bioRxiv Subject Collection: Cancer Biology
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This feed contains articles for bioRxiv Subject Collection "Cancer Biology"
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Oncogenic Ras-Src-cortactin signaling rewires actin-generated forces to drive basement membrane rupture and initiate breast cancer invasion
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https://www.biorxiv.org/content/10.64898/2026.04.15.717430v1?rss=1
2026-04-18doi:10.64898/2026.04.15.717430Cold Spring Harbor Laboratory2026-04-18
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Therapy-associated mutagenesis at CTCF binding sites is shaped by chromatin context and DNA repair capacity
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https://www.biorxiv.org/content/10.64898/2026.04.15.718780v1?rss=1
2026-04-18doi:10.64898/2026.04.15.718780Cold Spring Harbor Laboratory2026-04-18
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An Endocytic Checkpoint Controls Macrophage PD-1 Function and Immunotherapy Fate
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https://www.biorxiv.org/content/10.64898/2026.04.14.718292v1?rss=1
12,500 transcriptomes) with single-cell profiles from >1,000 anti PD1 treated patients, to identify CCDC88A (GIV) as a macrophage-intrinsic determinant of durable response versus HPD. GIV loss increases PD1 surface retention, suppresses phagocytosis, and accelerates tumor growth across murine models, human macrophages, and patient-derived organoids. Myeloid-specific GIV deletion converts PD1 blockade from tumor-restraining to tumor-accelerating by reprogramming macrophages toward HPD-like states. Mechanistically, GIV engages a conserved TIR-like [TILL] motif within the PD1 cytoplasmic tail to drive dynamin-dependent endocytosis, coupling innate immune signaling logic to checkpoint receptor trafficking. Pharmacologic disruption of this axis phenocopies GIV loss, revealing an endocytic vulnerability that undermines checkpoint efficacy and triggers accelerated growth at relapse. These findings define PD1 routing, rather than ligand-binding, as a macrophage-encoded checkpoint governing antitumor immunity.
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KDM6 Enzymes are the Mechanistic Targets of Mutant IDH that Dictate Replication Stress Sensitivity
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https://www.biorxiv.org/content/10.64898/2026.04.14.715350v1?rss=1
2026-04-17doi:10.64898/2026.04.14.715350Cold Spring Harbor Laboratory2026-04-17
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Pairwise genomic alterations identify prognostic tumor states in multiple cancer types
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https://www.biorxiv.org/content/10.64898/2026.04.14.718563v1?rss=1
2026-04-17doi:10.64898/2026.04.14.718563Cold Spring Harbor Laboratory2026-04-17
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Multiomic screening platform uncovers the impact of histone mutations on chromatin and cell fate
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https://www.biorxiv.org/content/10.64898/2026.04.14.718582v1?rss=1
2026-04-17doi:10.64898/2026.04.14.718582Cold Spring Harbor Laboratory2026-04-17
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Metabolic Salvage and Acyl-chain Remodeling Support Glycosphingolipid Synthesis with the PDAC Tumor Microenvironment
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https://www.biorxiv.org/content/10.64898/2026.04.14.718544v1?rss=1
2026-04-17doi:10.64898/2026.04.14.718544Cold Spring Harbor Laboratory2026-04-17
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Modeling VEGF and GLUT1 Expression as Coadapted Foraging Strategies in Cancer
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https://www.biorxiv.org/content/10.64898/2026.04.14.718570v1?rss=1
2026-04-17doi:10.64898/2026.04.14.718570Cold Spring Harbor Laboratory2026-04-17
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Stem Cell Divisions, Driver Mutations, and Carcinogenesis in Purebred Dogs
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https://www.biorxiv.org/content/10.64898/2026.04.14.718346v1?rss=1
2026-04-17doi:10.64898/2026.04.14.718346Cold Spring Harbor Laboratory2026-04-17
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Disruption of PI3K/OxPhos Coupling by Trehalose Drives a BCAA to Lipid Metabolic Switch in Hormone Receptor Positive Breast Cancer
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https://www.biorxiv.org/content/10.64898/2026.04.14.718262v1?rss=1
2026-04-17doi:10.64898/2026.04.14.718262Cold Spring Harbor Laboratory2026-04-17
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Identification of Bone Morphogenetic Protein 7 as a Master Regulator of Gastric Cancer-Associated Cachexia
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https://www.biorxiv.org/content/10.64898/2026.04.13.717813v1?rss=1
2026-04-17doi:10.64898/2026.04.13.717813Cold Spring Harbor Laboratory2026-04-17
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Multimodal immunopharmacologic screens identify drugs rewiring the cancer-immune interface
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https://www.biorxiv.org/content/10.64898/2026.04.13.717771v1?rss=1
2026-04-17doi:10.64898/2026.04.13.717771Cold Spring Harbor Laboratory2026-04-17
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KIF18A Maintains Kinetochore-Microtubule Attachments in CIN Cells by Limiting Microtubule Polymerization
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https://www.biorxiv.org/content/10.64898/2026.04.15.718686v1?rss=1
2026-04-17doi:10.64898/2026.04.15.718686Cold Spring Harbor Laboratory2026-04-17
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Pan-cancer circular genomics identifies intratumoral Staphylococcus lugdunensis as a metabolic driver in bladder cancer
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https://www.biorxiv.org/content/10.64898/2026.04.14.717102v1?rss=1
2026-04-16doi:10.64898/2026.04.14.717102Cold Spring Harbor Laboratory2026-04-16
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SImBA-SiQuAl: a new tool enabling high-content high-throughput phenotypic profiling of 3D microtumours.
