bioRxiv Subject Collection: Biochemistry
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This feed contains articles for bioRxiv Subject Collection "Biochemistry"
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Molecular architecture of meiotic pro-crossover factor HEI10 reveals coupling of higher-order assembly and ubiquitin chain formation
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https://www.biorxiv.org/content/10.64898/2026.05.08.723602v1?rss=1
2026-05-10doi:10.64898/2026.05.08.723602Cold Spring Harbor Laboratory2026-05-10
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Molecular basis for the role of Ripr in Plasmodium falciparum invasion of human erythrocytes
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https://www.biorxiv.org/content/10.64898/2026.05.07.723680v1?rss=1
2026-05-09doi:10.64898/2026.05.07.723680Cold Spring Harbor Laboratory2026-05-09
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A Phosphorylation Switch Modulates Configurational Codes in the Oncofetal IGF2BP RNA Binding Paralogs
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https://www.biorxiv.org/content/10.64898/2026.05.07.723538v1?rss=1
70% sequence identity. These paralog specific, phosphorylation dependent configurational landscapes likely underlie differences in mRNA recognition modes and functional outcomes. Our work identifies a post translational mechanism that tunes IGF2BP paralog dynamics across free and RNA bound states to program target mRNA selection, processing, and translational fate.
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Localized heme sensing through a ternary molecular glue
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https://www.biorxiv.org/content/10.64898/2026.05.07.723605v1?rss=1
2026-05-08doi:10.64898/2026.05.07.723605Cold Spring Harbor Laboratory2026-05-08
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A de novo CO2 Reductase Featuring a Cysteine-Ligated Cobalt Porphyrin Cofactor
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https://www.biorxiv.org/content/10.64898/2026.05.07.723500v1?rss=1
1000 turnovers at rates of up to 25 min-1) while suppressing competing hydrogen evolution pathways. A 2.1 [A] crystal structure shows close agreement to the design model with the Co-Cys bond programmed as intended. This study showcases the power of computational protein design in developing artificial enzymes to activate challenging molecules such as CO2.
]]>2026-05-08doi:10.64898/2026.05.07.723500Cold Spring Harbor Laboratory2026-05-08
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Elucidation of the anti-inflammatory mechanism of isoliquiritigenin from Glycyrrhiza uralensis using activity-based protein profiling
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https://www.biorxiv.org/content/10.64898/2026.05.05.722967v1?rss=1
2026-05-08doi:10.64898/2026.05.05.722967Cold Spring Harbor Laboratory2026-05-08
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The development of ToF-SIMS for in-situ glycosaminoglycan analysis
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https://www.biorxiv.org/content/10.64898/2026.05.06.723150v1?rss=1
2026-05-08doi:10.64898/2026.05.06.723150Cold Spring Harbor Laboratory2026-05-08
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More than an attachment module: covalent inhibitor warheads influence BTK dynamics and function.
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https://www.biorxiv.org/content/10.64898/2026.05.07.723540v1?rss=1
2026-05-08doi:10.64898/2026.05.07.723540Cold Spring Harbor Laboratory2026-05-08
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Hydrophobic pocket engineering of arylmalonate decarboxylase expands its substrate scope towards the synthesis of the (R)-enantiomers of sterically hindered carboxylic acids
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https://www.biorxiv.org/content/10.64898/2026.05.07.723505v1?rss=1
2026-05-08doi:10.64898/2026.05.07.723505Cold Spring Harbor Laboratory2026-05-08
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Ethanol-assisted core-shell microparticles for enzyme stabilization with precise size control
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https://www.biorxiv.org/content/10.64898/2026.05.05.722948v1?rss=1
2026-05-08doi:10.64898/2026.05.05.722948Cold Spring Harbor Laboratory2026-05-08
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Schizokinen siderophores in the methylotrophy model organism Methylorubrum extorquens AM1
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https://www.biorxiv.org/content/10.64898/2026.05.05.723055v1?rss=1
2026-05-08doi:10.64898/2026.05.05.723055Cold Spring Harbor Laboratory2026-05-08
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Rhodopsin is a tunable capacitor buffering the toxic, desensitizing retinoids of the vertebrate eye
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https://www.biorxiv.org/content/10.64898/2026.05.05.722510v1?rss=1
2026-05-08doi:10.64898/2026.05.05.722510Cold Spring Harbor Laboratory2026-05-08
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Thermal-Acoustic Activation of Hydrophobic Polystyrene Supports for High-Efficiency Aqueous Solid-Phase Peptide Synthesis
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https://www.biorxiv.org/content/10.64898/2026.05.05.722603v1?rss=1
2026-05-08doi:10.64898/2026.05.05.722603Cold Spring Harbor Laboratory2026-05-08
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Multi-Substrate Specificity of Isoflavone hydroxylases (GmIFH) Drive Isoflavonoid Diversification in Soybean
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https://www.biorxiv.org/content/10.64898/2026.05.05.722824v1?rss=1
2026-05-08doi:10.64898/2026.05.05.722824Cold Spring Harbor Laboratory2026-05-08
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LonP1 chaperone-like activity is ATPase independent and is mediated by its N-domain
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https://www.biorxiv.org/content/10.64898/2026.05.06.723147v1?rss=1
2026-05-08doi:10.64898/2026.05.06.723147Cold Spring Harbor Laboratory2026-05-08
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Bisphenol-A mediated ubiquitinome alteration triggers PPAR-alpha ubiquitination, affecting trophoblast cell migration
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https://www.biorxiv.org/content/10.64898/2026.05.07.723151v1?rss=1
2026-05-08doi:10.64898/2026.05.07.723151Cold Spring Harbor Laboratory2026-05-08
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A CYFIP1-Inspired Peptidomimetic Modulates eIF4E-Dependent Translational Control in Cancer and Neurodevelopmental Disorders
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https://www.biorxiv.org/content/10.64898/2026.05.06.722988v1?rss=1
2026-05-08doi:10.64898/2026.05.06.722988Cold Spring Harbor Laboratory2026-05-08
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Local aromatic interactions define temperature sensitivity of phase separation in an intrinsically disordered protein.
