bioRxiv Subject Collection: Pharmacology And Toxicology
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This feed contains articles for bioRxiv Subject Collection "Pharmacology And Toxicology"
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Kinetics of cortisol and cortisone binding to corticosteroid binding globulin and albumin in vivo
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https://www.biorxiv.org/content/10.64898/2026.04.14.718600v1?rss=1
2026-04-17doi:10.64898/2026.04.14.718600Cold Spring Harbor Laboratory2026-04-17
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A Nonsteroidal Reversal Agent Inhibits Allopregnanolone Modulation of α1β3δ GABAA Receptors
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https://www.biorxiv.org/content/10.64898/2026.04.14.718525v1?rss=1
2026-04-17doi:10.64898/2026.04.14.718525Cold Spring Harbor Laboratory2026-04-17
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Slow Dissociation of Nitazenes from the μ-Opioid Receptor Underlies the Challenge of Overdose Reversal
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https://www.biorxiv.org/content/10.64898/2026.04.14.718203v1?rss=1
2026-04-16doi:10.64898/2026.04.14.718203Cold Spring Harbor Laboratory2026-04-16
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N-3 Polyunsaturated Fatty Acids Ameliorate Post-infarction Cardiac Dysfunction Through Modulation Of Adiponectin-Ceramide Metabolism
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https://www.biorxiv.org/content/10.64898/2026.04.13.718333v1?rss=1
2026-04-16doi:10.64898/2026.04.13.718333Cold Spring Harbor Laboratory2026-04-16
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Increased utrophin expression in healthy and DMD patient derived myoblasts in response to ERK1/2 and EZH2 inhibitor treatment
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https://www.biorxiv.org/content/10.64898/2026.04.13.718206v1?rss=1
2026-04-15doi:10.64898/2026.04.13.718206Cold Spring Harbor Laboratory2026-04-15
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Three nitrogen atoms turn old kinase inhibitors into new targetable remedy
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https://www.biorxiv.org/content/10.64898/2026.04.11.717649v1?rss=1
2026-04-14doi:10.64898/2026.04.11.717649Cold Spring Harbor Laboratory2026-04-14
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Using Patient iPSC-derived Retinal Pigment Epithelial Cells to Evaluate Differential Susceptibility to MEK Inhibitor-Associated Retinopathy
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https://www.biorxiv.org/content/10.64898/2026.04.11.717944v1?rss=1
2026-04-14doi:10.64898/2026.04.11.717944Cold Spring Harbor Laboratory2026-04-14
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Discovery and Development of First-in-Class Cereblon-Recruiting RIPK1 Degraders
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https://www.biorxiv.org/content/10.64898/2026.04.10.717852v1?rss=1
2026-04-14doi:10.64898/2026.04.10.717852Cold Spring Harbor Laboratory2026-04-14
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Cannabidiol (CBD) Promotes Post-TBI Astrocyte Viability and Decreases Injury-Induced Glial Stress Responses Across Zebra Finch Song Control Nuclei
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https://www.biorxiv.org/content/10.64898/2026.04.13.717820v1?rss=1
2026-04-14doi:10.64898/2026.04.13.717820Cold Spring Harbor Laboratory2026-04-14
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Middle-aged mice treated with GHK-Cu peptide administered intraperitoneally or intranasally show behavioral rescue but divergent hippocampal aging programs
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https://www.biorxiv.org/content/10.64898/2026.04.09.717524v1?rss=1
2026-04-13doi:10.64898/2026.04.09.717524Cold Spring Harbor Laboratory2026-04-13
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Reversible CD28 checkpoint modulation by cyclic peptides outperforms biologic blockade under exposure-limited conditions
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https://www.biorxiv.org/content/10.64898/2026.04.09.717469v1?rss=1
2026-04-13doi:10.64898/2026.04.09.717469Cold Spring Harbor Laboratory2026-04-13
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Impact of Sex on Heroin Intravenous Self-Administration by Heterogeneous Stock Rats
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https://www.biorxiv.org/content/10.64898/2026.04.08.717349v1?rss=1
2026-04-12doi:10.64898/2026.04.08.717349Cold Spring Harbor Laboratory2026-04-12
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Influence of different pharmaceuticals on the germination and early development of two leafy vegetable species
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https://www.biorxiv.org/content/10.64898/2026.04.08.717353v1?rss=1
2026-04-12doi:10.64898/2026.04.08.717353Cold Spring Harbor Laboratory2026-04-12
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Stability of Oxycodone Solutions Containing S-Ketamine or Dexmedetomidine
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https://www.biorxiv.org/content/10.64898/2026.04.08.717252v1?rss=1
2026-04-12doi:10.64898/2026.04.08.717252Cold Spring Harbor Laboratory2026-04-12
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Pinus sp. leaf extracts exert antileishmanial effects against Leishmania donovani by targeting trypanothione reductase
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https://www.biorxiv.org/content/10.64898/2026.04.08.717320v1?rss=1
10) toward Raw264.7 and Vero CRL1586 cells. The ethanolic extract showed a lethal dose (LD) value greater than 5000 mg/kg, thus highlighting its non toxicity upon the acute toxicity test. The metabolomic profiling of the ethanol extract identified several compound classes, including flavanone O-glycosides (e.g. epiafzelechin trimethyl ether), alkaloids (e.g. harmane), and diterpenes (e.g. abietic acid). Further molecular docking studies revealed strong binding affinities of these compounds to trypanothione reductase, thus suggesting the inhibitory potential of these compounds toward the target enzyme. Overall, extracts from Pinus sp. leaves demonstrate promising antileishmanial effects. However, isolation and characterization of the antileishmanial compounds from Pinus sp. leaf, detailed pharmacokinetics, and mechanisms of action are warranted for the successful utilization of this plant in antileishmanial drug discovery.
