bioRxiv Subject Collection: Cell Biology
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This feed contains articles for bioRxiv Subject Collection "Cell Biology"
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Sex-differentiated hormonal microenvironments recapitulate in vivo liver metabolism in human iPSC-derived organoids
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https://www.biorxiv.org/content/10.64898/2026.05.09.723948v1?rss=1
2026-05-12doi:10.64898/2026.05.09.723948Cold Spring Harbor Laboratory2026-05-12
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Targeting cancer-associated cell surface RNAs with oligonucleotide-drug conjugates enables broad antitumor activity
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https://www.biorxiv.org/content/10.64898/2026.05.08.723688v1?rss=1
2026-05-12doi:10.64898/2026.05.08.723688Cold Spring Harbor Laboratory2026-05-12
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Size-dependent nucleus-vacuole interactions in budding yeast demonstrate a role for steric packing in organelle shape and positioning
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https://www.biorxiv.org/content/10.64898/2026.05.08.723889v1?rss=1
2026-05-12doi:10.64898/2026.05.08.723889Cold Spring Harbor Laboratory2026-05-12
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A genome-wide RNAi screen identifies host cell cycle regulation as a determinant of Orientia tsutsugamushi infection
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https://www.biorxiv.org/content/10.64898/2026.05.08.723767v1?rss=1
2026-05-12doi:10.64898/2026.05.08.723767Cold Spring Harbor Laboratory2026-05-12
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The proximal lipid phase of PI3K signaling is confined to the plasma membrane
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https://www.biorxiv.org/content/10.64898/2026.05.08.723799v1?rss=1
2026-05-12doi:10.64898/2026.05.08.723799Cold Spring Harbor Laboratory2026-05-12
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HS3ST1 regulates pulmonary inflammation and is a determinant of clinical outcomes after trauma and hemorrhagic shock
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https://www.biorxiv.org/content/10.64898/2026.05.07.723543v1?rss=1
2026-05-12doi:10.64898/2026.05.07.723543Cold Spring Harbor Laboratory2026-05-12
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Decoding murine corneal epithelial specification and homeostasis by single-cell spatial transcriptomics with scRNA-seq enrichment
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https://www.biorxiv.org/content/10.64898/2026.05.08.723186v1?rss=1
2026-05-12doi:10.64898/2026.05.08.723186Cold Spring Harbor Laboratory2026-05-12
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A CAMKK2-UBR4-19S Proteasome Axis Regulates Chondrocyte Proteostasis and SOX9 Stability
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https://www.biorxiv.org/content/10.64898/2026.05.07.723609v1?rss=1
2026-05-12doi:10.64898/2026.05.07.723609Cold Spring Harbor Laboratory2026-05-12
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Benzopyrene induces keratinocyte senescence and p21-dependent differentiation
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https://www.biorxiv.org/content/10.64898/2026.05.08.723713v1?rss=1
2026-05-12doi:10.64898/2026.05.08.723713Cold Spring Harbor Laboratory2026-05-12
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Alternative organelle targeting of OPA1 mediates fatty acid release from lipid droplets
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https://www.biorxiv.org/content/10.64898/2026.05.07.723579v1?rss=1
2026-05-11doi:10.64898/2026.05.07.723579Cold Spring Harbor Laboratory2026-05-11
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Liver sinusoidal endothelial cells integrate metabolic and immune signals for MAPK-dependent BMP6 regulation and hepcidin induction
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https://www.biorxiv.org/content/10.64898/2026.05.07.723498v1?rss=1
2026-05-11doi:10.64898/2026.05.07.723498Cold Spring Harbor Laboratory2026-05-11
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Cannabidiol confers neuroprotection against 6-OHDA toxicity by rescuing Nrf2 proteostasis and preserving mitochondrial integrity
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https://www.biorxiv.org/content/10.64898/2026.05.07.723512v1?rss=1
2026-05-11doi:10.64898/2026.05.07.723512Cold Spring Harbor Laboratory2026-05-11
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Angiotensin II and cAMP signaling pathways regulate mitochondrial biogenesis and activity in human adrenocortical cells.
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https://www.biorxiv.org/content/10.64898/2026.05.06.723032v1?rss=1
2026-05-11doi:10.64898/2026.05.06.723032Cold Spring Harbor Laboratory2026-05-11
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Talin controls the spatial distribution of vinculin tension in focal adhesions
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https://www.biorxiv.org/content/10.64898/2026.05.07.722930v1?rss=1
2026-05-11doi:10.64898/2026.05.07.722930Cold Spring Harbor Laboratory2026-05-11
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Quantitative analysis of fibroblast migration reveals migratory states characterized by force generation, cell shape and motion
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https://www.biorxiv.org/content/10.64898/2026.05.06.723282v1?rss=1
2026-05-11doi:10.64898/2026.05.06.723282Cold Spring Harbor Laboratory2026-05-11
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NO modulates human airway smooth muscle function by altering glucose-6-phosphate dehydrogenase effects on sGC function in asthma
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https://www.biorxiv.org/content/10.64898/2026.05.06.723287v1?rss=1
2026-05-11doi:10.64898/2026.05.06.723287Cold Spring Harbor Laboratory2026-05-11
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Compartmentalized glycolysis powers ATP production in primary cilia and engages mitochondria via the phosphoenolpyruvate cycle
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https://www.biorxiv.org/content/10.64898/2026.05.06.723011v1?rss=1
2026-05-11doi:10.64898/2026.05.06.723011Cold Spring Harbor Laboratory2026-05-11
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USP10 Facilitates Homologous Recombination-Mediated DNA Double-Strand Break Repair through Localization to the Nucleolus
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https://www.biorxiv.org/content/10.64898/2026.05.07.723676v1?rss=1
2026-05-11doi:10.64898/2026.05.07.723676Cold Spring Harbor Laboratory2026-05-11
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Dual role of the OMM E3 Ub ligase MARCH5 in de novo peroxisome biogenesis and mitochondrial quality control through direct regulation of Pex26.
