bioRxiv Subject Collection: Pharmacology And Toxicology
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This feed contains articles for bioRxiv Subject Collection "Pharmacology And Toxicology"
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Orally Bioavailable SARS-CoV-2 Protease Inhibitors Bearing a Hydroxymethyl Ketone Warhead
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https://www.biorxiv.org/content/10.64898/2026.05.15.725542v1?rss=1
2026-05-18doi:10.64898/2026.05.15.725542Cold Spring Harbor Laboratory2026-05-18
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Addiction-Like Severity Predicts Prolonged Oxycodone Withdrawal-Induced Allodynia in Genetically Diverse Rats
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https://www.biorxiv.org/content/10.64898/2026.05.14.725258v1?rss=1
2026-05-18doi:10.64898/2026.05.14.725258Cold Spring Harbor Laboratory2026-05-18
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Discovery of a Novel Non-MET-Mediated Otoprotective Compound Against Aminoglycoside-Induced Ototoxicity
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https://www.biorxiv.org/content/10.64898/2026.05.14.725303v1?rss=1
2026-05-18doi:10.64898/2026.05.14.725303Cold Spring Harbor Laboratory2026-05-18
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Validation and testing of an in vitro model to study medical treatments for anterior urethral stricture disease: assessing the potential efficacy of phosphodiesterase-4 (PDE4) inhibition and testosterone
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https://www.biorxiv.org/content/10.64898/2026.05.13.724950v1?rss=1
2026-05-17doi:10.64898/2026.05.13.724950Cold Spring Harbor Laboratory2026-05-17
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Targeting Microbial Bile Salt Hydrolase Reprograms Bile Acid Metabolism and Ameliorates Metabolic Dysfunction-Associated Steatohepatitis in Mice
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https://www.biorxiv.org/content/10.64898/2026.05.12.724693v1?rss=1
2026-05-17doi:10.64898/2026.05.12.724693Cold Spring Harbor Laboratory2026-05-17
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Report on pre-validation of an animal-free alternative method (NAM) for regulatory safety testing: InfiniteLungDT, an in-vitro-learned digital twin for the prediction of material-triggered chronic neutrophilic lung inflammation
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https://www.biorxiv.org/content/10.64898/2026.05.12.723437v1?rss=1
2026-05-17doi:10.64898/2026.05.12.723437Cold Spring Harbor Laboratory2026-05-17
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Pharmaceutical assessment of low global warming potential alternatives to HFA-134a in a budesonide, glycopyrrolate, and formoterol fumarate pressurized metered dose inhaler
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https://www.biorxiv.org/content/10.64898/2026.05.12.724523v1?rss=1
2026-05-16doi:10.64898/2026.05.12.724523Cold Spring Harbor Laboratory2026-05-16
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An N, S-acetylated L-cysteine-cysteamine conjugate hinders pyocyanin redox cycling to weaken Pseudomonas aeruginosa biofilm and dampens LPS-driven acute pulmonary inflammation
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https://www.biorxiv.org/content/10.64898/2026.05.13.724891v1?rss=1
2026-05-15doi:10.64898/2026.05.13.724891Cold Spring Harbor Laboratory2026-05-15
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Sulfo-DIBMA encapsulation uniquely preserves signalling-competent active states of the class B1 GPCRs, calcitonin gene-related peptide and parathyroid hormone 1 receptors, in native-like nanodiscs
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https://www.biorxiv.org/content/10.64898/2026.05.13.724797v1?rss=1
2026-05-15doi:10.64898/2026.05.13.724797Cold Spring Harbor Laboratory2026-05-15
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Effects of NMDA antagonists on social behaviour: a systematic review and meta-analysis of preclinical studies
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https://www.biorxiv.org/content/10.64898/2026.05.13.724847v1?rss=1
2026-05-15doi:10.64898/2026.05.13.724847Cold Spring Harbor Laboratory2026-05-15
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Topological Pharmacokinetics: Reading the Shape of Drug Disposition from Data