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PROTAC internalization and target degradation require clathrin-mediatedendocytosis
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https://www.biorxiv.org/content/10.64898/2026.04.06.716751v1?rss=1
2026-04-08doi:10.64898/2026.04.06.716751Cold Spring Harbor Laboratory2026-04-08
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Morphological and Functional Effects of Cytoskeletal and Ion-Channel Agents on the Protoscolex of Echinococcus granulosus sensu lato
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https://www.biorxiv.org/content/10.64898/2026.04.06.716494v1?rss=1
2026-04-08doi:10.64898/2026.04.06.716494Cold Spring Harbor Laboratory2026-04-08
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Synergistic induction of a lethal Autosis-to-Apoptosis switch by phytocannabinoids and β-Caryophyllene in Triple-Negative Breast Cancer Cells
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https://www.biorxiv.org/content/10.64898/2026.04.05.716056v1?rss=1
2026-04-07doi:10.64898/2026.04.05.716056Cold Spring Harbor Laboratory2026-04-07
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Exofection as a Therapeutic Modality: Restoring P-gp Activity via Trophoblast-Derived EV in Neuroinflammatory Disorders
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https://www.biorxiv.org/content/10.64898/2026.04.02.716001v1?rss=1
2026-04-06doi:10.64898/2026.04.02.716001Cold Spring Harbor Laboratory2026-04-06
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Simian Immunodeficiency Virus and Antiretroviral Therapy Impact Rhesus Macaque Brain Lipid Distribution
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https://www.biorxiv.org/content/10.64898/2026.04.03.716347v1?rss=1
2026-04-04doi:10.64898/2026.04.03.716347Cold Spring Harbor Laboratory2026-04-04
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Changes in dysbiosis and gene expression in the gut of wharf roach (Ligia Spp.) fed with expanded polystyrene
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https://www.biorxiv.org/content/10.64898/2026.03.31.715705v1?rss=1
2026-04-03doi:10.64898/2026.03.31.715705Cold Spring Harbor Laboratory2026-04-03
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Low cadmium concentrations alter B and T cell responses in Jamaican fruit bats (Artibeus jamaicensis)
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https://www.biorxiv.org/content/10.64898/2026.03.31.715675v1?rss=1
2026-04-03doi:10.64898/2026.03.31.715675Cold Spring Harbor Laboratory2026-04-03
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Nicotine self-administration increases impulsive action: differential effects of nAChR modulators in a Go/No-Go task
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https://www.biorxiv.org/content/10.64898/2026.03.31.715632v1?rss=1
2026-04-02doi:10.64898/2026.03.31.715632Cold Spring Harbor Laboratory2026-04-02
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Decoding the Structural and Functional Impact of the Leukaemia-Associated A338V Mutation in GPR183
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https://www.biorxiv.org/content/10.64898/2026.03.30.715362v1?rss=1
2026-04-01doi:10.64898/2026.03.30.715362Cold Spring Harbor Laboratory2026-04-01
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Electroconvulsive seizures for alcohol use disorder: a preclinical study
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https://www.biorxiv.org/content/10.64898/2026.03.30.715248v1?rss=1
2026-04-01doi:10.64898/2026.03.30.715248Cold Spring Harbor Laboratory2026-04-01
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Steroid-based Tide Quencher 1 probes enable real-time mapping of novel non-canonical cholesterol sites on the M1 muscarinic receptor
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https://www.biorxiv.org/content/10.64898/2026.03.26.714567v1?rss=1
2026-04-01doi:10.64898/2026.03.26.714567Cold Spring Harbor Laboratory2026-04-01
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In vivo pharmacokinetics and tissue distribution profile of a Wnt/β-catenin pathway-targeting anticancer cassane diterpene isolated from Caesalpinia pulcherrima
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https://www.biorxiv.org/content/10.64898/2026.03.30.715187v1?rss=1
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Cirrina: LLM-driven pharmacological reasoning agent enables preclinical CNS drug evaluation
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https://www.biorxiv.org/content/10.64898/2026.03.29.713781v1?rss=1
2026-03-31doi:10.64898/2026.03.29.713781Cold Spring Harbor Laboratory2026-03-31
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Study comparing characteristics of ademetionine-containing tablets from different countries
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https://www.biorxiv.org/content/10.64898/2026.03.27.714742v1?rss=1
2026-03-30doi:10.64898/2026.03.27.714742Cold Spring Harbor Laboratory2026-03-30
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Targeting Protease-activated Receptor 4 (PAR4) Protects Against Acute Kidney Injury (AKI) in Ischemia Reperfusion Injury
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https://www.biorxiv.org/content/10.64898/2026.03.27.714572v1?rss=1
2026-03-30doi:10.64898/2026.03.27.714572Cold Spring Harbor Laboratory2026-03-30