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https://www.biorxiv.org/content/10.64898/2026.05.06.723346v1?rss=1
2026-05-11doi:10.64898/2026.05.06.723346Cold Spring Harbor Laboratory2026-05-11
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A cohesion optimum underlies chromosome segregation fidelity in oocytes
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https://www.biorxiv.org/content/10.64898/2026.05.08.723885v1?rss=1
2026-05-11doi:10.64898/2026.05.08.723885Cold Spring Harbor Laboratory2026-05-11
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Rap1 Activates Endosomal AC9 to Drive the Second cAMP Wave
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https://www.biorxiv.org/content/10.64898/2026.05.06.723328v1?rss=1
2026-05-11doi:10.64898/2026.05.06.723328Cold Spring Harbor Laboratory2026-05-11
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Transcriptional remodeling of ubiquitin regulatory networks during trained immunity
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https://www.biorxiv.org/content/10.64898/2026.05.06.723281v1?rss=1
2026-05-10doi:10.64898/2026.05.06.723281Cold Spring Harbor Laboratory2026-05-10
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Coordinated cell and chloroplast growth and its perturbation by chloroplast DNA replication inhibition in green algae
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https://www.biorxiv.org/content/10.64898/2026.05.06.723297v1?rss=1
2026-05-10doi:10.64898/2026.05.06.723297Cold Spring Harbor Laboratory2026-05-10
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In vivo base editing via single myotrophic adeno-associated viruses in dystrophic mouse muscle and satellite cells
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https://www.biorxiv.org/content/10.64898/2026.05.09.721064v1?rss=1
2026-05-10doi:10.64898/2026.05.09.721064Cold Spring Harbor Laboratory2026-05-10
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Differential tolerance for SEA domain misfolding encodes a MAPK pathway-specific response
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https://www.biorxiv.org/content/10.64898/2026.05.06.723240v1?rss=1
View larger version (50K):
org.highwire.dtl.DTLVardef@20aorg.highwire.dtl.DTLVardef@85f517org.highwire.dtl.DTLVardef@9dd3f1org.highwire.dtl.DTLVardef@1c5976f_HPS_FORMAT_FIGEXP M_FIG C_FIG Signaling pathways often share components yet activate different effector processes through mechanisms that remain unclear. The same mucin regulates two MAPK pathways (red and green), and the discovery of a conserved SEA domain provided insights into specificity mechanisms. In the fMAPK pathway that regulates filamentous growth, the mucin works in a classical manner, where an external signal (in this case underglycosylation by glucose limitation) transduces a signal to the cytosolic domain in cis. By comparison, the HOG pathway that responds to osmotic stress displayed a remarkable tolerance for mucin and SEA domain deformation. Protein variants that caused SEA domain misfolding, mislocalization, and degradation by ERAD retained function in the HOG pathway. Truncations that removed the cytosolic tail and transmembrane anchor were also functional. These phenotypes support a trans activation mechanism with external partners that was preferential for activation of the HOG pathway. SEA domain deformation may be induced by environmental stress as a trigger for the HOG pathway. Cells may detect misfolding of protein domains to gain information about environmental stress.
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ILK binding to β1 Integrin is indirectly mediated by Kindlin-2
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https://www.biorxiv.org/content/10.64898/2026.05.06.723202v1?rss=1
2026-05-09doi:10.64898/2026.05.06.723202Cold Spring Harbor Laboratory2026-05-09
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Selective Elimination of TP53 Mutant Cells by Transcript-Activated Chromatin Shredding
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https://www.biorxiv.org/content/10.64898/2026.05.08.723607v1?rss=1
2026-05-09doi:10.64898/2026.05.08.723607Cold Spring Harbor Laboratory2026-05-09
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NFIC-mediated CaSR endocytosis defines a hyperactive TOMM20highCHGAhigh oxyphil cell state as a pathological driver of autonomous secondary hyperparathyroidism
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https://www.biorxiv.org/content/10.64898/2026.05.06.723114v1?rss=1
2026-05-09doi:10.64898/2026.05.06.723114Cold Spring Harbor Laboratory2026-05-09
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Septin crosstalk with microtubules and actin is regulated by a GSK3-dependent phosphoswitch
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https://www.biorxiv.org/content/10.64898/2026.05.06.723191v1?rss=1
2026-05-09doi:10.64898/2026.05.06.723191Cold Spring Harbor Laboratory2026-05-09
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Temporal regulation of G2 phase avoids therapy-induced senescence caused by DNA replication stress-inducing drugs and provides synergistic cytotoxicity
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https://www.biorxiv.org/content/10.64898/2026.05.06.723184v1?rss=1
2026-05-09doi:10.64898/2026.05.06.723184Cold Spring Harbor Laboratory2026-05-09