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https://www.biorxiv.org/content/10.64898/2026.05.13.724751v1?rss=1
2026-05-15doi:10.64898/2026.05.13.724751Cold Spring Harbor Laboratory2026-05-15
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A novel pipeline for the validation of manganese chelators for the treatment of manganese overload
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https://www.biorxiv.org/content/10.64898/2026.05.12.724311v1?rss=1
2026-05-15doi:10.64898/2026.05.12.724311Cold Spring Harbor Laboratory2026-05-15
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A Cherry-Flavoured E-Cigarette Adduct, BPGA, Reprograms Alveolar Epithelial Cell Fate Through Epithelial-to-Mesenchymal Transition and Evasion of Apoptosis
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https://www.biorxiv.org/content/10.64898/2026.05.12.724520v1?rss=1
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ERRγ deletion in podocytes accelerates aging related kidney disease
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https://www.biorxiv.org/content/10.64898/2026.05.11.724391v1?rss=1
2026-05-14doi:10.64898/2026.05.11.724391Cold Spring Harbor Laboratory2026-05-14
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Human internal exposures to alternariol and its monomethyl ether are predicted below thresholds of in vitro toxicity by physiologically based kinetic modeling
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https://www.biorxiv.org/content/10.64898/2026.05.11.724263v1?rss=1
2026-05-14doi:10.64898/2026.05.11.724263Cold Spring Harbor Laboratory2026-05-14
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Comparative metabolism of the Alternaria toxins altenuene and tentoxin in rat and human primary hepatocytes
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https://www.biorxiv.org/content/10.64898/2026.05.11.724251v1?rss=1
2026-05-13doi:10.64898/2026.05.11.724251Cold Spring Harbor Laboratory2026-05-13
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Drug Proarrhythmic Evaluation in a High Throughput Cardiac New Approach Methodology
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https://www.biorxiv.org/content/10.64898/2026.05.11.722965v1?rss=1
2026-05-13doi:10.64898/2026.05.11.722965Cold Spring Harbor Laboratory2026-05-13
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Toward a Random Background for Ligand Optimization
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https://www.biorxiv.org/content/10.64898/2026.05.10.724162v1?rss=1
2026-05-13doi:10.64898/2026.05.10.724162Cold Spring Harbor Laboratory2026-05-13
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Adequate coating and change in morphology increase the performances of silver nanoparticular biocides
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https://www.biorxiv.org/content/10.64898/2026.05.11.724204v1?rss=1
2026-05-13doi:10.64898/2026.05.11.724204Cold Spring Harbor Laboratory2026-05-13
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Cyclic Peptides Target CAPON and Modulate Cellular Responses under Alzheimers Disease-Relevant Stress
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https://www.biorxiv.org/content/10.64898/2026.05.10.724063v1?rss=1
2026-05-13doi:10.64898/2026.05.10.724063Cold Spring Harbor Laboratory2026-05-13
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Integrated luminescence and phenotypic profiling for drug discovery in a zebrafish model of Marfan syndrome
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https://www.biorxiv.org/content/10.64898/2026.05.12.722859v1?rss=1
2026-05-13doi:10.64898/2026.05.12.722859Cold Spring Harbor Laboratory2026-05-13
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Acute inflammation-mediated attenuation of behavioural sensitization in methamphetamine-sensitized mice via distinct COX-2 and TNF-α pathways
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https://www.biorxiv.org/content/10.64898/2026.05.08.723429v1?rss=1
2026-05-12doi:10.64898/2026.05.08.723429Cold Spring Harbor Laboratory2026-05-12
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Ramelteon facilitates hippocampal ripple occurrence and amplitude in mice
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https://www.biorxiv.org/content/10.64898/2026.05.08.723673v1?rss=1