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https://www.biorxiv.org/content/10.64898/2026.05.07.723405v1?rss=1
2026-05-08doi:10.64898/2026.05.07.723405Cold Spring Harbor Laboratory2026-05-08
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Assessing State-Specific Accuracy of Cofolding Models for Kinases and GPCRs
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https://www.biorxiv.org/content/10.64898/2026.05.06.723350v1?rss=1
2026-05-08doi:10.64898/2026.05.06.723350Cold Spring Harbor Laboratory2026-05-08
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Systematic Characterization of Thermal Stability Assay Parameters and Application in Discovery of Peptide-Protein Interactions
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https://www.biorxiv.org/content/10.64898/2026.05.06.723354v1?rss=1
2026-05-08doi:10.64898/2026.05.06.723354Cold Spring Harbor Laboratory2026-05-08
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Stable isotope-assisted computational mass spectrometry reveals root-specific alkaloids in Glycyrrhiza species
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https://www.biorxiv.org/content/10.64898/2026.05.05.722977v1?rss=1
2026-05-08doi:10.64898/2026.05.05.722977Cold Spring Harbor Laboratory2026-05-08
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Identification of the siderophore schizokinen and its derivatives by LCHRMS and mass-tandem fragmentation
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https://www.biorxiv.org/content/10.64898/2026.05.05.723046v1?rss=1
2026-05-08doi:10.64898/2026.05.05.723046Cold Spring Harbor Laboratory2026-05-08
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The turn less taken: Investigating patterns in β-turn dynamics using large-scale molecular dynamics data
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https://www.biorxiv.org/content/10.64898/2026.05.07.721674v1?rss=1
2026-05-08doi:10.64898/2026.05.07.721674Cold Spring Harbor Laboratory2026-05-08
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Evolution of Protein Regulation in the Vertebrate Glucose Sensor
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https://www.biorxiv.org/content/10.64898/2026.05.05.723016v1?rss=1
2026-05-07doi:10.64898/2026.05.05.723016Cold Spring Harbor Laboratory2026-05-07
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Glycosylation-dependent Turnover of Triterpenoid Saponins Controls Insect Deterrence
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https://www.biorxiv.org/content/10.64898/2026.05.04.721528v1?rss=1
2026-05-07doi:10.64898/2026.05.04.721528Cold Spring Harbor Laboratory2026-05-07
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A method to synthesize analytical rhodoquinone standards for quantitative analysis in tissue specimen
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https://www.biorxiv.org/content/10.64898/2026.05.04.722805v1?rss=1
2026-05-07doi:10.64898/2026.05.04.722805Cold Spring Harbor Laboratory2026-05-07
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DNA supercoiling modulates bZIP transcription factor/DNA interaction
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https://www.biorxiv.org/content/10.64898/2026.05.06.722604v1?rss=1
2026-05-07doi:10.64898/2026.05.06.722604Cold Spring Harbor Laboratory2026-05-07
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Leiomodin 2 functions as a processive pointed-end elongator of actin filaments
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https://www.biorxiv.org/content/10.64898/2026.05.04.720848v1?rss=1
2026-05-07doi:10.64898/2026.05.04.720848Cold Spring Harbor Laboratory2026-05-07
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A lipid-binding protein in black-legged tick saliva selectively recognizes Borrelia burgdorferi lipids
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https://www.biorxiv.org/content/10.64898/2026.05.04.722819v1?rss=1
2026-05-07doi:10.64898/2026.05.04.722819Cold Spring Harbor Laboratory2026-05-07
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Transposon end recognition and excision mechanisms of type I-F CRISPR-associated transposases
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https://www.biorxiv.org/content/10.64898/2026.05.05.722991v1?rss=1
2026-05-07doi:10.64898/2026.05.05.722991Cold Spring Harbor Laboratory2026-05-07