bioRxiv Subject Collection: All
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Bayesian adaptive experimental design for efficient microbial genome-wide association studies
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https://www.biorxiv.org/content/10.64898/2026.08.26.747358v1?rss=1
2026-08-31doi:10.64898/2026.08.26.747358Cold Spring Harbor Laboratory2026-08-31
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Simvastatin attenuates disease phenotypes in human induced pluripotent stem cell models of familial Parkinson's disease through RhoA inhibition
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https://www.biorxiv.org/content/10.64898/2026.08.26.747232v1?rss=1
2026-08-31doi:10.64898/2026.08.26.747232Cold Spring Harbor Laboratory2026-08-31
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Ratiometric growth-rate control enables robust coexistence in competing microbial consortia
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https://www.biorxiv.org/content/10.64898/2026.08.28.747825v1?rss=1
2026-08-31doi:10.64898/2026.08.28.747825Cold Spring Harbor Laboratory2026-08-31
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Shape Analysis of Coronary Flow Waveforms using Singular Value Decomposition
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https://www.biorxiv.org/content/10.64898/2026.08.26.743980v1?rss=1
2026-08-31doi:10.64898/2026.08.26.743980Cold Spring Harbor Laboratory2026-08-31
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Structure of an RNA polymerase ribozyme replication complex
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https://www.biorxiv.org/content/10.64898/2026.08.30.748161v1?rss=1
2026-08-31doi:10.64898/2026.08.30.748161Cold Spring Harbor Laboratory2026-08-31
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Network-based meta-analysis maps stage-dependent molecular programs in MASLD through MASLD-META NETWORK application
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https://www.biorxiv.org/content/10.64898/2026.08.26.747338v1?rss=1
2026-08-31doi:10.64898/2026.08.26.747338Cold Spring Harbor Laboratory2026-08-31
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MetaDome 2027: a comprehensively updated resource for aggregating missense variant evidence across homologous human protein domains
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https://www.biorxiv.org/content/10.64898/2026.08.26.747388v1?rss=1
2026-08-31doi:10.64898/2026.08.26.747388Cold Spring Harbor Laboratory2026-08-31
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Every Cure Knowledge Graph: A Unified Biomedical Knowledge Graph for Drug Repurposing
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https://www.biorxiv.org/content/10.64898/2026.08.26.747253v1?rss=1
2026-08-31doi:10.64898/2026.08.26.747253Cold Spring Harbor Laboratory2026-08-31
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The evolutionarily conserved C-terminal domain of a domesticated transposase-derived protein regulates its DNA integration ability
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https://www.biorxiv.org/content/10.64898/2026.08.31.747927v1?rss=1
2026-08-31doi:10.64898/2026.08.31.747927Cold Spring Harbor Laboratory2026-08-31
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Higher rewards lead to more accurate flower detection and increased contrast sensitivity in the bumblebee Bombus terrestris
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https://www.biorxiv.org/content/10.64898/2026.08.26.747241v1?rss=1
2026-08-31doi:10.64898/2026.08.26.747241Cold Spring Harbor Laboratory2026-08-31
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Temporal, genome-scale analysis of Myxococcus xanthus developmental fate in a mixed population
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https://www.biorxiv.org/content/10.64898/2026.08.28.747804v1?rss=1
2026-08-31doi:10.64898/2026.08.28.747804Cold Spring Harbor Laboratory2026-08-31
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Genome-scale label-free imaging reveals cellular physiology encoded in bacterial collective architecture
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https://www.biorxiv.org/content/10.64898/2026.08.30.748126v1?rss=1
2026-08-31doi:10.64898/2026.08.30.748126Cold Spring Harbor Laboratory2026-08-31
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Soil Microbial and Biochemical Properties under Conservation Agriculture in rice-based cropping systems in lower Indo-Gangetic Plain of West Bengal
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https://www.biorxiv.org/content/10.64898/2026.08.31.748290v1?rss=1
2026-08-31doi:10.64898/2026.08.31.748290Cold Spring Harbor Laboratory2026-08-31
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Contrasting evolutionary trajectories of nitrate assimilation across Brettanomyces bruxellensis lineages
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https://www.biorxiv.org/content/10.64898/2026.08.31.748220v1?rss=1
2026-08-31doi:10.64898/2026.08.31.748220Cold Spring Harbor Laboratory2026-08-31
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Rapid isothermal amplification of diatom rbcL from eDNA and eRNA reveals their abundance and photosynthetic physiology
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https://www.biorxiv.org/content/10.64898/2026.08.30.748096v1?rss=1
2026-08-31doi:10.64898/2026.08.30.748096Cold Spring Harbor Laboratory2026-08-31
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RNA virus infection reshapes carbon and nitrogen partitioning in a marine diatom.
