ Shared evolutionary path in social microbiomes ]]> https://biorxiv.org/cgi/content/short/2023.02.07.527449v1?rss=1" Frazao, N. Gordo, I. 2023-02-07 doi:10.1101/2023.02.07.527449 Cold Spring Harbor Laboratory Press 2023-02-07 <![CDATA[ Evolutionary conservation of mechanical strain distributions in functional transitions of protein structures ]]> https://biorxiv.org/cgi/content/short/2023.02.07.527482v1?rss=1" Sartori, P. Leibler, S. 2023-02-07 doi:10.1101/2023.02.07.527482 Cold Spring Harbor Laboratory Press 2023-02-07 <![CDATA[ HOS1 promotes plant tolerance to low-energy stress via the SnRK1 protein kinase ]]> https://biorxiv.org/cgi/content/short/2023.01.26.525711v1?rss=1" Margalha, L. Elias, A. Belda-Palazon, B. Peixoto, B. Confraria, A. Baena-Gonzalez, E. 2023-01-26 doi:10.1101/2023.01.26.525711 Cold Spring Harbor Laboratory Press 2023-01-26 <![CDATA[ Idioblasts accumulating anticancer alkaloids in Catharanthus roseus leaves are a unique cell type ]]> https://biorxiv.org/cgi/content/short/2023.02.24.529939v1?rss=1" Guedes, J. G. Ribeiro, R. Carqueijeiro, I. Guimaraes, A. L. Bispo, C. Archer, J. Azevedo, H. Fonseca, N. A. Sottomayor, M. 2023-02-27 doi:10.1101/2023.02.24.529939 Cold Spring Harbor Laboratory Press 2023-02-27 <![CDATA[ Pot1 promotes telomere DNA replication via the Stn1-Ten1 complex in fission yeast ]]> https://biorxiv.org/cgi/content/short/2023.01.23.525167v1?rss=1" Borges, P. C. Escandell, J. M. Matmati, S. Coulon, S. Ferreira, M. G. 2023-01-23 doi:10.1101/2023.01.23.525167 Cold Spring Harbor Laboratory Press 2023-01-23 <![CDATA[ Sugar signaling modulates SHOOT MERISTEMLESS expression and meristem function in Arabidopsis ]]> https://biorxiv.org/cgi/content/short/2023.01.08.522175v1?rss=1" Lopes, F. L. Formosa-Jordan, P. Malivert, A. Margalha, L. Confraria, A. Feil, R. Lunn, J. E. Jönsson, H. Landrein, B. Baena-Gonzalez, E. 2023-01-08 doi:10.1101/2023.01.08.522175 Cold Spring Harbor Laboratory Press 2023-01-08 <![CDATA[ ATG9A facilitates the biogenesis of influenza A virus liquid condensates near the ER by dissociating recycling vesicles from microtubules ]]> https://biorxiv.org/cgi/content/short/2022.12.21.521536v1?rss=1" Vale-Costa, S. Etibor, T. A. Bras, D. Sousa, A. L. Amorim, M. J. 2022-12-22 doi:10.1101/2022.12.21.521536 Cold Spring Harbor Laboratory Press 2022-12-22 <![CDATA[ Regulatory changes associated with the head to trunk developmental transition ]]> https://biorxiv.org/cgi/content/short/2022.12.18.520961v1?rss=1" Duarte, P. Brattig Correia, R. Novoa, A. Mallo, M. 2022-12-19 doi:10.1101/2022.12.18.520961 Cold Spring Harbor Laboratory Press 2022-12-19 <![CDATA[ Pulse-chase experiments reveal dynamics of RNA binding protein Exuperantia in Drosophila melanogaster egg chambers ]]> https://biorxiv.org/cgi/content/short/2022.12.06.519343v1?rss=1" Vieira, D. V. Carlota, R. R. de-Carvalho, J. Telley, I. A. 2022-12-06 doi:10.1101/2022.12.06.519343 Cold Spring Harbor Laboratory Press 2022-12-06 <![CDATA[ Microbes are potential key players in the evolution of life histories and aging in Caenorhabditis elegans ]]> https://biorxiv.org/cgi/content/short/2022.02.26.482130v1?rss=1" Santos, J. Matos, M. Flatt, T. Chelo, I. M. 2022-02-27 doi:10.1101/2022.02.26.482130 Cold Spring Harbor Laboratory Press 2022-02-27 <![CDATA[ Mapping host-microbe transcriptional interactions by dual perturb-seq ]]> https://biorxiv.org/cgi/content/short/2023.04.21.537779v1?rss=1" Butterworth, S. Kordova, K. Chandrasekaran, S. Thomas, K. K. Torelli, F. Lockyer, E. J. Edwards, A. Goldstone, R. Koshy, A. A. Treeck, M. 2023-04-21 doi:10.1101/2023.04.21.537779 Cold Spring Harbor Laboratory Press 2023-04-21 <![CDATA[ A novel virus-induced cyclic dinucleotide, 2'3'-c-di-GMP, mediates STING-dependent antiviral immunity in Drosophila ]]> https://biorxiv.org/cgi/content/short/2023.05.08.539652v1?rss=1" Cai, H. Li, L. Slavik, K. Huang, J. Yin, T. Hedelin, L. Xiang, Z. Yang, Y. Li, X. Chen, Y. Wei, Z. Deng, H. Chen, D. Jiao, R. Martins, N. Meignin, C. Kranzusch, P. J. Imler, J.-L. 2023-05-09 doi:10.1101/2023.05.08.539652 Cold Spring Harbor Laboratory Press 2023-05-09 <![CDATA[ Immunomodulatory Leptin Receptor+ Sympathetic Perineurial Cells Protect Against Obesity by Facilitating Neuroendocrine-Mediated Brown Adipose Tissue Thermogenesis ]]> https://biorxiv.org/cgi/content/short/2023.05.09.539963v1?rss=1" View larger version (30K): org.highwire.dtl.DTLVardef@195fa69org.highwire.dtl.DTLVardef@16b2e5eorg.highwire.dtl.DTLVardef@1b12b62org.highwire.dtl.DTLVardef@973c1b_HPS_FORMAT_FIGEXP M_FIG C_FIG Highlights- Sympathetic Perineurial Cells (SPCs) co-express LepR+ and IL33 - SPC-derived IL33 prevents BAT inflammation via Treg and eosinophil recruitment - Obesity is worsened in high fat diet-fed SPCIL33cKO mice, despite normal food intake - Adaptive thermogenesis is impaired in SPCIL33cKO mice - Rescue of metabolic adaptation to fasting by leptin is impaired in SPCIL33cKO mice - SPCs link leptin to immunometabolic regulation of body weight homeostasis ]]> Haberman, E. R. Sarker, G. Arus, B. A. Yilmaz-Ozcan, S. Martinez-Sanchez, N. Freibergerova, E. Fernandez-Gonzalez, I. Zentai, C. O'Brien, C. J. O. Grainger, D. E. Chakarov, S. Raimondi, A. Iannacone, M. Lopez, M. Ginhoux, F. Domingos, A. I. 2023-05-10 doi:10.1101/2023.05.09.539963 Cold Spring Harbor Laboratory Press 2023-05-10 <![CDATA[ CLEM-Reg: An automated point cloud based registration algorithm for correlative light and volume electron microscopy ]]> https://biorxiv.org/cgi/content/short/2023.05.11.540445v1?rss=1" Krentzel, D. Elphick, M. Domart, M.-C. Peddie, C. J. Laine, R. F. Henriques, R. Collinson, L. M. Jones, M. L. 2023-05-12 doi:10.1101/2023.05.11.540445 Cold Spring Harbor Laboratory Press 2023-05-12 <![CDATA[ The maintenance of centriole appendages and motile cilia basal body anchoring relies on TBCCD1 ]]> https://biorxiv.org/cgi/content/short/2023.07.26.549647v1?rss=1" Carmona, B. Camelo, C. Mehraz, M. Lemullois, M. Lince-Faria, M. Coyaud, E. Marinho, H. S. Goncalves, J. Nolasco, S. Pinto, F. Raught, B. Tassin, A.