bioRxiv Subject Collection: Pharmacology And Toxicology
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This feed contains articles for bioRxiv Subject Collection "Pharmacology And Toxicology"
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Lipid-ASO therapeutics exhibit differential tissue targeted delivery upon systemic or local CNS administration
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https://www.biorxiv.org/content/10.64898/2026.08.28.747711v1?rss=1
2026-09-02doi:10.64898/2026.08.28.747711Cold Spring Harbor Laboratory2026-09-02
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Novel Dissymmetric Ionizable Lipid-Assembled Lipid Nanoparticles for Delivery of Ferroptosis-Related siRNA in Diabetic Treatment
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https://www.biorxiv.org/content/10.64898/2026.08.26.747432v1?rss=1
2026-09-01doi:10.64898/2026.08.26.747432Cold Spring Harbor Laboratory2026-09-01
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Caenorhabditis elegans as a Model to Dissect Pharmacokinetic and Pharmacodynamic Relationships of Gabapentinoids
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https://www.biorxiv.org/content/10.64898/2026.08.26.747285v1?rss=1
2026-08-31doi:10.64898/2026.08.26.747285Cold Spring Harbor Laboratory2026-08-31
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Inhibition of release of intestinal extracellular vesicles in Ascaris suum and immune modulation by the anthelminthic, ivermectin
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https://www.biorxiv.org/content/10.64898/2026.08.25.745816v1?rss=1
2026-08-28doi:10.64898/2026.08.25.745816Cold Spring Harbor Laboratory2026-08-28
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Human Lactoferrin is a Novel PFAS Target: Implications for Neo-natal Immune Function and Protein Stability
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https://www.biorxiv.org/content/10.64898/2026.08.25.746799v1?rss=1
2026-08-28doi:10.64898/2026.08.25.746799Cold Spring Harbor Laboratory2026-08-28
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State-dependent cannabidiol interactions with fentanyl-bound mouse μ-opioid receptor conformations: a three-state molecular dynamics study
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https://www.biorxiv.org/content/10.64898/2026.08.24.746804v1?rss=1
2026-08-27doi:10.64898/2026.08.24.746804Cold Spring Harbor Laboratory2026-08-27
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Interfacial water in the PRDX1-sulfiredoxin repair intermediate: an all-atom molecular dynamics study
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https://www.biorxiv.org/content/10.64898/2026.08.24.746838v1?rss=1
2026-08-27doi:10.64898/2026.08.24.746838Cold Spring Harbor Laboratory2026-08-27
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From TD50 to Benchmark Dose in Nitrosamine Risk Assessment: Evidence from N-Nitrosotrimetazidine Carcinogenicity and TGR Mutation Data.
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https://www.biorxiv.org/content/10.64898/2026.08.26.742063v1?rss=1
2026-08-27doi:10.64898/2026.08.26.742063Cold Spring Harbor Laboratory2026-08-27
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Inhibiting nociceptor endocytosis reduces MIA-induced osteoarthritic pain behavior
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https://www.biorxiv.org/content/10.64898/2026.08.21.746311v1?rss=1
2026-08-26doi:10.64898/2026.08.21.746311Cold Spring Harbor Laboratory2026-08-26
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Deep learning-mediated detection of accelerated water drinking after aquaresis in V1b vasopressin receptor knockout mice
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https://www.biorxiv.org/content/10.64898/2026.08.21.746202v1?rss=1
2026-08-25doi:10.64898/2026.08.21.746202Cold Spring Harbor Laboratory2026-08-25
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Dynamic BMP10 Release Reflects Atrial Fibrillation Burden in Human Atrial Engineered Heart Tissue
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https://www.biorxiv.org/content/10.64898/2026.08.20.746063v1?rss=1
2026-08-25doi:10.64898/2026.08.20.746063Cold Spring Harbor Laboratory2026-08-25
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Effects of vapor inhalation of 6-methyl nicotine in female and male rats
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https://www.biorxiv.org/content/10.64898/2026.08.20.746016v1?rss=1
2026-08-25doi:10.64898/2026.08.20.746016Cold Spring Harbor Laboratory2026-08-25
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Chili Pepper Flavourants in 'Heat" Oral Nicotine Pouches Marketed as Unflavoured in United States Jurisdictions Restricting Flavoured Tobacco Products
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https://www.biorxiv.org/content/10.64898/2026.08.19.745863v1?rss=1
2026-08-24doi:10.64898/2026.08.19.745863Cold Spring Harbor Laboratory2026-08-24
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DNCB shows hormetic effects in THP 1 cells: low-dose enhancement of metabolic activity
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https://www.biorxiv.org/content/10.64898/2026.08.19.745690v1?rss=1
2026-08-23doi:10.64898/2026.08.19.745690Cold Spring Harbor Laboratory2026-08-23
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Restoring neurovascular coupling in Alzheimer's disease tauopathy through M1 mAChR modulation
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https://www.biorxiv.org/content/10.64898/2026.08.18.745579v1?rss=1
2026-08-23doi:10.64898/2026.08.18.745579Cold Spring Harbor Laboratory2026-08-23
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Molecular size dominates α2-adrenergic subtype-selectivity benchmarks: five controls for reducing attrition in selective ligand design
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https://www.biorxiv.org/content/10.64898/2026.08.18.745649v1?rss=1
