bioRxiv Subject Collection: Biochemistry
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This feed contains articles for bioRxiv Subject Collection "Biochemistry"
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ARMH3 acts as a central scaffold at the Golgi/TGN through interactions with Arl5, GBF1, and PI4KB
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https://www.biorxiv.org/content/10.64898/2026.04.15.718671v1?rss=1
2026-04-17doi:10.64898/2026.04.15.718671Cold Spring Harbor Laboratory2026-04-17
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Native entanglement misfolding contributes to age-associated structural changes across the Saccharomyces cerevisiae proteome
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https://www.biorxiv.org/content/10.64898/2026.04.15.717356v1?rss=1
2026-04-17doi:10.64898/2026.04.15.717356Cold Spring Harbor Laboratory2026-04-17
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The Effects of Phosphorylation on the Structure and Function of Motif A, an Intrinsically Disordered Region within SIRT1
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https://www.biorxiv.org/content/10.64898/2026.04.16.718858v1?rss=1
2026-04-17doi:10.64898/2026.04.16.718858Cold Spring Harbor Laboratory2026-04-17
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Integrated bioinformatics and single-cell analysis identifies vascular aging-related hub genes and immune drivers in atherosclerosis.
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https://www.biorxiv.org/content/10.64898/2026.04.14.718580v1?rss=1
0.7), with TNF exhibiting superior performance. Immune infiltration analysis revealed profound alterations in 28 immune cell types, particularly monocytes and T cells, which correlated strongly with hub gene expression. Furthermore, single-cell RNA sequencing analysis (GSE184073) localized the expression of core genes predominantly to monocytes and T cells, highlighting TNF overexpression in T cells as a potential critical driver. Finally, molecular docking simulations suggested that curcumin exhibits strong binding affinity to these hub genes, particularly PPARG, providing a mechanistic basis for its therapeutic potential. Collectively, this study elucidates the landscape of vascular aging-related genes in AS, identifies novel diagnostic biomarkers, and proposes potential therapeutic targets involving immune modulation and natural compounds.
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A new stress-response pathway in Mycobacterium tuberculosis
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https://www.biorxiv.org/content/10.64898/2026.04.15.718621v1?rss=1
2026-04-16doi:10.64898/2026.04.15.718621Cold Spring Harbor Laboratory2026-04-16
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Acyl-enzyme dynamics, tautomerisation and hydration regulate turnover of carbapenem antibiotics by the OXA-48 β-lactamase
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https://www.biorxiv.org/content/10.64898/2026.04.15.718664v1?rss=1
2026-04-16doi:10.64898/2026.04.15.718664Cold Spring Harbor Laboratory2026-04-16
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Cephalopod Genome Expansion Drives Broader Reflectin Domain Boundaries
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https://www.biorxiv.org/content/10.64898/2026.04.14.718489v1?rss=1
2026-04-16doi:10.64898/2026.04.14.718489Cold Spring Harbor Laboratory2026-04-16
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Structural basis of chaperone mechanisms in cells and the evolutionary emergence of the protein world
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https://www.biorxiv.org/content/10.64898/2026.04.15.718697v1?rss=1
2026-04-16doi:10.64898/2026.04.15.718697Cold Spring Harbor Laboratory2026-04-16
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Cooperative Control of Arrestin Activation By Membrane Lipids And Phosphorylation Barcodes
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https://www.biorxiv.org/content/10.64898/2026.04.13.718317v1?rss=1
2026-04-16doi:10.64898/2026.04.13.718317Cold Spring Harbor Laboratory2026-04-16
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Photoacoustic Fingerprinting for Robust Molecular Imaging
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https://www.biorxiv.org/content/10.64898/2026.04.13.718141v1?rss=1
2026-04-15doi:10.64898/2026.04.13.718141Cold Spring Harbor Laboratory2026-04-15
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Molecular Architecture of Cryptococcus Cell Walls Reveals Species-Specific Chitosan-Dependent Remodeling
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https://www.biorxiv.org/content/10.64898/2026.04.14.718415v1?rss=1
2026-04-15doi:10.64898/2026.04.14.718415Cold Spring Harbor Laboratory2026-04-15
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ChemCell: Chemical Tethering of Large Biomolecules to Cell Surfaces through Diels-Alder Ligation
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https://www.biorxiv.org/content/10.64898/2026.04.13.718024v1?rss=1
2026-04-15doi:10.64898/2026.04.13.718024Cold Spring Harbor Laboratory2026-04-15
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A miniaturized MR1 metabolite display system with native-like protein features
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https://www.biorxiv.org/content/10.64898/2026.04.13.718121v1?rss=1
2026-04-15doi:10.64898/2026.04.13.718121Cold Spring Harbor Laboratory2026-04-15
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Dietary Oxysterols Reprogram Hepatic Lipid Metabolism and Reshape the Gut Metabolome-Microbiome Interface
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https://www.biorxiv.org/content/10.64898/2026.04.12.717948v1?rss=1
2026-04-14doi:10.64898/2026.04.12.717948Cold Spring Harbor Laboratory2026-04-14
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Small Molecule Regulation of CLOCK:BMAL1 DNA Binding Activity
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https://www.biorxiv.org/content/10.64898/2026.04.13.718289v1?rss=1
2026-04-14doi:10.64898/2026.04.13.718289Cold Spring Harbor Laboratory2026-04-14
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Multiscale Physical Effects of CpG Methylation on DNA Mechanics, Nucleosome Wrapping, and Chromatin Condensates
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https://www.biorxiv.org/content/10.64898/2026.04.13.715649v1?rss=1
2026-04-14doi:10.64898/2026.04.13.715649Cold Spring Harbor Laboratory2026-04-14
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Investigating the Consequences of Non-active site Mutations on the Structure, Function and Dynamics of the Molten Globule Enzyme Monomeric Chorismate Mutase
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https://www.biorxiv.org/content/10.64898/2026.04.11.717874v1?rss=1
2026-04-14doi:10.64898/2026.04.11.717874Cold Spring Harbor Laboratory2026-04-14
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Coupling of electron-bifurcation modules powers aromatic ring reduction beyond the biological redox window
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https://www.biorxiv.org/content/10.64898/2026.04.10.717634v1?rss=1
2026-04-13doi:10.64898/2026.04.10.717634Cold Spring Harbor Laboratory2026-04-13
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Saliva Metabolomics Reveals Distinct Metabolic Signatures in Patients with Chronic Obstructive Pulmonary Disease: A GC-MS-based approach.