-M. Koll, F. Soares, H. 2023-07-26 doi:10.1101/2023.07.26.549647 Cold Spring Harbor Laboratory Press 2023-07-26 <![CDATA[ The substrate quality of CK2 target sites has a determinant role on their function and evolution ]]> https://biorxiv.org/cgi/content/short/2023.07.03.547533v1?rss=1" Bradley, D. Garand, C. Belda, H. Gagnon-Arsenault, I. Treeck, M. Elowe, S. Landry, C. 2023-07-03 doi:10.1101/2023.07.03.547533 Cold Spring Harbor Laboratory Press 2023-07-03 <![CDATA[ Tgfbr1 controls developmental plasticity between the hindlimb and external genitalia by remodeling their regulatory landscape ]]> https://biorxiv.org/cgi/content/short/2023.07.07.548120v1?rss=1" Lozovska, A. Korovesi, A. G. Dias, A. Lopes, A. Fowler, D. A. Martins, G. G. Novoa, A. Mallo, M. 2023-07-07 doi:10.1101/2023.07.07.548120 Cold Spring Harbor Laboratory Press 2023-07-07 <![CDATA[ Robustness of biomolecular networks suggests functional modules far from the edge of chaos ]]> https://biorxiv.org/cgi/content/short/2023.06.30.547297v1?rss=1" Park, K. H. Costa, F. X. Rocha, L. M. Albert, R. Rozum, J. C. 2023-07-02 doi:10.1101/2023.06.30.547297 Cold Spring Harbor Laboratory Press 2023-07-02 <![CDATA[ Processive movement of Staphylococcus aureus essential septal peptidoglycan synthases is independent of FtsZ treadmilling and drives cell constriction ]]> https://biorxiv.org/cgi/content/short/2023.06.29.547026v1?rss=1" Schaeper, S. Brito, A. D. Saraiva, B. M. Squyres, G. R. Holmes, M. J. Garner, E. C. Hensel, Z. Henriques, R. Pinho, M. G. 2023-06-29 doi:10.1101/2023.06.29.547026 Cold Spring Harbor Laboratory Press 2023-06-29 <![CDATA[ In search of the Goldilocks zone for hybrid speciation II: hard times for hybrid speciation. ]]> https://biorxiv.org/cgi/content/short/2023.02.15.528680v1?rss=1" Blanckaert, A. Sriram, V. Bank, C. 2023-02-15 doi:10.1101/2023.02.15.528680 Cold Spring Harbor Laboratory Press 2023-02-15 <![CDATA[ Theft of Host Transferrin Receptor-1 by Toxoplasma gondii is required for infection ]]> https://biorxiv.org/cgi/content/short/2023.06.23.546322v1?rss=1" Denton, S. L. Mejia, A. Nevarez, L. L. Soares, M. P. Fox, B. A. Bzik, D. J. Gigley, J. P. 2023-06-24 doi:10.1101/2023.06.23.546322 Cold Spring Harbor Laboratory Press 2023-06-24 <![CDATA[ Genetic basis of variation in thermal developmental plasticity for Drosophila melanogaster body pigmentation ]]> https://biorxiv.org/cgi/content/short/2023.09.03.556093v1?rss=1" Lafuente, E. Duneau, D. F. Beldade, P. 2023-09-03 doi:10.1101/2023.09.03.556093 Cold Spring Harbor Laboratory Press 2023-09-03 <![CDATA[ Tgfbr1 regulates lateral plate mesoderm and endoderm reorganization during the trunk to tail transition ]]> https://biorxiv.org/cgi/content/short/2023.08.22.554351v1?rss=1" Lozovska, A. Nóvoa, A. Kuo, Y.-Y. Jurberg, A. D. Martins, G. G. Hadjantonakis, A.