2026-08-23doi:10.64898/2026.08.18.745649Cold Spring Harbor Laboratory2026-08-23
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Antimicrobial cetylpyridinium chloride disrupts the mitochondrial electron transport chain as potently as cyanide, via cardiolipin interference at cytochrome C
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https://www.biorxiv.org/content/10.64898/2026.08.18.745331v1?rss=1
2026-08-22doi:10.64898/2026.08.18.745331Cold Spring Harbor Laboratory2026-08-22
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Lanifibranor (IVA-337) - a pan-PPAR agonist suppresses TGF-β1-induced cardiac fibrosis and rescues cardiomyocyte function
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https://www.biorxiv.org/content/10.64898/2026.08.18.745414v1?rss=1
2026-08-21doi:10.64898/2026.08.18.745414Cold Spring Harbor Laboratory2026-08-21
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Salicyl-Carnosine Protects Primary Cortical Rat Neuron Cultures in Conditions of Oxygen-Glucose Deprivation and NMDA-Induced Excitotoxicity by Preventing Oxidative Stress
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https://www.biorxiv.org/content/10.64898/2026.08.07.743511v1?rss=1
2026-08-17doi:10.64898/2026.08.07.743511Cold Spring Harbor Laboratory2026-08-17
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Systematic assessment of transcriptomic and phenotypic biological profiling for mechanism-based hazard assessment using target-annotated reference chemicals in renal proximal tubular epithelial cells
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https://www.biorxiv.org/content/10.64898/2026.08.08.743660v1?rss=1
2026-08-17doi:10.64898/2026.08.08.743660Cold Spring Harbor Laboratory2026-08-17
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Exposure Duration Shapes the Hepatic Response to GenX: Divergent Acute and Chronic Transcriptomic Profiles Reveal Non-Monotonic Dose Effects and Increased Sensitivity in Human Liver Spheroids
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https://www.biorxiv.org/content/10.64898/2026.08.08.743693v1?rss=1
2026-08-18doi:10.64898/2026.08.08.743693Cold Spring Harbor Laboratory2026-08-18
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A small molecule inhibitor of CD28 costimulation restrains pathogenic T-cell responses in inflammatory bowel disease
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https://www.biorxiv.org/content/10.64898/2026.08.10.744081v1?rss=1
2026-08-18doi:10.64898/2026.08.10.744081Cold Spring Harbor Laboratory2026-08-18
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Hepatic estrogen receptor α is required for stage-specific coupling of liver metabolism and proliferation during pregnancy
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https://www.biorxiv.org/content/10.64898/2026.08.10.743939v1?rss=1
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Long-read sequencing quantifies synthetic mRNA abundance, integrity and host response in vivo
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https://www.biorxiv.org/content/10.64898/2026.08.10.741180v1?rss=1
2026-08-19doi:10.64898/2026.08.10.741180Cold Spring Harbor Laboratory2026-08-19
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Role of Nutritional Status on Arsenic Toxicity in Daphnia pulex: A Transcriptomic Perspective on Individual and Interactive Effects
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https://www.biorxiv.org/content/10.64898/2026.08.11.744190v1?rss=1
2026-08-19doi:10.64898/2026.08.11.744190Cold Spring Harbor Laboratory2026-08-19
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Protective Effects of Boric Acid Against LPS-Induced Inflammation and Apoptosis in a Primary Human Chondrocyte Model of Osteoarthritis
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https://www.biorxiv.org/content/10.64898/2026.08.13.744490v1?rss=1
2026-08-20doi:10.64898/2026.08.13.744490Cold Spring Harbor Laboratory2026-08-20
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The KRAS G12C Inhibitor Divarasib Stabilizes RBM39 and Antagonizes Aryl-Sulfonamide Degraders
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https://www.biorxiv.org/content/10.64898/2026.08.16.745134v1?rss=1
2026-08-20doi:10.64898/2026.08.16.745134Cold Spring Harbor Laboratory2026-08-20
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An AI System for Autonomous Algorithm Evolution in Drug Development
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https://www.biorxiv.org/content/10.64898/2026.08.16.745117v1?rss=1
2026-08-20doi:10.64898/2026.08.16.745117Cold Spring Harbor Laboratory2026-08-20
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Phytometabolite-Enriched Edible Plant-Derived Extracellular Vesicles Exhibit Source-Specific Bioactives with Distinct Pharmacological Potential
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https://www.biorxiv.org/content/10.64898/2026.08.17.742983v1?rss=1
8-fold, p<0.05), occludin (>2-fold, p<0.05). Ginger EVs restored ZO 1 while suppressing cyclin D1 and MMP9(p<0.05). Garlic and turmeric EVs attenuated inflammatory signaling by reducing STAT3, AKT1, and TNF , whereas turmeric EVs additionally decreased caspase 3 and PTGS2(p<0.01). In steatotic hepatocytes, garlic EVs significantly reduced PNPLA3 (p<0.001) and SREBP 1c while increasing PPAR- (p=0.002). Hence, our results indicate that edible PDEVs are gastrointestinally stable, phytometabolite enriched nanocarriers with distinct source specific functional properties, supporting their potential as orally deliverable nutraceuticals for improving gut liver functions.
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Discovery and optimization of the next generation of cell active Protein Kinase Novel 3 (PKN3) inhibitors
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https://www.biorxiv.org/content/10.64898/2026.08.20.745975v1?rss=1
2026-08-20doi:10.64898/2026.08.20.745975Cold Spring Harbor Laboratory2026-08-20