bioRxiv Subject Collection: Biochemistry
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This feed contains articles for bioRxiv Subject Collection "Biochemistry"
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Structural basis of the nucleotide incorporation cycle of bacterial DNA polymerase III
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https://www.biorxiv.org/content/10.64898/2026.06.29.735100v1?rss=1
2026-06-29doi:10.64898/2026.06.29.735100Cold Spring Harbor Laboratory2026-06-29
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Sequential Penta-Omic Extraction Method Using Single Biospecimens of Post-mortem Human Brain
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https://www.biorxiv.org/content/10.64898/2026.06.26.734872v1?rss=1
2026-06-29doi:10.64898/2026.06.26.734872Cold Spring Harbor Laboratory2026-06-29
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Intact and single-molecule analysis of heparan sulfate
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https://www.biorxiv.org/content/10.64898/2026.06.26.734651v1?rss=1
2026-06-29doi:10.64898/2026.06.26.734651Cold Spring Harbor Laboratory2026-06-29
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CAGE-TRX expands the scope of time-resolved crystallography through genetically encoded active-site photocaging
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https://www.biorxiv.org/content/10.64898/2026.06.26.734858v1?rss=1
2026-06-29doi:10.64898/2026.06.26.734858Cold Spring Harbor Laboratory2026-06-29
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In Vivo Quantification of Histone Acetylation Turnover and Acetyl-CoA Sources Using 2H2O Metabolic Labeling and High-Resolution Mass Spectrometry.
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https://www.biorxiv.org/content/10.64898/2026.06.26.734905v1?rss=1
60% of acetylation used carbon). This approach enables simultaneous in vivo assessment of histone acetylation turnover, site occupancy, and acetyl-CoA substrate utilization, offering a robust platform to investigate metabolic-epigenetic crosstalk in health and disease.
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Incorporating Surfaced-Induced Dissociation Mass Spectrometry Data into an AlphaFold-derived deep learning network improves protein structure prediction
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https://www.biorxiv.org/content/10.64898/2026.06.26.734850v1?rss=1
2026-06-29doi:10.64898/2026.06.26.734850Cold Spring Harbor Laboratory2026-06-29
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Molecular mechanism of IF1- and IF2-driven translation initiation in bacteria
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https://www.biorxiv.org/content/10.64898/2026.06.26.734871v1?rss=1
2026-06-29doi:10.64898/2026.06.26.734871Cold Spring Harbor Laboratory2026-06-29
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Selective knockout of PKA regulatory subunits reveal opposite catalytic and metabolic consequences with implications for Alzheimer's disease
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https://www.biorxiv.org/content/10.64898/2026.06.26.734839v1?rss=1
2026-06-29doi:10.64898/2026.06.26.734839Cold Spring Harbor Laboratory2026-06-29
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Genetic Code Expansion for Site-Specific Encoding of a Switchable, Intrinsic Fluorophore-Quencher Pair to Monitor Protein Dynamics
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https://www.biorxiv.org/content/10.64898/2026.06.26.734876v1?rss=1
2026-06-29doi:10.64898/2026.06.26.734876Cold Spring Harbor Laboratory2026-06-29
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Lipid-Coated Water-in-Oil Droplets as a Passivation-Free Platform for Cost-Effective Fluorescence Spectroscopy
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https://www.biorxiv.org/content/10.64898/2026.06.26.734730v1?rss=1
2026-06-29doi:10.64898/2026.06.26.734730Cold Spring Harbor Laboratory2026-06-29
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Where do the ligands bind? Co-folding bitter taste GPCRs with the BitterDB chemical space
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https://www.biorxiv.org/content/10.64898/2026.06.26.734512v1?rss=1
2026-06-27doi:10.64898/2026.06.26.734512Cold Spring Harbor Laboratory2026-06-27
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Cryo-electron microscopy structure of the bovine ephemeral fever virus RNA-nucleoprotein assembly
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https://www.biorxiv.org/content/10.64898/2026.06.26.734764v1?rss=1
2026-06-27doi:10.64898/2026.06.26.734764Cold Spring Harbor Laboratory2026-06-27
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Systematic optimization and benchmarking of synchro-PASEF for high-throughput phosphoproteome profiling
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https://www.biorxiv.org/content/10.64898/2026.06.26.734570v1?rss=1
2026-06-27doi:10.64898/2026.06.26.734570Cold Spring Harbor Laboratory2026-06-27
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Depleting prion protein using splice-switching small molecules
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https://www.biorxiv.org/content/10.64898/2026.06.26.734742v1?rss=1
2026-06-27doi:10.64898/2026.06.26.734742Cold Spring Harbor Laboratory2026-06-27
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Quinone-transporting filaments extend the respiratory chain of Gram positive bacteria
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https://www.biorxiv.org/content/10.64898/2026.06.26.734721v1?rss=1
2026-06-27doi:10.64898/2026.06.26.734721Cold Spring Harbor Laboratory2026-06-27