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https://www.biorxiv.org/content/10.64898/2026.04.14.718366v1?rss=1
2026-04-16doi:10.64898/2026.04.14.718366Cold Spring Harbor Laboratory2026-04-16
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Adaptive Cancer Suppression among Tissues through Reduced Stem Cell Mutation Rates
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https://www.biorxiv.org/content/10.64898/2026.04.13.718347v1?rss=1
2026-04-16doi:10.64898/2026.04.13.718347Cold Spring Harbor Laboratory2026-04-16
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Metabolic maintenance of breast cancer cells and metastases throughE-cadherin/YAP-dependent pyruvate carboxylase expression
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https://www.biorxiv.org/content/10.64898/2026.04.13.718309v1?rss=1
2026-04-16doi:10.64898/2026.04.13.718309Cold Spring Harbor Laboratory2026-04-16
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Regression-based Modeling of Spearman's Rho for Longitudinal Metabolomics and Mental Wellness in Breast Cancer Patients
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https://www.biorxiv.org/content/10.64898/2026.04.13.718341v1?rss=1
2026-04-16doi:10.64898/2026.04.13.718341Cold Spring Harbor Laboratory2026-04-16
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WNT-driven chromosomal instability as a biomarker for PORCN inhibition
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https://www.biorxiv.org/content/10.64898/2026.04.13.718275v1?rss=1
2026-04-15doi:10.64898/2026.04.13.718275Cold Spring Harbor Laboratory2026-04-15
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Enforced ZFP281 expression delays breast cancer initiation and can provide lifelong protection against breast cancer metastasis
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https://www.biorxiv.org/content/10.64898/2026.04.13.718280v1?rss=1
2026-04-15doi:10.64898/2026.04.13.718280Cold Spring Harbor Laboratory2026-04-15
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Loss of Mast cells and histaminergic signaling link diet to platelet-mediated NETosis and mammary cancer recurrence
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https://www.biorxiv.org/content/10.64898/2026.04.14.718388v1?rss=1
2026-04-15doi:10.64898/2026.04.14.718388Cold Spring Harbor Laboratory2026-04-15
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Specific Aneuploidies Predict Immune Evasion and Poor Immunotherapy Response in Melanoma
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https://www.biorxiv.org/content/10.64898/2026.04.12.718039v1?rss=1
2026-04-15doi:10.64898/2026.04.12.718039Cold Spring Harbor Laboratory2026-04-15
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Mutant KRAS promotes NF-kB driven CCL20 chemokine expression in pancreatic ductal adenocarcinoma
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https://www.biorxiv.org/content/10.64898/2026.04.13.717530v1?rss=1
2026-04-15doi:10.64898/2026.04.13.717530Cold Spring Harbor Laboratory2026-04-15
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Enzyme activity as an actionable axis for small-molecule precision oncology
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https://www.biorxiv.org/content/10.64898/2026.04.14.717586v1?rss=1
2026-04-15doi:10.64898/2026.04.14.717586Cold Spring Harbor Laboratory2026-04-15
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DLG2-DLG4 expression in lower-grade glioma is associated with improved survival and an excitatory synaptic transmission and plasticity gene signature
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https://www.biorxiv.org/content/10.64898/2026.04.13.718176v1?rss=1
2026-04-15doi:10.64898/2026.04.13.718176Cold Spring Harbor Laboratory2026-04-15
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Benchmarking scRNA-seq Copy Number Inference: A Comprehensive Evaluation and Practitioner Guide
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https://www.biorxiv.org/content/10.64898/2026.04.12.718050v1?rss=1
100,000 cells) and diverse synthetic datasets. By evaluating methods based on malignant cell classification accuracy, CNV inference accuracy, scalability, and robustness, we establish a definitive practitioners guideline: allele-aware methods like Numbat excel when high-quality allelic inference can be achieved, whereas expression-centric tools such as Clonalscope, CopyKAT, inferCNV, and SCEVAN remain reliable when raw sequencing data are unavailable. Our study provides both a practical decision-making framework for researchers and a public repository of standardized CNV profiles to catalyze further methodological innovation.
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Sacituzumab Govitecan as an Effective Strategy for Sensitizing Chemoresistant HNSCC Cells to Senolytic Intervention
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https://www.biorxiv.org/content/10.64898/2026.04.13.718209v1?rss=1
2026-04-15doi:10.64898/2026.04.13.718209Cold Spring Harbor Laboratory2026-04-15
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Progastrin activates colonic fibroblasts and induces a paracrine pro-migratory program in colorectal cancer cells
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https://www.biorxiv.org/content/10.64898/2026.04.12.718027v1?rss=1
2026-04-15doi:10.64898/2026.04.12.718027Cold Spring Harbor Laboratory2026-04-15
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Tetrahydrocurcumin Suppresses Bladder Carcinogenesis via Reprogramming O-GlcNAcylation-Phosphorylation Crosstalk
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https://www.biorxiv.org/content/10.64898/2026.04.12.717994v1?rss=1
2026-04-15doi:10.64898/2026.04.12.717994Cold Spring Harbor Laboratory2026-04-15
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Cell fusion reprograms tumor cells and promotes RUNX1-mediated invasion and dissemination in colorectal cancer
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https://www.biorxiv.org/content/10.64898/2026.04.12.717781v1?rss=1
2026-04-15doi:10.64898/2026.04.12.717781Cold Spring Harbor Laboratory2026-04-15