bioRxiv Subject Collection: Pharmacology And Toxicology
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This feed contains articles for bioRxiv Subject Collection "Pharmacology And Toxicology"
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The D2-mdx mouse as a preclinical model for Duchenne muscular dystrophy: a natural history study across two independent sites
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https://www.biorxiv.org/content/10.64898/2026.07.08.737223v1?rss=1
2026-07-12doi:10.64898/2026.07.08.737223Cold Spring Harbor Laboratory2026-07-12
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Cytotoxicity of Pelargonic Acid and Its Commercial Formulation Roundup NL (Glyphosate-Free Roundup)
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https://www.biorxiv.org/content/10.64898/2026.07.07.736979v1?rss=1
2026-07-11doi:10.64898/2026.07.07.736979Cold Spring Harbor Laboratory2026-07-11
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Voclosporin Preserves Mitochondrial Function Compared With Cyclosporine A in Perfused Human Proximal Tubule Microphysiological Systems
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https://www.biorxiv.org/content/10.64898/2026.07.07.737071v1?rss=1
2026-07-11doi:10.64898/2026.07.07.737071Cold Spring Harbor Laboratory2026-07-11
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Modulation of NF-κB signaling by Alternaria mycotoxins: in vitro and in silico insights into molecular mechanisms of immunosuppression in THP-1 monocytes
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https://www.biorxiv.org/content/10.64898/2026.07.06.736814v1?rss=1
2026-07-09doi:10.64898/2026.07.06.736814Cold Spring Harbor Laboratory2026-07-09
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Mechanistic characterization of tenuazonic acid-induced cellular stress responses in human esophageal KYSE-510 cells
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https://www.biorxiv.org/content/10.64898/2026.07.06.736731v1?rss=1
2026-07-09doi:10.64898/2026.07.06.736731Cold Spring Harbor Laboratory2026-07-09
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DSPE-PEG does not retain targeting antibodies on LNP surfaces in vivo; a higher molecular weight anchor is required
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https://www.biorxiv.org/content/10.64898/2026.07.02.736109v1?rss=1
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Environmentally relevant depleted uranium exposure damages mitochondria, decreases cytosolic reductive capacity, and increases global DNA damage accumulation through a ROS-independent mechanism involving slingshot protein phosphatase 1b enrichment.
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https://www.biorxiv.org/content/10.64898/2026.07.02.736169v1?rss=1
2026-07-08doi:10.64898/2026.07.02.736169Cold Spring Harbor Laboratory2026-07-08
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Ocimum gratissimum essential oil nanoemulsions as a safe topical nanoplatform for antibacterial and wound-healing activities
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https://www.biorxiv.org/content/10.64898/2026.07.01.735794v1?rss=1
2026-07-07doi:10.64898/2026.07.01.735794Cold Spring Harbor Laboratory2026-07-07
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Green-synthesized silver nanoparticles enhance Guibourtia tessmannii antithromboinflammatory therapeutic potential
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https://www.biorxiv.org/content/10.64898/2026.07.03.736249v1?rss=1
2026-07-06doi:10.64898/2026.07.03.736249Cold Spring Harbor Laboratory2026-07-06
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Suprachoroidal Delivery of Anti-Angiogenic Peptide Microparticles Enables Sustained Activity with Favorable Ocular Safety
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https://www.biorxiv.org/content/10.64898/2026.06.30.735614v1?rss=1
2026-07-05doi:10.64898/2026.06.30.735614Cold Spring Harbor Laboratory2026-07-05
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Novel apoptosis signal-regulating kinase 1 (ASK1) inhibitor SRT-015: Potential therapeutic for multiple liver diseases
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https://www.biorxiv.org/content/10.64898/2026.06.30.735673v1?rss=1
2026-07-05doi:10.64898/2026.06.30.735673Cold Spring Harbor Laboratory2026-07-05
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β-alanine betaine and nAChRs in Ascaris
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https://www.biorxiv.org/content/10.64898/2026.06.30.735465v1?rss=1
2026-07-03doi:10.64898/2026.06.30.735465Cold Spring Harbor Laboratory2026-07-03
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Adenosine A2B Receptor Activation: A Novel Therapeutic Strategy for Accelerating Liver Recovery After Acetaminophen Overdose
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https://www.biorxiv.org/content/10.64898/2026.06.29.735109v1?rss=1
2026-07-03doi:10.64898/2026.06.29.735109Cold Spring Harbor Laboratory2026-07-03
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Evaluation of Retinal Safety of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors
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https://www.biorxiv.org/content/10.64898/2026.06.29.735161v1?rss=1
2026-07-02doi:10.64898/2026.06.29.735161Cold Spring Harbor Laboratory2026-07-02
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The effects of estrogen exposure on survival, growth, and fecundity of Daphnia magna
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https://www.biorxiv.org/content/10.64898/2026.06.27.734946v1?rss=1
2026-07-02doi:10.64898/2026.06.27.734946Cold Spring Harbor Laboratory2026-07-02
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Computational Design of Two Novel BRAF V600E Inhibitors: Exploiting Sulfoximine Bioisosterism and Chiral Constraints to Evade Paradoxical Activation
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https://www.biorxiv.org/content/10.64898/2026.06.25.734343v1?rss=1
2026-06-30doi:10.64898/2026.06.25.734343Cold Spring Harbor Laboratory2026-06-30
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Proteomic profiling of xenobiotic and nutrient transporters in human placenta of different gestational ages