-K. Mallo, M. 2023-08-23 doi:10.1101/2023.08.22.554351 Cold Spring Harbor Laboratory Press 2023-08-23 <![CDATA[ Adaptation to oral infection in D. melanogaster through evolution of both resistance and disease tolerance mechanisms ]]> https://biorxiv.org/cgi/content/short/2023.08.23.554397v1?rss=1" Paulo, T. F. Akyaw, P. A. Paixao, T. Sucena, E. 2023-08-24 doi:10.1101/2023.08.23.554397 Cold Spring Harbor Laboratory Press 2023-08-24 <![CDATA[ African bush pigs exhibit porous species boundaries and appeared in Madagascar concurrently with human arrival ]]> https://biorxiv.org/cgi/content/short/2023.08.23.553838v1?rss=1" Balboa, R. F. Bertola, L. D. Bruniche-Olsen, A. Rasmussen, M. S. Liu, X. Besnard, G. Salmona, J. Santander, C. G. He, S. Zinner, D. Pedrono, M. Muwanika, V. Masembe, C. Schubert, M. Kuja, J. Quinn, L. Garcia-Erill, G. Rakotoarivony, R. Henrique, M. Lin, L. Wang, X. Heaton, M. P. Smith, T. P. L. Hanghoj, K. Sinding, M.-H. S. Atickem, A. Chikhi, L. Roos, C. Gaubert, P. Siegismund, H. R. Moltke, I. Albrechtsen, A. Heller, R. 2023-08-24 doi:10.1101/2023.08.23.553838 Cold Spring Harbor Laboratory Press 2023-08-24 <![CDATA[ NanoPyx: super-fast bioimage analysis powered by adaptive machine learning ]]> https://biorxiv.org/cgi/content/short/2023.08.13.553080v1?rss=1" Saraiva, B. M. Cunha, I. M. Brito, A. D. Follain, G. Portela, R. Haase, R. Pereira, P. M. Jacquemet, G. Henriques, R. 2023-08-14 doi:10.1101/2023.08.13.553080 Cold Spring Harbor Laboratory Press 2023-08-14 <![CDATA[ Novel gut probiotic engages microbiota for recovery and pathobiont clearance while preventing inflammation ]]> https://biorxiv.org/cgi/content/short/2023.11.14.566997v1?rss=1" Cabral, V. Oliveira, R. A. Correia, M. B. Pedro, M. F. Ubeda, C. Xavier, K. B. 2023-11-15 doi:10.1101/2023.11.14.566997 Cold Spring Harbor Laboratory Press 2023-11-15 <![CDATA[ Fending for oneself or partnering up: Competition between mixo- and heterotrophic ciliates under dynamic resource supply ]]> https://biorxiv.org/cgi/content/short/2023.11.06.564392v1?rss=1" Flöder, S. Klauschies, T. Klaassen, M. Stoffers, T. Lambrecht, M. Moorthi, S. 2023-11-06 doi:10.1101/2023.11.06.564392 Cold Spring Harbor Laboratory Press 2023-11-06 <![CDATA[ Pervasive relaxed selection on spermatogenesis genes coincident with the evolution of polygyny in gorillas ]]> https://biorxiv.org/cgi/content/short/2023.10.27.564379v1?rss=1" Bowman, J. D. Silva, N. Schüueftan, E. Almeida, J. M. Brattig-Correia, R. Oliveira, R. A. Tüttelmann, F. J. Enard, D. Navarro-Costa, P. Lynch, V. J. 2023-10-27 doi:10.1101/2023.10.27.564379 Cold Spring Harbor Laboratory Press 2023-10-27 <![CDATA[ Unpredictability of the fitness effects of antimicrobial resistance mutations across environments in Escherichia coli ]]> https://biorxiv.org/cgi/content/short/2023.10.25.563906v1?rss=1" Hinz, A. Amado, A. Kassen, R. Bank, C. Wong, A. 2023-10-27 doi:10.1101/2023.10.25.563906 Cold Spring Harbor Laboratory Press 2023-10-27 <![CDATA[ Transertion and cell geometry organize the Escherichia coli nucleoid during rapid growth ]]> https://biorxiv.org/cgi/content/short/2023.10.16.562172v1?rss=1" Spahn, C. Middlemiss, S. Gomez-de-Mariscal, E. Henriques, R. Bode, H. B. Holden, S. Heilemann, M. 2023-10-16 doi:10.1101/2023.10.16.562172 Cold Spring Harbor Laboratory Press 2023-10-16 <![CDATA[ Investigation of Trypanosoma-induced vascular damage sheds insights into Trypanosoma vivax sequestration ]]> https://biorxiv.org/cgi/content/short/2023.09.18.558284v1?rss=1" Pereira, S. S. Bras, D. Porqueddu, T. Nascimento, A. M. De Niz, M. 