bioRxiv Subject Collection: Genetics
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This feed contains articles for bioRxiv Subject Collection "Genetics"
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The Effect of Depriving the Aedes aegypti Mosquito of Natural Levels of Radiation
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https://www.biorxiv.org/content/10.64898/2026.06.29.735377v1?rss=1
2026-07-03doi:10.64898/2026.06.29.735377Cold Spring Harbor Laboratory2026-07-03
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Pangenome-based human genome analysis improves trait association and genomic prediction
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https://www.biorxiv.org/content/10.64898/2026.07.01.735728v1?rss=1
0.05). Taken together, these results suggest that integration of pangenomic methods into human genetic studies will improve trait association and genomic prediction at a meaningful subset of genes.
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Towards genetic indicators in ectomycorrhizal fungi: estimating the effective population size
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https://www.biorxiv.org/content/10.64898/2026.06.30.735680v1?rss=1
2026-07-03doi:10.64898/2026.06.30.735680Cold Spring Harbor Laboratory2026-07-03
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Preclinical translation of Neurofibromatosis type 1 (NF1) exon 17 skipping using targeted U7-SnRNA packaged into engineered AAV serotypes.
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https://www.biorxiv.org/content/10.64898/2026.06.29.734312v1?rss=1
2026-07-02doi:10.64898/2026.06.29.734312Cold Spring Harbor Laboratory2026-07-02
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CATaN maps gene regulatory programs that shape genetic risk across complex diseases
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https://www.biorxiv.org/content/10.64898/2026.06.28.735120v1?rss=1
2026-07-02doi:10.64898/2026.06.28.735120Cold Spring Harbor Laboratory2026-07-02
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Paralogs of the <em>Candida albicans TLO</em> gene family form interconnected functional networks with incomplete redundancy
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https://www.biorxiv.org/content/10.64898/2026.06.29.735307v1?rss=1
Candida albicans telomere-associated (TLO) gene family to test the redundancy in molecular and biological function among paralogs from a lineage-specific expansion. Tlo proteins function as interchangeable subunits of the Mediator transcriptional regulatory complex and have the potential to alter gene expression and an array of cellular responses. Redundancy was the most common outcome, being observed for approximately 80% of the phenotypic assays in strains lacking single TLO genes. However, mutants for all 14 paralogs displayed non-redundant functions in phenotypes ranging from carbon utilization to in vivo virulence. Analysis of gene expression in single TLO mutants found similar trends in redundancy, and loss of single TLOs disproportionately affected genes involved in filamentation, adhesion, redox reactions, and transporter activity at the cell surface. Importantly, sequence divergence between paralogs positively correlated with the frequency of altered phenotypes in single TLO mutants, indicating the acquisition of non-redundant function with increased evolutionary distance. Double mutants lacking two TLO genes produced both positive and negative synergistic phenotypes, suggesting that crosstalk or coordinated regulation is common among paralogs. Together, this study demonstrates that recently emergent paralogs acquire non-redundant functions despite often retaining redundancy with other gene family members to form a highly interconnected functional network.
]]>2026-07-02doi:10.64898/2026.06.29.735307Candida albicans TLO gene family form interconnected functional networks with incomplete redundancy]]>Cold Spring Harbor Laboratory2026-07-02
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Effects of Deficient Glycosylation and Deglycosylation on Sperm Condition in Zebrafish (Danio rerio)
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https://www.biorxiv.org/content/10.64898/2026.07.01.735899v1?rss=1
2026-07-02doi:10.64898/2026.07.01.735899Cold Spring Harbor Laboratory2026-07-02
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The impact of P-Element-induced hybrid dysgenesis on the male germline in Drosophila simulans
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https://www.biorxiv.org/content/10.64898/2026.06.28.735054v1?rss=1
2026-07-01doi:10.64898/2026.06.28.735054Cold Spring Harbor Laboratory2026-07-01
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Female genetic variation controlling timing of mating plug ejection in Drosophila melanogaster
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https://www.biorxiv.org/content/10.64898/2026.06.27.734984v1?rss=1
2026-07-01doi:10.64898/2026.06.27.734984Cold Spring Harbor Laboratory2026-07-01
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Formation, persistence, and breakdown of carrier-set topology in linkage disequilibrium: empirical structure in 1000 Genomes and a two locus Wright Fisher model
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https://www.biorxiv.org/content/10.64898/2026.07.01.735767v1?rss=1
2026-07-01doi:10.64898/2026.07.01.735767Cold Spring Harbor Laboratory2026-07-01
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A geometric representation of gene-by-gene and gene-by-environment interactions on the extended complex plane
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https://www.biorxiv.org/content/10.64898/2026.06.26.734831v1?rss=1
2026-07-01doi:10.64898/2026.06.26.734831Cold Spring Harbor Laboratory2026-07-01
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An axiomatic approach to cultivar ranking in multi-environment trials
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https://www.biorxiv.org/content/10.64898/2026.06.27.734959v1?rss=1
2026-07-01doi:10.64898/2026.06.27.734959Cold Spring Harbor Laboratory2026-07-01
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Revising the genetic and epigenetic architecture of in vitro regeneration capacity in natural Arabidopsis thaliana populations
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https://www.biorxiv.org/content/10.64898/2026.06.26.734650v1?rss=1
2026-07-01doi:10.64898/2026.06.26.734650Cold Spring Harbor Laboratory2026-07-01
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Pathogenic impact of ABCA4 missense variants in the structurally uncharacterized ECD1 region: implications for Stargardt disease.