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https://www.biorxiv.org/content/10.64898/2026.06.25.730994v1?rss=1
2026-06-30doi:10.64898/2026.06.25.730994Cold Spring Harbor Laboratory2026-06-30
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Basal Internalization and Subcellular Localization of XCR1
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https://www.biorxiv.org/content/10.64898/2026.06.25.734240v1?rss=1
2026-06-30doi:10.64898/2026.06.25.734240Cold Spring Harbor Laboratory2026-06-30
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Synapse-based bispecific immune cell engager model predicts invariance in synapse behavior across different effector-to-tumor cell ratios
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https://www.biorxiv.org/content/10.64898/2026.06.24.733437v1?rss=1
2026-06-29doi:10.64898/2026.06.24.733437Cold Spring Harbor Laboratory2026-06-29
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Enhanced TRPV1 activation through TLR-4 and PKA signaling in Dorsal Root Ganglia Neurons
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https://www.biorxiv.org/content/10.64898/2026.06.24.734307v1?rss=1
2026-06-29doi:10.64898/2026.06.24.734307Cold Spring Harbor Laboratory2026-06-29
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Opposing immunomodulatory effects of the Alternaria mycotoxin tenuazonic acid in immune and intestinal epithelial cells
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https://www.biorxiv.org/content/10.64898/2026.06.24.734282v1?rss=1
2026-06-29doi:10.64898/2026.06.24.734282Cold Spring Harbor Laboratory2026-06-29
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Fructooligosaccharide Supplementation Improves Glucose Homeostasis in Human-Relevant hyperglycemic Diet-Induced Obese Mice
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https://www.biorxiv.org/content/10.64898/2026.06.23.733678v1?rss=1
2026-06-29doi:10.64898/2026.06.23.733678Cold Spring Harbor Laboratory2026-06-29
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A Protease-Cleavable iNOS-Inhibitor Polymeric Prodrug Designed for Controlled Modulation of Nitric Oxide
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https://www.biorxiv.org/content/10.64898/2026.06.23.733308v1?rss=1
2026-06-29doi:10.64898/2026.06.23.733308Cold Spring Harbor Laboratory2026-06-29
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Dose optimisation of favipiravir against RNA viruses using physiologically-based pharmacokinetic modelling.
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https://www.biorxiv.org/content/10.64898/2026.06.24.733995v1?rss=1
2026-06-26doi:10.64898/2026.06.24.733995Cold Spring Harbor Laboratory2026-06-26
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A Designed Ankyrin Repeat Protein (DARPin) Targeting EGFR Inhibits Ovulation and Enables a Novel Platform for Studying Ovarian Biology and Pathophysiology
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https://www.biorxiv.org/content/10.64898/2026.06.22.732379v1?rss=1
2026-06-26doi:10.64898/2026.06.22.732379Cold Spring Harbor Laboratory2026-06-26
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Development of GS-441524 Derivatives as Potent SARS-CoV-2 Mac1 Inhibitors via a Direct-to-Biology Approach
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https://www.biorxiv.org/content/10.64898/2026.06.24.734322v1?rss=1
2026-06-25doi:10.64898/2026.06.24.734322Cold Spring Harbor Laboratory2026-06-25
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Do nanoplastics reshape microglial support of neuronal resilience? A study of microglial bioenergetics and microglia to neuron communication in vitro
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https://www.biorxiv.org/content/10.64898/2026.06.17.732827v1?rss=1
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C_LIO_LINanoplastics biphasically modulate microglial support of neurons.
C_LIO_LIHigh nanoplastic concentration reduces microglial support to neurons.
C_LIO_LIMicroglial bioenergetics may link nanoplastics to neuronal vulnerability.
C_LI
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Ergothioneine, alone or combined with vitamin K2, vitamin D3 and magnesium L-threonate, attenuates bone turnover, inflammatory and oxidative disturbances in ovariectomized mice
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https://www.biorxiv.org/content/10.64898/2026.06.23.734114v1?rss=1
0.05 vs OVX), but significantly increased trabecular area on distal-femoral histology (OVX 7.6% vs 14.2-15.0% across regimens; P < 0.05 vs OVX) and lowered CTX-I, TNF-, IL-6 and MDA while raising SOD and partially restoring PINP and osteocalcin (P < 0.05-0.01 vs OVX). Because the histological and micro-CT endpoints were assessed at different skeletal sites, structural interpretation is cautious. Apparent increases in serum estradiol were assay-dependent and are regarded as exploratory.
Ergothioneine-based nutritional regimens improved the systemic oxidative, inflammatory and bone-turnover environment of estrogen-deficient bone loss and preserved distal-femoral trabecular area on histology, although tibial three-dimensional microarchitecture by micro-CT was not restored. Because the histological and micro-CT endpoints were assessed at different skeletal sites, the structural interpretation is necessarily cautious. These findings support further evaluation of EGT as a dietary adjunct, with mechanistic and dose-optimization studies warranted.
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Discovery of a pathway-selective platelet P2Y1R inverse agonist that suppresses inflammation while preserving hemostasis
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https://www.biorxiv.org/content/10.64898/2026.06.19.732319v1?rss=1
2026-06-24doi:10.64898/2026.06.19.732319Cold Spring Harbor Laboratory2026-06-24
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Ivermectin exposition during neurulation induces Neural tube defects and neuromuscular alterations in Xenopus laevis through purinergic P2X4-signaling.
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https://www.biorxiv.org/content/10.64898/2026.06.19.733173v1?rss=1
2026-06-24doi:10.64898/2026.06.19.733173Cold Spring Harbor Laboratory2026-06-24