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Activation by statins unveils two putative agonist binding sites in the pore domain of TRPA1
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https://www.biorxiv.org/content/10.64898/2026.05.08.723702v1?rss=1
2026-05-12doi:10.64898/2026.05.08.723702Cold Spring Harbor Laboratory2026-05-12
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Virtual screening and zebrafish phenotype-based evaluation argues against repurposing 4-phenylbutyrate for STXBP1-relateddisorders
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https://www.biorxiv.org/content/10.64898/2026.05.07.723632v1?rss=1
2026-05-12doi:10.64898/2026.05.07.723632Cold Spring Harbor Laboratory2026-05-12
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Nephrotoxicity of Immune Checkpoint Inhibitors in Mice with a Human Immune System
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https://www.biorxiv.org/content/10.64898/2026.05.07.723340v1?rss=1
2026-05-12doi:10.64898/2026.05.07.723340Cold Spring Harbor Laboratory2026-05-12
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Systematic toxicological study of PFOS/PFOA co-exposure driving prostate cancer: Core target identification, TME immune remodeling, and combination drug prediction
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https://www.biorxiv.org/content/10.64898/2026.05.07.723528v1?rss=1
2026-05-12doi:10.64898/2026.05.07.723528Cold Spring Harbor Laboratory2026-05-12
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Reversible in vivo regulation of drug metabolizing enzyme CYP1A2 activity through a dTAG knock-in strategy
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https://www.biorxiv.org/content/10.64898/2026.05.06.722533v1?rss=1
2026-05-12doi:10.64898/2026.05.06.722533Cold Spring Harbor Laboratory2026-05-12
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Railway Catenary Sparking as a Source of Toxic Copper Ultrafine Particles: Evidence from Realistic In Vitro Inhalation Exposure
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https://www.biorxiv.org/content/10.64898/2026.05.07.723476v1?rss=1
2026-05-11doi:10.64898/2026.05.07.723476Cold Spring Harbor Laboratory2026-05-11
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Sex-specific amplification of IKr-blocker-induced action potential prolongation by reduced female IKs repolarization reserve: a computational study using the O'Hara-Rudy human ventricular model
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https://www.biorxiv.org/content/10.64898/2026.05.07.723338v1?rss=1
500 ms, a conservative cellular risk marker informed by clinical QTc safety thresholds, or failure to repolarize within the cycle length) were quantified. All simulations used SciPys Radau solver (rtol = 10-, atol = 10-8) with a Numba-JIT-compiled right-hand side for computational efficiency.
ResultsAt baseline (0% block), the female model exhibited longer APD90 than the male at all pacing rates (+2.8 ms at 2 Hz; +4.6 ms at 1 Hz; +4.6 ms at 0.5 Hz). Under progressive IKr blockade, the absolute sex difference in APD90 amplified non-linearly: at 85% block and 1 Hz pacing the female APD90 exceeded the male by 60.4 ms (versus 4.6 ms at baseline; 13-fold amplification). At slow pacing (0.5 Hz), the sex gap was most pronounced: at 85% block, female APD90 was 1127 ms versus 939 ms for the male (+188 ms; 20% more prolonged). The critical APD threshold (>500 ms) was reached by female cells at 5 percentage points lower IKr block than male cells at 1 Hz pacing (55% vs. 60% block), both reported at the first simulated 5%-grid block level exceeding the criterion. Repolarization failure occurred 5 percentage points earlier in females at 1 Hz (90% vs. 95% block). Action potential triangulation was consistently greater in the female model at all block levels and pacing rates.
ConclusionA 45% reduction in IKs conductance is sufficient in this model to produce measurably greater APD90 prolongation under IKr blockade across all tested pacing rates. The non-linear amplification of the sex gap is consistent with the hypothesis that reduced IKs repolarization reserve contributes to greater female susceptibility to drug-induced QT prolongation, and supports testing sex-specific parameterizations in CiPA-style in silico cardiac safety workflows.
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