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https://www.biorxiv.org/content/10.64898/2026.08.30.748135v1?rss=1
2026-08-31doi:10.64898/2026.08.30.748135Cold Spring Harbor Laboratory2026-08-31
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Defining the role of aerobic respiration in the metabolism and bioenergetics of Enterococcus faecalis
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https://www.biorxiv.org/content/10.64898/2026.08.30.748090v1?rss=1
2026-08-31doi:10.64898/2026.08.30.748090Cold Spring Harbor Laboratory2026-08-31
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Effect of Mushroom-Bacteria Co-culture on Mushroom Growth and Antimicrobial Properties
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https://www.biorxiv.org/content/10.64898/2026.08.30.747672v1?rss=1
2026-08-31doi:10.64898/2026.08.30.747672Cold Spring Harbor Laboratory2026-08-31
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Receptor-binding domain 2 of Clostridioides difficile binary toxin as a promising vaccine component against C. difficile infection
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https://www.biorxiv.org/content/10.64898/2026.08.30.748174v1?rss=1
2026-08-31doi:10.64898/2026.08.30.748174Cold Spring Harbor Laboratory2026-08-31
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Osmotic adaptation rather than stress response: A time-resolved proteomic analysis of PEG-induced water limitation in Phytophthora cinnamomi
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https://www.biorxiv.org/content/10.64898/2026.08.30.747438v1?rss=1
2026-08-31doi:10.64898/2026.08.30.747438Cold Spring Harbor Laboratory2026-08-31
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Differential Biofilm Susceptibility and Potent Isavuconazole Post-Antifungal Effect Distinguish Cutaneotrichosporon dermatis from Trichosporon asahii
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https://www.biorxiv.org/content/10.64898/2026.08.30.748177v1?rss=1
2026-08-31doi:10.64898/2026.08.30.748177Cold Spring Harbor Laboratory2026-08-31
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The RNA virome of early metazoans sheds light on long-term virus-host relationships
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https://www.biorxiv.org/content/10.64898/2026.08.30.748148v1?rss=1
2026-08-31doi:10.64898/2026.08.30.748148Cold Spring Harbor Laboratory2026-08-31
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Design and characterization of broadly protective influenza A(H3N2) vaccine candidates using protein language models
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https://www.biorxiv.org/content/10.64898/2026.08.26.747087v1?rss=1
2026-08-31doi:10.64898/2026.08.26.747087Cold Spring Harbor Laboratory2026-08-31
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Maturation-dependent splicing alterations constrain SYNGAP1 splice-switching therapy
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https://www.biorxiv.org/content/10.64898/2026.08.26.745682v1?rss=1
2026-08-31doi:10.64898/2026.08.26.745682Cold Spring Harbor Laboratory2026-08-31
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Early MATR3 loss and distinct neurodegenerative molecular signatures precede the onset of neuropathology in motor neurons and Purkinje cells of MATR3 S85C knock-in mouse model of ALS
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https://www.biorxiv.org/content/10.64898/2026.08.26.747343v1?rss=1
2026-08-31doi:10.64898/2026.08.26.747343Cold Spring Harbor Laboratory2026-08-31
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A neuronal CRISPRi screen identifies PQLC2 as a lysosomal pH regulator controlling tau homeostasis
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https://www.biorxiv.org/content/10.64898/2026.08.25.747102v1?rss=1
2026-08-31doi:10.64898/2026.08.25.747102Cold Spring Harbor Laboratory2026-08-31
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Learning a threat converges on the circuit processing innate threat
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https://www.biorxiv.org/content/10.64898/2026.08.26.747219v1?rss=1
2026-08-31doi:10.64898/2026.08.26.747219Cold Spring Harbor Laboratory2026-08-31
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Glioblastoma Tumors with Decelerated Epigenetic Aging Are Characterized by Glutamatergic Neuronal Activity and Stemness
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https://www.biorxiv.org/content/10.64898/2026.08.29.747960v1?rss=1
2026-08-31doi:10.64898/2026.08.29.747960Cold Spring Harbor Laboratory2026-08-31
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Pan-cancer analysis identifies nine conserved miRNA regulators of tumor cytolytic activity and clinically actionable immune targets
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https://www.biorxiv.org/content/10.64898/2026.08.30.748071v1?rss=1
= 0.30, FDR < 0.05) identified recurrent CYT-associated miRNAs (at least 3 cancer types); these were integrated with TargetScan-predicted targets and subjected to pan-cancer and cross-cancer triple filtering (miRNA-gene and gene-CYT associations). All associations underwent tumor purity adjustment using Consensus Purity Estimate (CPE), with LUMP (Leukocytes Unmethylation for Purity) as sensitivity analysis. Candidates were further prioritized by random forest modeling with bootstrap stability, cancer-type-adjusted Cox regression, mediation analysis, immune cell deconvolution, k-means molecular subtyping, pathway enrichment, and DGIdb-based drug-target prioritization. Results: The analysis converged on 38 high-confidence miRNA-gene-CYT regulatory triplets involving 9 conserved miRNAs and 31 target genes after stringent purity adjustment and multi-layer validation. All nine miRNAs exhibited complete bootstrap stability. Mediation analysis confirmed significant gene-level mediation in 37 of 38 triplets (FDR < 0.01), with mediated proportions up to 94%. The final miRNA signature defined two distinct pan-cancer immune subtypes (immune-hot vs. immune-cold) with significantly different cytolytic activity and overall survival (OS) (HR = 0.754, FDR = 1.12 x 10^-4). The network was enriched for T-cell activation and lymphocyte differentiation pathways and highlighted multiple druggable targets, including CTLA4 and CD274 (PD-L1), nominating 124 candidate compounds. Conclusions: In conclusion, this tumor purity-adjusted pan-cancer study defines a compact, reproducible, and clinically relevant miRNA network that regulates cytolytic activity across diverse malignancies. By linking miRNA biology to immune subtyping and actionable therapeutic targets, the present work provides a valuable foundation for advancing precision immuno-oncology.
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Cryo-EM structure of CYP2C9 reveals a dimer-of-trimers assembly
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https://www.biorxiv.org/content/10.64898/2026.08.30.747968v1?rss=1
2026-08-31doi:10.64898/2026.08.30.747968Cold Spring Harbor Laboratory2026-08-31