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https://www.biorxiv.org/content/10.64898/2026.06.25.734683v1?rss=1
2026-07-01doi:10.64898/2026.06.25.734683Cold Spring Harbor Laboratory2026-07-01
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Genome architecture shapes the evolutionary origins of redundant enhancers in fly and mouse
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https://www.biorxiv.org/content/10.64898/2026.06.26.734851v1?rss=1
2026-07-01doi:10.64898/2026.06.26.734851Cold Spring Harbor Laboratory2026-07-01
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Epigenetic signatures of infection within and across generations in the endangered Loggerhead sea turtle
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https://www.biorxiv.org/content/10.64898/2026.06.25.734236v1?rss=1
2026-06-30doi:10.64898/2026.06.25.734236Cold Spring Harbor Laboratory2026-06-30
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Gut-derived serine protease reduces sleep but extends lifespan
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https://www.biorxiv.org/content/10.64898/2026.06.25.734557v1?rss=1
2026-06-29doi:10.64898/2026.06.25.734557Cold Spring Harbor Laboratory2026-06-29
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Intestinal lipid metabolism controls immune response through NHR-68 and gut-brain signaling in C. elegans
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https://www.biorxiv.org/content/10.64898/2026.06.24.734305v1?rss=1
2026-06-29doi:10.64898/2026.06.24.734305Cold Spring Harbor Laboratory2026-06-29
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Haplotype-specific chromosome painting unveils recombination patterns in the holocentric species Rhynchospora breviuscula H.Pfeiff.
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https://www.biorxiv.org/content/10.64898/2026.06.24.733714v1?rss=1
2026-06-29doi:10.64898/2026.06.24.733714Cold Spring Harbor Laboratory2026-06-29
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Paralogous lncRNAs CYTOR and MORRBID share a conserved trans acting function in MEK ERK signaling
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https://www.biorxiv.org/content/10.64898/2026.06.24.734157v1?rss=1
2026-06-29doi:10.64898/2026.06.24.734157Cold Spring Harbor Laboratory2026-06-29
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A cryptic local genetic cluster in Northern France amid the European mosaic of flat oyster lineages revealed by integrating SNP array and whole-genome sequencing
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https://www.biorxiv.org/content/10.64898/2026.06.26.734753v1?rss=1
2026-06-28doi:10.64898/2026.06.26.734753Cold Spring Harbor Laboratory2026-06-28
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Genomic insights into bacterial kidney disease resistance in Arctic charr (Salvelinus alpinus) via a 72k SNP array
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https://www.biorxiv.org/content/10.64898/2026.06.25.734482v1?rss=1
2026-06-27doi:10.64898/2026.06.25.734482Cold Spring Harbor Laboratory2026-06-27
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Genetic Association of Somatic Incompatibility and NLR-like Protein Domains in Coprinopsis cinerea
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https://www.biorxiv.org/content/10.64898/2026.06.24.733965v1?rss=1
2026-06-27doi:10.64898/2026.06.24.733965Cold Spring Harbor Laboratory2026-06-27
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Transformation and allelic exchange in Orientia tsutsugamushi
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https://www.biorxiv.org/content/10.64898/2026.06.22.733791v1?rss=1
2026-06-26doi:10.64898/2026.06.22.733791Cold Spring Harbor Laboratory2026-06-26
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Evaluating the potential role and contribution of transposable elements to the evolution of microbial multicellularity across the tree of eukaryotes
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https://www.biorxiv.org/content/10.64898/2026.06.24.734286v1?rss=1
2026-06-25doi:10.64898/2026.06.24.734286Cold Spring Harbor Laboratory2026-06-25
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Defining the molecular tolerance-to-damage landscape of SMARCA4 helicase genetic alterations
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https://www.biorxiv.org/content/10.64898/2026.06.22.733755v1?rss=1
2026-06-24doi:10.64898/2026.06.22.733755Cold Spring Harbor Laboratory2026-06-24
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Primary-Level Meta-Analysis of Diversity Outbred Mice Identifies a Fasting Plasma Trimethylamine N-Oxide (TMAO) Locus Modified by Sex and Diet
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https://www.biorxiv.org/content/10.64898/2026.06.19.733321v1?rss=1
2026-06-24doi:10.64898/2026.06.19.733321Cold Spring Harbor Laboratory2026-06-24
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Large-scale meta-analysis of over one million individuals reveals the genetic architecture of 127 complex traits in East Asian populations
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https://www.biorxiv.org/content/10.64898/2026.06.18.730290v1?rss=1
2026-06-23doi:10.64898/2026.06.18.730290Cold Spring Harbor Laboratory2026-06-23
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Repair outcomes after germline homing endonuclease cleavage in Anopheles gambiae inform the design of synthetic gene drives
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https://www.biorxiv.org/content/10.64898/2026.06.23.733901v1?rss=1
2026-06-23doi:10.64898/2026.06.23.733901Cold Spring Harbor Laboratory2026-06-23
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Is APOE ε2 always a protective allele? Deviations in Hardy-Weinberg equilibrium in admixed Brazilian elderly individuals
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https://www.biorxiv.org/content/10.64898/2026.06.20.733520v1?rss=1
2026-06-23doi:10.64898/2026.06.20.733520Cold Spring Harbor Laboratory2026-06-23