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https://www.biorxiv.org/content/10.64898/2026.04.10.717654v1?rss=1
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Immobilized enzyme-assisted production of recombinant P113 peptide
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https://www.biorxiv.org/content/10.64898/2026.04.11.717888v1?rss=1
2026-04-13doi:10.64898/2026.04.11.717888Cold Spring Harbor Laboratory2026-04-13
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Detergent-Free Nuclear-Cytoplasmic Fractionation Enables Spatially Resolved PELSA for Enhanced Nuclear Drug Target Identification
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https://www.biorxiv.org/content/10.64898/2026.04.10.717665v1?rss=1
2026-04-13doi:10.64898/2026.04.10.717665Cold Spring Harbor Laboratory2026-04-13
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Crystal structure and molecular dynamics simulations of rademikibart Fab-IL-4Rα complex reveal biochemical basis for next-generation potent IL-4Rα inhibition in type 2 allergic and inflammatory diseases
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https://www.biorxiv.org/content/10.64898/2026.04.12.718052v1?rss=1
2026-04-13doi:10.64898/2026.04.12.718052Cold Spring Harbor Laboratory2026-04-13
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A novel sample delivery method for powder X-ray diffraction at Turkish Light Source
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https://www.biorxiv.org/content/10.64898/2026.04.09.717569v1?rss=1
2026-04-13doi:10.64898/2026.04.09.717569Cold Spring Harbor Laboratory2026-04-13
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SLFN-generated 3'-truncated tRNALeu or tRNASer together with tRNase ZL works as a sequence-specific RNA cutter
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https://www.biorxiv.org/content/10.64898/2026.04.12.718003v1?rss=1
2026-04-13doi:10.64898/2026.04.12.718003Cold Spring Harbor Laboratory2026-04-13
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A Multi-Objective Scoring (MOS) Framework for Detecting Cross-Modal Spatial Similarity: Conceptual and Direct Formulations
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https://www.biorxiv.org/content/10.64898/2026.04.09.717471v1?rss=1
2026-04-13doi:10.64898/2026.04.09.717471Cold Spring Harbor Laboratory2026-04-13
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Phosphorylation of UBE2J1 at serine residue S184 contributes towards infection and cellular syncytialization by Vesicular Stomatitis Virus
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https://www.biorxiv.org/content/10.64898/2026.04.12.717905v1?rss=1
2026-04-12doi:10.64898/2026.04.12.717905Cold Spring Harbor Laboratory2026-04-12
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Mechanism of GPR84 allosteric modulation at a helix 8-proximate site
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https://www.biorxiv.org/content/10.64898/2026.04.10.715585v1?rss=1
2026-04-12doi:10.64898/2026.04.10.715585Cold Spring Harbor Laboratory2026-04-12
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Beyond the surface: plasmalogens are dispensable for retinal integrity and fertility in the mouse
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https://www.biorxiv.org/content/10.64898/2026.04.09.717382v1?rss=1
2026-04-12doi:10.64898/2026.04.09.717382Cold Spring Harbor Laboratory2026-04-12
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Molecular dissection of protein complexes isolated from sections of human brain
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https://www.biorxiv.org/content/10.64898/2026.04.11.717886v1?rss=1
2026-04-12doi:10.64898/2026.04.11.717886Cold Spring Harbor Laboratory2026-04-12
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Proteomics-Based Discovery of Symmetry-Specific Readers and Antireaders of 5-Formylcytosine in Mammalian DNA
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https://www.biorxiv.org/content/10.64898/2026.04.09.717454v1?rss=1
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