2023-09-18 doi:10.1101/2023.09.18.558284 Cold Spring Harbor Laboratory Press 2023-09-18 <![CDATA[ Influenza A virus activates the unfolded protein response and induces the accumulation of insoluble protein aggregates that are essential for efficient viral propagation ]]> https://biorxiv.org/cgi/content/short/2023.09.11.557148v1?rss=1" Marques, M. Ramos, B. Albuquerque, H. Pereira, M. Ribeiro, D. R. Nunes, A. Sarabando, J. Bras, D. Ferreira, A. R. Vitorino, R. Amorim, M. J. Silva, A. Soares, A. R. Ribeiro, D. 2023-09-11 doi:10.1101/2023.09.11.557148 Cold Spring Harbor Laboratory Press 2023-09-11 <![CDATA[ DL4MicEverywhere: Deep learning for microscopy made flexible, shareable, and reproducible ]]> https://biorxiv.org/cgi/content/short/2023.11.19.567606v1?rss=1" Hidalgo-Cenalmor, I. Pylvänäinen, J. W. Ferreira, M. G. Russell, C. T. Arganda-Carreras, I. AI4Life Consortium, Jacquemet, G. Henriques, R. Gomez-de-Mariscal, E. 2023-11-19 doi:10.1101/2023.11.19.567606 Cold Spring Harbor Laboratory Press 2023-11-19 <![CDATA[ Expression of the MSPDBL2 antigen in a discrete subset of Plasmodium falciparum schizonts is regulated by GDV1 but not linked to sexual commitment ]]> https://biorxiv.org/cgi/content/short/2023.11.21.568010v1?rss=1" Freville, A. Stewart, L. B. Tetteh, K. K. Treeck, M. Cortes, A. Voss, T. S. Tarr, S. J. Baker, D. A. Conway, D. 2023-11-21 doi:10.1101/2023.11.21.568010 Cold Spring Harbor Laboratory Press 2023-11-21 <![CDATA[ Fracture in Living Cell Monolayers ]]> https://biorxiv.org/cgi/content/short/2023.01.05.522736v1?rss=1" Duque, J. Bonfanti, A. Fouchard, J. Ferber, E. Harris, A. Kabla, A. Charras, G. 2023-01-06 doi:10.1101/2023.01.05.522736 Cold Spring Harbor Laboratory Press 2023-01-06 <![CDATA[ An Arabidopsis SR protein relieving ABA inhibition of seedling establishment represses ABA-responsive alternative splicing ]]> https://biorxiv.org/cgi/content/short/2023.12.19.572415v1?rss=1" Laloum, T. Martin, G. Lewinski, M. Yanez, R. J. R. Koester, T. Staiger, D. Duque, P. 2023-12-21 doi:10.1101/2023.12.19.572415 Cold Spring Harbor Laboratory Press 2023-12-21 <![CDATA[ Comparative genomic analysis reveals novel phylogenetically intermediate Streptococci with high phenotypic diversity in the human distal lung microbiota. ]]> https://biorxiv.org/cgi/content/short/2023.12.22.572891v1?rss=1" Kanungo, S. Bonilla-Rosso, G. Sarton-Loheac, G. Küffer, M. Hilty, M. Geiser, T. Engel, P. Das, S. 2023-12-23 doi:10.1101/2023.12.22.572891 Cold Spring Harbor Laboratory Press 2023-12-23 <![CDATA[ BiaPy: A unified framework for versatile bioimage analysis with deep learning ]]> https://biorxiv.org/cgi/content/short/2024.02.03.576026v1?rss=1" Franco-Barranco, D. Andres-San Roman, J. A. Hidalgo-Cenalmor, I. Backova, L. Gonzalez-Marfil, A. Caporal, C. Chessel, A. Gomez-Galvez, P. Escudero, L. M. Wei, D. Munoz-Barrutia, A. Arganda-Carreras, I. 2024-02-05 doi:10.1101/2024.02.03.576026 Cold Spring Harbor Laboratory Press 2024-02-05 <![CDATA[ Adaptation of human cell populations to different levels of centriole amplification involves a two-step response ]]> https://biorxiv.org/cgi/content/short/2024.02.15.580424v1?rss=1" Dias Louro, M. A. Peneda, C. Bank, C. Bettencourt Dias, M. 2024-02-16 doi:10.1101/2024.02.15.580424 Cold Spring Harbor Laboratory Press 2024-02-16 <![CDATA[ cGAS-STING is responsible for aging of telomerase deficient zebrafish. ]]> https://biorxiv.org/cgi/content/short/2024.03.11.584360v1?rss=1" Serifoglu, N. Allavena, G. Bastos-Lopes, B. Marzullo, M. Bousounis, P. Trompouki, E. Ferreira, M. G. 2024-03-12 doi:10.1101/2024.03.11.584360 Cold Spring Harbor Laboratory Press 2024-03-12 <![CDATA[ Thermodynamic dissipation constrains metabolic versatility of unicellular growth ]]> https://biorxiv.org/cgi/content/short/2024.03.21.585772v1?rss=1" Cossetto, T. Rodenfels, J. Sartori, P. 2024-03-26 doi:10.1101/2024.03.21.585772 Cold Spring Harbor Laboratory Press 2024-03-26 <![CDATA[ A chromosome-level genome assembly of the Hispid cotton rat (Sigmodon hispidus), a model for human pathogenic virus infections ]]> https://biorxiv.org/cgi/content/short/2024.03.21.586163v1?rss=1" Lilue, J. Corvelo, A. Gomez-Garrido, J. Yang, F. Akagi, K. Green, G. Ng, B. L. Fu, B. Chorostecki, U. Warner, S. C. Marcet-Houben, M. Keane, T. Mullikin, J. C. Alioto, T. Gabaldon, T. Hubert, B. Symer, D. E. Niewiesk, S. 2024-03-26 doi:10.1101/2024.03.21.586163 Cold Spring Harbor Laboratory Press 2024-03-26 <![CDATA[ Biomass competition unifies individual and community scaling patterns ]]> https://biorxiv.org/cgi/content/short/2024.03.25.586593v1?rss=1" Fant, L. Ghedini, G. 2024-03-29 doi:10.1101/2024.03.25.586593 Cold Spring Harbor Laboratory Press 2024-03-29 <![CDATA[ Life history traits influence the dynamics of genetic diversityin a refugium population undergoing expansion andcontraction ]]> https://biorxiv.org/cgi/content/short/2024.03.28.586951v1?rss=1" Vishwakarma, R. Sgarlata, G. M. Soriano-Panos, D. Rasteiro, R. Maie, T. Paixao, T. Tournebize, R. Chikhi, L. 2024-03-31 doi:10.1101/2024.03.28.586951 Cold Spring Harbor Laboratory Press 2024-03-31 <![CDATA[ Nuclear deformability facilitates apical nuclear migration in the developing zebrafish retina ]]> https://biorxiv.org/cgi/content/short/2024.04.04.588091v1?rss=1" Maia-Gil, M. Gorjao, M. Belousov, R. Espina, J. A. Coelho, J. Ramos, A. P. Barriga, E. H. Erzberger, A. Norden, C. 2024-04-04 doi:10.1101/2024.04.04.588091 Cold Spring Harbor Laboratory Press 2024-04-04 <![CDATA[ IFI207, a young and fast-evolving protein, controls retroviral replication via the STING pathway ]]> https://biorxiv.org/cgi/content/short/2024.04.30.591891v1?rss=1" Moran, E. A. Salas-Briceno, K. Zhao, W. Enya, T. Aguilera, A. Acosta, I. Alonzo, F. Kiani, D. Behnsen, J. Alvarez, C. Keane, T. Adams, D. J. Lilue, J. Ross, S. R. 2024-05-01 doi:10.1101/2024.04.30.591891 Cold Spring Harbor Laboratory Press 2024-05-01 <![CDATA[ This microtubule does not exist: Super-resolution microscopy image generation by a diffusion model ]]> https://biorxiv.org/cgi/content/short/2023.07.06.548004v1?rss=1" Saguy, A. Nahimov, T. Lehrman, M. Alalouf, O. Shechtman, Y. 2023-07-07 doi:10.1101/2023.07.06.548004 Cold Spring Harbor Laboratory Press 2023-07-07