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Electron confurcation drives photosynthetic H2 production in cyanobacteria
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https://www.biorxiv.org/content/10.64898/2026.06.25.734504v1?rss=1
2026-06-26doi:10.64898/2026.06.25.734504Cold Spring Harbor Laboratory2026-06-26
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Cardiolipin modulation of MmpL3 in mycobacteria
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https://www.biorxiv.org/content/10.64898/2026.06.25.734600v1?rss=1
2026-06-26doi:10.64898/2026.06.25.734600Cold Spring Harbor Laboratory2026-06-26
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Evolution of a core ribosomal innovation in octopus
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https://www.biorxiv.org/content/10.64898/2026.06.25.734654v1?rss=1
2026-06-26doi:10.64898/2026.06.25.734654Cold Spring Harbor Laboratory2026-06-26
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Expanding the methionine toolkit: L-cyanohomoalanine as a multifunctional analog
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https://www.biorxiv.org/content/10.64898/2026.06.25.734610v1?rss=1
2026-06-26doi:10.64898/2026.06.25.734610Cold Spring Harbor Laboratory2026-06-26
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Hydration and H/D exchange-dependent infrared signatures of the GCN4 leucine zipper
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https://www.biorxiv.org/content/10.64898/2026.06.26.731617v1?rss=1
2026-06-26doi:10.64898/2026.06.26.731617Cold Spring Harbor Laboratory2026-06-26
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Antiglycation effects of imidazole dipeptides and 2-oxo-imidazole dipeptides on glyceraldehyde-induced intracellular protein glycation and neuronal cell death
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https://www.biorxiv.org/content/10.64898/2026.06.25.734660v1?rss=1
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org.highwire.dtl.DTLVardef@16dc32aorg.highwire.dtl.DTLVardef@128273dorg.highwire.dtl.DTLVardef@1284ab3org.highwire.dtl.DTLVardef@406df6_HPS_FORMAT_FIGEXP M_FIG C_FIG
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Hot Pursuit: Bioinformatic and Biochemical Characterization of a Hyperthermophilic Family B DNA Polymerase from Pyrolobus fumarii A1
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https://www.biorxiv.org/content/10.64898/2026.06.25.734501v1?rss=1
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org.highwire.dtl.DTLVardef@ec2bd0org.highwire.dtl.DTLVardef@13082e8org.highwire.dtl.DTLVardef@1e28245org.highwire.dtl.DTLVardef@1d69164_HPS_FORMAT_FIGEXP M_FIG C_FIG
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Small-molecule inhibition of the Orientia tsutsugamushi deubiquitylating enzyme OtDUB impairs bacterial reproduction
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https://www.biorxiv.org/content/10.64898/2026.06.25.734012v1?rss=1
2026-06-26doi:10.64898/2026.06.25.734012Cold Spring Harbor Laboratory2026-06-26
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High-Throughput Screening Identifies Small-Molecule Inhibitors of the Tau-LRP1 Interaction
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https://www.biorxiv.org/content/10.64898/2026.06.24.733881v1?rss=1
2026-06-25doi:10.64898/2026.06.24.733881Cold Spring Harbor Laboratory2026-06-25
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Tracing the Path from 4-Hydroxyphenylpyruvate to the Benzoquinone Ring of Q6 and the p-aminobenzoate pathway in Yeast
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https://www.biorxiv.org/content/10.64898/2026.06.24.734323v1?rss=1
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org.highwire.dtl.DTLVardef@1982bddorg.highwire.dtl.DTLVardef@167f888org.highwire.dtl.DTLVardef@ede4eforg.highwire.dtl.DTLVardef@5146fc_HPS_FORMAT_FIGEXP M_FIG Graphical abstract.4-hydroxyphenylpyruvic acid (4HPP), 4-hydroxymandelate (4HMA), 4-hydroxybenzoic acid (4HB), p-aminobenzoic acid (pABA).
C_FIG
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Self-assembling nanoparticles to assess multivalent interactions between influenza A virus hemagglutinin and glycan surfaces
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https://www.biorxiv.org/content/10.64898/2026.06.24.734152v1?rss=1
2026-06-25doi:10.64898/2026.06.24.734152Cold Spring Harbor Laboratory2026-06-25
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Genetic Code Expansion, Enzymatic Modification, and C-Terminal Labeling Enable Facile Production of Highly Modified α-Synuclein
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https://www.biorxiv.org/content/10.64898/2026.06.24.734353v1?rss=1
2026-06-25doi:10.64898/2026.06.24.734353Cold Spring Harbor Laboratory2026-06-25
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PARP1 Exhibits an Enzymatically Inactive Chromatin Binding Mode
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https://www.biorxiv.org/content/10.64898/2026.06.24.734344v1?rss=1
2026-06-25doi:10.64898/2026.06.24.734344Cold Spring Harbor Laboratory2026-06-25
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Structural and Biochemical Analysis of the CABIT1 Domain of THEMIS
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https://www.biorxiv.org/content/10.64898/2026.06.24.734275v1?rss=1
2026-06-25doi:10.64898/2026.06.24.734275Cold Spring Harbor Laboratory2026-06-25
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Regulating Light-Harvesting Protein Assembly through Engineered Trimers of Phycocyanin and Allophycocyanin
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https://www.biorxiv.org/content/10.64898/2026.06.24.734401v1?rss=1
2026-06-25doi:10.64898/2026.06.24.734401Cold Spring Harbor Laboratory2026-06-25